FedInvent™ Patent Applications

Application Details for Thursday, September 09, 2021 

This page was updated on Friday, September 10, 2021 at 08:07 AM GMT

Department of Health and Human Services (HHS) 

US 20210274726 Musunuru et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts);  The Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Kiran Musunuru (Cambridge, Massachusetts);  Chad A. Cowan (Boston, Massachusetts);  Derrick J. Rossi (Newton, Massachusetts)
ABSTRACT Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells for treating or preventing genetic blood disorders.
FILED Friday, May 21, 2021
APPL NO 17/327620
CURRENT CPC
Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering
A01G 20/47 (20180201) Original (OR) Class

Domestic Washing or Cleaning; Suction Cleaners in General
A47L 11/24 (20130101)
A47L 11/4088 (20130101)

Spraying Apparatus; Atomising Apparatus; Nozzles
B05B 1/30 (20130101)
B05B 7/0075 (20130101)
B05B 7/2475 (20130101)
B05B 15/60 (20180201)

Cleaning in General; Prevention of Fouling in General
B08B 3/026 (20130101)
B08B 5/02 (20130101)

Street Cleaning; Cleaning of Permanent Ways; Cleaning Beaches; Dispersing Fog in General
E01H 1/0809 (20130101)
E01H 2001/0881 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210274824 Li et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) Xiyan Li (San Ramon, California);  Michael P. Snyder (Stanford, California);  Xin Wang (Palo Alto, California)
ABSTRACT Methods of screening cancerous cells for nutritional weaknesses and methods of treating cancer nutritionally are disclosed. Certain cancers depend on being supplied with one or more nutrients that are non-essential for normal cells. In particular, the invention relates to methods of treating cancer by identifying nutritional weaknesses of cancer cells and using nutritional therapy to suppress cancer by putting a subject on a diet that deprives cancerous cells of a nutrient needed for cancer proliferation and growth. Nutritional therapy can be used to enhance the effectiveness of current cancer treatments.
FILED Thursday, February 18, 2021
APPL NO 17/178979
CURRENT CPC
Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General
A23L 33/30 (20160801) Original (OR) Class
A23L 33/40 (20160801)

Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages
A23V 2002/00 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/185 (20130101)
A61K 31/525 (20130101)
A61K 31/675 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275013 Alvarez et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) New Jersey Institute of Technology (Newark, New Jersey)
ASSIGNEE(S) New Jersey Institute of Technology (Newark, New Jersey)
INVENTOR(S) Tara Lynn Alvarez (Whippany, New Jersey);  Chang Yaramothu (Hackensack, New Jersey);  John Vito d'Antonio-Bertagnolli (Mount Laurel, New Jersey);  Mitchell Scheiman (Bala Cynwyd, Pennsylvania)
ABSTRACT Exemplary embodiments of the present disclosure relate to systems, methods, and apparatus to objectively assess binocular dysfunction for screening, diagnoses, and evaluation of vision/oculomotor function before, during, and after various forms of therapeutic interventions. Systems and methods of the present disclosure diagnose and assess binocular dysfunction objectively and automatically, can render a visual stimulus on one or more displays, and can control accommodative and proximal vergence stimulation of a user's eyes.
FILED Tuesday, June 18, 2019
APPL NO 17/253300
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 3/005 (20130101)
A61B 3/08 (20130101) Original (OR) Class
A61B 3/032 (20130101)
A61B 3/113 (20130101)
A61B 5/7267 (20130101)

Optical Elements, Systems, or Apparatus
G02B 30/36 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275058 Zia et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Jonathan Zia (Atlanta, Georgia);  Omer Inan (Atlanta, Georgia);  Jacob Kimball (Atlanta, Georgia);  Christopher Rozell (Atlanta, Georgia)
ABSTRACT The disclosed technology includes devices and methods for a wearable cardiac monitoring system to determine morphological variability and localization of the wearable cardiac monitoring system. The disclosed technology can include receiving seismocardiographic data, determining a classifier of the seismocardiographic data, determining a signal quality index of the seismocardiographic data, determining a quality of the seismocardiographic data based on the classifier and the signal quality index, and outputting an indication of the quality of the seismocardiographic data to a graphical user interface.
FILED Monday, May 10, 2021
APPL NO 17/316290
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/065 (20130101)
A61B 5/1102 (20130101) Original (OR) Class
A61B 5/7221 (20130101)
A61B 5/7267 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275078 Leuthardt
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S) Eric Leuthardt (St. Louis, Missouri)
ABSTRACT A brain computer interface (BCI) system includes an electroencephalogram (EEG) headset and a computing device communicatively coupled to the EEG headset. The computing device includes a memory, a processor and a display device. The memory stores instructions that, when executed by the processor, cause the processor to monitor, using the EEG headset, current extrinsic network activity and current intrinsic network activity of a patient, generate a current depression index based on the relationship between the current extrinsic network activity and the current intrinsic network activity, and display, on the display device, a representation of the relationship between the current depression index and a baseline depression index previously generated for the patient.
FILED Tuesday, May 25, 2021
APPL NO 17/329629
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/24 (20210101)
A61B 5/165 (20130101)
A61B 5/316 (20210101) Original (OR) Class
A61B 5/369 (20210101)
A61B 5/4848 (20130101)
A61B 5/7405 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275327 Colvin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) WillowWood Global LLC (Mount Sterling, Ohio)
ASSIGNEE(S) WillowWood Global LLC (Mount Sterling, Ohio)
INVENTOR(S) James M. Colvin (Hilliard, Ohio);  Matthew M. Wernke (Tampa, Florida);  Stephen A. Byers (Dublin, Ohio);  Evandro M. Ficanha (Grove City, Ohio)
ABSTRACT A prosthetic foot structure includes a plate assembly having a toe portion and a heel portion. The plate assembly includes a first plate adjoining a second plate along a seam at which the first plate is bonded to the second plate. The seam has an end between the first and second plates, and the first plate is spaced from the second plate across a gap that reaches away from the end of the seam. An attachment structure attaches the first plate to second plate. The attachment structure has a composite composition including a resin material containing reinforcing fibers. The reinforcing fibers reach through the first plate, across the gap, and through the second plate.
FILED Wednesday, March 04, 2020
APPL NO 16/808796
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/66 (20130101) Original (OR) Class
A61F 2002/6621 (20130101)
A61F 2002/6642 (20130101)
A61F 2002/6657 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275484 Sivak et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) University Health Network (Toronto, Canada);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Jeremy M. Sivak (Toronto, Canada);  Izhar Livne-Bar (Toronto, Canada);  John G. Flanagan (Berkeley, California);  Karsten Gronert (Walnut Creek, California);  Jessica Wei (Berkeley, California)
ABSTRACT Methods and compositions for inhibiting or preventing neurodegeneration, specifically hippocampal, cortical, and/or retinal ganglion cell neurons (RGC), and degeneration and/or cell loss or treating related disorders and diseases comprising administering to a subject an effective amount of one or more lipoxin compounds and/or lipoxin analogues such that degeneration and/or cell loss of neurons is inhibited or prevented.
FILED Friday, March 09, 2018
APPL NO 16/492494
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/202 (20130101) Original (OR) Class
A61K 31/557 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275494 JOHNSON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Richard J. JOHNSON (Centennial, Colorado);  Miguel A. LANASPA-GARCIA (Denver, Colorado);  Sondra BLAND (Erie, Colorado)
ABSTRACT The invention relates to the use of one or more fructokinase (ketohexokinase) (KHK) inhibitors to both prevent and treat a wide variety of diseases including, but not limited to, alcohol craving, alcohol addiction, alcohol induced liver disease including fatty liver and cirrhosis.
FILED Tuesday, July 16, 2019
APPL NO 17/261279
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/37 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/16 (20180101)
A61P 25/32 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275505 Lamichhane et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
APPLICANT(S) The Johns Hopkins University (Baltimore, Massachusetts);  University of St. Thomas (St. Paul, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Gyanu Lamichhane (Towson, Maryland);  J. Thomas Ippoliti (St. Paul, Minnesota)
ABSTRACT The present invention is a method of treating or preventing Mycobacterium tuberculosis infection in a subject by administering to the subject an effective amount of oxazolidinone, specifically (N—(((S)-3-(dibenzo[b,e][1,4]dioxin-7-yl)-2-oxooxazolidin-5-yl)methyl)acetamide) or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.
FILED Thursday, May 20, 2021
APPL NO 17/326166
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4245 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275515 Apolo
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The US of America As Represented By The Secretary, Dept. of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S) Andrea B. Apolo (Bethesda, Maryland)
ABSTRACT The present disclosure relates to a method of treating urothelial carcinoma using Cabozantinib, a kinase inhibitor.
FILED Wednesday, September 27, 2017
APPL NO 16/336724
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/47 (20130101) Original (OR) Class
A61K 39/3955 (20130101)
A61K 2039/545 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275535 Gendelman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute on Drug Abuse (NIDA)
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Board of Regents of the University of Nebraska (Lincoln, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Howard Gendelman (Omaha, Nebraska);  Benson Edagwa (Omaha, Nebraska)
ABSTRACT The present invention provides prodrugs and methods of use thereof.
FILED Monday, May 24, 2021
APPL NO 17/303228
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/1641 (20130101)
A61K 31/5365 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/18 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275541 Dietz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Harry C. Dietz (Towson, Maryland);  Joseph Shin (Baltimore, Maryland)
ABSTRACT The instant disclosure provides methods and compositions for the diagnosis, treatment and prevention of a TGFβ2-associated disease, disorder and/or condition, including, e.g., Scleroderma, other fibrotic disease, grade 4 glioblastoma (GBM) and/or Primary Open-Angle Glaucoma (POAG). The disclosure further provides pharmaceutical compositions and kits for the diagnosis, treatment and prevention of TGFβ2-associated diseases, disorders and/or conditions.
FILED Friday, March 16, 2018
APPL NO 16/495098
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/551 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275561 D'Alessio et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Franco D'Alessio (Baltimore, Maryland);  Benjamin David Singer (Oak Park, Illinois);  Landon King (Lutherville, Maryland);  Neil Raj Aggarwal (Clarksville, Maryland)
ABSTRACT The present invention provides methods and compositions for treatment of acute inflammatory diseases or disorders and/or for treatment of lung injury. Certain exemplary methods involve administering an IL-4 polypeptide or fragment thereof possessing cytokine activity or an IL-4 agonist systemically to a subject having an inflammatory disease or disorder and/or a lung injury. Other exemplary methods involve administering an inhibitor of DNA methylation systemically to a subject and/or administering an inhibitor of DNA methylation to a cell population comprising T cells (e.g., Treg cells) for introduction/re-introduction to a subject having an inflammatory disease or disorder and/or a lung injury. Compositions and cells for use in such methods are also provided.
FILED Thursday, December 31, 2020
APPL NO 17/139665
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/166 (20130101)
A61K 31/245 (20130101)
A61K 31/353 (20130101)
A61K 31/502 (20130101)
A61K 31/706 (20130101)
A61K 31/7068 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 11/00 (20180101)
A61P 29/00 (20180101)
A61P 31/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275567 ZAGER et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Richard A. ZAGER (Seattle, Washington);  Ali CM JOHNSON (Mill Creek, Washington)
ABSTRACT The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin B12 and, optionally, agents that impact heme protein metabolism.
FILED Monday, January 04, 2021
APPL NO 17/140295
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 1/0226 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/194 (20130101)
A61K 31/555 (20130101)
A61K 31/714 (20130101) Original (OR) Class
A61K 33/26 (20130101)
A61K 38/42 (20130101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 23/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275569 Gruber et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Aronora, Inc. (Portland, Oregon);  Oregon Health and Science University (Portland, Oregon);  Ionis Pharmaceuticals, Inc. (Carlsbad, California)
ASSIGNEE(S) Aronora, Inc. (Portland, Oregon);  Oregon Health and Science University (Portland, Oregon);  Ionis Pharmaceuticals, Inc. (Carlsbad, California)
INVENTOR(S) Andras Gruber (Portland, Oregon);  Erik Tucker (Portland, Oregon);  Brett P. Monia (Encinitas, California);  Alexey Revenko (San Diego, California)
ABSTRACT Provided herein are methods, compounds, and compositions for safely reducing thrombopoietin in a cell or an individual. Such methods, compounds, and compositions maintain platelet count within a safe hemostatic range. Such methods, compounds, and compositions are useful to safely treat, prevent, or ameliorate a disease that can benefit from platelet count reduction in an individual. Such methods, compounds, and compositions are useful for treating or preventing diseases in which thrombopoietin contributes to the presence or activation of platelets contributes to and promotes disease initiation or progression, and/or adversely affects disease outcome.
FILED Tuesday, July 16, 2019
APPL NO 17/260804
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/712 (20130101)
A61K 31/7115 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 7/02 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275582 Hibbert et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) MOREHOUSE SCHOOL OF MEDICINE (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Jacqueline Hibbert (Stockbridge, Georgia);  Jonathan K. Stiles (Powder Springs, Georgia);  Kayellen Umeakunne (Pittsburgh, Pennsylvania);  Hyacinth I. Hyacinth (Lawrenceville, Georgia)
ABSTRACT A nutritional supplement composition for treating nutritional deficiencies caused by a medical condition in subjects is disclosed. The present application further discloses a method of using a nutritional supplements composition for treating a subject with complications resulting from sickle cell anemia. The method comprises administering to a subject an effective amount of the nutritional supplement.
FILED Monday, May 24, 2021
APPL NO 17/303200
CURRENT CPC
Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General
A23L 33/15 (20160801)
A23L 33/16 (20160801)
A23L 33/17 (20160801)
A23L 33/30 (20160801)
A23L 33/105 (20160801)
A23L 33/115 (20160801)
A23L 33/155 (20160801)
A23L 33/175 (20160801)

Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages
A23V 2002/00 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/07 (20130101)
A61K 31/015 (20130101)
A61K 31/51 (20130101)
A61K 31/59 (20130101)
A61K 31/198 (20130101)
A61K 31/355 (20130101)
A61K 31/375 (20130101)
A61K 31/455 (20130101)
A61K 31/525 (20130101)
A61K 31/675 (20130101)
A61K 31/714 (20130101)
A61K 31/4172 (20130101)
A61K 31/7004 (20130101)
A61K 33/00 (20130101)
A61K 33/06 (20130101)
A61K 33/18 (20130101)
A61K 33/24 (20130101)
A61K 33/26 (20130101)
A61K 33/30 (20130101)
A61K 33/32 (20130101) Original (OR) Class
A61K 36/88 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275585 Medof et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) M. Edward Medof (Cleveland, Ohio);  Feng Lin (Cleveland, Ohio);  Michael G. Strainic (Cleveland, Ohio)
ABSTRACT A method of generating a CD4+FoxP3+ Treg cell, the method includes administering at least one complement antagonist to a naive CD4+ T cell at an amount effective to substantially inhibits C3a receptor (C3aR) and/or C5a receptor (C5aR) signal transduction in the CD4+ T cell, induce TGF-β1 expression of the CD4+ T cell, and induce differentiation of the of the naive CD4+ T cell into a CD4+FoxP3+ Treg cell.
FILED Tuesday, March 02, 2021
APPL NO 17/190297
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class
A61K 38/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275592 Ahmed et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Emory University (Atlanta, Georgia);  St. Jude Children's Hospital, Inc. (Memphis, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Rafi Ahmed (Atlanta, Georgia);  Benjamin Youngblood (Decatur, Georgia)
ABSTRACT This disclosure relates to the genetic modification of DNMT3A gene in immune cells. In certain embodiments, the modified immune cells may be used in adoptive T cells therapies to enhance immune responses against cancer or chronic infections. In certain embodiments, the disclosure relates to deleting, changing, or inserting nucleotides within the DNMT3A gene in immune cells, e.g., human CD8 T cells, such that the DNMT3A gene product does not function for methylation. In certain embodiments, modification of the DNMT3A gene provides an improvement in antigen-specific T cells functions and/or an enhancement of the longevity of the cells.
FILED Tuesday, May 25, 2021
APPL NO 17/330378
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)
A61P 35/00 (20180101)

Peptides
C07K 14/005 (20130101)
C07K 14/70596 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101)
C12N 5/0638 (20130101)
C12N 9/1007 (20130101)
C12N 2510/00 (20130101)
C12N 2740/16033 (20130101)
C12N 2740/16111 (20130101)

Enzymes
C12Y 201/01037 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275595 Zambidis et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Elias Zambidis (Ellicott City, Maryland);  Tea Soon Park (Baltimore, Maryland)
ABSTRACT Compositions are provided compositions comprising tankyrase/PARP (poly-ADP-ribose polymerase, also known as poly-ADP-ribosyltransferase) inhibitor-regulated naïve human induced pluripotent stem cells (N-hiPSCs) and their use in the treatment of vascular disorders.
FILED Friday, February 19, 2021
APPL NO 17/180696
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/28 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/10 (20180101)
A61P 27/02 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0662 (20130101)
C12N 5/0696 (20130101)
C12N 2501/235 (20130101)
C12N 2501/724 (20130101)
C12N 2501/727 (20130101)
C12N 2506/45 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275638 Clifton et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) The Schepens Eye Research Institute, Inc. (Boston, Massachusetts);  Cell Guidance Systems Ltd (Cambridge, United Kingdom)
ASSIGNEE(S)
INVENTOR(S) Julia Oswald Clifton (Medford, Massachusetts);  Christian Pernstich (Cambridge, United Kingdom);  Petr Baranov (Boston, Massachusetts);  Michael Jones (Royston, United Kingdom)
ABSTRACT Described herein are polyhedrin-based slow release growth factor systems and methods of use thereof for neuroprotection of host and donor retinal ganglion cell neurons.
FILED Thursday, March 04, 2021
APPL NO 17/192328
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/185 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/06 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275646 Tsai et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Emily Joy Tsai (New York, New York);  Christos Tzimas (New York, New York)
ABSTRACT The present disclosure provides, inter alia, methods for treating or ameliorating the effect of a cardiopulmonary disease, including right ventricular failure (RVF), in a subject. Also provided are methods for diagnosing the risk of having RVF in a subject, methods for preventing RVF in a subject, methods for preventing non-canonical autophagy, methods for mitigating oxidative stress in mitochondria of a cell, and methods for inhibiting microtubule-mediated active mRNA transfer in a cell. A pharmaceutical composition and treatment methods using such composition are also provided.
FILED Friday, April 30, 2021
APPL NO 17/245531
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7088 (20130101)
A61K 35/761 (20130101)
A61K 38/465 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275651 Steinmetz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Nicole F. Steinmetz (San Diego, California);  Frank Alexander Veliz (Cleveland, Ohio);  Brylee David B. Tiu (Cleveland, Ohio)
ABSTRACT A nanoparticle construct includes a plurality of plant virus or virus-like particles electrostatically coupled to a plurality of nanoparticles having a different surface charge than the plant virus or virus-like particles. The nanoparticle construct upon delivery to a subject can provide a sustained release of the plant virus or virus-like particles and/or nanoparticles to a cell or tissue of the subject.
FILED Friday, July 21, 2017
APPL NO 16/319765
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/0011 (20130101) Original (OR) Class
A61K 39/39 (20130101)
A61K 39/385 (20130101)
A61K 47/6901 (20170801)
A61K 2039/585 (20130101)
A61K 2039/622 (20130101)
A61K 2039/645 (20130101)
A61K 2039/5258 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275659 Lowry et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Christopher A. Lowry (Boulder, Colorado);  Matthew G. Frank (Lousville, Colorado);  Laura Fonken (Austin, Texas);  Steven F. Maier (Boulder, Colorado)
ABSTRACT Methods of treating or preventing stress, anxiety, or postoperative cognitive dysfunction. Also provided are methods of improving resilience in a subject by administering a therapeutically effective amount of isolated Mycobacterium.
FILED Thursday, December 17, 2020
APPL NO 17/125422
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/741 (20130101)
A61K 39/04 (20130101) Original (OR) Class
A61K 2039/542 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275664 Graham et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland);  The Scripps Research Institute (La Jolla, California);  Trustees of Dartmouth College (Hanover, New Hampshire)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland);  The Scripps Research Institute (La Jolla, California);  Trustees of Dartmouth College (Hanover, New Hampshire)
INVENTOR(S) Barney Graham (Rockville, Maryland);  Jason McLellan (Austin, Texas);  Andrew Ward (La Jolla, California);  Robert Kirchdoerfer (La Jolla, California);  Christopher Cottrell (La Jolla, California);  Michael Gordon Joyce (Washington, District of Columbia);  Masaru Kanekiyo (Chevy Chase, Maryland);  Nianshuang Wang (Austin, Texas);  Jesper Pallesen (La Jolla, California);  Hadi Yassine (Doha, Qatar);  Hannah Turner (La Jolla, California);  Kizzmekia Corbett (Wheaton, Maryland)
ABSTRACT Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
FILED Monday, March 08, 2021
APPL NO 17/194834
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/215 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 14/005 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2770/20022 (20130101)
C12N 2770/20034 (20130101)
C12N 2770/20071 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275678 Kohane et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Daniel S. Kohane (Boston, Massachusetts);  Chao Zhao (Boston, Massachusetts)
ABSTRACT Anesthetics covalently conjugated onto biodegradable and biocompatible hydrophilic polymers via hydrolysable linkages provide controlled release of local anesthetics in vivo in an effective amount for nerve blockade with reduced toxicity relative to the unconjugated anesthetic agent. The rate of anesthetic release can be tuned by changing the hydrophilicity of the polymer. Exemplary formulations of Poly (glycerol sebacate) (PGS), optionally including Poly ethylene glycol (PEG) polymers conjugated to Tetrodotoxin (TTX) (PGS-PEG-TTX and PGS-TTX), and methods of use thereof are provided Nerve blockade from PGS-PEG-TTX and PGS-TTX was associated with minimal systemic and local toxicity to the muscle and the peripheral nerves. TDP-TTX conjugates homogeneously dispersed into PEG200 are also described. PEG200 not only worked as a medium, but also worked as a chemical permeation enhancer (CPE) to enhance the effectiveness of TTX.
FILED Monday, December 03, 2018
APPL NO 16/768818
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 31/519 (20130101)
A61K 47/60 (20170801) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275682 Goldenberg
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Immunomedics, Inc. (Morris Plains, New Jersey)
ASSIGNEE(S)
INVENTOR(S) David M. Goldenberg (Delray Beach, Florida)
ABSTRACT The present invention concerns improved methods and compositions for neoadjuvant use of antibody-drug conjugates (ADCs) in cancer therapy, preferably ADCs comprising an anthracycline or camptothecin, more preferably SN-38 or pro-2-pyrrolinodoxorubicin (P2PDox). The ADC is administered as a neoadjuvant, prior to treatment with a standard anti-cancer therapy such as surgery, radiation therapy, chemotherapy, or immunotherapy. Neoadjuvant use of the ADC substantially improves the efficacy of standard anti-cancer therapy and may debulk a primary tumor or eliminate micrometasteses. In most preferred embodiments, neoadjuvant ADC in combination with a standard anti-cancer therapy is successful in treating cancers that are resistant to standard treatments, such as triple-negative breast cancer (TNBC).
FILED Tuesday, February 09, 2021
APPL NO 17/171411
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/704 (20130101)
A61K 31/4745 (20130101)
A61K 45/06 (20130101)
A61K 47/6803 (20170801) Original (OR) Class
A61K 47/6809 (20170801)
A61K 47/6811 (20170801)
A61K 47/6849 (20170801)
A61K 47/6851 (20170801)
A61K 47/6853 (20170801)
A61K 47/6867 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275688 Cepko et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Constance L. Cepko (Newton, Massachusetts);  Wenjun Xiong (Boston, Massachusetts)
ABSTRACT The present invention is directed to methods for the treatment or prevention of oxidative stress in a cell, e.g., photoreceptor cell, and methods for the treatment and prevention of disorders associated therewith by the administration of an agent, e.g., a nucleic acid molecule, which increases the expression and/or activity of an antioxidant defense protein.
FILED Friday, March 19, 2021
APPL NO 17/206212
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7115 (20130101)
A61K 38/446 (20130101)
A61K 38/1709 (20130101)
A61K 45/06 (20130101)
A61K 48/005 (20130101)
A61K 48/0058 (20130101) Original (OR) Class
A61K 48/0075 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 2750/14143 (20130101)

Enzymes
C12Y 115/01001 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275725 Almarza et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania)
ASSIGNEE(S) UNIVERSITY OF PITTSBURGH-OF TH COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania)
INVENTOR(S) Alejandro Almarza (Pittsburgh, Pennsylvania);  Adam Chin (Pembroke Pines, Florida);  Juan Taboas (Pittsburgh, Pennsylvania);  Yadong Wang (Ithaca, New York)
ABSTRACT The invention relates to biodegradable, biocompatible materials to promote regeneration of articular surfaces in the temporomandibular joint and, more particularly, to biomaterials and methods for facilitating fibrochondrocyte and chondrocyte growth in in-vitro and in-vivo environments. The materials include magnesium in solid form and polymer. The materials are effective to grow and regenerate fibrochondrocyte and chondrocyte cells, and restore bone cells.
FILED Monday, September 11, 2017
APPL NO 16/330538
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/56 (20130101)
A61L 27/446 (20130101) Original (OR) Class
A61L 27/3817 (20130101)
A61L 2430/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275802 Bhadra et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Niloy Bhadra (Cleveland Heights, Ohio);  Narendra Bhadra (Chesterland, Ohio);  Kevin L. Kilgore (Avon Lake, Ohio);  Scott Lempka (Cleveland Heights, Ohio);  Jesse Wainright (Willoughby Hills, Ohio);  Tina Vrabec (Willoughby Hills, Ohio);  Manfred Franke (Redwood City, California)
ABSTRACT Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
FILED Thursday, May 13, 2021
APPL NO 17/319180
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/06 (20130101)
A61N 1/20 (20130101)
A61N 1/205 (20130101)
A61N 1/0456 (20130101)
A61N 1/0551 (20130101) Original (OR) Class
A61N 1/0556 (20130101)
A61N 1/3615 (20130101)
A61N 1/36017 (20130101)
A61N 1/36021 (20130101)
A61N 1/36062 (20170801)
A61N 1/36071 (20130101)
A61N 1/36125 (20130101)
A61N 1/36171 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275833 Krishnaswamy et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire);  DOSEOPTICS, LLC (Lebanon, New Hampshire)
ASSIGNEE(S)
INVENTOR(S) Venkataramanan Krishnaswamy (Lebanon, New Hampshire);  Petr Bruza, JR. (Lebanon, New Hampshire);  Michael Jermyn (Lebanon, New Hampshire);  Brian W. Pogue (Hanover, New Hampshire);  David Gladstone (Norwich, New Hampshire);  Lesley A. Jarvis (Hanover, New Hampshire);  Irwin Tendler (Hanover, New Hampshire)
ABSTRACT A Cherenkov-based or thin-sheet scintillator-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light or scintillator-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov light or scintillator light imaging.
FILED Thursday, May 06, 2021
APPL NO 17/313838
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/1045 (20130101)
A61N 5/1049 (20130101)
A61N 5/1071 (20130101) Original (OR) Class
A61N 5/1081 (20130101)
A61N 2005/1054 (20130101)
A61N 2005/1059 (20130101)

Measurement of Nuclear or X-radiation
G01T 1/22 (20130101)
G01T 1/2002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275998 XU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (Louisville, Kentucky)
ASSIGNEE(S) UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (Louisville, Kentucky)
INVENTOR(S) Bo XU (Louisville, Kentucky);  Zhichao LU (Louisville, Kentucky);  Gerald B. HAMMOND (Shelbyville, Kentucky)
ABSTRACT Some embodiments of the invention include inventive catalysts (e.g., catalysts of Formula (I)). Other embodiments include compositions comprising the inventive catalysts. Some embodiments include methods of using the inventive catalysts (e.g., in hydrofluorination of an organic compound). Further embodiments include methods for making the inventive catalysts. Additional embodiments of the invention are also discussed herein.
FILED Monday, July 22, 2019
APPL NO 17/259282
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 31/08 (20130101) Original (OR) Class
B01J 37/26 (20130101)
B01J 37/30 (20130101)
B01J 41/04 (20130101)
B01J 41/12 (20130101)
B01J 47/02 (20130101)
B01J 2231/32 (20130101)
B01J 2231/34 (20130101)
B01J 2231/48 (20130101)

