FedInvent™ Patent Applications
Application Details for Thursday, October 21, 2021
This page was updated on Friday, October 22, 2021 at 07:19 PM GMT
Department of Health and Human Services (HHS)
US 20210321594 | Kaczorowski et al. |
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FUNDED BY |
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APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine) |
INVENTOR(S) | Catherine Kaczorowski (Bar Harbor, Maine); Sarah M. Neuner (Bar Harbor, Maine) |
ABSTRACT | Provided herein, in some embodiments, are methods for modulating expression and/or activity of disks large-associated protein 2 (DLGAP2), as well as methods of treating age-related cognitive decline, such as Alzheimer's disease. |
FILED | Friday, April 30, 2021 |
APPL NO | 17/245431 |
CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) Original (OR) Class A01K 2227/105 (20130101) A01K 2267/0312 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210321874 | Wang et al. |
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APPLICANT(S) | California Institute of Technology (Pasadena, California) |
ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
INVENTOR(S) | Lihong Wang (Arcadia, California); Liming Nie (St. Louis, Missouri); Xin Cai (St. Louis, Missouri); Konstantin Maslov (Pasadena, California); Mark A. Anastasio (St. Louis, Missouri); Chao Huang (St. Louis, Missouri); Robert W. Schoonover (St. Louis, Missouri) |
ABSTRACT | Systems and methods of reconstructing photoacoustic imaging data corresponding to a brain of a subject through a skull of a subject utilizing a reconstruction method that incorporates a spatial model of one or more acoustic properties of the brain and skull of the subject derived from an adjunct imaging dataset. |
FILED | Thursday, April 22, 2021 |
APPL NO | 17/302041 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0035 (20130101) A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/0095 (20130101) Original (OR) Class A61B 5/725 (20130101) A61B 5/4839 (20130101) A61B 5/4848 (20130101) A61B 5/7282 (20130101) A61B 6/032 (20130101) A61B 6/501 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 31/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/2418 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210321961 | Harrison et al. |
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APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
ASSIGNEE(S) | Rensselaer Polytechnic Institute (Troy, New York) |
INVENTOR(S) | Daniel David Harrison (Delanson, New York); Ge Wang (Loudonville, New York) |
ABSTRACT | Systems and method for performing X-ray computed tomography (CT) that can improve spectral separation and decrease motion artifacts without increasing radiation dose are provided. The systems and method can be used with either a kVp-switching source or a single-kVp source. When used with a kVp-switching source, an absorption grating and a filter grating can be disposed between the X-ray source and the sample to be imaged. Relative motion of the filter and absorption gratings can by synchronized to the kVp switching frequency of the X-ray source. When used with a single-kVp source, a combination of absorption and filter gratings can be used and can be driven in an oscillation movement that is optimized for a single-kVp X-ray source. With a single-kVp source, the absorption grating can also be omitted and the filter grating can remain stationary. |
FILED | Tuesday, June 22, 2021 |
APPL NO | 17/354286 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/482 (20130101) A61B 6/4007 (20130101) A61B 6/4035 (20130101) Original (OR) Class A61B 6/4085 (20130101) A61B 6/5258 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210321963 | MANOR et al. |
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APPLICANT(S) | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (La Jolla, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Uri MANOR (La Jolla, California); Linjing FANG (La Jolla, California) |
ABSTRACT | A method to, is provided for collecting an image from a sample. The method includes selecting a radiation level for a first probe to meet a desired radiation dosage, and providing, with the first probe, a radiation at a selected point within a region of the sample. The method includes identifying a second selected point within the region of the sample based on a down sampling scheme, and providing a second radiation amount at the second selected point within the region of the sample. The method also includes interpolating a first datum and a second datum based on an up sampling scheme to obtain a plurality of data, and forming an image of the region of the sample with the plurality of data. A system to perform the above method and including the first probe is also provided. |
FILED | Wednesday, August 21, 2019 |
APPL NO | 17/269986 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/542 (20130101) A61B 6/4035 (20130101) A61B 6/4258 (20130101) Original (OR) Class A61B 6/5282 (20130101) A61B 6/5288 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322010 | Roundy et al. |
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APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon) |
INVENTOR(S) | Neil Roundy (Portland, Oregon); Rachel Dreilinger (Lake Oswego, Oregon) |
ABSTRACT | Surgical clips and surgical applicators used in performing rapid tissue closure in either minimally invasive surgeries or traditional open procedures are provided. In one example approach, a surgical clip comprises opposing sides extending from a top portion and terminating at tips positioned below the top portion. The resting position of the clip is its closed position, and in the closed position, the tips are set at a first distance apart. Each side has a cut-out (or hole or aperture) opposite one another. Each cut-out is fully surrounded by the side and does not extend to the top or tips. Each cut-out is configured to engage an inwardly turned hook at the end of a clip array or clip applicator such that the sides bend outwardly away from each other when pressure is applied on the top portion of the clip, thereby placing the clip in an open position. |
FILED | Thursday, July 01, 2021 |
APPL NO | 17/365344 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/083 (20130101) Original (OR) Class A61B 17/128 (20130101) A61B 17/1227 (20130101) A61B 17/1285 (20130101) A61B 2017/0645 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322341 | NICHOLS et al. |
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APPLICANT(S) | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (Baton Rouge, Louisiana) |
ASSIGNEE(S) | |
INVENTOR(S) | Charles D. NICHOLS (New Orleans, Louisiana); Bangning YU (New Orleans, Louisiana) |
ABSTRACT | Activation of 5-HT2A receptors using agonists at surprisingly low concentrations was shown to potently inhibit TNF-α-induced inflammation in multiple cell types. Significantly, proinflammatory markers were also inhibited by the agonist, (R)-DOI, even many hours after treatment with TNF-α. With the exception of a few natural toxins, no current drugs or small molecule therapeutics demonstrate a comparable potency for any physiological effect. TNF-α and TNF-α receptor mediated inflammatory pathways have been strongly implicated in a number of diseases, including atherosclerosis, asthma, rheumatoid arthritis, psoriasis, type II diabetes, depression, schizophrenia, and Alzheimer's disease. Importantly, because (R)-DOI can significantly inhibit the effects of TNF-α many hours after the administration of TNF-α, potential therapies could be aimed not only at preventing inflammation, but also treating inflammatory injury that has already occurred or is ongoing. |
FILED | Tuesday, December 01, 2020 |
APPL NO | 17/108153 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/48 (20130101) A61K 31/138 (20130101) Original (OR) Class A61K 31/397 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322346 | Gu et al. |
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APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York); Chem-Master International Inc. (Albany, New York) |
ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York); Chem-Master International Inc. (East Setauket, New York) |
INVENTOR(S) | Ying Gu (Centereach, New York); Hsi-ming Lee (Setauket, New York); Lorne M. Golub (Smithtown, New York); Francis Johnson (Setauket, New York); Guirong Wang (Syracuse, New York); Osama Abdel-Razek (Syracuse, New York); Yongan Xu (Syracuse, New York) |
ABSTRACT | A method of increasing production of one or more lipoxins in a subject in need thereof comprising administering to the subject an amount of a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, so as to thereby increase production of the one or more lipoxins in the subject. |
FILED | Monday, June 21, 2021 |
APPL NO | 17/353504 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 31/44 (20130101) A61K 31/165 (20130101) Original (OR) Class A61K 31/444 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322355 | Abaffy et al. |
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APPLICANT(S) | Duke University (Durham, North Carolina) |
ASSIGNEE(S) | Duke University (Durham, North Carolina) |
INVENTOR(S) | Tatjana Abaffy (Durham, North Carolina); Hiro Matsunami (Durham, North Carolina) |
ABSTRACT | The present disclosure provides, in part, modulators of prostate-specific G-protein receptor (OR51E2/PSGR) and methods of treating, preventing, and diagnosing prostate cancer using the same. |
FILED | Wednesday, June 23, 2021 |
APPL NO | 17/355898 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/203 (20130101) Original (OR) Class A61K 31/352 (20130101) A61K 31/565 (20130101) A61K 31/568 (20130101) A61K 31/7016 (20130101) A61K 47/06 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322357 | Mohsen |
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APPLICANT(S) | Univeersity of Pittsburgh - Of the Commonwealth System of Higher Eduction (Pittsburgh, Pennsylvania) |
ASSIGNEE(S) | |
INVENTOR(S) | Al-Walid A. Mohsen (Gibsonia, Pennsylvania) |
ABSTRACT | A method of treating medium chain acyl-CoA dehydrogenase deficiency, very long chain acyl-CoA dehydrogenase deficiency, long chain hydroxyacyl-CoA dehydrogenase deficiency, trifunctional protein deficiency, or CPT II deficiency in a patient is provided comprising administering to the patient a therapeutic amount of a triglyceride or other conjugated fatty acid, that bypasses or leads to an intermediate that bypasses the deficient enzyme. Amino acid-conjugated fatty acids also are provided as well as compositions comprising the amino acid-conjugated fatty acids. |
FILED | Thursday, July 11, 2019 |
APPL NO | 17/258877 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/221 (20130101) Original (OR) Class A61K 31/232 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322363 | Brosnan |
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APPLICANT(S) | The Regents of the University of California (Oakland, California) |
ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
INVENTOR(S) | Robert J. Brosnan (Davis, California) |
ABSTRACT | The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods. |
FILED | Monday, November 02, 2020 |
APPL NO | 17/087365 |
CURRENT CPC | Veterinary Instruments, Implements, Tools, or Methods A61D 7/04 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 31/02 (20130101) A61K 31/08 (20130101) A61K 31/025 (20130101) A61K 31/045 (20130101) A61K 31/341 (20130101) A61K 31/351 (20130101) Original (OR) Class A61K 31/357 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/01 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322383 | AIZENMAN et al. |
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APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
ASSIGNEE(S) | |
INVENTOR(S) | Elias AIZENMAN (Pittsburgh, Pennsylvania); Carlos Jaime CAMACHO (Pittsburgh, Pennsylvania) |
ABSTRACT | Disclosed herein are small molecule compounds capable of disrupting Kv2.1-syntaxin binding. The compounds are useful for treating a variety of neurological disorders, diseases, and injuries. |
FILED | Wednesday, July 31, 2019 |
APPL NO | 17/264982 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) A61K 31/428 (20130101) A61K 31/506 (20130101) A61K 31/4155 (20130101) Original (OR) Class A61K 31/4178 (20130101) A61K 31/4409 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322396 | Kohane et al. |
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APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
INVENTOR(S) | Daniel S. Kohane (Newton, Massachusetts); Rong Yang (Cambridge, Massachusetts) |
ABSTRACT | The present disclosure provides compositions and methods for delivery of therapeutic agents across a barrier. The compositions include a therapeutic agent (e.g., antimicrobial agent, antibiotic, or anesthetic agent), a permeation enhancer which increases the flux of the therapeutic agent across the barrier, and a matrix forming agent, wherein the composition comprises between about 0.5-5.0% wt/vol of a permeation enhancer that is sodium dodecyl sulfate; wherein the compositions comprise between about 0.5-2.5% wt/vol of a permeation enhancer that is bupivacaine; wherein the compositions comprise between about 1.5-12.0% wt/vol of a permeation enhancer that is limonene; and wherein the compositions comprise between about 9.0-19.0% wt/vol of a polymer that is poloxamer 407-poly(butoxy)phosphoester; and optionally further comprises between about 0.01-0.50% wt/vol of another therapeutic agent that is a sodium channel blocker anesthetic agent (e.g., tetrodotoxin). |
FILED | Friday, August 30, 2019 |
APPL NO | 17/272212 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0046 (20130101) A61K 31/445 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/529 (20130101) A61K 31/573 (20130101) A61K 45/06 (20130101) A61K 47/06 (20130101) A61K 47/20 (20130101) A61K 47/34 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0021 (20130101) A61M 31/00 (20130101) A61M 2210/0662 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322398 | Tang et al. |
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APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
ASSIGNEE(S) | |
INVENTOR(S) | Weiping Tang (Middleton, Wisconsin); Ka Yang (Madison, Wisconsin); Hao Wu (Madison, Wisconsin) |
ABSTRACT | Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; methods of using the composition to inhibit neoplastic cell growth in mammals, including humans. |
FILED | Monday, June 28, 2021 |
APPL NO | 17/359857 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4439 (20130101) Original (OR) Class Heterocyclic Compounds C07D 401/14 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322405 | Ding et al. |
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APPLICANT(S) | Washington University (St. Louis, Missouri); The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts); Battelle Memorial Institute (Richland, Washington) |
ASSIGNEE(S) | |
INVENTOR(S) | Li Ding (St. Louis, Missouri); Song Cao (St. Louis, Missouri); Yige Wu (St. Louis, Missouri); Alla Karpova (St. Louis, Missouri); Liang-Bo Wang (St. Louis, Missouri); Milan Chheda (St. Louis, Missouri); Feng Chen (St. Louis, Missouri); Ramaswamy Govindan (St. Louis, Missouri); Albert Kim (St. Louis, Missouri); Michael Gillette (Boston, Massachusetts); Steven Carr (02142, Massachusetts); Shankha Satpathy (Cambridge, Massachusetts); Tao Liu (Richland, Washington); Karin D. Rodland (Richland, Washington); Richard D. Smith (Richland, Washington) |
ABSTRACT | The present disclosure provides for compositions and methods of treating cancer. In some embodiments, PTPN11 is targeted with and anti-PTPN11 drug, such as a Shp2 inhibitor (e.g., SHP099). In some embodiments, other upregulated, hyperphosphorylated, or hyperacetylated target proteins are inhibited or targeted. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/231273 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/497 (20130101) Original (OR) Class A61K 31/685 (20130101) A61K 31/702 (20130101) A61K 31/4985 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322414 | Smith et al. |
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APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Lois Smith (West Newton, Massachusetts); Jean-Sebastien Joyal (Boston, Massachusetts) |
ABSTRACT | The instant invention provides methods and compositions related to discovery of Free Fatty Acid Receptor 1 (FFA1) as a therapeutic target for treatment or prevention of diseases or disorders of neurons that are characterized by angiogenesis, or of vascular diseases of the eye, retinal degeneration and/or tumors more generally. Therapeutic and/or prophylactic uses and compositions of known FFA1 inhibitors, including small molecules and nucleic acid agents, are described. Methods for identification of novel FFA1 inhibitors are also provided. |
FILED | Friday, February 17, 2017 |
APPL NO | 15/999535 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/513 (20130101) Original (OR) Class A61K 31/519 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) G01N 2800/50 (20130101) G01N 2800/164 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322415 | BARRY et al. |
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APPLICANT(S) | ASTRAZENE CA AB (Sodertalje, Sweden); THE UNITED STATES OF AMERICA, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
ASSIGNEE(S) | ASTRAZENECA AB (Södertälje, Sweden); THE UNITED STATES OF AMERICA, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
INVENTOR(S) | Simon BARRY (Cambridge, United Kingdom); Jane KENDREW (Cheshire, United Kingdom); Tony HO (Gaithersburg, Maryland); Stephen Robert WEDGE (Cambridge, United Kingdom); Susan Percy IVY (Bethesda, Maryland); Elise KOHN (Bethesda, Maryland); Jung-Min LEE (National Institutes of Health, Maryland) |
ABSTRACT | Methods comprising repeating cycles of administration of a composition comprising cediranib according to a fixed intermittent dosing regimen comprising administration of an effective amount of the composition comprising cediranib on one or more consecutive days of a cycle followed by one or more consecutive days of rest on which said composition is not administered are disclosed herein, and may be used as monotherapy or may comprise administration of one or more partner drugs or therapies and may be used in combination therapy. Such methods may produce an antiangiogenic and/or vascular permeability reducing effect, treat at least one disease state associated with angiogenesis, reduce the total dose of cediranib required to provide effective VEGF inhibition, reduce adverse events and toxicity due to cediranib administration, maintain cover on the VEGF pathway despite reduction of total doses of cediranib, and/or increase repair of healthy, non-cancerous tissue during treatment of cancer using combination therapies. |
FILED | Tuesday, February 14, 2017 |
APPL NO | 16/077720 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/502 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 39/39558 (20130101) A61K 45/06 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322416 | Wang et al. |
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FUNDED BY |
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APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota); Emory University (Atlanta, Georgia) |
ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
INVENTOR(S) | Zhengqiang Wang (Minneapolis, Minnesota); Stefanos G. Sarafianos (Atlanta, Georgia) |
ABSTRACT | The invention provides a compound of formula I, formula II, or formula III: or a salt thereof, wherein R1-R10 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as HIV-1 CA-targeting molecules and as antiviral agents. |
FILED | Monday, April 05, 2021 |
APPL NO | 17/222433 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/405 (20130101) A61K 31/495 (20130101) A61K 31/513 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 31/4178 (20130101) A61K 31/4184 (20130101) A61K 31/4439 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Acyclic or Carbocyclic Compounds C07C 233/88 (20130101) Heterocyclic Compounds C07D 209/34 (20130101) C07D 235/02 (20130101) C07D 239/54 (20130101) C07D 239/96 (20130101) C07D 241/08 (20130101) C07D 401/12 (20130101) C07D 403/12 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322425 | Gendelman et al. |
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APPLICANT(S) | Board of Regents of the University of Nebraska (Lincoln, Nebraska) |
ASSIGNEE(S) | |
INVENTOR(S) | Howard Gendelman (Omaha, Nebraska); Benson Edagwa (Omaha, Nebraska) |
ABSTRACT | The present invention provides prodrugs and methods of use thereof. |
FILED | Monday, May 24, 2021 |
APPL NO | 17/303229 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1641 (20130101) A61K 31/5365 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322427 | LEE et al. |
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APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
ASSIGNEE(S) | |
INVENTOR(S) | Seulki LEE (Ellicott City, Maryland); Han Seok KO (Lutherville, Maryland); Ted M. DAWSON (Baltimore, Maryland); Martin G. POMPER (Baltimore, Maryland); Donghoon KIM (Seoul, South Korea); Yumin OH (Elkridge, Maryland); Seung-Hwan KWON (Ellicott City, Maryland); Yong Joo PARK (Suwon-si, Gyeonggi-do, South Korea) |
ABSTRACT | Provided herein are compositions comprising a RIPK2 inhibitor and methods of using the RIPK2 inhibitor for treating or preventing neurodegenerative diseases or disorders. Also provided herein are methods of screening or identifying therapeutic agents useful for treating or preventing neurodegenerative diseases or disorders. |
FILED | Friday, August 30, 2019 |
APPL NO | 17/271966 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/504 (20130101) A61K 31/519 (20130101) A61K 31/529 (20130101) A61K 31/4439 (20130101) A61K 31/4709 (20130101) A61K 31/5025 (20130101) A61K 31/5377 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322441 | Serhan et al. |
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FUNDED BY |
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APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Charles N. Serhan (Needham, Massachusetts); Jesmond P. Dalli (Brookline, Massachusetts); Nan Chiang (Somerville, Massachusetts) |
ABSTRACT | A family of bioactive compounds identified in self-resolving inflammatory exudates is disclosed. The compounds give UV chromophores characteristic of a conjugated triene double bond system coupled to an auxochrome allylic to the triene. Further elucidation of the compounds reveals that they have a resolvin backbone conjugated to a peptide or amino acid moiety via an auxochrome. In some embodiments the auxochrome is sulfur. However, the auxochrome may be NH, CH2 or O. The compounds have potent bioactivity, in vitro, and, in vivo, including promoting resolution of infection, stimulating macrophage phagocytosis of bacteria; protecting tissues from neutrophil mediated damage, promoting tissue repair and regeneration and preventing or limiting second organ reflow/reperfusion damage. |
FILED | Tuesday, June 15, 2021 |
APPL NO | 17/347842 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/557 (20130101) Original (OR) Class A61K 47/64 (20170801) A61K 47/542 (20170801) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322451 | ALBERINI et al. |
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FUNDED BY |
