FedInvent™ Patent Applications

Application Details for Thursday, October 07, 2021 

This page was updated on Friday, October 08, 2021 at 04:17 PM GMT

Department of Health and Human Services (HHS) 

US 20210307688 Lansdorp et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S) Milo Sensors, Inc. (Santa Barbara, California)
ASSIGNEE(S)
INVENTOR(S) Bob M. Lansdorp (Santa Barbara, California);  Peter Lamberg (Santa Barbara, California)
ABSTRACT A means of detecting skin proximity of a wearable comprising: at least two skin proximity sensors, a controller and a transmitter. The proximity sensors can be arranged around a central biosensor to detect tamper attempts. The sensors can be strapped to a person's skin by means of a strap and further sealed on the skin by means of a bioadhesive. Signals from the proximity sensor can be processed by the controller and a ratio baseline obtained. Any appreciable deviations from unity will indicate a tampering event, such as device removal, sensor blockage or sabotage. Results of proximity sensing can be reported to the wearer by means of a monthly calendar, or a daily calendar view in a wearable device.
FILED Thursday, April 01, 2021
APPL NO 17/301395
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0022 (20130101)
A61B 5/681 (20130101) Original (OR) Class
A61B 5/4845 (20130101)
A61B 5/6831 (20130101)
A61B 5/6832 (20130101)
A61B 5/7246 (20130101)
A61B 2562/0257 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307707 Stayman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Joseph Webster Stayman (Baltimore, Maryland);  Steven Tilley (Baltimore, Maryland)
ABSTRACT The present invention is directed to spatial-spectral filtering for multi-material CT decomposition. The invention includes a specialized filter that spectrally shapes an x-ray beam into a number of beamlets with different spectra. The filter allows decomposition of an object/anatomy into different material categories (including different biological types: muscle, fat, etc. or exogenous contrast agents that have been introduced: e.g iodine, gadolinium, etc.). The x-ray beam is spectrally modulated across the face of the detector using a repeating pattern of filter materials. Such spatial-spectral filters allow for collection of many different spectral channels using “source-side” control. However, in contrast to other spectral techniques that provide mathematically complete projection data, spatial-spectral filtered data is sparse in each spectral channel—making traditional projection-domain or image-domain material decomposition difficult to apply. Therefore, the present invention uses model-based material decomposition, which combines reconstruction and multi-material decomposition, and permits arbitrary spectral, spatial, and angular sampling patterns.
FILED Friday, October 25, 2019
APPL NO 17/288839
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 6/032 (20130101)
A61B 6/4042 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307712 Speidel et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Michael Speidel (Madison, Wisconsin);  Erick Oberstar (Verona, Wisconsin);  Martin Wagner (Madison, Wisconsin);  Maria Pravdivtseva (Lubeck, Germany)
ABSTRACT A system and method is provided for imaging a contrast agent. The system includes a power injector that delivers a contrast agent as a series of boluses using a known period, flow rate, or duration and with a rate of at least one or more separate boluses per cardiac cycle. An x-ray imaging system acquires a reference dataset of the subject before the contrast agent is delivered and acquires an imaging dataset as the series of boluses are delivered to the subject, wherein multiple images are acquired of the subject per bolus. A computer system receives the reference dataset and the imaging dataset from the x-ray imaging system and reconstructs the reference dataset and the imaging dataset using a reconstruction process that removes the subject from the images to generate time-resolved volumetric images of the contrast agent moving within a volume of the subject without the subject.
FILED Wednesday, April 01, 2020
APPL NO 16/837801
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 6/504 (20130101) Original (OR) Class

Image Data Processing or Generation, in General
G06T 5/50 (20130101)
G06T 7/20 (20130101)
G06T 2207/10081 (20130101)
G06T 2207/20224 (20130101)
G06T 2207/30101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307817 HENDON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S)
INVENTOR(S) CHRISTINE HENDON (Bronx, New York);  RAJINDER SINGH-MOON (Mastic, New York);  XIN YU (Guangdong, China PRC)
ABSTRACT An exemplary system, method and computer-accessible medium for determining particular for a portion(s) of an organ of a patient(s) can be provided, which can include, for example, receiving an in vivo optical coherence tomography (OCT) imaging information for the portion(s), and determining (i) a lesion formation on or in the portion(s), (ii) a contact of a catheter on or with the portion(s), or (iii) an angle of the catheter with respect to the portion(s), by applying a convolutional neural network(s) to the in vivo OCT imaging information.
FILED Monday, March 29, 2021
APPL NO 17/215568
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 18/1492 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/0454 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 2207/10101 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30096 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307963 Smith et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) iRenix Medical, Inc. (Palo Alto, California)
ASSIGNEE(S)
INVENTOR(S) Stephen J. Smith (Palo Alto, California);  Thomas W. Chalberg, Jr. (Palo Alto, California);  Espir Gabriel Kahatt (Palo Alto, California);  Greg Yedinak (Palo Alto, California)
ABSTRACT Therapeutic agent delivery devices are provided. Aspects of the devices include an active agent composition and an actuator configured to deliver the active agent composition to a target delivery site. In some instances, aspects of the devices include a syringe comprising a viscous active agent composition, a needle operably coupled to the syringe and an actuator configured to deliver viscous active agent composition from the syringe through the needed to a target delivery site, such as an intravitreal site. In some instances, aspects of the devices include a sleeve comprising a solid formulation of the active agent; a needle operably coupled to the sleeve; and an actuator configured to move the solid formulation from the sleeve and through the needle, e.g., to an intravitreal location. In some instances, aspects of the devices include a syringe containing a composition for subcutaneous delivery, a needle operably coupled to the syringe, a motorized actuator configured to deliver the composition from the syringe through the needle to a target subcutaneous site, and a pain mitigation system. Also provided are methods of using the devices.
FILED Wednesday, August 21, 2019
APPL NO 17/269348
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 9/0008 (20130101) Original (OR) Class

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/20 (20130101)
A61M 5/32 (20130101)
A61M 5/31533 (20130101)
A61M 2005/3125 (20130101)
A61M 2202/048 (20130101)
A61M 2210/0612 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308064 KONG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S) Hyunjoon KONG (Champaign, Illinois);  Yu-Tong HONG (Urbana, Illinois);  Yongbeom SEO (Woodbury, Minnesota)
ABSTRACT Provided herein are stimulus-responsive polymer microgelator particles that can activate fibrin fiber formation from their surfaces by actively ejecting thrombin to form an interconnected fibrin network with an increased elastic modulus and desirable microstructure. The use of the microgelators enables the decoupling of gelation rate and gel rigidity.
FILED Friday, April 02, 2021
APPL NO 17/221203
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101)
A61K 9/5031 (20130101) Original (OR) Class
A61K 38/363 (20130101)
A61K 38/4833 (20130101)
A61K 47/02 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 7/04 (20180101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 23/34 (20130101)
B01J 31/06 (20130101)
B01J 35/026 (20130101)
B01J 37/0072 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308065 Scott et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Allergy and Infectious Diseases (NIAID)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Evan A. Scott (Northfield, Illinois);  Sharan Bobbala (Evanston, Illinois);  Sean D. Allen (Evanston, Illinois)
ABSTRACT Provided herein are bicontinuous nanosphere nanocarrier that allow for slow, sustained release or allow for targeted release of target molecules. Further embodiments of the present invention provide bicontinuous nanosphere nanocarrier comprising a photosensitizer and a suitable polymer. Also provided are methods for making and using the photosensitive nanocarrier.
FILED Monday, April 05, 2021
APPL NO 17/301512
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/51 (20130101)
A61K 9/5031 (20130101) Original (OR) Class
A61K 31/20 (20130101)
A61K 31/4745 (20130101)
A61K 38/385 (20130101)
A61K 41/0071 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308077 Scherzer
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Clemens Scherzer (Boston, Massachusetts)
ABSTRACT Provided herein are methods of treating a subject who has a synucleinopathy (e.g., Parkinson's disease) that include: administering to a subject in need of such treatment therapeutically effective amounts of a β2-adrenoreceptor agonist and at least one therapeutic agent selected from the group consisting of: a synucleinopathy therapeutic agent, a β2-adrenoreceptor antagonist and a health supplement, wherein the health supplement is selected from the group consisting of caffeine, inosine, creatine, coenzyme Q10, vitamin E, and omega-3 fatty acids, to thereby treat Parkinson's disease in the subject.
FILED Friday, April 20, 2018
APPL NO 16/606534
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/136 (20130101) Original (OR) Class
A61K 31/137 (20130101)
A61K 31/138 (20130101)
A61K 31/166 (20130101)
A61K 31/198 (20130101)
A61K 31/403 (20130101)
A61K 31/428 (20130101)
A61K 31/4045 (20130101)
A61K 31/4704 (20130101)
A61K 31/5377 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308087 Van Dyke
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) Forsyth Dental Infirmary for Children (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Thomas E. Van Dyke (West Roxbury, Massachusetts)
ABSTRACT The invention provides new methods for inducing or promoting bone growth and/or for reducing or preventing bone deterioration in a mammal subject. The inventive methods generally comprise administering to the subject an effective amount of a resolving. In particular, the inventive methods may be useful for treating or preventing conditions associated with bone degradation, deterioration or degeneration such as periodontal disease, osteoarthritis, and metastatic bone disease and osteolytic bone disease. Pharmaceutical compositions and kits comprising at least one resolving are also provided that can be used to performed the inventive methods.
FILED Friday, November 13, 2020
APPL NO 17/097465
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/22 (20130101)
A61K 31/202 (20130101) Original (OR) Class
A61K 31/557 (20130101)
A61K 31/663 (20130101)
A61K 45/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308107 HAASS-KOFFLER
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S) Brown University (Providence, Rhode Island)
ASSIGNEE(S)
INVENTOR(S) Carolina L. HAASS-KOFFLER (Providence, Rhode Island)
ABSTRACT Stress responses involve corticotropin releasing factor (CRF), the two cognate receptors (CRF1 and CRF2) and the CRF-binding protein (CRFBP). Utilizing a novel cell-based assay, a C-terminal CRFBP fragment [CRFBP(10 kD)] was found to potentiates CRF-intracellular Ca2+ release, demonstrating that CRFBP possesses excitatory roles in addition to the inhibitory role established by the N-terminal fragment of CRFBP [CRFBP(27 kD)]. This interaction was CRF2-specific, as CRF1 responses were not potentiated by CRFBP(10 kD). As there were currently no small molecule ligands available that selectively interact with either CRFBP or CRF2, a cell-based assay was miniaturized, wherein CRFBP(10 kD) was fused as a chimera with CRF, that allowed us to a perform a high-throughput screen (HTS) of approximately 350,000 small molecules. This resulted in the identification of negative allosteric modulators (NAMs) of the CRFBP(10 kD)-CRF2 complex that blunt CRF-induced potentiation of N-Methyl-D-aspartic acid receptor (NMDAR)-mediated synaptic transmission in dopamine neurons in the ventral tegmental area (VTA). These results provide the first evidence of specific roles for CRF2 and CRFBP in the modulation of neuronal activity and suggest that NMDARs in the VTA may be a target for the treatment of stress and substance abuse disorders such as alcohol use disorder.
FILED Wednesday, September 04, 2019
APPL NO 17/273607
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/517 (20130101)
A61K 31/4245 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308128 Mohsen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Al-Walid A. Mohsen (Gibsonia, Pennsylvania);  Gerard Vockley (Pittsburgh, Pennsylvania)
ABSTRACT Methods of treating mitochondrial fatty acid β-oxidation and/or transport disorders arising from mutant proteins in the mitochondrial fatty acid β-oxidation and transport metabolic pathways in patients are provided. The methods modulate the mitochondrial fatty acid β-oxidation pathway at the last step so that the product of the mutant protein accumulates and stabilizes the mutant protein and/or the substrate(s)/product(s) of the down stream reactions accumulate and possibly bind to allosteric sites on the mutant protein to stabilize it. Trimetazidine pharmacodynamics function as such in the β-oxidation pathway. Further, a synergistic effect is observed where trimetazidine and PPARδ agonist combination enhanced enzyme activity and presence significantly more than either alone.
FILED Thursday, June 10, 2021
APPL NO 17/344084
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/426 (20130101)
A61K 31/495 (20130101)
A61K 31/496 (20130101) Original (OR) Class
A61K 38/45 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/08 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308131 SCANGARELLA-OMAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
Assistant Secretary for Preparedness and Response (ASPR)
Biomedical Advanced Research and Development Authority (BARDA)
APPLICANT(S) GlaxoSmithKline Intellectual Property Development Limited (Brentford, United Kingdom)
ASSIGNEE(S)
INVENTOR(S) Nicole SCANGARELLA-OMAN (Collegeville, Pennsylvania);  Etienne F. Dumont (Collegeville, Pennsylvania);  Aline Bergesch Barth (Collegeville, Pennsylvania)
ABSTRACT The present invention relates to a novel treatment method for the treatment of an infection caused by Neisseria gonorrhoeae, comprising administering gepotidacin or a pharmaceutically acceptable salt thereof to a human in need thereof, in accordance with a treatment regimen as defined herein.
FILED Thursday, April 01, 2021
APPL NO 17/219940
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0053 (20130101)
A61K 31/4985 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308133 LI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Yi-Ping LI (Houston, Texas);  Guohua ZHANG (Houston, Texas)
ABSTRACT Method of reducing or preventing muscle loss, such as from cancer-induced cachexia, p38β MAPK inhibitors are provided. Compositions for use in such methods are also provided.
FILED Tuesday, April 06, 2021
APPL NO 17/223507
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/506 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/06 (20180101)
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308134 Hata et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) BLUEPRINT MEDICINES CORPORATION (Cambridge, Massachusetts);  The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Aaron Hata (Boston, Massachusetts);  Lecia Sequist (Boston, Massachusetts);  Beni B. Wolf (Cambridge, Massachusetts)
ABSTRACT Disclosed herein are methods for treating an EGFR-mutant cancer in a patient in need thereof by administering to the patient a therapeutically effective amount of at least one RET inhibitor (e.g., Compound 1 and/or pharmaceutically acceptable salts thereof) and a therapeutically effective amount of at least one EGFR inhibitor (e.g., osimertinib and/or pharmaceutically acceptable salts thereof), as well as combination therapies including at least one RET inhibitor and at least one EGFR inhibitor.
FILED Friday, August 09, 2019
APPL NO 17/267149
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0056 (20130101)
A61K 31/47 (20130101)
A61K 31/506 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308149 Covey et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Washington University (St. Louis, Missouri);  Sage Therapeutics, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Douglas Covey (St. Louis, Missouri);  Albert Jean Robichaud (Ringoes, New Jersey)
ABSTRACT The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
FILED Monday, June 21, 2021
APPL NO 17/304433
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/56 (20130101)
A61K 31/58 (20130101) Original (OR) Class
A61K 31/565 (20130101)
A61K 31/566 (20130101)
A61K 31/573 (20130101)

Steroids
C07J 1/0011 (20130101)
C07J 1/0018 (20130101)
C07J 1/0029 (20130101)
C07J 5/0015 (20130101)
C07J 7/002 (20130101)
C07J 9/005 (20130101)
C07J 13/007 (20130101)
C07J 21/00 (20130101)
C07J 21/006 (20130101)
C07J 21/008 (20130101)
C07J 41/0005 (20130101)
C07J 41/0094 (20130101)
C07J 51/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308168 PAINTER et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) EMORY UNIVERSITY (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) George R. PAINTER (Atlanta, Georgia);  David PERRYMAN (Decatur, Georgia);  Gregory R. BLUEMLING (Decatur, Georgia)
ABSTRACT Disclosed are halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections. Such viral infections can include tongaviridae, bunyaviridae, arenaviridae, coronaviridae, flaviviridae, picornaviridae, Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infections.
FILED Thursday, March 07, 2019
APPL NO 16/979108
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/008 (20130101)
A61K 31/7068 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308171 BERNSTEIN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts);  THE GENERAL HOSPITAL CORPORATION (BOSTON, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Bradley E. BERNSTEIN (Boston, Massachusetts);  John G. DOENCH (Cambridge, Massachusetts);  Fadi J. NAJM (Boston, Massachusetts)
ABSTRACT CRISPR-Cas9 has enabled a new generation of screening strategies to interrogate gene function. However, redundant genes and the complexity of functional gene networks can confound single gene knockout approaches. Furthermore, simple addition of two or more sgRNAs has shown only modest targeting efficacy in screening approaches. The present invention relates to combined orthogonal CRISPR-derived components to maximize gene targeting activity with minimal cross-talk and interference. The present invention also relates to efficient S. aureus Cas9 sgRNA design rules, which were paired with S. pyogenes Cas9 sgRNA design rules to achieve dual target gene inactivation in a high fraction of cells. Applicants developed a lentiviral vector and cloning strategy to generate high complexity pooled dual-knockout libraries and show that screening these libraries can identify combinatorial phenotypes, including synthetic lethal gene pairs across multiple cell types. The gene pairs can be targeted therapeutically and Applicants disclose therapeutically effective combination therapies.
FILED Wednesday, August 07, 2019
APPL NO 17/266538
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101) Original (OR) Class
A61K 35/17 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/02 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/111 (20130101)

Combinatorial Chemistry; Libraries, e.g Chemical Libraries
C40B 30/06 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5023 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308195 Danino et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Tal Danino (New York, New York);  Nicholas Arpaia (New York, New York);  Sreyan Chowdhury (New York, New York);  Candice Gurbatri (New York, New York)
ABSTRACT Disclosed herein are programmable bacteria for tumor-targeted immunotherapeutic delivery. In certain embodiments, the programmable bacteria comprise at least one synchronized lysis circuit contained in a single operon which are capable of being further engineered to cyclically produce anti-cancer therapeutic agents including but not limited to nanobodies against immune checkpoint inhibitors and over-expressed markers in cancers, toxins, tumor antigens, cytokines, and chemokines. In some embodiments, the programmable bacteria comprise at least one synchronized lysis circuit contained in a single operon and at least one plasmid producing a therapeutic agent, i.e., at least one plasmid comprising a nucleic acid sequence which encodes a therapeutic agent. The disclosure also provides methods of curing and treating cancer using the programmable bacteria.
FILED Wednesday, January 20, 2021
APPL NO 17/152893
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/74 (20130101) Original (OR) Class
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/195 (20130101)
C07K 14/521 (20130101)
C07K 16/2803 (20130101)
C07K 16/2818 (20130101)
C07K 16/2827 (20130101)
C07K 16/2896 (20130101)
C07K 2317/569 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308212 DAGGETT et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Valerie DAGGETT (Seattle, Washington);  Alissa BLEEM (Seattle, Washington)
ABSTRACT Disclosed herein are α-sheet peptides and their use for treating a bacterial infection and/or limiting bacterial biofilm formation.
FILED Friday, May 21, 2021
APPL NO 17/326561
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/70 (20130101)
A61K 38/02 (20130101)
A61K 38/16 (20130101) Original (OR) Class

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/22 (20130101)
A61L 27/34 (20130101)
A61L 27/54 (20130101)
A61L 29/16 (20130101)
A61L 29/085 (20130101)
A61L 31/10 (20130101)
A61L 31/16 (20130101)
A61L 2202/24 (20130101)
A61L 2300/25 (20130101)
A61L 2300/252 (20130101)
A61L 2300/404 (20130101)
A61L 2300/606 (20130101)
A61L 2420/02 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)
A61P 41/00 (20180101)

Peptides
C07K 16/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308233 Avci et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia)
ASSIGNEE(S)
INVENTOR(S) Fikri Y. Avci (Watkinsville, Georgia);  Dustin Middleton (Athens, Georgia);  Amy Victoria Paschall (Washington, Georgia)
ABSTRACT Provided herein is a protein, referred to as a Pn3Pase protein, that degrades the capsular polysaccharide of serotype 3 Streptococcus pneumoniae. The disclosure includes a genetically modified cell that includes a Pn3Pase protein, and compositions that include the protein, the polynucleotide encoding the protein, the genetically modified cell, or a combination thereof. Also provided are methods for using a Pn3Pase protein, including methods for contacting a S. pneumoniae having a type III capsular polysaccharide with a Pn3Pase protein, increasing deposition of at least one complement component on the surface of a S. pneumoniae, treating an infection in a subject, treating a symptom in a subject, decreasing colonization of a subject by S. pneumoniae, or a combination thereof.
FILED Monday, August 13, 2018
APPL NO 16/636503
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/47 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
C12N 9/2402 (20130101)
C12N 2510/00 (20130101)

Enzymes
C12Y 302/01031 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308242 ZURAWSKI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Science Foundation (NSF)
APPLICANT(S) BAYLOR RESEARCH INSTITUTE (Dallas, Texas)
ASSIGNEE(S) BAYLOR RESEARCH INSTITUTE (Dallas, Texas)
INVENTOR(S) Gerard ZURAWSKI (Midlothian, Texas);  Jacques F. Banchereau (Montclair, New Jersey);  Anne-Laure FLAMAR (New York, New York);  Peter KLUCAR (Magnolia, Arkansas);  Keiko AKAGAWA (Dallas, Texas);  Sandra ZURAWSKI (Midlothian, Texas);  SangKon OH (Baltimore, Maryland)
ABSTRACT The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
FILED Monday, April 12, 2021
APPL NO 17/301704
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/001129 (20180801) Original (OR) Class
A61K 2039/6056 (20130101)

Peptides
C07K 14/435 (20130101)
C07K 16/2878 (20130101)
C07K 2319/00 (20130101)
C07K 2319/33 (20130101)
C07K 2319/91 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308244 MURPHY et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) UNIVERSITY OF WASHINGTON (SEATTLE, Washington)
ASSIGNEE(S)
INVENTOR(S) Sean C. MURPHY (Seattle, Washington);  Brad STONE (Seattle, Washington)
ABSTRACT An immunogenic composition is provided herein. The immunogenic compositions are used to identify and select immunogenic antigens that elicit immune responses in a subject and may be subsequently used in multi-antigen vaccine compositions against one or more diseases or conditions. According to some embodiments, the immunogenic composition may include a plurality of nucleic acid fragments or minigenes derived from a nucleic acid library, wherein each nucleic acid fragment encodes a different antigen or functional portion thereof, and wherein the different antigens or functional portions thereof are associated with one or more disease or condition. The immunogenic composition may also include a delivery medium loaded with the plurality of nucleic acid fragments and in some embodiments, the delivery medium is loaded with nucleic acid fragments in such a way that individual antigen presenting cells receive only a subset of the nucleic acids within a vaccine in order to minimize antigenic competition.
FILED Tuesday, February 02, 2021
APPL NO 17/165867
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/015 (20130101) Original (OR) Class
A61K 45/06 (20130101)
A61K 47/6921 (20170801)
A61K 2039/5154 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 33/06 (20180101)

Peptides
C07K 14/15 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308247 Granoff et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Children's Hospital and Research Center at Oakland (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Dan M. Granoff (San Francisco, California);  Victor Chen-Hsi Hou (Bethlehem, Pennsylvania)
ABSTRACT The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis serogroup B strain.
FILED Friday, October 30, 2020
APPL NO 17/085924
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/127 (20130101)
A61K 39/095 (20130101) Original (OR) Class
A61K 2039/522 (20130101)

Peptides
C07K 14/22 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308250 Du et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Non-Profit Organization (NPO)
New York Blood Center (NYBC)
APPLICANT(S) New York Blood Center, Inc. (New York, New York);  Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Lanying Du (Rego Park, New York);  Wanbo Tai (Elmhurst, New York);  Fang Li (St. Paul, Minnesota)
ABSTRACT Provided herein are methods of use of subunit immunogenic compositions, in particular for the prevention and treatment of Zika vims infections.
FILED Friday, October 25, 2019
APPL NO 17/287938
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101) Original (OR) Class
A61K 39/39 (20130101)
A61K 2039/55 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308254 Jiang et al.
FUNDED BY
Department of Health and Human Services (HHS)
Centers for Disease Control and Prevention (CDC)
APPLICANT(S) THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
ASSIGNEE(S) TED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Massachusetts)
INVENTOR(S) Baoming Jiang (Duluth, Georgia);  Roger I. Glass (Atlanta, Georgia);  Yuhuan Wang (Liburn, Georgia);  Jon Gentsch (Atlanta, Georgia)
ABSTRACT A vaccine composition and method of vaccination are provided useful for immunizing a subject against a rotavirus. The vaccines include rotavirus strains CDC-9 and CDC-66, fragments thereof, homologues thereof, or combinations thereof. Inventive vaccines may include a fragment of CDC-9, CDC-66, homologues thereof, or combinations thereof. Methods of inducing an immunological response are provided by administering an inventive vaccine.
FILED Wednesday, June 16, 2021
APPL NO 17/349639
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/15 (20130101) Original (OR) Class
A61K 2039/5252 (20130101)

Peptides
C07K 14/005 (20130101)
C07K 16/10 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308256 Stamatatos et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington)
ASSIGNEE(S) FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington)
INVENTOR(S) Leonidas Stamatatos (Seattle, Washington);  Andrew McGuire (Seattle, Washington);  Katherine Rachael Parks (Seattle, Washington)
ABSTRACT Sequential immunization strategies to guide the maturation of antibodies against the human immunodeficiency virus (HIV) are described. The sequential immunization strategies utilize an HIV envelope protein (Env) that binds germline (gl) B cells as a first (prime) immunization and an Env with a functional glycosylated N276 as a second (boost) immunization. The sequential immunization strategies successfully elicit neutralizing antibodies against HIV.
FILED Thursday, August 29, 2019
APPL NO 17/269199
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/21 (20130101) Original (OR) Class
A61K 2039/545 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308286 Pomper et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland);  University Health Network (Toronto, Canada)
ASSIGNEE(S)
INVENTOR(S) Martin G. Pomper (Baltimore, Maryland);  Ronnie C. Mease (FAIRFAX, Virginia);  Ying Chen (Luhterville-Timonium, Maryland);  Sangeeta Ray (Ellicott City, Maryland);  Juan Chen (Toronto, Canada);  Marta Overchuk (TORONTO, Canada);  Kara Harmatys (Toronto, Canada);  Gang Zheng (Toronto, Canada)
ABSTRACT Theranostic probes comprising a porphyrin-based photosensitizer, a D-peptide linker, and a urea-based PSMA-targeting ligand and methods of their use for treating and/or imaging PMSA-expressing tumors are disclosed.
FILED Tuesday, July 30, 2019
APPL NO 17/264220
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 41/0071 (20130101)
A61K 41/0076 (20130101)
A61K 47/65 (20170801)
A61K 49/0036 (20130101)
A61K 49/0056 (20130101)
A61K 51/088 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308320 Davidson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Matthew Davidson (Philadelphia, Pennsylvania);  Jason Alan Burdick (Philadelphia, Pennsylvania)
ABSTRACT Provided is a multi-fiber system that undergoes new chemical bonds in response to mechanical manipulation and has self-adhesive properties based on specific chemical reactions.
FILED Monday, March 15, 2021
APPL NO 17/201446
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 24/08 (20130101) Original (OR) Class
A61L 24/0015 (20130101)

Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives
C09J 9/00 (20130101)
C09J 105/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308321 Kumar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey)
ASSIGNEE(S) THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey)
INVENTOR(S) Alok Kumar (Baltimore, Maryland);  Gan Zhou (Fair Lawn, New Jersey);  Xiaojun Yu (Fishers, Indiana)
ABSTRACT A scaffold has a spiral configuration and gradient porosity designed to facilitate the healing of bone injuries. To make the scaffold, a sheet of polymeric material or the like is rolled into a spiral shape. In one embodiment, the resulting scaffold has an outer porous layer with high porosity, and a comparatively less porous inner layer in order to facilitate vascularization and promote recovery. The pores can be filled with a degradable polymer and/or growth factors, bioactive molecules, bactericidal drugs and/or other compositions to further promote recovery.
FILED Friday, April 02, 2021
APPL NO 17/221730
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/28 (20130101)
A61F 2230/0091 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/10 (20130101)
A61L 27/18 (20130101) Original (OR) Class
A61L 27/56 (20130101)
A61L 27/446 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 80/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308322 Gu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Luo Gu (Cambridge, Massachusetts);  Ovijit Chaudhuri (San Mateo, California);  Nathaniel D. Huebsch (Colma, California);  David J. Mooney (Sudbury, Massachusetts);  Max Carlton Darnell (Somerville, Massachusetts);  Simon Young (Cambridge, Massachusetts)
ABSTRACT Provided are fast relaxing hydrogels that are useful for regulating cell behavior and enhancing tissue regeneration, e.g., bone regeneration.
FILED Tuesday, June 15, 2021
APPL NO 17/347915
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/20 (20130101) Original (OR) Class
A61L 27/52 (20130101)
A61L 27/54 (20130101)
A61L 27/56 (20130101)
A61L 27/3834 (20130101)
A61L 2400/12 (20130101)
A61L 2430/02 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0654 (20130101)
C12N 2506/1346 (20130101)
C12N 2513/00 (20130101)
C12N 2533/74 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308327 Kyriakides et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Themis Kyriakides (Branford, Connecticut);  Aaron Morris (Ann Arbor, Michigan)
ABSTRACT The present invention relates in part to compositions and methods for treating a wound, or location of interest, in mammal by administering a decellularized extracellular matrix (ECM) lacking thrombospondin-2 (TSP-2-null ECM). In certain embodiments, the invention provides an acellular composition comprising a decellularized TSP-2-null ECM. In certain embodiments, the invention provides a tunable hydrogel comprising a decellularized TSP-2-null ECM. The invention also provides, in certain embodiments, methods for accelerating cellular migration, methods for enhancing cellular invasion, methods for enhancing vascular growth and maturation of a region to be treated, and/or methods for enhancing a wound repair in a mammal in need thereof.
FILED Friday, October 19, 2018
APPL NO 16/757811
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101)
A61K 35/28 (20130101)
A61K 35/32 (20130101)
A61K 35/33 (20130101)
A61K 35/34 (20130101)
A61K 35/545 (20130101)
A61K 45/06 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/52 (20130101)
A61L 27/54 (20130101)
A61L 27/3633 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 17/02 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308459 Wagner et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Highland Instruments, Inc. (Somerville, Massachusetts)
ASSIGNEE(S) Highland Instruments, Inc. (Somerville, Massachusetts)
INVENTOR(S) Timothy Andrew Wagner (Somerville, Massachusetts);  Laura Dipietro (Cambridge, Massachusetts);  Uri Tzvi Eden (Somerville, Massachusetts)
ABSTRACT The invention generally relates to methods for guiding physical therapy to a subject. In certain embodiments, methods of the invention involve providing stimulation to a subject's central nervous system to modulate one or more signals sent to or from a plurality of target regions of the subject. Methods of the invention further involve assessing the response of the plurality of target regions to the stimulation to determine if there is a differential response among the target regions to the stimulation, and providing focused physical therapy to at least one of the target regions based on the assessment of the response of the plurality of peripheral target regions to the stimulation.
FILED Friday, April 02, 2021
APPL NO 17/221051
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/0408 (20130101)
A61N 1/36025 (20130101) Original (OR) Class
A61N 2/006 (20130101)
A61N 5/0622 (20130101)
A61N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308489 FRIEDMAN
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Integrated Sensors, LLC (Ottawa Hills, Ohio)
ASSIGNEE(S)
INVENTOR(S) Peter S. FRIEDMAN (Ottawa Hills, Ohio)
ABSTRACT Embodiments are directed generally to an ionizing-radiation beamline monitoring system that includes a vacuum chamber structure with vacuum compatible flanges through which an incident ionizing-radiation beam enters the monitoring system. Embodiments further include at least one scintillator within the vacuum chamber structure that can be at least partially translated in the ionizing-radiation beam while oriented at an angle greater than 10 degrees to a normal of the incident ionizing-radiation beam, a machine vision camera coupled to a light-tight structure at atmospheric/ambient pressure that is attached to the vacuum chamber structure by a flange attached to a vacuum-tight viewport window with the camera and lens optical axis oriented at an angle of less than 80 degrees with respect to a normal of the scintillator, and at least one ultraviolet (“UV”) illumination source facing the scintillator in the ionizing-radiation beam for monitoring a scintillator stability comprising scintillator radiation damage.
FILED Thursday, May 27, 2021
APPL NO 17/332047
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/00 (20130101)
A61N 5/1045 (20130101)
A61N 5/1048 (20130101)
A61N 5/1049 (20130101)
A61N 5/1064 (20130101)
A61N 5/1067 (20130101) Original (OR) Class
A61N 2005/1059 (20130101)

Measurement of Nuclear or X-radiation
G01T 1/40 (20130101)
G01T 1/1612 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308671 Scarabelli et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Leonardo Scarabelli (Los Angeles, California);  Gail Vinnacombe (Los Angeles, California);  Liv Heidenreich (Los Angeles, California);  Naihao Chiang (Los Angeles, California);  Yao Gong (Los Angeles, California);  Paul S. Weiss (Los Angeles, California);  Steven J. Jonas (Los Angeles, California)
ABSTRACT Systems and methods are disclosed that utilize metal nanostructures that are synthesized in situ along the internal surfaces of a microfluidic device. The nanostructures are formed by initial deposition of metallic seeds followed by flowing growth and reducing agent solutions into the capillaries/microfluidic channels to grow the nanostars. The nanostructures may optionally be functionalized with a capture ligand. The capture ligand may be used to selectively bind to certain cells (e.g., circulating tumor cells). The cells may be removed by a beam of light (e.g., laser beam) that induces localized heating at the surface location(s) containing the nanostructures. The plasmonic nature of the nanostructures can be used to heat the nanostructure(s) locally for the selective removal of one or certain cells. The nanostructures may be used to acquire Raman spectra of molecules or other small objects that are bound thereto for identification and quantification.
FILED Friday, August 16, 2019
APPL NO 17/268955
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/50273 (20130101) Original (OR) Class
B01L 3/502761 (20130101)
B01L 2300/0838 (20130101)
B01L 2300/0896 (20130101)
B01L 2400/0478 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 35/00 (20130101)

Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 7/00 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2004/03 (20130101)
C01P 2004/30 (20130101)
C01P 2004/64 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/658 (20130101)
G01N 21/6458 (20130101)
G01N 33/54346 (20130101)
G01N 33/57492 (20130101)
G01N 2021/656 (20130101)

Optical Elements, Systems, or Apparatus
G02B 21/006 (20130101)
G02B 21/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309606 Zhang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Zhong-Yin Zhang (West Lafayette, Indiana);  Kasi Viswanatharaju Ruddraraju (West Lafayette, Indiana)
ABSTRACT The present disclosure relates to novel N-aryl oxamic acid based inhibitors for Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB), and to the method of making and using the novel N-aryl oxamic acid based inhibitors. More specifically, compounds provided in this disclosure can be used to inhibit Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) and to treat a patient having a Tuberculosis disease.
FILED Monday, February 01, 2021
APPL NO 17/163650
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/06 (20180101)

Acyclic or Carbocyclic Compounds
C07C 235/74 (20130101) Original (OR) Class
C07C 317/14 (20130101)

Heterocyclic Compounds
C07D 215/48 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309616 OJIMA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Research Foundation for The State University of New York (Albany, New York)
ASSIGNEE(S)
INVENTOR(S) Iwao OJIMA (Port Jefferson, New York);  Vincent ALFORD (Sunnyvale, California);  Anushree KAMATH (Issaquah, Washington);  Jian CAO (S. Setauket, New York);  Xiadong REN (Port Jefferson Station, New York);  Nicole SAMPSON (Setauket, New York);  Monaf AWWA (Bel Air, Maryland)
ABSTRACT Small molecule inhibitors are claimed that selectively target the hemopexin domain of matrix metalloproteinase 9 (MMP-9) and do not inhibit the protease's catalytic functions. A method of treating cancer in a patient in need thereof with the compounds of the invention is also claimed.
FILED Monday, June 21, 2021
APPL NO 17/353075
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 239/56 (20130101)
C07D 239/95 (20130101) Original (OR) Class
C07D 403/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309617 Hagras et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Muhammad Hagras (Davis, California);  Alexei Stuchebrukhov (Davis, California)
ABSTRACT The present invention provides methods for inhibiting respiratory complex III in a cell. The present invention also provides methods for treating cancer in a subject.
FILED Friday, June 04, 2021
APPL NO 17/339620
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 35/42 (20130101)
C07C 43/295 (20130101)
C07C 49/577 (20130101)
C07C 205/45 (20130101)
C07C 271/58 (20130101)
C07C 317/44 (20130101)

Heterocyclic Compounds
C07D 243/24 (20130101) Original (OR) Class
C07D 309/14 (20130101)
C07D 407/04 (20130101)
C07D 493/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309651 TENG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Forge Therapeutics, Inc. (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) Min TENG (San Diego, California);  Baskar NAMMALWAR (San Diego, California);  David T. PUERTA (San Diego, California)
ABSTRACT Provided herein is an LpxC inhibitor compound, as well as methods of making and pharmaceutical compositions comprising said compound, and methods of use thereof in the treatment of disease that would benefit from treatment with an LpxC inhibitor, including gram-negative bacterial infections such as urinary tract infections and the like.
FILED Wednesday, March 24, 2021
APPL NO 17/211029
CURRENT CPC
Heterocyclic Compounds
C07D 413/14 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309662 Cook et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) UWM Research Foundation, Inc. (Milwaukee, Wisconsin);  Centre for Addiction and Mental Health (Toronto, Canada);  University of Belgrade - Faculty of Pharmacy (Belgrade, None)
ASSIGNEE(S)
INVENTOR(S) James M. Cook (Milwaukee, Wisconsin);  Guanguan Li (Milwaukee, Wisconsin);  Michael Ming-Jin Poe (Kalamazoo, Michigan);  Miroslav M. Savic (Belgrade, None);  Etienne Sibille (Toronto, Canada)
ABSTRACT Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them.
FILED Tuesday, December 15, 2020
APPL NO 17/122745
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/22 (20180101)

Heterocyclic Compounds
C07D 487/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309666 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Shaomeng Wang (Superior Township, Michigan);  Angelo Aguilar (Ann Arbor, Michigan);  Yangbing Li (Ann Arbor, Michigan);  Jiuling Yang (Ypsilanti, Michigan);  Donna McEachern (Ann Arbor, Michigan)
ABSTRACT The present disclosure provides compounds represented by Formula I: wherein R1a, R1b, R2a, R2b, R3a, R3b, R4, A, L, X, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat cancer or any other disease, condition, or disorder that is responsive to degradation of MDM2 protein.
FILED Wednesday, June 09, 2021
APPL NO 17/342974
CURRENT CPC
Heterocyclic Compounds
C07D 487/10 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309695 Kim
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)
INVENTOR(S) Kyung Bo Kim (Lexington, Kentucky)
ABSTRACT Unique compounds useful for inhibiting a proteasome in a cell, pharmaceutical compositions and methods of their use are provided herein.
FILED Tuesday, August 06, 2019
APPL NO 17/265344
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Peptides
C07K 5/123 (20130101) Original (OR) Class
C07K 5/126 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309701 Tak et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Yu Gyoung Tak (Charlestown, Massachusetts);  Benjamin Kleinstiver (Medford, Massachusetts);  J. Keith Joung (Winchester, Massachusetts)
ABSTRACT Drug-inducible, tunable, and multiplexable Clustered Regularly Interspaced Short Palindromic Repeats from Prevotella and Francisella 1 (Cpf1)-based activators, and methods of use thereof.
FILED Monday, April 23, 2018
APPL NO 16/606680
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/005 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/111 (20130101)
C12N 2310/20 (20170501)
C12N 2710/16222 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309702 Liu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Xuedong Liu (Denver, Colorado);  Xiaojuan Zhang (Denver, Colorado);  Zeyu Liu (Denver, Colorado);  Quanbin Xu (Denver, Colorado)
ABSTRACT The invention includes systems, methods, and compositions for designing secreted fusogenic ectosome vesicles, or gectosomes, that selectively encapsulate specific target proteins, nucleic acids and/or other small molecules in a predetermined manner. These engineered gectosomes can be used to deliver desired cargos to receipt cells in vitro, ex vivo, or in vivo and may further reprogram target cellular phenotypes in a dose-dependent manner, as well as perform genome editing functions, among others.
FILED Monday, February 01, 2021
APPL NO 17/164624
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5184 (20130101)
A61K 31/7088 (20130101)
A61K 38/465 (20130101)

Peptides
C07K 14/005 (20130101) Original (OR) Class
C07K 2319/035 (20130101)
C07K 2319/055 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 9/22 (20130101)
C12N 15/11 (20130101)
C12N 2310/20 (20170501)
C12N 2760/20022 (20130101)
C12N 2760/20033 (20130101)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309707 GARCIA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Kenan Christopher GARCIA (Menlo Park, California);  Juan Luis MENDOZA (Chicago, Illinois)
ABSTRACT Disclosed herein are compositions and methods for modulating IFN-γ-mediated signaling by completely or partially agonizing the downstream signal transduction mediated through at least one of the IFN-γ receptors. More particularly, the disclosure provides novel IFN-γ polypeptide variants with reduced binding affinity to at least one of its receptors. The disclosure also provides compositions and methods useful for producing such molecules, as well as methods for the treatment of health diseases associated with the perturbation of signal transduction mediated by IFN-γ.
FILED Monday, July 29, 2019
APPL NO 17/264140
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/217 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/57 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309714 Kuhns et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona);  JOSLIN DIABETES CENTER, INC. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Michael S Kuhns (Tucson, Arizona);  Thomas Serwold (Boston, Massachusetts)
ABSTRACT Chimeric receptors featuring major histocompatibility molecules grafted onto T cell receptor molecules and surrogate co-receptors featuring cell surface receptor ligands fused with signaling molecule domains. The chimeric receptors can be used to redirect cells, altering their specificity. T cells expressing chimeric receptors may bind to TCRs of target T cells for which their chimeric receptors are specific. Surrogate co-receptors may be used to help enhance TCR-CD3 signaling as part of this modular receptor system. The chimeric receptors and surrogate coreceptors may be used to help eliminate autoreactive T cells or program T cells to desired effector functions.
FILED Friday, June 11, 2021
APPL NO 17/345425
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)

Peptides
C07K 14/705 (20130101)
C07K 14/7051 (20130101)
C07K 14/70539 (20130101) Original (OR) Class
C07K 2319/02 (20130101)
C07K 2319/03 (20130101)
C07K 2319/74 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101)
C12N 9/12 (20130101)

Enzymes
C12Y 207/10002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309729 Cukierman et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
U.S. Army Medical Research and Development Command (USAMRDC)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Institute For Cancer Research d/b/a The Research Institute of Fox ChaseCancer Center (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Edna Cukierman (Philadelphia, Pennsylvania);  Ralph Francescone (Philadelphia, Pennsylvania);  Janusz Franco-Barraza (Philadelphia, Pennsylvania);  Kristopher Raghavan (Philadelphia, Pennsylvania)
ABSTRACT The present disclosure provides methods of inducing desmoplastic stroma to express a normal phenotype by detecting increased levels of NetG1 or NGL1 in tumor or in desmoplastic stroma isolated from a human subject, and/or detecting NetG1 in circulating extracellular vesicles, and/or detecting increased pFAK in the stroma, and treating the human subject with a therapeutic regimen; and by detecting NetG1 in a microvesicle isolated from a human subject, and/or treating the human subject with a therapeutic regimen.
FILED Tuesday, October 09, 2018
APPL NO 16/754877
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/217 (20130101)

Peptides
C07K 16/22 (20130101) Original (OR) Class
C07K 16/2818 (20130101)
C07K 16/2827 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57484 (20130101)
G01N 2800/7028 (20130101)
G01N 2800/7052 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309737 FESSLER et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as Represented By The Secretary, Department of Health and Human Servic (Bethesda, Maryland)
ASSIGNEE(S) The United States of America, as Represented By The Secretary, Department of Health and Human Servic (Bethesda, Maryland)
INVENTOR(S) Michael Brian FESSLER (Cary, North Carolina);  Carmen J. WILLIAMS (Chapel Hill, North Carolina);  Wan-Chi LIN (Morisville, North Carolina)
ABSTRACT Disclosed herein are methods of treating or preventing a lung disorder comprising administering to a subject a composition comprising an agent that modulates activity and/or expression of Epithelial Membrane Protein 2 (EMP2) in an amount effective to treat or prevent the lung disorder and compositions useful in such for methods.
FILED Tuesday, April 30, 2019
APPL NO 17/051678
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 11/00 (20180101)

Peptides
C07K 16/28 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6893 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309750 Sampson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) John H. Sampson (Durham, North Carolina);  Patrick C. Gedeon (Durham, North Carolina);  Bryan D. Choi (Durham, North Carolina)
ABSTRACT Enhancing the delivery of therapeutic, diagnostic and other useful compounds to the brain and other tissues permits more effective use of reagents and use of lower doses. Our method permits enhanced delivery of molecules that are diagnostically, therapeutically, or otherwise useful to specific tissues in the body, including the central nervous system (CNS). Large, hydrophilic molecules, such as antibodies, are typically restricted from entering the CNS by the blood-brain barrier and fail to accumulate to therapeutic levels within the brain. Our method permits enhanced penetrance of the CNS by peripherally administered antibodies. Our method can be applied to enhance the delivery of a variety of therapeutic, diagnostic, and otherwise useful molecules to any tissue, many of which have previously been clinically ineffective due to poor tissue penetrance.
FILED Wednesday, August 07, 2019
APPL NO 17/265731
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)
A61K 39/3955 (20130101)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/2809 (20130101)
C07K 16/2863 (20130101) Original (OR) Class
C07K 2317/31 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309778 Bolskar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) TDA Research, Inc. (Wheat Ridge, Colorado)
ASSIGNEE(S)
INVENTOR(S) Robert Donald Bolskar (Arvada, Colorado);  James William Raebiger (Golden, Colorado);  Rhia M. Martin (Arvada, Colorado);  Sylvia DeVito Luebben (Golden, Colorado)
ABSTRACT Crosslink-forming monomers, comprising reverse-acrylate groups, and crosslinked polymer networks formed by the polymerization of monomers that comprise said reverse-acrylate crosslink-forming monomers. Crosslink-forming monomers, comprising reverse-acrylate groups, comprising an alkyl, an aryl, an alkoxyl, and an alkylamino group bridging one or more reverse-acrylate groups. Crosslink-forming monomers, comprising reverse-acrylate groups, comprising an alkyl, an aryl, an alkoxyl, and an alkylamino ester groups. Crosslink-forming monomers, comprising reverse-acrylate groups, comprising alkyl groups where the group is selected from the group consisting of a methyl, an ethyl, a propyl, an n-butyl and a t-butyl. Reverse-acrylate crosslink-forming monomers comprise a chemical structure where the two or more polymerizable carbon-carbon double bonds are connected by a crosslinking group on the opposite side of the hydrolysable ester groups relative to normal crosslinking acrylate monomers. The crosslink-forming monomers herein form crosslinked polymer networks that do not lose their crosslinking upon hydrolysis of the ester linkages.
FILED Tuesday, March 16, 2021
APPL NO 17/203648
CURRENT CPC
Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 222/1025 (20200201) Original (OR) Class
C08F 2438/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309822 BULGER et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) PALO ALTO RESEARCH CENTER INCORPORATED (Palo Alto, California)
ASSIGNEE(S)
INVENTOR(S) ELI BULGER (NOTTAWA, Canada);  MAHATI CHINTAPALLI (MOUNTAIN VIEW, California);  GABRIEL IFTIME (DUBLIN, California);  QUENTIN VAN OVERMEERE (MOUNTAIN VIEW, California);  JESSICA LOUIS BAKER RIVEST (PALO ALTO, California);  RAVI NEELAKANTAN (REDWOOD CITY, California);  STEPHEN MECKLER (REDWOOD CITY, California)
ABSTRACT A method of producing a polymer aerogel includes dissolving precursors into a solvent, wherein the precursors include monomers, crosslinkers, a controlling agent and an initiator to form a precursor solution, wherein at least one of the monomers or at least one of the crosslinkers has a refractive index of 1.5 or lower, polymerizing the precursor solution to form a gel polymer, and removing the solvent from the gel polymer to produce the polymer aerogel. A method of producing a polymer aerogel include dissolving precursors into a solvent, wherein the precursors include monomers, crosslinkers, a controlling agent and an initiator to form a precursor solution, polymerizing the precursor solution to form a gel polymer, removing the solvent from the gel polymer to produce the polymer aerogel, and reducing a refractive index of one of either the gel polymer or the polymer aerogel.
FILED Friday, April 30, 2021
APPL NO 17/245418
CURRENT CPC
Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/242 (20130101)
C08J 9/0004 (20130101) Original (OR) Class
C08J 9/286 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 5/0025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309965 Haining et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Mental Health (NIMH)
APPLICANT(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts);  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania);  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) William N. Haining (Newton, Massachusetts);  Debattama SEN (Cambridge, Massachusetts);  E John WHERRY (Havertown, Pennsylvania);  Nir YOSEF (Richmond, California);  James KAMINSKI (Berkeley, California);  Kristen PAUKEN (Jamaica Plain, Massachusetts)
ABSTRACT The present invention is based on the identification of T-cell exhaustion state-specific gene expression regulators, as well as uses thereof.
FILED Tuesday, March 21, 2017
APPL NO 16/086719
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)
A61K 45/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101) Original (OR) Class
C12N 15/102 (20130101)
C12N 2310/20 (20170501)
C12N 2510/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309969 MILLER et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Jeffrey MILLER (Minneapolis, Minnesota);  Frank CICHOCKI (Minneapolis, Minnesota);  Yenan BRYCESON (Stockholm, Sweden);  Heinrich SCHLUMS (Stockholm, Sweden)
ABSTRACT This disclosure describes an adaptive NK cell, an isolated population of adaptive Natural Killer (NK) cells, a composition including an adaptive NK cell, and methods for producing, preparing, and using an adaptive NK cell or an isolated population or composition including an adaptive NK cell. The adaptive NK cells may be used to treat a viral infection or a tumor.
FILED Wednesday, April 07, 2021
APPL NO 17/224966
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)
A61K 39/245 (20130101)
A61K 45/06 (20130101)
A61K 2039/572 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0646 (20130101) Original (OR) Class
C12N 7/00 (20130101)
C12N 2501/42 (20130101)
C12N 2501/2315 (20130101)
C12N 2501/2321 (20130101)
C12N 2502/1352 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309975 Bowie et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) James U. Bowie (Los Angeles, California);  Meaghan Valliere (Leominster, Massachusetts);  Tyler P. Korman (Sierra Madre, California);  Nicholas Woodall (Knoxville, Tennessee)
ABSTRACT Provided is an enzyme useful for prenylation and recombinant pathways for the production of cannabinoids, cannabinoid precursors and other prenylated chemicals in a cell free system as well and recombinant microorganisms that catalyze the reactions.
FILED Thursday, August 01, 2019
APPL NO 17/264758
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1085 (20130101) Original (OR) Class

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/22 (20130101)
C12P 7/42 (20130101)
C12P 9/00 (20130101)
C12P 17/06 (20130101)

Enzymes
C12Y 205/01039 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309984 Garnett et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) King's College London (London, United Kingdom);  Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) James Garnett (London, United Kingdom);  Nicholas P. Cianciotto (Chicago, Illinois)
ABSTRACT There is disclosed a peptide with mucolytic activity, The peptide comprising an amino acid sequence having at least 60% sequence identity to the amino add sequence defined in SEQ ID NO: 1, but does not consist of the amino sequence defined in SEQ ID NO: 2.
FILED Tuesday, April 06, 2021
APPL NO 17/223743
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/2442 (20130101) Original (OR) Class

Enzymes
C12Y 302/01014 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/573 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309986 PEREZ-PINERA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of General Medical Sciences (NIGMS)
Non-Profit Organization (NPO)
American Heart Association (AHA)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S) Pablo PEREZ-PINERA (Urbana, Illinois);  Michael P. GAPINSKE (Urbana, Illinois);  Jackson Scott WINTER (Palatine, Illinois)
ABSTRACT The disclosure provides a versatile method termed CRISPR-SKIP that utilizes cytidine and/or adenine deaminase base editors to program exon skipping by mutating target DNA bases within splice acceptor sites and/or splice enhancer sites. Given its simplicity and precision, CRISPR-SKIP will be broadly applicable in gene therapy and synthetic biology
FILED Friday, July 19, 2019
APPL NO 17/260828
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)
A61P 43/00 (20180101)

Peptides
C07K 2319/80 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 9/78 (20130101) Original (OR) Class
C12N 15/11 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)

Enzymes
C12Y 305/04004 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309998 Chan
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Stephen Yu-Wah Chan (Pittsburgh, Pennsylvania)
ABSTRACT Provided herein are methods of treating a coronavirus infection in a patient, comprising administering an agent to the patient in an amount effective to increase cellular lysosomal pH in cells of the patient. As provided herein, the agent is one or more of an agent for reducing expression or activity of nuclear receptor coactivator 7 (NCOA7) in the patient, an RNAi agent or antisense reagent for knocking down expression of a v-rel avian reticuloendotheliosis viral oncogene homolog A (RelA/p65) transcript, or a janus kinase (JAK) inhibitor, thereby increasing cellular lysosomal pH in cells of the patient.
FILED Wednesday, March 31, 2021
APPL NO 17/218604
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/5377 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 15/1135 (20130101)
C12N 2310/11 (20130101)
C12N 2310/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310000 KATO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) CITY OF HOPE (Duarte, California)
ASSIGNEE(S)
INVENTOR(S) Mitsuo KATO (Duarte, California);  Rama NATARAJAN (Duarte, California)
ABSTRACT The present disclosure relates to isolated compounds including a nucleic acid sequence capable of hybridizing to an RNA sequence 10 to 270 nucleobases downstream of the transcription start site of a mammalian microRNA-379 transcript; methods of treating a condition of a subject (e.g., diabetes, obesity, or complications thereof) with the compounds; and methods of inhibiting expression of a mammalian microRNA-379 megacluster with the compounds.
FILED Friday, August 16, 2019
APPL NO 17/268068
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0276 (20130101)
A01K 67/0278 (20130101)
A01K 2217/072 (20130101)
A01K 2217/075 (20130101)
A01K 2227/105 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7125 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/04 (20180101)
A61P 3/10 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/113 (20130101)
C12N 2310/315 (20130101)
C12N 2310/341 (20130101)
C12N 2310/346 (20130101)
C12N 2310/3231 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310003 Yen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Baylor College of Medicine (Houston, Texas)
ASSIGNEE(S)
INVENTOR(S) Laising Yen (Pearland, Texas);  Liming Luo (Pearland, Texas);  Pei-Wen Chao (Sugar Land, Texas)
ABSTRACT Embodiments of the disclosure concern the use of expression constructs in which at least one polyA signal is embedded upstream of an expressible transcript, such as within a 5′ UTR for the transcript, for example. In certain embodiments, the polyA signal is comprised within a ligand-binding aptamer, and the binding of the ligand to the aptamer, or lack thereof, dictates the outcome for the expressible transcript. In specific embodiments, absence of the ligand causes the expressed transcript having a polyA in its 5′ UTR to be expressed but then degraded, whereas presence of the ligand causes inhibition of degradation upon expression of the expressible transcript. More than one ligand-binding aptamer may be present on the same expression construct.
FILED Friday, January 08, 2021
APPL NO 17/144456
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 48/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/67 (20130101)
C12N 15/115 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310007 AN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California)
INVENTOR(S) Dong Sung AN (Los Angeles, California);  Saki SHIMIZU (BERKELEY, California)
ABSTRACT A potent short hairpin RNA (shRNA734) directed to human Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) improves the rate of gene-modified stem cell engraftment by a conditioning and in vivo selection strategy to confer resistance to a clinically available guanine analog antimetabolite, 6TG, for efficient positive selection of gene-modified stem cells. Uses for polynucleotides comprising the shRNA734 include methods for knocking down HPRT in a cell, for conferring resistance to a guanine analog antimetabolite in a cell, for producing selectable genetically modified cells, for selecting cells genetically modified with a gene of interest from a plurality of cells, for removing cells genetically modified with a gene of interest from a plurality of cells, and for treating a subject infected with HIV.
FILED Friday, February 17, 2017
APPL NO 15/999854
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/28 (20130101)
A61K 45/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0081 (20130101)
C12N 15/86 (20130101)
C12N 15/1137 (20130101) Original (OR) Class
C12N 2310/531 (20130101)
C12N 2740/15043 (20130101)

