FedInvent™ Patent Applications
Application Details for Thursday, October 14, 2021
This page was updated on Friday, October 15, 2021 at 02:24 PM GMT
Department of Health and Human Services (HHS)
| US 20210315486 | Delp et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Gillette Children's Specialty Healthcare (St. Paul, Minnesota) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Gillette Children's Specialty Healthcare (St. Paul, Minnesota) |
| INVENTOR(S) | Scott Delp (Stanford, California); Lukasz Kidzinski (Palo Alto, California); Bryan Yang (San Jose, California); Michael Schwartz (Minneapolis, Minnesota); Jennifer Lee Hicks (Fremont, California) |
| ABSTRACT | Systems and methods in accordance with many embodiments of the invention include a motion evaluation system that trains a model to evaluate motion (such as, but not limited to, gait) through images (or video) captured by a single image capture device. In certain embodiments, motion evaluation includes predicting clinically relevant variables from videos of patients walking from keypoint trajectories extracted from the captured images. |
| FILED | Monday, July 15, 2019 |
| APPL NO | 17/260970 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/112 (20130101) Original (OR) Class A61B 5/1128 (20130101) A61B 5/4082 (20130101) A61B 5/7267 (20130101) A61B 2576/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315558 | Rafiee et al. |
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| FUNDED BY |
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| APPLICANT(S) | Transmural Systems LLC (Andover, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nasser Rafiee (Andover, Massachusetts); Stuart MacDonald (Andover, Massachusetts); Rany Busold (Andover, Massachusetts); Koosha Rafiee (Andover, Massachusetts) |
| ABSTRACT | The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 17/356453 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/0057 (20130101) Original (OR) Class A61B 17/1215 (20130101) A61B 17/12031 (20130101) A61B 17/12122 (20130101) A61B 17/12145 (20130101) A61B 2017/00243 (20130101) A61B 2017/00557 (20130101) A61B 2017/00575 (20130101) A61B 2017/00592 (20130101) A61B 2017/00597 (20130101) A61B 2017/00964 (20130101) A61B 2090/3966 (20160201) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/0077 (20130101) A61F 2/88 (20130101) A61F 2/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315594 | Kallmes et al. |
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| FUNDED BY |
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| APPLICANT(S) | Marblehead Medical, LLC (Rochester, Minnesota); Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David F. Kallmes (Rochester, Minnesota); Waleed Brinjikji (Rochester, Minnesota); Brady Hatcher (Rogers, Minnesota); Randy Beyreis (Rogers, Minnesota) |
| ABSTRACT | A balloon guiding sheath may include an elongated sheath comprising a proximal end, a distal end, an inner tube, an outer tube surrounding the inner tube, an access port, a distal port, and a working lumen extending through an interior portion of the elongated sheath between the access port and the distal port. The balloon guiding sheath may also include an inflatable balloon located on an outer surface of the elongated sheath adjacent the distal end. The balloon guiding sheath may include a plurality of inflation holes extending through a side wall of the elongated sheath. The elongated sheath may be sized and configured to enable direct insertion into a patient's vasculature through an arteriotomy in at least one of a femoral artery and vertebral artery to position the inflatable balloon at a target site. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222392 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/22 (20130101) Original (OR) Class A61B 2017/22065 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/1018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315814 | Lu et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Quan Lu (Cambridge, Massachusetts); Joseph F. Nabhan (Cambridge, Massachusetts); Stanley N. Cohen (Palo Alto, California) |
| ABSTRACT | The invention provide isolated arrestin domain-containing protein 1 (ARRDC1)-mediated microvesicles (ARMMs). Methods for generating and for isolating ARMMs are also provided herein. ARMMs can be used to deliver agents, for example, nucleic acids (e.g., siRNAs, microRNAs, lincRNAs), proteins (e.g., transcription factors, chromatin modulators, kinases, phosphorylases, or recombinases), or small molecules to target cells in vitro and in vivo, and methods for such ARMM-mediated delivery are provided herein. Diagnostic and therapeutic methods using ARMMs are also described herein. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168988 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/107 (20130101) Original (OR) Class A61K 47/42 (20130101) Peptides C07K 14/47 (20130101) C07K 2319/00 (20130101) C07K 2319/70 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/47 (20130101) G01N 2333/726 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315816 | Kielian et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
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| INVENTOR(S) | Tammy Kielian (La Vista, Nebraska); Tatiana Bronich (Elkhorn, Nebraska); Kelsey Yamada (Omaha, Nebraska); Xinyuan Xi (Omaha, Nebraska) |
| ABSTRACT | The present invention provides compositions and methods for the inhibition of a bacterial infection. More specifically, the present invention relates to compositions and methods for the inhibition and/or treatment of a bacterial infection, particularly an infection characterized by a biofilm. In a particular embodiment, the micelle comprises at least one block copolymer comprising an ionically charged polymeric segment and a non-ionically charged polymeric segment, wherein the ionically charged polymeric segment is grafted with hydrophobic moieties |
| FILED | Thursday, September 12, 2019 |
| APPL NO | 17/261074 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Original (OR) Class A61K 31/365 (20130101) A61K 45/06 (20130101) A61K 47/66 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315821 | Migrino et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
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| INVENTOR(S) | Raymond Q. Migrino (Phoenix, Arizona); Seth Truran (Pheonix, Arizona); Nina Karamanova (Laveen, Arizona); Volkmar Weissig (Glendale, Arizona); Jillian Madine (Liverpool, United Kingdom); Hannah Davies (Liverpool, United Kingdom) |
| ABSTRACT | Disclosed herein are compositions comprising nanoliposomes useful for the treatment and prevention of cerebrovascular and aging-related degenerative diseases. |
| FILED | Friday, August 09, 2019 |
| APPL NO | 17/267738 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/1272 (20130101) Original (OR) Class A61K 38/1709 (20130101) A61K 47/24 (20130101) A61K 47/26 (20130101) A61K 47/28 (20130101) A61K 47/6849 (20170801) A61K 47/6913 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/586 (20130101) G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315868 | GEISSMANN et al. |
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| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Frederic GEISSMANN (New York, New York); Elvira MASS (New York, New York); Rocio VICARIO (New York, New York) |
| ABSTRACT | The present technology relates to methods for treating, preventing, and/or ameliorating kinase mutation-associated neurodegenerative diseases, including BRAFV600E-associated neurodegenerative diseases, in a subject in need thereof. In particular aspects, the present technology relates to the use of BRAF, MEK, and/or CSF-IR inhibitors to treat, prevent, and/or ameliorate kinase mutation-associated neurodegenerative diseases, including BRAFV600E-associated neurodegenerative diseases. |
| FILED | Friday, August 24, 2018 |
| APPL NO | 16/640146 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315878 | JORDAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, A Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig JORDAN (Aurora, Colorado); Clayton SMITH (Aurora, Colorado); Courtney L. JONES (Aurora, Colorado); Brett STEVENS (Aurora, Colorado) |
| ABSTRACT | The present disclosure relates to compositions and methods for reducing cancer stem cells. In some aspects, the compositions and methods can comprise at least one metabolism modulating agent. In other aspects, the compositions and methods can comprise at least two metabolism modulating agents. |
| FILED | Tuesday, October 15, 2019 |
| APPL NO | 17/284545 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/336 (20130101) A61K 31/635 (20130101) A61K 31/706 (20130101) A61K 31/4545 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315886 | HERGENROTHER et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Paul J. HERGENROTHER (Champaign, Illinois); Timothy M. FAN (Mahomet, Illinois); Riley L. SVEC (Urbana, Illinois) |
| ABSTRACT | New synthetic methods to provide access to previously unexplored functionality at the C8 position of imidazotetrazines. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM. |
| FILED | Friday, August 09, 2019 |
| APPL NO | 17/266770 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/495 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315894 | Gray et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts) |
| ABSTRACT | The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., lung cancer, breast cancer, leukemia, lymphoma, melanoma, multiple myeloma, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase (e.g. a protein kinase (e.g. a cyclin-dependent kinase (CDK) (e.g. CDK7, CDK12, or CDK13) or a lipid kinase such as a phosphatidylinositol-5-phosphate 4-kinase (PIP4K) (e.g., PI5P4Kα, PI5P4Kβ, or PI5P4Kγ)) in the subject. |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 16/899412 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/497 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Heterocyclic Compounds C07D 401/04 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/04 (20130101) C07D 407/04 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315895 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Beibei Chen (Sewickley, Pennsylvania); Rama K. Mallampalli (Sewickley, Pennsylvania) |
| ABSTRACT | A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; and R1-R10 are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R3 or R8 is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 16/953201 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 31/341 (20130101) A61K 31/381 (20130101) A61K 31/402 (20130101) A61K 31/427 (20130101) A61K 31/435 (20130101) A61K 31/444 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/4178 (20130101) A61K 31/4418 (20130101) A61K 31/5375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 11/06 (20180101) A61P 19/00 (20180101) A61P 25/00 (20180101) A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 211/01 (20130101) C07C 211/53 (20130101) C07C 229/38 (20130101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 211/14 (20130101) C07D 213/06 (20130101) C07D 213/36 (20130101) C07D 213/38 (20130101) C07D 231/12 (20130101) C07D 233/61 (20130101) C07D 233/64 (20130101) C07D 239/26 (20130101) C07D 265/30 (20130101) C07D 277/28 (20130101) C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315902 | TENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Forge Therapeutics, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min TENG (San Diego, California); Baskar NAMMALWAR (San Diego, California); David T. PUERTA (San Diego, California) |
| ABSTRACT | Provided herein is an LpxC inhibitor compound, as well as pharmaceutical compositions comprising said compound, and methods of use thereof in the treatment of disease that would benefit from treatment with an LpxC inhibitor, including gram-negative bacterial infections such as urinary tract infections and the like. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/211025 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/5377 (20130101) Original (OR) Class A61K 47/38 (20130101) A61K 47/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315906 | Quave et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cassandra L. Quave (Atlanta, Georgia); James Lyles (Sandy Springs, Georgia); Gina Porras-Brenes (Atlanta, Georgia); Huaqiao Tang (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a Schinus plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357353 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/569 (20130101) Original (OR) Class A61K 36/22 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315914 | ALBERINI et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cristina Maria ALBERINI (New York, New York); Dirk TRAUNER (New York, New York); Christopher James ARP (The Woodlands, Texas) |
| ABSTRACT | Provided are methods for treatment of neurodevelopmental disorders, such as Angelman Syndrome and autism comprising administering to an individual a composition comprising an agonist ligand of IGF-2 receptor. The agonist ligand of IGF-2 receptor may be IGF-2, or mannose-6-phosphate or a derivative thereof. Compositions comprising mannose-6-phosphate derivatives are also disclosed. |
| FILED | Monday, August 12, 2019 |
| APPL NO | 17/267715 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7024 (20130101) Original (OR) Class A61K 38/30 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315947 | Lynch et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan Lynch (Piedmont, California); Nikole Kimes (San Francisco, California); Din Lin (San Francisco, California); Ricardo Valladares (San Francisco, California); Kei Fujimura (San Francisco, California) |
| ABSTRACT | Provided herein are, inter alia, microbial compositions and methods of using the same. The microbial compositions provided include, inter alia, therapeutically effective amounts of Lactobacillus johnsonii, Faecalibacterium prausnitzii, Akkermansia muciniphila, Myxococcus xanthus and Pediococcus pentosaceus and are particularly useful for methods of treating and preventing inflammatory diseases. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/233194 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/065 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0031 (20130101) A61K 9/0053 (20130101) A61K 35/745 (20130101) Original (OR) Class A61K 35/747 (20130101) A61K 39/02 (20130101) A61K 39/0008 (20130101) A61K 39/35 (20130101) A61K 2035/11 (20130101) A61K 2039/58 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315964 | Fisher et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aron B. Fisher (Philadelphia, Pennsylvania); Sheldon I. Feinstein (Philadelphia, Pennsylvania) |
| ABSTRACT | In various aspects and embodiments the invention provides compositions and methods useful in the treatment of acute lung injury (ALI). |
| FILED | Thursday, August 15, 2019 |
| APPL NO | 17/269097 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) Original (OR) Class A61K 38/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315968 | MA et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRIM-edicine, Inc. (Columbus, Ohio) |
| ASSIGNEE(S) | OHIO STATE INNOVATION FOUNDATION (COLUMBUS, Ohio) |
| INVENTOR(S) | JIANJIE MA (POWELL, Ohio); JACOB S. YOUNT (COLUMBUS, Ohio); MATTHEW A. SERMERSHEIM (NASHVILLE, Tennessee); ADAM D. KENNEY (COLUMBUS, Ohio); Xinyu ZHOU (HILLIARD, Ohio); BRYAN A. WHITSON (WESTERVILLE, Ohio); NAHUSH A. MOKADAM (UPPER ARLINGTON, Ohio); TAO TAN (COLUMBUS, Ohio); CHUANXI CAI (POWELL, Ohio) |
| ABSTRACT | Compositions for and methods of preventing, reversing or treating viral infection-induced organ failure provided. The compositions are also suitable for treating and/or preventing COVID-19 and influenza. The compositions and methods employ MG53, which can be in the form of recombinant human MG53. The MG53 may also be administered as a composition that expresses and releases MG53 after in vivo administration of said composition to a subject. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/184781 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315971 | EARLEY |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents of the Nevada System of Higher Education on behalf of the University of Nevada,Reno (Reno, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yumei Feng EARLEY (Reno, Nevada) |
| ABSTRACT | Disclosed are methods of treating metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), and Type II diabetes. In some examples, the method includes administration of an effective amount of a (pro)renin receptor (PRR) antagonist to a subject in need thereof, such as a patient at risk of acquiring or afflicted with NAFLD, NASH and/or Type II diabetes, to prevent, inhibit, and/or reduce one or more signs or symptoms associated with NAFLD, NASH and/or Type II diabetes, such as by reducing the severity of liver steatosis. |
| FILED | Tuesday, August 06, 2019 |
| APPL NO | 17/265497 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1796 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315972 | Stupp et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel I. Stupp (Chicago, Illinois); Mark Trosper McClendon (Chicago, Illinois); Guifa Xi (Chicago, Illinois); Bo Timmy Bjoern Fyrner (Kopparberg, Sweden); Cara S. Smith (Chicago, Illinois); Nicholas A. Sather (Evanston, Illinois) |
| ABSTRACT | Provided herein are compositions comprising peptide amphiphiles, glycosylated peptide amphiphiles (GPAs), supramolecular nanostructures assembled therefrom, and methods of use thereof. The peptide amphiphiles described herein may extend the half-life of bone morphogenic proteins, promote cell differentiation, suppress proliferation, and increase chemosensitivity of cells. Accordingly, the compositions described herein may be used for cancer treatment methods. In particular, provided herein are bone morphogenic proteins bound to peptide amphiphiles and glycosylated peptide amphiphiles or composites thereof, and methods of use of the same for the treatment of cancer. Also, provided herein are bone morphogenic proteins bound to peptide amphiphiles and glycosylated peptide amphiphiles or composites thereof, and methods of use of the same in a combinatorial approach together with chemotherapeutic medications for the treatment of cancer. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/227943 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1875 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/61 (20170801) A61K 47/549 (20170801) A61K 47/641 (20170801) A61K 47/645 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315974 | MCLAUGHLIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tracey L. MCLAUGHLIN (Stanford, California); Colleen M. CRAIG (Stanford, California) |
| ABSTRACT | Compositions and methods for treating hyperinsulinemic hypoglycemia, such as hyperinsulinemic hypoglycemia after bariatric surgery, are provided. In some embodiments, an effective amount of the glucagon-like peptide-1 receptor antagonist exendin(9-39) is subcutaneously administered twice per day. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226164 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/10 (20130101) A61K 9/0019 (20130101) A61K 38/17 (20130101) A61K 38/22 (20130101) A61K 38/26 (20130101) A61K 38/2278 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315980 | Brinton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia State University Research Foundation, Inc. (Atlanta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Margo A. Brinton (Atlanta, Georgia); Joseph C. Madden, Jr. (Atlanta, Georgia); Philip J. Santangelo (Atlanta, Georgia) |
| ABSTRACT | The present invention provides a method for treating, and compositions useful for treating, Flavivirus infections in a human by administering to the human an effective amount of mRNA encoding Mus musculus resistant 2′-5′ oligoadenylate synthetase 1b (rOas1b), or variants thereof. |
| FILED | Wednesday, August 21, 2019 |
| APPL NO | 17/269968 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) Original (OR) Class A61K 47/18 (20130101) A61K 47/24 (20130101) A61K 48/0066 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315985 | Perera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Washington, District of Columbia); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Liyanage Parakrama Perera (Bethesda, Maryland); Thomas Alexander Waldmann (Bethesda, Maryland); Kevin Charles Conlon (Bethesda, Maryland); Pin-Yu Perera (Washington, District of Columbia) |
| ABSTRACT | A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353054 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) A61K 31/7076 (20130101) A61K 35/17 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 16/2866 (20130101) C07K 2317/24 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315990 | Gill et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harvinder Singh Gill (Lubbock, Texas); Akhilesh Kumar Shakya (Lubbock, Texas) |
| ABSTRACT | Methods and devices are provided for treating a food allergy in a subject in need thereof. The method entails delivering an effective amount of an allergen associated with the food allergy into the subject's cutis skin layer. Delivering the allergen is carried out by inserting one or more allergen-coated solid microneedles into the subject's skin. The one or more solid microneedles each has a base, shaft and tip, and when inserted in the subject, do not extend beyond the cutis. The allergen is allowed to dissociate from the one or more microneedles while inserted in the subject's cutis. Once the allergen disassociates, the one or more microneedles is removed from the subject's skin. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354099 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) A61K 39/35 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/54 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315992 | Beutler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce Beutler (lrving, Texas); Ying Wang (Dallas, Texas) |
| ABSTRACT | A potent human and mouse Toll-like receptor (TLR)1/TLR2 agonist was identified and optimized, Diprovocim, which exhibited an EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages. In mice, Diprovocim-adjuvanted ovalbumin immunization promoted antigen-specific humoral and CTL responses, and synergized with anti-PD-L1 treatment to inhibit tumor growth, generating long-term anti-tumor memory, curing or prolonging survival of mice engrafted with the murine melanoma B16-OVA. Diprovocim induced greater frequencies of tumor infiltrating leukocytes than alum, of which CD8 T cells were necessary for the antitumor effect of immunization plus anti-PD-L1 treatment. |
| FILED | Wednesday, July 31, 2019 |
| APPL NO | 17/265333 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 39/00118 (20180801) A61K 39/145 (20130101) A61K 39/001106 (20180801) A61K 39/001118 (20180801) A61K 39/001121 (20180801) A61K 39/001124 (20180801) A61K 39/001128 (20180801) A61K 39/001129 (20180801) A61K 39/001131 (20180801) A61K 39/001158 (20180801) A61K 39/001159 (20180801) A61K 39/001166 (20180801) A61K 39/001174 (20180801) A61K 2039/55511 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316007 | Yousefpour et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Parisa Yousefpour (Durham, North Carolina); Ashutosh Chilkoti (Durham, North Carolina) |
| ABSTRACT | Described herein are compositions that include an assembly of self-assembling conjugates. The self-assembling conjugates may include a polypeptide having a transition temperature (17) above 50° C. when the polypeptide is not attached to the conjugate, an albumin binding domain (ABD) attached to a first end of the polypeptide, and at least one molecule attached to a second end of the polypeptide through a cysteine group, wherein the molecule has an octanol-water distribution coefficient (log D) of greater than or equal to 1.5 at a pH of 7.4 when the molecule is not attached to the conjugate. Also described herein are methods of using the compositions. |
| FILED | Friday, September 06, 2019 |
| APPL NO | 17/272887 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) A61K 47/6907 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316015 | Chaudhry |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hina W. Chaudhry (New York, New York) |
| ABSTRACT | The disclosure relates to compositions and methods for promoting cardiomyocyte cytokinesis and cardiomyocyte proliferation and for use in cardiac regenerative therapy. Embodiments of the disclosure are particularly useful for promoting cytokinesis in adult cardiomyocytes. In embodiments, the disclosure relates to the expression of human cyclin A2 (CCNA2) under the control of a cardiac Troponin T (cTNT) promoter to promote cytokinesis of adult human cardiomyocytes. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 17/273805 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0029 (20130101) A61K 35/34 (20130101) A61K 38/18 (20130101) A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2750/00043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316016 | MILLETTE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MATTHEW MICHAEL MILLETTE (MIDDLETON, Wisconsin); ERIK WOLFE DENT (MADISON, Wisconsin) |
| ABSTRACT | An expression cassette for gene silencing and replacement, including, in operable communication, a promoter, an expression attenuator, a nucleotide sequence encoding a gene for a replacement target protein, and an shRNA sequence for knockdown of an endogenous variant of the target protein, wherein the promoter, the expression attenuator, the nucleotide sequence encoding the gene for the replacement target protein, and the shRNA are expressed as a single transcript. Also included are expression vectors and cells. Also included are methods of silencing and replacement of a target gene in a cell in culture by transforming the cells with the expression vectors described herein. Also included are minimal expression cassettes suitable for therapeutic methods. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/346639 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0008 (20130101) A61K 48/0058 (20130101) A61K 48/0066 (20130101) Original (OR) Class A61K 48/0091 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316044 | Zlotnick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hannah M. Zlotnick (Philadelphia, Pennsylvania); Andrew Todd Clark (North Wales, Pennsylvania); Robert L. Mauck (Philadelphia, Pennsylvania); Xuemei Cheng (Bryn Mawr, Pennsylvania) |
| ABSTRACT | The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229829 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/042 (20130101) A61L 27/045 (20130101) A61L 27/46 (20130101) A61L 27/047 (20130101) A61L 27/52 (20130101) A61L 27/222 (20130101) A61L 27/225 (20130101) A61L 27/3847 (20130101) Original (OR) Class A61L 27/3852 (20130101) A61L 2300/41 (20130101) A61L 2300/43 (20130101) A61L 2300/258 (20130101) A61L 2300/402 (20130101) A61L 2300/406 (20130101) A61L 2300/408 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316116 | Kallmes et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marblehead Medical, LLC (Rochester, Minnesota); Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David F. Kallmes (Rochester, Minnesota); Waleed Brinjikji (Rochester, Minnesota); Brady Hatcher (Rogers, Minnesota); Randy Beyreis (Rogers, Minnesota) |