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APPLICANT(S) | New York University (New York, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Cristina Maria ALBERINI (New York, New York); Dirk TRAUNER (New York, New York); Christopher James ARP (The Woodlands, Texas) |
ABSTRACT | Provided are compositions and methods for memory enhancement, including recovery of memory impairment. The compositions and methods relate to mannose-6-phosphate and derivatives of mannose-6-phosphate. The methods relate to administration of M6P or derivatives thereof to individuals in whom memory enhancement is desired. |
FILED | Monday, August 12, 2019 |
APPL NO | 17/267721 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7028 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322454 | Martin |
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FUNDED BY |
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APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
ASSIGNEE(S) | |
INVENTOR(S) | James F. Martin (Houston, Texas) |
ABSTRACT | Embodiments of the disclosure encompass methods and compositions related to modulating the Hippo pathway to inhibit fibrosis and/or inflammation in a tissue and/or organ of an individual in need thereof. In specific embodiments, the disclosure concerns modulation of LATS1, LATS2, or both, such as providing to the individual an effective amount of one or more agents that increase the levels of LATS1, LATS2, or both in the individual. In specific cases, cardiac fibrosis is treated with effective levels of vector(s) comprising LATS1, LATS2, or both. |
FILED | Tuesday, April 23, 2019 |
APPL NO | 17/049891 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322455 | Blazar et al. |
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FUNDED BY |
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APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); New York University (New York, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Bruce R. Blazar (Golden Valley, Minnesota); Cameron McDonald-Hyman (St. Paul, Minnesota); Michael Dustin (New York, New York); Sudha Kumari (New York, New York); Tom Neubert (New York, New York); James Muller (New York, New York); Keli Hippen (Minneapolis, Minnesota) |
ABSTRACT | Methods and compositions for increasing the suppressive function of regulatory T-cells (Tregs) are provided. |
FILED | Friday, April 23, 2021 |
APPL NO | 17/238773 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Original (OR) Class A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 15/1137 (20130101) C12N 15/1138 (20130101) C12N 2310/14 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322456 | Juliano et al. |
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FUNDED BY |
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APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Rudolph L. Juliano (Chapel Hill, North Carolina); Silvia M. Kreda (Mebane, North Carolina); Ling Wang (Chapel Hill, North Carolina); Xin Ming (Chapel Hill, North Carolina); Lindsey Ingerman James (Chapel Hill, North Carolina); Ranathunga Arachchillage Yamuna Kumari Ariyarathna (Carrboro, North Carolina) |
ABSTRACT | This disclosure is directed to methods, compounds and compositions for delivering nucleic acids to a cell of interest. In particular, it provides salts that are particularly effective in delivering nucleic acids to cells in the lung for disorders such as cystic fibrosis (CF). |
FILED | Monday, June 21, 2021 |
APPL NO | 17/352716 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4184 (20130101) A61K 31/4985 (20130101) A61K 31/7125 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Heterocyclic Compounds C07D 235/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/314 (20130101) C12N 2310/3233 (20130101) C12N 2320/31 (20130101) C12N 2320/33 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322457 | Jain et al. |
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FUNDED BY |
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APPLICANT(S) | Advaite LLC. (Chicago, Illinois) |
ASSIGNEE(S) | Advaite LLC. (Chicago, Illinois) |
INVENTOR(S) | Sandeep Jain (Oak Park, Illinois); Karthik Musunuri (Chester Springs, Pennsylvania) |
ABSTRACT | The present invention provides an ophthalmic formulation consisting essentially of one or more pharmaceutically acceptable excipients; a pharmaceutically active compound that is capable of reducing the amount of inflammatory neutrophil product on the ocular surface; and optionally a second pharmaceutically active compound selected from the group consisting of a steroid, an anti-inflammatory agent, a mucolytic agent and a combination thereof. In particular, the present invention provides an ophthalmic formulation where the pharmaceutically active compound is capable of treating a clinical condition selected from the group consisting of inflammatory and immunological ocular surface disease that can cause symptoms of ocular discomfort, mucocellular aggregates/debris in tear film, symblepheron formation, fornix foreshortening, eyelid margin/conjunctival keratinization, corneal neovascularization/pannus, subconjunctival fibrosis, and herpetic eye disease. The present invention also provides a method for diagnosing or monitoring an ocular surface disease. |
FILED | Monday, June 28, 2021 |
APPL NO | 17/361310 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322462 | NEWMAN et al. |
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FUNDED BY |
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APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Dianne K. NEWMAN (Pasadena, California); Melanie A. SPERO (Pasadena, California); Manuela MARTINS-GREEN (Riverside, California); John D. COATES (Walnut Creek, California) |
ABSTRACT | Wound healing matrices, compounds, compositions, methods and systems comprising one or more chlorates, one or more chlorites, one or more antibiotics, one or more other antimicrobials, and/or one or more wound healing agents. |
FILED | Monday, April 19, 2021 |
APPL NO | 17/234656 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0014 (20130101) A61K 31/43 (20130101) A61K 31/198 (20130101) A61K 31/355 (20130101) A61K 31/424 (20130101) A61K 31/427 (20130101) A61K 31/431 (20130101) A61K 31/496 (20130101) A61K 31/545 (20130101) A61K 31/546 (20130101) A61K 31/4164 (20130101) A61K 31/7036 (20130101) A61K 31/7056 (20130101) A61K 33/00 (20130101) Original (OR) Class A61K 33/14 (20130101) A61K 33/18 (20130101) A61K 38/1808 (20130101) A61K 38/1841 (20130101) A61K 38/1858 (20130101) A61K 38/1866 (20130101) A61K 38/4886 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) A61P 31/02 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322472 | Medin et al. |
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FUNDED BY |
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APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
ASSIGNEE(S) | |
INVENTOR(S) | Jeffrey A. Medin (Shorewood, Wisconsin); Daniel H. Fowler (Milwaukee, Wisconsin); Murtaza S. Nagree (Milwaukee, Wisconsin); Tania Felizardo (Milwaukee, Wisconsin) |
ABSTRACT | The present disclosure provides methods of treating lysosomal storage disorders. The method comprises producing vector-transduced T-Rapa cells that express a transgene of interest and administering the cells to a patient in need thereof. |
FILED | Monday, April 29, 2019 |
APPL NO | 17/050949 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/47 (20130101) A61K 38/443 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/86 (20130101) Enzymes C12Y 101/01205 (20130101) C12Y 302/01022 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322484 | SUSSMAN et al. |
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FUNDED BY |
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APPLICANT(S) | SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION, DBA SAN DIEGO STATE UNIVERSITY RESE (San Diego, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Mark A. SUSSMAN (San Diego, California); Megan M. MONSANTO (San Diego, California) |
ABSTRACT | In alternative embodiments, provided are macrocellular structures or artificially configured plurality of cells, the so-called “cardioclusters” as provided herein, comprising: a core region or cluster: comprising a plurality of first cardiac stem cells or cardiac progenitor cells; and a second region or a peripheral region positioned at least partially surrounding the outer surface of the core region or cluster, or at least partially around the core region or cluster, comprising a plurality of second cardiac stem cells; and methods for making and using them. In alternative embodiments, the second cardiac progenitor cells are cardiac progenitor cells or cardiac stem cells, mesenchymal stem cells or mesenchymal progenitor cells, or endothelial progenitor cells or endothelial stem cells. |
FILED | Tuesday, June 15, 2021 |
APPL NO | 17/348038 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/34 (20130101) Original (OR) Class A61K 35/44 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 2502/28 (20130101) C12N 2502/1352 (20130101) C12N 2513/00 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322507 | Langer et al. |
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FUNDED BY |
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APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
INVENTOR(S) | Robert S. Langer (Newton, Massachusetts); Carlo Giovanni Traverso (Newton, Massachusetts); Ameya R. Kirtane (Somerville, Massachusetts); Daniel Cahill (Winchester, Massachusetts); Ganesh Shankar (Brookline, Massachusetts) |
ABSTRACT | Provided herein are pharmaceutical compositions for local administration of metabolic inhibitors, methods of locally administering such compositions, and rapid diagnostic methods for identifying mutant allele during the course of a surgical procedure. |
FILED | Wednesday, June 30, 2021 |
APPL NO | 17/363897 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/51 (20130101) A61K 38/005 (20130101) Original (OR) Class A61K 47/6937 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 9/1077 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6858 (20130101) C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 101/01041 (20130101) C12Y 204/02012 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322510 | MENDELOWITZ et al. |
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FUNDED BY |
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APPLICANT(S) | THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia) |
ASSIGNEE(S) | |
INVENTOR(S) | David MENDELOWITZ (Vienna, Virginia); Vivek JAIN (McLean, Virginia); Heather JAMESON (Lynnfield, Massachusetts); Jay Shawn KIMBRO (Stevensville, Maryland) |
ABSTRACT | The present disclosure provides methods for treating obstructive sleep apnea (OSA) and OSA induced cardiorespiratory diseases. The disclosure provides, inter alia, methods for treating or alleviating: OSA or OSA induced hypertension, cardiac arrhythmias, myocardial ischemia, sudden cardiac death or stroke, by administering oxytocin. The disclosure further provides methods for improving sleep satisfaction in OSA patients by administering oxytocin. |
FILED | Wednesday, November 18, 2020 |
APPL NO | 16/951048 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 38/095 (20190101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322512 | Marshall |
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FUNDED BY |
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APPLICANT(S) | CALDER BIOSCIENCES INC. (New York, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Christopher Patrick Marshall (New York, New York) |
ABSTRACT | The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine. |
FILED | Monday, November 30, 2020 |
APPL NO | 17/107067 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/162 (20130101) Original (OR) Class Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/16051 (20130101) C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56988 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322522 | SUSSMAN et al. |
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FUNDED BY |
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APPLICANT(S) | SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION (San Diego, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Mark A SUSSMAN (San Diego, California); John A. MURASKI (San Clemente, California) |
ABSTRACT | The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding the serine/threonine kinase PIM-1, and methods for making and using them; including methods for inducing cellular proliferation, and protecting cardiac cells from hypoxia and cellular apoptosis. The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding PIM-1, and methods for enhancing the regenerative potential of stem cells in the heart. |
FILED | Wednesday, March 31, 2021 |
APPL NO | 17/219749 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 38/45 (20130101) Original (OR) Class A61K 2035/124 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 15/86 (20130101) Enzymes C12Y 207/11 (20130101) C12Y 207/12 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322524 | Qi |
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FUNDED BY |
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APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
ASSIGNEE(S) | |
INVENTOR(S) | Xin Qi (Cleveland, Ohio) |
ABSTRACT | A method of inhibiting aberrant ATAD3A activation and/or oligomerization in mitochondria of a cell includes administering to the cell a therapeutic agent that inhibits binding or complexing of ATAD3A with Drp1 in the mitochondria of the cell. |
FILED | Wednesday, July 31, 2019 |
APPL NO | 17/264923 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/46 (20130101) Original (OR) Class A61K 38/162 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322536 | Compans et al. |
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FUNDED BY |
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APPLICANT(S) | Emory University (Atlanta, Georgia) |
ASSIGNEE(S) | |
INVENTOR(S) | Richard Compans (Atlanta, Georgia); Elena Vassilieva (Roswell, Georgia) |
ABSTRACT | This disclosure relates to boosting the immunogenicity of vaccines using an adjuvant combination comprising a saponin and an agonist of the intracellular stimulator of interferon genes pathway. In certain embodiments, the vaccine comprises an inactivated virus, attenuated virus, virus protein, virus like particle, or virosome. In certain embodiments, the human subject is of advanced age or elderly. In certain embodiments, the viral vaccine is an influenza vaccine. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/233333 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/55577 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322548 | YUNG et al. |
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FUNDED BY |
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APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
ASSIGNEE(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
INVENTOR(S) | Lai-Ming YUNG (Jamison, Pennsylvania); Paul B. YU (Boston, Massachusetts) |
ABSTRACT | The technology described herein is directed to methods and compositions for the treatment of hypertension, e.g. pulmonary arterial hypertension, relating to inhibition of TGFβ1, TGFβ3, and/or GDF-15. |
FILED | Monday, April 26, 2021 |
APPL NO | 17/239983 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 16/22 (20130101) C07K 2319/30 (20130101) C07K 2319/32 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322557 | Burdick et al. |
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FUNDED BY |
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APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
ASSIGNEE(S) | |
INVENTOR(S) | Jason Alan Burdick (Philadelphia, Pennsylvania); Sujata Sahoo (Wilmington, Delaware); Cindy Chung (Parsippany, New Jersey) |
ABSTRACT | Provided are polysaccharide compositions capable of controllable hydrolytic degradation and suitable for controlled release of therapeutic agents. Also provided are methods for synthesizing such compositions and a variety of applications in which the compositions may be used. |
FILED | Wednesday, June 23, 2021 |
APPL NO | 17/355660 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/36 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/3834 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) A61L 2300/442 (20130101) A61L 2300/604 (20130101) A61L 2430/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 5/0663 (20130101) C12N 2533/40 (20130101) C12N 2533/80 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322559 | Kessler et al. |
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FUNDED BY |
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APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
ASSIGNEE(S) | |
INVENTOR(S) | Julian Kessler (Salt Lake City, Utah); Michael S. Yu (Salt Lake City, Utah); Yang Li (Salt Lake City, Utah) |
ABSTRACT | Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a dimeric collagen hybridizing peptide comprising a first and second collagen hybridizing peptide, a linker; and a branch point, wherein the first and second collagen hybridizing peptides comprise the sequence of at least (GXY)n, wherein G is glycine, wherein X and Y are any amino acid, and wherein n is any number between 3 and 12. Also disclosed are methods of detecting denatured collagen in a sample comprising contacting a composition comprising any one of the disclosed peptide conjugates to a sample, wherein the active agent comprises a therapeutic agent, and detecting the presence or absence of binding of the peptide conjugate to denatured collagen, the presence of binding indicating the presence of denatured collagen in the sample. Also disclosed are methods of treating a disease or injury involving collagen damage comprising administering to a subject having a disease or injury involving collagen damage any one of the disclosed peptide conjugates. |
FILED | Wednesday, February 24, 2021 |
APPL NO | 17/184289 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) A61K 47/65 (20170801) A61K 47/641 (20170801) Original (OR) Class Peptides C07K 14/78 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6887 (20130101) G01N 2333/78 (20130101) G01N 2500/20 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322569 | BUCHMAN et al. |
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FUNDED BY |
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APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); THE UNIVERSITY OF KANSAS (Lawrence, Kansas) |
ASSIGNEE(S) | |
INVENTOR(S) | Steven R. BUCHMAN (Ann Arbor, Michigan); Mark COHEN (Ann Arbor, Michigan); Alexis DONNEYS (Ann Arbor, Michigan); Noah NELSON (Ann Arbor, Michigan); Laird FORREST (Lawrence, Kansas); Ti ZHANG (Lawrence, Kansas); Qiuhong YANG (Lawrence, Kansas) |
ABSTRACT | The present invention relates to novel therapeutic nanoparticles. In particular, the present invention is directed to nanoparticles associated (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) with angiogenesis-activating-agents, methods of synthesizing the same, devices or compositions comprising such nanoparticles, as well as systems and methods utilizing the nanoparticles (e.g., in therapeutic settings for enhancing and/or activating angiogenesis at targeted tissue region). |
FILED | Tuesday, June 22, 2021 |
APPL NO | 17/354514 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5169 (20130101) A61K 31/16 (20130101) A61K 47/61 (20170801) A61K 47/6939 (20170801) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/50 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 2300/412 (20130101) A61L 2300/624 (20130101) A61L 2300/626 (20130101) A61L 2400/12 (20130101) A61L 2430/02 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/00 (20180101) A61P 19/08 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322622 | Miller et al. |
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FUNDED BY |
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APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
ASSIGNEE(S) | |
INVENTOR(S) | Lloyd S. Miller (Ellicott City, Maryland); Hai-Quan Mao (Baltimore, Maryland); Alyssa Ashbaugh (Baltimore, Maryland); Xuesong Jiang (Lutherville-Timonium, Maryland); Jesse Zheng (Johns Creek, Georgia); Sashank Reddy (Baltimore, Maryland); Bart Kachniarz (Baltimore, Maryland) |
ABSTRACT | The presently disclosed subject matter provides a composite film which allows for the co-delivery of two or more bioactive agents with independent control of loading level and release profile for each bioactive agent, bandages and/or medical devices coated with the composite film, methods for preparing the composite film, and use of the composite film for treating infections or preventing biofilm formation in a subject. |
FILED | Friday, August 16, 2019 |
APPL NO | 17/267714 |
CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/26 (20130101) A61L 15/44 (20130101) Original (OR) Class A61L 15/46 (20130101) A61L 15/425 (20130101) A61L 2300/406 (20130101) A61L 2400/12 (20130101) A61L 2420/02 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 7/02 (20130101) C08K 2201/011 (20130101) Compositions of Macromolecular Compounds C08L 67/04 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322632 | Bertassoni et al. |
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FUNDED BY |
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APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
ASSIGNEE(S) | |
INVENTOR(S) | Luiz E. Bertassoni (Portland, Oregon); Avathamsa Athirasala (Portland, Oregon); Anthony Tahayeri (Sherwood, Oregon) |
ABSTRACT | A modular synthetic tissue-graft scaffold (10) includes one or more nominally identical scaffold cages (12) configured to facilitate regrowth of tissue of an organism in and around the scaffold cages. Each scaffold cage comprises a volumetric enclosure (18) bounded by a perforated wall structure (40). A recess (24) formed at one end of the volumetric enclosure defines an inner stepped coupling surface. An annular raised portion (26) positioned at the other end of the volumetric enclosure forms an outwardly projecting stepped seating surface sized to form a complementary matable surface to the inner stepped coupling surface for whenever an inner stepped coupling surface of another one of the cages is placed on the outer stepped seating surface of the scaffold cage. Corridors (46) extending through the perforated wall structure and communicating with passageways (54) within the volumetric enclosure enable migration of material within and out of the scaffold cage. |
FILED | Friday, July 26, 2019 |
APPL NO | 17/263873 |
CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/12 (20130101) Original (OR) Class A61L 27/52 (20130101) A61L 27/105 (20130101) A61L 2430/02 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/124 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/10 (20200101) B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0691 (20130101) C12N 2501/135 (20130101) C12N 2501/155 (20130101) C12N 2501/165 (20130101) C12N 2513/00 (20130101) C12N 2533/14 (20130101) C12N 2533/18 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322647 | Dumont et al. |
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FUNDED BY |