Enzymes
C12Y 204/02008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310008 Parker et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Roy R. Parker (Boulder, Colorado);  Shukla Siddharth (Boulder, Colorado)
ABSTRACT Increased PARN as an indicator of a cancer involving loss or reduction in p53 function. PARN is also provided as a therapeutic target for treating a cancer involving loss or reduction in p53 function. Methods of treating a subject having a cancer involving loss or reduction in p53 function based on the level of PARN in a test sample obtained from the subject and administering an effective amount of a PARN inhibitor, alone or in conjunction with another chemotherapeutic agent, to the subject to treat the cancer.
FILED Wednesday, August 07, 2019
APPL NO 17/266502
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/704 (20130101)
A61K 31/7125 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1137 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2310/315 (20130101)
C12N 2320/31 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310016 CORUZZI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Organismal Systems (IOS)
APPLICANT(S) New York University (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Gloria M. CORUZZI (New York, New York);  Matthew BROOKS (White Plains, New York);  Kranthi VARALA (West Lafayette, Indiana)
ABSTRACT Methods for increasing or decreasing Nitrogen (N) uptake/assimilation and/or usage in plants comprising over-expressing or repressing one or more transcription factors that have been identified by evaluating temoporal transcription of the TFs in response to N signaling and validated based on TF perturbation studies in plant cells and plants. Combinations of TFs may be used, where each TF may be independently induced or repressed to achieve a desired increase or decrease in N uptake/assimilation.
FILED Friday, June 22, 2018
APPL NO 16/625286
CURRENT CPC
Peptides
C07K 14/415 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/111 (20130101)
C12N 15/113 (20130101)
C12N 15/8241 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
C12N 2310/141 (20130101)
C12N 2320/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310022 Lu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Timothy Kuan-Ta Lu (Cambridge, Massachusetts);  Alan Siu Lun Wong (Ma On Shan, China Hong Kong);  Ching Gee Choi (Tai Wai, China Hong Kong)
ABSTRACT Described herein are methods and compositions that enable rapid generation of high-order combinations of genetic elements comprising a CRISPR guide sequence and a scaffold sequence, and a barcode for rapid identification of the combination of genetic elements encoded within a single cell or a pooled population. Also described herein compositions of inhibitors of epigenetic genes and methods for reducing cell proliferation and/or treating cancer.
FILED Thursday, June 03, 2021
APPL NO 17/338027
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/55 (20130101)
A61K 31/4709 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101) Original (OR) Class
C12N 15/102 (20130101)
C12N 2310/20 (20170501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310046 Seelig et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Georg Seelig (Seattle, Washington);  Richard Muscat (Seattle, Washington);  Alexander B. Rosenberg (Seattle, Washington)
ABSTRACT Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
FILED Tuesday, December 15, 2020
APPL NO 17/122321
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101) Original (OR) Class
C12Q 1/6855 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310055 SCHWARTZ et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) David Charles SCHWARTZ (Madison, Wisconsin);  Subhrangshu NANDI (Madison, Wisconsin);  Michael Abbott NEWTON (Madison, Wisconsin)
ABSTRACT Systems and methods for identifying sequence information from measurements made on single nucleic acid molecules are disclosed. The systems and methods can include binding portions of nucleic acid molecules with marker molecules, such as fluorescent molecules and/or intercalating molecules. The marker molecules provide a detectable signal that includes information about the underlying genomic information of the location on the nucleic acid molecule where a given marker molecule is bound. A profile of the detectable signal along a position of the nucleic acid is acquired for multiple different nucleic acid molecules. The PRIMR algorithm processes the data to provide a consensus profile from which a consensus underlying genomic information can be determined.
FILED Tuesday, December 04, 2018
APPL NO 16/769883
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6818 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6428 (20130101)
G01N 21/6458 (20130101)
G01N 2021/6439 (20130101)

Optical Elements, Systems, or Apparatus
G02B 21/16 (20130101)
G02B 21/365 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/0014 (20130101)
G06K 9/036 (20130101)
G06K 9/00134 (20130101)
G06K 9/00147 (20130101)
G06K 2209/05 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 30/00 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310058 AKILESH et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Shreeram AKILESH (Seattle, Washington);  John A. STAMATOYANNOPOULOS (Seattle, Washington);  Alessandra SULLIVAN (Seattle, Washington);  William KERWIN (Seattle, Washington);  Tobias RAGOCZY (Seattle, Washington);  Pavel ZRAZHEVSKIY (Seattle, Washington)
ABSTRACT Disclosed herein are methods of detecting a target viral nucleic acid sequence, determining the localization of the target viral nucleic acid sequence, and/or quantifying the number of target viral nucleic acid sequences in a cell. This method may be used on small target nucleic acid sequences, and may be referred to as Nano-FISH or viral Nano-FISH.
FILED Thursday, July 19, 2018
APPL NO 16/631632
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6841 (20130101) Original (OR) Class
C12Q 1/6876 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310061 Makrigiorgos et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S) Gerassimos Makrigiorgos (Chestnut Hill, Massachusetts);  Ka Wai Leong (Melrose, Massachusetts);  Fangyan Yu (Dorchester, Massachusetts)
ABSTRACT Disclosed herein are compositions and methods for isothermal amplification of dsDNA without the use of primers. The dis-closed compositions and methods may be used for the generation of probes used in hybrid-capture techniques that usually precede sequencing. Methods of using the probes for capturing target DNA are also provided.
FILED Friday, August 16, 2019
APPL NO 17/268941
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6811 (20130101)
C12Q 1/6853 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310062 HE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S) The University of Chicago (Chicago, Illinois)
INVENTOR(S) Chuan HE (Chicago, Illinois);  Ji NIE (Chicago, Illinois);  Xiao-Long CUI (Chicago, Illinois)
ABSTRACT The methods, compositions, and kits of the disclosure provide a novel approach for a whole genome, unbiased DNA analysis method that can be performed on limited amounts of DNA. can be used to analyze DNA to determine its modification status. Aspects of the disclosure relate to a method for amplifying bisulfite-treated deoxyribonucleic acid (DNA) molecules comprising: (a) ligating an adaptor to the DNA molecules, wherein the adaptor comprises a RNA polymerase promoter comprising bisulfite-protected cytosines; (b) treating the ligated DNA molecules with bisulfite; (c) hybridizing the bisulfite-treated DNA molecules with a primer; (d) extending the hybridized primer to make double stranded DNA; and (e) in vitro transcribing the double-stranded DNA to make RNA.
FILED Friday, July 26, 2019
APPL NO 17/250365
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6865 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310068 Nelson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) Fred Hutchinson Cancer Research Center (Seattle, Washington)
ASSIGNEE(S) Fred Hutchinson Cancer Research Center (Seattle, Washington)
INVENTOR(S) J. Lee Nelson (Seattle, Washington);  Nathalie C. Lambert (Marseille, France);  Vijayakrishna K. Gadi (Seattle, Washington);  Zhen Yan (Irving, Texas)
ABSTRACT The present disclosure provides a panel of nucleic acid molecule primers specific for HLA-specific alleles and other genetic polymorphisms, which are useful for quantitatively amplifying these markers to detect, diagnose, and monitor individuals who have or are at risk of certain disease conditions, such as autoimmune disease, proliferative disease, infectious disease, allograft rejection, or pregnancy-related pathologies.
FILED Thursday, June 17, 2021
APPL NO 17/351135
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6881 (20130101) Original (OR) Class
C12Q 1/6883 (20130101)
C12Q 2600/156 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310084 de Vlaminck et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Iwijn de Vlaminck (Stanford, California);  Michael Kertesz (Menlo Park, California);  Kiran Kaur Khush (Stanford, California);  Mark Alec Kowarsky (Kowarsky, Australia);  Lance Martin (Half Moon Bay, California);  Stephen R. Quake (Stanford, California);  Hannah Valantine (Stanford, California)
ABSTRACT Methods, devices, compositions and kits are provided for analysis of the microbiome or individual components thereof in an individual. The methods find use in a determination of infection, in analysis of the microbiome structure, in determining the immunocompetence of an individual, and the like. In some embodiments of the invention, the individual is treated with an therapeutic regimen, e.g. drugs, diet, radiation therapy, and the like.
FILED Monday, June 14, 2021
APPL NO 17/347138
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101)
C12Q 1/701 (20130101)
C12Q 1/705 (20130101) Original (OR) Class
C12Q 1/6883 (20130101)
C12Q 1/6895 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/00 (20190201)
G16B 20/20 (20190201)
G16B 30/00 (20190201)
G16B 30/10 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310085 de Vlaminck et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Iwijn de Vlaminck (Stanford, California);  Michael Kertesz (Menlo Park, California);  Kiran Kaur Khush (Stanford, California);  Mark Alec Kowarsky (Kowarsky, Australia);  Lance Martin (Half Moon Bay, California);  Stephen R. Quake (Stanford, California);  Hannah Valantine (Stanford, California)
ABSTRACT Methods, devices, compositions and kits are provided for analysis of the microbiome or individual components thereof in an individual. The methods find use in a determination of infection, in analysis of the microbiome structure, in determining the immunocompetence of an individual, and the like. In some embodiments of the invention, the individual is treated with an therapeutic regimen, e.g. drugs, diet, radiation therapy, and the like.
FILED Monday, June 14, 2021
APPL NO 17/347180
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101)
C12Q 1/701 (20130101)
C12Q 1/705 (20130101) Original (OR) Class
C12Q 1/6883 (20130101)
C12Q 1/6895 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/00 (20190201)
G16B 20/20 (20190201)
G16B 30/00 (20190201)
G16B 30/10 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310788 Zawadzki et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Robert J. Zawadzki (Sacramento, California);  Edward N. Pugh, JR. (Davis, California);  Pengfei Zhang (Davis, California)
ABSTRACT Systems, apparatus and methods that modulate the phase inside the imaging system pupil aperture with a segmented deformable mirror, spatial light modulator (SLM), or liquid deformable lens (LDL) to produce minor perturbations in the point spread function (PSF) and create un-correlated speckle patterns between B-scans.
FILED Thursday, February 04, 2021
APPL NO 17/168043
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 9/02082 (20130101) Original (OR) Class
G01B 9/02091 (20130101)

Image Data Processing or Generation, in General
G06T 7/248 (20170101)
G06T 2207/10101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310910 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Feng Wang (Fremont, California);  David Agard (Burlingame, California);  Yifan Cheng (San Francisco, California);  Eugene Palovcak (San Francisco, California)
ABSTRACT Herein are innovations that enable facile cryo-EM analysis of diverse samples. Methods of functionalizing sample grids for cryo-EM are described, including methods of creating high quality graphene oxide films on cryo-EM substrates. The cryo-EM sample substrates are functionalized with affinity molecules that efficiently concentrate sample molecules and other specimen types on the grid, away from the air-water interface. Affinity groups include amines and proteins such as tagging system proteins and peptides that can be used to capture diverse sample types with high affinity. Optionally, spacers such as PEG chains are used to place sample particles away from the substrate surface, reducing substrate-induced artifacts.
FILED Monday, August 19, 2019
APPL NO 17/269466
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 32/198 (20170801)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/42 (20130101)
G01N 1/2813 (20130101) Original (OR) Class
G01N 23/2202 (20130101)
G01N 23/2204 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 37/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310928 Huang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
APPLICANT(S) Jie Huang (Rolla, Missouri);  Chen Zhu (Rolla, Missouri);  Rex E. Gerald, II (Willow Springs, Illinois)
ASSIGNEE(S) The Curators of the University of Missouri (Columbia, Missouri)
INVENTOR(S) Jie Huang (Rolla, Missouri);  Chen Zhu (Rolla, Missouri);  Rex E. Gerald, II (Willow Springs, Illinois)
ABSTRACT An open-ended hollow coaxial cable resonator probe configured to receive an aerosol sample for analysis. A metal post shorts the resonator's inner and outer conductors. A metal plate is spaced apart from an open end of the resonator by a dielectric layer that contains the received aerosol sample. Interrogator circuitry coupled to the resonator transmits an electromagnetic wave within the resonator and generates an electric field at the open end of the resonator. The interrogator circuitry is responsive to the generated electric field for determining a resonance frequency and an impedance of the resonator when the aerosol sample is present in the dielectric layer and is configured to identify virus particles in the aerosol sample as a function of the determined resonance frequency and impedance. A portable aerosol analyzer comprises the open-ended hollow coaxial cable resonator and a mouthpiece through which a subject expels a breath sample into the open end of the resonator. Antibodies tethered to high-permittivity nanoparticles attach to pathogens selectively, resulting in enhanced sensing with molecular-level specificity.
FILED Tuesday, March 23, 2021
APPL NO 17/209785
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/24 (20130101)
G01N 15/0618 (20130101)
G01N 15/0656 (20130101) Original (OR) Class
G01N 33/497 (20130101)
G01N 2001/245 (20130101)
G01N 2033/4975 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310970 NOLAN et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) GARRY P. NOLAN (Redwood City, California);  Sean C. Bendall (San Mateo, California);  Robert M. Angelo (Menlo Park, California)
ABSTRACT A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.
FILED Tuesday, October 06, 2020
APPL NO 17/064311
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 23/2258 (20130101) Original (OR) Class
G01N 33/4833 (20130101)
G01N 33/5005 (20130101)
G01N 33/5008 (20130101)
G01N 33/6848 (20130101)
G01N 2458/15 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 49/14 (20130101)
H01J 49/0036 (20130101)
H01J 49/142 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310976 Lamberg et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S) Milo Sensors, Inc. (Santa Barbara, California)
ASSIGNEE(S)
INVENTOR(S) Peter Lamberg (Santa Barbara, California);  Bob M. Lansdorp (Santa Barbara, California)
ABSTRACT Maintaining functionality in a device reliant on active biocatalysts. A water-impermeable container has one or more biocatalysts mixed and packed with stabilizers to function as a slow-release device. Depending on its adjustable geometries the device will provide a modifiable trickle of biocatalysts into a liquid released from a dry and stable state.
FILED Friday, April 02, 2021
APPL NO 17/301440
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 2/28 (20130101)
B01J 31/003 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0006 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/327 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310987 Xie et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Ping Xie (Needham, Massachusetts);  Charles M. Lieber (Lexington, Massachusetts)
ABSTRACT There is provided a nanopore sensor including cis and trans fluidic reservoirs. A nanopore is provided in a support structure separating the cis and trans reservoirs. The nanopore has an inlet in fluidic connection with the cis fluidic reservoir and an outlet in fluidic connection with the trans fluidic reservoir. The cis fluidic reservoir has a fluidic access resistance, RC, the trans fluidic reservoir has a fluidic access resistance, RT, and the nanopore has a fluidic resistance, RP. RP is of the same order of magnitude as RT and both RP and RT are at least an order of magnitude greater than RC. An electrical transduction element is disposed at a nanopore sensor site that exposes the transduction element to the trans reservoir. An electrical circuit is connected to the electrical transduction element for producing an electrical signal indicative of changes in electrical potential local to the trans reservoir.
FILED Monday, June 14, 2021
APPL NO 17/346636
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 15/00 (20130101)
B82Y 30/00 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6869 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/447 (20130101) Original (OR) Class
G01N 33/48721 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311025 Liu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Fei Liu (Mountain View, California);  Utkan Demirci (Stanford, California);  Sanjiv Sam Gambhir (Stanford, California);  Viswam S. Nair (Tampa, Florida)
ABSTRACT A device (“the ExoTIC device”) for the isolation of extracellular vesicles from an extracellular vesicle-containing sample in which the sample is flowed through a membrane in a flow chamber to capture and purify the extracellular vesicles on the membrane. The extracellular vesicles may be washed and collected and utilized in any one of a number of ways including, but not limited to, identifying biomarkers of a disease, identifying the presence of a biomarker in a patient to determine whether a patient has a disease, and therapeutically treating existing diseases by re-introducing the extracellular vesicles, potentially modified, back into a body.
FILED Friday, June 11, 2021
APPL NO 17/345968
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/50273 (20130101)
B01L 3/502715 (20130101)
B01L 3/502761 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/50 (20130101)
G01N 33/5005 (20130101)
G01N 33/5091 (20130101) Original (OR) Class
G01N 33/5308 (20130101)
G01N 2800/52 (20130101)
G01N 2800/56 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311035 THURMOND
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Non-Profit Organization (NPO)
Juvenile Diabetes Research Foundation (JDRF)
APPLICANT(S) CITY OF HOPE (Duarte, California)
ASSIGNEE(S) CITY OF HOPE (Duarte, California)
INVENTOR(S) Debbie C. THURMOND (Glendora, California)
ABSTRACT Disclosed is the use of DOC2B as an early stage biomarker for diagnosing type 1 diabetes (T1D), pre-T1D, type 2 diabetes (T2D), pre-T2D or for assessing the risk of T1D, pre-T1D, T2D, or pre-T2D. Also disclosed are methods of in vivo diagnosing T1D, pre-T1D, T2D, or pre-T2D or assessing the risk of T1D, pre-T1D, T2D, or pre-T2D by detecting a reduced level of DOC2B expression in a biological sample including blood, plasm, serum, platelets, and pancreatic islets.
FILED Thursday, April 15, 2021
APPL NO 17/231986
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/39 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/543 (20130101) Original (OR) Class
G01N 2333/4703 (20130101)
G01N 2800/042 (20130101)
G01N 2800/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311050 Winslow et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Research Foundation for the STATE UNIVERSITY OF NEW YORK (Albany, New York)
ASSIGNEE(S)
INVENTOR(S) Gary Winslow (Syracuse, New York);  Russell Levack (Tully, New York)
ABSTRACT The present disclosure is directed to methods of treating a disease associated with pathogenic B cells comprising administering to a subject in need thereof an effective amount of an Adora2A (adenosine A2A receptor) agonist. The method more specifically comprises: (a) obtaining a biological sample from a subject, wherein the sample comprises B cells; (b) detecting in the sample the presence of pathogenic B cells; (c) administering to the subject a pharmaceutically effective dose of an Adora2A receptor agonist (A2aR agonist) if pathogenic B cells are detected in step (b). The method may further comprise administering to the subject subsequent doses of a pharmaceutically effective dose of the A2aR agonist until pathogenic B cells are no longer detected.
FILED Thursday, August 08, 2019
APPL NO 17/265099
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7076 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56972 (20130101) Original (OR) Class
G01N 2800/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311057 Janssen-Heininger et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Research Resources (NCRR)
National Heart, Lung, and Blood Institute (NHLBI)
U.S. Public Health Service (USPHS)
APPLICANT(S) The University of Vermont and State Agricultural College (Burlington, Vermont);  Universiteit Maastricht (Maastricht, Netherlands)
ASSIGNEE(S) The University of Vermont and State Agricultural College (Burlington, Vermont);  Universiteit Maastricht (Maastricht, Netherlands)
INVENTOR(S) Yvonne M. Janssen-Heininger (Charlotte, Vermont);  Niki Reynaert (Maasmechelen, Belgium)
ABSTRACT The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc. As a specific example, a glutathionylated moiety on a glutathionylated protein may be reacted with an alkylating agent to form an alkylthio moiety; the alkylthio moiety may include a detection entity or otherwise be able to interact with a signaling entity. In some embodiments, other moieties on the protein may be altered or blocked before reaction of the protein with the detection entity. Such moieties on the protein may be, for instance, non-oxidized or non-glutathionylated moieties able to react with the detection entity. As a particular example, in a protein containing a glutathionylated moiety and non-glutathionylated thiol moieties, the thiol moieties may first be altered or blocked prior to reaction of the protein with the detection entity. Also provided in certain aspects of the present invention are kits for determining oxidized proteins, which may include components such as detection entities, alkylating agents, blocking agents, reducing agents, signaling entities, binding partners, antibodies, instructions, and the like.
FILED Monday, February 22, 2021
APPL NO 17/181160
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/58 (20130101)
G01N 33/573 (20130101) Original (OR) Class
G01N 33/6815 (20130101)
G01N 33/6842 (20130101)
G01N 33/6893 (20130101)
G01N 2333/902 (20130101)
G01N 2800/24 (20130101)
G01N 2800/122 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311058 Rissin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Quanterix Corporation (Billerica, Massachusetts)
ASSIGNEE(S) Quanterix Corporation (Billerica, Massachusetts)
INVENTOR(S) David M. Rissin (Somerville, Massachusetts);  David Fournier (Northborough, Massachusetts);  David C. Duffy (Arlington, Massachusetts)
ABSTRACT Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.
FILED Tuesday, March 23, 2021
APPL NO 17/210258
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6428 (20130101)
G01N 21/6452 (20130101)
G01N 33/573 (20130101) Original (OR) Class
G01N 33/54313 (20130101)
G01N 33/54366 (20130101)
G01N 2201/062 (20130101)
G01N 2333/924 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311062 Geskin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
APPLICANT(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
INVENTOR(S) Larisa J. Geskin (Riverdale, New York);  Brittany Lynn O'Neill Dulmage (Pittsburgh, Pennsylvania);  Louis D. Falo, JR. (Pittsburgh, Pennsylvania)
ABSTRACT The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX, PLS3, KIR3DL2, and/or GATA3 is associated with CTCL and decreased expression of RUNX3, relative to normal control, is associated with CTCL. One or more of these biomarkers may be used to diagnose CTCL and/or design and monitor treatment.
FILED Friday, June 18, 2021
APPL NO 17/351950
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/192 (20130101)
A61K 31/395 (20130101)
A61K 31/519 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/10 (20130101)
A61N 5/062 (20130101)
A61N 2005/0661 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)
C12N 2310/14 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101)
C12Q 2600/106 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57407 (20130101)
G01N 33/57426 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311063 Bigner et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S) Duke University (Durham, North Carolina)
INVENTOR(S) Darell D. Bigner (Mebane, North Carolina);  Vidyalakshmi Chandramohan (Durham, North Carolina);  Matthias Gromeier (Durham, North Carolina)
ABSTRACT A reliable assay to specifically detect CD155 in tissue sections has widespread use because CD155 is expressed widely among tumor types. Additionally, detected expression of CD 155 in glioblastoma cells is at levels commensurate with susceptibility to PVSRIPO (a poliovirus construct) infection and killing. An anti-CD155 antibody can achieve mono-specific detection of CD155 in immunoblots of tumor homogenates and immunohistochemistry of tumor formalin fixed, paraffin embedded sections. The assay can be used to determine appropriate use of PVSRIPO in oncolytic immunotherapy against cancers.
FILED Monday, October 02, 2017
APPL NO 16/340026
CURRENT CPC
Peptides
C07K 16/2896 (20130101)
C07K 2317/20 (20130101)
C07K 2317/34 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/60 (20130101)
G01N 33/582 (20130101)
G01N 33/57484 (20130101) Original (OR) Class
G01N 2333/908 (20130101)
G01N 2333/70596 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311066 ACKERSON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Colorado State University Research Foundation (Fort Collins, Colorado)
ASSIGNEE(S) Colorado State University Research Foundation (Fort Collins, Colorado)
INVENTOR(S) Christopher J. ACKERSON (Fort Collins, Colorado);  Zachary BUTZ (Fort Collins, Colorado);  Richard NEMETH (Fort Collins, Colorado);  Ryan RISKOWSKI (Fort Collins, Colorado);  Kanda BORGOGNONI (Fort Collins, Colorado)
ABSTRACT Enzymes that reduce specific metal or metalloid ions to insoluble form are important to science. Peptides isolated from yeast- and phage-display libraries can affect the size and morphology of inorganic materials during their synthesis. Herein, an Se binding peptide was fused to an enzyme capable of reducing selenite (SeO32−) to a Se0 nanoparticle (SeNP). The fusion of the Se binding peptide to the metalloid reductase provided size control of the resulting SeNP. The SeNP product also remains associated to the enzyme fusion. The Se binding peptide fusion to the enzyme increases the enzyme's SeO32− reductase activity. Modification of enzyme activity was absent, and the size control of particles was diminished when the Se binding peptide was added exogenously to the reaction mixture. Binding of the peptide is attributed to His based ligation that results in a conformational change to the peptide.
FILED Friday, August 09, 2019
APPL NO 17/266734
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/26 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/68 (20130101)
G01N 33/581 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311067 TONG
FUNDED BY
Department of Homeland Security (DHS)
Science and Technology Directorate (DHS-S&T)
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) SAN DIEGO STATE UNIVERSITY FOUNDATION (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) William G. TONG (La Jolla, California)
ABSTRACT This patent document discloses techniques, systems, and devices for detecting a target substance using optical nonlinear wave mixing for enhanced detection sensitivity and accuracy. In one aspect, a method for measuring α-synuclein in a body fluid of a patient with high detection sensitivity and accuracy and providing early stage Parkinson's disease detection is provided. The method may comprise: supplying to a capillary analyte cell a fluidic sample that includes a body fluid of a patient containing α-synuclein, wherein the capillary analyte cell is located in a nonlinear optical four-wave mixing device; directing laser light from the nonlinear optical four-wave mixing device into the capillary analyte cell to cause nonlinear optical four-wave mixing in the fluidic sample to generate a four-wave mixing signal that contains information on the α-synuclein in the fluidic sample; and processing the four-wave mixing signal to extract information on the α-synuclein in the fluidic sample.
FILED Tuesday, February 21, 2017
APPL NO 15/999856
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502715 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/03 (20130101)
G01N 21/636 (20130101)
G01N 21/718 (20130101)
G01N 27/44791 (20130101)
G01N 33/49 (20130101)
G01N 33/582 (20130101) Original (OR) Class
G01N 33/6896 (20130101)
G01N 2021/0346 (20130101)
G01N 2800/56 (20130101)
G01N 2800/2835 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311076 Kipnis et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S)
INVENTOR(S) Jonathan Kipnis (Charlottesville, Virginia);  Sandro Da Mesquita (Charlottesville, Virginia)
ABSTRACT In some embodiments herein, methods, compositions, and uses for countering the effects of aberrant meningeal lymphatic drainage and/or modulating lymphatic vessels of the central nervous system are described. In some embodiments, methods, compositions, or uses for treating, preventing, or ameliorating symptoms of a neurodegenerative disease associated with aberrant meningeal lymphatic drainage are described. Modulating lymphatic vessels, or countering the effects of aberrant meningeal lymphatic drainage, in accordance with some embodiments, are used to diagnose, treat, prevent, or ameliorate symptoms of neurodegenerative diseases such as Alzheimer's disease (AD) and dementia. Methods of diagnosing and monitoring the progression of neurological diseases are also provided.
FILED Monday, July 15, 2019
APPL NO 17/260023
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6896 (20130101) Original (OR) Class
G01N 2500/10 (20130101)
G01N 2800/50 (20130101)
G01N 2800/52 (20130101)
G01N 2800/60 (20130101)
G01N 2800/2821 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210312626 Griswold et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Mark A. Griswold (Shaker Heights, Ohio);  Dan Ma (Solon, Ohio);  Debra McGivney (Bay Village, Ohio);  Rasim Boyacioglu (Cleveland Heights, Ohio)
ABSTRACT A method for determining an undersampling error for a magnetic resonance fingerprinting (MRF) pulse sequence includes retrieving a plurality of sets of spatial response functions. Each set of spatial response functions is associated with a tissue type in a reference image and is based on a tissue mask of the reference image for each tissue type. A signal evolution for each tissue type may be generated based on, for example, the MRF pulse sequence, An undersampled image may be generated for each tissue type using the set of spatial response functions and the signal evolutions for the tissue type. At least one quantitative parameter may be determined by comparing an undersampled image series created from the undersampled images to an MRF dictionary. An undersampling error for the MRF pulse sequence may be generated by comparing a quantitative map (or maps) for the quantitative parameter (or parameters) and the reference image.
FILED Monday, April 05, 2021
APPL NO 17/301492
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/50 (20130101)
G01R 33/445 (20130101)
G01R 33/4625 (20130101)
G01R 33/4824 (20130101)
G01R 33/5608 (20130101)

Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 7/0014 (20130101) Original (OR) Class
G06T 2207/10088 (20130101)
G06T 2207/30016 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313040 MARGOLIN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Institute of Child Health and Human Development (NICHD)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
Directorate for Social, Behavioral and Economic Sciences (SBE)
Division of Behavioral and Cognitive Sciences (BCS)
APPLICANT(S) UNIVERSITY OF SOUTHERN CALIFORNIA (LOS ANGELES, California)
ASSIGNEE(S)
INVENTOR(S) GAYLA MARGOLIN (LOS ANGELES, California);  ADELA C. AHLE (SAN FRANCISCO, California);  MATTHEW WILLIAM AHLE (SAN FRANCISCO, California);  THEODORA CHASPARI (COLLEGE STATION, Texas);  SHRIKANTH SAMBASIVAN NARAYANAN (SANTA MONICA, California)
ABSTRACT A method for promoting interpersonal interactions includes a step of receiving data streams from a plurality of mobile smart devices from a plurality of users, the data streams recording information about users' daily lives. Intervention signals are sent to a user in response to data acquired from two or more individuals and interpreted with respect to user internal states, moods, emotions, predetermined behaviors, and interactions with other users.
FILED Friday, March 02, 2018
APPL NO 16/501128
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/021 (20130101)
A61B 5/165 (20130101)
A61B 5/486 (20130101)
A61B 5/7267 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 50/01 (20130101)

Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams
G09B 19/00 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/70 (20180101) Original (OR) Class
G16H 40/67 (20180101)
G16H 50/20 (20180101)
G16H 50/70 (20180101)