| ABSTRACT | A balloon guiding sheath may include an elongated sheath comprising a proximal end, a distal end, an inner tube, an outer tube surrounding the inner tube, an access port located adjacent the proximal end, a distal port located adjacent the distal end, and a working lumen extending between the access port and the distal port. The balloon guiding sheath may also include an inflatable balloon located on an outer surface of the elongated sheath adjacent the distal end. The balloon guiding sheath may also include a textured surface located along an outer portion of the outer tube and located beneath the inflatable balloon. The elongated sheath may be sized and configured to enable direct insertion into vasculature of a patient through an arteriotomy in at least one of a carotid artery or a vertebral artery to position the inflatable balloon at a target site. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222798 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0043 (20130101) A61M 25/0122 (20130101) A61M 25/0155 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316144 | Ganguly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karunesh Ganguly (San Francisco, California); Tanuj Gulati (San Francisco, California); Dhakshin S. Ramanathan (San Diego, California) |
| ABSTRACT | Systems, methods and devices for promoting recovery from a stroke induced loss of motor function in a subject. In certain aspects, the system includes at least one electrode, and an operations system in electrical communication with at least one electrode, wherein the at least one electrode is constructed and arranged to apply current across the brain of the subject and to record low frequency oscillations from a perilesional region of the subject. In certain aspects, provided is a method comprising placing at least one recording electrode in electrical communication in a perilesional region of the subject; placing at least one stimulation electrode in electrical communication with the brain of the subject; recording low frequency oscillations from the perilesional region of the subject; and delivering current stimulation to the brain of the subject. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/259760 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/313 (20210101) A61B 5/4836 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0531 (20130101) A61N 1/36103 (20130101) Original (OR) Class A61N 1/36171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316498 | Kaplan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Medford, Massachusetts); Xuan Mu (Medford, Massachusetts) |
| ABSTRACT | Three-dimensional printing methods and systems for forming a three-dimensional protein article are disclosed. The methods and systems involve selecting article formation parameters, such as protein ink parameters, solvent bath parameters, shear force parameters, and mapping parameters. After these parameters are selected, the methods and systems iteratively introduce protein ink into a solvent bath via a three-dimensional printing outlet. The result is a three-dimensional protein article. One exemplary protein is silk fibroin. Further processing can be done, such as drying the article. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269582 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/30 (20170801) B29C 64/106 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2089/00 (20130101) B29K 2105/0032 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) B33Y 70/00 (20141201) Peptides C07K 14/43586 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0605 (20130101) C12N 2533/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317067 | Swerdlow et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell Swerdlow (Leawood, Kansas); Laird Forrest (Lawrence, Kansas); Jordan Hunt (Lawrence, Kansas); Heather Wilkins (Kansas City, Kansas); Eli Michaelis (Lawrence, Kansas) |
| ABSTRACT | Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and com positions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy. |
| FILED | Monday, September 30, 2019 |
| APPL NO | 17/280235 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Acyclic or Carbocyclic Compounds C07C 69/716 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317074 | FENG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan FENG (Shanghai, China PRC); Mauro FA (Brooklyn, New York); Ottavio ARANCIO (New York, New York); Shixian DENG (White Plains, New York); Donald W. LANDRY (New York, New York); Yitshak FRANCIS (New York, New York) |
| ABSTRACT | The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317133 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/00 (20130101) Acyclic or Carbocyclic Compounds C07C 235/56 (20130101) C07C 235/64 (20130101) Original (OR) Class C07C 237/40 (20130101) C07C 323/42 (20130101) C07C 323/44 (20130101) C07C 323/60 (20130101) C07C 323/67 (20130101) C07C 2601/08 (20170501) Heterocyclic Compounds C07D 213/75 (20130101) C07D 213/82 (20130101) C07D 239/52 (20130101) C07D 333/38 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/48 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2500/04 (20130101) G01N 2800/2814 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317093 | Pierce et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua G. Pierce (Raleigh, North Carolina); Grant A. Edwards (Raleigh, North Carolina) |
| ABSTRACT | Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biofilms. The compounds can also exhibit activity against Gram negative biofilms. In some cases, the compounds can exhibit both biofilm modulation properties and antimicrobial activity. Compositions comprising these compounds, as well as methods of using thereof, are also described. For example, the compounds described herein can be used in human and animal health (e.g., for the treatment of infection), agriculture, marine coatings, and other coating applications related to prevention of biofilm (e.g., dental, medical, etc.). |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/087486 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/76 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 29/16 (20130101) A61L 31/08 (20130101) A61L 31/16 (20130101) A61L 2300/204 (20130101) A61L 2300/404 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 263/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317095 | CUERVO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ana Maria CUERVO (Bronx, New York); Evripidis GAVATHIOTIS (Bronx, New York) |
| ABSTRACT | Compounds and pharmaceutically acceptable salts thereof of Formula I are disclosed. Certain compounds and salts of Formula I are active as CMA modulators. The disclosure provides pharmaceutical compositions containing a compound of Formula I. |
| FILED | Thursday, August 30, 2018 |
| APPL NO | 17/270522 |
| CURRENT CPC | Heterocyclic Compounds C07D 241/42 (20130101) C07D 265/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317106 | Pathak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Southern Research Institute (Birmingham, Alabama); Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashish Kumar Pathak (Birmingham, Alabama); Corinne E. Augelli-Szafran (Homewood, Alabama); Atefeh Garzan (Hoover, Alabama); Daniel Steblow (Banks, Oregon); Nicole Haese (Beaverton, Oregon) |
| ABSTRACT | The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/221666 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/69 (20130101) C07D 213/70 (20130101) C07D 213/74 (20130101) C07D 403/04 (20130101) Original (OR) Class C07D 491/052 (20130101) C07D 498/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317117 | Miller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Courtney Miller (Jupiter, Florida); Patrick R. Griffin (Jupiter, Florida); Theodore Mark Kamenecka (Palm Beach Gardens, Florida); Gavin Rumbaugh (Jupiter, Florida); Matthew Surman (Albany, New York); Steve Young (Lansdale, Pennsylvania); Steven Duddy (Ann Arbor, Michigan); Laszlo Radnai (East Palm Beach Gardens, Florida) |
| ABSTRACT | The invention can provide compounds, analogs of blebbistatin, effective and selective inhibitors of nonmuscle myosin II relative to cardiac myosin II. Compounds can be used in the method of treating a disease, disorder, or medical condition in a patient, comprising modulating myosin II ATPase, such as treatment of substance abuse relapse disorder, or of renal disease, cancer and metastasis, benign prostate hyperplasia, hemostasis or thrombosis, nerve injury including retinal damage, lung fibrosis, liver fibrosis, arthrofibrosis, wound healing, spinal cord injury, periodontitis, glaucoma and immune-related diseases including multiple sclerosis; or wherein the disease, disorder, or medical condition comprises addiction including abuse of or addiction to anything classified as a Substance-Related or Addictive Disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM), such as, but not limited to, cocaine, opioids, amphetamines, ethanol, cannabis/marijuana, nicotine, and activities including gambling Compounds are of general formula (I) with substituents as defined herein. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 17/250203 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 471/14 (20130101) C07D 495/14 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317132 | Markowitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford Markowitz (Pepper Pike, Ohio); Monika Antczak (Fort Worth, Texas); Joseph Ready (Carrollton, Texas); Youngyou Zhang (Cleveland, Ohio) |
| ABSTRACT | Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein. |
| FILED | Tuesday, May 29, 2018 |
| APPL NO | 16/617137 |
| CURRENT CPC | Heterocyclic Compounds C07D 495/04 (20130101) Original (OR) Class C07D 495/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317137 | Gibbs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| INVENTOR(S) | Summer L. Gibbs (Westlinn, Oregon); Lei G. Wang (Portland, Oregon); Connor W. Barth (Portland, Oregon) |
| ABSTRACT | Provided are far red to near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures. |
| FILED | Friday, July 26, 2019 |
| APPL NO | 17/263863 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0028 (20130101) Heterocyclic Compounds C07D 498/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317143 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremiah A. Johnson (Boston, Massachusetts); Paiman Ghoroghchian (Boston, Massachusetts); Yivan Jiang (Revere, Massachusetts); Hung Vanthanh Nguyen (Cambridge, Massachusetts); Irene Ghobrial (Boston, Massachusetts); Alexandre Detappe (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein are compounds of Formula (I) or (II). The compounds include an agent (e.g., pharmaceutical agent, cosmetic agent, or nutraceutical agent) through a linker that includes a boronic ester moiety in the backbone of the linker. The compounds may be monomers. Also provided are polymers prepared by polymerizing the monomers. The polymers may be useful for delivering the agent to a subject, tissue, biological sample, or a cell. Also provided are methods of preparing the polymers, compositions and kits comprising the polymers, and methods of use (e.g., use in delivering the agent, treating a disease, preventing a disease, diagnosing a disease) involving the polymers or compositions. The structure of the boronic ester moiety may be fine tuned so that the properties related to delivery to a subject, biological sample, tissue, or cell may be fine tuned. |
| FILED | Friday, March 20, 2020 |
| APPL NO | 16/825269 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/59 (20170801) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 85/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317149 | Lopez-Mejias et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vilmali Lopez-Mejias (San Juan, Puerto Rico); Lesly Y. Carmona-Sarabia (San Juan, Puerto Rico); Andrea M. Escalera Joy (San Juan, Puerto Rico); Darilys Mojica Vazquez (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vilmali Lopez-Mejias (San Juan, Puerto Rico); Lesly Y. Carmona-Sarabia (San Juan, Puerto Rico); Andrea M. Escalera Joy (San Juan, Puerto Rico); Darilys Mojica Vazquez (San Juan, Puerto Rico) |
| ABSTRACT | The invention provides extended bisphosphonate-based metal complexes using benzene1,4-bis(bisphosphonic acid) (BBPA), an analog of benzene 1,4-dicarboxylic acid (BDC). Hydrothermal synthesis of BBPA with the bioactive metals Ca2+, Zn2+, and Mg2+ leads to four crystals phases, namely, BBPA-Ca forms I and II, BBPA-Zn form I, and BBPA-Mg form I. Out of the three structures, BBPA-Ca form II presents large channels (8 Å×12 Å), potentiating the use of this framework to load drugs. Dissolution profiles were conducted to investigate the release of BBPA from BBPA-based metal complexes under physiological conditions (phosphate-buffered saline, PBS). These results show that <50% of BBPA was released from the BBPA-based metal complexes after 72 h. Binding assays employing hydroxyapatite (HA) were conducted to explore the affinity of BBPA to the bone microenvironment. About 99% of the BBPA could bind to HA in 10 days, revealing that BBPA is capable of binding to the bone. Cytotoxicity effects of BBPA was elucidated in a human breast cancer MDA-MB-231 and a normal osteoblast hFOB 1.19 cell lines. The half-maximal inhibitory concentration (IC50) for BBPA used to treat both cell lines were >200 μM at 24, 48, and 72 h of treatment. The BBPA in the range of concentration employed (0-200 μM) was no cytotoxic against these cell lines. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228629 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/386 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317168 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sophia Li (Santa Cruz, California); Phillip Berman (Santa Cruz, California) |
| ABSTRACT | The present disclosure reports that a calcium-dependent serine protease, complement component is (C1s) has been identified as a protease responsive for cleavage of exogenous polypeptides expressed in mammalian cell lines such as CHO cells. These CHO cell lines provide for increased yield of antigenically correct, uncleaved exogenous polypeptide as compared to unmodified CHO cells expressing the active C1s protease. C1s-deficient cell lines and methods for use of same for producing exogenous polypeptides, e.g., human immunodeficiency virus (HIV) envelope glycoprotein polypeptides, such as, gp120 or human Factor VIII are provided. |
| FILED | Wednesday, October 09, 2019 |
| APPL NO | 17/282288 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/003 (20130101) C12N 9/22 (20130101) C12N 9/93 (20130101) C12N 9/6424 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2740/16022 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 105/01003 (20130101) C12Y 603/01002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317169 | Barouch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan H. Barouch (Newton, Massachusetts); Joseph Patrick Nkolola (Watertown, Massachusetts) |
| ABSTRACT | The invention features stabilized human immunodeficiency virus (HIV) envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV Env trimers. In addition, the invention features methods of making and using the stabilized HIV Env trimers of the invention. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 17/304557 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 2039/55505 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/162 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2740/16111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317182 | Scholler et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathalie Scholler (Narberth, Pennsylvania); Katarzyna Urbanska (Philadelphia, Pennsylvania); Daniel J. Powell (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (UnivIR) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353414 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6851 (20170801) Peptides C07K 14/465 (20130101) C07K 14/7051 (20130101) Original (OR) Class C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 2319/00 (20130101) C07K 2319/03 (20130101) C07K 2319/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317186 | Kuchroo et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vijay K. Kuchroo (Boston, Massachusetts); Chao Wang (Boston, Massachusetts); Aviv Regev (Cambridge, Massachusetts); Karthik Shekhar (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are methods for suppressing an immune response in a subject, e.g., a subject with an autoimmune disease, by administering to the subject a therapeutically effective amount of recombinant CD5L, CD5L homodimers and/or CD5L:p40 heterodimers, or nucleic acids encoding any of these. Also described are methods for enhancing an immune response in a subject, e.g., a subject with cancer, infection, or an immune deficiency, by administering to the subject a therapeutically effective amount of an antibody or antigen-binding fragment thereof that binds specifically to CD5L, D5L homodimers and/or CD5L:p40 heterodimers, and inhibits their binding to the IL-23 receptor, or inhibits formation of the CD5L homodimer and/or CD5L:p40 heterodimer, or inhibitory nucleic acids that target CD5L and/or p40. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226506 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) A61K 38/208 (20130101) A61K 38/1709 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 35/00 (20180101) A61P 37/00 (20180101) Peptides C07K 14/5434 (20130101) C07K 14/70596 (20130101) Original (OR) Class C07K 16/244 (20130101) C07K 16/2896 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1136 (20130101) C12N 15/1138 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317234 | LUO et al. |
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| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juntao LUO (Jamesville, New York); Wei HE (Davis, California); Kit S. LAM (Davis, California); Paul HENDERSON (Dublin, California); Matthew A. COLEMAN (Oakland, California) |
| ABSTRACT | The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer, each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308921 |
| CURRENT CPC | Peptides C07K 14/775 (20130101) C07K 17/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317397 | EPSTEIN |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Slava EPSTEIN (Dedham, Massachusetts) |
| ABSTRACT | High capacity, low cost devices for use in growing monocultures of novel, previously unknown microbial species contain adhesive layers with wells covered by nanoporous membranes. The devices are placed in natural environments for cultivation of unknown microbial species. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228528 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/14 (20130101) C12M 23/24 (20130101) C12M 29/04 (20130101) Original (OR) Class C12M 37/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317403 | VALERIA CANTO-SOLER et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, A Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maria VALERIA CANTO-SOLER (Denver, Colorado); Miguel FLORES BELLVER (Centennial, Colorado); Kang LI (Aurora, Colorado); Silvia APARICIO DOMINGO (Centennial, Colorado) |
| ABSTRACT | Provided herein are methods for generating stem cell-derived retinal pigment epithelial monolayer cultures as well as methods of using the same. Also provided are populations of retinal pigment epithelial cells prepared according to these methods. In addition, three-dimensional tissue products derived from human induced pluripotent stem cells are also provided along with methods of making and using the same. |
| FILED | Thursday, May 09, 2019 |
| APPL NO | 17/053422 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class C12N 5/0621 (20130101) C12N 2502/085 (20130101) C12N 2513/00 (20130101) C12N 2527/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) G01N 2800/164 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317415 | WOODS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ossium Health, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erik J. WOODS (Carmel, Indiana); Brian H. JOHNSTONE (Fishers, Indiana) |
| ABSTRACT | Provided herein are methods and systems for recovering bone marrow. The methods comprising perfusing a bone with a perfusion media and recovering the liberated bone marrow cells. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/227217 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 5/0663 (20130101) C12N 5/0669 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317429 | CHOUDHARY et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit CHOUDHARY (Boston, Massachusetts); Debasish MANNA (Boston, Massachusetts); Basudeb MAJI (Cambridge, Massachusetts); Soumyashree Ashok GANGOPADHYAY (Boston, Massachusetts) |
| ABSTRACT | The disclosure includes non-naturally occurring or engineered DNA- or RNA-guided nuclease systems, comprising CRISPR enzymes associated with at least one destabilization domain (DD) and photocaged stabilization ligands with at least one photocage molecule, along with compositions, systems and complexes involving such systems, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses thereof. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/270196 |
| CURRENT CPC | Heterocyclic Compounds C07D 239/49 (20130101) C07D 405/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317451 | SCHAEFER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York); The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne SCHAEFER (New York, New York); Paul GREENGARD (New York, New York) |
| ABSTRACT | The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method comprises administering to the central nervous system of an individual in need of such treatment a therapeutically effective amount of an agent capable of increasing the expression and/or activity of miR-128. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/099209 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 67/0276 (20130101) A01K 2217/052 (20130101) A01K 2217/075 (20130101) A01K 2217/203 (20130101) A01K 2227/105 (20130101) A01K 2267/0356 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/185 (20130101) A61K 49/0008 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/315 (20130101) C12N 2310/341 (20130101) C12N 2310/346 (20130101) C12N 2310/3515 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317473 | Stitzel |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| INVENTOR(S) | Michael Stitzel (Bar Harbor, Maine) |
| ABSTRACT | Provided herein, in some aspects, are methods for preventing or treating diabetes in a subject, the method comprising assaying a genomic sample obtained from the subject for an intergenic variant located in a region between a C2 calcium-dependent domain containing 4A gene (C2CD4A) and a C2 calcium-dependent domain containing 4B gene (C2CD4B), and when the intergenic variant is present in the genomic sample, administering to the subject a therapy for diabetes. Also provided herein are rodent cells homozygous for a C2cd4a mutation and/or homozygous for a C2cd4h mutation, and methods for producing the rodent cells. |
| FILED | Thursday, January 31, 2019 |
| APPL NO | 16/966287 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2227/105 (20130101) A01K 2267/0362 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8509 (20130101) Original (OR) Class C12N 2015/8527 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317475 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Guangping Gao (Westborough, Massachusetts); Phillip D. Zamore (Northborough, Massachusetts); Shaoyong Li (Hopkinton, Massachusetts) |
| ABSTRACT | The disclosure in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193030 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/28 (20130101) A61K 38/51 (20130101) A61K 38/446 (20130101) A61K 38/1709 (20130101) A61K 38/4846 (20130101) A61K 48/0008 (20130101) Peptides C07K 16/10 (20130101) C07K 16/22 (20130101) C07K 16/32 (20130101) C07K 16/2875 (20130101) C07K 16/2887 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 15/117 (20130101) C12N 2310/17 (20130101) C12N 2310/141 (20130101) C12N 2320/30 (20130101) C12N 2330/51 (20130101) C12N 2710/10322 (20130101) C12N 2710/10332 (20130101) C12N 2750/14143 (20130101) C12N 2760/00042 (20130101) C12N 2830/008 (20130101) Enzymes C12Y 115/01001 (20130101) C12Y 304/21022 (20130101) C12Y 401/01028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317479 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Tyson Shepherd (Cambridge, Massachusetts); Rémi Veneziano (Cambridge, Massachusetts); Mark Bathe (Cambridge, Massachusetts); Ian Slaymaker (Cambridge, Massachusetts); Bernd Zetsche (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed are compositions and methods involving nucleic acid assemblies that enclose and/or protect cargo. Disclosed are compositions that include a nucleic acid assembly comprising one or more nucleic acid molecules and cargo comprising two or more cargo molecules. The nucleic acid assembly can have physiochemical properties that: (i) enhance targeting of the composition to one or more types of cells, tissues, organs, or microenvironments relative to other types of cells, tissues, organs, or microenvironments in vivo; (ii) enhance stability and/or half-life of the composition in vivo; and/or (iii) reduce immunogenicity of the composition. The nucleic acid assembly and/or cargo can have features that enhance intracellular trafficking of nucleic acid assembly and/or its cargo. The cargo can be enclosed and/or protected by the nucleic acid assembly. Some or all of the cargo molecules in the composition can be present in a defined stoichiometric ratio. |
| FILED | Friday, September 06, 2019 |
| APPL NO | 17/273999 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/513 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/88 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317506 | HE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Chuan HE (Chicago, Illinois); Qiancheng YOU (Chicago, Illinois) |
| ABSTRACT | Certain embodiments are directed to compositions and methods for capture of elements in physical proximity. In certain aspects the methods comprise (a) contacting a target with a functionalized scaffold or capture agent that comprises activatable cross-linking moieties to form a target/scaffold mixture; (b) exposing the target/scaffold mixture to an activator to activate the cross-linking moieties of the dendrimer and form a cross-linked target/scaffold complex; (c) isolating the target/scaffold complexes; and (d) identify portions of the target or targets that are cross linked with the scaffold. |
| FILED | Wednesday, May 08, 2019 |
| APPL NO | 17/250024 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317508 | SHARON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Axial Therapeutics, Inc. (Woburn, Massachusetts); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gil SHARON (Los Angeles, California); Sarkis MAZMANIAN (Glendale, California); Ryan BARRETT (Acton, Massachusetts); Anthony Stewart CAMPBELL (Framingham, Massachusetts) |
| ABSTRACT | Aspects of the invention described herein relate to bacteria and metabolites, which may be used in diagnostics, therapeutics and/or dietary supplements so as to identify the risk to an individual of developing ASD or ASD-like disorders, as well as, to inhibit, treat, and/or prevent the onset of ASD and/or and ASD-like disorders. |
| FILED | Monday, July 30, 2018 |
| APPL NO | 16/635752 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/195 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210317510 — METHODS AND SYSTEMS FOR DETERMINING SPATIAL PATTERNS OF BIOLOGICAL TARGETS IN A SAMPLE
| US 20210317510 | CHEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| ASSIGNEE(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| INVENTOR(S) | Mark S. CHEE (San Diego, California); David A. ROUTENBERG (San Diego, California) |
| ABSTRACT | The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358280 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317528 | EGGERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GENOMICS USA, INC. (ROUND ROCK, Texas) |
| ASSIGNEE(S) | GENOMICS USA, INC. (ROUND ROCK, Texas) |
| INVENTOR(S) | FREDERICK H. EGGERS (SAHUARITA, Arizona); GEORGINA LOPEZ PADILLA (BURNABY, Canada); PO LIN (TUSCON, Arizona); KEVIN O'BRIEN (SAHUARITA, Arizona); MICHAEL E. HOGAN (STONY BROOK, New York); KRISHNA JAYARAMAN (ROUND ROCK, Texas) |
| ABSTRACT | Complex blood group typing can be performed at the DNA level, using for example, air-dried cheek swabs or finger prick blood in a microarray test that completely bypasses the need for DNA extraction prior to analysis of the blood group type. |
