FedInvent™ Patent Applications
Application Details for Thursday, September 02, 2021
This page was updated on Friday, September 03, 2021 at 12:33 AM GMT
Department of Health and Human Services (HHS)
| US 20210267455 | Ghadimi et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sona Ghadimi (Charlottesville, Virginia); Changyu Sun (Charlottesville, Virginia); Xue Feng (Zion Crossroads, Virginia); Craig H. Meyer (Charlottesville, Virginia); Frederick H. Epstein (Charlottesville, Virginia) |
| ABSTRACT | A method of cardiac strain analysis uses displacement encoded magnetic resonance image (MRI) data of a heart of the subject and includes generating a phase image for each frame of the displacement encoded MRI data. Phase images include potentially phase-wrapped measured phase values corresponding to pixels of the frame. A convolutional neural network CNN computes a wrapping label map for the phase image, and the wrapping label map includes a respective number of phase wrap cycles present at each pixel in the phase image. Computing an unwrapped phase image includes adding a respective phase correction to each of the potentially-wrapped measured phase values of the phase image, and the phase correction is based on the number of phase wrap cycles present at each pixel. Computing myocardial strain follows by using the unwrapped phase image for strain analysis of the subject. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166604 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0044 (20130101) Original (OR) Class A61B 5/055 (20130101) A61B 5/02028 (20130101) A61B 5/7267 (20130101) A61B 5/7278 (20130101) A61B 2576/023 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/56 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267457 | Liu et al. |
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| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Xuan Liu (Berkeley Heights, New Jersey); Yahui Wang (Harrison, New Jersey) |
| ABSTRACT | An optically computed optical coherence tomography (OC-OCT) technology is disclosed. The OC-OCT system performs depth resolved imaging by computing the Fourier transform of the interferometric spectra optically. The OC-OCT system modulates the interferometric spectra with Fourier basis function projected to a spatial light modulator and detects the modulated signal without spectral discrimination. The optical computation strategy enables volumetric OCT imaging without performing mechanical scanning and without the need for Fourier transform in a computer. OC-OCT performs Fourier transform signal processing optically, without the need of mechanical scanning, and before data acquisition unlike traditional OCT methods and systems. The scan-less OCT imaging is achieved through the use of spatial light modulator (SLM) that precisely manipulates light wave to generate output with desired amplitude and phase. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185182 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/0066 (20130101) Original (OR) Class A61B 5/0261 (20130101) A61B 5/7257 (20130101) Optical Computing Devices; G06E 1/04 (20130101) Electric Digital Data Processing G06F 17/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267516 | Gazzaley |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Gazzaley (San Francisco, California) |
| ABSTRACT | Provided are methods of enhancing the performance of a subject on a cognitive task by improved self-regulation of internal distraction. The methods include presenting a computer-based cognitive training program to a subject, where performance of the subject on the cognitive task is enhanced by the cognitive training program. Computer readable media and devices useful for practicing the methods of the present disclosure are also provided. |
| FILED | Wednesday, December 09, 2020 |
| APPL NO | 17/116408 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/38 (20210101) A61B 5/168 (20130101) Original (OR) Class A61B 5/375 (20210101) A61B 5/378 (20210101) A61B 5/486 (20130101) A61B 5/6803 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/06 (20130101) G09B 7/02 (20130101) G09B 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267550 | Mukkamala et al. |
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| APPLICANT(S) | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan) |
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| INVENTOR(S) | Ramakrishna Mukkamala (Okemos, Michigan); Anad CHANDRASEKHAR (East Lansing, Michigan); Keerthana Natarajan (East Lansing, Michigan); Mohammad Yavarimanesh (Lansing, Michigan) |
| ABSTRACT | Various systems, techniques, and embodiments are disclosed for implementing a blood-pressure measurement method that does not require specialized equipment (such as inflatable blood pressure cuffs). The measurement can be taken from arterial locations within a user's finger, via the standard equipment and features of many widely-available consumer mobile devices. Such devices can be programmed to accurately and easily guide a user to press her finger on the screen of a device at a precise location, so that an accurate measurement can be taken. For example, guidance visualizations on a screen (such as finger silhouettes and animations) can be employed on the same screen on which a user presses her finger. Pressure sensitivity and optical camera readings are then used to calculate blood pressure for the user. |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/256609 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0295 (20130101) A61B 5/743 (20130101) A61B 5/1075 (20130101) A61B 5/02225 (20130101) A61B 5/6898 (20130101) Original (OR) Class Electric Digital Data Processing G06F 3/044 (20130101) Wireless Communication Networks H04W 88/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267573 | Reiche et al. |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
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| INVENTOR(S) | Christopher F. Reiche (Salt Lake City, Utah); Florian Solzbacher (Salt Lake City, Utah); Navid Farhoudi (Salt Lake City, Utah); Steven M. Blair (Salt Lake City, Utah); Jules J. Magda (Salt Lake City, Utah); Lars B. Laurentius (Cottonwood Heights, Utah); Prattay Deepta Kairy (Salt Lake City, Utah) |
| ABSTRACT | Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/315039 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/4272 (20130101) Original (OR) Class A61B 8/4483 (20130101) A61B 8/5207 (20130101) A61B 2562/028 (20130101) A61B 2562/0204 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267577 | Trzasko et al. |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua D. Trzasko (Rochester, Minnesota); Shigao Chen (Rochester, Minnesota); Chengwu Huang (Rochester, Minnesota); Pengfei Song (Champaign, Illinois); Armando Manduca (Rochester, Minnesota) |
| ABSTRACT | Systems and methods for removing the bias induced by noise from power Doppler images to achieve improvements of microvessel image contrast are provided. In one example, the noise-induced bias can be suppressed by utilizing the characteristics of uncorrelated noise in the ultrasound image from data acquired or compounded at different transmitting angles. In another example, the noise-induced bias can be suppressed due to the lack of correlation between adjacent ultrasound images. These example implementations may also be combined, as will be described below. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/260793 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) A61B 8/488 (20130101) A61B 8/5207 (20130101) A61B 8/5269 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267614 | Jiang et al. |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
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| INVENTOR(S) | Xiaoning Jiang (Cary, North Carolina); Howuk Kim (Raleigh, North Carolina) |
| ABSTRACT | A multi-pillar piezoelectric stack (MPPS) ultrasound transducer includes N pillars, each formed of a stack of M piezoelectric elements, N and M being integers of at least two. The ultrasound transducer further includes a bonding layer between each pair of the M piezoelectric elements. The pillars are laterally spaced from each other to form an inter-pillar gap. The transducer further includes at least one electrical interconnect for connecting the ultrasound transducer to a signal source. Through the MPPS design, the therapeutic range and the transducer sensitivity are increased over the conventional single pillar piezoelectric stack (SPPS) transducer design. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198926 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/2202 (20130101) Original (OR) Class A61B 2017/00402 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267696 | Degertekin et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
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| INVENTOR(S) | Fahrettin Levent Degertekin (Atlanta, Georgia); Ozgur Kocaturk (Rockville, Illinois); Yusuf S. Yaras (Atlanta, Georgia) |
| ABSTRACT | Certain implementations of the disclosed technology may include active marker devices, retrofits, systems, and methods for determining the position of interventional devices under MRI. A marker device is provided that utilizes an optical fiber, an acousto-optical sensor region that includes an electro-mechanical conversion assembly, and one or more antenna(e). The one or more antennae are configured to receive MRI radio-frequency (RF) electromagnetic energy and produce a corresponding electrical signal corresponding to the position. The acousto-optical sensor region may include a resonator and may be modulated by acoustic waves generated responsive to the electrical signal received from the one or more antennae. The acousto-optical sensor region may be interrogated by light via the optical fiber to determine the position of the device for providing an active marker in the MRI image. |
| FILED | Tuesday, July 09, 2019 |
| APPL NO | 17/258806 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/05 (20130101) A61B 5/055 (20130101) A61B 5/065 (20130101) A61B 5/0097 (20130101) A61B 34/20 (20160201) Original (OR) Class A61B 90/39 (20160201) A61B 2034/2051 (20160201) A61B 2034/2061 (20160201) A61B 2034/2063 (20160201) A61B 2090/3958 (20160201) A61B 2090/3987 (20160201) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0105 (20130101) A61M 25/0108 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/287 (20130101) G01R 33/3692 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267746 | MacEwan et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
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| INVENTOR(S) | Matthew R. MacEwan (St. Louis, Missouri); Jingwei Xie (Chesapeake, Ohio); Zack Ray (St. Louis, Missouri); Younan Xia (Atlanta, Georgia) |
| ABSTRACT | A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229171 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/02 (20130101) Original (OR) Class A61F 2/0063 (20130101) A61F 2/105 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/22 (20130101) A61L 15/42 (20130101) A61L 27/14 (20130101) A61L 27/50 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/05 (20190201) B29C 48/142 (20190201) Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0076 (20130101) D01D 5/0092 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/728 (20130101) D04H 3/016 (20130101) D04H 3/073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267893 | Haraszti et al. |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
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| INVENTOR(S) | Reka Agnes Haraszti (Shrewsbury, Massachusetts); Anastasia Khvorova (Westborough, Massachusetts); Neil Aronin (Newtonville, Massachusetts) |
| ABSTRACT | Novel artificial exosomes and methods for producing novel artificial exosomes are provided. Methods of delivering cargo molecules to a cell using artificial exosomes are also provided. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 31/7115 (20130101) A61K 31/7125 (20130101) A61K 35/17 (20130101) A61K 38/1719 (20130101) A61K 38/1741 (20130101) A61K 47/28 (20130101) A61K 47/62 (20170801) A61K 47/6917 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2310/313 (20130101) C12N 2310/321 (20130101) C12N 2310/3183 (20130101) C12N 2310/3231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267894 | LIN et al. |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Chenxiang LIN (Orange, Connecticut); Yang YANG (Watertown, Massachusetts) |
| ABSTRACT | A method for producing uniform-size liposomes is provided. The liposomes are coated with a sorting agent to yield a plurality of density-modified liposomes of different sizes. These liposomes are then separated using a densitometric method. The sorting agent includes both a density-modifying moiety and a targeting moiety. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162008 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) Original (OR) Class A61K 9/1277 (20130101) A61K 47/6913 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267897 | Unger |
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| APPLICANT(S) | Genesegues, Inc. (Chaska, Minnesota) |
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| INVENTOR(S) | Gretchen M. Unger (Chaska, Minnesota) |
| ABSTRACT | Disclosed are targeted sub-50 nanometer nanoparticles suitable for delivering bioactive agents of interest, and related compositions, methods, and systems, which improve the manufacturing, stability, efficacy and other aspects of therapeutic nanoparticles. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/239510 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/141 (20130101) Original (OR) Class A61K 9/1075 (20130101) A61K 9/5161 (20130101) A61K 9/5169 (20130101) A61K 31/7088 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267919 | Szewczyk et al. |
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| APPLICANT(S) | BioKier, Inc. (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | BioKier, Inc. (Chapel Hill, North Carolina) |
| INVENTOR(S) | Jerzy Ryszard Szewczyk (Chapel Hill, North Carolina); Nicolas D. Kirkland (Norristown, Pennsylvania); Troy A. Bartron, JR. (Ardmore, Pennsylvania); Abdul Waseh Basit (Harrow, United Kingdom) |
| ABSTRACT | The present invention relates to coated butyrate and butyrate plus DPP-IV inhibitor tablets. It has been discovered that an inner butyrate core, a first layer neutral polymer which can dissolve in the colon, followed by an outer coating of a composition, which dissolves only in the colon, prevents the interaction of butyrate with these compositions. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 16/805080 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5026 (20130101) A61K 9/5042 (20130101) A61K 31/19 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267932 | JALA et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (Louisville, Kentucky); THE INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (INSTEM) (Bangalore, India) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky); The Institute for Stem Cell Biology and Regenerative Medicine (InStem) (Bangalore, India) |
| INVENTOR(S) | Venkatakrishna Rao JALA (Louisville, Kentucky); Haribabu BODDULURI (Louisville, Kentucky); Rajbir SINGH (Louisville, Kentucky); Praveen Kumar VEMULA (Bangalore, India); Sandeep CHANDRASHEKHARAPPA (Bangalore, India); Ankita Arun HIWALE (Bangalore, India) |
| ABSTRACT | In some embodiments of the invention, inventive compounds (e.g., Formula (I), (IA), (II), and (III), and urolithin derivatives) are disclosed. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein. |
| FILED | Tuesday, May 14, 2019 |
| APPL NO | 17/053811 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 1/16 (20180101) A61P 35/00 (20180101) A61P 37/06 (20180101) Heterocyclic Compounds C07D 311/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267939 | NEWGARD et al. |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher B. NEWGARD (Durham, North Carolina); Phillip WHITE (Durham, North Carolina); Thomas GRENIER-LAROUCHE (Durham, North Carolina) |
| ABSTRACT | The present invention relates to compositions and methods for the treatment of NAFLD. Specifically, the present invention relates to compositions comprising one or more BCDKH agonists and methods of using the same for the treatment of NAFLD. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/254119 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267943 | Stamler |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
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| INVENTOR(S) | Jonathan S. Stamler (Cleveland, Ohio) |
| ABSTRACT | A method for preventing or treating a tissue injury and/or promoting tissue repair in a subject in need thereof, includes administering to the subject a therapeutically effective amount of an ADH inhibitor, AKR inhibitor, SCoR inhibitor, and/or PKM2 inhibitor. |
| FILED | Tuesday, June 25, 2019 |
| APPL NO | 17/256066 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/422 (20130101) A61K 31/424 (20130101) A61K 31/497 (20130101) A61K 31/506 (20130101) A61K 31/4166 (20130101) Original (OR) Class A61K 31/4178 (20130101) A61K 31/4439 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267965 | ABBOTT et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Geoffrey W. ABBOTT (IRVINE, California); Rian W. MANVILLE (IRVINE, California) |
| ABSTRACT | A method of activating heteromeric KCNQ2/3, KCNQ3/5, or KCNQ4/5 voltage-gated potassium channels in a cell membrane is described, as are compositions for use with same, as well as methods of reducing neuronal excitability and of ameliorating symptoms of epilepsy, anxiety, neuropathic pain, hypertension, cardiovascular disease, a neurodegenerative disorder, alcohol withdrawal, cancer, inflammation, or ophthalmic disease in a subject. These KCNQ2/3 (or KCNQ3/5 or KCNQ4/5) channels are heteromers that comprise KCNQ2 (or KCNQ5) subunits and KCNQ3 (or KCNQ4) subunits. In one embodiment, the method comprises: (a) contacting the cell membrane with a first agent that binds a KCNQ2 (or KCNQ5) subunit; and (b) contacting the cell membrane with a second agent that binds a KCNQ3 (or KCNQ4) subunit. |
| FILED | Thursday, July 18, 2019 |
| APPL NO | 17/260796 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/27 (20130101) A61K 31/195 (20130101) A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/353 (20130101) A61K 31/555 (20130101) A61K 31/4748 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267978 | Stockwell et al. |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
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| INVENTOR(S) | Brent R. Stockwell (New York, New York); Yan Zhang (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, nanoparticle formulations comprising nanoparticles of a polymer loaded with a system xc− inhibitor, such as a nanoparticle formulation comprising nanoparticles of PEG-PLGA loaded with IKE or a pharmaceutically acceptable salt thereof. Methods of preparing such nanoparticle formulations, methods of treating cancers in a subject or selectively killing cancer cells using such nanoparticle formulations, and kits comprising such nanoparticle formulations are also provided. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307605 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1641 (20130101) A61K 9/1647 (20130101) A61K 9/1694 (20130101) A61K 31/282 (20130101) A61K 31/337 (20130101) A61K 31/475 (20130101) A61K 31/495 (20130101) A61K 31/513 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/573 (20130101) A61K 31/655 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/5545 (20170801) A61K 31/7048 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 38/14 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267987 | SHAPIRO et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul S. SHAPIRO (Baltimore, Maryland); Alexander D. MACKERELL, JR. (Baltimore, Maryland); Jeffrey D. HASDAY (Timonium, Maryland) |
| ABSTRACT | Compounds that inhibit p38α MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231598 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/54 (20130101) A61K 31/5375 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) A61P 29/00 (20180101) A61P 31/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267991 | Zhao et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jean Zhao (Brookline, Massachusetts); Johann Bergholz (Cambridge, Massachusetts); Gordon J. Freeman (Brookline, Massachusetts); Thomas M. Roberts (Cambridge, Massachusetts) |
| ABSTRACT | The present invention relates to methods for treating PTEN deficient epithelial cancers using a combination of anti-PI3Kbeta and anti-immune checkpoint agents. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/173897 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2227/105 (20130101) A01K 2267/0331 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/5377 (20130101) Original (OR) Class A61K 31/7105 (20130101) A61K 45/06 (20130101) A61K 47/6803 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/32 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268007 | Lothstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Paradox Pharmaceuticals, Inc. (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leonard Lothstein (Eads, Tennessee); Judith Soberman (Eads, Tennessee); Tiffany N. Seagroves (Memphis, Tennessee) |
| ABSTRACT | The present invention relates to compositions comprising at least one of pivarubicin and benzarubicin, or a pharmaceutically acceptable salt thereof, and methods for using the compositions in the treatment of triple negative breast cancer (TNBC) by administering an effective amount of the compositions to a subject. In some instances, the subject is a mammal, including at least one of human, feline, and canine mammals. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/190317 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) Original (OR) Class A61K 47/02 (20130101) A61K 47/10 (20130101) A61K 47/14 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268008 | Falk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Children's Hospital of Philadelphia (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marni J. Falk (Philadelphia, Pennsylvania); Eiko Nakamaru-Ogiso (Philadelphia, Pennsylvania) |
| ABSTRACT | Compositions and methods for treatment of mitochondrial respiratory chain dysfunction and other mitochondrial disorders are provided. Also disclosed are a number of screening assays having utility for the identification of agents which modulate the phenotype associated with mitochondrial respiratory chain dysfunction. |
| FILED | Thursday, June 27, 2019 |
| APPL NO | 17/256406 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/10 (20130101) A61K 31/145 (20130101) A61K 31/198 (20130101) A61K 31/455 (20130101) A61K 31/7004 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) G01N 2333/43534 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268016 | STRITTMATTER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | STEPHEN M. STRITTMATTER (Durham, Connecticut); Erik Christian GUNTHER (Branford, Connecticut); Levi M. SMITH (Branford, Connecticut) |
| ABSTRACT | The disclosure provides polymeric compounds that inhibit binding of an amyloid-β-oligomer to cellular prion protein, methods for identifying such compounds, and their therapeutic use. In particular, the present disclosure provides a collection of anionic polymers and methods of using these compounds to treat amyloid-related disorders, e.g., Alzheimer's disease. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/258357 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/64 (20130101) A61K 31/78 (20130101) A61K 31/80 (20130101) A61K 31/155 (20130101) A61K 31/195 (20130101) A61K 31/198 (20130101) A61K 31/785 (20130101) A61K 31/787 (20130101) A61K 31/795 (20130101) Original (OR) Class A61K 36/16 (20130101) A61K 38/26 (20130101) A61K 38/28 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268020 | ERUSLANOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evgeniy ERUSLANOV (Havertown, Pennsylvania); Steven Albelda (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods that provide novel anti-tumor therapies in cancer. In one aspect, the present invention features a hybrid neutrophil in a non-naturally occurring container, wherein the hybrid neutrophil expresses at least one neutrophil associated molecule selected from the group consisting of: Arg1, MPO, CD66b, and CD15, and at least one antigen-presenting cell (APC) associated molecule selected from the group consisting of: CD14, HLA-DR, CD32, CD64, and CD89. In another aspect, the present invention features methods of generating a hybrid neutrophil. In still another aspect, the present invention features methods of inhibiting tumor growth in a subject, treating a tumor in a subject, and increasing efficacy of an antibody against a tumor in a subject. The methods comprise (a) administering to the subject an effective amount of an anti-tumor antibody and (b) administering to or generating in the subject an effective amount of a hybrid neutrophil. |
| FILED | Tuesday, December 15, 2020 |
| APPL NO | 17/122521 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 35/15 (20130101) Original (OR) Class A61K 38/193 (20130101) A61K 38/217 (20130101) A61K 39/0011 (20130101) A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2039/572 (20130101) A61K 2039/585 (20130101) A61K 2039/5158 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0642 (20130101) C12N 2501/22 (20130101) C12N 2501/24 (20130101) C12N 2501/599 (20130101) C12N 2502/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268024 | ROYBAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kole T. ROYBAL (San Francisco, California); Raymond Liu (San Francisco, California); Iowis Zhu (San Francisco, California) |
| ABSTRACT | The present disclosure generally relates to, inter alia, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. In addition, the new receptors described herein incorporate an extracellular oligomerization domain to promote oligomer formation of the chimeric receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as cancers. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217618 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/705 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 16/32 (20130101) C07K 16/2803 (20130101) C07K 16/2878 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268036 | Hsiao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elaine Y. Hsiao (Los Angeles, California); Thomas Fung (Los Angeles, California) |
| ABSTRACT | Provided herein are methods and compositions related to promoting or reducing colonization of spore-forming bacteria in a patient's gut, comprising administering a serotonin receptor agonist or a selective serotonin reuptake inhibitor, respectively. In some aspects, provided herein are methods of modulating lipid and steroid metabolism. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168944 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/742 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268045 | Aroian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raffi Van Aroian (Worcester, Massachusetts); Yan Hu (Shrewsbury, Massachusetts) |
| ABSTRACT | Compositions and methods for treating or reducing the severity or likelihood of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering to the subject a therapeutically effective amount of a recombinant bacterium expressing a crystal protein such as a Bacillus thuringiensis crystal protein (Cry). The crystal proteins may be full length, truncated, variant, or sub-variant Cry proteins. Examples of crystal proteins include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A. The recombinant bacterium may be, for example, a Bacillus subtilis or other Gram-positive bacterium, for instance, a lactic acid fermenting bacterium such as Lactococcus or Lactobacillus. Related compositions and recombinant microorganisms are also described. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/160030 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/506 (20130101) A61K 35/742 (20130101) A61K 35/744 (20130101) A61K 35/747 (20130101) Original (OR) Class A61K 38/164 (20130101) A61K 45/06 (20130101) A61K 2035/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268050 | MCFADDEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona board of regents on behalf of Arizona state university (Bcottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas Grant MCFADDEN (Tempe, Arizona); John CHRISTIE (Portage, Michigan); Joseph BLATTMAN (Scottsdale, Arizona); Mohammed Masmudur RAHMAN (Chandler, Arizona) |
| ABSTRACT | Disclosed herein, in certain embodiments, is a method of inhibiting or treating a cancer with use of a TNF expressing myxoma virus. Also disclosed herein are methods of inhibiting or treating a cancer with use of a mononuclear peripheral blood cells and/or a bone marrow cells treated with a TNF-expressing myxoma virus. Some aspects relate to engineered myxoma virus and pharmaceutical compositions for use with one or more of the methods described herein. |
| FILED | Friday, July 12, 2019 |
| APPL NO | 17/259849 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/14 (20130101) A61K 35/28 (20130101) A61K 35/768 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268061 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ONCOIMMUNE, INC. (Rockville, Maryland); UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| ASSIGNEE(S) | ONCOIMMUNE, INC (Rockville, Maryland); UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| INVENTOR(S) | Yang Liu (Baltimore, Maryland); Pan Zheng (Baltimore, Maryland); Martin Devenport (Gaithersburg, Maryland) |
| ABSTRACT | The present invention relates to the use of a CD24 protein for preventing or treating relapse of a cancer in a subject. The present invention also relates to the use of a CD24 protein for reducing cancer stem cell activity. |
| FILED | Monday, June 03, 2019 |
| APPL NO | 15/734957 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) Original (OR) Class A61K 2039/545 (20130101) Peptides C07K 14/70596 (20130101) C07K 16/4241 (20130101) C07K 2317/41 (20130101) C07K 2317/53 (20130101) C07K 2317/524 (20130101) C07K 2317/526 (20130101) C07K 2317/528 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268066 | Ji et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Ru-Rong Ji (Durham, North Carolina); Gang Chen (Durham, North Carolina); Zilong Wang (Durham, North Carolina); Changyu Jiang (Durham, North Carolina); Kaiyuan Wang (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides methods and kits for treating pain. More particularly, the present disclosure relates to methods of using PD-L1/PD-1-associated compounds to treat pain and/or bone destruction from bone cancer, and associated kits. The present disclosure also provides methods to assess the efficacy of compounds to suppress PD-1-associated nociceptive neuron activity. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317333 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4824 (20130101) A61B 5/4848 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) A61K 38/1774 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/04 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268067 | Embree et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mildred Embree (New York, None); Mo Chen (Rochester, None) |