Telephonic Communication
H04M 1/725 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313065 LU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
National Library of Medicine (NLM)
APPLICANT(S) University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Qing LU (Gainesville, Florida);  Shan ZHANG (Gainesville, Florida);  Tingting HOU (Gainesville, Florida)
ABSTRACT Various examples of methods and systems are provided related to functional deep neural networks (FDNNs), which can be used for high dimensional data analysis. In one example, a FDNN can be trained with a training set of omic data to produce a trained FDNN model. The likelihood of a condition can be determined based upon output indications of the FDNN corresponding to the one or more phenotypes, with the output indications based upon analysis of omic data including a multi-level omic profile from an individual by the trained FDNN. The FDNN model can include a series of basis functions as layers to capture complexity between the omic data with disease phenotypes. A treatment or prevention strategy for the individual can be identified based at least in part upon the likelihood of the condition.
FILED Tuesday, March 30, 2021
APPL NO 17/217082
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/04 (20130101)
G06N 3/08 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30016 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 5/20 (20190201)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/60 (20180101)
G16H 30/40 (20180101)
G16H 50/20 (20180101) Original (OR) Class
G16H 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 20210307589 Rentschler et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of Colorado, a Body Corporate (Denver, Colorado)
ASSIGNEE(S) The Regents of the University of Colorado, a Body Corporate (Denver, Colorado)
INVENTOR(S) Mark E. Rentschler (Boulder, Colorado);  Steven A. Edmundowicz (Centennial, Colorado);  Karl Johannes (Boulder, Colorado)
ABSTRACT A medical device includes an elongate body and an inflatable balloon attached to and partially surrounding at least a section of the elongate body. The inflatable balloon is selectively inflatable between a deflated state and an inflated state. Engagement between the balloon and a physiological lumen is provided, in part, by multiple protrusions extending from the inflatable balloon and having various physical and functional characteristics. In certain implementations, the balloon may be configured to exhibit various separation forces by applying different strains to the balloon, such as by varying the degree to which the balloon is inflated or deflated.
FILED Tuesday, June 22, 2021
APPL NO 17/354090
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 1/00082 (20130101) Original (OR) Class
A61B 1/273 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 25/1002 (20130101)
A61M 25/1011 (20130101)
A61M 25/1029 (20130101)

Producing Particular Articles From Plastics or From Substances in a Plastic State
B29D 22/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307610 Tu et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Yanshuai Tu (Mesa, Arizona);  Yalin Wang (Tempe, Arizona);  Zhong-Lin Lu (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Yanshuai Tu (Mesa, Arizona);  Yalin Wang (Tempe, Arizona);  Zhong-Lin Lu (New York, New York)
ABSTRACT A sensory mapping method for a human brain is disclosed. The method includes the steps of flattening the cortical surface of the human brain, projecting functional imaging data onto the flattened surface, smoothing the functional imaging data, generating a sensory map, registering sensory maps across individuals and analyzing the maps in the common space. The flattening utilizes a conformal parametrization method. The smoothing utilizes a topological smoothing method that utilizes a diffeomorphic smoother. The registering is diffeomorphic. The sensory mapping method may further include a step of processing the functional imaging data to produce topological results.
FILED Friday, April 02, 2021
APPL NO 17/221507
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0042 (20130101) Original (OR) Class
A61B 5/055 (20130101)
A61B 2576/026 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/4806 (20130101)
G01R 33/5608 (20130101)

Image Data Processing or Generation, in General
G06T 3/0012 (20130101)
G06T 3/0031 (20130101)
G06T 3/0068 (20130101)
G06T 7/11 (20170101)
G06T 7/70 (20170101)
G06T 2207/10088 (20130101)
G06T 2207/30016 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307611 ZVIETCOVICH ZEGARRA et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S) University of Rochester (Rochester, New York)
ASSIGNEE(S) University of Rochester (Rochester, New York)
INVENTOR(S) Jose Fernando ZVIETCOVICH ZEGARRA (Houston, Texas);  Jannick P. Rolland (Rochester, New York);  Cristina Canavesi (West Henrietta, New York);  Kevin J. Parker (Rochester, New York)
ABSTRACT a) A Gabor domain optical coherence microscopy (GD-OCM) system providing high resolution of structural and motion imaging of objects such as tissues is combined with the use of reverberant shear wave fields (RevSW) or longitudinal shear waves (LSW) and two novel mechanical excitation sources: a coaxial coverslip excitation (CCE) and a multiple pronged excitation (MPE) sources providing structured and controlled mechanical excitation in tissues and leading to accurate derivation of elastographic properties. Alternatively, general optical computed tomography (OCT) is combined with RevSW or LWC in the object to derive elastographic properties. The embodiments include (a) GD-OCM with RevSW; (b) GD-OCM with LSW; (c) General OCT with RevSW; and General OCT with LSW.
FILED Thursday, April 02, 2020
APPL NO 16/838875
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0042 (20130101)
A61B 5/0051 (20130101)
A61B 5/0055 (20130101)
A61B 5/0066 (20130101) Original (OR) Class
A61B 5/0068 (20130101)
A61B 5/441 (20130101)
A61B 5/7257 (20130101)
A61B 2562/0242 (20130101)

Optical Elements, Systems, or Apparatus
G02B 6/4215 (20130101)
G02B 21/006 (20130101)
G02B 21/0028 (20130101)
G02B 21/0036 (20130101)
G02B 21/0076 (20130101)
G02B 21/365 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 2207/30016 (20130101)
G06T 2207/30041 (20130101)
G06T 2207/30088 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307677 Bi et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire);  CLEMSON UNIVERSITY (Clemson, South Carolina)
ASSIGNEE(S)
INVENTOR(S) Shengjie Bi (White River Junction, Vermont);  Tao Wang (White River Junction, Vermont);  Nicole Tobias (Williamston, South Carolina);  Josephine Nordrum (Hanover, New Hampshire);  Robert Halvorsen (Hanover, New Hampshire);  Ron Peterson (Brattleboro, Vermont);  Kelly Caine (Greenville, South Carolina);  Xing-Dong Yang (Hanover, New Hampshire);  Kofi Odame (Hanover, New Hampshire);  Ryan Halter (Lyme, New Hampshire);  Jacob Sorber (Clemson, South Carolina);  David Kotz (Lyme, New Hampshire)
ABSTRACT A wearable device for detecting eating episodes uses a contact microphone to provide audio signals through an analog front end to an analog-to-digital converter to digitize the audio and provide digitized audio to a processor; and a processor configured with firmware in a memory to extract features from the digitized audio. A classifier determines eating episodes from the extracted features. In embodiments, messages describing the detected eating episodes are transmitted to a cell phone, insulin pump, or camera configured to record video of the wearer's mouth.
FILED Wednesday, July 31, 2019
APPL NO 17/265032
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/725 (20130101)
A61B 5/1128 (20130101)
A61B 5/4542 (20130101) Original (OR) Class
A61B 5/6803 (20130101)
A61B 5/6898 (20130101)
A61B 5/7264 (20130101)
A61B 7/006 (20130101)
A61B 2560/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307817 HENDON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S)
INVENTOR(S) CHRISTINE HENDON (Bronx, New York);  RAJINDER SINGH-MOON (Mastic, New York);  XIN YU (Guangdong, China PRC)
ABSTRACT An exemplary system, method and computer-accessible medium for determining particular for a portion(s) of an organ of a patient(s) can be provided, which can include, for example, receiving an in vivo optical coherence tomography (OCT) imaging information for the portion(s), and determining (i) a lesion formation on or in the portion(s), (ii) a contact of a catheter on or with the portion(s), or (iii) an angle of the catheter with respect to the portion(s), by applying a convolutional neural network(s) to the in vivo OCT imaging information.
FILED Monday, March 29, 2021
APPL NO 17/215568
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 18/1492 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/0454 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 2207/10101 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30096 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308064 KONG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S) Hyunjoon KONG (Champaign, Illinois);  Yu-Tong HONG (Urbana, Illinois);  Yongbeom SEO (Woodbury, Minnesota)
ABSTRACT Provided herein are stimulus-responsive polymer microgelator particles that can activate fibrin fiber formation from their surfaces by actively ejecting thrombin to form an interconnected fibrin network with an increased elastic modulus and desirable microstructure. The use of the microgelators enables the decoupling of gelation rate and gel rigidity.
FILED Friday, April 02, 2021
APPL NO 17/221203
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101)
A61K 9/5031 (20130101) Original (OR) Class
A61K 38/363 (20130101)
A61K 38/4833 (20130101)
A61K 47/02 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 7/04 (20180101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 23/34 (20130101)
B01J 31/06 (20130101)
B01J 35/026 (20130101)
B01J 37/0072 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308065 Scott et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Allergy and Infectious Diseases (NIAID)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Evan A. Scott (Northfield, Illinois);  Sharan Bobbala (Evanston, Illinois);  Sean D. Allen (Evanston, Illinois)
ABSTRACT Provided herein are bicontinuous nanosphere nanocarrier that allow for slow, sustained release or allow for targeted release of target molecules. Further embodiments of the present invention provide bicontinuous nanosphere nanocarrier comprising a photosensitizer and a suitable polymer. Also provided are methods for making and using the photosensitive nanocarrier.
FILED Monday, April 05, 2021
APPL NO 17/301512
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/51 (20130101)
A61K 9/5031 (20130101) Original (OR) Class
A61K 31/20 (20130101)
A61K 31/4745 (20130101)
A61K 38/385 (20130101)
A61K 41/0071 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308215 Rivera-Feliciano et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Jose Rivera-Feliciano (Brookline, Massachusetts);  Edwin Rosado-Olivieri (Somerville, Massachusetts);  Douglas A. Melton (Lexington, Massachusetts)
ABSTRACT A previously uncharacterized gene and gene product are disclosed herein that increase blood glucose clearance independent of insulin. Also described is a methodology for enriching for mRNAs transcribing excreted and membrane bound proteins as well as a non-human animal expressing a labeled SEC61b protein.
FILED Monday, September 23, 2019
APPL NO 17/278644
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/1709 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/10 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308242 ZURAWSKI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Science Foundation (NSF)
APPLICANT(S) BAYLOR RESEARCH INSTITUTE (Dallas, Texas)
ASSIGNEE(S) BAYLOR RESEARCH INSTITUTE (Dallas, Texas)
INVENTOR(S) Gerard ZURAWSKI (Midlothian, Texas);  Jacques F. Banchereau (Montclair, New Jersey);  Anne-Laure FLAMAR (New York, New York);  Peter KLUCAR (Magnolia, Arkansas);  Keiko AKAGAWA (Dallas, Texas);  Sandra ZURAWSKI (Midlothian, Texas);  SangKon OH (Baltimore, Maryland)
ABSTRACT The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
FILED Monday, April 12, 2021
APPL NO 17/301704
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/001129 (20180801) Original (OR) Class
A61K 2039/6056 (20130101)

Peptides
C07K 14/435 (20130101)
C07K 16/2878 (20130101)
C07K 2319/00 (20130101)
C07K 2319/33 (20130101)
C07K 2319/91 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308270 ALABI et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Cornell University (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Christopher Akinleye ALABI (Ithaca, New York);  Ngoc Nhu PHAN (Ithaca, New York)
ABSTRACT The present disclosure provides oligoTEAs and methods of using the oligoTEAs. The oligoTEAs may be functionalized with one or more cargo group. The oligoTEAs may be made by iterative thiol-ene and Michael reactions. The oligoTEAs functionalized with one or more cargo group may be used to treat bacterial infections, cancers, viral infections, urinary tract infections, skin infections, cystic fibrosis, sepsis, fungal infections, or a combination thereof.
FILED Thursday, May 16, 2019
APPL NO 17/055960
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/54 (20170801)
A61K 47/59 (20170801) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308320 Davidson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Matthew Davidson (Philadelphia, Pennsylvania);  Jason Alan Burdick (Philadelphia, Pennsylvania)
ABSTRACT Provided is a multi-fiber system that undergoes new chemical bonds in response to mechanical manipulation and has self-adhesive properties based on specific chemical reactions.
FILED Monday, March 15, 2021
APPL NO 17/201446
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 24/08 (20130101) Original (OR) Class
A61L 24/0015 (20130101)

Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives
C09J 9/00 (20130101)
C09J 105/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308327 Kyriakides et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) YALE UNIVERSITY (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Themis Kyriakides (Branford, Connecticut);  Aaron Morris (Ann Arbor, Michigan)
ABSTRACT The present invention relates in part to compositions and methods for treating a wound, or location of interest, in mammal by administering a decellularized extracellular matrix (ECM) lacking thrombospondin-2 (TSP-2-null ECM). In certain embodiments, the invention provides an acellular composition comprising a decellularized TSP-2-null ECM. In certain embodiments, the invention provides a tunable hydrogel comprising a decellularized TSP-2-null ECM. The invention also provides, in certain embodiments, methods for accelerating cellular migration, methods for enhancing cellular invasion, methods for enhancing vascular growth and maturation of a region to be treated, and/or methods for enhancing a wound repair in a mammal in need thereof.
FILED Friday, October 19, 2018
APPL NO 16/757811
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101)
A61K 35/28 (20130101)
A61K 35/32 (20130101)
A61K 35/33 (20130101)
A61K 35/34 (20130101)
A61K 35/545 (20130101)
A61K 45/06 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/52 (20130101)
A61L 27/54 (20130101)
A61L 27/3633 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 17/02 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308341 Ware et al.
FUNDED BY
National Science Foundation (NSF)
U.S. State Government
State of Texas
Texas Department of Public Safety (TX-DPS)
Texas Fusion Center (TX-FUSION)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Taylor Ware (Austin, Texas);  Walter Voit (Austin, Texas)
ABSTRACT The invention discloses a method for adhering a metal layer to a polymer substrate and device manufacture therefrom. The metal layer is deposited on a sacrificial substrate of a mold to form part of an interior surface of the mold, and a solution of monomers is deposited on the metal layer. The monomers are then polymerized together to form the polymer substrate on the metal layer. Then the polymer substrate is removed from the mold such that the metal layer is removed from the mold and adhered to the polymer substrate.
FILED Monday, April 19, 2021
APPL NO 17/234152
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/24 (20210101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 31/14 (20130101) Original (OR) Class
A61L 31/048 (20130101)
A61L 31/088 (20130101)
A61L 2400/16 (20130101)
A61L 2420/02 (20130101)

Processes for Applying Fluent Materials to Surfaces, in General
B05D 3/002 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 7/0423 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308663 LEE et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Laboratory (LANL)
Los Alamos National Security, LLC (LANS)
National Science Foundation (NSF)
APPLICANT(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
ASSIGNEE(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
INVENTOR(S) Sangwoo LEE (Cohoes, New York);  Chulsung BAE (Cohoes, New York);  Musashi J. BRIEM (Troy, New York);  Sungmin PARK (Troy, New York)
ABSTRACT The anion exchange membranes exhibit enhanced chemical stability and ion conductivity when compared with traditional styrene-based alkaline anion exchange membranes. A copolymer backbone is polymerized from a reaction medium that includes a diphenylalkylene and an alkadiene. The copolymer includes a plurality of pendant phenyl groups. The diphenyl groups on the polymer backbone are functionalized with one or more haloalkylated precursor substrates. The terminal halide from the precursor substrate can then be substituted with a desired ionic group. The diphenylethylene-based alkaline anion exchange membranes lack the α-hydrogens sharing tertiary carbons with phenyl groups from polystyrene or styrene-based precursor polymers, resulting in higher chemical stability. The ionic groups are also apart from each other by about 3 to 6 carbons in the polymer backbone, enhancing ion conductivity. These membrane are advantageous for use in fuel cells, electrolyzers employing hydrogen, ion separations, etc.
FILED Tuesday, October 22, 2019
APPL NO 17/287639
CURRENT CPC
Separation
B01D 61/44 (20130101)
B01D 71/06 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 41/07 (20170101) Original (OR) Class
B01J 41/14 (20130101)
B01J 47/12 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/469 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 212/32 (20130101)
C08F 2810/00 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/2287 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308861 Zhang et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Wenlong Zhang (Chandler, Arizona);  Pham Huy Nguyen (Mesa, Arizona);  Zhi Qiao (Tempe, Arizona);  Sam Seidel (Scottsdale, Arizona);  Imran I. B. Mohd (Tempe, Arizona);  Sunny Amatya (Mesa, Arizona)
ASSIGNEE(S)
INVENTOR(S) Wenlong Zhang (Chandler, Arizona);  Pham Huy Nguyen (Mesa, Arizona);  Zhi Qiao (Tempe, Arizona);  Sam Seidel (Scottsdale, Arizona);  Imran I. B. Mohd (Tempe, Arizona);  Sunny Amatya (Mesa, Arizona)
ABSTRACT A soft continuum robotic module comprises a plurality of inflatable actuators disposed between plates. Via inflation or deflation of one or more of the actuators, the module may extend, contract, twist, bend, and/or exert a grasping force. One or more modules may be combined to form a robotic arm with multiple degrees of freedom.
FILED Wednesday, April 07, 2021
APPL NO 17/224809
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/142 (20130101) Original (OR) Class
B25J 9/1075 (20130101)
B25J 13/088 (20130101)
B25J 18/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309526 Lee et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Daeyeon Lee (Wynnewood, Pennsylvania);  R. Bharath Venkatesh (Philadelphia, Pennsylvania)
ABSTRACT Provided are methods for forming polymer-infiltrated nanoparticle films by using capillary action to draw mobile molecular chains into the pores of a bed of nanoparticles. The chains can spread across the entire bed of nanoparticles. The disclosed methods also provide the formation of patterned polymer-infiltrated nanoparticle film compositions, as well as laterally graded compositions and compositions that feature a polymer gradient through the composition's thickness. Articles can be formed that include a plurality of polymer types infiltrated into the bed of nanoparticles.
FILED Tuesday, April 06, 2021
APPL NO 17/223546
CURRENT CPC
Processes for Applying Fluent Materials to Surfaces, in General
B05D 1/286 (20130101)
B05D 3/007 (20130101)
B05D 5/00 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 33/149 (20130101) Original (OR) Class

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309724 Brown et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Elektrofi, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Paul Brown (Boston, Massachusetts);  Tyler L. Carter (Newburyport, Massachusetts);  Lyndon Fitzgerald Charles, JR. (Medford, Massachusetts);  Chase Spenser Coffman (Newton, Massachusetts);  Daniel Benjamin Dadon (East Boston, Massachusetts);  Lisa Liu (Somerville, Massachusetts);  Sadiqua Shadbar (Allston, Massachusetts);  Chaitanya Sudrik (Stoneham, Massachusetts);  Yi Tang (Medford, Massachusetts);  Shankul Vartak (Cambridge, Massachusetts)
ABSTRACT The present disclosure provides compositions and methods for treating a disease or condition in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a composition comprising a plurality of particles comprising at least one therapeutic biologic suspended in a pharmaceutically acceptable liquid carrier.
FILED Friday, June 18, 2021
APPL NO 17/351963
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Peptides
C07K 16/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309783 MATYJASZEWSKI et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Krzysztof MATYJASZEWSKI (Pittsburgh, Pennsylvania);  Guojun XIE (Newark, Delaware);  Michael R. MARTINEZ (Millbrae, California);  Thomas G. RIBELLI (State College, Pennsylvania)
ABSTRACT A method of carrying out an atom transfer radical polymerization wherein intermolecular crosslinking can occur includes controlling an amount of crosslinking by carrying out the reaction under conditions wherein catalytic radical termination is favored over radical termination.
FILED Saturday, June 01, 2019
APPL NO 17/059806
CURRENT CPC
Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 293/005 (20130101) Original (OR) Class
C08F 2438/01 (20130101)
C08F 2810/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309818 BAE et al.
FUNDED BY
Department of Energy (DOE)
National Science Foundation (NSF)
APPLICANT(S) Chulsung BAE (Cohoes, New York);  Chang Y. RYU (Loudonville, New York);  Ding TIAN (Troy, New York)
ASSIGNEE(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
INVENTOR(S) Chulsung BAE (Cohoes, New York);  Chang Y. RYU (Loudonville, New York);  Ding TIAN (Troy, New York)
ABSTRACT An anion exchange membrane is provided by converting carbon-carbon double bonds in the backbone of polystyrene-block-polybutadiene-block-polystyrene (SBS) into epoxide groups. Unmodified SBS is first partially hydrogenated to remove about 65% to about 90% of carbon-carbon double bonds. The remaining double bonds are then converted to epoxide groups to form an epoxidized SBS. UV-initiated ring opening reactions between the epoxidized SBS and haloalkyloxiranes are then employed to simultaneously functionalize and crosslink the epoxidized SBS. The halide groups in the crosslinked polymer network can be replaced via nucleophilic substitution to offer anion conductivity, e.g., via reaction with trimethylamine. Further ion exchange reactions can then be performed to make the membrane hydroxide conductive. The crosslinked membranes described herein exhibit a mechanical strength improvement of 200% compared to unmodified SBS, while maintaining high hydroxide conductivity. This synthetic platform is advantageous to provide mechanically robust anion exchange membranes for fuel cell applications.
FILED Tuesday, April 06, 2021
APPL NO 17/223544
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 41/14 (20130101)
B01J 47/12 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 293/00 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/2287 (20130101) Original (OR) Class
C08J 2309/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309858 Seo et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Dong-Kyun Seo (Chandler, Arizona);  Kamil Kaloush (Scottsdale, Arizona);  Alireza Samieadel (Tempe, Arizona);  Elham Fini (Phoenix, Arizona);  Shaojiang Chen (Mesa, Arizona)
ASSIGNEE(S)
INVENTOR(S) Dong-Kyun Seo (Chandler, Arizona);  Kamil Kaloush (Scottsdale, Arizona);  Alireza Samieadel (Tempe, Arizona);  Elham Fini (Phoenix, Arizona);  Shaojiang Chen (Mesa, Arizona)
ABSTRACT A modified bitumen includes bitumen and a bitumen modifier. The bitumen modifier includes composite particles. The composite particles include aluminosilicate nanostructures defining nanopores and micropores and paraffin wax adhered to surfaces of the aluminosilicate nanostructures. Modifying bitumen includes combining bitumen and the bitumen modifier.
FILED Thursday, April 01, 2021
APPL NO 17/220549
CURRENT CPC
Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/34 (20130101)
C08K 2201/011 (20130101)

Compositions of Macromolecular Compounds
C08L 91/06 (20130101)
C08L 95/00 (20130101) Original (OR) Class
C08L 2555/50 (20130101)
C08L 2555/72 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309869 Kulinsky et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Lawrence Kulinsky (Irvine, California);  Tuo Zhou (Irvine, California)
ABSTRACT Carbon nanotube (CNT) agglomerates can be aligned along the field lines between adjacent electrodes to form conductive bridges. The present invention is directed to a stepwise process of dielectrophoretic deposition of CNTs to form conducting bridges between adjacent electrodes spanning lengths over 50 microns. The CNT bridges are permanently secured using electrodeposition of the conducting polymer polypyrrole. Morphologies of the CNT bridges formed within a frequency range of 1 kHz and 10 MHz are employed and explained as a consequence of interplay between dielectrophoretic and electroosmotic forces. Postdeposition heat treatment increases conductivity of CNT bridges likely due to solvent evaporation and resulting surface tension inducing better contact between CNTs.
FILED Tuesday, April 06, 2021
APPL NO 17/223459
CURRENT CPC
Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 5/4476 (20130101) Original (OR) Class

Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor
C25D 13/12 (20130101)
C25D 13/22 (20130101)
C25D 17/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309908 Taha et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
National Science Foundation (NSF)
APPLICANT(S) UNM Rainforest Innovations (Albuquerque, New Mexico);  National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico);  Transpo Industries, Inc. (New Rochelle, New York)
ASSIGNEE(S) UNM Rainforest Innovations (Albuquerque, New Mexico);  National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico);  Transpo Industries, Inc. (New Rochelle, New York)
INVENTOR(S) Mahmoud Reda Taha (Albuquerque, New Mexico);  Michael S. Stenko (Albuquerque, New Mexico);  John Stormont (Albuquerque, New Mexico);  Edward N. Matteo (Albuquerque, New Mexico);  Moneeb Genedy (Albuquerque, New Mexico);  Thomas Dewers (Albuquerque, New Mexico)
ABSTRACT A method and sealant to seal microcracks as small as 50 μm by causing methyl methacrylate combined with one or more nanoparticles to flow into the microcrack to be sealed.
FILED Tuesday, June 15, 2021
APPL NO 17/348685
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 8/428 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 33/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309955 Skerlos et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Steven Skerlos (Ann Arbor, Michigan);  Lutgarde Raskin (Ann Arbor, Michigan);  Timothy Fairley (Ann Arbor, Michigan);  Nishant Jalgaonkar (Ann Arbor, Michigan)
ABSTRACT The disclosure relates to bioreactors, for example for biological treatment and, more specifically to bioreactor insert apparatus including biofilms and related methods. The bioreactor insert apparatus provides a means for circulation of reaction medium within the bioreactor, a biofilm support, and biological treatment of an inlet feed to the reactor/insert apparatus. The bioreactor insert apparatus has a high relative surface area for biofilm attachment and is capable of generating complex flow patterns and increasing treatment efficiency/biological conversion activity in a biologically-active reactor. The high surface area structure incorporates multiple biofilm support structures such as meshes at inlet and outlet portions of the structure. The biofilm support structures and biofilms thereon can increase overall reaction rate of the bioreactor and/or perform some solid/liquid separation in the treatment of the wastewater or other influent.
FILED Monday, September 30, 2019
APPL NO 17/277910
CURRENT CPC
Treatment of Water, Waste Water, Sewage, or Sludge
C02F 3/10 (20130101)
C02F 3/1268 (20130101)
C02F 3/2806 (20130101)
C02F 3/2853 (20130101)

Apparatus for Enzymology or Microbiology;
C12M 23/06 (20130101)
C12M 25/00 (20130101)
C12M 27/14 (20130101)
C12M 29/26 (20130101) Original (OR) Class
C12M 33/14 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 5/023 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309986 PEREZ-PINERA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of General Medical Sciences (NIGMS)
Non-Profit Organization (NPO)
American Heart Association (AHA)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S) Pablo PEREZ-PINERA (Urbana, Illinois);  Michael P. GAPINSKE (Urbana, Illinois);  Jackson Scott WINTER (Palatine, Illinois)
ABSTRACT The disclosure provides a versatile method termed CRISPR-SKIP that utilizes cytidine and/or adenine deaminase base editors to program exon skipping by mutating target DNA bases within splice acceptor sites and/or splice enhancer sites. Given its simplicity and precision, CRISPR-SKIP will be broadly applicable in gene therapy and synthetic biology
FILED Friday, July 19, 2019
APPL NO 17/260828
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)
A61P 43/00 (20180101)

Peptides
C07K 2319/80 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 9/78 (20130101) Original (OR) Class
C12N 15/11 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)

Enzymes
C12Y 305/04004 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310016 CORUZZI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Organismal Systems (IOS)
APPLICANT(S) New York University (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Gloria M. CORUZZI (New York, New York);  Matthew BROOKS (White Plains, New York);  Kranthi VARALA (West Lafayette, Indiana)
ABSTRACT Methods for increasing or decreasing Nitrogen (N) uptake/assimilation and/or usage in plants comprising over-expressing or repressing one or more transcription factors that have been identified by evaluating temoporal transcription of the TFs in response to N signaling and validated based on TF perturbation studies in plant cells and plants. Combinations of TFs may be used, where each TF may be independently induced or repressed to achieve a desired increase or decrease in N uptake/assimilation.
FILED Friday, June 22, 2018
APPL NO 16/625286
CURRENT CPC
Peptides
C07K 14/415 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/111 (20130101)
C12N 15/113 (20130101)
C12N 15/8241 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
C12N 2310/141 (20130101)
C12N 2320/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310046 Seelig et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Georg Seelig (Seattle, Washington);  Richard Muscat (Seattle, Washington);  Alexander B. Rosenberg (Seattle, Washington)
ABSTRACT Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
FILED Tuesday, December 15, 2020
APPL NO 17/122321
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101) Original (OR) Class
C12Q 1/6855 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310150 Ydstie et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
INVENTOR(S) B. Erik Ydstie (Pittsburgh, Pennsylvania);  Eyan Peter Noronha (Pittsburgh, Pennsylvania)
ABSTRACT A method of forming crystalline sheets using a Horizontal Ribbon Growth process, where the sheet of material formed in the process is withdrawn from a crucible in a specified manner to reduce instabilities in the process and to regulate crystal growth dynamics.
FILED Tuesday, August 06, 2019
APPL NO 17/266417
CURRENT CPC
Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor
C30B 13/14 (20130101)
C30B 13/16 (20130101)
C30B 13/28 (20130101) Original (OR) Class
C30B 29/20 (20130101)
C30B 29/36 (20130101)
C30B 29/42 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310263 Zhang et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Jiansong Zhang (Lafayette, Indiana);  Christopher M Lacny (Indian Head Park, Illinois);  Noah Reardon (Chicago, Illinois)
ABSTRACT An autonomous construction robotic system is disclosed which includes a processing unit, a robotic arm, the robotic arm is adapted to be coupled to a central attachment arm and thereby position the central attachment arm according to a plurality of degrees of freedom, a panel handling and fastening system, including a panel handling assembly coupled to the central attachment arm and adapted to pick and place a construction panel onto a framed structure within a construction zone, and a vision system adapted to provide visual information to the processing unit associated with the framed structure, wherein the processing unit processes the visual information to automatically determine placement position of the construction panel on the framed structure.
FILED Tuesday, April 06, 2021
APPL NO 17/223111
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/123 (20130101)
B25J 9/126 (20130101)
B25J 9/1676 (20130101)
B25J 9/1697 (20130101)
B25J 11/0055 (20130101)
B25J 13/085 (20130101)
B25J 15/0019 (20130101)
B25J 15/0616 (20130101)

