FedInvent™ Patent Applications
Patent Application Details for Thursday, August 26, 2021
This page was updated on Thursday, August 26, 2021 at 07:39 PM GMT
Department of Health and Human Services (HHS)
| US 20210259657 | Gallippi et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Caterina Gallippi (Cary, North Carolina); Gabriela Torres (Chapel Hill, North Carolina) |
| ABSTRACT | A method for evaluating mechanical anisotropy of a material sample to determine a characteristic of the sample includes interrogating a material sample a plurality of times. Each interrogation includes: applying a force having a direction, having a coronal plane normal to the direction of the force, and having an oval or other profile with long and short axes within the coronal plane, the long axis being oriented at a specified angle from a reference direction within the coronal plane; and measuring displacement of the material sample resulting from application of the force. The interrogations are taken at different angles of orientation within the coronal plane and different portions of the material sample are interrogated. For each measurement one or more parameters are calculated for the respective angle of orientation. A degree of anisotropy of the one or more parameters is determined and used to evaluate a characteristic of the material sample. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176772 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/54 (20130101) A61B 8/0825 (20130101) Original (OR) Class A61B 8/5207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210259765 | Narayan |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanjiv M. Narayan (Palo Alto, California) |
| ABSTRACT | An ablation catheter for treating electrical rhythm disorders includes an array of sensor electrodes to detect electrical signals to determine a location of a target region for treatment. If the catheter is not optimally positioned at the target region, a controller uses the detected signals to guide movement of the catheter towards the target region. Once proper positioning is ascertained, the controller activates ablation components within the catheter to deliver energy to modify tissue at the target region. |
| FILED | Saturday, February 20, 2021 |
| APPL NO | 17/180783 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/02 (20130101) A61B 18/1492 (20130101) Original (OR) Class A61B 2018/00351 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210259777 | Chatzizisis |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ioannis S. Chatzizisis (Omaha, Nebraska) |
| ABSTRACT | In accordance with embodiments of this disclosure, a computational simulation platform comprises a computer-implemented method that includes: generating a mesh or meshless three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging; assigning material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging; performing balloon pre-dilation, stenting and balloon post-dilation computational simulations with the 3D reconstructed vessel lumen and surface of the vessel lumen; and assessing stent and vessel morphometric and biomechanical measures based on the computational simulations. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314338 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/10 (20160201) Original (OR) Class A61B 90/37 (20160201) A61B 2034/102 (20160201) A61B 2034/105 (20160201) A61B 2090/378 (20160201) A61B 2090/3762 (20160201) Image Data Processing or Generation, in General G06T 17/20 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210259954 | Pala et al. |
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| FUNDED BY |
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| APPLICANT(S) | Chapman University (Orange, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajasekharreddy Pala (Orange, California); Surya M. Nauli (Orange, California) |
| ABSTRACT | Disclosed herein are cilia-targeting nanoparticles and methods of treating ciliopathies. |
| FILED | Friday, November 27, 2020 |
| APPL NO | 17/105949 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) Original (OR) Class A61K 9/5015 (20130101) A61K 9/5031 (20130101) A61K 9/5115 (20130101) A61K 9/5153 (20130101) A61K 31/55 (20130101) A61K 39/39533 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) Peptides C07K 16/286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210259968 | IRVINE et al. |
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| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell J. IRVINE (Arlington, Massachusetts); Matthias STEPHAN (Boston, Massachusetts); Jaehyun MOON (Cambridge, Massachusetts); Anna BERSHTEYN (Seattle, Washington) |
| ABSTRACT | The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively. |
| FILED | Tuesday, October 13, 2020 |
| APPL NO | 17/069305 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 9/127 (20130101) Original (OR) Class A61K 9/146 (20130101) A61K 9/5146 (20130101) A61K 9/5153 (20130101) A61K 31/711 (20130101) A61K 31/7105 (20130101) A61K 35/28 (20130101) A61K 38/19 (20130101) A61K 38/20 (20130101) A61K 38/2086 (20130101) A61K 39/00 (20130101) A61K 39/39 (20130101) A61K 39/395 (20130101) A61K 45/06 (20130101) A61K 47/46 (20130101) A61K 47/6901 (20170801) A61K 47/6911 (20170801) A61K 47/6937 (20170801) A61K 2035/124 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 16/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0006 (20130101) C12N 5/0636 (20130101) C12N 5/0647 (20130101) C12N 15/87 (20130101) C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260002 | GOLDMAN et al. |
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| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York); UNIVERSITY OF COPENHAGEN (Copenhagen K, Denmark) |
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| INVENTOR(S) | Steven A. GOLDMAN (Webster, New York); Zhengshan LIU (Rochester, New York); Mikhail OSIPOVITCH (Frederiksberg, Denmark) |
| ABSTRACT | The present disclosure is directed to methods of restoring glial cell K+ uptake in a subject. This method involves selecting a subject having impaired glial cell K+ uptake, and administering, to the selected subject, a RE1-Silencing Transcription factor (REST) inhibitor under conditions effective to restore glial cell K+ uptake. Subjects having impaired glial cell K+ uptake include those at risk of having or having a neuropsychiatric disease or disorder. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/254008 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/16 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260009 | GARRETT |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts) |
| INVENTOR(S) | Wendy GARRETT (Boston, Massachusetts) |
| ABSTRACT | Provided herein are methods, compositions, and assays related to regulating the level or activity of hydrogen sulfide (H2S) in a subject. The methods, compositions, and assays are also related to treating, alleviating, and preventing an inflammatory or fibrotic disease of the kidney in a subject in need thereof. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180136 |
| CURRENT CPC | Fodder A23K 20/142 (20160501) A23K 50/40 (20160501) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/40 (20160801) A23L 33/175 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0029 (20130101) A61K 9/0053 (20130101) A61K 9/0056 (20130101) A61K 31/198 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260021 | Kashanchi et al. |
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| FUNDED BY |
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| APPLICANT(S) | GEORGE MASON RESEARCH FOUNDATION, INC. (Fairfax, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fatah Kashanchi (Potomac, Maryland); Catherine DeMarino (Annandale, Virginia) |
| ABSTRACT | This disclosure relates to methods and compositions for inhibiting release of extracellular vesicles from a cell infected by a virus. One aspect of the disclosure relates to methods for treating viral diseases, reducing damage to a neuron from the central neural system (“CNS”) and/or treating neuroinflammation in a subject. In another aspect, provided herein are methods for inhibiting transcription of a viral RNA and/or release of extracellular vesicles from a cell infected by a virus. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/227786 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/352 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260039 | SYED et al. |
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| FUNDED BY |
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| APPLICANT(S) | MEND NUTRITION INC. (New York, New York) |
| ASSIGNEE(S) | MEND NUTRITION INC. (New York, New York) |
| INVENTOR(S) | Eziah SYED (New York, New York); Hans DRYER (Eugene, Oregon); Erin C. OWEN (Eugene, Oregon) |
| ABSTRACT | Compositions comprising a plurality of particular essential amino acids, and methods of enhancing muscle performance by administering such compositions are provided herein. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/261713 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/175 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0095 (20130101) A61K 31/198 (20130101) A61K 31/205 (20130101) A61K 31/405 (20130101) A61K 31/4172 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260057 | Bhowmick et al. |
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| FUNDED BY |
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| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Neil Bhowmick (Beverly Hills, California); Rajeev Mishra (Los Angeles, California); Bethany Smith (Lancaster, California) |
| ABSTRACT | The present disclosure provides compositions, markers, and methods for diagnosing and treating cancer and other conditions. The method includes administering at least one androgen deprivation therapy to the subject; and administering a therapeutically effective amount of at least one inhibitor to the subject, wherein the at least one inhibitor is selected from the group including: at least one macropinocytosis inhibitor, at least one glutamine metabolism inhibitor, at least one glutaminase inhibitor, and any combinations thereof. |
| FILED | Friday, July 12, 2019 |
| APPL NO | 17/257531 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/433 (20130101) A61K 31/501 (20130101) Original (OR) Class A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6812 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260092 | MILLER et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | New York University (New York, New York) |
| INVENTOR(S) | George MILLER (Englewood, New Jersey); Berk AYKUT (Brooklyn, New York); Deepak SAXENA (New York, New York); Smruti PUSHALKAR (New York, New York) |
| ABSTRACT | The application relates to methods based on modulating pancreatic and/or gastrointestinal microbiota and related antifungal compositions. Specifically, the application relates to the use of microbiome for prevention, treatment and diagnosis of pancreatic cancers or tumors, such as pancreatic ductal adenocarcinoma. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/038813 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7048 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260098 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Liu (Chapel Hill, North Carolina); Jine Li (Chapel Hill, North Carolina); Guowei Su (Chapel Hill, North Carolina); Rafal Pawlinski (Chapel Hill, North Carolina); Erica Sparkenbaugh (Chapel Hill, North Carolina) |
| ABSTRACT | Chondroitin sulfate compounds comprising chondroitin sulfate backbone 19 mer, CS-A 19 mer, CS-C 19 mer, CS-E 19 mer, C8 backbone 13 mer, C8-A 13 mer, CS-C 13 mer, CS-E 13 mer and/or combinations thereof are provided. Methods of treating histone toxicity in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the histone toxicity in the subject. Pharmaceutical compositions for use in treating histone toxicity and/or sepsis are provided. Methods of treating sepsis in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the sepsis in the subject. |
| FILED | Wednesday, June 19, 2019 |
| APPL NO | 17/254145 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/737 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260101 | Rice et al. |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles V. Rice (Norman, Oklahoma); Daniel T. Glatzhofer (Norman, Oklahoma) |
| ABSTRACT | Compositions of β-lactam antibiotics and branched poly(ethylenimine) (BPEI), and β-lactam antibiotics and potentiating compounds of polyethylene glycol (PEG)-BPEI conjugates, and methods of their use to treat infections and to remove bacterial biofilms from surfaces of devices and wounds. The BPEI and PEG-BPEI conjugates potentiate the activity of the β-lactam antibiotics so the compositions have synergistic effects against various Gram-positive bacteria. For example, the compositions can be used to treat Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-resistant Staphylococcus epidermidis (MRSE), that have developed resistance against most β-lactam antibiotics. The BPEI and PEG-BPEI conjugates result in the resensitization of such resistant bacterial strains to traditional antibiotic therapies such as β-lactam antibiotics. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231854 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 33/04 (20130101) A01N 43/44 (20130101) A01N 43/86 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/407 (20130101) A61K 31/427 (20130101) A61K 31/785 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260109 | SHAFIKHANI |
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| FUNDED BY |
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| APPLICANT(S) | Rush University Medical Center (Chicago, Illinois) |
| ASSIGNEE(S) | Rush University Medical Center (Chicago, Illinois) |
| INVENTOR(S) | Sasha SHAFIKHANI (Elmwood Park, Illinois) |
| ABSTRACT | Methods of administering apoptotic compensatory proliferation signaling vesicles (AC PS Vs), and pharmaceutical formulations thereof, are described herein. AC PS Vs can be used to promote proliferation of cells in injured or diseased tissues, for example by adding a therapeutically effective amount of APCSVs to the injured or diseased tissue. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/252782 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 35/13 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260111 | Liu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia State University Research Foundation, Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuan Liu (Decatur, Georgia); Zhen Bian (Atlanta, Georgia); Ke Zen (Decatur, Georgia) |
| ABSTRACT | The present invention relates to compositions and methods variously useful in treating cancer, inhibiting graft rejection, and treating autoimmune disease. The compositions and methods include those in which macrophages are conditioned to down regulate or upregulate the expression or activity of SIRPα or its interaction with CD47. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/315987 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/739 (20130101) A61K 31/7088 (20130101) A61K 35/15 (20130101) Original (OR) Class A61K 38/19 (20130101) A61K 38/191 (20130101) A61K 38/204 (20130101) A61K 38/2006 (20130101) A61K 39/395 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/244 (20130101) C07K 16/2896 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0645 (20130101) C12N 15/1138 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260117 | MORIARITY et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); Intima Bioscience, Inc. (New York, New York); The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Branden MORIARITY (Shoreview, Minnesota); Beau WEBBER (Coon Rapids, Minnesota); Modassir CHOUDHRY (New York, New York); R. Scott MCIVOR (St. Louis Park, Minnesota); David LARGAESPADA (Mounds View, Minnesota); Steven A. ROSENBERG (Potomac, Maryland); Douglas C. PALMER (North Bethesda, Maryland); Nicholas P. RESTIFO (Chevy Chase, Maryland) |
| ABSTRACT | Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer. |
| FILED | Wednesday, August 26, 2020 |
| APPL NO | 17/003081 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Peptides C07K 14/4718 (20130101) C07K 14/7051 (20130101) C07K 14/7158 (20130101) C07K 14/70503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/87 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260125 | Kochenderfer et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | James N. Kochenderfer (Bethesda, Maryland); Steven A. Feldman (Redwood City, California) |
| ABSTRACT | Provided are chimeric antigen receptors (CARs) having antigenic specificity for B-cell Maturation Antigen (SLAMF7). Also provided are related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs. Methods of treating or preventing cancer in a mammal are also provided. |
| FILED | Wednesday, June 26, 2019 |
| APPL NO | 17/255005 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260134 | Christman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (OaKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karen Christman (San Diego, California); Jennifer Singelyn (Riverdale, New Jersey); Jessica DeQuach (La Jolla, California) |
| ABSTRACT | Described herein are compositions comprising decellularized cardiac extracellular matrix and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damaged or ischemic cells, tissues or organs in a subject, preferably a human, using a decellularized cardiac extracellular matrix of the invention are provided. Methods of preparing cardiomyocyte culture surfaces and culturing cells with absorbed decellularized cardiac extracellular matrix are provided. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135785 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3633 (20130101) A61L 27/3834 (20130101) A61L 2400/06 (20130101) A61L 2430/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260152 | Parker et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karen J. Parker (Stanford, California); Dean S. Carson (Graceville, QLD, Australia); Antonio Y. Hardan (Stanford, California) |
| ABSTRACT | Provided herein are methods for treating, reducing and/or ameliorating symptoms of autism spectrum disorder (ASD) in a subject, where at least one measure of social impairment, anxiety, or repetitive behaviors is treated and/or ameliorated. Aspects include intranasally administering arginine vasopressin (AVP), or an analog of vasopressin, to a subject (e.g., a child between 6 and 12 years of age and having endogenous pre-treatment levels between about 0.045 and about 4.028 pg/mL, where the mean was 1.324 pg/mL). In children having high pre-treatment blood levels of AVP (e.g., about 25% or more above the mean pre-treatment AVP blood levels of the treatment group; or having pre-treatment blood vasopressin levels greater than 1.324 pg/mL), the treatment was enhanced. Because no difference in pre-treatment blood AVP levels was observed between control and ASD subjects, it was surprising that AVP treatment was more effective in subjects having high pre-treatment AVP levels. |
| FILED | Wednesday, July 10, 2019 |
| APPL NO | 17/252186 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 38/095 (20190101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) G01N 2333/575 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260172 | Montaño-Suarez et al. |
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| FUNDED BY |
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| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); Pontificia Universidad Javeriana (Bogota, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adriana M. Montaño-Suarez (St. Louis, Missouri); Angela Catalina Sosa-Molano (Bogota, Colombia); Alan Knutsen (Webster Groves, Missouri); Clifford Bellone (St. Louis, Missouri); Shunji Tomatsu (Wilmington, Delaware); Luis Barrera (Bogota, Colombia) |
| ABSTRACT | Disclosed are methods and compositions for determining immunodominant peptides of target enzymes used in enzyme replacement therapy for lysosomal storage disorders. More specifically disclosed are immunodominant peptides for N-acetylgalactosamine-6-sulfatase (GALNS). Also disclosed are methods of inducing oral tolerance towards a target enzyme through oral administration of immunodominant peptides prior to commencing enzyme replacement therapy. More specifically disclosed is a method of inducing oral tolerance for GALNS, by orally administering specific immunodominant peptides for GALNS; in subjects suffering from mucopolysaccharidosis type IVA prior to commencing enzyme replacement therapy using GALNS. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314510 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 38/465 (20130101) Original (OR) Class Enzymes C12Y 301/06004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260179 | GARCIA-SASTRE et al. |
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| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| INVENTOR(S) | Adolfo GARCIA-SASTRE (New York, New York); Peter PALESE (New York, New York); Florian KRAMMER (New York, New York); Felix BRÖCKER (Berlin, Germany); Weina SUN (New York, New York) |
| ABSTRACT | In one aspect, provided herein is a mosaic influenza virus hemagglutinin (HA) polypeptide comprising an influenza A virus HA ectodomain of an influenza A virus strain HA, wherein the HA ectodomain comprises an HA stem domain of the influenza A virus strain HA and an HA globular head domain of the influenza A virus strain HA, wherein the HA globular head domain of the influenza A virus strain HA has been engineered to comprise one or more amino acid substitutions in one, two, three, four or all of the antigenic sites. In another aspect, provided herein are immunogenic compositions comprising such a mosaic influenza virus HA polypeptide or an influenza A virus comprising such a mosaic influenza virus HA polypeptide. In yet another aspect, provided herein are methods for immunizing a subject against an influenza A vims in a subject comprising administering such an immunogenic composition to the subject. |
| FILED | Thursday, June 20, 2019 |
| APPL NO | 17/252638 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) A61P 37/04 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/16121 (20130101) C12N 2760/16122 (20130101) C12N 2760/16123 (20130101) C12N 2760/16134 (20130101) C12N 2760/16171 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260183 | Tang |
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| FUNDED BY |
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| APPLICANT(S) | Altimmune, Inc (Gaithersburg, Maryland) |
| ASSIGNEE(S) | Altimmune, Inc (Gaithersburg, Maryland) |
| INVENTOR(S) | De-chu C Tang (Plano, Texas) |
| ABSTRACT | The present invention shows that intranasal administration of E1/E3-defective adenovirus particles may confer rapid and broad protection against viral and bacterial pathogens in a variety of disease settings. Protective responses lasted for many weeks in a single-dose regimen in animal models. When a pathogen-derived antigen gene was inserted into the E1/E3-defective adenovirus genome, the antigen-induced protective immunity against the specific pathogen was elicited before the adenovirus-mediated protective response declined away, thus conferring rapid, prolonged, and seamless protection against pathogens. In addition to E1/E3-defective adenovirus, other bioengineered non-replicating vectors encoding pathogen-derived antigens may also be developed into a new generation of rapid and prolonged immunologic-therapeutic (RAPIT). |
| FILED | Sunday, March 28, 2021 |
| APPL NO | 17/214885 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 39/00 (20130101) A61K 39/07 (20130101) A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/145 (20130101) A61K 39/155 (20130101) A61K 39/215 (20130101) Original (OR) Class A61K 39/235 (20130101) A61K 2039/58 (20130101) A61K 2039/70 (20130101) A61K 2039/541 (20130101) A61K 2039/543 (20130101) A61K 2039/545 (20130101) A61K 2039/5254 (20130101) A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10034 (20130101) C12N 2710/10043 (20130101) C12N 2760/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260184 | PERMAR et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sallie PERMAR (Durham, North Carolina); Cody NELSON (Durham, North Carolina); Jennifer JENKS (Durham, North Carolina) |
| ABSTRACT | The invention is directed to multivalent HCMV immunogenic compositions and their use. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/261554 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/245 (20130101) A61K 39/295 (20130101) Original (OR) Class A61K 2039/70 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/00034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260198 | GU et al. |
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| FUNDED BY |
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| APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhen GU (Raleigh, North Carolina); Chao WANG (Raleigh, North Carolina) |
| ABSTRACT | Disclosed herein is a glucose-responsive insulin delivery system based on the interaction between the glucose-modified insulin and glucose transporters (GLUTs) on erythrocytes (or red blood cells, RBCs). After being conjugated with glucose, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of blood glucose (BG) level in vivo. In some embodiments, the delivery vehicle can include: 1) intravenously injectable polymeric nanoparticles (˜100 nm in diameter) coated with RBC membrane and loaded with glucose-modified insulin and/or 2) painless microneedle (MN) patches loaded with the complex of GLUT and glucose-modified insulin. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188583 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) A61K 35/18 (20130101) A61K 38/28 (20130101) A61K 47/60 (20170801) A61K 47/64 (20170801) A61K 47/549 (20170801) Original (OR) Class A61K 47/6937 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 13/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260202 | Fukuda et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sanford-Burnham Medical Research Institute (La Jolla, California); Hamamatsu University School of Medicine (Higashi-ku, Japan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michiko Fukuda (La Jolla, California); Kazuhiro Sugihara (Higashi-ku, Japan); Naohira Kanayama (Higashi-ku, Japan) |
| ABSTRACT | Compositions and methods related to annexin 1-binding compounds. Also compositions comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Isolated nucleic acids comprising a nucleic acid sequence encoding a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods comprising administering to a subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods of targeting a tumor cell in a subject comprising administering to the subject a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods of targeting a tumor cell in a subject comprising administering to the subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240714 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260217 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gong Chen (State College, Pennsylvania); Ziyuan Guo (Lexington, Kentucky); Zheng Wu (State College, Pennsylvania); Zifei Pei (State College, Pennsylvania); Yuchen Chen (Bellefonte, Pennsylvania) |
| ABSTRACT | This document provides methods and materials for generating GABAergic neurons in brains. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide and nucleic acid encoding a Dlx2 polypeptide to trigger glial cells (e.g., NG2 glial cells or astrocytes) within the brain (e.g., striatum) into forming GABAergic neurons (e.g., neurons resembling medium spiny neurons such as DARPP32-positive GABAergic neurons) that are functionally integrated into the brain of a living mammal (e.g., a human) are provided. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178972 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2227/105 (20130101) A01K 2267/0318 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0085 (20130101) A61K 38/1709 (20130101) A61K 48/0058 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/13043 (20130101) C12N 2750/14143 (20130101) C12N 2840/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260222 | MORROW et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janet R. MORROW (Williamsville, New York); Zuiru LIN (Williamsville, New York); Didar ASIK (Tonawanda, New York); Eric M. SNYDER (Tonawanda, New York); Elizabeth A. KRAS (Amherst, New York) |