| ABSTRACT | A composition for treating TMJ degeneration comprising a hydrogel of sclerostin and high molecular weight hyaluronic acid, or PLGA-encapsulated sclerostin, or sclerostin covalently linked to hyaluronic acid. |
| FILED | Wednesday, June 19, 2019 |
| APPL NO | 17/253993 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/5031 (20130101) A61K 31/728 (20130101) A61K 38/18 (20130101) Original (OR) Class A61K 47/61 (20170801) A61K 47/64 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268070 | SHAFIKHANI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rush University Medical Center (Chicago, Illinois) |
| ASSIGNEE(S) | Rush University Medical Center (Chicago, Illinois) |
| INVENTOR(S) | Sasha Hadi SHAFIKHANI (Elmwood Park, Illinois) |
| ABSTRACT | Methods and compositions are provided for treating an infection and promoting wound healing. The methods include administering an immunomodulator. In some aspects, the immunomodulator may be combined with an antibiotic. |
| FILED | Wednesday, July 10, 2019 |
| APPL NO | 17/258248 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/739 (20130101) A61K 38/06 (20130101) A61K 38/193 (20130101) A61K 38/195 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268081 | Cantor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Harvey Cantor (Boston, Massachusetts); Hye-Jung Kim (Brookline, Massachusetts); Jianmei Wu Leavenworth (Hoover, Alabama) |
| ABSTRACT | Nanoparticles to treat autoimmune diseases and HIV infection are provided. The nanoparticles comprise a biocompatible polymer and a complex, wherein the complex is a major histocompatibility complex (MHC) class I antigen E (HLA-E) linked to a peptide, and wherein the HLA-E-peptide complex is linked to the surface of the nanoparticle. The present invention also relates to methods for treating autoimmune diseases and HIV infection. |
| FILED | Wednesday, December 18, 2019 |
| APPL NO | 16/719814 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0008 (20130101) Original (OR) Class A61K 2039/58 (20130101) A61K 2039/5154 (20130101) A61K 2039/5158 (20130101) A61K 2039/55555 (20130101) Peptides C07K 14/47 (20130101) C07K 14/70539 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2501/2315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268088 | Janda |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kim D. Janda (La Jolla, California) |
| ABSTRACT | An improved heroin conjugate vaccine is detailed; to accomplish this task the systematic exploration of twenty vaccine formulations with varying combinations of carrier proteins and adjuvants were undertaken. In regard to adjuvants, a Toll-like receptor 9 (TLR9) agonist and a TLR3 agonist in the presence of alum were explored. The vaccine formulations containing TLR3 or TLR9 agonist alone-elicited strong anti-heroin antibody titers and blockade of heroin-induced antinociception when formulated with alum; however, a combination of TLR3 and 9 adjuvants did not result in improved efficacy. Investigation of stability of the two lead formulations revealed that the TLR9 but not the TLR3 formulation was stable when stored over 30 days. Furthermore, mice immunized with the TLR9+alum heroin vaccine gained significant protection from lethal heroin doses, suggesting that this vaccine formulation is suitable for mitigating the lethal effects of heroin, even following long-term storage at room temperature. |
| FILED | Thursday, November 08, 2018 |
| APPL NO | 16/761012 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 39/0013 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 47/26 (20130101) A61K 47/54 (20170801) A61K 47/643 (20170801) A61K 47/646 (20170801) A61K 47/6415 (20170801) A61K 2039/6037 (20130101) A61K 2039/6081 (20130101) A61K 2039/55505 (20130101) A61K 2039/55561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268090 | BEG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (TAMPA, Florida); MEMGEN, LLC (HOUSTON, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | AMER A. BEG (TAMPA, Florida); SCOTT J. ANTONIA (DURHAM, North Carolina); MARK J. CANTWELL (SAN DIEGO, California) |
| ABSTRACT | The invention concerns APCs, such as DCs, comprising a combination of an exogenous type I interferon and an exogenous CD40-L or one or more heterologous nucleic acid sequences encoding a combination of an exogenous type I IFN and an exogenous CD40-L, such as a combination of IFNβ and CD40-L; and methods for treating a malignancy by administering such APCs to a subject in need thereof. In certain embodiments, a subject is treated with an irradiation therapy before administering the APCs, such as DCs, of the invention. The invention also concerns an oncolytic virus comprising a combination of a type I IFN and CD40-L or one or more nucleic acid sequences encoding a combination of a type I IFN and CD40-L, such as a combination of IFNβ and CD40-L; and methods for treating a malignancy by administering such oncolytic virus to a subject in need thereof. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/253927 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) A61K 35/28 (20130101) A61K 35/761 (20130101) A61K 39/001111 (20180801) Original (OR) Class A61K 39/001141 (20180801) A61K 2039/585 (20130101) A61K 2039/5154 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/56 (20130101) C07K 14/70578 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) C12N 7/00 (20130101) C12N 2510/00 (20130101) C12N 2710/10321 (20130101) C12N 2710/10332 (20130101) C12N 2710/10343 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268092 | Putnam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Putnam (Ithaca, New York); Joseph Rosenthal (Ithaca, New York); Chung-Jr Huang (Newbury Park, California); Matthew DeLisa (Ithaca, New York); Susana Mendez (Silver Spring, Maryland) |
| ABSTRACT | The present invention relates to a probiotic cell transformed with a construct suitable to overexpress and display on the surface of the probiotic cell a fusion protein comprising at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides. Probiotic-derived vesicles displaying this fusion protein as well as methods of inducing an immune response using the probiotic cells or vesicles are also disclosed. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139280 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/164 (20130101) A61K 39/04 (20130101) A61K 39/12 (20130101) A61K 39/015 (20130101) Original (OR) Class A61K 39/35 (20130101) A61K 39/38 (20130101) A61K 39/39 (20130101) A61K 39/145 (20130101) A61K 2039/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268097 | OH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| ASSIGNEE(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| INVENTOR(S) | SangKon OH (Baltimore, Maryland); Sandra ZURAWSKI (Midlothian, Texas); Gerard ZURAWSKI (Midlothian, Texas) |
| ABSTRACT | Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/194779 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/395 (20130101) A61K 39/3955 (20130101) A61K 39/39541 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/005 (20130101) C07K 16/2878 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268098 | Frolova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UAB Research Foundation (Birmingham, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elena I. Frolova (Birmingham, Alabama); IIya V. Frolov (Birmingham, Alabama) |
| ABSTRACT | The present invention provides an attenuated Old World alphavirus particle and methods of making same and using same as a vaccine and in gene therapy and immunotherapy methods. |
| FILED | Friday, August 02, 2019 |
| APPL NO | 17/264377 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/1808 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268103 | Brewer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew G. Brewer (Rochester, New York); Lisa A. Beck (Rochester, New York); Brian M. Ward (Rochester, New York); Benjamin L. Miller (Rochester, New York) |
| ABSTRACT | This invention relates to dermatology and to treatments of infectious skin disease. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236099 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 39/39 (20130101) A61K 39/285 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/525 (20130101) Peptides C07K 16/244 (20130101) C07K 16/2866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268121 | He |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Kansas (Lawrence, Kansas); Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mei He (Gainesville, Florida) |
| ABSTRACT | Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236561 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6901 (20170801) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/54333 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268126 | Cai et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Li Cai (Warren, New Jersey); Misaal Patel (Avenel, New Jersey); Yi Lisa Lyu (Warren, New Jersey) |
| ABSTRACT | Methods for treating a neurological disorder, such as a traumatic spinal cord injury or traumatic brain injury, or a disorder such as Parkinson's disease or multiple sclerosis are provided. Such methods include administering a therapeutically effective amount of Gsx1 protein (such as a Gsx1-cell penetrating peptide fusion protein), or a nucleic acid molecule encoding such a protein (for example as part of a viral vector), thereby treating the neurological disorder. |
| FILED | Friday, August 16, 2019 |
| APPL NO | 17/268664 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/1709 (20130101) A61K 47/6455 (20170801) A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268128 | Harmsen |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan Harmsen (Menlo Park, California) |
| ABSTRACT | Biodegradable fluorescent silica nanoparticle (FSN) are provided for in vivo imaging, particularly of cancerous and precancerous lesions in the gastrointestinal tract. The FSN are comprised of (a) a dye that fluoresces in the near infrared spectrum which is (i) covalently joined to a silane, and (ii) distributed throughout the nanoparticle; and (b) silica distributed throughout the nanoparticle. The surface may be coated with hydroxyl-terminated PEG, which is shown to reduce uptake of the nanoparticles by the liver. The dyes provide for sensitive detection of clinically relevant lesions, and are biodegradable. |
| FILED | Tuesday, July 09, 2019 |
| APPL NO | 17/253959 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/005 (20130101) A61K 49/0093 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268154 | Xie et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingwei Xie (Omaha, Nebraska); Jiang Jiang (Omaha, Nebraska) |
| ABSTRACT | Three dimensional nanofiber structures are provided and methods of production thereof. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317234 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/70 (20130101) A61K 9/0092 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/38 (20130101) A61L 27/56 (20130101) Original (OR) Class A61L 2400/12 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) D01D 10/00 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2331/041 (20130101) D10B 2401/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268156 | HANDA et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY F GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hitesh HANDA (Athens, Georgia); Sean HOPKINS (Athens, Georgia) |
| ABSTRACT | Described herein are nitric oxide releasing materials, methods of making nitric oxide releasing materials, and devices including nitric oxide releasing materials. The nitric oxide releasing material includes a polymer matrix having a plurality of polysiloxanes and nitric oxide-donating crosslinking moieties that covalently crosslink the polysiloxanes. Blood clotting or adhesion of a bio-material to a surface, as well as biofilm formation can be prevented using the methods and materials described. |
| FILED | Tuesday, July 16, 2019 |
| APPL NO | 17/259817 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/10 (20130101) A01N 37/46 (20130101) A01N 43/10 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/48 (20130101) A61L 33/0041 (20130101) Original (OR) Class A61L 33/062 (20130101) A61L 2300/114 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268221 | Gillerman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ian J. Gillerman (Somerville, Massachusetts); Gregory W. Hall (Belmont, Massachusetts); Wolfgang Scholz (Beverly, Massachusetts); David G. Zapol (San Francisco, California) |
| ABSTRACT | Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197911 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/00 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/04 (20130101) A61M 16/12 (20130101) Original (OR) Class A61M 16/022 (20170801) A61M 16/024 (20170801) A61M 16/0057 (20130101) A61M 16/0093 (20140204) A61M 16/101 (20140204) A61M 16/107 (20140204) A61M 16/202 (20140204) A61M 16/0666 (20130101) A61M 2202/0275 (20130101) A61M 2202/0283 (20130101) A61M 2205/05 (20130101) A61M 2205/054 (20130101) A61M 2205/80 (20130101) A61M 2205/125 (20130101) A61M 2205/502 (20130101) A61M 2205/3584 (20130101) A61M 2205/8206 (20130101) A61M 2209/088 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268277 | Chestek et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cynthia Anne Chestek (Ann Arbor, Michigan); Elissa Joy Welle (Ann Arbor, Michigan); John Paul Seymour (Ann Arbor, Michigan); Lauren Leigh Zimmerman (Ann Arbor, Michigan); Zhonghua Ouyang (Ann Arbor, Michigan); Paras Rajni Patel (Ann Arbor, Michigan); Ahmad Jiman (Ann Arbor, Michigan); Timothy Morris Bruns (Ann Arbor, Michigan) |
| ABSTRACT | A carbon fiber implantable probe, a method of manufacturing the carbon implantable probe, and a method of implanting the probe in an implantation site, such as a nerve. The carbon fiber implantable probe includes a flexible probe body, a carbon fiber microarray (CFMA) composing one or more carbon fiber electrodes at least partially embedded in the flexible probe body, and a signal conductor connected to the one or more carbon fiber electrodes of the CFMA. In one example, the CFMA includes carbon fiber electrodes having conductive carbon coms partially surrounded by an insulative coating. The combination of the CFMA with the flexible probe body, made of silicone rubber for example, can improve implantation processes. |
| FILED | Friday, June 21, 2019 |
| APPL NO | 17/254786 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0556 (20130101) A61N 1/36007 (20130101) Original (OR) Class A61N 1/36062 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268315 | GUHA et al. |
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| FUNDED BY |
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| APPLICANT(S) | Montefiore Medical Center (Bronx, New York); Albert Einstein College of Medicine, Inc. (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chandan GUHA (Scarsdale, New York); Stephen BARRY (Haddonfield, New Jersey); Fernando MACIAN (Bronx, New York) |
| ABSTRACT | Systems and methods for treating cancer and for preventing metastasis using low intensity focused ultrasound in combination with an anti-cancer therapy are disclosed. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/191497 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4836 (20130101) A61B 2090/374 (20160201) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) A61N 5/1077 (20130101) A61N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268465 | Di Carlo et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Dino Di Carlo (Los Angeles, California); Joseph de Rutte (Los Angeles, California); Robert Dimatteo (Los Angeles, California) |
| ABSTRACT | Systems and methods are described herein that create discrete volumes associated with solid-phase particles (e.g., drop-carrier particles) suspended in an immiscible phase (e.g., dropicles). One embodiment of the system includes a plurality of hydrogel-based drop-carrier particles containing a microscale voids or cavities that hold an aqueous phase droplet of fluid within each drop-carrier particle. The plurality of hydrogel drop-carrier particles associated with aqueous drops are suspended as individual elements in an immiscible oil phase. The microscale hydrogel drop-carrier particles containing the voids or cavities may be manufactured using microfluidic droplet generators. The dropicles may be used to analyze single-entities (e.g., single-molecules and single-cells) and analytes. |
| FILED | Friday, August 16, 2019 |
| APPL NO | 17/268954 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/003 (20130101) Original (OR) Class B01J 13/0065 (20130101) B01J 13/0069 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 67/0097 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/023 (20130101) C09D 11/037 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268503 | SOPER et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF KANSAS (Lawrence, Kansas); THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina); BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (Baton Rouge, Louisiana); NORTHEASTERN UNIVERSITY (Boston, Massachusetts); CLARKSON UNIVERSITY (Potsdam, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. SOPER (Baton Rouge, Louisiana); Collin J. MCKINNEY (Durham, North Carolina); Elizabeth PODLAHA-MURPHY (Potsdam, New York); Sunggook PARK (Baton Rouge, Louisiana) |
| ABSTRACT | Disclosed are nanofluidic analytical devices. The devices employ a sample processing region that includes a plurality of fluidically connected sample handling elements that, in combination, affect a physical change on a sample introduced into the sample processing region. This physical change can include, for example, purification of an analyte of interest present in the sample, concentration of an analyte of interest present in the sample, chemical modification (e.g., cleavage and/or chemical derivatization) of an analyte of interest present in the sample, or a combination thereof. The analytical devices further include a nanochannel comprising a plurality of in-plane nanopores in series fluidically coupled to the sample processing region. The in-plane nanopores can be used to detect and/or analyze analyte(s) present in the sample following processing by the sample processing region. These analytical devices can advantageously provide for the label-free detection of single molecules. |
| FILED | Monday, July 15, 2019 |
| APPL NO | 17/260125 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0645 (20130101) B01L 2300/0896 (20130101) B01L 2400/0415 (20130101) B01L 2400/0421 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269400 | Silverman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard B. Silverman (Winnetka, Illinois); Ha T. Do (Evanston, Illinois) |
| ABSTRACT | Disclosed are 2-aminopyridine derivative compounds for use as inhibitors of nitric oxide synthase (NOS). In particular, the field of the invention relates to 2-aminopyridine derivative compounds for use as inhibitors of neuronal nitric oxide synthase (nNOS), which are formulated as pharmaceutical compositions for treating diseases and disorders associated with nNOS such as Alzheimer's, Parkinson's, and Huntington's diseases, and amyotrophic lateral sclerosis, cerebral palsy, stroke/ischemic brain damage, and migraine headaches. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184544 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/73 (20130101) Original (OR) Class C07D 401/06 (20130101) C07D 401/10 (20130101) C07D 413/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269418 | Blagg et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Blagg (Notre Dame, Indiana); Sanket Mishra (Notre Dame, Indiana) |
| ABSTRACT | Described are compounds of formula (I), based on an isoquinolin-1(2H)-one backbone, that function as Hsp90β selective inhibitors. Also described are pharmaceutical compositions thereof and methods of treating cancer by administering compounds of formula (I). |
| FILED | Thursday, May 30, 2019 |
| APPL NO | 17/055980 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/04 (20130101) C07D 401/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269431 | LU et al. |
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| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tao LU (Carmel, Indiana); Lakshmi Milind PRABHU (Indianapolis, Indiana) |
| ABSTRACT | Provided are compounds of formulas (I), (II), (III), and (IV), which effectively inhibit protein arginine methyltransferase 5 (PRMT5). Also provided are methods of using the compounds, including a method of treating cancer, a method of inhibiting the activity of PRMT5 in a cell, and a method of treating a disease associated with increased activity of PRMT5. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/320381 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 43/23 (20130101) Heterocyclic Compounds C07D 413/14 (20130101) C07D 453/02 (20130101) Original (OR) Class C07D 487/04 (20130101) C07D 498/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269438 | DAVID et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Sunil A. DAVID (Minneapolis, Minnesota); Yupeng LI (Minneapolis, Minnesota); Michael BRUSH (Minneapolis, Minnesota); Kathryn TRAUTMAN (Minneapolis, Minnesota); Collin GUSTAFSON (Minneapolis, Minnesota); Daniel MAURER (Minneapolis, Minnesota); Balaji PATHAKUMARI (Minneapolis, Minnesota) |
| ABSTRACT | The invention provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3 and R4 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as immunostimulatory agents. |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/256933 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 47/61 (20170801) A61K 47/545 (20170801) A61K 47/6923 (20170801) A61K 2039/55511 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269449 | Plummer et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Plummer (Westbrook, Connecticut); Denton Hoyer (West Haven, Connecticut); Elizabeth Spencer (Southbury, Connecticut) |
| ABSTRACT | In one aspect, the invention provides compounds and methods that are useful for treating bacterial infections: |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/260856 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/427 (20130101) A61K 31/4439 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269453 | Castor |
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| FUNDED BY |
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| APPLICANT(S) | Trevor Percival Castor (Arlington, Massachusetts) |
| ASSIGNEE(S) | Aphios Corporation (Woburn, Massachusetts) |
| INVENTOR(S) | Trevor Percival Castor (Arlington, Massachusetts) |
| ABSTRACT | Embodiments of the present invention feature novel Bryoid compositions, methods of making and methods of treating disease. |
| FILED | Sunday, March 21, 2021 |
| APPL NO | 17/207675 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) Heterocyclic Compounds C07D 493/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269468 | Yarema et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin J. Yarema (Woodstock, Maryland); Christopher T. Saeui (Rockville, Maryland); Alfredo Quinones-Hinojosa (Bel Air, Maryland); Sagar Ramesh Shah (Clemson, South Carolina) |
| ABSTRACT | Disclosed are UAP inhibitors to inhibit glucose flux in the hexosamine biosynthetic pathway and methods of treating a disease using the inhibitors. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127979 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/35 (20130101) A61K 31/7024 (20130101) A61K 45/06 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 13/04 (20130101) Original (OR) Class C07H 13/08 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Enzymes C12Y 207/07023 (20130101) C12Y 207/07083 (20150701) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/9125 (20130101) G01N 2500/04 (20130101) G01N 2500/10 (20130101) G01N 2500/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269487 | Aslanidi et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | George Vladimirovich Aslanidi (Austin, Minnesota); Kim M. Van Vliet (Gainesville, Florida); Mavis Agbandje-McKenna (Gainesville, Florida); Arun Srivastava (Gainesville, Florida) |
| ABSTRACT | Provided herein are modified recombinant adeno-associated virus (rAAV) capsid proteins, such as modified rAAV1, rAAV5, and rAAV6 capsid proteins, rAAV particles comprising such capsid proteins, nucleic acid molecules encoding such capsid proteins, as well as compositions, kits and methods of use thereof. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/174587 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/861 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269488 | Patton |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | The Trustees of Indiana University (Bloomington, Indiana) |
| INVENTOR(S) | John Thomas Patton (Bloomington, Indiana) |
| ABSTRACT | Embodiments herein report compositions, methods, uses and manufacturing procedures for rotavirus constructs and immunogenic compositions thereof. Some embodiments concern compositions that include, but are not limited to, chimeric rotaviruses of use in immunogenic compositions against rotavirus infection as well as against other pathogenic virus infection in a subject. In certain embodiments, constructs of use herein can be generated and used where a rotavirus expression system further includes one or more nucleic acid molecules encoding one or more polypeptides of another pathogen (e.g. another enteric or mucosal pathogen). |
| FILED | Friday, July 12, 2019 |
| APPL NO | 17/259844 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/15 (20130101) A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2720/12321 (20130101) C12N 2720/12322 (20130101) C12N 2720/12334 (20130101) C12N 2720/12351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269490 | Tai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Tai (Ann Arbor, Michigan); David Lin (Ann Arbor, Michigan) |
| ABSTRACT | The disclosure provides materials in the form of flavivirus variants that each encode a Non-Structural Protein-1 (NS1) variant, wherein the coding region is a chimera of at least two different NS1 coding regions, or wherein the coding region has at least one mutation in a codon of a canonical Asn-Xxx-Ser/Thr N-linked glycosylation site, wherein Asn is asparagine, Xxx is any amino acid, and Ser/Thr is either serine or threonine, or wherein the coding region is both a chimera and has at least one mutation in a codon of a canonical N-liked glycosylation site, wherein Asn is asparagine, Xxx is any amino acid, and Ser/Thr is either serine or threonine. The disclosure also provides methods of using such flavivirus variants to inhibit the transmission of infectious flavivirus. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269191 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/1825 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269498 | GARCIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenan Christopher GARCIA (Palo Alto, California); Sonia S. MAJRI (Palo Alto CA, California); Caleb R. GLASSMAN (Palo Alto, California); Leon Lih-Ren SU (Mountain View, California) |
| ABSTRACT | Provided herein, inter alia, are human interleukin-2 (IL-2) muteins or variants thereof. In particular, provided herein are IL-2 muteins that have a decreased binding capacity for IL-2Rγ. Such IL-2 muteins are useful, for example, as IL-2 partial agonist in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of autoimmune diseases or conditions). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/320174 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) Peptides C07K 14/55 (20130101) Original (OR) Class C07K 16/244 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269500 | IRVINE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell J. IRVINE (Arlington, Massachusetts); Yiran ZHENG (Cambridge, Massachusetts); Li TANG (Quincy, Massachusetts) |
| ABSTRACT | The present disclosure is directed, in some embodiments, to methods and compositions of comprising a cell having a non-internalizing receptor, and a nanoparticle surface-modified with a ligand that binds to the non-internalizing receptor. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318590 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 39/0011 (20130101) A61K 39/001104 (20180801) A61K 47/60 (20170801) A61K 47/6849 (20170801) A61K 47/6889 (20170801) A61K 47/6903 (20170801) A61K 47/6913 (20170801) A61K 2039/57 (20130101) A61K 2039/505 (20130101) A61K 2039/585 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) A61K 2039/55527 (20130101) A61K 2039/55533 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/55 (20130101) C07K 14/5443 (20130101) C07K 14/7051 (20130101) Original (OR) Class C07K 14/7155 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 14/70589 (20130101) C07K 16/30 (20130101) C07K 16/289 (20130101) C07K 16/2806 (20130101) C07K 16/2845 (20130101) C07K 19/00 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) C07K 2319/33 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0006 (20130101) C12N 5/0636 (20130101) C12N 5/0638 (20130101) C12N 2501/2315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269526 | OROZCO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington) |
| ASSIGNEE(S) | FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington) |
| INVENTOR(S) | Johnnie J. OROZCO (Seattle, Washington) |
| ABSTRACT | The disclosure is directed to bispecific affinity reagents, e.g., fusion proteins, that specifically bind to CD45 and radioactive ligands. The disclosure also addresses methods of use of the bispecific affinity reagents to specifically target cells with aberrant CD45 expression for therapy. |
| FILED | Tuesday, July 16, 2019 |
| APPL NO | 17/260205 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0482 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 16/44 (20130101) C07K 16/289 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/55 (20130101) C07K 2317/622 (20130101) C07K 2317/626 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269534 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CYTOIMMUNE THERAPEUTICS, INC. (Wilmington, Delaware) |
| ASSIGNEE(S) | CYTOIMMUNE THERAPEUTICS, INC. (Wilmington, Delaware) |
| INVENTOR(S) | Jianhua Yu (Wilmington, Delaware); Michael Caligiuri (Wilmington, Delaware); Steven Devine (Wilmington, Delaware) |