General Methods of Organic Chemistry; Apparatus Therefor
C07B 39/00 (20130101)

Acyclic or Carbocyclic Compounds
C07C 67/287 (20130101)
C07C 209/74 (20130101)

Heterocyclic Compounds
C07D 213/803 (20130101)
C07D 309/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276951 SHAPIRO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S) The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S) David J. SHAPIRO (Urbana, Illinois);  Paul J. HERGENROTHER (Champaign, Illinois);  Matthew W. BOUDREAU (Urbana, Illinois)
ABSTRACT A set of small molecules ERα biomodulators that kill therapy-resistant ERα positive breast, ovarian, and endometrial cancer cells. These small molecules have increased therapeutic potential because of an increased ability to kill therapy-resistant breast cancer cells compared to BHPI and other conventional therapies (endocrine therapies, tamoxifen and fulvestrant/ICI). The new compounds do not only inhibit proliferation of the cancer cells but actually kills them, which prevents reactivation of tumors years later.
FILED Monday, July 01, 2019
APPL NO 17/254771
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 209/34 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276960 Schiltz et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Northwestern University (Evanston, Illinois);  United States Goverment as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Gary E. Schiltz (Naperville, Illinois);  Daniela E. Matei (Chicago, Illinois);  Purav Vagadia (Aurora, Illinois)
ABSTRACT Disclosed are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. The disclosed compounds inhibit the activity of tissue transglutaminase 2 (TG2). As such, the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with TG2 activity which may be cell proliferative diseases and disorders such as cancer.
FILED Wednesday, March 03, 2021
APPL NO 17/249519
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 239/42 (20130101)
C07D 239/48 (20130101) Original (OR) Class
C07D 401/12 (20130101)
C07D 403/12 (20130101)
C07D 409/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276964 Edderkaoui et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S) CEDARS-SINAI MEDICAL CENTER (LOS ANGELES, California)
ASSIGNEE(S)
INVENTOR(S) Mouad Edderkaoui (Los Angeles, California);  Ramachandran Murali (Swarthmore, Pennsylvania);  Stephen Pandol (Los Angeles, California)
ABSTRACT The invention describes compounds that inhibit both HDAC and GSK3β (i.e., HDAC/GSK3β dual inhibitors). The invention further describes compositions containing these HDAC/GSK3β dual inhibitors, as well as methods and kits using these HDAC/GSK3β dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3β to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3β. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.
FILED Thursday, October 08, 2020
APPL NO 17/066397
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/167 (20130101)
A61K 31/433 (20130101)
A61K 31/4245 (20130101)
A61K 45/06 (20130101)

Heterocyclic Compounds
C07D 271/10 (20130101)
C07D 271/107 (20130101)
C07D 271/113 (20130101)
C07D 285/08 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276971 Boros et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Research Foundation for The State University of New York (Albany, New York)
ASSIGNEE(S) The Research Foundation for The State University of New York (Albany, New York)
INVENTOR(S) Eszter Boros (Stony Brook, New York);  Brett Vaughn (Centereach, New York)
ABSTRACT The present invention provides a compound having the structure: and methods of using the compound in targeted PET imaging.
FILED Thursday, June 20, 2019
APPL NO 17/253307
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 51/0482 (20130101)

Heterocyclic Compounds
C07D 401/06 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276996 Gray et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S) Nathanael S. Gray (Boston, Massachusetts);  Tinghu Zhang (Brookline, Massachusetts);  Eric Fischer (Chestnut Hill, Massachusetts);  Guangyan Du (Jamaica Plain, Massachusetts);  Nozhat Safaee (Brookline, Massachusetts);  Nathaniel Henning (Brookline, Massachusetts);  Katherine Donovan (Boston, Massachusetts)
ABSTRACT Disclosed are bifunctional compounds, pharmaceutical compositions containing them, and methods of making and using them to treat diseases and disorders characterized by aberrant protein activity wherein the protein is targeted for degradation by KEAP1 and the Cul3-based E3-ubiquitin ligase complex.
FILED Thursday, July 18, 2019
APPL NO 17/258340
CURRENT CPC
Heterocyclic Compounds
C07D 403/12 (20130101)
C07D 419/14 (20130101) Original (OR) Class
C07D 495/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277007 Jefson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Alkermes, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Martin R. Jefson (Stonington, Connecticut);  John A. Lowe, III (Stonington, Connecticut);  Fabian Dey (Basel, Switzerland);  Andreas Bergmann (Gauting, Germany);  Andreas Schoop (Grafrath, Germany);  Nathan Oliver Fuller (Arlington, Massachusetts)
ABSTRACT This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.
FILED Monday, December 28, 2020
APPL NO 17/134875
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/13 (20130101)
A61K 31/27 (20130101)
A61K 31/40 (20130101)
A61K 31/44 (20130101)
A61K 31/50 (20130101)
A61K 31/55 (20130101)
A61K 31/167 (20130101)
A61K 31/351 (20130101)
A61K 31/415 (20130101)
A61K 31/421 (20130101)
A61K 31/426 (20130101)
A61K 31/427 (20130101)
A61K 31/435 (20130101)
A61K 31/437 (20130101)
A61K 31/444 (20130101)
A61K 31/445 (20130101)
A61K 31/496 (20130101)
A61K 31/505 (20130101)
A61K 31/506 (20130101)
A61K 31/4155 (20130101)
A61K 31/4192 (20130101)
A61K 31/4433 (20130101)
A61K 31/4439 (20130101)
A61K 31/4965 (20130101)
A61K 31/4985 (20130101)
A61K 31/5377 (20130101)
A61K 45/06 (20130101)

Heterocyclic Compounds
C07D 207/06 (20130101)
C07D 309/14 (20130101)
C07D 401/12 (20130101)
C07D 401/14 (20130101)
C07D 403/12 (20130101)
C07D 405/12 (20130101)
C07D 409/12 (20130101)
C07D 413/14 (20130101)
C07D 417/12 (20130101)
C07D 417/14 (20130101)
C07D 471/10 (20130101)
C07D 487/04 (20130101) Original (OR) Class
C07D 487/10 (20130101)
C07D 491/107 (20130101)
C07D 513/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277018 Gray et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S) Nathanael Gray (Boston, Massachusetts);  Tinghu Zhang (Brookline, Massachusetts);  Eric Fischer (Chestnut Hill, Massachusetts);  Alyssa Verano (Allston, Massachusetts);  Zhixiang He (Brookline, Massachusetts);  Guangyan Du (Jamaica Plain, Massachusetts);  Katherine Donovan (Boston, Massachusetts);  Radoslaw Nowak (Boston, Massachusetts);  Jing Ting Christine Yuan (Brookline, Massachusetts)
ABSTRACT Disclosed are degraders, pharmaceutical compositions containing them, and methods of making and using the degraders to treat diseases and disorders characterized by dysregulated or dysfunctional protein activity that can be targeted by cereblon.
FILED Thursday, June 27, 2019
APPL NO 17/255750
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/545 (20170801)

Heterocyclic Compounds
C07D 495/14 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277023 MILLER et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) UNIVERSITY OF NOTRE DAME DU LAC (SOUTH BEND, Indiana)
ASSIGNEE(S) UNIVERSITY OF NOTRE DAME DU LAC (SOUTH BEND, Indiana)
INVENTOR(S) Marvin J. MILLER (Notre Dame, Indiana);  Rui LIU (Notre Dame, Indiana);  Patricia MILLER (Notre Dame, Indiana);  Sergei VAKULENKO (Notre Dame, Indiana);  Nichole K. STEWART (Notre Dame, Indiana);  William BOGGESS (Notre Dame, Indiana)
ABSTRACT Provided are antibiotic conjugate compounds of formula (I) and pharmaceutical compositions thereof. Also provided are methods of treating treat bacterial infection, including infections caused by Gram-negative bacteria, by administering compounds of formula (I).
FILED Thursday, August 09, 2018
APPL NO 17/054054
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Heterocyclic Compounds
C07D 501/60 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277038 BAZIN-LEE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) GLAXOSMITHKLINE BIOLOGICALS, S.A. (, None)
ASSIGNEE(S) GLAXOSMITHKLINE BIOLOGICALS, S.A. (Rixensart, Belgium)
INVENTOR(S) Helene G. BAZIN-LEE (Hamilton, Montana);  Jay T. EVANS (Hamilton, Montana);  David BURKHART (Hamilton, Montana);  Michael COCHRAN (Hamilton, None);  David A. JOHNSON (Hamilton, Montana)
ABSTRACT This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.
FILED Monday, September 05, 2016
APPL NO 16/330599
CURRENT CPC
Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 9/6561 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277059 ARORA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Paramjit S. ARORA (Cold Spring Harbor, New York);  Michael G. WUO (Brooklyn, New York)
ABSTRACT This invention relates to a macrostructure that includes an antiparallel coiled-coil structure shown below or a parallel coiled-coil structure shown below and described in the present application.
FILED Wednesday, August 26, 2020
APPL NO 17/003686
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/02 (20180101)

Peptides
C07K 7/06 (20130101) Original (OR) Class
C07K 14/00 (20130101)
C07K 2319/73 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/68 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277065 HAYNES et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Laboratory (LANL)
Los Alamos National Security, LLC (LANS)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Duke University (Durham, North Carolina);  Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Barton F. HAYNES (Durham, North Carolina);  Mattia BONSIGNORI (Durham, North Carolina);  Hua-Xin LIAO (Durham, North Carolina);  Bette T. KORBER (Los Alamos, New Mexico);  Peter T. HRABER (Los Alamos, New Mexico);  Kevin O. SAUNDERS (Durham, North Carolina)
ABSTRACT In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
FILED Thursday, March 11, 2021
APPL NO 17/199319
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/21 (20130101)
A61K 39/39 (20130101)
A61K 45/06 (20130101)
A61K 2039/545 (20130101)

Peptides
C07K 14/005 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277074 Schellenberger et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Amunix Pharmaceuticals (South San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) Volker Schellenberger (Palo Alto, California);  Joshua Silverman (Los Altos Hills, California);  Chia-wei Wang (Santa Clara, California);  Benjamin Spink (San Carlos, California);  Willem P. Stemmer (Los Gatos, California);  Nathan Geething (Natick, Massachusetts);  Wayne To (Fremont, California);  Jerrfey L. Cleland (San Carlos, California)
ABSTRACT The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
FILED Friday, January 15, 2021
APPL NO 17/150426
CURRENT CPC
Peptides
C07K 14/001 (20130101)
C07K 14/47 (20130101) Original (OR) Class
C07K 14/61 (20130101)
C07K 14/545 (20130101)
C07K 14/605 (20130101)
C07K 14/745 (20130101)
C07K 2319/31 (20130101)
C07K 2319/35 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/644 (20130101)
C12N 9/6437 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277083 Galipeau et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Emory University (Atlanta, Georgia);  Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Jacques Galipeau (Atlanta, Georgia);  Jiusheng Deng (Snellville, Georgia)
ABSTRACT In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-4 and uses related thereto, e.g., enhancing the immune system. Typically, the GM-CSF and IL-4 are connected by a linker. In certain embodiments, the disclosure relates to isolated nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such a nucleic acid.
FILED Tuesday, May 18, 2021
APPL NO 17/324030
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/14 (20130101)
A61K 38/00 (20130101)
A61K 38/193 (20130101)
A61K 38/2026 (20130101)
A61K 39/0011 (20130101)
A61K 39/39 (20130101)
A61K 47/42 (20130101)

Peptides
C07K 14/535 (20130101)
C07K 14/5406 (20130101) Original (OR) Class
C07K 2319/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/06 (20130101)
C12N 15/09 (20130101)
C12N 15/1024 (20130101)
C12N 15/1027 (20130101)
C12N 15/1062 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277092 Crowe, JR. et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S) Vanderbilt University (Nashville, Tennessee)
INVENTOR(S) James E. Crowe, JR. (Nashville, Tennessee);  Seth Zost (Nashville, Tennessee);  Robert Carnahan (Nashville, Tennessee);  Pavlo Gilchuk (Nashville, Tennessee)
ABSTRACT The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
FILED Thursday, February 11, 2021
APPL NO 17/173417
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 2039/545 (20130101)

Peptides
C07K 16/10 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/31 (20130101)
C07K 2317/565 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/563 (20130101)
G01N 33/56983 (20130101)
G01N 2333/165 (20130101)
G01N 2800/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277096 Rosenthal et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) Annexon Inc. (South San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) Arnon Rosenthal (Woodside, California);  Michael Leviten (Emerald Hills, California)
ABSTRACT The present invention provides anti-C1q antibodies and methods of using the same.
FILED Wednesday, February 10, 2021
APPL NO 17/172807
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0004 (20130101)
A61K 2039/505 (20130101)

Peptides
C07K 16/18 (20130101) Original (OR) Class
C07K 16/40 (20130101)
C07K 2317/33 (20130101)
C07K 2317/34 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56966 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277099 CHEN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
NIH Office of the Director (NIHOD)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Yvonne Yu-Hsuan CHEN (Los Angeles, California);  Zenan Li CHANG (Los Angeles, California)
ABSTRACT Aspects of the disclosure relate to polypeptides comprising a signal peptide, an antigen-binding domain that specifically binds TGF-β, a peptide spacer, a transmembrane domain, and an endodomain. When expressed in a cell, the polypeptides are capable of not only neutralizing the TGF-β but also specifically triggering T-cell activation in the presence of TGF-β. T-cell activation spurs the immune cell to produce immunostimulatory cytokines and proliferate, thus turning TGF-β from an immunosuppressive signal to an activating stimulus.
FILED Tuesday, May 18, 2021
APPL NO 17/323568
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/00 (20130101)
A61K 39/0008 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
A61P 37/02 (20180101)

Peptides
C07K 14/7051 (20130101)
C07K 16/22 (20130101) Original (OR) Class
C07K 2317/622 (20130101)
C07K 2319/02 (20130101)
C07K 2319/03 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0637 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/505 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277102 PANDOLFI
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (Boston, Massachusetts)
ASSIGNEE(S) BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (BOSTON, Massachusetts)
INVENTOR(S) PIER PAOLO PANDOLFI (BOSTON, Massachusetts)
ABSTRACT As described below, the present invention features compositions and methods of treating cancers characterized by the loss of Pten, Zbtb7a/Pokemon, p53, Pml and other tumor suppressors by inhibiting the expression or activity of CXCL17; and methods for identifying CXCL17 antagonists using a murine platform.
FILED Tuesday, August 29, 2017
APPL NO 16/328631
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0271 (20130101)
A01K 2207/12 (20130101)
A01K 2227/105 (20130101)
A01K 2267/0331 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/415 (20130101)
A61K 31/426 (20130101)
A61K 31/713 (20130101)
A61K 31/7105 (20130101)

Peptides
C07K 16/24 (20130101) Original (OR) Class

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5088 (20130101)
G01N 33/57434 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277108 SHUSTA et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Eric V. SHUSTA (Madison, Wisconsin);  Charles C. STUTZ (Waltham, Massachusetts)
ABSTRACT The present invention provides antibodies or antigen binding fragments thereof including single chain variable fragment (scFv) antibodies that specifically bind to the blood brain barrier in vivo and methods of use.
FILED Wednesday, July 24, 2019
APPL NO 17/260697
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6803 (20170801)

Peptides
C07K 16/28 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/565 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277125 Nishimura et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Stephen L. Nishimura (San Francisco, California);  Anthony Cormier (San Francisco, California);  Saburo Ito (San Francisco, California);  Jianlong Lou (San Francisco, California);  James D. Marks (San Francisco, California);  Yifan Cheng (San Francisco, California);  Melody G. Campbell (San Francisco, California);  Jody L. Baron (San Francisco, California)
ABSTRACT Antibodies that bind to αv⊖8 are provided.
FILED Friday, January 15, 2021
APPL NO 17/151009
CURRENT CPC
Peptides
C07K 16/2839 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/565 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277140 VALE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Ronald D. VALE (Tiburon, California);  Meghan A. MORRISSEY (San Francisco, California);  Adam P. WILLIAMSON (Berkeley, California)
ABSTRACT The present disclosure generally relate to novel chimeric antigen receptors (CARs) that bind an engulfment receptor expressed on the surface of a phagocytic cell and activate the endogenous phagocytic signaling pathway. Also disclosed are compositions and methods useful for producing such CARs, nucleic acids encoding same, phagocytic cells that have been modified to include a targeted effector activity directed towards a cell of interest such as, e.g., a cancer cell, as well as for modifying a cell and/or for the treatment of various health disorders such as cancer, including solid tumor and hematologic malignancy.
FILED Tuesday, May 11, 2021
APPL NO 17/317138
CURRENT CPC
Peptides
C07K 14/4748 (20130101)
C07K 16/30 (20130101) Original (OR) Class
C07K 2317/622 (20130101)
C07K 2319/03 (20130101)
C07K 2319/09 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277356 Riley et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S) James L. Riley (Downingtown, Pennsylvania);  Daniel H. Fowler (Bethesda, Maryland);  Shoba Amarnath (Washington, District of Columbia)
ABSTRACT The present invention provides methods and compositions for converting a T cell into a cell that exhibits at least one regulatory T cell phenotype. The converted T cell is generated by contacting a T cell with a cell that is modified to comprise an agent capable of activating PD1 signaling in a T cell. The converted T cell is useful for preventing, suppressing, blocking or inhibiting an immune response. For example the converted T cell is useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft versus host disease. The converted T cell can also be used to treat autoimmune diseases.
FILED Monday, October 19, 2020
APPL NO 17/074200
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0637 (20130101) Original (OR) Class
C12N 2501/998 (20130101)
C12N 2502/99 (20130101)
C12N 2506/11 (20130101)
C12N 2506/115 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277357 Slepian et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Naing BIJAJ (Tucson, Arizona);  Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona);  The Research Foundation for the State University of New York (Albany, New York)
ASSIGNEE(S)
INVENTOR(S) Marvin J. Slepian (Tucson, Arizona);  Yana Roka-Moiia (Tucson, Arizona);  Danny Bluestein (Stony Brook, New York);  Naing Bijaj (Tucson, Arizona);  Michael Dicaro (Tucson, Arizona);  Louise Hecker (Tucson, Arizona)
ABSTRACT Biochemical markers that can be measured to determine the level of mechanical activation of a population of platelets are provided, and their use to prepare molecular signatures thereof are provided. The markers include phosphatidylserine, thrombin, integrin GPIIb/IIIa activation, glycoprotein GP Ib, P-selectin; platelet size; microparticle generation, or lipidomic profile of the membrane. The disclosed markers, measurement thereof, and signatures composed therefrom can be used in a variety of methods of patient selection, treatment monitoring, treatment selection, including both devices and active agents, and methods of treating subjects in need thereof, particularly humans. Examples of such methods include, but are not limited to, reducing shear-activated platelets; selecting a blood-contacting medical device; selecting between two or more medical devices; identifying a subject at a risk of developing a thrombogenic event; monitoring the prophylactic treatment of a subject; selecting a mechanoceutical agent; and delivering an agent to a subject.
FILED Monday, June 17, 2019
APPL NO 17/252577
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/19 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0644 (20130101) Original (OR) Class
C12N 13/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/68 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277360 Nguyen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Kansas State University Research Foundation (Manhattan, Kansas);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S) Thu Annelise Nguyen (Amarillo, Texas);  Ralph E. Parchment (Frederick, Maryland);  Robert J. Kinders (Walkersville, Maryland)
ABSTRACT A three-dimensional heterogenous cell spheroid comprising a plurality of at least two different types of cells and one or more short peptide cell linkers. The peptide cell linkers are linear peptides having respective terminal ends, and comprising an adhesion sequence at or near each end, with a suitable spacer sequence between each adhesion sequence. Methods of making and using such spheroids for in vitro testing are also described.
FILED Monday, July 15, 2019
APPL NO 17/260365
CURRENT CPC
Peptides
C07K 5/0817 (20130101)
C07K 7/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0062 (20130101)
C12N 5/0693 (20130101)
C12N 5/0697 (20130101) Original (OR) Class
C12N 15/1093 (20130101)
C12N 2502/28 (20130101)
C12N 2502/30 (20130101)
C12N 2513/00 (20130101)
C12N 2533/50 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5011 (20130101)
G01N 33/5088 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277364 Lock et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Martin Lock (Southampton, Pennsylvania);  Mauricio Alvira (Philadelphia, Pennsylvania)
ABSTRACT A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.
FILED Monday, May 24, 2021
APPL NO 17/328686
CURRENT CPC
Separation
B01D 15/3804 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/281 (20130101)
B01J 41/05 (20170101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 7/02 (20130101) Original (OR) Class
C12N 15/8645 (20130101)
C12N 2750/14143 (20130101)
C12N 2750/14151 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/33 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277370 Davidson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  University of Iowa Research Foundation (Iowa City, Iowa)
ASSIGNEE(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  University of Iowa Research Foundation (Iowa City, Iowa)
INVENTOR(S) Beverly Davidson (Iowa City, Iowa);  Chie-Yu Lin (Cambridge, Massachusetts);  Edgardo Rodriguez (Iowa City, Iowa);  Feng Zhang (Cambridge, Massachusetts)
ABSTRACT The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences especially for use as to nucleotide repeat disorders. Provided are delivery systems and tissues or organ which are targeted as sites for delivery especially for use as to nucleotide repeat disorders. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex or system especially for use as to nucleotide repeat disorders, as well as methods for the design and of such. Also provided are methods of directing CRISPR complex or system formation in eukaryotic cells especially for use as to nucleotide repeat disorders including with consideration of specificity for target recognition and avoidance of toxicity and editing or modifying a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
FILED Tuesday, December 01, 2020
APPL NO 17/108771
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0276 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101)
A61K 38/465 (20130101)
A61K 48/005 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 9/22 (20130101) Original (OR) Class
C12N 15/63 (20130101)
C12N 15/86 (20130101)
C12N 15/102 (20130101)
C12N 15/113 (20130101)
C12N 15/907 (20130101)
C12N 15/1082 (20130101)

Enzymes
C12Y 301/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277371 RAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Fei RAN (Cambridge, Massachusetts);  Feng ZHANG (Cambridge, Massachusetts)
ABSTRACT The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures to be used in optimized CRISPR-Cas enzyme systems.
FILED Wednesday, December 16, 2020
APPL NO 17/123918
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101) Original (OR) Class
C12N 15/63 (20130101)
C12N 15/113 (20130101)
C12N 15/115 (20130101)
C12N 15/907 (20130101)
C12N 2310/10 (20130101)
C12N 2310/16 (20130101)
C12N 2310/20 (20170501)
C12N 2310/3519 (20130101)

Enzymes
C12Y 301/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277378 SCHELLENBERGER et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) BIOVERATIV THERAPEUTICS INC. (Waltham, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Volker SCHELLENBERGER (Palo Alto, California);  Willem P. STEMMER (Los Gatos, California);  Nathan C. GEETHING (Santa Clara, California);  Wayne TO (Fremont, California);  Joshua SILVERMAN (Sunnyvale, California);  Chia-wei WANG (Milpitas, California);  Benjamin SPINK (San Carlos, California)
ABSTRACT The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
FILED Tuesday, January 19, 2021
APPL NO 17/152239
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/001 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/644 (20130101) Original (OR) Class
C12N 9/6437 (20130101)

Enzymes
C12Y 304/21022 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277384 JOHNSTON
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) THE FORSYTH INSTITUTE (Cambridge, Massachusetts)
ASSIGNEE(S) FRED HUTCHINSON CANCER RESEARCH CENTER (SEATTLE, Washington)
INVENTOR(S) CHRISTOPHER D. JOHNSTON (SEATTLE, Washington)
ABSTRACT The present invention features modified polynucleotide sequences that mimic host cell DNA and methods of using such sequences for the genetic engineering of bacteria that are otherwise genetically intractable.
FILED Friday, October 13, 2017
APPL NO 16/341290
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/102 (20130101) Original (OR) Class

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101)
C12Q 2600/154 (20130101)
C12Q 2600/156 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277387 O'Farrell et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) Altratech Limited (Limerick, Ireland);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Rockville, Maryland)
ASSIGNEE(S)
INVENTOR(S) Brian O'Farrell (Watergrasshill, Ireland);  Claire O'Connell (Stamullen, Ireland);  Kaylyn Oshaben (Summerhill, Pennsylvania);  Daniel Appella (Bethesda, Maryland)
ABSTRACT A method of target enrichment or depletion from a sample with an analyte is described. A probe has one of a left-handed PNA pair and a targeting moiety, in which the left-handed PNA pair are a complementary pair of PNAs that are chiral and have a cyclic backbone modification that induces a left-handed helical structure. A capture surface has the other of the left-handed PNA pair; and the left-handed PNA pair bind to hybridize the probe to the capture surface, which may be a magnetic bead.
FILED Friday, March 05, 2021
APPL NO 17/193652
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1013 (20130101) Original (OR) Class

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277395 Maher et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Christopher Maher (St. Louis, Missouri);  Jessica Silva-Fisher (St. Louis, Missouri);  Ryan Fields (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Christopher Maher (St. Louis, Missouri);  Jessica Silva-Fisher (St. Louis, Missouri);  Ryan Fields (St. Louis, Missouri)
ABSTRACT Among the various aspects of the present disclosure is the provision of a methods and compositions for modulating IncRNAs and methods of treatment based on IncRNA expression.
FILED Tuesday, January 26, 2021
APPL NO 17/158845
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/102 (20130101)
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2320/30 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101)
C12Q 2600/106 (20130101)
C12Q 2600/178 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277399 Ayele et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Emory University (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Tewoderos Ayele (Atlanta, Georgia);  Jennifer Heemstra (Atlanta, Georgia)
ABSTRACT This disclosure relates to methods of imaging and tracking RNA or other nucleic acids in cells. In certain embodiments, this disclosure relates to methods of labeling intracellular nucleic acids by expressing in the cell RNA containing an aptamer sequence that specifically binds a label, e.g., fluorescent label, or placing in the cell nucleic acids containing an aptamer sequence that specifically binds a label, wherein the label comprises a carbene forming group, such as a diazirine group, under conditions such that the label specifically binds the aptamer sequence forming a complex; and exposing the complex to electromagnetic radiation sufficient for carbene formation resulting in a covalent bond to the aptamer sequence and the label.
FILED Wednesday, February 10, 2021
APPL NO 17/172480
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/115 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2310/14 (20130101)
C12N 2310/16 (20130101)
C12N 2310/3513 (20130101)
C12N 2310/3519 (20130101)
C12N 2320/32 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277402 Messina et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Louis M. Messina (Westborough, Massachusetts);  Guodong Tie (Shrewsbury, Massachusetts)
ABSTRACT Methods and compositions for treating cancer, e.g., colorectal cancer, using a miR-101-3p inhibitor.
FILED Tuesday, October 31, 2017
APPL NO 16/332588
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/28 (20130101)
A61K 45/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1137 (20130101) Original (OR) Class
C12N 2310/141 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277410 DELLAPORTA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Research Resources (NCRR)
National Science Foundation (NSF)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut);  RHODE ISLAND COUNCIL ON POSTSECONDARY EDUCATION (Warwick, Rhode Island)
ASSIGNEE(S)
INVENTOR(S) Stephen L. DELLAPORTA (Branford, Connecticut);  Andrew HAYWARD (Madison, Connecticut);  Maria MORENO (Branford, Connecticut);  Albert KAUSCH (Stonington, Connecticut);  John MOTTINGER (North Kingstown, Rhode Island)
ABSTRACT The present invention pertains to genetically modified plants, particularly maize, sorghum and rice, with an all pistillate or all staminate phenotype and methods of the same. The survival of functional pistils in maize requires the action of the sk1 gene. SK1 encodes a glycosyltransferase (GT) that protects pistils from tasselseed-mediated cell death. sk1-dependent pistil protection at a developing floret gives rise to stamen arrest at the same floret, and so determines the pistillate floral fate. This is the first single gain-of-function gene known to control sexuality. The present invention further provides a direct strategy to extend hybrid technologies to related cereals such as sorghum and rice. Tasselseed and silkless genes represent major sex determination genes in maize, a pathway that permits the efficient production of hybrid seed and the associated benefits of heterosis-increased yield, resistance to pathogens, etc. Except for maize, current hybrid systems in cereals are fraught with genetic and environmental limitations. Genotype-independent hybrid cereal technology could potentially increase crop yields as much as 20-40% without placing additional land under agricultural production. This has profound implications for food security and the environmental impact of agriculture in some of the poorest regions of the world.
FILED Friday, August 11, 2017
APPL NO 16/326490
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/829 (20130101)
C12N 15/8212 (20130101)
C12N 15/8213 (20130101)
C12N 15/8216 (20130101) Original (OR) Class
C12N 15/8289 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277419 Barzel et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Adi Barzel (Palo Alto, California);  Mark A. Kay (Los Altos, California)
ABSTRACT Methods and compositions are provided for editing the genome of a cell without the use of an exogenously supplied nuclease. Aspects of the methods include contacting a cell with a targeting vector comprising nucleic acid sequence to be integrated into the target locus, where the cell is not also contacted with a nuclease. In addition, reagents, devices and kits thereof that find use in practicing the subject methods are provided.
FILED Monday, May 17, 2021
APPL NO 17/322561
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/1866 (20130101)
A61K 48/005 (20130101)
A61K 48/0008 (20130101)