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APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
ASSIGNEE(S) | |
INVENTOR(S) | Courtney M. Dumont (Ypsilanti, Michigan); Mitchell A. Carlson (Ann Arbor, Michigan); Lonnie D. Shea (Ann Arbor, Michigan) |
ABSTRACT | Biomaterial implants and methods for facilitating tissue repair and regeneration are provided herein. The implants may include organized hydrogel structures. Such implants are fabricated using a 2-phase polymerization technique, wherein hydrogel-based microspheres are formed as an intermediate product of the 2-phase polymerization technique. The implants of various embodiments provide an aligned substrate to guide tissue regeneration and can be cut or formed to conform to the size and shape of an injury. |
FILED | Friday, April 26, 2019 |
APPL NO | 17/050876 |
CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/52 (20130101) Original (OR) Class A61L 27/56 (20130101) A61L 2430/32 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322648 | Rivnay et al. |
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FUNDED BY |
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APPLICANT(S) | Northwestern University (Evanston, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Jonathan Rivnay (Chicago, Illinois); Anthony J. Petty (Evanston, Illinois); Cheng Sun (Wilmette, Illinois); Henry Oliver T. Ware (Evanston, Illinois) |
ABSTRACT | Biocompatible polymer hydrogel composite structures, methods of making the composite structures, and methods of using the composite structures as scaffolds for biological tissue growth and regeneration are provided. The methods for making the composite structures start with a porous high resolution three-dimensional hydrogel scaffold in which polymer precursors are infused and then polymerized in situ to form a water-soluble, electrically conducting polymer that is bonded to and/or entrapped within the hydrogel. |
FILED | Wednesday, April 14, 2021 |
APPL NO | 17/230195 |
CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/44 (20130101) A61L 27/52 (20130101) Original (OR) Class A61L 27/56 (20130101) A61L 27/3695 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 20/20 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322652 | PURCELL et al. |
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FUNDED BY |
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APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
ASSIGNEE(S) | |
INVENTOR(S) | Brendan Patrick PURCELL (Brooklyn, New York); Jason Alan BURDICK (Philadelphia, Pennsylvania); Leo L. WANG (Philadelphia, Pennsylvania) |
ABSTRACT | The invention concerns methods of delivering a hydrogel to the heart, comprising: introducing a hydrogel composition into a subject, said hydrogel comprising components mixed prior to introduction; the introducing being performed such that the hydrogel composition resides between the epicardium and the pericardium of the subject. In some embodiments, the injection is performed using a syringe or catheter. |
FILED | Friday, August 30, 2019 |
APPL NO | 17/271778 |
CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/16 (20130101) Original (OR) Class A61L 31/18 (20130101) A61L 31/042 (20130101) A61L 31/145 (20130101) A61L 2300/80 (20130101) A61L 2300/232 (20130101) A61L 2300/424 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322668 | Oberstar et al. |
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FUNDED BY |
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APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
ASSIGNEE(S) | |
INVENTOR(S) | Erick Louis Oberstar (Verona, Wisconsin); Michael Antonio Speidel (Madison, Wisconsin) |
ABSTRACT | Aspects of the disclosure are directed to methods and/or apparatuses involving modifying flow and/or concentration of an agent being injected for characterizing a vascular system. As may be implemented in accordance with one or more embodiments, a liquid including an agent is injected into a vascular system, by dynamically modulating a flow rate of the agent being injected over a range of flow rates. The vascular system is characterized based on a response of the vascular system to the dynamic modulation. In some implementations, such an approach involves using an injector that operates to separately control the rate at which an agent and other liquid such as saline are injected. These approaches can be implemented with modulation schemes using one or more of a variety of functions. |
FILED | Wednesday, August 07, 2019 |
APPL NO | 16/534725 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0263 (20130101) A61B 6/481 (20130101) A61B 6/507 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/007 (20130101) Original (OR) Class A61M 5/1408 (20130101) A61M 5/1452 (20130101) A61M 2205/3334 (20130101) A61M 2230/04 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322771 | Wagner et al. |
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FUNDED BY |
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APPLICANT(S) | Highland Instruments, Inc. (Somerville, Massachusetts) |
ASSIGNEE(S) | Highland Instruments, Inc. (Somerville, Massachusetts) |
INVENTOR(S) | Timothy Andrew Wagner (Somerville, Massachusetts); Uri Tzvi Eden (Somerville, Massachusetts) |
ABSTRACT | The invention generally relates to methods of stimulating tissue based upon filtering properties of the tissue. In certain aspects, the invention provides methods for stimulating tissue that involve analyzing at least one filtering property of a region of at least one tissue, and providing a dose of energy to the at least one region of tissue based upon results of the analyzing step. |
FILED | Monday, April 19, 2021 |
APPL NO | 17/233762 |
CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 23/0236 (20130101) A61H 23/0245 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36025 (20130101) Original (OR) Class A61N 1/36082 (20130101) A61N 5/02 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322775 | Grill et al. |
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FUNDED BY |
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APPLICANT(S) | Duke University (Durham, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Warren M. Grill (Durham, North Carolina); Isaac Cassar (Durham, North Carolina); Nathan Titus (Durham, North Carolina) |
ABSTRACT | Systems and methods for determining optimal temporal patterns of neural stimulation are disclosed. According to an aspect, a method includes selecting a temporal pattern for neural stimulation. The method also includes determining a mutation type for altering a pattern of pulses of the temporal pattern. The method also includes identifying a location within the pattern of pulses of the temporal pattern to alter based on the determined mutation type. The method further includes altering the pattern of pulses of the temporal pattern based on the identified location and mutation type for application of the altered temporal pattern to a subject. |
FILED | Tuesday, June 22, 2021 |
APPL NO | 17/355092 |
CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/36139 (20130101) A61N 1/36178 (20130101) Original (OR) Class A61N 1/36185 (20130101) A61N 1/37235 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 50/50 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322788 | Liu et al. |
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FUNDED BY |
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APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
ASSIGNEE(S) | |
INVENTOR(S) | Wei Liu (Scottsdale, Arizona); Jie Shan (Scottsdale, Arizona) |
ABSTRACT | Robust optimization systems and methods are provided for intensity modulated proton therapy (IMPT) that may be deployed in a clinically practical way to enable users to control the balance between nominal plan quality and plan robustness in a user-defined way. The method may include a normalized dose interval volume histogram (NDIVH)-based robust optimization, where the normalized dose interval (NDI) is calculated for each voxel considering dose variations in the face of uncertainties. It is then used to create a NDIVH. The area under this NDIVH curve may then be used to quantify plan robustness. By using normalized dose interval volume constraints (NDIVC) to control the shape of the NDIVH curves, plan robustness may be adjusted. The tradeoff between nominal plan quality and plan robustness can be modified in a user-defined way by adjusting positions of the NDIVCs on the NDIVH curves. |
FILED | Wednesday, August 28, 2019 |
APPL NO | 17/271751 |
CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1031 (20130101) Original (OR) Class A61N 2005/1087 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322796 | Hubbard et al. |
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FUNDED BY |
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APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Devin Kerry Hubbard (Chapel Hill, North Carolina); Nicole Lewis Wiley (Pittsboro, North Carolina); Ethan John Smith (Garner, North Carolina) |
ABSTRACT | Face mask devices, systems, and methods of use include a frame that holds a suitable filter material, including a face mask, over the user's face to form a seal and prevent unfiltered air from being inhaled through the nose or mouth of the user without first passing through the filter material. The frame is removably attached over the users face by, for example, adjustable straps. The frame may be adjustable in size to be suitable for use on user's having different facial sizes, shapes, and/or geometries. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/232596 |
CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/1161 (20130101) Devices, Apparatus or Methods for Life-saving A62B 7/10 (20130101) Original (OR) Class A62B 18/02 (20130101) A62B 18/082 (20130101) A62B 18/084 (20130101) A62B 23/025 (20130101) Separation B01D 39/16 (20130101) B01D 39/083 (20130101) B01D 46/0005 (20130101) B01D 2239/0622 (20130101) B01D 2239/0627 (20130101) B01D 2279/65 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322976 | NG Pitti et al. |
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FUNDED BY |
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APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Carlos Francisco NG Pitti (Jamaica Plain, Massachusetts); Ulri Nicole Lee (Seattle, Washington); Richard Novack (Boston, Massachusetts); Olivier Yves Frederic Henry (Brookline, Massachusetts); Remco Franciscus Peter Van Erp (Sint Anthonis, Netherlands); Donald E. Ingber (Boston, Massachusetts) |
ABSTRACT | A fluidic device includes a fluidic layer, a capture material, and an electronics layer, the fluidic layer includes a main channel and a pair of sample channels fluidly coupled to the main channel. The pair of sample channels is configured to receive and introduce a sample material into the device. The sample material includes an analyte. The capture material is positioned in a portion of the main channel that is spaced from the pair of sample channels. The capture material has a three-dimensional matrix of receptors therein configured to bond with the analyte. The capture material has a length that is associated with a dynamic range of the fluidic device and a cross-sectional area that is associated with a sensitivity of the fluidic device. The electronics layer includes electrodes configured to measure an electrical resistance through a portion of the capture material. |
FILED | Wednesday, March 14, 2018 |
APPL NO | 16/494230 |
CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) Original (OR) Class B01L 3/502715 (20130101) B01L 2300/069 (20130101) B01L 2300/0645 (20130101) B01L 2300/0867 (20130101) B01L 2300/0896 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/08 (20130101) G01N 33/48707 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323045 | Lujan et al. |
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FUNDED BY |
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APPLICANT(S) | BOISE STATE UNIVERSITY (Boise, Idaho) |
ASSIGNEE(S) | |
INVENTOR(S) | Trevor Lujan (Boise, Idaho); Sean Nelson (Meridian, Idaho); Madison Wale (Boise, Idaho); Danielle Siegel (Boise, Idaho); Jaremy Creechley (Laramie, Wyoming) |
ABSTRACT | A system may include a blade die, a first clamping caul positioned on a first side of the blade die, and a second clamping caul positioned on a second side of the blade die. A molding surface of the blade die and a molding surface of the first clamping caul may be configured to bend a first interchangeable blade positioned therebetween into a first shape in response to a first compression force. A second molding surface of the blade die and a molding surface of the second clamping caul may be configured to bend a second interchangeable blade positioned therebetween into a second shape in response to a second compression force. |
FILED | Monday, April 19, 2021 |
APPL NO | 17/234606 |
CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 28/34 (20130101) Original (OR) Class B21D 43/003 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323919 | SRIDHAR et al. |
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FUNDED BY |
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APPLICANT(S) | Xavier University of Louisiana (New Orleans, Louisiana) |
ASSIGNEE(S) | |
INVENTOR(S) | Jayalakshmi SRIDHAR (New Orleans, Louisiana); Melyssa BRATTON (New Orleans, Louisiana); Rajesh KOMATI (Thibodaux, Louisiana) |
ABSTRACT | The present disclosure relates to compounds that act as protein kinase inhibitors, especially RPS6K1 and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ and/or HER2+ breast cancer, prostate cancer, lung cancer, and metastatic cancer. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/232469 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 209/56 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323926 | Zhang et al. |
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FUNDED BY |
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APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
INVENTOR(S) | Zhong-Yin Zhang (West Lafayette, Indiana); Jianping Lin (West Lafayette, Indiana) |
ABSTRACT | The present disclosure relates to novel lymphoid-specific tyrosine phosphatase (LYP, encoded by the PTPN22 gene) inhibitors, and to methods of making and using the novel LYP inhibitors. Thus, the compounds according to the disclosure may be used for treating diseases or disorders associated with PTPN22 genetic polymorphism, including type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosis, Graves' disease, Addison's disease, vitiligo, juvenile arthritis, Hashimoto thyroiditis, and other rarer diseases. Furthermore, these LYP inhibitors may be served for a novel class of cancer immunotherapy. The compounds can be injected or orally administered. |
FILED | Friday, February 05, 2021 |
APPL NO | 17/168212 |
CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 215/56 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 405/12 (20130101) C07D 409/06 (20130101) C07D 471/04 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323928 | MALONEY et al. |
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FUNDED BY |
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APPLICANT(S) | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland); VANDERBILT UNIVERSITY (Nashville, Tennessee); The UAB Research Foundation (Birmingham, Alabama); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
ASSIGNEE(S) | |
INVENTOR(S) | David J. MALONEY (Point of Rocks, Maryland); Alex Gregory WATERSON (Nashville, Tennessee); Ganesh Rai BANTUKALLU (Arlington, Virginia); Kyle Ryan BRIMACOMBE (Bethesda, Maryland); Plamen CHRISTOV (Nashville, Tennessee); Chi V. DANG (Penn Valley, Pennsylvania); Victor DARLEY-USMAR (Birmingham, Alabama); Xin HU (Frederick, Maryland); Ajit JADHAV (Chantilly, Virginia); Somnath JANA (Nashville, Tennessee); Kwangho KIM (Nashville, Tennessee); Jennifer L. KOUZNETSOVA (Silver Spring, Maryland); William J. MOORE (Hagerstown, Maryland); Bryan T. MOTT (College Park, Maryland); Leonard M. NECKERS (Bethesda, Maryland); Anton SIMEONOV (Bethesda, Maryland); Gary Allen SULIKOWSKI (Nashville, Tennessee); Daniel Jason URBAN (Rockville, Maryland); Shyh Ming YANG (Doylestown, Pennsylvania) |
ABSTRACT | Provided is a compound of formula (I)[Formula (I) should be inserted here], in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell. |
FILED | Thursday, January 28, 2021 |
APPL NO | 17/160868 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/415 (20130101) A61K 31/422 (20130101) A61K 31/427 (20130101) A61K 31/437 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/501 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4155 (20130101) A61K 31/4178 (20130101) A61K 31/4439 (20130101) A61K 31/5355 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 231/20 (20130101) Original (OR) Class C07D 231/38 (20130101) C07D 401/04 (20130101) C07D 403/04 (20130101) C07D 403/06 (20130101) C07D 409/04 (20130101) C07D 413/04 (20130101) C07D 417/04 (20130101) C07D 417/14 (20130101) C07D 471/04 (20130101) C07D 495/04 (20130101) C07D 495/14 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323932 | Montano et al. |
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FUNDED BY |
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APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
ASSIGNEE(S) | |
INVENTOR(S) | Monica Montano (Shaker Heights, Ohio); Matthew C. Lawes (Shaker Heights, Ohio) |
ABSTRACT | Compounds for use in treating cancer include inhibitors of KDM5B and/or inducers of HEXIM1 and/or p21 are described herein. |
FILED | Monday, April 19, 2021 |
APPL NO | 17/234343 |
CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 241/44 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323933 | Suto et al. |
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FUNDED BY |
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APPLICANT(S) | Southern Research Institute (Birmingham, Alabama) |
ASSIGNEE(S) | UAB Research Foundation (Birmingham, Alabama) |
INVENTOR(S) | Mark J. Suto (Homewood, Alabama); Vandana V. Gupta (Birmingham, Alabama); Wei Zhang (Wilmington, Massachusetts); Joanne Murphy-Ullrich (Birmingham, Alabama) |
ABSTRACT | The present disclosure is concerned with piperazine-2,5-diones that are capable of inhibiting TGF-β and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, and methods of treating fibrotic conditions using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
FILED | Monday, August 05, 2019 |
APPL NO | 17/265357 |
CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/04 (20180101) A61P 35/04 (20180101) Heterocyclic Compounds C07D 241/08 (20130101) C07D 241/52 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323934 | Pierce et al. |
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FUNDED BY |
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APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Joshua G. Pierce (Raleigh, North Carolina); Jonathan J. Mills (Raleigh, North Carolina) |
ABSTRACT | Provided herein are oxazolidinone derivatives that can exhibit anti-microbial activity and/or activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity anti-microbial activity (e.g., potent activity against Gram-positive positive bacteria including methicillin-resistant Staphylococcus aureus). The compounds can exhibit potent activity against biofilms. In some cases, the compounds can exhibit both anti-microbial activity and biofilm modulation properties. |
FILED | Monday, November 23, 2020 |
APPL NO | 17/101722 |
CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/76 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 29/16 (20130101) A61L 31/08 (20130101) A61L 31/16 (20130101) A61L 2300/204 (20130101) A61L 2300/404 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 263/40 (20130101) Original (OR) Class C07D 263/46 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323941 | Sibley et al. |
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FUNDED BY |
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APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland); The University of Kansas (Lawrence, Kansas) |
ASSIGNEE(S) | |
INVENTOR(S) | David R. Sibley (Bethesda, Maryland); Amy Elizabeth Moritz (Bethesda, Maryland); R. Benjamin Free (Bethesda, Maryland); Joseph P. Steiner (Bethesda, Maryland); Noel Terrence Southall (Rockville, Maryland); Marc Ferrer (Rockville, Maryland); Xin Hu (Rockville, Maryland); Warren S. Weiner (Boston, Massachusetts); Jeffrey Aubé (Chapel Hill, North Carolina); Kevin Frankowski (Chapel Hill, North Carolina) |
ABSTRACT | The disclosure of a compound of Formula (I) or a pharmaceutically acceptable salt thereof (I) The variables W, R1, R2, R3, and R4 are defined in the disclosure. The disclosure provides a compound or salt of Formula (I) together with a pharmaceutically acceptable carrier. The disclosure also provides methods of treating a patient for Parkinson's disease and related syndromes, dyskinesia, especially dyskinesias secondary to treating Parkinson's disease with L-DOPA, neurodegenerative disorders such as Alzheimer's disease and dementia, Huntington's disease, restless legs syndrome, bipolar disorder and depression, schizophrenia, cognitive dysfunction, or substance use disorders, the methods comprising administering a compound of Formula I or salt thereof to the patient. The disclosure provides combination methods of treatment in which the compound of Formula (I) is administered to the patient together with one or more additional active agents. |
FILED | Friday, April 14, 2017 |
APPL NO | 16/093365 |
CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 209/42 (20130101) C07D 213/65 (20130101) C07D 213/81 (20130101) C07D 235/24 (20130101) C07D 295/185 (20130101) C07D 307/85 (20130101) C07D 317/64 (20130101) C07D 333/70 (20130101) C07D 401/12 (20130101) Original (OR) Class C07D 405/12 (20130101) C07D 409/12 (20130101) C07D 471/04 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323949 | Fields et al. |
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FUNDED BY |
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APPLICANT(S) | FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (BOCA RATON, Florida); H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida) |
ASSIGNEE(S) | FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (Boca Raton, Florida); H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida) |
INVENTOR(S) | Gregg B. Fields (Palm Beach Gardens, Florida); Conor Lynch (Tampa, Florida) |
ABSTRACT | Novel compounds (small molecules) that potently and selectively inhibit MMP-13 (i.e., MMP-13 inhibitors) are used for treatment of multiple myeloma. The MMP-13 inhibitors described herein are highly selective for MMP-13 and when administered to an individual in need thereof, the compounds selectively kill multiple myeloma cells, reduce growth of multiple myeloma cells, inhibit multiple myeloma-induced osteoclastogenesis, and increase survival time in the individual. |
FILED | Friday, June 28, 2019 |
APPL NO | 17/272135 |
CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 405/12 (20130101) C07D 405/14 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323987 | Garg et al. |
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APPLICANT(S) | The Regents of the University of California (Oakland, California) |
ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