| ABSTRACT | CAR cells targeting FLT3 relevant antigens are described as a new method of cancer treatment. It is proposed that FLT3 CAR cells are safe and effective in patients and can be used to treat human tumors and cancer. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/199332 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/00 (20130101) A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/2863 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6472 (20130101) C12N 2740/16043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269558 | MIYAKE et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado); COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | GARRET MIYAKE (FORT COLLINS, Colorado); JORDAN CORINNE THERIOT (DENVER, Colorado); MATTHEW D. RYAN (LONGMONT, Colorado); RYAN MICHAEL PEARSON (FORT COLLINS, Colorado); TRACY ALLEN FRENCH (FIRCREST, Washington); HAISHEN YANG (SHANGHAI, China PRC); ANDREW LOCKWOOD (Kent, United Kingdom); CHARLES MUSGRAVE (LONGMONT, Colorado); CHERN-HOOI LIM (BOULDER, Colorado); YA DU (SHANGHAI, China PRC); BLAINE MCCARTHY (FORT COLLINS, Colorado) |
| ABSTRACT | The invention provides novel compounds and methods that are useful in promoting reactions that proceed through an oxidative quenching pathway. In certain embodiments, the reactions comprise atom transfer radical polymerization. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/190110 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/0244 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 37/02 (20130101) C07B 39/00 (20130101) C07B 41/00 (20130101) C07B 43/00 (20130101) C07B 45/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/48 (20130101) C08F 2/50 (20130101) Original (OR) Class C08F 4/40 (20130101) C08F 20/14 (20130101) C08F 220/14 (20130101) C08F 220/18 (20130101) C08F 220/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269601 | Luo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juntao Luo (Syracuse, New York); Xu Wang (Syracuse, New York); Changying Shi (Jamesville, New York) |
| ABSTRACT | Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/189868 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/107 (20130101) A61K 9/5146 (20130101) A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/329 (20130101) C08G 83/00 (20130101) C08G 83/002 (20130101) Original (OR) Class C08G 2650/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269782 | Doudna et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); David Frank Savage (Berkeley, California); Sean A. Higgins (Berkeley, California); Benjamin L. Oakes (Berkeley, California) |
| ABSTRACT | The present disclosure provides an RNA-guided effector polypeptide having a length that is less than Streptococcus pyogenes Cas9, and that retains the ability, when complexed with a guide RNA, to bind to a target nucleic acid. The present disclosure provides a fusion polypeptide comprising: i) an RNA-guided effector polypeptide of the present disclosure; and ii) a fusion partner. The present disclosure further provides nucleic acids encoding an RNA-guided effector polypeptide, or a fusion polypeptide, of the present disclosure. Methods of using an RNA-guided effector polypeptide, or a fusion polypeptide, of the present disclosure are also provided. |
| FILED | Tuesday, June 25, 2019 |
| APPL NO | 17/057531 |
| CURRENT CPC | Peptides C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269786 | Kaznessis et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yiannis John Kaznessis (New Brighton, Minnesota); Seth Ritter (Minneapolis, Minnesota); Benjamin Hackel (Edina, Minnesota) |
| ABSTRACT | Provided herein are a vector, a genetically modified bacterium including the vector, methods of making the bacterium, methods of using the bacterium, and kits including the bacterium. The vector includes a coding region encoding at least one antimicrobial peptide, and the antimicrobial peptide includes at least one lysin. |
| FILED | Friday, September 07, 2018 |
| APPL NO | 16/645281 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/747 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/2462 (20130101) Original (OR) Class C12N 15/746 (20130101) Enzymes C12Y 302/01017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269788 | Joung et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Benjamin Kleinstiver (Medford, Massachusetts); Alexander Sousa (Boston, Massachusetts) |
| ABSTRACT | Engineered CRISPR from Prevotella and Francisella 1 (Cpf1) nucleases with improved targeting range and enhanced on-target activity, and their use in genomic engineering, epigenomic engineering, base editing, genome targeting, genome editing, and in vitro diagnostics. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244738 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/52 (20130101) C12N 9/88 (20130101) Original (OR) Class C12N 15/62 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6813 (20130101) Enzymes C12Y 401/99013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269794 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sidi Chen (Milford, Connecticut); Ryan D. Chow (San Jose, California); Lupeng Ye (New Haven, Connecticut); Matthew Dong (San Francisco, California); Jonathan Park (Scott AFB, Illinois); Lei Peng (New Haven, Connecticut) |
| ABSTRACT | The present invention includes dead-guide RNA (dgRNA) libraries and methods of use in immunology and immunotherapy thereof. Also provided are engineered primary or chimeric antigen receptor (CAR) T cells that overexpress Prodh2, Ccnblip1, Sreklip1, or Wdr37or a fragment thereof, and methods of use in immunology and immunothereapy thereof. |
| FILED | Thursday, August 15, 2019 |
| APPL NO | 17/268928 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/907 (20130101) C12N 15/1082 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269798 | ROSSI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | CITY OF HOPE (Duarte, California) |
| INVENTOR(S) | John J. ROSSI (Duarte, California); Minsun SONG (Duarte, California) |
| ABSTRACT | Provided are methods for improving stability of small therapeutic RNAs by adding one or more non-templated nucleotides such as cytidines and uridines to the 3′ end of the small therapeutic RNAs. Also disclosed are modified small therapeutic RNAs comprising one or more non-templated nucleotides such as cytidines and uridines at the 3′ end and pharmaceutical compositions comprising such modified small therapeutic RNAs. |
| FILED | Thursday, June 27, 2019 |
| APPL NO | 17/253299 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/141 (20130101) C12N 2320/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269801 | Weiss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Weiss (Decatur, Georgia); Hannah Ratner (Corvallis, Oregon) |
| ABSTRACT | This disclosure relates to methods of using a guide RNA sequence and CRISPR associated (Cas) nucleases for the purpose of managing replication of nucleic acids or expression of genes associated therewith. In certain embodiments, methods further optionally contemplate cleaving the nucleic acids at desired target sequences. Although it is not intended that certain embodiments of this disclosure be limited by any particular mechanism, is believed that shortening a guide sequence to partially hybridize with a target template strand prevents a guide RNA and Cas nuclease complex from catalyzing the cleavage of the nucleic acids and represses RNA transcription or protein expression. |
| FILED | Wednesday, August 14, 2019 |
| APPL NO | 17/268592 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/74 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269803 | Kortylewski et al. |
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| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcin Kortylewski (Monrovia, California); Piotr Marek Swiderski (San Dimas, California); Steven Rosen (Duarte, California) |
| ABSTRACT | Disclosed herein, inter alia, are oligonucleotide-based proteolysis targeting chimeras and methods of use thereof. |
| FILED | Monday, June 17, 2019 |
| APPL NO | 17/251549 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/545 (20170801) A61K 47/549 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/117 (20130101) Original (OR) Class C12N 2310/13 (20130101) C12N 2310/14 (20130101) C12N 2310/17 (20130101) C12N 2310/315 (20130101) C12N 2310/351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269805 | Young et al. |
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| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A. Young (Boston, Massachusetts); Alla A. Sigova (Newton, Massachusetts); Brian J. Abraham (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are methods useful for modulating expression of a target gene by modulating binding between a ribonucleic acid (RNA) transcribed from at least one regulatory element of a target gene and a transcription factor which binds to both the RNA and the regulatory element. Also disclosed herein are methods and assays for identifying agents that interfere with binding between RNA transcribed from at least one regulatory element and a transcription factor which binds to the RNA and to the regulatory element. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217612 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/1051 (20130101) C12N 15/1135 (20130101) Original (OR) Class C12N 2310/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269825 | Chamberlain |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Joel Chamberlain (Seattle, Washington) |
| ABSTRACT | The disclosure features compositions and methods for the treatment of disorders associated with improper ribonucleic acid (RNA) splicing, including disorders characterized by nuclear retention of RNA transcripts containing aberrantly expanded repeat regions that bind and sequester splicing factor proteins. Disclosed herein are interfering RNA constructs that suppress the expression of RNA transcripts containing expanded repeat regions, as well as viral vectors, such as adeno-associated viral vectors, encoding such interfering RNA molecules. For example, the disclosure features interfering RNA molecules, such as siRNA, miRNA, and shRNA constructs, that anneal to dystrophia myotonica protein kinase (DMPK) RNA transcripts and attenuate the expression of DMPK RNA containing expanded CUG trinucleotide repeats. Using the compositions and methods described herein, a patient having an RNA dominance disorder, such as a human patient having myotonic dystrophy, among other conditions described herein, may be administered an interfering RNA construct or vector containing the same so as to reduce the occurrence of spliceopathy in the patient, thereby treating an underlying etiology of the disease. |
| FILED | Wednesday, May 15, 2019 |
| APPL NO | 17/054474 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2310/122 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) C12N 2320/32 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) Enzymes C12Y 207/11001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269827 | Wei et al. |
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| FUNDED BY |
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| APPLICANT(S) | GenVec, Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | GenVec, Inc. (Gaithersburg, Maryland) |
| INVENTOR(S) | Lisa Wei (Gaithersburg, Maryland); Douglas E. Brough (Gaithersburg, Maryland); C. Richter King (New York, New York) |
| ABSTRACT | The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200012 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) A61K 48/0008 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2710/10021 (20130101) C12N 2710/10043 (20130101) C12N 2710/10322 (20130101) C12N 2710/10343 (20130101) C12N 2710/10345 (20130101) C12N 2710/16634 (20130101) C12N 2810/6018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269831 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng ZHANG (Cambridge, Massachusetts); Randall Jeffrey PLATT (Cambridge, Massachusetts); Guoping FENG (Cambridge, Massachusetts); Yang ZHOU (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for delivery, engineering and optimization of systems, methods and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245952 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 67/0278 (20130101) A01K 2217/05 (20130101) A01K 2217/07 (20130101) A01K 2217/052 (20130101) A01K 2217/072 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/01 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 15/86 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/8213 (20130101) C12N 15/8509 (20130101) C12N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269839 | Nair et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikhil U. Nair (Medford, Massachusetts); Josef R. Bober (Medford, Massachusetts) |
| ABSTRACT | Disclosed are components and methods for preparing tagatose from galactose via isomerization reactions using engineered components. The engineered components include microbial cells and methods for preparing microbial cells that have been engineered to catalyze isomerization of galactose to tagatose, in which the microbial cells express cytoplasmically an exogenous L-arabinose isomerase enzyme. The disclosed microbial cells may further be modified for use in methods for preparing tagatose from galactose via isomerization reactions where the microbial cells are treated with reagents that permeabilize the cells. The disclosed methods enable isomerization reactions of galactose to tagatose at relatively high rates, high conversions, and elevated temperatures. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168499 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/90 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269841 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (COLLEGE PARK, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LAI-XI WANG (ELLICOTT CITY, Maryland); QIANG YANG (ELLICOTT CITY, Maryland); TIEZHENG LI (COLUMBIA, Maryland); XIN TONG (COLLEGE PARK, Maryland) |
| ABSTRACT | The present invention provides for recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/320703 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/549 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/32 (20130101) C07K 16/2887 (20130101) C07K 2317/41 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Original (OR) Class Enzymes C12Y 302/01096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269858 | Chiu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles Chiu (San Francisco, California); Andrea Granados (San Francisco, California); Jennifer A. Doudna (Berkeley, California); Lucas B. Harrington (Berkeley, California); Janice S. Chen (Berkeley, California); Xianding Deng (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods for characterizing a target DNA present in a sample. The methods involve contacting the sample with a type V CRISPR/Cas effector protein and one or more guide RNAs, where the contacting generates a cleavage product comprising a 5′ overhang; and ligating a double-stranded nucleic acid adapter to the cleavage product, to generate a ligation product. The ligation product includes the target DNA, which can be sequenced. The sample can be subjected to one or more amplification steps prior to the contacting step, with primers that provide for amplification of nucleic acids of, e.g., specific pathogens, categories of pathogens, two or more different pathogens, or two or more different categories of pathogens. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319907 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/701 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6888 (20130101) C12Q 1/6893 (20130101) C12Q 1/6895 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269865 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chao-ting Wu (Brookline, Massachusetts); Son Nguyen (West Roxbury, Massachusetts) |
| ABSTRACT | The present invention relates to a method of covalently attaching a chromosome within a cell to a matrix including modifying a plurality of nucleotides within the chromosome to include a matrix attachment moiety wherein the chromosome contacts the matrix, and attaching the matrix attachment moiety of the plurality of nucleotides to the matrix, thereby attaching the chromosome to the matrix. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/241146 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6841 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269866 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Max Kellner (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Omar Abudayyeh (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are methods and systems for amplifying and/or detecting target double-stranded or single-stranded nucleic acids. The methods comprise combining a sample comprising the target nucleic acid with an amplification reaction mixture, amplifying the target nucleic acid, and further amplifying the target nucleic acid by repeated opening, unwinding, annealing and extension under isothermal conditions. The amplification reaction mixture may include an amplification CRISPR system, a helicase, a primer pair, and a polymerase. The amplification CRISPR system may comprise a first and second CRISPR/Cas complex, the first and second CRISPR/Cas complex may comprise a first CRISPR/Cas enzyme and a first guide molecule that guides the first CRISPR/Cas complex to a first strand of the target nucleic acid; the second CRISPR/Cas complex may comprise a second CRISPR/Cas enzyme and a second guide molecule that guides the second CRISPR/Cas complex to a second strand of the target nucleic acid. |
| FILED | Wednesday, June 26, 2019 |
| APPL NO | 16/973061 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269869 | Lindsay |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (SCOTTSDALE, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart Lindsay (SCOTTSDALE, Arizona) |
| ABSTRACT | The present disclosure provides devices, systems, and methods related to sequencing a biopolymer. In particular, the present disclosure provides methods of obtaining a bioelectronic signature based on current fluctuations that correspond to the activity of an enzyme-of-interest. As described herein, certain aspects of the bioelectronic signature can be used to determine the sequence of a biopolymer. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184201 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) C12Q 1/6869 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/125 (20130101) G01N 33/48721 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/20 (20190201) G16B 40/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269877 | BOYANOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Illumina, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BOYAN BOYANOV (San Diego, California); JEFFREY G MANDELL (San Diego, California); KEVIN L GUNDERSON (San Diego, California); JINGWEI BAI (San Diego, California); LIANGLIANG QIANG (San Diego, California); BRADLEY BAAS (Madison, Wisconsin) |
| ABSTRACT | The disclosure provides detection apparatus having one or more nanopores, methods for making apparatus having one or more nanopore and methods for using apparatus having one or more nanopores. Uses include, but are not limited to detection and sequencing of nucleic acids. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188193 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6874 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44782 (20130101) G01N 27/44791 (20130101) G01N 33/48721 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269886 | MINN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andy J. MINN (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention includes methods for treating cancer and selecting a patient for immunotherapy administration. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/274426 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270595 | So et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Peter T. C. So (Boston, Massachusetts); Zahid Yaqoob (Cambridge, Massachusetts); Dominika Lyzwa (Boston, Massachusetts); Vijay Singh (Arlington, Massachusetts); Dushan N. Wadduwage (Cambridge, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter T. C. So (Boston, Massachusetts); Zahid Yaqoob (Cambridge, Massachusetts); Dominika Lyzwa (Boston, Massachusetts); Vijay Singh (Arlington, Massachusetts); Dushan N. Wadduwage (Cambridge, None) |
| ABSTRACT | Our high phase sensitivity wide-field phase cancellation interferometry system allows single-shot, label-free optical sensing of neural action potentials via imaging of optical path length changes. Single-shot sensing and monitoring of single neurons within a neural network should lead to a more comprehensive understanding neural network processing, which is beneficial for the advancement in the field of neuroscience as well as its biomedical applications and impact. Our system cancels the phase profile of the resting neuron from the phase profile of the spiking neuron, improving the sensitivity by two orders of magnitude. Using a detector with an extremely large well depth and an appropriately biased interferometer increases the sensitivity by another order of magnitude, yielding a measurement that is three orders of magnitude more sensitive than those possible with other microscopes. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140558 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02057 (20130101) Original (OR) Class G01B 9/02067 (20130101) G01B 9/02081 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0056 (20130101) G02B 21/361 (20130101) Computer Systems Based on Specific Computational Models G06N 3/0675 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270716 | Vacca et al. |
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| FUNDED BY |
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| APPLICANT(S) | Kinetic River Corp. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giacomo Vacca (Campbell, California); Ralph Jimenez (Boulder, Colorado) |
| ABSTRACT | Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307975 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) Original (OR) Class G01N 15/147 (20130101) G01N 15/1429 (20130101) G01N 15/1434 (20130101) G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270720 | Vacca et al. |
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| FUNDED BY |
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| APPLICANT(S) | Kinetic River Corp. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giacomo Vacca (Campbell, California); Ralph Jimenez (Boulder, Colorado) |
| ABSTRACT | Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308941 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1436 (20130101) Original (OR) Class G01N 2015/144 (20130101) G01N 2015/1438 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270807 | LAKE et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (SCOTTSDALE, Arizona); MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas LAKE (Scottsdale, Arizona); Thai H. HO (Scottsdale, Arizona); Glen J. WEISS (Phoenix, Arizona) |
| ABSTRACT | The present invention includes a method for screening one or more agents that modulate Regulatory T cell (Treg) activity, the method comprising the steps of: incubating a population CD4+ cells isolated from human blood peripheral mononuclear cells the CD4+ cells in contact with MoT cells in the presence of the one or more agents suspected of modulating Treg activity; detecting activation of the CD4+ cells without or with the agent; and comparing the activation of the CD4+ cells without or with the agent, wherein a change in activation following incubation with the agent relative to the activation of the PBMCs following incubation without the agent indicates that the agent is a modulator of Treg activity. |
| FILED | Wednesday, September 25, 2019 |
| APPL NO | 17/256592 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270831 | Guo et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge,, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junling Guo (Roxbury Crossing, Massachusetts); Miguel Suastegui (Boston, Massachusetts); Neel Saitish Joshi (Somerville, Massachusetts) |
| ABSTRACT | Modular biohybrid systems, some of which suitable for photochemical biosynthesis, are described. These systems are characterized by functionalized photocatalytic nanoparticles that are independently prepared, then assembled and attached to the modified surface of a cell, thereby enabling the cell to absorb light energy and convert it into chemical energy, for example in the form of a redox cofactor. The generated chemical energy then serves as fuel for production pathways of metabolites useful for the manufacturing of fuels, nutraceuticals, pharmaceuticals and cosmetics. |
| FILED | Tuesday, June 25, 2019 |
| APPL NO | 17/255757 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/554 (20130101) Original (OR) Class G01N 33/54346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270841 | Kellum et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Kellum (Pittsburgh, Pennsylvania); Zhiyun Cao (Chicago, Illinois); Derek Angus (Pittsburgh, Pennsylvania); Sachin Purushottam Yende (Pittsburgh, Pennsylvania); Rena Angilena Sowell Robinson (Pittsburgh, Pennsylvania) |
| ABSTRACT | A proteomic expression platform to identify age-related sepsis risk is disclosed using patients with an intra-abdominal infection. A semi-quantitative plasma proteomics workflow was applied which incorporated tandem immuno affinity depletion, iTRAQ labeling, strong cation exchange fractionation, and nanoflow-liquid chromatography coupled to high resolution mass spectrometry. A protein profile was determined that exhibit statistically significant differences in expression levels amongst patients with severe sepsis as a function of age. Representative pathways that are differentially-expressed include, but are not limited to, acute phase response, coagulation signaling, atherosclerosis signaling, lipid metabolism, and production of nitric oxide/reactive oxygen species. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/177612 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) Original (OR) Class G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270847 | WANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Ka-Wang WANG (Gainesville, Florida); George Anis SARKIS (Lexington, Massachusetts); Manasi KAMAT (Gainesville, Florida); Hamad YADIKAR (Gainesville, Florida); Ahmed MOGHIEB (Royersford, Pennsylvania) |
| ABSTRACT | The invention relies on detection of specific identified proteins, protein breakdown products, and peptide fragments, to diagnose and evaluate traumatic brain injury, spinal cord injury, and any traumatic injury to the CNS in a subject. These analytes (proteins, protein breakdown products thereof, and peptide fragments thereof) are released from injured tissue into blood and/or cerebrospinal fluid, and can be used to identify the central nervous system cell types (i.e. neuron, astrocyte, oligodendrocyte, and the like) or subcellular structure (e.g., axon, dendrites, presynaptic terminal, post-synaptic terminal, and extracellular matrix) affected, and to determine the diagnosis, location, and severity of the injury. Time course measurements of these analytes measured at different times after an injury or suspected injury also are used as tools for diagnosis and prognosis of central nervous system injury. Proteins, protein breakdown products, and peptide fragments are claimed, as well as kits and methods for their use. |
| FILED | Monday, August 19, 2019 |
| APPL NO | 17/269041 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2496/00 (20130101) G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270851 | Parker |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karen J. Parker (Stanford, California) |
| ABSTRACT | The application is about a method for diagnosing autism spectrum disorder (ASD) in a human subject, comprising providing a device comprising a reagent for determining the concentration of arginine vasopressin (AVP) in a biological sample from the subject; and measuring the concentration of AVP in the sample using the device. Disclosed is also a method for diagnosing ASD, comprising providing a first device comprising a reagent for determining a concentration of AVP and a second device comprising a reagent for determining a concentration of one or more analytes selected from arginine vasopressin receptor 1a and oxytocin receptor, to determine the concentrations of AVP and of the one or more analytes. Disclosed is also a method of predicting severity of ASD in a male human subject, comprising providing a device for determining the concentration of AVP in cerebrospinal fluid, said device comprising a reagent for determining presence or absence of AVP; and measuring the concentration of AVP in a biological sample from the subject using the device. Disclosed is also a method of predicting likelihood of an ASD in a human subject, comprising providing a device for determining the concentration of AVP in cerebrospinal fluid, said device comprising a reagent for determining presence or absence of AVP; and measuring the concentration of AVP in cerebrospinal fluid using the device. |
| FILED | Thursday, February 21, 2019 |
| APPL NO | 16/975114 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) Original (OR) Class G01N 33/566 (20130101) G01N 2333/575 (20130101) G01N 2496/00 (20130101) G01N 2800/38 (20130101) G01N 2800/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270852 | Finno et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carrie Finno (Davis, California); Birgit Puschner (Davis, California) |
| ABSTRACT | Methods of detecting neuroaxonal dystrophy associated with vitamin E deficiency in a non-human subject are provided. Methods of detecting an equine neuroaxonal dystrophy (eNAD)/equine degenerative myeloencephalopathy (EDM) (eNAD/EDM) disorder in an equine subject, including the presence or the absence of such a disorder, are provided. The subject methods may involve identifying an elevated rate of alpha-tocopherol metabolism in the subject. Methods of treating non-human subjects for neuroaxonal associated with vitamin E deficiency, including eNAD/EDM disorders, are provided as well. Also provided are methods of screening a non-human subject for breeding and/or breeding such non-human subjects, wherein the methods involve detecting the presence or absence of a neuroaxonal dystrophy associated with vitamin E deficiency, including an eNAD/EDM disorder, in the subject. Kits, reagents and/or devices for use in performing the herein described methods are also provided. |
| FILED | Wednesday, June 12, 2019 |
| APPL NO | 16/972495 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/82 (20130101) Original (OR) Class G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270855 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan D. Smith (Shaker Heights, Ohio); Kailash Gulshan (Mayfield Heights, Ohio); Stanley L. Hazen (Pepper Pike, Ohio) |