| FILED | Tuesday, July 23, 2019 |
| APPL NO | 17/250447 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) C12Q 1/6881 (20130101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 50/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317529 | Green et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Michael R. Green (Boylston, Massachusetts); Sanchita Bhatnagar (Free Union, Virginia) |
| ABSTRACT | In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 16/897549 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2227/10 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317532 | Vogelstein et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); D. Williams Parsons (Bellaire, Texas); Xiaosong Zhang (San Francisco, California); Jimmy Cheng-Ho Lin (Baltimore, Maryland); Rebecca J. Leary (Cambridge, Massachusetts); Philipp Angenendt (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Victor Velculescu (Dayton, Maryland); Giovanni Parmigiani (Baltimore, Maryland); Rachel Karchin (Towson, Maryland); Sian Jones (Baltimore, Maryland); Hai Yan (Durham, Maryland); Darell Bigner (Mebane, North Carolina); Chien-Tsun Kuan (Cary, North Carolina); Gregory J. Riggins (White Hall, Maryland) |
| ABSTRACT | We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/091658 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317535 | Wahl et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Wahl (Ann Arbor, Michigan); Shuang Zhao (Ann Arbor, Michigan); Jann Sarkaria (Rochester, Minnesota) |
| ABSTRACT | Methods of treating a tumor in a subject are provided herein. In exemplary embodiments, the method comprises measuring the expression level of MGMT, GPRASP1, CHGA, MAPK8, ATP6V0A2, or FGF7, or any combination thereof, in a sample comprising a cell or cells from the tumor, and administering to the subject an alkylating chemotherapy, radiation therapy, or a combination comprising alkylating chemotherapy and radiation therapy, depending on the expression level(s). Related methods, kits, systems, computer-readable storage media, and methods implemented by a processor in a computer are further provided herein. |
| FILED | Thursday, August 29, 2019 |
| APPL NO | 17/271981 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/495 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318111 | Vakoc et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin J. Vakoc (Arlington, Massachusetts); Norman Lippok (Quincy, Massachusetts) |
| ABSTRACT | A method including: scanning a sample over a period of time using an electro-magnetic radiation source, the period of time including a first time period and a second time period, a sample portion of the electro-magnetic radiation source being directed to the sample in a sample arm of an optical interferometric system, and a reference portion of the electro-magnetic radiation source being directed to a reference arm of the optical interferometric system; applying, using a phase modulator, a phase shift comprising a first phase shift and a second phase shift to at least one of the reference portion or the sample portion of the electro-magnetic radiation source, the first phase shift being applied during the first time period and the second phase shift being applied during the second time period, the second phase shift having a difference of 90 degrees from the first phase shift; acquiring in-phase data based on a first interference between first backscattered electro-magnetic radiation during the first time period and the at least one of the reference portion or the sample portion subjected to the first phase shift; acquiring quadrature data based on a second interference between second backscattered electro-magnetic radiation during the second time period and the at least one of the reference portion or the sample portion subjected to the second phase shift; and determining a complex interference signal based on the in-phase data and the quadrature data. |
| FILED | Tuesday, July 30, 2019 |
| APPL NO | 17/264165 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/0201 (20130101) Original (OR) Class G01B 9/02008 (20130101) G01B 9/02091 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318288 | Drndic et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marija Drndic (Philadelphia, Pennsylvania); Yung-Chien Chou (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are nanopore devices that include a hafnium oxide coating on the pores of the devices. Such devices exhibit improved stability, especially when in a salt solution environment. Also provided are related methods. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/218365 |
| CURRENT CPC | Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00087 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318296 | Johnson-Buck et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Johnson-Buck (Ann Arbor, Michigan); Muneesh Tewari (Ann Arbor, Michigan); Nils G. Walter (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein is technology relating to detecting analytes and particularly, but not exclusively, to methods, compositions and systems for detecting, characterizing, identifying, and/or quantifying analytes. |
| FILED | Tuesday, July 23, 2019 |
| APPL NO | 17/259601 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) G01N 33/542 (20130101) Original (OR) Class G01N 33/557 (20130101) G01N 33/5302 (20130101) G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318307 | Savidge et al. |
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| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tor Savidge (League City, Texas); Qinglong Wu (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure include methods and compositions related to accurate diagnosis and treatment of medical conditions having diarrhea as a symptom. In specific cases, the disclosure concerns accurate assessment of a diarrheal cause related to the presence or risk that may or may not be a pathogenic infection, such as a Clostridioides difficule infection (CDI). Particular embodiments encompass one or more specific features that provide information for accurate diagnosis and treatment of CDI versus another cause for diarrhea. |
| FILED | Thursday, September 19, 2019 |
| APPL NO | 17/274529 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) Original (OR) Class G01N 2333/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318312 | Shenk et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Shenk (Princeton, New Jersey); Todd M. Greco (Langhorne, Pennsylvania); Ileana M. Cristea (Princeton, New Jersey); Rommel A. Mathias (Plainsboro, New Jersey); Adam Oberstein (Princeton, New Jersey) |
| ABSTRACT | The present application demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors. |
| FILED | Wednesday, August 12, 2020 |
| APPL NO | 16/991429 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class G01N 2333/90212 (20130101) G01N 2333/91057 (20130101) G01N 2500/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318329 | COHEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | Colorado State University Research Foundation (Fort Collins, Colorado); Colorado State University Research Foundation (Fort Collins, Colorado) |
| INVENTOR(S) | Robert E. COHEN (Fort Collins, Colorado); Yun-Seok CHOI (Fort Collins, Colorado) |
| ABSTRACT | The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237464 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) C07K 14/435 (20130101) C07K 2319/00 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) Enzymes C12Y 304/19012 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) Original (OR) Class G01N 33/6872 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318335 | Khandelwal et al. |
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| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Sanjay Khandelwal (Durham, North Carolina); Gowthami Arepally (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides methods of determining the presence of the risk of developing complement activation by protein/heparin binding complexes in a subject, methods of determining the presence of complement activation by protein/heparin binding complexes in a subject, and methods of treating diseases including heparin-induced thrombocytopenia (HIT) in a subject by administering a compound capable of blocking the classical pathway of complement activation. |
| FILED | Wednesday, August 28, 2019 |
| APPL NO | 17/271841 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Peptides C07K 16/18 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 2800/24 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319122 | Sadeh et al. |
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| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Norman Sadeh (Pittsburgh, Pennsylvania); Bin Liu (Pittsburgh, Pennsylvania); Anupam Das (Pittsburgh, Pennsylvania); Martin Degeling (Pittsburgh, Pennsylvania); Florian Schaub (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system and method configures permission settings for applications (“apps”) running on a computing device of a user. A data center generates at least one model of collective privacy preferences. The computing device is in communication with the data center via a communications network. The computing device comprises a processor that execute at least a first app that requests access to at least one permission of the computing device and a personal privacy assistant app. The personal privacy assistant app receives the at least one model from the one or more servers of the data center; collects information about the user; identifies at least one recommended permission setting for the first app based on the at least one model and such that the recommended permission setting is user-specific; and configures the computing device to implement the received at least one user-specific recommended permission setting. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165775 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/604 (20130101) Original (OR) Class G06F 21/629 (20130101) G06F 21/6245 (20130101) Computer Systems Based on Specific Computational Models G06N 7/00 (20130101) G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/101 (20130101) H04L 63/102 (20130101) H04L 67/12 (20130101) H04L 67/22 (20130101) H04L 67/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319600 | Tao et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shengzhen Tao (Rochester, Minnesota); Shuai Leng (Rochester, Minnesota); Cynthia H. McCollough (Byron, Minnesota) |
| ABSTRACT | A system and method is provided for high fidelity multi-energy CT processing. This system and method exploits prior knowledge, where prior knowledge may include redundant information existing in the CT images, such as spatial redundancy between a thick slice and a thin slice encompassed by or close to the thick slice, or the spatiospectral redundancy between the image output of multi-energy CT processing and the source multi-energy CT images. The system and method retains structural details, spatial resolution, spectral fidelity, and noise texture while achieving noise reduction. The method reduces image noise and increases the contrast-to-noise ratio in processed images, while simultaneously maintaining image details and natural appearance of the image to enhance detectability and facilitate reader acceptance. |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/256404 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/5211 (20130101) A61B 6/5258 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/50 (20130101) G06T 11/005 (20130101) G06T 11/008 (20130101) Original (OR) Class G06T 2207/10081 (20130101) G06T 2211/408 (20130101) G06T 2211/424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319786 | Kain et al. |
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| FUNDED BY |
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| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Kain (Portland, Oregon); Amie Roten (Portland, Oregon) |
| ABSTRACT | Disclosed are embodiments for mapping, with a first trained universal function approximator, the speech representation to predicted phonological feature and phoneme class probabilities; determining expected phonological feature values based on an automatic phonetic segmentation using the expected phoneme sequence and the predicted phoneme class probabilities; and classifying, with a second trained universal function approximator different from the first trained universal function approximator, a combination of the predicted phonological feature probabilities and the expected phonological feature values to thereby detect a mispronunciation present in the sampled speech waveform and facilitate phonological feature feedback associated with the mispronunciation. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225571 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/02 (20130101) G10L 15/04 (20130101) G10L 15/16 (20130101) G10L 15/22 (20130101) G10L 15/063 (20130101) G10L 15/187 (20130101) Original (OR) Class G10L 15/197 (20130101) G10L 2015/025 (20130101) G10L 2015/225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319848 | MINOT et al. |
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| FUNDED BY |
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| APPLICANT(S) | FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington); UNIVERSITY OF WASHINGTON (Seattle, Washington); THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel S. MINOT (Seattle, Washington); Amy Donaldson WILLIS (Seattle, Washington); Jonathan Louis GOLOB (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are systems and methods for identifying associations, or lack thereof, between microbial strains (e.g., bacterial strains) and phenotypic features (e.g., demographic characteristics, physical statistics, and/or medical history) of a subject. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225991 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/483 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) Original (OR) Class G16B 30/10 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320969 | Desai |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shyamal D. Desai (Metairie, Louisiana) |
| ABSTRACT | This invention is directed to compositions and methods for detecting proteinopathies. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/215980 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 67/1002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210315492 | Najdahmadi et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avid Najdahmadi (Irvine, California); John Weidling (Irvine, California); Elliot L. Botvinick (Irvine, California) |
| ABSTRACT | A composite material for detecting and measuring levels of analytes and target molecules in biological fluid and tissue is disclosed herein. This composite material is constructed from a porous mesh sheet that is coated with a signal emitting material and is impregnated with target detecting molecules mixed inside one or multiple polymer mixtures. The geometry and configuration of different constituents can provide high efficiency of signals, the ability to measure multiple signals, small dimensions, fast response to changes, long storage lifetimes, controlled diffusional and mechanical properties, as well as easy industrial manufacturability. The composite material can be used in many sensing applications including optical or electrochemical continuous biosensing such as continuous glucose and lactate monitors. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/177570 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1459 (20130101) Original (OR) Class A61B 5/1473 (20130101) A61B 5/14503 (20130101) A61B 5/14532 (20130101) A61B 5/14546 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/50 (20130101) C08F 14/26 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/20 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315517 | Quatieri et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Francis Quatieri (Newtonville, Massachusetts); Jeffrey Palmer (Westford, Massachusetts); Tanya Talkar (Cambridge, Massachusetts) |
| ABSTRACT | A multi-modal approach is used to detect and track inflammation, and identify location of inflammation, which is revealed in changes in tissue and physiological properties that underlie sub-systems, including respiratory, sinus, laryngeal, articulatory, facial and gastrointestinal components. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226442 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/053 (20130101) A61B 5/0075 (20130101) A61B 5/4803 (20130101) Original (OR) Class A61B 5/7264 (20130101) A61B 7/003 (20130101) A61B 7/008 (20130101) A61B 2562/0204 (20130101) A61B 2562/0219 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315814 | Lu et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Quan Lu (Cambridge, Massachusetts); Joseph F. Nabhan (Cambridge, Massachusetts); Stanley N. Cohen (Palo Alto, California) |
| ABSTRACT | The invention provide isolated arrestin domain-containing protein 1 (ARRDC1)-mediated microvesicles (ARMMs). Methods for generating and for isolating ARMMs are also provided herein. ARMMs can be used to deliver agents, for example, nucleic acids (e.g., siRNAs, microRNAs, lincRNAs), proteins (e.g., transcription factors, chromatin modulators, kinases, phosphorylases, or recombinases), or small molecules to target cells in vitro and in vivo, and methods for such ARMM-mediated delivery are provided herein. Diagnostic and therapeutic methods using ARMMs are also described herein. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168988 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/107 (20130101) Original (OR) Class A61K 47/42 (20130101) Peptides C07K 14/47 (20130101) C07K 2319/00 (20130101) C07K 2319/70 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/47 (20130101) G01N 2333/726 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315901 | DIACOVO |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Thomas DIACOVO (Larchmont, New York) |
| ABSTRACT | The present invention provides, inter alia, methods for treating, preventing, or ameliorating the effects of a lymphoid malignancy, such as those associated with a mutated phosphatase and tensin homolog (PTEN) gene, or T-cell acute lymphoblastic leukemia (T-ALL). These methods include administering to a subject an effective amount of a phosphoinositide 3-kinase-delta (PI3Kδ) inhibitor and a phosphoinositide 3-kinase-gamma (PI3Kγ) inhibitor. The present invention also provides pharmaceutical compositions for treating the effects of a lymphoid malignancy. This invention further provides a method for identifying a subject who may benefit from co-treatment with a PI3Kδ inhibitor and a PI3Kγ inhibitor. This method includes determining from a sample of the subject whether the subject has a mutated PTEN gene. Additionally, this invention provides methods for identifying a compound that has both PI3Kδ and PI3Kγ inhibitory activity. |
| FILED | Tuesday, November 17, 2020 |
| APPL NO | 16/950413 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) Original (OR) Class A61K 31/573 (20130101) A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1205 (20130101) C12N 15/1137 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Enzymes C12Y 207/01137 (20130101) C12Y 207/01153 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/5041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315968 | MA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRIM-edicine, Inc. (Columbus, Ohio) |
| ASSIGNEE(S) | OHIO STATE INNOVATION FOUNDATION (COLUMBUS, Ohio) |
| INVENTOR(S) | JIANJIE MA (POWELL, Ohio); JACOB S. YOUNT (COLUMBUS, Ohio); MATTHEW A. SERMERSHEIM (NASHVILLE, Tennessee); ADAM D. KENNEY (COLUMBUS, Ohio); Xinyu ZHOU (HILLIARD, Ohio); BRYAN A. WHITSON (WESTERVILLE, Ohio); NAHUSH A. MOKADAM (UPPER ARLINGTON, Ohio); TAO TAN (COLUMBUS, Ohio); CHUANXI CAI (POWELL, Ohio) |
| ABSTRACT | Compositions for and methods of preventing, reversing or treating viral infection-induced organ failure provided. The compositions are also suitable for treating and/or preventing COVID-19 and influenza. The compositions and methods employ MG53, which can be in the form of recombinant human MG53. The MG53 may also be administered as a composition that expresses and releases MG53 after in vivo administration of said composition to a subject. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/184781 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316175 | Bjorkquist et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TSI INCORPORATED (Berkeley, California); Aerosol Dynamics Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel C. Bjorkquist (Shoreview, Minnesota); Arantzazu Eiguren Fernandez (El Cerrito, California); Kenneth Farmer (Lake Elmo, Minnesota); Melissa Grose (Shoreview, Minnesota); Susanne Vera Hering (Berkeley, California); Gregory Stephen Lewis (Berkeley, California); Steven Russel Spielman (Oakland, California); David Workman (Shoreview, Minnesota) |
| ABSTRACT | A system includes a first and second condensation particle counter, each counter having an inlet port, a growth column, and an optical element for counting particles detected at the respective inlet ports. The counters are configured to include a wick in which the wick is wetted by water. A differential pressure sensor is coupled to the first inlet port and coupled to the second inlet port. The sensor is configured to provide a pressure signal. A processor is coupled to memory and configured to receive the first signal, the second signal, and the pressure signal and generate an output corresponding to a ratio of the first signal and the second signal and correlate the ratio with the pressure signal. A housing is configured to receive the first counter, the second counter, the differential pressure sensor, the processor, and the memory. |
| FILED | Thursday, October 31, 2019 |
| APPL NO | 17/290216 |
| CURRENT CPC | Devices, Apparatus or Methods for Life-saving A62B 27/00 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2273 (20130101) G01N 15/065 (20130101) G01N 2015/0046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316318 | Damit et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian E. Damit (Silver Spring, Maryland); Plamen A. Demirev (Ellicott City, Maryland); Elizabeth C. Corson (Columbia, Maryland); Felix C. Sage (Ijamsville, Maryland); Benjamin B. Alvarez (Hanover, Maryland); Charles A. Fancher (Baltimore, Maryland); Kelly A. Van Houten (West Friendship, Maryland); Christopher J. Rosenker (North Bethesda, Maryland) |
| ABSTRACT | A cyclone includes a hollow cylindrical upper portion and a hollow conical lower portion having an inclined wall and a base wall. The base wall and the inclined wall are continuous contact with each other, and the inclined wall of the hollow conical lower portion is in continuous contact with an outer wall of the hollow cylindrical upper portion. A total cyclone height is from about 10 to about 30 millimeters, and a ratio of the total cyclone height to an inner diameter of the hollow cylindrical upper portion is from about 0.7 to about 1.3. An angle between an inner surface of the base wall and an inner surface of the inclined wall is from about 110 to about 130 degrees. |
| FILED | Tuesday, September 01, 2020 |
| APPL NO | 17/008859 |
| CURRENT CPC | Apparatus Using Free Vortex Flow, e.g Cyclones B04C 5/04 (20130101) B04C 5/20 (20130101) B04C 5/081 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2211 (20130101) G01N 1/4077 (20130101) G01N 33/0011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316392 | Raghavan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashwin Raghavan (West Hartford, Connecticut); Enrique E. Montero (Marlborough, Connecticut); Max A. Kaplan (West Hartford, Connecticut); Eli N. Ross (Vernon, Connecticut); Mario P. Bochiechio (Vernon, Connecticut) |
| ABSTRACT | A joining method includes performing a first heat treatment step on a first superalloy workpiece and a second superalloy workpiece wherein at least one of the first and second superalloy workpieces include a gamma matrix phase and a gamma-prime precipitate phase. The first and second superalloy workpieces are joined using a solid state joining process, subjected to a post-weld stress relief operation and a final aging heat treatment. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/173932 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 11/04 (20130101) B23K 20/12 (20130101) B23K 20/233 (20130101) Original (OR) Class B23K 35/3033 (20130101) B23K 2101/001 (20180801) Alloys C22C 19/03 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316844 | Fasel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (TUCSON, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hermann F. Fasel (Tucson, Arizona); Christoph Hader (Tucson, Arizona) |
| ABSTRACT | A system and method for controlling boundary layer transition for a high-speed vehicle are disclosed. The method includes determining a location of onset of boundary-layer transition that naturally develops during high-speed flight of the high-speed vehicle, and providing a pair of flow control strips at a surface/wall/skin of the high-speed vehicle such that the boundary-layer transition is delayed or prevented during high-speed flight of the high-speed vehicle. The delayed or prevented locations of the transition result in a change in the high-speed boundary layer during the high-speed flight of the high-speed vehicle. The change in the high-speed boundary layer transition affects skin friction drag, aero-thermodynamic heating, and pressure fluctuations in the boundary layer of the high-speed vehicle. |
| FILED | Thursday, December 24, 2020 |
| APPL NO | 17/134047 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 21/025 (20130101) Original (OR) Class B64C 23/005 (20130101) B64C 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316987 | Fischman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jason Fischman (Stamford, Connecticut); Peter Godart (Cambridge, Massachusetts); Douglas P. Hart (Charlestown, Massachusetts); Andrew Whitehead (Somerville, Massachusetts); Jean Sack (Eureka, California); Eric Morgan (Bolton, Massachusetts) |
| ABSTRACT | A stable aluminum slurry fuel and related systems and methods of use are provided herein. Certain embodiments of the disclosure are related to an aluminum slurry fuel comprising a plurality of aluminum particles dispersed in a carrier fluid. In some embodiments, the aluminum particles comprise an activating composition comprising gallium and/or indium. Additionally, methods of making and using the aluminum slurry fuel are presented herein. For instance, the resultant aluminum slurry fuel may react exothermically with water over a wide range of temperatures to produce hydrogen. The resulting slurry fuel may be used as an energy source for various applications and/or for generating hydrogen for other applications. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/138107 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 3/08 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0606 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317002 | Long et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jeffrey W. Long (Alexandria, Virginia); Christopher N. Chervin (Washington, District of Columbia); Robert B. Balow (Mount Ranier, Maryland); Jeffrey C. Owrutsky (Silver Spring, Maryland); Debra R. Rolison (Arlington, Virginia); Kenan O. Fears (Alexandria, Virginia) |