Scaffolding; Forms; Shuttering; Building Implements or Aids, or Their Use; Handling Building Materials on the Site; Repairing, Breaking-up or Other Work on Existing Buildings
E04G 21/167 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310715 Goldfarbmuren et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Rebound Technologies, Inc. (Commerce City, Colorado)
ASSIGNEE(S)
INVENTOR(S) Russell Goldfarbmuren (Denver, Colorado);  Luke Erickson (Denver, Colorado);  Josh Nelson (West Lafayette, Indiana);  Chance Lord (Denver, Colorado)
ABSTRACT Solid production systems, devices, and methods utilizing oleophilic surfaces are provided in accordance with various embodiments. Some embodiments include a water tank used to store fresh water. Some embodiments include an emulsion tank that may include a set of auxiliary components that may be utilized to create and/or to pump an emulsion. This auxiliary equipment may include suction headers, ejectors, pumps, mechanical mixers, and/or hydrodynamic mixers, for example. Some embodiments include a heat exchanger that may produce a cold surface for ice formation. This surface may include an oleophilic surface that may produce an affinity for oils and/or other non-polar materials. Some embodiments include piping that may allow for the connection of the other components such that ice may be formed from a flow of water from the emulsion and the overflow may be returned to the emulsion tank. Ice making methods are also provided.
FILED Thursday, December 26, 2019
APPL NO 16/966542
CURRENT CPC
Producing, Working or Handling Ice
F25C 1/04 (20130101)
F25C 1/12 (20130101) Original (OR) Class
F25C 5/187 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310788 Zawadzki et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Robert J. Zawadzki (Sacramento, California);  Edward N. Pugh, JR. (Davis, California);  Pengfei Zhang (Davis, California)
ABSTRACT Systems, apparatus and methods that modulate the phase inside the imaging system pupil aperture with a segmented deformable mirror, spatial light modulator (SLM), or liquid deformable lens (LDL) to produce minor perturbations in the point spread function (PSF) and create un-correlated speckle patterns between B-scans.
FILED Thursday, February 04, 2021
APPL NO 17/168043
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 9/02082 (20130101) Original (OR) Class
G01B 9/02091 (20130101)

Image Data Processing or Generation, in General
G06T 7/248 (20170101)
G06T 2207/10101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310881 Diehn et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Prasidiux, LLC (Arlington, Virginia)
ASSIGNEE(S) Prasidiux, LLC (Arlington, Virginia)
INVENTOR(S) Kevin K. Diehn (Towson, Maryland);  Bani H. Cipriano (Rockville, Maryland);  Rel S. Ambrozy (Arlington, Virginia)
ABSTRACT A new and useful thermochromic liquid crystal Indicator is disclosed that provides an indication of the temperature of the Object to which the Indicator is attached, and is an improvement over the existing art for at least the fact that the impact of ambient air circulating around the Indicator and circulating the Object is reduced by several means, such as i) the use of a novel cap or housing to isolate the liquid crystal Structure from ambient air and from touching or ii) using a novel liquid crystal formulation that reduces the reaction time of the thermochromic liquid crystal contained in the Indicator to changing temperatures conveyed by the ambient air. The new and useful liquid crystal Indicator can also employ either a template or a colored filter as a mask that narrows the colors and narrows the range of temperatures indicated by the Indicator.
FILED Friday, June 18, 2021
APPL NO 17/351466
CURRENT CPC
Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for
G01K 1/08 (20130101)
G01K 11/12 (20130101)
G01K 11/165 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310916 Godfrin et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) NANOSOFT, LLC. (Coventry, Rhode Island)
ASSIGNEE(S)
INVENTOR(S) Michael Godfrin (Narragansett, Rhode Island);  Michael Franzblau (Scituate, Rhode Island)
ABSTRACT A method includes introducing a fluidic sample into the void volume and onto the surface of a porous material, bringing the porous material into contact with a hydrophilic substrate compatible with a cryogenic Transmission Electron Microscope, separating the porous material from the substrate, and transferring a portion of the sample from the porous material to the substrate between their contact and separation.
FILED Monday, June 14, 2021
APPL NO 17/346758
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/42 (20130101) Original (OR) Class
G01N 23/04 (20130101)
G01N 2223/102 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310928 Huang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
APPLICANT(S) Jie Huang (Rolla, Missouri);  Chen Zhu (Rolla, Missouri);  Rex E. Gerald, II (Willow Springs, Illinois)
ASSIGNEE(S) The Curators of the University of Missouri (Columbia, Missouri)
INVENTOR(S) Jie Huang (Rolla, Missouri);  Chen Zhu (Rolla, Missouri);  Rex E. Gerald, II (Willow Springs, Illinois)
ABSTRACT An open-ended hollow coaxial cable resonator probe configured to receive an aerosol sample for analysis. A metal post shorts the resonator's inner and outer conductors. A metal plate is spaced apart from an open end of the resonator by a dielectric layer that contains the received aerosol sample. Interrogator circuitry coupled to the resonator transmits an electromagnetic wave within the resonator and generates an electric field at the open end of the resonator. The interrogator circuitry is responsive to the generated electric field for determining a resonance frequency and an impedance of the resonator when the aerosol sample is present in the dielectric layer and is configured to identify virus particles in the aerosol sample as a function of the determined resonance frequency and impedance. A portable aerosol analyzer comprises the open-ended hollow coaxial cable resonator and a mouthpiece through which a subject expels a breath sample into the open end of the resonator. Antibodies tethered to high-permittivity nanoparticles attach to pathogens selectively, resulting in enhanced sensing with molecular-level specificity.
FILED Tuesday, March 23, 2021
APPL NO 17/209785
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/24 (20130101)
G01N 15/0618 (20130101)
G01N 15/0656 (20130101) Original (OR) Class
G01N 33/497 (20130101)
G01N 2001/245 (20130101)
G01N 2033/4975 (20130101)
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US 20210311045 Biris et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas)
ASSIGNEE(S)
INVENTOR(S) Alexandru S. Biris (Little Rock, Arkansas);  Zeid Nima (Little Rock, Arkansas)
ABSTRACT A nanoagent for detections and treatments of multiple targets of interest includes multiple types of nanocomposites, each type of nanocomposites comprising at least one nanostructure, each nanostructure having a core and a shell surrounding the core; a respective reporter assembled on the shell of each nanostructure; and a layer of a respective treating agent and a respective targeting agent conjugated to the respective reporter. In use, each type of nanocomposite targets to a respective target of interest according to the respective targeting agent and releases the respective treating agent and the nanostructure therein for therapeutic treatment of the respective target of interest, and the respective target of interest transmits at least one signature responsive to the respective reporter for detection of the respective target of interest.
FILED Thursday, April 22, 2021
APPL NO 17/237184
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0092 (20130101)
A61K 31/337 (20130101)
A61K 31/704 (20130101)
A61K 41/0052 (20130101)
A61K 47/6849 (20170801)
A61K 47/6923 (20170801)
A61K 49/0065 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 13/02 (20130101)
B01J 13/06 (20130101)
B01J 13/20 (20130101)
B01J 13/22 (20130101)

Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 15/02 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/531 (20130101)
G01N 33/553 (20130101) Original (OR) Class
G01N 33/57492 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 1/0054 (20130101)
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US 20210311067 TONG
FUNDED BY
Department of Homeland Security (DHS)
Science and Technology Directorate (DHS-S&T)
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) SAN DIEGO STATE UNIVERSITY FOUNDATION (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) William G. TONG (La Jolla, California)
ABSTRACT This patent document discloses techniques, systems, and devices for detecting a target substance using optical nonlinear wave mixing for enhanced detection sensitivity and accuracy. In one aspect, a method for measuring α-synuclein in a body fluid of a patient with high detection sensitivity and accuracy and providing early stage Parkinson's disease detection is provided. The method may comprise: supplying to a capillary analyte cell a fluidic sample that includes a body fluid of a patient containing α-synuclein, wherein the capillary analyte cell is located in a nonlinear optical four-wave mixing device; directing laser light from the nonlinear optical four-wave mixing device into the capillary analyte cell to cause nonlinear optical four-wave mixing in the fluidic sample to generate a four-wave mixing signal that contains information on the α-synuclein in the fluidic sample; and processing the four-wave mixing signal to extract information on the α-synuclein in the fluidic sample.
FILED Tuesday, February 21, 2017
APPL NO 15/999856
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502715 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/03 (20130101)
G01N 21/636 (20130101)
G01N 21/718 (20130101)
G01N 27/44791 (20130101)
G01N 33/49 (20130101)
G01N 33/582 (20130101) Original (OR) Class
G01N 33/6896 (20130101)
G01N 2021/0346 (20130101)
G01N 2800/56 (20130101)
G01N 2800/2835 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311101 Katti et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S) California Institute of Technology (Pasadena, California)
INVENTOR(S) Raj M. Katti (Pasadena, California);  Harpreet Singh Arora (Pasadena, California);  Keith C. Schwab (Pasadena, California);  Michael L. Roukes (Pasadena, California);  Stevan Nadj-Perge (Pasadena, California)
ABSTRACT A graphene-based broadband radiation sensor and methods for operation thereof are disclosed. The radiation sensor includes an electrical signal path for carrying electrical signals and one or more resonance structures connected to the electrical signal path. Each resonance structure includes a resonator having a resonant frequency. Each resonance structure also includes a graphene junction connected in series with the resonator, the graphene junction including a graphene layer and having an impedance that is dependent on a temperature of the graphene layer. Each resonance structure further includes a heating element that is thermally coupled to the graphene layer and is configured to receive an incident photon, where the temperature of the graphene layer increases in response to the heating element receiving the incident photon.
FILED Wednesday, March 03, 2021
APPL NO 17/191443
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 29/0878 (20130101) Original (OR) Class
G01R 31/2824 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/112 (20130101)
H01L 31/1013 (20130101)
H01L 31/02019 (20130101)
H01L 39/223 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311226 Liu et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
ASSIGNEE(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
INVENTOR(S) Shizhao Liu (Troy, New York);  Joel L. Plawsky (Albany, New York)
ABSTRACT A two dimensional (2D) photonic crystal (PhC) structure includes a substrate and a periodic grating structure formed on the substrate. The periodic grating structure includes a plurality of gratings having a grating period, a. Each pair of adjacent gratings is separated by air. Each grating has a grating width, d, and includes a plurality of alternating layers of a first material and a second material. The first material corresponds to a high index material. The second material corresponds to a low index material. A ratio of a first refractive index of the first material to a second refractive index of the second material is greater than or equal to two. Each first material layer has a first thickness, t1. Each second material layer has a second thickness, t2. The 2D PhC structure has a structure refractive index at or near zero for a range of frequencies.
FILED Thursday, August 01, 2019
APPL NO 17/265063
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 1/005 (20130101) Original (OR) Class
G02B 5/1857 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311258 Frish
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Science Foundation (NSF)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Harel Frish (Moshav Sede Moshe, Israel)
ABSTRACT A structure for coupling an optical signal between an integrated circuit photonic structure and an external optical fiber is disclosed as in a method of formation. The coupling structure is sloped relative to a horizontal surface of the photonic structure such that light entering or leaving the photonic structure is substantially normal to its upper surface.
FILED Monday, June 21, 2021
APPL NO 17/352745
CURRENT CPC
Producing Particular Articles From Plastics or From Substances in a Plastic State
B29D 11/00663 (20130101)

Optical Elements, Systems, or Apparatus
G02B 6/13 (20130101)
G02B 6/30 (20130101) Original (OR) Class
G02B 6/34 (20130101)
G02B 6/122 (20130101)
G02B 6/124 (20130101)
G02B 6/132 (20130101)
G02B 6/3628 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311370 Macdonald et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Physics (PHY)
APPLICANT(S) VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Janet E. Macdonald (Nashville, Tennessee);  Richard F. Haglund (Nashville, Tennessee);  Nathan James Spear (Nashville, Tennessee);  Kent A. Hallman (Nashville, Tennessee);  Summer L. Arrowood (Nashville, Tennessee);  Roderick B. Davidson, II (Nashville, Tennessee);  Emil A. Hernandez-Pagan (Nashville, Tennessee)
ABSTRACT The present disclosure provides for materials (e.g., films, mixtures, and colloidally suspended in solution) including two types of particles (e.g., nanoparticles) that exhibit harmonic surface plasmon resonances (SPR), where these are referred to as harmonically paired set of particles. The present disclosure provides for harmonically paired set of particles, where the particles are separated by a dielectric layer. The dielectric layer has a thickness such that direct electron transfer does not occur between the harmonically paired set of particles. The harmonically paired set of particles can be included in harmonically paired set of particle system or devices which can be a component in measurement systems or devices.
FILED Friday, April 02, 2021
APPL NO 17/221013
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 20/00 (20130101)

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/353 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311397 ZHENG et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Yuebing ZHENG (Austin, Texas);  Linhan LIN (Austin, Texas);  Jingang LI (Austin, Texas)
ABSTRACT Disclosed herein are methods for patterning two-dimensional atomic layer materials, the methods comprising: illuminating a first location of an optothermal substrate with electromagnetic radiation, wherein the optothermal substrate converts at least a portion of the electromagnetic radiation into thermal energy, and wherein the optothermal substrate is in thermal contact with a two-dimensional atomic layer material; thereby: generating an ablation region at a location of the two-dimensional atomic layer material proximate to the first location of the optothermal substrate, wherein at least a portion of the ablation region has a temperature sufficient to ablate at least a portion of the two-dimensional atomic layer material within the ablation region, thereby patterning the two-dimensional atomic layer material. Also disclosed herein are systems for performing the methods described herein, patterned two-dimensional atomic layer materials made by the methods described herein and methods of use thereof.
FILED Monday, July 22, 2019
APPL NO 17/262015
CURRENT CPC
Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor;
G03F 7/202 (20130101) Original (OR) Class
G03F 7/213 (20130101)
G03F 7/702 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210312298 Kim et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Hyung-il Kim (Minneapolis, Minnesota);  Ibrahim Ahmed (Minneapolis, Minnesota);  Po-wei Chiu (Minneapolis, Minnesota)
ABSTRACT Compute engine circuitry configured to represent a spin network mapping of a graph representing a combinatorial optimization problem includes a plurality of ring oscillator cells, each of which includes a ring oscillator having an oscillator output, at least one coupling block, and a read block. Each coupling block connects the ring oscillator of the cell to the ring oscillator of one of a plurality of neighboring cells to form a coupled ring oscillator. The read block generates a state output for each coupled ring oscillator that indicates whether the coupled ring oscillator is in one of a same-phase state, in which the connected ring oscillators oscillate in phase with each other, and an opposite-phase state, in which the connected ring oscillators oscillate in an opposite phase from each other. A controller is configured to output a total energy of the mapping based on the state outputs.
FILED Friday, March 26, 2021
APPL NO 17/213396
CURRENT CPC
Electric Digital Data Processing
G06F 17/11 (20130101)

Computer Systems Based on Specific Computational Models
G06N 5/003 (20130101) Original (OR) Class
G06N 5/04 (20130101)
G06N 10/00 (20190101)

Pulse Technique
H03K 3/0315 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210312710 Fathi et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Pointivo, Inc. (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Habib Fathi (Atlanta, Georgia);  Daniel L. Ciprari (Atlanta, Georgia);  Bradden J. Gross (Atlanta, Georgia)
ABSTRACT The inventions herein relate generally to improvements in the generation of wireframe renderings derived from 2D and/or 3D data that includes at least one structure of interest in a scene. Such wireframe renderings and similar formats can be used in, among other things, 2D/3D CAD drawings, designs, drafts, models, building information models, augmented reality or virtual reality, and the like. Measurements, dimensions, geometric information, and semantic information generated according to the inventive methods can be accurate in relation to the actual structures. The wireframe renderings can be generated from a combination of a plurality of 2D images and point clouds, processing of point clouds to generate virtual/synthetic views to be used with the point clouds, or from 2D image data that has been processed in a machine learning process to generate 3D data. In some aspects, the wireframe renderings are accurate in relation to the actual structure of interest, automatically generated, or both.
FILED Friday, June 18, 2021
APPL NO 17/351457
CURRENT CPC
Electric Digital Data Processing
G06F 30/13 (20200101)

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Image Data Processing or Generation, in General
G06T 17/05 (20130101)
G06T 17/20 (20130101) Original (OR) Class
G06T 2207/20081 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210312715 Ramani et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Undergraduate Education (DUE)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Office of Integrative Activities (OIA)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)
INVENTOR(S) Karthik Ramani (West Lafayette, Indiana);  Terrell Kendall Glenn (Sagamore Hills, Ohio);  Caleb Carithers (Greer, South Carolina);  Ananya Ipsita (Lafayette, Indiana)
ABSTRACT A unique storytelling system is disclosed herein in which a plug-and-play hardware platform with an integrated augmented reality (AR) environment brings stories to life. The storytelling system includes an electronics toolkit and a structure toolkit which enable the user to prototype interactive physical devices for storytelling. The interactive physical devices crafted by the user are easily programmed using a simple visual programing environment of the storytelling system. Additionally, a story event planning tool of the storytelling system enables the user to create customized interactions between the interactive physical devices and virtual AR objects, such as virtual AR avatars or the like. Finally, an AR storytelling application of the storytelling system utilizes an AR device, such as a smartphone, to bring the interactive physical devices to life and enable the user to tell stories using the custom interactions that he or she created.
FILED Tuesday, April 06, 2021
APPL NO 17/223287
CURRENT CPC
Electric Digital Data Processing
G06F 3/04815 (20130101)
G06F 8/34 (20130101)

Image Data Processing or Generation, in General
G06T 13/40 (20130101)
G06T 19/006 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313040 MARGOLIN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Institute of Child Health and Human Development (NICHD)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
Directorate for Social, Behavioral and Economic Sciences (SBE)
Division of Behavioral and Cognitive Sciences (BCS)
APPLICANT(S) UNIVERSITY OF SOUTHERN CALIFORNIA (LOS ANGELES, California)
ASSIGNEE(S)
INVENTOR(S) GAYLA MARGOLIN (LOS ANGELES, California);  ADELA C. AHLE (SAN FRANCISCO, California);  MATTHEW WILLIAM AHLE (SAN FRANCISCO, California);  THEODORA CHASPARI (COLLEGE STATION, Texas);  SHRIKANTH SAMBASIVAN NARAYANAN (SANTA MONICA, California)
ABSTRACT A method for promoting interpersonal interactions includes a step of receiving data streams from a plurality of mobile smart devices from a plurality of users, the data streams recording information about users' daily lives. Intervention signals are sent to a user in response to data acquired from two or more individuals and interpreted with respect to user internal states, moods, emotions, predetermined behaviors, and interactions with other users.
FILED Friday, March 02, 2018
APPL NO 16/501128
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/021 (20130101)
A61B 5/165 (20130101)
A61B 5/486 (20130101)
A61B 5/7267 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 50/01 (20130101)

Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams
G09B 19/00 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/70 (20180101) Original (OR) Class
G16H 40/67 (20180101)
G16H 50/20 (20180101)
G16H 50/70 (20180101)

Telephonic Communication
H04M 1/725 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313503 Patel et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Shrayesh N. Patel (Chicago, Illinois);  Tengzhou Ma (Chicago, Illinois);  William F. Kent (Chicago, Illinois);  Garrett K. Grocke (Chicago, Illinois)
ABSTRACT The present disclosure relates to functionally graded thermoelectric materials including an organic conducting polymer. In particular, the material includes a molecular dopant that can be spatially distributed in a controlled pattern within the material. Methods of making such materials and devices including such materials are also described herein.
FILED Thursday, April 01, 2021
APPL NO 17/301403
CURRENT CPC
Compositions of Macromolecular Compounds
C08L 65/00 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 35/24 (20130101) Original (OR) Class
H01L 35/32 (20130101)
H01L 35/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210314058 Lucia et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
ASSIGNEE(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
INVENTOR(S) Brandon Lucia (Pittsburgh, Pennsylvania);  Bradley Denby (Pittsburgh, Pennsylvania)
ABSTRACT A system and method of controlling a constellation of nanosatellites colocates processing resources with sensors in each satellite. Latencies in data transmission are addressed by organizing the constellation of satellites into computational pipelines. An orbital edge computing module simulates system design for mission design, planning and analysis in addition to supporting online autonomy.
FILED Thursday, April 01, 2021
APPL NO 17/220861
CURRENT CPC
Transmission
H04B 7/18513 (20130101) Original (OR) Class
H04B 7/18515 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 20210307422 Dion et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Picatinny Arsenal (PICA)
APPLICANT(S) Genevieve Dion (Philadelphia, Pennsylvania);  Richard J. Hamilton (Jenkintown, Pennsylvania);  Amy L. Stoltzfus (Kirkland, Washington);  Chelsea E. Amanatides (Philadelphia, Pennsylvania);  Keith Taylor (Philadelphia, Pennsylvania);  Leighton Cline (Philadelphia, Pennsylvania);  Sol Schade (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Genevieve Dion (Philadelphia, Pennsylvania);  Richard J. Hamilton (Jenkintown, Pennsylvania);  Amy L. Stoltzfus (Kirkland, Washington);  Chelsea E. Amanatides (Philadelphia, Pennsylvania);  Keith Taylor (Philadelphia, Pennsylvania);  Leighton Cline (Philadelphia, Pennsylvania);  Sol Schade (Philadelphia, Pennsylvania)
ABSTRACT A personal protective respirator comprising a facepiece housing configured to cover the nose and mouth and conform to a face of an intended wearer along a perimeter of the facepiece housing and at least two straps, wherein the facepiece housing and the straps consist of a knitted material and the facepiece housing conforms to the face of the intended wearer such that sufficient fit is achieved to attain a fit factor of at least 100 on the intended wearer according to OSHA fit testing procedures. Also, a personal protective respirator comprising a face portion configured to cover a nose and mouth of an intended wearer and to conform to a face of the intended wearer and at least four straps, wherein the mask meets NIOSH requirements for N95 respirator performance and maintains this level of performance after being washed. Finally, a method for making the noted personal protective respirators.
FILED Friday, April 02, 2021
APPL NO 17/221233
CURRENT CPC
Outerwear; Protective Garments; Accessories
A41D 13/1161 (20130101) Original (OR) Class
A41D 13/1192 (20130101)
A41D 2500/10 (20130101)

Devices, Apparatus or Methods for Life-saving
A62B 9/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307608 Hu et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Juejun Hu (Newton, Massachusetts);  Tian GU (Fairfax, Virginia);  Mikhail Shalaginov (Somerville, Massachusetts);  Fan YANG (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Juejun Hu (Newton, Massachusetts);  Tian GU (Fairfax, Virginia);  Mikhail Shalaginov (Somerville, Massachusetts);  Fan YANG (Cambridge, Massachusetts)
ABSTRACT Meta-lens based ocular imaging, near-eye display, and eye-tracking systems are described. The systems can include a single focusing optic and an integrated circuit that provides illumination light and includes an imaging array. The focusing optic includes meta-atoms formed on a substrate. The systems may have no moving parts and achieve imaging or image-projection fields-of-view approaching or exceeding 180 degrees. Because of their low part count, the systems can be robust and have a very small form factor.
FILED Monday, February 01, 2021
APPL NO 17/164425
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 3/12 (20130101)
A61B 3/14 (20130101) Original (OR) Class
A61B 3/113 (20130101)

Optical Elements, Systems, or Apparatus
G02B 1/002 (20130101)
G02B 27/0093 (20130101)
G02B 27/0172 (20130101)
G02B 2027/0123 (20130101)
G02B 2027/0147 (20130101)

Electric Digital Data Processing
G06F 3/013 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307642 Candell et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
Air Force Office of Scientific Research (AFOSR)
U.S. Air Force
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Lawrence M. Candell (Arlington, Massachusetts);  Christopher Ferraiolo (Newburyport, Massachusetts);  Gary A. Shaw (Westford, Massachusetts);  Andrew M. Siegel (Arlington, Massachusetts);  George Zogbi (Arlington, Massachusetts)
ABSTRACT Systems, apparatus, and methods related to modeling, monitoring, and/or managing metabolism of a subject include measuring a respiratory quotient (RQ) level in a subject and/or optimizing and executing a nonlinear feedback model to model energy substrate utilization in the subject based on at least one of a macronutrient composition and caloric value of food consumed by the subject, an intensity and duration of activity by the subject, a rate and maximum capacity of glycogen storage in the subject, a rate and maximum capacity of de novo lipogenesis in the subject, a quality and duration of sleep by the subject, and/or an RQ level in the subject.
FILED Thursday, January 07, 2021
APPL NO 17/143459
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/082 (20130101)
A61B 5/083 (20130101) Original (OR) Class
A61B 5/097 (20130101)
A61B 5/0816 (20130101)
A61B 5/0833 (20130101)
A61B 5/0836 (20130101)
A61B 5/0871 (20130101)
A61B 5/4866 (20130101)
A61B 5/7275 (20130101)
A61B 2560/0247 (20130101)

Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams
G09B 19/00 (20130101)
G09B 19/0092 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307644 Harshman et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Secretary of the Air Force (SECAF)
APPLICANT(S) Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S) Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
INVENTOR(S) Sean W. Harshman (Fairborn, Ohio);  Brian A. Geier (Fairborn, Ohio);  Claude C. Gigsby (Beavercreek, Ohio);  Jeffrey B. Phillips (Centerville, Ohio);  Darrin K. Ott (Waynesville, Ohio)
ABSTRACT A method of detecting hypoxia. Detecting hypoxia includes detecting, in exhaled breath, at least one indicator for hypoxia. The at least one indicator is selected from the group consisting of pentanal, 2-pentanone, 2-hexanone, 2-heptanone, 2-cyclopenten-1-one, and 4-butyrolactone.
FILED Thursday, June 17, 2021
APPL NO 17/350654
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/087 (20130101)
A61B 5/0833 (20130101) Original (OR) Class
A61B 5/0836 (20130101)
A61B 2010/0087 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 16/10 (20130101)
A61M 16/024 (20170801)