INVENTOR(S) | Neil K. Garg (Oakland, California); Evan R. Darzi (Oakland, California); Joyann S. Barber (Oakland, California); Robert Susick (Oakland, California); Jason Chari (Oakland, California); Katie Spence (Oakland, California) |
ABSTRACT | Methods for the synthesis of polycyclic aromatic hydrocarbons and synthesis platforms for performing such syntheses are provided. Methods and platforms are provided that allow for the synthesis of aza-polycyclic aromatic hydrocarbons by an expedient ring assembly. Methods and platforms allow for a modular approach to synthesis that provide multiple new C—C bonds in sequential pericyclic reactions, thus giving access to compounds with multiple axes of substitution. |
FILED | Tuesday, August 20, 2019 |
APPL NO | 17/269224 |
CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/2226 (20130101) B01J 31/2291 (20130101) B01J 31/2419 (20130101) B01J 2231/4272 (20130101) B01J 2531/824 (20130101) Heterocyclic Compounds C07D 209/58 (20130101) C07D 209/90 (20130101) C07D 217/04 (20130101) C07D 273/04 (20130101) C07D 333/38 (20130101) C07D 409/04 (20130101) C07D 413/04 (20130101) C07D 417/14 (20130101) C07D 471/04 (20130101) C07D 471/14 (20130101) C07D 491/052 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0053 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323996 | Chang et al. |
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FUNDED BY |
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APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Pamela Chang (Ithaca, New York); Bibudha Parasar (Ithaca, New York); Lin Han (Ithaca, New York) |
ABSTRACT | A composition having the following structure: wherein: R1 is OH, ester group, ether group, amine, thiol, thioether, halide, or a group containing an alkynyl or azido functionality; R2 is H, OH, ester group, ether group, amine, thiol, thioether, halide, or a group containing an alkynyl or azido functionality; R3 is a group containing a reactive functionality capable of covalent binding to a thiol or amine; and R4 is H, OH, ester group, ether group, amine, thiol, thioether, halide, or a group containing an alkynyl or azido functionality; wherein one of R1, R2 and R4 is a group containing an alkynyl or azido functionality. Also disclosed is a method for profiling changes in BSH enzyme activity by attaching active BSH enzymes in a sample to the probe shown above, attaching a tag to the probe, and detecting the active BSH enzymes to obtain an activity profile. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/231432 |
CURRENT CPC | Steroids C07J 43/003 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 2333/98 (20130101) G01N 2800/065 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323998 | Micalizio et al. |
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FUNDED BY |
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APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire) |
ASSIGNEE(S) | |
INVENTOR(S) | Glenn C. Micalizio (Norwich, Vermont); Arti B. Gaur (Hanover, New Hampshire) |
ABSTRACT | The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds to treat a disease, such as a brain tumor and, particularly, a glioma. |
FILED | Thursday, September 05, 2019 |
APPL NO | 17/272091 |
CURRENT CPC | Steroids C07J 1/0055 (20130101) C07J 7/002 (20130101) C07J 75/005 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324003 | ANDRABI et al. |
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FUNDED BY |
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APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Raiees ANDRABI (La Jolla, California); Dennis BURTON (La Jolla, California) |
ABSTRACT | The present application relates to epitope-targeted SIV and HIV vaccines. The invention provides novel envelope glycoproteins which may be utilized as HIV-1 vaccine immunogens, antigens for crystallization, and for identification of broadly neutralizing antibodies. The invention encompasses preparation and purification of immunogenic compositions which are formulated into vaccines of the present invention. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/231415 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 9/127 (20130101) A61K 39/21 (20130101) A61K 39/39 (20130101) A61K 47/08 (20130101) A61K 47/10 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 5/08 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2740/15022 (20130101) C12N 2750/14143 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56988 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324004 | PAHAN |
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FUNDED BY |
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APPLICANT(S) | Rush University Medical Center (Chicago, Illinois) |
ASSIGNEE(S) | Rush University Medical Center (Chicago, Illinois) |
INVENTOR(S) | Kalipada PAHAN (Skokie, Illinois) |
ABSTRACT | Compositions for inhibiting the binding between ACE2 and SARS-CoV-2 spike S1 are disclosed. Methods of treating COVID-19 are disclosed. Methods of making an in vivo model of COVID-19 are also disclosed. |
FILED | Wednesday, December 23, 2020 |
APPL NO | 17/133035 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 38/00 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324014 | McFADDEN et al. |
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FUNDED BY |
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APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona); Oncomyx Therapeutics, Inc. (Phoenix, Arizona) |
ASSIGNEE(S) | |
INVENTOR(S) | Douglas Grant McFADDEN (Tempe, Arizona); Mohammed Masmudur RAHMAN (Chandler, Arizona); Nancy VILLA (Tempe, Arizona); Lino TORRES-DOMINGUEZ (Tempe, Arizona); Lina FRANCO ACHURY (Tempe, Arizona); Leslie Lynne SHARP (Rancho Santa Fe, California) |
ABSTRACT | Disclosed herein, in certain embodiments, are recombinant myxoma viruses (MYXVs) and nucleic acid constructs encoding the recombinant MYXVs. In some embodiments, the MYXVs are engineered to inactivate or attenuate an activity or expression level of an M153 protein. In some embodiments, the MYXVs are engineered to express one or more transgenes such as a tumor necrosis factor (TNF), interleukin-12 (IL-12), or decorin. Also disclosed herein, in certain embodiments, are methods of using the MYXVs. Some embodiments include providing a MYXV as described herein to a subject in need thereof. |
FILED | Thursday, June 24, 2021 |
APPL NO | 17/357624 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/275 (20130101) A61K 45/06 (20130101) A61K 2039/572 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 14/525 (20130101) C07K 14/5434 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324017 | HARDING et al. |
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FUNDED BY |
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APPLICANT(S) | VaxNewMo LLC (St. Louis, Missouri) |
ASSIGNEE(S) | |
INVENTOR(S) | Christian HARDING (St. Louis, Missouri); Mario FELDMAN (St. Louis, Missouri) |
ABSTRACT | Provided herein are glycosylated ComP proteins, fragments and fusion proteins thereof, and methods of making, for example, for use in the production of conjugate vaccines. Also provided herein are conjugate vaccines against diseases including bacterial diseases. |
FILED | Friday, June 14, 2019 |
APPL NO | 17/251994 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/05 (20130101) A61K 39/092 (20130101) A61K 39/0266 (20130101) A61K 2039/6037 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/195 (20130101) Original (OR) Class C07K 2319/55 (20130101) C07K 2319/91 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324023 | Barber |
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FUNDED BY |
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APPLICANT(S) | Glen N. Barber (Miami, Florida) |
ASSIGNEE(S) | |
INVENTOR(S) | Glen N. Barber (Miami, Florida) |
ABSTRACT | Modulators of STING are able to upregulate or down regulate immune responses. Administration of such modulators can be used to treat diseases or other undesirable conditions in a subject either directly or in combination with other agents. |
FILED | Thursday, June 24, 2021 |
APPL NO | 17/357822 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/136 (20130101) A61K 31/196 (20130101) A61K 31/517 (20130101) A61K 31/711 (20130101) A61K 31/713 (20130101) A61K 31/4748 (20130101) A61K 31/7048 (20130101) A61K 38/1709 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Peptides C07K 14/4702 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/143333 (20150115) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324024 | BRISCOE et al. |
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FUNDED BY |
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APPLICANT(S) | THE CHIDLREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
INVENTOR(S) | David M. BRISCOE (Sharon, Massachusetts); Diane R. BIELENBERG (Andover, Massachusetts); Johannes WEDEL (Jamaica Plain, Massachusetts) |
ABSTRACT | Provided herein are methods and compositions comprising or using mutant semaphorin polypeptides. |
FILED | Tuesday, August 27, 2019 |
APPL NO | 17/271380 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 14/4703 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324032 | Burnett, Jr. |
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FUNDED BY |
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APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
INVENTOR(S) | John C. Burnett, Jr. (Rochester, Minnesota) |
ABSTRACT | Analogues of an alternatively spliced form of atrial natriuretic peptide (MANP) that exhibit pGC-A gain of function and can be used to treat cardiorenal and metabolic disease are described herein. |
FILED | Friday, June 25, 2021 |
APPL NO | 17/359088 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) A61P 13/12 (20180101) Peptides C07K 14/58 (20130101) Original (OR) Class C07K 14/582 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324035 | Witte et al. |
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FUNDED BY |
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APPLICANT(S) | The Regents of the University of California (Oakland, California); California Institute of Technology (Pasadena, California); The Olivia Newton-John Cancer Research Institute (Victoria, Australia) |
ASSIGNEE(S) | The Regents of the University of California (Oakland, California); California Institute of Technology (Pasadena, California); The Olivia Newton-John Cancer Research Institute (Victoria, Australia) |
INVENTOR(S) | Owen N. Witte (Sherman Oaks, California); Jami McLaughlin Witte (Sherman Oaks, California); Antoni Ribas (Los Angeles, California); Lili Yang (Los Angeles, California); Michael T. Bethune (Castro Valley, California); Jonathan Cebon (New York, New York); Katherine Woods (New York, New York); Ashley J. Knights (Chadstone, Australia); David Baltimore (Pasadena, California) |
ABSTRACT | Tumor-specific T cell receptor (TCR) gene transfer enables specific and potent immune targeting of tumor antigens. The canonical cancer-testis antigen, NY-ESO-1, is not expressed in normal tissues but is aberrantly expressed across a broad array of cancer types. It has also been targeted with A2-restricted TCR gene therapy without adverse events or notable side effects. To enable the targeting of NY-ESO-1 in a broader array of HLA haplotypes, we isolated TCRs specific for NY-ESO-1 epitopes presented by four MHC molecules: HLA-A2, -B07, -B18, and -C03. Using these TCRs, we have developed an approach to extend TCR gene therapies targeting NY-ESO-1 to patient populations beyond those expressing HLA-A2. |
FILED | Wednesday, September 04, 2019 |
APPL NO | 17/273192 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/86 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324043 | REMALEY et al. |
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FUNDED BY |
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APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Dept of Health and Human Services (Bethesda, Maryland); Novo Nordisk A/S (Bagsværd, Germany) |
ASSIGNEE(S) | |
INVENTOR(S) | Alan Thomas REMALEY (Bethesda, Maryland); Soumitra Shanker GHOSH (San Diego, California); Madhav N. DEVALARAJA (Acton, Massachusetts); Chih-Hung LO (Rockville, Maryland); Denis O. SVIRIDOV (Rockville, Maryland); Anna WOLSKA (Washington, District of Columbia) |
ABSTRACT | The disclosure provides apolipoprotein C-II (apoC-II) mimetic peptides and methods for treating hypertriglyceridemia in a patient with an effective amount of an apoC-II mimetic peptide. |
FILED | Tuesday, March 09, 2021 |
APPL NO | 17/195766 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/1709 (20130101) A61K 38/1722 (20130101) Peptides C07K 14/775 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324044 | Esteves et al. |
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FUNDED BY |
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APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
INVENTOR(S) | Miguel Sena Esteves (Westford, Massachusetts); Sourav Roy Choudhury (Newton, Massachusetts) |
ABSTRACT | The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same. |
FILED | Thursday, April 22, 2021 |
APPL NO | 17/237095 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0025 (20130101) A61K 48/0058 (20130101) Peptides C07K 7/00 (20130101) C07K 7/04 (20130101) C07K 14/00 (20130101) C07K 14/005 (20130101) C07K 14/075 (20130101) C07K 14/775 (20130101) Original (OR) Class C07K 19/00 (20130101) C07K 2319/01 (20130101) C07K 2319/30 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/79 (20130101) C12N 15/86 (20130101) C12N 2750/14145 (20130101) C12N 2810/85 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324050 | Crowe, Jr. et al. |
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FUNDED BY |
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APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
ASSIGNEE(S) | |
INVENTOR(S) | James E. Crowe, Jr. (Nashville, Tennessee); Mary Estes (Houston, Texas) |
ABSTRACT | The present disclosure is directed to antibodies binding to and neutralizing norovirus and methods for use thereof. Thus, in accordance with the present disclosure, there is provided a method of detecting a norovirus infection in a subject comprising (a) contacting a sample from the subject with an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences; and (b) detecting norovirus in the sample by binding of the antibody or antibody fragment to a norovirus antigen in the sample. |
FILED | Tuesday, August 27, 2019 |
APPL NO | 17/271843 |
CURRENT CPC | Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/55 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/08 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324051 | CROWE, Jr. et al. |
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FUNDED BY |
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APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
ASSIGNEE(S) | |
INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee); Andrew I. FLYAK (Nashville, Tennessee); Alexander BUKREYEV (Galveston, Texas); Philipp ILINYKH (Galveston, Texas) |
ABSTRACT | The present disclosure is directed to antibodies binding to Marburg virus (MARV) glycoprotein (GP) and methods of use therefore. |
FILED | Thursday, July 01, 2021 |
APPL NO | 17/365429 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 16/468 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324053 | Connors et al. |
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FUNDED BY |
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APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
INVENTOR(S) | Mark Connors (Bethesda, Maryland); Jinghe Huang (Derwood, Maryland); Byong Ha Kang (Rockville, Maryland); John Mascola (Rockville, Maryland); Elise Ishida (Chevy Chase, Maryland); Tongqing Zhou (Boyds, Maryland); Peter Kwong (Washington, District of Columbia); Anqi Zheng (Boyds, Maryland) |
ABSTRACT | Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed. |
FILED | Friday, June 25, 2021 |
APPL NO | 17/358522 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/468 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 16/2809 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56988 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324057 | CHOU et al. |
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FUNDED BY |
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APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
INVENTOR(S) | Janet S. CHOU (Cambridge, Massachusetts); Raif S. GEHA (Belmont, Massachusetts) |
ABSTRACT | Described herein are methods and compositions for treating graft versus host disease. Additionally, described herein are methods and compositions for treating diabetes. Aspects of the invention relates to administering to a subject an agent that inhibits LRRC8A as a monotherapy or in combination with additional therapeutics. |
FILED | Friday, October 25, 2019 |
APPL NO | 17/288600 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/28 (20130101) A61K 45/06 (20130101) Peptides C07K 14/70521 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) C12N 2320/31 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324058 | Alba et al. |
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FUNDED BY |
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APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | George A. Alba (Boston, Massachusetts); Joseph Loscalzo (Dover, Massachusetts); Bradley A. Maron (Sharon, Massachusetts) |
ABSTRACT | Anti-NEDD9 antibodies and methods of making and using said antibodies. |
FILED | Tuesday, November 05, 2019 |
APPL NO | 17/290960 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324060 | SIERKS et al. |
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FUNDED BY |
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APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (SCOTTSDALE, Arizona) |
ASSIGNEE(S) | |
INVENTOR(S) | Michael SIERKS (Ft. McDowell, Arizona); Huilai TIAN (Tempe, Arizona) |
ABSTRACT | The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau. |
FILED | Friday, May 21, 2021 |
APPL NO | 17/327462 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/005 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/30 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2800/2821 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324065 | KEANE et al. |
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FUNDED BY |
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APPLICANT(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
ASSIGNEE(S) | |
INVENTOR(S) | Robert W. KEANE (Miami, Florida); W. Dalton DIETRICH (Miami, Florida); Nadine KERR (Miami, Florida); Shu WU (Miami, Florida); Juan Pablo DE RIVERO VACCARI (Miami, Florida) |
ABSTRACT | The present invention provides compositions and methods for reducing inflammation in the lungs of a mammal that is afflicted by a condition that leads to inflammation in the lungs. The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s). |
FILED | Friday, June 25, 2021 |
APPL NO | 17/358582 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) A61K 39/3955 (20130101) A61K 39/39541 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 25/00 (20180101) A61P 25/14 (20180101) A61P 25/28 (20180101) A61P 29/00 (20180101) A61P 37/06 (20180101) Peptides C07K 16/18 (20130101) C07K 16/24 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324074 | Dimitrov et al. |
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FUNDED BY |
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APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
INVENTOR(S) | Dimiter S. Dimitrov (Pittsburgh, Pennsylvania); Zhongyu Zhu (Frederick, Maryland); Sneha Ramakrishna (Bethesda, Maryland); Terry J. Fry (Aurora, Colorado) |
ABSTRACT | An affinity matured anti-CD22 human monoclonal antibody exhibiting significantly higher affinity (less than 50 pM) compared to the parental antibody (affinity of about 2 nM) is described. The anti-CD22 variant antibody or a fragment thereof, such as a single-chain variable fragment (scFv), can be used as the antigen-binding portion of chimeric antigen receptors (CARs), antibody-drug conjugates (ADCs), immunotoxins or multi-specific antibodies for the treatment of B-cell malignancies. |
FILED | Thursday, July 11, 2019 |
APPL NO | 17/259334 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) A61K 35/17 (20130101) A61K 47/6803 (20170801) A61K 47/6851 (20170801) A61K 2039/505 (20130101) Peptides C07K 14/705 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/53 (20130101) C07K 2317/94 (20130101) C07K 2317/565 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324078 | Diaz et al. |
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FUNDED BY |
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APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
ASSIGNEE(S) | |
INVENTOR(S) | Luis Diaz (Ellicot City, Maryland); Bert Vogelstein (Baltimore, Maryland); Kenneth W. Kinzler (Baltimore, Maryland); Nickolas Papadopoulos (Towson, Maryland); Dung Le (Lutherville, Maryland); Drew M. Pardoll (Brookville, Maryland); Suzanne L. Topalian (Brookville, Maryland) |
ABSTRACT | Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce. |
FILED | Tuesday, June 22, 2021 |
APPL NO | 17/354656 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/30 (20130101) C07K 16/40 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2827 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 113/11052 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324086 | NDHLOVU et al. |
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FUNDED BY |
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APPLICANT(S) | University of Hawaii (Honolulu, Hawaii) |
ASSIGNEE(S) | |
INVENTOR(S) | Lishomwa C. NDHLOVU (Honolulu, Hawaii); Toshiro NIKI (Honolulu, Hawaii) |
ABSTRACT | An antibody targeting Galectin-9 is provided as are methods of using the same treatment of chronic immune conditions such as infections, inflammatory diseases and cancer, in particular malignant mesothelioma. |
FILED | Friday, July 12, 2019 |
APPL NO | 17/260077 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2851 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324090 | Khan et al. |
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FUNDED BY |
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APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
INVENTOR(S) | Javed Khan (Derwood, Maryland); Sivasubramanian Baskar (Ellicott City, Maryland); Rimas J. Orentas (Seattle, Washington); Dimiter S. Dimitrov (Pittsburgh, Pennsylvania); Zhongyu Zhu (Frederick, Maryland); Tai Chi Cheuk (Germantown, Maryland) |
ABSTRACT | Monoclonal antibodies selected from immunized mice, immunized rabbits and a human scFv library that specifically bind fibroblast growth factor receptor 4 (FGFR4) are described. Chimeric antigen receptors, antibody-drug conjugates, immunoconjugates, bispecific antibodies and immunoliposomes comprising the disclosed FGFR4-specific antibodies are also described. The antibody compositions can be used to diagnose or treat a FGFR4-positive cancer, such as rhabdomyosarcoma, lung cancer, liver cancer, breast cancer, pancreatic cancer or prostate cancer. |
FILED | Wednesday, June 23, 2021 |