| ABSTRACT | Disclosed is a method of decontamination by exposing a zirconium oxy(hydroxide) aerogel to a liquid, vapor, or gaseous sample suspected of containing a phosphonate compound. The aerogel may be doped with Fe3+ ions, Ce3+ ions, or SO42− ions. The aerogel may be made by: providing a solution of ZrCl4; FeCl3, CeCl3, or Zr(SO4)2; and a solvent; adding a cyclic ether to the solution to form a gel; infiltrating the gel with liquid carbon dioxide; applying a temperature and pressure to form supercritical fluid carbon dioxide; and removing the carbon dioxide for form an aerogel. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 16/953564 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/02 (20130101) Original (OR) Class C01G 25/003 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317036 | Hsieh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alex J. Hsieh (Winchester, Massachusetts); Tanya L. Chantawansri (Abingdon, Maryland) |
| ABSTRACT | Provided are materials that include one or more cycloaliphatic polyamides integrated into or coated onto one or more structural fibers such as polyethylene fibers, aramid-fibers, glass fibers or carbon fibers. The resulting materials may be incorporated into composite articles suitable for use as protective equipment or structural layers. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/356618 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/08 (20130101) B32B 27/12 (20130101) B32B 27/34 (20130101) B32B 2260/021 (20130101) B32B 2260/046 (20130101) B32B 2262/14 (20130101) B32B 2262/101 (20130101) B32B 2262/106 (20130101) B32B 2262/0253 (20130101) B32B 2262/0269 (20130101) B32B 2307/702 (20130101) B32B 2307/732 (20130101) B32B 2571/02 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/50 (20130101) C03C 25/328 (20130101) Original (OR) Class C03C 25/1095 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/042 (20130101) C08J 5/043 (20130101) C08J 2375/04 (20130101) C08J 2377/06 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 15/59 (20130101) D06M 15/564 (20130101) D06M 17/00 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/0485 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317047 | Vander Wal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randall L. Vander Wal (University Park, Pennsylvania); Madhu Singh (University Park, Pennsylvania) |
| ABSTRACT | A method of fabricating a carbon-carbon composite includes mixing a carbon-based matrix precursor with a carbon nanomaterial additive forming a polymeric matrix impregnated with the carbon nanomaterial additive, heating the impregnated polymeric matrix under an inert atmosphere, with temperatures ranging between 350-1100° C. for carbonization followed by graphitization at a temperature greater than 1800° C. The matrix precursor may be a graphitizing or non-graphitizing material. The additive may present basal or edge site carbon atoms or a combination of both. As a result, a carbon-carbon composite composed of the matrix and additive is formed by templating or bond formation, wherein at least 1-D nano-scale or micro-scale structural changes begins at the interface between the matrix and additive and propagates outward from the interface into the matrix, thus adjusting or altering the nano- or micro-structures in the matrix that would not naturally occur in the absence of the additive. |
| FILED | Wednesday, May 08, 2019 |
| APPL NO | 17/053385 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/83 (20130101) Original (OR) Class C04B 35/63476 (20130101) C04B 2235/425 (20130101) C04B 2235/656 (20130101) C04B 2235/5288 (20130101) C04B 2235/5292 (20130101) C04B 2235/5436 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317084 | Koide et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kazunori Koide (Pittsburgh, Pennsylvania); Kiflai Bein (Mars, Pennsylvania); George D. Leikauf (Gibsonia, Pennsylvania); Robert Kruger Bressin (West Homestead, Pennsylvania); James Proviano Burrows (West Homestead, Pennsylvania); Adriana Gambino (Pittsburgh, Pennsylvania); Dianne Pham (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are compounds useful in treating exposure to an organophosphorus compound, such as a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, such as sarin. Compositions, e.g. pharmaceutical compositions or dosage forms, comprising the compounds also are provided herein. Methods of treating a patient exposed to a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, e.g., an organophosphorus compound, such as sarin, also are provided. |
| FILED | Thursday, May 30, 2019 |
| APPL NO | 17/058429 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 213/53 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317090 | PHANSTIEL, IV et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida); Terrey Pines Institute for Molecular Studies (Port St. Lucie, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Otto PHANSTIEL, IV (Oviedo, Florida); Chelsea MASSARO (Apopka, Florida); Jenna THOMAS (Winter Park, Florida); Adel NEFZI (Port St. Lucie, Florida) |
| ABSTRACT | Novel compounds are described which decrease the intracellular levels of leucine and methionine. Treatment with these amino acid depletion agents affects many metabolic and life processes which rely upon methionine, leucine and their derivatives. Methionine depletion not only inhibits protein synthesis, but also polyamine biosynthesis and significantly reduces intracellular pools of the native polyamines, spermidine and spermine. Since methionine restriction has been shown to mimic caloric restriction in life extension studies across multiple species, these compounds are also expected to extend lifespan by limiting methionine supply. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 17/272436 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 241/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317120 | HADDACH |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Pimera, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mustapha HADDACH (San Diego, California) |
| ABSTRACT | Generally, the present invention provides novel quinolone and 5H-1,5,7,11b-tetraaza-benzo[c]fluoren-6-one compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204459 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) C07D 471/14 (20130101) Original (OR) Class C07D 471/22 (20130101) C07D 487/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317151 | KING et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arthur Paden KING (Ithaca, New York); Sierra C. MARKER (Ithaca, New York); Robert SWANDA (Windsor, New York); Shu-Bing QIAN (Ithaca, New York); Justin J. WILSON (Ithaca, New York) |
| ABSTRACT | A composition comprising the following structure: (1) wherein Re represents a rhenium ion having a +1 charge; (I) represents an uncharged bidentate ligand containing at least one ring containing a ring nitrogen atom bound to the rhenium (Re), and the bidentate ligand containing another nitrogen atom, either in a ring or not in a ring, bound to the rhenium (Re); and L1, L2, L3, and L4 are neutral ligands with at least one neutral ligand being an isonitrile ligand of the formula —CN—R, wherein R is an aliphatic or aromatic hydrocarbon group containing 1-20 carbon atoms; and X− represents a non-coordinating monovalent anion; wherein the bidentate ligand and R are optionally substituted by one or more groups selected from (i)-(xi) as further discussed above. Methods for treating a condition that benefits from ER stress induction, such as cancer, by administering the above rhenium complex are also disclosed. |
| FILED | Friday, August 16, 2019 |
| APPL NO | 17/267687 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 13/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317157 | Kuchta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (DENVER, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert D. Kuchta (Boulder, Colorado); Ayman Alawneh (Boulder, Colorado) |
| ABSTRACT | The present disclosure includes nucleosides and/or nucleotides comprising an optionally substituted alloxazine (also known as benzo[g]pteridine-2,4(1H,3H)-dione, or isoalloxazine) at the anomeric position. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224728 |
| CURRENT CPC | Heterocyclic Compounds C07D 471/04 (20130101) C07D 487/04 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/23 (20130101) Original (OR) Class C07H 21/02 (20130101) C07H 21/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317269 | Zoombelt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | Zymergen Inc. (Emeryville, California) |
| INVENTOR(S) | Arjan Zoombelt (Emeryville, California); Steven M. Edgar (Albany, California); Alejandra Alvarez Albarran (Emeryville, California) |
| ABSTRACT | A polymer film comprising at least two properties selected from (i) a thickness of not greater than 100 μm; (ii) a tensile modulus according to ASTM D882 of at least 5 GPa; (iii) a first optical transparency according to ASTM D1746-15 at 380 nm of less than 50%; (iii) a Yellowing Index according to ASTM E313-15e1 of not greater than 2.5; (iv) a haze as determined according to ASTM D1003-13 of not greater than 1.5%; (v) a pencil hardness of greater than 1H; (vi) a coefficient of moisture expansion (‘CME’) as determined according to ASTM D5229/D5229M-14 of not greater than 50 ppm; (vii) an elongation at break as determined according to ASTM D5034-09 (2017) of at least 10%; or (viii) a folding endurance as determined according to ASTM D2176-16 at a radius of 1 mm of at least 10,000 folds. |
| FILED | Tuesday, August 06, 2019 |
| APPL NO | 17/250589 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/1067 (20130101) C08G 73/1078 (20130101) Original (OR) Class Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2379/08 (20130101) C08J 2479/08 (20130101) Compositions of Macromolecular Compounds C08L 79/08 (20130101) C08L 2205/03 (20130101) C08L 2205/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317370 | MEENAKSHISUNDARAM |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | RAVI SHANKAR MEENAKSHISUNDARAM (ASPINWALL, Pennsylvania) |
| ABSTRACT | An optically transparent actuator apparatus is provided that includes an optically transparent bi-stable member including an optically transparent liquid crystalline polymer layer. The bi-stable member is structured to move from a first state to a second state in response to a first stimulus and from the second state to the first state in response to a second stimulus. Also, a display apparatus includes a plate member and an actuator assembly coupled to the plate member. The actuator assembly includes a number of optically transparent liquid crystalline polymer layers, wherein each of the optically transparent liquid crystalline polymer layers is structured to move from a first state to a second state in response to a first stimulus. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308186 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/38 (20130101) Original (OR) Class C09K 19/0208 (20130101) C09K 2219/03 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/065 (20130101) Electric Digital Data Processing G06F 3/016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317397 | EPSTEIN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Slava EPSTEIN (Dedham, Massachusetts) |
| ABSTRACT | High capacity, low cost devices for use in growing monocultures of novel, previously unknown microbial species contain adhesive layers with wells covered by nanoporous membranes. The devices are placed in natural environments for cultivation of unknown microbial species. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228528 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/14 (20130101) C12M 23/24 (20130101) C12M 29/04 (20130101) Original (OR) Class C12M 37/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317429 | CHOUDHARY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit CHOUDHARY (Boston, Massachusetts); Debasish MANNA (Boston, Massachusetts); Basudeb MAJI (Cambridge, Massachusetts); Soumyashree Ashok GANGOPADHYAY (Boston, Massachusetts) |
| ABSTRACT | The disclosure includes non-naturally occurring or engineered DNA- or RNA-guided nuclease systems, comprising CRISPR enzymes associated with at least one destabilization domain (DD) and photocaged stabilization ligands with at least one photocage molecule, along with compositions, systems and complexes involving such systems, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses thereof. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/270196 |
| CURRENT CPC | Heterocyclic Compounds C07D 239/49 (20130101) C07D 405/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317451 | SCHAEFER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York); The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne SCHAEFER (New York, New York); Paul GREENGARD (New York, New York) |
| ABSTRACT | The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method comprises administering to the central nervous system of an individual in need of such treatment a therapeutically effective amount of an agent capable of increasing the expression and/or activity of miR-128. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/099209 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 67/0276 (20130101) A01K 2217/052 (20130101) A01K 2217/075 (20130101) A01K 2217/203 (20130101) A01K 2227/105 (20130101) A01K 2267/0356 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/185 (20130101) A61K 49/0008 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/315 (20130101) C12N 2310/341 (20130101) C12N 2310/346 (20130101) C12N 2310/3515 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317473 | Stitzel |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| INVENTOR(S) | Michael Stitzel (Bar Harbor, Maine) |
| ABSTRACT | Provided herein, in some aspects, are methods for preventing or treating diabetes in a subject, the method comprising assaying a genomic sample obtained from the subject for an intergenic variant located in a region between a C2 calcium-dependent domain containing 4A gene (C2CD4A) and a C2 calcium-dependent domain containing 4B gene (C2CD4B), and when the intergenic variant is present in the genomic sample, administering to the subject a therapy for diabetes. Also provided herein are rodent cells homozygous for a C2cd4a mutation and/or homozygous for a C2cd4h mutation, and methods for producing the rodent cells. |
| FILED | Thursday, January 31, 2019 |
| APPL NO | 16/966287 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2227/105 (20130101) A01K 2267/0362 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8509 (20130101) Original (OR) Class C12N 2015/8527 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317479 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Tyson Shepherd (Cambridge, Massachusetts); Rémi Veneziano (Cambridge, Massachusetts); Mark Bathe (Cambridge, Massachusetts); Ian Slaymaker (Cambridge, Massachusetts); Bernd Zetsche (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed are compositions and methods involving nucleic acid assemblies that enclose and/or protect cargo. Disclosed are compositions that include a nucleic acid assembly comprising one or more nucleic acid molecules and cargo comprising two or more cargo molecules. The nucleic acid assembly can have physiochemical properties that: (i) enhance targeting of the composition to one or more types of cells, tissues, organs, or microenvironments relative to other types of cells, tissues, organs, or microenvironments in vivo; (ii) enhance stability and/or half-life of the composition in vivo; and/or (iii) reduce immunogenicity of the composition. The nucleic acid assembly and/or cargo can have features that enhance intracellular trafficking of nucleic acid assembly and/or its cargo. The cargo can be enclosed and/or protected by the nucleic acid assembly. Some or all of the cargo molecules in the composition can be present in a defined stoichiometric ratio. |
| FILED | Friday, September 06, 2019 |
| APPL NO | 17/273999 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/513 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/88 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317549 | Goswami et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Ramasis Goswami (Alexandria, Virginia); Syed B. Qadri (Fairfax Station, Virginia) |
| ABSTRACT | An aluminum magnesium alloy with reduced Samson phase at grain boundaries made from the method of providing aluminum in a container, adding boron to the container, providing an inert atmosphere, arc-melting the aluminum and the boron, and mixing the aluminum and the boron in the container to form an alloy mixture. A method of suppressing the Samson phase, Al3Mg2, at grain boundaries in Aluminum, comprising providing aluminum in a container, adding boron to the container, providing an inert atmosphere, arc-melting the aluminum and the boron, and mixing the aluminum and the boron in the container to form an alloy mixture. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307390 |
| CURRENT CPC | Alloys C22C 1/03 (20130101) Original (OR) Class C22C 1/026 (20130101) C22C 1/1094 (20130101) C22C 21/06 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317598 | Iyer et al. |
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| FUNDED BY |
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| APPLICANT(S) | North Carolina A and T State University (Greensboro, North Carolina) |
| ASSIGNEE(S) | North Carolina A and T State University (Greensboro, North Carolina) |
| INVENTOR(S) | Shanthi Iyer (Greensboro, North Carolina); Jia Li (Greensboro, North Carolina); Prithviraj Deshmukh (Hillsboro, Oregon); Manish Sharma (Hillsboro, Oregon) |
| ABSTRACT | Compositions comprising Group V/III nanowires, and methods of making such nanowires are described. Some compositions comprise one or more core-shell nanowires comprising a core and a first shell surrounding or substantially surrounding the core. The core is formed from GaAs(1-y)Sby, where y=about 0.03-0.07 and the first shell is formed from GaAs(1-x)SbxN, where x=0.27-0.34. The nanowires have an average emission maximum of 1.4-1.7 μm. Some nanowires further comprise a second shell surrounding or substantially surrounding the first shell. The second shell is formed from a Group V/III material such as Ga1-mAlmAs, where m=0-0.2. Some nanowires have the structure GaAs(0.93-0.97)Sb(0.03-0.07)/GaAs(0.66-0.73)Sb(0.27-0.34)N/Ga(0.8-1)Al(0-0.2)As. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229066 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/02 (20130101) C30B 29/40 (20130101) C30B 29/403 (20130101) Original (OR) Class C30B 29/605 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317868 | Haynes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert A. Haynes (Yorktown, Virginia); Todd C. Henry (Aberdeen, Maryland); Michael D. Coatney (Bel Air, Maryland) |
| ABSTRACT | A device includes a frame including a first end and a second end; a mechanism including a first side that faces the first end of the frame, and a second side that faces the second end of the frame; a first buckling member attached to the first side of the mechanism and the first end of the frame; a second buckling member attached to the second side of the mechanism and the second end of the frame; and at least one actuator that engages the mechanism, the first buckling member, and the second buckling member in a selective sequence causing the mechanism to articulate between the first end and the second end of the frame. Engagement of the first buckling member and the second buckling member by the at least one actuator causes the first buckling member and the second buckling member to buckle and unbuckle in the selective sequence. |
| FILED | Wednesday, April 08, 2020 |
| APPL NO | 16/842962 |
| CURRENT CPC | Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 1/16 (20130101) Original (OR) Class F16C 1/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318097 | Cabahug et al. |
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| FUNDED BY |
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| APPLICANT(S) | T-Worx Holdings, LLC (Sterling, Virginia) |
| ASSIGNEE(S) | T-Worx Holdings, LLC (Sterling, Virginia) |
| INVENTOR(S) | Eric Cabahug (Fairfax, Virginia); James Dodd (Linden, Virginia); John Schroeder (Leesburg, Virginia); Hector Tapia (Ashburn, Virginia); Ben Feldman (Reston, Virginia) |
| ABSTRACT | The present invention is related to weapons systems. In particular, the present invention is directed to accessory attachment systems for rifles and small arms weapons that enable attached accessory devices to draw power from a central power source and communicate with the user and/or other devices. The present invention embodies firearm systems comprising at least one mounting rail comprising at least one power connection, at least one power source, at least one rail accessory comprising a rail grabber or mount, wherein the at least one rail accessory receives electrical power from the power source. |
| FILED | Thursday, December 03, 2020 |
| APPL NO | 17/110981 |
| CURRENT CPC | Smallarms, e.g Pistols, Rifles; Accessories Therefor F41C 23/16 (20130101) F41C 27/00 (20130101) Original (OR) Class Weapon Sights; Aiming F41G 11/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318116 | Adelson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Edward Adelson (Winchester, Massachusetts); Branden Romero (Brighton, Massachusetts); Filipe Fernandes Veiga (Cambridge, Massachusetts) |
| ABSTRACT | A retrographic sensor includes a transparent structure, a transparent elastomeric pad, and an at least partially reflective layer. One or more light sources emit light into a side surface of the transparent structure. The light undergoes internal reflection in the transparent structure and is reflected toward a camera oriented toward the transparent structure. The at least partially reflective layer may be semi-specular in some embodiments. |
| FILED | Thursday, October 15, 2020 |
| APPL NO | 17/071301 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/24 (20130101) Original (OR) Class Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/24 (20130101) Electric Digital Data Processing G06F 3/016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318120 | Lentz et al. |
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| FUNDED BY |
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| APPLICANT(S) | US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Lentz (Niceville, Florida); Kevin Brink (Fort Walton Beach, Florida) |
| ABSTRACT | A compact celestial tracker includes a platform, a rotation stage that rotatably coupled to the platform to rotate a plane of the platform about a rotation axis and that supports the platform on a substrate, an off-axis parabolic mirror mounted to one side of the platform and having a focal plane directed at an acute angle that is between the rotation axis and the plane of the platform to reflect and focus the beam at a point above another side of the platform, and a detector coupled to the other side of the platform to receive and detect the reflected and focused beam. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/192978 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/025 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 5/10 (20130101) G02B 19/0019 (20130101) G02B 19/0076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318184 | Alford et al. |
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| FUNDED BY |
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| APPLICANT(S) | TDA Research, Inc. (Wheat Ridge, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M Alford (Lakewood, Colorado); David P Eisenberg (Denver, Colorado); Girish Srinivas (Broomfield, Colorado) |
| ABSTRACT | A thermally luminescent temperature sensor with a rare earth emitter having a first selective electromagnetic light energy emission band and a second selective electromagnetic light energy emission band in which the rare earth emitter converts thermal energy to electromagnetic light energy within the first and second selective energy emission bands. The sensor also has a selective optical detector in optical communication with the rare earth emitter, wherein the selective optical detector independently detects each the first and second selective electromagnetic light energy emission bands. Lastly, the thermally luminescent temperature sensor determines the temperature based on the electromagnetic light energy measured within the first and second selective energy emission bands relative to each other. Optionally additional emission bands may be used in the evaluation of the temperature. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/267298 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7706 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/3213 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318185 | Hubble |
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| FUNDED BY |
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| APPLICANT(S) | David O. Hubble (King George, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | David O. Hubble (King George, Virginia) |
| ABSTRACT | A calorimeter board is provided for power calibration of a laser emission. The board includes a flat metal plate, a sinuous groove and a resistance temperature detector wire. The flat metal plate has obverse and reverse surfaces separated by a thickness. The groove is cut into the reverse surface and penetrates to a depth being part of the thickness. The wire is disposed within the groove at the depth. The wire connects to an instrument that measures electrical resistance responsive to the laser emission on the obverse surface. |
| FILED | Wednesday, April 08, 2020 |
| APPL NO | 16/842950 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/16 (20130101) G01K 17/003 (20130101) G01K 19/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318231 | Mavrikakis et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emmanouil Mavrikakis (Middleton, Wisconsin); Nicholas Abbott (Lansing, New York); Tibor Szilvasi (Madison, Wisconsin); Nanqi Bao (Ithaca, New York); Huaizhe Yu (Ithaca, New York); Jake Gold (Madison, Wisconsin) |
| ABSTRACT | Liquid crystal-based devices for detecting a target contaminant in air, including hydrogen, nitrogen dioxide, ozone, ammonia or carbon monoxide, and methods of using such devices to detect the target contaminant are disclosed. Such devices have a substrate surface that includes one or more metals or metal alloys that is in contact with a liquid crystal composition. When the device is contacted with a sample that contains the target contaminant, an observed change in the orientational ordering of the liquid crystal signals the presence of the target contaminant. In the absence of the target contaminant, no change in orientational ordering occurs. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353271 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) Original (OR) Class G01N 21/783 (20130101) G01N 21/8806 (20130101) G01N 31/223 (20130101) G01N 2021/1704 (20130101) G01N 2021/8848 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318235 | Terracciano et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony Terracciano (Orlando, Florida); Robert Peale (Orlando, Florida); Christopher Arose (Orlando, Florida); Subith Vasu (Orlando, Florida) |
| ABSTRACT | A method and device which can receive and identify electromagnetic radiation in the terahertz (THz) frequency range. The device has a combination of material and geometric parameters that are unique and tunable, enabling resonating frequencies for spectral selectivity in the THz range (0.1-15) with ultra-narrow channel widths (0.01-0.10 THz) full width at half maximum (FWHM). Dependent upon configuration, the device may be employed as a large area resonator to collect weak or diffuse signals or as a constituent of an array able to take pictures within the spectrum for which they are sensitive. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/228801 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/34 (20130101) G01J 2005/345 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/3581 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 37/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318272 | BOWERS, II et al. |
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| FUNDED BY |