| ABSTRACT | Provided herein are compositions, systems, kits, and methods for detecting cardiovascular disease, risk of cardiovascular disease, and/or reverse cholesterol transport potential in a subject based on the levels of PIP2 phospholipid in the subject. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/203883 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 16/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 15/1138 (20130101) Enzymes C12Y 301/03078 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 33/6893 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270921 | Basser |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The U.S.A, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Peter J. Basser (Washington, District of Columbia) |
| ABSTRACT | Magnetic resonance methods comprise tractographically establishing a path along a structure in a specimen and finding a distribution of structure radii or cross-sectional areas along the path. Based on the distribution and the path, end-to-end functional characteristics of the structure are estimated. For example, nerve transit times or distributions of transit times can be estimated for a plurality of nervous system locations such as Brodmann areas. Comparison of estimated transit times or distributions thereof between reference values or other values from the same structure can be used to assess specimen health. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306841 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/40 (20130101) A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/5608 (20130101) Original (OR) Class G01R 33/56341 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210271060 | Shroff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | c/o THE UNITED STATES OF AMERICA, AS REPRSENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SER (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hari Shroff (Bethesda, Maryland); John Paul Giannini (Bethesda, Maryland); Yicong Wu (Bethesda, Maryland); Patrick Jean La Riviere (Bethesda, Maryland); Min Guo (Bethesda, Maryland); Jiji Chen (Bethesda, Maryland); Harshad Vishwasrao (Bethesda, Maryland); Xuesong Li (Rockville, Maryland) |
| ABSTRACT | Various embodiments for systems and methods for improved axial resolution in a microscopy using photoswitching and standing-wave illumination techniques are described. |
| FILED | Thursday, June 27, 2019 |
| APPL NO | 17/253090 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 33/582 (20130101) G01N 2021/6439 (20130101) G01N 2021/6478 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) Original (OR) Class G02B 21/0048 (20130101) G02B 21/0076 (20130101) G02B 21/367 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272339 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bae-Hyung Kim (London, United Kingdom); Azra Alizad (Rochester, Minnesota); Mostafa Fatemi (Rochester, Minnesota); Viksit Kumar (Rochester, Minnesota) |
| ABSTRACT | Systems and methods for reconstructing, estimating, or otherwise generating unacquired, undetected, unreconstructed, or otherwise unknown ultrasound data using machine learning algorithms are provided. Thus, the systems and methods described in the present disclosure provide for generating unacquired, undetected, unreconstructed, or otherwise unknown data that are not actually and physically acquired with an ultrasound transducer and/or front-end receiver of an ultrasound system. |
| FILED | Monday, July 08, 2019 |
| APPL NO | 17/257936 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/4245 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 11/008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272661 | Rotroff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel M. Rotroff (Pepper Pike, Ohio); Kevin M. Pantalone (Stow, Ohio); Galen Miller-Atkins (Cleveland, Ohio); Arshiya Mariam (Grafton, Ohio) |
| ABSTRACT | Systems and methods are provided for assigning a treatment to a patient is provided. A set of genetic data representing a patient. A polygenic score representing the likelihood that a patient will benefit from intensive glycemia treatment is generated from the set of genetic data. A parameter representing a response of the patient to intensive glycemia treatment is assigned according to the polygenic score |
| FILED | Saturday, February 27, 2021 |
| APPL NO | 17/187782 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 50/30 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) Original (OR) Class G16H 10/60 (20180101) G16H 15/00 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272664 | Carter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Calvin S. Carter (Iowa City, Iowa); Sunny C. Huang (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Calvin S. Carter (Iowa City, Iowa); Sunny C. Huang (Iowa City, Iowa) |
| ABSTRACT | A system for use with a magnetic non-parallel electric field (MNPEF) or magnetic non-parallel magnetic field (MNPMF) therapy may comprise a processor-based system including at least one processor and memory comprising instructions. When executed by the processor-based system, the instructions cause the processor-based system to: access metrics of a subject who is being treated with the MNPEF or MNPMF therapy, wherein the accessed metrics include at least one analyte, the at least one analyte including one or more of blood glucose data, lactate data, or pyruvate data, free fatty acid data, cholesterol data, and compliance data for complying with an MNPEF or MNPMF therapy; use the accessed metrics as an input to a machine learning algorithm that is configured to determine a set of therapy parameters for the MNPEF or MNPMF therapy, and program the MNPEF or MNPMF therapy using the determined set of therapy parameters. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307830 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14532 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/004 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/00 (20180101) Original (OR) Class G16H 80/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272694 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Sacheth Chandramouli (Chicago, Illinois); Patrick Leo (Honeoye Falls, New York); Andrew Janowczyk (East Meadow, New York) |
| ABSTRACT | Embodiments discussed herein facilitate determination of a likelihood of biochemical recurrence (BCR) of cancer (e.g., prostate cancer, etc.). One example embodiment is a method, comprising: accessing at least a portion of a digitized stained histology slide comprising a tumor; automatically segmenting, via a trained deep learning (DL) model, cribriform morphology in connection with the tumor on the at least the portion of the digitized stained histology slide; determining a cribriform-to-tumor area ratio (CAR) based at least in part on an area of the segmented cribriform morphology and an area of the tumor; and determining a risk of biochemical recurrence (BCR) of a cancer associated with the tumor based at least in part on the CAR. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140544 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30096 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/20 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/70 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272696 | DeMazumder |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University Of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deeptankar DeMazumder (Baltimore, Maryland) |
| ABSTRACT | One or more time-varying signals from continuous monitoring of an individual or the individual's environment are processed in a non-linear fashion to develop signatures for those signals to assess the individual's health. Qualitative data such as individual, family, and/or health care provider reporting of activity or status, and lab data, may also be used. The system may compute an integrated likelihood of the individual experiencing an illness or condition, which is provided to the individual and/or a training or health-care provider for the individual, and updated on a time schedule, giving pre-symptomatic notice of illnesses and early identification of conditions. The system may also optimize a course of performance training and diet. Further, by incorporating treatment data, the invention may be used in forming a quality measure of the individual's care, health, function, risk of adverse or undesired event, and efficacy or lack thereof of medical treatments or other necessary interventions. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 16/806786 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4812 (20130101) A61B 5/7235 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210272697 — Brain and Psychological Determinants of Placebo Response in Patients with Chronic Pain
| US 20210272697 | Apkarian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | A. Vania Apkarian (Chicago, Illinois); Etienne Vachon-Presseau (Montreal, Canada); Sara Berger (Evanston, Illinois); Thomas J. Schnitzer (Chicago, Illinois) |
| ABSTRACT | Methods are disclosed for determining brain and psychological determinants of placebo response in individuals. The method may include creating a biosignature for use as a predictor of placebo response by neuroimaging a brain of an individual with magnetic resonance imaging, identifying a prefrontal cortex functional connection, identifying capacity of awareness and regulation of emotions, and stratifying the individual as a predicted placebo responder or a non-responder based upon the prefrontal cortex functional connection, capacity of awareness, and regulation of emotions. Methods are also disclosed for treating a patient with chronic pain using a biosignature to predict placebo response and wherein the treatment is inert. |
| FILED | Monday, July 08, 2019 |
| APPL NO | 17/255911 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 30/40 (20180101) G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272699 | Berson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert E. Berson (Louisville, Kentucky); Javad Hashemi (Louisville, Kentucky); Shahab Ghafghazi (Louisville, Kentucky) |
| ABSTRACT | A non-invasive computer-based method and system for assessing a coronary stenosis or other blockage in an artery or other vasculature includes creating a computational model of the vasculature of interest, modeling blood flow through the vasculature, and determining the mean residence time through a given coronary artery segment, which is a direct assessment of physiological changes on the flow of blood as a result of the stenosis. In some embodiments, blood is modeled as a multi-phase fluid. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/261227 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/029 (20130101) A61B 5/7246 (20130101) A61B 2560/02 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 17/00 (20130101) G06T 2207/10028 (20130101) G06T 2207/30104 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) G16H 50/50 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272729 | Mine et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susumu Mine (Niskayuna, New York); Minfeng Xu (Ballston Lake, New York); Anbo Wu (Clifton Park, New York); Paul St. Mark Shadforth Thompson (Stephentown, New York) |
| ABSTRACT | A current lead assembly for minimizing heat load to a conduction cooled superconducting magnet during a ramp operation is provided. The current lead assembly includes a vacuum chamber having a through hole to enable a first end of a current lead contact to remain outside the vacuum chamber and a second end of the current lead contact to penetrate within the vacuum chamber. A vacuum boundary wall is located between the vacuum chamber and the current lead contact. At least one superconducting magnet is arranged inside of the vacuum chamber and includes a magnet lead. A second end of the current lead contact is coupled to the magnet lead via an internal lead. A vacuum cap is removably disposed to sealingly encompass therein the first end of the current lead contact during a first state of operation. The first end of the current lead contact is arranged to contact a power supply during a second state of operation, wherein the contact occurs exterior the vacuum chamber. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 16/804645 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/04 (20130101) H01F 6/008 (20130101) Original (OR) Class Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 4/68 (20130101) Installation of Electric Cables or Lines, or of Combined Optical and Electric Cables or Lines H02G 15/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210267487 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zhaoran Huang (Clifton Park, New York); Alex Hollingsworth (Syracuse, New York); Clare Thiem (Clinton, New York); Nathan McDonald (Ava, New York); Zhizhuo Liang (Troy, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Zhaoran Huang (Clifton Park, New York); Alex Hollingsworth (Syracuse, New York); Clare Thiem (Clinton, New York); Nathan McDonald (Ava, New York); Zhizhuo Liang (Troy, New York) |
| ABSTRACT | In an embodiment, there is provided a method of predicting respiratory motion in real-time. The method includes training, by a training module, a recurrent neural network circuitry in real time. The training is performed over a training time interval. The training is based, at least in part, on a training data set. The training data set includes a training number of measured position samples. The measured position samples are related to respiratory motion of a patient target region. The method further includes predicting, by the trained recurrent neural network circuitry, a future position of the patient target region at a future point in time based, at least in part, on a prediction data set. The future point in time is a look ahead time interval in the future relative to a prediction time interval. The prediction data set includes a prediction number of measured position samples. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188312 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/113 (20130101) Original (OR) Class A61B 5/7267 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0445 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/00 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267574 | SHEPARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (, None) |
| INVENTOR(S) | KENNETH SHEPARD (Ossining, New York); JEFFREY ELLOIAN (New York, New York); TIAGO COSTA (New York, New York) |
| ABSTRACT | An exemplary ultrasound (US) apparatus, can include, for example, a flexible substrate, a plurality of ultrasound transducers coupled to the flexible substrate, and an integrated circuit(s) (IC(s)) mounted on the substrate to drive and control the transducer array, where the IC(s) can be configured to control an excitation phase of the ultrasound transducers based at least in part on a shape of the flexible substrate. The ultrasound transducers can be an array of bulk piezoelectric transducers. The substrate can be a flexible printed circuit board. The IC(s) can be configured to separately control (i) a transmission of ultrasound energy from each of the transducers, (ii) a magnitude, or a (iii) phase, where the IC(s) can be configured to use the phase to focus the transmitted energy compensating for a curvature of the ultrasound apparatus. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 16/901289 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/085 (20130101) A61B 8/4236 (20130101) A61B 8/4494 (20130101) Original (OR) Class A61B 2562/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267826 | Cooper et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Govemment as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rory Alan Cooper (Gibsonia, Pennsylvania); Chengshiu Chung (Pittsburgh, Pennsylvania); Garrett G. Grindle (Pittsburgh, Pennsylvania); Rosemarie Cooper (Gibsonia, Pennsylvania); Sathish Andrea Sundaram (Pittsburgh, Pennsylvania) |
| ABSTRACT | A wheelchair system includes a wheelchair including a plurality of force sensors including at least three force sensors. A rigid seat pan is placed in contact with each the plurality of force sensors at a different position on the rigid seat pan so that the rigid seat pan does not contact the frame and forces on the rigid seat pan are transferred to the plurality of force sensors. Each of the plurality of force sensors is in communicative connection with a processor system. A memory system is in communicative connection and an interface system is in connection with the processor system and a user interface system in communicative connection with the processor system. Instructions stored on the memory system are executable by the processor system to determine a value of a variable related to a distribution of force on the rigid seat pan over time. |
| FILED | Thursday, July 11, 2019 |
| APPL NO | 17/259173 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/128 (20161101) A61G 5/1043 (20130101) A61G 5/1091 (20161101) Original (OR) Class A61G 2203/32 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 40/63 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267962 | Dow et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | 60 Degrees Pharmaceuticals LLC (Washington, District of Columbia) |
| ASSIGNEE(S) | 60 Degrees Pharmaceuticals LLC (Washington, District of Columbia); THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY (FORT DETRICK, Maryland) |
| INVENTOR(S) | Geoffrey S. Dow (Washington, District of Columbia); Bryan L. Smith (Chevy Chase, Maryland); John P. Jones (Richmond, Virginia); Moshe Shmuklarsky (Bethesda, Maryland); Budda Balasubrahmanyam (Richmond, Virginia) |
| ABSTRACT | Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I). A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects. The methods of the invention further pertain to using the described algorithm to derive dosing regimens which can provide protection against symptomatic malaria in malaria-naïve, G6PD-normal subjects. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/145530 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4706 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) Heterocyclic Compounds C07D 215/40 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268020 | ERUSLANOV et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evgeniy ERUSLANOV (Havertown, Pennsylvania); Steven Albelda (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods that provide novel anti-tumor therapies in cancer. In one aspect, the present invention features a hybrid neutrophil in a non-naturally occurring container, wherein the hybrid neutrophil expresses at least one neutrophil associated molecule selected from the group consisting of: Arg1, MPO, CD66b, and CD15, and at least one antigen-presenting cell (APC) associated molecule selected from the group consisting of: CD14, HLA-DR, CD32, CD64, and CD89. In another aspect, the present invention features methods of generating a hybrid neutrophil. In still another aspect, the present invention features methods of inhibiting tumor growth in a subject, treating a tumor in a subject, and increasing efficacy of an antibody against a tumor in a subject. The methods comprise (a) administering to the subject an effective amount of an anti-tumor antibody and (b) administering to or generating in the subject an effective amount of a hybrid neutrophil. |
| FILED | Tuesday, December 15, 2020 |
| APPL NO | 17/122521 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 35/15 (20130101) Original (OR) Class A61K 38/193 (20130101) A61K 38/217 (20130101) A61K 39/0011 (20130101) A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2039/572 (20130101) A61K 2039/585 (20130101) A61K 2039/5158 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0642 (20130101) C12N 2501/22 (20130101) C12N 2501/24 (20130101) C12N 2501/599 (20130101) C12N 2502/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268274 | PAKHOMOV et al. |
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| FUNDED BY |
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| APPLICANT(S) | Old Dominion University Research Foundation (Norfolk, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrei G. PAKHOMOV (Norfolk, Virginia); Olga N. PAKHOMOVA (Norfolk, Virginia); Shu XIAO (Norfolk, Virginia) |
| ABSTRACT | Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306314 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36 (20130101) A61N 1/323 (20130101) Original (OR) Class A61N 1/327 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268661 | Blakeslee et al. |
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| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| INVENTOR(S) | Brigid A. Blakeslee (Manchester, Connecticut); Edward Tunstel, Jr. (Canton, Connecticut) |
| ABSTRACT | A system including a robot mean to move a member by using a first camera coupled to the robot, a second camera coupled to the robot, a control device configured to control position of the robot in order to minimize a pixel-wise distance between the member and a target based on alternating input from the first camera and the second camera. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/187533 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1664 (20130101) B25J 9/1697 (20130101) Original (OR) Class B25J 13/089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210268721 — PHOTOCURABLE, SELF-HEALABLE, AND SHAPE-MEMORIZABLE POLYMERS FOR ADDITIVE MANUFACTURING
| US 20210268721 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiming Wang (Los Angeles, California); Kun-Hao Yu (Los Angeles, California) |
| ABSTRACT | A method of making an ink for use in additive manufacturing of a self-healable and shape-memorizable product includes mixing a diol with isophorone diisocyanate, dimethylacetamide, and dibutyltin dilaurate to form a first solution. The method further includes mixing the first solution with 2-Hydroxyethyl disulfide to form a second solution. The method further includes mixing the second solution with 2-Hydroxyethyl methacrylate to form a third solution. The method further includes mixing the third solution with a tributylphosphine, a photoinitiator, and a photoabsorber to facilitate additive manufacturing of the ink. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185047 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) Original (OR) Class B29C 64/295 (20170801) B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/02 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/242 (20130101) C08G 18/755 (20130101) C08G 18/3825 (20130101) C08G 18/3863 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269318 | REN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | Zhifeng REN (Pearland, Texas); Fei TIAN (Houston, Texas); Gang CHEN (Carlisle, Massachusetts); Bai SONG (Cambridge, Massachusetts); Ke CHEN (Cambridge, Massachusetts); Li SHI (Austin, Texas); Xi CHEN (Austin, Texas); Sean SULLIVAN (Austin, Texas); David BROIDO (Needham, Massachusetts); Navaneetha Krishnan RAVICHANDRAN (Chestnut Hill, Massachusetts) |
| ABSTRACT | A method for growing bulk boron arsenide (BA) crystals, the method comprising utilizing a seeded chemical vapor transport (CVT) growth mechanism to produce single BAs crystals which are used for further CVT growth, wherein a sparsity of nucleation centers is controlled during the further CVT growth. Also disclosed are bulk BAs crystals produced via the method. |
| FILED | Thursday, June 20, 2019 |
| APPL NO | 17/252360 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 35/04 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/61 (20130101) C01P 2006/32 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269366 | Garnier et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Ceramic Fibers, LLC (Idaho falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John E. Garnier (Idaho Falls, Idaho); George W. Griffith (Idaho Falls, Idaho) |
| ABSTRACT | Methods of producing silicon carbide, and other metal carbide materials. The method comprises reacting a carbon material (e.g., fibers, or nanoparticles, such as powder, platelet, foam, nanofiber, nanorod, nanotube, whisker, graphene (e.g., graphite), fullerene, or hydrocarbon) and a metal or metal oxide source material (e.g., in gaseous form) in a reaction chamber at an elevated temperature ranging up to approximately 2400° C. or more, depending on the particular metal or metal oxide, and the desired metal carbide being produced. A partial pressure of oxygen in the reaction chamber is maintained at less than approximately 1.01×102 Pascal, and overall pressure is maintained at approximately 1 atm. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/179642 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/956 (20170801) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/565 (20130101) C04B 35/571 (20130101) C04B 35/573 (20130101) C04B 35/62281 (20130101) Original (OR) Class C04B 2235/46 (20130101) C04B 2235/48 (20130101) C04B 2235/72 (20130101) C04B 2235/428 (20130101) C04B 2235/526 (20130101) C04B 2235/616 (20130101) C04B 2235/767 (20130101) C04B 2235/5244 (20130101) C04B 2235/5248 (20130101) C04B 2235/5264 (20130101) C04B 2235/5284 (20130101) C04B 2235/5445 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/292 (20150115) Y10T 428/2918 (20150115) Y10T 428/2933 (20150115) Y10T 428/2958 (20150115) Y10T 428/2964 (20150115) Y10T 428/2967 (20150115) Y10T 428/2975 (20150115) Y10T 428/24993 (20150401) Y10T 428/249924 (20150401) Y10T 428/249928 (20150401) Y10T 428/249974 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269367 | Gentry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Johnny Ray Gentry (Bellbrook, Ohio); Jeffrey Robert Josken (Dayton, Ohio); Paul Matthew Payer (Demossville, Kentucky) |
| ABSTRACT | An Oxide-Oxide (Ox-Ox) ceramic matrix composite (CMC) component includes a woven high denier ceramic fiber, the fiber comprising a plurality of tows, the woven fiber having interstitial spacing and the tows comprising the fiber having interstitial spacing, an aluminosilicate matrix, wherein the aluminosilicate matrix occupies the interstitial spacing between the fibers, and wherein the aluminosilicate matrix further occupies at least some of the interstitial spacing between the tows of the fiber. In another aspect, a method of fabricating an Oxide-Oxide (Ox-Ox) component includes the steps of providing a ceramic fiber, providing an aluminosilicate slurry, coating the fiber with the aluminosilicate slurry, filament winding the coated fiber over tooling, forming an uncured preform, removing the uncured Ox-Ox preform from the tooling, and curing the Ox-Ox preform, forming a near net shape Ox-Ox component. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 16/804703 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/803 (20130101) Original (OR) Class C04B 35/62236 (20130101) C04B 2235/96 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269492 | O'Malley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Michelle O'Malley (Santa Barbara, California); Kevin Solomon (Lafayette, Indiana); Charles Haitjema (San Jose, California) |
| ABSTRACT | Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/321941 |
| CURRENT CPC | Peptides C07K 14/37 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/00 (20130101) C12N 9/0006 (20130101) C12N 9/24 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) C12P 21/02 (20130101) C12P 39/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269572 | WAGENER et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (GAINESVILLE, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth B. WAGENER (Gainesville, Florida); Taylor W. GAINES (Chandler, Arizona); Michael BELL (North East, Maryland); Julia Grace PRIBYL (Gainesville, Florida) |
| ABSTRACT | Poly(sulfonic acid)s including a multiplicity of sulfonic acid units separated by alkylene units in a polymer chain or a copolymer chain, the poly(sulfonic acid) having a degree of crosslinking in a range of from about 0.1 to about 30 percent. Methods of preparing poly(sulfonic acid)s having improved mechanical integrity. The methods may include synthesizing a poly(sulfonic acid) by acyclic diene metathesis (ADMET) polymerization and reacting a plurality of double bonds afforded by the ADMET polymerization with a crosslinker. The crosslinking reaction may achieve a degree of crosslinking in a range of from about 0.1 to about 30 percent. |
| FILED | Tuesday, June 25, 2019 |
| APPL NO | 17/256356 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 309/67 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 128/02 (20130101) C08F 228/02 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/12 (20130101) C08G 2261/80 (20130101) C08G 2261/122 (20130101) C08G 2261/135 (20130101) C08G 2261/419 (20130101) C08G 2261/516 (20130101) C08G 2261/592 (20130101) C08G 2261/724 (20130101) C08G 2261/1452 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269646 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Runyao Zhu (Changchun, China PRC); K Zin Htut (Yangon, Myanmar); Saranshu Singla (Sangrur, India); Ali Dhinojwaqla (Akron, Ohio); Christopher Maurer (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Runyao Zhu (Changchun, China PRC); K Zin Htut (Yangon, Myanmar); Saranshu Singla (Sangrur, India); Ali Dhinojwaqla (Akron, Ohio); Christopher Maurer (Cleveland, Ohio) |
| ABSTRACT | In various embodiments, the present invention is directed to a melanin composition extracted from black knot fungus (Apiosporina morbosa) using an acid-base extraction technique. In one or more embodiments, the melanin composition is extracted from the black outer layer of a black knot fungus by obtaining a powder including a black outer part of one or more black knot fungus, adding a quantity of an aqueous solution comprising one or more base, heating the mixture to solubilize a melanin in the aqueous solution to form a black alkaline supernatant containing said melanin, adding one or more acids to said black alkaline supernatant until the melanin precipitates out of said black alkaline supernatant, said melanin precipitate further comprising proteins, carbohydrates, and lipids; collecting the melanin precipitate and adding one or more acids to hydrolyze some or all of said proteins, carbohydrates, and lipids and produce the melanin composition. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135162 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 61/00 (20130101) Original (OR) Class C09B 69/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269943 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sang Jin Lee (Winston-Salem, North Carolina); James J. Yoo (Winston-Salem, North Carolina); Young Min Ju (Winston-Salem, North Carolina); Anthony Atala (Winston-Salem, North Carolina) |