Devices, Apparatus or Methods for Life-saving
A62B 7/14 (20130101)
A62B 9/006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307753 DEISTER
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Axogen Corporation (Alachua, Florida)
ASSIGNEE(S) Axogen Corporation (Alachua, Florida)
INVENTOR(S) Curt DEISTER (Alachua, Florida)
ABSTRACT The problem of positioning one or more nerve ends inside a sheathing implant is solved by the use of a pulley and cinching systems that pull a nerve end into an implant and that can adjust the diameter of an implant to conform the implant to the diameter of the nerve, respectively. The pulley system utilizes a suture that traverses the wall of an implant leaving one end outside the implant wall and another end that can be attached to a nerve. Pulling the suture end outside the wall pulls the nerve attached to the other end of the suture into the bore of the implant. A cinching system utilizes specially arranged sutures within the wall of an implant to tighten or cinch up the wall after a nerve is placed therein, so as to conform at least part of the implant to the diameter of the nerve. Methods are also disclosed by which such pulley systems can be formed during an intraoperative procedure.
FILED Wednesday, January 27, 2021
APPL NO 17/159460
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 17/0466 (20130101)
A61B 17/0487 (20130101)
A61B 17/1128 (20130101) Original (OR) Class
A61B 2017/0417 (20130101)
A61B 2017/0475 (20130101)
A61B 2017/0477 (20130101)
A61B 2017/0496 (20130101)
A61B 2017/1132 (20130101)
A61B 2017/1142 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210307813 Farritor et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Telemedicine and Advanced Technology Research Center (TATRC)
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Board of Regents of the University of Nebraska (Lincoln, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Shane Farritor (Lincoln, Nebraska);  Thomas Frederick (Gretna, Nebraska);  Joe Bartels (Pittsburgh, Pennsylvania)
ABSTRACT The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector.
FILED Monday, June 21, 2021
APPL NO 17/352817
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 18/1445 (20130101) Original (OR) Class
A61B 2034/301 (20160201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308168 PAINTER et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) EMORY UNIVERSITY (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) George R. PAINTER (Atlanta, Georgia);  David PERRYMAN (Decatur, Georgia);  Gregory R. BLUEMLING (Decatur, Georgia)
ABSTRACT Disclosed are halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections. Such viral infections can include tongaviridae, bunyaviridae, arenaviridae, coronaviridae, flaviviridae, picornaviridae, Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infections.
FILED Thursday, March 07, 2019
APPL NO 16/979108
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/008 (20130101)
A61K 31/7068 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308195 Danino et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Tal Danino (New York, New York);  Nicholas Arpaia (New York, New York);  Sreyan Chowdhury (New York, New York);  Candice Gurbatri (New York, New York)
ABSTRACT Disclosed herein are programmable bacteria for tumor-targeted immunotherapeutic delivery. In certain embodiments, the programmable bacteria comprise at least one synchronized lysis circuit contained in a single operon which are capable of being further engineered to cyclically produce anti-cancer therapeutic agents including but not limited to nanobodies against immune checkpoint inhibitors and over-expressed markers in cancers, toxins, tumor antigens, cytokines, and chemokines. In some embodiments, the programmable bacteria comprise at least one synchronized lysis circuit contained in a single operon and at least one plasmid producing a therapeutic agent, i.e., at least one plasmid comprising a nucleic acid sequence which encodes a therapeutic agent. The disclosure also provides methods of curing and treating cancer using the programmable bacteria.
FILED Wednesday, January 20, 2021
APPL NO 17/152893
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/74 (20130101) Original (OR) Class
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/195 (20130101)
C07K 14/521 (20130101)
C07K 16/2803 (20130101)
C07K 16/2818 (20130101)
C07K 16/2827 (20130101)
C07K 16/2896 (20130101)
C07K 2317/569 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308210 Aldrich et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) University of Kansas (Lawrence, Kansas);  University of Florida Research Foundation (Gainsville, Florida)
ASSIGNEE(S)
INVENTOR(S) Jane Aldrich (Gainsville, Florida);  Archana Mukhopadhyay (Cranbury, New Jersey);  Laura E. Hanold (Gainsville, Florida)
ABSTRACT The present technology provides methods end medicaments useful for treating prostate cancer and breast cancer. Such methods include administering at least one of cyclo[Phe-D-Pro-Phe-Trp] and cyclo[Phe-D-Pro-Phe-D-Trp] to a subject suffering from prostate cancer or breast cancer.
FILED Friday, October 16, 2020
APPL NO 17/072409
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/08 (20130101)
A61K 9/0019 (20130101)
A61K 9/0029 (20130101)
A61K 9/0053 (20130101)
A61K 38/12 (20130101) Original (OR) Class
A61K 47/02 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308468 Shepard et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (, None)
INVENTOR(S) Kenneth L. Shepard (Ossining, New York);  David Tsai (New York, New York);  Hongki Kang (South Korea, South Korea);  Jordan Thimot (New York, New York)
ABSTRACT Systems and methods for providing neural stimulation and recording on a subject using flexible complementary CMOS probes are provided. Disclosed systems can include a flexible probe adapted for insertion into a portion of a brain of the subject, the flexible probe comprising a tail portion and a head portion. The tail portion can include a plurality of electrodes configured to be coupled to the brain and a plurality of front-end amplifiers. Each of the plurality of front-end amplifiers can be configured to amplify a signal received from a corresponding electrode of the plurality of electrodes. The head portion can include one or more inductors configured to enable two-way communication with a wireless reader through a near-field inductive link.
FILED Monday, October 12, 2020
APPL NO 17/068229
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0031 (20130101)
A61B 5/291 (20210101)
A61B 5/7225 (20130101)
A61B 2560/0219 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/0529 (20130101)
A61N 1/0531 (20130101)
A61N 1/0551 (20130101)
A61N 1/3787 (20130101)
A61N 1/37223 (20130101) Original (OR) Class

Transmission
H04B 5/0081 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309391 Morrison
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) Matthew Morrison (Leonardtown, Maryland)
ASSIGNEE(S) United States of America as represented by the Secretary of the Navy (Patuxent River, Maryland)
INVENTOR(S) Matthew Morrison (Leonardtown, Maryland)
ABSTRACT An arm removal system for removing an arm. The system includes an anvil, and a removal assembly with at least two jackscrews. The arm has an extension radially extending from the arm and an arm outer surface. The arm is disposed within a wedge shaped collet that is disposed within a socket in an aircraft with an aircraft outer surface. The removal assembly includes an extension engaging surface and threaded jackscrew holes for accepting the jackscrews, such that when the jackscrews are tightened within the jackscrew holes, the jackscrews apply force on the anvil and the aircraft outer surface in the direction away from the removal assembly such that the arm is eventually removed entirely from the aircraft.
FILED Tuesday, April 07, 2020
APPL NO 16/842165
CURRENT CPC
Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools
B23P 19/025 (20130101)

Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for
B64F 5/50 (20170101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309729 Cukierman et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
U.S. Army Medical Research and Development Command (USAMRDC)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Institute For Cancer Research d/b/a The Research Institute of Fox ChaseCancer Center (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Edna Cukierman (Philadelphia, Pennsylvania);  Ralph Francescone (Philadelphia, Pennsylvania);  Janusz Franco-Barraza (Philadelphia, Pennsylvania);  Kristopher Raghavan (Philadelphia, Pennsylvania)
ABSTRACT The present disclosure provides methods of inducing desmoplastic stroma to express a normal phenotype by detecting increased levels of NetG1 or NGL1 in tumor or in desmoplastic stroma isolated from a human subject, and/or detecting NetG1 in circulating extracellular vesicles, and/or detecting increased pFAK in the stroma, and treating the human subject with a therapeutic regimen; and by detecting NetG1 in a microvesicle isolated from a human subject, and/or treating the human subject with a therapeutic regimen.
FILED Tuesday, October 09, 2018
APPL NO 16/754877
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/217 (20130101)

Peptides
C07K 16/22 (20130101) Original (OR) Class
C07K 16/2818 (20130101)
C07K 16/2827 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57484 (20130101)
G01N 2800/7028 (20130101)
G01N 2800/7052 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309925 Vam
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
APPLICANT(S) University of Dayton (Dayton, Ohio)
ASSIGNEE(S)
INVENTOR(S) Albert S. Vam (Dayton, Ohio)
ABSTRACT A desulfurization system has an oxidation process unit, and a multi-stage, liquid-liquid extraction unit in series with the oxidation process unit. The multi-stage, liquid-liquid extraction unit spits a fuel input from the oxidation process unit into a desulfurized fuel that is output for use, and a by-product. A solvent/sulfur/hydrocarbon separation process unit receives the by-product from the multi-stage, liquid-liquid extraction unit.
FILED Monday, March 15, 2021
APPL NO 17/201903
CURRENT CPC
Separation
B01D 3/14 (20130101)
B01D 11/0492 (20130101)
B01D 17/02 (20130101)
B01D 61/16 (20130101)
B01D 2311/2634 (20130101)
B01D 2311/2669 (20130101)
B01D 2311/2696 (20130101)
B01D 2325/38 (20130101)

Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes
C10G 21/16 (20130101)
C10G 21/28 (20130101)
C10G 27/04 (20130101)
C10G 53/14 (20130101) Original (OR) Class
C10G 2300/202 (20130101)
C10G 2300/4081 (20130101)
C10G 2400/04 (20130101)
C10G 2400/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310162 Tibbits et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Picatinny Arsenal (PICA)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Ministry of Supply Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Skylar J.E. Tibbits (Boston, Massachusetts);  Jared Smith Laucks (Somerville, Massachusetts);  Schendy G. Kernizan (Milton, Massachusetts);  Lavender Rose Tessmer (Cambridge, Massachusetts);  Carmel Marie Dunlap (Somerville, Massachusetts);  Gihan S. Amarasiriwardena (Somerville, Massachusetts)
ABSTRACT Textiles formed of active and inactive materials are disclosed. The active and inactive materials are knit together so that the textile exhibits a predetermined shape change upon exposure to an external stimulus, such as heat or moisture.
FILED Friday, October 18, 2019
APPL NO 17/280040
CURRENT CPC
Woven Fabrics; Methods of Weaving; Looms
D03D 15/567 (20210101) Original (OR) Class

Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles
D10B 2201/10 (20130101)
D10B 2211/02 (20130101)
D10B 2211/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310503 Heisser et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Cornell University (Ithaca, New York)
ASSIGNEE(S)
INVENTOR(S) Ronald Heisser (Ithaca, New York);  Robert Shepherd (Ithaca, New York);  Cameron Aubin (Ithaca, New York)
ABSTRACT Disclosed herein are actuators and methods of making and actuating the same. Such actuators may comprise a body having a cavity, a membrane configured to cooperate with the cavity to form a combustion chamber, an inlet channel in fluid communication with the combustion chamber, an ignitor operable to ignite a combustible gas contained within the combustion chamber, and an outlet channel in fluid communication with the combustion chamber. The membrane may be configured to move in response to a change in pressure within the combustion chamber.
FILED Wednesday, August 19, 2020
APPL NO 16/997929
CURRENT CPC
Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for
F15B 15/10 (20130101) Original (OR) Class
F15B 15/19 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310771 Ramsey et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)
INVENTOR(S) Scott Ramsey (Fredericksburg, Virginia);  Troy Mayo (District Heights, Maryland);  Sam Lambrakos (Alexandria, Virginia)
ABSTRACT A method of evaluating camouflage for a specified area of responsibility, the method includes calculating an apparent spectrum of the camouflage at far field with respect to an observer; calculating an apparent spectrum of the specified area of responsibility at far field with respect to the observer; calculating a difference between the apparent spectrum of the camouflage with the apparent spectrum of the area of responsibility; and comparing the difference to a predetermined threshold, thereby determining suitability of the camouflage for the specified area of responsibility.
FILED Thursday, October 26, 2017
APPL NO 15/794903
CURRENT CPC
Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General
F41H 3/02 (20130101) Original (OR) Class

Image Data Processing or Generation, in General
G06T 11/001 (20130101)
G06T 2207/20024 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310774 Murphy
FUNDED BY
Department of Defense (DOD)
DOD Ordnance Technology Consortium (DOTC)
APPLICANT(S) Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Timothy A. Murphy (Tucson, Arizona)
ABSTRACT A projectile and deployment method ensures successful deployment of the projectile regardless of an external environment. Contacting engagement is maintained between a piston and deployable fins as the fins rotate from a folded position to a deployed position. The fins are pushed by the piston to rotate into a deployed position in which the fins are locked before the piston is able to eject from the assembly. Using the engaging tabs between the fins and the piston, and a modular pressure reservoir, the piston continues to push on the fins at least until the fins are deployed and locked. After locking, pressure in the projectile is equalized and the piston is launched off of the pressure reservoir. If the fins are not immediately deployed and locked, the piston will continue to push on the fins until the external environment enables full deployment or until the pressure is equalized.
FILED Monday, April 06, 2020
APPL NO 16/840817
CURRENT CPC
Explosive Charges, e.g for Blasting, Fireworks, Ammunition
F42B 10/20 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310898 Kuznia et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Ultra Communications, Inc. (Vista, California)
ASSIGNEE(S)
INVENTOR(S) Charles B. Kuznia (Encinitas, California);  Joseph Farzin Ahadian (San Marcos, California);  Sandra Skendzic (Vista, California)
ABSTRACT Methods and devices for coupling light bidirectionally into optical fiber are described. The disclosed devices can be manufactured inexpensively in one-piece and integrated in high speed optical transceivers with small form-factor. The described methods and devices enable OTDR functionality in such transceivers and are compatible with sensor components mounted on a wiring or circuit board.
FILED Wednesday, January 20, 2021
APPL NO 17/153432
CURRENT CPC
Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for
G01M 11/3154 (20130101) Original (OR) Class

Optical Elements, Systems, or Apparatus
G02B 6/4214 (20130101)
G02B 6/4246 (20130101)

Transmission
H04B 10/071 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310952 Ancona et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
Department of the Navy (DON)
Naval Research Laboratory (NRL)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)
INVENTOR(S) Mario Ancona (Alexandria, Virginia);  Hieu Bui (Alexandria, Virginia)
ABSTRACT The stiffness and topology of ultra-small circular DNAs and DNA/peptide hybrids are exploited to create a transducer of enzyme activity with low error rates. The modularity and flexibility of the concept are illustrated by demonstrating various transducers that respond to either specific restriction endonucleases or to specific proteases. In all cases the output is a DNA oligo signal that, as we show, can readily be converted directly to an optical readout, or can serve as input for further processing, for example, using DNA logic or amplification. By exploiting the DNA hairpin (or stem-loop) structure and the phenomenon of strand displacement, an enzyme signal is converted into a DNA signal, in the manner of a transducer. This is valuable because a DNA signal can be readily amplified, combined, and processed as information.
FILED Wednesday, June 16, 2021
APPL NO 17/348819
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/005 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6428 (20130101) Original (OR) Class
G01N 33/52 (20130101)
G01N 33/542 (20130101)
G01N 2021/6432 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310970 NOLAN et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) GARRY P. NOLAN (Redwood City, California);  Sean C. Bendall (San Mateo, California);  Robert M. Angelo (Menlo Park, California)
ABSTRACT A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.
FILED Tuesday, October 06, 2020
APPL NO 17/064311
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 23/2258 (20130101) Original (OR) Class
G01N 33/4833 (20130101)
G01N 33/5005 (20130101)
G01N 33/5008 (20130101)
G01N 33/6848 (20130101)
G01N 2458/15 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 49/14 (20130101)
H01J 49/0036 (20130101)
H01J 49/142 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310971 Mirica et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
APPLICANT(S) Trustees of Dartmouth College (Hanover, New Hampshire)
ASSIGNEE(S) Trustees of Dartmouth College (Hanover, New Hampshire)
INVENTOR(S) Katherine A. Mirica (Hanover, New Hampshire);  Zheng Meng (West Lebanon, New Hampshire);  Aylin Aykanat (Norwich, Vermont)
ABSTRACT In some embodiments, the present disclosure pertains to a bimetallic metal-organic framework. In some embodiments, the bimetallic metal-organic framework includes a plurality of first metals and a plurality of metal-containing ligands, where each metal-containing ligand includes a second metal and a ligand. In some embodiments, the ligand is coordinated with the second metal and at least one first metal. In some embodiments, the present disclosure pertains to a method of detecting an analyte in a sample by associating the sample with a bimetallic metal-organic framework, as disclosed herein, detecting a change in a property of the bimetallic metal-organic framework, and correlating the change in the property of the bimetallic metal-organic framework to the presence or absence of the analyte in the sample. In some embodiments, the present disclosure pertains to a method of making the bimetallic metal-organic frameworks disclosed herein.
FILED Monday, August 19, 2019
APPL NO 17/268996
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/126 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311025 Liu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Fei Liu (Mountain View, California);  Utkan Demirci (Stanford, California);  Sanjiv Sam Gambhir (Stanford, California);  Viswam S. Nair (Tampa, Florida)
ABSTRACT A device (“the ExoTIC device”) for the isolation of extracellular vesicles from an extracellular vesicle-containing sample in which the sample is flowed through a membrane in a flow chamber to capture and purify the extracellular vesicles on the membrane. The extracellular vesicles may be washed and collected and utilized in any one of a number of ways including, but not limited to, identifying biomarkers of a disease, identifying the presence of a biomarker in a patient to determine whether a patient has a disease, and therapeutically treating existing diseases by re-introducing the extracellular vesicles, potentially modified, back into a body.
FILED Friday, June 11, 2021
APPL NO 17/345968
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/50273 (20130101)
B01L 3/502715 (20130101)
B01L 3/502761 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/50 (20130101)
G01N 33/5005 (20130101)
G01N 33/5091 (20130101) Original (OR) Class
G01N 33/5308 (20130101)
G01N 2800/52 (20130101)
G01N 2800/56 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311067 TONG
FUNDED BY
Department of Homeland Security (DHS)
Science and Technology Directorate (DHS-S&T)
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) SAN DIEGO STATE UNIVERSITY FOUNDATION (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) William G. TONG (La Jolla, California)
ABSTRACT This patent document discloses techniques, systems, and devices for detecting a target substance using optical nonlinear wave mixing for enhanced detection sensitivity and accuracy. In one aspect, a method for measuring α-synuclein in a body fluid of a patient with high detection sensitivity and accuracy and providing early stage Parkinson's disease detection is provided. The method may comprise: supplying to a capillary analyte cell a fluidic sample that includes a body fluid of a patient containing α-synuclein, wherein the capillary analyte cell is located in a nonlinear optical four-wave mixing device; directing laser light from the nonlinear optical four-wave mixing device into the capillary analyte cell to cause nonlinear optical four-wave mixing in the fluidic sample to generate a four-wave mixing signal that contains information on the α-synuclein in the fluidic sample; and processing the four-wave mixing signal to extract information on the α-synuclein in the fluidic sample.
FILED Tuesday, February 21, 2017
APPL NO 15/999856
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502715 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/03 (20130101)
G01N 21/636 (20130101)
G01N 21/718 (20130101)
G01N 27/44791 (20130101)
G01N 33/49 (20130101)
G01N 33/582 (20130101) Original (OR) Class
G01N 33/6896 (20130101)
G01N 2021/0346 (20130101)
G01N 2800/56 (20130101)
G01N 2800/2835 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311113 Barrett
FUNDED BY
Department of Defense (DOD)
DOD Ordnance Technology Consortium (DOTC)
APPLICANT(S) Science Applications International Corporation (Reston, Virginia)
ASSIGNEE(S)
INVENTOR(S) David Michael Barrett (Burtonsville, Maryland)
ABSTRACT Systems, methods, and apparatuses are described for verifying the authenticity of an integrated circuit device. An integrated test apparatus may use quiescent current and/or conducted electromagnetic interference readings to determine if a device under test matches the characteristics of an authenticated device. Deviations from the characteristics of the authenticated device may be indicative of a counterfeit device.
FILED Monday, June 14, 2021
APPL NO 17/347042
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/3008 (20130101) Original (OR) Class
G01R 31/31905 (20130101)
G01R 31/318588 (20130101)

Electric Digital Data Processing
G06F 21/44 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311195 Mahajan et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Modular Optical Aperture Building Blocks (MOABB)
APPLICANT(S) Teledyne Scientific and Imaging, LLC (Thousand Oaks, California)
ASSIGNEE(S)
INVENTOR(S) Milind Mahajan (Thousand Oaks, California);  Weiya Zhang (Thousand Oaks, California);  Mark Anderson (Chapel Hill, North Carolina);  Mario Aguilar-Simon (Chapel Hill, North Carolina);  Brian Gregory (Newbury Park, California)
ABSTRACT A vision-cued random-access LIDAR system and method which determines the location and/or navigation path of a moving platform. A vision system on a moving platform identifies a region of interest. The system classifies objects within the region of interest, and directs random-access LIDAR to ping one or more of the classified objects. The platform is located in three dimensions using data from the vision system and LIDAR. The steps of classifying, directing, and locating are preferably performed continuously while the platform is moving and/or the vision system's field-of-view (FOV) is changing. Objects are preferably classified using at least one smart-vision algorithm, such as a machine-learning algorithm.
FILED Tuesday, April 07, 2020
APPL NO 16/842697
CURRENT CPC
Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit
B60W 30/095 (20130101)
B60W 2420/52 (20130101)

Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 7/4817 (20130101)
G01S 17/58 (20130101)
G01S 17/89 (20130101)
G01S 17/931 (20200101) Original (OR) Class
G01S 19/01 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311258 Frish
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Science Foundation (NSF)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Harel Frish (Moshav Sede Moshe, Israel)
ABSTRACT A structure for coupling an optical signal between an integrated circuit photonic structure and an external optical fiber is disclosed as in a method of formation. The coupling structure is sloped relative to a horizontal surface of the photonic structure such that light entering or leaving the photonic structure is substantially normal to its upper surface.
FILED Monday, June 21, 2021
APPL NO 17/352745
CURRENT CPC
Producing Particular Articles From Plastics or From Substances in a Plastic State
B29D 11/00663 (20130101)

Optical Elements, Systems, or Apparatus
G02B 6/13 (20130101)
G02B 6/30 (20130101) Original (OR) Class
G02B 6/34 (20130101)
G02B 6/122 (20130101)
G02B 6/124 (20130101)
G02B 6/132 (20130101)
G02B 6/3628 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311369 McManamon et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
United States Air Force (USAF)
APPLICANT(S) Exciting Technology, LLC (Dayton, Ohio)
ASSIGNEE(S)
INVENTOR(S) Paul F. McManamon (Dayton, Ohio);  Abtin Ataei (Oakwood, Ohio)
ABSTRACT An example system includes a high-side electrode layer including a number of discrete electrodes and a low-side electrode layer. The system further includes an electro-optic (EO) layer including an EO active material positioned between the high-side electrode layer and the low-side electrode layer, thereby forming a number of active cells of the EO layer. Each of the number of active cells of the EO layer includes a portion of the EO layer that is positioned between one of the discrete electrodes and the low-side electrode layer. The example system further includes an insulator operationally coupled to the active cells of the EO layer, and at least partially positioned between a first one of the active cells and a second one of the active cells.
FILED Friday, April 30, 2021
APPL NO 17/245532
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/139 (20130101)
G02F 1/311 (20210101)
G02F 1/3133 (20130101) Original (OR) Class
G02F 1/3138 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311397 ZHENG et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Yuebing ZHENG (Austin, Texas);  Linhan LIN (Austin, Texas);  Jingang LI (Austin, Texas)
ABSTRACT Disclosed herein are methods for patterning two-dimensional atomic layer materials, the methods comprising: illuminating a first location of an optothermal substrate with electromagnetic radiation, wherein the optothermal substrate converts at least a portion of the electromagnetic radiation into thermal energy, and wherein the optothermal substrate is in thermal contact with a two-dimensional atomic layer material; thereby: generating an ablation region at a location of the two-dimensional atomic layer material proximate to the first location of the optothermal substrate, wherein at least a portion of the ablation region has a temperature sufficient to ablate at least a portion of the two-dimensional atomic layer material within the ablation region, thereby patterning the two-dimensional atomic layer material. Also disclosed herein are systems for performing the methods described herein, patterned two-dimensional atomic layer materials made by the methods described herein and methods of use thereof.
FILED Monday, July 22, 2019
APPL NO 17/262015
CURRENT CPC
Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor;
G03F 7/202 (20130101) Original (OR) Class
G03F 7/213 (20130101)
G03F 7/702 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311754 Borkar et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Qualcomm Intelligent Solutions, Inc. (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) Shekhar Yeshwant Borkar (Beaverton, Oregon);  David Stewart Dunning (Portland, Oregon);  Nitin Yeshwant Borkar (Redmond, Washington);  Rishi Khan (Wilmington, Delaware);  Matthew Scott Radecic (San Diego, California)
ABSTRACT Emulating scratchpad functionality using caches in processor-based devices is disclosed. In one aspect, each cache line within a cache of a processor-based device is associated with a corresponding scratchpad indicator indicating whether the corresponding cache line is exempt from the replacement policy used to select a cache line for eviction. Upon receiving data that corresponds to a memory access operation indicated as requiring scratchpad functionality, the cache controller stores the data in a cache line of the cache, and then sets the corresponding scratchpad indicator for the cache line. Subsequently, the cache controller emulates scratchpad functionality by allowing conventional memory read and write operations to be performed on the cache line, but does not apply its replacement policy to that cache line when selecting a cache line as a candidate for eviction. In this manner, the cache line may remain in the cache for use as scratchpad memory by software.
FILED Monday, April 06, 2020
APPL NO 16/840799
CURRENT CPC
Electric Digital Data Processing
G06F 9/455 (20130101) Original (OR) Class
G06F 12/126 (20130101)
G06F 2212/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210312093 BUYUKTOSUNOGLU et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S) INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S) Alper BUYUKTOSUNOGLU (White Plains, New York);  Hyojin SUNG (Ossining, New York)
ABSTRACT Embodiments for mitigating security vulnerabilities in a heterogeneous computing system are provided. Anomalous cache coherence behavior may be dynamically detected between a host and one or more accelerators using a cache controller at a shared last level cache based upon a pair-based coherence messages functioning as a proxy for indicating one or more security attack protocols.
FILED Wednesday, April 01, 2020
APPL NO 16/837793
CURRENT CPC
Electric Digital Data Processing
G06F 12/084 (20130101)
G06F 12/0811 (20130101)
G06F 12/0828 (20130101)
G06F 21/79 (20130101) Original (OR) Class
G06F 21/566 (20130101)
G06F 21/577 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210312298 Kim et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Hyung-il Kim (Minneapolis, Minnesota);  Ibrahim Ahmed (Minneapolis, Minnesota);  Po-wei Chiu (Minneapolis, Minnesota)
ABSTRACT Compute engine circuitry configured to represent a spin network mapping of a graph representing a combinatorial optimization problem includes a plurality of ring oscillator cells, each of which includes a ring oscillator having an oscillator output, at least one coupling block, and a read block. Each coupling block connects the ring oscillator of the cell to the ring oscillator of one of a plurality of neighboring cells to form a coupled ring oscillator. The read block generates a state output for each coupled ring oscillator that indicates whether the coupled ring oscillator is in one of a same-phase state, in which the connected ring oscillators oscillate in phase with each other, and an opposite-phase state, in which the connected ring oscillators oscillate in an opposite phase from each other. A controller is configured to output a total energy of the mapping based on the state outputs.
FILED Friday, March 26, 2021
APPL NO 17/213396
CURRENT CPC
Electric Digital Data Processing
G06F 17/11 (20130101)

Computer Systems Based on Specific Computational Models
G06N 5/003 (20130101) Original (OR) Class
G06N 5/04 (20130101)
G06N 10/00 (20190101)

Pulse Technique
H03K 3/0315 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313188 Glavin et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Secretary of the Air Force (SECAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S) Nicholas R. Glavin (Springboro, Ohio);  Christopher Muratore (Kettering, Ohio);  Melani K. Muratore (Kettering, Ohio)
ABSTRACT The present invention relates to sensors comprising pattern illumination-based annealed coated substrate and one or more functional molecules and process of using same. Such process yields components that can have one or more electronic and/or optical functionalities that are integrated on the same substrate or film and to which one or more functional molecules can be attached to yield a sensor. In addition, such process does not require large-scale clean rooms and is easily configurable. Thus, rapid device prototyping, design change and evolution in the lab and on the production side is realized. The resulting sensors provide a sensing capability that is as good as or better than current sensors and can be tailored to sense specific biomaterials and/or chemicals.
FILED Wednesday, June 02, 2021
APPL NO 17/336799
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/52 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/324 (20130101) Original (OR) Class
H01L 22/14 (20130101)
H01L 29/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313530 Lau et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Christian Lau (Boston, Massachusetts);  Max SHULAKER (Weston, Massachusetts)
ABSTRACT A carbon nanotube field effect transistor (CNFET), that has a channel formed of carbon nanotubes (CNTs), includes a layered deposit of a nonstoichiometric doping oxide (NDO), such as HfOX, where the concentration of the NDO varies through the thickness of the layer(s). An n-type metal-oxide semiconductor (NMOS) CNFET made in this manner can achieve similar ON-current, OFF-current, and/or threshold voltage magnitudes to a corresponding p-type metal-oxide semiconductor (PMOS) CNFET. Such an NMOS and PMOS can be used to achieve a symmetric complementary metal-oxide semiconductor (CMOS) CNFET design.
FILED Wednesday, March 24, 2021
APPL NO 17/211329
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/283 (20130101)
H01L 51/0048 (20130101)
H01L 51/105 (20130101)
H01L 51/107 (20130101) Original (OR) Class
H01L 51/0512 (20130101)
H01L 2251/303 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313756 Baker et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Colin C. Baker (Alexandria, Virginia);  Edward J. Friebele (Cheverly, Maryland);  Woohong Kim (Lorton, Virginia);  L. Brandon Shaw (Woodbridge, Virginia);  Jasbinder S. Sanghera (Ashburn, Virginia)
ABSTRACT Methods for synthesizing fibers having nanoparticles therein are provided, as well as preforms and fibers incorporating nanoparticles. The nanoparticles may include one or more rare earth ions selected based on fluorescence at eye-safer wavelengths, surrounded by a low-phonon energy host. Nanoparticles that are not doped with rare earth ions may also be included as a co-dopant to help increase solubility of nanoparticles doped with rare earth ions in the silica matrix. The nanoparticles may be incorporated into a preform, which is then drawn to form fiber. The fibers may beneficially be incorporated into lasers and amplifiers that operate at eye safer wavelengths. Lasers and amplifiers incorporating the fibers may also beneficially exhibit reduced Stimulated Brillouin Scattering.
FILED Tuesday, June 22, 2021
APPL NO 17/354466
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 20/00 (20130101)

Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials
C03C 13/04 (20130101)
C03C 13/045 (20130101)
C03C 14/006 (20130101)
C03C 2214/16 (20130101)