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| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. BOWERS, II (Sykesville, Maryland); Don A. HARRIS (Columbia, Maryland); Tadd C. KIPPENY (Pasadena, Maryland) |
| ABSTRACT | A system and method for utilizing a carbide-derived carbon (CDC) fiber in solid-phase micro extraction. Optically pumping the carbide-derived carbon (CDC) fiber, as compared to using thermal desorption, enhances performance of the system. CDC provides for a broad based sorbent that is insensitive to high humidity. Optical pumping may be done axially or radially on a modified gas chromatography needle. In some cases, staged, or pulsed, optical pumping is used to drive off solvent or other lower boiling compounds first and then the desorption of the remaining analytes is cleaner and the instrumentation is less likely to be overloaded. |
| FILED | Wednesday, September 05, 2018 |
| APPL NO | 17/268551 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/12 (20130101) Original (OR) Class G01N 30/18 (20130101) G01N 30/30 (20130101) G01N 2030/025 (20130101) G01N 2030/128 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318276 | Rubenstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | H. Mitchell Rubenstein (Beavercreek, Ohio); Patrick Lewis (Alburquerque, New Mexico) |
| ABSTRACT | A system for solventless calibration of volatile or semi-volatile compounds and methods thereof. The system includes a fluid path having a first end configured to be operably coupled to a fluid source and a second end configured to be operably coupled to the analytical instrument. A solid sorbent is disposed along the fluid path and is configured to absorb an analyte. The flow of fluid along the fluid path from the first end to the second end causes absorbed analyte to be desorbed from the solid sorbent at a desired concentration to the instrument. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/356795 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) B01J 20/262 (20130101) B01J 2220/54 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/12 (20130101) G01N 30/93 (20130101) G01N 30/482 (20130101) G01N 30/8665 (20130101) Original (OR) Class G01N 2030/328 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318296 | Johnson-Buck et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Johnson-Buck (Ann Arbor, Michigan); Muneesh Tewari (Ann Arbor, Michigan); Nils G. Walter (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein is technology relating to detecting analytes and particularly, but not exclusively, to methods, compositions and systems for detecting, characterizing, identifying, and/or quantifying analytes. |
| FILED | Tuesday, July 23, 2019 |
| APPL NO | 17/259601 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) G01N 33/542 (20130101) Original (OR) Class G01N 33/557 (20130101) G01N 33/5302 (20130101) G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318487 | Beranek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Beranek (Hollywood, Maryland); John Diehl (Clinton, Maryland); Jason McKinney (Bowie, Maryland) |
| ABSTRACT | A multicore fiber optic cable comprising of a dual core optical fiber having a dual core optical fiber geometry, the cores are spiraled parallel to one another along the longitudinal axis of the fiber to negate link path length difference, a coating that surrounds the fiber, a buffer tube that surrounds the coated fiber, a strength member that surrounds the buffer tube, and an outer jacket that surrounds the strength member. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162220 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/02042 (20130101) Original (OR) Class G02B 6/02047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318505 | Beranek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Navy (Patuxent River, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Beranek (Hollywood, Maryland); Jordan Hollady (Lexington Park, Maryland); John Diehl (Clinton, Maryland); Jason McKinney (Bowie, Maryland) |
| ABSTRACT | A multicore fiber optic cable comprising of a central fiber having a central fiber outer diameter, a central fiber coating surrounding the central fiber outer diameter of the central fiber, the central fiber coating having a continuous spiraled groove around the central fiber outer diameter, a dual core optical fiber having a dual core optical fiber geometry, the dual core optical fiber spiraled around the central fiber coating and disposed within the spiraled groove such that the dual core optical fiber is wound around the central fiber coating in a spiral pattern and the central fiber core geometry and the dual core optical fiber geometry are oriented longitudinally to negate link path length difference; and an outer sheath surrounding the central fiber coating and the dual core optical fiber. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/161098 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/443 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318516 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Samsung Electronics Co., Ltd. (Suwon-si, South Korea); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | Samsung Electronics Co., Ltd. (Suwon-si, South Korea); California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Seunghoon Han (Seoul, South Korea); Amir Arbabi (Pasadena, California); Andrei Faraon (Pasadena, California); Sungwoo Hwang (Seoul, South Korea); Jangwoo You (Seoul, South Korea); Byounglyong Choi (Seoul, South Korea) |
| ABSTRACT | An optical system and an image sensor including the same are provided. The optical system includes first, second, and third optical devices. At least one of the first, second, and third optical devices is a thin-lens including nanostructures. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167849 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 3/08 (20130101) G02B 5/1876 (20130101) G02B 9/10 (20130101) G02B 9/12 (20130101) G02B 9/14 (20130101) Original (OR) Class G02B 13/003 (20130101) G02B 13/18 (20130101) G02B 13/0035 (20130101) G02B 13/0055 (20130101) G02B 27/0025 (20130101) G02B 2207/101 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 999/99 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318587 | VOIGT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Chris VOIGT (Cambridge, Massachusetts); Di Sheng LEE (Cambridge, Massachusetts) |
| ABSTRACT | A colored composition having a self-assembly of a plurality of a peptide and melanin, and methods of producing and using the colored composition are described. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228637 |
| CURRENT CPC | Peptides C07K 7/06 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 61/00 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/167 (20130101) Original (OR) Class G02F 1/1676 (20190101) G02F 2001/1678 (20130101) G02F 2202/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318670 | CUNNINGHAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert CUNNINGHAM (Lexington, Massachusetts); Benjamin KAISER (Cambridge, Massachusetts); Margaret BONING (Cambridge, Massachusetts); Jeffrey BRANDON (Cambridge, Massachusetts); Alice LEE (Cambridge, Massachusetts) |
| ABSTRACT | A method for mediating an interaction between a control station and a remote system includes maintaining, at a command monitor, data characterizing an operation of the remote system in response to execution of commands at the remote system, receiving, at the command monitor, state information from the remote system, updating the data characterizing the operation of the remote system based on the received state information, receiving, at the command monitor, one or more commands sent from the control station, determining a predicted set of one or more outcomes that would result from execution of the one or more commands at the remote system based at least in part on the data characterizing the operation of the remote system, and preventing issuance of at least one command of the one or more commands at the remote system based on the predicted set of one or more outcomes. |
| FILED | Tuesday, July 03, 2018 |
| APPL NO | 16/026266 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/41835 (20130101) Original (OR) Class G05B 19/41855 (20130101) G05B 19/41885 (20130101) G05B 2219/25274 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0825 (20130101) H04L 9/3273 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319122 | Sadeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Norman Sadeh (Pittsburgh, Pennsylvania); Bin Liu (Pittsburgh, Pennsylvania); Anupam Das (Pittsburgh, Pennsylvania); Martin Degeling (Pittsburgh, Pennsylvania); Florian Schaub (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system and method configures permission settings for applications (“apps”) running on a computing device of a user. A data center generates at least one model of collective privacy preferences. The computing device is in communication with the data center via a communications network. The computing device comprises a processor that execute at least a first app that requests access to at least one permission of the computing device and a personal privacy assistant app. The personal privacy assistant app receives the at least one model from the one or more servers of the data center; collects information about the user; identifies at least one recommended permission setting for the first app based on the at least one model and such that the recommended permission setting is user-specific; and configures the computing device to implement the received at least one user-specific recommended permission setting. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165775 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/604 (20130101) Original (OR) Class G06F 21/629 (20130101) G06F 21/6245 (20130101) Computer Systems Based on Specific Computational Models G06N 7/00 (20130101) G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/101 (20130101) H04L 63/102 (20130101) H04L 67/12 (20130101) H04L 67/22 (20130101) H04L 67/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319146 | Reinhart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Siemens Industry Software Inc. (Plano, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wesley Reinhart (Plainsboro, New Jersey); Lucia Mirabella (Plainsboro, New Jersey); Suraj Ravi Musuvathy (Princeton Junction, New Jersey) |
| ABSTRACT | Methods and systems are disclosed for generation of cellular lattice kernels optimized by multiple objectives for highly specific targeted properties of geometry and topology rather than state of the art methods that rely on a predefined kernel library. Using a characterization of virtual kernel features, bulk material properties can be predicted using approximations from the virtual kernel rather than having to rely solely on experimental finite element simulations of lattice structures. |
| FILED | Friday, September 06, 2019 |
| APPL NO | 17/273869 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/10 (20200101) Original (OR) Class G06F 30/27 (20200101) Computer Systems Based on Specific Computational Models G06N 3/126 (20130101) G06N 5/003 (20130101) G06N 5/04 (20130101) G06N 20/20 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319606 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Mohit Gupta (Madison, Wisconsin); Sizhuo Ma (Madison, Wisconsin) |
| ABSTRACT | In accordance with some embodiments, systems, methods and media for high dynamic range quanta burst imaging are provided. In some embodiments, the system comprises: an image sensor comprising single photon detectors in an array; a processor programmed to: generate a sequence of binary images representing a scene; divide the sequence of binary images into blocks; generate block-sum images from the blocks; determine alignments between the block-sum images and a reference block-sum image; warp the sequence of binary images based on the alignments; generate warped block-sum images using warped binary images; merge the warped block-sum images; display a final image of the scene based on the merged warped block-sum images. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 16/844899 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/0093 (20130101) G06T 5/009 (20130101) G06T 5/20 (20130101) G06T 7/30 (20170101) G06T 11/60 (20130101) Original (OR) Class G06T 2207/20208 (20130101) G06T 2207/20221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319633 | Korchev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOEING COMPANY (Chicago, Illinois) |
| ASSIGNEE(S) | THE BOEING COMPANY (, None) |
| INVENTOR(S) | Dmitriy Korchev (Irvine, California); Charles E. Martin (Santa Monica, California); Tsai-Ching Lu (Thousand Oaks, California); Steve C. Slaughter (Scottsdale, Arizona); Alice A. Murphy (Mesa, Arizona); Derek Samuel Fok (Mesa, American Samoa) |
| ABSTRACT | A method includes obtaining sensor data captured by a sensor of an aircraft during a power up event. The sensor data includes multiple parameter values, each corresponding to a sample period. The method further includes determining a set of delta values, each indicating a difference between parameter values for consecutive sample periods of the sensor data. The method further includes determining a set of quantized delta values by assigning the delta values to quantization bins based on magnitudes of the delta values. The method further includes determining a normalized count of delta values for each quantization bin. The method further includes comparing the normalized counts of delta values to anomaly detection thresholds. The method further includes generating, based on the comparisons, output indicating whether the sensor data is indicative of an operational anomaly. |
| FILED | Wednesday, April 08, 2020 |
| APPL NO | 16/843220 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 45/00 (20130101) B64D 2045/0085 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/60 (20170101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/008 (20130101) G07C 5/0808 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319636 | Bharadwaj et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | Honeywell International Inc. (, None) |
| INVENTOR(S) | Raj Mohan Bharadwaj (Maple Grove, Minnesota); Kyusung Kim (Plymouth, Minnesota); Kwong Wing Au (Bloomington, Minnesota); Paul Frederick Dietrich (Brooklyn Park, Minnesota); Piyush Ranade (Minneapolis, Minnesota); Andrew Peter Vechart (Plymouth, Minnesota); Megan Hawley (Roseville, Minnesota); Abraham Reddy (Minneapolis, Minnesota); Craig Schimmel (Rio Rancho, Minnesota); David Daniel Lilly (Ramona, California) |
| ABSTRACT | A method in an aircraft of using prognostic indicators for aircraft maintenance includes retrieving aircraft health data for a plurality of aircraft components wherein the aircraft health data includes at least one of mechanical systems condition indicator (CI) data, vibration spectrum data, resampled time-domain (RTD) data, and RTD spectrum data. The method includes estimating component health status information for the plurality of aircraft components using a plurality of prognostic modules wherein each prognostic module is configured to generate health status information for at least one of the aircraft components, the health status information includes at least one of a current health indicator and a prognostic indicator. The method also includes storing the component health status information for the aircraft components in a database onboard the aircraft, and causing the display of the health status information for the specific component on an aircraft display. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/155364 |
| CURRENT CPC | Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/60 (20170101) Electric Digital Data Processing G06F 16/22 (20190101) G06F 16/955 (20190101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/0816 (20130101) Original (OR) Class G07C 5/0841 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320183 | Varghese et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Varghese (Woburn, Massachusetts); Timothy Grotjohn (Okemos, Michigan); Michael Geis (Acton, Massachusetts) |
| ABSTRACT | In some embodiments, a semiconductor structure can include: a diamond substrate having a surface conductive layer; a heavily doped region formed in the diamond substrate; and a metal contact positioned over the conductive surface layer such that a first portion of the heavily doped region is covered by the metal contact and a second portion of the heavily doped region is not covered by the metal contact. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 16/844907 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/042 (20130101) H01L 21/043 (20130101) H01L 21/0415 (20130101) H01L 21/02527 (20130101) H01L 21/02579 (20130101) H01L 29/45 (20130101) Original (OR) Class H01L 29/167 (20130101) H01L 29/0847 (20130101) H01L 29/1602 (20130101) H01L 29/66045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320270 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yongxi Li (Ann Arbor, Michigan); Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | A photovoltaic cell comprises an anode, a cathode, a first subcell positioned between the anode and the cathode, the first subcell comprising a first donor material and a first acceptor material, and a second subcell positioned between the first subcell and the cathode, the second subcell comprising a second donor material and a second acceptor material. A method of fabricating a photovoltaic cell is also described. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/036472 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 5/006 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0046 (20130101) H01L 51/0067 (20130101) H01L 51/441 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210321052 | Cossairt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); Peking University (Beijing, China PRC) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oliver Strider Cossairt (Evanston, Illinois); Boxin Shi (Beijing, China PRC); Zihao Wang (Evanston, Illinois); Peiqi Duan (Beijing, China PRC); Aggelos K. Katsaggelos (Chicago, Illinois); Tiejun Huang (Beijing, China PRC) |
| ABSTRACT | An imaging system includes an event camera configured to capture a first image of a scene. The system also includes a shutter camera collocated with the event camera, where the shutter camera is configured to capture a second image of the scene. The system also includes a processor operatively coupled to the event camera and the shutter camera. The processor is configured to apply guided event filtering (GEF) on the first image and the second image. The processor is also configured to generate a third image based on filtering of the first image and the second image. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/227691 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 5/2352 (20130101) H04N 5/2353 (20130101) H04N 5/2354 (20130101) H04N 5/23222 (20130101) H04N 5/35563 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210315402 | Howard |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Panit Clifton Howard (Albuquerque, New Mexico) |
| ABSTRACT | A donning system allows a user to don disposable garments without contaminating the exterior of the garment. The disposable garment is part of a garment package, which also includes a cuff by which the garment is loaded into and dispensed from the donning system. The cuff includes elements whereby multiple garments are simultaneously loaded, but the garments are dispensed and donned one at a time. The donning system can include multiple cartridges allowing the user to don multiple garments simultaneously, such as right and left gloves or shoe covers. The donning system can include multiple chambers allowing the system to dispense garments of different sizes. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/165996 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 19/0055 (20130101) A41D 2400/44 (20130101) A41D 2400/52 (20130101) Characteristic Features of Footwear; Parts of Footwear A43B 3/163 (20130101) Household or Table Equipment A47G 25/80 (20130101) A47G 25/904 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315822 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Jacob Ongudi Agola (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Jacob Ongudi Agola (Albuquerque, New Mexico) |
| ABSTRACT | Methods of preparing red blood cell mimetics and functionalized red blood cell mimetics, and methods of making and using those mimetics, are provided. |
| FILED | Tuesday, July 30, 2019 |
| APPL NO | 17/264452 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1273 (20130101) Original (OR) Class A61K 9/1277 (20130101) A61K 35/18 (20130101) A61K 47/6913 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0641 (20130101) C12N 2527/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315929 | Rozhkova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elena A. Rozhkova (Lemont, Illinois); Elena Shevchenko (La Grange, Illinois) |
| ABSTRACT | Products and methods for redirecting the pathological biochemical process of accumulation of reduced pyridine nucleotides under deleterious hypoxia conditions toward the reduction of the precursor salt and the biosynthesis of biologically compatible, antioxidant noble metal nanoparticles and the simultaneous restoring of the tissue redox state are provided. The products and methods have application in the treatment of hypoxia and hypoxia-related diseases and disorders. Such products and methods are also useful in organ transplantation and recovery, in screening of anti-hypoxia agents, and in detecting elevated levels of the reducing equivalents of the redox state, for example, NADH, NADPH, GSH, and TrxSH2, in cells, tissues, or organs. |
| FILED | Wednesday, April 08, 2020 |
| APPL NO | 16/843114 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5115 (20130101) A61K 33/242 (20190101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/06 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316002 | Ellis |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Christopher Ellis (Knoxville, Tennessee) |
| ABSTRACT | The present disclosure is directed to compositions and methods for targeted drug delivery that comprise a biocompatible framework carrying at least one drug and a viral surface protein, where the viral surface protein mediates entry into a target cell and is attached to an outer surface of the biocompatible framework in the drug carrier. |
| FILED | Tuesday, April 14, 2020 |
| APPL NO | 16/848397 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 9/0019 (20130101) A61K 9/107 (20130101) A61K 9/127 (20130101) A61K 45/06 (20130101) A61K 47/64 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316276 | GRIFFIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Brandon GRIFFIN (Denver, Colorado); Calvin MUKARAKATE (Arvada, Colorado); Maarit Kristiina IISA (Golden, Colorado); Abhijit DUTTA (Littleton, Colorado); Joshua A. SCHAIDLE (Arvada, Colorado); Andrew Nolan WILSON (Denver, Colorado); Mark R. NIMLOS (Golden, Colorado); Matthew Maurice Yung (Denver, Colorado) |
| ABSTRACT | The present disclosure relates to a catalyst that includes a support that includes a metal oxide and a metal deposited on the support, where the metal oxide includes at least one of TiO2, Al2O3, SiO2, CeO2, and/or ZrO2, the metal includes at least one of Pt, Pd, Ru Rh, Ni, and/or Mo, the metal is in the form of a particle, and the metal is present on the support at a concentration between about 0.1 wt % and about 5.0 wt %. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/191370 |
| CURRENT CPC | Separation B01D 53/02 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/063 (20130101) B01J 23/42 (20130101) Original (OR) Class B01J 35/08 (20130101) B01J 35/1014 (20130101) B01J 35/1038 (20130101) B01J 35/1042 (20130101) B01J 35/1057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316340 | GENG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (NEWPORT NEWS, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RONGLI GENG (Yorktown, Virginia) |
| ABSTRACT | A method and apparatus for removing microscopic contaminant particulates by high pressure liquid nitrogen jet cleaning from the inner surface of a superconducting radio frequency cavity or a string of multiple cavities and transporting the removed particulates out of the inner space enclosed by the cleaned surfaces. The cleaning method of the invention suppresses field emission, resulting in an increase of the usable accelerating gradient of the cavities and a reduction of the activated radioactivity in accelerator components around cavities. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/156981 |
| CURRENT CPC | Cleaning in General; Prevention of Fouling in General B08B 3/02 (20130101) B08B 7/0021 (20130101) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316350 | Joshi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Vineet V. Joshi (Richland, Washington); Scott A. Whalen (West Richland, Washington); Curt A. Lavender (Richland, Washington); Glenn J. Grant (Benton City, Washington); MD. Reza-E-Rabby (Richland, Washington); Aashish Rohatgi (Richland, Washington); Jens T. Darsell (West Richland, Washington) |
| ABSTRACT | A process for forming extruded products using a device having a scroll face configured to apply a rotational shearing force and an axial extrusion force to the same preselected location on material wherein a combination of the rotational shearing force and the axial extrusion force upon the same location cause a portion of the material to plasticize, flow and recombine in desired configurations. This process provides for a significant number of advantages and industrial applications, including but not limited to extruding tubes used for vehicle components with 50 to 100 percent greater ductility and energy absorption over conventional extrusion technologies, while dramatically reducing manufacturing costs. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175464 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/002 (20130101) B21C 23/08 (20130101) B21C 23/142 (20130101) B21C 23/215 (20130101) B21C 23/218 (20130101) B21C 25/02 (20130101) Original (OR) Class B21C 27/00 (20130101) B21C 29/003 (20130101) B21C 33/00 (20130101) B21C 37/155 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 2301/058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316501 | Boyce et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brad Boyce (Albuquerque, New Mexico); Benjamin C. White (Albuquerque, New Mexico); Anthony Garland (Albuquerque, New Mexico); Ryan Alberdi (Albuquerque, New Mexico) |
| ABSTRACT | Multi-body interpenetrating lattices comprise two or more lattices that interlace or interpenetrate through the same volume without any direct physical connection to each other, wherein energy transfer is controlled by surface interactions. As a result, multifunctional or composite-like responses can be achieved by additive manufacturing of the interpenetrating lattices, even with only a single print material, with programmable interface-dominated properties. As a result, the interpenetrating lattices can have unique mechanical properties, including improved toughness, multi-stable/negative stiffness, and electromechanical coupling. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/189074 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/37 (20210101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) Original (OR) Class B29C 70/0035 (20210501) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317026 | Thomson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bruce Thomson (Albuquerque, New Mexico); Kerry Howe (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, None) |
| INVENTOR(S) | Bruce Thomson (Albuquerque, New Mexico); Kerry Howe (Albuquerque, New Mexico) |
| ABSTRACT | A novel process for treatment of low quality or brackish water that allows increased recovery of high quality water, recovers commodity minerals and reduces the volume of water and mass of solids that are disposed from the process. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/301617 |