| ABSTRACT | The invention is directed to products and methods for preparing self-seeding vascular constructs generated as a bi-layered electrospun matrices, conjugated with EPC-specific antibodies and anti-thrombogenic agents on the inner surfaces of their lumens. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/316342 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/728 (20130101) A61K 31/729 (20130101) A61K 31/737 (20130101) A61K 35/44 (20130101) A61K 38/39 (20130101) A61K 38/363 (20130101) A61K 38/1858 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) Heterocyclic Compounds C07D 315/00 (20130101) Peptides C07K 16/18 (20130101) C07K 16/46 (20130101) C07K 16/289 (20130101) C07K 16/2896 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) Original (OR) Class D01D 5/0076 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/10 (20130101) D01F 6/92 (20130101) D01F 6/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270253 | Omenetto et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tuffs College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fiorenzo G. Omenetto (Lexington, Massachusetts); Meng Li (Medford, Massachusetts) |
| ABSTRACT | The present application relates to compositions and methods of making flexible composite materials that are capable of moving, on a micro- or macro-scale, in response to an applied magnetic field and localized heat from a heat source. The present disclosure further provides systems and methods of using the flexible composite material as an actuator for performing a mode of actuation. In one embodiment, the flexible composite material forms a wireless actuator that, when irradiated with light, is capable of micro- and macro-scale motion acting through the interplay of optically absorptive elements and low-Curie temperature magnetic particles. |
| FILED | Tuesday, July 02, 2019 |
| APPL NO | 17/257734 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 15/0028 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) Compositions of Macromolecular Compounds C08L 89/04 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/065 (20130101) Original (OR) Class Indexing Scheme Relating to Materials, Material Properties or Material Characteristics for Machines, Engines or Pumps Other Than Non-positive-displacement Machines or Engines F05C 2203/0865 (20130101) F05C 2251/08 (20130101) F05C 2251/12 (20130101) F05C 2253/04 (20130101) Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 37/58 (20130101) H01H 2037/326 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270298 | Leutwyler et al. |
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| FUNDED BY |
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| APPLICANT(S) | KALSI ENGINEERING, INC. (Sugar Land, Texas) |
| ASSIGNEE(S) | KALSI ENGINEERING, INC. (Sugar Land, Texas) |
| INVENTOR(S) | Zachary W Leutwyler (Richmond, Texas); Manmohan S Kalsi (Houston, Texas) |
| ABSTRACT | A flow conditioning assembly comprising an integral elbow flow conditioner and a downstream flow conditioner. The elbow flow conditioner includes a pipe elbow with one or more flow conditioning elements. Each flow conditioning element includes one or more turning guides. Each turning guide is generally circular and radially spaced from one another and an inner surface of the elbow. Spaced vanes maintain the radial spacing of the turning guides. The vanes divide the radial space between the turning guides and pipe elbow into a plurality of flow channels that turn in generally the same direction as the inner surface of the pipe elbow. The downstream flow conditioner comprises a flow conditioning structure within a pipe element. The flow conditioning structure includes one or more flow guides of generally circular form radially spaced from one another and the pipe element. Spaced support vanes maintain the radial spacing of the flow guides. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318851 |
| CURRENT CPC | Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids F15D 1/04 (20130101) Original (OR) Class F15D 1/06 (20130101) F15D 1/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270367 | Augustin, SR. et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin C. Augustin, SR. (Greenwood, Indiana); Florin Mocanu (Columbus, Indiana); Eric M. Osecky (Indianapolis, Indiana); Robert G. Sperry (Columbus, Indiana) |
| ABSTRACT | The present disclosure provides a piston for an internal combustion engine, the piston having a piston body including a first bearing saddle defining a first axis and a second bearing saddle defining a second axis, the first axis being parallel to and spaced from the second axis. A bearing is also provided, the bearing having a first journal having a first body, longitudinal ends, and lateral edges, the first journal defining a first axis, the first journal disposed about approximately 180 degrees of the first axis and a second journal having a second body and defining a second axis, the second journal disposed about approximately 180 degrees of the second axis, the second journal operable to be positioned abutting one of the lateral edges of the first journal when the first and second journals are positioned with the piston. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/125582 |
| CURRENT CPC | Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 3/28 (20130101) Pistons; Cylinders; Sealings F16J 1/02 (20130101) Original (OR) Class F16J 1/08 (20130101) F16J 1/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270405 | Di Carlo et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Di Carlo (Long Beach, California); Brian T. Vaniman (Fountain Valley, California); John P. Leuer (Newport Beach, California) |
| ABSTRACT | A method of fabricating a conduit comprises steps of attaching a first tubular-outboard-ply end of a tubular outboard ply to a first inner collar portion of a first collar with a third weld and attaching a second tubular-outboard-ply end to a second inner collar portion of a second collar with a fifth weld. The method additionally comprises steps of interconnecting the first inner collar portion and a first outer collar portion of the first collar with a first weld and interconnecting the second inner collar portion and a second outer collar portion of the second collar with a sixth weld. The method also comprises attaching a trimmed first corrugated-inboard-ply end to the first outer collar portion with a second weld, attaching a trimmed second corrugated-inboard-ply end to the second outer collar portion with a fourth weld, and communicatively coupling a first sensor with an interstitial space. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314602 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 3/16 (20130101) Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 15/00 (20130101) B21D 21/00 (20130101) B21D 49/00 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 9/06 (20130101) F16L 9/18 (20130101) F16L 13/0218 (20130101) F16L 39/005 (20130101) F16L 59/141 (20130101) Original (OR) Class F16L 59/143 (20130101) F16L 59/147 (20130101) F16L 2201/30 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/182 (20130101) G01M 3/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270509 | Mahmoud et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carrier Corporation (Palm Beach Gardens, Florida) |
| ASSIGNEE(S) | Carrier Corporation (Palm Beach Gardens, Florida) |
| INVENTOR(S) | Ahmad M. Mahmoud (Bolton, Connecticut); Jinliang Wang (Ellington, Connecticut); Frederick J. Cogswell (Glastonbury, Connecticut); Parmesh Verma (South Windsor, Connecticut) |
| ABSTRACT | A method for operating a heat pump (20; 300) includes operating in a cooling mode wherein heat is absorbed by refrigerant in the indoor heat exchanger (26) and rejected by refrigerant in the outdoor heat exchanger (24). The heat pump switches to operation in a heating mode wherein heat is rejected by refrigerant in the indoor heat exchanger, heat is absorbed by refrigerant in the outdoor heat exchanger, and there is an ejector (60) motive flow and ejector secondary flow. In the heating mode a refrigerant pressure (PH) or temperature (TL) is measured and, responsive to the measured refrigerant pressure or temperature, at least one of a fan speed is changed and a needle (132) of the ejector is actuated. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 17/253855 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 41/40 (20210101) F25B 49/02 (20130101) Original (OR) Class F25B 2313/0293 (20130101) F25B 2341/0013 (20130101) F25B 2400/23 (20130101) F25B 2600/11 (20130101) F25B 2700/1931 (20130101) F25B 2700/1933 (20130101) F25B 2700/21162 (20130101) F25B 2700/21163 (20130101) F25B 2700/21174 (20130101) F25B 2700/21175 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270724 | Asenath-Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emily Asenath-Smith (Norwich, Vermont); Garrett R. Hoch (Lebanon, New Hampshire); Christopher J. Donnelly (Piermont, New Hampshire); Jordan M. Hodge (Bradford, Vermont) |
| ABSTRACT | One embodiment is directed to a method of testing a polycrystalline laminate formed on a substrate surface of a substrate which is mounted to a sample holder. The substrate surface includes a substrate length edge having a substrate length and a substrate width edge having a substrate width. The polycrystalline laminate has a notch extending beyond the substrate width edge of the substrate surface. The method comprises at least one of: for tensile cleavage testing, applying a tensile load on the notch of the polycrystalline laminate in a direction generally perpendicular to the substrate surface and away from the substrate surface; and for shear sliding testing, applying a shear load on the end of the polycrystalline laminate in a length direction generally parallel to the substrate length edge of the substrate surface. A notch edge formation piece and a notch end formation piece may be used to form the laminate. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/169203 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 19/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270897 | Bose et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pradip Bose (Yorktown Heights, New York); Alper Buyuktosunoglu (White Plains, New York); Schuyler Eldridge (Ossining, New York); Karthik V. Swaminathan (Mount Kisco, New York); Yazhou Zu (Austin, Texas) |
| ABSTRACT | Techniques facilitating determination and correction of physical circuit event related errors of a hardware design are provided. A system can comprise a memory that stores computer executable components and a processor that executes computer executable components stored in the memory. The computer executable components can comprise a simulation component that injects a fault into a latch and a combination of logic of an emulated hardware design. The fault can be a biased fault injection that can mimic an error caused by a physical circuit event error vulnerability. The computer executable components can also comprise an observation component that determines one or more paths of the emulated hardware design that are vulnerable to physical circuit event related errors based on the biased fault injection. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/192164 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/31704 (20130101) G01R 31/318357 (20130101) Original (OR) Class Electric Digital Data Processing G06F 30/00 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210271021 | Puckett et al. |
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| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | Matthew Wade Puckett (Phoenix, Arizona); Karl D. Nelson (Plymouth, Minnesota) |
| ABSTRACT | An optical coupler device comprises an optical waveguide having a first edge and an opposing second edge that extend in a direction substantially parallel to a propagation direction of an input light beam injected into the optical waveguide. A grating structure is on a portion of the optical waveguide, with the grating structure having a first side and an opposing second side. The first and second sides of the grating structure extend in the same direction as the first and second edges of the optical waveguide. An optical slab adjoins with the first side of the grating structure and is in optical communication with an output of the grating structure. The grating structure includes an array of grating lines configured to diffract the input light beam into the slab at an angle with respect to the propagation direction, such that a diffracted light beam is output from the slab. |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 16/803712 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/124 (20130101) Original (OR) Class G02B 6/02128 (20130101) G02B 6/12014 (20130101) G02B 27/4272 (20130101) G02B 2006/12061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210271027 | Williams et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremiah Williams (Dayton, Ohio); Hengky Chandrahalim (Beavercreek, Ohio) |
| ABSTRACT | A passive microscopic Fabry-Pérot Interferometer (FPI) sensor includes a three-dimensional microscopic optical structure formed on a cleaved tip of the optical fighter using a two-photon polymerization process on a photosensitive polymer by a three-dimensional micromachining device. The three-dimensional microscopic optical structure having a hinged optical layer pivotally connected to a distal portion of a suspended structure. A reflective layer is deposited on a mirror surface of the hinged optical layer while in an open position. The hinged optical layer is subsequently positioned in the closed position to align the mirror surface to at least partially reflect a light signal back through the optical fiber. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237128 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/02033 (20130101) G02B 6/29358 (20130101) G02B 6/29359 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272008 | OLIVER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); SOCPRA SCIENCES ET GENIE S.E.C. (Sherbrooke, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William D. OLIVER (Arlington, Massachusetts); Simon GUSTAVSSON (Cambridge, Massachusetts); Roni WINIK (Somerville, Massachusetts); Catherine LEROUX (Sainte Julie, Canada); Agustin DI PAOLO (Sherbrooke, Canada); Alexandre BLAIS (Sherbrooke, Canada) |
| ABSTRACT | A quantum circuit called a “qumon” is provided to cancel unwanted ZZ interaction in a superconducting qubit architecture. The qumon qubit has a high coherence, and a positive anharmonicity that may be tuned to cancel the negative anharmonicity in a coupled qubit, such as a transmon qubit. The qumon has three parallel branches, in which are a shunt capacitor; a Josephson junction having weighted energy level and capacitance; and several Josephson junctions in series. The weight is chosen to provide the desired anharmonicity, and the transverse flux noise and transverse charge noise each decrease in proportion to the number of the Josephson junctions in series. Because unwanted ZZ interactions are canceled, qumon qubits and transmon qubits may be capacitively coupled in an alternating pattern to provide a surface code in which these interactions are canceled in an extensible way. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188461 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/025 (20130101) H01L 39/223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272217 | Shu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kai Shu (Tempe, Arizona); Suhang Wang (Tempe, Arizona); Jiliang Tang (Tempe, Arizona); Yilin Wang (Tempe, Arizona); Huan Liu (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Kai Shu (Tempe, Arizona); Suhang Wang (Tempe, Arizona); Jiliang Tang (Tempe, Arizona); Yilin Wang (Tempe, Arizona); Huan Liu (Tempe, Arizona) |
| ABSTRACT | Various embodiments of systems and methods for cross media joint friend and item recommendations are disclosed herein. |
| FILED | Monday, July 29, 2019 |
| APPL NO | 16/525148 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6249 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0282 (20130101) G06Q 50/01 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272321 | Jolliff |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason K. Jolliff (Slidell, Louisiana) |
| ABSTRACT | Systems and methods are provided for color-enhancing satellite data in a manner that is specific to the true color ocean signal, i.e., the light that is emanating from the ocean surface. These color enhanced images, in turn, can be used as a scientific research and monitoring tool for studying the coastal ocean. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176988 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/1021 (20130101) B64G 2001/1028 (20130101) Image Data Processing or Generation, in General G06T 7/90 (20170101) Original (OR) Class G06T 2207/10024 (20130101) G06T 2207/10032 (20130101) Pictorial Communication, e.g Television H04N 9/67 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272694 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Sacheth Chandramouli (Chicago, Illinois); Patrick Leo (Honeoye Falls, New York); Andrew Janowczyk (East Meadow, New York) |
| ABSTRACT | Embodiments discussed herein facilitate determination of a likelihood of biochemical recurrence (BCR) of cancer (e.g., prostate cancer, etc.). One example embodiment is a method, comprising: accessing at least a portion of a digitized stained histology slide comprising a tumor; automatically segmenting, via a trained deep learning (DL) model, cribriform morphology in connection with the tumor on the at least the portion of the digitized stained histology slide; determining a cribriform-to-tumor area ratio (CAR) based at least in part on an area of the segmented cribriform morphology and an area of the tumor; and determining a risk of biochemical recurrence (BCR) of a cancer associated with the tumor based at least in part on the CAR. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140544 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30096 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/20 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/70 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272771 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kieran Wilson (Oviedo, Florida); Miles Bengtson (Broomfield, Colorado); Hanspeter Schaub (Golden, Colorado); Dalton Turpen (Boulder, Colorado) |
| ABSTRACT | Various embodiments of the present technology generally relate to devices and methods for generating and directing energetic electrons toward a target. More specifically, some embodiments relate to devices, systems, and methods for generating and directing energetic electrons based in the photoelectric effect and directing electric field-focused beams of the energetic electrons toward a target. Electron guns according to the present technology include one or more light sources to stimulate electron transmission, and a series of differentially charged stages to provide a hollow path allowing electrons generated by the photoelectric effect of the light irradiated on interior surfaces defining the path through the stages to travel to an exit of the electron gun. Each of the differentially charged stages have a different potential, thereby providing electrons having two or more different and tunable energy levels exiting as a beam from the electron gun. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186835 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/065 (20130101) H01J 37/305 (20130101) Original (OR) Class H01J 2237/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210273250 | Glaven et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah M. Glaven (Washington, District of Columbia); Lina Bird (Washington, District of Columbia); Leonard M. Tender (Bethesda, Maryland) |
| ABSTRACT | “Biocathode MCL,” designated for its main bacterial constituents (Marinobacter, Chromatiaceae, and Labrenzia), is a stable microbial community enriched from seawater that forms biofilms on the surfaces of electrodes. These biofilms are effective to perform carbon fixation without the need for external electrical power nor sunlight applied thereto. |
| FILED | Wednesday, December 09, 2020 |
| APPL NO | 17/116830 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/34 (20130101) C02F 11/02 (20130101) Apparatus for Enzymology or Microbiology; C12M 25/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210273251 | Bond et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Lanford Bond (San Diego, California); Yolanda Meriah Arias-Thode (San Diego, California); Lewis Hsu (Oahu, Hawaii); David Bart Chadwick (San Diego, California) |
| ABSTRACT | A benthic microbial fuel cell comprising: a nonconductive frame having an upper end and a lower end; a plurality of anodes, wherein each anode is a conductive plate having a top section and a bottom edge; a plurality of conductive, threaded rods disposed perpendicularly to the anode plates and configured to secure the top sections of the anodes to the lower end of the frame and to hold the plates in a substantially parallel orientation with respect to each other such that none of the plates are in direct contact with each other; and a plurality of cathodes, wherein each cathode is made of carbon cloth connected to the upper end of the frame. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157466 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/96 (20130101) H01M 8/16 (20130101) Original (OR) Class H01M 8/04611 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210273558 | Jacobson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Boris S. Jacobson (Westford, Massachusetts); Steven D. Bernstein (Brighton, Massachusetts); Steven M. Lardizabal (Westford, Massachusetts); Jason Adams (Medway, Massachusetts); Jeffrey R. Laroche (Austin, Texas) |
| ABSTRACT | A power converter assembly is provided and includes high quality factor (Q) shield-to-transistor integrated low-inductance capacitor elements to divert common mode (CM) currents, high Q shield-to-shield integrated low-inductance capacitor elements to compliment line-to-line filter capacitors and high Q baseplate integrated low-inductance capacitor elements to attenuate residual CM currents. |
| FILED | Monday, January 13, 2020 |
| APPL NO | 16/741318 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/36 (20130101) H01F 27/2804 (20130101) H01F 27/2885 (20130101) H01F 2027/2809 (20130101) H01F 2027/2819 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/44 (20130101) Original (OR) Class H02M 1/4258 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/165 (20130101) H05K 2201/086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210273647 | Cox et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lloyd Cox (Tucson, Arizona); Matti R. Ingraham (Tucson, Arizona); David R. Mielke (Tucson, Arizona); Dan R, Sheen (Tucson, Arizona); Rhett Hayden (Oro Valley, Arizona) |
| ABSTRACT | Embodiments of a telemetry device and methods to convert a binary floating point number to a compressed number is described herein. The binary floating point number may comprise a mantissa and an exponent. The telemetry device may determine a first number based on a product of the exponent and a constant, wherein the constant may be proportional to a logarithm of the number two. The telemetry device may determine a second number using one or more bits of the mantissa as an index into a predetermined lookup table. Values of the lookup table may be proportional to logarithms of candidate mantissa values. The telemetry device may determine the compressed number based on rounding of a sum. The sum may include the first and second numbers. The rounding may be based on a predetermined step size. |
| FILED | Thursday, October 03, 2019 |
| APPL NO | 16/592509 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/0307 (20130101) G06F 7/485 (20130101) G06F 7/4876 (20130101) G06F 7/49947 (20130101) Coding; Decoding; Code Conversion in General H03M 7/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210273773 | YI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiang YI (Cambridge, Massachusetts); Kenneth E. KOLODZIEJ (Lexington, Massachusetts); Ruonan HAN (Winchester, Massachusetts) |
| ABSTRACT | A transceiver system is configured to concurrently send TX signals and receive RX signals on an antenna system in the same frequency band. A bi-directional frequency converter circuit modulates the TX signals and RX signals by a modulation frequency. The modulated TX signals and RX are frequency shifted so that they have different frequencies that are not in the same frequency band. For example, the TX signal may be shifted to a higher frequency and the RX signal may be shifted to a lower frequency. Filters can then be used to isolate the TX signal and the RX signal for transmission and/or processing. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185142 |
| CURRENT CPC | Transmission H04B 1/56 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/1461 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210273967 | VELA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Booz Allen Hamilton Inc. (McLean, Virginia) |
| ASSIGNEE(S) | Booz Allen Hamilton Inc. (McLean, Virginia) |
| INVENTOR(S) | Chelsea VELA (San Antonio, Texas); Justin HOFFMAN (Boerne, Texas) |
| ABSTRACT | A system for generating a cyber-attack to penetrate a network. The system includes an identification module configured to identify at least one vulnerability of the network by examining at least one of a node of the network, data transmission within the network, or data received from a cyber defense mechanism; a generation module configured to generate a cyber-attack based on the at least one vulnerability of the network, and a goal to be achieved by the cyber-attack. The system includes a penetration module configured to penetrate the network with the cyber-attack and determine an effectiveness rating of the penetration; and a feedback module configured to provide a feedback to the identification module based on at least the effectiveness rating of the penetration. |
| FILED | Wednesday, June 26, 2019 |
| APPL NO | 16/453212 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) H04L 63/1433 (20130101) Original (OR) Class H04L 63/1466 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210274594 | Jakusz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| ASSIGNEE(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| INVENTOR(S) | Jason J. Jakusz (Nixa, Missouri); Titus N. Thompson (Marion, Iowa) |
| ABSTRACT | A system and method for dynamic mesh network discovery is disclosed. In embodiments, the system assigns each network asset (e.g., unmanned or manned aircraft or like mobile nodes) a unique asset number. Each asset has a controller coupled to a datalink including antenna elements and a memory for storing an asset table. Each asset periodically broadcasts an asset status message including the asset number. When a status message is received, the receiving asset compares the received asset number to its own asset number. If the received asset number is higher (e.g., of lower priority) than its own asset number, the receiving asset establishes a bidirectional mesh network connection to the broadcasting asset. Assets on the receiving end of a network connection interrogate the establishing asset for its asset number, such that assets on both sides of the connection know the identity of the other and update their asset tables accordingly. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188458 |
| CURRENT CPC | Wireless Communication Networks H04W 4/06 (20130101) H04W 4/80 (20180201) H04W 76/11 (20180201) H04W 84/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210267492 | FRY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Katelyn Elizabeth FRY (Atlanta, Georgia); Faraz Muhammad YOUSUF (Indianapolis, Indiana); Yu-Ping CHEN (Alpharetta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katelyn Elizabeth FRY (Atlanta, Georgia); Faraz Muhammad YOUSUF (Indianapolis, Indiana); Yu-Ping CHEN (Alpharetta, Georgia); Ayanna Howard (Atlanta, Georgia) |
| ABSTRACT | Systems and methods for detecting a motor developmental delay and/or neurodevelopmental disorder of an infant are described herein. An example method can include receiving motion data associated with the infant's gross motor activity; analyzing, using a machine learning algorithm, the motion data to detect a kinematic feature; comparing the kinematic feature to an expected relationship between the kinematic feature and infant age; and detecting the neurodevelopmental disorder based on the comparison. An infant sensor suit is also described herein. An example infant sensor suit can include an article of clothing; a plurality of sensors; a power source operably coupled to the sensors; and a wireless transmitter operably coupled to the sensors. The sensors, power source, and wireless transmitter can be incorporated into the article of clothing. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/261230 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0024 (20130101) A61B 5/1118 (20130101) A61B 5/1121 (20130101) A61B 5/1123 (20130101) A61B 5/1124 (20130101) Original (OR) Class A61B 5/4082 (20130101) A61B 5/6829 (20130101) A61B 5/7267 (20130101) A61B 5/7282 (20130101) A61B 2503/045 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267746 | MacEwan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew R. MacEwan (St. Louis, Missouri); Jingwei Xie (Chesapeake, Ohio); Zack Ray (St. Louis, Missouri); Younan Xia (Atlanta, Georgia) |
| ABSTRACT | A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229171 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/02 (20130101) Original (OR) Class A61F 2/0063 (20130101) A61F 2/105 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/22 (20130101) A61L 15/42 (20130101) A61L 27/14 (20130101) A61L 27/50 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/05 (20190201) B29C 48/142 (20190201) Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0076 (20130101) D01D 5/0092 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/728 (20130101) D04H 3/016 (20130101) D04H 3/073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267826 | Cooper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Govemment as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rory Alan Cooper (Gibsonia, Pennsylvania); Chengshiu Chung (Pittsburgh, Pennsylvania); Garrett G. Grindle (Pittsburgh, Pennsylvania); Rosemarie Cooper (Gibsonia, Pennsylvania); Sathish Andrea Sundaram (Pittsburgh, Pennsylvania) |
| ABSTRACT | A wheelchair system includes a wheelchair including a plurality of force sensors including at least three force sensors. A rigid seat pan is placed in contact with each the plurality of force sensors at a different position on the rigid seat pan so that the rigid seat pan does not contact the frame and forces on the rigid seat pan are transferred to the plurality of force sensors. Each of the plurality of force sensors is in communicative connection with a processor system. A memory system is in communicative connection and an interface system is in connection with the processor system and a user interface system in communicative connection with the processor system. Instructions stored on the memory system are executable by the processor system to determine a value of a variable related to a distribution of force on the rigid seat pan over time. |