Peptides
C07K 16/1045 (20130101)
C07K 2317/76 (20130101)
C07K 2319/92 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/644 (20130101)
C12N 15/52 (20130101)
C12N 15/86 (20130101) Original (OR) Class
C12N 15/907 (20130101)
C12N 2750/14143 (20130101)
C12N 2799/025 (20130101)
C12N 2800/24 (20130101)
C12N 2840/20 (20130101)

Enzymes
C12Y 304/21022 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277421 Hopkins et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) NemaMetrix, Inc (Eugene, Oregon)
ASSIGNEE(S) NemaMetrix, Inc (Eugene, Oregon)
INVENTOR(S) Christopher E. Hopkins (Murray, Utah);  Trisha Brock (Eugene, Oregon);  Thomas Marshall (Eugene, Oregon);  Mary Colasanto (Eugene, Oregon);  Zachary Stevenson (Eugene, Oregon)
ABSTRACT The present disclosure provides homologous recombination reporter nucleic acid construct reagents for increasing the likelihood of detecting successful modification of a specific sequence in chromosomal DNA of a host cell via homologous recombination. The homologous recombination reporter constructs contain a sequence element inserted within the coding sequence for a reporter gene resulting in a mutated reporter gene. The sequence element is removed via homologous recombination based on the presence of two homology regions present in the reporter construct.
FILED Tuesday, August 06, 2019
APPL NO 17/266592
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/113 (20130101)
C12N 15/902 (20130101) Original (OR) Class
C12N 15/8212 (20130101)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277423 Musunuru et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts);  The Children's Medical Center Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Kiran Musunuru (Cambridge, Massachusetts);  Chad A. Cowan (Boston, Massachusetts);  Derrick J. Rossi (Newton, Massachusetts)
ABSTRACT Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells for treating or preventing genetic blood disorders.
FILED Friday, May 21, 2021
APPL NO 17/327625
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/465 (20130101)
A61K 48/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/907 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277449 Quake et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
NIH Office of the Director (NIHOD)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Stephen R. Quake (Stanford, California);  Thomas M. Snyder (Palo Alto, California);  Hannah Valantine (Stanford, California)
ABSTRACT The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.
FILED Tuesday, May 18, 2021
APPL NO 17/323917
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101) Original (OR) Class
C12Q 1/6837 (20130101)
C12Q 1/6869 (20130101)
C12Q 1/6883 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/00 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277450 Rasmussen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) BioFire Diagnostics, LLC (Salt Lake City, Utah)
ASSIGNEE(S)
INVENTOR(S) Randy P. Rasmussen (Salt Lake City, Utah);  Robert John Crisp (Salt Lake City, Utah);  Andrew Clinton Hemmert (Murray, Utah);  Elizabeth Barker Campbell (Orem, Utah);  Thomas Charles Robbins (Salt Lake City, Utah);  David J. Eyre (Salt Lake City, Utah)
ABSTRACT Methods and devices are provided for simultaneously amplifying a plurality of sample wells for a predetermined amount of amplification, detecting whether amplification has occurred in a first set of the wells, amplifying for an additional amount of amplification and detecting whether amplification has occurred in a second set of the wells. Methods are also provided for analyzing a target nucleic acid sequence using melt curves that were generated in a plurality of amplification cycles.
FILED Tuesday, May 25, 2021
APPL NO 17/329844
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101) Original (OR) Class
C12Q 1/689 (20130101)
C12Q 1/705 (20130101)
C12Q 1/6851 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277454 Dhara et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Trustees of Dartmouth College (Hanover, New Hampshire);  Memorial Sloan Kettering Cancer Center (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Surajit Dhara (Hanover, New Hampshire);  Steven D. Leach (Hanover, New Hampshire);  Sagar Chhangawala (New York, New York);  Christina Leslie (New York, New York)
ABSTRACT The present disclosure relates to an array-based assay for transposase-accessible chromatin and prognostic molecular markers of treatment-resistant/early recurrent cancer. The present disclosure also relates to predicting an outcome, such as duration of disease-free survival, in a cancer patient.
FILED Tuesday, May 18, 2021
APPL NO 17/324093
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1093 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6837 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57438 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277455 SARKAR et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Saheli SARKAR (Boston, Massachusetts);  Tania KONRY (Boston, Massachusetts)
ABSTRACT The invention provides a device, method, and system for high throughput detection of nucleic acid expression in individual cells. Cells are encapsulated in aqueous microdroplets which are merged with a biocompatible matrix, allowing on-chip fluorescence in situ hybridization on both adherent and non-adherent cells. The invention also provides multiplexed detection of nucleic acids, proteins, and cellular activity. The device and methods can be used to assess cellular interactions and to test the effects of antitumor agents.
FILED Wednesday, July 12, 2017
APPL NO 16/317308
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502784 (20130101)
B01L 2200/0668 (20130101)
B01L 2300/069 (20130101)
B01L 2300/087 (20130101)
B01L 2300/0816 (20130101)
B01L 2300/0819 (20130101)
B01L 2300/0867 (20130101)
B01L 2300/0883 (20130101)
B01L 2400/0487 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6841 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6458 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277459 Gormley et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) Illumina Cambridge Limited (Cambridge, United Kingdom);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Niall Gormley (Essex, United Kingdom);  Andreas Gnirke (Cambridge, Massachusetts);  David Jaffe (Cambridge, Massachusetts);  Harris Nusbaum (Cambridge, Massachusetts)
ABSTRACT The invention relates to a method of preparing and using a library of template polynucleotides suitable for use as templates in solid-phase nucleic acid amplification and sequencing reactions to determine the methylation status of the cytosine bases in the library. In particular, the invention relates to a method of preparing and analysing a library of template polynucleotides suitable for methylation analysis.
FILED Wednesday, February 17, 2021
APPL NO 17/178125
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6809 (20130101)
C12Q 1/6827 (20130101)
C12Q 1/6855 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277466 Xie et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Xiaoliang Sunney Xie (Lexington, Massachusetts);  Katsuyuki Shiroguchi (Arlington, Massachusetts);  Peter A. Sims (Cambridge, Massachusetts);  Tony Z. Jia (Cambridge, Massachusetts)
ABSTRACT Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
FILED Friday, May 14, 2021
APPL NO 17/320361
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1065 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6853 (20130101)
C12Q 1/6874 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277467 Vogelstein et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Bert Vogelstein (Baltimore, Maryland);  Kenneth W. Kinzler (Baltimore, Maryland);  Nickolas Papadopoulos (Towson, Maryland);  Isaac A. Kinde (Beaumont, California)
ABSTRACT The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ≥95% of them contain the identical mutation. We illustrate the utility of this approach for determining the fidelity of a polymerase, the accuracy of oligonucleotides synthesized in vitro, and the prevalence of mutations in the nuclear and mitochondrial genomes of normal cells.
FILED Wednesday, May 19, 2021
APPL NO 17/324253
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101)
C12Q 1/6869 (20130101)
C12Q 1/6874 (20130101) Original (OR) Class
C12Q 1/6876 (20130101)
C12Q 2525/179 (20130101)
C12Q 2525/191 (20130101)
C12Q 2563/179 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277468 Vogelstein et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Bert Vogelstein (Baltimore, Maryland);  Kenneth W. Kinzler (Baltimore, Maryland);  Nickolas Papadopoulos (Towson, Maryland);  Isaac A. Kinde (Beaumont, California)
ABSTRACT The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ≥95% of them contain the identical mutation. We illustrate the utility of this approach for determining the fidelity of a polymerase, the accuracy of oligonucleotides synthesized in vitro, and the prevalence of mutations in the nuclear and mitochondrial genomes of normal cells.
FILED Wednesday, May 19, 2021
APPL NO 17/324380
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101)
C12Q 1/6869 (20130101)
C12Q 1/6874 (20130101) Original (OR) Class
C12Q 1/6876 (20130101)
C12Q 2525/179 (20130101)
C12Q 2525/191 (20130101)
C12Q 2563/179 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277470 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
IDeA Networks of Biomedical Research Excellence (INBRE)
APPLICANT(S) University of Alaska Fairbanks (Fairbanks, Alaska)
ASSIGNEE(S)
INVENTOR(S) Jiguo Chen (Fairbanks, Alaska);  Fang Ge (Fairbanks, Alaska)
ABSTRACT Disclosed are compositions and methods for enriching a non-host sequence from a host sample. Also disclosed are compositions and methods for detecting a non-host sequence in a host sample. For example, a pathogen can be enriched and detected in a sample taken from a human without knowing what the pathogen is.
FILED Tuesday, May 25, 2021
APPL NO 17/330338
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1003 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101)
C12Q 1/6874 (20130101) Original (OR) Class
C12Q 1/6888 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277476 Lewis et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Nathan Lewis (La Jolla, California);  Tiziano Pramparo (La Jolla, California);  Eric Courchesne (La Jolla, California);  Vahid Hajihoseini Gazestani (La Jolla, California)
ABSTRACT The invention provides for the detection of a perturbed gene network, which includes highly expressed genes during fetal brain development, which is dysregulated in neuron models of autism spectrum disorder (ASD). High-confidence ASD risk genes are upstream regulators of the network modulating RAS/ERK, PI3K/AKT, and WNT//β-catenin signaling pathways. The invention demonstrates how the heterogeneous genetics of ASD can dysregulate a core network to influence brain development at prenatal and very early postnatal ages and, thereby, the severity of later ASD symptoms. The invention provides a model for diagnosis, prognosis determination, and optionally treatment and monitoring, for any disease by comparing molecular marker patterns in non-affected tissues in a subject with healthy controls to determine a dysregulated network in the subject based on a co-expression pattern of interacting genes.
FILED Friday, July 12, 2019
APPL NO 17/257806
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278328 Schuck et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
ASSIGNEE(S) THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
INVENTOR(S) Peter W. Schuck (Bethesda, Maryland);  John W. Kakareka (Bethesda, Maryland);  Thomas J. Pohida (Bethesda, Maryland);  George Patterson (Bethesda, Maryland);  Hauying Zhao (Bethesda, Maryland)
ABSTRACT The present disclosure provides various embodiments of a fluorescence scanning system having a sample holder with a sample suspended within that is rotated by a centrifuge such that the sample is illuminated at various angles by an excitation beam by operation of a galvanometer and such that the sample emits a fluorescence emissions that is detected through a narrow window of exposure defined along the travel path of rotation taken by the sample holder when rotated by the centrifuge. A stationary fluorescence detector is in operative communication with the sample holder along the narrow window of exposure for detecting the fluorescence emissions emitted by the sample from the sample holder while also separating the excitation beam from the fluorescence emissions.
FILED Thursday, March 04, 2021
APPL NO 17/192623
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/4077 (20130101) Original (OR) Class
G01N 21/645 (20130101)
G01N 2021/6478 (20130101)
G01N 2201/0636 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278332 Vacca et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Kinetic River Corp. (Mountain View, California)
ASSIGNEE(S)
INVENTOR(S) Giacomo Vacca (Campbell, California);  Ralph Jimenez (Boulder, Colorado)
ABSTRACT Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.
FILED Friday, May 21, 2021
APPL NO 17/326662
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/14 (20130101) Original (OR) Class
G01N 15/147 (20130101)
G01N 15/1429 (20130101)
G01N 15/1434 (20130101)
G01N 2015/1006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278367 Herr et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Child Health and Human Development (NICHD)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Amy E. Herr (Berkeley, California);  Lin He (Berkeley, California);  Andrew J. Modzelewski (Berkeley, California);  Elisabet Rosàs-Canyelles (Berkeley, California)
ABSTRACT Dual nucleic acid and protein isoform measurements are performed on low starting cell numbers (e.g. equivalent to the number of blastomeres composing early embryonic development stages (morula and blastocysts)), comprising integrating fractionation polyacrylamide gel electrophoresis (fPAGE) of 10-100 cells with off-chip analysis of nucleic acids in the nuclei.
FILED Monday, May 24, 2021
APPL NO 17/327806
CURRENT CPC
Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 9/40 (20130101)
C08J 2333/26 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 5/1545 (20130101)

Compositions of Macromolecular Compounds
C08L 33/26 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/44747 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278380 Wu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Board of Regents of the University of Oklahoma (Oklahoma City, Oklahoma)
ASSIGNEE(S) The Board of Regents of the University of Oklahoma (Oklahoma City, Oklahoma)
INVENTOR(S) Si Wu (Norman, Oklahoma);  Lushuang Huang (Norman, Oklahoma);  Zhe Wang (San Francisco, California)
ABSTRACT A spray-capillary device is configured to process ultra low-volume samples. The spray-capillary device includes a spray capillary that includes an inlet end and a discharge end. The spray capillary includes a porous section at the discharge end. A downstream connector provides an interface between the porous section of the spray capillary, a conductive fluid, and a high voltage electrical source. The application of voltage to the downstream connector causes electrospray ionization, which can be used to draw ultra law volume samples into the inlet end. A gas injection assembly can be used to increase the pressure on the inlet end of the spray capillary to encourage movement of the sample through the spray capillary. The spray-capillary device is well suited for providing ultra low samples to a mass spectrometer detection device.
FILED Monday, March 08, 2021
APPL NO 17/194539
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 30/7266 (20130101) Original (OR) Class

Electric Discharge Tubes or Discharge Lamps
H01J 49/167 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278384 Potyrailo et al.
FUNDED BY
Department of Health and Human Services (HHS)
Centers for Disease Control and Prevention (CDC)
National Institute for Occupational Safety and Health (NIOSH)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) Radislav Alexandrovich Potyrailo (Niskayuna, New York);  Richard St. Pierre (Clifton Park, New York);  Bruce Courtney Amm (Clifton Park, New York)
ABSTRACT A multi-gas sensing system includes a sensing circuit comprising one or more sensing elements. Each sensing element includes a sensing material configured to detect at least one gas analyte. A management circuit is configured to excite the sensing elements with an alternating current at at least one predetermined frequency. The management circuit measures one or more electrical responses of the sensing elements responsive to exciting the sensing elements with the alternating current. The management circuit determines one or more characteristics of the sensing circuit. One or more processors receive the electrical responses of the sensing elements and the characteristics of the sensing circuit. The one or more processors determine a concentration of the at least one gas analyte based on the electrical responses of the sensing elements and the characteristics of the sensing circuit.
FILED Monday, March 09, 2020
APPL NO 16/812613
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/0006 (20130101)
G01N 33/0031 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278391 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Yibin Wang (Encino, California);  Haipeng Sun (Los Angeles, California)
ABSTRACT The present application provides a method of assessing metabolic competence and treating metabolic disorders, including cardiovascular disease, obesity, and diabetes.
FILED Thursday, February 01, 2018
APPL NO 16/482977
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/381 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/00 (20180101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/4833 (20130101) Original (OR) Class
G01N 2560/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278392 Branton et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Daniel Branton (Lexington, Massachusetts);  Stephen Jordan Fleming (Cincinnati, Ohio);  Jene A. Golovchenko (Lexington, Massachusetts)
ABSTRACT A nanopore system provided herein includes first and second fluidic reservoirs in fluidic communication with a nanopore forming a fluidic path between the reservoirs. An enzyme clamp, provided in the first fluidic reservoir, abuts the nanopore and is reversibly bound to a sequential plurality of polymer subunits of a target polymer molecule in ionic solution. The clamp has an outer clamp diameter that is greater than the nanopore diameter. An electrical circuit includes an electrode in each of the reservoirs for applying a voltage bias across the nanopore. A pulse generator is connected in the electrical circuit to apply control pulses across the nanopore to step the clamp along sequential polymer subunits of the target polymer molecule. The system includes no fuel or source of fuel for the clamp. A controller is connected in the electrical circuit for controlling the collection of electrical indications of polymer subunits.
FILED Thursday, May 13, 2021
APPL NO 17/319254
CURRENT CPC
Separation
B01D 71/021 (20130101)
B01D 71/74 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 35/00 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6869 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/40 (20130101)
G01N 33/48721 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278393 REED et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia)
ASSIGNEE(S) Virginia Commonwealth University (Richmond, Virginia)
INVENTOR(S) Jason REED (Richmond, Virginia);  Amir TOOR (Richmond, Virginia);  Kevin LESLIE (Richmond, Virginia)
ABSTRACT Provided herein are methods of determining the mass of T cells in stem cell transplant (SCT) recipients at risk of developing graft vs host disease (GVHD), and tumor (e.g. melanoma) cells in patients at risk of developing drug resistant tumors, using Live-Cell Interferometry (LCI) so that treatment may be appropriately modulated. High Speed LCI (HSLCI) apparatuses to conduct the cell mass measurements are also provided.
FILED Tuesday, September 19, 2017
APPL NO 16/330554
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/45 (20130101)
G01N 33/505 (20130101) Original (OR) Class
G01N 33/5011 (20130101)
G01N 2201/08 (20130101)
G01N 2201/06113 (20130101)
G01N 2800/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278401 Wei et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Wei Wei (Seattle, Washington);  Min Xue (Chino Hills, California);  Zhonghan Li (Portland, Oregon);  Hanjun Cheng (Seattle, Washington)
ABSTRACT In various embodiments an analytical method for profiling lactate (or other analyte) production in single cells, via the use of coupled enzyme reactions on surface-grafted resazurin/resofurin molecules is provided. Additionally surface-bound resazurin/resofurin that retains redox indicator activity as well as microfluidic devices comprising such sur-face-bound resazurin/resofurin indicators are provided.
FILED Monday, July 08, 2019
APPL NO 17/258427
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502761 (20130101)
B01L 2200/16 (20130101)
B01L 2300/123 (20130101)
B01L 2300/0636 (20130101)
B01L 2300/0819 (20130101)
B01L 2300/0829 (20130101)
B01L 2300/0867 (20130101)
B01L 2300/0893 (20130101)

Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 62/78 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/07 (20130101)
C09K 2211/1018 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/26 (20130101)
C12Q 1/32 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/54353 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278415 Moller
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) David R. Moller (Elicott City, Maryland)
ASSIGNEE(S)
INVENTOR(S) David R. Moller (Elicott City, Maryland)
ABSTRACT Sarcoidosis is a multisystem disease characterized by granulomatous inflammation in affected organs. The present invention discloses kits and a system for a blood test using mycobacterial catalase-peroxidase that has a high positive predictive value for confirming a diagnosis of sarcoidosis.
FILED Thursday, May 13, 2021
APPL NO 17/319211
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/28 (20130101)
C12Q 1/30 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6866 (20130101) Original (OR) Class
G01N 33/6893 (20130101)
G01N 2333/57 (20130101)
G01N 2800/24 (20130101)
G01N 2800/7095 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278416 ANANTHAKRISHNAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts);  THE GENERAL HOSPITAL CORPORATION (BOSTON, Massachusetts)
ASSIGNEE(S) THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts);  THE GENERAL HOSPITAL CORPORATION (BOSTON, Massachusetts)
INVENTOR(S) ASHWIN N. ANANTHAKRISHNAN (BOSTON, Massachusetts);  CHENGWEI LUO (CAMBRIDGE, Massachusetts);  VIJAY YAJNIK (BOSTON, Massachusetts);  RAMNIK J. XAVIER (BOSTON, Massachusetts)
ABSTRACT The present invention relates to a relationship between microbial metagenomic structure and function and clinical remission with anti-integrin therapy induction; longitudinal trajectory of changes in the microbiome with maintenance treatment; and a comprehensive predictive model incorporating clinical and microbiome-related data to accurately classify treatment response.
FILED Wednesday, May 09, 2018
APPL NO 16/612141
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6893 (20130101) Original (OR) Class
G01N 2800/52 (20130101)
G01N 2800/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278417 M'Koma et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
National Institute on Drug Abuse (NIDA)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute on Minority Health and Health Disparities (NIMHD)
APPLICANT(S) Meharry Medical College (Nashville, Tennessee)
ASSIGNEE(S) Meharry Medical College (Nashville, Tennessee)
INVENTOR(S) Amosy E. M'Koma (Nashville, Tennessee);  Amos M. Sakwe (Nashville, Tennessee)
ABSTRACT A targeted DEFA5 antibody is disclosed herein. The targeted DEFA5 antibody has a high degree of specificity with DEFA5 protein, particularly with peptide sequences of the P, B, and/or M binding sites of the DEFA5 protein. The targeted DEFA5 antibody may be incorporated into an assay for diagnosing and treating ulcerative colitis and Crohns disease in a subject suffering from inflammatory bowel disease. The assay may be provided in a kit. The targeted DEFA5 antibody may be used in a method for measuring the level of DEFA5 or DEFA5 expression in a sample collected from a subject, and determining, based on the level of DEFA5 or DEFA5 expression, whether the subject is suffering from ulcerative colitis or Crohns disease. A treatment may be based on the determination of whether the subject has ulcerative colitis or Crohns disease.
FILED Wednesday, June 20, 2018
APPL NO 16/622259
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101)
C12Q 2600/106 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6893 (20130101) Original (OR) Class
G01N 2333/4721 (20130101)
G01N 2800/52 (20130101)
G01N 2800/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278418 CHATILA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE CHIDLREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
ASSIGNEE(S) THE CHIDLREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts)
INVENTOR(S) Talal Amine CHATILA (Belmont, Massachusetts);  Hani HARB (Brookline, Massachusetts);  Mingcan XIA (Boston, Massachusetts);  Amir MASSOUD (Tehran, Iran)
ABSTRACT Described herein are methods and compositions for treating asthma or an allergic disease. Aspects of the invention relate to administering to a subject an agent that targets Notch4. In one embodiment, the agent is an anti-Notch4 antibody.
FILED Friday, March 15, 2019
APPL NO 16/979382
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101)
A61K 31/7105 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6893 (20130101) Original (OR) Class
G01N 2800/24 (20130101)
G01N 2800/52 (20130101)
G01N 2800/122 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278655 Wilson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) David L. Wilson (Cleveland Heights, Ohio);  Naomi Joseph (Cleveland, Ohio);  Jonathan H. Lass (Cleveland, Ohio);  Beth Ann Benetz (Cleveland, Ohio);  Harry J. Menegay (Cleveland, Ohio);  Elizabeth Fitzpatrick (Nashville, Tennessee)
ABSTRACT Embodiments discussed herein facilitate automated and/or semi-automated segmentation of endothelial cells via a trained deep learning model. One example embodiment is a method, comprising: accessing an optical microscopy image comprising a set of corneal endothelial cells of a patient of a keratoplasty; pre-processing the optical microscopy image to generate a pre-processed optical microscopy image via correcting for at least one of shading or illumination artifacts in the optical microscopy image; segmenting, based at least in part on a trained deep learning (DL) model, a plurality of corneal endothelial cells of the set of corneal endothelial cells in the pre-processed optical microscopy image; and displaying, via a graphical user interface (GUI), at least the segmented plurality of corneal endothelial cells.
FILED Tuesday, January 05, 2021
APPL NO 17/141564
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0621 (20130101)

Optical Elements, Systems, or Apparatus
G02B 21/367 (20130101) Original (OR) Class

Image Data Processing or Generation, in General
G06T 7/10 (20170101)
G06T 2207/30024 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278656 Simpson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Garth Jason Simpson (West Lafayette, Indiana);  James Ulcickas (West Lafayette, Indiana);  Fengyuan Deng (Watertown, Massachusetts);  Changqin Ding (West Lafayette, Indiana)
ABSTRACT A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a micro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.
FILED Tuesday, May 18, 2021
APPL NO 17/322903
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/21 (20130101)

Optical Elements, Systems, or Apparatus
G02B 21/06 (20130101)
G02B 21/26 (20130101)
G02B 21/367 (20130101) Original (OR) Class

Image Data Processing or Generation, in General
G06T 5/005 (20130101)
G06T 2207/10056 (20130101)
G06T 2207/20212 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279864 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio);  Louis Stokes Cleveland Veterans Administration Medical Center (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Neeraj Kumar (Cleveland Heights, Ohio);  Joseph E. Willis (Shaker Heights, Ohio)
ABSTRACT Embodiments discussed herein facilitate determination of cancer stages based at least in part on shape, size, and/or texture features of cancer nuclei. One example embodiment is a method, comprising: accessing at least a portion of a digital whole slide image (WSI) comprising a tumor; segmenting (e.g., via a first deep learning model) the tumor on the at least the portion of the digital WSI; segmenting (e.g., via a second deep learning model) cancer nuclei in the segmented tumor; extracting one or more features from the segmented cancer nuclei; providing the one or more features extracted from the segmented cancer nuclei to a trained machine learning model; and receiving, from the machine learning model, an indication of a cancer stage of the tumor.
FILED Monday, January 04, 2021
APPL NO 17/140586
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 7/0012 (20130101) Original (OR) Class
G06T 7/41 (20170101)
G06T 7/62 (20170101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30024 (20130101)
G06T 2207/30028 (20130101)
G06T 2207/30081 (20130101)
G06T 2207/30096 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/40 (20180101)
G16H 30/40 (20180101)
G16H 50/20 (20180101)
G16H 70/60 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279868 Ma et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Jingchen Ma (New Haven, Connecticut);  Laurent Dercle (New York, New York);  Binsheng Zhao (Forest Hills, New York);  Lin Lu (New York, New York);  Lawrence H. Schwartz (New York, New York)
ABSTRACT Techniques measuring post contrast phase include collecting 3D medical imagery of a subject after injection with a contrast agent. A first set of slices is obtained in which each includes a first anatomical feature selected from a portal vein, aorta, inferior vena cava, liver, spleen or renal cortex. A second set of slices is obtained in which each includes a different second anatomical feature. A first image region is obtained from the first set and a different second image region from the second set. A trained convolutional neural network is configured to input the first image region to a first plurality of convolutional hidden layers and the second image region to a second plurality of convolutional hidden layers and output from both to a fully connected hidden layer that outputs a post contrast phase. Output data is presented based on the post contrast phase.
FILED Friday, May 21, 2021
APPL NO 17/303145
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/3233 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101) Original (OR) Class
G06T 2207/10081 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30056 (20130101)
G06T 2207/30096 (20130101)
G06T 2207/30101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280275 AKERMAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Envisagenics, Inc. (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Martin AKERMAN (New York, New York);  Maria Luisa PINEDA (New York, New York)
ABSTRACT Disclosed herein are systems and methods for quantification and analysis of alternative splicing events, and prediction of biological relevance of alternative splicing events comprising a software module: quantifying alternative splicing events using biological data related to a genome, a transcriptome, or both provided by a user; processing the quantified alternative splicing events with information stored in a database; identifying statistically significant alternative splicing events, predicting functional impact of alternative splicing events on protein structures, protein functions, RNA stability, RNA integrity, or biological pathways, predicting druggability and reversibility of aberrant splicing events as well as controllability of splicing in general using statistical modeling and machine learning algorithms
FILED Thursday, November 19, 2020
APPL NO 16/952231
CURRENT CPC
Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 5/20 (20190201)
G16B 25/10 (20190201)
G16B 40/30 (20190201)
G16B 50/30 (20190201) Original (OR) Class