| CURRENT CPC | Compounds of Alkali Metals, i.e Lithium, Sodium, Potassium, Rubidium, Caesium, or Francium C01D 3/06 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 5/14 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/20 (20130101) C02F 9/00 (20130101) Original (OR) Class Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 11/264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317170 | Ellis |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Christopher Ellis (Knoxville, Tennessee) |
| ABSTRACT | The present disclosure is directed to compositions and methods for targeted drug delivery that comprise a biocompatible framework carrying at least one drug and a viral surface protein, where the viral surface protein mediates entry into a target cell and is attached to an outer surface of the biocompatible framework in the drug carrier. |
| FILED | Monday, November 02, 2020 |
| APPL NO | 17/086957 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/107 (20130101) A61K 9/1271 (20130101) A61K 47/6911 (20170801) Peptides C07K 14/165 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317234 | LUO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juntao LUO (Jamesville, New York); Wei HE (Davis, California); Kit S. LAM (Davis, California); Paul HENDERSON (Dublin, California); Matthew A. COLEMAN (Oakland, California) |
| ABSTRACT | The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer, each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308921 |
| CURRENT CPC | Peptides C07K 14/775 (20130101) C07K 17/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317364 | Zaitseva et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Natalia P. Zaitseva (Livermore, California); M Leslie Carman (San Ramon, California); Andrew M. Glenn (Livermore, California); Andrew Neil Mabe (Livermore, California) |
| ABSTRACT | A scintillator material includes a polymer matrix, a primary dye in the polymer matrix, the primary dye being a fluorescent dye; a secondary dye, and a Li-containing compound in the polymer matrix, where the Li-containing compound is a Li salt of a short-chain aliphatic acid. In addition, the scintillator material exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225429 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 69/109 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 2211/1088 (20130101) Measurement of Nuclear or X-radiation G01T 1/2006 (20130101) G01T 1/2033 (20130101) G01T 3/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317466 | Brandizzi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Federica Brandizzi (Okemos, Michigan); Sang Jin Kim (Okemos, Michigan); Starla Zemelis-Durfee (Dewitt, Michigan) |
| ABSTRACT | Described herein are expression cassettes, plant cells, plant seeds, plants, and methods useful for improving the glucan content and growth of plants. |
| FILED | Friday, May 03, 2019 |
| APPL NO | 17/051683 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8245 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317481 | Das et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY AND ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lalitendu Das (Emeryville, California); Hemant Choudhary (Emeryville, California); John M. Gladden (Alameda, California); Blake A. Simmons (San Francisco, California) |
| ABSTRACT | The present invention also provides for a method to deconstruct a biomass: the method comprising: (a) introducing a solvent to a biomass to dissolve at least part of solid biomass in the solvent, wherein the solvent comprises (i) a metal salt, and (ii) an ionic liquid (IL) or deep eutectic solvent (DES), or mixture thereof, to form a solubilized biomass mixture; (b) optionally introducing an enzyme and/or a microbe to the composition such that the enzyme and/or microbe produce a biofuel and/or chemical compound from the solubilized biomass; and, (c) optionally the biofuel and/or chemical compound is separated from the composition. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/220846 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/10 (20130101) Original (OR) Class C12P 19/02 (20130101) C12P 19/14 (20130101) C12P 2201/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317494 | Quinlan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jason Quinlan (Woodland, California); Feng Xu (Davis, California); Matthew Sweeney (Sacramento, California); Don Higgins (Franklinton, North Carolina); Hui Xu (Wake Forest, North Carolina) |
| ASSIGNEE(S) | NOVOZYMES NORTH AMERICA, INC. (Franklinton, North Carolina); NOVOZYMES, INC. (Davis, California) |
| INVENTOR(S) | Jason Quinlan (Woodland, California); Feng Xu (Davis, California); Matthew Sweeney (Sacramento, California); Don Higgins (Franklinton, North Carolina); Hui Xu (Wake Forest, North Carolina) |
| ABSTRACT | The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a liquor. The present invention also relates to methods of using the compositions. |
| FILED | Friday, August 05, 2011 |
| APPL NO | 13/814912 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2437 (20130101) C12N 9/2445 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/02 (20130101) C12P 19/14 (20130101) Original (OR) Class C12P 2203/00 (20130101) Enzymes C12Y 302/01004 (20130101) C12Y 302/01021 (20130101) Saccharides Obtained From Natural Sources or by Hydrolysis of Naturally Occurring Disaccharides, Oligosaccharides or Polysaccharides C13K 1/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317548 | Williamson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Energy, United States Department of (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. Williamson (Naperville, Illinois); James L. Willit (Batavia, Illinois); Stanley G. Wiedmeyer (Glen Ellyn, Illinois); Terry R. Johnson (Wheaton, Illinois); Javier Figueroa (Andover, Kansas); Terry Alan Cruise (Lisle, Illinois) |
| ABSTRACT | According to one aspect of the invention, a system to separate salt from uranium. The system has a vessel, a heater, a pump, and a condenser. The vessel is adapted to receive a uranium that has a salt concentration. The heater heats the uranium for a period of time, causing the salt to turn into a salt vapor and the uranium to melt. The melted uranium releases the salt vapor. The pump circulates an inert gas that carries the salt vapor away from the melted uranium. The condenser is adapted to receive the salt vapor. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 16/845558 |
| CURRENT CPC | Separation B01D 1/0011 (20130101) B01D 1/14 (20130101) B01D 1/0082 (20130101) B01D 5/006 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 60/0213 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317586 | Liang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Siwei Liang (Dublin, California); Sarah E. Baker (Dublin, California); Theodore F. Baumann (Discovery Bay, California); Eric B. Duoss (Dublin, California); Christopher M. Spadaccini (Oakland, California); Cheng Zhu (Livermore, California) |
| ABSTRACT | An ink formulation and electrode that enhances hydrogen production, oxygen production, carbon dioxide reduction and other electrocatalytic reactions. Embodiments include an ink formulation with polymer binders having different catalytical precursors and a 3D electrode produced by additive manufacturing from the inventor's ink formulation. Various embodiments of the inventor's apparatus, systems, and methods provide inks that that are 3D-printed into patterns that optimize surface area and flow. The catalytic materials are imbedded into the ink matrix which is then printed into a 3D structure that has architecture that optimizes surface area and flow properties. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 16/845985 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/02 (20130101) C25B 9/08 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0656 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317587 | Biener et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| INVENTOR(S) | Monika M. Biener (San Leandro, California); Juergen Biener (San Leandro, California); Siwei Liang (Dublin, California); Zhen Qi (Tracy, California); Michael Stadermann (Pleasanton, California); Vedasri Vedharathinam (Fremont, California) |
| ABSTRACT | A flow-through electrolysis cell includes a hierarchical nanoporous metal cathode. A method of reducing CO2 includes flowing the CO2 through the hierarchical nanoporous metal cathode of the flow-through electrolysis cell. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354664 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/25 (20210101) C25B 9/19 (20210101) C25B 11/031 (20210101) C25B 11/057 (20210101) Original (OR) Class C25B 11/061 (20210101) C25B 15/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317984 | Rapp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vi Rapp (Berkeley, California); Peter Therkelsen (Portland, Oregon) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to burner apparatus for lean premixed flames. In one aspect, an apparatus includes a burner plate, a burner body, and a mesh. A first surface of the burner plate defines a combustion surface for a fuel/air mixture. The burner plate defines a plurality of primary ports. The burner body defines a fuel-air mixing chamber. One surface of the burner body comprises the burner plate. The burner body defines an inlet for receiving air and a fuel in the fuel-air mixing chamber. The mesh is disposed in the fuel-air mixing chamber and is in contact with a second surface of the burner plate. |
| FILED | Wednesday, February 10, 2021 |
| APPL NO | 17/172298 |
| CURRENT CPC | Burners F23D 14/02 (20130101) F23D 14/26 (20130101) Original (OR) Class F23D 14/62 (20130101) F23D 2203/102 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318130 | Klenk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Klenk (San Francisco, California); Victoria M. Bellotti (Oakland, California); Shiwali Mohan (Palo Alto, California) |
| ABSTRACT | Systems and methods described receive a request for a transportation plan for a user, wherein the request comprises a starting point and an ending point for a route. Systems and methods then generate a set of potential transportation plans for the route, determine an impact of a subset of plans in the set of potential transportation plans and estimate a likelihood of acceptance of the subset of plans in the set of potential transportation plans based on a personal preference model for the user. Systems and methods also select an influence strategy of the user based on a user model and generate a message recommending a selected plan from the subset of plans for the user, wherein the message is generated based on the selected influence strategy. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354820 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3461 (20130101) G01C 21/3484 (20130101) Original (OR) Class G01C 21/3605 (20130101) G01C 21/3676 (20130101) G01C 21/3697 (20130101) Electric Digital Data Processing G06F 16/29 (20190101) G06F 16/2379 (20190101) G06F 16/24575 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318229 | Burak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Michael Forrest Simpson (, None); The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Burak (Ann Arbor, Michigan); Michael Forrest Simpson (Murray, Utah) |
| ABSTRACT | A reference electrode includes a metal body, a lead disposed within the metal body, an insulator disposed between the lead and the metal body, the insulator including a ceramic material, and a porous metal chamber coupled to the metal body, the lead extending into the porous metal chamber. The porous metal chamber is configured to maintain an electrolyte solution within the porous metal chamber to establish a redox couple with the lead. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181294 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 17/02 (20130101) Original (OR) Class G01N 17/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318401 | Sorte et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mark S. Conradi (Albuquerque, New Mexico); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Glenn Sorte (Albuquerque, New Mexico); Mark S. Conradi (Albuquerque, New Mexico); Brennan J. Walder (Albuquerque, New Mexico); Todd M. Alam (Cedar Crest, New Mexico) |
| ABSTRACT | Electrochemical devices with metal casings have been considered incompatible with nuclear magnetic resonance (NMR) spectroscopy because the oscillating magnetic fields (“rf fields”) responsible for excitation and detection of NMR active nuclei do not penetrate metals. According to the present invention, rf fields can still efficiently penetrate into nonmetallic layers of electrochemical cells (such as a coin cell battery configuration) provided the magnetic field is oriented tangentially to the electrochemical cell electrodes in a “skimming” orientation. As an example, noninvasive high field in situ 7Li and 19F NMR of an unmodified commercial off-the-shelf rechargeable coin cell was demonstrated using a traditional external NMR coil setup. The in operando NMR measurements revealed that irreversible physical changes accumulate at the anode during electrochemical cycling. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165099 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/12 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4616 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318691 | AMINI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Reza AMINI (Ann Arbor, Michigan); Yiheng FENG (Ann Arbor, Michigan); Zhen YANG (Ann Arbor, Michigan); Ilya KOLMANOVSKY (Ann Arbor, Michigan); Jing SUN (Superior Township, Michigan) |
| ABSTRACT | An integrated speed prediction framework based on historical traffic data mining and real-time V2I communications for CAVs. The present framework provides multi-horizon speed predictions with different fidelity over short and long horizons. The present multi-horizon speed prediction is integrated with an economic model predictive control (MPC) strategy for the battery thermal management (BTM) of connected and automated electric vehicles (EVs) as a case study. The simulation results over real-world urban driving cycles confirm the enhanced prediction performance of the present data mining strategy over long prediction horizons. Despite the uncertainty in long-range CAV speed predictions, the vehicle level simulation results show that 14% and 19% energy savings can be accumulated sequentially through eco-driving and BTM optimization (eco-cooling), respectively, when compared with normal-driving and conventional BTM strategy. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225577 |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 1/0221 (20130101) G05D 1/0223 (20130101) G05D 1/0278 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/44 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319184 | Williamson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (Newport News, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Williamson (Hampton, Virginia); David Lawrence (Newport News, Virginia); Kishansingh Rajput (Newport News, Virginia) |
| ABSTRACT | A method for analyzing existing digital files to recognize sensitive data in the textual content. The method includes extracting features describing the environmental context in which a file was created and the file content itself and modeling and analyzing pairwise relations between text that exist within a given file; the text itself; and characteristics that exist about the text in relation to the entire file. The method takes the extracted features, including the data itself and its context, and analyzes this data with artificial intelligence (AI) algorithms such as decision trees and neural networks to predict whether a document includes sensitive data. Leveraging AI algorithms rather than discrete algorithms carries with it the advantage of being able to handle massive volumes of data, as well as the ever increasing varieties of data. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196312 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/253 (20200101) G06F 40/295 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319308 | Sankaranarayanan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Subramanian Sankaranarayanan (Naperville, Illinois); Troy David Loeffler (Chicago, Illinois); Henry Chan (Schaumburg, Illinois) |
| ABSTRACT | A method for active learning using sparse training data can include training a machine learning model using less than ten first training data points to generate a candidate machine learning model. The method can include performing a Monte Carlo process to sample one or more first outputs of the candidate machine learning model. The method can include testing the one or more first outputs to determine if each of the one or more first outputs satisfy a respective convergence condition. The method can include, responsive to at least one first output not satisfying the respective convergence condition, training the candidate machine learning model using at least one second training data point corresponding to the at least one first output. The method can include, responsive to the one or more first outputs each satisfying the respective convergence condition, outputting the candidate machine learning model. |
| FILED | Monday, April 13, 2020 |
| APPL NO | 16/847098 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319919 | Besmann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Theodore M. Besmann (Oak Ridge, Tennessee); Emily E. Moore (Livermore, California) |
| ABSTRACT | Described herein are Uranium silicide materials as advanced nuclear fuel replacements for uranium dioxide fuel in light water reactors (LWRs) that have advantages over currently used uranium dioxide (UO2) via a substantially higher thermal conductivity and, thus, are capable of operating in a reactor at significantly lower temperatures for the same level of power production, plus the heat capacity of a silicide is lower than that of an oxide so that less heat is stored in the fuel that would need to be removed under accident conditions. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/174618 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 33/06 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/30 (20130101) C01P 2004/61 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/51 (20130101) C04B 35/5158 (20130101) C04B 2235/3891 (20130101) Nuclear Reactors G21C 3/623 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320047 | ROAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Deere and Company (Moline, Illinois); Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | Deere and Company (Moline, Illinois); Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | Thomas J. ROAN (Fargo, North Dakota); Brij N. SINGH (West Fargo, North Dakota); Gilberto MORENO (Thornton, Colorado); Kevin Scott BENNION (Littleton, Colorado) |
| ABSTRACT | Provided is an evaporator stack. The evaporator stack may be used in power-dense electronic assemblies. The evaporator stack includes a lower floor including at least one mounded portion, and an enclosure surrounding the lower floor, wherein a height of the enclosure is greater than a height of the at least one mounded portion, the at least one mounded portion extending between two walls of the enclosure. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/018255 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/427 (20130101) Original (OR) Class H01L 23/4332 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320270 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yongxi Li (Ann Arbor, Michigan); Stephen R. Forrest (Ann Arbor, Michigan) |
| ABSTRACT | A photovoltaic cell comprises an anode, a cathode, a first subcell positioned between the anode and the cathode, the first subcell comprising a first donor material and a first acceptor material, and a second subcell positioned between the first subcell and the cathode, the second subcell comprising a second donor material and a second acceptor material. A method of fabricating a photovoltaic cell is also described. |
| FILED | Tuesday, September 29, 2020 |
| APPL NO | 17/036472 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 5/006 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0046 (20130101) H01L 51/0067 (20130101) H01L 51/441 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320292 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guiliang Xu (Naperville, Illinois); Xiang Liu (Darien, Illinois); Khalil Amine (Oakbrook, Illinois) |
| ABSTRACT | A [PxSbyMz]p/[carbon]q composite where x, y, and z represent atomic percentage values and are x>0; y>0; and z≥0, M is an electrically conductive metal, p and q represent the weight percentage values of the composite wherein p and q are in the range of 0-100%, and is p>0. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 16/844485 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/1673 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 4/623 (20130101) H01M 10/054 (20130101) H01M 10/0525 (20130101) H01M 10/0569 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320293 | LIPSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert L. LIPSON (Oak Park, Illinois); Jessica L. DURHAM (Braidwood, Illinois) |
| ABSTRACT | A method for recovering and recycling a cathode active material comprises combining a cathode waste from a lithium battery cathode waste stream with lithium-containing compound (e.g., lithium hydroxide) to form a reaction mixture; wherein the cathode waste comprises carbon, a fluorinated polymeric binder, and a cathode material selected from the group consisting of a lithiated cathode material and a delithiated cathode material; heating the reaction mixture in a stream of oxygen-containing gas to a temperature and for a period of time sufficient to burn off the carbon and the binder, to lithiate any delithiated cathode material present in the cathode waste, and for lithium in the reaction mixture to capture fluoride formed from decomposition of the binder; cooling the reaction mixture to ambient room temperature; and recovering the lithiated cathode active material. |
| FILED | Monday, April 13, 2020 |
| APPL NO | 16/846967 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 2/1673 (20130101) H01M 4/131 (20130101) H01M 4/133 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/0471 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/623 (20130101) H01M 4/661 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320298 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Apple Inc. (Cupertino, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongli Dai (Los Altos, California); Huiming Wu (San Jose, California); Chi-Kai Lin (Sunnyvale, California); Michael J. Erickson (San Jose, California); Martin Bettge (Santa Clara, California); Xiaoping Wang (Naperville, Illinois); Yan Li (Westmont, Illinois); Yanjie Cui (Arlington Heights, Illinois); James A. Gilbert (Bolingbrook, Illinois); Zhenzhen Yang (Godfrey, Illinois); Anh D. Vu (Lemont, Illinois); Arthur Jeremy Kropf (Westmont, Illinois); Hakim H. Iddir (Hoffman Estates, Illinois); Christopher S. Johnson (Naperville, Illinois); John David Carter (Bolingbrook, Illinois) |
| ABSTRACT | The disclosure provides a plurality of particles. Each particle may include a material comprising 0.95 to 1.30 mole fraction Li, at least 0.60 and less than 1.00 mole fraction Co, up to 10,000 ppm Al, 1.90 to 2.10 mole fraction O, and up to 0.30 mole fraction M, where M is at least one element selected from B, Na, Mg, P, Ti, Ca, V, Cr, Fe, Mn, Ni, Cu, Zn, Al, Sc, Y, Ga, Zr, Ru, Mo, La, Si, Nb, Ge, In, Sn, Sb, Te, and Ce. Each particle may also include a surface composition comprising a mixture of LiF and a metal fluoride. An amount of fluorine (F) is greater than 0 and less than or equal to 5000 ppm. The metal fluoride comprises a material selected from the group consisting of AlF3, CaF2, MgF2, and LaF2. The surface composition may also include a metal oxide comprising a material selected from the group consisting of TiO2, MgO, La2O3, CaO, and Al2O3. An amount of the metal oxide is greater than 0 and less than or equal to 20000 ppm. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226511 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0471 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/582 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320321 | Bock et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Anton Bock (Albuquerque, New Mexico); Erik David Spoerke (Albuquerque, New Mexico); Harlan James Brown-Shaklee (Albbuquerque, New Mexico); Leo J. Small (Albuquerque, New Mexico) |
| ABSTRACT | A sodium-ion conducting NaSICON ceramic can be densified via the addition of a solvent to a NaSICON powder and subsequent pressing under high pressure and mild heat. Densification to ˜90% relative density can be achieved, providing a path toward low-temperature fabrication of Na-ion conductors. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/153607 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/447 (20130101) C04B 35/645 (20130101) C04B 35/6264 (20130101) C04B 2235/447 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/054 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320328 | Visco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | PolyPlus Battery Company (Berkeley, California) |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Alexei Petrov (Walnut Creek, California); Valentina Loginova (Walnut Creek, California); Vitaliy Nimon (San Francisco, California); Yevgeniy S. Nimon (Danville, California); Bruce D. Katz (Moraga, California) |
| ABSTRACT | Preparation of anhydrous lithium sulfide (Li2S) purified suitably for applications in advanced batteries, and, in particular, for synthesis of solid electrolytes based on Li2S, including sulfide solid electrolytes of the type that may be described as crystalline (e.g., polycrystalline), amorphous (e.g., glass) and combinations thereof, such as sulfide glass-ceramic solid electrolyte materials. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/249864 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) G01N 21/896 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/0407 (20130101) H01M 4/1395 (20130101) H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 10/0566 (20130101) H01M 50/46 (20210101) H01M 50/403 (20210101) H01M 50/431 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320587 | YU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianghui YU (Blacksburg, Virginia); Rolando BURGOS (Blacksburg, Virginia) |
| ABSTRACT | Various examples of power converters including Integrated Capacitor Blocked Transistor (ICBT) cells and methods of control of power converters having ICBT cells are described. In one example, a power converter includes an upper arm including a plurality of upper ICBT cells connected in series to form a series connection path and a lower arm including a plurality of lower ICBT cells connected in series in the series connection path. A controller can be configured to provide a control signal pair to each of the upper ICBT cells and a complementary control signal pair to each of the lower ICBT cells to control the converter output. A capacitor voltage controller can be configured to balance a voltage potential among ICBT capacitors in at least one of the upper arm and the lower arm. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 16/844514 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/08 (20130101) H02M 1/38 (20130101) H02M 3/158 (20130101) Original (OR) Class H02M 2001/0009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320597 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Seung-Wuk Lee (Walnut Creek, California); Byung Yang Lee (Seoul, South Korea) |