| ABSTRACT | Macrocyclic complexes and macrocyclic compounds. The macrocyclic complexes or macrocyclic compounds have a TACN moiety with one or more amine group(s) or a O- or S-substituted TACN moiety. The macrocyclic complexes have a high-spin Fe(III) atom coordinated to the TACN moiety. The macrocyclic complexes can be used in imaging methods. |
| FILED | Monday, November 18, 2019 |
| APPL NO | 16/973349 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/106 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6515 (20130101) C07F 15/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260224 | Ye |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keqiang Ye (Lilburn, Georgia) |
| ABSTRACT | This disclosure relates to styrylbenzothiazole derivatives for use as in vivo imaging agents for the diagnosis of Parkinson's disease (PD) or other degenerative disorders or conditions of the central nervous system. Early diagnosis is particularly advantageous as neuroprotective treatment can be applied to healthy neural cells to delay or even prevent the onset of debilitating clinical symptoms. |
| FILED | Thursday, May 16, 2019 |
| APPL NO | 17/055935 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0453 (20130101) Original (OR) Class General Methods of Organic Chemistry; Apparatus Therefor C07B 59/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260256 | Boodagh et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Parnaz Boodagh (Boulder, Colorado); Wei Tan (Broomfield, Colorado); Michael Floren (Broomfield, Colorado) |
| ABSTRACT | The present invention relates to a medical implant, and more particularly, to a vascular implant having a dual coating structure for preventing in-stent restenosis and thrombosis. In one embodiment, the invention contemplates a vascular stent with a coating comprising a hydrophobic, degradable core with a coaxial sheath comprising at least one polyethylene-glycol derivative. In one embodiment, said at least one polyethylene-glycol derivative comprises polyethylene-glycol dimethacrylate. |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/255879 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/507 (20130101) A61L 31/10 (20130101) Original (OR) Class A61L 31/16 (20130101) A61L 2300/604 (20130101) A61L 2400/12 (20130101) A61L 2430/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260266 | CONWAY et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland); University of Maryland Medical Center, LLC (Linthicum, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Gregory CONWAY (Baltimore, Maryland); Bartley GRIFFITH (Gibson Island, Maryland); Zhongjun WU (Marriottsville, Maryland) |
| ABSTRACT | A demand-adapting and auto-regulatory ECMO system and method is disclosed that may be configured to provide complete cardiopulmonary replacement. The system and method employ a blood gas exchanger having a blood inlet, a blood outlet, a gas inlet, and a gas outlet, an oxygen sensor positioned to detect oxyhemoglobin saturation at the blood inlet, and a carbon dioxide sensor positioned to detect exhaust gas CO2 concentration at the gas outlet. A controller communicates with the oxygen sensor and the carbon dioxide sensor and controls blood flow and gas flow through the blood gas exchanger in response to a sensed oxygen level by the oxygen sensor and a sensed carbon dioxide level by the carbon dioxide sensor, in turn maintaining the sensed oxygen level and the sensed carbon dioxide level within a pre-designated range of values to maintain a patients metabolic requirements. |
| FILED | Thursday, June 20, 2019 |
| APPL NO | 17/253673 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/1698 (20130101) Original (OR) Class A61M 1/3666 (20130101) A61M 2205/3334 (20130101) A61M 2230/202 (20130101) A61M 2230/205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260372 | Ward |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Matthew P. Ward (Zionsville, Indiana) |
| ABSTRACT | A gastric electric stimulation (GES) system is disclosed which includes a processing system, and at least one of a left vagus nerve sensor (L/R Sensors) and a right vagus nerve sensor coupled to the processing system, the processing system is configured to receive a model which statistically correlates sensed compound nerve action potential (CNAP) parameters measured from at least one of left and right vagus nerves of subjects within a population to feedback surveys of the subjects corresponding to a plurality of gastric symptoms and symptom parameters, receive one or more gastric symptoms of a subject outside of the population (Subjectout), determine CNAP parameters that correspond to the gastric symptoms with least severity (CNAPmin), measure CNAP activity of the Subjectout from the L/R sensors while modifying GES parameters for the Subjectout, select the GES parameters that corresponds to the CNAPmin (GESout), and output the GESout. |
| FILED | Sunday, December 20, 2020 |
| APPL NO | 17/128123 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36007 (20130101) Original (OR) Class A61N 1/36053 (20130101) A61N 1/36071 (20130101) A61N 1/36132 (20130101) A61N 1/36139 (20130101) A61N 1/36167 (20130101) A61N 1/36171 (20130101) A61N 1/36175 (20130101) A61N 1/37252 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 20/30 (20180101) G16H 40/67 (20180101) G16H 50/20 (20180101) G16H 50/70 (20180101) G16H 50/80 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260381 | Kilgore et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin L. Kilgore (Avon Lake, Ohio); Niloy Bhadra (Cleveland Heights, Ohio) |
| ABSTRACT | A method of blocking signal transmission through a nerve, with reduced onset activity includes applying an HFAC to an axon of a nerve to block the transmission of signals through the axon. The method may also include applying a direct current (DC) to the axon, increasing the amplitude of the DC over time to a predetermined amplitude, applying the HFAC, and then decreasing the DC. The method may also include temporarily reducing the amplitude of the HFAC to permit the transmission of signals through the axon and subsequently increasing the amplitude to block transmission without triggering an onset response. The method may also include temporarily applying an unbalanced charge to the nerve and then balancing the charge over time. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/239752 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/20 (20130101) A61N 1/32 (20130101) A61N 1/205 (20130101) A61N 1/0551 (20130101) A61N 1/3615 (20130101) A61N 1/36057 (20130101) A61N 1/36067 (20130101) A61N 1/36071 (20130101) A61N 1/36103 (20130101) A61N 1/36167 (20130101) A61N 1/36171 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260562 | SHAIKH et al. |
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| FUNDED BY |
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| APPLICANT(S) | XPLOSAFE, LLC (Stillwater, Oklahoma) |
| ASSIGNEE(S) | XPLOSAFE, LLC (Stillwater, Oklahoma) |
| INVENTOR(S) | Shoaib F. SHAIKH (Stillwater, Oklahoma); Allen W. APBLETT (Stillwater, Oklahoma); Nicholas F. MATERER (Stillwater, Oklahoma); Evgueni KADOSSOV (Stillwater, Oklahoma); Michael L. TEICHEIRA (Stillwater, Oklahoma) |
| ABSTRACT | The present invention provides an improved sorbent and corresponding device(s) and uses thereof for the capture and stabilization of volatile organic compounds (VOC) or semi-volatile organic compounds (SVOC) from a gaseous atmosphere. The sorbent is capable of rapid and high uptake of one or more compounds and provides quantitative release (recovery) of the compound(s) when exposed to elevated temperature and/or organic solvent. Uses of particular improved grades of mesoporous silica are disclosed. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157526 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/106 (20130101) B01D 2257/708 (20130101) B01D 2259/4583 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) Original (OR) Class B01J 20/3204 (20130101) B01J 20/3219 (20130101) B01J 20/3246 (20130101) B01J 20/3293 (20130101) B01J 20/28021 (20130101) B01J 20/28064 (20130101) B01J 20/28073 (20130101) B01J 20/28076 (20130101) B01J 20/28083 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/18 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2004/04 (20130101) C01P 2004/13 (20130101) C01P 2006/12 (20130101) C01P 2006/14 (20130101) C01P 2006/16 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/0091 (20130101) C06B 23/00 (20130101) C06B 45/00 (20130101) Blasting F42D 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261497 | Sun et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); The University of Pittsburgh - of the Commonwealth of Higher Education (Pittsburgh, Pennsylvania); Xiamen University (Xiamen, China PRC); University of Exeter (Exeter, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dandan Sun (Pittsburgh, Pennsylvania); Xianming Deng (Xiamen, Fujian, China PRC); Jinwei Zhang (Exeter, United Kingdom); Mohammad Iqbal Hossain Bhuiyan (Pittsburgh, Pennsylvania); Bradley J. Molyneaux (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/177056 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Acyclic or Carbocyclic Compounds C07C 255/44 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261500 | PEI et al. |
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| FUNDED BY |
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| APPLICANT(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Dehua PEI (Columbus, Ohio); George APPIAH KUBI (Columbus, Ohio); Ziqing QIAN (Wellesley, Massachusetts) |
| ABSTRACT | Disclosed are compounds that can penetrate the mitochondrial membrane and that are able to deliver cargo (e.g., therapeutic agents) specifically to the mitochondria. |
| FILED | Monday, May 06, 2019 |
| APPL NO | 17/052935 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) A61K 47/542 (20170801) Acyclic or Carbocyclic Compounds C07C 279/12 (20130101) Original (OR) Class Peptides C07K 5/06086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261503 | KATTAMURI et al. |
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| FUNDED BY |
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| APPLICANT(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | Padmanabha Venkatesh KATTAMURI (Houston, Texas); Laszlo KURTI (Houston, Texas) |
| ABSTRACT | In one aspect, the present disclosure provides methods of preparing a secondary amine. In some embodiments, the secondary amine comprises two different groups or two identifical groups. Also provided herein are compositions for use in the preparation of the secondary amine. |
| FILED | Thursday, May 17, 2018 |
| APPL NO | 16/614272 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 69/36 (20130101) C07C 69/675 (20130101) C07C 227/06 (20130101) C07C 229/04 (20130101) C07C 311/19 (20130101) Original (OR) Class C07C 381/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261504 | Edinger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Université de Montréal (Montreal, Canada) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); The Université de Montréal (Montreal, Canada) |
| INVENTOR(S) | Aimee L. Edinger (Irvine, California); Stephen Hanessian (Irvine, California) |
| ABSTRACT | Small molecules comprised of azacyclic constrained sphingolipid-like compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/195556 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 207/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261516 | Schneekloth, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Yale University (New Haven, Connecticut) |
| INVENTOR(S) | John Schneekloth, JR. (Frederick, Maryland); John Simmons (Bethesda, Maryland); Kenneth Felsenstein (Bethesda, Maryland); Beverly Mock (Bethesda, Maryland); Lindsey Saunders (Frederick, Maryland); Peter Gareiss (West Haven, Connecticut); David Calabrese (Frederick, Maryland); Elena Leon (Bethesda, Maryland) |
| ABSTRACT | Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306756 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/343 (20130101) A61K 31/397 (20130101) A61K 31/439 (20130101) A61K 31/496 (20130101) A61K 31/4025 (20130101) A61K 31/4525 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 307/84 (20130101) Original (OR) Class C07D 405/06 (20130101) C07D 471/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261526 | Lindsley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig W. Lindsley (Brentwood, Tennessee); P. Jeffrey Conn (Nashville, Tennessee); Darren W. Engers (Brentwood, Tennessee); Julie L. Engers (Brentwood, Tennessee); Aaron M. Bender (Spring Hill, Tennessee); Madeline Long (Nashville, Tennessee) |
| ABSTRACT | Described are positive allosteric modulators of muscarinic acetylcholine receptor M1 (mAChR M1), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 17/251649 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 405/14 (20130101) C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261532 | Lennek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tosk, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Annie L. Lennek (Mountain View, California); Stephen D. Yanofsky (Mountain View, California); Brian D. Frenzel (Mountain View, California); Solomon B. Ungashe (Mountain View, California); William A. Garland (Mountain View, California); Philip Liaw (Mountain View, California) |
| ABSTRACT | RAS modulating compounds and methods of using the same are provided. The compounds find use in modulating the activity of a target RAS in a sample. The target RAS can be a mutant RAS that is implicated in a disease of interest. In some cases, the subject compounds can inhibit the growth of cancer cells whose progression is driven by kRAS or a mutated kRAS. Methods of treating a subject for a RAS driven disease including administering a therapeutically effective amount of the subject compound are provided. Also provided are pharmaceutical compositions and kits which include the subject compounds. |
| FILED | Tuesday, August 06, 2019 |
| APPL NO | 17/260711 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/14 (20130101) Original (OR) Class C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261551 | Gray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Nicholas Paul Kwiatkowski (Brookline, Massachusetts) |
| ABSTRACT | The present invention provides novel compounds of Formula (I), (II), or (III), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, ovarian cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., CDK7, CDK12, or CDK13), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 16/780268 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Heterocyclic Compounds C07D 473/16 (20130101) Original (OR) Class C07D 473/34 (20130101) C07D 487/04 (20130101) Peptides C07K 14/4738 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261559 | VLAAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PUERTO RICO (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cornelis P. VLAAR (San Juan, Puerto Rico); Suranganie DHARMAWARDHANE FLANAGAN (San Juan, Puerto Rico); Eliud HERNANDEZ-O'FARRILL (San Juan, Puerto Rico); Linette CASTILLO-PICHARDO (San Juan, Puerto Rico) |
| ABSTRACT | Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperproliferative and neoplastic diseases. Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in signaling pathways in cancer and metastasis. Methods for treatment of cancer and hyperproliferative diseases are disclosed. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/220319 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 403/14 (20130101) C07D 409/14 (20130101) C07D 491/048 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261563 | Ghosh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (, None) |
| INVENTOR(S) | Arun K. Ghosh (West Lafayette, Indiana); Hiroaki Mitsuya (Kumamoto, Japan); Prasanth Reddy Nyalapatla (Henrico, Virginia) |
| ABSTRACT | Various embodiments relate to a compound of the formula (I) and (II), wherein X, X1, X2, X3, and R1-R4 am defined herein, as well as pharmaceutical compositions comprising compounds of the formula (I) and/or (II) and methods of treating an HIV infection comprising administering a therapeutically effective amount of one or more compounds of formula (I) and/or (II), or a pharmaceutical composition comprising compounds of the formula (I) and/or (II), to a patient in need thereof. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307905 |
| CURRENT CPC | Heterocyclic Compounds C07D 311/78 (20130101) C07D 493/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261565 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); The Scripps Research Institute (Jupiter, Florida) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Mingji Dai (West Lafayette, Indiana); Dexter Cameron Davis (West Lafayette, Indiana); Alexander Adibekian (Palm, Florida); Dominic Gregor Hoch (Jupiter, Florida); Zhong-Yin Zhang (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging thugs for cancers. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/246775 |
| CURRENT CPC | Heterocyclic Compounds C07D 493/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261580 | DOWD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFI1 (WASHINGTON, District of Columbia); WASHINGTON UNIVERSITY (ST. LOUIS, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CYNTHIA DOWD (WASHINGTON, District of Columbia); AUDREY ODOM JOHN (ST. LOUIS, Missouri); RACHEL EDWARDS (ST. LOUIS, Missouri); KENNETH M. HEIDEL (WASHINGTON, District of Columbia); XU WANG (EXTON, Pennsylvania); RENE CHOFOR (WASHINGTON, District of Columbia) |
| ABSTRACT | The present disclosure provides method of treating or preventing a microbial infection caused by a prokaryotic pathogen in a subject, the method comprising administering a compound of Formula (I) as set forth in the specification. In one embodiment, the prokaryotic pathogen belongs to the genus Staphylococcus. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/253841 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/4009 (20130101) C07F 9/4015 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261583 | Edinger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Universite de Montreal (Montreal, Canada) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Universite de Montreal (Montreal, Canada) |
| INVENTOR(S) | Aimee Edinger (Irvine, California); Stephen Hanessian (Irvine, California) |
| ABSTRACT | Small molecules compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration. |
| FILED | Friday, June 14, 2019 |
| APPL NO | 17/252226 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 207/12 (20130101) C07D 487/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/572 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261602 | TONKS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COLD SPRING HARBOR LABORATORY (Cold Spring Harbor, New York); DEPYMED, INC. (Farmingdale, New York) |
| ASSIGNEE(S) | COLD SPRING HARBOR LABORATORY (Cold Spring Harbor, New York); DEPYMED, INC. (Farmingdale, New York) |
| INVENTOR(S) | Nicholas TONKS (Cold Spring Harbor, New York); Navasona KRISHNAN (Hawthorn Woods, Illinois); Andreas GRILL (Saint James, New York) |
| ABSTRACT | Compounds of formula:
|
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/261313 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/38 (20130101) C07D 401/12 (20130101) Steroids C07J 43/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261612 | Lam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Kit S. Lam (Davis, California); Ruiwu Liu (Sacramento, California); Wei Yao (El Dorado Hills, California); Nancy Lane (Hillsborough, California) |
| ABSTRACT | The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the α4β1 integrin on mesenchymal stem cells and for the surface of bone. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 16/997760 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/66 (20130101) A61K 31/661 (20130101) A61K 31/663 (20130101) A61K 35/28 (20130101) A61K 38/00 (20130101) A61K 38/06 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 47/64 (20170801) A61K 47/548 (20170801) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/02 (20130101) Peptides C07K 5/101 (20130101) C07K 5/0817 (20130101) C07K 5/0821 (20130101) Original (OR) Class C07K 5/1016 (20130101) C07K 5/1019 (20130101) C07K 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261617 | Lambris |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Lambris (Philadelphia, Pennsylvania) |
| ABSTRACT | Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. The compounds comprise compstatin analogs in which the N-terminus and/or C-terminus contains an added component that improves (1) the peptide's solubility at physiological pH; (2) the peptide's plasma half-life; (3) the peptide's intraocular retention; and/or (4) the peptide's binding affinity to C3 or its fragments as compared to an unmodified compstatin peptide under equivalent conditions. Pharmaceutical compositions and methods of using the compounds are also disclosed. |
| FILED | Friday, April 05, 2019 |
| APPL NO | 17/045018 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/60 (20170801) Peptides C07K 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261623 | Selsted et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael E. Selsted (Pasadena, California); Dat Q. Tran (Alhambra, California); Justin B. Schaal (Orange, California) |
| ABSTRACT | Uses of novel peptide analogs of a θ-defensin that have been developed which provide a biphasic effect in treating infection and/or sepsis are described. These analogs are active at concentrations below those needed to provide a bactericidal or bacteriostatic effect, and function by initially recruiting effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response characteristic of sepsis and septic shock. These novel θ-defensin analogs are protective at concentrations where naturally occurring θ-defensins have no apparent effect, and include a core set of structural and sequence features not found in native θ-defensin. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314473 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) Peptides C07K 7/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261643 | Fujinaga et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Koh Fujinaga (San Francisco, California); Boris Peterlin (San Francisco, California); Marie Leoz (Rouen, France) |
| ABSTRACT | Novel chimeric proteins may be used to inhibit transcriptional activities that are mediated by transcription factor interactions with P-TEFb. The chimeras contain elements that recruit the target transcription factor, maintain CDK9 in an inactive state, and competitively inhibit P-TEFb binding to the transcription factor. The chimeras may be configured for inhibition of HIV Tat mediated transcription and thus provide a novel means of preventing reactivation of integrated HIV, providing a new tool for emerging “block and lock” HIV cure strategies. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/220152 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/09 (20130101) C07K 2319/20 (20130101) C07K 2319/32 (20130101) C07K 2319/035 (20130101) C07K 2319/90 (20130101) C07K 2319/715 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261701 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado); UNIVERSITY OF NEW HAMPSHIRE (DURHAM, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JUNG-JAE LEE (AURORA, Colorado); KYUNG JAE JEONG (DURHAM, New Hampshire) |
| ABSTRACT | The present invention relates to the unexpected discovery of a cross-linked polymer of 2-hydroxyethyl methacrylate and dipicolylamine-containing monomers that can be used as a therapeutic lens to treat ocular diseases or disorders associated with matrix metalloproteinase (MMP) over-activity and/or over-expression, such as but not limited to corneal melting (or keratolysis). |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/256354 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0051 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Heterocyclic Compounds C07D 213/38 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 20/40 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) C08J 2333/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261739 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute Of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark E. Davis (Pasadena, California); Dorothy Pan (Pasadena, California) |
| ABSTRACT | The present disclosure is directed to nanoparticle delivery systems for delivering biological agents, pharmaceutical compositions of comprising these nanoparticles, and methods of using these compositions. Certain embodiments of the present disclosure provide nanoparticles comprising polymers comprising alternating charged and uncharged segments comprising one or more of the following structural units of Formula (I) Formula (III): wherein A is an uncharged segment comprising polyalkylene glycol; and B is a cationically charged segment comprising at least one polyhydroxy linkage. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308599 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5031 (20130101) A61K 47/34 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/40 (20130101) C08G 73/028 (20130101) C08G 79/08 (20130101) C08G 81/00 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261750 | Whang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyumin Whang (Helotes, Texas); Alexander Tribley (San Antonio, Texas); Benjamin R. Furman (San Antonio, Texas) |
| ABSTRACT | A composite includes a filler comprising boron nitride nanosheets (BNN) and a resin. The resin includes a multifunctional oxirane epoxy phenol novolac resin (EP8370), a multifunctional acrylate dipenta erythritol hexaacrylate (DPHA), 2-(perfluorooctyl)ethyl acrylate (PFOEA), urethane dimethacrylate (UDMA), and tetryhydrofuran (THF). Additional resins for use with the composite include bisphenol A glycidyl dimethacrylate (BisGMA), urethane dimethacrylate (UDMA), and/or triethylene glycol dimethacrylate (TEGDMA) in any combination thereof. |
| FILED | Saturday, April 27, 2019 |
| APPL NO | 17/255342 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/005 (20130101) C08J 3/28 (20130101) C08J 2333/16 (20130101) C08J 2335/02 (20130101) C08J 2363/04 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/38 (20130101) Original (OR) Class C08K 3/40 (20130101) C08K 5/08 (20130101) C08K 5/101 (20130101) C08K 2003/385 (20130101) C08K 2003/387 (20130101) C08K 2201/011 (20130101) Compositions of Macromolecular Compounds C08L 33/16 (20130101) C08L 35/02 (20130101) C08L 63/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261916 | Meissner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Torsten B. Meissner (Somerville, Massachusetts); Leonardo M.R. Ferreira (San Francisco, California); Jack L. Strominger (Cambridge, Massachusetts); Chad A. Cowan (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/148556 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) Original (OR) Class C12N 5/0696 (20130101) C12N 15/86 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2501/50 (20130101) C12N 2501/599 (20130101) C12N 2501/998 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261921 | Kheradvar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arash Kheradvar (Irvine, California); Paria Ali Pour (Irvine, California) |
| ABSTRACT | A method of altering energy metabolism in a recipient cell including: identifying the recipient cell as being in need of altering its oxidative phosphorylation status, obtaining exogenous mitochondria, and introducing into the recipient cell the exogenously obtained mitochondria, wherein the exogenously obtained mitochondria functions in the recipient cell to increase or decrease oxidative phosphorylation and/or glycolysis. Also disclosed are isolated cells that include an exogenous mitochondria, wherein the cell demonstrates increased energy metabolism compared to a control cell of the same type but wherein the control cell lacks exogenously added mitochondria. Also disclosed are methods of treating a subject suffering from ischemia or a mitochondrial dysfunction including administering one or more group of isolated cells including exogenous mitochondria as disclosed herein to the subject, wherein the one or more isolated cell including exogenous mitochondria improve symptoms of the ischemia or the mitochondrial dysfunction. |
| FILED | Tuesday, February 18, 2020 |
| APPL NO | 16/794115 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/34 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261923 | SLUKVIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Igor I. SLUKVIN (Verona, Wisconsin); Gene Uenishi (Madison, Wisconsin) |
| ABSTRACT | This invention discloses a method for the induction of arterial-type of hemogenic endothelium and method of differentiating T cells from hemogenic endothelial cells. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/233643 |
| CURRENT CPC | Peptides C07K 16/00 (20130101) C07K 16/28 (20130101) C07K 2317/52 (20130101) C07K 2319/30 (20130101) C07K 2319/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0647 (20130101) C12N 5/0691 (20130101) Original (OR) Class C12N 5/0696 (20130101) C12N 11/02 (20130101) C12N 2500/99 (20130101) C12N 2501/42 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2533/50 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261925 | Sherman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David H. Sherman (Ann Arbor, Michigan); Amy E. Fraley (Ann Arbor, Michigan); Ashootosh Tripathi (Ypsilanti, Michigan) |
| ABSTRACT | The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228211 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4995 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/182 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261930 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Quan Lu (Cambridge, Massachusetts); Qiyu Wang (Cambridge, Massachusetts); Stanley N. Cohen (Palo Alto, California) |
| ABSTRACT | Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168808 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 47/6455 (20170801) Peptides C07K 7/06 (20130101) C07K 14/4718 (20130101) C07K 2319/00 (20130101) C07K 2319/01 (20130101) C07K 2319/03 (20130101) C07K 2319/70 (20130101) C07K 2319/85 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) Original (OR) Class C12N 9/22 (20130101) C12N 9/93 (20130101) C12N 2810/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261932 | Kleinstiver et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Kleinstiver (Medford, Massachusetts); Russell T. Walton (Waban, Massachusetts) |
| ABSTRACT | Engineered versions of Streptococcus pyogenes Cas9 (SpCas9) and SpCas9 variants that have improved on-target editing capabilities, and methods of use thereof. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157805 |
| CURRENT CPC | Peptides C07K 2319/71 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) C12N 9/1007 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261938 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Flarvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Flarvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Tina Wang (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure relate to strategies, systems, methods, compositions, and kits that are useful for production (e.g., evolution) of cytidine deaminase protein variants that are characterized by increased soluble expression and/or stability relative to the wild-type cytidine deaminase protein from which they are evolved. In some embodiments, evolved cytidine deaminase variants described by the disclosure are useful for incorporation into targeted nucleic acid editing proteins, for example in fusion proteins with a Cas9 domain or variant thereof. |
| FILED | Friday, June 14, 2019 |
| APPL NO | 17/251276 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) Original (OR) Class Enzymes C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261943 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl Hirschie Johnson (Nashville, Tennessee); Philip D. Weyman (Cardiff, California); Qing Xu (North Potomac, Maryland); Yao Xu (Nashville, Tennessee) |
| ABSTRACT | A method of increasing gene expression by manipulating the circadian clock is described that includes transforming a photosynthetic organism to include an expression control sequence that modulates the expression of a clock gene to increase expression of a target gene. Photosynthetic organism having a modified circadian cycle reflecting this method are also described. |
| FILED | Sunday, February 21, 2021 |
| APPL NO | 17/180816 |
| CURRENT CPC | Peptides C07K 14/62 (20130101) C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0067 (20130101) C12N 15/00 (20130101) Original (OR) Class C12N 15/74 (20130101) C12N 15/8222 (20130101) Enzymes C12Y 112/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261946 | SCHARENBERG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SEATTLE CHILDREN'S HOSPITAL (dba SEATTLE CHILDREN'S RESEARCH INSTITUTE) (Seattle, Washington) |
| ASSIGNEE(S) | SEATTLE CHILDREN'S HOSPITAL (dba SEATTLE CHILDREN'S RESEARCH INSTITUTE) (Seattle, Washington) |
| INVENTOR(S) | Andrew M. SCHARENBERG (Seattle, Washington); Michael T. CERTO (Seattle, Washington); Kamila Sabina GWIAZDA (Seattle, Washington) |
| ABSTRACT | The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244190 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/28 (20130101) A61K 38/45 (20130101) A61K 38/52 (20130101) A61K 38/465 (20130101) A61K 2035/124 (20130101) Peptides C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/90 (20130101) C12N 9/1252 (20130101) C12N 15/62 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 2800/80 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261962 | MIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Yi-Li MIN (Dallas, Texas); Rhonda BASSEL-DUBY (Dallas, Texas); Eric OLSON (Dallas, Texas) |
| ABSTRACT | Duchenne muscular dystrophy (DMD), which affects 1 in 5,000 male births, is one of the most common genetic disorders of children. This disease is caused by an absence or deficiency of dystrophin protein in striated muscle. The major DMD deletion “hot spots” are found between exon 6 to 8, and exons 45 to 53. Here, three DMD mouse models are provided that can be used to test a variety of DMD exon skipping and refraining strategies. Among these are, CRISPR/Cas9 oligonucleotides, small molecules or other therapeutic modalities that promote exon skipping or exon refraining or micro dystrophin mini genes or cell based therapies. Methods for restoring the reading frame of exon 43, exon 45, and exon 52 deletion via CRISPR-mediated exon skipping and refraining in the humanized DMD mouse model, in patient-derived iPSCs and ultimately, in patients using various delivery systems are also contemplated. The impact of CRISPR technology on DMD is that gene editing can permanently correct mutations. |
| FILED | Friday, June 21, 2019 |
| APPL NO | 17/253606 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 29/005 (20130101) A01K 2207/05 (20130101) A01K 2217/206 (20130101) A01K 2227/105 (20130101) A01K 2267/0306 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2320/33 (20130101) C12N 2750/14143 (20130101) C12N 2830/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261967 | Bhandari |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vineet Bhandari (, None) |
| ASSIGNEE(S) | Vineet Bhandari (Lansdale, Pennsylvania) |
| INVENTOR(S) | Vineet Bhandari (Lansdale, Pennsylvania) |
| ABSTRACT | The present invention provides compositions and methods for delivery to a lung tissue comprising a small interfering RNA (siRNA) capable of inhibiting expression of a gene, and a surfactant. In one aspect, a non-polymeric methods composition comprising a small interfering RNA (siRNA) capable of inhibiting expression of a gene, and a surfactant is disclosed. In other aspects, a method of inhibiting gene expression in a lung of a subject in need thereof and treating bronchopulmonary dysplasia in a lung of a subject also disclosed. The methods comprise administering a therapeutically effective amount of a non-polymeric composition to the lung of the subject, wherein the non-polymeric composition comprises a small interfering RNA (siRNA) capable of inhibiting expression of a gene, and a surfactant. |
| FILED | Tuesday, May 26, 2020 |
| APPL NO | 16/883667 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0073 (20130101) A61K 31/713 (20130101) A61K 45/06 (20130101) A61K 47/24 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/1136 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261970 | Arora |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rishi Arora (Chicago, Illinois) |
| ABSTRACT | Disclosed herein are pharmaceutical compositions and methods for inhibiting oxidative stress in a subject having atrial or ventricular arrhythmias, ventricular failure or heart failure. The methods include administering an effective amount of a NOX2 inhibitor agent to the subject, wherein said administering is under conditions such that a level of oxidative stress in myocardial tissue is reduced or eliminated. The pharmaceutical compositions include a NOX2 inhibitor agent. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240659 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/316 (20210101) A61B 5/361 (20210101) A61B 5/4848 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/531 (20130101) Enzymes C12Y 106/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261971 | DE LEVE |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laurie D. DE LEVE (Los Angeles, California) |
| ABSTRACT | In alternative embodiments, provided are compositions, including pharmaceutical compositions and formulations, products of manufacture and kits, and methods, for: enhancing or accelerating liver regeneration, optionally enhancing or accelerating liver regeneration after tissue injury or liver resection; enhancing or accelerating tissue repair, optionally enhancing or accelerating tissue repair after a trauma, an injury or an infection, wherein optionally the injury is an ischemia-reperfusion injury comprising: administering to an individual in need thereof, a compound or composition capable of inhibiting or decreasing the expression or activity of a matrix metalloproteinase (MMP) in a tissue-specific or tissue-selective manner, in in an end organ specific manner, or administering to the organ, for example, a liver, of an individual in need thereof a compound or composition capable of inhibiting or decreasing the expression or activity of a matrix metallo-proteinase. |
| FILED | Tuesday, June 25, 2019 |
| APPL NO | 17/254194 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 9/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262006 | Seyfried et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Seyfried (Atlanta, Georgia); Duc Duong (Decatur, Georgia); Allan Levey (Atlanta, Georgia); Maotian Zhou (Atlanta, Georgia); James Lah (Avondale Estates, Georgia) |
| ABSTRACT | This disclosure relates to isotopically labeled internal standards that can be digested by an enzyme capable of C-terminal cleavage of a first amino acid and/or an enzyme capable of N-terminal cleavage of a second amino acid useful to generate standards for the measurement of quantities of peptides of interest in a sample. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/254032 |
| CURRENT CPC | Peptides C07K 14/4711 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/6896 (20130101) G01N 2800/2814 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262011 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Jehyuk Lee (Allston, Massachusetts); Daniel Levner (Boston, Massachusetts); Michael Super (Lexington, Massachusetts) |
| ABSTRACT | Methods of making a three-dimensional matrix of nucleic acids within a cell is provided. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238642 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262017 | HARVEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Jackson HARVEY (New York, New York); Daniel HELLER (New York, New York); Prakrit JENA (New York, New York) |
| ABSTRACT | Described herein are novel devices and methods for the optical detection of oligonucleotide binding events for diagnostic, point-of-care, drug screening, and theranostic applications, for example, a robust and customizable system to detect specific DNA and RNA oligonucleotides using a carbon nanotube optical signal. |
| FILED | Thursday, August 20, 2020 |
| APPL NO | 16/998762 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6834 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262022 | Kathiresan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sekar Kathiresan (Boston, Massachusetts); Connor Emdin (Boston, Massachusetts) |
| ABSTRACT | Described herein are MARC variants that associate with a risk of liver diseases or a symptom(s) thereof, such as cirrhosis, or protection against such liver diseases or symptom(s) thereof. Also described herein are compositions and formulations that can be capable of modulating MARC in a subject and/or treatment of a liver disease or a symptom thereof. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 16/807125 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262025 | Bhatia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Sangeeta N. Bhatia (Lexington, Massachusetts); Liangliang Hao (Cambridge, Massachusetts); Renee Zhao (Los Angeles, California); Chayanon Ngambenjawong (Cambridge, Massachusetts) |
| ABSTRACT | Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of environmental triggers (e.g., enzyme activity, pH or temperature). In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of modified nucleic acid barcodes as representative of the presence of active enzymes (e.g., proteases) associated with a disease, for example, cancer. In some embodiments, the disclosure provides compositions and methods for production of in vivo sensors comprising modified nucleic acid barcodes. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/124999 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262039 | Hacohen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nir Hacohen (Brookline, Massachusetts); Michael S. Rooney (Cambridge, Massachusetts) |
| ABSTRACT | In one aspect, provided herein is a method comprising: (a) (i) determining cytolytic activity in a tumor from the subject; and/or (ii) determining genetic alterations associated with cytolytic activity in the tumor; and (b) administering an immunotherapeutic agent to the subject if (i) cytolytic activity is detected in the tumor and/or (ii) a genetic alteration associated with induction of cytolytic activity, tumor resistance to cytolytic activity and/or suppression of cytolytic activity is detected in the tumor. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/179956 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) G01N 2333/96436 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262906 | Hewitt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Michael Oshetski (Horseheads, New York); The USA as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The USA as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Stephen M. Hewitt (Bethesda, Maryland); Jeffrey C. Hanson (Bethesda, Maryland); Kris R. Ylaya (Bethesda, Maryland); Michael Oshetski (Horseheads, New York) |
| ABSTRACT | An article comprising: a planar base having a first surface and an opposing second surface and an outer peripheral edge, wherein the second surface includes an area comprising a plurality of protuberances and configured to attach and maintain orientation of a frozen tissue specimen block; and a removable lid having a first side and a second side, wherein the first side defines a continuous planar surface and the second side defines a recessed portion configured to cover a frozen tissue specimen block and an outer rim configured to engage with the outer peripheral edge of the base, wherein the outer rim does not form part of the recessed portion, wherein the area of the base and the recessed portion of the lid are aligned. |
| FILED | Friday, September 29, 2017 |
| APPL NO | 16/338860 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/508 (20130101) B01L 2300/041 (20130101) B01L 2300/0609 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/36 (20130101) Original (OR) Class G01N 1/42 (20130101) G01N 2001/315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262930 | Simpson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Garth Jason Simpson (Lafayette, Indiana); Fengyuan Deng (Watertown, Massachusetts); Changqin Ding (West Lafayette, Indiana); Chen Li (West Lafayette, Indiana) |
| ABSTRACT | A system including a first micro-retarder array, wherein the first micro-retarder array is configured to convert a purely polarized light of an incident light into two components. The system additionally includes an optical device, wherein the optical device is configured to collimate the two components to two foci planes. Moreover, the system includes a second micro-retarder array, wherein the second micro-retarder array is configured to combine a set of two components of the incident light, thereby producing a second purely polarized light. Further the system includes a detector, wherein the detector is configured to receive the second purely polarized light. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/239683 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Original (OR) Class G01N 2201/0633 (20130101) Optical Elements, Systems, or Apparatus G02B 5/3016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263012 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ana C. Anderson (Boston, Massachusetts); Vijay K. Kuchroo (Boston, Massachusetts); Meromit Singer (Cambridge, Massachusetts); Aviv Regev (Cambridge, Massachusetts) |
| ABSTRACT | The subject matter disclosed herein is generally directed to novel CD8+ and CD4+ T cell subtypes associated with effector, suppressive or regulatory T cell functions. Moreover, the subject matter disclosed herein is generally directed to methods and compositions for use of the subtype. Also, disclosed herein are gene signatures and markers associated with the subtype and use of said signatures and markers. Further disclosed are therapeutic methods of using said gene signatures and immune cell subtype. Further disclosed are pharmaceutical compositions comprising populations of CD4+ and/or CD8+ TILs or populations of immune cells depleted for a specific subtype. Further disclosed are interactions with other T cell subtypes. |
| FILED | Monday, November 19, 2018 |
| APPL NO | 16/764506 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) Original (OR) Class G01N 33/5091 (20130101) G01N 2333/7051 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263013 | Ezzelarab et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Mohamed B. Ezzelarab (Pittsburgh, Pennsylvania); Angus W. Thomson (Pittsburgh, Pennsylvania) |
| ABSTRACT | Pre-existing alloreactive memory T cells are a major barrier to the induction of allograft tolerance in organ transplant recipients. The use of Eomesodermin (Eomes) expression in memory T cells to determine the risk of allograft rejection in a subject is described. Also described is the use of Eomes expression in memory T cells of transplant recipients to modify immunosuppressive therapy. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245716 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) Original (OR) Class G01N 2333/4703 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263014 | Klebba et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Phillip E. Klebba (Manhattan, Kansas); Somnath Chakravorty (Buffalo, New York); Yan Shipelskiy (Holland, Pennsylvania); Salete M. Newton (Manhattan, Kansas); Ashish Kumar (Manhattan, Kansas) |
| ABSTRACT | A universal bacterial assay and kit for detecting and monitoring changes in concentration of a target analyte in solution. The assay relies on an engineered high affinity protein-based sensor with a detectable label that has high specificity to a target analyte, typically a ligand or metallated complex, and can be used to spectroscopically monitor interaction of the target analyte with a test bacterial strain. The sensors can be in the form of living, transport-deficient bacterial cells expressing the engineered high affinity protein, or in the form of purified proteins themselves. The system can further be used to screen candidate compounds for interference with the binding and uptake of such analytes by bacterial cells, which is useful in investigation of new classes of antibiotics. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/253412 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) Original (OR) Class G01N 33/54366 (20130101) G01N 2333/795 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263021 | Fu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dax Fu (Short Hills, New Jersey) |
| ABSTRACT | The present invention describes methods of identifying drugs for the treatment or prevention of diabetes by measuring the activity of the human zinc transporter ZnT8 and pharmaceutical compositions. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242938 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 31/56 (20130101) A61K 31/6615 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5432 (20130101) Original (OR) Class G01N 33/6893 (20130101) G01N 33/57407 (20130101) G01N 33/57434 (20130101) G01N 2800/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263033 | Bedi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tuskegee University (Tuskegee, Alabama) |
| ASSIGNEE(S) | Tuskegee University (Tuskegee, Alabama) |
| INVENTOR(S) | Deepa Bedi (Tuskegee, Alabama); Kelvin Jones (Tuskegee, Alabama) |
| ABSTRACT | There is disclosed a method for selectively detecting epithelial to mesenchymal transition (EMT) phenotypic cells but not noncancerous/normal epithelial cells and breast fibroblasts in a biological sample or a patient. The compositions comprise novel binding peptides that specifically bind to EMT cancer cells. EMT phenotypic cells can be identified using the specific peptides and quantitatively measured by detection of a complex of the peptide and a detectable marker. Further, nanodevices incorporating specific EMT phage ligand may be used to identify EMT cancer cells in vivo. Also disclosed are the novel binding phage peptides, and compositions and nanodevices containing the phage ligand for carrying out methods of the invention. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/125657 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) Peptides C07K 7/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263035 | Norton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Larry Norton (New York, New York); Ross Levine (New York, New York); Maria Kleppe (New York, New York); Elizabeth Comen (New York, New York) |
| ABSTRACT | Provided herein are methods of treating a nonhematopoietic malignant tumor in a patient and methods of prognosing a nonhematopoietic malignant tumor in a patient, comprising administering to the patient a therapeutically effective amount of an agent that preferentially kills or inhibits proliferation or activity of leukocytes relative to nonhematopoietic cells. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207412 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/52 (20130101) A61K 31/506 (20130101) A61K 31/573 (20130101) A61K 31/704 (20130101) A61K 31/7048 (20130101) A61K 31/7052 (20130101) A61K 31/7068 (20130101) A61K 38/177 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) Original (OR) Class G01N 33/57496 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263047 | COUGHLIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SEQUELA, INC. (Pewee Valley, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard T. COUGHLIN (Falmouth, Maine); Stephen L. CARRITHERS (Pewee Valley, Kentucky); Aaron L. CARRITHERS (Pewee Valley, Kentucky); Brennan M. CARRITHERS (Pewee Valley, Kentucky) |
| ABSTRACT | The levels of prouroguanylin (proUGN), or fragments thereof, present in blood are normally low in humans and are proposed to be involved in the physiologic regulation of oral and vascular salt levels in the body. When certain kidney related diseases or kidney dysfunctions occur, the level of proUGN or fragments thereof can rise dramatically and significantly. This rise of proUGN in the serum can be used as a marker to diagnose and, in turn, treat kidney disease, or monitor disease progression of kidney dysfunction, or can be used to predict the outcome of a treatment program for kidney disease and/or dysfunction. The level of proUGN or fragments thereof can be measured by a novel immunological assay, and a positive result above a cut-off value is diagnostic for chronic kidney disease (CKD). The calibration of that immunological assay can be done best by using a full-length appropriately folded and secreted recombinant human protein without any N′- or C′-terminal tags made in a human kidney cell line. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/160661 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263054 | KOBAYASHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SHIMADZU CORPORATION (Kyoto-shi, Kyoto, Japan); THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| ASSIGNEE(S) | SHIMADZU CORPORATION (Kyoto-shi, Kyoto, Japan); THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| INVENTOR(S) | Hisataka KOBAYASHI (Bethesda, Maryland); Masayuki NISHIMURA (Columbia, Maryland) |
| ABSTRACT | A method and treatment for testing efficiency and effectiveness of a near infrared photoimmunotherapy treatment includes injecting an antibody photosensitizer conjugate (APC) into a patient, applying radiation to the patient, thereby causing the APC to release a ligand, which is excreted in the patients urine, detecting the presence of the ligand with liquid chromatography-mass spectrometry, measuring and quantifying an amount of the ligand present in the patients urine based on analytical results of the liquid chromatography-mass spectrometry, and determining the effectiveness of the near infrared photo-immunotherapy treatment based on the measured quantified amount of the ligand present in the patients urine so as to determine an amount of APC remaining in the patient. |
| FILED | Thursday, June 20, 2019 |
| APPL NO | 17/253671 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0042 (20130101) A61K 41/0071 (20130101) A61K 47/6849 (20170801) A61K 47/6855 (20170801) Peptides C07K 16/2863 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) Original (OR) Class G01N 33/6848 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263170 | Adler |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| INVENTOR(S) | Stephen S. Adler (Chevy Chase, Maryland) |
| ABSTRACT | Methods and apparatus for calibrating radioactive sources are described. An array of scintillation detectors form a receptacle within which a sample or sample container can be retained by a holder. The scintillation detectors are coupled via light transducers such as photomultiplier tubes (PMTs) to independent electronic counters. Coincidence processing of time-tagged events yields a correlated cent rate. One or more corrections can be applied as needed, for background counts, deadtime, or random coincidences. Voltage tuning of PMTs yields improved reproducibility. Variations are disclosed. 1% accuracy has been demonstrated over a range N of 10 kBq-3 MBq, covering a gap in the capabilities of conventional technology. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314355 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/167 (20130101) Original (OR) Class G01T 1/2006 (20130101) G01T 1/2023 (20130101) G01T 7/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264152 | Smalt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Smalt (Arlington, Massachusetts); Gregory Ciccarelli (Cambridge, Massachusetts); William Murphy (Cincinnati, Ohio) |
| ABSTRACT | In some embodiments, a method for enforcing hearing protection safety compliance can include: obtaining one or more images of an ear of a user; preprocessing the one or more images to localize the user's ear and/or a hearing protection device (HPD) worn thereabout; providing the one or more preprocessed images to a classification network; receiving an estimated attenuation value as output of the classification network, the estimated attenuation value corresponding to an estimate of the noise attenuation provided by the HPD work about the user's ear; and automatically enforcing compliance with a safety standard using the estimated noise attenuation value. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 16/797554 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00281 (20130101) G06K 9/00671 (20130101) Original (OR) Class G06K 9/6267 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) Image Data Processing or Generation, in General G06T 3/0006 (20130101) G06T 3/60 (20130101) G06T 7/11 (20170101) G06T 7/70 (20170101) G06T 2207/20132 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/02 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264346 | Momayez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona board of regents on behalf of the university of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Moe Momayez (Tucson, Arizona); Mary M. Poulton (Mead, Washington) |