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/10 (20180101)
G16H 20/30 (20180101)
G16H 50/20 (20180101)
G16H 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 20210275046 Liu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Secretary of the Army (SECARMY)
U.S. Army Institute of Surgical Research (USAISR)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) The Government of the United States as represented by the Secretary of the Army (Ft. Detrick, Maryland)
ASSIGNEE(S) The Government of the United States as represented by the Secretary of the Army (Ft. Detrick, Maryland)
INVENTOR(S) Nehemiah T. Liu (San Antonio, Texas);  Jose Salinas (San Antonio, Texas)
ABSTRACT The invention in at least one embodiment includes a method for providing a beat determination based on signals from a plurality of medical sensors in substantially real time, said method including: receiving in at least two analysis modules at least one signal (including an ECG signal and/or a pulse signal) from at least one medical sensor such that at least one analysis module receives one ECG signal and at least one analysis module receives one pulse signal; in each analysis module processing one signal through a plurality of detection algorithm modules to produce at least one quantitative decision, fusing the quantitative decisions together with a fusion module, and outputting at least one detected peak from the fusion module to an aggregation module; and producing from the aggregation module a series of detected peaks based on detected peaks received from the analysis modules. In a further embodiment, the detected peaks produced by the aggregation module are used to determine heart rate variability/complexity. At least one embodiment includes a system for performing any of the above methods.
FILED Thursday, May 13, 2021
APPL NO 17/319915
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/021 (20130101)
A61B 5/0245 (20130101)
A61B 5/352 (20210101)
A61B 5/02405 (20130101) Original (OR) Class
A61B 5/7203 (20130101)
A61B 5/7221 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275050 Ren et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
U.S. Army Medical Research and Development Command (USAMRDC)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) LR Technologies, Inc. (Rockville, Maryland)
ASSIGNEE(S)
INVENTOR(S) Eugene Yu-Jiun Ren (San Marcos, California);  Yexian Qin (Tuscon, Arizona);  Chiehping Lai (Rockville, Maryland)
ABSTRACT The present disclosure includes an electromagnetic field detection and monitoring system. The system includes a single-ended amplifier and an impedance matching circuit which matches the impedance caused by an air gap between tissue and an electrode. The system includes passive detection, active detection, and signal processing capabilities. At least one embodiment includes a body worn system with sensing, processing, communications, and data storage capabilities. The system provides wearable antennas to transfer the EMF energy in its electrical or magnetic forms into the sensor efficiently. A specially designed processing algorithm can process the collected data and generated the results for medical professionals to read and make decisions. The processing can include machine learning technique which decompose an EMF signal into EEG bands to perform feature extraction. The features can then be used to train a machine learning model to classify other EMF signals.
FILED Thursday, November 05, 2020
APPL NO 17/090259
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/05 (20130101) Original (OR) Class
A61B 5/25 (20210101)
A61B 5/363 (20210101)
A61B 5/369 (20210101)
A61B 5/721 (20130101)
A61B 5/6804 (20130101)
A61B 5/7264 (20130101)

Antennas, i.e Radio Aerials
H01Q 1/48 (20130101)
H01Q 1/273 (20130101)
H01Q 1/2291 (20130101)
H01Q 5/335 (20150115)
H01Q 21/28 (20130101)

Selecting
H04Q 9/00 (20130101)
H04Q 9/02 (20130101)
H04Q 2209/40 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275721 Francis et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Embody, Inc. (Norfolk, Virginia)
ASSIGNEE(S) Embody, Inc. (, None)
INVENTOR(S) Michael P. Francis (Norfolk, Virginia);  Stella Petrova (Blacksburg, Virginia);  Nicholas Thayer (Morrisville, North Carolina)
ABSTRACT A method for supporting repair of soft tissue with biopolymer fibers. Biopolymer is dissolved in acid in a closed container made of materials inert to the acid and to the collagen to form a biopolymer solution. The solution is stirred, then centrifuged to degas it. The degassed solution is put into syringes on a holder. The number of syringes equals the number of fibers in the bundle. The syringes are mounted in a rotatable holder. Essentially equal quantities of degassed solution are extruded from the syringes to produce fibers, which are gathered and fed into a formation buffer bath. The fibers are kept taught after extrusion and dehydrated in a dehydrating solution in a dehydrating bath. The fibers are wound a collector to collect the bundle. The fibers are used to support repair of soft tissue.
FILED Monday, May 24, 2021
APPL NO 17/328633
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 17/14 (20130101)
A61L 17/105 (20130101)
A61L 27/24 (20130101) Original (OR) Class
A61L 27/386 (20130101)
A61L 27/3804 (20130101)
A61L 2430/10 (20130101)

Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons
D01D 5/02 (20130101)
D01D 5/06 (20130101)
D01D 5/38 (20130101)
D01D 7/00 (20130101)

Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments
D01F 4/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275986 Cooks et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Army Research Office (ARO)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)
INVENTOR(S) Robert Graham Cooks (West Lafayette, Indiana);  Michael Stanley Wleklinski (Indianapolis, Indiana);  David Logsdon (West Lafayette, Indiana)
ABSTRACT The invention generally relates to systems and methods for increasing reaction yield. In certain embodiments, the invention provides systems for increasing a yield of a chemical reaction that include a pneumatic sprayer configured to generate a liquid spray discharge from a solvent. The solvent includes a plurality of molecules, a portion of which react with each other within the liquid spray discharge to form a reaction product. The system also includes a collector positioned to receive the liquid spray discharge including the unreacted molecules and the reaction product. The system also includes a recirculation loop connected from the collector to the pneumatic sprayer in order to allow the unreacted molecules and the reaction product to be recycled through the pneumatic sprayer, thereby allowing a plurality of the unreacted molecules to react with each other as the unreacted molecules cycle again through the system.
FILED Monday, May 17, 2021
APPL NO 17/322339
CURRENT CPC
Separation
B01D 5/0069 (20130101)
B01D 19/0031 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 4/002 (20130101)
B01J 14/00 (20130101)
B01J 19/26 (20130101)
B01J 19/087 (20130101)
B01J 19/2465 (20130101) Original (OR) Class
B01J 2219/0884 (20130101)

Spraying Apparatus; Atomising Apparatus; Nozzles
B05B 5/03 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 49/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276665 TAN et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Secretary of the Navy (SECNAV)
APPLICANT(S) BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan);  The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S) BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan);  The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S) Xaiobo TAN (Okemos, Michigan);  Thassyo DA SILVA PINTO (East Lansing, Michigan);  Demetris COLEMAN (East Lansing, Michigan);  Weilin HOU (Slidell, Louisiana);  Silvia MATT (Carriere, Mississippi);  Sergio RESTAINO (Alexandria, Virginia);  Freddie SANTIAGO (Fort Washington, Maryland);  Hongyang SHI (East Lansing, Michigan)
ABSTRACT An apparatus including a controllable fluid-contacting surface is provided. In another aspect, the present apparatus includes a flexible membrane and multiple actuators each having an output shaft or activation member coupled to a water-contacting membrane, with the shafts extending in a direction offset from the nominal outer surface of the membrane. A further aspect of the present apparatus includes an underwater vessel including a propulsion source, a flexible membrane having a water-contacting outer surface and an electronic controller including programmable software for actuating the actuators.
FILED Tuesday, October 29, 2019
APPL NO 16/667089
CURRENT CPC
Ships or Other Waterborne Vessels; Equipment for Shipping
B63B 1/32 (20130101) Original (OR) Class
B63B 79/15 (20200101)
B63B 79/40 (20200101)

Fluid Dynamics, i.e Methods or Means for Influencing the Flow of Gases or Liquids
F15D 1/007 (20130101)
F15D 1/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276690 Witt
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) LOCKHEED MARTIN CORPORATION (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S) Jonathan Witt (Fort Worth, Texas)
ABSTRACT According to an aspect, a pivoting sail fairing system includes a rotatable fairing, for rotation about a first axis of rotation of an aircraft, that includes a housing that defines a compartment arranged inward from the housing, the housing including a first orifice on a first surface and a second orifice on a second surface of the housing, and a first actuator mounted on a surface of the compartment inward from the housing
FILED Thursday, March 05, 2020
APPL NO 16/809936
CURRENT CPC
Aeroplanes; Helicopters
B64C 7/00 (20130101) Original (OR) Class
B64C 27/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276880 Zhang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)
INVENTOR(S) Xinghang Zhang (West Lafayette, Indiana);  Haiyan Wang (West Lafayette, Indiana);  Jin Li (West Lafayette, Indiana);  Jaehun Cho (West Lafayette, Indiana);  Xin Li Phuah (West Lafayette, Indiana);  Han Wang (Richland, Washington)
ABSTRACT Methods of increasing the deformability of ceramic materials, as a nonlimiting example, titanium dioxide, particularly through the introduction of defects, and to ceramic materials produced by such methods. Such a method increases the deformability of a ceramic material by introducing high-density pre-existing defects and oxygen vacancies in the ceramic material during a flash sintering process and then forming nano scale stacking faults and nanotwins in the ceramic material. Such a ceramic material contains high-density pre-existing defects and oxygen vacancies and nano scale stacking faults and nanotwins, and may exhibit deformability in a temperature range of room temperature to 600° C.
FILED Friday, March 06, 2020
APPL NO 16/811894
CURRENT CPC
Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 23/08 (20130101) Original (OR) Class

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/90 (20130101)
C01P 2004/03 (20130101)
C01P 2004/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276931 Reaves et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Air Systems Command (NAVAIR)
APPLICANT(S) Lynntech, Inc. (College Station, Texas)
ASSIGNEE(S)
INVENTOR(S) Kelley Reaves (College Station, Texas);  Jared Mike (College Station, Texas);  Richard Sanchez, JR. (Bryan, Texas);  Billy McCulloch (Bryan, Texas);  Anthony Giletto (College Station, Texas);  David M. Battaglia (College Station, Texas);  Kacey G. Ortiz (Auburn, Alabama)
ABSTRACT The present invention comprises formulations and method for additive manufacturing comprising: a pot-stable photo-curable polymer; one or more fillers; and one or more additives, wherein the formulation cures into a polymer in six hours or less upon exposure to light. In certain examples, the additive manufacturing is a moldless method of additive manufacturing by preparing a formulation comprising: a pot-stable photo-curable polymer, one or more fillers, and one or more additives, and exposing the formulation to light in an amount that substantially cures the polymer in 6 hours or less.
FILED Wednesday, November 27, 2019
APPL NO 16/698562
CURRENT CPC
Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives
C06B 21/0033 (20130101)
C06B 25/00 (20130101)
C06B 25/10 (20130101)
C06B 25/34 (20130101)
C06B 29/22 (20130101)
C06B 31/28 (20130101)
C06B 45/10 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277079 WATTERS et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
APPLICANT(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S) Alexander L. WATTERS (North Andover, Massachusetts);  Donald E. INGBER (Boston, Massachusetts);  Mark J. CARTWRIGHT (West Newton, Massachusetts);  Michael SUPER (Lexington, Massachusetts);  Martin ROTTMAN (St. Cloud, France);  Evangelia MURRAY (Worcester, Massachusetts);  Brendon DUSEL (West Roxbury, Massachusetts)
ABSTRACT Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.
FILED Wednesday, May 12, 2021
APPL NO 17/318343
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 47/42 (20130101)

Peptides
C07K 14/4726 (20130101)
C07K 14/4737 (20130101) Original (OR) Class
C07K 2319/30 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/569 (20130101)
G01N 33/6854 (20130101)
G01N 33/56911 (20130101)
G01N 33/56916 (20130101)
G01N 33/56938 (20130101)
G01N 33/56944 (20130101)
G01N 2333/4737 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277092 Crowe, JR. et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S) Vanderbilt University (Nashville, Tennessee)
INVENTOR(S) James E. Crowe, JR. (Nashville, Tennessee);  Seth Zost (Nashville, Tennessee);  Robert Carnahan (Nashville, Tennessee);  Pavlo Gilchuk (Nashville, Tennessee)
ABSTRACT The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
FILED Thursday, February 11, 2021
APPL NO 17/173417
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 2039/545 (20130101)

Peptides
C07K 16/10 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/31 (20130101)
C07K 2317/565 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/563 (20130101)
G01N 33/56983 (20130101)
G01N 2333/165 (20130101)
G01N 2800/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277108 SHUSTA et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Eric V. SHUSTA (Madison, Wisconsin);  Charles C. STUTZ (Waltham, Massachusetts)
ABSTRACT The present invention provides antibodies or antigen binding fragments thereof including single chain variable fragment (scFv) antibodies that specifically bind to the blood brain barrier in vivo and methods of use.
FILED Wednesday, July 24, 2019
APPL NO 17/260697
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6803 (20170801)

Peptides
C07K 16/28 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/565 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277172 DAI et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
APPLICANT(S) Lenore DAI (Phoenix, Arizona);  Aditi CHATTOPADHYAY (Chandler, Arizona);  Elizabeth NOFEN (Phoenix, Arizona);  Jin ZOU (San Diego, California);  Bonsung KOO (Tempe, Arizona)
ASSIGNEE(S)
INVENTOR(S) Lenore DAI (Phoenix, Arizona);  Aditi CHATTOPADHYAY (Chandler, Arizona);  Elizabeth NOFEN (Phoenix, Arizona);  Jin ZOU (San Diego, California);  Bonsung KOO (Tempe, Arizona)
ABSTRACT Compositions including a thermosetting polymer network and a mechanophore covalently bonded to the thermosetting polymer network are provided. Substrates including the compositions are provided. In addition, methods of making the compositions and methods of monitoring stress on a substrate comprising the compositions are provided.
FILED Monday, May 24, 2021
APPL NO 17/328490
CURRENT CPC
Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 59/1477 (20130101) Original (OR) Class
C08G 59/5006 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 5/20 (20130101)

Compositions of Macromolecular Compounds
C08L 63/00 (20130101)

Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure
G01L 1/241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277278 Benkoski et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Jason J. Benkoski (Catonsville, Maryland);  Rengaswamy Srinivasan (Ellicott City, Maryland);  Christopher M. Hoffman, Jr. (Odenton, Maryland);  Keith S. Caruso (Catonsville, Maryland)
ABSTRACT Coating compositions include a binder that has a first polymeric material that does not undergo ultraviolet (UV) degradation and/or does not absorb UV radiation/light. The coating compositions may further include at least a first UV-reflective pigment dispersed throughout the binder. The coating compositions may be provided in a cured form as a solid coating layer that may overly at least a portion of a substrate.
FILED Tuesday, March 03, 2020
APPL NO 16/807227
CURRENT CPC
Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 2003/265 (20130101)
C08K 2201/003 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 183/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277306 Cook et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Secretary of the Air Force (SECAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S) Gary Cook (Beavercreek, Ohio);  Ronald W. Stites (Beavercreek, Ohio)
ABSTRACT A method of treating a substrate comprises applying an electric field to a substrate comprising a layer of a dopant on at least one surface; applying a predetermined temperature to the substrate in the electric field; applying the electric field and the predetermined temperature for a time sufficient to induce migration of the dopant into the substrate to provide a doped substrate; and removing the electric field and returning the doped substrate to about room temperature, wherein the doped substrate is characterized in that a spectral laser output of the doped substrate exhibits a nominally single frequency having a linewidth less than about 5 nm. The substrate may be a glass material, a single crystal material, a poly-crystalline material, a ceramic material, or a semiconductor material, which may be optically transparent. Before treatment, the substrate may be an undoped substrate or a doped substrate.
FILED Tuesday, March 02, 2021
APPL NO 17/189377
CURRENT CPC
Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/883 (20130101) Original (OR) Class

Measurement of Nuclear or X-radiation
G01T 1/20 (20130101)

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277445 Eberhart et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) Integenx Inc. (Pleasanton, California)
ASSIGNEE(S)
INVENTOR(S) David Eberhart (Santa Clara, California);  Yuan Li (Dublin, California);  James Ogg (Sunnyvale, California);  Ezra Van Gelder (Palo Alto, California);  Stephen J. Williams (San Carlos, California);  Timothy Woudenberg (San Francisco, California);  Dean S. Burgi (Sunnyvale, California);  William D. Nielsen (San Jose, California)
ABSTRACT This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
FILED Friday, December 11, 2020
APPL NO 17/119874
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/527 (20130101)
B01L 3/502715 (20130101)
B01L 7/52 (20130101)
B01L 2200/028 (20130101)
B01L 2200/0647 (20130101)
B01L 2300/023 (20130101)
B01L 2300/0672 (20130101)
B01L 2400/0421 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/44704 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277452 Kim et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Jongmin Kim (Cambridge, Massachusetts);  Jocelyn Yoshiko Kishi (Boston, Massachusetts);  Peng YIN (Brookline, Massachusetts);  Steven Henry STRASSMANN (Brookline, Massachusetts);  Thomas Schaus (Arlington, Massachusetts)
ABSTRACT Provided herein are molecular verification (authentication) systems, methods and compositions that use molecular (DNA/RNA) circuitry to enable specific molecularly encrypted solutions.
FILED Tuesday, September 19, 2017
APPL NO 16/334643
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6818 (20130101) Original (OR) Class

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 30/018 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277453 SHAPIRO et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Interior (DOI)
APPLICANT(S) CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Mikhail G. SHAPIRO (Los Angeles, California);  Dan I. PIRANER (Pasadena, California);  Mohamad H. ABEDI (Azusa, California);  Brittany MOSER (Irvine, California);  Audrey LEE-GOSSELIN (Pasadena, California)
ABSTRACT Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.
FILED Wednesday, March 17, 2021
APPL NO 17/204782
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 7/52 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/00 (20130101)
C12N 15/63 (20130101)
C12N 15/1055 (20130101)
C12N 15/8217 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6825 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/53 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277475 MAHESHWARI et al.
FUNDED BY
Department of Defense (DOD)
Uniformed Services University of the Health Sciences (USU)
Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
APPLICANT(S) The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland);  University of Florida Research Foundation, Inc. (Gainesville, Florida);  Orlando Health, Inc., d/b/a Orlando Regional Medical Center (Orlando, Florida)
ASSIGNEE(S) The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland);  University of Florida Research Foundation, Inc. (Gainesville, Florida);  Orlando Health, Inc., d/b/a Orlando Regional Medical Center (Orlando, Florida)
INVENTOR(S) Radha K. MAHESHWARI (Rockville, Maryland);  Nagaraja S. BALAKATHIRESAN (Clarksburg, Maryland);  Manish BHOMIA (Rockville, Maryland);  Kevin K. WANG (Gainesville, Florida);  Linda PAPA (Windermere, Florida)
ABSTRACT The present invention relates to methods of diagnosing traumatic brain injury (TBI) in a subject. The present invention also relates to methods of monitoring the progression of the TBI in a subject.
FILED Thursday, April 08, 2021
APPL NO 17/225653
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 2600/118 (20130101)
C12Q 2600/178 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277544 King et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
U.S. Navy
APPLICANT(S) Propel, LLC (Pawtucket, Rhode Island)
ASSIGNEE(S)
INVENTOR(S) Clare King (Providence, Rhode Island);  Anjali Khemani (Providence, Rhode Island);  Birgit Leitner (Providence, Rhode Island)
ABSTRACT A machine knittable hybrid yarn for providing conductive traces through a textile is disclosed. The hybrid yarn includes conductive wires coated with an insulating material and twisted together with a nonconductive yarn. The nonconductive yarn is from a strong, inelastic, and nonconductive fiber, such as a meta-aramid or para-aramid that protects the integrity of the conductive wire during knitting. The conductive wire can be copper-clad stainless steel or copper wire is coated with polyurethane, and the nonconductive yarn can have no-drip and no-drip properties to allow ablation of the hybrid yarn to remove the conductive yarn and insulating coating on the wire such that the ablated region becomes externally conductive and suitable for making an electrical contact. The hybrid yarn can be bonded with nylon or similar polymer after twisting.
FILED Friday, April 10, 2020
APPL NO 16/845796
CURRENT CPC
Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads
D02G 3/12 (20130101)
D02G 3/36 (20130101)
D02G 3/045 (20130101)
D02G 3/047 (20130101)
D02G 3/441 (20130101) Original (OR) Class
D02G 3/443 (20130101)

Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles
D10B 2401/16 (20130101)
D10B 2501/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277827 Dierksmeier et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana)
ASSIGNEE(S) Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana)
INVENTOR(S) Douglas David Dierksmeier (Franklin, Indiana);  Douglas Boyd (Indianapolis, Indiana);  Douglas J. Snyder (Carmel, Indiana);  Graham Burkholder (Avon, Indiana);  William Barry Bryan (Indianapolis, Indiana)
ABSTRACT A system includes a housing for a gas turbine engine, and a fan disposed in the housing to rotate coaxially with a gas turbine included in the housing. The system also includes an inlet guide vane disposed in the housing in axial alignment with the fan and configured to have an open position where a first flow of air is received by the fan through the inlet guide vane, and a closed position where airflow through the inlet guide vane is obstructed. The system further includes a heat exchanger disposed in a supply passage in fluid communication with a second flow of air received by the fan. The second flow of air is received by the fan via the supply passage with the inlet guide vane in the open position or in the closed position.
FILED Monday, March 09, 2020
APPL NO 16/813491
CURRENT CPC
Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants
F02C 7/10 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2260/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278215 Vahala et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Space and Naval Warfare Systems (SPAWAR)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Kerry Vahala (Pasadena, California);  Jiang Li (Pasadena, California);  Yu-Hung Lai (Pasadena, California);  Myoung-Gyun Suh (Pasadena, California);  Seung Hoon Lee (Pasadena, California)
ABSTRACT A disk resonator is pumped by counterpropagating pump signals to produce corresponding counterpropagating Brillouin laser signals. The pump laser optical frequencies are separated by a frequency offset ΔνP but excite the same nominal resonator optical mode; the Brillouin laser optical frequencies are separated by a beat frequency ΔνL with 0<ΔνL<ΔνP. A photodetector receives the Brillouin laser signals and produces an electrical signal at the beat frequency ΔνL. The frequency offset ΔνP can be large so enough to prevent locking of the Brillouin laser signals onto a common Brillouin laser frequency. A signal processing system derives from the beat frequency ΔνL an estimated angular velocity component of the disk optical resonator about an axis substantially perpendicular to the disk optical resonator.
FILED Wednesday, February 12, 2020
APPL NO 16/789404
CURRENT CPC
Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry
G01C 19/661 (20130101)
G01C 19/727 (20130101) Original (OR) Class

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/30 (20130101)
H01S 3/0085 (20130101)
H01S 3/094096 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278549 Kassas et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Zak M. Kassas (Irvine, California);  Mahdi Maaref (Irvine, California);  Joe Khalife (Cossta Mesa, California)
ABSTRACT A vehicular simultaneous localization and mapping may fuse lidar data and pseudoranges extracted from ambient cellular LTE towers. An ICP algorithm may be used to extract odometry measurements from successive lidar scans. A robust and computationally efficient feature extraction method may be used to detect edge lines and feature points from the lidars point cloud. Then, a point registration technique using a maximum likelihood approach allows the estimation of the covariance of the odometry error, which is used in EKF propagation. The proposed approach consists of a mapping mode when GNSS signals are available and subsequently a SLAM mode when GNSS signals become unavailable. The cellular transmitters states, namely position and clock bias and clock drift, are continuously estimated in both modes. Simulation and experimental results validate the accuracy of these systems and methods, and provides lane-level localization without GNSS signals.
FILED Friday, August 23, 2019
APPL NO 17/270763
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 17/89 (20130101)
G01S 19/485 (20200501) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278566 Guo et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
United States Air Force (USAF)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Cheng Guo (Stanford, California);  Meng Xiao (Wuhan, China PRC);  Momchil Minkov (San Mateo, California);  Yu Shi (Redmond, Washington);  Shanhui Fan (Stanford, California)
ABSTRACT An isotropic imaging filter is provided that includes a photonic crystal slab, where the photonic crystal slab includes a square lattice of air through holes, a dielectric constant, a thickness (d), a through hole radius (r), and a lattice constant (a), where the square lattice of air holes are separated according to a value of the lattice constant, where the thickness is configured according to d=M(a), where the through hole radii is configured according to r=N(a), where the thickness and the hole radii are configured to generate isotropic bands of guided resonances of an incident image.
FILED Monday, February 22, 2021
APPL NO 17/181318
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 1/005 (20130101) Original (OR) Class
G02B 5/20 (20130101)
G02B 5/28 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278572 Shvets et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) IP Equity Management, LLC (Nashville, Tennessee)
ASSIGNEE(S) IP Equity Management, LLC (Nashville, Tennessee)
INVENTOR(S) Gennady Shvets (Austin, Texas);  Chih-Hui Wu (Austin, Texas)
ABSTRACT A solar thermophotovoltaic system has a heat exchanger containing a heat exchange fluid, and a thin-film integrated spectrally-selective plasmonic absorber emitter (ISSAE) in direct contact with an outer surface of the heat exchanger, the ISSAE including an ultra-thin non-shiny metal layer that is strongly absorbing in a solar spectral range and strongly reflective in an infrared spectral range. The metal layer has an inner surface in direct contact with an outer surface of the heat exchanger. A photovoltaic cell support structure with an inner surface in a concentric configuration partially surrounds the ISSAE; and an airgap separates the support structure and the outer surface of the metal layer. Photovoltaic cells are arranged on a portion of the inner surface of the support structure to receive emissions from the ISSAE, and a solar energy collector/concentrator allows solar radiation to impinge a portion of the metal layer.
FILED Friday, March 19, 2021
APPL NO 17/206213
CURRENT CPC
Solar Heat Collectors; Solar Heat Systems
F24S 60/30 (20180501)
F24S 70/225 (20180501)

Optical Elements, Systems, or Apparatus
G02B 5/008 (20130101) Original (OR) Class

Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules
H02S 10/30 (20141201)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 10/40 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278579 Garan
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
U.S. Navy
Office of Naval Research (ONR)
United States Navy (USN)
APPLICANT(S) BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S) BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S) Jacob D. Garan (Honolulu, Hawaii)
ABSTRACT The present disclosure relates generally to a method of use for a field flattening interference filter. More particularly, the present disclosure relates a field flattening bandpass interference filter with the cut-on edge of the pass band at the system wavelength at a normal angle of incidence. Further discussed is a method to extend the field flattening design to work at multiple system wavelengths through the optimized design of a multi-band interference filter.
FILED Tuesday, December 17, 2019
APPL NO 16/716921
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 5/208 (20130101)
G02B 5/288 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278684 Garan
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
United States Navy (USN)
APPLICANT(S) BAE SYSTEMS INFORMATION AND ELECTRONICS INTEGRATION INC. (Nashua, New Hampshire)
ASSIGNEE(S) BAE SYSTEMS INFORMATION AND ELECTRONICS INTEGRATION INC. (Nashua, New Hampshire)
INVENTOR(S) Jacob D. Garan (Honoulu, Hawaii)
ABSTRACT An optical assembly includes a plurality of polarizing beamsplitters (PBS) including a first PBS and a second PBS. Each PBS includes a similar splitting optical coating. The splitting optical coating on the second PBS is oriented as rotated 90° relative to the splitting optical coating on the first PBS. There may be a third PBS offset to another side of the first PBS. The splitting optical coating on the third PBS, which is similar to the splitting optical coating on the first PBS and the second PBS, is oriented as rotated 90° relative to the splitting optical coating on the first PBS. The splitting optical coatings on the second PBS and the third PBS may be oriented in the same direction. A beamsplitting assembly may be formed from the optical assembly by coupling image sensors to major surfaces of the second PBS and the third PBS.
FILED Wednesday, December 04, 2019
APPL NO 16/702706
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 27/123 (20130101)
G02B 27/283 (20130101) Original (OR) Class
G02B 27/1006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278706 Montoya et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Juan Montoya (Belmont, Massachusetts);  Daniel Ripin (Needham, Massachusetts);  Christopher Aleshire (Lexington, Massachusetts);  Dale Martz (Medford, Massachusetts);  Peter Colin Reeves-Hall (Northbridge, Massachusetts)
ABSTRACT An electro-optic beam controller, material processing apparatus, or optical amplifier, and corresponding methods, can include an actively controlled, waveguide-based, optical spatial mode conversion device. The conversion device can include a coupler, which can be a photonic lantern, configured to combine light beams into a common light beam; a sensor configured to measure at least one characteristic of the common light beam; and a controller configured to modulate optical parameters of the individual, respective light beams to set one or more spatial modes of the common light beam. Actively controlled and modulated devices can be used to maintain a stable, diffraction-limited beam for use in an amplification, communications, imaging, laser radar, switching, or laser material processing system. Embodiments can also be used to maintain a fundamental or other spatial mode in an optical fiber even while scaling to kilowatt power.
FILED Thursday, December 17, 2020
APPL NO 17/125919
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/2856 (20130101)