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/169 (20130101)
H01S 3/176 (20130101)
H01S 3/1603 (20130101)
H01S 3/06716 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210314176 Cambou
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
United States Air Force (USAF)
APPLICANT(S) Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona)
ASSIGNEE(S)
INVENTOR(S) Bertrand F. Cambou (Flagstaff, Arizona)
ABSTRACT Systems and methods for symmetric encryption between a client and a server device include a client device having an array of physical unclonable function devices and a server device storing information sufficient to reconstruct responses of the devices to an applied stimulus such as varying levels of electrical current. The server shares a challenge with the client, which measures characteristics such as electrical resistances for a subset of the devices according to instructions extracted from the challenge. The client measures a corresponding reference device in the array for each device of the subset and assigns a value determined based on a comparison of each device with the corresponding reference device to generate a cryptographic key. The server calculates an expected response of the client to the challenge according to a model of the devices in the array, and uses the calculated response to generate the key independently.
FILED Friday, April 02, 2021
APPL NO 17/221180
CURRENT CPC
Electric Digital Data Processing
G06F 11/1044 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/3278 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210314373 ETHIER et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of the Navy (DON)
Space and Naval Warfare Systems (SPAWAR)
APPLICANT(S) The MITRE Corporation (McLean, Virginia)
ASSIGNEE(S)
INVENTOR(S) Randall Paul Joseph ETHIER (Burke, Virginia);  Gene Lee HARRISON (Leesburg, Virginia)
ABSTRACT Disclosed herein are system, apparatus, method and/or computer program product embodiments for providing survivable calling and conferencing. An embodiment operates by providing, by a first server, a first sub-conference to a plurality of user devices over first lines. The first sub-conference is combined with a second sub-conference to form a collective conference of the plurality of user devices. The first server accesses the conference. A second server is configured to provide the second sub-conference of the collective conference to the plurality of user devices over second lines, the first and second lines being distinct from each other. The collective conference may provide resilient and reliable sharing of information among participants and may leverage dispersed elements or diverse links simultaneously without impediments of echoes, loops, or other impacts.
FILED Friday, December 11, 2020
APPL NO 17/119187
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 65/80 (20130101)
H04L 65/403 (20130101) Original (OR) Class
H04L 65/1073 (20130101)
H04L 65/1096 (20130101)
H04L 65/4076 (20130101)
H04L 67/10 (20130101)
H04L 69/40 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210314677 McPartland
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
U.S. Air Force
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Michael D. McPartland (Westford, Massachusetts)
ABSTRACT Embodiments provide functionality to remotely observe atmospheric conditions. An embodiment, in response to receiving an indication of existence of an airborne aircraft, automatically selects an antenna from a plurality of fixed antennas based on a location and an orientation of each antenna of the plurality of fixed antennas. In turn, a request for data is sent to the aircraft using the selected antenna and, in response to the request, data is received from the aircraft. The data received from the aircraft is automatically processed in a manner determining an atmospheric condition.
FILED Friday, September 25, 2020
APPL NO 17/033339
CURRENT CPC
Meteorology
G01W 1/02 (20130101)
G01W 1/08 (20130101)
G01W 2001/003 (20130101)

Transmission
H04B 7/18506 (20130101)

Selecting
H04Q 9/00 (20130101) Original (OR) Class
H04Q 2209/40 (20130101)

Wireless Communication Networks
H04W 4/44 (20180201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210315099 Rogers et al.
FUNDED BY
Department of Defense (DOD)
Flexible Hybrid Electronics Manufacturing Innovation Institute (FHE-MII)
Department of Transportation (USDOT)
Federal Aviation Administration (FAA)
APPLICANT(S) THE BOEING COMPANY (CHICAGO, Illinois)
ASSIGNEE(S) THE BOEING COMPANY (CHICAGO, Illinois)
INVENTOR(S) John E. Rogers (Owens Cross Roads, Alabama);  John D. Williams (Decatur, Alabama)
ABSTRACT A flexible electronics assembly including a substrate including one or more dielectrics. A cavity is formed within the substrate. A first ground plane is secured to the substrate. One or more stress channels are formed through one or more portions of the substrate and the first ground plane. An electronics component is disposed within the cavity.
FILED Friday, April 03, 2020
APPL NO 16/839565
CURRENT CPC
Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/05 (20130101)
H05K 1/115 (20130101)
H05K 1/189 (20130101)
H05K 1/0271 (20130101)
H05K 1/0281 (20130101) Original (OR) Class
H05K 1/0393 (20130101)
H05K 2201/05 (20130101)
H05K 2201/093 (20130101)
H05K 2201/0183 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 20210308489 FRIEDMAN
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Integrated Sensors, LLC (Ottawa Hills, Ohio)
ASSIGNEE(S)
INVENTOR(S) Peter S. FRIEDMAN (Ottawa Hills, Ohio)
ABSTRACT Embodiments are directed generally to an ionizing-radiation beamline monitoring system that includes a vacuum chamber structure with vacuum compatible flanges through which an incident ionizing-radiation beam enters the monitoring system. Embodiments further include at least one scintillator within the vacuum chamber structure that can be at least partially translated in the ionizing-radiation beam while oriented at an angle greater than 10 degrees to a normal of the incident ionizing-radiation beam, a machine vision camera coupled to a light-tight structure at atmospheric/ambient pressure that is attached to the vacuum chamber structure by a flange attached to a vacuum-tight viewport window with the camera and lens optical axis oriented at an angle of less than 80 degrees with respect to a normal of the scintillator, and at least one ultraviolet (“UV”) illumination source facing the scintillator in the ionizing-radiation beam for monitoring a scintillator stability comprising scintillator radiation damage.
FILED Thursday, May 27, 2021
APPL NO 17/332047
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/00 (20130101)
A61N 5/1045 (20130101)
A61N 5/1048 (20130101)
A61N 5/1049 (20130101)
A61N 5/1064 (20130101)
A61N 5/1067 (20130101) Original (OR) Class
A61N 2005/1059 (20130101)

Measurement of Nuclear or X-radiation
G01T 1/40 (20130101)
G01T 1/1612 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308616 Panaccione et al.
FUNDED BY
Department of Energy (DOE)
National Energy Technology Laboratory (NETL)
APPLICANT(S) ION Engineering, LLC (Boulder, Colorado)
ASSIGNEE(S)
INVENTOR(S) Charles Panaccione (Boulder, Colorado);  Nathan R. Brown (Oslo, Norway);  Erik Everhardus Bernardus Meuleman (Boulder, Colorado)
ABSTRACT A chemical processing system for removing carbon dioxide from a gas mixture using a multicomponent amine-based scrubbing solution includes a spectroscopic evaluation system with a liquid contact probe for spectroscopic investigation, an energy source connected with the liquid contact probe to provide the spectroscopic stimulation energy to the probe, a spectrometer connected with the liquid contact probe to detect the spectroscopic response energy to the probe and to output spectral data corresponding to the spectroscopic response energy, and a machine learning spectral data analyzer connected to the spectrometer for evaluation of the spectral data to determine a concentration value for each of water, amine component and captured carbon dioxide in the scrubbing solution, the machine learning spectral data analyzer being trained for each such component over a corresponding trained concentration range, and optionally over a trained temperature range to provide a temperature-compensated concentration value.
FILED Friday, May 07, 2021
APPL NO 17/314848
CURRENT CPC
Separation
B01D 53/18 (20130101)
B01D 53/1412 (20130101) Original (OR) Class
B01D 53/1425 (20130101)
B01D 53/1475 (20130101)
B01D 2252/204 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/3504 (20130101)
G01N 2021/3595 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308651 Baumann et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livemore, California)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (, None)
INVENTOR(S) Theodore F. Baumann (Discovery Bay, California);  Joe H. Satcher, JR. (Patterson, California);  Joseph C. Farmer (Tracy, California)
ABSTRACT A product includes a highly adsorptive structure comprising: a substrate, wherein the substrate comprises a plurality of microchannels; and a carbon aerogel adhered to the substrate. The carbon aerogel is characterized by having physical characteristics of in situ formation on the substrate. Moreover, An adsorptive cooling system includes: a first highly adsorptive structure positioned to receive thermal energy from a thermal energy source, the first highly adsorptive structure comprising: a first substrate; and a first carbon aerogel adhered to the first substrate; a second highly adsorptive structure positioned to receive thermal energy from the thermal energy source, the second highly adsorptive structure comprising: a second substrate; and a second carbon aerogel adhered to the second substrate. The first substrate and/or the second substrate independently comprise a plurality of microchannels.
FILED Thursday, June 17, 2021
APPL NO 17/351026
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/06 (20130101)
B01J 20/20 (20130101) Original (OR) Class
B01J 20/103 (20130101)
B01J 20/2804 (20130101)
B01J 20/3085 (20130101)
B01J 20/28042 (20130101)
B01J 20/28047 (20130101)
B01J 20/28052 (20130101)
B01J 20/28066 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 5/047 (20130101)

Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems
F25B 17/083 (20130101)
F25B 27/007 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308658 LIU et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Di-Jia LIU (Elmhurst, Illinois);  Lina CHONG (Naperville, Illinois)
ABSTRACT A nanofibrous catalyst for in the electrolyzer and methods of making the catalyst. The catalysts are composed of highly porous transition metal carbonitrides, metal oxides or perovskites derived from the metal-organic frameworks and integrated into a 3D porous nano-network electrode architecture. The catalysts are low-cost, highly active toward OER, with excellent conductivity yet resistant to the oxidation under high potential operable under both acidic and alkaline environments.
FILED Monday, June 14, 2021
APPL NO 17/346518
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 21/185 (20130101)
B01J 23/10 (20130101)
B01J 23/20 (20130101)
B01J 23/28 (20130101)
B01J 23/34 (20130101)
B01J 23/75 (20130101)
B01J 23/83 (20130101)
B01J 23/745 (20130101)
B01J 23/8871 (20130101)
B01J 27/24 (20130101)
B01J 31/1691 (20130101) Original (OR) Class
B01J 35/002 (20130101)
B01J 35/06 (20130101)
B01J 35/0033 (20130101)
B01J 35/1014 (20130101)
B01J 35/1019 (20130101)
B01J 35/1023 (20130101)
B01J 35/1057 (20130101)
B01J 35/1061 (20130101)
B01J 37/04 (20130101)
B01J 37/084 (20130101)
B01J 37/348 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)

Compositions of Macromolecular Compounds
C08L 23/0853 (20130101)
C08L 33/12 (20130101)
C08L 33/20 (20130101)
C08L 39/06 (20130101)
C08L 75/04 (20130101)
C08L 77/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308663 LEE et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Laboratory (LANL)
Los Alamos National Security, LLC (LANS)
National Science Foundation (NSF)
APPLICANT(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
ASSIGNEE(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
INVENTOR(S) Sangwoo LEE (Cohoes, New York);  Chulsung BAE (Cohoes, New York);  Musashi J. BRIEM (Troy, New York);  Sungmin PARK (Troy, New York)
ABSTRACT The anion exchange membranes exhibit enhanced chemical stability and ion conductivity when compared with traditional styrene-based alkaline anion exchange membranes. A copolymer backbone is polymerized from a reaction medium that includes a diphenylalkylene and an alkadiene. The copolymer includes a plurality of pendant phenyl groups. The diphenyl groups on the polymer backbone are functionalized with one or more haloalkylated precursor substrates. The terminal halide from the precursor substrate can then be substituted with a desired ionic group. The diphenylethylene-based alkaline anion exchange membranes lack the α-hydrogens sharing tertiary carbons with phenyl groups from polystyrene or styrene-based precursor polymers, resulting in higher chemical stability. The ionic groups are also apart from each other by about 3 to 6 carbons in the polymer backbone, enhancing ion conductivity. These membrane are advantageous for use in fuel cells, electrolyzers employing hydrogen, ion separations, etc.
FILED Tuesday, October 22, 2019
APPL NO 17/287639
CURRENT CPC
Separation
B01D 61/44 (20130101)
B01D 71/06 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 41/07 (20170101) Original (OR) Class
B01J 41/14 (20130101)
B01J 47/12 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/469 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 212/32 (20130101)
C08F 2810/00 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/2287 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309525 BADDOUR et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Frederick G. BADDOUR (Denver, Colorado);  Anurag KUMAR (Golden, Colorado);  Kurt Michael VAN ALLSBURG (Denver, Colorado);  Daniel RUDDY (Arvada, Colorado);  Susan E. HABAS (Arvada, Colorado);  Andrew ROYAPPA (Cantonment, Florida);  Brittney E. PETEL (Lakewood, Colorado);  Claire Townsend NIMLOS (Lakewood, Colorado)
ABSTRACT The present disclosure relates to a method for producing a metal carbide, where the method includes thermally treating a molecular precursor in an oxygen-free environment, such that the treating produces the metal carbide and the molecular precursor includes where M is the metal of the metal carbide, N* includes nitrogen or a nitrogen-containing functional group, and x is between zero and six, inclusively.
FILED Tuesday, March 23, 2021
APPL NO 17/210076
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 27/22 (20130101)
B01J 37/08 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 32/90 (20170801) Original (OR) Class

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 11/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309549 Demirtas
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Meltem Urgun Demirtas (Naperville, Illinois)
ABSTRACT Provided herein are methods of organic waste stream conversion including fermenting an organic waste stream with an inoculum using arrested methanogenesis to generate an organic product. The inoculum includes an anaerobic consortium isolated from cheese, yogurt, saline soil, kefir, and/or probiotics and the anaerobic consortium is pretreated to transform the anaerobic consortium into an acidogenic consortium
FILED Friday, March 05, 2021
APPL NO 17/249608
CURRENT CPC
Separation
B01D 15/363 (20130101)
B01D 61/022 (20130101)
B01D 61/025 (20130101)
B01D 61/027 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 3/28 (20130101)
C02F 3/341 (20130101) Original (OR) Class
C02F 11/04 (20130101)
C02F 2103/32 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/08 (20130101)
C12P 7/40 (20130101)
C12P 7/52 (20130101)
C12P 7/54 (20130101)
C12P 7/56 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309802 Helms et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Berkeley National Laboratory (LBNL)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Brett A. Helms (Oakland, California);  Swagat Sahu (Oakland, California);  Miranda J. Baran (Onartio, Canada);  Miles N. Braten (San Francisco, California);  Mark E. Carrington (Port of Spain, Trinidad/Tobago);  Stephen M. Meckler (Redwood City, California)
ABSTRACT The present disclosure is directed to raicroporous ladder polymers containing amine-functionalized monomer segments, amidoxime-functionalized monomer segments, or a combination thereof. Monomer compounds for preparation of the polymers are also described, as well as membranes and electrochemical cells containing the polymers.
FILED Friday, August 16, 2019
APPL NO 17/269228
CURRENT CPC
Separation
B01D 67/0009 (20130101)
B01D 69/02 (20130101)
B01D 71/52 (20130101)
B01D 2325/02 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 39/07 (20170101)
B01J 39/19 (20170101)

Acyclic or Carbocyclic Compounds
C07C 215/64 (20130101)

Heterocyclic Compounds
C07D 211/46 (20130101)
C07D 295/135 (20130101)
C07D 295/205 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 65/48 (20130101) Original (OR) Class
C08G 65/4006 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/24 (20130101)
H01M 50/403 (20210101)
H01M 50/414 (20210101)
H01M 50/491 (20210101)
H01M 2300/0014 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309818 BAE et al.
FUNDED BY
Department of Energy (DOE)
National Science Foundation (NSF)
APPLICANT(S) Chulsung BAE (Cohoes, New York);  Chang Y. RYU (Loudonville, New York);  Ding TIAN (Troy, New York)
ASSIGNEE(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
INVENTOR(S) Chulsung BAE (Cohoes, New York);  Chang Y. RYU (Loudonville, New York);  Ding TIAN (Troy, New York)
ABSTRACT An anion exchange membrane is provided by converting carbon-carbon double bonds in the backbone of polystyrene-block-polybutadiene-block-polystyrene (SBS) into epoxide groups. Unmodified SBS is first partially hydrogenated to remove about 65% to about 90% of carbon-carbon double bonds. The remaining double bonds are then converted to epoxide groups to form an epoxidized SBS. UV-initiated ring opening reactions between the epoxidized SBS and haloalkyloxiranes are then employed to simultaneously functionalize and crosslink the epoxidized SBS. The halide groups in the crosslinked polymer network can be replaced via nucleophilic substitution to offer anion conductivity, e.g., via reaction with trimethylamine. Further ion exchange reactions can then be performed to make the membrane hydroxide conductive. The crosslinked membranes described herein exhibit a mechanical strength improvement of 200% compared to unmodified SBS, while maintaining high hydroxide conductivity. This synthetic platform is advantageous to provide mechanically robust anion exchange membranes for fuel cell applications.
FILED Tuesday, April 06, 2021
APPL NO 17/223544
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 41/14 (20130101)
B01J 47/12 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 293/00 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/2287 (20130101) Original (OR) Class
C08J 2309/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309822 BULGER et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) PALO ALTO RESEARCH CENTER INCORPORATED (Palo Alto, California)
ASSIGNEE(S)
INVENTOR(S) ELI BULGER (NOTTAWA, Canada);  MAHATI CHINTAPALLI (MOUNTAIN VIEW, California);  GABRIEL IFTIME (DUBLIN, California);  QUENTIN VAN OVERMEERE (MOUNTAIN VIEW, California);  JESSICA LOUIS BAKER RIVEST (PALO ALTO, California);  RAVI NEELAKANTAN (REDWOOD CITY, California);  STEPHEN MECKLER (REDWOOD CITY, California)
ABSTRACT A method of producing a polymer aerogel includes dissolving precursors into a solvent, wherein the precursors include monomers, crosslinkers, a controlling agent and an initiator to form a precursor solution, wherein at least one of the monomers or at least one of the crosslinkers has a refractive index of 1.5 or lower, polymerizing the precursor solution to form a gel polymer, and removing the solvent from the gel polymer to produce the polymer aerogel. A method of producing a polymer aerogel include dissolving precursors into a solvent, wherein the precursors include monomers, crosslinkers, a controlling agent and an initiator to form a precursor solution, polymerizing the precursor solution to form a gel polymer, removing the solvent from the gel polymer to produce the polymer aerogel, and reducing a refractive index of one of either the gel polymer or the polymer aerogel.
FILED Friday, April 30, 2021
APPL NO 17/245418
CURRENT CPC
Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/242 (20130101)
C08J 9/0004 (20130101) Original (OR) Class
C08J 9/286 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 5/0025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309845 NEYERLIN et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Kenneth Charles NEYERLIN (Arvada, Colorado);  Yawei LI (Taiyuan Shanxi, China PRC);  Timothy Blair VAN CLEVE (Denver, Colorado)
ABSTRACT The present disclosure relates to a composition that includes a fluoropolymer, a polymerized ionic liquid block copolymer (PILBC), and a catalyst, where the fluoropolymer is configured to affect ionic mobility, and the PILBC is configured to affect a property of the catalyst. In some embodiments of the present disclosure, the property may include at least one of oxygen transport and/or an active site functionality of the catalyst.
FILED Wednesday, March 31, 2021
APPL NO 17/219201
CURRENT CPC
Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/04 (20130101)
C08K 2201/001 (20130101)

Compositions of Macromolecular Compounds
C08L 27/22 (20130101) Original (OR) Class
C08L 53/005 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 8/1004 (20130101)
H01M 8/1027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309908 Taha et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
National Science Foundation (NSF)
APPLICANT(S) UNM Rainforest Innovations (Albuquerque, New Mexico);  National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico);  Transpo Industries, Inc. (New Rochelle, New York)
ASSIGNEE(S) UNM Rainforest Innovations (Albuquerque, New Mexico);  National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico);  Transpo Industries, Inc. (New Rochelle, New York)
INVENTOR(S) Mahmoud Reda Taha (Albuquerque, New Mexico);  Michael S. Stenko (Albuquerque, New Mexico);  John Stormont (Albuquerque, New Mexico);  Edward N. Matteo (Albuquerque, New Mexico);  Moneeb Genedy (Albuquerque, New Mexico);  Thomas Dewers (Albuquerque, New Mexico)
ABSTRACT A method and sealant to seal microcracks as small as 50 μm by causing methyl methacrylate combined with one or more nanoparticles to flow into the microcrack to be sealed.
FILED Tuesday, June 15, 2021
APPL NO 17/348685
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 8/428 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 33/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309975 Bowie et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) James U. Bowie (Los Angeles, California);  Meaghan Valliere (Leominster, Massachusetts);  Tyler P. Korman (Sierra Madre, California);  Nicholas Woodall (Knoxville, Tennessee)
ABSTRACT Provided is an enzyme useful for prenylation and recombinant pathways for the production of cannabinoids, cannabinoid precursors and other prenylated chemicals in a cell free system as well and recombinant microorganisms that catalyze the reactions.
FILED Thursday, August 01, 2019
APPL NO 17/264758
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1085 (20130101) Original (OR) Class

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/22 (20130101)
C12P 7/42 (20130101)
C12P 9/00 (20130101)
C12P 17/06 (20130101)

Enzymes
C12Y 205/01039 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309980 Gill et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Ryan T. Gill (Boulder, Colorado);  Rongming Liu (Boulder, Colorado)
ABSTRACT Embodiments of the present disclosure relate to engineered chimeric nucleic acid guided nucleases for improved targeted gene editing. In certain embodiments, the engineered chimeric nucleic acid guided nucleases can be used for genome editing. In accordance with these embodiments, a targeted genome can be edited by one or more of the engineered chimeric nucleic acid guided nucleases comprising one or more nucleic acid or amino acid constructs represented by one or more of SEQ ID NO:1 to SEQ ID NO:9 or a polypeptide encoded thereof. In certain embodiments, the engineered chimeric nucleic acid guided nucleases can be used to remove, edit, and/or insert genes into a targeted genome. In other embodiments, use of these chimeras can be for producing a targeted result (e.g. removing, editing or replacing a defective gene) in a subject to reduce the onset of or prevent a condition.
FILED Thursday, March 25, 2021
APPL NO 17/212484
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101) Original (OR) Class
C12N 15/11 (20130101)
C12N 15/902 (20130101)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310132 Hoyt et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Nathaniel C. Hoyt (Clarendon Hills, Illinois);  Jicheng Guo (Woodridge, Illinois);  Mark A. Williamson (Naperville, Illinois)
ABSTRACT The invention provides an in situ method for protecting material exposed to molten salt, the method having the steps of supplying metal in a first nonreactive state to the molten salt to create a mixture; measuring a redox state of the mixture; and transforming the metal to a second reactive state when the redox state indicates corrosion of the material is about to occur. Also provided is a system for preventing corrosion of structural alloys in molten salt environments, the system having a vessel defining a void containing the molten salt; a voltammetry sensor inserted into the molten salt; a first cathode inserted into the molten salt; and a first anode inserted into the molten salt, whereby the cathode and anode are in electrical communication with an electrical power source.
FILED Wednesday, April 01, 2020
APPL NO 16/837568
CURRENT CPC
Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25
C23F 13/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310461 KING et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Jennifer Rose KING (Arvada, Colorado);  Paul Aaron FLEMING (Boulder, Colorado);  Emiliano DALL'ANESE (Arvada, Colorado);  Christopher Joseph BAY (Arvada, Colorado);  Peter Andrew GRAF (Boulder, Colorado)
ABSTRACT Disclosed herein are methods, systems, and devices for utilizing distributed reinforcement learning and consensus control to most effectively generate and utilize energy. In some embodiments, individual turbines within a wind farm may communicate to reach a consensus as to the desired yaw angle based on the wind conditions.
FILED Wednesday, July 31, 2019
APPL NO 17/264967
CURRENT CPC
Wind Motors
F03D 7/046 (20130101)
F03D 7/048 (20130101)
F03D 7/0204 (20130101) Original (OR) Class
F03D 17/00 (20160501)

Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G
F05B 2270/326 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310895 McDaniel et al.
FUNDED BY
Department of Energy (DOE)
National Energy Technology Laboratory (NETL)
APPLICANT(S) Dwayne E. McDaniel (Miramar, Florida);  Mackenson Telusma (Miami, Florida);  Leonel E. Lagos (Miami, Florida)
ASSIGNEE(S) The Florida International University Board of Trustees (Miami, Florida)
INVENTOR(S) Dwayne E. McDaniel (Miramar, Florida);  Mackenson Telusma (Miami, Florida);  Leonel E. Lagos (Miami, Florida)
ABSTRACT Robotic devices that can be utilized on pipes of any material and of a variety of pipe diameters are provided. The robotic device utilizes a ducted fan to create the normal forces needed to adhere to any part of a pipe. The chassis of the device can be segmented to allow for application on various diameter pipes.
FILED Friday, April 02, 2021
APPL NO 17/221192
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 5/007 (20130101)
B25J 9/0009 (20130101)
B25J 13/006 (20130101)

Vehicle Wheels; Castors; Axles for Wheels or Castors; Increasing Wheel Adhesion
B60B 19/003 (20130101)

Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for
G01M 5/0025 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310923 Galbreth et al.
FUNDED BY
Department of Energy (DOE)
Battelle Energy Alliance, LLC (BEA)
APPLICANT(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)
INVENTOR(S) Gregory G. Galbreth (Idaho Falls, Idaho);  Ammon N. Williams (Rigby, Idaho)
ABSTRACT A triple bubbler system includes a first fluid probe, a second fluid probe, a third fluid probe, an gas source operably coupled to the first fluid probe, the second fluid probe, and the third fluid probe and configured to meter gas through the first fluid probe, the second fluid probe, and the third fluid probe to form bubbles at tips of each of the first fluid probe, the second fluid probe, and the third fluid probe, and a cover member disposed over the tips of the first, second, and third fluid probes and configured to at least partially prevent bubbles formed and escaping the tips of the first, second, and third fluid probes from interfering with other bubbles formed at each other tips. The bubbler system includes a thermocouple having a plurality of junctions disposed along an axis parallel to longitudinal axes of the first, second, and third fluid probes.
FILED Tuesday, March 16, 2021
APPL NO 17/249849
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 9/28 (20130101)
G01N 13/02 (20130101) Original (OR) Class
G01N 25/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310944 Zhang et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) The University of Chicago (Chicago, Illinois);  UChicago Argonne, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Xufeng Zhang (Westmont, Illinois);  Supratik Guha (Chicago, Illinois);  Tijana Rajh (Naperville, Illinois)
ABSTRACT The present disclosure relates to systems and methods suitable to measure trace amounts of specific ions in fluid samples. An example system includes a resonator having an input coupler and an output coupler. The example system also includes an ion-selective membrane (ISM) optically coupled to at least a portion of the resonator. The system additionally includes a light source configured to illuminate the resonator by way of the input coupler. Furthermore, the system includes a detector configured to receive output light by way of the output coupler and provide information indicative a concentration of a specific ion proximate to tire ISM.
FILED Tuesday, July 23, 2019
APPL NO 17/262195
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/41 (20130101) Original (OR) Class
G01N 2201/06113 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311041 Sava Gallis et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
Sandia National Laboratories (SNL)
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Dorina F. Sava Gallis (Albuquerque, New Mexico);  Kimberly Butler (Albuquerque, New Mexico)
ABSTRACT Metal-organic frameworks (MOFs) comprising amines on the organic linker can be used for cell targeting. In particular, primary amine groups represent one of the most versatile chemical moieties for conjugation to biologically relevant molecules, including antibodies and enzymes. Different chemical conjugation schemes can be used to conjugate biological molecules to the amino functionality on the organic linker. For example, carbodiimide chemistry can be used to link a primary amine to available carboxyl groups on the protein. For example, sulfhydryl crosslinking chemistry can be used via Traut's reagent scheme. As a demonstration of the invention, the ability of EpCAM antibody-targeted MOFs to bind to a human epithelial cell line (A549), a common target for imaging studies, was confirmed with confocal microscopy.
FILED Wednesday, April 28, 2021
APPL NO 17/243417
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/544 (20130101)
G01N 33/54353 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210312744 Bruer
FUNDED BY
Department of Energy (DOE)
Savannah River Nuclear Solutions, LLC (SRNS)
APPLICANT(S) Ocean Bay Information and Systems Management, LLC (Hanahan, South Carolina)
ASSIGNEE(S)
INVENTOR(S) Karen Bruer (Hanahan, South Carolina)
ABSTRACT The present disclosure relates to portable devices for detecting substandard or counterfeit materials on-site at ports of entry or other locations where the materials are situated, preferably before acceptance or entry of such materials into the supply chain. In particular, the devices and methods relate to use of a handheld probe capable of applying a temperature change to the surface of a suspect material at a contact area, sensing the material's temperature response at one or more surface locations distinct from the contact area, and comparing the temperature response data to a reference standard, which corresponds to temperature response of a standard or noncounterfeit sample.
FILED Wednesday, March 31, 2021
APPL NO 17/218521
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 25/18 (20130101)