| ABSTRACT | A worksite safety system and method is disclosed. The system uses wearable sensors to collect biometric data from workers. The data are used to compute a worker's core body temperature on the basis of an individual profile associating historical biometric data with measured core body temperature. If the computed core body temperature crosses certain thresholds, alert actions are performed. |
| FILED | Thursday, October 25, 2018 |
| APPL NO | 16/759297 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02 (20130101) Electric Digital Data Processing G06F 1/163 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6257 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/063114 (20130101) G06Q 10/063116 (20130101) Original (OR) Class G06Q 50/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210265043 | Haghighi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fatemeh Haghighi (Tempe, Arizona); Mohammad Reza Hosseinzadeh Taher (Tempe, Arizona); Zongwei Zhou (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Described herein are means for learning semantics-enriched representations via self-discovery, self-classification, and self-restoration in the context of medical imaging. Embodiments include the training of deep models to learn semantically enriched visual representation by self-discovery, self-classification, and self-restoration of the anatomy underneath medical images, resulting in a collection of semantics-enriched pre-trained models, called Semantic Genesis. Other related embodiments are disclosed. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180575 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/55 (20190101) G06F 16/583 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6255 (20130101) G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 30/40 (20180101) Original (OR) Class G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210266686 | PURIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Earlens Corporation (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunil PURIA (Boston, Massachusetts); Micha ROSEN (Tzur Hadassah, Israel); Jonathan P. FAY (Dexter, Michigan); Paul RUCKER (San Francisco, California); James STONE (Saratoga, California) |
| ABSTRACT | A device to transmit an audio signal to a user comprises a transducer and a support. The support is configured for placement on the eardrum to drive the eardrum. The transducer is coupled to the support at a first location to decrease occlusion and a second location to drive the eardrum. The transducer may comprise one or more of an electromagnetic balanced armature transducer, a piezoelectric transducer, a magnetostrictive transducer, a photostrictive transducer, or a coil and magnet. The device may find use with open canal hearing aids. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/243497 |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 11/02 (20130101) H04R 17/00 (20130101) H04R 23/008 (20130101) H04R 25/02 (20130101) H04R 25/65 (20130101) H04R 25/554 (20130101) H04R 25/606 (20130101) Original (OR) Class H04R 25/652 (20130101) H04R 2225/025 (20130101) H04R 2460/09 (20130101) H04R 2460/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210259241 | Pomahac et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bohdan Pomahac (Boston, Massachusetts); Maximilian Keuckelhaus (Boston, Massachusetts) |
| ABSTRACT | Systems and methods to perfuse isolated tissue are provided to avoid ischemia-related tissue damage over an extended perfusion time is provided. A system can comprise a reservoir sized and dimensioned to contain a perfusate. A perfusion supply line can comprise a pump, a cooling system, an oxygenator, and at least one filter. The perfusion supply line can be in fluid communication with the reservoir to draw the perfusate from the reservoir and cool and oxygenate the perfusate. The system can also include an arterial line in fluid communication with the perfusion supply line to direct perfusate from the reservoir to the isolated tissue. A venous outflow can be in fluid communication with the isolated tissue to remove the perfusate from the isolated tissue. A perfusion return line can be in fluid communication with the venous outflow to return the perfusate from the isolated tissue to the reservoir. |
| FILED | Wednesday, April 17, 2019 |
| APPL NO | 17/253741 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/021 (20130101) A01N 1/0247 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210259585 | GALAGAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | James GALAGAN (Needham, Massachusetts); Mark W. GRINSTAFF (Brookline, Massachusetts); Uros KUZMANOVIC (Brookline, Massachusetts); Mingfu CHEN (Boston, Massachusetts); Margarita Alexandrovna TARARINA (Bryn Mawr, Pennsylvania); Karen Nazaretian ALLEN (Weston, Massachusetts) |
| ABSTRACT | Described herein is an amperometric biosensor, e.g., chronoamperometric biosensor for the measurement of the concentration of nicotine. Also disclosed herein is a wearable nicotine biosensor device and a biosensor that detects nicotine in smoke. The biosensor disclosed herein comprises a nicotine-catalyzing enzyme, such as NicA2 or mutant NicA2 enzymes. Also described herein are systems comprising said amperometric biosensor, e.g., chronoamperometric biosensor and methods of using said chronoamperometric biosensor. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/169193 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1486 (20130101) Original (OR) Class A61B 5/4845 (20130101) A61B 5/14517 (20130101) A61B 10/0064 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/004 (20130101) C12Q 1/005 (20130101) C12Q 1/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3272 (20130101) G01N 33/48714 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210259665 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | The Government of the United States as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| INVENTOR(S) | Shane B. Anderson (Salt Lake City, Utah); Lorne H. Blackbourne (Austin, Texas); Mariya Gusman (St. Louis, Missouri); Jose Salinas (San Antonio, Texas) |
| ABSTRACT | An embodiment of the invention provides a method to measure fluid within a body cavity where data is received with an interface 210, the data being received from an ultrasound transducer. A three-dimensional sonographic image is generated with an image generator 220 connected to the interface 210, the three-dimensional sonographic image being generated from the data received from the ultrasound transducer. The body cavity is identified in the three-dimensional sonographic image with an image processor 230 connected to the image generator 220; and, an area of fluid in the body cavity in the three-dimensional sonographic image is identified with the image processor 230. The volume of the area of fluid is calculated using the three-dimensional sonographic image and a stacked crescents process, a spherical fill process, a convex hull process, and/or a triangulation process. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/315096 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/466 (20130101) A61B 8/483 (20130101) Original (OR) Class A61B 8/5223 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210259954 | Pala et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chapman University (Orange, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajasekharreddy Pala (Orange, California); Surya M. Nauli (Orange, California) |
| ABSTRACT | Disclosed herein are cilia-targeting nanoparticles and methods of treating ciliopathies. |
| FILED | Friday, November 27, 2020 |
| APPL NO | 17/105949 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) Original (OR) Class A61K 9/5015 (20130101) A61K 9/5031 (20130101) A61K 9/5115 (20130101) A61K 9/5153 (20130101) A61K 31/55 (20130101) A61K 39/39533 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) Peptides C07K 16/286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260043 | Braunschweig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York); Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam B. Braunschweig (New York, New York); Kalanidhi Palanichamy (Harrison, New Jersey); M. Fernando Bravo (New York, New York); Milan A. Shlain (Brooklyn, New York); Himanshu Garg (El Paso, Texas); Anjali Joshi (El Paso, Texas); Khushabu Thakur (New York, New York) |
| ABSTRACT | Compounds with anti-viral properties are provided that are based on the following structures: A variety of heteroaromatic groups have been found to be biologically active against viral infections. In some embodiments, a dimeric compound is provided with each monomer linked by a repeating glycol linking group. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314560 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4192 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260092 | MILLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | New York University (New York, New York) |
| INVENTOR(S) | George MILLER (Englewood, New Jersey); Berk AYKUT (Brooklyn, New York); Deepak SAXENA (New York, New York); Smruti PUSHALKAR (New York, New York) |
| ABSTRACT | The application relates to methods based on modulating pancreatic and/or gastrointestinal microbiota and related antifungal compositions. Specifically, the application relates to the use of microbiome for prevention, treatment and diagnosis of pancreatic cancers or tumors, such as pancreatic ductal adenocarcinoma. |
| FILED | Wednesday, September 30, 2020 |
| APPL NO | 17/038813 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7048 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260128 | Friedman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Alan D. Friedman (Baltimore, Maryland) |
| ABSTRACT | The present invention provides methods for making autologous bone marrow hematopoietic progenitors lacking NF-κB p50 protein subunit (p50). The progenitor cells are expanded, exposed to a myeloid cytokine, and provided intravenously to treat various malignancies. The infused cells have the potential to generate mature granulocytes, monocytes, macrophages, and dendritic cells that are activated due to the absence of p50. Methods for the genetically manipulation of a subject's hematopoietic progenitors during the expansion phase to reduce or eliminate p50 expression are also contemplated, and these progenitor cells may be combined with other therapeutic agents to maximize efficacy. |
| FILED | Monday, November 30, 2020 |
| APPL NO | 17/106893 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 15/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260176 | Aguiar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland) |
| ASSIGNEE(S) | United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland) |
| INVENTOR(S) | Joao Carlos Aguiar (Potomac, Maryland); Keith Limbach (Gaithersburg, Maryland); Emily Smith (Silver Spring, Maryland) |
| ABSTRACT | The present invention provides methods and compositions for immunizing a subject against malaria. |
| FILED | Friday, March 30, 2018 |
| APPL NO | 16/497244 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260202 | Fukuda et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sanford-Burnham Medical Research Institute (La Jolla, California); Hamamatsu University School of Medicine (Higashi-ku, Japan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michiko Fukuda (La Jolla, California); Kazuhiro Sugihara (Higashi-ku, Japan); Naohira Kanayama (Higashi-ku, Japan) |
| ABSTRACT | Compositions and methods related to annexin 1-binding compounds. Also compositions comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Isolated nucleic acids comprising a nucleic acid sequence encoding a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods comprising administering to a subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods of targeting a tumor cell in a subject comprising administering to the subject a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods of targeting a tumor cell in a subject comprising administering to the subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240714 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260364 | Asbeck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brown University (Providence, Rhode Island); UNIVERSITY OF CALIFORNIA, SAN DIEGO (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Michael Asbeck (Del Mar, California); Farah Laiwalla (Barrington, Rhode Island); Vincent Wingching Leung (San Diego, California); Jihun Lee (Providence, Rhode Island); Lawrence Ernest Larson (Providence, Rhode Island); Patrick Mercier (San Diego, California); Arto Nurmikko (Providence, Rhode Island); Ramesh Rao (La Jolla, California) |
| ABSTRACT | A system includes an implanted autonomous microchiplet communicatively linked to an epidermal skinpatch having a transceiver and a demodulator, an intermediate device communicatively linked to the epidermal skinpatch, the intermediate device configured to receive neural signals for decoding from the epidermal skinpatch and to send encoded signals for patterned stimulation to the epidermal skinpatch, and one or more external devices communicatively linked to intermediate device. |
| FILED | Tuesday, July 16, 2019 |
| APPL NO | 17/260903 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0529 (20130101) Original (OR) Class A61N 1/3787 (20130101) A61N 1/36125 (20130101) A61N 1/37229 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260562 | SHAIKH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | XPLOSAFE, LLC (Stillwater, Oklahoma) |
| ASSIGNEE(S) | XPLOSAFE, LLC (Stillwater, Oklahoma) |
| INVENTOR(S) | Shoaib F. SHAIKH (Stillwater, Oklahoma); Allen W. APBLETT (Stillwater, Oklahoma); Nicholas F. MATERER (Stillwater, Oklahoma); Evgueni KADOSSOV (Stillwater, Oklahoma); Michael L. TEICHEIRA (Stillwater, Oklahoma) |
| ABSTRACT | The present invention provides an improved sorbent and corresponding device(s) and uses thereof for the capture and stabilization of volatile organic compounds (VOC) or semi-volatile organic compounds (SVOC) from a gaseous atmosphere. The sorbent is capable of rapid and high uptake of one or more compounds and provides quantitative release (recovery) of the compound(s) when exposed to elevated temperature and/or organic solvent. Uses of particular improved grades of mesoporous silica are disclosed. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157526 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/106 (20130101) B01D 2257/708 (20130101) B01D 2259/4583 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) Original (OR) Class B01J 20/3204 (20130101) B01J 20/3219 (20130101) B01J 20/3246 (20130101) B01J 20/3293 (20130101) B01J 20/28021 (20130101) B01J 20/28064 (20130101) B01J 20/28073 (20130101) B01J 20/28076 (20130101) B01J 20/28083 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/18 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2004/04 (20130101) C01P 2004/13 (20130101) C01P 2006/12 (20130101) C01P 2006/14 (20130101) C01P 2006/16 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/0091 (20130101) C06B 23/00 (20130101) C06B 45/00 (20130101) Blasting F42D 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260939 | Bales et al. |
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| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Bales (Beavercreek, Ohio); Thomas G. Benner (Beavercreek, Ohio); Stuart P. Baker (Dayton, Ohio); Brent J. Young (Fairborn, Ohio) |
| ABSTRACT | A tire change tool comprising a generally circular and planar faceplate having a hub side and a user side, the hub side and user side being generally parallel; an upper elbow flexibly connected to the faceplate by an interface; an arm connected to the upper elbow at a first end, and connected to a lower elbow at a lower end; and a footplate flexibly connected to the lower end of the arm by the lower elbow, wherein the faceplate and the interface comprise co-aligned apertures, the co-aligned apertures having an axis perpendicular to the plane of the faceplate. A length adjustment mechanism may be incorporated into the arm and adapted to permit the arm's length to be changed. The arm may include an upper section and a lower section adjustable connected by an adjustment mechanism adapted to permit the arm's length to be changed. |
| FILED | Wednesday, February 26, 2020 |
| APPL NO | 16/801219 |
| CURRENT CPC | Vehicle Tyres Tyre Inflation; Tyre Changing or Repairing; Repairing, or Connecting Valves To, Inflatable Elastic Bodies in General; Devices or Arrangements Related to Tyres B60C 25/025 (20130101) Original (OR) Class Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/40 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261024 | EVANS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRATT and MILLER ENGINEERING AND FABRICATION, INC. (New Hudson, Michigan) |
| ASSIGNEE(S) | PRATT and MILLER ENGINEERING AND FABRICATION, INC. (New Hudson, Michigan) |
| INVENTOR(S) | CELYN M. EVANS (MILFORD, Michigan); KEVIN R. KWIATKOWSKI (ANN ARBOR, Michigan) |
| ABSTRACT | A seat having a seat back pivotally connected to a seat pan, the seat back and the seat pan independently pivotal. At the pivot between the seat back and the seat pan there is a rotary energy attenuation device. The rotary energy attenuating device cooperates with a track system along the length of seat longitudinal members allowing for different directions of travel and height adjustment. The vehicle seat offers passive or active protection from impact and sudden acceleration due to accident or explosive events and is capable of automatically resetting. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/243013 |
| CURRENT CPC | Seats Specially Adapted for Vehicles; Vehicle Passenger Accommodation Not Otherwise Provided for B60N 2/4214 (20130101) B60N 2/42745 (20130101) Original (OR) Class B60N 2/42772 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261504 | Edinger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Université de Montréal (Montreal, Canada) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); The Université de Montréal (Montreal, Canada) |
| INVENTOR(S) | Aimee L. Edinger (Irvine, California); Stephen Hanessian (Irvine, California) |
| ABSTRACT | Small molecules comprised of azacyclic constrained sphingolipid-like compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/195556 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 207/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261721 | Kosinski et al. |
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| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | Zymergen Inc. (Emeryville, California) |
| INVENTOR(S) | Szymon Kosinski (San Francisco, California); Stephen Lo (San Francisco, California); Timothy Mauldin (Cupertino, California); Shilpa Naresh Raja (Emeryville, California); Nicole G. Ricapito (Greenwhich, New York); Adam Safir (Berkeley, California) |
| ABSTRACT | An epoxy resin composition comprises about 70 wt % to about 95 wt % by weight of the composition of an epoxy component; and a curing component comprising about 5 wt % to about 30 wt % by weight of the composition, wherein the curing component is includes an imidazole; wherein the epoxy component and the curing component react together at a temperature of about 100 C to about 130 C to form a substantially cured reaction product in about 10 minutes or less and the cured product shows high tensile and flexural strength. |
| FILED | Friday, June 14, 2019 |
| APPL NO | 17/250186 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/56 (20130101) C08G 59/5073 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/04 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/3445 (20130101) C08K 7/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261930 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Quan Lu (Cambridge, Massachusetts); Qiyu Wang (Cambridge, Massachusetts); Stanley N. Cohen (Palo Alto, California) |
| ABSTRACT | Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168808 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 47/6455 (20170801) Peptides C07K 7/06 (20130101) C07K 14/4718 (20130101) C07K 2319/00 (20130101) C07K 2319/01 (20130101) C07K 2319/03 (20130101) C07K 2319/70 (20130101) C07K 2319/85 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) Original (OR) Class C12N 9/22 (20130101) C12N 9/93 (20130101) C12N 2810/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262074 | Stewart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Colin A. Stewart (Alexandria, Virginia); Richard W. Fonda (Alexandria, District of Columbia); David J. Rowenhorst (Fairfax Station, Virginia); Paul K. Lambert (Columbia, Maryland) |
| ABSTRACT | Disclosed is an alloy having 7-30 wt. % manganese, 1-15 wt. % nickel, 1-10 wt. % aluminum, 1-8 wt. % copper, 0-15 wt. % chromium, 0-5 wt. % molybdenum, 0-3 wt. % vanadium, 0-3 wt. % titanium, 0-3 wt. % niobium, 0-2 wt. % silicon, 0-1 wt. % carbon, and balance of iron. A majority of the iron is γ-Fe. The alloy has β-NiAl precipitates and Cu-rich precipitates. At least 95 vol. % of the β-NiAl precipitates have a maximum dimension of 500 nm or less. The Cu-rich precipitates are at least 40 at. % copper. The alloy can be made by thermal processing steps without mechanical processing steps. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/183879 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 6/02 (20130101) C21D 6/004 (20130101) C21D 6/005 (20130101) C21D 6/008 (20130101) Alloys C22C 38/06 (20130101) C22C 38/34 (20130101) C22C 38/42 (20130101) C22C 38/44 (20130101) C22C 38/46 (20130101) C22C 38/48 (20130101) C22C 38/50 (20130101) C22C 38/58 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262089 | DASGUPTA et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neil P. DASGUPTA (Ann Arbor, Michigan); Jing WANG (Ann Arbor, Michigan); Anish TUTEJA (Ann Arbor, Michigan) |
| ABSTRACT | A rational design and fabrication of ZnO/Al2O3 core-shell nanowire architectures with tunable geometries (length, spacing, branching) and surface chemistry is provided. The fabricated nanowires significantly delay or even prevent marine biofouling. In some embodiments, hydrophilic nanowires can reduce the fouling coverage by up to approximately 60% after 20 days compared to planar control surfaces. The mechanism of the fouling reduction is mainly due to two geometric effects: reduced effective settlement area and mechanical cell penetration. Further, superhydrophobic nanowires can completely prevent marine algal fouling for up to 22 days. Additionally, the developed nanowire surfaces are transparent across the visible spectrum, making them applicable to windows and oceanographic sensors. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/182791 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 59/04 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 35/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/56 (20130101) C23C 16/405 (20130101) C23C 16/407 (20130101) C23C 16/45534 (20130101) Original (OR) Class C23C 16/45553 (20130101) C23C 28/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262118 | Asenath-Smith et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emily Asenath-Smith (Norwich, Vermont); Garrett R. Hoch (Lebanon, New Hampshire); Christopher J. Donnelly (Piermont, New Hampshire); Jordan M. Hodge (Bradford, Vermont) |
| ABSTRACT | In one embodiment employing a vertical draw apparatus, a method of crystallization growth on a substrate surface of a substrate having a substrate material includes: mounting the substrate to a sample holder with the substrate surface facing a liquid surface of a reservoir disposed in a chamber that provides an ambient temperature; seeding the substrate surface with seed droplets; lowering the substrate surface to the liquid surface of the reservoir; independently controlling a temperature of the substrate and a temperature of the reservoir to produce a temperature difference between the substrate and the reservoir over a period of time for crystallization growth; and retracting the substrate surface from the liquid surface of the reservoir at a draw rate. The draw rate and the temperature difference are selected to grow polycrystalline laminate on the substrate surface. Consistent polycrystalline columnar microstructures are formed with appropriate seeding of the substrate surface. |
| FILED | Wednesday, February 26, 2020 |
| APPL NO | 16/802490 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 28/10 (20130101) Original (OR) Class C30B 29/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262399 | Thorup |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessie Thorup (Malden, Massachusetts) |
| ABSTRACT | A distributed control system for a turbomachine and method of operating the distributed control system are provided. In one aspect, a distributed control system includes a central controller and a distributed controller communicatively coupled thereto. The distributed controller has one or more associated local actuators and one or more associated local sensors. The actuators and the sensors are communicatively coupled with the distributed controller. If a communication link between the central controller and the distributed controller becomes faulty, the distributed controller enters an autonomous safety mode. In this mode, the distributed controller uses a combination of its own associated local sensors and past commands received from the central controller to autonomously govern its associated local actuators to maintain safe operation of the turbomachine. |
| FILED | Monday, February 24, 2020 |
| APPL NO | 16/798961 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/10 (20130101) B64D 31/06 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 9/18 (20130101) Original (OR) Class F02C 9/20 (20130101) F02C 9/26 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2270/44 (20130101) F05D 2270/304 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262783 | Kang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wonmo Kang (Tempe, Arizona); Christopher Rudolf (Washington, District of Columbia) |
| ABSTRACT | A system for mechanical testing a specimen includes a 3D printed mechanical testing fixture; a linear actuator having an axis of movement; a controller configured to control the linear actuator; two cameras; a data-acquisition system configured to acquire data from the linear actuator, the controller, and the two cameras; and the specimen. The specimen is marked in two locations with tracking markers to provide indication to the data acquisition system via at least one camera of movement and change in length of the specimen. The fixture includes force-sensing beams extending perpendicular to the axis of force |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/183972 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/16 (20130101) Original (OR) Class Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262857 | STERCZEWSKI et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Lukasz STERCZEWSKI (Plainsboro, New Jersey); Jonas WESTBERG (Princeton, New Jersey); Gerard WYSOCKI (Princeton, New Jersey) |
| ABSTRACT | Disclosed herein is an all-digital phase and timing correction procedure for coherent averaging in dual-comb and multiheterodyne spectroscopy—applicable to any dual-comb spectroscopy setup. It can account for large frequency/phase instabilities of the used sources, yielding a significant reduction of the noise pedestal and an increase in signal-to-noise ratio (SNR) of the radio frequency (RF) beat notes. This technique is computationally efficient and can be conveniently implemented either as a post-processing algorithm or in a real-time data acquisition and processing platform without the necessity of adding any additional optical elements to the dual-comb spectroscopy system. By implementing this technique, the performance of any comb- or comb-like-source-based DCS system with a sufficient degree of mutual coherence between the optical modes can be improved in terms of SNR and number of spectroscopically-usable RF beat notes. The described technique is compatible with a DC-centered RF spectrum, where the negative frequencies are folded to the positive domain to double the number of beat notes within the detector bandwidth. The technique enables coherent averaging over extended time-scales even for free-running combs, thus increasing the sensitivity of absorption and dispersion DCS measurements. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240172 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) Original (OR) Class G01J 3/427 (20130101) G01J 2003/104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262909 | Rudolf |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Rudolf (Washington, District of Columbia) |