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/29 (20130101)
G02F 1/0115 (20130101) Original (OR) Class
G02F 1/0121 (20130101)

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278707 Moss et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Analog Photonics LLC (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Benjamin Roy Moss (Cambridge, Massachusetts);  Erman Timurdogan (Somerville, Massachusetts);  Christopher Vincent Poulton (Cambridge, Massachusetts);  Shahriar Shahramian (Warren, New Jersey)
ABSTRACT Controlling an optical phased array includes applying optical phase shifts by an array of phase shifter (PS) elements, each PS element applying an optical phase shift based on an input voltage signal applied across first and second terminals of the PS element, providing output voltage signals from an array of driver elements. During a charging time period, each driver element provides an output voltage signal to determine a corresponding input voltage signal applied across at least one of the PS elements; an array of switches control connectivity between the driver elements and respective PS elements; and all of the second terminals of all of the PS elements in the array of PS elements are maintained at a common voltage. The total number of switches in the array of switches is at least as large as the total number of PS elements in the array of PS elements.
FILED Thursday, March 04, 2021
APPL NO 17/192169
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/0121 (20130101) Original (OR) Class
G02F 2203/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278741 Ziemkiewicz et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Sea Systems Command (NAVSEA)
Naval Air Warfare Center (NAWC)
APPLICANT(S) Analog Devices, Inc. (Norwood, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Michael Ziemkiewicz (Lakewood, Colorado);  Scott Robert Davis (Denver, Colorado);  Michael Howard Anderson (Lyons, Colorado);  Bennett Sodergren (Golden, Colorado);  Radhika Marathe (Watertown, Massachusetts)
ABSTRACT An optical system for receiving light scanned from different light origination locations in space can include a Liquid Crystal (LC) waveguide (LCW), including first and second LCW light ports. A beamsteering LC electrode can be included in or coupled to the LCW and can be configured to vary a receiving direction of light received at the second LCW light port in response to a varying electrical input signal applied to the LC electrode to scan receiving of light at the second LCW light port from different light origination locations in space. A photodetector can be optically coupled to the first LCW light port, such as to detect waveguided light from different light origination locations in space received in response to the varying electrical input signal applied to the first LC electrode. Ranger, bright-spot locking, laser detection, direct detect and coherent lidar, wavelength detection, and other techniques and use cases are possible.
FILED Friday, August 16, 2019
APPL NO 16/543060
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 7/4817 (20130101)
G01S 17/08 (20130101)

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/313 (20130101) Original (OR) Class
G02F 2203/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278743 Huang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S) The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S) Chaoran Huang (Plainsboro, New Jersey);  Thomas Ferreira De Lima (Princeton, New Jersey);  Alexander Tait (Boulder, Colorado);  Siamak Abbaslou (Kendall Park, New Jersey);  Aashu Jha (Princeton, New Jersey);  Bhavin Shastri (Lawrenceville, New Jersey);  Paul R. Prucnal (Princeton, New Jersey);  Mitchell A. Nahmias (Princeton, New Jersey);  Hsuan-Tung Peng (Princeton, New Jersey)
ABSTRACT According to various embodiments, an all-optical thresholder device is disclosed. The all-optical thresholder device includes a Mach-Zehnder interferometer (MZI) coupled to a Mach-Zehnder coupler (MZC). The MZI includes at least one microring resonator (MRR) and a first tunable element, where the MRR further includes a second tunable element. The MZC includes a third tunable element. The first, second, and third tunable elements are configured to control biases of the all-optical thresholder device to achieve a desired power transfer function.
FILED Wednesday, January 29, 2020
APPL NO 16/775746
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/365 (20130101)
G02F 1/3517 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278854 Serrano et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)
INVENTOR(S) Christopher Serrano (Whittier, California);  Michael A. Warren (Northridge, California);  Aleksey Nogin (Fresno, California)
ABSTRACT Described is a system for training a neural network for estimating surface normals for use in operating an autonomous platform. The system uses a parallelizable k-nearest neighbor sorting algorithm to provide a patch of points, sampled from the point cloud data, as input to the neural network model. The points are transformed from Euclidean coordinates in a Euclidean space to spherical coordinates. A polar angle of a surface normal of the point cloud data is estimated in the spherical coordinates. The trained neural network model is utilized on the autonomous platform, and the estimate of the polar angle of the surface normal is used to guide operation of the autonomous platform within the environment.
FILED Tuesday, November 17, 2020
APPL NO 16/950803
CURRENT CPC
Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit
B60W 60/001 (20200201)

Systems for Controlling or Regulating Non-electric Variables
G05D 1/0221 (20130101) Original (OR) Class
G05D 1/0276 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278959 Keel et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Paul Erich Keel (, None)
ASSIGNEE(S)
INVENTOR(S) Paul Erich Keel (Cambridge, Massachusetts);  Jeffrey Huang (Lausanne, Switzerland)
ABSTRACT A computer-implemented method for interacting with at least one data item obtained from at least one source utilizes computer processes responsive to a user selection of the at least one data item and include causing configuring of each of the data items into a distinct information object by extracting, from each data item, extracted data including a picture, a heading, and a link to the data item, and causing storing of data corresponding to each of the information objects in a database system. The processes further include displaying a representation of each of at least two of the information objects in the database system, the representation being in a uniform format, wherein the format includes a card, and, within the card, in uniform locations thereof, the picture, the heading, a set of indicators, and a set of graphically accessible functions.
FILED Friday, May 07, 2021
APPL NO 17/314953
CURRENT CPC
Electric Digital Data Processing
G06F 3/0482 (20130101)
G06F 3/04817 (20130101)
G06F 3/04842 (20130101) Original (OR) Class
G06F 16/22 (20190101)
G06F 16/29 (20190101)
G06F 16/258 (20190101)
G06F 16/9535 (20190101)
G06F 16/9537 (20190101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/10 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 51/046 (20130101)
H04L 67/10 (20130101)

Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests
Y10S 707/99933 (20130101)
Y10S 707/99943 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279086 Walker et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Air Systems Command (NAVAIR)
APPLICANT(S) Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Brad A. Walker (Tucson, Arizona);  Richard D. Egbert (Sahuarita, Arizona);  Frederick K. Jones (Oro Valley, Arizona);  Jonathan Johansen (Oro Valley, Arizona)
ABSTRACT An apparatus includes at least one memory configured to store a virtualization associated with a programming and test platform and a munition. The virtualization includes a virtual machine containing first software or firmware instructions associated with the programming and test platform and second software or firmware instructions that control behavior of the programming and test platform relative to the munition. The virtualization also includes a virtual representation of the munition. The virtualization further includes one or more virtual communication channels configured to communicatively couple the virtual machine and the virtual representation of the munition. The apparatus also includes at least one processor configured to execute the virtualization and simulate the programming and test platform and the munition on the apparatus.
FILED Monday, February 17, 2020
APPL NO 16/792783
CURRENT CPC
Electric Digital Data Processing
G06F 9/44505 (20130101)
G06F 9/45558 (20130101) Original (OR) Class
G06F 11/1484 (20130101)
G06F 11/3672 (20130101)
G06F 2009/45579 (20130101)
G06F 2009/45595 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279338 Bowman et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
National Science Foundation (NSF)
APPLICANT(S) The George Washington University (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Benjamin Bowman (Kensington, Maryland);  H. Howie Huang (McLean, Virginia)
ABSTRACT The graph-based source code vulnerability detection system that uses a code-similarity style technique to identify highly modified vulnerable code clones while remaining generic to all vulnerability types. The system abstracts vulnerabilities in source code to the graph domain, allowing it to identify key relationships between textual elements that are not directly discernible from the text alone. Additionally, the system analyzes the patched code in addition to the vulnerable code to identify specific relationships in the graph that are tied directly to the vulnerable code segment, the patched code segment, and the contextual code of a particular vulnerability. By separating the vulnerability representation into these three components, a matching algorithm identifies vulnerable code clones while tolerating modifications at each level independently, providing more robust detection of modified vulnerable code clones.
FILED Thursday, March 04, 2021
APPL NO 17/192249
CURRENT CPC
Electric Digital Data Processing
G06F 8/71 (20130101)
G06F 8/75 (20130101)
G06F 16/9024 (20190101)
G06F 21/577 (20130101) Original (OR) Class
G06F 2221/033 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279369 Beigi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
APPLICANT(S) Ghazaleh Beigi (Tempe, Arizona);  Ruocheng Guo (Mianyang, China PRC);  Huan Liu (Tempe, Arizona);  Yanchao Zhang (Phoenix, Arizona);  Alexander Nou (Mesa, Arizona)
ASSIGNEE(S)
INVENTOR(S) Ghazaleh Beigi (Tempe, Arizona);  Ruocheng Guo (Mianyang, China PRC);  Huan Liu (Tempe, Arizona);  Yanchao Zhang (Phoenix, Arizona);  Alexander Nou (Mesa, Arizona)
ABSTRACT Systems and methods of privacy protection of a user may include compiling an actual number of links in a web history corresponding to each topic in a plurality of internet topics; compiling a topic probability distribution based on the web history; determining an additional number of links to be added to each topic in the plurality of internet topics; and modifying the topic probability distribution by selecting a set of links corresponding to the additional number of links for each topic in the plurality of internet topics.
FILED Wednesday, February 05, 2020
APPL NO 16/782349
CURRENT CPC
Electric Digital Data Processing
G06F 16/9536 (20190101)
G06F 16/9558 (20190101)
G06F 21/6263 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279492 Vemury et al.
FUNDED BY
Department of Homeland Security (DHS)
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S) Arun R. Vemury (North Bethesda, Maryland);  Yevgeniy B. Sirotin (Severna Park, Maryland);  Cynthia M. Cook (Pittsburg, Pennsylvania);  John J. Howard (Bethesda, Maryland);  Jerry L. Tipton (Severn, Maryland)
ABSTRACT In examples, a relative skin reflectance of a captured image of a subject is quantified. Based on the relative skin reflectance, the captured image is determined as suitable or not suitable for biometric identification. When the captured image is determined not suitable, a remedial capture setting is calculated and provided to an image capturing resource. Another captured image of the subject, captured under the remedial capture setting, is received from the image capturing resource. The relative skin reflectance of the another captured image is quantified and based thereon, there is a determining of whether the another captured image is suitable or is not suitable.
FILED Thursday, February 25, 2021
APPL NO 17/185588
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/036 (20130101) Original (OR) Class
G06K 9/00268 (20130101)
G06K 9/00288 (20130101)
G06K 9/2027 (20130101)
G06K 9/4661 (20130101)

Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere
G07C 9/00563 (20130101)

Pictorial Communication, e.g Television
H04N 5/243 (20130101)
H04N 5/2351 (20130101)
H04N 5/2354 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279519 Krim et al.
FUNDED BY
Department of Defense (DOD)
Missile Defense Agency (MDA)
APPLICANT(S) NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Hamid Krim (Raleigh, North Carolina);  Siddharth Roheda (Raleigh, North Carolina);  Sally Ghanem (Raleigh, North Carolina)
ABSTRACT An exemplified methods and systems provides a Volterra filter network architecture that employs a cascaded implementation and a plurality of kernels, a set of which is configured to execute an nth order filter, wherein the plurality of kernels of the nth order filters are repeatedly configured in a plurality of cascading layers of interconnected kernels to form a cascading hierarchical structure that approximates a high-order filter.
FILED Monday, March 01, 2021
APPL NO 17/188464
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00711 (20130101)
G06K 9/6257 (20130101) Original (OR) Class

Image Data Processing or Generation, in General
G06T 7/215 (20170101)
G06T 2207/10016 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279570 Warren et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) HRL Laboratories, LLC (Malibu, California)
ASSIGNEE(S)
INVENTOR(S) Michael A. Warren (Northridge, California);  Christopher Serrano (Whittier, California);  Aleksey Nogin (Fresno, California)
ABSTRACT Described is a system for proving correctness properties of a neural network for providing estimates for point cloud data. The system receives as input a description of a neural network for generating estimates from a set of point cloud data. The description of the neural network is parsed to obtain a symbolic representation. Based on a combination of the symbolic representation and a set of analysis parameters, the system generates an analysis output indicating whether the neural network satisfies a correctness property in generating the estimates from the set of point cloud data. The analysis output is a mathematical proof artifact proving that the set of analysis parameters is satisfied, a list of one or more point clouds for which the set of analysis parameters is violated, or a report that progress could not be made by the analysis.
FILED Thursday, October 22, 2020
APPL NO 17/078079
CURRENT CPC
Electric Digital Data Processing
G06F 7/544 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279620 Frank
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) BAE Systems Information And Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S) BAE Systems Information And Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S) Ronald James Frank (San Dimas, California)
ABSTRACT A method and system is disclosed for determining a probability that an encountered platform was of a specific type given that a plurality of emitters exist on the platform and each emitter has a computed probability that it is of each of a set of types. A preprocessing stage operates on a description of the environment and determines the probability of a set of events that are independent of any observation. A runtime processing stage uses the terms computed in the preprocessing stage along with data assembled from a set of observations to determine the conditional probability that a particular platform type was the type encountered.
FILED Tuesday, December 24, 2019
APPL NO 16/726532
CURRENT CPC
Electric Digital Data Processing
G06F 16/2272 (20190101)
G06F 17/16 (20130101)

Computer Systems Based on Specific Computational Models
G06N 7/005 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279624 Oliver et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) William D. Oliver (Arlington, Massachusetts);  Youngku Sung (Cambridge, Massachusetts);  Antti Pekka Vepsalainen (Malden, Massachusetts);  Jochen Braumueller (Somerville, Massachusetts);  Simon Gustavsson (Cambridge, Massachusetts)
ABSTRACT According to some embodiments, a method can identify and discriminate contributions from one or more noise sources using the multi-level structure of a quantum system with three or more levels. The method can include: preparing the quantum system in a predetermined state; applying one or more control signals to the quantum system; measuring values of one or more observables of the quantum system that quantify the quantum system's response to the noise sources and the one or more applied control signals; extracting noise spectra information associated with the noise sources from the measured values; and identifying contributions from the one or more noise sources based on the noise spectra information.
FILED Thursday, March 05, 2020
APPL NO 16/809659
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279631 Pichler et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Physics (PHY)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Hannes Pichler (Cambridge, Massachusetts);  Shengtao Wang (Somerville, Massachusetts);  Leo Xiangyu Zhou (Somerville, Massachusetts);  Soonwon Choi (El Cerrito, California);  Mikhail D. Lukin (Cambridge, Massachusetts)
ABSTRACT Systems and methods relate to selectively arranging a plurality of qubits into a spatial structure to encode a quantum computing problem. Exemplary arrangement techniques can be applied to encode various quantum computing problems. The plurality of qubits can be driven according to various driving techniques into a final state. The final state can be measured to identify an exact or approximate solution to the quantum computing problem.
FILED Friday, August 30, 2019
APPL NO 17/270741
CURRENT CPC
Optical Computing Devices;
G06E 1/00 (20130101)

Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279864 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio);  Louis Stokes Cleveland Veterans Administration Medical Center (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Neeraj Kumar (Cleveland Heights, Ohio);  Joseph E. Willis (Shaker Heights, Ohio)
ABSTRACT Embodiments discussed herein facilitate determination of cancer stages based at least in part on shape, size, and/or texture features of cancer nuclei. One example embodiment is a method, comprising: accessing at least a portion of a digital whole slide image (WSI) comprising a tumor; segmenting (e.g., via a first deep learning model) the tumor on the at least the portion of the digital WSI; segmenting (e.g., via a second deep learning model) cancer nuclei in the segmented tumor; extracting one or more features from the segmented cancer nuclei; providing the one or more features extracted from the segmented cancer nuclei to a trained machine learning model; and receiving, from the machine learning model, an indication of a cancer stage of the tumor.
FILED Monday, January 04, 2021
APPL NO 17/140586
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 7/0012 (20130101) Original (OR) Class
G06T 7/41 (20170101)
G06T 7/62 (20170101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30024 (20130101)
G06T 2207/30028 (20130101)
G06T 2207/30081 (20130101)
G06T 2207/30096 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/40 (20180101)
G16H 30/40 (20180101)
G16H 50/20 (20180101)
G16H 70/60 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279955 Michael et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Nathan Michael (Pittsburgh, Pennsylvania);  Shobhit Srivastava (San Diego, California)
ABSTRACT A system and method to generate perceptual models of the environment that optimally handle the variation in clutter and provide a multiresolution and multi-fidelity representation of the environment is described. The system and method is able to capture inherent structural dependencies, thereby allowing efficient and precise inferences to be drawn. The approach employs a hierarchy of Gaussian Mixtures to approximate the underlying spatial distribution.
FILED Thursday, August 31, 2017
APPL NO 16/330411
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6215 (20130101)
G06K 9/6288 (20130101)

Computer Systems Based on Specific Computational Models
G06N 7/005 (20130101)

Image Data Processing or Generation, in General
G06T 17/20 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280088 Sedberry et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
United States Marine Corps (USMC)
Joint Intermediate Force Capabilities Office (JIFCO)
Joint Non-Lethal Weapons Program (JNLWP)
Non-Lethal Weapons Directorate (JNLWD)
APPLICANT(S) CFD Research Corporation (Hunstville, Alabama)
ASSIGNEE(S)
INVENTOR(S) David Keith Sedberry (Huntsville, Alabama);  Vincent J. Harrand (Huntsville, Alabama);  Phillip E. Whitley (Huntsville, Alabama);  Andrzej Przekwas (Huntsville, Alabama)
ABSTRACT A modular surrogate can include: a body having an external body surface with an anatomical shape, wherein the body includes an internal chamber with at least one port formed in the body extending inwardly; at least one anatomical module having an external module portion and a module stem coupled thereto, the module stem being received into a corresponding module port of the at least one port, the external module portion having an external module surface with an anatomical shape, the external body surface matches with the external module surface to provide a continuous anatomical shape; at least one sensor located in the at least one anatomical module; and at least one controller, wherein when the at least one anatomical module is coupled with the body, the at least one sensor is capable of being operably coupled with the at least one controller.
FILED Tuesday, November 26, 2019
APPL NO 16/696997
CURRENT CPC
Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General
F41H 13/0056 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/00 (20130101)

Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams
G09B 23/34 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280310 Albert et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Secretary of the Air Force (SECAF)
APPLICANT(S) Government of the United States as represented by the Secretary of the Air force (Kirtland AFB, New Mexico)
ASSIGNEE(S) Government of the United States as represented by the Secretary of the Air force (Kirtland AFB, New Mexico)
INVENTOR(S) Michael D. Albert (Las Cruces, New Mexico);  David R. Desrochers (Fredericksburg, Virginia);  Christopher Valerino (Liverpool, New York)
ABSTRACT A system for detecting medical audio alarms. The system includes a detector and a server. The detector further comprises a microphone that is configured to receive a sound of the alarm; a microcontroller configured to determine an alarm pattern from the sound and to compare the determined alarm pattern to a plurality of patterns stored in a memory to identify a cause of the alarm; and a network interface configured to transmit the cause of the alarm. The server is configured receive the cause of the alarm and provide notification of the cause of the alarm.
FILED Wednesday, March 03, 2021
APPL NO 17/190970
CURRENT CPC
Signalling or Calling Systems; Order Telegraphs; Alarm Systems
G08B 21/18 (20130101)

Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding
G10L 25/51 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 40/67 (20180101) Original (OR) Class

Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems
H04R 1/08 (20130101)
H04R 1/406 (20130101)
H04R 3/005 (20130101)
H04R 2201/401 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280371 Wang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Qing Wang (Collegeville, Pennsylvania);  Qi Li (State College, Pennsylvania)
ABSTRACT The present document relates to multilayered dielectric composites for high-temperature applications and related methods.
FILED Tuesday, July 25, 2017
APPL NO 16/320919
CURRENT CPC
Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 4/14 (20130101) Original (OR) Class
H01G 4/1227 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280725 HAN et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Department of Energy (DOE)
APPLICANT(S) UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico);  AIR FORCE RESEARCH LAB (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Sang M. HAN (Albuquerque, New Mexico);  Omar Kamal ABUDAYYEH (Albuquerque, New Mexico);  Andre CHAVEZ (Albuquerque, New Mexico);  David M. WILT (Albuquerque, New Mexico)
ABSTRACT A metal matrix composite paste is provided for screen printing metal matrix composite contacts in a photovoltaic cell. The metal matrix composite paste includes a plurality of functionalized multi-walled carbon nanotubes in a metal paste. Because the metal matrix composite paste can have similar mechanical and chemical properties to a metal paste, it can be incorporated into standard metallization processes. The metal matrix composite contacts formed from the metal matrix composite paste can have increased ductility and self-healing capability to electrically bridge a gap caused by physical fracture of a busbar or gridline.
FILED Friday, June 28, 2019
APPL NO 17/257607
CURRENT CPC
Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties
H01B 1/04 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/18 (20130101)
H01L 31/02168 (20130101)
H01L 31/022425 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280732 Abouraddy et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida)
ASSIGNEE(S)
INVENTOR(S) Ayman F. Abouraddy (Orlando, Florida);  Massimo Maximilian L. Villinger (Orlando, Florida);  Abbas Shiri (Orlando, Florida);  Soroush Shabahang (Orlando, Florida);  Ali K. Jahromi (Orlando, Florida);  Chris H. Villinger (Orlando, Florida)
ABSTRACT A visibly transparent planar structure using a CPA scheme to boost the absorption of a multi-layer thin-film configuration, requiring no surface patterning, to overcome the intrinsic absorption limitation of the absorbing material. This is achieved in a multi-layer absorbing Fabry-Perot (FP) cavity, namely a thin-film amorphous silicon solar cell. Omni-resonance is achieved across a bandwidth of 80 nm in the near-infrared (NIR), thus increasing the effective absorption of the material, without modifying the material itself, enhancing it beyond its intrinsic absorption over a considerable spectral range. The apparatus achieved an increased external quantum efficiency (EQE) of 90% of the photocurrent generated in the 80 nm NIR region from 660 to 740 nm as compared to a bare solar cell. over the spectral range of interest.
FILED Monday, May 04, 2020
APPL NO 16/865486
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/075 (20130101) Original (OR) Class
H01L 31/202 (20130101)
H01L 31/0445 (20141201)
H01L 31/0547 (20141201)
H01L 31/1884 (20130101)
H01L 31/03762 (20130101)
H01L 31/022475 (20130101)
H01L 31/022483 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280772 EOM et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
National Science Foundation (NSF)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Chang-Beom EOM (Madison, Wisconsin);  Tianxiang NAN (Ithaca, New York);  Jonathon SCHAD (Madison, Wisconsin)
ABSTRACT Voltage-controlled spin field effect transistors (“spin transistors”) and methods for their use in switching applications are provided. In the spin transistors, spin current is transported from a spin injection contact to a spin detection contact through a multiferroic antiferromagnetic channel via magnon propagation. The spin current transport is modulated by the application of a gate voltage that increases the number of domain boundaries the multiferroic antiferromagnetic material.
FILED Thursday, March 05, 2020
APPL NO 16/809970
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/22 (20130101)
H01L 29/78 (20130101)
H01L 29/82 (20130101)
H01L 43/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280775 BUHRMAN et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
National Nanotechnology Coordinated Infrastructure (NNCI)
Office of the Director of National Intelligence (ODNI)
Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S) Cornell University (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Robert A. BUHRMAN (Ithaca, New York);  Lijun ZHU (Ithaca, New York)
ABSTRACT Methods, systems, and devices are disclosed for enhancement of spin-orbit torque. In one aspect, a magnetic device includes a magnetic tunneling junction (MTJ), including a free magnetic layer, a pinned magnetic layer and a non-magnetic junction layer between the free magnetic layer and the pinned magnetic layer, and a spin Hall effect metal layer that includes one or more insertion metal layers operable to introduce interfacial scattering of electrons flowing in the spin Hall metal layer to increase the spin current that interacts with and changes the magnetization of the free magnetic layer of the MTJ.
FILED Monday, March 16, 2020
APPL NO 16/820496
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 43/04 (20130101) Original (OR) Class
H01L 43/06 (20130101)
H01L 43/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280851 Freeman et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Sea Systems Command (NAVSEA)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Adam W. Freeman (Laurel, Maryland);  Konstantinos Gerasopoulos (Odenton, Maryland);  Spencer A. Langevin (Odenton, Maryland)
ABSTRACT Electrodes including a passivation layer formed prior to receiving an initial charge are provided. The electrodes comprise an electrode-composition including an active electrode species, in which the electrode-composition comprises a first surface. The electrodes also comprise a passivation layer positioned onto at least a portion of the first surface. The passivation layer comprises: (i) a matrix material comprising (a) a cured propoxylated polymer, (b) an uncured hydrophobic glycol ether, or a combination of (a) and (b); and (ii) at least a first electrolyte. The electrodes may be included into an electrochemical cell.
FILED Saturday, August 31, 2019
APPL NO 16/558044
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/366 (20130101) Original (OR) Class
H01M 4/0407 (20130101)
H01M 4/623 (20130101)
H01M 10/0525 (20130101)
H01M 10/0565 (20130101)
H01M 10/0568 (20130101)
H01M 10/0569 (20130101)
H01M 2004/021 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280955 Behdad et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Nader Behdad (Oregon, Wisconsin);  John H. Booske (McFarland, Wisconsin);  Hung Thanh Luyen (Madison, Wisconsin);  Zongtang Zhang (Madison, Wisconsin)
ABSTRACT A waveguide includes a first double-ridge waveguide, a second double-ridge waveguide, and a polarization rotator. The first double-ridge waveguide provides a phase of an input electrical field rotated 0° or 90°. The second double-ridge outputs an electric field with a polarization that is perpendicular to a first polarization of the input electrical field. The polarization rotator is mounted between the first double-ridge waveguide and the second double-ridge waveguide and includes a frame, a dielectric layer, a first conducting pattern layer forming a first conductor and a second conductor, a first switch connected between the first conductor and the second conductor, a second conducting pattern layer forming a third conductor and a fourth conductor, and a second switch connected between the third conductor and the fourth conductor. Wherein a phase rotation of 90° or −90° is provided by the polarization rotator based on a state of the first and second switch.
FILED Tuesday, January 07, 2020
APPL NO 16/735846
CURRENT CPC
Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type
H01P 1/165 (20130101)
H01P 3/123 (20130101) Original (OR) Class

Antennas, i.e Radio Aerials
H01Q 1/50 (20130101)
H01Q 21/0006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280972 Behdad et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Nader Behdad (Oregon, Wisconsin);  John H. Booske (McFarland, Wisconsin);  Hung Thanh Luyen (Madison, Wisconsin)
ABSTRACT A phase shift element includes a first dielectric layer, a conductive layer, a second dielectric layer, a conducting pattern layer, switches, and vertical interconnect accesses (vias). Each conductor of a plurality of conductors of the conducting pattern layer is orthogonal to two other conductors. Each switch is switchable between a conducting position and a non-conducting position. Each via is connected to a single conductor. The first conductive material reflects an electromagnetic wave incident on the conducting pattern layer and on the second dielectric layer. When a switch is in the conducting position, the switch electrically connects two conductors to each other through their respective vias. A plurality of different switch configurations of the switches provide a 2-bit phase quantization on the reflected electromagnetic wave relative to the electromagnetic wave incident on the conducting pattern layer when the electromagnetic wave is incident on the conducting pattern layer.
FILED Tuesday, October 08, 2019
APPL NO 16/595961
CURRENT CPC
Antennas, i.e Radio Aerials
H01Q 3/38 (20130101) Original (OR) Class
H01Q 3/247 (20130101)
H01Q 15/002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210281069 MacLaren et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
U.S. Air Force
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Brice MacLaren (Wellesley, Massachusetts);  James Macomber (North Grafton, Massachusetts);  Megan Richardson (Cohasset, Massachusetts)
ABSTRACT In one aspect, a method to determine a capacity of a microgrid includes applying a current test load to the microgrid and measuring a current through an energy storage device, the current indicating a charging status of the energy storage device based on a current load being applied to the microgrid through activated power outlets being served by the microgrid and the current test load, the energy storage device being integrated with the microgrid. The method also includes, responsive to a determination that the measured current based on the current load being applied to the microgrid and the current test load indicates that the energy storage device is discharging, determining the capacity of the microgrid, wherein the capacity is the current load being applied to the microgrid through activated power outlets and a test load applied to the microgrid immediately preceding the current test load.
FILED Thursday, February 25, 2021
APPL NO 17/185248
CURRENT CPC
Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 3/003 (20200101) Original (OR) Class
H02J 7/0031 (20130101)
H02J 2207/30 (20200101)
H02J 2300/24 (20200101)
H02J 2310/10 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210281150 Dawidowicz
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Secretary of the Army (SECARMY)
APPLICANT(S) The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Edward Dawidowicz (Jackson, New Jersey)
ABSTRACT Various embodiments associated with a segmented magnetic core are described. The segmented magnetic core can be made up of multiple singular structures so as to allow an individual singular structure to be removed with ease and without disturbing another magnetic core. This modular core design allows for a significant reduction in motor housing weight due to compatibility of the design with lightweight materials and the potential absence of extensive housing when so designed. This modular core design can be incorporated into a motor or a generator and this modular core design can be accomplished, in one example, by way of stacking and/or interlocking employing low cost assembly. In one example, a motor or a generator uses sensors to detect an operational failure in a magnetic core, notifying a user early of the failure.
FILED Monday, May 24, 2021
APPL NO 17/327809
CURRENT CPC
Dynamo-electric Machines
H02K 1/14 (20130101)
H02K 1/141 (20130101)
H02K 1/2706 (20130101)
H02K 15/0006 (20130101) Original (OR) Class
H02K 15/022 (20130101)
H02K 41/031 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210281241 Safavi-Naeini et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Amir H. Safavi-Naeini (Palo Alto, California);  Marek Pechal (Zurich, Switzerland);  Patricio Arrangoiz-Arriola (Menlo Park, California);  Edward Alexander Wollack (Clarksville, Maryland)
ABSTRACT A coupled storage qubit nanomechanical resonator in a processing qubit superconducting circuit is provided that includes a phononic crystal resonator (PCR) film disposed on a substrate, where the PCR film includes a defect mode in a bandgap of the PCR film where a storage qubit is encoded, a pair of electrodes generate voltages within the PCR film, where the defect is dimensioned to support a unique electrical potential generated by a local mechanical phonon mode of the PCR film, where a unique resonance frequency that is dependent on the defect dimensions is output from the PCR film, a coupling capacitor that is coupled to the PCR film, where the coupling capacitor is disposed to receive the output unique resonance frequency, and a processing qubit, where the processing qubit is capacitively coupled to the PCR film by the coupling capacitor, where the storage qubits are connected to the processing qubits.
FILED Monday, August 26, 2019
APPL NO 16/551004
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101)

Impedance Networks, e.g Resonant Circuits; Resonators
H03H 9/24 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210281302 Castañeda Fernandez et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Cornell University (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Oscar Fernando Castañeda Fernandez (New York, New York);  Christoph Emanuel Studer (New York, New York)
ABSTRACT Finite-alphabet beamforming for multi-antenna wideband systems is provided. The combination of massive multi-user multiple-input multiple-output (MU-MIMO) technology and millimeter-wave (mmWave) communication enables unprecedentedly high data rates for radio frequency (RF) communications. In such systems, beamforming must be performed at extremely high rates over hundreds of antennas. For example, spatial equalization applies beamforming in the uplink to mitigate interference among user equipment (UEs) at a base station (BS). Finite-alphabet equalization provides a new paradigm that restricts the entries of a spatial equalization matrix to low-resolution numbers, enabling high-throughput, low-power, and low-cost equalization hardware. Similarly, precoding applies beamforming in the downlink to maximize the reception of a signal transmitted from a BS to a target UE. Finite-alphabet precoding can be applied in the downlink to similarly improve power and cost in precoding hardware.
FILED Thursday, March 05, 2020
APPL NO 16/809813
CURRENT CPC
Transmission
H04B 7/0404 (20130101)
H04B 7/0452 (20130101)
H04B 7/0456 (20130101)
H04B 7/0617 (20130101) Original (OR) Class

Transmission of Digital Information, e.g Telegraphic Communication
H04L 25/0202 (20130101)
H04L 25/03936 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210281329 Sertel et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Kubilay Sertel (Columbus, Ohio);  Niru Nahar (Columbus, Ohio);  Syed An Nazmus Saqueb (Columbus, Ohio)
ABSTRACT Example systems and methods for antenna pattern characterization are described herein. The systems and methods are based on compressive sensing. An example method can include arranging a test antenna and a probe antenna in a spaced apart relationship; arranging a spatial light modulator within in a near field region of the test antenna; and projecting, using a light source, a plurality of light patterns onto the spatial light modulator. The method can also include transmitting, using the test antenna, a respective beam while each of the light patterns is projected onto the spatial light modulator; and receiving, using the probe antenna, a respective signal corresponding to each of the respective beams transmitted by the test antenna. The method can further include reconstructing the test antenna's near field using the respective signals received by the probe antenna. The test antenna's near field can be reconstructed using a compressive sensing algorithm.
FILED Thursday, August 01, 2019
APPL NO 16/529180
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 29/10 (20130101)

Transmission
H04B 17/12 (20150115)
H04B 17/16 (20150115)
H04B 17/0085 (20130101)
H04B 17/102 (20150115) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210281361 Hutchinson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Meredith N. Hutchinson (Washington, District of Columbia);  Jonathan M. Nichols (Crofton, Maryland);  Gustavo K. Rohde (Crozet, Virginia);  Nicole Menkart (Potomac, Maryland);  Geoffrey A. Cranch (Fairfax Station, Virginia)
ABSTRACT Methods, apparatuses, and systems for calculating time delays by a Wasserstein approach are provided. A plurality of signals are recorded by a plurality of sensors (three or more), respectively, and received at a controller. The plurality of signals recorded by the plurality of sensors are generated in response to a signal emitted by a source. The plurality of signals are converted into a plurality of probability density functions. A cumulative distribution transform for each of the plurality of probability density functions is calculated. A time delay for each unique pair of the plurality of sensors is calculated by minimizing a Wasserstein distance between two cumulative distribution transforms corresponding to the unique pair of the plurality of sensors
FILED Thursday, June 18, 2020
APPL NO 16/905842
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 1/0631 (20130101)
H04L 1/0681 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210281412 Khoury et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
APPLICANT(S) Raytheon BBN Technologies Corp. (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Joud Khoury (Boston, Massachusetts);  Michael Hassan Atighetchi (Framingham, Massachusetts);  Zachary Ratliff (Somerville, Massachusetts)
ABSTRACT Techniques for verifiable computation for cross-domain information sharing are disclosed. An untrusted node in a distributed cross-domain solution (CDS) system is configured to: receive a first data item and a first cryptographic proof associated with the first data item; perform a computation on the first data item including one or more of filtering, sanitizing, or validating the first data item, to obtain a second data item; generate, using a proof-carrying data (PCD) computation, a second cryptographic proof that indicates (a) validity of the first cryptographic proof and (b) integrity of the first computation on the first data item; and transmits the second data item and the second cryptographic proof to a recipient node in the distributed CDS system. Alternatively or additionally, the untrusted node may be configured to transmit a cryptographic proof to a trusted aggregator in the CDS system.
FILED Wednesday, February 10, 2021
APPL NO 17/172825
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/3218 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 20210275013 Alvarez et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) New Jersey Institute of Technology (Newark, New Jersey)
ASSIGNEE(S) New Jersey Institute of Technology (Newark, New Jersey)
INVENTOR(S) Tara Lynn Alvarez (Whippany, New Jersey);  Chang Yaramothu (Hackensack, New Jersey);  John Vito d'Antonio-Bertagnolli (Mount Laurel, New Jersey);  Mitchell Scheiman (Bala Cynwyd, Pennsylvania)
ABSTRACT Exemplary embodiments of the present disclosure relate to systems, methods, and apparatus to objectively assess binocular dysfunction for screening, diagnoses, and evaluation of vision/oculomotor function before, during, and after various forms of therapeutic interventions. Systems and methods of the present disclosure diagnose and assess binocular dysfunction objectively and automatically, can render a visual stimulus on one or more displays, and can control accommodative and proximal vergence stimulation of a user's eyes.
FILED Tuesday, June 18, 2019
APPL NO 17/253300
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 3/005 (20130101)
A61B 3/08 (20130101) Original (OR) Class
A61B 3/032 (20130101)
A61B 3/113 (20130101)
A61B 5/7267 (20130101)

Optical Elements, Systems, or Apparatus
G02B 30/36 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275091 Muthuswamy
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Jitendran Muthuswamy (Chandler, Arizona)
ASSIGNEE(S) Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S) Jitendran Muthuswamy (Chandler, Arizona)
ABSTRACT Rapid assessment of microcirculation in tissue to realize closed-loop systems is provided. Microcirculatory assessment systems according to embodiments described herein allow a user to assess changes in local blood flow in microvasculature in real-time using conventional electrical techniques. Some embodiments provide a closed-loop system that allows calibrated doses of electrical stimulation to be delivered in a deep brain stimulation (DBS) system depending on blood flow changes (in specific regions of the brain) being fed back to a controller. The approach described here is readily translatable with very minimal changes to existing hardware. Such closed-loop systems will improve the accuracy of electrode placement in DBS surgery and potentially reduce surgery time, optimize the delivery of electrical stimulation, increase battery life of implantable DBS systems, reduce post-surgical visits to medical practitioners and improve the quality of life of patients.
FILED Tuesday, March 09, 2021
APPL NO 17/196306
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0265 (20130101)
A61B 5/4836 (20130101) Original (OR) Class
A61B 5/4839 (20130101)
A61B 5/7257 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/0534 (20130101)
A61N 1/36135 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275464 Papoutsakis et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Eleftherios T. Papoutsakis (Newark, Delaware);  Emily Day (Landenburg, Pennsylvania);  Erica Winter (West Chester, Pennsylvania);  Jenna Harris (Cummington, Massachusetts);  Chen-Yuan Kao (Newark, Delaware);  Samik Das (Wilmington, Delaware)
ASSIGNEE(S) University of Delaware (Newark, Delaware)
INVENTOR(S) Eleftherios T. Papoutsakis (Newark, Delaware);  Emily Day (Landenburg, Pennsylvania);  Erica Winter (West Chester, Pennsylvania);  Jenna Harris (Cummington, Massachusetts);  Chen-Yuan Kao (Newark, Delaware);  Samik Das (Wilmington, Delaware)
ABSTRACT The present invention provides bio-nanoparticles (BioNPs) for delivering an active agent into hematopoietic stem & progenitor cells (HSPCs). Each BioNP comprises a core and a biological membrane covering the core, which comprises the active agent and a polymer. The biological membrane comprises a phospholipid bilayer and one or more surface proteins of a megakaryocyte (Mk). The active agent remains active after being delivered into the HSPC. Also provided are methods for preparing the BioNPs and uses of the BioNPs for targeted delivery of an active agent into HSPCs and/or treating or preventing a disease or condition in a subject in need thereof.
FILED Monday, May 24, 2021
APPL NO 17/327932
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5153 (20130101)
A61K 9/5184 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275651 Steinmetz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Nicole F. Steinmetz (San Diego, California);  Frank Alexander Veliz (Cleveland, Ohio);  Brylee David B. Tiu (Cleveland, Ohio)
ABSTRACT A nanoparticle construct includes a plurality of plant virus or virus-like particles electrostatically coupled to a plurality of nanoparticles having a different surface charge than the plant virus or virus-like particles. The nanoparticle construct upon delivery to a subject can provide a sustained release of the plant virus or virus-like particles and/or nanoparticles to a cell or tissue of the subject.
FILED Friday, July 21, 2017
APPL NO 16/319765
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/0011 (20130101) Original (OR) Class
A61K 39/39 (20130101)
A61K 39/385 (20130101)
A61K 47/6901 (20170801)
A61K 2039/585 (20130101)
A61K 2039/622 (20130101)
A61K 2039/645 (20130101)
A61K 2039/5258 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275679 DEANGELIS
FUNDED BY
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S) The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
ASSIGNEE(S)
INVENTOR(S) Paul L. DEANGELIS (Edmond, Oklahoma)
ABSTRACT Compositions, methods, and systems for the development and use of heparosan as a therapeutic modifying agent or vehicle which can modulate drug cargo pharmacokinetics and behavior within a mammalian patient.
FILED Thursday, March 11, 2021
APPL NO 17/199270
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/61 (20170801) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275725 Almarza et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania)
ASSIGNEE(S) UNIVERSITY OF PITTSBURGH-OF TH COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania)
INVENTOR(S) Alejandro Almarza (Pittsburgh, Pennsylvania);  Adam Chin (Pembroke Pines, Florida);  Juan Taboas (Pittsburgh, Pennsylvania);  Yadong Wang (Ithaca, New York)
ABSTRACT The invention relates to biodegradable, biocompatible materials to promote regeneration of articular surfaces in the temporomandibular joint and, more particularly, to biomaterials and methods for facilitating fibrochondrocyte and chondrocyte growth in in-vitro and in-vivo environments. The materials include magnesium in solid form and polymer. The materials are effective to grow and regenerate fibrochondrocyte and chondrocyte cells, and restore bone cells.
FILED Monday, September 11, 2017
APPL NO 16/330538
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/56 (20130101)
A61L 27/446 (20130101) Original (OR) Class
A61L 27/3817 (20130101)
A61L 2430/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276253 ERB et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Randall ERB (Newton, Massachusetts);  Robert ZANDO (Boston, Massachusetts);  Alain KARMA (Belmont, Massachusetts);  Ataollah MESGARNEJAD (Covington, Louisiana)
ABSTRACT A composite material of particles disposed in a matrix material is provided in which the particles have an asymmetric geometric shape with a longest dimension and a shortest dimension different from the longest dimension. Adjacent volume portions of the composite material are arranged in a mosaic pattern to abut along an interface or surface forming a common boundary between the adjacent volume portions. The particles within the adjacent volume portions are arranged with differing orientations with respect to the interface. The orientations of the particles in the adjacent volume portions are selected so that a crack propagating on a crack propagation path through one or the other of the adjacent volume portions stops at or deflects to propagate along the interface. Methods of making composite materials are also provided.
FILED Monday, March 08, 2021
APPL NO 17/194399
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/165 (20170801) Original (OR) Class
B29C 64/188 (20170801)
B29C 64/264 (20170801)
B29C 64/307 (20170801)
B29C 70/04 (20130101)

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2305/02 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 70/10 (20200101)
B33Y 80/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276891 Li et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S)
INVENTOR(S) Wenzhen Li (Ames, Iowa);  Hengzhou Liu (Ames, Iowa);  Yifu Chen (Ames, Iowa)
ABSTRACT The present application relates to a system for removal of nitrate from water. The system includes a first reactor comprising a porous oxide-derived silver electrode (OD-Ag) for electrocatalytic reduction of nitrate (NO3) to nitrite (NO2) and a second reactor comprising a Pd-based catalyst for catalytic reduction of nitrite (NO2). Also disclosed is a method of removing nitrate from water.
FILED Monday, March 08, 2021
APPL NO 17/195321
CURRENT CPC
Separation
B01D 53/18 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/4676 (20130101) Original (OR) Class
C02F 1/46109 (20130101)
C02F 2001/46133 (20130101)
C02F 2101/163 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 30/8624 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277410 DELLAPORTA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Research Resources (NCRR)
National Science Foundation (NSF)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut);  RHODE ISLAND COUNCIL ON POSTSECONDARY EDUCATION (Warwick, Rhode Island)
ASSIGNEE(S)
INVENTOR(S) Stephen L. DELLAPORTA (Branford, Connecticut);  Andrew HAYWARD (Madison, Connecticut);  Maria MORENO (Branford, Connecticut);  Albert KAUSCH (Stonington, Connecticut);  John MOTTINGER (North Kingstown, Rhode Island)
ABSTRACT The present invention pertains to genetically modified plants, particularly maize, sorghum and rice, with an all pistillate or all staminate phenotype and methods of the same. The survival of functional pistils in maize requires the action of the sk1 gene. SK1 encodes a glycosyltransferase (GT) that protects pistils from tasselseed-mediated cell death. sk1-dependent pistil protection at a developing floret gives rise to stamen arrest at the same floret, and so determines the pistillate floral fate. This is the first single gain-of-function gene known to control sexuality. The present invention further provides a direct strategy to extend hybrid technologies to related cereals such as sorghum and rice. Tasselseed and silkless genes represent major sex determination genes in maize, a pathway that permits the efficient production of hybrid seed and the associated benefits of heterosis-increased yield, resistance to pathogens, etc. Except for maize, current hybrid systems in cereals are fraught with genetic and environmental limitations. Genotype-independent hybrid cereal technology could potentially increase crop yields as much as 20-40% without placing additional land under agricultural production. This has profound implications for food security and the environmental impact of agriculture in some of the poorest regions of the world.
FILED Friday, August 11, 2017
APPL NO 16/326490
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/829 (20130101)
C12N 15/8212 (20130101)
C12N 15/8213 (20130101)
C12N 15/8216 (20130101) Original (OR) Class
C12N 15/8289 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277661 Liu et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Office of Emerging Frontiers in Research and Innovation (EFRI)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Cheng-Yun Karen Liu (Atlanta, Georgia);  Sehoon Ha (Atlanta, Georgia);  Yun Seong Song (Atlanta, Georgia);  Lena Ting (Atlanta, Georgia)
ABSTRACT In a method for recycling energy from stairs, a step platform is moveable between an upper and lower position. An energy storage device, coupled to the platform, stores energy when a downward force is applied thereto, causing the step platform to move to the lower position. The energy storage device (also releases stored energy as the step platform moves from to the upper position. A controllable locking mechanism (locks the step platform in the lower position when the downward force has caused the step platform to move into the lower position. A sensor determines when a downward force has been applied to the next higher step platform. A controller signals the controllable locking mechanism to unlock the step platform when the step platform is in the lower position, and when the downward force has been applied to the next higher step platform.
FILED Tuesday, April 13, 2021
APPL NO 17/228854
CURRENT CPC
Elevators; Escalators or Moving Walkways
B66B 9/0869 (20130101)

Finishing Work on Buildings, e.g Stairs, Floors
E04F 11/104 (20130101) Original (OR) Class
E04F 2011/1046 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278285 Chakrabartty et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S) Shantanu Chakrabartty (St. Louis, Missouri);  Liang Zhou (St. Louis, Missouri)
ABSTRACT A sensor system for detecting events includes an array of memory devices and a read-out interface. Each memory device includes a floating-gate with a sensing interface, the sensing interface having an energy barrier configured to leak electrons at a predetermined electron leakage rate through Fowler-Nordheim (F-N) tunneling. An input to the sensing interface is configured to alter a geometry of the energy barrier to change the electron leakage rate. The read-out interface is communicatively coupled to at least one memory device, and is configured to retrieve data stored on the at least one memory device for analysis.
FILED Thursday, May 20, 2021
APPL NO 17/325863
CURRENT CPC
Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves
G01H 11/06 (20130101)

Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for
G01K 3/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278367 Herr et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Child Health and Human Development (NICHD)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Amy E. Herr (Berkeley, California);  Lin He (Berkeley, California);  Andrew J. Modzelewski (Berkeley, California);  Elisabet Rosàs-Canyelles (Berkeley, California)
ABSTRACT Dual nucleic acid and protein isoform measurements are performed on low starting cell numbers (e.g. equivalent to the number of blastomeres composing early embryonic development stages (morula and blastocysts)), comprising integrating fractionation polyacrylamide gel electrophoresis (fPAGE) of 10-100 cells with off-chip analysis of nucleic acids in the nuclei.
FILED Monday, May 24, 2021
APPL NO 17/327806
CURRENT CPC
Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 9/40 (20130101)
C08J 2333/26 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 5/1545 (20130101)

Compositions of Macromolecular Compounds
C08L 33/26 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/44747 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278404 ERICKSON et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) David ERICKSON (Ithaca, New York);  Seoho LEE (Ithaca, New York);  Saurabh MEHTA (Ithaca, New York);  Sasank Sai VEMULAPATI (Ithaca, New York);  Elizabeth Grace REY (Ithaca, New York);  Dakota O'DELL (Ithaca, New York)
ABSTRACT A competitive diagnostic assay strip includes a first layer on a substrate for receiving, absorbing, and filtering a liquid sample. A second layer is on the substrate downstream of the first layer and includes a specific binding partner of a target molecule that will bind to the target molecule and produce a complex. A third layer is on the substrate downstream of the second layer and includes test and control regions. The test region has target molecules which will bind to and immobilize the complex in the test region. The control region has a moiety which will non-specifically bind to and immobilize the binding partner in the control region. In one embodiment, a spacer layer is on the substrate downstream of the second layer and designed to substantially stop flow of material from the second layer within the spacer layer to provide added mixing and incubation time for formation of the complex. In another embodiment, an extraction layer is on the substrate downstream of the first layer and upstream of the second layer. Methods of use are also disclosed.
FILED Friday, May 21, 2021
APPL NO 17/326472
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/82 (20130101)
G01N 33/558 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278450 Muthuswamy
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Jitendran Muthuswamy (Chandler, Arizona)
ASSIGNEE(S) Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S) Jitendran Muthuswamy (Chandler, Arizona)
ABSTRACT Systems and methods to determine an electrochemical impedance spectrogram (EIS) rapidly in real time are provided. Embodiments described herein provide an approach to determine an EIS rapidly (e.g., much less than one second) over a wide band of frequencies. Since the EIS is a foundational diagnostic that is used in a wide variety of applications involving electrochemical events, the proposed approach will significantly impact a wide range of applications. Novel waveforms and systems analysis techniques are used to determine the electrochemical impedance over a wide range of frequencies simultaneously. Embodiments can be readily integrated into conventional electrochemical workstations and embedded devices. Other embodiments can be instantiated into custom-made hardware depending on the needs of a given application. The speed and resolution of the EIS obtained using this approach can be tailored to a wide variety of applications.
FILED Tuesday, March 09, 2021
APPL NO 17/196324
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 27/08 (20130101) Original (OR) Class
G01R 31/389 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278549 Kassas et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Zak M. Kassas (Irvine, California);  Mahdi Maaref (Irvine, California);  Joe Khalife (Cossta Mesa, California)
ABSTRACT A vehicular simultaneous localization and mapping may fuse lidar data and pseudoranges extracted from ambient cellular LTE towers. An ICP algorithm may be used to extract odometry measurements from successive lidar scans. A robust and computationally efficient feature extraction method may be used to detect edge lines and feature points from the lidars point cloud. Then, a point registration technique using a maximum likelihood approach allows the estimation of the covariance of the odometry error, which is used in EKF propagation. The proposed approach consists of a mapping mode when GNSS signals are available and subsequently a SLAM mode when GNSS signals become unavailable. The cellular transmitters states, namely position and clock bias and clock drift, are continuously estimated in both modes. Simulation and experimental results validate the accuracy of these systems and methods, and provides lane-level localization without GNSS signals.
FILED Friday, August 23, 2019
APPL NO 17/270763
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 17/89 (20130101)
G01S 19/485 (20200501) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278656 Simpson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Garth Jason Simpson (West Lafayette, Indiana);  James Ulcickas (West Lafayette, Indiana);  Fengyuan Deng (Watertown, Massachusetts);  Changqin Ding (West Lafayette, Indiana)
ABSTRACT A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a micro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.
FILED Tuesday, May 18, 2021
APPL NO 17/322903
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/21 (20130101)

Optical Elements, Systems, or Apparatus
G02B 21/06 (20130101)
G02B 21/26 (20130101)
G02B 21/367 (20130101) Original (OR) Class

Image Data Processing or Generation, in General
G06T 5/005 (20130101)
G06T 2207/10056 (20130101)
G06T 2207/20212 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279090 Hu et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) The Research Foundation for The State University of New York (Binghamton, New York)
ASSIGNEE(S)
INVENTOR(S) Yaohui Hu (Binghamton, New York);  Kartik Gopalan (Vestal, New York)
ABSTRACT Standard nested virtualization allows a hypervisor to run other hypervisors as guests, i.e. a level-0 (L0) hypervisor can run multiple level-1 (L1) hypervisors, each of which can run multiple level-2 (L2) virtual machines (VMs), with each L2 VM is restricted to run on only one L1 hypervisor. Span provides a Multi-hypervisor VM in which a single VM can simultaneously run on multiple hypervisors, which permits a VM to benefit from different services provided by multiple hypervisors that co-exist on a single physical machine. Span allows (a) the memory footprint of the VM to be shared across two hypervisors, and (b) the responsibility for CPU and I/O scheduling to be distributed among the two hypervisors. Span VMs can achieve performance comparable to traditional (single-hypervisor) nested VMs for common benchmarks.
FILED Tuesday, May 11, 2021
APPL NO 17/316990
CURRENT CPC
Electric Digital Data Processing
G06F 9/45558 (20130101) Original (OR) Class
G06F 2009/4557 (20130101)
G06F 2009/45579 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279123 Hu et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Yu Charlie Hu (West Lafayette, Indiana);  Abhilash Jindal (West Lafayette, Indiana);  Samuel Midkiff (West Lafayette, Indiana);  Abhinav Pathak (San Jose, California)
ABSTRACT Embodiments of the present invention provide a system and methods for detecting power bugs. In one embodiment, a computer-implemented method for analyzing a computer code includes generating a control flow graph for at least a portion of the computer code at a processor. The method further includes identifying power bugs by traversing the control flow graph if the control flow graph exits without performing a function call to deactivate power to any component of a device configured to execute computer executable instructions based on the computer code after performing a function call to activate power.
FILED Monday, October 19, 2020
APPL NO 17/074611
CURRENT CPC
Electric Digital Data Processing
G06F 1/28 (20130101)
G06F 1/3296 (20130101)
G06F 8/20 (20130101)
G06F 8/433 (20130101)
G06F 11/079 (20130101)
G06F 11/0742 (20130101) Original (OR) Class
G06F 11/0751 (20130101)
G06F 11/0793 (20130101)
G06F 11/3466 (20130101)
G06F 11/3604 (20130101)
G06F 11/3608 (20130101)
G06F 11/3636 (20130101)
G06F 11/3664 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279338 Bowman et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
National Science Foundation (NSF)
APPLICANT(S) The George Washington University (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Benjamin Bowman (Kensington, Maryland);  H. Howie Huang (McLean, Virginia)
ABSTRACT The graph-based source code vulnerability detection system that uses a code-similarity style technique to identify highly modified vulnerable code clones while remaining generic to all vulnerability types. The system abstracts vulnerabilities in source code to the graph domain, allowing it to identify key relationships between textual elements that are not directly discernible from the text alone. Additionally, the system analyzes the patched code in addition to the vulnerable code to identify specific relationships in the graph that are tied directly to the vulnerable code segment, the patched code segment, and the contextual code of a particular vulnerability. By separating the vulnerability representation into these three components, a matching algorithm identifies vulnerable code clones while tolerating modifications at each level independently, providing more robust detection of modified vulnerable code clones.
FILED Thursday, March 04, 2021
APPL NO 17/192249
CURRENT CPC
Electric Digital Data Processing
G06F 8/71 (20130101)
G06F 8/75 (20130101)
G06F 16/9024 (20190101)
G06F 21/577 (20130101) Original (OR) Class
G06F 2221/033 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279369 Beigi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
APPLICANT(S) Ghazaleh Beigi (Tempe, Arizona);  Ruocheng Guo (Mianyang, China PRC);  Huan Liu (Tempe, Arizona);  Yanchao Zhang (Phoenix, Arizona);  Alexander Nou (Mesa, Arizona)
ASSIGNEE(S)
INVENTOR(S) Ghazaleh Beigi (Tempe, Arizona);  Ruocheng Guo (Mianyang, China PRC);  Huan Liu (Tempe, Arizona);  Yanchao Zhang (Phoenix, Arizona);  Alexander Nou (Mesa, Arizona)
ABSTRACT Systems and methods of privacy protection of a user may include compiling an actual number of links in a web history corresponding to each topic in a plurality of internet topics; compiling a topic probability distribution based on the web history; determining an additional number of links to be added to each topic in the plurality of internet topics; and modifying the topic probability distribution by selecting a set of links corresponding to the additional number of links for each topic in the plurality of internet topics.
FILED Wednesday, February 05, 2020
APPL NO 16/782349
CURRENT CPC
Electric Digital Data Processing
G06F 16/9536 (20190101)
G06F 16/9558 (20190101)
G06F 21/6263 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279631 Pichler et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Physics (PHY)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Hannes Pichler (Cambridge, Massachusetts);  Shengtao Wang (Somerville, Massachusetts);  Leo Xiangyu Zhou (Somerville, Massachusetts);  Soonwon Choi (El Cerrito, California);  Mikhail D. Lukin (Cambridge, Massachusetts)
ABSTRACT Systems and methods relate to selectively arranging a plurality of qubits into a spatial structure to encode a quantum computing problem. Exemplary arrangement techniques can be applied to encode various quantum computing problems. The plurality of qubits can be driven according to various driving techniques into a final state. The final state can be measured to identify an exact or approximate solution to the quantum computing problem.
FILED Friday, August 30, 2019
APPL NO 17/270741
CURRENT CPC
Optical Computing Devices;
G06E 1/00 (20130101)

Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279641 Konar et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S) Megan Konar (Champaign, Illinois);  Xiaowen Lin (Sunnyvale, California)
ABSTRACT Embodiments described herein relate to training, by a computing system, a gamma mixture hurdle model. The model may characterize a functional relationship between: output data specifying food flows between zones, and input variables representing food production and food consumption in the zones. The training involves: (i) using binary logistic regression to estimate whether corresponding food flows exist between zone pairs, and (ii) for pairs in which corresponding food flows exist, using a gamma mixture model to estimate amounts of the corresponding food flows. Based on the gamma mixture hurdle model, the computing system can estimate, where each zone includes a respective set of regions: (i) whether corresponding food sub-flows exist between region pairs, and (ii) for pairs in which the corresponding food sub-flows are estimated to exist, potentials of the corresponding food sub-flows. The computing system can also determine, using a linear programming framework, values for the corresponding food sub-flows.
FILED Friday, March 05, 2021
APPL NO 17/193229
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 5/027 (20130101)
G06N 7/005 (20130101)
G06N 20/00 (20190101) Original (OR) Class

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/06315 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279876 GRIER et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)
INVENTOR(S) David G. GRIER (New York, New York);  Fook Chiong CHEONG (Brooklyn, New York);  Kaitlynn SNYDER (New York, New York);  Rushna QUADDUS (New York, New York);  Lauren E. ALTMAN (New York, New York);  Kent KIRSHENBAUM (New York, New York)
ABSTRACT An in-line holographic microscope can be used to analyze a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. An assay using the holographic microscope for holographic particle characterization directly detect viruses, antibodies and related targets binding to the surfaces of specifically functionalized micrometer-scale colloidal probe beads. The system detects binding of targets by directly measuring associated changes in the bead's diameter without the need for downstream labeling and analysis.
FILED Tuesday, March 09, 2021
APPL NO 17/196895
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1434 (20130101)
G01N 2015/1445 (20130101)

Optical Elements, Systems, or Apparatus
G02B 21/365 (20130101)

Holographic Processes or Apparatus
G03H 1/0005 (20130101)
G03H 1/0465 (20130101)
G03H 2001/005 (20130101)
G03H 2001/0471 (20130101)
G03H 2210/55 (20130101)
G03H 2222/13 (20130101)
G03H 2222/34 (20130101)

Image Data Processing or Generation, in General
G06T 7/0014 (20130101) Original (OR) Class
G06T 7/62 (20170101)
G06T 2207/10056 (20130101)
G06T 2207/30024 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280685 Das et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Sandia National Laboratories (SNL)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) Kansas State University Research Foundation (Manhattan, Kansas);  Purdue Research Foundation (West Lafayatte, Indiana)
ASSIGNEE(S)
INVENTOR(S) Suprem R. Das (Manhattan, Kansas);  David B. Janes (West Lafayette, Indiana);  Jiseok Kwon (Lafayette, Indiana)
ABSTRACT A semiconductor device and methods of fabricating and using the same are provided. The semiconductor device comprises a channel region and at least a first, second, and third electrode. The channel region includes a compound having a transition metal and a chalcogen. The thickness of the channel region is about 3 to about 40 atomic layers.
FILED Saturday, June 22, 2019
APPL NO 17/253180
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/02568 (20130101)
H01L 29/24 (20130101)
H01L 29/435 (20130101) Original (OR) Class
H01L 29/7606 (20130101)
H01L 29/66969 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280765 Huang
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (Tuscaloosa, Alabama)
ASSIGNEE(S)
INVENTOR(S) Qiang Huang (Tuscaloosa, Alabama)
ABSTRACT A carrier is provided for quantum computer chips that allows easy implementation, connection, and communication to and from the quantum computer chips while minimizing the thermal perturbation and avoiding labor intensive manual connection as well as the human error in such manual connection. Methods for fabricating such carriers are also provided.
FILED Wednesday, December 23, 2020
APPL NO 17/132032
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101)

Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties
H01B 12/14 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 39/06 (20130101)
H01L 39/24 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280772 EOM et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
National Science Foundation (NSF)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Chang-Beom EOM (Madison, Wisconsin);  Tianxiang NAN (Ithaca, New York);  Jonathon SCHAD (Madison, Wisconsin)
ABSTRACT Voltage-controlled spin field effect transistors (“spin transistors”) and methods for their use in switching applications are provided. In the spin transistors, spin current is transported from a spin injection contact to a spin detection contact through a multiferroic antiferromagnetic channel via magnon propagation. The spin current transport is modulated by the application of a gate voltage that increases the number of domain boundaries the multiferroic antiferromagnetic material.
FILED Thursday, March 05, 2020
APPL NO 16/809970
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/22 (20130101)
H01L 29/78 (20130101)
H01L 29/82 (20130101)
H01L 43/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280775 BUHRMAN et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
National Nanotechnology Coordinated Infrastructure (NNCI)
Office of the Director of National Intelligence (ODNI)
Intelligence Advanced Research Projects Activity (IARPA)
APPLICANT(S) Cornell University (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Robert A. BUHRMAN (Ithaca, New York);  Lijun ZHU (Ithaca, New York)
ABSTRACT Methods, systems, and devices are disclosed for enhancement of spin-orbit torque. In one aspect, a magnetic device includes a magnetic tunneling junction (MTJ), including a free magnetic layer, a pinned magnetic layer and a non-magnetic junction layer between the free magnetic layer and the pinned magnetic layer, and a spin Hall effect metal layer that includes one or more insertion metal layers operable to introduce interfacial scattering of electrons flowing in the spin Hall metal layer to increase the spin current that interacts with and changes the magnetization of the free magnetic layer of the MTJ.
FILED Monday, March 16, 2020
APPL NO 16/820496
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 43/04 (20130101) Original (OR) Class
H01L 43/06 (20130101)
H01L 43/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280852 Takeuchi et al.
FUNDED BY
Department of Energy (DOE)
Brookhaven National Laboratory (BNL)
Brookhaven Science Associates, LLC (BSA)
Office of Energy Efficiency and Renewable Energy (EERE)
National Science Foundation (NSF)
APPLICANT(S) THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York);  BROOKHAVEN SCIENCE ASSOCIATES, LLC (Upton, New York)
ASSIGNEE(S) The Research Foundation For The State University of New York (Albany, New York);  Brookhaven Science Associates, LLC (Upton, New York)
INVENTOR(S) Esther S. Takeuchi (South Setauket, New York);  Amy C. MARSCHILOK (Stony Brook, New York);  Kenneth TAKEUCHI (South Setauket, New York);  David C. BOCK (Moriches, New York)
ABSTRACT An anode configured for fast charging a lithium-ion battery includes an anode substrate and a coating provided on a surface of the anode substrate for increasing an overpotential of Li metal to inhibit Li metal plating during extreme fast charging a lithium-ion battery fabricated with the anode. The anode is fabricated by a process of applying a coating to the anode substrate surface that comprises a nanolayer of Cu, or a nanolayer of Ni or a composite nanolayer of Cu and Ni.
FILED Friday, January 18, 2019
APPL NO 16/962970
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/133 (20130101)
H01M 4/366 (20130101) Original (OR) Class
H01M 10/0525 (20130101)
H01M 2004/027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210281241 Safavi-Naeini et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Amir H. Safavi-Naeini (Palo Alto, California);  Marek Pechal (Zurich, Switzerland);  Patricio Arrangoiz-Arriola (Menlo Park, California);  Edward Alexander Wollack (Clarksville, Maryland)
ABSTRACT A coupled storage qubit nanomechanical resonator in a processing qubit superconducting circuit is provided that includes a phononic crystal resonator (PCR) film disposed on a substrate, where the PCR film includes a defect mode in a bandgap of the PCR film where a storage qubit is encoded, a pair of electrodes generate voltages within the PCR film, where the defect is dimensioned to support a unique electrical potential generated by a local mechanical phonon mode of the PCR film, where a unique resonance frequency that is dependent on the defect dimensions is output from the PCR film, a coupling capacitor that is coupled to the PCR film, where the coupling capacitor is disposed to receive the output unique resonance frequency, and a processing qubit, where the processing qubit is capacitively coupled to the PCR film by the coupling capacitor, where the storage qubits are connected to the processing qubits.
FILED Monday, August 26, 2019
APPL NO 16/551004
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101)

Impedance Networks, e.g Resonant Circuits; Resonators
H03H 9/24 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210281304 Paramesh et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Jeyanandh Paramesh (Pittsburgh, Pennsylvania);  Susnata Mondal (Pittsburgh, Pennsylvania)
ABSTRACT Designs and techniques to enhance power-efficiency and incorporate new features in millimeter-wave MIMO transceivers are described. A new mechanism for built-in dual-band, per-element self-interference cancellation (SIC) is introduced to enable multi-antenna frequency-division duplex (FDD) and full-duplex (FD) operation. Additionally, several innovative circuit concepts are introduced, including low-loss wideband antenna interface design, dual-band power combining PA, dual-band RF-SIC design, and bi-directional MIMO signal
FILED Wednesday, May 12, 2021
APPL NO 17/318757
CURRENT CPC
Antennas, i.e Radio Aerials
H01Q 1/523 (20130101)
H01Q 3/38 (20130101)
H01Q 21/0025 (20130101)

Transmission
H04B 1/40 (20130101)
H04B 7/0413 (20130101)
H04B 7/0617 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 20210275457 JOHNSTON et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Keith P. JOHNSTON (Austin, Texas);  Joshua ENGSTROM (Spotswood, New Jersey);  Robert O. WILLIAMS, III (Austin, Texas)
ABSTRACT The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.
FILED Thursday, January 21, 2021
APPL NO 17/154610
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/1658 (20130101)
A61K 9/1682 (20130101) Original (OR) Class

Separation
B01D 9/005 (20130101)

Technical Subjects Covered by Former US Classification
Y10T 428/2982 (20150115)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276594 OH et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Geunseob OH (Ann Arbor, Michigan);  Huei PENG (Ann Arbor, Michigan)
ABSTRACT A system and method for determining a predicted trajectory of a human-driven host vehicle as the human-driven host vehicle approaches a traffic signal. The method includes: obtaining a host vehicle-traffic light distance dx and a longitudinal host vehicle speed vx that are each taken when the human-driven host vehicle approaches the traffic signal; obtaining a traffic light signal phase Pt and an traffic light signal timing Tt; obtaining a time of day TOD; providing the host vehicle-traffic light distance dx, the longitudinal host vehicle speed vx, the traffic light signal phase Pt, the traffic light signal timing Tt, and the time of day TOD as input into an artificial intelligence (AI) vehicle trajectory prediction application, wherein the AI vehicle trajectory prediction application implements an AI vehicle trajectory prediction model; and determining the predicted trajectory of the human-driven host vehicle using the AI vehicle trajectory prediction application.
FILED Friday, January 15, 2021
APPL NO 17/150690
CURRENT CPC
Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit
B60W 40/04 (20130101)
B60W 60/0027 (20200201) Original (OR) Class
B60W 2554/80 (20200201)
B60W 2554/4042 (20200201)
B60W 2554/4045 (20200201)
B60W 2556/65 (20200201)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)

Wireless Communication Networks
H04W 4/44 (20180201)
H04W 4/46 (20180201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276969 DZWINIEL et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Trevor L. DZWINIEL (Carol Stream, Illinois);  Krzysztof PUPEK (Plainfield, Illinois)
ABSTRACT In one embodiment, a continuous process for preparing organic carbonate solvent of Formula (I) as described herein comprises contacting a first reactant (an alcohol) with a reactive carbonyl source (carbonyldiimidazole (CDI) or an alkylchloroformate) in the presence of a catalyst in reaction stream flowing through a continuous flow reactor at temperature 20° C. to about 160° C. and at a flow rate providing a residence time in the range of about 0.1 minute to about 24 hours; collecting a reactor effluent exiting from the continuous flow reactor; recovering a crude product from the reactor effluent; and distilling the crude product to obtain the organic carbonate compound of Formula (I). In another embodiment, the first reactant is an epoxide and the carbonyl source is carbon dioxide.
FILED Tuesday, March 23, 2021
APPL NO 17/209742
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 31/0232 (20130101)

Acyclic or Carbocyclic Compounds
C07C 69/96 (20130101)

Heterocyclic Compounds
C07D 317/40 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277065 HAYNES et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Laboratory (LANL)
Los Alamos National Security, LLC (LANS)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Duke University (Durham, North Carolina);  Los Alamos National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Barton F. HAYNES (Durham, North Carolina);  Mattia BONSIGNORI (Durham, North Carolina);  Hua-Xin LIAO (Durham, North Carolina);  Bette T. KORBER (Los Alamos, New Mexico);  Peter T. HRABER (Los Alamos, New Mexico);  Kevin O. SAUNDERS (Durham, North Carolina)
ABSTRACT In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
FILED Thursday, March 11, 2021
APPL NO 17/199319
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/21 (20130101)
A61K 39/39 (20130101)
A61K 45/06 (20130101)
A61K 2039/545 (20130101)

Peptides
C07K 14/005 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277252 MONICKAM et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Office of Science (DOEOS)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) PIXELLIGENT TECHNOLOGIES LLC (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Selina MONICKAM (Takoma Park, Maryland);  Darryl PETERS (, None);  Gregory COOPER (Fulton, Maryland);  Zhiyun CHEN (Olney, Maryland);  Robert SWISHER (Baltimore, Maryland)
ABSTRACT The present disclosure provides a high refractive index acrylic formulation embedded with sub-10 nm metal oxide nanocrystals. The formulation is ideal for high refractive index, high transparency coating for a variety of optical applications including OLED lighting.
FILED Friday, May 14, 2021
APPL NO 17/321289
CURRENT CPC
Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/22 (20130101)
C08K 9/04 (20130101)
C08K 9/06 (20130101)

Compositions of Macromolecular Compounds
C08L 33/06 (20130101)
C08L 33/10 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 5/004 (20130101) Original (OR) Class
C09D 7/20 (20180101)
C09D 7/62 (20180101)
C09D 7/67 (20180101)
C09D 11/033 (20130101)
C09D 11/037 (20130101)
C09D 11/101 (20130101)
C09D 11/107 (20130101)
C09D 135/02 (20130101)

Optical Elements, Systems, or Apparatus
G02B 1/111 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/5268 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277263 Fenn et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
UT-Battelle, LLC (UT-BATTELLE)
Oak Ridge National Laboratory (ORNL)
APPLICANT(S) PPG Industries Ohio, Inc. (Cleveland, Ohio);  UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) David R. Fenn (Allison Park, Pennsylvania);  Kurt G. Olson (Gibsonia, Pennsylvania);  Reza M. Rock (Pittsburgh, Pennsylvania);  Cynthia Kutchko (Pittsburgh, Pennsylvania);  Susan F. Donaldson (Allison Park, Pennsylvania);  Hao Sun (Allison Park, Pennsylvania);  Orlando Rios (Knoxville, Tennessee);  William G. Carter (Oak Ridge, Tennessee)
ABSTRACT Methods of printing a three-dimensional object using co-reactive components are disclosed. Thermosetting compositions for three-dimensional printing are also enclosed.
FILED Monday, March 15, 2021
APPL NO 17/201731
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/112 (20170801)

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2075/02 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 70/00 (20141201)
B33Y 80/00 (20141201)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 18/10 (20130101)
C08G 18/73 (20130101)
C08G 18/325 (20130101)
C08G 18/755 (20130101)
C08G 18/792 (20130101)
C08G 18/3225 (20130101)
C08G 18/3228 (20130101)
C08G 18/3234 (20130101)
C08G 18/3821 (20130101)
C08G 18/4854 (20130101)
C08G 18/5024 (20130101)
C08G 18/7893 (20130101)
C08G 2150/50 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/36 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 11/03 (20130101)
C09D 11/30 (20130101)
C09D 11/38 (20130101)
C09D 11/102 (20130101) Original (OR) Class
C09D 175/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277304 Hubbard et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
Pacific Northwest National Laboratory (PNNL)
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Lance R. Hubbard (Richland, Washington);  Ryan I. Sumner (Richland, Washington);  Nicolas E. Uhnak (Kennewick, Washington);  April J. Carman (Richland, Washington);  Martin Liezers (Richland, Washington)
ABSTRACT Ruggedized luminescent nanoparticle tracers have luminescent nanoparticle cores coupled to a luminescent substrate. The substrate is a large-particle size phosphor, while the nanoparticles are photoluminescent quantum dots (QDs) whose emission spectra can be tuned based on their chemical composition, size, and fabrication (e.g., dopants). The QDs are encapsulated by a protective layer to form a nanoparticle core. The protective layer can shield the QDs from external environments that would otherwise damage the delicate QDs. The substrate is also encapsulated by a protective layer, and the protective layer of the nanoparticle core is coupled to the protective layer of the substrate via a molecular linker to form a tracer particle complex. The tracer particle complexes can be disposed in a silicate suspension for subsequent use.
FILED Wednesday, January 20, 2021
APPL NO 17/153178
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 20/00 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/025 (20130101) Original (OR) Class
C09K 11/565 (20130101)
C09K 11/574 (20130101)
C09K 11/662 (20130101)
C09K 11/883 (20130101)
C09K 11/7745 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6428 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277343 HARRISON et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
U.S. Agency for International Development (USAID)
Bureau for Economic Growth, Education, and Environment (EGEE)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Kevin William HARRISON (Erie, Colorado);  Nancy Sue FARMER (Arvada, Colorado)
ABSTRACT Systems, methods and devices for the production of renewable natural gasses are provided.
FILED Monday, July 22, 2019
APPL NO 17/261473
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 21/04 (20130101) Original (OR) Class
C12M 43/06 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 5/023 (20130101)

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 1/04 (20130101)
C25B 9/05 (20210101)
C25B 9/73 (20210101)
C25B 15/083 (20210101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277368 McGarry, JR. et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
APPLICANT(S) Battelle Memorial Institute (Columbus, Ohio);  The Ohio State University (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Kevin G. McGarry, JR. (Delaware, Ohio);  Robert A. Moyer (Plain City, Ohio);  David W. Wood (Dublin, Ohio)
ABSTRACT Disclosed herein are proteins having at least 90% sequence identity to a wild-type human butyrylcholinesterase and compositions comprising same. The disclosed proteins may have at least one mutation at a position within the acyl binding pocket and at least one mutation adjacent to the acyl biding pocket. Further disclosed are proteins having at least 90% sequence identity to a wild-type human butyrylcholinesterase, wherein the protein may comprise a mutation at a position selected from one or more of 282, 283, and 284.
FILED Thursday, February 06, 2020
APPL NO 16/783383
CURRENT CPC
Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/20 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/18 (20130101) Original (OR) Class

Enzymes
C12Y 301/01008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277531 Allanore et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Antoine Allanore (Brentwood, New Hampshire);  Caspar R. Stinn (Magnolia, Texas)
ABSTRACT Various embodiments utilize selective sulfidation and/or desulfidation for such things as ore and concentrate cracking, metal separation, compound production, and recycling. Selective sulfidation can be used to selectively convert an oxide or other material in a feedstock to a sulfide or other sulfur-containing material, and selective desulfidation can be used to selectively convert a sulfide or other sulfur-containing material in a feedstock to an oxide or other material. In some cases, the material produced by such selective sulfidation/desulfidation of the feedstock can itself be novel and/or commercially valuable, while in other cases, such selective sulfidation/desulfidation can be followed by one or more processes to extract, isolate, or concentrate the converted material.
FILED Sunday, December 27, 2020
APPL NO 17/134429
CURRENT CPC
Production and Refining of Metals; Pretreatment of Raw Materials
C22B 1/06 (20130101)
C22B 1/11 (20130101)
C22B 26/20 (20130101)
C22B 59/00 (20130101)

Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor
C25C 3/02 (20130101) Original (OR) Class
C25C 3/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277776 Pasumarti et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
APPLICANT(S) Battelle Memorial Institute (Columbus, Ohio)
ASSIGNEE(S) Battelle Memorial Institute (Columbus, Ohio)
INVENTOR(S) Ashwin Pasumarti (King of Prussia, Pennsylvania);  Joel Sminchak (Columbus, Ohio);  Mark Moody (Columbus, Ohio)
ABSTRACT Described herein is a method and techniques for subsurface monitoring. The system includes a downhole including a casting with a lumen, a wireless power transmitter within the casting, a micro-sensor cement mixture including a plurality of micro-sensors mixed with a cement, the micro-sensor cement mixture on a surface of the casting opposite from the lumen, a relay system including a plurality of relays, each of the plurality of relays including a charging component and a surface receiver. The wireless power transmitter configured to transmit a wireless power signal. At least one micro-sensor of the plurality of micro-sensors is configured to receive the wireless power signal, sense at least one attribute, and transmit a sensed signal. A series of relays are configured to receive the sensed signal and re-transmit the sensed signal and a surface receiver is configured to receive the sensed signal at a third time after the second time.
FILED Friday, March 05, 2021
APPL NO 17/193768
CURRENT CPC
Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 47/01 (20130101)
E21B 47/13 (20200501) Original (OR) Class

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 50/80 (20160201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278147 France et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) David M. France (Lombard, Illinois);  Dileep Singh (Naperville, Illinois);  Wenhua Yu (Darien, Illinois)
ABSTRACT A heat exchanger adapted to receive high temperature, high pressure, and corrosive fluids including a body having an interior volume, a first set of channels extending through the body, a second set of channels extending through the body, a first set of headers, and a second set of headers. Each channel in the first set of channels having a first inlet aperture, a first inlet portion, a first outlet aperture, a first outlet portion, and a first conduit extending between the first inlet portion and the first outlet portion. Each channel in the second set of channels having a second inlet aperture, a second inlet portion, a second outlet aperture, a second outlet portion, and a second conduit extending between the second inlet portion and the second outlet portion. The first and second conduits having a uniform shape along its length.
FILED Thursday, March 05, 2020
APPL NO 16/810428
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 1/0059 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 80/00 (20141201)

Details of Heat-exchange and Heat-transfer Apparatus, of General Application
F28F 1/10 (20130101)
F28F 9/027 (20130101) Original (OR) Class
F28F 21/04 (20130101)
F28F 21/08 (20130101)

Image Data Processing or Generation, in General
G06T 17/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278374 Ely
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
Sandia National Laboratories (SNL)
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) George Ray Ely (Albuquerque, New Mexico)
ABSTRACT A structure includes a substrate and a coating applied over the substrate, the coating containing particles sized between 30 and 250 micrometers. A proportion of the particles to the carrier is between 40 and 70 by volume percentage. In response to excitation of the structure by a controllable excitation source, a first instrument monitors behavior of the particles to determine a first condition of the structure thereby. In response to an absence of excitation of the structure by the controllable excitation source, a second instrument monitors behavior of the particles to determine a second condition of the structure thereby.
FILED Tuesday, May 18, 2021
APPL NO 17/323148
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 25/20 (20130101)
G01N 29/043 (20130101) Original (OR) Class
G01N 29/045 (20130101)
G01N 2291/0231 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279054 Kotra et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
Lawrence Livermore National Laboratory (LLNL)
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) Jagadish B. Kotra (Austin, Texas);  John Kalamatianos (Boxborough, Massachusetts)
ABSTRACT Systems, apparatuses, and methods for compacting multiple groups of micro-operations into individual cache lines of a micro-operation cache are disclosed. A processor includes at least a decode unit and a micro-operation cache. When a new group of micro-operations is decoded and ready to be written to the micro-operation cache, the micro-operation cache determines which set is targeted by the new group of micro-operations. If there is a way in this set that can store the new group without evicting any existing group already stored in the way, then the new group is stored into the way with the existing group(s) of micro-operations. Metadata is then updated to indicate that the new group of micro-operations has been written to the way. Additionally, the micro-operation cache manages eviction and replacement policy at the granularity of micro-operation groups rather than at the granularity of cache lines.
FILED Wednesday, May 19, 2021
APPL NO 17/325067
CURRENT CPC
Electric Digital Data Processing
G06F 9/223 (20130101) Original (OR) Class
G06F 9/3016 (20130101)
G06F 12/0875 (20130101)
G06F 2212/452 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279433 KAN et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S) Cornell University (Ithaca, New York)
INVENTOR(S) Edwin C. KAN (Ithaca, New York);  Xiaonan HUI (Ithaca, New York)
ABSTRACT The present disclosure provides collaborative radiofrequency identification (RFID) readers that employ code division multiple access (CDMA) encoding to simultaneously broadcast to and read responses from tags in an overlapping reading zone with improved data synchronization and read yield rates. In some embodiments, a harmonic backscattering scheme is used to enable the system to have a much higher signal-to-noise ratio (SNR) and sensitivity, while the reader CDMA protocol can be integrated with an initial TDMA polling process or alternative tag CDMA scheme.
FILED Tuesday, May 14, 2019
APPL NO 17/055974
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 7/10019 (20130101) Original (OR) Class
G06K 19/0724 (20130101)

Transmission
H04B 5/0031 (20130101)
H04B 5/0037 (20130101)
H04B 7/216 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279885 Wantuch et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
Sandia National Laboratories (SNL)
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Andrew C. Wantuch (Albuquerque, New Mexico);  Kyle Saxberg (Mountain View, California);  Edward Steven Jimenez, JR. (Albuquerque, New Mexico);  Jaxon Gittinger (Albuquerque, New Mexico);  Srivathsan Koundinyan (Bordentown, New Jersey)
ABSTRACT Illustrative embodiments are directed to a method and apparatus for evaluating boundary detection in an image. A processed image is received, wherein a detected boundary of an image of an object is identified in the processed image. A Radon transform is applied to the processed image for a plurality of angles to form a processed image histogram corresponding to the detected boundary for each of the plurality of angles. The processed image histogram for each of the plurality of angles and a corresponding ground truth histogram for each of the plurality of angles is normalized to provide a normalized processed image histogram and a normalized ground truth histogram for each of the plurality of angles, wherein the ground truth histogram corresponds to a ground truth boundary of the object for a corresponding angle. An indication of the edges of the normalized processed image histogram for each of the plurality of angles is plotted to form a boundary detection evaluation visualization.
FILED Tuesday, May 18, 2021
APPL NO 17/323214
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/13 (20170101) Original (OR) Class
G06T 7/162 (20170101)
G06T 7/168 (20170101)
G06T 2207/10012 (20130101)
G06T 2207/20072 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280685 Das et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Sandia National Laboratories (SNL)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) Kansas State University Research Foundation (Manhattan, Kansas);  Purdue Research Foundation (West Lafayatte, Indiana)
ASSIGNEE(S)
INVENTOR(S) Suprem R. Das (Manhattan, Kansas);  David B. Janes (West Lafayette, Indiana);  Jiseok Kwon (Lafayette, Indiana)
ABSTRACT A semiconductor device and methods of fabricating and using the same are provided. The semiconductor device comprises a channel region and at least a first, second, and third electrode. The channel region includes a compound having a transition metal and a chalcogen. The thickness of the channel region is about 3 to about 40 atomic layers.
FILED Saturday, June 22, 2019
APPL NO 17/253180
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/02568 (20130101)
H01L 29/24 (20130101)
H01L 29/435 (20130101) Original (OR) Class
H01L 29/7606 (20130101)
H01L 29/66969 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280725 HAN et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Department of Energy (DOE)
APPLICANT(S) UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico);  AIR FORCE RESEARCH LAB (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Sang M. HAN (Albuquerque, New Mexico);  Omar Kamal ABUDAYYEH (Albuquerque, New Mexico);  Andre CHAVEZ (Albuquerque, New Mexico);  David M. WILT (Albuquerque, New Mexico)
ABSTRACT A metal matrix composite paste is provided for screen printing metal matrix composite contacts in a photovoltaic cell. The metal matrix composite paste includes a plurality of functionalized multi-walled carbon nanotubes in a metal paste. Because the metal matrix composite paste can have similar mechanical and chemical properties to a metal paste, it can be incorporated into standard metallization processes. The metal matrix composite contacts formed from the metal matrix composite paste can have increased ductility and self-healing capability to electrically bridge a gap caused by physical fracture of a busbar or gridline.
FILED Friday, June 28, 2019
APPL NO 17/257607
CURRENT CPC
Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties
H01B 1/04 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/18 (20130101)
H01L 31/02168 (20130101)
H01L 31/022425 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280852 Takeuchi et al.
FUNDED BY
Department of Energy (DOE)
Brookhaven National Laboratory (BNL)
Brookhaven Science Associates, LLC (BSA)
Office of Energy Efficiency and Renewable Energy (EERE)
National Science Foundation (NSF)
APPLICANT(S) THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (Albany, New York);  BROOKHAVEN SCIENCE ASSOCIATES, LLC (Upton, New York)
ASSIGNEE(S) The Research Foundation For The State University of New York (Albany, New York);  Brookhaven Science Associates, LLC (Upton, New York)
INVENTOR(S) Esther S. Takeuchi (South Setauket, New York);  Amy C. MARSCHILOK (Stony Brook, New York);  Kenneth TAKEUCHI (South Setauket, New York);  David C. BOCK (Moriches, New York)
ABSTRACT An anode configured for fast charging a lithium-ion battery includes an anode substrate and a coating provided on a surface of the anode substrate for increasing an overpotential of Li metal to inhibit Li metal plating during extreme fast charging a lithium-ion battery fabricated with the anode. The anode is fabricated by a process of applying a coating to the anode substrate surface that comprises a nanolayer of Cu, or a nanolayer of Ni or a composite nanolayer of Cu and Ni.
FILED Friday, January 18, 2019
APPL NO 16/962970
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/133 (20130101)
H01M 4/366 (20130101) Original (OR) Class
H01M 10/0525 (20130101)
H01M 2004/027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280863 Liu et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Tongchao Liu (Westmont, Illinois);  Khalil Amine (Oakbrook, Illinois)
ABSTRACT A cathode active material includes a composition expressed as:
Li1+β(NixMnyCoz)M1α(Nix′Mny′Coz′)M21−αO2; or
Na1+β(NixMnyCoz)M1α(Nix′Mny′Coz′)M21−αO2; where: M1 represents a core composition comprising of Ni, Mn, and/or Co or a combination of at two of thereof; M2 represents a surface composition having at least 50% Co, and, optionally Ni and/or Mn; the structure of M2 may be a composite structure and includes a rock-salt or disordered rock-salt phase; 0.5≤α<1, 0≤x≤1, 0≤y≤0.5, 0≤z≤1, 0≤x′≤0.5, 0≤y′≤0.5, 0.5≤z′≤1, and −0.1≤β≤0.1; the sum of x, y and z is 0.9-1.1, and the sum of x′, y′ and z′ is 0.9-1.1.
FILED Wednesday, March 04, 2020
APPL NO 16/809332
CURRENT CPC
Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 53/50 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/62 (20130101)
H01M 4/366 (20130101)
H01M 4/505 (20130101) Original (OR) Class
H01M 4/525 (20130101)
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210281076 Meeker et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
ASSIGNEE(S)
INVENTOR(S) Richard H. Meeker (Tallahassee, Florida);  MD Omar Faruque (Tallahassee, Florida);  Juan Ospina (Tallahassee, Florida);  Alvi Newaz (Tallahassee, Florida);  Emmanuel Collins (Tallahassee, Florida);  Griffin Francis (Newton, Massachusetts);  Nikhil Gupta (Tallahassee, Florida)
ABSTRACT Devices and methods of allocating distributed energy resources (DERs) to loads connected to a microgrid based on the cost of the DERs are provided. The devices and methods may determine one or more microgrid measurements. The devices and methods may determine one or more real-time electricity prices associated with utility generation sources. The devices and methods may determine one or more forecasts. The devices and methods may determine a cost associated with one or more renewable energy sources within the microgrid. The devices and methods may determine an allocation of the renewable sources to one or more loads in the microgrid.
FILED Wednesday, May 19, 2021
APPL NO 17/324733
CURRENT CPC
Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 13/027 (20130101)
G05B 13/048 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/04 (20130101)
G06Q 30/0206 (20130101)
G06Q 50/06 (20130101)

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 3/003 (20200101)
H02J 3/38 (20130101) Original (OR) Class
H02J 2203/20 (20200101)

Systems Integrating Technologies Related to Power Network Operation, Communication or Information Technologies for Improving the Electrical Power Generation, Transmission, Distribution, Management or Usage, i.e Smart Grids
Y04S 50/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210281663 Edgar et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
Pacific Northwest National Laboratory (PNNL)
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Thomas W. Edgar (Richland, Washington);  Sean J. Zabriskie (Seattle, Washington);  Eric Y. Choi (Richland, Washington)
ABSTRACT Apparatuses and methods for tapping serial communications and transforming the serial data into a format appropriate for routable networks are significant for purposes of security and troubleshooting, especially in critical infrastructure networks. Communication taps should be completely passive such that any failure would not interrupt the serial communications. Furthermore, automatic determination of unspecified serial protocol frames allow general implementation across various networks, or across devices within a single network, without the need to customize for each implementation.
FILED Thursday, May 13, 2021
APPL NO 17/319420
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 63/20 (20130101)
H04L 63/30 (20130101)
H04L 69/03 (20130101) Original (OR) Class
H04L 69/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 20210274825 Ames et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) Children`s Hospital and Research Center at Oakland (Oakland, California);  The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Bruce Ames (Berkeley, California);  Mark Shigenaga (San Rafael, California);  Michele Mietus Snyder (Washington, District of Columbia);  Joyce McCann (Walnut Creek, California);  Tara McHugh (Albany, California);  Donald A. Olson (Isleton, California)
ABSTRACT The present invention provides nutritional compositions (for example, sensorially acceptable nutritional compositions) that comprise a fruit component, a fiber component, and a micronutrient component. Also provided are methods of making and using the nutritional compositions.
FILED Tuesday, May 25, 2021
APPL NO 17/330158
CURRENT CPC
Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General
A23L 19/09 (20160801)
A23L 33/12 (20160801)
A23L 33/15 (20160801)
A23L 33/16 (20160801)
A23L 33/21 (20160801)
A23L 33/30 (20160801)
A23L 33/40 (20160801) Original (OR) Class
A23L 33/105 (20160801)
A23L 33/155 (20160801)
A23L 33/175 (20160801)

Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages
A23V 2002/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275648 PEREZ DE LEON et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) ADALBERTO A PEREZ DE LEON (WAKE FOREST, North Carolina);  ROBERT E BRIGGS (BOONE, Iowa);  FRED M TATUM (NEVADA, Iowa);  Robert Miller (McAllen, Texas);  Felicito Guerrero (Kerrville, Texas)
ABSTRACT This invention relates to novel fusion peptides and immunogenic compositions containing the fusion peptides useful in the control and prevention of tick infestations. The invention also relates to compositions comprising said fusion peptides, methods of vaccination against tick infestation using said fusion peptides and compositions, and kits for use with such compositions and methods.
FILED Tuesday, March 02, 2021
APPL NO 17/190235
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/0003 (20130101) Original (OR) Class
A61K 39/08 (20130101)
A61K 2039/53 (20130101)
A61K 2039/523 (20130101)
A61K 2039/552 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 33/14 (20180101)

Peptides
C07K 14/33 (20130101)
C07K 14/43527 (20130101)
C07K 2319/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210275660 BRIGGS et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) ROBERT E BRIGGS (BOONE, Iowa);  FRED M TATUM (NEVADA, Iowa)
ABSTRACT The present invention relates to modified Mannheimia haemolytica (M. haemolytica) lktCA gene cluster cassettes, compositions comprising such cassettes, methods of using such cassettes and compositions, and kits comprising such cassettes and compositions. Also described herein are Mycoplasma bovis (M. bovis) protective antigens, compositions comprising such antigens, methods of using such antigens and compositions, and kits comprising such antigens and compositions. Also described herein are modified M. haemolytica lktCA gene cluster cassettes engineered to express M. bovis protective antigens, compositions comprising such cassettes, methods of using such cassettes and compositions, and kits comprising such cassettes and compositions.
FILED Tuesday, March 02, 2021
APPL NO 17/190182
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/04 (20130101)
A61K 39/102 (20130101) Original (OR) Class
A61K 2039/5256 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276006 Hnasko et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Robert M. Hnasko (Pinole, California);  RONALD P. HAFF (Davis, California);  ERIC S. JACKSON (Lafayette, California)
ABSTRACT The biosensor platform is a rapid point-of-care (POC) device wherein detection of a target substance is performed in a single step using a fully integrated disposable biosensor test system. In one embodiment, the system comprises a horizontally oriented multi-strip test cassette. A user initiates the test by depositing an analyte onto an immunochromatographic test strip sandwiched between a (top) cassette lid and a (bottom) slotted cassette tray. The test strip is held in place by at least one horizontally extending self-adjusting flex plate. The system is structured so that as the analyte flows through the test strip, the analyte reacts with a reagent in the test strip to indicate a presence or absence of the targeted substance as the test strip is held in place by the self-adjusting flex plate.
FILED Thursday, January 21, 2021
APPL NO 17/154539
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/5023 (20130101) Original (OR) Class
B01L 2300/0636 (20130101)
B01L 2300/0825 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/54366 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277189 BODDU et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) VEERA M. BODDU (PEORIA, Illinois);  JINGYUAN XU (DUNLAP, Illinois);  GEORGE F. FANTA (MORTON, Illinois)
ABSTRACT The present invention relates to superabsorbent biobased hydrogels prepared with sodium carboxymethyl cellulose (CMCNa) and hydroxyethyl cellulose (HEC) cross-linked with either citric acid, succinic acid, or sebacic acid. The swelling ratio of the superabsorbent hydrogels of the invention was dependent on the cross-linker used, the concentration of the cross-linker, and the cross-linking temperature.
FILED Friday, March 06, 2020
APPL NO 16/811016
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/2054 (20130101)
A61K 9/4866 (20130101)
A61K 47/38 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/24 (20130101)
B01J 20/3085 (20130101)
B01J 20/28047 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/075 (20130101) Original (OR) Class
C08J 3/247 (20130101)
C08J 2301/28 (20130101)
C08J 2401/28 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 17/32 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279857 TONG et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) University of Florida Research Foundation, Inc. (Gainesville, Florida);  Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Zhaohui TONG (Gainesville, Florida);  Hanxi BAO (Gainesville, Florida);  Guanghui LAN (Atlanta, Georgia);  Karyn E. MOSES (Gainesville, Florida)
ABSTRACT Described herein are devices for determining or monitoring the quality of a food product. In one aspect, the devices comprise a pH-sensitive film incorporated within a quick response code, wherein the pH-sensitive film is positioned to be in contact with the food product. The pH-sensitive film produces different colors subject to changes in pH of the food product. The color produced by the pH-sensitive film can then be correlated to the quality of the food product. The quick response code can provide additional information regarding the food product.
FILED Tuesday, March 02, 2021
APPL NO 17/189624
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/80 (20130101)
G01N 33/12 (20130101)
G01N 2021/7796 (20130101)
G01N 2201/129 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 19/06037 (20130101)

Image Data Processing or Generation, in General
G06T 7/0004 (20130101) Original (OR) Class
G06T 7/90 (20170101)
VIEW PATENT @ USPTO:  Full Text   PDF 

United States Postal Service (USPS) 

US 20210276800 Luckay
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Ryan M. Luckay (Vienna, Virginia)
ABSTRACT A system for loading and unloading containers of items from transport vehicles and moving containers of items to and from desired locations using automated robots are disclosed. The system includes one or more automated robots, a base station, and one or more vehicle-based systems. The automated robots are configured to move to, lift, and carry containers of items. The base station is configured to coordinate the movements of the automated robots. The vehicle-based systems are associated with transport vehicles and configured to communicate information about containers on the transport vehicles to the base station or automated robots. The vehicle-based systems may call the one or more automated robots to automatically load or unload the transport vehicles.
FILED Monday, March 01, 2021
APPL NO 17/189003
CURRENT CPC
Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors
B65G 1/0492 (20130101) Original (OR) Class
B65G 1/1371 (20130101)
B65G 1/1373 (20130101)

Systems for Controlling or Regulating Non-electric Variables
G05D 1/0274 (20130101)
G05D 2201/0216 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/087 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210277699 POTTER et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Thomas C. POTTER (Oak Hill, Virginia);  Scott R. BOMBAUGH (Burke, Virginia);  Terry M. GINGELL (Spotsylvania, Virginia);  Anthony TAYLOR (Stafford, Virginia);  Christopher M. STRATTON (Springfield, Virginia);  Benjamin SCHWIND (Falls Church, Virginia)
ABSTRACT A closure member (e.g., door) stop includes a base having a top portion opposite a bottom portion, the bottom portion being configured for affixing to an installation point associated with the closure member, a flexure extending away from the top portion, a cushion comprising an angled face and an impact face, the impact face being configured to interface with the closure member during closing of the closure member, and the angled face being configured to interface with the closure member during opening of the closure member. The flexure provides an operable, bendable connection between the cushion and the base. Also, a lever is operably connected to the cushion and the flexure and configured to move the cushion away from a swing path of the closure member. The cushion extends into a swing path of the closure member when the closure member stop is at rest in the installed position.
FILED Friday, March 05, 2021
APPL NO 17/193123
CURRENT CPC
Devices for Moving Wings into Open or Closed Position; Checks for Wings; Wing Fittings Not Otherwise Provided For, Concerned With the Functioning of the Wing
E05F 5/04 (20130101)
E05F 5/027 (20130101) Original (OR) Class
E05F 2005/046 (20130101)

Indexing Scheme Relating to Hinges or Other Suspension Devices for Doors, Windows or Wings and Devices for Moving Wings into Open or Closed Position, Checks for Wings and Wing Fittings Not Otherwise Provided For, Concerned With the Functioning of the Wing
E05Y 2201/224 (20130101)
E05Y 2900/13 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279501 SCHIMMEL et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Todd M. SCHIMMEL (Annandale, Virginia);  Ryan J. SIMPSON (Vienna, Virginia)
ABSTRACT An item measuring system and its relate processes may perform operations that include receiving an image of an item and a reference tag; identifying a perimeter of the item; identifying a type of the reference tag; identifying known dimensions of the reference tag based on the type; determining dimensions of the item in standardized units based on the known dimensions of the reference tag; and outputting information identifying the dimensions of the item.
FILED Wednesday, March 03, 2021
APPL NO 17/190476
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/52 (20130101) Original (OR) Class
G06K 19/0776 (20130101)
G06K 19/06009 (20130101)

Image Data Processing or Generation, in General
G06T 7/62 (20170101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279679 Schimmel
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Todd M. Schimmel (Annandale, Virginia)
ABSTRACT Systems and methods perform operations that include receiving information regarding an item; obtaining one or more digital images of the item; generating an image dataset, which may be unique, for the item based on the one or more digital images; storing information linking the image data set to the information regarding the item; receiving, from an item disposition system, a request to identify the item, wherein the request includes the image dataset for the item; identifying the item based on receiving the request and the image dataset; and providing, to the item disposition system, the information regarding the item to cause the item disposition system to disposition the item based on the information regarding the item.
FILED Wednesday, March 03, 2021
APPL NO 17/190489
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 7/1413 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/0833 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210280091 Simpson
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Ryan J. Simpson (Vienna, Virginia)
ABSTRACT This application relates to a method and a system for building machine learning or deep learning data sets for automatically recognizing labels on items. The system may include an optical scanner configured to capture an item including one or more labels provided thereon, the item captured a plurality of times at different positions with respect to the optical scanner. The system may further include a robotic arm on which the item is disposed, the robotic arm configured to rotate the item horizontally and/or vertically such that the one or more labels of the item are captured by the optical scanner at different positions with respect to the optical scanner. The system may include a database configured to store the captured images.
FILED Wednesday, March 03, 2021
APPL NO 17/191483
CURRENT CPC
Labelling or Tagging Machines, Apparatus, or Processes
B65C 1/02 (20130101)

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 50/26 (20130101)

Displaying; Advertising; Signs; Labels or Name-plates; Seals
G09F 3/0288 (20130101)
G09F 3/0297 (20130101) Original (OR) Class
G09F 2003/022 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 20210275329 Hansen et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Rehabilitation Research and Development Service (RR&DS)
APPLICANT(S) UNITED STATES DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia);  REGENTS OF THE UNIVERSITY OF MINNESOTA (Saint Paul, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Andrew Hansen (Minneapolis, Minnesota);  Gregory Owen Voss (Minneapolis, Minnesota);  Eric Nickel (Minneapolis, Minnesota);  Emily Hein (Minneapolis, Minnesota)
ABSTRACT Disclosed herein are devices, systems, and methods for accommodating quick and easy exchange of footwear for lower limb amputees. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
FILED Monday, June 17, 2019
APPL NO 17/253294
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/6607 (20130101) Original (OR) Class
A61F 2002/6642 (20130101)
A61F 2002/6671 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276909 Keithley et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Office of Research and Development (ORD)
Environmental Protection Agency (EPA)
APPLICANT(S) United States Government, as represented by the Administrator of the U.S. EPA (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Asher Keithley (Cincinnati, Ohio);  Daniel Williams (Fairfield, Ohio);  Nicholas Dugan (Wyoming, Ohio);  Darren Lytle (Liberty Township, Ohio)
ABSTRACT Systems and methods are provided for nitrogen gas sparging assisted biological treatment of water. In one example, a denitrification system may include a media-packed column or bed through which nitrogen gas is sparged to remove dissolved oxygen from water. In some examples, an external carbon source and electron donor may be added to the media-packed column or bed to facilitate biological removal of the nitrate and/or other contaminants from the water. In this way, by relying on the sparged nitrogen gas to remove the dissolved oxygen, less of the external carbon source and electron donor may be employed as compared to denitrification systems not assisted by nitrogen gas sparging.
FILED Thursday, March 04, 2021
APPL NO 17/192622
CURRENT CPC
Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/20 (20130101)
C02F 9/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210276960 Schiltz et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Northwestern University (Evanston, Illinois);  United States Goverment as represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Gary E. Schiltz (Naperville, Illinois);  Daniela E. Matei (Chicago, Illinois);  Purav Vagadia (Aurora, Illinois)
ABSTRACT Disclosed are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. The disclosed compounds inhibit the activity of tissue transglutaminase 2 (TG2). As such, the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with TG2 activity which may be cell proliferative diseases and disorders such as cancer.
FILED Wednesday, March 03, 2021
APPL NO 17/249519
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 239/42 (20130101)
C07D 239/48 (20130101) Original (OR) Class
C07D 401/12 (20130101)
C07D 403/12 (20130101)
C07D 409/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210279864 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio);  Louis Stokes Cleveland Veterans Administration Medical Center (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Neeraj Kumar (Cleveland Heights, Ohio);  Joseph E. Willis (Shaker Heights, Ohio)
ABSTRACT Embodiments discussed herein facilitate determination of cancer stages based at least in part on shape, size, and/or texture features of cancer nuclei. One example embodiment is a method, comprising: accessing at least a portion of a digital whole slide image (WSI) comprising a tumor; segmenting (e.g., via a first deep learning model) the tumor on the at least the portion of the digital WSI; segmenting (e.g., via a second deep learning model) cancer nuclei in the segmented tumor; extracting one or more features from the segmented cancer nuclei; providing the one or more features extracted from the segmented cancer nuclei to a trained machine learning model; and receiving, from the machine learning model, an indication of a cancer stage of the tumor.
FILED Monday, January 04, 2021
APPL NO 17/140586
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 7/0012 (20130101) Original (OR) Class
G06T 7/41 (20170101)
G06T 7/62 (20170101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30024 (20130101)
G06T 2207/30028 (20130101)
G06T 2207/30081 (20130101)
G06T 2207/30096 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/40 (20180101)
G16H 30/40 (20180101)
G16H 50/20 (20180101)
G16H 70/60 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 20210276709 NORTH et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) UNITED STATES OF AMERICA AS REPRESNTED BY THE ADMINSTRATOR OF NASA (WASHINGTON, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) DAVID D. NORTH (WILLIAMSBURG, Virginia);  MICHAEL P. HENDRICKSON (HAMPTON, Virginia);  JOSHUA . GLAAB (HAMPTON, Virginia)
ABSTRACT The presently disclosed embodiments relate to vertical takeoff and landing (VTOL) aircraft that have the capability of hovering in both a “nose forward” and a “nose up” orientation, and any orientation between those two. The disclosed aircraft can also transition into wing born (non-hovering) flight from any of the hovering orientations. In addition, certain of the disclosed embodiments can, if desired, use only vectored thrust control to maintain stable flight in both hover and forward flight. No control surfaces (e.g. ailerons, elevators, rudders, flaps) are required to maintain a stable vehicle attitude. However, the disclosure contemplates aircraft both with and without such control surfaces.
FILED Tuesday, May 25, 2021
APPL NO 17/329853
CURRENT CPC
Aeroplanes; Helicopters
B64C 11/46 (20130101)
B64C 11/48 (20130101)
B64C 29/0033 (20130101) Original (OR) Class
B64C 29/0075 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210278330 Gharib et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Jet Propulsion Laboratory (JPL)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S) California Institute of Technology (Pasadena, California)
INVENTOR(S) Morteza Gharib (Altadena, California);  Emile K. Oshima (Pasadena, California);  Pablo Hermoso Moreno (London, United Kingdom)
ABSTRACT A system and method for estimating the shear wall stress of an aerodynamic surface using a tuft visualization technique combined with a physics-informed neural network. The tuft visualization technique is a simplified method of generating velocity profile data of an aerodynamic model that can subsequently be used to generate a shear wall stress profile of the model. Systems and methods described herein also provide for additional input data using an augmented tuft and taps inputs for the physics-informed neural network to generate the shear wall stress profile.
FILED Monday, March 08, 2021
APPL NO 17/195228
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 3/12 (20130101) Original (OR) Class
G01N 3/068 (20130101)
G01N 2203/0246 (20130101)
G01N 2203/0641 (20130101)

Electric Digital Data Processing
G06F 30/15 (20200101)
G06F 30/27 (20200101)
G06F 30/28 (20200101)
G06F 2119/14 (20200101)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210282030 Barsoum et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Constellation Designs, LLC (Anaheim, California)
ASSIGNEE(S) Constellation Designs, LLC (Anaheim, California)
INVENTOR(S) Maged F. Barsoum (San Jose, California);  Christopher R. Jones (Pacific Palisades, California)
ABSTRACT Communication systems are described that use unequally spaced constellations that have increased capacity compared to conventional constellations operating within a similar SNR band. One embodiment is a digital communications system including a transmitter transmitting signals via a communication channel, the transmitter including a coder capable of receiving user bits and outputting encoded bits at a rate, a mapper capable of mapping encoded bits to symbols in a constellation, and a modulator capable of generating a modulated signal for transmission via the communication channel using symbols generated by the mapper, wherein the constellation is unequally spaced and characterizable by assignment of locations and labels of constellation points to maximize parallel decode capacity of the constellation at a given signal-to-noise ratio so that the constellation provides a given capacity at a reduced signal-to-noise ratio compared to a uniform constellation that maximizes the minimum distance between constellation points of the uniform constellation.
FILED Wednesday, May 19, 2021
APPL NO 17/325169
CURRENT CPC
Coding; Decoding; Code Conversion in General
H03M 13/255 (20130101)
H03M 13/6325 (20130101)

Transmission
H04B 15/00 (20130101)
H04B 17/336 (20150115)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 1/0003 (20130101)
H04L 1/0009 (20130101)
H04L 27/3405 (20130101)
H04L 27/3483 (20130101)
H04L 27/3809 (20130101)

Wireless Communication Networks
H04W 24/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210282031 Barsoum et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Constellation Designs, LLC (Anaheim, California)
ASSIGNEE(S) Constellation Designs, LLC (Anaheim, California)
INVENTOR(S) Maged F. Barsoum (San Jose, California);  Christopher R. Jones (Pacific Palisades, California)
ABSTRACT Communication systems are described that use unequally spaced constellations that have increased capacity compared to conventional constellations operating within a similar SNR band. One embodiment is a digital communications system including a transmitter transmitting signals via a communication channel, the transmitter including a coder capable of receiving user bits and outputting encoded bits at a rate, a mapper capable of mapping encoded bits to symbols in a constellation, and a modulator capable of generating a modulated signal for transmission via the communication channel using symbols generated by the mapper, wherein the constellation is unequally spaced and characterizable by assignment of locations and labels of constellation points to maximize parallel decode capacity of the constellation at a given signal-to-noise ratio so that the constellation provides a given capacity at a reduced signal-to-noise ratio compared to a uniform constellation that maximizes the minimum distance between constellation points of the uniform constellation.
FILED Wednesday, May 19, 2021
APPL NO 17/325171
CURRENT CPC
Coding; Decoding; Code Conversion in General
H03M 13/255 (20130101)
H03M 13/6325 (20130101)

Transmission
H04B 15/00 (20130101)
H04B 17/336 (20150115)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 1/0003 (20130101)
H04L 1/0009 (20130101)
H04L 27/3405 (20130101)
H04L 27/3483 (20130101)
H04L 27/3809 (20130101)

Wireless Communication Networks
H04W 24/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 20210277007 Jefson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Alkermes, Inc. (Waltham, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Martin R. Jefson (Stonington, Connecticut);  John A. Lowe, III (Stonington, Connecticut);  Fabian Dey (Basel, Switzerland);  Andreas Bergmann (Gauting, Germany);  Andreas Schoop (Grafrath, Germany);  Nathan Oliver Fuller (Arlington, Massachusetts)
ABSTRACT This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.
FILED Monday, December 28, 2020
APPL NO 17/134875
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/13 (20130101)
A61K 31/27 (20130101)
A61K 31/40 (20130101)
A61K 31/44 (20130101)
A61K 31/50 (20130101)
A6