| FILED | Thursday, July 11, 2019 |
| APPL NO | 17/259173 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/128 (20161101) A61G 5/1043 (20130101) A61G 5/1091 (20161101) Original (OR) Class A61G 2203/32 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 40/63 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268128 | Harmsen |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan Harmsen (Menlo Park, California) |
| ABSTRACT | Biodegradable fluorescent silica nanoparticle (FSN) are provided for in vivo imaging, particularly of cancerous and precancerous lesions in the gastrointestinal tract. The FSN are comprised of (a) a dye that fluoresces in the near infrared spectrum which is (i) covalently joined to a silane, and (ii) distributed throughout the nanoparticle; and (b) silica distributed throughout the nanoparticle. The surface may be coated with hydroxyl-terminated PEG, which is shown to reduce uptake of the nanoparticles by the liver. The dyes provide for sensitive detection of clinically relevant lesions, and are biodegradable. |
| FILED | Tuesday, July 09, 2019 |
| APPL NO | 17/253959 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/005 (20130101) A61K 49/0093 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268454 | Weitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Julian W.P. Thiele (Cambridge, Massachusetts); Adam R. Abate (Cambirdge, Massachusetts) |
| ABSTRACT | The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed by urging a fluid into a channel, e.g., by causing the fluid to enter the channel as a “jet.” Side channels can be used to encapsulate the fluid with a surrounding fluid. In some cases, multiple fluids may flow through a channel collinearly before multiple emulsion droplets are formed. The fluidic channels may also, in certain embodiments, include varying degrees of hydrophilicity or hydrophobicity. As examples, the fluidic channel may be relatively hydrophilic upstream of an intersection (or other region within the channel) and relatively hydrophobic downstream of the intersection, or vice versa. In some cases, the average cross-sectional dimension may change, e.g., at an intersection. For instance, the average cross-sectional dimension may increase at the intersection. Surprisingly, a relatively small increase in dimension, in combination with a change in hydrophilicity of the fluidic channel, may delay droplet formation of a stream of collinearly-flowing multiple fluids under certain flow conditions; accordingly, the point at which multiple emulsion droplets are formed can be readily controlled within the fluidic channel. In some cases, the multiple droplet may be formed from the collinear flow of fluids at (or near) a single location within the fluidic channel. In addition, unexpectedly, systems such as those described herein may be used to encapsulate fluids in single or multiple emulsions that are difficult or impossible to encapsulate using other techniques, such as fluids with low surface tension, viscous fluids, or viscoelastic fluids. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 16/951230 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 3/0807 (20130101) Original (OR) Class B01F 13/0062 (20130101) B01F 13/0084 (20130101) B01F 2003/0838 (20130101) B01F 2215/045 (20130101) B01F 2215/0459 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/0318 (20150401) Y10T 137/85938 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268503 | SOPER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF KANSAS (Lawrence, Kansas); THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina); BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (Baton Rouge, Louisiana); NORTHEASTERN UNIVERSITY (Boston, Massachusetts); CLARKSON UNIVERSITY (Potsdam, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. SOPER (Baton Rouge, Louisiana); Collin J. MCKINNEY (Durham, North Carolina); Elizabeth PODLAHA-MURPHY (Potsdam, New York); Sunggook PARK (Baton Rouge, Louisiana) |
| ABSTRACT | Disclosed are nanofluidic analytical devices. The devices employ a sample processing region that includes a plurality of fluidically connected sample handling elements that, in combination, affect a physical change on a sample introduced into the sample processing region. This physical change can include, for example, purification of an analyte of interest present in the sample, concentration of an analyte of interest present in the sample, chemical modification (e.g., cleavage and/or chemical derivatization) of an analyte of interest present in the sample, or a combination thereof. The analytical devices further include a nanochannel comprising a plurality of in-plane nanopores in series fluidically coupled to the sample processing region. The in-plane nanopores can be used to detect and/or analyze analyte(s) present in the sample following processing by the sample processing region. These analytical devices can advantageously provide for the label-free detection of single molecules. |
| FILED | Monday, July 15, 2019 |
| APPL NO | 17/260125 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0645 (20130101) B01L 2300/0896 (20130101) B01L 2400/0415 (20130101) B01L 2400/0421 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210268721 — PHOTOCURABLE, SELF-HEALABLE, AND SHAPE-MEMORIZABLE POLYMERS FOR ADDITIVE MANUFACTURING
| US 20210268721 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qiming Wang (Los Angeles, California); Kun-Hao Yu (Los Angeles, California) |
| ABSTRACT | A method of making an ink for use in additive manufacturing of a self-healable and shape-memorizable product includes mixing a diol with isophorone diisocyanate, dimethylacetamide, and dibutyltin dilaurate to form a first solution. The method further includes mixing the first solution with 2-Hydroxyethyl disulfide to form a second solution. The method further includes mixing the second solution with 2-Hydroxyethyl methacrylate to form a third solution. The method further includes mixing the third solution with a tributylphosphine, a photoinitiator, and a photoabsorber to facilitate additive manufacturing of the ink. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185047 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) Original (OR) Class B29C 64/295 (20170801) B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/02 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/242 (20130101) C08G 18/755 (20130101) C08G 18/3825 (20130101) C08G 18/3863 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268725 | Selter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | Thomas Matthew Selter (Blue Springs, Missouri); Jamie Michael Messman (Leawood, Kansas) |
| ABSTRACT | A system and method of additively manufacturing a part including electrically conductive or static dissipating fluorine-containing polymers. The method includes depositing fluorine-containing polymer additive manufacturing material onto a build platform, selectively cross-linking portions of the deposited additive manufacturing material, and curing the selectively cross-linked portions such that the part is at least one of electrically conductive and static dissipating. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 16/806494 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/20 (20170801) B29C 64/135 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2507/04 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269304 | DWYER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rhode Island Board of Trustees (Kingston, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Rodger DWYER (Providence, Rhode Island); Y.M. Nuwan D. Y. BANDARA (Gonawala, Sri Lanka); Brian SHEETZ (Saunderstown, Rhode Island) |
| ABSTRACT | The present invention provides a simple method for ablating a protective thin film on a bulk surface and roughening the underlying bulk. In an embodiment, silicon nitride thin films, which are useful as etch-stop masks in micro- and nano-fabrication, is removed from a silicon wafer's surface using a hand-held “flameless” Tesla-coil lighter. Vias created by a spatially localized electron beam from the lighter allow a practitioner to perform micro- and nano-fabrication without the conventional steps of needing a photoresist and photolithography. Patterning could be achieved with a hard mask or rastering of the spatially confined discharge, offering—with low barriers to rapid use—particular capabilities that might otherwise be out of reach to researchers without access to conventional, instrumentation-intensive micro- and nano-fabrication workflows. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188985 |
| CURRENT CPC | Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00071 (20130101) Original (OR) Class B81C 2201/0133 (20130101) B81C 2201/0145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210269482 — PEPTOID-PEPTIDE MACROCYCLES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME
| US 20210269482 | KIRSHENBAUM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kent KIRSHENBAUM (New York, New York); Susan LOGAN (New York, New York); Timothy CRAVEN (Seattle, Washington); Amanda KASPER (New York, New York); Richard A. BONNEAU (New York, New York); Jeffrey A. SCHNEIDER (New York, New York) |
| ABSTRACT | Provided are peptoid-peptide macrocycles. The peptoid-peptide macrocycles may have inhibitory activity towards the Wnt signaling pathway. The Wnt signaling pathway is associated with cancer and other diseases and conditions. Such diseases include, for example, pulmonary fibrosis. Also described are methods of making the peptoid-peptide macrocycles, compositions containing the peptoid-peptide macrocycles, and methods of using the peptoid-peptide macrocycles. |
| FILED | Friday, July 12, 2019 |
| APPL NO | 17/259914 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 5/0806 (20130101) C07K 7/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269572 | WAGENER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (GAINESVILLE, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth B. WAGENER (Gainesville, Florida); Taylor W. GAINES (Chandler, Arizona); Michael BELL (North East, Maryland); Julia Grace PRIBYL (Gainesville, Florida) |
| ABSTRACT | Poly(sulfonic acid)s including a multiplicity of sulfonic acid units separated by alkylene units in a polymer chain or a copolymer chain, the poly(sulfonic acid) having a degree of crosslinking in a range of from about 0.1 to about 30 percent. Methods of preparing poly(sulfonic acid)s having improved mechanical integrity. The methods may include synthesizing a poly(sulfonic acid) by acyclic diene metathesis (ADMET) polymerization and reacting a plurality of double bonds afforded by the ADMET polymerization with a crosslinker. The crosslinking reaction may achieve a degree of crosslinking in a range of from about 0.1 to about 30 percent. |
| FILED | Tuesday, June 25, 2019 |
| APPL NO | 17/256356 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 309/67 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 128/02 (20130101) C08F 228/02 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/12 (20130101) C08G 2261/80 (20130101) C08G 2261/122 (20130101) C08G 2261/135 (20130101) C08G 2261/419 (20130101) C08G 2261/516 (20130101) C08G 2261/592 (20130101) C08G 2261/724 (20130101) C08G 2261/1452 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269639 | Coates et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey W. Coates (Lansing, New York); Bryce M. Lipinski (Ithaca, New York); Lilliana S. Morris (Wooster, Ohio) |
| ABSTRACT | Provided are strain-hardened polymers. The polymers may include a plurality of polyether units (e.g., isotactic polypropylene oxide units) and one or more crystalline domains. The strain-hardened polymers may have a higher initial engineering yield stress and/or enthalpy of fusion than native polymer (e.g., polypropylene oxide that has not been strain-hardened). The strain-hardened polymers may be made by catalytic methods using bimetallic catalysts. Also provided are uses of the strain-hardened polymers. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/182152 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 81/00 (20130101) Compositions of Macromolecular Compounds C08L 71/02 (20130101) Original (OR) Class C08L 75/04 (20130101) C08L 2207/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269702 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of North Dakota Center For Innovation (Grand Forks, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanxia Zhou (Grand Forks, North Dakota); Xu Wu (Grand Forks, North Dakota); Julia Xiaojun Zhao (Grand Forks, North Dakota); Hui Pu (Grand Forks, North Dakota) |
| ABSTRACT | A compound for use in oil recovery includes a quantum dot and a zwitterionic surfactant. The quantum dot has a diameter no greater than 25 nm and the quantum dot is bonded to the zwitterionic surfactant. A nanofluid for use in oil recovery includes the compound described above and a fluid carrier. A method for recovering oil from a formation includes flooding the formation with a nanofluid. The nanofluid has a quantum dot diameter no greater than 25 nm bonded to a zwitterionic surfactant and a fluid carrier. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139839 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/584 (20130101) Original (OR) Class C09K 2208/10 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269786 | Kaznessis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yiannis John Kaznessis (New Brighton, Minnesota); Seth Ritter (Minneapolis, Minnesota); Benjamin Hackel (Edina, Minnesota) |
| ABSTRACT | Provided herein are a vector, a genetically modified bacterium including the vector, methods of making the bacterium, methods of using the bacterium, and kits including the bacterium. The vector includes a coding region encoding at least one antimicrobial peptide, and the antimicrobial peptide includes at least one lysin. |
| FILED | Friday, September 07, 2018 |
| APPL NO | 16/645281 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/747 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/2462 (20130101) Original (OR) Class C12N 15/746 (20130101) Enzymes C12Y 302/01017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269813 | Voytas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel F. Voytas (Falcon Heights, Minnesota); Ryan A. Nasti (Minneapolis, Minnesota); Michael F. Maher (St. Paul, Minnesota) |
| ABSTRACT | Materials and methods for inducing genetic alterations in meristematic plant tissue are provided herein. |
| FILED | Wednesday, June 26, 2019 |
| APPL NO | 17/255305 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 4/008 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8213 (20130101) C12N 15/8229 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6895 (20130101) C12Q 2600/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269858 | Chiu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles Chiu (San Francisco, California); Andrea Granados (San Francisco, California); Jennifer A. Doudna (Berkeley, California); Lucas B. Harrington (Berkeley, California); Janice S. Chen (Berkeley, California); Xianding Deng (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods for characterizing a target DNA present in a sample. The methods involve contacting the sample with a type V CRISPR/Cas effector protein and one or more guide RNAs, where the contacting generates a cleavage product comprising a 5′ overhang; and ligating a double-stranded nucleic acid adapter to the cleavage product, to generate a ligation product. The ligation product includes the target DNA, which can be sequenced. The sample can be subjected to one or more amplification steps prior to the contacting step, with primers that provide for amplification of nucleic acids of, e.g., specific pathogens, categories of pathogens, two or more different pathogens, or two or more different categories of pathogens. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319907 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/701 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6888 (20130101) C12Q 1/6893 (20130101) C12Q 1/6895 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270742 | Senger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan Senger (Richmond, Virginia); Pang Du (Blacksburg, Virginia); John L. Robertson (Floyd, Virginia); Yunnan Xu (Blacksburg, Virginia) |
| ABSTRACT | Baseline correction in Raman spectroscopy is a procedure that eliminates/reduces the background signals generated by residual Rayleigh scattering or fluorescence. Provided is a novel baseline correction procedure called the Iterative Smoothing-splines with Root Error Adjustment (ISREA) that has three distinct advantages. First, ISREA uses smoothing splines, which are more flexible than polynomials and capable of capturing complicated trends over the whole spectral domain, to estimate the baseline. Second, ISREA mimics the asymmetric square root loss and removes the need of a threshold. Finally, ISREA avoids the direct optimization of a non-convex loss function by iteratively updating prediction errors and refitting baselines. Through extensive numerical experiments on a wide variety of spectra including simulated spectra, mineral spectra, and dialysate spectra, the present inventors show that ISREA is simple, fast, and can yield consistent and accurate baselines that preserve all the meaningful Raman peaks. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188737 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 5/7264 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) Original (OR) Class G01N 33/493 (20130101) G01N 2201/127 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270771 | Tabib-Azar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | University of Utah Research Foundation (, None) |
| INVENTOR(S) | Massood Tabib-Azar (Salt Lake City, Utah) |
| ABSTRACT | A field effect transistor (FET) biosensor for virus detection of a selected virus within a sample volume is disclosed. The FET comprises a semiconductor substrate, a source and drain electrode on the substrate, the electrodes spaced to form a channel. A gate electrode carried on the substrate and located in the channel between the source and drain electrodes. An insulating layer is coupled to a top surface of the gate electrode and a bottom surface of the source and drain electrodes, with an open channel above the insulating layer. A channel material is coupled to the insulating layer. Aptamers are oriented within the open channel to bind to the channel material and with the selected virus to enable a detection of the selected virus by the FET biosensor based on a change in drain-source current at a selected gate voltage. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/320014 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4145 (20130101) Original (OR) Class G01N 33/5438 (20130101) G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2333/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210270914 | XIAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gang XIAO (Northampton, Massachusetts); Kang WANG (Providence, Rhode Island); Yiou ZHANG (Providence, Rhode Island) |
| ABSTRACT | A magnetic sensing device includes a non-magnetic layer serving as a spacer and two magnetic layers that sandwich the spacer, and two oxide layers that sandwich the trilayer structure including the two magnetic layers and the spacer. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188608 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/072 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/3254 (20130101) H01F 10/3268 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210271148 | YI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ya Sha YI (Troy, Michigan); Da Chuan WU (Ann Arbor, Michigan) |
| ABSTRACT | Beam steering device such as optical phased array (OPA) is a key component in applications of solid-state LIDAR and wireless communication. The traditional single-layer OPA results in a significant energy loss due to the substrate leakage caused by the downward coupling from the grating coupler structure. In the present disclosure, we have investigated a structure based on multi-layers Si3N4/SiO2 platform that can form a 3D OPA to emit the light from the edge of the device with a high efficiency, a 2D converged out-coupling beam will be end-fired to the air. The high efficiency and wide horizontal beam steering are demonstrated numerically, the influence of vertical crosstalk, the delay length, number of waveguide layers, and the fabrication feasibility are also discussed. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/189472 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4814 (20130101) G01S 7/4818 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/292 (20130101) Original (OR) Class G02F 2201/20 (20130101) G02F 2203/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210271683 | IMIELINSKI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tomasz IMIELINSKI (Princeton, New Jersey) |
| ABSTRACT | Data exploration as search over automated pre-generated plot objects can include data analytics systems with automated data mining and simplified user experience front ends. A computer-implemented method, that can be performed by the described data analytics systems, includes receiving a request for plots or plot types of a specified criteria; searching a plot object resource for plots relevant to the specified criteria, the plot object resource comprising an indexed repository of available plots; sorting and ranking the plots or plot types according to associated scores, the associated scores for each plot being based on information theoretic metrics relevant to a measure of interest; and providing plots satisfying a criteria of the sorting and the ranking to a source of the request. |
| FILED | Monday, July 08, 2019 |
| APPL NO | 17/258673 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/24578 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272005 | KING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Atom Computing Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan KING (Berkeley, California); Benjamin BLOOM (Berkeley, California) |
| ABSTRACT | The present disclosure provides methods and systems for performing non-classical computations. The methods and systems generally use a plurality of spatially distinct optical trapping sites to trap a plurality of atoms, one or more electromagnetic delivery units to apply electromagnetic energy to one or more atoms of the plurality to induce the atoms to adopt one or more superposition states of a first atomic state and a second atomic state, one or more entanglement units to quantum mechanically entangle at least a subset of the one or more atoms in the one or more superposition states with at least another atom of the plurality, and one or more readout optical units to perform measurements of the superposition states to obtain the non-classical computation. |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/143029 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272006 | KING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Atom Computing Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan KING (Berkeley, California); Benjamin BLOOM (Berkeley, California); Brian LESTER (Berkeley, California) |
| ABSTRACT | The present disclosure provides methods and systems for performing non-classical computations. The methods and systems generally use a plurality of spatially distinct optical trapping sites to trap a plurality of atoms, one or more electromagnetic delivery units to apply electromagnetic energy to one or more atoms of the plurality to induce the atoms to adopt one or more superposition states of a first atomic state and a second atomic state, one or more entanglement units to quantum mechanically entangle at least a subset of the one or more atoms in the one or more superposition states with at least another atom of the plurality, and one or more readout optical units to perform measurements of the superposition states to obtain the non-classical computation. |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/143030 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/33 (20130101) Optical Computing Devices; G06E 3/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272237 | FANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruogu FANG (Gainesville, Florida); Yao XIAO (Gainesville, Florida) |
| ABSTRACT | Various examples related to CT imaging using multimodal CT image super-resolution are provided. In one example, a method includes generating an enhanced super-resolution generative adversarial network (ESRGAN) by training a generative adversarial network (GAN) with a plurality of CT image modalities (e.g., non-contrast CT, CT Perfusion, CT Angiography, CT with contrast-enhanced, etc.) and generating an enhanced CT image by applying the ESRGAN to a low resolution CT image. In another example, a system includes at least one computing device and program instructions stored in memory and executable in the at least one computing device that, when executed, cause the at least one computing device to generate an ESRGAN by training a GAN with a plurality of CT image modalities and generate an enhanced CT image by applying the ESRGAN to a low resolution CT image. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186471 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 3/4053 (20130101) Original (OR) Class G06T 7/0012 (20130101) G06T 2207/10081 (20130101) G06T 2207/20081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272694 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Sacheth Chandramouli (Chicago, Illinois); Patrick Leo (Honeoye Falls, New York); Andrew Janowczyk (East Meadow, New York) |
| ABSTRACT | Embodiments discussed herein facilitate determination of a likelihood of biochemical recurrence (BCR) of cancer (e.g., prostate cancer, etc.). One example embodiment is a method, comprising: accessing at least a portion of a digitized stained histology slide comprising a tumor; automatically segmenting, via a trained deep learning (DL) model, cribriform morphology in connection with the tumor on the at least the portion of the digitized stained histology slide; determining a cribriform-to-tumor area ratio (CAR) based at least in part on an area of the segmented cribriform morphology and an area of the tumor; and determining a risk of biochemical recurrence (BCR) of a cancer associated with the tumor based at least in part on the CAR. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140544 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30096 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/20 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/70 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272699 | Berson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert E. Berson (Louisville, Kentucky); Javad Hashemi (Louisville, Kentucky); Shahab Ghafghazi (Louisville, Kentucky) |
| ABSTRACT | A non-invasive computer-based method and system for assessing a coronary stenosis or other blockage in an artery or other vasculature includes creating a computational model of the vasculature of interest, modeling blood flow through the vasculature, and determining the mean residence time through a given coronary artery segment, which is a direct assessment of physiological changes on the flow of blood as a result of the stenosis. In some embodiments, blood is modeled as a multi-phase fluid. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/261227 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/029 (20130101) A61B 5/7246 (20130101) A61B 2560/02 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 17/00 (20130101) G06T 2207/10028 (20130101) G06T 2207/30104 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) G16H 50/50 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210273412 | Feezell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel F. Feezell (Albuquerque, New Mexico); Morteza Monavarian (Albuquerque, New Mexico); Saadat M. Mishkat-Ul-Masabih (Albuquerque, New Mexico) |
| ABSTRACT | An electrically injected vertical-cavity surface emitting laser (VCSEL) and a method of manufacturing the same is disclosed. The electrically injected VCSEL includes a non-c-plane substrate and a nanoporous bottom distributed Bragg reflector (DBR) comprising a plurality of alternating highly doped III-nitride layers and unintentionally doped III-nitride layers formed above the substrate. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185868 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/042 (20130101) H01S 5/0206 (20130101) H01S 5/02469 (20130101) H01S 5/18347 (20130101) H01S 5/18361 (20130101) Original (OR) Class H01S 5/34333 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210267458 | Ghosh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kunal Ghosh (San Francisco, California); Laurie D. Burns (Menlo Park, California); Abbas El Gamal (Palo Alto, California); Mark J. Schnitzer (Palo Alto, California); Eric Cocker (Palo Alto, California); Tatt Wei Ho (Stanford, California) |
| ABSTRACT | Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 μm resolution for an image of the field of view. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/080295 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Original (OR) Class A61B 90/20 (20160201) A61B 2090/306 (20160201) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Optical Elements, Systems, or Apparatus G02B 3/0087 (20130101) G02B 21/0008 (20130101) G02B 21/008 (20130101) G02B 21/16 (20130101) G02B 21/36 (20130101) G02B 21/361 (20130101) G02B 21/362 (20130101) G02B 21/365 (20130101) G02B 27/141 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Pictorial Communication, e.g Television H04N 5/2254 (20130101) H04N 5/2256 (20130101) H04N 5/23296 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268132 | Deblonde et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California); THE PENN STATE UNIVERSITY (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gauthier Deblonde (Livermore, California); Yongqin Jiao (Livermore, California); Dan McFarland Park (Livermore, California); Joseph Anthony Mattocks (University Park, Pennsylvania); Joseph Alfred Cotruvo, JR. (University Park, Pennsylvania) |
| ABSTRACT | Provided herein are methods of sequestering target elements (e.g., rare earth elements and/or radiometals) from a sample, methods of purifying target elements from samples, pharmaceutical compositions comprising target elements, and methods of treating a subject with said pharmaceutical compositions. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175228 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/08 (20130101) Original (OR) Class Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/24 (20130101) C22B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268403 | SERVIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anna G. SERVIS (Livermore, California); Narek GHARIBYAN (Livermore, California); Kenton J. MOODY (Livermore, California); Tashi PARSONS-DAVIS (Antioch, California) |