| ABSTRACT | A method of measuring millisecond-scale blast and impact characterization in soft materials includes embedding one or more sensors in soft material, wherein the one or more sensors have mechanical properties approximately matching the soft material; applying a constant current to the one or more sensors; subjecting the soft material to a shock or impact event; measuring a response as a change in voltage; and converting the measured voltage to strain or pressure. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184030 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/30 (20130101) Original (OR) Class G01N 3/066 (20130101) G01N 2203/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262925 | MAJOR et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy. (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KEVIN MAJOR (Alexandria, Virginia); KENNETH J. EWING (Edgewood, Maryland); JASBINDER S. SANGHERA (Ashburn, Virginia) |
| ABSTRACT | The apparatus includes a standard computer processor in operation receiving a plurality of stimulus-value signals. The apparatus includes a standard computer-readable medium storing instructions that, when executed by the processor, cause the processor to carry out a method for identifying at least one chemical of interest. The method includes the following. A chromaticity chart including a plurality of chemical groupings is generated. The at least one chemical of interest is classified as belonging to a respective chemical grouping of the plurality of chemical groupings based on the chromaticity chart and the plurality of stimulus-value signals. Optionally, the chromaticity chart includes a molecular vibrational chart. Optionally, the molecular vibrational chart includes a plurality of infrared molecular vibrational signatures of a plurality of target chemicals, a plurality of Raman molecular vibrational signatures of the plurality of target chemicals, or a plurality of terahertz molecular vibrational signatures of the plurality of target chemicals. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245032 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/51 (20130101) G01J 3/52 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/35 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262969 | GALAGAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | James GALAGAN (Needham, Massachusetts); Uros KUZMANOVIC (Brookline, Massachusetts); Luis ORTIZ (Brookline, Massachusetts); Douglas DENSMORE (Malden, Massachusetts); Nicolas Shijie SHU (Levittown, New York) |
| ABSTRACT | Described herein are systems, assays, methods and compositions for identification of oxidase microbial redox-enzymes (MREs) specific to an analyte of interest from an environmental source. The technology relates to identification of analyte-responsive MREs that can quantify the concentration of a target analyte with high specificity and high sensitivity, for example, where the identified analyte-responsive redox-enzyme can be used to engineer an electrochemical biosensor. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/169171 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) C12Q 1/32 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3272 (20130101) Original (OR) Class G01N 27/3274 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262970 | Mirica et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
| INVENTOR(S) | Katherine A. Mirica (Hanover, New Hampshire); Lukasz K. Mendecki (White River Junction, Vermont); Michael Ko (West Lebanon, New Hampshire); Zheng Meng (West Lebanon, New Hampshire); Robert M. Stolz (Lyme, New Hampshire); Aileen Eagleton (Hanover, New Hampshire) |
| ABSTRACT | In some embodiments, the present disclosure pertains to methods of detecting an analyte in a sample by associating the sample with an electrode that includes a metal-organic framework. After association, the redox properties of the electrode are evaluated. Thereafter, the presence or absence of the analyte in the sample is detected by correlating the redox properties of the electrode to the presence or absence of the analyte. In some embodiments, the present disclosure pertains to electrodes that include a metal-organic framework and an electrode surface. In particular embodiments of the present disclosure, the metal-organic framework is associated with the electrode surface. Additional embodiments of the present disclosure pertain to methods of making the electrodes of the present disclosure by associating a metal-organic framework with an electrode surface. In some embodiments, the methods of the present disclosure also include a step of mixing the metal-organic framework with a polymer. |
| FILED | Friday, June 21, 2019 |
| APPL NO | 17/252003 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) C07F 15/04 (20130101) C07F 15/006 (20130101) C07F 15/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3277 (20130101) G01N 27/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263069 | BRUECK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven R.J. BRUECK (Albuquerque, New Mexico); Daniel FEEZELL (Albuquerque, New Mexico); John RANDALL (Albuquerque, New Mexico); Tito BUSANI (Albuquerque, New Mexico); Joshua B. BALLARD (Albuquerque, New Mexico); Mahmoud BEHZADIRAD (Albuquerque, New Mexico); Ashwin Krishnan RISHINARAMANGALAM (Albuquerque, New Mexico) |
| ABSTRACT | Provided is a composite metal-wide-bandgap semiconductor tip for scanning tunneling microscopy and/or scanning tunneling lithography, a method of forming, and a method for using the composite metal-wide-bandgap semiconductor tip. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237697 |
| CURRENT CPC | Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof B82B 3/0004 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/16 (20130101) Original (OR) Class G01Q 70/06 (20130101) G01Q 70/10 (20130101) G01Q 70/12 (20130101) G01Q 70/14 (20130101) G01Q 80/00 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263073 | Stuart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susanne L. Stuart (Petersham, Massachusetts); John C. Grise (Dracut, Massachusetts) |
| ABSTRACT | A radio frequency (RF) test probe adapter comprises a cable adapter operable for use with a RF test probe and a housing. The cable adapter comprises a cable connector configured to physically couple to a connector of a coaxial cable, a first pin operable to electrically couple a center conductor of the coaxial cable to a first lead of the RF test probe, and a second pin operable to electrically couple an outer conductor of the coaxial cable to a second lead of the test probe. The housing is sized and shaped to secure the RF test probe and the cable adapter in a physically coupled configuration |
| FILED | Wednesday, February 26, 2020 |
| APPL NO | 16/802405 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 1/06772 (20130101) Original (OR) Class G01R 13/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263091 | Boglione |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luciano Boglione (Washington, District of Columbia) |
| ABSTRACT | A method to determine noise parameters of a scalable device, is presented in which the determination of the noise parameters of the scalable device is independent of the model adopted for the device. The scalable device is connected as part of a test circuit including a noise source, a recirculator, a first power detector and a second power detector. The first power detector is connected to the recirculator and between the noise source and the scalable device and the second detector is connected to the device under test. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/179143 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 29/26 (20130101) Original (OR) Class G01R 31/2616 (20130101) G01R 31/2626 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263117 | Braje et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Danielle A. Braje (Winchester, Massachusetts); Jennifer Schloss (Cambridge, Massachusetts); Linh M. Pham (Arlington, Massachusetts); John F. Barry (Arlington, Massachusetts); Erik R. Eisenach (Cambridge, Massachusetts); Michael F. O'Keeffe (Medford, Massachusetts); Jonah A. Majumder (Cambridge, Massachusetts); Jessica Kedziora (Shirley, Massachusetts); Peter Moulton (Concord, Massachusetts); Matthew Steinecker (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danielle A. Braje (Winchester, Massachusetts); Jennifer Schloss (Cambridge, Massachusetts); Linh M. Pham (Arlington, Massachusetts); John F. Barry (Arlington, Massachusetts); Erik R. Eisenach (Cambridge, Massachusetts); Michael F. O'Keeffe (Medford, Massachusetts); Jonah A. Majumder (Cambridge, Massachusetts); Jessica Kedziora (Shirley, Massachusetts); Peter Moulton (Concord, Massachusetts); Matthew Steinecker (Medford, Massachusetts) |
| ABSTRACT | We have developed a high-performance, low-volume, low-weight, and low-power sensor based on a self-sustaining oscillator. The techniques described here may be used for sensing various fields; we demonstrate magnetic sensing. The oscillator is based on a dielectric resonator that contains paramagnetic defects and is connected to a sustaining amplifier in a feedback loop. The resonance frequency of the dielectric resonator shifts in response to changes in the magnetic field, resulting in a shift in the frequency of the self-sustaining oscillator. The value of the magnetic field is thereby encoded in the shift or modulation output of the self-sustaining oscillator. The sensor as demonstrated uses no optics, no input microwaves, and, not including digitization electronics, consumes less than 300 mW of power and exhibits a sensitivity at or below tens of pT/√{square root over (Hz)}. In some implementations, the sensor is less than 1 mL in volume. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/134589 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/24 (20130101) Original (OR) Class Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/18 (20130101) H01P 3/06 (20130101) H01P 5/18 (20130101) H01P 7/10 (20130101) Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits H03B 5/1864 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263132 | Ranney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth I. Ranney (Monrovia, Maryland); Kyle A. Gallagher (Silver Spring, Maryland); Daniel T. Galanos (Silver Spring, Maryland); Abigail S. Hedden (Vienna, Virginia); Roger P. Cutitta (Westminster, Maryland) |
| ABSTRACT | According to embodiments, a radar system includes: at least one radio receiver which is comprised of: an antenna configured to receive RF data including both the direct-path RF signal transmitted from a radio transmitter and a reflected RF signal when the transmitted RF signal is reflected from the target; a memory configured to store the same predetermined RF waveform profile data used by the transmitter to generate and transmit the RF signal; a timing unit to provide timing; a matched filter application configured to generate and apply a matched filter for identifying RF signal signatures in RF data; and one or more processors configured to: (i) analyze the received RF data to identify multiple, repeated, individual RF signals corresponding to the direct-path transmitted RF signal; (ii) split the identified RF signals corresponding to the direct-path transmitted RF signal into a plurality of repeating units each having an interval time; (iii) create a matched filter using the predetermined transmit waveform (stored in memory) and apply the matched filter to each of repeating units to provide (a) a plurality of direct-path transmitted RF signal arrival times; and (b) a plurality of reflected RF signal arrival times; (iv) adjust relative arrival times and phases of the repeating units of the direct-path transmitted RF signal; and (v) generate radar data from the reflected RF signal further using the adjusted times and phases for arrival times of the repeating units of the direct-path transmitted RF signal. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/173680 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/288 (20130101) Original (OR) Class G01S 7/292 (20130101) G01S 13/003 (20130101) G01S 2007/2883 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263190 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Zhaoyi LI (Cambridge, Massachusetts); Yao-Wei HUANG (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | An optical device includes a first zone including a first plurality of nanoscale elements. The first plurality of nanoscale elements has a first optical dispersion profile and a first orientation. The optical device has a second zone including a second plurality of nanoscale elements. The second plurality of nanoscale elements has a second optical dispersion profile and a second orientation. The first orientation and the second orientation are configured according to constructive interference for a plurality of wavelengths and a focal length. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184326 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class G02B 2207/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263194 | Schnee |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent P. Schnee (Alexandria, Virginia) |
| ABSTRACT | A method for manufacturing an anti-reflective coating on a surface of an optical component includes the steps of placing a moth eye structure material in apertures of a stamp; placing the stamp on the surface of the optical component such that the moth eye material is in contact with the surface of the optical component; and removing the stamp after the moth eye structure material adheres to the surface of the optical component to create an anti-reflective coating on the surface of the optical component. |
| FILED | Wednesday, December 09, 2020 |
| APPL NO | 17/115868 |
| CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00865 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2063/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 1/118 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263221 | Puckett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | Matthew Wade Puckett (Phoenix, Arizona); Karl D. Nelson (Plymouth, Minnesota) |
| ABSTRACT | An optical coupler device comprises a substrate having a substantially planar upper surface, and a grating structure on the upper surface of the substrate. In one embodiment, the grating structure comprises a copropagating array of waveguides that are substantially parallel to each other and extend along at least a portion of the upper surface of the substrate. Each of the waveguides has opposing sidewalls, wherein a width of each waveguide is defined by a distance between the opposing sidewalls. The opposing sidewalls each have a periodic structure that produces a sidewall modulation for each of the waveguides. An input port is in optical communication with the grating structure. The input port is configured to direct an input light beam in plane into the grating structure such that the beam propagates along the waveguides. The grating structure is configured to diffract the beam out of plane and into free space. |
| FILED | Tuesday, February 25, 2020 |
| APPL NO | 16/800877 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263361 | Lentz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua K. Lentz (Niceville, Florida) |
| ABSTRACT | A system, apparatus, and method include a first display device having a first set of pixels adapted to output light; a second display device having a second set of pixels adapted to output light; a first transparent plate spaced apart from each of the first display device and the second display device. The first transparent plate includes a first set of photonic crystal structures arranged in a first direction and adapted to deviate a first path of the light transmitted from the first and second set of pixels at a first angle. A second transparent plate is spaced apart from the first transparent plate and includes a second set of photonic crystal structures arranged in a second direction different from the first direction and adapted to deviate a second path of the light transmitted through the first transparent plate at a second angle to create a third path of light. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244015 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/13336 (20130101) Original (OR) Class G02F 2202/32 (20130101) Electric Digital Data Processing G06F 3/1446 (20130101) Displaying; Advertising; Signs; Labels or Name-plates; Seals G09F 9/3026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263389 | Hosseini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Analog Photonics LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | Analog Photonics LLC (Boston, Massachusetts) |
| INVENTOR(S) | Ehsan Hosseini (Boston, Massachusetts); Michael Watts (Hingham, Massachusetts) |
| ABSTRACT | Aspects of the present disclosure describe optical phased array structures and devices in which hyperbolic phase envelopes are employed to create focusing and diverging emissions in one and two dimensions. Tuning the phase fronts moves focal point spot in depth and across the array. Grating emitters are also used to emit light upward (out of plane). Adjusting the period of the gratings along the light propagation direction results in focusing the light emitted from the gratings. Changes in the operating wavelengths employed moves the focal spot along the emitters. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/242135 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/292 (20130101) Original (OR) Class G02F 2201/305 (20130101) G02F 2203/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263390 | BECK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristin BECK (College Park, Maryland); Marko Cetina (College Park, Maryland); Michael Goldman (Washington, District of Columbia) |
| ABSTRACT | Aspects of the present disclosure describe techniques for controlling coherent crosstalk errors that occur in multi-channel acousto-optic modulators (AOMs) by applying cancellation tones to reduce or eliminate the crosstalk errors. For example, a method and systems are described that include applying a first radio frequency (RF) tone to generate a first acoustic wave in a first channel of the multi-channel AOM, wherein a portion of the first acoustic wave interacts with a second channel to cause a crosstalk effect, and applying a second RF tone to generate a second acoustic wave in the second channel, wherein the second acoustic wave reduces or eliminates the crosstalk effect caused by the portion of the first acoustic wave. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150909 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/113 (20130101) G02F 1/332 (20130101) Original (OR) Class Multiplex Communication H04J 14/0213 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263578 | MacLaren |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brice MacLaren (Wellesley, Massachusetts) |
| ABSTRACT | Techniques are disclosed for smart distribution of and control of electrical power on a microgrid, such as a photovoltaic (PV) microgrid having a minimal energy buffer (e.g., minimal battery storage). In one aspect, a power distribution method includes receiving a schedule of demand for power being generated by a power source and determining that there is excess power capacity available to service consumers of the power being generated by the power source, the determination of excess power capacity based on a current power capacity of the power source and a current load being applied to the power source, the current load being based on the schedule of demand for power. The method also includes, responsive to a determination that the available excess capacity exceeds an expected maximum draw at a power outlet, activating the power outlet, wherein the power outlet is determined based on the schedule of demand. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/183865 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Electric Digital Data Processing G06F 1/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263753 | Gunlycke |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lennart D. Gunlycke (Alexandria, Virginia) |
| ABSTRACT | Systems and methods are provided for mapping arbitrary isolated quantum-mechanical systems to quantum processor registers on quantum computers that use available symmetry to maximize compactness. For example, embodiments of the present disclosure exploit existing symmetries in the simulated system to minimize the required number of quantum bits (qubits) in the quantum processor. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184516 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/44505 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264080 | Ramprasad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rampi Ramprasad (Atlanta, Georgia); Anand Chandrasekaran (Atlanta, Georgia) |
| ABSTRACT | A system for a material simulation is disclosed. The system may receive an input structure for the material and identify a reference grid point for the material. The system may determine a scalar, vector, and tensorial component for the material. Further, the system may render the vector component and the tensorial component rotationally invariant. Next, the system may generate a first structure fingerprint for the material based on the scalar, vector component, and tensorial component. The system may map the structure fingerprint to stored atomic configurations and based on corresponding stored atomic configuration(s), may determine an approximate total electronic charge density and a plurality of approximate energy levels for the reference grid point. Based on the plurality of approximate energy levels, the system may determine a predictive local density of states for the reference grid point. The system may also generate and display a visual simulation of the material. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/284596 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/25 (20200101) Original (OR) Class G06F 2111/10 (20200101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 3/063 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 60/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264082 | Tehranipoor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark M. Tehranipoor (Gainesville, Florida); Navid Asadi-Zanjani (Gainesville, Florida); Olivia Pauline Paradis (Gainesville, Florida); Nitin Varshney (Gainesville, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide methods, apparatus, systems, computing devices, computing entities for setting deprocessing parameters used in conducting hardware deprocessing on a hardware. In accordance with one embodiment, a method is provided that includes: receiving sample images using different E-beam voltages, wherein each image is captured from a backside of the hardware using a different E-beam voltage; generating thickness-based contour maps, wherein each map is generated for an image and includes contour lines indicating locations having a same thickness of remaining material; generating estimated E-beam penetration depths, wherein each depth is generated for an image and is based at least in part on the E-beam voltage used to capture the image; generating an estimated thickness measurement of the remaining material based at least in part on the contour maps and the penetration depths; and setting the deprocessing parameters based at least in part on the estimated thickness measurement. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167381 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) G06F 30/323 (20200101) Original (OR) Class G06F 30/327 (20200101) G06F 30/331 (20200101) Image Data Processing or Generation, in General G06T 7/50 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264152 | Smalt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Smalt (Arlington, Massachusetts); Gregory Ciccarelli (Cambridge, Massachusetts); William Murphy (Cincinnati, Ohio) |
| ABSTRACT | In some embodiments, a method for enforcing hearing protection safety compliance can include: obtaining one or more images of an ear of a user; preprocessing the one or more images to localize the user's ear and/or a hearing protection device (HPD) worn thereabout; providing the one or more preprocessed images to a classification network; receiving an estimated attenuation value as output of the classification network, the estimated attenuation value corresponding to an estimate of the noise attenuation provided by the HPD work about the user's ear; and automatically enforcing compliance with a safety standard using the estimated noise attenuation value. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 16/797554 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00281 (20130101) G06K 9/00671 (20130101) Original (OR) Class G06K 9/6267 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) Image Data Processing or Generation, in General G06T 3/0006 (20130101) G06T 3/60 (20130101) G06T 7/11 (20170101) G06T 7/70 (20170101) G06T 2207/20132 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/02 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210265240 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute Of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Paul Smith (Chelmsford, Massachusetts); Bernard A. Malouin, JR. (Westford, Massachusetts); Eric A. Browne (Westford, Massachusetts) |
| ABSTRACT | The present invention generally relates to a modular microjet cooler. The modular microjet cooler may be attached to a packaged heat generating device that is mounted on a printed circuit board. The modular microjet cooler has an inlet allowing supply fluid to be directed through microjet nozzles toward an impingement surface on the packaged device. The modular microjet cooler also has one or more outlets that allow exhaust fluid to be removed. The modular microjet cooler is attached to the device after it has been packaged. Further, the modular microjet cooler may be attached to the packaged device either before or after it is mounted to the printed circuit board. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240162 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/13 (20130101) H01L 23/4735 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210265658 | Raj et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rishi Raj (Boulder, Colorado); Viviana Avila (Louisville, Colorado) |
| ABSTRACT | Methods of forming sintered compounds and compounds formed using the methods are disclosed. Exemplary methods include reactive flash sintering to form sintered compounds from two or more starting compounds. Various sintered compounds may be suitable for use as solid electrolytes in solid-state electrochemical cells and batteries. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306828 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/30 (20130101) C01P 2002/54 (20130101) C01P 2002/72 (20130101) C01P 2002/85 (20130101) C01P 2004/02 (20130101) C01P 2006/32 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210265915 | Zaliasl et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ferric Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samira Zaliasl (Jersey City, New Jersey); Noah Sturcken (New York, New York); Denis Shishkov (Brooklyn, New York); Michael Lekas (Brooklyn, New York) |
| ABSTRACT | A power converter includes a primary circuit and a secondary circuit. The primary circuit includes two primary LC circuits that are in parallel electrically with each other. A first node of each primary LC circuit is electrically coupled to a high-voltage input. A second node of each primary LC circuit is coupled to a respective terminal of a primary inductor that forms a transformer with a secondary inductor in the secondary circuit. Each primary LC circuit is electrically coupled to a primary switch that operates at approximately the resonance frequency of the primary LC circuits to output an alternating current that passes through the primary inductor. The terminals of the secondary inductor are coupled to respective secondary switches. The switches operate at the resonance frequency of the primary LC circuit to rectify the power. A low-pass filter outputs the mean of the received voltage. |
| FILED | Tuesday, February 25, 2020 |