APPL NO | 17/355703 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39558 (20130101) A61K 47/6803 (20170801) A61K 47/6849 (20170801) A61K 47/6911 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2863 (20130101) Original (OR) Class C07K 2317/77 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324110 | WISNIEWSKI et al. |
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FUNDED BY |
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APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Thomas M. WISNIEWSKI (Staten Island, New York); Fernando GONI (New York, New York) |
ABSTRACT | The present invention relates to antibodies and binding fragments thereof that bind the β-sheet secondary structure of a pathological monomeric or oligomeric non-fibrillar proteins without binding to the non-toxic, non-pathological forms of these proteins or peptides. These antibodies and binding fragments thereof are suitable for the diagnosis, prevention, and treatment of protein conformational disorders including all amyloid diseases. |
FILED | Friday, November 13, 2020 |
APPL NO | 17/098026 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 7/06 (20130101) C07K 14/00 (20130101) C07K 16/18 (20130101) C07K 16/44 (20130101) Original (OR) Class C07K 2317/30 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324311 | Skardal et al. |
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FUNDED BY |
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APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Aleksander Skardal (Clemmons, North Carolina); Thomas Shupe (Mocksville, North Carolina); Anthony Atala (Winston-Salem, North Carolina) |
ABSTRACT | Described herein are apparatus, including multi-tissue body-on-a-chip apparatus. In some embodiments, described are apparatus including at least a first, second, and third chamber in fluid communication with one another and with at least one tissue in each chamber, such as, for example, liver tissue in said first chamber; cardiac muscle tissue in said second chamber; and lung tissue in said third chamber; and a common aqueous growth media in said first, second, and third chamber. In some embodiments, the apparatus includes a fourth chamber including testicular or ovarian tissue in said fourth chamber. In some embodiments, the apparatus includes an optional fifth or sixth chamber; each said chamber includes different additional tissue selected from the group consisting of vascular endothelial, skeletal muscle, kidney, nerve, brain, and intestinal tissue (e.g., small intestine tissue and/or colon tissue). Also described are methods of using an apparatus of the present invention. |
FILED | Tuesday, October 10, 2017 |
APPL NO | 16/341521 |
CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 23/44 (20130101) C12M 29/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324313 | Allbritton et al. |
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FUNDED BY |
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APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Nancy L. Allbritton (Seattle, None); Christopher E. Sims (Seattle, None); Yuli Wang (Lynnwood, None); Pavak Kirit Shah (Carrboro, None) |
ABSTRACT | An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe). |
FILED | Monday, June 28, 2021 |
APPL NO | 17/361039 |
CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) B01J 2219/00452 (20130101) B01J 2219/00743 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) Original (OR) Class C12M 23/20 (20130101) C12M 23/22 (20130101) C12M 25/04 (20130101) C12M 25/16 (20130101) C12M 47/02 (20130101) C12M 47/04 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324329 | Schulz |
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FUNDED BY |
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APPLICANT(S) | ViaCyte, Inc. (San Diego, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Thomas C. Schulz (Athens, Georgia) |
ABSTRACT | The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof. |
FILED | Monday, May 24, 2021 |
APPL NO | 17/328980 |
CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 27/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0603 (20130101) C12N 5/0606 (20130101) Original (OR) Class C12N 5/0676 (20130101) C12N 2501/11 (20130101) C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/41 (20130101) C12N 2501/105 (20130101) C12N 2501/115 (20130101) C12N 2501/117 (20130101) C12N 2501/195 (20130101) C12N 2501/415 (20130101) C12N 2501/998 (20130101) C12N 2506/02 (20130101) C12N 2509/00 (20130101) C12N 2511/00 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324351 | Kranzusch et al. |
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FUNDED BY |
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APPLICANT(S) | Presodent and Fellows of Harvard College (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Philip J. Kranzusch (Bringhton, Massachusetts); John J. Mekalanos (Newton, Massachusetts); Aaron T. Whiteley (Brookline, Massachusetts); Wen Zhou (Boston, Massachusetts) |
ABSTRACT | The present invention is based, in part, on the discovery of the human-specific regulatory control of cGAS and the structure of the active human cGAS-DNA complex, as well as compositions comprising the modified hcGAS polypeptide, hcGAS-DNA complex, hcGAS-DNA-ATP complex, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides and complexes. |
FILED | Wednesday, June 26, 2019 |
APPL NO | 17/252454 |
CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324357 | CHOUDHARY et al. |
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FUNDED BY |
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APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (BOSTON, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Amit CHOUDHARY (Boston, Massachusetts); Qingxuan ZHOU (BOSTON, Massachusetts); Praveen KOKKONDA (BOSTON, Massachusetts) |
ABSTRACT | The disclosure includes non-naturally occurring or engineered CRISPR Cas variant proteins comprising one or more functional domains and degrader compositions specifically targeting the CRISPR Cas variant proteins; compositions, systems and methods of using the CRISPR Cas variant proteins comprising one or more functional domains and degrader compounds for spatio-temporal control are also provided. |
FILED | Tuesday, August 20, 2019 |
APPL NO | 17/270358 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/506 (20130101) A61K 31/7088 (20130101) A61K 38/465 (20130101) A61K 48/00 (20130101) Peptides C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324360 | CHEN et al. |
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FUNDED BY |
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APPLICANT(S) | The Regents of the University of California (Oakland, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Yvonne Y. CHEN (Los Angeles, California); Patrick HO (Fremont, California) |
ABSTRACT | Compositions and methods are provided for the cell-mediated targeted killing of diseased cells based on the presence of an intracellular antigen, rather than a surface-bound marker. The targeting cells are modified to express a cytotoxic protein that is delivered into a targeted cell, and after delivery is selectively activated by the presence of a cytoplasmic protein of interest. In one embodiment of the invention, the cytotoxic molecule is a Granzyme B (GrB) polypeptide. In the compositions of the invention, GrB is modified to render its cytotoxic enzymatic functions inactive, until the presence of an intracellular antigen unlocks the GrB molecule to enable enzymatic activities. |
FILED | Thursday, June 24, 2021 |
APPL NO | 17/357704 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/482 (20130101) Peptides C07K 14/47 (20130101) C07K 14/4702 (20130101) C07K 16/40 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/64 (20130101) C12N 9/6467 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2510/00 (20130101) Enzymes C12Y 304/21079 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324370 | Yin et al. |
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FUNDED BY |
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APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Hao Yin (Cambridge, Massachusetts); Wen Xue (Cambridge, Massachusetts); Daniel G. Anderson (Framingham, Massachusetts); Joseph R. Dorkin (Somerville, Massachusetts); Tyler E. Jacks (Newton, Massachusetts) |
ABSTRACT | The present disclosure relates to compositions and methods for modifying a gene sequence, and for systems for deliverying such compositions. For example, the disclosure relates to modifying a gene sequence using a CRISPR-Cas9 or other nucleic acid editing system, and methods and delivery systems for achieving such gene modification, such as viral or non-viral delivery systems. |
FILED | Monday, March 08, 2021 |
APPL NO | 17/195625 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/85 (20130101) C12N 15/86 (20130101) C12N 15/88 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 2310/20 (20170501) C12N 2750/14143 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324376 | Dhara et al. |
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FUNDED BY |
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APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire); Memorial Sloan Kettering Cancer Center (New York, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Surajit Dhara (Hanover, New Hampshire); Steven D. Leach (Hanover, New Hampshire); Sagar Chhangawala (New York, New York); Christina Leslie (New York, New York) |
ABSTRACT | The present disclosure relates to an array-based assay for transposase-accessible chromatin and prognostic molecular markers of treatment-resistant/early recurrent cancer. |
FILED | Tuesday, August 13, 2019 |
APPL NO | 17/268195 |
CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) C12Q 1/6886 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324380 | DE ABREU RIBEIRO et al. |
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FUNDED BY |
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APPLICANT(S) | Cairn Biosciences, Inc. (San Francisco, California) |
ASSIGNEE(S) | |
INVENTOR(S) | M. Susana G. DE ABREU RIBEIRO (San Francisco, California); Catherine I. LACAYO (Fremont, California); Mary J. C. LUDLAM (San Francisco, California); Salome Calado BOTELHO (San Francisco, California) |
ABSTRACT | The present invention provides multicistronic reporter vectors, acceptor stem cells for receiving multicistronic reporter vectors, and multireporter cells for use in assays for profiling two or more polypeptides in live cells, wherein the vectors comprise a reporter polypeptide under the control of a lineage specific promoter to act as a barcode for a specific cell type. Methods of making multicistronic reporter vectors, acceptor cells for receiving multicistronic reporter vectors, and multireporter cells are provided. Libraries and kits comprising multicistronic reporter vectors, acceptor cells for receiving multicistronic reporter vectors, and multireporter cells are provided. Methods of profiling/assaying the multireporter cells and multireporter cell libraries are provided. |
FILED | Friday, August 16, 2019 |
APPL NO | 17/269223 |
CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) C12N 15/1086 (20130101) Original (OR) Class C12N 2830/20 (20130101) C12N 2840/20 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324383 | Jaffee et al. |
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FUNDED BY |
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APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
ASSIGNEE(S) | |
INVENTOR(S) | Elizabeth A. Jaffee (Baltimore, Maryland); Nina Chu (Baltimore, Maryland); Jacquelyn Winifred Zimmerman (Baltimore, Maryland) |
ABSTRACT | In one aspect, compositions are provided for the early diagnosis and treatment of pancreatic ductal adenocarcinoma and include microRNAs, e.g. miR-21 and inhibitors thereof. The treatment compositions can be useful for early detection, and for intercepting developing premalignant pancreatic lesions and other KRAS-driven premalignancies. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/233378 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/178 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324385 | Taylor |
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FUNDED BY |
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APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
ASSIGNEE(S) | |
INVENTOR(S) | Hugh Taylor (Easton, Connecticut) |
ABSTRACT | The invention includes compositions and methods for the treating or preventing endometriosis in a subject in need thereof. In one aspect, the invention relates to compositions and methods for modulating let-7 microRNA. |
FILED | Friday, July 12, 2019 |
APPL NO | 17/258879 |
CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/531 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324387 | Lewin et al. |
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FUNDED BY |
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APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
ASSIGNEE(S) | Univeristy of Florida Research Foundation, Incorporated (Gainesville, Florida); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
INVENTOR(S) | Alfred S. Lewin (Gainesville, Florida); William W. Hauswirth (Gainesville, Florida); Michael T. Massengill (Gainesville, Florida); William Beltran (Wynnewood, Pennsylvania); Gustavo D. Aguirre (Media, Pennsylvania); Artur Cideciyan (Lafayette Hill, Pennsylvania); Samuel Jacobson (Penn Valley, Pennsylvania) |
ABSTRACT | Aspects of the disclosure relate to methods and compositions for treating retinitis pigmentosa. In some aspects, the disclosure provides compositions and methods for delivering an interfering nucleic acid (for example an interfering RNA) to a subject in order to reduce expression of one or both alleles of an endogenous rho gene (for example a mutant rho allele associated with retinitis pigmentosa) in the subject. In some embodiments, a replacement rho gene that is resistant to the interfering nucleic acid also is delivered to the subject. |
FILED | Friday, May 21, 2021 |
APPL NO | 17/327609 |
CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/122 (20130101) C12N 2310/141 (20130101) C12N 2310/531 (20130101) C12N 2330/51 (20130101) C12N 2750/14143 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324396 | Daniell |
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FUNDED BY |
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APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
ASSIGNEE(S) | |
INVENTOR(S) | Henry Daniell (Media, Pennsylvania) |
ABSTRACT | Compositions and methods for producing marker free biopharmaceutical proteins in the plastids of edible plants are disclosed. Also provided are methods for oral administration of such proteins to subjects in need thereof for the treatment of disease. |
FILED | Thursday, August 22, 2019 |
APPL NO | 17/270368 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/00 (20180101) Peptides C07K 14/65 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8214 (20130101) C12N 15/8257 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324411 | BAILEY et al. |
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FUNDED BY |
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APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
INVENTOR(S) | Rachel M. BAILEY (Trophy Club, Texas); Steven J. GRAY (Southlake, Texas) |
ABSTRACT | The present disclosure provides methods and compositions for the treatment of diseases and/or disorders in a subject, including, but not limited to neurological disorders such as giant axonal neuropathy. The methods described herein include direct administration of a gene therapy (e.g. an rAAV viral vector) to a subject via injection into a vagus nerve (e.g. the left vagus nerve) of the subject. |
FILED | Wednesday, April 14, 2021 |
APPL NO | 17/230484 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) Peptides C07K 14/01 (20130101) C07K 16/081 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324412 | GNEDEVA et al. |
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FUNDED BY |
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APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Ksenia GNEDEVA (Malibu, California); Neil I. SEGIL (Altadena, California); Xizi WANG (Arcadia, California) |
ABSTRACT | A method for inducing sensory receptor regeneration includes a step of identifying a subject in need of regeneration of inner ear sensory epithelia. Yap/Tead signaling in the subject is then activated. Typically, Yap/Tead signaling is activated by introducing an expression vector into the subject such that the expression vector contacts inner ear sensory epithelia in a sufficient amount to induce regeneration thereof. Characteristically, the expression vector encodes a constitutively active YAP gene. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/231328 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0046 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324413 | Irvine et al. |
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FUNDED BY |
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APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
INVENTOR(S) | Darrell J. Irvine (Arlington, Massachusetts); Ron Weiss (Newton, Massachusetts); Yingzhong Li (Quincy, Massachusetts); Jan Lonzaric (Arlington, Massachusetts); Parisa Yousefpour (Cambridge, Massachusetts) |
ABSTRACT | Genetic circuits have been developed to regulate behaviors of replicon RNA in responses to small molecules, which has broader applications, such as for quantitative expression of cargo genes, temporary expression of immunomodulatory cytokines or antigens for better cancer immunotherapy or vaccination, and for increased safety in use of self-replicating vectors or in combination with other viral-delivery vectors. Described herein are genetic circuits suitable for systems that either require a tight off state or a slow off state, which can serve for instance where either a kill switch or prolonged protein expression (e.g., of vaccine antigens) are needed. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/231588 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/505 (20130101) A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2720/12322 (20130101) C12N 2720/12343 (20130101) C12N 2820/60 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324414 | Weiss et al. |
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FUNDED BY |
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APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); University of Massachusetts (Boston, Massachusetts) |
ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); University of Massachusetts (Boston, Massachusetts) |
INVENTOR(S) | Ron Weiss (Newton, Massachusetts); Jin Huh (Watertown, Massachusetts); Yingzhong Li (Quincy, Massachusetts); Eric Goldstein (Cambridge, Massachusetts); Hava Siegelmann (Amherst, Massachusetts) |
ABSTRACT | This disclosure provides engineered genetic systems for sequestering and/or destroying viruses, compositions and cells comprising the genetic systems, and methods of treating viral infections, reducing viral load, and/or reducing viral spread. The disclosure also provides libraries comprising elements to be incorporated into the engineered genetic systems. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/232676 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 35/28 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 15/1093 (20130101) C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2310/141 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101) C12N 2710/16643 (20130101) C12N 2800/80 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324450 | Church et al. |
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FUNDED BY |
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APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | George M. Church (Brookline, Massachusetts); Je-Hyuk Lee (Allston, Massachusetts); Richard C. Terry (Carlisle, Massachusetts); Evan R. Daugharthy (Cambridge, Massachusetts) |
ABSTRACT | Methods of making a three-dimensional matrix of nucleic acids within a cell is provided. |
FILED | Wednesday, June 30, 2021 |
APPL NO | 17/363097 |
CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324456 | Cunningham et al. |
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FUNDED BY |
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APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Brian T. Cunningham (Champaign, Illinois); Yue Zhuo (Champaign, Illinois); Brendan Harley (Urbana, Illinois); Ji Sun Choi (Urbana, Illinois); Thibault Marin (Champaign, Illinois); Yi Lu (Champaign, Illinois) |
ABSTRACT | A digital assay for a micro RNA (miRNA) or other target analyte in a sample makes use of nanoparticles that absorb light at the resonant wavelength of a photonic crystal (PC). Such nanoparticles locally quench the resonant reflection of light from the PC when present on the surface of the PC. The nanoparticles are functionalized to specifically bind to the target analyte, and the PC surface is functionalized to specifically bind to the nanoparticles that have bound to the target analyte. The sample is exposed to the functionalized nanoparticles, and the individual nanoparticles bound to the PC surface can be identified and counted based on reduced intensity values in the reflected light from the PC. The number of bound nanoparticles that are counted in this way can be correlated to the abundance of the target analyte in the sample. |
FILED | Monday, May 24, 2021 |
APPL NO | 17/328752 |
CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/554 (20130101) G01N 21/774 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324469 | Xie et al. |
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FUNDED BY |
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APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Xiaoliang Sunney Xie (Lexington, Massachusetts); Katsuyuki Shiroguchi (Arlington, Massachusetts); Peter A. Sims (Cambridge, Massachusetts); Tony Z. Jia (Cambridge, Massachusetts) |
ABSTRACT | Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided. |
FILED | Wednesday, June 30, 2021 |
APPL NO | 17/363053 |
CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6853 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324470 | Salk et al. |
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FUNDED BY |
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APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
ASSIGNEE(S) | |
INVENTOR(S) | Jesse Salk (Seattle, Washington); Lawrence A. Loeb (Bellevue, Washington); Michael Schmitt (Seattle, Washington) |
ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
FILED | Monday, June 28, 2021 |
APPL NO | 17/361245 |
CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324478 | Stegmaier |
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FUNDED BY |
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APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Kimberly Stegmaier (Jamaica Plain, Massachusetts) |
ABSTRACT | The present invention is based, in part, on the identification of TP53 dependency biomarkers, including MDM2, MDM4, USP7, and Wip1/PPM1D, as well as modulators and methods of use thereof, for identifying, assessing, preventing, and treating Ewing sarcoma. |
FILED | Wednesday, July 17, 2019 |
APPL NO | 17/260824 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325280 | Matula et al. |