| ABSTRACT | The present invention provides for a modified virus, such as a recombinant M13 phage, which in an array, such as a film, is capable of producing piezoelectricity. The modified virus comprises a coat protein can displays a negatively charged amino acid sequence. The present invention provides for a device comprising a piezoelectric element comprising a suitable virus, such as the modified virus, a first surface and a second surface, wherein the first surface is in contact with a first electrode and the second surface is in contact with a second electrode, wherein when pressure is applied to the film, the film is capable of generating an electric current. The present invention provides for a method of making the device, and a method for generating electricity using the device. |
| FILED | Friday, May 10, 2013 |
| APPL NO | 13/892148 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2795/00021 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/0474 (20130101) H01L 41/0478 (20130101) Electric Machines Not Otherwise Provided for H02N 2/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210321198 | Zettl et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander K. Zettl (Kensington, California); Stephen M. Gilbert (Albany, California); Donez J. Horton-Bailey (El Cerrito, California); Hu Long (El Cerrito, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to acoustic transducers. |
| FILED | Tuesday, August 06, 2019 |
| APPL NO | 17/266539 |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 7/06 (20130101) Original (OR) Class H04R 7/18 (20130101) H04R 19/02 (20130101) H04R 19/005 (20130101) H04R 2307/023 (20130101) H04R 2307/204 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210321537 | COUSINEAU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Deere and Company (Moline, Illinois); Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | Deere and Company (Moline, Illinois); Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | Emily COUSINEAU (Lakewood, Colorado); Gilberto MORENO (Thornton, Colorado); Kevin Scott BENNION (Littleton, Colorado); Thomas J. ROAN (Fargo, North Dakota); Brij N. SINGH (West Fargo, North Dakota) |
| ABSTRACT | Provided is a condenser for use in an electronic assembly. The condenser includes a first vertical wall extending in a vertical direction, the first vertical wall defining a first plurality of vertical condensation channels within the first vertical wall, a second vertical wall extending in the vertical direction, the second vertical wall defining a second plurality of vertical condensation channels within the second vertical wall, and a first plurality of fins extending in the vertical direction, each of the first plurality of fins connected to the first vertical wall, the second vertical wall or both the first vertical wall and the second vertical wall. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 16/870320 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 39/04 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/427 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20145 (20130101) H05K 7/20172 (20130101) H05K 7/20309 (20130101) H05K 7/20318 (20130101) Original (OR) Class H05K 7/20327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210315527 | Pequito et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sergio Pequito (Delft, Netherlands); Orlando Romero (Philadelphia, Pennsylvania); Sarthak Chatterjee (Endicott, New York) |
| ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| INVENTOR(S) | Sergio Pequito (Delft, Netherlands); Orlando Romero (Philadelphia, Pennsylvania); Sarthak Chatterjee (Endicott, New York) |
| ABSTRACT | One embodiment provides a system controller circuitry for mitigating a neurophysiological disorder. The system controller circuitry includes an optimization module, a feedback control module, and a model update module. The optimization module is configured to predict a sequence of control inputs based, at least in part, on a fractional order model of a neurophysiological system. A duration of the predicted sequence of control inputs corresponds to a prediction horizon. The feedback control module is configured to provide at least a portion of the sequence of control inputs to the neurophysiological system based, at least in part, on a current state of the neurophysiological system. A duration of the at least a portion corresponds to a control horizon. The model update module is configured to update one or more of a model parameter and/or an objective function parameter at an update interval, based, at least in part, on a recent state of the neurophysiological system. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/228775 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/7203 (20130101) A61B 5/7221 (20130101) A61B 5/7275 (20130101) Original (OR) Class A61B 5/7282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315763 | Varghese et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Harmonic Bionics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rohit John Varghese (Austin, Texas); William Wu (Austin, Texas) |
| ABSTRACT | An embodiment includes an apparatus for coupling a user to a robot to provide robot-assisted physical therapy to the user. Other embodiments are described herein. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230154 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/78 (20130101) A61F 2/583 (20130101) A61F 2002/543 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0285 (20130101) Original (OR) Class A61H 2201/1638 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316044 | Zlotnick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hannah M. Zlotnick (Philadelphia, Pennsylvania); Andrew Todd Clark (North Wales, Pennsylvania); Robert L. Mauck (Philadelphia, Pennsylvania); Xuemei Cheng (Bryn Mawr, Pennsylvania) |
| ABSTRACT | The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229829 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/042 (20130101) A61L 27/045 (20130101) A61L 27/46 (20130101) A61L 27/047 (20130101) A61L 27/52 (20130101) A61L 27/222 (20130101) A61L 27/225 (20130101) A61L 27/3847 (20130101) Original (OR) Class A61L 27/3852 (20130101) A61L 2300/41 (20130101) A61L 2300/43 (20130101) A61L 2300/258 (20130101) A61L 2300/402 (20130101) A61L 2300/406 (20130101) A61L 2300/408 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316450 | Torabi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | 3DEO, Inc. (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Payman Torabi (Los Angeles, California); Matthew Petros (Los Angeles, California); Zhuofeng Zhang (Los Angeles, California) |
| ABSTRACT | The present disclosure provides systems and methods for training a robot. The systems and methods may provide a robotic system. The robotic system may comprise a trainable robot and a sensor. The sensor may be attached to at least one physical tool. The method may comprise using the sensor to capture movement from a user operating the at least one physical tool. The method may include using at least the movement captured to train the robot, such that upon training, the robot may be trained to perform at least the movement. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175510 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/163 (20130101) Original (OR) Class B25J 9/1664 (20130101) B25J 9/1697 (20130101) B25J 13/089 (20130101) B25J 15/0019 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/227 (20170801) B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316509 | Malhan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rishi Malhan (Los Angeles, California); Timotei Centea (Los Angeles, California); Satyandra Gupta (Los Angeles, California); Ariyan Kabir (Los Angeles, California); Brual Shah (Los Angeles, California); Aniruddha Shembekar (Los Angeles, California) |
| ABSTRACT | Methods, systems, and robots for multi-layer prepreg composite sheet layup. The method includes obtaining a dataset including start and end point pairs of a mold of the 3D part. The method includes generating a layup sequence based on the dataset and generating multiple trajectories for one or more movements of the first robot or the first robot arm based on the layup sequence. The method includes causing a second robot or a second robot art to hold or grasp the prepreg layer or sheet a threshold distance above the mold or the 3D part. The method includes causing the first robot or the first robot arm to place or conform the prepreg layer or sheet to the mold of the 3D part. |
| FILED | Wednesday, August 07, 2019 |
| APPL NO | 17/260031 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/0087 (20130101) B25J 11/005 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/379 (20170801) Original (OR) Class B29C 64/393 (20170801) B29C 70/386 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317010 | HSIAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin S. HSIAO (Setauket, New York); Priyanka SHARMA (East Setauket, New York); Sunil Kumar SHARMA (East Setauket, New York); Ken I. JOHNSON (Port Jefferson Station, New York) |
| ABSTRACT | A method of treating contaminated water, such as wastewater, with carboxylated cellulose to remove ammonium and nitrogen-containing impurities is claimed. Carboxylated cellulose extracted by nitro-oxidation has negatively-charged functionality and forms an aggregate when exposed to positively-charged impurities in contaminated water. The aggregate, nitrogen-containing impurities, and by-products from the nitro-oxidation process can be isolated to provide a fertilizer or fertilizer component. |
| FILED | Wednesday, August 28, 2019 |
| APPL NO | 17/267683 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/24 (20130101) B01J 20/28023 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/286 (20130101) Original (OR) Class C02F 2101/16 (20130101) Organic Fertilisers Not Covered by Subclasses C05B, C05C, e.g Fertilisers From Waste or Refuse C05F 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317068 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | OHIO UNIVERSITY (ATHENS, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | XIAOZHUO CHEN (ATHENS, Ohio); STEPHEN BERGMEIER (ATHENS, Ohio) |
| ABSTRACT | Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/348985 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/09 (20130101) A61K 45/06 (20130101) Acyclic or Carbocyclic Compounds C07C 39/367 (20130101) C07C 43/23 (20130101) C07C 43/253 (20130101) C07C 205/32 (20130101) Original (OR) Class C07C 211/48 (20130101) C07C 235/56 (20130101) Heterocyclic Compounds C07D 209/08 (20130101) C07D 231/12 (20130101) C07D 233/64 (20130101) C07D 235/18 (20130101) C07D 249/08 (20130101) C07D 311/16 (20130101) C07D 311/82 (20130101) C07D 319/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317149 | Lopez-Mejias et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vilmali Lopez-Mejias (San Juan, Puerto Rico); Lesly Y. Carmona-Sarabia (San Juan, Puerto Rico); Andrea M. Escalera Joy (San Juan, Puerto Rico); Darilys Mojica Vazquez (San Juan, Puerto Rico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vilmali Lopez-Mejias (San Juan, Puerto Rico); Lesly Y. Carmona-Sarabia (San Juan, Puerto Rico); Andrea M. Escalera Joy (San Juan, Puerto Rico); Darilys Mojica Vazquez (San Juan, Puerto Rico) |
| ABSTRACT | The invention provides extended bisphosphonate-based metal complexes using benzene1,4-bis(bisphosphonic acid) (BBPA), an analog of benzene 1,4-dicarboxylic acid (BDC). Hydrothermal synthesis of BBPA with the bioactive metals Ca2+, Zn2+, and Mg2+ leads to four crystals phases, namely, BBPA-Ca forms I and II, BBPA-Zn form I, and BBPA-Mg form I. Out of the three structures, BBPA-Ca form II presents large channels (8 Å×12 Å), potentiating the use of this framework to load drugs. Dissolution profiles were conducted to investigate the release of BBPA from BBPA-based metal complexes under physiological conditions (phosphate-buffered saline, PBS). These results show that <50% of BBPA was released from the BBPA-based metal complexes after 72 h. Binding assays employing hydroxyapatite (HA) were conducted to explore the affinity of BBPA to the bone microenvironment. About 99% of the BBPA could bind to HA in 10 days, revealing that BBPA is capable of binding to the bone. Cytotoxicity effects of BBPA was elucidated in a human breast cancer MDA-MB-231 and a normal osteoblast hFOB 1.19 cell lines. The half-maximal inhibitory concentration (IC50) for BBPA used to treat both cell lines were >200 μM at 24, 48, and 72 h of treatment. The BBPA in the range of concentration employed (0-200 μM) was no cytotoxic against these cell lines. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228629 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/386 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317370 | MEENAKSHISUNDARAM |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | RAVI SHANKAR MEENAKSHISUNDARAM (ASPINWALL, Pennsylvania) |
| ABSTRACT | An optically transparent actuator apparatus is provided that includes an optically transparent bi-stable member including an optically transparent liquid crystalline polymer layer. The bi-stable member is structured to move from a first state to a second state in response to a first stimulus and from the second state to the first state in response to a second stimulus. Also, a display apparatus includes a plate member and an actuator assembly coupled to the plate member. The actuator assembly includes a number of optically transparent liquid crystalline polymer layers, wherein each of the optically transparent liquid crystalline polymer layers is structured to move from a first state to a second state in response to a first stimulus. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308186 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/38 (20130101) Original (OR) Class C09K 19/0208 (20130101) C09K 2219/03 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/065 (20130101) Electric Digital Data Processing G06F 3/016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317381 | Chung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yip-Wah Chung (Wilmette, Illinois); Qian Jane Wang (Mount Prospect, Illinois); Qiang Ma (Evanston, Illinois); Arman Mohammad Khan (Evanston, Illinois) |
| ABSTRACT | A lubricant composition includes a base lubricant and a plurality of lubricant additive molecules functioning as precursor molecules to induce tribopolymerization and forming in situ protective tribofilm with desirable robustness and low shear resistance. Each lubricant additive molecule includes one or more surface-active groups attractable to target surface, and a carbon containing component operable connected to the one or more surface active groups. The carbon containing component comprise a carbon ring structure having a high ring strain that is metastable and activatable with a ring-opening reaction. A less stable carbon ring structure is more readily activated to the intermediate state, preferable to form more active fragments. Increasing the adsorption strength further is beneficial to prolonging the residence time of additive molecules on the target surface, thereby facilitating the dissociation of molecules and subsequent polymerization. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/228920 |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 129/32 (20130101) C10M 129/34 (20130101) C10M 177/00 (20130101) Original (OR) Class C10M 2207/122 (20130101) C10M 2207/123 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2070/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317397 | EPSTEIN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Slava EPSTEIN (Dedham, Massachusetts) |
| ABSTRACT | High capacity, low cost devices for use in growing monocultures of novel, previously unknown microbial species contain adhesive layers with wells covered by nanoporous membranes. The devices are placed in natural environments for cultivation of unknown microbial species. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228528 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/14 (20130101) C12M 23/24 (20130101) C12M 29/04 (20130101) Original (OR) Class C12M 37/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317479 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Tyson Shepherd (Cambridge, Massachusetts); Rémi Veneziano (Cambridge, Massachusetts); Mark Bathe (Cambridge, Massachusetts); Ian Slaymaker (Cambridge, Massachusetts); Bernd Zetsche (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed are compositions and methods involving nucleic acid assemblies that enclose and/or protect cargo. Disclosed are compositions that include a nucleic acid assembly comprising one or more nucleic acid molecules and cargo comprising two or more cargo molecules. The nucleic acid assembly can have physiochemical properties that: (i) enhance targeting of the composition to one or more types of cells, tissues, organs, or microenvironments relative to other types of cells, tissues, organs, or microenvironments in vivo; (ii) enhance stability and/or half-life of the composition in vivo; and/or (iii) reduce immunogenicity of the composition. The nucleic acid assembly and/or cargo can have features that enhance intracellular trafficking of nucleic acid assembly and/or its cargo. The cargo can be enclosed and/or protected by the nucleic acid assembly. Some or all of the cargo molecules in the composition can be present in a defined stoichiometric ratio. |
| FILED | Friday, September 06, 2019 |
| APPL NO | 17/273999 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/513 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/88 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317527 | Doudna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Janice S. Chen (Berkeley, California); Lucas Benjamin Harrington (Berkeley, California) |
| ABSTRACT | The present disclosure provides labeled single stranded detector DNA molecules that provide a sensitive readout for detection of a target DNA. The present disclosure provides compositions, systems, and kits comprising a labeled single stranded detector DNA of the present disclosure. The present disclosure further provides methods of detecting a target DNA (double stranded or single stranded) in a sample. |
| FILED | Monday, August 26, 2019 |
| APPL NO | 17/270215 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) C12Q 1/6844 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318178 | CASSELLA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cristian CASSELLA (Boston, Massachusetts); Hussein HUSSEIN (Boston, Massachusetts); Matteo RINALDI (Boston, Massachusetts) |
| ABSTRACT | A sensing device is provided having sensing circuitry, connected to an input port and the output port, with a sensor having an impedance sensitive to a parameter of interest, one or more passive electrical components, and a variable capacitor. The sensing circuitry is triggered to generate an output signal for transmission from the output port, the output signal dependent on the parameter of interest sensed by the sensor and on an input power value, Pin, of an input signal received at the input port being greater than a parametric threshold power value, Pth. A sensing system includes the sensing device and a transmitting device to transmit the input signal to the sensing device at a frequency representative of the parameter of interest. A receiving device, which can be incorporated with or located remotely from the transmitting device, receives the output signal of the sensing device, which has a frequency that is half of the frequency of the input signal transmitted by the transmitting device. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226182 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/22 (20130101) Original (OR) Class G01K 7/34 (20130101) Transmission H04B 5/0031 (20130101) H04B 5/0062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318231 | Mavrikakis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emmanouil Mavrikakis (Middleton, Wisconsin); Nicholas Abbott (Lansing, New York); Tibor Szilvasi (Madison, Wisconsin); Nanqi Bao (Ithaca, New York); Huaizhe Yu (Ithaca, New York); Jake Gold (Madison, Wisconsin) |
| ABSTRACT | Liquid crystal-based devices for detecting a target contaminant in air, including hydrogen, nitrogen dioxide, ozone, ammonia or carbon monoxide, and methods of using such devices to detect the target contaminant are disclosed. Such devices have a substrate surface that includes one or more metals or metal alloys that is in contact with a liquid crystal composition. When the device is contacted with a sample that contains the target contaminant, an observed change in the orientational ordering of the liquid crystal signals the presence of the target contaminant. In the absence of the target contaminant, no change in orientational ordering occurs. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353271 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) Original (OR) Class G01N 21/783 (20130101) G01N 21/8806 (20130101) G01N 31/223 (20130101) G01N 2021/1704 (20130101) G01N 2021/8848 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318288 | Drndic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marija Drndic (Philadelphia, Pennsylvania); Yung-Chien Chou (Philadelphia, Pennsylvania) |
| ABSTRACT | Provided are nanopore devices that include a hafnium oxide coating on the pores of the devices. Such devices exhibit improved stability, especially when in a salt solution environment. Also provided are related methods. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/218365 |
| CURRENT CPC | Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00087 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318290 | Fu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Xiaoan Fu (Louisville, Kentucky); Michael Nantz (Louisville, Kentucky); Michael Bousamra (Louisville, Kentucky); Victor van Berkel (Louisville, Kentucky) |
| ABSTRACT | Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/238082 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/082 (20130101) A61B 5/091 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/72 (20130101) G01N 33/64 (20130101) G01N 33/497 (20130101) Original (OR) Class G01N 33/543 (20130101) G01N 33/574 (20130101) G01N 33/57484 (20130101) G01N 2033/4975 (20130101) G01N 2800/7028 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0031 (20130101) H01J 49/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318900 | Gopalan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Foundation for the State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kartik Gopalan (Vestal, New York); Hui Lu (Binghamton, New York) |
| ABSTRACT | Systems and methods for live updating virtualization systems are disclosed. One method may include identifying a container on a first virtual machine of a virtualization system. The container may include at least one process associated with performing a task on a first virtual machine. The method may also include determining a first communication path between the process included in the container on the first virtual machine and a hypervisor of the virtualization system, and migrating the container and the process included in the container to a second virtual machine. The second virtual machine may be distinct from the first virtual machine. Additionally, the method may include determining a second communication path between the process included in the migrated container on the second virtual machine and the hypervisor of the virtualization system. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/229996 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) Original (OR) Class G06F 2009/45583 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319122 | Sadeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Norman Sadeh (Pittsburgh, Pennsylvania); Bin Liu (Pittsburgh, Pennsylvania); Anupam Das (Pittsburgh, Pennsylvania); Martin Degeling (Pittsburgh, Pennsylvania); Florian Schaub (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system and method configures permission settings for applications (“apps”) running on a computing device of a user. A data center generates at least one model of collective privacy preferences. The computing device is in communication with the data center via a communications network. The computing device comprises a processor that execute at least a first app that requests access to at least one permission of the computing device and a personal privacy assistant app. The personal privacy assistant app receives the at least one model from the one or more servers of the data center; collects information about the user; identifies at least one recommended permission setting for the first app based on the at least one model and such that the recommended permission setting is user-specific; and configures the computing device to implement the received at least one user-specific recommended permission setting. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165775 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/604 (20130101) Original (OR) Class G06F 21/629 (20130101) G06F 21/6245 (20130101) Computer Systems Based on Specific Computational Models G06N 7/00 (20130101) G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/101 (20130101) H04L 63/102 (20130101) H04L 67/12 (20130101) H04L 67/22 (20130101) H04L 67/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319958 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gang WANG (Urbana, Illinois); Yaofeng CHEN (Chicago, Illinois); Joseph W. LYDING (Champaign, Illinois) |
| ABSTRACT | A method of making a carbon-metal oxide composite electrode for a supercapacitor includes continuously injecting a carbon material solution into a coagulation solution, where the carbon material solution comprises a carbon source and a liquid, and the coagulation solution comprises a metal nitrate or chloride and an organic solvent. An extruded structure comprising the metal nitrate or chloride interspersed with carbon is formed from the continuous injection. The extruded structure is annealed under conditions sufficient to convert the metal nitrate or chloride to metal oxide. Thus, a composite structure comprising the metal oxide and the carbon is formed, where the metal oxide is uniformly dispersed within the composite structure. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224450 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/06 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/32 (20130101) Original (OR) Class H01G 11/46 (20130101) H01G 11/56 (20130101) H01G 11/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320173 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pinshane Huang (Urbana, Illinois); Arend van der Zande (Urbana, Illinois); Elif Ertekin (Urbana, Illinois); Edmund Han (Champaign, Illinois); Jaehyung Yu (Chicago, Illinois); Mohammad Abir Hossain (Urbana, Illinois) |
| ABSTRACT | A method of making a deformable electronic device comprises forming a multilayer device structure comprising functional layers on a flexible substrate. At least one, some or all of the functional layers comprises a stack of 2D monolayers, and a number or proportion of misaligned interfaces within each stack of 2D monolayers is controlled to obtain a predetermined bending stiffness. Each of the misaligned interfaces comprises a twist angle and/or lattice mismatch between adjacent 2D monolayers. The functional layers may include electronically active layers and other layers having a dielectric, insulating, and/or protective function. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226331 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/22 (20130101) H01L 29/24 (20130101) H01L 29/0684 (20130101) Original (OR) Class H01L 29/1606 (20130101) H01L 29/7606 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320305 | Roberts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Clemson University (Clemson, South Carolina) |
| ASSIGNEE(S) | Clemson University (, None) |
| INVENTOR(S) | Mark E. Roberts (Clemson, South Carolina); Robert K. Emmett (Clemson, South Carolina); Stephen E. Creager (Clemson, South Carolina) |