| ABSTRACT | The present disclosure relates to a membrane extraction apparatus for extracting a component from a first liquid. The apparatus may incorporate a housing comprised of first and second mating housing halves, with each housing half having an open faced channel formed therein such that the channels at least partially overlay one another when the two housing halves are secured together. A membrane filter is disposed between the two housing halves to overlay the open faced channels. The membrane filter extracts the component from the first liquid and transfers the component into the second liquid as the first and second liquids flow through the first and second housing halves. |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 16/803393 |
| CURRENT CPC | Separation B01D 11/0496 (20130101) Original (OR) Class B01D 59/02 (20130101) B01D 61/147 (20130101) B01D 63/088 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268445 | LOPRETE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COMPACT MEMBRANE SYSTEMS INC. (Newport, Delaware) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Evan LOPRETE (Cherry Hill, New Jersey) |
| ABSTRACT | An improved method for humidification of a facilitated-transport membrane incorporates delivering a non-selective hydration fluid incorporating liquid water to a permeate side of a pressure vessel containing the facilitated transport membrane. The non-selective hydration fluid includes water and may be configured on the permeate side interface of the facilitated-transport membrane as a liquid or a gas. A process for separation of components in a gaseous mixture utilizing the method for humidification produces higher permeation of gasses through the facilitated transport membrane. The non-selective hydration fluid may be static or flowing and is non-selective for the permeance of certain permeate-gas components over other components. |
| FILED | Thursday, September 26, 2019 |
| APPL NO | 17/276639 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 63/10 (20130101) B01D 65/00 (20130101) Original (OR) Class B01D 71/32 (20130101) Acyclic or Carbocyclic Compounds C07C 7/144 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268446 | Eum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Phillips 66 Company (Houston, Texas); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kiwon Eum (Henderson, Nevada); Shaowei Yang (Atlanta, Georgia); Byunghyun Min (Atlanta, Georgia); Chen Ma (Atlanta, Georgia); Jeffrey H. Drese (Owasso, Oklahoma); Yash Tamhankar (Bartlesville, Oklahoma); Ryan P. Lively (Atlanta, Georgia); Sankar Nair (Roswell, Georgia) |
| ABSTRACT | A method of forming a molecular separation device is provided. The method comprises growing or depositing a silica MFI zeolite coating on a ceramic support. The method further comprises growing a ZIF-8 coating on the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite comprises applying a first reactant fluid including a metal salt and a second reactant fluid including an imidazole reactant to the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite further comprises reacting the first and second reactant fluid with the silica MFI zeolite coating to produce the ZIF-8 coating. In certain implementations, at least a portion of the ZIF-8 coating is interspersed with a portion of the silica MFI coating. A molecular separation device including the ZIF-8 coating and the silica MFI zeolite is also disclosed. |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 16/803291 |
| CURRENT CPC | Separation B01D 67/0079 (20130101) Original (OR) Class B01D 69/148 (20130101) B01D 71/028 (20130101) B01D 71/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268474 | Bai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ExxonMobil Research and Engineering Company (Annandale, New Jersey); TDA Research, Inc. (Wheat Ridge, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chuansheng Bai (Phillipsburg, New Jersey); Majosefina Cunningham (Whitehall, Pennsylvania); Patrick P. McCall (Matawan, New Jersey); Hans Thomann (Bedminster, New Jersey); Jeannine Elizabeth Elliott (Superior, Colorado); Vinh Nguyen (Arvada, Colorado) |
| ABSTRACT | The disclosure generally relates to CCS sorbents, particularly for CO2/H2O displacement desorption process. The sorbents include an aluminum oxide support that includes alkali metal salts within the support, in the form of pseudo alkali aluminate. The sorbents also include alkali metal salt impregnated on the support. The sorbents demonstrate improved CO2 loadings and better H2O/CO2 ratios, as well as improved stability. Compositions and methods of making are disclosed. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/316713 |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/1124 (20130101) B01D 2257/504 (20130101) B01D 2258/0283 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/08 (20130101) Original (OR) Class B01J 20/041 (20130101) B01J 20/3007 (20130101) B01J 20/3078 (20130101) B01J 20/3204 (20130101) B01J 20/3236 (20130101) Capture, Storage, Sequestration or Disposal of Greenhouse Gases [GHG] Y02C 20/40 (20200801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268483 | VARDON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek Richard VARDON (Lakewood, Colorado); Huong Thi Thanh NGUYEN (Denver, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes copper (Cu), aluminum (Al), oxygen, and an element (M) that includes at least one of magnesium, cerium, and/or a transition metal, where the copper and the element are present at a first molar ratio relative to the aluminum between about 0.1:1 and about 30:1 ((Cu+M):Al), and the copper and the element are present at a second molar ratio between about 0.1:4 and about 20:1 (Cu:M). |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188334 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/83 (20130101) Original (OR) Class B01J 35/1014 (20130101) B01J 35/1019 (20130101) B01J 35/1038 (20130101) B01J 35/1042 (20130101) B01J 35/1047 (20130101) B01J 35/1057 (20130101) B01J 35/1061 (20130101) B01J 35/1066 (20130101) Acyclic or Carbocyclic Compounds C07C 29/132 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/02 (20130101) C10L 2200/0469 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268725 | Selter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | Thomas Matthew Selter (Blue Springs, Missouri); Jamie Michael Messman (Leawood, Kansas) |
| ABSTRACT | A system and method of additively manufacturing a part including electrically conductive or static dissipating fluorine-containing polymers. The method includes depositing fluorine-containing polymer additive manufacturing material onto a build platform, selectively cross-linking portions of the deposited additive manufacturing material, and curing the selectively cross-linked portions such that the part is at least one of electrically conductive and static dissipating. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 16/806494 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/20 (20170801) B29C 64/135 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2507/04 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269301 | Feng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhili Feng (Knoxville, Tennessee); Yanli Wang (Knoxville, Tennessee) |
| ABSTRACT | A gaseous hydrogen storage and distribution system with a cryogenic supply and a method for the cryogenic conversion of liquid hydrogen into high-pressure gaseous hydrogen are provided. The gaseous hydrogen storage and distribution system includes pressuring liquid hydrogen from a cryogenic tank using a low pressure liquid pump before vaporization within a relatively small vaporizer. The resulting high pressure gaseous hydrogen is transferred to a plurality of storage tanks at ambient temperature according to a desired fill sequence. The high pressure hydrogen gas is subsequently distributed from the storage tanks through a hydrogen fueling dispenser according to a desired dispensing sequence. The present system and method provide improvements in operational safety, eliminates the use of high pressure gas compressor, and minimizes boiling off and ventilation losses at a reduced cost when compared to existing thermal compression storage systems. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/215035 |
| CURRENT CPC | Separation B01D 5/0048 (20130101) Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/72 (20190201) B60L 53/54 (20190201) Dispensing, Delivering or Transferring Liquids, Not Otherwise Provided for B67D 7/0482 (20130101) Original (OR) Class Non-metallic Elements; Compounds Thereof; C01B 3/00 (20130101) Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 5/002 (20130101) F17C 5/06 (20130101) F17C 7/00 (20130101) F17C 9/02 (20130101) Liquefaction, Solidification or Separation of Gases or Gaseous Mixtures by Pressure and Cold Treatment F25J 3/0655 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269366 | Garnier et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Ceramic Fibers, LLC (Idaho falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John E. Garnier (Idaho Falls, Idaho); George W. Griffith (Idaho Falls, Idaho) |
| ABSTRACT | Methods of producing silicon carbide, and other metal carbide materials. The method comprises reacting a carbon material (e.g., fibers, or nanoparticles, such as powder, platelet, foam, nanofiber, nanorod, nanotube, whisker, graphene (e.g., graphite), fullerene, or hydrocarbon) and a metal or metal oxide source material (e.g., in gaseous form) in a reaction chamber at an elevated temperature ranging up to approximately 2400° C. or more, depending on the particular metal or metal oxide, and the desired metal carbide being produced. A partial pressure of oxygen in the reaction chamber is maintained at less than approximately 1.01×102 Pascal, and overall pressure is maintained at approximately 1 atm. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/179642 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/956 (20170801) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/565 (20130101) C04B 35/571 (20130101) C04B 35/573 (20130101) C04B 35/62281 (20130101) Original (OR) Class C04B 2235/46 (20130101) C04B 2235/48 (20130101) C04B 2235/72 (20130101) C04B 2235/428 (20130101) C04B 2235/526 (20130101) C04B 2235/616 (20130101) C04B 2235/767 (20130101) C04B 2235/5244 (20130101) C04B 2235/5248 (20130101) C04B 2235/5264 (20130101) C04B 2235/5284 (20130101) C04B 2235/5445 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/292 (20150115) Y10T 428/2918 (20150115) Y10T 428/2933 (20150115) Y10T 428/2958 (20150115) Y10T 428/2964 (20150115) Y10T 428/2967 (20150115) Y10T 428/2975 (20150115) Y10T 428/24993 (20150401) Y10T 428/249924 (20150401) Y10T 428/249928 (20150401) Y10T 428/249974 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269377 | Kallupalayam Ramasamy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Karthikeyan Kallupalayam Ramasamy (West Richland, Washington); Mond F. Guo (Richland, Washington); Senthil Subramaniam (Richland, Washington); Udishnu Sanyal (Richland, Washington); Casper O. Brady (Richland, Washington) |
| ABSTRACT | A method for forming a desired hydrocarbon fuel product from a mixed oxygenate feedstock by utilizing chemical processes to form ketones from the oxygenate feed, upgrade the ketones, recycle selected upgraded ketones through the upgrading process to obtain a desired intermediate and hydrogenating the desired intermediate to obtain the desired hydrocarbon fuel product. In various alternative configurations and embodiments this can be accomplished in a number of ways, and originate in a number of different positions and occasions. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318204 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 31/00 (20130101) Acyclic or Carbocyclic Compounds C07C 1/22 (20130101) Original (OR) Class Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 3/44 (20130101) C10G 3/50 (20130101) C10G 2400/08 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/04 (20130101) C10L 2200/04 (20130101) C10L 2290/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269461 | Kung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chung-Wei Kung (Evanston, Illinois); Timothy Chiaan Wang (Pleasonton, California); Joseph T. Hupp (Northfield, Illinois) |
| ABSTRACT | Electrically conductive, metal-organic framework (MOF) materials, methods of making the materials, and chemical sensors incorporating the materials are provided. The electrically conductive MOF materials are formed from mesoporous MOF crystals having continuous strands of electrically conductive inorganic oxides within their porous structures. The inorganic strands are formed by the condensed-phase grafting of molecular metal species onto MOF nodes. |
| FILED | Thursday, July 18, 2019 |
| APPL NO | 17/260101 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/28011 (20130101) B01J 20/28057 (20130101) B01J 20/28071 (20130101) B01J 20/28083 (20130101) B01J 31/1691 (20130101) B01J 2531/48 (20130101) Non-metallic Elements; Compounds Thereof; C01B 37/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/00 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/04 (20130101) G01N 33/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269558 | MIYAKE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado); COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | GARRET MIYAKE (FORT COLLINS, Colorado); JORDAN CORINNE THERIOT (DENVER, Colorado); MATTHEW D. RYAN (LONGMONT, Colorado); RYAN MICHAEL PEARSON (FORT COLLINS, Colorado); TRACY ALLEN FRENCH (FIRCREST, Washington); HAISHEN YANG (SHANGHAI, China PRC); ANDREW LOCKWOOD (Kent, United Kingdom); CHARLES MUSGRAVE (LONGMONT, Colorado); CHERN-HOOI LIM (BOULDER, Colorado); YA DU (SHANGHAI, China PRC); BLAINE MCCARTHY (FORT COLLINS, Colorado) |
| ABSTRACT | The invention provides novel compounds and methods that are useful in promoting reactions that proceed through an oxidative quenching pathway. In certain embodiments, the reactions comprise atom transfer radical polymerization. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/190110 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/0244 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 37/02 (20130101) C07B 39/00 (20130101) C07B 41/00 (20130101) C07B 43/00 (20130101) C07B 45/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/48 (20130101) C08F 2/50 (20130101) Original (OR) Class C08F 4/40 (20130101) C08F 20/14 (20130101) C08F 220/14 (20130101) C08F 220/18 (20130101) C08F 220/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269659 | Nguyen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Du Nguyen (Fremont, California); Eric Duoss (Dublin, California); Jeremy Lenhardt (Tracy, California); Thomas S. Wilson (San Leandro, California) |
| ABSTRACT | The silicone-based ink for additive manufacturing includes a siloxane macromer, and a porogen mixture comprising a water-soluble porogen and a surfactant. The product of additive manufacturing with a silicone-based ink includes a three-dimensional printed structure including a plurality of continuous filaments arranged in a predefined pattern and a plurality of inter-filament pores defined by the predefined pattern of the continuous filaments. In addition, each continuous filament of the three-dimensional printed structure includes a silicone matrix having an open cell structure with a plurality of intra-filament pores, and the intra-filament pores form continuous channels through the silicone matrix. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 16/805494 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/379 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2083/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 70/00 (20141201) B33Y 70/10 (20200101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/037 (20130101) C09D 11/102 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269671 | ZHAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanyang ZHAO (Champaign, Illinois); Nenad MILJKOVIC (Urbana, Illinois) |
| ABSTRACT | A coated substrate that may exhibit anti-scaling properties includes a substrate comprising a metal or alloy, an intermediary layer formed on the substrate, and a non-crosslinked omniphobic coating formed on the intermediary layer. A method of forming an anti-scaling coating on a substrate includes forming an intermediary layer on a substrate comprising a metal or alloy, and forming a non-crosslinked omniphobic coating on the intermediary layer. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/179805 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 183/04 (20130101) Original (OR) Class Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/10 (20130101) C23C 14/021 (20130101) C23C 14/34 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269810 | Geiselman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY AND ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gina Marie Geiselman (Alameda, California); James Kirby (Berkeley, California); Taek Soon Lee (Berkeley, California); John M. Gladden (Alameda, California); Blake A. Simmons (San Francisco, California) |
| ABSTRACT | The present invention provides for a genetically modified fungal host cell capable of producing prespatane and/or epi-isozizaene comprising prespatane synthase (PPS) and/or epi-isozizaene synthase (EIZS). |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/187697 |
| CURRENT CPC | Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/04 (20130101) C10L 2200/043 (20130101) C10L 2270/04 (20130101) C10L 2290/26 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 15/815 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/007 (20130101) Enzymes C12Y 402/03037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210271219 | Buenaventura et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NuScale Power, LLC (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Don Buenaventura (Seattle, Washington); Doug Bowman (Corvallis, Oregon) |
| ABSTRACT | Embodiments are directed to providing a user interface (UI) that streamlines and simplifies the process of monitoring critical power-generation module (PGM) parameters after a PGM assembly is shutdown. The UI displays, in real-time, indicators corresponding to one or more post-shutdown PGM parameters. The UI provides indications of whether the post-shutdown PGM parameters meet post-shutdown criteria of the PGM assembly. When a post-shutdown PGM parameter does not meet the post-shutdown criteria, a user alert is provided to the user. A protocol may additionally be provided to the user. In some embodiments, the protocol may enable the user to return the PGM assembly to a condition that satisfies the post-shutdown criteria. The protocol may be a safety protocol and/or an asset protection protocol. |
| FILED | Thursday, December 24, 2020 |
| APPL NO | 17/133808 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) G05B 19/048 (20130101) Original (OR) Class G05B 23/0267 (20130101) G05B 2219/2639 (20130101) G05B 2219/24015 (20130101) Systems Integrating Technologies Related to Power Network Operation, Communication or Information Technologies for Improving the Electrical Power Generation, Transmission, Distribution, Management or Usage, i.e Smart Grids Y04S 10/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210271526 | Jacob et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip Jacob (Congers, New York); Philip N. Strenski (Yorktown Heights, New York); Charles Johns (Austin, Texas) |
| ABSTRACT | A system and method of supporting point-to-point synchronization among processes/nodes implementing different hardware barriers in a tuple space/coordinated namespace (CNS) extended memory storage architecture. The system-wide CNS provides an efficient means for storing data, communications, and coordination within applications and workflows implementing barriers in a multi-tier, multi-nodal tree hierarchy. The system provides a hardware accelerated mechanism to support barriers between the participating processes. Also architected is a tree structure for a barrier processing method where processes are mapped to nodes of a tree, e.g., a tree of degree k, to provide an efficient way of scaling the number of processes in a tuple space/coordination namespace. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/138540 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/522 (20130101) Original (OR) Class G06F 9/546 (20130101) G06F 9/5072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210271536 | Garzaran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maria Garzaran (Champaign, Illinois); Nusrat Islam (Bee Cave, Texas); Gengbin Zheng (Austin, Texas); Sayantan Sur (Portland, Oregon) |
| ABSTRACT | Algorithms for optimizing small message collectives with hardware supported triggered operations and associated methods, apparatus, and systems. The algorithms are implemented in a distributed compute environment comprising a plurality of ranks including a root, a plurality of intermediate nodes, and a plurality of leaf nodes, where each of the plurality of ranks comprising a compute platform having a communication interface including embedded logic for implementing the algorithms. Collectives are employed to transfer data between parent ranks and child ranks. In connection with the collectives, control messages are sent from children of a collective to the parent of the collective informing the parent that the children of the collective have free buffers ready to receive data. The parent employs a counter to determine that a control message has been received from each of its children indicating each child has a free buffer prior to sending data to the children in the collective. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/133559 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/544 (20130101) G06F 9/546 (20130101) Original (OR) Class G06F 9/5072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210271867 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shusen Liu (Livermore, California); Thomas Han (Livermore, California); Bhavya Kailkhura (Dublin, California); Donald Loveland (Dublin, California) |
| ABSTRACT | A generative attribute optimization (“GAO”) system facilitates understanding of effects of changes of attribute values of an object on a characteristic of the object and automatically identifying attribute values to achieve a desired result for the characteristic. The GAO system trains a generator (encoder and decoder) using an attribute generative adversarial network. The GAO model includes the trained generator and a separately trained predictor model. The GAO model inputs an input image and modified attribute values and employs the encoder and the decoder to generate a modified image that is the input image modified based on the modified attribute values. The GAO model then employs the predictor model to that inputs the modified image and generate a prediction of a characteristic of the modified image. The GAO system may employ an optimizer to modify the attribute values until an objective based on the desired result is achieved. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 16/807006 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00362 (20130101) Original (OR) Class G06K 9/6267 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272658 | Sankaranarayanan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Subramanian Sankaranarayanan (Naperville, Illinois); Troy David Loeffler (Chicago, Illinois); Henry Chan (Schaumburg, Illinois); Mathew J. Cherukara (Darien, Illinois); Srilok Srinivasan (Woodridge, Illinois) |
| ABSTRACT | A system can include one or more processors configured to access at least one parameter of a material, generate a plurality of structures of the material using the at least one parameter, determine a state of each structure of the plurality of structures using the at least one parameter, determine a difference between the state of each structure of the plurality of structures and a ground state value, evaluate a convergence condition responsive to determining the difference between the state of each structure of the plurality of structures and the ground state value, and output at least one structure of the plurality of structures responsive to the convergence condition being satisfied. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 16/807081 |
| CURRENT CPC | Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/30 (20190201) Original (OR) Class G16C 20/80 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210273483 | DING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fei DING (Littleton, Colorado); Weijia LIU (Littleton, Colorado) |
| ABSTRACT | An example system includes an aggregator configured to receive a service collaboration request and iteratively determine, based on minimum and maximum power values for DERs under its management, an optimized operation schedule. The aggregator may also be configured to iteratively determine, based on the optimized operation schedule, an estimated flexibility range for devices under its management and output an indication thereof. The system may also include a power management unit (PMU) configured to iteratively receive the indication and determine, based on a network model that includes the estimated flexibility range, a reconfiguration plan and an overall optimized operation schedule for the network. The PMU may also be configured to iteratively cause reconfiguration of the network based on the plan. The PMU and aggregator may also be configured to iteratively, at a fast timescale, cause energy resources under their management to modify operation based on the overall optimized operation schedule. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188704 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/003 (20200101) H02J 3/004 (20200101) H02J 3/381 (20130101) H02J 9/061 (20130101) H02J 9/068 (20200101) H02J 13/00004 (20200101) Original (OR) Class H02J 2203/10 (20200101) H02J 2300/24 (20200101) H02J 2310/58 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210274633 | Hannon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (Newport News, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fay Hannon (Bjärred, Sweden); Robert Rimmer (Yorktown, Virginia); Shaoheng Wang (Yorktown, Virginia) |
| ABSTRACT | A continuous wave (CW) electron accelerator for the treatment of industrial streams including an electron beam source, a modified high efficiency slot coupled cavity, at least one focusing magnet positioned surrounding the accelerator to contain the beam in the accelerator, an efficient radio frequency power supply means for supplying power of a radio frequency to the cavity to induce a TM01 accelerating mode in the cavity, an electron beam spreader or raster, a fixed magnet array or two-dimensional scanning magnet for deflecting the accelerated beam into a desired shape, and an exit window for extracting the deflected electron beam. The accelerator includes a graded-beta cavity to enable use with a low-power pulsed electron source. The accelerator benefits from a low wall-power loss accelerating cavity that is energized with efficient RF sources, enabling it to be operated in continuous wave mode. |
| FILED | Sunday, December 13, 2020 |
| APPL NO | 17/120178 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/02 (20130101) H05H 7/18 (20130101) H05H 9/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210267826 | Cooper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Govemment as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rory Alan Cooper (Gibsonia, Pennsylvania); Chengshiu Chung (Pittsburgh, Pennsylvania); Garrett G. Grindle (Pittsburgh, Pennsylvania); Rosemarie Cooper (Gibsonia, Pennsylvania); Sathish Andrea Sundaram (Pittsburgh, Pennsylvania) |
| ABSTRACT | A wheelchair system includes a wheelchair including a plurality of force sensors including at least three force sensors. A rigid seat pan is placed in contact with each the plurality of force sensors at a different position on the rigid seat pan so that the rigid seat pan does not contact the frame and forces on the rigid seat pan are transferred to the plurality of force sensors. Each of the plurality of force sensors is in communicative connection with a processor system. A memory system is in communicative connection and an interface system is in connection with the processor system and a user interface system in communicative connection with the processor system. Instructions stored on the memory system are executable by the processor system to determine a value of a variable related to a distribution of force on the rigid seat pan over time. |
| FILED | Thursday, July 11, 2019 |
| APPL NO | 17/259173 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/128 (20161101) A61G 5/1043 (20130101) A61G 5/1091 (20161101) Original (OR) Class A61G 2203/32 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 40/63 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267959 | MORADI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hamid MORADI (Laguna Hills, California); Daniele PIOMELLI (Irvine, California); Kamyar KALANTAR-ZADEH (Palos Verdes Estates, California) |
| ABSTRACT | Disclosed herein, inter alia, are methods of treating renal disease (e.g., chronic kidney disease or end stage renal disease). |
| FILED | Tuesday, July 16, 2019 |
| APPL NO | 17/260188 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4525 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267987 | SHAPIRO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul S. SHAPIRO (Baltimore, Maryland); Alexander D. MACKERELL, JR. (Baltimore, Maryland); Jeffrey D. HASDAY (Timonium, Maryland) |
| ABSTRACT | Compounds that inhibit p38α MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231598 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/54 (20130101) A61K 31/5375 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) A61P 29/00 (20180101) A61P 31/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210267999 | Jensen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ralph Jensen (Washington, District of Columbia) |
| ABSTRACT | Disclosed herein are methods of treating disorders of the retina (e.g., macular degeneration, retinitis pigmentosa, etc.) comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound (for example, an antipsychotic drug) that blocks or diminishes agonist-mediated responses upon binding to either dopamine D2-like receptors or serotonin 5-HT2 receptors. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/322871 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 9/0051 (20130101) A61K 31/40 (20130101) A61K 31/444 (20130101) A61K 31/445 (20130101) A61K 31/451 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/4439 (20130101) A61K 31/5513 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268266 | HAMPSTEAD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin HAMPSTEAD (Ann Arbor, Michigan); Allena HOLZWORTH (Ann Arbor, Michigan); Kevin KRAMER (Ann Arbor, Michigan); Alexander ROTHMANN (Ann Arbor, Michigan); Shannon RYAN (Ann Arbor, Michigan) |