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FUNDED BY |
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APPLICANT(S) | University of Washington (Seattle, Washington) |
ASSIGNEE(S) | |
INVENTOR(S) | Thomas J. Matula (Kirkland, Washington); Karol Bomsztyk (Mercer Island, Washington); Brian MacConaghy (Kent, Washington); Justin Reed (Seattle, Washington); Adam D. Maxwell (Woodinville, Washington) |
ABSTRACT | A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one embodiment, the transducers are configured to direct ultrasound energy into cylindrical wells. In other embodiments, the transducer elements are configured to direct ultrasound energy into non-cylindrical wells of a microplate. |
FILED | Friday, April 23, 2021 |
APPL NO | 17/239387 |
CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0215 (20130101) B06B 1/0629 (20130101) B06B 2201/55 (20130101) B06B 2201/70 (20130101) Apparatus for Enzymology or Microbiology; C12M 47/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/286 (20130101) Original (OR) Class Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/30 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325324 | YU et al. |
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FUNDED BY |
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APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
ASSIGNEE(S) | |
INVENTOR(S) | Yihua (Bruce) YU (Baltimore, Maryland); Marc B. TARABAN (Baltimore, Maryland); Katharine T. BRIGGS (Baltimore, Maryland) |
ABSTRACT | A method of using the relaxation rate (R1 and/or R2) of solvent NMR signal to assess whether drug products have undergone substantial chemical degradation during manufacturing, transport and/or storage. The monitoring can be performed under both static and flow conditions, in real-time and in a contact-free manner. |
FILED | Friday, March 19, 2021 |
APPL NO | 17/206373 |
CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/088 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325329 | Bandara et al. |
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FUNDED BY |
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APPLICANT(S) | Southern Methodist University (Dallas, Texas); University of Rhode Island Board of Trustees (Kingston, Rhode Island) |
ASSIGNEE(S) | |
INVENTOR(S) | Y.M. Nuwan D.Y. Bandara (Canberra, Australia); Buddini I. Karawdeniya (Canberra, Australia); Jugal Saharia (Dallas, Texas); Min Jun Kim (Plano, Texas); Jason Rodger Dwyer (Providence, Rhode Island) |
ABSTRACT | The present invention includes one or more nanopores in a SixNy membrane comprising a monoprotic surface termination, methods of making, and methods of using the one or more nanopores, where the one or more nanopores are a chemically-tuned controlled dielectric breakdown (CT-CDB) nanopore membrane, wherein the CT-CDB allows for long-term stability of measurements in the presence of only electrolyte (open pore current stability) and ability to support many molecular detection events. In addition, the CT-CBD has pore that unclog spontaneously, in response to voltage cessation or application, or both. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/232624 |
CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/127 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325368 | Lane et al. |
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FUNDED BY |
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APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Andrew Lane (Needham, Massachusetts); Jon Aster (Lexington, Massachusetts) |
ABSTRACT | The present invention is based in part on the identification of DPH1 and other members of the diphthamide synthesis pathway as biomarkers of resistance to an ADP-ribosylating toxin in a cell, and methods for identification, assessment, and treatment of a condition that is resistant to an ADP-ribosylating toxin. |
FILED | Tuesday, October 30, 2018 |
APPL NO | 16/756545 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) Original (OR) Class G01N 33/57426 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325379 | Lindsay et al. |
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FUNDED BY |
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APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (SCOTTSDALE, Arizona); RECOGNITION ANALYTIX INC. (Phoenix, Arizona) |
ASSIGNEE(S) | |
INVENTOR(S) | Stuart Lindsay (SCOTTSDALE, Arizona); Karen Anderson (SCOTTSDALE, Arizona); Mark Knappenberger (SCOTTSDALE, Arizona); Sepideh Afsari Mamaghani (SCOTTSDALE, Arizona); Jacob L. Swett (TEMPE, Arizona) |
ABSTRACT | The present disclosure provides devices, systems, and methods related to single molecule detection. In particular, the present disclosure provides devices and methods for sequence-specific detection of a nucleic acid target using current fluctuations as a readout for protein binding to the nucleic acid target. As described herein, certain aspects of the bioelectronic devices and method can be used to detect and identify any nucleic acid target for the purpose of diagnosis and/or treatment. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/232631 |
CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/021 (20130101) G01N 33/5308 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325387 | Shalek et al. |
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FUNDED BY |
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APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Alexander K. Shalek (Cambridge, Massachusetts); Christopher Smillie (Cambridge, Massachusetts); Rebecca H. Herbst (Cambridge, Massachusetts); Moshe Biton (Cambridge, Massachusetts); Aviv Regev (Cambridge, Massachusetts); Jose Ordovas-Montanes (Cambridge, Massachusetts); Ramnik Xavier (Cambridge, Massachusetts) |
ABSTRACT | The present invention provides for a human cell atlas of the colon from healthy and diseased subjects. The atlas was obtained by single sequencing of about 117,000 cells. The present invention discloses novel markers for cell types. Moreover, genes associated with disease are identified in the colon and colon specific cell types. The invention provides for diagnostic assays based on gene markers and cell composition, as well as target cell types that express genes associated with disease. Finally, disclosed are novel cell types and methods of quantitating, detecting and isolating the cell types. |
FILED | Tuesday, July 17, 2018 |
APPL NO | 16/632018 |
CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56966 (20130101) Original (OR) Class G01N 2800/065 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325392 | Buranda et al. |
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FUNDED BY |
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APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
ASSIGNEE(S) | |
INVENTOR(S) | Tione Buranda (Albuquerque, New Mexico); Jacob Ongudi Agola (Albuquerque, New Mexico); Soumik BasuRay (Dallas, Texas); Scarlett Swanson (Albuquerque, New Mexico); Angela Wandinger-Ness (Albuquerque, New Mexico); Peter C. Simons (Albuquerque, New Mexico); Virginie Bondu (Albuquerque, New Mexico) |
ABSTRACT | In one embodiment, the invention provides a method of diagnosing sepsis or a virus-related infection (often a viral hemorrhagic fever infection) in a subject by detecting and measuring the level of a set of sepsis and virus infection-associated-GTPase biomarkers in a sample obtained from the subject using multiplexed flow cytometry. Related kits are also provided. In a preferred embodiment, the invention provides point of care diagnostic methods for determining an early stage sepsis or the severity of a virus infection, especially in a hospital or other setting. |
FILED | Tuesday, February 23, 2021 |
APPL NO | 17/182859 |
CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) G01N 33/573 (20130101) Original (OR) Class G01N 2333/914 (20130101) G01N 2800/26 (20130101) G01N 2800/224 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325403 | Mrksich et al. |
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FUNDED BY |
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APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Milan Mrksich (Hinsdale, Illinois); Eric J. Berns (Park Ridge, Illinois); Maria D. Cabezas (Evanston, Illinois) |
ABSTRACT | The disclosure provides a cell-based, label-free assay compatible with high-throughput screening (HTS) that can report quantitatively on enzyme activities by measuring mass changes of substrates with MALDI-mass spectrometry. |
FILED | Tuesday, June 29, 2021 |
APPL NO | 17/362600 |
CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/00 (20130101) C12Q 1/26 (20130101) C12Q 1/37 (20130101) C12Q 1/42 (20130101) C12Q 1/44 (20130101) C12Q 1/46 (20130101) C12Q 1/48 (20130101) C12Q 1/485 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325405 | Padmanabhan et al. |
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FUNDED BY |
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APPLICANT(S) | RETHAM TECHNOLOGIES, LLC (Wauwatosa, Wisconsin) |
ASSIGNEE(S) | |
INVENTOR(S) | Anand Padmanabhan (Rochester, Minnesota); Curtis G. Jones (Wauwatosa, Wisconsin) |
ABSTRACT | Described is a method for identifying pathogenic platelet-activating antibodies in a subject's blood and particularly antibodies implicated in heparin-induced thrombocytopenia (HIT) which comprises the preparation of a platelet releasate from a normal subject's platelets, the combination of the platelet release with a normal subject's platelets, a test subject's blood sample, and analyzing the sample for platelet activation. |
FILED | Monday, April 19, 2021 |
APPL NO | 17/234182 |
CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0644 (20130101) C12N 2500/42 (20130101) C12N 2501/30 (20130101) C12N 2501/998 (20130101) C12N 2523/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 33/545 (20130101) G01N 33/6857 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325652 | Tang et al. |
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FUNDED BY |
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APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
ASSIGNEE(S) | |
INVENTOR(S) | Jialei Tang (Orlando, Florida); Vahid Ebrahimi (Orlando, Florida); Kyu Young Han (Orlando, Florida) |
ABSTRACT | An illumination system may include an illumination source, a line-projection system to simultaneously illuminate a pupil plane with a static distribution of a plurality of one-dimensional (1D) coherent beams. Each of the 1D coherent beams of the plurality of 1D coherent beams may extend lengthwise along a coherent direction between boundaries of the pupil plane, have a width along an incoherent direction perpendicular to the coherent direction, and are distributed in a parallel distribution along the incoherent direction. Each of the 1D coherent beams of the plurality of 1D coherent beams is also spatially coherent along the coherent direction and spatially incoherent along the incoherent direction. The system may further include an objective lens to form a light sheet in an imaging plane based on an incoherent superposition of the plurality of 1D coherent beams. |
FILED | Wednesday, April 21, 2021 |
APPL NO | 17/236941 |
CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 2021/6469 (20130101) G01N 2021/6478 (20130101) G01N 2201/061 (20130101) Optical Elements, Systems, or Apparatus G02B 3/06 (20130101) G02B 21/02 (20130101) G02B 21/06 (20130101) Original (OR) Class G02B 21/16 (20130101) G02B 21/26 (20130101) G02B 21/367 (20130101) G02B 27/48 (20130101) G02B 27/0927 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325656 | Liu et al. |
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FUNDED BY |
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APPLICANT(S) | University of Washington (Seattle, Washington) |
ASSIGNEE(S) | University of Washington (Seattle, Washington) |
INVENTOR(S) | Jonathan T.C. Liu (Seattle, Washington); Lindsey A. Barner (Seattle, Washington); Adam K. Glaser (Seattle, Washington) |
ABSTRACT | Apparatuses, systems, and methods for solid immersion meniscus lenses (SIMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices. |
FILED | Wednesday, June 23, 2021 |
APPL NO | 17/356135 |
CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/0032 (20130101) G02B 21/33 (20130101) Original (OR) Class G02B 21/248 (20130101) G02B 21/367 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210326653 | Zhou et al. |
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FUNDED BY |
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APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
ASSIGNEE(S) | |
INVENTOR(S) | Zongwei Zhou (Tempe, Arizona); Vatsal Sodha (San Jose, California); Jiaxuan Pang (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
ABSTRACT | Described herein are means for generation of self-taught generic models, named Models Genesis, without requiring any manual labeling, in which the Models Genesis are then utilized for the processing of medical imaging. For instance, an exemplary system is specially configured for learning general-purpose image representations by recovering original sub-volumes of 3D input images from transformed 3D images. Such a system operates by cropping a sub-volume from each 3D input image; performing image transformations upon each of the sub-volumes cropped from the 3D input images to generate transformed sub-volumes; and training an encoder-decoder architecture with skip connections to learn a common image representation by restoring the original sub-volumes cropped from the 3D input images from the transformed sub-volumes generated via the image transformations. A pre-trained 3D generic model is thus provided, based on the trained encoder-decoder architecture having learned the common image representation which is capable of identifying anatomical patterns in never before seen 3D medical images having no labeling and no annotation. More importantly, the pre-trained generic models lead to improved performance in multiple target tasks, effective across diseases, organs, datasets, and modalities. |
FILED | Wednesday, April 07, 2021 |
APPL NO | 17/224886 |
CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6259 (20130101) Original (OR) Class G06K 9/6261 (20130101) G06K 2209/05 (20130101) Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) G06N 3/0454 (20130101) Image Data Processing or Generation, in General G06T 3/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210326704 | George |
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FUNDED BY |
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APPLICANT(S) | UNIVERISTY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
ASSIGNEE(S) | |
INVENTOR(S) | Jacob Anthony George (Salt Lake City, Utah) |
ABSTRACT | A method for training an artificial intelligence (AI) model for allowing a user to intuitively control an electronic device includes positioning a plurality of sensors at a plurality of particular positions on a human body for sensing electric signals. The method also includes recording a first set of electric signals from each of the plurality of sensors in a continuous manner. At the same time, a first set of motion intents associated with a first sequence of body movement is also recorded in a continuous manner. An AI regression model is trained using a neural network to map the first set of electric signals to the first set of motion intents. In response to receiving a second set of electric signals from the plurality of sensors in a continuous manner, the AI regression model predicts a motion intent, causing the electronic device to perform an action. |
FILED | Wednesday, April 14, 2021 |
APPL NO | 17/230446 |
CURRENT CPC | Electric Digital Data Processing G06F 3/014 (20130101) G06F 3/015 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Original (OR) Class G06N 3/063 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327535 | ZHOU et al. |
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FUNDED BY |
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APPLICANT(S) | The Regents of the University of California (Oakland, California); EarlyDiagnostics, Inc. (Los Angeles, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Xianghong Jasmine ZHOU (Los Angeles, California); Wenyuan LI (Los Angeles, California); Shuo LI (Los Angeles, California); Chun-Chi LIU (Los Angeles, California); Xiaohui NI (Los Angeles, California) |
ABSTRACT | The present disclosure provides methods and systems for detecting or inferring levels of Copy Number Variants (CNVs) in cell-free nucleic acid samples to detect or assess cancer and prenatal diseases. Cell-free nucleic acid methylation sequencing data may be utilized to distinguish tumor-derived or fetal-derived sequencing reads from normal cfDNA sequencing reads. Each cell-free nucleic acid sequencing read (e.g., containing tumor or fetal methylation markers) may be classified as corresponding to a tumor/fetal-derived or a normal-plasma cell-free nucleic acid, based on the methylation cfDNA sequencing data (e.g., obtained using Bisulfite sequencing or bisulfite-free sequencing methods) and tumor/fetal methylation markers. Next, a profile of the tumor/fetal-derived sequencing read counts may be constructed and then normalized. The CNV status (e.g., gain or loss) of each genomic region may be inferred, and a diagnosis or prognosis can be made based on a subjects inferred CNV profile. |
FILED | Thursday, August 22, 2019 |
APPL NO | 17/269983 |
CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/10 (20190201) Original (OR) Class G16B 30/00 (20190201) G16B 40/30 (20190201) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327537 | Califano et al. |
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FUNDED BY |
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APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Andrea Califano (New York, New York); Mariano Javier Alvarez (Cortlandt Manor, New York) |
ABSTRACT | Methods for determining regulon enrichment in gene expression signatures are disclosed herein. An example method can include obtaining a set of transcriptional targets of a regulon. The method can include obtaining a gene expression signature by comparing a gene expression profile of a test sample to gene expression profiles of a plurality of samples representing control phenotypes. The method can include calculating a regulon enrichment score for each regulon in the gene expression signature. The method can including determining whether a number of control samples in the control phenotypes is above a predetermined threshold to support evaluation of statistical significance using permutation analysis. The method can include, in response to determining that the number of control samples is above the predetermined threshold, calculating a significance value by comparing each regulon enrichment score to a null model. |
FILED | Friday, September 25, 2020 |
APPL NO | 17/033312 |
CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 5/20 (20190201) G16B 20/00 (20190201) G16B 20/20 (20190201) Original (OR) Class G16B 25/00 (20190201) G16B 25/10 (20190201) |
VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
US 20210321975 | Sikdar et al. |
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FUNDED BY |
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APPLICANT(S) | George Mason University (Fairfax, Virginia) |
ASSIGNEE(S) | |
INVENTOR(S) | Siddhartha Sikdar (Washginton, District of Columbia); Parag Chitnis (Burke, Virginia); Biswarup Mukherjee (Fairfax, Virginia); Joseph Majdi (Fairfax, Virginia) |
ABSTRACT | A low-power (e.g., battery-operated, etc.) wearable ultrasound system may be used to monitor the musculoskeletal function of a subject and provide information that may be used for electrical stimulation. |
FILED | Wednesday, April 21, 2021 |
APPL NO | 17/236752 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) Original (OR) Class A61B 8/488 (20130101) A61B 8/5223 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36003 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 30/40 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322025 | Greene et al. |
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FUNDED BY |
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APPLICANT(S) | MicroVention, Inc. (Tustin, California); University of Virginia Patent Foundation (Charlottesville, Virginia); United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland); Emergency Scientific LLC (Salt Lake City, Utah) |
ASSIGNEE(S) | MicroVention, Inc. (Tustin, California); University of Virginia Patent Foundation (Charlottesville, Virginia); United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland); Emergency Scientific LLC (Salt Lake City, Utah) |
INVENTOR(S) | George R. Greene (Costa Mesa, California); Ivan Sepetka (Los Altos, California); Cathy Lei (Chino Hills, California); Rupal Nguyen (Costa Mesa, California); Matthew J. Bradley (Silver Spring, Maryland); Stephen T. Ahlers (Silver Spring, Maryland); Carl S. Goforth (Silver Spring, Maryland); James R. Stone (Charlottesville, Virginia); Timothy Ray Nieman (North Salt Lake City, Utah); Shawn Fojtik (Park City, Utah) |
ABSTRACT | Blood vessel occlusion devices, systems and methods, in particular embodiments of devices for aortic occlusion. The device includes one or more locator portions and an occluder portion. The device is delivered via transcatheter delivery. The locator portion may be radially expanded using a handle and actuator at the proximal end of the delivery catheter. Tactile feedback from the locator portion is used to determine proper location of the occluder portion, for example within the abdominal aorta. The occluder is then radially expanded to occlude the vessel. |
FILED | Friday, June 25, 2021 |
APPL NO | 17/359304 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1204 (20130101) A61B 17/12109 (20130101) Original (OR) Class A61B 17/12136 (20130101) A61B 2017/1205 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/1011 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322026 | JOHNSON et al. |
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FUNDED BY |
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APPLICANT(S) | Certus Critical Care, Inc. (Sacramento, California); Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Michael Austin JOHNSON (Holladay, Utah); David POISNER (Carmichael, California); Melanie MCWADE (Portland, Oregon); Timothy WILLIAMS (Winston-Salem, North Carolina); Lucas NEFF (Winston-Salem, North Carolina) |
ABSTRACT | Systems and methods for blood flow control are described herein. In some variations, a blood flow control system may comprise a blood flow control device. The blood flow control device may be placed within a body of a patient and may comprise an expandable member and a sensor. The sensor may be configured to measure at least one of a physiologic condition of the patient and a pressure associated with the expandable member. The blood flow control system may include at least one controller communicably coupled to the sensor to: receive data indicative of at least one of the physiologic condition of the patient and the pressure associated with the expandable member from the sensor, compare the received data with target data, identify at least one error based on the comparison, and in response to identifying the error, inhibit at least one function of the blood flow control system. |