| APPL NO | 16/800276 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/083 (20130101) H02M 3/33569 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210259255 | Kucharzyk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katarzyna H. Kucharzyk (Columbus, Ohio); Jeff Cafmeyer (Columbus, Ohio); Veronica Fulwider (Columbus, Ohio); Anthony D. Duong (Columbus, Ohio) |
| ABSTRACT | The invention provides an encapsulated microorganism comprising particles comprising a core and a coating over the core. The core comprises a microorganism and an alginate or polyaspartate. The coating comprises a lipid-based coating. The application of lipid waxes serves to repel diffusion of any water-soluble chemicals that may be present on the surface of commercially available seeds. The lipid waxes applied on top of encapsulated microbial capsules are degradable by enzymes produces by germinating seeds. Thus, the colonization of rhizosphere of germinating plant by the commensal bacteria is a time targeted process to the benefit of the plant. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/183157 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/10 (20130101) A01N 25/26 (20130101) A01N 63/27 (20200101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/38 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260534 | Newbloom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Membrion, Inc. (Seattle, Washington) |
| ASSIGNEE(S) | Membrion, Inc. (Seattle, Washington) |
| INVENTOR(S) | Gregory Matthew Newbloom (Seattle, Washington); Olivia Marie Lenz (Seattle, Washington); Phillip Reaves Pickett (Bainbridge Island, Washington); Rachel Alexis Malone (Seattle, Washington); Stephanie Lynn Candelaria (Seattle, Washington); Yiheng Zhang (Seattle, Washington); Kathryn Lynn Corp (Seattle, Washington); Aditya Ashok Salunkhe (Seattle, Washington); Matthew Jason Canin (Kirkland, Washington) |
| ABSTRACT | Cation exchange membranes and materials including silica-based ceramics, and associated methods, are provided. In some aspects, cation exchange membranes that include a silica-based ceramic that forms a coating on and/or within a porous support membrane are described. The cation exchange membranes and materials may have certain structural or chemical attributes (e.g., pore size/distribution, chemical functionalization) that, alone or in combination, can result in advantageous performance characteristics in any of a variety of applications for which selective transport of positively charged ions through membranes/materials is desired. In some embodiments, the silica-based ceramic contains relatively small pores (e.g., substantially spherical nanopores) that may contribute to some such advantageous properties. In some embodiments, the cation exchange membrane or material includes sulfonate and/or sulfonic acid groups covalently bound to the silica-based ceramic. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244170 |
| CURRENT CPC | Separation B01D 67/0093 (20130101) B01D 69/10 (20130101) B01D 69/148 (20130101) Original (OR) Class B01D 71/027 (20130101) B01D 71/66 (20130101) B01D 71/70 (20130101) B01D 71/78 (20130101) B01D 71/82 (20130101) B01D 2313/40 (20130101) B01D 2323/36 (20130101) B01D 2325/02 (20130101) B01D 2325/12 (20130101) B01D 2325/14 (20130101) B01D 2325/42 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 9/23 (20210101) C25B 13/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260820 | Selter |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC. (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | Thomas Matthew Selter (Blue Springs, Missouri) |
| ABSTRACT | A system and method of additively manufacturing a part including fluorine-containing polymers and an additive. The additive may include stainless steel, bronze, molybdenum disulfide, polyimide, or any other suitable additive. The method includes depositing fluorine-containing polymer additive manufacturing material onto a build platform, selectively cross-linking portions of the deposited additive manufacturing material, and curing the selectively cross-linked portions such that at least one characteristic of the part is improved via the additive. |
| FILED | Monday, February 24, 2020 |
| APPL NO | 16/798561 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260822 | ELTON |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric ELTON (Livermore, California) |
| ABSTRACT | The present disclosure involves a powder particle deposition system for use with an additive manufacturing system, for moving powder particles without physical contact, to recreate a powder bed. The system uses a powder particle container forming a first electrode. A second electrode is spaced apart from the powder particle container and arranged non-parallel to the powder particle container. A signal source applies an electrical signal across the first and second electrodes to create an electric field between the electrodes which varies in strength, such that the electric field is stronger at one side of the powder particle container. This causes the powder particles to move out from the powder container, toward the second electrode, and then to be repelled by the second electrode and to fall onto the powder bed. |
| FILED | Thursday, February 20, 2020 |
| APPL NO | 16/796461 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 5/081 (20130101) B05B 5/087 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/205 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261480 | Weissman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRECISION COMBUSTION, INC. (North Haven, Connecticut) |
| ASSIGNEE(S) | PRECISION COMBUSTION, INC. (North Haven, Connecticut) |
| INVENTOR(S) | Jeffrey Weissman (Guilford, Connecticut) |
| ABSTRACT | A process and apparatus for converting an alkane to an olefin. In one embodiment, the process involves oxidative coupling of an alkane, e.g., methane, with an oxidant, such as air, to produce an olefin having twice the number of carbon atoms as the alkane, e.g., ethylene. In another embodiment, the process involves oxidative dehydrogenation of an alkane, e.g., ethane, with an oxidant to form an olefin having the same number of carbon atoms as the alkane, e.g., ethylene. The process involves passing a flow of the oxidant from a first flow passage through a porous medium; diffusing a flow of the alkane from a second flow passage into the porous medium; and contacting the reactant alkane and the oxidant in the presence of a catalyst within the porous medium to produce the olefin. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318689 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 12/007 (20130101) B01J 19/249 (20130101) B01J 19/2415 (20130101) B01J 2219/247 (20130101) B01J 2219/2409 (20130101) Acyclic or Carbocyclic Compounds C07C 2/84 (20130101) Original (OR) Class C07C 5/333 (20130101) C07C 11/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261511 | Mukhopadhyay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aindrila Mukhopadhyay (Oakland, California); Thomas T. Eng (Berkeley, California) |
| ABSTRACT | The present invention provides for a genetically modified bacterial host cell comprising one or more enzymes of a heterologous isoprenoid or isopentenol production pathway and capable of producing tetramethyl pyrazine. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185196 |
| CURRENT CPC | Heterocyclic Compounds C07D 241/04 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/52 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261632 | Shanklin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brookhaven Science Associates, LLC (Upton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Shanklin (Shoreham, New York); Sanket P. Anaokar (Carle Place, New York) |
| ABSTRACT | The invention provides mutant or variant oleosin polypeptides having one or more amino acid substitutions, particularly one or more arginine substitution for lysine, and having one or more amino acid deletions. The mutant oleosin polypeptides provide for higher triacylglycerol compared to wild type oleosin, including when the mutant oleosin is expressed in plants. Also provided are polynucleotides encoding the mutant oleosin(s), constructs and host cells comprising the polynucleotides, methods for producing oil bodies comprising the mutant oleosin(s) and for producing oil in host cells and plants. The invention also relates to plants, particularly transgenic or recombinantly engineered plants, expressing one or more of the mutant oleosin polypeptides, as well as seeds and oil bodies derived from the plants. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180195 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261749 | THORNBURG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Earl THORNBURG (Denver, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes a lignin-derived mixture that includes at least one of a dimer, a trimer, and/or a tetramer, where the composition is characterized by a thermal stability up to a maximum temperature between about 260° C. and about 300° C. |
| FILED | Tuesday, September 01, 2020 |
| APPL NO | 17/008864 |
| CURRENT CPC | Separation B01D 3/14 (20130101) B01D 3/4227 (20130101) B01D 5/006 (20130101) B01D 5/009 (20130101) B01D 11/0488 (20130101) B01D 11/0492 (20130101) Compounds of Unknown Constitution C07G 1/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/22 (20130101) Original (OR) Class C08J 2397/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261911 | BECKHAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); UT-Battelle, LLC (Oak Ridge, Tennessee); Technical University of Denmark (Danmarks Tekniske Universitet) (Lyngby, Denmark) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregg Tyler BECKHAM (Golden, Colorado); Christopher W. JOHNSON (Denver, Colorado); Allison Jean ZIMONT WERNER (Denver, Colorado); Davinia SALVACHÚA RODRÍGUEZ (Golden, Colorado); Daniel A. JACOBSON (Oak Ridge, Tennessee); Erika TEIXEIRA PRATES (Oak Ridge, Tennessee); Elsayed Tharwat Tolba MOHAMED (Helsingborg, Sweden); Adam Michael FEIST (San Diego, California) |
| ABSTRACT | Disclosed herein are the genetically modified Pseudomonas with improved tolerance to hydroxycinnamic acids. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184580 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) Original (OR) Class C12N 15/78 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/38 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261943 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl Hirschie Johnson (Nashville, Tennessee); Philip D. Weyman (Cardiff, California); Qing Xu (North Potomac, Maryland); Yao Xu (Nashville, Tennessee) |
| ABSTRACT | A method of increasing gene expression by manipulating the circadian clock is described that includes transforming a photosynthetic organism to include an expression control sequence that modulates the expression of a clock gene to increase expression of a target gene. Photosynthetic organism having a modified circadian cycle reflecting this method are also described. |
| FILED | Sunday, February 21, 2021 |
| APPL NO | 17/180816 |
| CURRENT CPC | Peptides C07K 14/62 (20130101) C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0067 (20130101) C12N 15/00 (20130101) Original (OR) Class C12N 15/74 (20130101) C12N 15/8222 (20130101) Enzymes C12Y 112/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261993 | Noguera et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| INVENTOR(S) | Daniel R. Noguera (Madison, Wisconsin); Timothy James Donohue (Middleton, Wisconsin); Jose Perez (Madison, Wisconsin); Wayne S. Kontur (Madison, Wisconsin); German Eduardo Umana Chapeton (Madison, Wisconsin) |
| ABSTRACT | Recombinant microorganisms configured for enhanced production of compounds such as 2-pyrone-4,6-dicarboxylic acid (PDC) and methods of using the recombinant microorganisms for the production of these compounds. The recombinant microorganisms include one or more modifications that reduce 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) cis-trans isomerase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) methyl esterase activity, and/or vanillate/3-O-methylgallate O-demethylase activity. The recombinant microorganisms can be used to generate PDC from media comprising plant-derived phenolics, such as syringyl phenolics, guaiacyl phenolics, and p-hydroxyphenyl phenolics. The plant-derived phenolics can be derived from pretreated lignin, including depolymerized lignin or other chemically altered lignin. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313675 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/18 (20130101) C12N 9/90 (20130101) C12N 9/1007 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/06 (20130101) Original (OR) Class Enzymes C12Y 301/01057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262088 | Otto |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Laminera LLC (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lauren M. Otto (Berkeley, California) |
| ABSTRACT | This invention relates to substrate processing and describes a method for depositing a film on a substrate in a substrate processing chamber, the substrate comprising a surface comprising a surface species, the method comprising: depositing a layer of material on the substrate surface by flowing a precursor into the chamber and over the substrate surface to form a material layer on the substrate surface, the material layer comprising ligands remaining from the precursor; substantially removing excess molecular precursor from the processing chamber; flowing one or more reactive species into the substrate processing chamber and over the surface of the substrate to remove the ligands and combine with the material surface forming a compound with the material, the reactive species comprising one or more mean free path limited species with at least one inert gas species being flowed into the substrate processing chamber simultaneously with the mean free path limited species. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/174150 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/45527 (20130101) Original (OR) Class C23C 16/45553 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262104 | Trembly |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio University (Athens, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Patrick Trembly (Athens, Ohio) |
| ABSTRACT | An apparatus for converting carbon dioxide and natural gas liquids into other chemicals and/or fuels, comprising at least one electrochemical cell, wherein the electrochemical cell reduces the endothermic load associated with electrochemical CO2 reduction, and a method for converting carbon dioxide and natural gas liquids into carbon monoxide and other chemicals and/or fuels, comprising converting CO2 into CO and converting C2H6 into C2H4 at a temperature in the range of 650° C.-750° C. |
| FILED | Wednesday, October 30, 2019 |
| APPL NO | 17/284589 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) Original (OR) Class C25B 9/19 (20210101) C25B 9/70 (20210101) C25B 15/021 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262217 | HUN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DIANA HUN (Lenoir City, Tennessee); UDAY K. VAIDYA (Knoxville, Tennessee); STEPHEN W. SHERIFF (Friendsville, Tennessee); Nitilaksha P. Hiremath (Oak Ridge, Tennessee) |
| ABSTRACT | An erection lifting insert for precast insulated panel having an insulating material layer between opposing wythes, the insulating material layer, wythes, and precast insulated panel having respective widths. The erection lifting insert includes an insert body. Opposing elongated engagement arms extend outward from the opposing sides of the insert body and downward past the bottom of the insert body. The opposing engagement arms are provided on each lateral side of the insert body between the midpoint and the side edges. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/187209 |
| CURRENT CPC | General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 1/043 (20130101) Original (OR) Class E04B 1/4185 (20130101) E04B 1/7608 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262227 | HUN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DIANA HUN (Lenoir City, Tennessee); UDAY K. VAIDYA (Knoxville, Tennessee); STEPHEN W. SHERIFF (Friendsville, Tennessee); DYLAN M. TALLEY (Oak Ridge, Tennessee); NOLAN W. HAYES (Jefferson City, Tennessee); ZHONGGUO JOHN MA (Knoxville, Tennessee) |
| ABSTRACT | A stripping lifting insert is provided for precast insulated panels having an insulating material layer between opposing wythes, the insulating material layer, wythes, and precast insulated panel having respective widths. The stripping lifting insert includes an elongated connecting shaft having a shaft axis. First and second spaced apart wythe engagement members are connected to the connecting shaft in spaced apart relation to each other. Each wythe engagement member includes a hub and a plurality of three or more protrusions connected to and emanating from hub. Each of the protrusions extending radially outward from the shaft axis. The wythe engagement members have a height less than the width of the wythes, whereby each wythe engagement member can be completely embedded in a respective wythe of the precast insulated panel. A precast insulated panel and a method of making a precast insulated panel are also disclosed. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/187044 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 7/0014 (20130101) Structural Elements; Building Materials E04C 2/044 (20130101) E04C 2/288 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262902 | Kertesz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vilmos Kertesz (Oak Ridge, Tennessee); Bernadeta R. Srijanto (Knoxville, Tennessee); Charles P. Collier (Knoxville, Tennessee); John F. Cahill (Knoxville, Tennessee) |
| ABSTRACT | A method and system for sampling a solid sample material can include the step of mounting the sample material on a support. A sample surface is coated with a surface treatment composition in a dry deposition process. A solvent supply conduit for supplying solvent to the sample surface and a solvent exhaust conduit for withdrawing solvent from the sample surface can be provided. Solvent is flowed from the solvent supply conduit to the surface treatment composition and the sample surface such that the solvent contacts the surface treatment composition. A laser beam is directed from a laser source to the sample and the surface treatment composition. The laser beam will ablate the sample and the surface treatment composition in portions intersected by the laser beam. Ablated sample material enters the solvent liquid and will be transported with the solvent away from the sample surface through the solvent exhaust conduit. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 16/797712 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/04 (20130101) Original (OR) Class G01N 1/38 (20130101) G01N 2001/045 (20130101) G01N 2001/383 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/164 (20130101) H01J 49/0463 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263002 | BOGGESS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ANDREW J. BOGGESS (AIKEN, South Carolina); STEPHEN L. CRUMP (MARTINEZ, Georgia); THOMAS L. WHITE (EVANS, Georgia) |
| ABSTRACT | Sampling devices for sampling an aqueous source (e.g., field testing of ground water) for multiple different analytes are described. Devices include a solid phase extraction component for retention of a wide variety of targeted analytes. Devices include analyte derivatization capability for improved extraction of targeted analytes. Thus, a single device can be utilized to examine a sample source for a wide variety of analytes. Devices also include an isotope dilution capability that can prevent error introduction to the sample analysis and can correct for sample loss and degradation from the point of sampling until analysis as well as correction for incomplete or poor derivatization reactions. The devices can be field-deployable and rechargeable. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244167 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/10 (20130101) G01N 1/405 (20130101) G01N 33/1826 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263108 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin Li (Idaho Falls, Idaho); Eric J. Dufek (Ammon, Idaho); Ningshengjie Gao (Idaho Falls, Idaho) |
| ABSTRACT | Methods for diagnosing failure mechanisms and for predicting lifetime of metal batteries include monitoring rest voltage and Coulombic Efficiency over relatively few cycles to provide profiles that indicate, by the trends thereof, a particular failure mechanism (e.g., electrolyte depletion, loss of metal inventory, increased cell impedance). The methods also include cycling over relatively few cycles an anode-free cell, having the same cathode and electrolyte as the metal battery, but with a current collector instead of the anode. Discharge capacity is monitored and profiled, and a discharge capacity curve is fitted to the discharge capacity profile to discern a capacity retention per cycle. The lifetime of the metal battery is determined using the capacity retention per cycle discerned from the anode-free cell. Related systems include a metal-based battery and an anode-free cell or a battery cell reconfigurable between a metal-based and an anode-free cell. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/249158 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/392 (20190101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263201 | Nguyen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hoang T. Nguyen (Livermore, California) |
| ABSTRACT | Optical structures, including thin film designs and components with topography, are provided that achieve significantly improved laser damage thresholds and/or ultra-low-loss. These advances may be achieved by utilizing a bulk window comprising a material having a band gap that is at least 5.0 eV and a thickness. The bulk window can be configured to increase the laser induced damage threshold of the underlying optical structure. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172979 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/1833 (20130101) G02B 5/1847 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263357 | de Pablo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan Jose de Pablo (Chicago, Illinois); Paul Franklin Nealey (Chicago, Illinois); Xiao Li (Chicago, Illinois); Jose A. Martinez-Gonzalez (Chicago, Illinois); Monirosadat Sadati (Chicago, Illinois); Rui Zhang (Chicago, Illinois); Ye Zhou (Chicago, Illinois) |
| ABSTRACT | Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/249646 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/00 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/137 (20130101) G02F 1/1393 (20130101) Original (OR) Class G02F 1/1396 (20130101) G02F 2201/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263740 | KALAMATIANOS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ADVANCED MICRO DEVICES, INC. (SANTA CLARA, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JOHN KALAMATIANOS (BOXBOROUGH, Massachusetts); KRISHNAN V. RAMANI (SANTA CLARA, California); SUSUMU MASHIMO (FUKUOKA, Japan) |
| ABSTRACT | Address-based filtering for load/store speculation includes maintaining a filtering table including table entries associated with ranges of addresses; in response to receiving an ordering check triggering transaction, querying the filtering table using a target address of the ordering check triggering transaction to determine if an instruction dependent upon the ordering check triggering transaction has previously been generated a physical address; and in response to determining that the filtering table lacks an indication that the instruction dependent upon the ordering check triggering transaction has previously been generated a physical address, bypassing a lookup operation in an ordering violation memory structure to determine whether the instruction dependent upon the ordering check triggering transaction is currently in-flight. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238844 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/35 (20130101) G06F 9/3842 (20130101) G06F 9/30043 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263885 | PANAS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Matthew PANAS (Dublin, California) |
| ABSTRACT | The present disclosure relates to an electronic control system for controlling controllable elements of an external component. The system makes use of a state translator subsystem (“STS”) for receiving a state command from an external subsystem. The STS may have at least one module for processing the state command and generating operational commands over a first plurality of channels in parallel form, for controlling the elements of the external component. A programmable calibration command translation layer subsystem (“PCCTL”) is used and configured to receive and use the operational commands to generate granular level commands for controlling the elements, and to transmit the granular level commands over a second plurality of channels in parallel form. A subsystem is coupled between the PCCTL and the elements, and configured to receive the granular level commands from the PCCTL and to use the granular level commands to generate final output commands. The final output commands are applied in parallel, over a third plurality of channels, to the elements. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244332 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 26/0833 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/021 (20130101) Electric Digital Data Processing G06F 13/37 (20130101) G06F 13/126 (20130101) G06F 15/825 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264309 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IONQ, INC. (College Park, Maryland); University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingfeng Wang (College Park, Maryland); Ming Li (College Park, Maryland); Yunseong Nam (College Park, Maryland) |
| ABSTRACT | Aspects of the present disclosure describe a method including predicting a first set of ansatz terms and a first plurality of amplitudes associated with the first set of ansatz terms; minimizing energy of the system based on the first set of ansatz terms and the first plurality of amplitudes; computing perturbative corrections using one or more ansatz wavefunctions; determining whether energy of the system converges; and predicting, in response to determining that the energy of the system does not converge, a second set of ansatz terms and a second plurality of amplitudes associated with the second set of ansatz terms. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/177813 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5094 (20130101) G06F 30/20 (20200101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264663 | Gang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Oleg Gang (Setauket, New York); Ye Tian (Nanjing, China PRC); Jason S. Kahn (New York, New York); Yan Xiong (New York, New York); Brian Minevich (New York, New York); Sanat K. Kumar (New York, New York) |
| ABSTRACT | The present subject matter relates to a voxel and methods of organizing an object into a three-dimensional (3D) array using the voxel. The voxel can include a plurality of frames including at least one single stranded (ss) DNA motif with at least one free base, wherein the at least one ssDNA motif hybridizes with a complementary strand fragment of other frames. |
| FILED | Wednesday, October 14, 2020 |
| APPL NO | 17/070643 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 17/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210265111 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian-Ping WANG (Shoreview, Minnesota); YanFeng JIANG (Berkeley, California) |
| ABSTRACT | Techniques are disclosed concerning applied magnetic field synthesis and processing of iron nitride magnetic materials. Some methods concern casting a material including iron in the presence of an applied magnetic field to form a workpiece including at least one iron-based phase domain including uniaxial magnetic anisotropy, wherein the applied magnetic field has a strength of at least about 0.01 Tesla (T). Also disclosed are workpieces made by such methods, apparatus for making such workpieces and bulk materials made by such methods. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245641 |
| CURRENT CPC | Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 27/02 (20130101) Alloys C22C 38/001 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/06 (20130101) H01F 1/08 (20130101) H01F 1/047 (20130101) H01F 41/0266 (20130101) H01F 41/0273 (20130101) Original (OR) Class Dynamo-electric Machines H02K 1/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210265128 | Winston |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander J. Winston (Idaho Falls, Idaho) |
| ABSTRACT | A specimen mount may include a pin stub and a base member. The pin stub may be sized and configured for mounting in an inspection device. The base member may be sized and configured for mounting in a polishing machine. The base member may include a coupler sized and configured to receive the pin stub and couple the pin stub to the base member. A method of preparing a specimen may comprise positioning the specimen on a pin stub and coupling the pin stub to the base member. The base member with the pin stub and specimen may then be positioned in a polishing machine. A method of manufacturing a specimen mount may comprise forming a base member sized and configured for mounting in a polishing machine, and forming a coupler in the base member sized and configured to receive a pin stub. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 16/947072 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/20 (20130101) Original (OR) Class H01J 37/28 (20130101) H01J 2237/2007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210265549 | REN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Zhifeng REN (Pearland, Texas); Hangtian ZHU (Houston, Texas) |
| ABSTRACT | A ZrCoBi-based p-type half-Heusler material can have a formula: ZrCoBi1-x-ySnxSby, where x can vary between 0.01 and 0.25, and y can vary between 0 and 0.2. An average dimensionless figure-of-merit (ZT) for the material can be greater than or equal to about 0.80 as calculated by an integration method for temperatures between 300 and 973 K. A ZrCoBi-based n-type half-Heusler material can have a formula: ZrCo1-xNixBi1-ySby, where x can vary between 0.01 and 0.25, and y can vary between 0 and 0.3. The material has an average dimensionless figure-of-merit (ZT) is greater than or equal to about 0.65 as calculated by an integration method for temperatures between 300 and 973 K. |
| FILED | Wednesday, June 26, 2019 |
| APPL NO | 17/252659 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/02 (20130101) H01L 35/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210265608 | Oakes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Landon J. Oakes (Cambridge, Massachusetts); Haley L. Orler (Bridgeville, Pennsylvania); Elizabeth A. Furar (Pittsburgh, Pennsylvania); Stuart D. Hellring (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present invention is directed to a method of coating an electrical current collector comprising treating a portion of a surface of the electrical current collector with an adhesion promoting composition to deposit a treatment layer over the portion of the surface of the electrical current collector, wherein the resulting surface of the electrical current collector comprises (a) a treated portion comprising the treatment layer and (b) a non-treated portion that lacks the treatment layer; electrodepositing an electrodeposited coating layer from an electrodepositable coating composition onto the surface of the electrical current collector to form a coated electrical current collector; and rinsing the coated electrical current collector, wherein the electrodeposited coating layer substantially adheres to the treated portion of the surface and does not adhere to the non-treated portion of the surface. Also disclosed are electrodes and electrical storage devices. |
| FILED | Wednesday, February 26, 2020 |
| APPL NO | 16/801507 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0404 (20130101) Original (OR) Class H01M 4/623 (20130101) H01M 4/661 (20130101) H01M 4/663 (20130101) H01M 4/669 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210265631 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | 24M Technologies, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junzheng CHEN (Concord, Massachusetts); Landon OAKES (Cambridge, Massachusetts); Naoki OTA (Lexington, Massachusetts) |
| ABSTRACT | Embodiments described herein relate to electrochemical cells with one or more electrodes coupled directly to a film material, and methods of making the same. In some embodiments, an electrochemical cell includes a first electrode material disposed on a first current collector, wherein the first current collector is coupled to a first non-conductive film. In some embodiments, a first tab is coupled to the first current collector. The electrochemical cell further includes a second electrode material capable of taking up or releasing ions during operation of the electrochemical cell. The second electrode material is coupled directly to a second non-conductive film. A second tab is electronically coupled to the second electrode material. A separator is disposed between the first electrode material and the second electrode material. In some embodiments, the second tab can be coupled directly to the second electrode material. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181554 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/62 (20130101) Original (OR) Class H01M 4/0402 (20130101) H01M 50/105 (20210101) H01M 50/536 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210265658 | Raj et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rishi Raj (Boulder, Colorado); Viviana Avila (Louisville, Colorado) |
| ABSTRACT | Methods of forming sintered compounds and compounds formed using the methods are disclosed. Exemplary methods include reactive flash sintering to form sintered compounds from two or more starting compounds. Various sintered compounds may be suitable for use as solid electrolytes in solid-state electrochemical cells and batteries. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306828 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/30 (20130101) C01P 2002/54 (20130101) C01P 2002/72 (20130101) C01P 2002/85 (20130101) C01P 2004/02 (20130101) C01P 2006/32 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210265796 — SPACE-TIME INDUCED LINEARLY ENCODED TRANSCRIPTION FOR TEMPORAL OPTIMIZATION (STILETTO)
| US 20210265796 | Muir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security.LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Ryan D. Muir (Livermore, California); John E. Heebner (San Ramon, California); Daniel E. Mittelberger (Livermore, California) |
| ABSTRACT | Space-to-time pulse shaping techniques are provided that maintain high fidelity with a practical output coupler, maintain an output resolution that is no longer than the input pulse, and are scalable to long records while maintaining fine resolution. |
| FILED | Thursday, February 20, 2020 |
| APPL NO | 16/796564 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) Original (OR) Class H01S 3/0085 (20130101) H01S 3/235 (20130101) H01S 3/0675 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210259585 | GALAGAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | James GALAGAN (Needham, Massachusetts); Mark W. GRINSTAFF (Brookline, Massachusetts); Uros KUZMANOVIC (Brookline, Massachusetts); Mingfu CHEN (Boston, Massachusetts); Margarita Alexandrovna TARARINA (Bryn Mawr, Pennsylvania); Karen Nazaretian ALLEN (Weston, Massachusetts) |
| ABSTRACT | Described herein is an amperometric biosensor, e.g., chronoamperometric biosensor for the measurement of the concentration of nicotine. Also disclosed herein is a wearable nicotine biosensor device and a biosensor that detects nicotine in smoke. The biosensor disclosed herein comprises a nicotine-catalyzing enzyme, such as NicA2 or mutant NicA2 enzymes. Also described herein are systems comprising said amperometric biosensor, e.g., chronoamperometric biosensor and methods of using said chronoamperometric biosensor. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/169193 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1486 (20130101) Original (OR) Class A61B 5/4845 (20130101) A61B 5/14517 (20130101) A61B 10/0064 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/004 (20130101) C12Q 1/005 (20130101) C12Q 1/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3272 (20130101) G01N 33/48714 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210259639 | UVAYDOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel UVAYDOV (Allston, Massachusetts); Raffaele GUIDA (Boston, Massachusetts); Francesco RESTUCCIA (Boston, Massachusetts); Tommaso MELODIA (Newton, Massachusetts) |
| ABSTRACT | A deep learning medical device implantable in a body is provided. The device includes a processing and communication unit and a sensing and actuation unit. The processing and communication unit includes a deep learning module including a neural network trained to process the input samples, received from the sensing and actuation unit, through a plurality of layers to classify physiological parameters and provide classification results. A communication interface in communication with the deep learning module receives the classification results for ultrasonic transmission through biological tissue. Methods of sensing and classifying physiological parameters of a body and methods of embedding deep learning into an implantable medical device are also provided. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176229 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/74 (20130101) A61B 5/6867 (20130101) A61B 5/7225 (20130101) A61B 5/7267 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210259984 | PRUD'HOMME et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Robert K. PRUD'HOMME (Princeton, New Jersey); Chester E. MARKWALTER (Princeton, New Jersey); Robert F. PAGELS (Princeton, New Jersey) |
| ABSTRACT | Hydrophilic molecules such as biologics, which can include peptides, proteins, and other biologically-derived materials, can be used as therapeutic agents in medical applications. They can face administration challenges because of poor membrane permeability and rapid clearance from the blood stream. Methods for the formation of a core-shell-brush nanoparticle from an A-B-C triblock copolymer are set forth. A hydrophilic core can contain the biologic and the C Block of the copolymer. The shell can be comprised of the precipitated B Block, and the A Block can form a stabilizing brush layer. The particles can be assembled by sequential precipitations under defined mixing conditions. Presented herein are methods to tune release based on process parameters during particle assembly and triblock characteristics. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/260640 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) A61K 9/5169 (20130101) A61K 9/5192 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/08 (20130101) C08G 63/664 (20130101) C08G 73/1092 (20130101) C08G 81/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260101 | Rice et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles V. Rice (Norman, Oklahoma); Daniel T. Glatzhofer (Norman, Oklahoma) |
| ABSTRACT | Compositions of β-lactam antibiotics and branched poly(ethylenimine) (BPEI), and β-lactam antibiotics and potentiating compounds of polyethylene glycol (PEG)-BPEI conjugates, and methods of their use to treat infections and to remove bacterial biofilms from surfaces of devices and wounds. The BPEI and PEG-BPEI conjugates potentiate the activity of the β-lactam antibiotics so the compositions have synergistic effects against various Gram-positive bacteria. For example, the compositions can be used to treat Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-resistant Staphylococcus epidermidis (MRSE), that have developed resistance against most β-lactam antibiotics. The BPEI and PEG-BPEI conjugates result in the resensitization of such resistant bacterial strains to traditional antibiotic therapies such as β-lactam antibiotics. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231854 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 33/04 (20130101) A01N 43/44 (20130101) A01N 43/86 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/407 (20130101) A61K 31/427 (20130101) A61K 31/785 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260222 | MORROW et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janet R. MORROW (Williamsville, New York); Zuiru LIN (Williamsville, New York); Didar ASIK (Tonawanda, New York); Eric M. SNYDER (Tonawanda, New York); Elizabeth A. KRAS (Amherst, New York) |
| ABSTRACT | Macrocyclic complexes and macrocyclic compounds. The macrocyclic complexes or macrocyclic compounds have a TACN moiety with one or more amine group(s) or a O- or S-substituted TACN moiety. The macrocyclic complexes have a high-spin Fe(III) atom coordinated to the TACN moiety. The macrocyclic complexes can be used in imaging methods. |
| FILED | Monday, November 18, 2019 |
| APPL NO | 16/973349 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/106 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6515 (20130101) C07F 15/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260578 | Shirwaiker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rohan Shirwaiker (Raleigh, North Carolina); Parth Chansoria (Raleigh, North Carolina); Lokesh Narayanan (Raleigh, North Carolina) |
| ABSTRACT | Method of ultrasound-assisted 3D bioprinting includes depositing a bioink fluid matrix containing a suspension of cells into a chamber comprising two piezo transducers on opposing ends of the chamber. The method further includes vibrating the piezo transducers to generate longitudinal bulk acoustic waves within the bioink fluid matrix such that waves from opposing piezo transducers superimpose to form a standing bulk acoustic wave to drive the cells to cluster and align along one or more nodes or nodal planes formed within the bioink fluid matrix at points of intersection of the standing bulk acoustic wave. The nodes or nodal planes are spaced apart from each other by a distance equaling half a wavelength of the standing bulk acoustic wave. The nodes or nodal planes further mimic a contour of the vibrating surfaces of the piezo transducers. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/207057 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2200/0668 (20130101) B01L 2400/0436 (20130101) B01L 2400/0439 (20130101) Typewriters; Selective Printing Mechanisms,, i.e Mechanisms Printing Otherwise Than From a Forme; Correction of Typographical Errors B41J 2/14008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260820 | Selter |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC. (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | Thomas Matthew Selter (Blue Springs, Missouri) |
| ABSTRACT | A system and method of additively manufacturing a part including fluorine-containing polymers and an additive. The additive may include stainless steel, bronze, molybdenum disulfide, polyimide, or any other suitable additive. The method includes depositing fluorine-containing polymer additive manufacturing material onto a build platform, selectively cross-linking portions of the deposited additive manufacturing material, and curing the selectively cross-linked portions such that at least one characteristic of the part is improved via the additive. |
| FILED | Monday, February 24, 2020 |
| APPL NO | 16/798561 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261411 | Wolden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Colin A. Wolden (Denver, Colorado); William H. Smith (Golden, Colorado) |
| ABSTRACT | Methods of forming Li2S and other MSn nanocrystals are provided. The methods employ low-cost lithium salts as a reagent and utilizes one or more metathesis reactions that occur either in solution, preferably at or near ambient conditions, or in the solid-state at elevated temperatures. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180479 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 17/40 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2004/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261431 | CURRY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tuskegee University (Tuskegee, Alabama) |
| ASSIGNEE(S) | Tuskegee University (Tuskegee, Alabama) |
| INVENTOR(S) | Michael L. CURRY (Tuskegee, Alabama); Aiesha L. ETHRIDGE (Tuskegee, Alabama); Demetrius FINLEY (Tuskegee, Alabama) |
| ABSTRACT | This invention relates to cost-effective methods for synthesizing metallic nanoparticles in high yield using non-dendrimeric branched polymeric templates, such as branched polyethyleneimine. This invention also provides a high-throughput apparatus for synthesizing metallic nanoparticles under conditions that produce less waste than conventional nanoparticle synthesis methods. Also provided are metallic nanoparticles and multi-metallic nanoparticle compositions made by methods and high-throughput apparatus of the invention. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175137 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/24 (20130101) B01J 19/123 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0018 (20130101) B22F 9/24 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 3/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261503 | KATTAMURI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| ASSIGNEE(S) | WILLIAM MARSH RICE UNIVERSITY (Houston, Texas) |
| INVENTOR(S) | Padmanabha Venkatesh KATTAMURI (Houston, Texas); Laszlo KURTI (Houston, Texas) |
| ABSTRACT | In one aspect, the present disclosure provides methods of preparing a secondary amine. In some embodiments, the secondary amine comprises two different groups or two identifical groups. Also provided herein are compositions for use in the preparation of the secondary amine. |
| FILED | Thursday, May 17, 2018 |
| APPL NO | 16/614272 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 69/36 (20130101) C07C 69/675 (20130101) C07C 227/06 (20130101) C07C 229/04 (20130101) C07C 311/19 (20130101) Original (OR) Class C07C 381/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261565 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); The Scripps Research Institute (Jupiter, Florida) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Mingji Dai (West Lafayette, Indiana); Dexter Cameron Davis (West Lafayette, Indiana); Alexander Adibekian (Palm, Florida); Dominic Gregor Hoch (Jupiter, Florida); Zhong-Yin Zhang (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging thugs for cancers. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/246775 |
| CURRENT CPC | Heterocyclic Compounds C07D 493/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261589 | Li |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Li (Tempe, Arizona) |
| ABSTRACT | Porphyrins and porphyrin derivatives of General Formulas I-V are suitable for use as donor-type materials for photovoltaic cells, absorbers for dye-sensitized solar cells, emitters for red and near infra-red organic light-emitting diodes (OLEDs), absorbers and re-emitters for organic concentrators (e.g., large area organic film for collection of sunlight) for small-size and high efficiency inorganic photovoltaics, and absorbers for hydrogeneration. |
| FILED | Tuesday, July 16, 2019 |
| APPL NO | 17/251824 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0093 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261591 | Swarts |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Central Michigan University (Mount Pleasant, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin M. Swarts (Mount Pleasant, Michigan) |
| ABSTRACT | Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the disclosed trehalose analogues may be useful in the detection of bacteria. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306701 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 7/06 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) C12Q 1/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/60 (20130101) G01N 33/582 (20130101) G01N 2333/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261925 | Sherman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David H. Sherman (Ann Arbor, Michigan); Amy E. Fraley (Ann Arbor, Michigan); Ashootosh Tripathi (Ypsilanti, Michigan) |
| ABSTRACT | The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228211 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4995 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0071 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/182 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262089 | DASGUPTA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neil P. DASGUPTA (Ann Arbor, Michigan); Jing WANG (Ann Arbor, Michigan); Anish TUTEJA (Ann Arbor, Michigan) |
| ABSTRACT | A rational design and fabrication of ZnO/Al2O3 core-shell nanowire architectures with tunable geometries (length, spacing, branching) and surface chemistry is provided. The fabricated nanowires significantly delay or even prevent marine biofouling. In some embodiments, hydrophilic nanowires can reduce the fouling coverage by up to approximately 60% after 20 days compared to planar control surfaces. The mechanism of the fouling reduction is mainly due to two geometric effects: reduced effective settlement area and mechanical cell penetration. Further, superhydrophobic nanowires can completely prevent marine algal fouling for up to 22 days. Additionally, the developed nanowire surfaces are transparent across the visible spectrum, making them applicable to windows and oceanographic sensors. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/182791 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 59/04 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 35/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/56 (20130101) C23C 16/405 (20130101) C23C 16/407 (20130101) C23C 16/45534 (20130101) Original (OR) Class C23C 16/45553 (20130101) C23C 28/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262103 | Blakemore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James D. Blakemore (Lawrence, Kansas); Kevin C. Leonard (Lawrence, Kansas); Bala Subramaniam (Lawrence, Kansas) |
| ABSTRACT | Processes for the electrochemical reduction of CO2 are provided. In an embodiment, such a process comprises passing a current through a CO2 expanded liquid medium under a pressure greater than 0.2 MPa and less than 7.4 MPa in the presence of a catalyst to reduce and convert CO2 to one or more products, wherein the CO2 expanded liquid medium comprises dissolved CO2, a liquid solvent, and a dissolved electrolyte, and wherein the liquid solvent and the dissolved electrolyte are selected to provide a concentration of the dissolved CO2 of at least 2 M at the pressure. |
| FILED | Friday, July 05, 2019 |
| APPL NO | 17/255059 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) Original (OR) Class C25B 3/26 (20210101) C25B 9/17 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262854 | BRUECK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven R.J. BRUECK (Albuquerque, New Mexico); Alexander NEUMANN (Albuquerque, New Mexico); Payman ZARKESH-HA (Albuquerque, New Mexico) |
| ABSTRACT | An occupancy sensor covering a wide field in an integrated chip is disclosed. The occupancy sensor includes an array of grating coupled waveguide sensors wherein continuous wave (cw) signals monitor an ambient light field for dynamic changes on times scales of seconds, and high frequency signals map in three-dimensions of the space using time-of-flight (TOF) measurements, pixel level electronics that perform signal processing; array level electronics that perform additional signal processing; and communications and site level electronics that interface with actuators to respond to occupancy sensing. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238444 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/06 (20130101) Original (OR) Class G01J 1/44 (20130101) G01J 3/18 (20130101) G01J 3/0218 (20130101) G01J 3/0259 (20130101) G01J 3/1895 (20130101) G01J 3/2803 (20130101) G01J 2001/448 (20130101) Optical Elements, Systems, or Apparatus G02B 6/122 (20130101) G02B 6/124 (20130101) G02B 2006/12061 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1446 (20130101) H01L 31/103 (20130101) H01L 31/02019 (20130101) H01L 31/02164 (20130101) H01L 31/02327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262860 | Hu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juejun Hu (Newton, Massachusetts); Derek Kita (Cambridge, Massachusetts); Jerome Michon (Cambridge, Massachusetts) |
| ABSTRACT | A method of performing Raman spectroscopy can include guiding a Raman pump beam with an optical fiber, where the Raman pump beam inducing fluorescence in the optical fiber. The beam and the fluorescence are coupled to a photonic integrated circuit (PIC) via the fiber. The beam is used to excite a sample in optical communication with the PIC via evanescent coupling and induces Raman scattering in the sample. The Raman scattering is collected via the PIC, and the Raman pump beam as well as the fluorescence is filtered out from the Raman scattering via the PIC. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/243157 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) G01J 3/0205 (20130101) G01J 3/0218 (20130101) G01J 3/4406 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262969 | GALAGAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | James GALAGAN (Needham, Massachusetts); Uros KUZMANOVIC (Brookline, Massachusetts); Luis ORTIZ (Brookline, Massachusetts); Douglas DENSMORE (Malden, Massachusetts); Nicolas Shijie SHU (Levittown, New York) |
| ABSTRACT | Described herein are systems, assays, methods and compositions for identification of oxidase microbial redox-enzymes (MREs) specific to an analyte of interest from an environmental source. The technology relates to identification of analyte-responsive MREs that can quantify the concentration of a target analyte with high specificity and high sensitivity, for example, where the identified analyte-responsive redox-enzyme can be used to engineer an electrochemical biosensor. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/169171 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) C12Q 1/32 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3272 (20130101) Original (OR) Class G01N 27/3274 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263011 | MELLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit MELLER (Brookline, Massachusetts); Meni WANUNU (West Roxbury, Massachusetts) |
| ABSTRACT | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating of nanopores by: (1) self-assembly from solution, in which nanopores −10 nm diameter can be reproducibly coated, and (2) self-assembly under voltage-driven electrolyte flow, in which 5 nm nanopores may be coated. Applications of chemically modified nanopore are provided including: the detection of biopolymers such as DNA and RNA; immobilizing enzymes or other proteins for detection or for generating chemical gradients; and localized pH sensing. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/241929 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/48721 (20130101) Original (OR) Class G01N 2021/6439 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/2982 (20150115) Y10T 436/143333 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263051 | Seibel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Eric J. Seibel (Seattle, Washington); Leonard Y. Nelson (Seattle, Washington); Manuja Sharma (Seattle, Washington); Jasmine Graham (Seattle, Washington) |
| ABSTRACT | Systems and methods for accurate optical pH sensing of biofilms are disclosed. In one embodiment, a method of measuring an extracellular pH level using multiple wavelengths emitted by a fluorescent substance includes: exciting the fluorescent substance at an excitation wavelength; measuring a first fluorescence intensity at a first wavelength of a fluorescence emission; and measuring a second fluorescence intensity at a second wavelength of the fluorescence emission. The second wavelength is different from the first wavelength. The method also includes determining the extracellular pH level based on the first fluorescence intensity at the first wavelength and the second fluorescence intensity at the second wavelength. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/260957 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 33/52 (20130101) G01N 33/84 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263069 | BRUECK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven R.J. BRUECK (Albuquerque, New Mexico); Daniel FEEZELL (Albuquerque, New Mexico); John RANDALL (Albuquerque, New Mexico); Tito BUSANI (Albuquerque, New Mexico); Joshua B. BALLARD (Albuquerque, New Mexico); Mahmoud BEHZADIRAD (Albuquerque, New Mexico); Ashwin Krishnan RISHINARAMANGALAM (Albuquerque, New Mexico) |
| ABSTRACT | Provided is a composite metal-wide-bandgap semiconductor tip for scanning tunneling microscopy and/or scanning tunneling lithography, a method of forming, and a method for using the composite metal-wide-bandgap semiconductor tip. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237697 |
| CURRENT CPC | Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof B82B 3/0004 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/16 (20130101) Original (OR) Class G01Q 70/06 (20130101) G01Q 70/10 (20130101) G01Q 70/12 (20130101) G01Q 70/14 (20130101) G01Q 80/00 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263357 | de Pablo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan Jose de Pablo (Chicago, Illinois); Paul Franklin Nealey (Chicago, Illinois); Xiao Li (Chicago, Illinois); Jose A. Martinez-Gonzalez (Chicago, Illinois); Monirosadat Sadati (Chicago, Illinois); Rui Zhang (Chicago, Illinois); Ye Zhou (Chicago, Illinois) |
| ABSTRACT | Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/249646 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/00 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/137 (20130101) G02F 1/1393 (20130101) Original (OR) Class G02F 1/1396 (20130101) G02F 2201/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210263729 | Mayer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mikaël Mayer (Chicago, Illinois); Ravi Chugh (Chicago, Illinois) |
| ABSTRACT | A method of facilitating bidirectional programming of a user may include receiving an original program source code and evaluating the original program source code in the forward direction to generate a program output. The evaluation may occur in a programming environment. The program output may be displayed, and an indication of the user corresponding to modifying the program output may be received. The modified program output may be evaluated to generate an updated program source code, wherein the updated program source code, when evaluated, may generate the modified program output. The modified program output may be displayed in a display device of the user. A computing system including a bidirectional programming environment may also be included. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/227227 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/34 (20130101) G06F 8/71 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264012 | MARE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shrirang MARE (Seattle, Washington); David KOTZ (Lyme, New Hampshire); Ronald PETERSON (Brattleboro, Vermont) |
| ABSTRACT | A system and method for authenticating users of a digital device includes an authentication device attached to an authorized user. The authentication device includes one or more motion sensors and acts as a user identity token. To authenticate with a digital device, the user performs one or more interactions with the digital device using the hand associated with the authentication device. The digital device correlates the inputs received due to the interactions with the user's hand and/or wrist movement, as measured by the authentication device. Access to the digital device is allowed if the inputs and movements are correlated. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/261691 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/35 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264027 | VENKATARAMANI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guru Prasadh VENKATARAMANI (Fairfax, Virginia); Milo{hacek over (s)} DOROSLOVACKI (Washington, District of Columbia); Hongyu FANG (Bethesda, Maryland) |
| ABSTRACT | A system for defending against a side channel attack. The system includes a reuse distance buffer configured to measure one or more reuse distances for a microarchitecture block according to information of marker candidates and information of target events of a microarchitecture block; and a defense actuator configured to determine existence of a side channel attack in the microarchitecture block according to the one or more reuse distances for the microarchitecture block. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181197 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/554 (20130101) Original (OR) Class G06F 2221/034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264241 | Karanth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio University (Athens, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avinash Karanth (Canal Winchester, Ohio); Kyle Shiflett (Chillicothe, Ohio) |
| ABSTRACT | Processing elements for neural network accelerators, and methods of operating the processing elements. Each of a plurality of synapse lanes outputs an electrical signal indicative of a value of a synapse. Each electrical signal is received by a respective optical AND unit including an optical microring resonator that selectively couples an optical signal indicative of the value of an input neuron based at least in part on the received electrical signal. The output of each optical AND unit is provided to either an electrical multiply and accumulate unit, or a respective interferometer of a plurality of interferometers. The interferometers are arranged in series so that optical signals are sequentially summed and shifted by each interferometer. The last interferometer outputs a shifted and accumulated sum of the outputs received from the optical AND units. In either case, the accumulated sum may then be used to generate an output neuron. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178563 |
| CURRENT CPC | Electric Digital Data Processing G06F 5/01 (20130101) G06F 7/50 (20130101) G06F 7/523 (20130101) G06F 7/5443 (20130101) G06F 9/5027 (20130101) Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Original (OR) Class G06N 3/067 (20130101) G06N 3/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264902 | Larson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Clinc, Inc. (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan Larson (Ann Arbor, Michigan); Kevin Leach (Ann Arbor, Michigan); Michael A. Laurenzano (Ann Arbor, Michigan) |
| ABSTRACT | A system and method of implementing an intuitive search interface for tactically searching one or more annotated utterance corpora in a machine learning-based dialogue system includes identifying an utterance corpus query for searching one or more annotated utterance corpora of a machine learning-based dialogue system; interpreting the utterance corpus query by translating the utterance corpus query into one or more search expressions recognizable to an utterance sample retrieval program searchably interfacing with the one or more annotated utterance corpora of the machine learning-based dialogue system; retrieving one or more annotated utterance samples from the one or more annotated utterance corpora based on the interpretation of the utterance corpus query; and returning the one or more annotated utterance samples to an intuitive utterance corpus search interface. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/178052 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/16 (20130101) Original (OR) Class G10L 15/22 (20130101) G10L 15/063 (20130101) G10L 15/1822 (20130101) G10L 2015/223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210265236 — Chip Warpage Reduction Via Raised Free Bending & Re-entrant (Auxetic) Trace Geometries
| US 20210265236 | Huitink et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Fayetteville, Arkansas) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Fayetteville, Arkansas) |
| INVENTOR(S) | David Huitink (Prairie Grove, Arkansas); John Harris (Rogers, Arkansas) |
| ABSTRACT | A microelectronic device and method of making the same including a substrate and at least one expansion layer that adds stress to the substrate when said substrate expands. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313861 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 9/041 (20130101) B32B 2307/30 (20130101) B32B 2457/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/4882 (20130101) H01L 23/562 (20130101) H01L 23/3735 (20130101) Original (OR) Class H01L 24/24 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/24942 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210266122 | MELODIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tommaso MELODIA (Newton, Massachusetts); Giuseppe Enrico SANTAGATI (Cambridge, Massachusetts) |
| ABSTRACT | A system and method for transmitting data ultrasonically through biological tissue employs a network of a plurality of nodes, at least a portion of the nodes implantable within the biological tissue. At least one implanted node includes a transmitter having an orthogonal frequency division multiplex signal generator to encode an ultrasonic signal for transmission through the biological tissue to an ultrasonic receiver at another node. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/034217 |
| CURRENT CPC | Transmission H04B 11/00 (20130101) H04B 13/005 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0003 (20130101) H04L 1/0009 (20130101) H04L 1/0057 (20130101) H04L 5/0012 (20130101) Original (OR) Class H04L 27/0008 (20130101) H04L 27/2053 (20130101) H04L 27/2602 (20130101) H04L 27/2626 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20210259607 | Tcheng |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NeuroPace, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas K. Tcheng (Pleasant Hill, California) |
| ABSTRACT | A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313866 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0006 (20130101) A61B 5/0031 (20130101) A61B 5/165 (20130101) A61B 5/0205 (20130101) A61B 5/0261 (20130101) A61B 5/291 (20210101) Original (OR) Class A61B 5/316 (20210101) A61B 5/4082 (20130101) A61B 5/4094 (20130101) A61B 5/4839 (20130101) A61B 5/6868 (20130101) A61B 5/7278 (20130101) A61B 5/14553 (20130101) A61B 2562/028 (20130101) A61B 2562/046 (20130101) A61B 2562/063 (20130101) A61B 2562/0209 (20130101) A61B 2562/0285 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/0531 (20130101) A61N 1/0534 (20130101) A61N 1/36064 (20130101) A61N 1/36067 (20130101) A61N 1/36082 (20130101) A61N 1/36132 (20130101) A61N 1/36139 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210260562 | SHAIKH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | XPLOSAFE, LLC (Stillwater, Oklahoma) |
| ASSIGNEE(S) | XPLOSAFE, LLC (Stillwater, Oklahoma) |
| INVENTOR(S) | Shoaib F. SHAIKH (Stillwater, Oklahoma); Allen W. APBLETT (Stillwater, Oklahoma); Nicholas F. MATERER (Stillwater, Oklahoma); Evgueni KADOSSOV (Stillwater, Oklahoma); Michael L. TEICHEIRA (Stillwater, Oklahoma) |
| ABSTRACT | The present invention provides an improved sorbent and corresponding device(s) and uses thereof for the capture and stabilization of volatile organic compounds (VOC) or semi-volatile organic compounds (SVOC) from a gaseous atmosphere. The sorbent is capable of rapid and high uptake of one or more compounds and provides quantitative release (recovery) of the compound(s) when exposed to elevated temperature and/or organic solvent. Uses of particular improved grades of mesoporous silica are disclosed. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157526 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/106 (20130101) B01D 2257/708 (20130101) B01D 2259/4583 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) Original (OR) Class B01J 20/3204 (20130101) B01J 20/3219 (20130101) B01J 20/3246 (20130101) B01J 20/3293 (20130101) B01J 20/28021 (20130101) B01J 20/28064 (20130101) B01J 20/28073 (20130101) B01J 20/28076 (20130101) B01J 20/28083 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/18 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2004/04 (20130101) C01P 2004/13 (20130101) C01P 2006/12 (20130101) C01P 2006/14 (20130101) C01P 2006/16 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/0091 (20130101) C06B 23/00 (20130101) C06B 45/00 (20130101) Blasting F42D 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262077 | ZHANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Government of the United States of America as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheng ZHANG (Gaithersburg, Maryland); Wenqi ZHU (Vienna, Virginia); Amit Kumar AGRAWAL (Rockville, Maryland); David R. CARLSON (Boulder, Colorado); Henri LEZEC (Silver Spring, Maryland) |
| ABSTRACT | High-performance optical-metasurface-based platform configured with the use of Tantalum Pentoxide to operate with extremely low levels of loss at frequencies of UV light and, in particular, in mid- and near-UV ranges and performing multiple optical-wavefront-shaping functions (among which there are high-numerical-aperture lensing, accelerating beam generation, and hologram projection). Process of fabrication of such metasurface producing near-zero levels of optical loss and employing the otherwise standard etching methodologies. Embodiments facilitate the development of low-form-factor, multifunctional ultraviolet nanophotonic platforms based on flat optical components and enabling diverse applications including lithography, imaging, spectroscopy, and quantum information processing. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/315108 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/0036 (20130101) Original (OR) Class C23C 14/083 (20130101) C23C 14/3471 (20130101) C23C 14/5873 (20130101) Optical Elements, Systems, or Apparatus G02B 5/1866 (20130101) G02B 5/3075 (20130101) G02B 5/3091 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210262798 | Kitching et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Edward Kitching (Boulder, Colorado); Elizabeth Ann Donley (Boulder, Colorado); Azure Lynn Hansen (Louisville, Colorado); Yun-Jhih Chen (Boulder, Colorado) |
| ABSTRACT | An inertial point-source matter-wave atom interferometer gyroscope includes an analyzer that receives fringe images of gyroscope atoms and includes: a first fringe image that includes a first fringe phase, a second fringe image that includes a second fringe phase; and a third fringe image that includes a third fringe phase, wherein the first fringe phase, the second fringe phase, and the third fringe phase are different; a phase mapper of the analyzer that produces a interferometric phase map for the gyroscope atoms from the fringe images of the gyroscope atoms; and a fitter of the analyzer in communication with the phase mapper and that receives the interferometric phase map from the analyzer and determines inertial parameters of the gyroscope atoms from the interferometric phase map, the inertial parameters including an acceleration and a rotation rate of the inertial point-source matter-wave atom interferometer gyroscope relative to the gyroscope atoms. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/177895 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/0203 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/62 (20130101) Original (OR) Class G01C 19/64 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/093 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/12 (20130101) G21K 1/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210259179 | Klessig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Boyce Thompson Institute for Plant Research, Inc. (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel F. Klessig (Dryden, New York); Frank Schroeder (Itaca, New York); Patricia Manosalva (Ithaca, New York) |
| ABSTRACT | Compositions and methods for enhancing disease resistance in plants are disclosed. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306166 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 3/04 (20130101) Original (OR) Class Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/16 (20130101) A01N 43/38 (20130101) A01N 63/12 (20200101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8281 (20130101) C12N 15/8282 (20130101) C12N 15/8283 (20130101) C12N 15/8285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210259219 | Prather et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randall S. Prather (Rocheport, Missouri); Kevin D. Wells (Columbia, Missouri); Kristin M. Whitworth (Columbia, Missouri) |
| ABSTRACT | The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242963 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Original (OR) Class Peptides C07K 14/7056 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8509 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20210260562 | SHAIKH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | XPLOSAFE, LLC (Stillwater, Oklahoma) |
| ASSIGNEE(S) | XPLOSAFE, LLC (Stillwater, Oklahoma) |
| INVENTOR(S) | Shoaib F. SHAIKH (Stillwater, Oklahoma); Allen W. APBLETT (Stillwater, Oklahoma); Nicholas F. MATERER (Stillwater, Oklahoma); Evgueni KADOSSOV (Stillwater, Oklahoma); Michael L. TEICHEIRA (Stillwater, Oklahoma) |
| ABSTRACT | The present invention provides an improved sorbent and corresponding device(s) and uses thereof for the capture and stabilization of volatile organic compounds (VOC) or semi-volatile organic compounds (SVOC) from a gaseous atmosphere. The sorbent is capable of rapid and high uptake of one or more compounds and provides quantitative release (recovery) of the compound(s) when exposed to elevated temperature and/or organic solvent. Uses of particular improved grades of mesoporous silica are disclosed. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157526 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/106 (20130101) B01D 2257/708 (20130101) B01D 2259/4583 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) Original (OR) Class B01J 20/3204 (20130101) B01J 20/3219 (20130101) B01J 20/3246 (20130101) B01J 20/3293 (20130101) B01J 20/28021 (20130101) B01J 20/28064 (20130101) B01J 20/28073 (20130101) B01J 20/28076 (20130101) B01J 20/28083 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/18 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2004/04 (20130101) C01P 2004/13 (20130101) C01P 2006/12 (20130101) C01P 2006/14 (20130101) C01P 2006/16 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/0091 (20130101) C06B 23/00 (20130101) C06B 45/00 (20130101) Blasting F42D 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261272 | Washington, II et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | William J. Washington, II (North Potomac, Maryland); Christian Jordan (Baltimore, Maryland) |
| ABSTRACT | A bag unlocking method includes receiving, by a bag handling system, a bag during a check-in process. The bag handling system identifies, from a travel carrier system, traveler information corresponding to the bag. A securing device of the bag is programmed, using an unlock code pertaining to the traveler information. The bag handling system reads a bag tag of the bag at a baggage inspection station, and determines the unlock code pertaining to the bag tag. The bag handling system transmits the unlock code to cause the securing device to unlock at the baggage inspection station. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/182870 |
| CURRENT CPC | Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/366 (20130101) Original (OR) Class B64F 1/368 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210260057 | Bhowmick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Neil Bhowmick (Beverly Hills, California); Rajeev Mishra (Los Angeles, California); Bethany Smith (Lancaster, California) |
| ABSTRACT | The present disclosure provides compositions, markers, and methods for diagnosing and treating cancer and other conditions. The method includes administering at least one androgen deprivation therapy to the subject; and administering a therapeutically effective amount of at least one inhibitor to the subject, wherein the at least one inhibitor is selected from the group including: at least one macropinocytosis inhibitor, at least one glutamine metabolism inhibitor, at least one glutaminase inhibitor, and any combinations thereof. |
| FILED | Friday, July 12, 2019 |
| APPL NO | 17/257531 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/433 (20130101) A61K 31/501 (20130101) Original (OR) Class A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6812 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261497 | Sun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); The University of Pittsburgh - of the Commonwealth of Higher Education (Pittsburgh, Pennsylvania); Xiamen University (Xiamen, China PRC); University of Exeter (Exeter, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dandan Sun (Pittsburgh, Pennsylvania); Xianming Deng (Xiamen, Fujian, China PRC); Jinwei Zhang (Exeter, United Kingdom); Mohammad Iqbal Hossain Bhuiyan (Pittsburgh, Pennsylvania); Bradley J. Molyneaux (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/177056 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Acyclic or Carbocyclic Compounds C07C 255/44 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210260562 | SHAIKH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | XPLOSAFE, LLC (Stillwater, Oklahoma) |
| ASSIGNEE(S) | XPLOSAFE, LLC (Stillwater, Oklahoma) |
| INVENTOR(S) | Shoaib F. SHAIKH (Stillwater, Oklahoma); Allen W. APBLETT (Stillwater, Oklahoma); Nicholas F. MATERER (Stillwater, Oklahoma); Evgueni KADOSSOV (Stillwater, Oklahoma); Michael L. TEICHEIRA (Stillwater, Oklahoma) |
| ABSTRACT | The present invention provides an improved sorbent and corresponding device(s) and uses thereof for the capture and stabilization of volatile organic compounds (VOC) or semi-volatile organic compounds (SVOC) from a gaseous atmosphere. The sorbent is capable of rapid and high uptake of one or more compounds and provides quantitative release (recovery) of the compound(s) when exposed to elevated temperature and/or organic solvent. Uses of particular improved grades of mesoporous silica are disclosed. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157526 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/106 (20130101) B01D 2257/708 (20130101) B01D 2259/4583 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) Original (OR) Class B01J 20/3204 (20130101) B01J 20/3219 (20130101) B01J 20/3246 (20130101) B01J 20/3293 (20130101) B01J 20/28021 (20130101) B01J 20/28064 (20130101) B01J 20/28073 (20130101) B01J 20/28076 (20130101) B01J 20/28083 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/18 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2004/04 (20130101) C01P 2004/13 (20130101) C01P 2006/12 (20130101) C01P 2006/14 (20130101) C01P 2006/16 (20130101) Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 21/0091 (20130101) C06B 23/00 (20130101) C06B 45/00 (20130101) Blasting F42D 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210264902 | Larson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Clinc, Inc. (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan Larson (Ann Arbor, Michigan); Kevin Leach (Ann Arbor, Michigan); Michael A. Laurenzano (Ann Arbor, Michigan) |
| ABSTRACT | A system and method of implementing an intuitive search interface for tactically searching one or more annotated utterance corpora in a machine learning-based dialogue system includes identifying an utterance corpus query for searching one or more annotated utterance corpora of a machine learning-based dialogue system; interpreting the utterance corpus query by translating the utterance corpus query into one or more search expressions recognizable to an utterance sample retrieval program searchably interfacing with the one or more annotated utterance corpora of the machine learning-based dialogue system; retrieving one or more annotated utterance samples from the one or more annotated utterance corpora based on the interpretation of the utterance corpus query; and returning the one or more annotated utterance samples to an intuitive utterance corpus search interface. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/178052 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/16 (20130101) Original (OR) Class G10L 15/22 (20130101) G10L 15/063 (20130101) G10L 15/1822 (20130101) G10L 2015/223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 20210261749 | THORNBURG |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Earl THORNBURG (Denver, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes a lignin-derived mixture that includes at least one of a dimer, a trimer, and/or a tetramer, where the composition is characterized by a thermal stability up to a maximum temperature between about 260° C. and about 300° C. |
| FILED | Tuesday, September 01, 2020 |
| APPL NO | 17/008864 |
| CURRENT CPC | Separation B01D 3/14 (20130101) B01D 3/4227 (20130101) B01D 5/006 (20130101) B01D 5/009 (20130101) B01D 11/0488 (20130101) B01D 11/0492 (20130101) Compounds of Unknown Constitution C07G 1/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/22 (20130101) Original (OR) Class C08J 2397/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210261911 | BECKHAM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); UT-Battelle, LLC (Oak Ridge, Tennessee); Technical University of Denmark (Danmarks Tekniske Universitet) (Lyngby, Denmark) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregg Tyler BECKHAM (Golden, Colorado); Christopher W. JOHNSON (Denver, Colorado); Allison Jean ZIMONT WERNER (Denver, Colorado); Davinia SALVACHÚA RODRÍGUEZ (Golden, Colorado); Daniel A. JACOBSON (Oak Ridge, Tennessee); Erika TEIXEIRA PRATES (Oak Ridge, Tennessee); Elsayed Tharwat Tolba MOHAMED (Helsingborg, Sweden); Adam Michael FEIST (San Diego, California) |
| ABSTRACT | Disclosed herein are the genetically modified Pseudomonas with improved tolerance to hydroxycinnamic acids. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184580 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) Original (OR) Class C12N 15/78 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/38 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210265074 | MAJIDI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Carmel MAJIDI (Pittsburgh, Pennsylvania); Chengfeng PAN (Pittsburgh, Pennsylvania); Kitty KUMAR (Vancouver, Canada) |
| ABSTRACT | A stretchable and transparent electronic structure may generally include a stretchable elastomer layer; optionally, a metal adhesion layer on top of the stretchable elastomer layer; a metal alloying layer on top of the metal adhesion layer; and a liquid metal, wherein the structure is colorless and transparent when viewed under visible light. Methods of making the stretchable and transparent electronic structure are also described. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240281 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/04 (20130101) C25D 5/022 (20130101) C25D 5/54 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/12 (20130101) Original (OR) Class H01B 1/22 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0393 (20130101) H05K 2201/0108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20210263390 | BECK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kristin BECK (College Park, Maryland); Marko Cetina (College Park, Maryland); Michael Goldman (Washington, District of Columbia) |
| ABSTRACT | Aspects of the present disclosure describe techniques for controlling coherent crosstalk errors that occur in multi-channel acousto-optic modulators (AOMs) by applying cancellation tones to reduce or eliminate the crosstalk errors. For example, a method and systems are described that include applying a first radio frequency (RF) tone to generate a first acoustic wave in a first channel of the multi-channel AOM, wherein a portion of the first acoustic wave interacts with a second channel to cause a crosstalk effect, and applying a second RF tone to generate a second acoustic wave in the second channel, wherein the second acoustic wave reduces or eliminates the crosstalk effect caused by the portion of the first acoustic wave. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150909 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/113 (20130101) G02F 1/332 (20130101) Original (OR) Class Multiplex Communication H04J 14/0213 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
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THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, August 26, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
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FUNDED BY
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Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page