| ABSTRACT | A customizable headgear assembly for neuropsychological and neurological treatment, monitoring, or testing of a patient. The headgear assembly comprising a structural frame having a plurality of anatomical landmark tabs each individually configured to be located upon an anatomical landmark of a patient's head. The structural frame having first and second portions releasably coupled to enable the first and second portions to be at least partially separated for placement and removal from the patient's head. A plurality of electrode holders being operable coupled to the structural frame each configured to locate an electrode upon a predetermined neurological position of the patient. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188437 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/20 (20130101) A61N 1/0456 (20130101) Original (OR) Class A61N 1/0476 (20130101) A61N 1/0484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272694 | Madabhushi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anant Madabhushi (Shaker Heights, Ohio); Sacheth Chandramouli (Chicago, Illinois); Patrick Leo (Honeoye Falls, New York); Andrew Janowczyk (East Meadow, New York) |
| ABSTRACT | Embodiments discussed herein facilitate determination of a likelihood of biochemical recurrence (BCR) of cancer (e.g., prostate cancer, etc.). One example embodiment is a method, comprising: accessing at least a portion of a digitized stained histology slide comprising a tumor; automatically segmenting, via a trained deep learning (DL) model, cribriform morphology in connection with the tumor on the at least the portion of the digitized stained histology slide; determining a cribriform-to-tumor area ratio (CAR) based at least in part on an area of the segmented cribriform morphology and an area of the tumor; and determining a risk of biochemical recurrence (BCR) of a cancer associated with the tumor based at least in part on the CAR. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140544 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30096 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/20 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/70 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210268585 | Hofmann |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Douglas C. Hofmann (Altadena, California) |
| ABSTRACT | Ti-based metal matrix composites, methods of their additive manufacture, and parts manufactured therefrom and thereby are provided. Method include layer-by-layer additive manufacturing for fabricating Ti-based metal matrix composite parts thicker than 0.5 mm, in layers with thickness between 10-1000 micrometers. The parts formed may have one or more of the following properties: a tensile strength greater than 1 GPa, a fracture toughness greater than 40 MPa m1/2, a yield strength divided by the density greater than 200 MPa cm3/g, and a total strain to failure in a tension test greater than 5%. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/202092 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/00 (20210101) B22F 10/20 (20210101) Original (OR) Class B22F 2301/40 (20130101) B22F 2998/00 (20130101) B22F 2999/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Alloys C22C 1/0458 (20130101) C22C 14/00 (20130101) C22C 2200/04 (20130101) C22C 2202/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268661 | Blakeslee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| INVENTOR(S) | Brigid A. Blakeslee (Manchester, Connecticut); Edward Tunstel, Jr. (Canton, Connecticut) |
| ABSTRACT | A system including a robot mean to move a member by using a first camera coupled to the robot, a second camera coupled to the robot, a control device configured to control position of the robot in order to minimize a pixel-wise distance between the member and a target based on alternating input from the first camera and the second camera. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/187533 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1664 (20130101) B25J 9/1697 (20130101) Original (OR) Class B25J 13/089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269126 | Allen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maine System Board of Trustees (Orono, Maine) |
| ASSIGNEE(S) | University of Maine System Board of Trustees (Orono, Maine) |
| INVENTOR(S) | Christopher K. Allen (Bangor, Maine); Anthony M. Viselli (Bangor, Maine); Andrew J. Goupee (Ellsworth, Maine); Habib J. Dagher (Veazie, Maine); Robert E. Berry (Madison, Alabama); Jeffrey L. Lindner (Madison, Alabama); Frederick S. Gant (Huntsville, Alabama); John S. Townsend (Union Grove, Alabama); Rebecca L. Williams (Huntsville, Alabama) |
| ABSTRACT | A motion absorbing system and method for a structure includes the coupling of a container to a structure. The container has a liquid disposed therein wherein a ullage is defined above a surface of the liquid. An elastic element is positioned in the liquid. The elastic element has a natural frequency tuned to damp motion of the liquid. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314201 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 35/44 (20130101) B63B 39/03 (20130101) Original (OR) Class B63B 2035/446 (20130101) Wind Motors F03D 13/25 (20160501) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/93 (20130101) F05B 2240/95 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210271007 | Murphey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Opterus Research and Development, Inc. (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas W. Murphey (Fort Collins, Colorado); Patrick Alexander Rodriguez (Fort Collins, Colorado) |
| ABSTRACT | A doubly curved reflector for compact storage in a folded state includes a plurality of gores, each gore having on either long side a gore side curve. At least one hinge is mechanically coupled between each adjacent gore, the at least one hinge including a fold roll hinge or a living hinge. In a stowed doubly curved reflector state each gore folds about the at least one hinge when folded closed such that a face surface of each gore folds against an adjacent face surface of another gore into a substantially cylindrical structure. In a deployed doubly curved reflector state, each hinge. A doubly curved reflector for compact storage in a folded state and a locked open state, a method of manufacture, and a method for designing a substantially wrinkle free doubly curved foldable reflector having gores of a composite material are also described. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/183550 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/443 (20130101) Optical Elements, Systems, or Apparatus G02B 5/10 (20130101) Original (OR) Class G02B 27/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210271102 | Milster et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. Milster (Tucson, Arizona); Lee C. Johnson (Tucson, Arizona); Eduardo Bendek (San Francisco, California) |
| ABSTRACT | An optical device comprising a freeform optical surface having a diffractive pattern formed thereon and a method and system for forming a diffractive pattern on a freeform optical surface are provided. The diffractive pattern can be formed with sufficient precision that the optical device is suitable for use in a telescope used in astrometry for exoplanet sub-micro-arcsecond resolution. |
| FILED | Saturday, May 18, 2019 |
| APPL NO | 17/056180 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/1814 (20130101) G02B 5/1857 (20130101) G02B 23/02 (20130101) G02B 27/4205 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 5/006 (20130101) Pictorial Communication, e.g Television H04N 5/23229 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210268061 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ONCOIMMUNE, INC. (Rockville, Maryland); UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| ASSIGNEE(S) | ONCOIMMUNE, INC (Rockville, Maryland); UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| INVENTOR(S) | Yang Liu (Baltimore, Maryland); Pan Zheng (Baltimore, Maryland); Martin Devenport (Gaithersburg, Maryland) |
| ABSTRACT | The present invention relates to the use of a CD24 protein for preventing or treating relapse of a cancer in a subject. The present invention also relates to the use of a CD24 protein for reducing cancer stem cell activity. |
| FILED | Monday, June 03, 2019 |
| APPL NO | 15/734957 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) Original (OR) Class A61K 2039/545 (20130101) Peptides C07K 14/70596 (20130101) C07K 16/4241 (20130101) C07K 2317/41 (20130101) C07K 2317/53 (20130101) C07K 2317/524 (20130101) C07K 2317/526 (20130101) C07K 2317/528 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269366 | Garnier et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Ceramic Fibers, LLC (Idaho falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John E. Garnier (Idaho Falls, Idaho); George W. Griffith (Idaho Falls, Idaho) |
| ABSTRACT | Methods of producing silicon carbide, and other metal carbide materials. The method comprises reacting a carbon material (e.g., fibers, or nanoparticles, such as powder, platelet, foam, nanofiber, nanorod, nanotube, whisker, graphene (e.g., graphite), fullerene, or hydrocarbon) and a metal or metal oxide source material (e.g., in gaseous form) in a reaction chamber at an elevated temperature ranging up to approximately 2400° C. or more, depending on the particular metal or metal oxide, and the desired metal carbide being produced. A partial pressure of oxygen in the reaction chamber is maintained at less than approximately 1.01×102 Pascal, and overall pressure is maintained at approximately 1 atm. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/179642 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/956 (20170801) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/565 (20130101) C04B 35/571 (20130101) C04B 35/573 (20130101) C04B 35/62281 (20130101) Original (OR) Class C04B 2235/46 (20130101) C04B 2235/48 (20130101) C04B 2235/72 (20130101) C04B 2235/428 (20130101) C04B 2235/526 (20130101) C04B 2235/616 (20130101) C04B 2235/767 (20130101) C04B 2235/5244 (20130101) C04B 2235/5248 (20130101) C04B 2235/5264 (20130101) C04B 2235/5284 (20130101) C04B 2235/5445 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/292 (20150115) Y10T 428/2918 (20150115) Y10T 428/2933 (20150115) Y10T 428/2958 (20150115) Y10T 428/2964 (20150115) Y10T 428/2967 (20150115) Y10T 428/2975 (20150115) Y10T 428/24993 (20150401) Y10T 428/249924 (20150401) Y10T 428/249928 (20150401) Y10T 428/249974 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272005 | KING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Atom Computing Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan KING (Berkeley, California); Benjamin BLOOM (Berkeley, California) |
| ABSTRACT | The present disclosure provides methods and systems for performing non-classical computations. The methods and systems generally use a plurality of spatially distinct optical trapping sites to trap a plurality of atoms, one or more electromagnetic delivery units to apply electromagnetic energy to one or more atoms of the plurality to induce the atoms to adopt one or more superposition states of a first atomic state and a second atomic state, one or more entanglement units to quantum mechanically entangle at least a subset of the one or more atoms in the one or more superposition states with at least another atom of the plurality, and one or more readout optical units to perform measurements of the superposition states to obtain the non-classical computation. |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/143029 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272006 | KING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Atom Computing Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan KING (Berkeley, California); Benjamin BLOOM (Berkeley, California); Brian LESTER (Berkeley, California) |
| ABSTRACT | The present disclosure provides methods and systems for performing non-classical computations. The methods and systems generally use a plurality of spatially distinct optical trapping sites to trap a plurality of atoms, one or more electromagnetic delivery units to apply electromagnetic energy to one or more atoms of the plurality to induce the atoms to adopt one or more superposition states of a first atomic state and a second atomic state, one or more entanglement units to quantum mechanically entangle at least a subset of the one or more atoms in the one or more superposition states with at least another atom of the plurality, and one or more readout optical units to perform measurements of the superposition states to obtain the non-classical computation. |
| FILED | Wednesday, January 06, 2021 |
| APPL NO | 17/143030 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/33 (20130101) Optical Computing Devices; G06E 3/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210267125 | Lu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Renfu Lu (Okemos, Michigan); ZHAOJIAN Li (ANN ARBOR, Michigan); KYLE LAMMERS (GRAND RAPIDS, Michigan) |
| ABSTRACT | A three-dimensional stereo vision camera communicates the location of a targeted fruit (preferably an apple) to a controller. The controller directs a vacuum selection tube to the location of the targeted apple. The selection tube has a gripping orifice that has a smaller diameter than the apple so that the vacuum suction from the selection tube grips the apple. The selected fruit is then rotated and pulled away from the tree canopy by the selection tube until the apple detaches from the canopy. The detached apple is then gently placed in a collection bin for later sorting and processing. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188177 |
| CURRENT CPC | Harvesting; Mowing A01D 46/24 (20130101) A01D 46/30 (20130101) Original (OR) Class Manipulators; Chambers Provided With Manipulation Devices B25J 9/1697 (20130101) B25J 15/0616 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00657 (20130101) Pictorial Communication, e.g Television H04N 13/204 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210268121 | He |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Kansas (Lawrence, Kansas); Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mei He (Gainesville, Florida) |
| ABSTRACT | Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236561 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6901 (20170801) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/54333 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269311 | CHIU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pei-Chun CHIU (Middletown, Delaware); Danhui XIN (Newark, Delaware); Steven LOBO, II (Raleigh, North Carolina) |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware) |
| INVENTOR(S) | Pei-Chun CHIU (Middletown, Delaware); Danhui XIN (Newark, Delaware); Steven LOBO, II (Raleigh, North Carolina) |
| ABSTRACT | Silver-amended carbon materials containing silver nanoparticles are prepared by a process involving an initial reduction of a porous carbon material, followed by contacting the reduced porous carbon material with an aqueous solution of a silver salt. Such silver-amended carbon materials may contain a relatively high loading of silver nanoparticles on both the outside surface and within the interior of the porous carbon material and are useful for disinfecting and/or otherwise purifying fluids such as microbe-containing fluids. |
| FILED | Friday, July 12, 2019 |
| APPL NO | 17/258798 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/20 (20130101) B01J 2220/4806 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/74 (20130101) C01P 2006/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
General Services Administration (GSA)
| US 20210271778 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tenet 3, LLC (Dayton, Ohio) |
| ASSIGNEE(S) | Tenet 3, LLC (, None) |
| INVENTOR(S) | Kelce S. Wilson (Murphy, Texas); Jeff A. Hughes (Dayton, Ohio); Tyler J. Moody (Fairborn, Ohio); Derek E. Doran (Hilliard, Ohio); Gary R. Tuttle (Middletown, Ohio); Joel B. Rieman (Xenia, Ohio) |
| ABSTRACT | A permissioned blockchain, using off-chain storage, provides advantages over blockchains that rely on consensus and/or store information within the blockchain. Advantages include enhanced viability, compactness, and the ability to register material with distribution limitations (e.g., military classified). Examples create an immutable public record of data signatures that confirm when data is intact, without distributing the data itself, so that widespread availability of the blockchain (beyond those privileged to see the data) advantageously increases the size of the community that is able to detect spoofing or forgery attempts. A permissioning entity limits submissions to manage blockchain growth, foreclosing problematic material that may risk long-term viability. Examples render blockchain operations resistant to advanced persistent threats (APTs), leverage digital signatures as additional trust elements for high-risk data, link records to track pedigree and enable identification of superseded (obsolete) data, and leverage out-of-band date proof to enable independent verification of integrity and no-later-than data-of-existence. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139633 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/64 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3239 (20130101) H04L 9/3247 (20130101) H04L 63/1483 (20130101) H04L 2209/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272771 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kieran Wilson (Oviedo, Florida); Miles Bengtson (Broomfield, Colorado); Hanspeter Schaub (Golden, Colorado); Dalton Turpen (Boulder, Colorado) |
| ABSTRACT | Various embodiments of the present technology generally relate to devices and methods for generating and directing energetic electrons toward a target. More specifically, some embodiments relate to devices, systems, and methods for generating and directing energetic electrons based in the photoelectric effect and directing electric field-focused beams of the energetic electrons toward a target. Electron guns according to the present technology include one or more light sources to stimulate electron transmission, and a series of differentially charged stages to provide a hollow path allowing electrons generated by the photoelectric effect of the light irradiated on interior surfaces defining the path through the stages to travel to an exit of the electron gun. Each of the differentially charged stages have a different potential, thereby providing electrons having two or more different and tunable energy levels exiting as a beam from the electron gun. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186835 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/065 (20130101) H01J 37/305 (20130101) Original (OR) Class H01J 2237/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210273806 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tenet 3, LLC (Dayton, Ohio) |
| ASSIGNEE(S) | Tenet 3, LLC (, None) |
| INVENTOR(S) | Kelce S. Wilson (Murphy, Texas); Jeff A. Hughes (Dayton, Ohio); Tyler J. Moody (Fairborn, Ohio); Derek E. Doran (Hilliard, Ohio); Gary R. Tuttle (Middletown, Ohio); Joel B. Rieman (Xenia, Ohio) |
| ABSTRACT | A permissioned blockchain, using off-chain storage, provides advantages over blockchains that rely on consensus and/or store information within the blockchain. Advantages include enhanced viability, compactness, and the ability to register material with distribution limitations (e.g., military classified). Examples create an immutable public record of data signatures that confirm when data is intact, without distributing the data itself, so that widespread availability of the blockchain (beyond those privileged to see the data) advantageously increases the size of the community that is able to detect spoofing or forgery attempts. A permissioning entity limits submissions to manage blockchain growth, foreclosing problematic material that may risk long-term viability. Examples render blockchain operations resistant to advanced persistent threats (APTs), leverage digital signatures as additional trust elements for high-risk data, link records to track pedigree and enable identification of superseded (obsolete) data, and leverage out-of-band date proof to enable independent verification of integrity and no-later-than data-of-existence. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139672 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0643 (20130101) H04L 9/3218 (20130101) Original (OR) Class H04L 9/3247 (20130101) H04L 2209/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 20210268483 | VARDON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek Richard VARDON (Lakewood, Colorado); Huong Thi Thanh NGUYEN (Denver, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes copper (Cu), aluminum (Al), oxygen, and an element (M) that includes at least one of magnesium, cerium, and/or a transition metal, where the copper and the element are present at a first molar ratio relative to the aluminum between about 0.1:1 and about 30:1 ((Cu+M):Al), and the copper and the element are present at a second molar ratio between about 0.1:4 and about 20:1 (Cu:M). |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188334 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/83 (20130101) Original (OR) Class B01J 35/1014 (20130101) B01J 35/1019 (20130101) B01J 35/1038 (20130101) B01J 35/1042 (20130101) B01J 35/1047 (20130101) B01J 35/1057 (20130101) B01J 35/1061 (20130101) B01J 35/1066 (20130101) Acyclic or Carbocyclic Compounds C07C 29/132 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/02 (20130101) C10L 2200/0469 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210269812 | PENNELL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CERES, INC. (THOUSAND OAKS, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ROGER I. PENNELL (MALIBU, California); WUYI WANG (NEWBURY PARK, California); CHUAN-YIN WU (NEWBURY PARK, California); DWARKESH PARIHAR (HYDERABAD, India); PARESH VERMA (HYDERABAD, India); VIJAY R. KUMAR (HYDERABAD, India); SHRIDHAR J. RAO (HYDERABAD, India) |
| ABSTRACT | Methods and materials for increasing abiotic stress tolerance in plants are disclosed. For example, nucleic acids encoding abiotic stress tolerance-increasing polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased tolerance to abiotic stress and methods of increasing plant yield under abiotic stress conditions. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181674 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8201 (20130101) C12N 15/8222 (20130101) Original (OR) Class C12N 15/8271 (20130101) C12N 15/8273 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20210272309 | Simpson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Simpson (Vienna, Virginia) |
| ABSTRACT | The present disclosure relates to a system and method for automatically determining a three dimensional size of an item. The system may include an optical sensor scanning a surface of the item being transported on a conveyor spaced apart from the optical sensor by a conveyor distance, the surface including a standard size element having a first dimension. The system may also include a memory storing the first dimension and the conveyor distance. The system may also include a processor configured to calculate a second dimension of the surface based on a scanned image of the surface and a scanned image of the standard size element and the stored first dimension. The processor may obtain an item distance between the optical sensor and the surface and determine a height of the item based on the obtained item distance and the stored conveyor di stance. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186512 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/026 (20130101) G01B 11/043 (20130101) G01B 11/046 (20130101) Image Data Processing or Generation, in General G06T 7/62 (20170101) Original (OR) Class G06T 7/70 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210272326 | Simpson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan J. Simpson (Vienna, Virginia) |
| ABSTRACT | This application relates to a method and a system for compressing a captured image of an item such as a mailpiece or parcel. The system may include a memory configured to store images of a plurality of items captured while the items are being transported and a processor in data communication with the memory. The processor may be configured to receive or retrieve one or more of the captured images, perform a wavelet scattering transform on the one or more captured images, perform deep learning on the wavelet scattering transformed images to classify the wavelet scattering transformed images and compress the classified wavelet scattering transformed images. Various embodiments can significantly improve a compression efficiency, a communication efficiency of compressed data and save a memory space so that the functionality of computing devices is significantly improved. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186479 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00442 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 9/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20210270916 | Szalai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Veronika Ann Szalai (Monrovia, Maryland); Amit Kumar Agrawal (Rockville, Maryland); Nandita Abhyankar (Rockville, Maryland) |
| ABSTRACT | A planar inverse anapole microresonator includes: an anapolic substrate; an anapolic conductor that includes a first and second inverse anapolic pattern; each inverse anapolic pattern including: a semi annular arm that terminates in a first arm tendril and a second arm tendril; and a medial arm terminating at a medial tip, and the medial tip of the first inverse anapolic pattern opposes the medial tip of the second inverse anapolic pattern, such that the medial tip of the first inverse anapolic pattern is separated from the medial tip of the second inverse anapolic pattern by a medial gap, and the planar inverse anapole microresonator produces a magnetic field region that concentrates a magnetic field localized between the medial tip of the first inverse anapolic pattern and the medial tip of the second inverse anapolic pattern in response to the planar inverse anapole microresonator being subjected to microwave radiation. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185184 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101) G01R 33/60 (20130101) G01R 33/3456 (20130101) Original (OR) Class Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Education (ED)
| US 20210268126 | Cai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Li Cai (Warren, New Jersey); Misaal Patel (Avenel, New Jersey); Yi Lisa Lyu (Warren, New Jersey) |
| ABSTRACT | Methods for treating a neurological disorder, such as a traumatic spinal cord injury or traumatic brain injury, or a disorder such as Parkinson's disease or multiple sclerosis are provided. Such methods include administering a therapeutically effective amount of Gsx1 protein (such as a Gsx1-cell penetrating peptide fusion protein), or a nucleic acid molecule encoding such a protein (for example as part of a viral vector), thereby treating the neurological disorder. |
| FILED | Friday, August 16, 2019 |
| APPL NO | 17/268664 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/1709 (20130101) A61K 47/6455 (20170801) A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Treasury (TREASURY)
| US 20210271094 | Phillips et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WAVEFRONT TECHNOLOGY, INC. (Paramount, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger Winston Phillips (Santa Rosa, California); Christopher Chapman Rich (Rancho Palos Verdes, California); Joel Mikael Petersen (Valley Village, California) |
| ABSTRACT | A document, product, or package, such as a banknote, passport or the like comprises structures having dichroic effects that change color with viewing angle in both transmission and reflection. Such structures can be useful as security features that counter the ability to effectively use counterfeit documents, products, packages, etc. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/037511 |
| CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00865 (20130101) Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/24 (20141001) B42D 25/29 (20141001) B42D 25/30 (20141001) B42D 25/45 (20141001) Optical Elements, Systems, or Apparatus G02B 1/10 (20130101) G02B 27/095 (20130101) Original (OR) Class G02B 27/0977 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Geospatial Intelligence Agency (NGA)
| US 20210271854 | Verret et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jody D. Verret (Rockwall, Texas); Corey J. Collard (Plano, Texas) |
| ABSTRACT | Discussed herein are devices, systems, and methods for merging point cloud data with error propagation. A can include reducing a sum aggregate of discrepancies between respective tie points and associated 3D points in first and second 3D images, adjusting 3D error models of the first and second 3D images based on the reduced discrepancies to generate registered 3D images, and propagating an error of the first or second 3D images to the registered 3D image to generate error of the registered 3D images. |
| FILED | Tuesday, February 25, 2020 |
| APPL NO | 16/800819 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00208 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/33 (20170101) G06T 15/20 (20130101) G06T 2207/10028 (20130101) G06T 2207/20081 (20130101) G06T 2207/30168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20210268715 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maine System Board of Trustees (Orono, Maine) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James M. Anderson (Hampden, Maine); Matthew J. Ireland (Old Town, Maine) |
| ABSTRACT | The present disclosure provides a 3D printer including a receiving surface for accepting the accumulation of material layers, and a gantry having a shaft and carriage that is translated along the shaft, and an extruder assembly that is articulated to rotate a printing plane, wherein the extruder assembly is attached to the carriage and the articulated extruder assembly is manipulated to rotate the printing plane away from parallel with the receiving surface. |
| FILED | Tuesday, August 06, 2019 |
| APPL NO | 17/262275 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Original (OR) Class B29C 64/194 (20170801) B29C 64/209 (20170801) B29C 64/241 (20170801) B29C 64/245 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, September 02, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page