FILED | Tuesday, March 16, 2021 |
APPL NO | 17/203742 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02158 (20130101) A61B 5/4836 (20130101) A61B 17/12109 (20130101) A61B 17/12136 (20130101) Original (OR) Class A61B 34/25 (20160201) A61B 2017/00557 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322300 | CHEN et al. |
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FUNDED BY |
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APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Samson CHEN (Pasadena, California); Axel SCHERER (Pasadena, California); Richard Daniel SMITH, JR. (Pasadena, California) |
ABSTRACT | An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required. |
FILED | Friday, May 14, 2021 |
APPL NO | 17/321296 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/686 (20130101) A61B 5/4839 (20130101) A61B 5/14532 (20130101) Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/1412 (20130101) A61J 1/1468 (20150501) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) Original (OR) Class A61K 9/0024 (20130101) A61K 9/0097 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322559 | Kessler et al. |
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FUNDED BY |
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APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
ASSIGNEE(S) | |
INVENTOR(S) | Julian Kessler (Salt Lake City, Utah); Michael S. Yu (Salt Lake City, Utah); Yang Li (Salt Lake City, Utah) |
ABSTRACT | Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a dimeric collagen hybridizing peptide comprising a first and second collagen hybridizing peptide, a linker; and a branch point, wherein the first and second collagen hybridizing peptides comprise the sequence of at least (GXY)n, wherein G is glycine, wherein X and Y are any amino acid, and wherein n is any number between 3 and 12. Also disclosed are methods of detecting denatured collagen in a sample comprising contacting a composition comprising any one of the disclosed peptide conjugates to a sample, wherein the active agent comprises a therapeutic agent, and detecting the presence or absence of binding of the peptide conjugate to denatured collagen, the presence of binding indicating the presence of denatured collagen in the sample. Also disclosed are methods of treating a disease or injury involving collagen damage comprising administering to a subject having a disease or injury involving collagen damage any one of the disclosed peptide conjugates. |
FILED | Wednesday, February 24, 2021 |
APPL NO | 17/184289 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) A61K 47/65 (20170801) A61K 47/641 (20170801) Original (OR) Class Peptides C07K 14/78 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6887 (20130101) G01N 2333/78 (20130101) G01N 2500/20 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322689 | Hoekman et al. |
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FUNDED BY |
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APPLICANT(S) | Impel Neuropharma, Inc. (Seattle, Washington) |
ASSIGNEE(S) | |
INVENTOR(S) | John D. Hoekman (Seattle, Washington); Michael Hite (Normandy Park, Washington); Alan Brunelle (Woodinville, Washington); Joel Relethford (Everett, Washington) |
ABSTRACT | A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle. |
FILED | Monday, February 01, 2021 |
APPL NO | 17/164371 |
CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 15/08 (20130101) Original (OR) Class A61M 15/0021 (20140204) A61M 16/127 (20140204) A61M 16/208 (20130101) A61M 2210/0612 (20130101) A61M 2210/0618 (20130101) A61M 2210/1067 (20130101) A61M 2210/1475 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/14 (20130101) B05B 7/08 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322771 | Wagner et al. |
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FUNDED BY |
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APPLICANT(S) | Highland Instruments, Inc. (Somerville, Massachusetts) |
ASSIGNEE(S) | Highland Instruments, Inc. (Somerville, Massachusetts) |
INVENTOR(S) | Timothy Andrew Wagner (Somerville, Massachusetts); Uri Tzvi Eden (Somerville, Massachusetts) |
ABSTRACT | The invention generally relates to methods of stimulating tissue based upon filtering properties of the tissue. In certain aspects, the invention provides methods for stimulating tissue that involve analyzing at least one filtering property of a region of at least one tissue, and providing a dose of energy to the at least one region of tissue based upon results of the analyzing step. |
FILED | Monday, April 19, 2021 |
APPL NO | 17/233762 |
CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 23/0236 (20130101) A61H 23/0245 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36025 (20130101) Original (OR) Class A61N 1/36082 (20130101) A61N 5/02 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322951 | Medina et al. |
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FUNDED BY |
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APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
ASSIGNEE(S) | |
INVENTOR(S) | Victor F Medina (Clinton, Mississippi); Scott A Waisner (Vicksburg, Mississippi); Charles C Ellison (Vicksburg, Mississippi); Jose Mattei-Sosa (Vicksburg, Mississippi); Jacob M Lalley (Vicksburg, Mississippi); Christopher S Griggs (Vicksburg, Mississippi) |
ABSTRACT | In one embodiment, a system of PFAS (Per-Poly-fluorinated alkyl substances) effluent liquid treatment includes: a pump to pump a liquid received via an intake; a sediment filter to filter sediment from the liquid; a granular activated carbon (GAC) device, disposed downstream of the sediment filter, to remove organic contaminants from the liquid; one (preferably two) or more ion exchange resin columns, disposed downstream of the GAC device, to remove PFAS constituents from the liquid; and a plurality of control valves being controlled to direct the liquid to flow along one or more liquid flow paths through the ion exchange resin columns so as to adjust a rate of processing the liquid by the ion exchange resin columns. Directing the flow takes into consideration factors including any minimum rate of processing, any maximum amount of waste generation, and any target remaining PFAS contamination in the liquid after processing. |
FILED | Tuesday, April 21, 2020 |
APPL NO | 16/854874 |
CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/20 (20130101) Original (OR) Class Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/283 (20130101) C02F 2101/36 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322976 | NG Pitti et al. |
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FUNDED BY |
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APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Carlos Francisco NG Pitti (Jamaica Plain, Massachusetts); Ulri Nicole Lee (Seattle, Washington); Richard Novack (Boston, Massachusetts); Olivier Yves Frederic Henry (Brookline, Massachusetts); Remco Franciscus Peter Van Erp (Sint Anthonis, Netherlands); Donald E. Ingber (Boston, Massachusetts) |
ABSTRACT | A fluidic device includes a fluidic layer, a capture material, and an electronics layer, the fluidic layer includes a main channel and a pair of sample channels fluidly coupled to the main channel. The pair of sample channels is configured to receive and introduce a sample material into the device. The sample material includes an analyte. The capture material is positioned in a portion of the main channel that is spaced from the pair of sample channels. The capture material has a three-dimensional matrix of receptors therein configured to bond with the analyte. The capture material has a length that is associated with a dynamic range of the fluidic device and a cross-sectional area that is associated with a sensitivity of the fluidic device. The electronics layer includes electrodes configured to measure an electrical resistance through a portion of the capture material. |
FILED | Wednesday, March 14, 2018 |
APPL NO | 16/494230 |
CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) Original (OR) Class B01L 3/502715 (20130101) B01L 2300/069 (20130101) B01L 2300/0645 (20130101) B01L 2300/0867 (20130101) B01L 2300/0896 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/08 (20130101) G01N 33/48707 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323257 | O'Keefe |
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FUNDED BY |
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APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Cheryl O'Keefe (North Billerica, Massachusetts) |
ABSTRACT | Techniques are disclosed for modifying the acoustic signature of plastic structures. An example structure implementing the techniques includes an inner wall forming an inner shell of the structure, the inner wall having a first edge and a second edge opposing the first edge, and an outer wall forming an outer shell of the structure, the outer wall having a first edge and a second edge opposing the first edge. The structure also includes an upper wall member joining the first edge of the inner wall to the first edge of the outer wall and a lower wall member joining the second edge of the inner wall to the second edge of the outer wall to form a wall cavity, an infill structure within the wall cavity, and at least two holes in the structure providing an opening from an exterior of the structure to the wall cavity. |
FILED | Wednesday, March 31, 2021 |
APPL NO | 17/218835 |
CURRENT CPC | Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 99/0089 (20130101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) B33Y 80/00 (20141201) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/521 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323352 | Manesh et al. |
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FUNDED BY |
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APPLICANT(S) | Bridgestone Americas Tire Operations, LLC (Nashville, Tennessee) |
ASSIGNEE(S) | |
INVENTOR(S) | Ali Manesh (Chicago, Illinois); Mike Tercha (Weston, Wisconsin); Brian Anderson (Wausau, Wisconsin); Karen Schlei (Wausau, Wisconsin); Brian Meliska (Weston, Wisconsin); Louis Stark (Kronenwetter, Wisconsin); Benjamin Knospe (Merrill, Wisconsin); Fidelis Ceranski (Marathon, Wisconsin); Glenn Howland (Kronenwetter, Wisconsin) |
ABSTRACT | A non-pneumatic tire and hub assembly includes an inner ring having an axis of rotation, a deformable outer ring, and a flexible web extending between the inner ring and the deformable outer ring. The assembly further includes a hollow, metal cylinder coupled to the inner ring. The hollow, metal cylinder has a flanged portion extending towards an interior portion of the hollow, metal cylinder. |
FILED | Tuesday, April 20, 2021 |
APPL NO | 17/235250 |
CURRENT CPC | Vehicle Tyres Tyre Inflation; Tyre Changing or Repairing; Repairing, or Connecting Valves To, Inflatable Elastic Bodies in General; Devices or Arrangements Related to Tyres B60C 7/00 (20130101) B60C 7/14 (20130101) Original (OR) Class B60C 7/18 (20130101) B60C 7/24 (20130101) B60C 2007/107 (20130101) Technical Subjects Covered by Former US Classification Y10T 152/10378 (20150115) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323645 | Price et al. |
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FUNDED BY |
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APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
ASSIGNEE(S) | |
INVENTOR(S) | Christopher M. Price (Monterey, California); Paul R. Leary (Monterey, California); Brian S. Bingham (Pacific Grove, California) |
ABSTRACT | The invention relates to a payload frame for deploying a payload underwater. The payload frame includes at least three lead screws, each lead screw connected near a top end of the lead screw to the payload by a corresponding spherical bearing; at least three motors, each motor connected to a bottom end of one of the lead screws, the motor to rotate the lead screw through the corresponding spherical bearing; at least three feet, each foot attached to one of the motors, the feet to support and secure the payload frame on a water body bed; an accelerometer attached to the payload, the accelerometer to measure gravity vectors of the payload; and a microcontroller connected to the accelerometer and the motors. The microcontroller to receive the gravity vectors from the accelerometer and control each of the motors based on the gravity vectors to position the payload in a target orientation. |
FILED | Wednesday, April 21, 2021 |
APPL NO | 17/236975 |
CURRENT CPC | Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 8/001 (20130101) Original (OR) Class B63G 8/20 (20130101) B63G 2008/004 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323689 | Pan et al. |
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FUNDED BY |
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APPLICANT(S) | MICROLINK DEVICES, INC. (Niles, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Noren Pan (Wilmette, Illinois); Raymond Chan (Hoffman Estates, Illinois); Haruki Miyamoto (Arlington Heights, Illinois); Andree Wibowo (Itasca, Illinois); Mark Osowski (Vernon Hills, Illinois); Christopher Youtsey (Libertyville, Illinois); David McCallum (West Chicago, Illinois) |
ABSTRACT | Some embodiments include a high efficiency, lightweight solar sheet. Some embodiments include a solar sheet configured for installation on a surface of a UAV or on a surface of a component of a UAV. The solar sheet includes a plurality of solar cells and a polymer layer to which the plurality of solar cells are attached. Some embodiments include a kit for supplying solar power in a battery-powered or fuel cell powered unmanned aerial vehicle (UAV) by incorporating flexible solar cells into a component of a UAV, affixing flexible solar cells to a surface of a UAV, or affixing flexible solar cells to a surface of a component of a UAV. The kit also includes a power conditioning system configured to operate the solar cells within a desired power range and configured to provide power having a voltage compatible with an electrical system of the UAV. |
FILED | Wednesday, June 23, 2021 |
APPL NO | 17/356017 |
CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 8/003 (20130101) B60L 53/00 (20190201) B60L 2200/10 (20130101) Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/021 (20130101) B64C 2201/042 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) Original (OR) Class B64D 2221/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/046 (20141201) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/40 (20141201) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323868 | Wadley et al. |
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FUNDED BY |
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APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
INVENTOR(S) | Haydn N. G. Wadley (Keswick, Virginia); Jeroen A. Deijkers (Charlottesville, Virginia) |
ABSTRACT | A new class of multi-component rare earth multi-silicate materials has been created for use in harsh environments such as gas turbine engines. Moreover, by combining two-or-more rare earth disilicates the properties (for example, thermal expansion, thermal conductivity, etc.) can be tailored to fit specific applications, such as having a matching thermal expansion with that of silicon-based composites and a low thermal conductivity close to that of 1 W/m K. Applications can be extended for use with other material classes such as MCrAlY, MAX-phase, and refractory metal alloys, utilizing a thermal expansion of up to about 15−10−6 /° C. By mixing of specific sets of rare earth disilicates it is possible to obtain a high entropy or entropy stabilized mixture, and utilize features such as “sluggish diffusion”, and more. |
FILED | Thursday, August 29, 2019 |
APPL NO | 17/271773 |
CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 28/006 (20130101) Original (OR) Class C04B 41/009 (20130101) C04B 41/87 (20130101) C04B 41/89 (20130101) C04B 41/522 (20130101) C04B 41/5024 (20130101) C04B 2111/00482 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/288 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/04067 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324010 | Tsao et al. |
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FUNDED BY |
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APPLICANT(S) | University of Washington (Seattle, Washington) |
ASSIGNEE(S) | University of Washington (Seattle, Washington) |
INVENTOR(S) | Caroline Tsao (Seattle, Washington); Sijin Luozhong (Seattle, Washington); Trevor Corrigan (Seattle, Washington); Shaoyi Jiang (Seattle, Washington); Erik Liu (Seattle, Washington); Patrick McMullen (Seattle, Washington) |
ABSTRACT | Charged polypeptides, their conjugates, and fusion proteins comprising such polypeptides are disclosed. Inclusion of such a polypeptide in a fusion protein increases the protein's properties such as stability and circulation half-life, which results in a better therapeutic efficacy compared to an active protein alone. Thus, a fusion protein or a conjugate of the disclosure can be useful in developing a protein or peptide drug, treating or preventing diseases, disorders, or conditions, or improving a subjects health or wellbeing. |
FILED | Thursday, October 10, 2019 |
APPL NO | 17/283708 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/645 (20170801) Peptides C07K 14/00 (20130101) Original (OR) Class C07K 14/56 (20130101) C07K 14/535 (20130101) C07K 14/43595 (20130101) C07K 2319/00 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324011 | SHEN et al. |
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FUNDED BY |
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APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
ASSIGNEE(S) | |
INVENTOR(S) | Hao SHEN (Seattle, Washington); Jorge FALLAS (Seattle, Washington); David BAKER (Seattle, Washington) |
ABSTRACT | Disclosed herein are polypeptides having the amino acid sequence that is at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the full length of the amino acid sequence selected from the group consisting of SEQ ID NO: 1-33 and 36, wherein the polypeptides include at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of the identified interface residues, and wherein the polypeptides are capable of end-to-end homo-polymerization, homo-polymers of the polypeptides, and related capping and anchor proteins to facilitate homo-polymer formation. |
FILED | Thursday, October 24, 2019 |
APPL NO | 17/285057 |
CURRENT CPC | Peptides C07K 1/00 (20130101) C07K 14/001 (20130101) Original (OR) Class C07K 2319/00 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324051 | CROWE, Jr. et al. |
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FUNDED BY |
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APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
ASSIGNEE(S) | |
INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee); Andrew I. FLYAK (Nashville, Tennessee); Alexander BUKREYEV (Galveston, Texas); Philipp ILINYKH (Galveston, Texas) |
ABSTRACT | The present disclosure is directed to antibodies binding to Marburg virus (MARV) glycoprotein (GP) and methods of use therefore. |
FILED | Thursday, July 01, 2021 |
APPL NO | 17/365429 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 16/468 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324071 | COOPER et al. |
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FUNDED BY |
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APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Cambridge, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Laurence J.N. COOPER (Houston, Texas); Ana Beatriz KORNGOLD (Houston, Texas); Brian A. RABINOVICH (Houston, Texas); Harjeet SINGH (Houston, Texas); Simon OLIVARES (Houston, Texas) |
ABSTRACT | Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon. |
FILED | Friday, February 26, 2021 |
APPL NO | 17/187074 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2035/124 (20130101) Peptides C07K 14/4746 (20130101) C07K 14/4748 (20130101) C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 2317/622 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) C12N 15/85 (20130101) Enzymes C12Y 207/07 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324121 | Liebfarth et al. |
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FUNDED BY |
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APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Frank Liebfarth (Carrboro, North Carolina); Aaron Teator (Chapel Hill, North Carolina) |
ABSTRACT | Disclosed herein are isotactic polyvinyl ethers and improved methods of making same. The method disclosed herein can produce polyvinyl ethers having a higher isotacticity as compared to polyvinyl ethers prepared with conventional methods. |
FILED | Thursday, August 15, 2019 |
APPL NO | 17/269247 |
CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 216/20 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324205 | Walters et al. |
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FUNDED BY |
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APPLICANT(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
INVENTOR(S) | David N. Walters (Slippery Rock, Pennsylvania); John R. Schneider (Sharpsburg, Pennsylvania) |
ABSTRACT | Coating compositions are disclosed that include corrosion resisting particles such that the coating composition can exhibit corrosion resistance properties. Also disclosed are substrates at least partially coated with a coating deposited from such a composition and multi-component composite coatings, wherein at least one coating later is deposited from such a coating composition. Methods and apparatus for making ultrafine solid particles are also disclosed. |
FILED | Wednesday, April 21, 2021 |
APPL NO | 17/236576 |
CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 283/006 (20130101) C08F 290/06 (20130101) C08F 299/06 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/672 (20130101) C08G 18/3206 (20130101) Compositions of Macromolecular Compounds C08L 23/26 (20130101) C08L 27/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 4/06 (20130101) C09D 5/002 (20130101) C09D 5/084 (20130101) Original (OR) Class C09D 7/67 (20180101) C09D 123/26 (20130101) C09D 175/16 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/258 (20150115) Y10T 428/31522 (20150401) Y10T 428/31529 (20150401) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324269 | Boyd et al. |
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FUNDED BY |
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APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
INVENTOR(S) | Darryl A. Boyd (Alexandria, Virginia); Michael H. Stewart (Springfield, Virginia); Kimihiro Susumu (Alexandria, Virginia); Eunkeu Oh (Alexandria, Virginia); James P. Wissman (Hyattsville, Maryland) |
ABSTRACT | This disclosure concerns a method of making a ligand for Quantum Dot functionalization, a method of making a functionalized Quantum Dot (QD) with a ligand, and a method of making a transparent luminescent quantum dot thiol-yne nanocomposite with tailorable optical, thermal, and mechanical properties. The prepolymer solution and functionalized Quantum Dot can be used in additive manufacturing. |
FILED | Wednesday, June 30, 2021 |
APPL NO | 17/363526 |