| ABSTRACT | Provided herein is a redox flow battery comprising an anode comprising anodic redox mediators; a negative electrolyte tank comprising an anolyte; and an anode pump capable of circulating the anolyte through the anode. The redox flow battery further comprises a cathode comprising cathodic redox mediators; a positive electrolyte tank comprising a catholyte and a cathode pump capable of circulating the catholyte through the cathode. A separator is between the anode and cathode. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224429 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/9008 (20130101) Original (OR) Class H01M 8/08 (20130101) H01M 8/188 (20130101) H01M 2004/8684 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320329 | Hu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan-Yan Hu (Tallahassee, Florida); Po-Hsiu Chien (Tallahassee, Florida); Xuyong Feng (Tallahassee, Florida); Sawankumar Patel (Tallahassee, Florida); Pengbo Wang (Tallahassee, Florida) |
| ABSTRACT | Solid electrolytes, including lithium-argyrodite solid electrolytes, and electronic devices, such as lithium-ion batteries that include the solid electrolytes. Methods of making solid electrolytes, including methods for making solid electrolytes with varying degrees of lithium deficiency. |
| FILED | Friday, August 09, 2019 |
| APPL NO | 17/267303 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0562 (20130101) Original (OR) Class H01M 2300/008 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210320808 | Piestun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafael Piestun (Boulder, Colorado); Haiyan Wang (Boulder, Colorado) |
| ABSTRACT | Systems and methods for azimuthal multiplexing using three-dimensional diffractive optics An azimuthal optical multiplexing system includes a light source. The system includes two or more at least partially transparent plates. Each plate of the two or more plates has a structured or patterned surface positioned in an optical path of the light source. The system includes means for rotating at least one plate of the two or more plates axially with respect to at least one other plate of the two or more plates. The means for rotating is operatively coupled to the at least one plate. The structured or patterned surface is configured to modulate light directed along the optical path and through the two or more plates. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230892 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/4233 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210315821 | Migrino et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond Q. Migrino (Phoenix, Arizona); Seth Truran (Pheonix, Arizona); Nina Karamanova (Laveen, Arizona); Volkmar Weissig (Glendale, Arizona); Jillian Madine (Liverpool, United Kingdom); Hannah Davies (Liverpool, United Kingdom) |
| ABSTRACT | Disclosed herein are compositions comprising nanoliposomes useful for the treatment and prevention of cerebrovascular and aging-related degenerative diseases. |
| FILED | Friday, August 09, 2019 |
| APPL NO | 17/267738 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/1272 (20130101) Original (OR) Class A61K 38/1709 (20130101) A61K 47/24 (20130101) A61K 47/26 (20130101) A61K 47/28 (20130101) A61K 47/6849 (20170801) A61K 47/6913 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/586 (20130101) G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315895 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Beibei Chen (Sewickley, Pennsylvania); Rama K. Mallampalli (Sewickley, Pennsylvania) |
| ABSTRACT | A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; and R1-R10 are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R3 or R8 is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 16/953201 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 31/341 (20130101) A61K 31/381 (20130101) A61K 31/402 (20130101) A61K 31/427 (20130101) A61K 31/435 (20130101) A61K 31/444 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/4155 (20130101) A61K 31/4178 (20130101) A61K 31/4418 (20130101) A61K 31/5375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) A61P 11/06 (20180101) A61P 19/00 (20180101) A61P 25/00 (20180101) A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 211/01 (20130101) C07C 211/53 (20130101) C07C 229/38 (20130101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 211/14 (20130101) C07D 213/06 (20130101) C07D 213/36 (20130101) C07D 213/38 (20130101) C07D 231/12 (20130101) C07D 233/61 (20130101) C07D 233/64 (20130101) C07D 239/26 (20130101) C07D 265/30 (20130101) C07D 277/28 (20130101) C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315985 | Perera et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Washington, District of Columbia); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Liyanage Parakrama Perera (Bethesda, Maryland); Thomas Alexander Waldmann (Bethesda, Maryland); Kevin Charles Conlon (Bethesda, Maryland); Pin-Yu Perera (Washington, District of Columbia) |
| ABSTRACT | A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353054 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) A61K 31/7076 (20130101) A61K 35/17 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 16/2866 (20130101) C07K 2317/24 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316044 | Zlotnick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hannah M. Zlotnick (Philadelphia, Pennsylvania); Andrew Todd Clark (North Wales, Pennsylvania); Robert L. Mauck (Philadelphia, Pennsylvania); Xuemei Cheng (Bryn Mawr, Pennsylvania) |
| ABSTRACT | The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229829 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/042 (20130101) A61L 27/045 (20130101) A61L 27/46 (20130101) A61L 27/047 (20130101) A61L 27/52 (20130101) A61L 27/222 (20130101) A61L 27/225 (20130101) A61L 27/3847 (20130101) Original (OR) Class A61L 27/3852 (20130101) A61L 2300/41 (20130101) A61L 2300/43 (20130101) A61L 2300/258 (20130101) A61L 2300/402 (20130101) A61L 2300/406 (20130101) A61L 2300/408 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210316144 | Ganguly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karunesh Ganguly (San Francisco, California); Tanuj Gulati (San Francisco, California); Dhakshin S. Ramanathan (San Diego, California) |
| ABSTRACT | Systems, methods and devices for promoting recovery from a stroke induced loss of motor function in a subject. In certain aspects, the system includes at least one electrode, and an operations system in electrical communication with at least one electrode, wherein the at least one electrode is constructed and arranged to apply current across the brain of the subject and to record low frequency oscillations from a perilesional region of the subject. In certain aspects, provided is a method comprising placing at least one recording electrode in electrical communication in a perilesional region of the subject; placing at least one stimulation electrode in electrical communication with the brain of the subject; recording low frequency oscillations from the perilesional region of the subject; and delivering current stimulation to the brain of the subject. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/259760 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/313 (20210101) A61B 5/4836 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0531 (20130101) A61N 1/36103 (20130101) Original (OR) Class A61N 1/36171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210315186 | AZIMI-SADJADI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY SECRETARY OF AGRICULTURE (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mahmood R. AZIMI-SADJADI (Fort Collins, Colorado); John HALL (Fort Collins, Colorado); Christopher ROBBIANO (Fort Collins, Colorado); Kurt Christian VERCOUTEREN (Laporte, Colorado); Nathan Paul SNOW (Fort Collins, Colorado); Joseph Martin Halseth (Fort Collins, Colorado) |
| ABSTRACT | An apparatus and method for autonomous and accurate identification of target animal species, such as in animal species control and management systems for use in public or private agricultural and related communities. An intelligent, autonomous, dual-sensory, animal species-specific recognition system useful for activating wildlife management and related devices when a particular animal species approaches the system is provided. The device and method use a combination of both acoustic and visual sensors, together with efficient and robust recognition algorithms and signal/image processing techniques, to maximize accurate target-specific identification and reject false alarms. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230453 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 5/02 (20130101) A01K 29/00 (20130101) Original (OR) Class Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants A01M 25/002 (20130101) Veterinary Instruments, Implements, Tools, or Methods A61D 7/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00362 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210315208 | Koehler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip G. Koehler (Gainesville, Florida); Roberto M. Pereira (Gainesville, Florida); Christopher D. Batich (Gainesville, Florida) |
| ABSTRACT | Compositions, formulas, methods of making, mixing and applying insecticide formulations to different surfaces such as but not limited to interior surfaces of ovitraps, on walls and on chips and tiles to produce a texturized surface to allow for better transfer of the insecticidal active ingredients to insects, such as mosquitoes and the like, which land on or crawl on the surfaces, resulting in faster insect mortality rates. The texture of the insecticidal residue provides better transfer of the insecticidal active ingredients to insects that land on or crawl on the surface, resulting in faster insect mortality. The textured residue also enhances desirable surface characteristics for landing of mosquitoes and potentially other insects. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307466 |
| CURRENT CPC | Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants A01M 1/2016 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/04 (20130101) A01N 43/40 (20130101) Original (OR) Class A01N 53/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317471 | HEWEZI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | TAREK ABDELFATTAH HEWEZI (KNOXVILLE, Tennessee); SARBOTTAM PIYA (KNOXVILLE, Tennessee) |
| ABSTRACT | The invention relates to genes which may be utilized to induce resistance to soybean cyst nematode (SCN) and/or other abiotic or biotic stresses. More specifically the present disclosure provides genes that, when inactivated and/or overexpressed (for example, overexpression of genes encoding kinase-dead mutants) in a plant, particularly, a soybean plant, can confer upon the plant resistance to SCN and/or other abiotic or biotic stresses. Methods of using these genes to obtain plants, particularly soybean plants, that are resistant to SCN and/or other abiotic or biotic stresses are also provided. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/227472 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8285 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6895 (20130101) C12Q 2600/13 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210317472 | STRAUSS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Integrated Plant Genetics, Inc. (Gainesville, Florida); University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tina STRAUSS (Gainesville, Florida); Dean W. GABRIEL (Gainesville, Florida) |
| ABSTRACT | The present invention teaches methods and compositions useful for treating, preventing, or curing pathogen infections of living plants. In particular, the present invention teaches methods of enhancing plant response to pathogen-associated molecular patterns using RNA interference of plant genes. The methods and compositions described herein are effective at treating biotrophic pathogens, including Liberibacters. |
| FILED | Thursday, August 29, 2019 |
| APPL NO | 17/271938 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8218 (20130101) C12N 15/8286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20210316924 | Steed |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Darren Jay Steed (Egg Harbor Township, New Jersey) |
| ABSTRACT | The present application is directed to a packaging for a powdered explosive-detection training aid which may include first and second opposing flexible sheets heat sealed together along less than a periphery thereof and defining a storage compartment therebetween, wherein an unsealed portion of the periphery defines an opening to the storage compartment, wherein at least a portion of the first opposing flexible sheet is a semipermeable material permeable to a vapor emitted from the powdered explosive-detection training aid, with the second opposing flexible sheet being impermeable to the powdered explosive-detection training aid vapor; and a sealing member, wherein the sealing member is secured to the first opposing flexible sheet and, in a closing position, covers the semipermeable portion of the first opposing flexible sheet. |
| FILED | Tuesday, January 26, 2021 |
| APPL NO | 17/158905 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 15/02 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 33/01 (20130101) B65D 75/30 (20130101) Original (OR) Class B65D 85/70 (20130101) B65D 2565/388 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 11/132 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 8/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319642 | Boyd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Daniel A. Boyd (Arlington, Virginia); Kelli L. Biegger (McLean, Virginia); Chang Ellison (Arlington, Virginia); Brandon P. Gutierrez (Burke, Virginia); Jason Lim (Alexandria, Virginia); William Washington (North Potomac, Maryland); Arun Vemury (North Bethesda, Maryland); Nathan Grebasch (Fairfax, Virginia) |
| ABSTRACT | In an example, a method includes receiving, by an election office system from a voter device, a request for a voting ballot for an election, part or all of voter ID information associated with a first mobile identification credential which the voter device received from a first authorizing party system (APS), and consented data indication which indicates the part or all of voter ID information that is authorized by the voter device for release by the first APS to the election office system, the part or all of voter ID information to be verified to the election office system by the first APS; and using the verified part or all of voter ID information to verify or not verify an identity of the voter. The identity of the voter is to be verified before the election office system grants the request to provide the voting ballot to the voter. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228274 |
| CURRENT CPC | Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 13/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319862 | Boyd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Daniel A. Boyd (Arlington, Virginia); Kelli L. Biegger (McLean, Virginia); Chang Ellison (Arlington, Virginia); Brandon P. Gutierrez (Burke, Virginia); Jason Lim (Alexandria, Virginia) |
| ABSTRACT | In an example, a patient using a user mobile-identification-credential device (UMD) requests the patient's medical record from a medical office using a relying party system (RPS). The RPS requests identification information of the patient from the UMD and receives, based on consent of the patient, some or all patient identification information associated with a mobile identification credential (MIC) previously provisioned to the UMD an authorizing party system (APS). The RPS receives verification of the received patient identification information, uses the verified user ID information to verify or not verify the identity of the patient, and verifies the identity of the patient before granting the request to provide the medical record to the patient. The patient has the option of releasing part or all of the medical record to a third party. In one embodiment, the patient stores the medical record with a service provider and authorizes, in advance, certain medical personnel to have access to it. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167874 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/31 (20130101) G06F 21/62 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) Original (OR) Class G16H 15/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210321263 | Boyd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Daniel A. Boyd (Arlington, Virginia); Kelli L. Biegger (McLean, Virginia); Chang Ellison (Arlington, Virginia); Brandon P. Gutierrez (Burke, Virginia); Jason Lim (Alexandria, Virginia) |
| ABSTRACT | An embodiment includes a method to increase the efficiency of security checkpoint operations. A security checkpoint kiosk serves as a Relying Party System (RPS). The RPS establishes a secure local connection between the RPS and a User Mobile-Identification-Credential Device (UMD). The RPS sends a user information request to the UMD, via the secure local connection, seeking release of user information associated with a Mobile Identification Credential (MIC). The RPS obtains authentication of the user information received in response to the user information request. The RPS retrieves user travel information based on the user information. The RPS determines that the user travel information matches the user information. When the user travel information matches the user information, the RPS approves the user to proceed past the security checkpoint kiosk. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180509 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) Wireless Communication Networks H04W 4/80 (20180201) H04W 12/02 (20130101) H04W 12/037 (20210101) H04W 12/47 (20210101) H04W 12/69 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20210319939 | Kazemi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Mohammad Kazemi (Rochester, New York); Eby G. Friedman (Rochester, New York); Engin Ipek (Rochester, New York) |
| ABSTRACT | A method of controlling a trajectory of a perpendicular magnetization switching of a ferromagnetic layer using spin-orbit torques in the absence of any external magnetic field includes: injecting a charge current Je through a heavy-metal thin film disposed adjacent to a ferromagnetic layer to produce spin torques which drive a magnetization M out of an equilibrium state towards an in-plane of a nanomagnet; turning the charge current Je off after te seconds, where an effective field experienced by the magnetization of the ferromagnetic layer Heff is significantly dominated by and in-plane anisotropy Hkx, and where M passes a hard axis by precessing around the Heff; and passing the hard axis, where Heff is dominated by a perpendicular-to-the-plane anisotropy Hkz, and where M is pulled towards the new equilibrium state by precessing and damping around Heff, completing a magnetization switching. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231277 |
| CURRENT CPC | Static Stores G11C 11/18 (20130101) G11C 11/161 (20130101) G11C 11/1675 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/329 (20130101) H01F 10/3286 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 43/00 (20130101) H01L 43/04 (20130101) H01L 43/06 (20130101) H01L 43/10 (20130101) H01L 43/065 (20130101) Pulse Technique H03K 19/18 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 148/109 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210319973 | MONROE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher MONROE (Ellicott City, Maryland); Guido PAGANO (Washington, District of Columbia); Paul W. HESS (Middlebury, Vermont); Harvey B. KAPLAN (College Park, Maryland); Wen Lin TAN (College Park, Maryland); Philip J. RICHERME (Bloomington, Indiana) |
| ABSTRACT | The disclosure describes various aspects of a cryogenic trapped-ion system. In an aspect, a method is described that includes bringing a chain of ions in a trap at a cryogenic temperature, the trap being a micro-fabricated trap, and performing quantum computations, simulations, or both using the chain of ions in the trap at the cryogenic temperature. In another aspect, a method is described that includes establishing a zig-zag ion chain in the cryogenic trapped-ion system, detecting a change in a configuration of the zig-zag ion chain, and determining a measurement of the pressure based on the detection in the change in configuration. In another aspect, a method is described that includes measuring a low frequency vibration, generating a control signal based on the measurement to adjust one or more optical components, and controlling the one or more optical components using the control signal. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306301 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 37/08 (20130101) Original (OR) Class H01J 37/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210316874 | Resnick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Parallel Flight Technologies, Inc. (Ben Lomond, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Resnick (Ben Lomond, California); David Adams (Ben Lomond, California); Robert Hulter (Ben Lomond, California); Seth McGann (Ben Lomond, California); Brian Eiseman (Ben Lomond, California) |
| ABSTRACT | One variation of a system for generating thrust at an aerial vehicle includes: a primary electric motor; a rotor coupled to the motor; an internal-combustion engine; a clutch interposed between the motor and an output shaft of the internal-combustion engine; an engine shroud defining a shroud inlet between the rotor and the internal-combustion engine, extending over the internal-combustion engine, and defining a shroud outlet opposite the rotor; a cooling fan coupled and configured to displace air through the engine shroud; and a local controller configured to receive a rotor speed command specifying a target rotor speed, adjust a throttle setpoint of the internal-combustion engine according to the target rotor speed and a state of charge of a battery in the aerial vehicle, and drive the primary electric motor to selectively output torque to the rotor and to regeneratively brake the rotor according to the target rotor speed. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135735 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 7/10 (20130101) B60L 15/20 (20130101) B60L 58/12 (20190201) Aeroplanes; Helicopters B64C 27/32 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 27/26 (20130101) B64D 31/06 (20130101) Original (OR) Class B64D 33/08 (20130101) B64D 2027/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210318184 | Alford et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TDA Research, Inc. (Wheat Ridge, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John M Alford (Lakewood, Colorado); David P Eisenberg (Denver, Colorado); Girish Srinivas (Broomfield, Colorado) |
| ABSTRACT | A thermally luminescent temperature sensor with a rare earth emitter having a first selective electromagnetic light energy emission band and a second selective electromagnetic light energy emission band in which the rare earth emitter converts thermal energy to electromagnetic light energy within the first and second selective energy emission bands. The sensor also has a selective optical detector in optical communication with the rare earth emitter, wherein the selective optical detector independently detects each the first and second selective electromagnetic light energy emission bands. Lastly, the thermally luminescent temperature sensor determines the temperature based on the electromagnetic light energy measured within the first and second selective energy emission bands relative to each other. Optionally additional emission bands may be used in the evaluation of the temperature. |
| FILED | Friday, July 19, 2019 |
| APPL NO | 17/267298 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7706 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/3213 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20210316275 | ZHAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Auburn University (Auburn, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongye ZHAO (Auburn, Alabama); Wen LIU (Beijing, China PRC) |
| ABSTRACT | A composite comprises a carbonaceous and a metallic nanotube conjugated with a carbonaceous support. The composite may be used to remove contaminants from water. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196209 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/20 (20130101) B01J 20/3416 (20130101) B01J 20/3441 (20130101) B01J 20/28083 (20130101) B01J 21/18 (20130101) B01J 21/063 (20130101) B01J 23/02 (20130101) B01J 23/04 (20130101) B01J 23/10 (20130101) Original (OR) Class B01J 23/90 (20130101) B01J 35/004 (20130101) B01J 35/0013 (20130101) B01J 35/0046 (20130101) B01J 35/1061 (20130101) B01J 37/08 (20130101) B01J 37/0215 (20130101) B01J 38/00 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/288 (20130101) C02F 2303/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Nuclear Regulatory Commission (NRC)
| US 20210316473 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh-Of The Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jung-Kun Lee (Sewickley Hills, Pennsylvania); Ian Nettleship (Pittsburgh, Pennsylvania); Ryan W. Read (Indiana, Pennsylvania) |
| ABSTRACT | A bonding tape for joining carbide ceramic structures, wherein the bonding tape comprises: a mixture comprising carbide ceramic particles, preceramic polymer liquid, fine carbon particles and metal nanoparticles that form a eutectic liquid at temperatures below 1400° C. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/164474 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/565 (20130101) C04B 35/571 (20130101) C04B 35/632 (20130101) C04B 35/5607 (20130101) C04B 35/5626 (20130101) C04B 37/005 (20130101) C04B 2235/40 (20130101) C04B 2235/80 (20130101) C04B 2235/405 (20130101) C04B 2235/422 (20130101) C04B 2235/483 (20130101) C04B 2235/5454 (20130101) C04B 2235/6025 (20130101) C04B 2237/083 (20130101) C04B 2237/365 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20210320633 | BAGGA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SUNNY BAGGA (CORONA, California); BRIAN J. CADWELL (PASADENA, Maryland); SHAUN MARK GOODWIN (EAST NEW MARKET, Maryland); SCOTT F. ALLWINE (LEESBURG, Virginia) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| INVENTOR(S) | SUNNY BAGGA (CORONA, California); BRIAN J. CADWELL (PASADENA, Maryland); SHAUN MARK GOODWIN (EAST NEW MARKET, Maryland); SCOTT F. ALLWINE (LEESBURG, Virginia) |
| ABSTRACT | A current source circuit can include a first amplifier circuit and a second amplifier circuit. Each of the first and second amplifier circuits can be configured to generate respective amplifier output voltages based on a corresponding input voltage and respective feedback voltage. The current source circuit can further include a cross-coupling circuit that can include a first set of resistors and a second set of resistors. The first set of resistors can be configured to establish a first cross-coupling voltage based on the first amplifier output voltage and the second set of resistors can be configured to establish a second cross-coupling voltage based on the second amplifier output voltage. The first and second amplifier circuits can be configured to maintain the first and second cross-coupling voltage at a given voltage amplitude to provide a constant current at an output node of the current source circuit. |
| FILED | Monday, April 13, 2020 |
| APPL NO | 16/847017 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/28 (20130101) Amplifiers H03F 3/45076 (20130101) Original (OR) Class H03F 2200/372 (20130101) H03F 2203/45101 (20130101) H03F 2203/45134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, October 14, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page