Handling of Coins or Valuable Papers, e.g Testing, Sorting by Denominations, Counting, Dispensing, Changing or Depositing
G07D 7/15 (20170501) Original (OR) Class
G07D 7/17 (20170501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210312837 Ziock et al.
FUNDED BY
Department of Energy (DOE)
UT-Battelle, LLC (UT-BATTELLE)
Oak Ridge National Laboratory (ORNL)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Klaus-Peter Ziock (Oak Ridge, Tennessee);  William R. Ray (Oak Ridge, Tennessee);  James R. Younkin (Oak Ridge, Tennessee);  Brandon R. Longmire (Oak Ridge, Tennessee)
ABSTRACT A fiber Bragg grating (FBG) security component for single-party and multi-party monitoring is provided. The security component includes an optical fiber having a plurality of Bragg gratings. The Bragg gratings provide a spectral response that is randomized based on the manufacture of the security component. For single-party use, the spectral response provides a reproducible spectral signature when interrogated with an optical signal. For multi-party use, each party applies a known optical interrogation signal to the security component and applies an external stress known only to the respective monitoring party. The resulting shift in the spectral signature is unique to each monitoring party, making it extremely difficult to successfully counterfeit the security component's response for all such parties.
FILED Tuesday, April 06, 2021
APPL NO 17/223616
CURRENT CPC
Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for
G01D 5/35316 (20130101)

Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for
G01K 11/3206 (20130101)

Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure
G01L 1/246 (20130101)

Displaying; Advertising; Signs; Labels or Name-plates; Seals
G09F 3/0376 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210312952 JAYASENA et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
National Nuclear Security Administration (NNSA)
APPLICANT(S) ADVANCED MICRO DEVICES, INC. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S) Nuwan S. JAYASENA (Santa Clara, California);  Yasuko ECKERT (Bellevue, Washington)
ABSTRACT A processing system includes a plurality of processor cores formed in a first layer of an integrated circuit device and a plurality of partitions of memory formed in one or more second layers of the integrated circuit device. The one or more second layers are deployed in a stacked configuration with the first layer. Each of the partitions is associated with a subset of the processor cores that have overlapping footprints with the partitions. The processing system also includes first memory paths between the processor cores and their corresponding subsets of partitions. The processing system further includes second memory paths between the processor cores and the partitions.
FILED Wednesday, April 07, 2021
APPL NO 17/224603
CURRENT CPC
Electric Digital Data Processing
G06F 12/0811 (20130101)
G06F 12/0888 (20130101)
G06F 2212/251 (20130101)
G06F 2212/254 (20130101)
G06F 2212/502 (20130101)
G06F 2212/1016 (20130101)

Static Stores
G11C 5/025 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313081 Nygaard et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) BWXT Technical Services Group, Inc. (Charlotte, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Erik T. Nygaard (Lynchburg, Virginia);  Peter L. Angelo (Oak Ridge, Tennessee);  Scott B. Aase (Aiken, South Carolina)
ABSTRACT The present invention relates generally to the field of compensation methods for nuclear reactors and, in particular to a method for fail-safe reactivity compensation in solution-type nuclear reactors. In one embodiment, the fail-safe reactivity compensation method of the present invention augments other control methods for a nuclear reactor. In still another embodiment, the fail-safe reactivity compensation method of the present invention permits one to control a nuclear reaction in a nuclear reactor through a method that does not rely on moving components into or out of a reactor core, nor does the method of the present invention rely on the constant repositioning of control rods within a nuclear reactor in order to maintain a critical state.
FILED Wednesday, June 16, 2021
APPL NO 17/349595
CURRENT CPC
Nuclear Reactors
G21C 1/24 (20130101)
G21C 3/24 (20130101)
G21C 7/30 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313103 Kashikhin
FUNDED BY
Department of Energy (DOE)
Fermi National Accelerator Laboratory (FNAL)
Fermi Research Alliance, LLC (FRA)
APPLICANT(S) Fermi Research Alliance, LLC (Batavia, Illinois)
ASSIGNEE(S) Fermi Research Alliance, LLC (Batavia, Illinois)
INVENTOR(S) Vadim V. Kashikhin (North Aurora, Illinois)
ABSTRACT A Conductor on Molded Barrel (COMB) magnet assembly optimized for High Temperature Superconducting (HTS) materials. The magnet assembly comprises a magnetic coil(s) carried by a conductor support structure and configured in cosine-theta geometry. Created using additive manufacturing, the conductor support structure features a continuous cable channel that fittedly carries and positions elongated straight portion(s) of the magnetic coil(s) parallel to a magnetic axis. The conductor support structure may be cylindrically shaped and longitudinally bored, with the continuous cable channel comprising an outer channel portion (distal on the cylinder) and an inner channel portion (proximal on the cylinder). A transition hole that joins the outer channel portion and the inner channel portion allows a single magnetic coil to be wound along both the outer and inner surfaces of the conductor support structure. The conductor support structure may be fabricated as longitudinally-symmetrical halves, and secured for operation using azimuthal and/or midplane shims.
FILED Monday, April 06, 2020
APPL NO 16/841475
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 3/1055 (20130101)

Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam
B23K 26/342 (20151001)
B23K 26/354 (20151001)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 70/00 (20141201)
B33Y 80/00 (20141201)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 1/147 (20130101)
H01F 6/06 (20130101) Original (OR) Class
H01F 41/048 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313517 THOMPSON et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) University of Southern California (Los Angeles, California)
ASSIGNEE(S)
INVENTOR(S) Mark E. THOMPSON (Anaheim, California);  Jonathan R. SOMMER (Los Angeles, California);  Andrew Bartynski (Los Angeles, California)
ABSTRACT Acenes, such as aza-acenes are attractive materials for organic semiconductors, specifically for n-type materials. There are disclosed new derivatives of acenes that are fabricated using novel synthesis. For example, the disclosed fabrication strategies have allowed for the first time new aza-tetracene and aza-pentacene derivatives. The HOMO and LUMO energy levels of these materials are tunable through appropriate substitution and as predicted, deepened. There are also disclosed organic photosensitive devices comprising at least one aza-acene such as aza-tetracene and aza-pentacene.
FILED Tuesday, October 20, 2020
APPL NO 17/074890
CURRENT CPC
Heterocyclic Compounds
C07D 471/04 (20130101)
C07D 471/14 (20130101)
C07D 471/22 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/06 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/0064 (20130101) Original (OR) Class
H01L 51/0072 (20130101)
H01L 51/4246 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313589 Evans et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) ESS TECH, INC. (Wilsonville, Oregon)
ASSIGNEE(S)
INVENTOR(S) Craig E. Evans (West Linn, Oregon);  Yang Song (West Linn, Oregon);  Jeffrey Chen (Portland, Oregon)
ABSTRACT An electrode for use in an all-iron redox flow battery is provided. In one example, the electrode may include a plastic mesh; and a coating on the plastic mesh. The coating may be a hydrophilic coating or a conductive coating and the electrode may have an electrode reaction potential is less than 0.8V. Further, a method of manufacturing a coated plastic mesh electrode for use in an all-iron redox flow battery is provided. In one example method, the steps include fabricating a plastic mesh, treating the plastic mesh by applying a solvent treatment or a plasma treatment or a mechanical abrasion treatment; coating the plastic mesh with a material selected from: carbon inks, metal oxides, and hydrophilic polymers.
FILED Tuesday, April 20, 2021
APPL NO 17/235810
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/8803 (20130101) Original (OR) Class
H01M 4/8817 (20130101)
H01M 4/8828 (20130101)
H01M 8/18 (20130101)
H01M 8/20 (20130101)
H01M 8/182 (20130101)
H01M 8/184 (20130101)
H01M 8/186 (20130101)
H01M 8/188 (20130101)
H01M 8/0239 (20130101)
H01M 8/0245 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 60/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210314020 Moradi et al.
FUNDED BY
Department of Energy (DOE)
Battelle Energy Alliance, LLC (BEA)
APPLICANT(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)
INVENTOR(S) Hussein Moradi (Idaho Falls, Idaho);  Behrouz Farhang (Salt Lake City, Utah);  Arslan J. Majid (Salt Lake City, Utah)
ABSTRACT Various embodiments relate to spread spectrum modulation. A device may include a processor and at least one transmitter. The device may be configured to add a cyclic prefix (CP) to each block of a number of blocks of a direct sequence spread spectrum (DSSS) signal to generate a cyclic prefix-direct sequence spread spectrum (CP-DSSS) signal. Further, the device may be configured to transmit, via a channel, the CP-DSSS signal. Associated methods and communications systems are also disclosed.
FILED Friday, March 05, 2021
APPL NO 17/249593
CURRENT CPC
Transmission
H04B 1/711 (20130101) Original (OR) Class
H04B 1/7073 (20130101)
H04B 2201/709709 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 20210308219 Jaynes et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) Genvor Inc. (Dallas, Texas);  The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Jesse M. Jaynes (Auburn, Alabama);  Kanniah Rajasekaran (Metairie, Louisiana);  Jeffrey W. Cary (Covington, Louisiana);  Ronald Sayler (Farmington, Arkansas);  Rajtilak Majumdar (Metairie, Louisiana)
ABSTRACT Aspergillus flavus is an opportunistic, saprophytic fungus that infects maize and other fatty acid-rich food and feed crops and produces toxic and carcinogenic secondary metabolites known as aflatoxins. In vitro studies showed a five-fold increase in antifungal activity of AGM182 (vs. tachyplesin1) against A. flavus. Transgenic maize plants expressing AGM182 under maize Ubiquitin-1 promoter were produced through Agrobacterium-mediated transformation. PCR products confirmed integration of the AGM182 gene, while RT-PCR of maize RNA confirmed the presence of AGM182 transcripts. Maize kernel screening assay using a highly aflatoxigenic A. flavus strain (AF70) showed up to 72% reduction in fungal growth in the transgenic AGM182 seeds compared to isogenic negative control seeds.
FILED Monday, June 21, 2021
APPL NO 17/352445
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/1767 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/8205 (20130101)
C12N 15/8216 (20130101)
C12N 15/8282 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210308505 Forsyth
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America as Represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) William Forsyth (Boise, Idaho)
ABSTRACT One or more thermal images containing pixel-by-pixel radiation intensity data in two or more wavelength bands can be processed to accurately determine the location of fire within the image(s), regardless of the radiation-scattering effects of smoke. First, all pixels having radiation intensities above a fire threshold in the longer-wavelength band are classified as being aflame. Second, a threshold curve defining a fire threshold in the shorter-wavelength band is applied to the pixels, and those having radiation intensities above the fire threshold in the shorter-wavelength band are classified as being aflame. Third, at least the second group of pixels above is tested to see if each pixel classified as being aflame is part of a group of adjoining pixels which were all classified as being aflame, and if so, each such pixel is reclassified as not being aflame unless it also falls within the first group of pixels above.
FILED Wednesday, May 17, 2017
APPL NO 15/597666
CURRENT CPC
Fire-fighting
A62C 3/0271 (20130101) Original (OR) Class

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6267 (20130101)

Image Data Processing or Generation, in General
G06T 7/70 (20170101)
G06T 2207/10032 (20130101)
G06T 2207/10048 (20130101)
G06T 2207/30181 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310019 STASKAWICZ et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The Regents of the University of California (Oakland, Japan)
ASSIGNEE(S)
INVENTOR(S) Brian J. STASKAWICZ (Berkeley, California);  Alexander Christiaan SCHULTINK (Williamston, Michigan)
ABSTRACT Provided herein is a plant comprising an exogenous polynucleotide encoding a JIM2 polypeptide. In some embodiments, the plants have enhanced resistance to at least one species of Xanthomonas.
FILED Friday, May 24, 2019
APPL NO 16/973743
CURRENT CPC
Peptides
C07K 14/415 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/8281 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210315143 Kenworthy
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Florida Foundation Seed Producers, Inc. (Marianna, Florida)
ASSIGNEE(S)
INVENTOR(S) Kevin E. Kenworthy (Gainesville, Florida)
ABSTRACT ‘FAES1307’ is a new and distinct zoysiagrass (Zoysia japonica Steud.) variety distinguished at least by its medium leaf texture, high turfgrass quality, good drought tolerance, improved winter turfgrass color retention, and low incidence of large patch disease caused by Rhizoctonia solani anastomosis group 2-2 LP. Compared to its parents and commercial checks, ‘FAES1307’ has a shorter canopy height and is a more prolific producer of stolons. It tends to have shorter leave lengths and moderate leaf widths. Its flag leaf height is similar to its female parent, ‘FAES 5309-12’ while its flag leaf width is similar to its male parent, ‘BA 123’. The seed head heights of ‘FAES 1307’ are shorter and consistent with the height of its female parent, ‘TAES 5309-12’. ‘FAES1307’ and its parents have narrower raceme widths; and shorter raceme lengths compared to to ‘Meyer’ and ‘SS-500’.
FILED Monday, January 25, 2021
APPL NO 17/157899
CURRENT CPC
Plants
PLT/390
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 20210307813 Farritor et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Telemedicine and Advanced Technology Research Center (TATRC)
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Board of Regents of the University of Nebraska (Lincoln, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Shane Farritor (Lincoln, Nebraska);  Thomas Frederick (Gretna, Nebraska);  Joe Bartels (Pittsburgh, Pennsylvania)
ABSTRACT The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector.
FILED Monday, June 21, 2021
APPL NO 17/352817
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 18/1445 (20130101) Original (OR) Class
A61B 2034/301 (20160201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313185 Greer
FUNDED BY
National Aeronautics and Space Administration (NASA)
Jet Propulsion Laboratory (JPL)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S) California Institute of Technology (Pasadena, California)
INVENTOR(S) Harold Frank Greer (Pasadena, California)
ABSTRACT A method for etching a surface including obtaining a substrate comprising a material; reacting a surface of a substrate with a reactant, comprising a gas or a plasma, to form a reactive layer on the substrate, the reactive layer comprising a chemical compound including the reactant and the material; and wet etching or dissolving the reactive layer with a liquid wet etchant of solvent that selectively etches or dissolves the reactive layer but not the substrate.
FILED Tuesday, April 06, 2021
APPL NO 17/224037
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/30604 (20130101) Original (OR) Class
H01L 21/31055 (20130101)
H01L 21/32115 (20130101)
H01L 21/67075 (20130101)
H01L 21/67703 (20130101)
H01L 21/67739 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210313481 Stone et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Stone Aerospace, Inc. (Del Valle, Texas)
ASSIGNEE(S) Stone Aerospace, Inc. (Del Valle, Texas)
INVENTOR(S) William C. Stone (Del Valle, Texas);  Bartholomew P. Hogan (Rockville, Maryland)
ABSTRACT A power conversion module for use with optical energy transfer and conversion system has a hemi-spherically configured housing, an array of photovoltaic chips mounted on the interior thereof, and inlet and outlet ports connected thereto. An end plate connected to the housing defines a cavity. An actively cooled high-power connector has one end connected to a fiber optic cable and the opposite end traversing the end plate and extending within the cavity. Beam forming optics within the cavity are in optical communication with the connector to disburse received optical energy in a hemispherical emission pattern of uniform flux toward an array of photovoltaic chips mounted in complementary configuration to the housing within the cavity, each chip spaced equidistantly from the beam forming optics. A heat sink within the housing has a plurality of fluid channels therethrough through which a work fluid removes heat via the outlet port. In alternative embodiments, the power conversion module includes a housing having a spherical configuration and a plurality of power conversion modules.
FILED Friday, June 18, 2021
APPL NO 17/352019
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/0543 (20141201) Original (OR) Class

Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules
H02S 40/22 (20141201)
H02S 40/42 (20141201)
H02S 40/44 (20141201)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 10/52 (20130101)
Y02E 10/60 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Non-Profit Organization (NPO) 

US 20210308250 Du et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Non-Profit Organization (NPO)
New York Blood Center (NYBC)
APPLICANT(S) New York Blood Center, Inc. (New York, New York);  Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Lanying Du (Rego Park, New York);  Wanbo Tai (Elmhurst, New York);  Fang Li (St. Paul, Minnesota)
ABSTRACT Provided herein are methods of use of subunit immunogenic compositions, in particular for the prevention and treatment of Zika vims infections.
FILED Friday, October 25, 2019
APPL NO 17/287938
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101) Original (OR) Class
A61K 39/39 (20130101)
A61K 2039/55 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309986 PEREZ-PINERA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of General Medical Sciences (NIGMS)
Non-Profit Organization (NPO)
American Heart Association (AHA)
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S) Pablo PEREZ-PINERA (Urbana, Illinois);  Michael P. GAPINSKE (Urbana, Illinois);  Jackson Scott WINTER (Palatine, Illinois)
ABSTRACT The disclosure provides a versatile method termed CRISPR-SKIP that utilizes cytidine and/or adenine deaminase base editors to program exon skipping by mutating target DNA bases within splice acceptor sites and/or splice enhancer sites. Given its simplicity and precision, CRISPR-SKIP will be broadly applicable in gene therapy and synthetic biology
FILED Friday, July 19, 2019
APPL NO 17/260828
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)
A61P 43/00 (20180101)

Peptides
C07K 2319/80 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 9/78 (20130101) Original (OR) Class
C12N 15/11 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)

Enzymes
C12Y 305/04004 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311035 THURMOND
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Non-Profit Organization (NPO)
Juvenile Diabetes Research Foundation (JDRF)
APPLICANT(S) CITY OF HOPE (Duarte, California)
ASSIGNEE(S) CITY OF HOPE (Duarte, California)
INVENTOR(S) Debbie C. THURMOND (Glendora, California)
ABSTRACT Disclosed is the use of DOC2B as an early stage biomarker for diagnosing type 1 diabetes (T1D), pre-T1D, type 2 diabetes (T2D), pre-T2D or for assessing the risk of T1D, pre-T1D, T2D, or pre-T2D. Also disclosed are methods of in vivo diagnosing T1D, pre-T1D, T2D, or pre-T2D or assessing the risk of T1D, pre-T1D, T2D, or pre-T2D by detecting a reduced level of DOC2B expression in a biological sample including blood, plasm, serum, platelets, and pancreatic islets.
FILED Thursday, April 15, 2021
APPL NO 17/231986
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/39 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/543 (20130101) Original (OR) Class
G01N 2333/4703 (20130101)
G01N 2800/042 (20130101)
G01N 2800/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 20210308489 FRIEDMAN
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Integrated Sensors, LLC (Ottawa Hills, Ohio)
ASSIGNEE(S)
INVENTOR(S) Peter S. FRIEDMAN (Ottawa Hills, Ohio)
ABSTRACT Embodiments are directed generally to an ionizing-radiation beamline monitoring system that includes a vacuum chamber structure with vacuum compatible flanges through which an incident ionizing-radiation beam enters the monitoring system. Embodiments further include at least one scintillator within the vacuum chamber structure that can be at least partially translated in the ionizing-radiation beam while oriented at an angle greater than 10 degrees to a normal of the incident ionizing-radiation beam, a machine vision camera coupled to a light-tight structure at atmospheric/ambient pressure that is attached to the vacuum chamber structure by a flange attached to a vacuum-tight viewport window with the camera and lens optical axis oriented at an angle of less than 80 degrees with respect to a normal of the scintillator, and at least one ultraviolet (“UV”) illumination source facing the scintillator in the ionizing-radiation beam for monitoring a scintillator stability comprising scintillator radiation damage.
FILED Thursday, May 27, 2021
APPL NO 17/332047
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/00 (20130101)
A61N 5/1045 (20130101)
A61N 5/1048 (20130101)
A61N 5/1049 (20130101)
A61N 5/1064 (20130101)
A61N 5/1067 (20130101) Original (OR) Class
A61N 2005/1059 (20130101)

Measurement of Nuclear or X-radiation
G01T 1/40 (20130101)
G01T 1/1612 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309778 Bolskar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) TDA Research, Inc. (Wheat Ridge, Colorado)
ASSIGNEE(S)
INVENTOR(S) Robert Donald Bolskar (Arvada, Colorado);  James William Raebiger (Golden, Colorado);  Rhia M. Martin (Arvada, Colorado);  Sylvia DeVito Luebben (Golden, Colorado)
ABSTRACT Crosslink-forming monomers, comprising reverse-acrylate groups, and crosslinked polymer networks formed by the polymerization of monomers that comprise said reverse-acrylate crosslink-forming monomers. Crosslink-forming monomers, comprising reverse-acrylate groups, comprising an alkyl, an aryl, an alkoxyl, and an alkylamino group bridging one or more reverse-acrylate groups. Crosslink-forming monomers, comprising reverse-acrylate groups, comprising an alkyl, an aryl, an alkoxyl, and an alkylamino ester groups. Crosslink-forming monomers, comprising reverse-acrylate groups, comprising alkyl groups where the group is selected from the group consisting of a methyl, an ethyl, a propyl, an n-butyl and a t-butyl. Reverse-acrylate crosslink-forming monomers comprise a chemical structure where the two or more polymerizable carbon-carbon double bonds are connected by a crosslinking group on the opposite side of the hydrolysable ester groups relative to normal crosslinking acrylate monomers. The crosslink-forming monomers herein form crosslinked polymer networks that do not lose their crosslinking upon hydrolysis of the ester linkages.
FILED Tuesday, March 16, 2021
APPL NO 17/203648
CURRENT CPC
Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 222/1025 (20200201) Original (OR) Class
C08F 2438/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210310881 Diehn et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Prasidiux, LLC (Arlington, Virginia)
ASSIGNEE(S) Prasidiux, LLC (Arlington, Virginia)
INVENTOR(S) Kevin K. Diehn (Towson, Maryland);  Bani H. Cipriano (Rockville, Maryland);  Rel S. Ambrozy (Arlington, Virginia)
ABSTRACT A new and useful thermochromic liquid crystal Indicator is disclosed that provides an indication of the temperature of the Object to which the Indicator is attached, and is an improvement over the existing art for at least the fact that the impact of ambient air circulating around the Indicator and circulating the Object is reduced by several means, such as i) the use of a novel cap or housing to isolate the liquid crystal Structure from ambient air and from touching or ii) using a novel liquid crystal formulation that reduces the reaction time of the thermochromic liquid crystal contained in the Indicator to changing temperatures conveyed by the ambient air. The new and useful liquid crystal Indicator can also employ either a template or a colored filter as a mask that narrows the colors and narrows the range of temperatures indicated by the Indicator.
FILED Friday, June 18, 2021
APPL NO 17/351466
CURRENT CPC
Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for
G01K 1/08 (20130101)
G01K 11/12 (20130101)
G01K 11/165 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Commerce (DOC) 

US 20210311119 Bienfang
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)
INVENTOR(S) Joshua Copeland Bienfang (Bethesda, Maryland)
ABSTRACT A temporal jitter analyzer analyzes temporal jitter and includes: a time delay controller; a time delay member; a delay measurement circuit; an edge generator in communication with the time delay member and that receives the delayed primary signal from the time delay member and produces a reference signal from the delayed primary signal; a decision circuit in communication with the edge generator and that: receives the reference signal from the edge generator; receives a detector signal; and produces a raw decision signal from the detector signal such that a value of the raw decision signal depends on the reference signal; and a decision circuit readout in communication with the edge generator and the decision circuit and that: receives the reference signal from the edge generator; receives the raw decision signal from the decision circuit; and produces a decision signal from the raw decision signal based on the reference signal.
FILED Tuesday, April 06, 2021
APPL NO 17/223554
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/31709 (20130101) Original (OR) Class
G01R 31/31727 (20130101)

Pulse Technique
H03K 5/133 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210311146 Keenan et al.
FUNDED BY
Department of Commerce (DOC)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio);  Government of the United States, as represented by the Secretary of Commerce (Gaithersburg, Maryland);  The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Kathryn Keenan (Boulder, Colorado);  Megan Poorman (Boulder, Colorado);  Rasim Boyacioglu (Cleveland Heights, Ohio);  Mark A. Griswold (Shaker Heights, Ohio)
ABSTRACT A method for temperature quantification using magnetic resonance fingerprinting (MRF) includes acquiring MRF data from a region of interest in a subject using an MRF pulse sequence with smoothly varying RF phase for MR resonant frequencies that is played out continuously. For each of a plurality of time intervals during acquisition of the MRF data the method further includes comparing a set of the MRF data associated with the time interval to an MRF dictionary to determine at least one quantitative parameter of the acquired MRF data, determining a temperature change based on the at least one quantitative parameter and generating a quantitative map of the temperature change in the region of interest. The region of interest can include aqueous and adipose tissue.
FILED Monday, April 05, 2021
APPL NO 17/301509
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0037 (20130101)
A61B 5/055 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/50 (20130101) Original (OR) Class
G01R 33/385 (20130101)
G01R 33/5608 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Homeland Security (DHS) 

US 20210311067 TONG
FUNDED BY
Department of Homeland Security (DHS)
Science and Technology Directorate (DHS-S&T)
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
APPLICANT(S) SAN DIEGO STATE UNIVERSITY FOUNDATION (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) William G. TONG (La Jolla, California)
ABSTRACT This patent document discloses techniques, systems, and devices for detecting a target substance using optical nonlinear wave mixing for enhanced detection sensitivity and accuracy. In one aspect, a method for measuring α-synuclein in a body fluid of a patient with high detection sensitivity and accuracy and providing early stage Parkinson's disease detection is provided. The method may comprise: supplying to a capillary analyte cell a fluidic sample that includes a body fluid of a patient containing α-synuclein, wherein the capillary analyte cell is located in a nonlinear optical four-wave mixing device; directing laser light from the nonlinear optical four-wave mixing device into the capillary analyte cell to cause nonlinear optical four-wave mixing in the fluidic sample to generate a four-wave mixing signal that contains information on the α-synuclein in the fluidic sample; and processing the four-wave mixing signal to extract information on the α-synuclein in the fluidic sample.
FILED Tuesday, February 21, 2017
APPL NO 15/999856
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502715 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/03 (20130101)
G01N 21/636 (20130101)
G01N 21/718 (20130101)
G01N 27/44791 (20130101)
G01N 33/49 (20130101)
G01N 33/582 (20130101) Original (OR) Class
G01N 33/6896 (20130101)
G01N 2021/0346 (20130101)
G01N 2800/56 (20130101)
G01N 2800/2835 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210312201 Hastings et al.
FUNDED BY
Department of Homeland Security (DHS)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S) William Hastings (Alexandria, Virginia);  James Gilkeson (Alexandria, Virginia);  Douglas MacIvor (Arlington, Virginia)
ABSTRACT Various embodiments are directed toward systems and methods relating to security screening. For example, a screening system includes chamber scanners oriented to scan different heights corresponding to different respective portions of a user, to identify whether the user is carrying an item that is to be divested. The screening system also includes a divestment scanner configured to obtain a detailed item characterization of the item divested from the user.
FILED Thursday, January 28, 2021
APPL NO 17/161220
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 23/10 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/209 (20130101) Original (OR) Class
G06K 9/6288 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/20 (20130101)

Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere
G07C 9/15 (20200101)
G07C 9/32 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 20210307585 Hillson et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Larry Hillson (Reno, Nevada);  Micah Hambleton (Sparks, Nevada)
ABSTRACT A cleaning cart can comprise a body defining an underside and at least one shelf, wherein the body has a footprint. A plurality of wheels can rotatably couple to the body. A sweeping attachment can be coupled to the underside of the body. The sweeping attachment can comprise a slide comprising a track that is coupled to the body and a carriage that is configured to slide relative to the track along an axis about and between a first position that is generally within the footprint of the body and a second position that is generally outside of the footprint of the body. A sweeping assembly can be coupled to the carriage. The sweeping assembly can couple to a sweeping element.
FILED Thursday, April 01, 2021
APPL NO 17/220352
CURRENT CPC
Domestic Washing or Cleaning; Suction Cleaners in General
A47L 13/38 (20130101) Original (OR) Class
A47L 13/42 (20130101)

Hand-propelled Vehicles, e.g Hand Carts or Perambulators; Sledges
B62B 3/02 (20130101)
B62B 3/005 (20130101)
B62B 2202/50 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20210309618 WEMPE et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate (Denver, Colorado);  NATIONAL JEWISH HEALTH (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Michael Fitzpatrick WEMPE (Aurora, Colorado);  Andres VAZQUEZ-TORRES (Denver, Colorado);  Shaodong DAI (Englewood, Colorado)
ABSTRACT The present invention relates to the discovery of novel N-(substituted)-1H-1,2,4-triazole-3-carboxamide compounds capable of inhibiting DksA activity in a bacteria cell. In certain embodiments, the compounds are capable of killing or weakening bacteria. In another aspect, the invention relates to methods of treating bacterial infection in a subject in need thereof, the method comprising administering to the subject a compound of the invention.
FILED Thursday, August 22, 2019
APPL NO 17/269725
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations