FedInvent™ Patent Applications
Application Details for Thursday, September 16, 2021
This page was updated on Friday, September 17, 2021 at 04:45 PM GMT
Department of Health and Human Services (HHS)
| US 20210282642 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongping Chen (Irvine, California); Jason Chen (Irvine, California); Yan Li (Irvine, California) |
| ABSTRACT | The present invention is directed to a system for multimodal imaging through the use of a dual-rotational imaging catheter. The system may comprise a swept-source laser for providing a light source for OCT and OCE imaging, and an optical fiber coupler that splits said light source into one for a compensation arm and the other for the imaging catheter. The imaging catheter may comprise a rotary apparatus for a first scanning method, and a distal motor for a second scanning method. The dual-rotational model may allow for optimal performance of multiple imaging modalities. The imaging catheter may utilize optical imaging and acoustic imaging. A balanced photodetector receives input from the destinations of both light sources to offset DC noise. An US pulser/receiver is used for US imaging, a multifunction I/O module, a function generator, and an amplifier are used for generating an acoustic excitation force for OCE imaging. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197897 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0035 (20130101) Original (OR) Class A61B 5/0066 (20130101) A61B 5/0075 (20130101) A61B 5/6852 (20130101) A61B 5/7225 (20130101) A61B 5/7257 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210282655 | Rege et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vasoptic Medical, Inc. (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhishek Rege (Baltimore, Maryland); M. Jason Brooke (University Park, Maryland); Kartikeya Murari (Calgary, Canada); Yusi Liu (Rockville, Maryland) |
| ABSTRACT | Examination of the structure and function of blood vessels is an important means of monitoring the health of a subject. Such examination can be important for disease diagnoses, monitoring specific physiologies over the short- or long-term, and scientific research. This disclosure describes technology and various embodiments of a system and method for imaging blood vessels and the intra-vessel blood flow, using at least laser speckle contrast imaging, with high speed so as to provide a rapid estimate of vessel-related or blood flow-related parameters. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333568 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/14 (20130101) A61B 3/1233 (20130101) A61B 5/02 (20130101) A61B 5/0066 (20130101) A61B 5/0261 (20130101) Original (OR) Class A61B 5/721 (20130101) A61B 5/742 (20130101) A61B 5/7207 (20130101) Optical Elements, Systems, or Apparatus G02B 27/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210282680 | Rehan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Los Angeles BioMedical Research Institute at Harbor UCLA Medical Center (Torrance, California); Intelligent Optical Systems (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Virender Rehan (Torrance, California); Jesus Delgado (Torrance, California) |
| ABSTRACT | Embodiments described herein relate to a catheter configured to detect at least one blood gas parameter present in blood in an artery of a patient, including, but not limited to, a catheter wall forming at least one lumen configured for umbilical arterial catheterization, at least one optical fiber incorporated in the catheter wall, wherein the at least one optical fiber is configured to detected the at least one blood gas parameter. |
| FILED | Thursday, July 27, 2017 |
| APPL NO | 16/321798 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/1459 (20130101) A61B 5/6852 (20130101) A61B 5/14552 (20130101) A61B 5/14557 (20130101) Original (OR) Class A61B 5/150038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210282699 | Franz et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Roy Franz (Durham, North Carolina); Mu Qiao (Ruston, Louisiana) |
| ABSTRACT | Methods, systems, and computer readable media for utilizing visuomotor error augmentation for balance rehabilitation are provided. An exemplary method includes displaying a dynamic virtual environment defined by an optical flow, obtaining position data of an anatomical portion of a subject that is virtually traversing the dynamic virtual environment, and using the position data to determine a mediolateral displacement measurement of the subject. The method further includes utilizing the mediolateral displacement measurement to define feedback control loop data, establishing an augmented visual error that dynamically adjusts the dynamic virtual environment, wherein the augmented visual error is based on the feedback control loop data and a predefined visual gain factor, and adjusting the optical flow of the dynamic virtual environment by using the augmented visual error. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/202989 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/112 (20130101) A61B 5/4023 (20130101) Original (OR) Class A61B 2505/09 (20130101) Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 26/003 (20130101) A63B 71/0622 (20130101) A63B 2071/0644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210282851 | van der Weide et al. |
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| FUNDED BY |
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| APPLICANT(S) | NeuWave Medical, Inc. (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Warren van der Weide (Madison, Wisconsin); Paul F. Laeseke (Menlo Park, California); Fred T. Lee, JR. (Madison, Wisconsin); Christopher Lee Brace (Middleton, Wisconsin) |
| ABSTRACT | The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/328477 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/1815 (20130101) Original (OR) Class A61B 2017/00084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210282857 | BELL et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Muyinatu BELL (Baltimore, Maryland); Joshua SHUBERT (Santa Monica, California) |
| ABSTRACT | A may comprise a first optical fiber and an optical interface connected to the first optical fiber. The optical interface may be configured to transfer laser light from the first optical fiber to a second optical fiber in a drill bit. The second optical fiber may propagate the laser light to a face of the drill bit to create an ultrasonic emission. |
| FILED | Monday, July 15, 2019 |
| APPL NO | 17/260943 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1615 (20130101) A61B 17/1626 (20130101) A61B 18/26 (20130101) Original (OR) Class A61B 2018/00339 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210282886 | KRUECKER et al. |
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| FUNDED BY |
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| APPLICANT(S) | KONINKLIJKE PHILIPS N.V. (EINDHOVEN, Netherlands); THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JOCHEN KRUECKER (ANDOVER, Massachusetts); PINGKUN YAN (GAITHERSBURG, Maryland); AMIR MOHAMMAD TAHMASEBI MARAGHOOSH (ARLINGTON, Massachusetts); PETER A PINTO (BETHESDA, Maryland); BRADFORD JOHNS WOOD (POTOMAC, Maryland) |
| ABSTRACT | A system for planning and performing a repeat interventional procedure is provided which includes a registration device and an image generation device which map current targets in a reference image for a first interventional procedure to at least one guidance image acquired from a different imaging modality. Biopsy locations are recorded to the guidance images during the first interventional procedure and the biopsy locations are mapped to the reference image to provide a planning image for use in a subsequent interventional procedure on the patient. In a subsequent interventional procedure, the prior planning image (124) may be registered to a current reference image and the prior biopsy locations and prior and current targets are mapped to a guidance image acquired from a different imaging modality. Biopsy locations are then mapped to the guidance image and mapped back to the current reference image. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/329216 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/085 (20130101) A61B 8/463 (20130101) A61B 8/0841 (20130101) A61B 8/5261 (20130101) A61B 10/0241 (20130101) A61B 34/10 (20160201) A61B 90/36 (20160201) Original (OR) Class A61B 2034/107 (20160201) A61B 2090/374 (20160201) Image Data Processing or Generation, in General G06T 7/0014 (20130101) G06T 11/003 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 20/40 (20180101) G16H 30/20 (20180101) G16H 30/40 (20180101) G16H 40/63 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 70/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210282961 | Maier et al. |
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| FUNDED BY |
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| APPLICANT(S) | Reia, LLC (Lyme, New Hampshire) |
| ASSIGNEE(S) | Reia, LLC (Lyme, New Hampshire) |
| INVENTOR(S) | Kaitlin E. Maier (Darien, Connecticut); Meegan P. Daigler (Portland, Maine); Ariana M. Sopher (Somerville, Massachusetts) |
| ABSTRACT | A pessary providing various structures, parts, and components to enable the pessary to remain deployed in a supportive position so that it may reliably provide the desired supportive capabilities. A ridge structure prevents over-rotation of the supportive members. The pessary can be formed preferably by injection molding where the mold has at least one insert. The geometry of the pessary can enable the pessary to have the required stiffness, flexibility, hinged capability, and softness where needed to achieve a pessary that is superior to prior art pessaries. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331312 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 6/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283054 | BLUM et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Angela P. BLUM (San Diego, California); Jacquelin K. KAMMEYER (San Diego, California); Nathan C. GIANNESCHI (San Diego, California) |
| ABSTRACT | Described herein, inter alia, are peptide containing polymers, and methods of making and using the same. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/160588 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/146 (20130101) A61K 9/1075 (20130101) Original (OR) Class A61K 47/42 (20130101) A61K 47/58 (20170801) Peptides C07K 14/001 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) C08G 2261/80 (20130101) C08G 2261/90 (20130101) C08G 2261/94 (20130101) C08G 2261/126 (20130101) C08G 2261/148 (20130101) C08G 2261/164 (20130101) C08G 2261/334 (20130101) C08G 2261/418 (20130101) C08G 2261/1424 (20130101) C08G 2261/1432 (20130101) C08G 2261/1644 (20130101) C08G 2261/1646 (20130101) C08G 2261/3324 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283068 | Green et al. |
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| FUNDED BY |
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| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| INVENTOR(S) | Douglas R. Green (Memphis, Tennessee); Larissa Dias da Cunha (Memphis, Tennessee) |
| ABSTRACT | Compositions and methods are provided for suppressing tumors by modulating the LAP pathway. Targeting components of the LAP pathway for specific drug design can be used as n immunotherapy strategy that modulates the tumor microenvironment. It is well established that infiltrating monocytes and macrophages play a pivotal role in shaping an immunosuppressive tumor microenvironment. By modulating LAP in the innate immune cells, the function of effector T cells can be manipulated toward an effective, cytotoxic immune response that can eliminate tumor cells. Thus, methods are provided for reducing the size or number of tumor cells and for treating cancer or other cell proliferative disorders. Further provided are methods for increasing the Th1 response or increasing IFNγ and/or TNFα expression in the tumor microenvironment by administering a LAP inhibitor. |
| FILED | Wednesday, April 18, 2018 |
| APPL NO | 16/606002 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/03 (20130101) Original (OR) Class A61K 31/12 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283107 | Melander et al. |
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| FUNDED BY |
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| APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Melander (Raleigh, North Carolina); Roberta Melander (Raleigh, North Carolina) |
| ABSTRACT | Provided herein is a method to treat a Gram-negative bacterial infection in a subject in need thereof, comprising administering a compound of Formula I: in combination with a Gram-positive antibiotic to said subject in a treatment-effective amount. Also provided is a method to control Gram-negative bacteria, comprising applying a compound of Formula I in combination with a Gram-positive antibiotic in a Gram-negative bactericidal-effective amount. |
| FILED | Monday, August 14, 2017 |
| APPL NO | 16/325602 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4168 (20130101) Original (OR) Class A61K 31/5377 (20130101) A61K 31/7048 (20130101) A61K 31/7052 (20130101) A61K 38/12 (20130101) A61K 38/14 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283113 | Markowitz et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford Markowitz (Pepper Pike, Ohio); Stanton Gerson (Hunting Valley, Ohio); Amar Desai (Cleveland, Ohio); Won Jin Ho (Cleveland, Ohio) |
| ABSTRACT | A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor. |
| FILED | Wednesday, December 23, 2020 |
| APPL NO | 17/131911 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) A61K 31/4365 (20130101) Original (OR) Class Heterocyclic Compounds C07D 277/00 (20130101) C07D 277/02 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283115 | Abergel et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca J. Abergel (Kensington, California); Taylor A. Choi (South San Francisco, California); Kenneth N. Raymond (Berkeley, California); David K. Shuh (Oakland, California) |
| ABSTRACT | Provided herein are pharmaceutical formulations comprising a 1,2-HOPO chelating agent and/or 3,2-HOPO chelating agent. |
| FILED | Tuesday, September 05, 2017 |
| APPL NO | 16/330601 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0056 (20130101) A61K 9/0095 (20130101) A61K 9/1611 (20130101) A61K 9/1623 (20130101) A61K 9/1652 (20130101) A61K 9/2009 (20130101) A61K 9/2018 (20130101) A61K 9/2054 (20130101) A61K 31/444 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283124 | Linstedt et al. |
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| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam D. Linstedt (Pittsburgh, Pennsylvania); Lina Song (Gainesville, Florida); Collin Bachert (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are small molecule-inhibitors of site-specific O-glycosylation and the identification of such using cell-based fluorescent biosensors. Also provided herein are methods of treating kidney disease and cancer, such as breast cancer. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/330779 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) A61P 35/04 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) G01N 33/5008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283138 | Lee et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taekyu Lee (Brentwood, Tennessee); James C. Tarr (Franklin, Tennessee); KyuOk Jeon (Nashville, Tennessee); James M. Salovich (Nashville, Tennessee); Subrata Shaw (Nashville, Tennessee); Nagarathanam Veerasamy (Nashville, Tennessee); Kwangho Kim (Nashville, Tennessee); Plamen P. Christov (Mount Juliet, Tennessee); Edward T. Olejniczak (Nashville, Tennessee); Bin Zhao (Brentwood, Tennessee); Stephen W. Fesik (Nashville, Tennessee); Zhiguo Bian (Lake Bluff, Illinois) |
| ABSTRACT | The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein. |
| FILED | Friday, March 03, 2017 |
| APPL NO | 16/081709 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/538 (20130101) A61K 31/551 (20130101) Original (OR) Class A61K 31/4985 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 403/14 (20130101) C07D 487/04 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283144 | Bulun et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Serdar E. Bulun (Chicago, Illinois); Hong Zhao (Wilmette, Illinois) |
| ABSTRACT | Disclosed are methods and compositions for treating and/or preventing hernias in subjects in need thereof. The disclosed methods of treatment and/or preventing may include methods for treating and/or preventing hernias in subject in need thereof by administering to the subject a therapeutic agent that modulates sex steroid hormone production and/or activity in the subject. Hernias treated and/or prevented by the disclosed methods may include, but are not limited to, inguinal hernias, femoral hernias, umbilical hernias, hiatal hernias, incisional hernias, and diastasis recti. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198558 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/0063 (20130101) A61F 2250/0067 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/56 (20130101) A61K 31/566 (20130101) A61K 31/4196 (20130101) A61K 31/4535 (20130101) A61K 31/5685 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283148 | SINHA et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Sidhartha Ranjit SINHA (Stanford, California); Jayakumar RAJADAS (Stanford, California); Aida HABTEZION (Stanford, California); Ravinder D. PAMNANI (Stanford, California) |
| ABSTRACT | Enema compositions containing corticosteroids or salicylic acid derivatives are disclosed. The compositions are liquid at room temperature but turn to gels at body temperature. They are useful for treating inflammatory bowel disease. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332431 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0031 (20130101) A61K 9/107 (20130101) A61K 9/1272 (20130101) A61K 31/58 (20130101) Original (OR) Class A61K 31/60 (20130101) A61K 31/573 (20130101) A61K 31/606 (20130101) A61K 31/655 (20130101) A61K 47/24 (20130101) A61K 47/30 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Compositions of Macromolecular Compounds C08L 71/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283155 | Morrow et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio); The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts); Instituto Nacional de Ciencias Medicas Y Nutricion (Ciudad de Mexico, Mexico) |
| ASSIGNEE(S) | Children's Hospital Medical Center (Cincinnatti, Ohio); The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts); Instituto Nacional de Ciencias Medicas Y Nutricion (Ciudad de Mexico, Mexico) |
| INVENTOR(S) | Ardythe L. Morrow (Cincinnatti, Ohio); David S. Newburg (Newtonville, Massachusetts); Guillermo M. Ruiz-Palacios (Mexico City, Mexico) |
| ABSTRACT | A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333614 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/40 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 31/702 (20130101) A61K 31/7016 (20130101) Original (OR) Class A61K 35/20 (20130101) A61K 47/62 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283159 | JIANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | ASCLEA CORPORATION (Las Vegas, Nevada); THE UNITED STATES OF AMERICA, as represented by the Secretary, Dept,of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | ASCLEA CORPORATION (Las Vegas, Nevada); THE UNITED STATES OF AMERICA, as represented by the Secretary, Dept, of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Enhong JIANG (Shenyang, China PRC); Zhengping ZHUANG (Bethesda, Maryland); Jing CUI (Potomac, Maryland) |
| ABSTRACT | A pharmaceutical composition containing any one or more of 4″-O-isolvalerylspiramycin I, II and III counters tumorigenesis and reduces or prevents metastasis by inhibiting selenoprotein H to trigger genomic instability and cell-cycle arrest in cancer cells. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 16/816068 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283163 | Ji |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ru-Rong Ji (Durham, North Carolina) |
| ABSTRACT | Disclosed herein are miR-711 inhibitors. The miR-711 inhibitors may disrupt the binding of miR-711 to TRPA1. Further provided are methods of treating a disease or condition in a subject, methods of inhibiting miR-711, and methods of inhibiting TRPA1 in a subject. The methods may include administering to the subject a miR-711 inhibitor. |
| FILED | Thursday, July 18, 2019 |
| APPL NO | 17/260439 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/15 (20130101) A61K 31/7088 (20130101) Original (OR) Class A61K 38/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/113 (20130101) C12N 2310/141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283178 | CHEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianzhu CHEN (Lexington, Massachusetts); Guozhu XIE (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to compounds (e.g., antibodies, antigen-binding fragments thereof, bispecific molecules, or chimeric antigen receptor polypeptides) that bind to a neoepitope of mutant nucleophosmin (NPM1c) in complex with, or presented by, a class I major histocompatibility complex (MHC class I) protein, or cells expressing such compounds, and their use in methods for treating, or ameliorating one or more symptoms of, cancer. |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/144834 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/3061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283184 | Mitchell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Duane Mitchell (Gainesville, Florida); Catherine Flores (Gainesville, Florida) |
| ABSTRACT | The combination of adoptive cell therapy with CCR2 positive (CCR2+) hematopoietic stem cell transplantation increases T cell activation and survival. |
| FILED | Thursday, December 21, 2017 |
| APPL NO | 16/472618 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283185 | Kirkland et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James L. Kirkland (Rochester, Minnesota); Tamar Tchkonia (Rochester, Minnesota); Stefan Tullius (Boston, Massachusetts); Ming Xu (Avon, Connecticut); Joao Passos (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials for treating aging and/or improving transplant outcomes. For example, methods and materials for using one or more senotherapeutic agents to reduce risk of transplant rejection are provided. Non-human animal models for transplant rejection as well as methods for using such non-human animal models to identify agents having the ability to reduce transplant rejection are provided as are non-human animal models for aging and methods for using such non-human animal models to identify agents having the ability to treat aging or the ability to slow the effects of aging. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/257923 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) A01K 2207/12 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/353 (20130101) A61K 31/506 (20130101) A61K 35/28 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210283187 — COMPOSITIONS AND METHODS FOR TREATING TYPE 1 AND TYPE 2 DIABETES AND RELATED DISORDERS
| US 20210283187 | EVANS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SALK INSTITUTE FOR BIOLOGICAL STUDIES (LA JOLLA, California) |
| ASSIGNEE(S) | SALK INSTITUTE FOR BIOLOGICAL STUDIES (LA JOLLA, California) |
| INVENTOR(S) | RONALD M. EVANS (LA JOLLA, California); EIJI YOSHIHARA (LA JOLLA, California); MICHAEL R. DOWNES (LA JOLLA, California); RUTH T. YU (LA JOLLA, California); ANNETTE R. ATKINS (LA JOLLA, California) |
| ABSTRACT | The invention features compositions comprising in vitro generated beta cells capable of glucose-stimulated insulin secretion, methods of inducing beta cell maturation from embryonic or induced pluripotent stem cell-derived beta-like cells, and methods of using in vitro generated beta cells for the treatment of type 1 diabetes, type 2 diabetes, or a related disorder. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/141327 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/35 (20130101) A61K 35/39 (20130101) Original (OR) Class A61K 35/51 (20130101) A61K 35/545 (20130101) A61K 38/00 (20130101) A61K 48/00 (20130101) Peptides C07K 14/721 (20130101) C07K 14/70567 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0676 (20130101) C12N 15/85 (20130101) C12N 15/86 (20130101) C12N 2501/392 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283215 | Gallo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard L. Gallo (San Diego, California); Teruaki Nakatsuji (San Diego, California); Alan O'Neill (San Diego, California) |
| ABSTRACT | The disclosure relates to composition and methods to treat dermatological diseases and disorders and to composition useful for treating acne. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/275851 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0014 (20130101) A61K 35/741 (20130101) A61K 38/164 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/10 (20180101) A61P 31/02 (20180101) A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283219 | Connor |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kip M. Connor (Lexington, Massachusetts) |
| ABSTRACT | Described herein are methods and compositions for reducing or inhibiting retinal cell death in a subject comprising retinal ischemic injury. The method comprises administering to an ischemic retinal tissue of the subject a composition comprising an agent that inhibits or reduces alternative complement pathway activity to reduce or inhibit complement-mediated retinal, neuronal, or retinal neuronal cell death during disease or injury. |
| FILED | Friday, August 10, 2018 |
| APPL NO | 16/637992 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1725 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283232 | McNeel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Madison Vaccines Inc. (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Doug McNeel (Madison, Wisconsin); Richard Lesniewski (Madison, Wisconsin) |
| ABSTRACT | Provided herein is technology relating to cancer treatment and prevention and particularly, but not exclusively, to compositions and methods related to therapies for prostate cancer. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313335 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/001163 (20180801) A61K 39/001193 (20180801) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/53 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/3069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283233 | Kurtis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rhode Island Hospital (Providence, Rhode Island); Seattle Children's Hospital dba Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Kurtis (Providence, Rhode Island); Christian Parcher Nixon (Little Compton, Rhode Island); Dipak Kumar Raj (Pawtucket, Rhode Island); Jennifer Frances Friedman (Providence, Rhode Island); Michal Fried (Rockville, Maryland); Patrick Emmet Duffy (Washington, District of Columbia) |
| ABSTRACT | The invention provides compositions and methods for preventing or reducing the severity of malaria. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/178111 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 39/39575 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/445 (20130101) C07K 16/44 (20130101) C07K 16/205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283240 | Kwong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Institute for Research in Biomedicine (Bellinzona, Switzerland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); Institute for Research in Biomedicine (Bellinzona, Switzerland) |
| INVENTOR(S) | Peter Kwong (Washington, District of Columbia); Michael Gordon Joyce (Washington, District of Columbia); Baoshan Zhang (Bethesda, Maryland); Yongping Yang (Potomac, Maryland); Peter Collins (Kensington, Maryland); Ursula Buchholz (Silver Spring, Maryland); Davide Corti (Bellinzona, Switzerland); Antonio Lanzavecchia (Bellinzona, Switzerland); Guillaume Stewart-Jones (Cambridge, Massachusetts) |
| ABSTRACT | Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/334505 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/155 (20130101) Original (OR) Class A61K 48/00 (20130101) Peptides C07K 14/005 (20130101) C07K 14/135 (20130101) C07K 2319/70 (20130101) C07K 2319/73 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/18322 (20130101) C12N 2760/18334 (20130101) C12N 2760/18522 (20130101) C12N 2760/18534 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283248 | LIVINGSTON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ADJUVANCE TECHNOLOGIES, INC. (Lincoln, Nebraska); MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | Adjuvance Technologies, Inc. (Lincoln, Nebraska); Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Philip LIVINGSTON (New York, New York); Govind RAGUPATHI (New York, New York); Jeffrey GARDNER (New York, New York); J Tyler MARTIN (Roca, Nebraska) |
| ABSTRACT | The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases. |
| FILED | Wednesday, April 25, 2018 |
| APPL NO | 16/608296 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/55561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283258 | Davis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute Of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark E. Davis (Pasadena, California); Han Han (Belmont, California) |
| ABSTRACT | Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a nitroboronic boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing the nitroboronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/325292 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5161 (20130101) A61K 31/337 (20130101) A61K 31/727 (20130101) A61K 31/4745 (20130101) A61K 45/06 (20130101) Original (OR) Class A61K 47/60 (20170801) A61K 47/6935 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210283270 — COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF THERAPEUTIC AND/OR DIAGNOSTIC AGENTS
| US 20210283270 | YANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian YANG (State College, Pennsylvania); Cheng DONG (State College, Pennsylvania); Zhiwei XIE (State College, Pennsylvania) |
| ABSTRACT | In one aspect, methods of targeted nanoparticle and cell delivery are described herein. In some embodiments, methods described herein comprise coupling nanoparticles and cells to a carrier cell to form a nanoparticle-cell conjugate or cell-cell conjugate, disposing the nanoparticle-cell or cell-cell conjugate in a biological environment, and delivering the nanoparticles and cells to target cells or tissues located within the biological environment. The nanoparticles comprise a biodegradable photoluminescent polymer, and the nanoparticle-cell conjugate is formed using one or more click chemistry reaction products. |
| FILED | Monday, January 06, 2020 |
| APPL NO | 16/734816 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) A61K 31/337 (20130101) A61K 31/437 (20130101) A61K 47/62 (20170801) A61K 47/65 (20170801) A61K 47/593 (20170801) A61K 47/6901 (20170801) Original (OR) Class A61K 47/6937 (20170801) A61K 49/0093 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283274 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Trustees of the University of Pennsylvania (Phladelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David V. Schaffer (Danville, California); John G. Flannery (Berkeley, California); William A. Beltran (Philadelphia, Pennsylvania); Leah C. Byrne (San Francisco, California); Meike Visel (El Cerrito, California) |
| ABSTRACT | The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease. |
| FILED | Thursday, July 27, 2017 |
| APPL NO | 16/315032 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 48/0075 (20130101) A61K 48/0091 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283281 | LEWIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York); RHODE ISLAND COUNCIL ON POSTSECONDARY EDUCATION (Warwick, Rhode Island); PHLIP, INC. (Kingston, Rhode Island) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York); RHODE ISLAND COUNCIL ON POSTSECONDARY EDUCATION (Warwick, Rhode Island); PHLIP, INC. (Kingston, Rhode Island) |
| INVENTOR(S) | Jason S. LEWIS (New York, New York); Dustin DEMOIN (New York, New York); Yana K. RESHETNYAK (Saunderson, Rhode Island); Oleg A. ANDREEV (Saunderson, Rhode Island); Donald M. ENGELMAN (New Haven, Connecticut); Narissa VIOLA-VILLEGAS (New York, New York) |
| ABSTRACT | The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject. |
| FILED | Saturday, July 29, 2017 |
| APPL NO | 16/321429 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) A61K 47/545 (20170801) A61K 47/547 (20170801) A61K 51/088 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283311 | Bertassoni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luiz Bertassoni (Portland, Oregon); Anthony Tahayeri (Sherwood, Oregon); Avathamsa Athirasala (Hillsboro, Oregon); Jack L. Ferracane (Portland, Oregon) |
| ABSTRACT | Disclosed is a method for filling a root canal in a tooth. The method includes positioning a fiber in the root canal of the tooth, filling at least a portion of the root canal with an unset hydrogel composition, such that the unset hydrogel composition contacts at least a portion of the fiber, setting the hydrogel composition, thereby forming a set hydrogel, and removing the fiber from the set hydrogel, thereby leaving a channel in the set hydrogel. Methods and kits for repairing teeth are also described. |
| FILED | Wednesday, May 30, 2018 |
| APPL NO | 16/618329 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/12 (20130101) A61L 27/52 (20130101) Original (OR) Class A61L 27/222 (20130101) A61L 2400/06 (20130101) A61L 2430/12 (20130101) Compositions of Macromolecular Compounds C08L 89/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283324 | Madhani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh- Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Carnegie Mellon University (Pittsburgh, Pennsylvania); Mississippi State University (Mississippi State, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shalv Madhani (Miplitas, California); Brian Joseph Frankowski (Imperial, Pennsylvania); William J. Federspiel (Pittsburgh, Pennsylvania); Gregory Burgreen (Starkville, Mississippi); James F. Antaki (Ithaca, New York) |
| ABSTRACT | An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. The plurality of hollow gas permeable fibers extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet. The system further includes a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers and a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/328049 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/1625 (20140204) A61M 1/1698 (20130101) A61M 1/3666 (20130101) A61M 1/3667 (20140204) Original (OR) Class A61M 60/82 (20210101) A61M 60/113 (20210101) A61M 60/205 (20210101) A61M 60/419 (20210101) A61M 60/818 (20210101) A61M 60/824 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283332 | Damiano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts); Beta Bionics, Inc. (Concord, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward R. Damiano (Acton, Massachusetts); Firas H. El-Khatib (Allston, Massachusetts); David Lim (Irvine, California); Mike Rosinko (Anaheim, California) |
| ABSTRACT | A controller in a system for automatic control of blood glucose level of a subject is operative to generate an insulin dose control signal for controlling insulin delivery by a delivery device, based on time-varying glucose levels of the subject as represented by an actual glucose level signal over time. The controller operates at a regular frequency to generate the insulin dose control signal to regulate the glucose levels in the subject and employs a control algorithm that functions in conjunction with and accounting for user-determined doses, such as meal doses, whose values are entered into the controller and delivered on command of a user. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197420 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 5/14248 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2230/201 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283401 | Tai |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changfeng Tai (Wexford, Pennsylvania) |
| ABSTRACT | Provided herein is a method of blocking a nerve or neuron by applying an electrical stimulation to the nerve or neuron, wherein the electrical stimulation is of an intensity below the excitation threshold of the nerve or neuron for a length of time sufficient to produce a block of nerve conduction or neuron excitation. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/330883 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0551 (20130101) A61N 1/36062 (20170801) A61N 1/36071 (20130101) A61N 1/36153 (20130101) A61N 1/36157 (20130101) A61N 1/36164 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283567 | Ciccia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University In The City Of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alberto Ciccia (New York, New York); Pierre Billon (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, specially designed DNA adaptors and methods of preparing the same. Methods and kits for carrying out and detecting marker-free precision genome editing and genetic variation using such adaptors are also provided. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/192836 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Original (OR) Class B01J 2219/00315 (20130101) B01J 2219/00369 (20130101) B01J 2219/00378 (20130101) B01J 2219/00387 (20130101) B01J 2219/00504 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/06 (20130101) C40B 60/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283597 | Kluge et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VAXESS TECHNOLOGIES, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | VAXESS TECHNOLOGIES, INC. (Cambridge, Massachusetts) |
| INVENTOR(S) | Jonathan A. Kluge (Cambridge, Massachusetts); Alexander Beliveau (Cambridge, Massachusetts); Adrian Benton Li (Cambridge, Massachusetts); Matthew Dirckx (Cambridge, Massachusetts); Michael A. Schrader (Cambridge, Massachusetts); Kathryn M. Kosuda (Cambridge, Massachusetts); Elizabeth Whitney Johansen (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to the collection, storage, and stabilization of biological samples (e.g., bodily fluids, such as whole blood, blood serum, and blood plasma), and analytes thereof. More particularly, the present invention relates to polymer-based biological sample collection devices, and methods of making and using the same. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157451 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) Original (OR) Class B01L 2300/046 (20130101) B01L 2300/069 (20130101) B01L 2300/0838 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284622 | Pfeifer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carmem Pfeifer (Portland, Oregon); Matthew Logan (Portland, Oregon); Alexander Kendall (Portland, Oregon); Ana Paula Piovezan Fugolin (Portland, Oregon); Steven Lewis (Portland, Oregon) |
| ABSTRACT | The present invention provides polymers capable of inhibiting the growth of biofilms, including biofilms of Streptococcus mutans. The invention also provides monomers for use in the preparation of such polymers. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/191552 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 6/69 (20200101) A61K 6/887 (20200101) Heterocyclic Compounds C07D 239/20 (20130101) C07D 307/85 (20130101) C07D 333/70 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284624 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael Gray (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Eric Fischer (Chestnut Hill, Massachusetts); Alyssa Verano (Allston, Massachusetts); Zhixiang He (Brookline, Massachusetts); Guangyan Du (Jamaica Plain, Massachusetts); Katherine Donovan (Boston, Massachusetts); Radoslaw Nowak (Boston, Massachusetts); Jing Ting Christine Yuan (Brookline, Massachusetts); Hu Liu (Newton, Massachusetts) |
| ABSTRACT | Disclosed are immunomodulatory compounds, pharmaceutical compositions containing them, and methods of making and using the compounds to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon. |
| FILED | Thursday, June 27, 2019 |
| APPL NO | 17/255738 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284626 | BOGYO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Matthew S. BOGYO (Redwood City, California); Martijn VERDOES (Nijmegen, Netherlands) |
| ABSTRACT | Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal. |
| FILED | Monday, November 09, 2020 |
| APPL NO | 17/092587 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0034 (20130101) A61K 49/0041 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284643 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts); University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei Zhang (Boston, Massachusetts); Jian Zhu (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. Related pharmaceutical compositions are disclosed. Methods of treatment with the disclosed compounds and compositions are also disclosed. Related kits are further disclosed. |
| FILED | Friday, July 28, 2017 |
| APPL NO | 16/321589 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284649 | Arnold et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin); The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander E. Arnold (Milwaukee, Wisconsin); Douglas C. Stafford (Stoughton, Wisconsin); James M. Cook (Milwaukee, Wisconsin); Charles W. Emala (Woodcliff Lake, New Jersey); Gloria Forkuo (Milwaukee, Wisconsin); Rajwana Jahan (Milwaukee, Wisconsin); Revathi Kodali (Milwaukee, Wisconsin); Guanguan Li (Milwaukee, Wisconsin); Michael Rajesh Stephen (Milwaukee, Wisconsin) |
| ABSTRACT | Pyrrolobenzodiazepines target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects. |
| FILED | Wednesday, August 16, 2017 |
| APPL NO | 16/325080 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) C07D 487/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284663 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | XAVIER UNIVERSITY OF LOUSIANA (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guangdi WANG (New Orleans, Louisiana); Jiawang LIU (New Orleans, Louisiana); Shilong ZHENG (New Orleans, Louisiana); Shanchun GUO (Tucker, Georgia) |
| ABSTRACT | The present disclosure relates to androgen receptor signaling inhibitors and the synthesis of the same. Further, the present disclosure teaches the utilization of the androgen receptor signaling inhibitors in a treatment for proliferative diseases, including cancer, particularly prostate cancer, and especially castration-resistant prostate cancer. |
| FILED | Wednesday, November 22, 2017 |
| APPL NO | 16/463135 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 235/56 (20130101) C07C 255/60 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284664 | Johnson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jeremiah A. Johnson (Boston, Massachusetts); Peyton Shieh (Cambridge, Massachusetts); Wenxu Zhang (Belmont, Massachusetts) |
| ABSTRACT | The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204462 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/787 (20130101) A61K 45/06 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0834 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/06 (20130101) Compositions of Macromolecular Compounds C08L 79/08 (20130101) C08L 83/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284691 | Krusemark et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Casey J Krusemark (West Lafayette, Indiana); Emily C Dykhuizen (West Lafayette, Indiana); Sijie Wang (Lafayette, Indiana) |
| ABSTRACT | The present invention relates to series of peptidomimetic compounds selectively targeting CBX8 of polycomb chromobox protein homolog proteins. Pharmaceutical compositions of those compounds and methods of using them in the treatment of diseases involved CBX8 pharmacology, including various cancers and leukemia, by administering therapeutically effective amounts of such compound alone or together with other therapeutics, are within the scope of this disclosure. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/323683 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284699 | Gradinaru et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viviana Gradinaru (Pasadena, California); Xiaozhe Ding (Pasadena, California) |
| ABSTRACT | Disclosed herein include methods, compositions, and kits comprising variant AAV capsids. Variant capsid proteins, including guided variant capsid proteins, tandem multimers, and/or HI loop variant capsid proteins, are provided in some embodiments. The variant capsid proteins disclosed herein are capable of assembling into a variant AAV capsid with an expanded size (e.g., diameter) and/or genetic cargo capacity. Methods generating recombinant AAV (rAAV) with expanded capsids are provided. Methods of treating diseases and disorders using said rAAV are also disclosed. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/199293 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/015 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2750/14133 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284701 | Kukar |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Kukar (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to purified and recombinant granulins, fusions, or variants and vectors encoding the same. In certain embodiments, this disclosure relates to uses of these granulins or vectors, alone or in combination, in the treatment or prevention of diseases or conditions associated with lysosomal defects such as frontotemporal dementia and Alzheimer's disease. |
| FILED | Thursday, July 13, 2017 |
| APPL NO | 16/317731 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/475 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284706 | Krupnick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Sasha Krupnick (St. Louis, Missouri); Daved Henry Fremont (St. Louis, Missouri); Eric Reed Lazear (St. Louis, Missouri); John Westwick (Houston, Texas) |
| ABSTRACT | The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to an NKG2D ligand or PD1 ligand and may improve immunotherapy by limiting side effects associated with immunotherapy. The present disclosure also encompasses compositions and methods for recruiting cytotoxic lymphocytes to target cells using NKG2D receptor ligands or PD1 ligands. The compositions disclosed herein comprise a NKG2D receptor ligand and a targeting molecule and may improve immunotherapy by limiting side effects associated with immunotherapy. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238995 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/6849 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/52 (20130101) C07K 14/55 (20130101) Original (OR) Class C07K 14/545 (20130101) C07K 14/5418 (20130101) C07K 14/5443 (20130101) C07K 14/70596 (20130101) C07K 16/2851 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284708 | Gonias et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The J. David Gladstone Institutes (San Francisco, California) |
| INVENTOR(S) | Steven L. Gonias (San Diego, California); Travis Stiles (San Diego, California); Alban Gaultier (Charlottesville, Virginia); Wendy M. Campana (La Jolla, California); Katerina Akassoglou (San Francisco, California) |
| ABSTRACT | This invention provides methods for promoting and/or restoring neurite outgrowth and neuronal regeneration by contacting an injured neuron with an inhibitor of low density lipoprotein receptor-related protein-1 (LRP-1). |
| FILED | Thursday, November 05, 2020 |
| APPL NO | 17/090566 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/18 (20130101) A61K 38/177 (20130101) A61K 45/06 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class C07K 16/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/1138 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284723 | KEANE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Miami (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. KEANE (Miami, Florida); W. Dalton DIETRICH (Miami, Florida); Juan Pablo DE RIVERO VACCARI (Miami, Florida); Helen M. BRAMLETT (Miami, Florida); Roberta BRAMBILLA (Miami, Florida) |
| ABSTRACT | The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s). Also described herein are compositions and methods of use thereof for treating inflammasome related diseases or conditions. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/255653 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) A61K 39/3955 (20130101) A61K 39/39541 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 25/00 (20180101) A61P 25/14 (20180101) A61P 25/28 (20180101) A61P 29/00 (20180101) A61P 37/06 (20180101) Peptides C07K 16/18 (20130101) C07K 16/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284742 | Bruno et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); Los Angeles Biomedical Research Institute at Harbor at UCLA Medical Center (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent Bruno (Baltimore, Maryland); Tonya N. Watkins (Baltimore, Maryland); Ashraf Ibrahim (Irvine, California) |
| ABSTRACT | The invention provides a method of treating or preventing mucormycosis in a subject in need thereof, comprising administering to the subject a therapeutically-effective amount of an agent that inhibits a signaling pathway of a receptor selected from the group consisting of epidermal growth factor receptor, platelet derived growth factor receptor, ErbB2/Her2, progesterone receptor and a combination thereof. |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/255570 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/569 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 31/7048 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) Peptides C07K 16/2863 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284776 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Hua Wang (Cambridge, Massachusetts); David J. Mooney (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are compositions and methods for labeling cells using click chemistry reagents. The compositions and methods disclosed herein provide a specific and efficient means of localizing desired agents to a variety of cell types in vivo and in vitro. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/206050 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 49/221 (20130101) A61K 49/222 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) A61N 2007/0004 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Polysaccharides; Derivatives Thereof C08B 37/0006 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 251/00 (20130101) Original (OR) Class C08F 2438/03 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/548 (20130101) G01N 33/54346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284953 | Hasty et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeff Hasty (Encinitas, California); Lev Tsimring (San Diego, California); Spencer R. Scott (Rancho Santa Fe, California); Muhammad Omar Din (San Diego, California) |
| ABSTRACT | Provided are bacterial strains, methods of culturing bacterial cells using synthetic quorum-regulated lysis, and uses thereof. |
| FILED | Friday, May 18, 2018 |
| APPL NO | 16/614613 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/19 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284955 | Curtiss, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roy Curtiss, III (Gainesville, Florida); Shifeng Wang (Gainesville, Florida) |
| ABSTRACT | Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213619 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/08 (20130101) A61K 39/0275 (20130101) A61K 2039/522 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/36 (20130101) Original (OR) Class C12N 15/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284964 | Corvera |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Silvia Corvera (Westborough, Massachusetts) |
| ABSTRACT | Methods for preparation of prospectively identified human adipose stem cells enriched populations thereof, e.g., for therapy. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0653 (20130101) Original (OR) Class C12N 5/0692 (20130101) C12N 2501/11 (20130101) C12N 2501/105 (20130101) C12N 2501/115 (20130101) C12N 2501/119 (20130101) C12N 2501/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284978 | Kleinstiver et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Kleinstiver (Medford, Massachusetts); Russell T. Walton (Waban, Massachusetts) |
| ABSTRACT | Streptococcus pyogenes Cas9 (SpCas9) variants with relaxed PAM requirements capable of high-resolution editing for various applications, and methods of use thereof. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157708 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Enzymes C12Y 301/21004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284980 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | James Jefferson Smith (Morrisville, North Carolina); Derek Jantz (Durham, North Carolina); Homme W. Hellinga (Durham, North Carolina) |
| ABSTRACT | Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/210219 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/902 (20130101) C12N 15/905 (20130101) C12N 15/907 (20130101) C12N 15/8213 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284988 | Spiegel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (NEW HAVEN, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Spiegel (New Haven, Connecticut); Charles E. Jakobsche (Worcester, Massachusetts) |
| ABSTRACT | The present invention relates to chimeric (preferably, bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a patient or subject, especially including metastatic cancer where cancer cells exhibit ovrexpression (heightened expression) of cell surface urokinase-type plasminogen activator receptor (urokinase receptor) compared to normal (non-cancerous) cells. The compounds preferably covalently bind to the urokinase receptor and recruit native antibodies of the patient or subject where the antibodies can selectively degrade and/or deactivate targeted cancer cells through antibody-dependent cellular phagocytosis and/or antibody-dependent cellular cytotoxicity (ADCC) against a large number and variety of cancers, thus providing cancer cell death and/or an inhibition of growth, elaboration and/or metastasis of the cancer, including remission and cure of the patient's cancer. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/182437 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) A61K 31/352 (20130101) A61K 31/365 (20130101) A61K 38/05 (20130101) A61K 38/482 (20130101) A61K 45/06 (20130101) A61K 47/54 (20170801) A61K 47/60 (20170801) Acyclic or Carbocyclic Compounds C07C 279/12 (20130101) Heterocyclic Compounds C07D 491/107 (20130101) C07D 493/10 (20130101) Peptides C07K 5/06026 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/96 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284996 | JAFFREY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samie R. JAFFREY (New York, New York); Kate D. MEYER (New York, New York); Christophber E. MASON (New York, New York) |
| ABSTRACT | This invention relates to a method of characterizing the modified base status of a transcriptome, which involves contacting a transcriptome comprising one or more modified bases with an antibody specific to the modified bases under conditions effective to bind the antibody to the modified bases; isolating, from the transcriptome, a pool of RNA transcripts to which the antibody binds; and identifying isolated RNA transcripts that are present in a higher abundance in the isolated pool relative to the transcriptome, where each of the isolated RNA transcripts that are present in a higher abundance in the isolated pool together characterize the modified base status of the transcriptome. Also disclosed are a method of diagnosis or prognosis of a disease, a method of determining the effect of a treatment on modified base levels in RNA, and a kit for characterizing the modified base status of a transcriptome. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332446 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210285010 — COMPOSITIONS AND METHODS FOR IMPEDING TRANSCRIPTION OF EXPANDED MICROSATELLITE REPEATS
| US 20210285010 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Tzy-Shi Wang (Gainesville, Florida); Tanvi Saxena (Gainesville, Florida); Belinda Pinto (Gainesville, Florida); John Andrew Berglund (Gainesville, Florida) |
| ABSTRACT | Disclosed herein are compositions and methods for treating diseases characterized by expanded microsatellite repeats by impeding or inhibiting transcription of expanded microsatellite repeats. |
| FILED | Tuesday, October 31, 2017 |
| APPL NO | 16/346163 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 38/12 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2750/14123 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285013 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James M. Wilson (Philadelphia, Pennsylvania); Daniel J. Rader (Philadelphia, Pennsylvania) |
| ABSTRACT | Compositions and regimens useful in reducing one or more of: LDL-cholesterol, total cholesterol, and/or fasting triglycerides in a subject, and/or modifying fractional catabolic rate (FCR) of LDL apolipoprotein B (apoB) from baseline to a selected time point after rAAV administration are provided. The method involves administering to the human subject via a peripheral vein by infusion of a suspension of replication deficient recombinant adeno-associated virus (rAAV). |
| FILED | Tuesday, November 17, 2020 |
| APPL NO | 16/950272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 48/0091 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/06 (20180101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/861 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285015 | Musunuru et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kiran Musunuru (Cambridge, Massachusetts); Chad A. Cowan (Boston, Massachusetts); Derrick J. Rossi (Newton, Massachusetts) |
| ABSTRACT | Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells for treating or preventing genetic blood disorders. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/327606 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/907 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285031 | Woodward et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Joshua J. Woodward (Seattle, Washington); Alex Pollock (Seattle, Washington); Shivam Zaver (Seattle, Washington) |
| ABSTRACT | The disclosure provides fusion proteins useful for detecting and quantifying cyclic dinucleotides. The fusion proteins can comprise a functional cyclic dinucleotide binding domain linked to a first fluorescent domain and a second fluorescent domain. The first fluorescent domain and a second fluorescent domain can produce a detectable signal when brought into sufficiently close proximity, such as a FRET pair or split luciferase. The fusion protein can be used to assay the presence and/or concentration of cyclic dinucleotides in vitro or in a cell. The method of use include monitoring the cyclic dinucleotide activity, or activity of cyclic dinucleotide synthases. Furthermore, the methods can include screening compounds that may modulate cyclic dinucleotide activity, production, importation, and the like. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200503 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) C07K 14/4705 (20130101) C07K 2319/60 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6818 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285038 | Xie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Xiaoliang Sunney Xie (Lexington, Massachusetts); Dong Xing (Cambridge, Massachusetts); Chi-Han Chang (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides a method for genomic DNA amplification, such as whole genome amplification, including using a transposase system to make fragments of the genomic DNA including primer binding sites, isolating in oil each fragment within its own aqueous microdroplet along with PCR amplification reagents, amplifying each fragment within its own aqueous microdroplet, demulsifying the microdroplets to obtain the amplicons and sequencing the amplicons. |
| FILED | Wednesday, August 31, 2016 |
| APPL NO | 16/326405 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6853 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285045 | Giresi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Giresi (Palo Alto, California); Jason D. Buenrostro (Redwood City, California); Howard Y. Chang (Stanford, California); William J. Greenleaf (Menlo Park, California) |
| ABSTRACT | Provided herein is a method for analyzing polynucleotides such as genomic DNA. In certain embodiments, the method comprises: (a) treating chromatin isolated from a population of cells with an insertional enzyme complex to produce tagged fragments of genomic DNA; (b) sequencing a portion of the tagged fragments to produce a plurality of sequence reads; and (c) making an epigenetic map of a region of the genome of the cells by mapping information obtained from the sequence reads to the region. A kit for performing the method is also provided. |
| FILED | Monday, December 07, 2020 |
| APPL NO | 17/114278 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 2521/301 (20130101) C12Q 2537/164 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 30/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285050 | Klarin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek Klarin (Boston, Massachusetts); Scott M. Damrauer (Philadelphia, Pennsylvania); Christopher J. O'Donnell (Boston, Massachusetts); Philip S. Tsao (Palo Alto, California); Sekar Kathiresan (Boston, Massachusetts); Daniel J. Rader (Philadelphia, Pennsylvania); Peter W.F. Wilson (Decatur, Georgia); Themistocles L. Assimes (Palo Alto, California) |
| ABSTRACT | Disclosed are chimeric antigen receptor (CAR) polypeptides comprising a T cell receptor (TCR) antigen binding domain, a transmembrane domain, and an intracellular signaling domain. Disclosed are methods of making a CART cell comprising obtaining a cell from a subject diagnosed with T cell lymphoma; determining the sequence of the TCR on the cell; and transducing a T cell with a vector comprising a nucleic acid sequence that encodes a CAR polypeptide, wherein the CAR polypeptide comprises a TCR antigen binding domain, a transmembrane domain, and an intracellular signaling domain, wherein the TCR antigen binding domain is specific to a subsequence of the sequence of the TCR on the cell identified in the step of determining the sequence of the TCR |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/258084 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) A61K 31/7088 (20130101) A61K 38/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285052 | Bahrami et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Armita Bahrami (Memphis, Tennessee); Seung Jae Lee (Collierville, Tennessee) |
| ABSTRACT | A method for detecting methylated CpG sites located in the promoter of the Telomerase Reverse Transcriptase (TERT) gene, using the restriction enzymes BsiWI and Hpy188I or Hpy99I, is provided. A kit for carrying out the method and methods for diagnosing cancer and assessing whether a mammal with cancer is a candidate for treatment with a demethylating agent is also provided. |
| FILED | Tuesday, September 12, 2017 |
| APPL NO | 16/330444 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285062 | Jaeger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philipp Jaeger (La Jolla, California); Trey Ideker (La Jolla, California) |
| ABSTRACT | Disclosed herein are improved methods for fluorescence measurements in yeast colonies. |
| FILED | Tuesday, May 15, 2018 |
| APPL NO | 16/613931 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/06 (20130101) C12Q 1/6895 (20130101) Original (OR) Class C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285933 | BECKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Pamela BECKER (Seattle, Washington); Su-In LEE (Seattle, Washington); Carl BLAU (Seattle, Washington); Vivian OEHLER (Seattle, Washington); Timothy MARTINS (Seattle, Washington); Raymond J. MONNAT, Jr. (Seattle, Washington) |
| ABSTRACT | Described herein are functional cell assays and methods for selecting a personalized anti-cancer treatment regimen that can improve treatment of cancer in a subject, identify resistance of the subject's cancer to one or more anti-cancer agents and/or validate the current drug treatment strategy. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/257945 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class G01N 33/5073 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285938 | KEVIL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Christopher KEVIL (Shreveport, Louisiana); Elizabeth DISBROW (Shreveport, Louisiana); Johnathan Steven ALEXANDER (Shreveport, Louisiana); Karen Y. STOKES (Shreveport, Louisiana) |
| ABSTRACT | A method of diagnosing Alzheimer's disease and related dementias (ADRD) in a patient comprising obtaining a plasma sample from the patient; determining a level of a biochemical sulfide in the plasma sample from the subject by trapping volatilized H2S in the plasma sample using alkaline buffer with monobromobiamine, and detecting the level of biochemical sulfide in the plasma sample, the biochemical sulfide being one of acid-labile sulfide, bound sulfide, and total sulfide; and diagnosing the patient with ADRD when the level of the biochemical sulfide is at least an elevated threshold level for the biochemical sulfide. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200746 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) Original (OR) Class G01N 2496/00 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285944 | Singamaneni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Srikanth Singamaneni (St. Louis, Missouri); Rohit Gupta (St. Louis, Missouri); Jingyi Luan (St. Louis, Missouri); Shantanu Chakrabartty (St. Louis, Missouri); Erica Scheller (St. Louis, Missouri); Jeremiah Morrissey (St. Louis, Missouri); Yixuan Wang (St. Louis, Missouri); Zheyu Wang (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Srikanth Singamaneni (St. Louis, Missouri); Rohit Gupta (St. Louis, Missouri); Jingyi Luan (St. Louis, Missouri); Shantanu Chakrabartty (St. Louis, Missouri); Erica Scheller (St. Louis, Missouri); Jeremiah Morrissey (St. Louis, Missouri); Yixuan Wang (St. Louis, Missouri); Zheyu Wang (St. Louis, Missouri) |
| ABSTRACT | The present disclosure is directed to refreshable biosensors and methods for synthesizing and refreshing same. In some embodiments, the refreshable biosensor comprises a plasmonic nanoparticle and a biorecognition element, wherein the biorecognition element is encapsulated with at least one of an organosilica polymer layer or a metal organic framework (MOF). |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198823 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5436 (20130101) G01N 33/54346 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285952 | LYDEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David C. LYDEN (Old Chatham, New York); Haiying ZHANG (New York, New York) |
| ABSTRACT | The present invention is directed to methods of diagnosing, prognosing, and managing treatment of cancer in a subject. These methods involve selecting a subject having cancer and obtaining, from the selected subject a population of either exomeres having a diameter less than 50 nm, small exosomes having a diameter of 60-80 nm, or large exosomes having a diameter of 90-120 nm, The exomeres, small exosomes, or large exosomes are recovered from the sample, and the exomeres, small exosomes, or large exosomes or portions thereof are contacted with one or more reagents suitable to detect: (1) higher or lower levels, relative to a standard for subjects not having cancer, or the presence or absence, of one or more proteins contained in said exomeres, small exosomes, or large exosomes, (2) higher or lower levels, relative to a standard for subjects not having cancer, or the presence or absence, of one or more N-giyeans contained In said exomeres, small exosomes, or large exosomes, (3) higher or lower levels, relative to a standard for subjects not having cancer, or the presence or absence, of one or mom lipids contained in said exomeres, small exosomes, or large exosomes, (4) the presence or absence of one or mom genetic mutations in nucleic acid molecules associated with cancer and contained in said exomeres, small exosomes, or large exosomes, or (5) combinations thereof. Cancer is then diagnosed, prognosed, or treatment Is modified based on this information. |
| FILED | Monday, December 03, 2018 |
| APPL NO | 16/873700 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285959 | MESSMER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ABREOS BIOSCIENCES, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley T. MESSMER (San Diego, California); Dina UZRI (San Diego, California); Jessie-Farah FECTEAU (San Diego, California) |
| ABSTRACT | Methods and assays for detecting natalizumab in a sample, natalizumab-peptide complexes in a sample, and point-of-care devices for detecting natalizumab in a sample are described herein. |
| FILED | Friday, August 11, 2017 |
| APPL NO | 16/324878 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 2333/70546 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285965 | Hahn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| INVENTOR(S) | Sihoun Hahn (Clyde Hill, Washington); Christopher Collins (Seattle, Washington); Remwilyn Dayuha (Lynnwood, Washington); Fan Yi (Shoreline, Washington) |
| ABSTRACT | Clinical diagnosis and newborn screening for primary immunodeficiencies (PIDDs) is described. The PIDDs include X-linked chronic granulomatous disease (X-CGD), X-linked lymphoproliferative syndrome (XLP1; SH2D1A deficiency), familial hemophagocytic lymphohistiocytosis 2 (FHL2), ataxia telangiectasia (AT), common variable immunodeficiency (CVID; B-cell dysfunctions), severe combined immunodeficiency (SCID), adenosine deaminase (ADA) deficiency, and dedicator of cytokinesis 8 (DOCKS) deficiency. Additionally, cell specific markers for platelets (CD42), natural killer (NK) cells (CD56), and T cells (CD3epsilon and CD3delta) can be used as secondary markers to provide support for diagnosis of disease. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/191256 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2570/00 (20130101) G01N 2800/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285970 | Ranum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Laura Ranum (Gainesville, Florida); Tao Zu (Gainesville, Florida) |
| ABSTRACT | Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/322604 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Separation B01D 21/262 (20130101) Peptides C07K 16/18 (20130101) C07K 2317/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/285 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285973 | Federoff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia); University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | Georgetown University (Washington, District of Columbia); University of Rochester (Rochester, New York) |
| INVENTOR(S) | Howard J. Federoff (Irvine, California); Massimo S. Fiandaca (Irvine, California); Amrita K. Cheema (Potomac, Maryland); Mark E. Mapstone (Irvine, California) |
| ABSTRACT | The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's meta-bolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157932 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 33/6896 (20130101) G01N 2405/04 (20130101) G01N 2800/50 (20130101) G01N 2800/60 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285974 | GAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaohu GAO (Seattle, Washington); Junwei LI (Seattle, Washington) |
| ABSTRACT | This disclosure provides a method for polymerizing polyphenols to provide polyphenol polymers using peroxidase and similar catalysis. In various aspects, it provides a method for polymerizing a polyphenol (e.g., polydopamine or a derivative or conjugate thereof) on a surface comprising polymerizing the polyphenol, a method for detecting an analyte comprising polymerizing a polyphenol, and an assay kit comprising a polyphenol (e.g., dopamine or a dopamine derivative). In one embodiment, a method for polymerizing a polyphenol includes contacting the polyphenol and an oxidant with an enzyme having peroxidase-like activity, under conditions sufficient to polymerize the polyphenol. In another embodiment, a method for depositing a polyphenol polymer (e.g., a polydopamine) includes providing, at a target site, an enzyme having peroxidase-like activity immobilized at the surface; and polymerizing, at the target site, a polyphenol in the presence of an oxidant and the enzyme to provide the polyphenol polymer, deposited on the surface. |
| FILED | Monday, October 30, 2017 |
| APPL NO | 16/341273 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/535 (20130101) G01N 33/9413 (20130101) Original (OR) Class G01N 2333/72 (20130101) G01N 2333/475 (20130101) G01N 2333/4737 (20130101) G01N 2333/5751 (20130101) G01N 2333/96455 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286032 | METT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE MEDICAL COLLEGE OF WISCONSIN ,INC. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard R. METT (Cedarburg, Wisconsin); James S. HYDE (Dousman, Wisconsin); Jason W. SIDABRAS (Milwaukee, Wisconsin) |
| ABSTRACT | A resonant coil system with improved sensitivity and signal-to-noise performance is described. A primary coil is tuned to a first resonance frequency and inductively coupled to a secondary coil that is separately tuned to a second resonance frequency. The primary and secondary coils form a resonant system with a resonance frequency that is a function of the primary and secondary coil resonance frequencies. The resonance frequency of the coil system is less than both the primary resonance frequency and the secondary resonance frequency. The mutual inductance between the two coils is high and the resonance frequency of the coil system's parallel mode is well separated from that of the anti-parallel mode. |
| FILED | Monday, September 18, 2017 |
| APPL NO | 16/334505 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3415 (20130101) G01R 33/3635 (20130101) G01R 33/3642 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286859 | EUBANK et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Stephen EUBANK (Charlottesville, Virginia); Srini VENKATRAMANAN (Charlottesville, Virginia); Madhurima NATH (Charlottesville, Virginia); Yihui REN (Charlottesville, Virginia) |
| ABSTRACT | Embodiments disclose a system for determining a sensitivity of a networked system. The system identifies a vertex (V) that represents a constituent and a state of the constituent, and an interaction (E) between at least two Vs. An interaction-dependent function provides a probability that, when a perturbation occurs, a V will be in a certain state given that it is currently in a determined state and its neighbors are currently in determined states. A network reliability is used to determine a probability that a V's state holds when a perturbation occurs. The system evaluates only a certain amount of terms in a Taylor series from a sample, and identifies interpolating polynomials between the Taylor series. A cost function optimizes a property of the networked system for a fixed cost. The system perturbs the networked system until reliability is zero to estimate a sensitivity of the networked system. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185476 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/11 (20130101) Original (OR) Class G06F 17/17 (20130101) G06F 17/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210287367 | Meyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig H. Meyer (Charlottesville, Virginia); Anudeep Konda (Los Angeles, California); Christopher M. Kramer (Charlottesville, Virginia); Xue Feng (Charlottesville, Virginia) |
| ABSTRACT | In one aspect the disclosed technology relates to embodiments of a method which, includes acquiring magnetic resonance imaging data, for a plurality of images, of the heart of a subject. The method also includes segmenting, using cascaded convolutional neural networks (CNN), respective portions of the images corresponding to respective epicardium layers and endocardium layers for a left ventricle (LV) and a right ventricle (RV) of the heart. The segmenting is used for extracting biomarker data from segmented portions of the images and, in one embodiment, assessing hypertrophic cardiomyopathy from the biomarker data. The method further includes segmenting processes for T1 MRI data and LGE MRI data. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335518 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/029 (20130101) A61B 5/0263 (20130101) A61B 5/1071 (20130101) A61B 5/1075 (20130101) A61B 5/7267 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6228 (20130101) G06K 2209/051 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/13 (20170101) G06T 7/62 (20170101) G06T 7/70 (20170101) G06T 2207/10088 (20130101) G06T 2207/20084 (20130101) G06T 2207/30048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210287765 | BUNIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Collaborative Drug Discovery, Inc. (Burlingame, California) |
| ASSIGNEE(S) | Collaborative Drug Discovery, Inc. (Burlingame, California) |
| INVENTOR(S) | Barry A. BUNIN (Belmont, California); Peter GEDECK (Arlington, Virginia) |
| ABSTRACT | A method includes identifying, using one or more processors, a first plurality of fragments of a first structure graph representing a first chemical compound, and generating, using the one or more processors, a first plurality of subgraphs of the first structure graph based on the first plurality of fragments. The method includes generating, using the one or more processors, a first plurality of nodes based on the first plurality of subgraphs. The method includes arranging, using the one or more processors, the first plurality of nodes based on a number of the first plurality of fragments associated with each of the first plurality of subgraphs. The method includes connecting, using the one or more processors, the first plurality of nodes using a first plurality of edges and based on one or more reduced graph rules. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196420 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/9024 (20190101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/20 (20190201) G16C 20/70 (20190201) G16C 20/80 (20190201) Original (OR) Class G16C 20/90 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210282696 | FRANCIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph T. FRANCIS (Albany, New York); Venkata S. Aditya TARIGOPPULA (Albany, New York); Brandi T. MARSH (Albany, New York) |
| ABSTRACT | A reinforcement learning brain-machine interface (RL-BMI) can have a policy that governs how detected signals, emanating from a motor cortex of a subject's brain, are translated into action. The policy can be improved by detecting a motor signal having a characteristic and emanating from the motor cortex. The system can provide, to a device and based on (i) the motor signal and (ii) an instruction policy, a command signal resulting in a first action by a device. Additionally, an evaluation signal, emanating from the motor cortex in response to the first action, can also be detected. With the foregoing information, the system can adjust the policy based on the evaluation signal such that a subsequent motor signal, from the subject's brain, having the characteristic results in a second action, by the device, different from the first action, as needed. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/099376 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) A61B 5/369 (20210101) A61B 5/375 (20210101) Original (OR) Class Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/68 (20130101) A61F 2002/704 (20130101) A61F 2002/6827 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283174 | Yin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts); Coruna Medical LLC (Longmont, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia Yin (Winchester, Massachusetts); Kate Pate (Golden, Colorado); Sharon Lake (Longmont, Colorado); Mark Fontenot (Lafayette, Louisiana) |
| ABSTRACT | An oxygenated material for application to an alkali burn in an ocular region. The oxygenated material includes a supersaturated oxygen emulsion (SSOE) including perfluorodecalin (PFD) homogenized with a phospholipid and an emulsifying wax. The SSOE comprises a viscosity configured to deliver the SSOE to a site of the alkali burn and sustain a partial pressure of oxygen at the site at a level a plurality of times greater than an ambient partial pressure of oxygen for a plurality of hours. A pressurized dispensing canister is configured to house and dispense the SSOE directly on the site. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200253 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/12 (20130101) A61K 9/0048 (20130101) A61K 9/107 (20130101) A61K 33/00 (20130101) Original (OR) Class A61K 47/06 (20130101) A61K 47/24 (20130101) A61K 47/44 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283232 | McNeel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Madison Vaccines Inc. (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Doug McNeel (Madison, Wisconsin); Richard Lesniewski (Madison, Wisconsin) |
| ABSTRACT | Provided herein is technology relating to cancer treatment and prevention and particularly, but not exclusively, to compositions and methods related to therapies for prostate cancer. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313335 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/001163 (20180801) A61K 39/001193 (20180801) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/53 (20130101) A61K 2039/505 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/3069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283305 | Francis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Embody, Inc. (Norfolk, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. Francis (Norfolk, Virginia); Stella Petrova (Blacksburg, Virginia); Nicholas Thayer (Morrisville, North Carolina) |
| ABSTRACT | Implantable scaffolds made from biopolymer fibers. Biopolymer is dissolved in acid in a closed container made of materials inert to the acid and to the collagen to form a biopolymer solution. The solution is stirred, then centrifuged to degas it. The degassed solution is put into syringes on a holder. The number of syringes equals the number of fibers in the bundle. The syringes are mounted in a rotatable holder. Essentially equal quantities of degassed solution are extruded from the syringes to produce fibers, which are gathered and fed into a formation buffer bath. The fibers are kept taught after extrusion and dehydrated in a dehydrating solution in a dehydrating bath. The fibers are wound a collector to collect the bundle. Scaffolds then are made. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/328854 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 17/14 (20130101) A61L 17/105 (20130101) A61L 27/24 (20130101) Original (OR) Class A61L 27/386 (20130101) A61L 27/3804 (20130101) A61L 2430/10 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/02 (20130101) D01D 5/06 (20130101) D01D 5/38 (20130101) D01D 7/00 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283428 | Konofagou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Elisa Konofagou (New York, New York); Hermes Arytto Salles Kamimura (New York, New York); Stephen Alexander Lee (New York, New York) |
| ABSTRACT | The present subject matter relates to techniques for simultaneous monitoring and modulating target tissue. The disclosed system can include a focused ultrasound (FUS) stimulation probe for stimulating the target tissue, an imaging probe for obtaining ultrasound images of displacement on target tissue, and a processor configured to provide an image of target tissue within about 2 seconds from the stimulating. The imaging probe and the FUS stimulation probe are coaligned and include different center frequencies. |
| FILED | Wednesday, October 07, 2020 |
| APPL NO | 17/065230 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) Original (OR) Class A61N 2007/0026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283863 | Naraghi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Naraghi (Cypress, Texas); James G. Boyd, IV (Brenham, Texas); Jizhe Cai (College Station, Texas); Yijun Chen (College Station, Texas); John Michael Beckerdite (College Station, Texas) |
| ABSTRACT | A curing process includes providing a hybrid material comprising a conductive filler in contact with a thermosetting resin. In addition, the curing process includes passing an electric current through the hybrid material to provide Joule heating until a temperature of the hybrid material reaches a temperature above a curing temperature of the thermosetting resin. |
| FILED | Thursday, August 01, 2019 |
| APPL NO | 17/259974 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 63/0004 (20130101) B29C 63/0073 (20130101) B29C 70/025 (20130101) Original (OR) Class B29C 70/342 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2309/08 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0007 (20130101) D01D 5/24 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/08 (20130101) D01F 9/22 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 55/1656 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283869 | Liang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiyong Liang (Tallahassee, Florida); Gerald Horne (Tallahassee, Florida); Ayou Hao (Tallahassee, Florida); Claire Jolowsky (Tallahassee, Florida) |
| ABSTRACT | Methods of forming composite materials, which may include filament winding two or more carbon nanotube yarns to form one or more material layers, contacting the yarns with a resin, and applying one or more stretching forces to the material layers. Composite materials also are provided. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198861 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/56 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2307/04 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/005 (20130101) C08J 2379/08 (20130101) Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/16 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283896 | Nino et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Quest Integrated, LLC (Kent, Washington) |
| ASSIGNEE(S) | Quest Integrated, LLC (Kent, Washington) |
| INVENTOR(S) | Giovanni Nino (Issaquah, Washington); Tyler Blumenthal (Renton, Washington) |
| ABSTRACT | Systems and methods for printed multifunctional skin are disclosed herein. In one embodiment, a method of manufacturing a smart device includes providing a structure, placing a sensor over an outer surface of the structure, and placing conductive traces over the outer surface of the structure. The conductive traces electrically connect the sensor to electronics. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222746 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) B29C 70/882 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/34 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Original (OR) Class Aeroplanes; Helicopters B64C 3/26 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 45/00 (20130101) Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/46 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 1/14 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/2206 (20130101) G01L 1/2287 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 5/0016 (20130101) G01M 5/0083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284303 | OUYANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (Boca Raton, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bing OUYANG (Fort Pierce, Florida); Tsung-Chow SU (Boca Raton, Florida); Yanjun LI (Fort Pierce, Florida); Jordan THOMAS (Boca Raton, Florida) |
| ABSTRACT | Underwater Deployable Structures (UDSs) capable of achieving inflation via mechanical pumps, moisture-activated expanding foams, water swelling material, or a hybrid of a mechanical pump and water swelling material. Moisture expanding foams begin as polyurethane-based resins of low viscosity, and react in the presence of water to become solid foam. In their final forms, the foams exist as open- or closed-cell, and vary in strength, elasticity, and rigidity. Water swelling material is also disclosed wherein the water swelling material is capable of achieving expansion numerous (e.g., up to about 250) times its initial volume when in contact with water and can shrink back to its initial volume upon dehydration, making the UDSs reusable. A mechanical pump may optionally be used to assist in initial inflation until the water swelling material reaches full expansion. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226913 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 11/52 (20130101) Original (OR) Class Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284549 | Ravichandran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duraiswamy Ravichandran (College Station, Texas); V S Reddy Channu (College Station, Texas) |
| ASSIGNEE(S) | Texas Biochemicals Inc. (College Station, Texas) |
| INVENTOR(S) | Duraiswamy Ravichandran (College Station, Texas); V S Reddy Channu (College Station, Texas) |
| ABSTRACT | A method is provided for producing an article which is transparent to IR wavelength in the region of 4 μm to 9 μm. The method includes the steps of (a) Producing ultra-fine powders of ZnS, (b) followed by pretreatment of the ultra-fine powders under reduced gas conditions including H2, H2S, N2, Ar and mixtures there of (c) followed by vacuum (3×10−6 torr) treatment to remove oxygen and sulfates adsorbed to the surface disposing a plurality of nano-particles on a substrate, wherein said nanoparticles comprise ZnS with ultra-high purity of cubic phase; (b) subjecting the nano-particles to spark plasma sintering thereby producing a sintered ZnS product with IR transmission reaching 75% in the wavelength range of 4 μm to 9 μm. |
| FILED | Tuesday, December 27, 2016 |
| APPL NO | 15/390853 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 3/003 (20130101) B28B 11/243 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 9/08 (20130101) C01G 11/02 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2004/03 (20130101) C01P 2004/64 (20130101) C01P 2006/60 (20130101) C01P 2006/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284775 | Emami et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Roozbeh Emami (Tempe, Arizona); Yousif Alsaid (Los Angeles, California); Ximin He (Los Angeles, California); Daniel Aukes (Gilbert, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roozbeh Emami (Tempe, Arizona); Yousif Alsaid (Los Angeles, California); Ximin He (Los Angeles, California); Daniel Aukes (Gilbert, Arizona) |
| ABSTRACT | A hydrogel precursor composition includes 10 wt % to 40 wt % N-isopropylacrylamide, 0.5 wt % to 2 wt % N,N′-methylenebisacrylamide, a solvent, and a photoinitiator. The hydrogel precursor composition is photocurable and thermally responsive. A thermally responsive hydrogel is formed by photopolymerizing the hydrogel precursor composition. The thermally responsive hydrogel may be used to mimic the activity of muscle fibers. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 16/900441 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284789 | Sotzing |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory A. Sotzing (Storrs, Connecticut) |
| ABSTRACT | All organic, dielectric polymers with high discharge efficiency at elevated operation temperatures are reported. |
| FILED | Thursday, July 02, 2020 |
| APPL NO | 16/919339 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/124 (20130101) Original (OR) Class C08G 2261/60 (20130101) C08G 2261/90 (20130101) C08G 2261/418 (20130101) C08G 2261/3342 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 4/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284995 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Dehua Zhao (Brookline, Massachusetts); Christopher A. Voigt (Belmont, Massachusetts); Michael Joseph Smanski (Falcon Heights, Minnesota) |
| ABSTRACT | The invention relates to methods and products for generating diverse libraries of genetic material. The products include libraries and constructed nucleic acids as well as kits and databases and systems thereof. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204219 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/66 (20130101) C12N 15/1034 (20130101) C12N 15/1058 (20130101) C12N 15/1093 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/06 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 20/30 (20190201) G16B 35/00 (20190201) G16B 35/10 (20190201) G16B 35/20 (20190201) G16B 50/00 (20190201) G16B 50/30 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/60 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285404 | Garcia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northrop Grumman Systems Corporation (Plymouth, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin W.C. Garcia (Tremonton, Utah); Brian Christensen (Willard, Utah); David R. Nelson (Logan, None) |
| ABSTRACT | A multi-component structure includes a first hybrid metal composite structure, a second hybrid metal composite structure, and a joint structure. The first and second hybrid metal composite structures include layers, each layer comprising a fiber composite material structure including a fiber material dispersed within a matrix material and at least one metal ply located between layers of the layers. The joint structure extends between and connects the first hybrid metal composite structure and the second hybrid metal composite structure. Additionally, the joint structure exerts a clamping force on the first and second hybrid metal composite structures and to reduce gaps between the layers, between the layers and the at least one metal ply, and between the joint structure and the first and second hybrid metal composite structures to less than half a thickness of the at least one metal ply. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197994 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/08 (20130101) Cosmonautics; Vehicles or Equipment Therefor B64G 1/403 (20130101) Jet-propulsion Plants F02K 9/97 (20130101) F02K 9/343 (20130101) Original (OR) Class F02K 9/346 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2300/6032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285729 | Kasim |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Kawthar Kasim (Long Beach, California) |
| ABSTRACT | A tapered groove width heat pipe is disclosed, including a tube having an internal surface, a first end, a second end, and a central axis. A plurality of groove walls on the internal surface define a plurality of trapezoidal grooves. Each groove wall has a proximal width closest to the central axis and a distal width furthest from the central axis, the proximal width of a portion of each groove wall tapering gradually between the first end and the second end. |
| FILED | Monday, March 16, 2020 |
| APPL NO | 16/820701 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/04 (20130101) F28D 15/0233 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285817 | Laforge et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | François Laforge (East Windsor, New Jersey); Herschel Rabitz (Lawrenceville, New Jersey); Howard Y. Bell (Princeton, New Jersey); Joshua E. Collins (Philadelphia, Pennsylvania) |
| ABSTRACT | Disclosed is a system and method for shaped incoherent light for control (SILC). More particularly, disclosed is a method for controlling the evolution of photo-responsive systems (including chemical species, biochemical species or material compounds) using a device capable of producing shaped incoherent light for such control. The disclosed device integrates a polychromatic incoherent source in an adaptive feedback control loop. |
| FILED | Friday, May 17, 2019 |
| APPL NO | 17/260303 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) Original (OR) Class G01J 3/14 (20130101) G01J 3/42 (20130101) G01J 2003/423 (20130101) G01J 2003/1286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285952 | LYDEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David C. LYDEN (Old Chatham, New York); Haiying ZHANG (New York, New York) |
| ABSTRACT | The present invention is directed to methods of diagnosing, prognosing, and managing treatment of cancer in a subject. These methods involve selecting a subject having cancer and obtaining, from the selected subject a population of either exomeres having a diameter less than 50 nm, small exosomes having a diameter of 60-80 nm, or large exosomes having a diameter of 90-120 nm, The exomeres, small exosomes, or large exosomes are recovered from the sample, and the exomeres, small exosomes, or large exosomes or portions thereof are contacted with one or more reagents suitable to detect: (1) higher or lower levels, relative to a standard for subjects not having cancer, or the presence or absence, of one or more proteins contained in said exomeres, small exosomes, or large exosomes, (2) higher or lower levels, relative to a standard for subjects not having cancer, or the presence or absence, of one or more N-giyeans contained In said exomeres, small exosomes, or large exosomes, (3) higher or lower levels, relative to a standard for subjects not having cancer, or the presence or absence, of one or mom lipids contained in said exomeres, small exosomes, or large exosomes, (4) the presence or absence of one or mom genetic mutations in nucleic acid molecules associated with cancer and contained in said exomeres, small exosomes, or large exosomes, or (5) combinations thereof. Cancer is then diagnosed, prognosed, or treatment Is modified based on this information. |
| FILED | Monday, December 03, 2018 |
| APPL NO | 16/873700 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285973 | Federoff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgetown University (Washington, District of Columbia); University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | Georgetown University (Washington, District of Columbia); University of Rochester (Rochester, New York) |
| INVENTOR(S) | Howard J. Federoff (Irvine, California); Massimo S. Fiandaca (Irvine, California); Amrita K. Cheema (Potomac, Maryland); Mark E. Mapstone (Irvine, California) |
| ABSTRACT | The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's meta-bolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157932 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 33/6896 (20130101) G01N 2405/04 (20130101) G01N 2800/50 (20130101) G01N 2800/60 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286053 | PANAS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Government of the United States, as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Matthew PANAS (Dublin, California); Phillip Harris PAUL (San Francisco, California); Harris J. HALL (Yellow Springs, Ohio); Lavern A. STARMAN (Dayton, Ohio) |
| ABSTRACT | The present disclosure relates to an adaptive, free-space optical system. The system may have a controller and a digital micromirror (DMM) array responsive to the controller. The digital micromirror may include a plurality of independently controllable micromirror elements forming a receiver for receiving optical signals from an environmental scene. At least two of the plurality of independently controllable micromirror elements are steerable in different directions to receive optical signals emanating from two or more locations within the environmental scene. A beam steering subsystem forms a portion of the micromirror array and is in communication with the controller for receiving control signals from the controller. A detector is used to receive an incoming free space optical signal imaged by at least one of the micromirror elements. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/817256 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4817 (20130101) Original (OR) Class G01S 7/4863 (20130101) G01S 7/4868 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286067 | Harnett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas); The United States of America as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lumumba Harnett (Lawrence, Kansas); Justin G. Metcalf (Norman, Oklahoma); Shannon D. Blunt (Shawnee, Kansas) |
| ABSTRACT | The present application discloses a new form of μ-STAP, referred to herein as post μ-STAP or Pμ-STAP, which overcomes the drawbacks associated with existing μ-STAP techniques. The Pμ-STAP techniques described herein facilitate the generation of additional training data and homogenization after pulse compression. For example, Pμ-STAP techniques may apply a plurality of homogenization filters to a pulse compressed datacube generated from an input radar waveform, which produces a plurality of new pulse compressed datacubes with improved characteristics. Unlike existing μ-STAP techniques described above, which require prepulse compressed data to operate, the Pμ-STAP techniques disclosed in the present application are designed to utilize pulse compressed data, and therefore may be readily applied to legacy radar systems. |
| FILED | Tuesday, July 30, 2019 |
| APPL NO | 17/260078 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/288 (20130101) G01S 7/414 (20130101) G01S 7/415 (20130101) G01S 7/418 (20130101) G01S 7/2923 (20130101) G01S 13/5242 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286161 | Gardner |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis Gardner (Washington, District of Columbia) |
| ABSTRACT | Methods and apparatuses for imaging an incoherently illuminated object are provided. Image data recorded by an image detector is received. The image data comprises a plurality of images respectively corresponding to a plurality of scanning positions. Each image is produced in response to the image detector receiving incoherent light that has passed through an object and then been diffused by a scattering layer. A plurality of diffraction patterns respectively corresponding to the plurality of scanning positions are generated from the image data, and the image of the object is reconstructed based on the plurality of diffraction patterns and the plurality of scanning positions. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/331932 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) G02B 21/367 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/2256 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286168 | PANAS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Goverment of the United States, as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Matthew PANAS (Dublin, California); Harris J. HALL (Yellow Springs, Ohio); Lavern A. STARMAN (Dayton, Ohio) |
| ABSTRACT | The present disclosure relates to an imaging system which may make use of an electronic controller, a digital micromirror array, an aperture control system and a detector to image a desired scene. The digital micromirror array has a plurality of micromirror elements responsive to control signals generated by the electronic controller for electronically aiming the micromirror elements in a desired direction to image the desired area, and for receiving and reflecting light emanating from the desired area. The aperture control system receives light reflected from the digital micromirror array and passes a predetermined subportion of the received light therethrough. The detector is responsive to the predetermined subportion of light. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/817213 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 26/0833 (20130101) Original (OR) Class Transmission H04B 10/11 (20130101) H04B 10/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286188 | RUBIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Noah A. RUBIN (Cambridge, Massachusetts); Jan Philipp Balthasar MUELLER (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | An optical component comprises a metasurface comprising nanoscale elements. The metasurface is configured to receive incident light and to generate optical outputs. The geometries and/or orientations of the nanoscale elements provide a first optical output upon receiving a polarized incident light with a first polarization, and provide a second optical output upon receiving a polarized incident light with a second polarization that is different from the first polarization. |
| FILED | Thursday, August 24, 2017 |
| APPL NO | 16/327771 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/3083 (20130101) G02B 27/283 (20130101) G02B 27/286 (20130101) Original (OR) Class G02B 2207/101 (20130101) Holographic Processes or Apparatus G03H 1/0244 (20130101) G03H 2222/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286230 | Wong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Chee Wei Wong (Los Angeles, California); Shu-Wei Huang (Los Angeles, California); Abhinav Kumar Vinod (Los Angeles, California) |
| ABSTRACT | Systems and methods in accordance with embodiments of the invention implement all-microwave stabilized microresonator-based optical frequency comb. In one embodiment, an all-microwave stabilized microresonator-based optical frequency comb includes: an optical pump configured to generate pulses of light; a microresonator including an input configured to receive pulses generated by an optical pump and an output configured to generate an optical frequency comb signal characterized by frep and ξ; where frep describes spacing of frequency components in the optical frequency comb; where the optical frequency comb includes a primary comb and a plurality of subcombs and ξ is a frequency offset between subcombs; and two phase locked loops that phase lock frep and ξ to low noise microwave oscillators by modulating output power and pump frequency of the optical pump. |
| FILED | Thursday, August 17, 2017 |
| APPL NO | 16/326056 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3536 (20130101) Original (OR) Class G02F 2203/15 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/14 (20130101) H01S 5/0427 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286231 | Kolacz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jakub Kolacz (Washington, District of Columbia); Henry G. Gotjen (Washington, District of Columbia); Christopher M. Spillmann (Annandale, Virginia); Jawad Naciri (Arlington, Virginia); Jason D. Myers (Alexandria, Virginia); Jesse A. Frantz (Washington, District of Columbia); Robel Y. Bekele (Washington, District of Columbia) |
| ABSTRACT | A liquid crystal (LC) beam steerer includes a waveguide apparatus with a waveguide having a high-index core in contact with a variable-index liquid crystal (LC) cladding, wherein a voltage applied to the LC cladding is effective to steer a beam of light passing through the high-index core. Measuring the bulk birefringence and/or the capacitance characteristics of the LC can facilitate beam steering. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/036675 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0316 (20130101) G02F 1/365 (20130101) Original (OR) Class G02F 1/2955 (20130101) G02F 2202/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286740 | Dunning et al. |
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| FUNDED BY |
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| APPLICANT(S) | Qualcomm Intelligent Solutions, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Stewart Dunning (Portland, Oregon); Shekhar Yeshwant Borkar (Beaverton, Oregon); Nitin Yeshwant Borkar (Redmond, Washington); Matthew Scott Radecic (San Diego, California) |
| ABSTRACT | In-line memory module (IMM) computing nodes with an embedded processor(s) to support local processing of memory-based operations for lower latency and reduced power consumption, and related methods are disclosed. The IMM computing node that includes one or more memory chips mounted on a circuit board. The IMM computing node also includes one or more embedded processor(s) on the circuit board that are each interfaced to at least one memory chip among the one or more memory chips. The processor(s) can be configured to access its interfaced memory chip(s) through an internal memory bus on the circuit board to perform processing onboard the IMM computing node in an offload computing access mode. The embedded processors(s) can also be configured to forward memory access requests received from an external processor to the memory chip(s) for data storage and retrieval in a transparent access mode without further local processing of the memory access requests. |
| FILED | Monday, March 16, 2020 |
| APPL NO | 16/820572 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/1668 (20130101) Original (OR) Class G06F 13/4027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286859 | EUBANK et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Stephen EUBANK (Charlottesville, Virginia); Srini VENKATRAMANAN (Charlottesville, Virginia); Madhurima NATH (Charlottesville, Virginia); Yihui REN (Charlottesville, Virginia) |
| ABSTRACT | Embodiments disclose a system for determining a sensitivity of a networked system. The system identifies a vertex (V) that represents a constituent and a state of the constituent, and an interaction (E) between at least two Vs. An interaction-dependent function provides a probability that, when a perturbation occurs, a V will be in a certain state given that it is currently in a determined state and its neighbors are currently in determined states. A network reliability is used to determine a probability that a V's state holds when a perturbation occurs. The system evaluates only a certain amount of terms in a Taylor series from a sample, and identifies interpolating polynomials between the Taylor series. A cost function optimizes a property of the networked system for a fixed cost. The system perturbs the networked system until reliability is zero to estimate a sensitivity of the networked system. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185476 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/11 (20130101) Original (OR) Class G06F 17/17 (20130101) G06F 17/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286910 | Gecer Ulu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nurcan Gecer Ulu (Sunnyvale, California); Svyatoslav Korneev (Stanford, California); Saigopal Nelaturi (Mountain View, California); Erva Ulu (Sunnyvale, California) |
| ABSTRACT | A method for producing a design includes receiving a set of design constraints. A spatial field is created based on the design constraints. The spatial field is represented with a linear combination of one or more bases. A number of the one or more bases is less than a number of elements in the spatial field. Respective weights are optimized for each of the one or more bases. A design is produced based on the spatial field and the weights. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 16/818379 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/12 (20200101) Original (OR) Class G06F 2111/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210287785 | Fabbri et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Fabbri (Nashville, Tennessee); Joseph Coco (Nashville, Tennessee); Cheng Ye (Nashville, Tennessee); Deirdre Scully (Nashville, Tennessee); Candace McNaughton (Nashville, Tennessee); Jesse Ehrenfeld (Nashville, Tennessee); Christopher Simpson (Nashville, Tennessee); Laurie Novak (Nashville, Tennessee); Sean Bloos (Nashville, Tennessee); Robert Bodenheimer (Nashville, Tennessee); Richard Paris (Nashville, Tennessee); Julie A. Adams (Corvallis, Oregon); Jamison Heard (Corvallis, Oregon) |
| ABSTRACT | The present disclosure describes various embodiments of systems, apparatuses, and methods for automated sensing clinical documentation using machine learning. One such method comprises recording a video data feed of a patient being attended to by a medical personnel that is wearing at least one motion sensor; capturing a motion data feed of the medical personnel as the patient is being attended to by the medical personnel; analyzing the collected data feeds to prepare a clinical care record using machine learning algorithms; and transmitting the clinical care record to an upstream healthcare provider. Other methods and systems are also provided. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/203204 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/163 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00355 (20130101) G06K 9/00375 (20130101) G06K 9/00771 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 40/20 (20180101) Original (OR) Class G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210287826 | Tabor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher E. Tabor (Kettering, Ohio); Zachary J. Farrell (Xenia, Ohio); Nicholas J. Morris (Dayton, Ohio); Megan A. Creighton (Dayton, Ohio) |
| ABSTRACT | The present invention relates to core shell liquid metal encapsulates comprising and processes of making and using such encapsulates and networks. The shell(s) of such encapsulates employ a palette of materials having widely varied band structures and/or the desired spin pairing and/or bond polarization. Such encapsulates can be designed to respond to one or more stimuli of choice, including but not limited to electromagnetic, thermal, mechanical, photonic, and/or magnetic and are environmentally robust. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337874 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 26/00 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288261 | FORREST et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); Industry-Academic Cooperation Foundation, Dankook University (Gyeongii-do, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. FORREST (Ann Arbor, Michigan); Jun Yeob LEE (Gyeonggi-do, South Korea); Yong Joo CHO (Seoul, South Korea); Byung D. CHIN (Gyeonggi-do, South Korea) |
| ABSTRACT | Disclosed herein are organic photosensitive optoelectronic devices comprising two electrodes in superposed relation, a photoactive region located between the two electrodes, wherein the photoactive region comprises a donor mixture and an organic acceptor material, the donor mixture comprising at least one organic polymer donor material and at least one squaraine donor. Methods of fabricating the organic photosensitive optoelectronic devices are also disclosed. |
| FILED | Monday, October 19, 2020 |
| APPL NO | 16/949188 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/005 (20130101) H01L 51/0036 (20130101) H01L 51/0037 (20130101) H01L 51/0059 (20130101) Original (OR) Class H01L 51/424 (20130101) H01L 51/4253 (20130101) H01L 2251/308 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/549 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288267 | Forrest et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan); Yongxi Li (Ann Arbor, Michigan) |
| ABSTRACT | The present invention relates in part to an asymmetric non-fullerene acceptor compound for use in organic photovoltaic (OPV) devices. The invention also relates in part to an OPV device comprising an asymmetric non-fullerene acceptor compound. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 16/903874 |
| CURRENT CPC | Heterocyclic Compounds C07D 495/22 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/42 (20130101) H01L 51/0058 (20130101) H01L 51/0074 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288403 | Hassanien et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ahmed Hassanien (Savoy, Illinois); Michael Breen (Clarksville, Maryland); Ming-Huang Li (Pingtung County, Taiwan); Songbin Gong (Champaign, Illinois) |
| ABSTRACT | An antenna includes a piezoelectric disc. The antenna further includes a first electrode disposed on a first surface of the piezoelectric disc and a second electrode disposed on a second surface of the piezoelectric disc that is opposite to the first surface. The first electrode and the second electrode are to receive a time-varying voltage to excite a mechanical vibration in the piezoelectric disc, and the piezoelectric disc is to radiate electromagnetic energy at a particular frequency responsive to the mechanical vibration. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/249672 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/38 (20130101) H01Q 1/50 (20130101) H01Q 3/01 (20130101) Original (OR) Class H01Q 9/0407 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/725 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288471 | Deppe |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dennis Glenn Deppe (Oviedo, Florida) |
| ASSIGNEE(S) | Dennis Glenn Deppe (Oviedo, Florida) |
| INVENTOR(S) | Dennis Glenn Deppe (Oviedo, Florida) |
| ABSTRACT | A semiconductor vertical resonant cavity light source includes an upper and lower mirror that define a vertical resonant cavity. An active region is within the cavity for light generation between the upper and lower mirror. At least one cavity spacer region is between the active region and the upper mirror or lower mirror. The cavity includes an inner mode confinement region and an outer current blocking region. An index guide in the inner mode confinement region is between the cavity spacer region and the upper or lower mirror. The index guide and outer current blocking region each include a lower and upper epitaxial material layer thereon with an epitaxial interface region in between. At least a top surface of the lower material layer includes aluminum in the interface region throughout a full area of an active part of the vertical light source. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135934 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/183 (20130101) H01S 5/187 (20130101) H01S 5/1833 (20130101) H01S 5/2018 (20130101) H01S 5/2059 (20130101) H01S 5/2063 (20130101) H01S 5/2072 (20130101) H01S 5/2086 (20130101) H01S 5/18308 (20130101) H01S 5/18327 (20130101) H01S 5/18333 (20130101) Original (OR) Class H01S 5/18358 (20130101) H01S 5/18361 (20130101) H01S 5/18391 (20130101) H01S 2301/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288685 | MEDARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); National University of Ireland, Maynooth (Maynooth, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Muriel MEDARD (Belmont, Massachusetts); Kenneth R. DUFFY (Dublin, Ireland); Amit SOLOMON (Cambridge, Massachusetts); Alejandro COHEN (Brookline, Massachusetts) |
| ABSTRACT | Described are concepts, systems, devices and methods that enhance decoding performance of channels subject to correlated noise. The concepts, systems, devices and methods can be used with any combination of codes, code-rates and decoding techniques. In embodiments, a continuous realization of effective noise is estimated from a lead channel by subtracting its decoded output from its received signal. This estimate is then used to improve the accuracy of decoding of an otherwise orthogonal channel that is experiencing correlated effective noise. In this approach, channels aid each other through the post-decoding provision of estimates of effective noise. In some embodiments, the lead channel is not pre-determined, but is chosen dynamically based on which of a plurality of decoders completes first, or using soft information including an estimate of effective noise that is least energetic or most likely to have occurred. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/202860 |
| CURRENT CPC | Transmission H04B 1/123 (20130101) Original (OR) Class H04B 1/1027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288984 | JONES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Aerospace Corporation (El Segundo, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Neal JONES (Santa Clarita, California); Nicholas Cameron COHEN (Long Beach, California); Jonathan LIN (El Segundo, California); Douglas Robert WOODWARD (Redondo Beach, California); Jacquelyn Christina ANDRADE (Rancho Cucamonga, California); Eric John MCDONALD (Newbury Park, California); Michael Harvey COLE (Torrance, California) |
| ABSTRACT | Space system TT&C monitoring includes analyzing network traffic comprising of data packets between a front-end processor (FEP) and a cryptographic unit. A JavaScript Object Notation (JSON) object is created when the network traffic containing a vehicle command is detected. The JSON object is transmitted, by way of a data transport mechanism, to either a cyber defense module or a security information and event management (SIEM) module for further ingestions and visualization. The JSON object is analyzed using machine learning (ML) module or a rule-based intrusion detection system (IDS) module to generate an anomaly score for the SIEM module for further ingestions and visualization. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/817503 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/602 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 43/08 (20130101) H04L 63/145 (20130101) H04L 63/1425 (20130101) Original (OR) Class H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210283115 | Abergel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca J. Abergel (Kensington, California); Taylor A. Choi (South San Francisco, California); Kenneth N. Raymond (Berkeley, California); David K. Shuh (Oakland, California) |
| ABSTRACT | Provided herein are pharmaceutical formulations comprising a 1,2-HOPO chelating agent and/or 3,2-HOPO chelating agent. |
| FILED | Tuesday, September 05, 2017 |
| APPL NO | 16/330601 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0056 (20130101) A61K 9/0095 (20130101) A61K 9/1611 (20130101) A61K 9/1623 (20130101) A61K 9/1652 (20130101) A61K 9/2009 (20130101) A61K 9/2018 (20130101) A61K 9/2054 (20130101) A61K 31/444 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283551 | Snow et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mathew S. Snow (Idaho Falls, Idaho); Jessica L. Ward (Idaho Falls, Idaho) |
| ABSTRACT | Systems and methods for efficient, effective, and safe separation and isolation of multiple isotopes (e.g., Mo, Zr, Ba, Sr, Te, and lanthanide isotopes) from fission products includes use of a plurality of chromatography columns, each containing a chromatographic resin formulated to target one or more particular isotopes. The system is operable in a “series” configuration to load the multiple columns by a single pass of the sample. Then, the system may be transitioned (e.g., using valves) to a “parallel” configuration in which multiple columns of the system may be operated simultaneously to elute targeted isotopes. Additional parallel operations of the columns, using different eluent compositions, may be used to elute different targeted isotopes. The system may be reconditioned in preparation for a subsequent sample. |
| FILED | Thursday, January 21, 2021 |
| APPL NO | 17/154658 |
| CURRENT CPC | Separation B01D 15/22 (20130101) B01D 15/24 (20130101) B01D 59/30 (20130101) Original (OR) Class Production and Refining of Metals; Pretreatment of Raw Materials C22B 60/0265 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283587 | GUNNOE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | THOMAS B. GUNNOE (PALMYRA, Virginia); BENJAMIN AUSTIN VAUGHAN (DOVER, New Hampshire); MICHAEL S. WEBSTER-GARDINER (MIMS, Florida) |
| ABSTRACT | Embodiments of the present disclosure provide for Rh(I) catalysts, methods of making alkenyl substituted arenes (e.g., allyl arene, vinyl arene, and the like), methods of making alkyl substituted arenes, and the like. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188535 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/00 (20130101) B01J 31/189 (20130101) B01J 31/1815 (20130101) Original (OR) Class B01J 31/2226 (20130101) B01J 31/2291 (20130101) B01J 2231/46 (20130101) B01J 2531/0244 (20130101) B01J 2531/822 (20130101) B01J 2540/22 (20130101) B01J 2540/225 (20130101) Acyclic or Carbocyclic Compounds C07C 2/66 (20130101) C07C 5/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284526 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Jin Wang (Hinsdale, Illinois); Donald A. Walko (Woodridge, Illinois); Pice Chen (Lemont, Illinois); IL Woong Jung (Lemont, Illinois); Daniel Lopez (Lemont, Illinois) |
| ABSTRACT | A microelectromechanical device for diffracting optical beams comprises a diffractive element suspended over a channel. The diffractive element is configured to receive an optical beam and diffract and/or transmit the optical beam based on an orientation of the diffractive element. At least one torsional actuator is operatively connected to the diffractive element. The at least one torsional actuator is configured to selectively adjust the orientation of the diffractive element. The diffractive element has a diffractive element resonant frequency that is nearly the same as a resonant frequency of the optical beam. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196710 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0083 (20130101) Original (OR) Class B81B 2201/047 (20130101) Optical Elements, Systems, or Apparatus G02B 27/4233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284676 | Sathitsuksanoh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Noppadon Sathitsuksanoh (Louisville, Kentucky); Ning Sun (Fremont, California); Jian Shi (Albany, California); Anthe George (San Francisco, California); Manali Sawant (Cupertino, California); Seema Singh (Clarksburg, Maryland); Blake Simmons (San Francisco, California) |
| ABSTRACT | The present invention provides novel and improved processes for treating a lignocellulosic biomass or technical lignin using ionic liquids to obtain lignin breakdown products and polysaccharide biomass components. Recycling of ionic liquids can be included in the methods of the invention. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/189998 |
| CURRENT CPC | Compounds of Unknown Constitution C07G 1/00 (20130101) Original (OR) Class Production of Cellulose by Removing Non-cellulose Substances From Cellulose-containing Materials; Regeneration of Pulping Liquors; Apparatus Therefor D21C 3/20 (20130101) D21C 11/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284784 | Allen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Saudi Aramco Technologies Company (Dhahran, Saudi Arabia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott D. Allen (Fairport, New York); Wayne R. Willkomm (Ithaca, New York) |
| ABSTRACT | The present invention encompasses polyurethane compositions comprising aliphatic polycarbonate chains. In one aspect, the present invention encompasses polyurethane foams, thermoplastics and elastomers derived from aliphatic polycarbonate polyols and polyisocyanates wherein the polyol chains contain a primary repeating unit having a structure: In another aspect, the invention provides articles comprising the inventive foam and elastomer compositions as well as methods of making such compositions. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/195740 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/14 (20130101) Original (OR) Class C08G 18/44 (20130101) C08G 18/165 (20130101) C08G 18/246 (20130101) C08G 18/1833 (20130101) C08G 18/2081 (20130101) C08G 18/7664 (20130101) C08G 18/7671 (20130101) C08G 64/34 (20130101) C08G 64/183 (20130101) C08G 64/0208 (20130101) C08G 2110/0008 (20210101) C08G 2110/0025 (20210101) C08G 2110/0066 (20210101) C08G 2110/0083 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284972 | Huang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jing Huang (Berkeley, California); Zhennan Liu (Berkeley, California); Douglas S. Clark (Orinda, California); Jay D. Keasling (Berkeley, California); Aindrila Mukhopadhyay (Oakland, California); John F. Hartwig (Berkeley, California) |
| ABSTRACT | The present invention provides for a genetically modified host cell capable of producing an unnatural compound, such as terpenoid, comprising a P450 enzyme comprising an artificial cofactor, and the host cell is capable of uptaking the artificial cofactor by comprising a heterologous heme transport transmembrane protein, or homologue thereof. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200715 |
| CURRENT CPC | Heterocyclic Compounds C07D 487/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/10 (20130101) Original (OR) Class C12N 9/0069 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284981 | Doudna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Jillian F. Banfield (Berkeley, California); David Burstein (Berkeley, California); Steven C. Strutt (Berkeley, California); Lucas Benjamin Harrington (Berkeley, California) |
| ABSTRACT | The present disclosure provides CasX proteins, nucleic acids encoding the CasX proteins, and modified host cells comprising the CasX proteins and/or nucleic acids encoding same CasX proteins are useful in a variety of applications, which are provided. The present disclosure provides CasX guide RKAs that bind to and provide sequence specificity to the CasX proteins, nucleic acids encoding the CasX guide RNAs, and modified host cells comprising the CasX guide RNAs and/or nucleic acids encoding same. CasX guide RNAs are useful in a variety of applications, which are provided. The present disclosure provides archaeal Cas9 polypeptides and nucleic acids encoding same, as well as their associated archaeal Cas9 guide RNAs and nucleic acids encoding same. |
| FILED | Tuesday, July 23, 2019 |
| APPL NO | 17/258047 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0008 (20130101) Peptides C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285019 | BECKHAM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregg Tyler BECKHAM (Golden, Colorado); Thelhawadigedara Lahiru Niroshan JAYAKODY (Wheat Ridge, Colorado); Adam Michael GUSS (Oak Ridge, Tennessee); Thomas David MAND (Oak Ridge, Tennessee); Christopher W. JOHNSON (Denver, Colorado); Isabel PARDO MENDOZA (Dos Hermanas, Spain); Allison Jean ZIMONT WERNER (Denver, Colorado) |
| ABSTRACT | Disclosed herein are methods and compositions for catalytic glycolysis to deconstruct PET to bis(2-hydroxyethyl) terephthalate (BHET). For BHET conversion to terephthalate and ethylene glycol, we engineer Pseudomonas putida KT2440 with PETase and MHETase enzymes from Ideonella sakaiensis. We further engineer P. putida to convert terephthalate to a performance-advantaged bioproduct, β-ketoadipic acid, and for improved utilization of ethylene glycol, a byproduct of BHET catabolism. In a bioreactor, we produce 15.1±0.6 g/L of β-ketoadipic acid (βKA) from BHET at 76±3% molar yield. Lastly, we demonstrate conversion of catalytically depolymerized PET to βKA. Overall, this work highlights the potential of tandem catalytic deconstruction and biological conversion as a means to upcycle waste PET. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/198230 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/18 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/62 (20130101) Original (OR) Class Enzymes C12Y 301/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285076 | Plotkowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alexander J. Plotkowski (Knoxville, Tennessee); Sumit Bahl (Knoxville, Tennessee); Ryan R. Dehoff (Knoxville, Tennessee); James A. Haynes (Knoxville, Tennessee); Amit Shyam (Knoxville, Tennessee); Kevin D. Sisco (Tullahoma, Tennessee); Ying Yang (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander J. Plotkowski (Knoxville, Tennessee); Sumit Bahl (Knoxville, Tennessee); Ryan R. Dehoff (Knoxville, Tennessee); James A. Haynes (Knoxville, Tennessee); Amit Shyam (Knoxville, Tennessee); Kevin D. Sisco (Tullahoma, Tennessee); Ying Yang (Knoxville, Tennessee) |
| ABSTRACT | Aluminum-copper-manganese-zirconium alloys for metal additive manufacturing include 5 wt % to 35 wt % copper, 0.05 wt % to 3 wt % manganese, 0.5 wt % to 5 wt % zirconium, 0 wt % to 3 wt % iron, and 0 wt % to less than 1 wt % silicon, with the balance being aluminum. The as-printed alloys may have a microstructure comprising θ′ intermetallic precipitates having an average diameter of 0.1 μm to 0.3 μm, a microstructure comprising θ intermetallic particles having particle spacing of 50-500 nm with a volume fraction of 0-50%; a microstructure comprising a bimodal distribution of equiaxed grains and columnar grains, or any combination thereof. The as-printed alloys may exhibit superior mechanical properties compared to cast alloys with a similar composition. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188952 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Alloys C22C 1/0416 (20130101) C22C 21/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285077 | Shyam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Amit Shyam (Knoxville, Tennessee); Sumit Bahl (Knoxville, Tennessee); James A. Haynes (Knoxville, Tennessee); Yukinori Yamamoto (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Shyam (Knoxville, Tennessee); Sumit Bahl (Knoxville, Tennessee); James A. Haynes (Knoxville, Tennessee); Yukinori Yamamoto (Oak Ridge, Tennessee) |
| ABSTRACT | Disclosed herein are embodiments of an Al—Cu—Mn—Zr alloy for use with casting processes. The disclosed alloy embodiments provide fabricated objects, such as cast engine components comprising a heterogeneous microstructure and having good castability, resistance to hot tearing, and high ductility at room temperature. Methods for making and using alloy embodiments also are disclosed herein. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/189181 |
| CURRENT CPC | Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 17/00 (20130101) B22D 21/007 (20130101) Alloys C22C 1/03 (20130101) C22C 1/026 (20130101) C22C 21/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285330 | Hart et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Clifford Hart (Greenville, South Carolina); Jing Li (Niskayuna, New York); Suryarghya Chakrabarti (Niskayuna, New York); James Tyson Balkcum, III (Taylors, South Carolina); Markus Feigl (Simpsonville, South Carolina) |
| ABSTRACT | The present embodiments set forth a blade including an airfoil, the airfoil including a tip cap, a pressure sidewall and a suction sidewall extending axially between corresponding leading and trailing edges and radially between the base and the tip cap. The blade, including the airfoil and base, being formed in at least two airfoil parts, each of the two airfoil parts including contacting edges engaging each other respective contacting edges, the contacting edges defining a joint for preloading each of the at least two parts with each other and with the base. The at least two airfoil parts forming the airfoil being retained to each other by an interference fit at the joint. The interference fit providing frictional damping of vibrations in the blade during blade operation. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/816568 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/16 (20130101) Original (OR) Class F01D 5/18 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/30 (20130101) F05D 2240/30 (20130101) F05D 2260/96 (20130101) F05D 2260/221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285364 | Lusardi |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Caterpillar Inc. (Peoria, Illinois) |
| ASSIGNEE(S) | Caterpillar Inc. (Peoria, Illinois) |
| INVENTOR(S) | Christopher Lusardi (Peoria, Illinois) |
| ABSTRACT | An engine system includes an internal combustion engine having an intake passage, a first set of combustion chambers, a second set of combustion chambers, a first exhaust passage fluidly connected to the first set of combustion chambers, and a second exhaust passage fluidly connected to the second set of combustion chambers. The engine system includes a first turbocharger including a first compressor and a first turbine. The engine system also includes a second turbocharger including a second compressor and a second turbine, the second compressor connected in series with the first compressor, and the second turbine being in fluid communication with the second exhaust passage. The first and second turbines are connected in parallel such that the first turbine only receives exhaust flow from the first set of combustion chambers, and the second turbine only receives exhaust flow from the second set of combustion chambers. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333769 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/14 (20130101) Internal-combustion Piston Engines; Combustion Engines in General F02B 37/001 (20130101) Original (OR) Class F02B 37/013 (20130101) F02B 37/24 (20130101) Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof F02M 26/08 (20160201) Non-positive-displacement Pumps F04D 29/2216 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/04111 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285727 | AUTE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Heat Transfer Technologies, LLC (Prospect Heights, Illinois) |
| ASSIGNEE(S) | University of Maryland, College Park (, None); Heat Transfer Technologies, LLC (, None) |
| INVENTOR(S) | Vikrant C. AUTE (Jessup, Maryland); Daniel Fernandes BACELLAR (Silver Spring, Maryland); K. Reinhard RADERMACHER (Silver Spring, Maryland); James M. TANCABEL (College Park, Maryland); Jiazhen LING (Ellicott City, Maryland); Yoram Leon SHABTAY (Prospect Heights, Illinois); Jan MUEHLBAUER (Fulton, Maryland) |
| ABSTRACT | A heat exchanger has first and second manifold portions and an array of substantially-parallel heat-transfer tubes extending between the first and second manifold portions. Each heat-transfer tube has an outer surface and an inner surface defining a conduit. In a cross-sectional view, the outer surface of each heat-transfer tube can form a first shape that is non-circular, and the inner surface of heat-transfer tube can form a second shape different than the first shape. Alternatively or additionally, at least one of the first shape and the second shape lacks reflectional symmetry in the cross-sectional view. Methods for fabricating such heat exchangers are also provided. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196894 |
| CURRENT CPC | Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 15/26 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 7/16 (20130101) Original (OR) Class Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 9/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285729 | Kasim |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Kawthar Kasim (Long Beach, California) |
| ABSTRACT | A tapered groove width heat pipe is disclosed, including a tube having an internal surface, a first end, a second end, and a central axis. A plurality of groove walls on the internal surface define a plurality of trapezoidal grooves. Each groove wall has a proximal width closest to the central axis and a distal width furthest from the central axis, the proximal width of a portion of each groove wall tapering gradually between the first end and the second end. |
| FILED | Monday, March 16, 2020 |
| APPL NO | 16/820701 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/04 (20130101) F28D 15/0233 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285883 | Vasdekis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Idaho (Moscow, Idaho) |
| ASSIGNEE(S) | University of Idaho (, None) |
| INVENTOR(S) | Andreas E. Vasdekis (Moscow, Idaho); Nava Subedi (Moscow, Idaho); Shahla Nemati (Moscow, Idaho) |
| ABSTRACT | Certain disclosed embodiments concern an integrated imaging system that combined light-sheet microscopy, which enables considerable speed and phototoxicity gains, with quantitative-phase imaging. A method for using such imaging systems also is disclosed. In an exemplary embodiment, an integrated imaging system was used for multivariate investigation of live-cells in microfluidics. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/199934 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 21/6486 (20130101) Original (OR) Class G01N 2021/6471 (20130101) G01N 2201/0675 (20130101) Optical Elements, Systems, or Apparatus G02B 21/008 (20130101) G02B 21/025 (20130101) G02B 21/26 (20130101) G02B 21/0048 (20130101) G02B 21/0056 (20130101) G02B 21/0064 (20130101) G02B 21/0076 (20130101) G02B 21/0088 (20130101) Pictorial Communication, e.g Television H04N 5/247 (20130101) H04N 5/2256 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286053 | PANAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Government of the United States, as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Matthew PANAS (Dublin, California); Phillip Harris PAUL (San Francisco, California); Harris J. HALL (Yellow Springs, Ohio); Lavern A. STARMAN (Dayton, Ohio) |
| ABSTRACT | The present disclosure relates to an adaptive, free-space optical system. The system may have a controller and a digital micromirror (DMM) array responsive to the controller. The digital micromirror may include a plurality of independently controllable micromirror elements forming a receiver for receiving optical signals from an environmental scene. At least two of the plurality of independently controllable micromirror elements are steerable in different directions to receive optical signals emanating from two or more locations within the environmental scene. A beam steering subsystem forms a portion of the micromirror array and is in communication with the controller for receiving control signals from the controller. A detector is used to receive an incoming free space optical signal imaged by at least one of the micromirror elements. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/817256 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4817 (20130101) Original (OR) Class G01S 7/4863 (20130101) G01S 7/4868 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286168 | PANAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Goverment of the United States, as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Matthew PANAS (Dublin, California); Harris J. HALL (Yellow Springs, Ohio); Lavern A. STARMAN (Dayton, Ohio) |
| ABSTRACT | The present disclosure relates to an imaging system which may make use of an electronic controller, a digital micromirror array, an aperture control system and a detector to image a desired scene. The digital micromirror array has a plurality of micromirror elements responsive to control signals generated by the electronic controller for electronically aiming the micromirror elements in a desired direction to image the desired area, and for receiving and reflecting light emanating from the desired area. The aperture control system receives light reflected from the digital micromirror array and passes a predetermined subportion of the received light therethrough. The detector is responsive to the predetermined subportion of light. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/817213 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 26/0833 (20130101) Original (OR) Class Transmission H04B 10/11 (20130101) H04B 10/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210287822 | Despotopulos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL LABORATORY (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Despotopulos (Livermore, California); Carlos Valdez (San Ramon, California); Kelly Nora Kmak (Berkeley, California) |
| ABSTRACT | Provided herein are methods of isolating and using radioactive mercury. In particular, provided herein are methods of isolating radioactive mercury including the use of a thiacrown ether, and using the isolated radioactive mercury in therapeutic and/or imaging applications. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/816822 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1001 (20130101) A61N 2005/1019 (20130101) Conversion of Chemical Elements; Radioactive Sources G21G 1/001 (20130101) Original (OR) Class G21G 4/08 (20130101) G21G 2001/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288194 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhong Lin Wang (Atlanta, Georgia); Haiyang Zou (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides an alternating current (AC) generator comprising a substrate comprising a first material abutting a second material and forming an interface, wherein the first material comprises a first electrode and the second material comprises a second electrode in electrical communication with the first electrode, and wherein the substrate is configured to generate AC when the interface is exposed to periodic light stimulation. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/203417 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/02008 (20130101) H01L 31/02021 (20130101) H01L 31/022425 (20130101) Original (OR) Class Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288267 | Forrest et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Forrest (Ann Arbor, Michigan); Yongxi Li (Ann Arbor, Michigan) |
| ABSTRACT | The present invention relates in part to an asymmetric non-fullerene acceptor compound for use in organic photovoltaic (OPV) devices. The invention also relates in part to an OPV device comprising an asymmetric non-fullerene acceptor compound. |
| FILED | Wednesday, June 17, 2020 |
| APPL NO | 16/903874 |
| CURRENT CPC | Heterocyclic Compounds C07D 495/22 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/42 (20130101) H01L 51/0058 (20130101) H01L 51/0074 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288315 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Yingchao Yu (Ithaca, New York); Weidong Zhou (Ithaca, New York); Hao Chen (Ithaca, New York); Hector D. Abruna (Ithaca, New York) |
| ABSTRACT | A nanoparticle and a method for fabricating the nanoparticle utilize a decomposable material yoke located within permeable organic polymer material shell and separated from the permeable organic polymer material shell by a void space. When the decomposable material yoke comprises a sulfur material and the permeable organic polymer material shell comprises a material permeable to both a sulfur material vapor and a lithium ion within a battery electrolyte the nanoparticle may be used within an electrode for a Li/S battery absent the negative effects of battery electrode materials expansion. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197673 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/0404 (20130101) H01M 4/602 (20130101) H01M 4/1395 (20130101) H01M 4/1397 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288451 | TRENBATH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thien-Kim Leckie TRENBATH (Boulder, Colorado); William Cook LIVINGOOD, III (Lakewood, Colorado); Amy LeBAR (Golden, Colorado); Bennett R. DOHERTY (Bedford, New Hampshire) |
| ABSTRACT | The present disclosure relates to a plug load management system having automatic and dynamic load detection, meaning it has the ability to identify devices that are plugged into outlets of a building and determine the location of the plug load down to the specific outlet. When a device is moved, the plug load management system can determine this change and update accordingly. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198721 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/6683 (20130101) H01R 13/6691 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288593 | BURKES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KLAEHN W. BURKES (WAGENER, Georgia); VINCENT J. CEYSSENS (AUGUSTA, Georgia); JOHAN H.R. ENSLIN (CHARLESTON, South Carolina); MOAZZAM NAZIR (CHARLESTON, South Carolina) |
| ABSTRACT | A power transmission system can include a transformer and compensator circuit(s), each coupled between a node of the transformer and a ground connection. The compensator circuit(s) can each be configured to counteract a DC signal component of an AC signal at the transformer. The compensator circuit(s) can include a converter circuit having an AC side and a DC side and configured to convert a DC voltage on the DC side to an AC signal at the AC side. The compensator circuit(s) can include a DC link coupled to the DC side of the converter circuit. The compensator circuit(s) can include a controller configured to measure a DC signal component between the load and the ground; to determine, based at least in part on the DC signal component, a compensating signal configured to counteract the DC signal component; and to inject, by the converter circuit, the compensating signal to counteract the DC signal component. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196152 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/537 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288815 | Murialdo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maxwell R. Murialdo (Westminster, California); Brian Giera (San Mateo, California); Brian M. Howell (Livermore, California); Robert M. Panas (Dublin, California) |
| ABSTRACT | Systems and methods performed for generating authentication information for an image using optical computing are provided. When a user takes a photo of an object, an optical authentication system receives light reflected and/or emitted from the object. The system also receives a random key from an authentication server. The system converts the received light to plenoptic data and uploads it to the authentication server. In addition, the system generates an optical hash of the received light using the random key, converts the generated optical hash to a digital optical hash, and uploads the digital optical hash to the authentication server. When the authentication server receives the upload, it verifies whether the time of the upload is within a certain threshold time from the sending of the random key and whether the digital optical hash was generated from the same light as the plenoptic data. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332415 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/10 (20130101) G06F 2221/0733 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Image Data Processing or Generation, in General G06T 7/0002 (20130101) G06T 2207/10052 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0643 (20130101) H04L 9/0819 (20130101) H04L 9/0877 (20130101) H04L 9/0894 (20130101) H04L 9/3236 (20130101) Original (OR) Class H04L 9/3247 (20130101) H04L 9/3297 (20130101) H04L 2209/38 (20130101) Pictorial Communication, e.g Television H04N 5/22541 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210289633 | Hatch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Jonathan Douglas Hatch (Cleveland, Missouri); Stephen McGarry Hatch (Blue Springs, Missouri) |
| ABSTRACT | A system for providing selective adhesion printed circuit board (PCB) production comprises a conveyor mechanism, a curing system, and a computer. The conveyor mechanism is configured to convey a series of selective adhesion blanks, wherein each selective adhesion blank is utilized to produce a PCB and includes a flexible film, a substrate, a conductive layer, and a curable adhesive. The conductive layer is formed from electrically conductive material and adhered to the substrate. The curable adhesive is positioned between the flexible film and the conductive layer and is configured to selectively bond with the conductive layer when the curable adhesive is cured. The curing system is configured to cure the curable adhesive. The computer includes a processing element configured or programmed to: receive a plurality of PCB designs, and direct the curing system to cure the curable adhesive of a plurality of selective adhesion blanks for each PCB design. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/816607 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 3/0005 (20130101) H05K 3/108 (20130101) H05K 3/386 (20130101) H05K 3/1283 (20130101) Original (OR) Class H05K 3/4691 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
20210283270 — COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF THERAPEUTIC AND/OR DIAGNOSTIC AGENTS
| US 20210283270 | YANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian YANG (State College, Pennsylvania); Cheng DONG (State College, Pennsylvania); Zhiwei XIE (State College, Pennsylvania) |
| ABSTRACT | In one aspect, methods of targeted nanoparticle and cell delivery are described herein. In some embodiments, methods described herein comprise coupling nanoparticles and cells to a carrier cell to form a nanoparticle-cell conjugate or cell-cell conjugate, disposing the nanoparticle-cell or cell-cell conjugate in a biological environment, and delivering the nanoparticles and cells to target cells or tissues located within the biological environment. The nanoparticles comprise a biodegradable photoluminescent polymer, and the nanoparticle-cell conjugate is formed using one or more click chemistry reaction products. |
| FILED | Monday, January 06, 2020 |
| APPL NO | 16/734816 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) A61K 31/337 (20130101) A61K 31/437 (20130101) A61K 47/62 (20170801) A61K 47/65 (20170801) A61K 47/593 (20170801) A61K 47/6901 (20170801) Original (OR) Class A61K 47/6937 (20170801) A61K 49/0093 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283273 | CAMPOS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis M. CAMPOS (New York, New York); Tristan Hayes LAMBERT (Monroe, New York); Jessica L. FREYER (New York, New York); Spencer C. BRUCKS (Brooklyn, New York) |
| ABSTRACT | Non-viral gene delivery agents can be provided comprising a polyamine comprising a polymer containing a secondary amine, wherein the polyamine and a derivative of a cyclopropenium ion that are covalently attached. The non-viral gene delivery agents can be formed by a click reaction combining a polyamine polymer precursor backbone with a trisaminocyclopropenium polymer. The non-viral gene delivery agents can be used to deliver genetic material to cells in mammals or other organisms as part of gene therapy. |
| FILED | Friday, August 18, 2017 |
| APPL NO | 16/326606 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/58 (20170801) A61K 47/59 (20170801) A61K 47/541 (20170801) A61K 48/0041 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/32 (20130101) C08F 12/26 (20130101) C08F 293/005 (20130101) C08F 2438/01 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/0206 (20130101) C08G 81/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284303 | OUYANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (Boca Raton, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bing OUYANG (Fort Pierce, Florida); Tsung-Chow SU (Boca Raton, Florida); Yanjun LI (Fort Pierce, Florida); Jordan THOMAS (Boca Raton, Florida) |
| ABSTRACT | Underwater Deployable Structures (UDSs) capable of achieving inflation via mechanical pumps, moisture-activated expanding foams, water swelling material, or a hybrid of a mechanical pump and water swelling material. Moisture expanding foams begin as polyurethane-based resins of low viscosity, and react in the presence of water to become solid foam. In their final forms, the foams exist as open- or closed-cell, and vary in strength, elasticity, and rigidity. Water swelling material is also disclosed wherein the water swelling material is capable of achieving expansion numerous (e.g., up to about 250) times its initial volume when in contact with water and can shrink back to its initial volume upon dehydration, making the UDSs reusable. A mechanical pump may optionally be used to assist in initial inflation until the water swelling material reaches full expansion. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226913 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 11/52 (20130101) Original (OR) Class Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284980 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | James Jefferson Smith (Morrisville, North Carolina); Derek Jantz (Durham, North Carolina); Homme W. Hellinga (Durham, North Carolina) |
| ABSTRACT | Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/210219 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/902 (20130101) C12N 15/905 (20130101) C12N 15/907 (20130101) C12N 15/8213 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284981 | Doudna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Jillian F. Banfield (Berkeley, California); David Burstein (Berkeley, California); Steven C. Strutt (Berkeley, California); Lucas Benjamin Harrington (Berkeley, California) |
| ABSTRACT | The present disclosure provides CasX proteins, nucleic acids encoding the CasX proteins, and modified host cells comprising the CasX proteins and/or nucleic acids encoding same CasX proteins are useful in a variety of applications, which are provided. The present disclosure provides CasX guide RKAs that bind to and provide sequence specificity to the CasX proteins, nucleic acids encoding the CasX guide RNAs, and modified host cells comprising the CasX guide RNAs and/or nucleic acids encoding same. CasX guide RNAs are useful in a variety of applications, which are provided. The present disclosure provides archaeal Cas9 polypeptides and nucleic acids encoding same, as well as their associated archaeal Cas9 guide RNAs and nucleic acids encoding same. |
| FILED | Tuesday, July 23, 2019 |
| APPL NO | 17/258047 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0008 (20130101) Peptides C07K 2319/09 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210284995 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Dehua Zhao (Brookline, Massachusetts); Christopher A. Voigt (Belmont, Massachusetts); Michael Joseph Smanski (Falcon Heights, Minnesota) |
| ABSTRACT | The invention relates to methods and products for generating diverse libraries of genetic material. The products include libraries and constructed nucleic acids as well as kits and databases and systems thereof. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204219 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/66 (20130101) C12N 15/1034 (20130101) C12N 15/1058 (20130101) C12N 15/1093 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/06 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 20/30 (20190201) G16B 35/00 (20190201) G16B 35/10 (20190201) G16B 35/20 (20190201) G16B 50/00 (20190201) G16B 50/30 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/60 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285817 | Laforge et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | François Laforge (East Windsor, New Jersey); Herschel Rabitz (Lawrenceville, New Jersey); Howard Y. Bell (Princeton, New Jersey); Joshua E. Collins (Philadelphia, Pennsylvania) |
| ABSTRACT | Disclosed is a system and method for shaped incoherent light for control (SILC). More particularly, disclosed is a method for controlling the evolution of photo-responsive systems (including chemical species, biochemical species or material compounds) using a device capable of producing shaped incoherent light for such control. The disclosed device integrates a polychromatic incoherent source in an adaptive feedback control loop. |
| FILED | Friday, May 17, 2019 |
| APPL NO | 17/260303 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/10 (20130101) Original (OR) Class G01J 3/14 (20130101) G01J 3/42 (20130101) G01J 2003/423 (20130101) G01J 2003/1286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285828 | White et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Prasidiux, LLC (Arlington, Virginia) |
| ASSIGNEE(S) | Prasidiux, LLC (Arlington, Virginia) |
| INVENTOR(S) | Joseph C. White (Wakefield, Massachusetts); Bani H. Cipriano (Rockville, Maryland); Kevin K. Diehn (Towson, Maryland); Rel S. Ambrozy (Arlington, Virginia) |
| ABSTRACT | A stimulus indicating device is disclosed. The stimulus indicating device includes a stimulus sensitive amphiphilic gel; and an assembly having a first end and a second end. The assembly may include a top layer, a middle layer comprised of a porous polymer membrane, and a bottom layer. The top layer and the bottom layer may be sealed together on opposing sides of the assembly, and the top layer and the bottom layer may be sealed at the width of the second end of the assembly. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/329410 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285852 | Nelms |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| INVENTOR(S) | Brad Nelms (Brad, California) |
| ABSTRACT | Methods and compositions are provided for isolating protoplasts from plants and other multicellular, cell-wall containing organisms with high efficiency. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196681 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2405 (20130101) C12N 9/2437 (20130101) C12N 9/2442 (20130101) Enzymes C12Y 302/01004 (20130101) C12Y 302/01014 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 2001/305 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210286859 | EUBANK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Stephen EUBANK (Charlottesville, Virginia); Srini VENKATRAMANAN (Charlottesville, Virginia); Madhurima NATH (Charlottesville, Virginia); Yihui REN (Charlottesville, Virginia) |
| ABSTRACT | Embodiments disclose a system for determining a sensitivity of a networked system. The system identifies a vertex (V) that represents a constituent and a state of the constituent, and an interaction (E) between at least two Vs. An interaction-dependent function provides a probability that, when a perturbation occurs, a V will be in a certain state given that it is currently in a determined state and its neighbors are currently in determined states. A network reliability is used to determine a probability that a V's state holds when a perturbation occurs. The system evaluates only a certain amount of terms in a Taylor series from a sample, and identifies interpolating polynomials between the Taylor series. A cost function optimizes a property of the networked system for a fixed cost. The system perturbs the networked system until reliability is zero to estimate a sensitivity of the networked system. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185476 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/11 (20130101) Original (OR) Class G06F 17/17 (20130101) G06F 17/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210287392 | Warman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Cedar Warman (Corvallis, Oregon); John E. Fowler (Corvallis, Oregon) |
| ABSTRACT | A maize ear scanning device and computer vision kernel counting pipeline is used to analyze a maize ear. The process of analyzing the maize ear comprises: placing the ear on a rotating motor, fastened at the top with a metal pin on the sliding portion of the scanner; starting the motor's rotation; capturing an image of rotating ear with camera; converting rotating ear video into flat image by extracting individual frames, cropping to center horizontal pixel row, and concatenating all pixel rows; and running computer vision pipeline on image to identify seed locations. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/195446 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0004 (20130101) G06T 7/11 (20170101) G06T 7/70 (20170101) Original (OR) Class G06T 7/90 (20170101) G06T 11/00 (20130101) G06T 2207/10024 (20130101) G06T 2207/20132 (20130101) G06T 2207/30128 (20130101) G06T 2207/30242 (20130101) Pictorial Communication, e.g Television H04N 5/23232 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210287534 | Savla et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ketan Savla (Los Angeles, California); Pouyan Hosseini (Los Angeles, California) |
| ABSTRACT | The disclosure presents methods and apparatus for adaptive control of one or more traffic signals. A method may include determining an offset value based on a function of a traffic flow performance metric. The method may further include determining a green time split value based on a distributed algorithm. The method may further include adaptive control of the one or more traffic signals based on the green time split value and the offset value. |
| FILED | Friday, June 08, 2018 |
| APPL NO | 16/615104 |
| CURRENT CPC | Traffic Control Systems G08G 1/08 (20130101) G08G 1/082 (20130101) Original (OR) Class G08G 1/0116 (20130101) G08G 1/0133 (20130101) G08G 1/0145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210287949 | Moody et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Moody (Chicago, Illinois); Lincoln J. Lauhon (Chicago, Illinois); Ju Ying Shang (Romeoville, Illinois) |
| ABSTRACT | A system and method for performing in-situ measurements of semiconductor devices during chemical vapor deposition (CVD) includes disposing a chip carrier within a sealed chamber of a reactor for carrying out in-situ monitoring of partially fabricated semiconductor devices. The chip carrier includes a plurality of metallized bonding pads disposed along both peripheral edges on a same surface of the base for making electrical connections to metallized pads or contacts on the semiconductor device through bonding wires. Each of the plurality of metallized bonding pads disposed along both peripheral edges is electrically connected to each other as a pair through electrically connecting to a corresponding pair of ports which are disposed along both peripheral edges of the chip carrier. In-situ monitoring of the partially fabricated semiconductor device is performed through connecting the plurality of ports on the chip carrier to an external source-measure unit through a connector and wire harness. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197654 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/52 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2621 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/67253 (20130101) H01L 22/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288136 | Sensale-Rodriguez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Berardi Sensale-Rodriguez (Salt Lake City, Utah); Ashish Chanana (Salt Lake City, Utah); Steven M. Blair (Salt Lake City, Utah); Vikram Deshpande (Salt Lake City, Utah); Michael A. Scarpulla (Salt Lake City, Utah); Hugo Orlando Condori (Salt Lake City, Utah); Jeffrey Walling (Salt Lake City, Utah) |
| ABSTRACT | Ultra-compact inductor devices for use in integrated circuits (e.g., RF ICs) that use 3-dimensional Dirac materials for providing the inductor. Whereas inductors currently require significant real estate on an integrated circuit, because they require use of an electrically conductive winding around an insulative core, or such metal deposited in a spiral geometry, the present devices can be far more compact, occupying significantly less space on an integrated circuit. For example, an ultra-compact inductor that could be included in an integrated circuit may include a 3-dimensional Dirac material formed into a geometric shape capable of inductance (e.g., as simple as a stripe or series of stripes of such material), deposited on a substantially non-conductive (i.e., insulative) substrate, on which the Dirac material in the selected geometric shape is positioned. Low temperature manufacturing methods compatible with CMOS manufacturing are also provided. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/817077 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02118 (20130101) H01L 21/31058 (20130101) H01L 21/32055 (20130101) H01L 28/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288194 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhong Lin Wang (Atlanta, Georgia); Haiyang Zou (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides an alternating current (AC) generator comprising a substrate comprising a first material abutting a second material and forming an interface, wherein the first material comprises a first electrode and the second material comprises a second electrode in electrical communication with the first electrode, and wherein the substrate is configured to generate AC when the interface is exposed to periodic light stimulation. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/203417 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/02008 (20130101) H01L 31/02021 (20130101) H01L 31/022425 (20130101) Original (OR) Class Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288315 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Yingchao Yu (Ithaca, New York); Weidong Zhou (Ithaca, New York); Hao Chen (Ithaca, New York); Hector D. Abruna (Ithaca, New York) |
| ABSTRACT | A nanoparticle and a method for fabricating the nanoparticle utilize a decomposable material yoke located within permeable organic polymer material shell and separated from the permeable organic polymer material shell by a void space. When the decomposable material yoke comprises a sulfur material and the permeable organic polymer material shell comprises a material permeable to both a sulfur material vapor and a lithium ion within a battery electrolyte the nanoparticle may be used within an electrode for a Li/S battery absent the negative effects of battery electrode materials expansion. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197673 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/0404 (20130101) H01M 4/602 (20130101) H01M 4/1395 (20130101) H01M 4/1397 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210283234 | HASSAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HOSNI M. HASSAN (Raleigh, North Carolina); STEPHEN BRYAN TROXELL (Raleigh, North Carolina) |
| ABSTRACT | Provided herein are engineered Salmonella enterica serovar Typhimurium strains and compositions, including vaccines, thereof. Also provided herein are methods of treating and/or preventing infection by at least Salmonella enterica serovar Typhimurium in a subject in need thereof by administering a vaccine provided herein. |
| FILED | Friday, July 28, 2017 |
| APPL NO | 16/321795 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0275 (20130101) Original (OR) Class A61K 2039/55588 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210283235 — FOOD SAFETY VACCINE TO CONTROL SALMONELLA ENTERICA AND REDUCE CAMPYLOBACTER IN POULTRY
| US 20210283235 | Curtiss, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roy Curtiss, III (Gainesville, Florida); Soo-Young Wanda (Gainesville, Florida) |
| ABSTRACT | Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/207948 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/105 (20130101) A61K 39/205 (20130101) A61K 39/0275 (20130101) Original (OR) Class A61K 2039/522 (20130101) Peptides C07K 14/205 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/36 (20130101) C12N 15/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285023 | QUINONES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BEATRIZ QUINONES (SAN PABLO, California); BERTRAM G. LEE (SAN FRANCISCO, California); JASZEMYN C. YAMBAO (FAIRFIELD, California) |
| ABSTRACT | Provided are compositions, kits, and methods for the accurate detection of Listeria. In certain aspects and embodiments, the compositions, kits, and methods may provide improvements in relation to specificity, sensitivity, and speed of detection. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 16/815323 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Original (OR) Class C12Q 1/686 (20130101) C12Q 1/6853 (20130101) C12Q 2561/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210282986 | Goldish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); REGENTS OF THE UNIVERSITY OF MINNESOTA (Saint Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary Goldish (Plymouth, Minnesota); Andrew Hansen (Apple Valley, Minnesota); Gregory Voss (Apple Valley, Minnesota); Saeed Hashemi (Minneapolis, Minnesota); William K. Durfee (Minneapolis, Minnesota) |
| ABSTRACT | A wheelchair can comprise a frame and a plurality of wheels rotatably attached to the frame, and a motor coupled to the frame. A power source can be configured to power the motor. A drive shaft can be coupled to the motor. A first sprocket can be coupled to the drive shaft. A second sprocket can be configured to be rotationally fixed to a wheel of the plurality of wheels. A drive belt or chain can extend between the first sprocket and the second sprocket. An input device can be configured to receive an input from an operator and, in response to receiving the input, cause the motor to rotate. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200339 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/041 (20130101) Original (OR) Class A61G 5/048 (20161101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210283952 | Cooper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rory Cooper (Pittsburgh, Pennsylvania); JONATHAN DUVALL (Pittsburgh, Pennsylvania); ROBERT McDONOUGH (Grove City, Pennsylvania); AARON TYLER ANDERSON (Philadelphia, Pennsylvania); SIEW SEANG ONG (Singapore, Singapore); JEFFREY RUFFING (Pittsburgh, Pennsylvania) |
| ABSTRACT | A wheelchair can comprise: a frame comprising an upper portion and a lower portion that is coupled to the upper portion so that the upper portion is vertically adjustable with respect to the lower portion. A pair of drive wheels can be coupled to the frame. A plurality (e.g., a pair) of casters are coupled to the frame. Each caster can have a respective swivel axis. At least one caster of the plurality of casters can be configured to be locked to prevent swiveling about its respective swivel axis and unlocked to enable swiveling about its respective swivel axis. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200324 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/10 (20130101) Vehicle Wheels; Castors; Axles for Wheels or Castors; Increasing Wheel Adhesion B60B 33/0039 (20130101) B60B 33/0049 (20130101) B60B 33/0068 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285050 | Klarin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derek Klarin (Boston, Massachusetts); Scott M. Damrauer (Philadelphia, Pennsylvania); Christopher J. O'Donnell (Boston, Massachusetts); Philip S. Tsao (Palo Alto, California); Sekar Kathiresan (Boston, Massachusetts); Daniel J. Rader (Philadelphia, Pennsylvania); Peter W.F. Wilson (Decatur, Georgia); Themistocles L. Assimes (Palo Alto, California) |
| ABSTRACT | Disclosed are chimeric antigen receptor (CAR) polypeptides comprising a T cell receptor (TCR) antigen binding domain, a transmembrane domain, and an intracellular signaling domain. Disclosed are methods of making a CART cell comprising obtaining a cell from a subject diagnosed with T cell lymphoma; determining the sequence of the TCR on the cell; and transducing a T cell with a vector comprising a nucleic acid sequence that encodes a CAR polypeptide, wherein the CAR polypeptide comprises a TCR antigen binding domain, a transmembrane domain, and an intracellular signaling domain, wherein the TCR antigen binding domain is specific to a subsequence of the sequence of the TCR on the cell identified in the step of determining the sequence of the TCR |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/258084 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) A61K 31/7088 (20130101) A61K 38/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210282961 | Maier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Reia, LLC (Lyme, New Hampshire) |
| ASSIGNEE(S) | Reia, LLC (Lyme, New Hampshire) |
| INVENTOR(S) | Kaitlin E. Maier (Darien, Connecticut); Meegan P. Daigler (Portland, Maine); Ariana M. Sopher (Somerville, Massachusetts) |
| ABSTRACT | A pessary providing various structures, parts, and components to enable the pessary to remain deployed in a supportive position so that it may reliably provide the desired supportive capabilities. A ridge structure prevents over-rotation of the supportive members. The pessary can be formed preferably by injection molding where the mold has at least one insert. The geometry of the pessary can enable the pessary to have the required stiffness, flexibility, hinged capability, and softness where needed to achieve a pessary that is superior to prior art pessaries. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331312 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 6/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210285959 | MESSMER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ABREOS BIOSCIENCES, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradley T. MESSMER (San Diego, California); Dina UZRI (San Diego, California); Jessie-Farah FECTEAU (San Diego, California) |
| ABSTRACT | Methods and assays for detecting natalizumab in a sample, natalizumab-peptide complexes in a sample, and point-of-care devices for detecting natalizumab in a sample are described herein. |
| FILED | Friday, August 11, 2017 |
| APPL NO | 16/324878 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 2333/70546 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210288471 | Deppe |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dennis Glenn Deppe (Oviedo, Florida) |
| ASSIGNEE(S) | Dennis Glenn Deppe (Oviedo, Florida) |
| INVENTOR(S) | Dennis Glenn Deppe (Oviedo, Florida) |
| ABSTRACT | A semiconductor vertical resonant cavity light source includes an upper and lower mirror that define a vertical resonant cavity. An active region is within the cavity for light generation between the upper and lower mirror. At least one cavity spacer region is between the active region and the upper mirror or lower mirror. The cavity includes an inner mode confinement region and an outer current blocking region. An index guide in the inner mode confinement region is between the cavity spacer region and the upper or lower mirror. The index guide and outer current blocking region each include a lower and upper epitaxial material layer thereon with an epitaxial interface region in between. At least a top surface of the lower material layer includes aluminum in the interface region throughout a full area of an active part of the vertical light source. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135934 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/183 (20130101) H01S 5/187 (20130101) H01S 5/1833 (20130101) H01S 5/2018 (20130101) H01S 5/2059 (20130101) H01S 5/2063 (20130101) H01S 5/2072 (20130101) H01S 5/2086 (20130101) H01S 5/18308 (20130101) H01S 5/18327 (20130101) H01S 5/18333 (20130101) Original (OR) Class H01S 5/18358 (20130101) H01S 5/18361 (20130101) H01S 5/18391 (20130101) H01S 2301/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20210286036 | Williams et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dylan Forrest Williams (Boulder, Colorado); Aric Warner Sanders (Broomfield, Colorado) |
| ABSTRACT | A calibration apparatus calibrates cross-frequency phases of large-signal network analyzer measurements and includes: a signal generator; a vector network analyzer that includes couplers and receivers that receive the calibration signal and the reference multitone signal from the signal generator; a calibration receiver that receives a calibration signal from the vector network analyzer and produces a digitized calibration temporal signal from the calibration signal; and a signal processor in communication with the signal generator and the vector network analyzer and that: receives the reference digitized signal from the reference receiver; receives the forward digitized signal from the forward coupled receiver; receives the reverse digitized signal from the reverse coupled receiver; receives the digitized calibration temporal signal from the calibration receiver; and produces a calibration factor from the reference digitized signal, the forward digitized signal, the reverse digitized signal, and the digitized calibration temporal signal. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193441 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 27/28 (20130101) G01R 35/007 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210287949 | Moody et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Moody (Chicago, Illinois); Lincoln J. Lauhon (Chicago, Illinois); Ju Ying Shang (Romeoville, Illinois) |
| ABSTRACT | A system and method for performing in-situ measurements of semiconductor devices during chemical vapor deposition (CVD) includes disposing a chip carrier within a sealed chamber of a reactor for carrying out in-situ monitoring of partially fabricated semiconductor devices. The chip carrier includes a plurality of metallized bonding pads disposed along both peripheral edges on a same surface of the base for making electrical connections to metallized pads or contacts on the semiconductor device through bonding wires. Each of the plurality of metallized bonding pads disposed along both peripheral edges is electrically connected to each other as a pair through electrically connecting to a corresponding pair of ports which are disposed along both peripheral edges of the chip carrier. In-situ monitoring of the partially fabricated semiconductor device is performed through connecting the plurality of ports on the chip carrier to an external source-measure unit through a connector and wire harness. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197654 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/52 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 31/2621 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/67253 (20130101) H01L 22/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20210288397 | Yurduseven et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Okan Yurduseven (Durham, North Carolina); Vinay Ramachandra Gowda (Durham, North Carolina); Jonah Gollub (Durham, North Carolina); David R. Smith (Durham, North Carolina) |
| ABSTRACT | Systems and methods are disclosed herein for printed cavities for computational microwave imaging and methods or use. According to an aspect, an imaging system includes a printed cavity having a layer having a first surface and a second surface. The printed cavity defines multiple apertures that extend between the first surface and the second surface. The printed cavity also includes a substrate being attached to the first surface of the layer. The substrate is also configured to be fed a guided wave that excites the apertures to produce a radiation pattern for illuminating a scene. The imaging system also include one or more antennas configured to generate a signal for imaging based on the illuminated scene. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/328383 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/887 (20130101) Antennas, i.e Radio Aerials H01Q 1/38 (20130101) Original (OR) Class H01Q 1/40 (20130101) H01Q 13/18 (20130101) H01Q 21/0012 (20130101) H01Q 21/0025 (20130101) H01Q 21/0031 (20130101) H01Q 21/064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210284352 | Papas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aurora Flight Sciences Corporation, a subsidiary of The Boeing Company (Manassas, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary Richard Papas (Manassas, Virginia); Neil Titchener (Manassas, Virginia); Brian M. Yutko (Manassas, Virginia); Clint Church (Manassas, Virginia); Jian Long Tian (Manassas, Virginia) |
| ABSTRACT | An aircraft with an integrated boundary layer ingesting propulsion having a mechanically-distributed propulsion system. The mechanically-distributed propulsion system may include an engine to generate a mechanical drive power, a drive shaft, a direction-reversing transmission, and a propulsor fan. The drive shaft may be operatively coupled to the engine to receive the mechanical drive power. The direction-reversing transmission may have a first rotating shaft and a second rotating shaft, the first rotating shaft operatively coupled to the drive shaft to receive the mechanical drive power, which is configured to redirect the mechanical drive power received at the first rotating shaft from a first direction to face a second direction at the second rotating shaft. The propulsor fan may be coupled to the second rotating shaft to convert the mechanical drive power into thrust. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332085 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 1/16 (20130101) B64C 21/00 (20130101) B64C 21/06 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/14 (20130101) B64D 33/04 (20130101) B64D 35/00 (20130101) Original (OR) Class Jet-propulsion Plants F02K 3/062 (20130101) Gearing F16H 1/222 (20130101) F16H 37/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Geospatial Intelligence Agency (NGA)
| US 20210287393 | Warnaar, PhD |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Applied Research Associates, Inc. (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dirk B. Warnaar, PhD (Raleigh, North Carolina) |
| ABSTRACT | Systems and techniques for determining a list of geographic location candidates from an image of an environment are described. Open source data indicative of the earth's surface may be obtained and combined into grids to create region data to gain a representation of the earth's surface within each grid cell. An image of an environment may be obtained from an unknown camera. Image characteristics may be compared to the region data to determine error between the image characteristics and projections of the region data. A list of lowest error geographic location candidates may be determined and provided to the user. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 16/818552 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/04 (20130101) Image Data Processing or Generation, in General G06T 7/73 (20170101) Original (OR) Class G06T 7/80 (20170101) G06T 2207/30244 (20130101) Pictorial Communication, e.g Television H04N 13/111 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20210288809 | Brostrom |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cyber Pack Ventures, Inc. (Columbia, Maryland) |
| ASSIGNEE(S) | Cyber Pack Ventures, Inc. (Columbia, Maryland) |
| INVENTOR(S) | Thomas Edward Brostrom (Ellicott City, Maryland) |
| ABSTRACT | Embodiments of the present invention are directed to an improved system and method of producing, recording and reporting boot integrity measurements of an Internet of Things (“IoT”) computing device to resource (such as an on-chip software module, an external software module, a printer, a network router, or a server), so the resource can confirm that the IoT computing device can be trusted before access to the resource is granted. Embodiments provide a new and less expensive architecture for reliably collecting and relaying device state information to support trust-sensitive applications. Embodiments leverage crypto-acceleration modules found on many existing microprocessors and microcontroller-based IoT devices, while introducing little additional overhead or additional circuitry. Embodiments provide a Root of Trust module comprising integrated internal control logic that functions as a secure on-chip wrapper for cryptographic primitive modules, which provide secure storage and reporting of the host's platform integrity measurements. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149166 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/002 (20130101) H04L 9/3234 (20130101) Original (OR) Class H04L 9/3236 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20210284889 | Frihart et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America as Represented by the (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles R. Frihart (Dane, Wisconsin); Linda F. Lorenz (Middleton, Wisconsin) |
| ABSTRACT | Methods of making and using adhesive compositions based on oilseed solids are provided. Also provided are adhesive compositions made using the methods. The adhesive compositions are made by mixing defatted oilseed solids with a polyisocyanate to form a non-aqueous adhesive composition and, subsequently, mixing the non-aqueous adhesive composition with water to form an aqueous adhesive composition. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197956 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/10 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 189/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, September 16, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page