CURRENT CPC | Heterocyclic Compounds C07D 339/04 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/02 (20130101) C09K 11/886 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324311 | Skardal et al. |
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APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Aleksander Skardal (Clemmons, North Carolina); Thomas Shupe (Mocksville, North Carolina); Anthony Atala (Winston-Salem, North Carolina) |
ABSTRACT | Described herein are apparatus, including multi-tissue body-on-a-chip apparatus. In some embodiments, described are apparatus including at least a first, second, and third chamber in fluid communication with one another and with at least one tissue in each chamber, such as, for example, liver tissue in said first chamber; cardiac muscle tissue in said second chamber; and lung tissue in said third chamber; and a common aqueous growth media in said first, second, and third chamber. In some embodiments, the apparatus includes a fourth chamber including testicular or ovarian tissue in said fourth chamber. In some embodiments, the apparatus includes an optional fifth or sixth chamber; each said chamber includes different additional tissue selected from the group consisting of vascular endothelial, skeletal muscle, kidney, nerve, brain, and intestinal tissue (e.g., small intestine tissue and/or colon tissue). Also described are methods of using an apparatus of the present invention. |
FILED | Tuesday, October 10, 2017 |
APPL NO | 16/341521 |
CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 23/44 (20130101) C12M 29/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5082 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324357 | CHOUDHARY et al. |
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APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (BOSTON, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Amit CHOUDHARY (Boston, Massachusetts); Qingxuan ZHOU (BOSTON, Massachusetts); Praveen KOKKONDA (BOSTON, Massachusetts) |
ABSTRACT | The disclosure includes non-naturally occurring or engineered CRISPR Cas variant proteins comprising one or more functional domains and degrader compositions specifically targeting the CRISPR Cas variant proteins; compositions, systems and methods of using the CRISPR Cas variant proteins comprising one or more functional domains and degrader compounds for spatio-temporal control are also provided. |
FILED | Tuesday, August 20, 2019 |
APPL NO | 17/270358 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/506 (20130101) A61K 31/7088 (20130101) A61K 38/465 (20130101) A61K 48/00 (20130101) Peptides C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324382 | Jakimo et al. |
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FUNDED BY |
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APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
INVENTOR(S) | Noah Jakimo (Boston, Massachusetts); Pranam Chatterjee (Cambridge, Massachusetts); Joseph M. Jacobson (Newton, Massachusetts) |
ABSTRACT | A chimeric DNA:RNA guide for very high accuracy Cas9 genome editing employs nucleotide-type substitutions in nucleic acid-guided endonucleases for enhanced specificity. The CRISPR-Cas9 gene editing system is manipulated to generate chimeric DNA:RNA guide strands to minimize the off-target cleavage events of the S. pyogenes Cas9 endonuclease. A DNA:RNA chimeric guide strand is sufficient to guide Cas9 to a specified target sequence for indel formation and minimize off-target cleavage events due to the specificity conferred by DNA-DNA interactions. Use of chimeric mismatch-evading lowered-thermostability guides (“melt-guides”) demonstrate that nucleotide-type substitutions in the spacer can reduce cleavage of sequences mismatched by as few as a single base pair. The chimeric mismatch-evading lowered-thermostability guides replace most gRNA spacer positions with DNA bases to suppress mismatched targets under Cas9's catalytic threshold. |
FILED | Friday, January 22, 2021 |
APPL NO | 17/156492 |
CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/111 (20130101) C12N 15/907 (20130101) C12N 15/1136 (20130101) C12N 2310/20 (20170501) C12N 2310/335 (20130101) C12N 2310/343 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324389 | Abedi et al. |
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FUNDED BY |
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APPLICANT(S) | California Institute of Technology (Pasadena, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Mohamad H. Abedi (Pasadena, California); Mikhail Shapiro (Pasadena, California); Dan I. Piraner (Pasadena, California); Justin Lee (Pasadena, California) |
ABSTRACT | Disclosed herein include methods, compositions, and kits suitable for use in spatiotemporal regulation of therapeutic T-cells through a combination of molecular and physical actuation. There are provided, in some embodiments, thermal bioswitches that allow T-cells to sense small changes in temperature and use them as inputs for the actuation of genetic circuits. Also disclosed herein are T cell activity sensors. Genetic circuits capable of inducing expression of a payload upon thermal stimulation and/or immune cell stimulation are provided. There are provided, in some embodiments, thermally actuated immune cells and methods of using are provided. Oscillator circuits and methods of preventing T cell exhaustion are also disclosed. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/230998 |
CURRENT CPC | Peptides C07K 14/7051 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/635 (20130101) Original (OR) Class C12N 2830/008 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324512 | Wu et al. |
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APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
ASSIGNEE(S) | |
INVENTOR(S) | Judy Z. Wu (Lawrence, Kansas); Qingfeng Liu (Nanjing, China PRC) |
ABSTRACT | A method of making a plasmonic metal/graphene heterostructure comprises heating an organometallic complex precursor comprising a metal at a first temperature T1 for a first period of time t1 to deposit a layer of the metal on a surface of a heated substrate, the heated substrate in fluid communication with the precursor; and heating, in situ, the precursor at a second temperature T2 for a second period of time t2 to simultaneously form on the layer of the metal, a monolayer of graphene and a plurality of carbon-encapsulated metal nanostructures comprising the metal, thereby providing the plasmonic metal/graphene heterostructure. The heated substrate is characterized by a third temperature T3. The plasmonic metal/graphene heterostructures, devices incorporating the heterostructures, and methods of using the heterostructures are also provided. |
FILED | Wednesday, July 03, 2019 |
APPL NO | 17/255817 |
CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/30 (20130101) Original (OR) Class C23C 16/448 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/028 (20130101) H01L 31/0232 (20130101) H01L 31/02161 (20130101) H01L 31/02363 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325303 | Ancona et al. |
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APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
ASSIGNEE(S) | |
INVENTOR(S) | Mario Ancona (Alexandria, Virginia); Hieu Bui (Alexandria, Virginia) |
ABSTRACT | The stiffness and topology of ultra-small circular DNAs and DNA/peptide hybrids are exploited to create a transducer of enzyme activity with low error rates. The modularity and flexibility of the concept are illustrated by demonstrating various transducers that respond to either specific restriction endonucleases or to specific proteases. In all cases the output is a DNA oligo signal that, as we show, can readily be converted directly to an optical readout, or can serve as input for further processing, for example, using DNA logic or amplification. By exploiting the DNA hairpin (or stem-loop) structure and the phenomenon of strand displacement, an enzyme signal is converted into a DNA signal, in the manner of a transducer. This is valuable because a DNA signal can be readily amplified, combined, and processed as information. |
FILED | Wednesday, June 16, 2021 |
APPL NO | 17/348824 |
CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) Original (OR) Class G01N 33/52 (20130101) G01N 33/542 (20130101) G01N 2021/6432 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325333 | Glaven et al. |
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FUNDED BY |
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APPLICANT(S) | The Government of the United States of Amerrica, as represented by the Secretary of the Navy (Arlington, Virginia) |
ASSIGNEE(S) | |
INVENTOR(S) | Sarah M. Glaven (Washington, District of Columbia); Daniel A. Phillips (Washington, District of Columbia); Matthew D. Yates (Washington, District of Columbia); Leonard M. Tender (Bethesda, Maryland) |
ABSTRACT | A biocompatible electrochemical flow cell (eFC) for high resolution imaging of anode and cathode biofilms using laser scanning confocal microscopy employs optically transparent indium tin oxide (ITO)-coated electrode configured to allow observation of the flow chamber. This enables correlation of electrochemical signatures with biofilm development in real-time. |
FILED | Monday, April 19, 2021 |
APPL NO | 17/233617 |
CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/48 (20130101) G01N 27/327 (20130101) Original (OR) Class G01N 27/4161 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325355 | Rubenstein et al. |
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APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
INVENTOR(S) | Mitchell H. Rubenstein (Beavercreek, Ohio); Patrick Lewis (Alburquerque, New Mexico) |
ABSTRACT | A system for solventless calibration of volatile or semi-volatile compounds and methods thereof. The system includes a fluid path having a first end configured to be operably coupled to a fluid source and a second end configured to be operably coupled to the analytical instrument. A solid sorbent is disposed along the fluid path and is configured to absorb an analyte. The flow of fluid along the fluid path from the first end to the second end causes absorbed analyte to be desorbed from the solid sorbent at a desired concentration to the instrument. |
FILED | Thursday, June 24, 2021 |
APPL NO | 17/356822 |
CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) B01J 20/262 (20130101) B01J 2220/54 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/12 (20130101) G01N 30/93 (20130101) G01N 30/482 (20130101) G01N 30/8665 (20130101) Original (OR) Class G01N 2030/328 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325553 | HAMEED et al. |
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FUNDED BY |
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APPLICANT(S) | The United States of America, as represnted by the Secratray of the Navy (Arlington, Virginia) |
ASSIGNEE(S) | |
INVENTOR(S) | Zishan HAMEED (Norfolk, Virginia); John GATS (Seattle, Washington); Jin-Woo HAN (San Jose, California); Meyya Meyyappan (San Jose, California) |
ABSTRACT | A MEMS nanotube based radiation sensor that is low cost, low power, compact, reliable and is applicable across many fields and a method for fabricating such a sensor are described. Each sensor may be connected to an array of similar but distinct sensors that leverage different materials and nanotube technology to detect radiation. |
FILED | Saturday, April 17, 2021 |
APPL NO | 17/233441 |
CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 7/0058 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Measurement of Nuclear or X-radiation G01T 3/08 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325577 | Kildishev et al. |
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FUNDED BY |
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APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
INVENTOR(S) | Alexander V. Kildishev (West Lafayette, Indiana); Di Wang (West Lafayette, Indiana); Zhaxylyk A. Kudyshev (West Lafayette, Indiana); Maowen Song (West Lafayette, Indiana); Alexandra Boltasseva (West Lafayette, Indiana); Vladimir M. Shalaev (West Lafayette, Indiana) |
ABSTRACT | A plasmonic system is disclosed. The system includes at least one polarizer that is configured to provide at least one linearly polarized broadband light beam, an anisotropic plasmonic metasurface (APM) assembly having a plurality of nanoantennae each having a predetermined orientation with respect to a global axis representing encoded digital data, the APM assembly configured to receive the at least one linearly polarized broadband light beam and by applying localized surface plasmon resonance reflect light with selectable wavelengths associated with the predetermined orientations of the nanoantennae, and at least one analyzer that is configured to receive the reflected light with selectable wavelength, wherein the relative angles between each of the at least one analyzers and each of the at least one polarizers are selectable with respect to the global axis, thereby allowing decoding of the digital data. |
FILED | Wednesday, April 07, 2021 |
APPL NO | 17/224338 |
CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) Original (OR) Class Information Storage Based on Relative Movement Between Record Carrier and Transducer G11B 7/125 (20130101) G11B 7/1381 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325656 | Liu et al. |
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FUNDED BY |
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APPLICANT(S) | University of Washington (Seattle, Washington) |
ASSIGNEE(S) | University of Washington (Seattle, Washington) |
INVENTOR(S) | Jonathan T.C. Liu (Seattle, Washington); Lindsey A. Barner (Seattle, Washington); Adam K. Glaser (Seattle, Washington) |
ABSTRACT | Apparatuses, systems, and methods for solid immersion meniscus lenses (SIMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices. |
FILED | Wednesday, June 23, 2021 |
APPL NO | 17/356135 |
CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/0032 (20130101) G02B 21/33 (20130101) Original (OR) Class G02B 21/248 (20130101) G02B 21/367 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325952 | Ardanaz et al. |
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FUNDED BY |
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APPLICANT(S) | INTEL CORPORATION (Santa Clara, California) |
ASSIGNEE(S) | INTEL CORPORATION (SANTA CLARA, California) |
INVENTOR(S) | Federico Ardanaz (Hillsboro, Oregon); Jonathan M. Eastep (Portland, Oregon); Richard J. Greco (West Linn, Oregon); Ramkumar Nagappan (Chandler, Arizona); Alan B. Kyker (Winters, California) |
ABSTRACT | Apparatus, systems, and methods provide an interface between a plurality of hardware resources of a node and a power manager. The interface is configured to define one or more resource groups to expose to the power manager for power measurement and control, assign the plurality of hardware resources to the one or more resource groups, and provide a power allowance to each resource group. |
FILED | Thursday, June 24, 2021 |
APPL NO | 17/357479 |
CURRENT CPC | Electric Digital Data Processing G06F 1/325 (20130101) Original (OR) Class G06F 1/3287 (20130101) G06F 1/3293 (20130101) Climate Change Mitigation Technologies in Information and Communication Technologies [ICT] i.e Information and Communication Technologies Aiming at the Reduction of Their Own Energy Use Y02D 10/00 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210326464 | ZHU |
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APPLICANT(S) | NIRA, INC. (McLean, Virginia) |
ASSIGNEE(S) | |
INVENTOR(S) | Wen ZHU (McLean, Virginia) |
ABSTRACT | A method for document authorization and distribution is provided. The method is based on a system including a repository server, communicating with or hosting a repository; a blockchain network, including a plurality of peers; and a plurality of user devices, each communicating with the repository server or the blockchain network. The repository contains a plurality of published documents. A plurality of document publication records, a plurality of document dissemination records, and an access control smart contract are distributed over the peers. The method includes: when an access request for a published document is submitted by a user from a user device, retrieving the published document; verifying the document access right; encrypting the published document with a document password encrypted using the user's public key; signing and posting a document dissemination record, including the document password; and placing the document contents and a signed document hash value in a container document. |
FILED | Tuesday, April 21, 2020 |
APPL NO | 16/854685 |
CURRENT CPC | Electric Digital Data Processing G06F 16/93 (20190101) G06F 16/954 (20190101) G06F 21/602 (20130101) G06F 21/6209 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210326664 | Dasgupta et al. |
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FUNDED BY |
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APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
ASSIGNEE(S) | |
INVENTOR(S) | Prithviraj Dasgupta (Springfield, Virginia); Joseph B. Collins (McLean, Virginia) |
ABSTRACT | Methods and systems are provided for automatic classification of information in an adversarial machine learning setting. For example, a learner that includes multiple classifiers may perform data classification automatically. Each classifier may be trained with adversarial data of a different strength. For a given query to be classified, the learner is configured to intelligently select a classifier that is commensurate with the adversarial strength of the data inside the query, without explicit knowledge of that data or its adversarial strength. |
FILED | Monday, March 01, 2021 |
APPL NO | 17/188923 |
CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/628 (20130101) G06K 9/6278 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/20 (20190101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210326704 | George |
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APPLICANT(S) | UNIVERISTY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
ASSIGNEE(S) | |
INVENTOR(S) | Jacob Anthony George (Salt Lake City, Utah) |
ABSTRACT | A method for training an artificial intelligence (AI) model for allowing a user to intuitively control an electronic device includes positioning a plurality of sensors at a plurality of particular positions on a human body for sensing electric signals. The method also includes recording a first set of electric signals from each of the plurality of sensors in a continuous manner. At the same time, a first set of motion intents associated with a first sequence of body movement is also recorded in a continuous manner. An AI regression model is trained using a neural network to map the first set of electric signals to the first set of motion intents. In response to receiving a second set of electric signals from the plurality of sensors in a continuous manner, the AI regression model predicts a motion intent, causing the electronic device to perform an action. |
FILED | Wednesday, April 14, 2021 |
APPL NO | 17/230446 |
CURRENT CPC | Electric Digital Data Processing G06F 3/014 (20130101) G06F 3/015 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Original (OR) Class G06N 3/063 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210326756 | Khaleghi et al. |
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FUNDED BY |
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APPLICANT(S) | The Regents of the University of California (Oakland, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Behnam Khaleghi (La Jolla, California); Tajana Simunic Rosing (San Diego, California); Mohsen Imani (San Diego, California); Sahand Salamat (San Diego, California) |
ABSTRACT | A method of providing a trained machine learning model can include providing a trained non-binary hyperdimensional machine learning model that includes a plurality of trained hypervector classes, wherein each of the trained hypervector classes includes N elements, and then, eliminating selected ones of the N elements from the trained non-binary hyperdimensional machine learning model based on whether the selected element has a similarity with other ones of the N elements, to provide a sparsified trained non-binary hyperdimensional machine learning model. |
FILED | Wednesday, April 07, 2021 |
APPL NO | 17/224306 |
CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/628 (20130101) G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327061 | Clymer et al. |
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APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania); UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
ASSIGNEE(S) | |
INVENTOR(S) | Daniel Clymer (Pittsburgh, Pennsylvania); Jonathan Cagan (Pittsburgh, Pennsylvania); Philip LeDuc (Pittsburgh, Pennsylvania); Liron Pantanowitz (Pittsburgh, Pennsylvania); Janet Catov (Pittsburgh, Pennsylvania) |
ABSTRACT | A hierarchical deep-learning object detection framework provides a method for identifying objects of interest in high-resolution, high pixel count images, wherein the objects of interest comprise a relatively a small pixel count when compared to the overall image. The method uses first deep-learning model to analyze the high pixel count images, in whole or as a patchwork, at a lower resolution to identify objects, and a second deep-learning model to analyze the objects at a higher resolution to classify the objects. |
FILED | Friday, May 21, 2021 |
APPL NO | 17/326541 |
CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6247 (20130101) G06K 9/6268 (20130101) G06K 2209/051 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/20021 (20130101) G06T 2207/20081 (20130101) G06T 2207/30101 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327403 | Huang et al. |
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APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
ASSIGNEE(S) | |
INVENTOR(S) | Guoliang Huang (Columbia, Missouri); Yangyang Chen (Columbia, Missouri); Xiaopeng Li (Columbia, Missouri) |
ABSTRACT | A programmable metasurface and method is described having a plurality of parallel slits in an elastic substrate plate defining a plurality of unit cells, each having an actuator beam and a sensing beam with a slit therebetween. Each sensing beam has a pair of sensors for sensing flexural waves in the substrate. The actuator beam has a piezoelectric actuator that is controlled by a control circuit where the control circuit generates an actuator signal and where the control circuit compares the preceding actuator signal to the difference between the sensors and an electrical transfer function to result in the metasurface being able to perform a desired function. |
FILED | Monday, September 16, 2019 |
APPL NO | 17/262475 |
CURRENT CPC | Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/346 (20130101) Original (OR) Class G10K 11/348 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327486 | van 't Erve et al. |
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FUNDED BY |
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APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
INVENTOR(S) | Olaf M.J. van 't Erve (Falls Church, Virginia); Steven P. Bennett (Alexandria, Virginia); Adam L. Friedman (Silver Spring, Maryland) |
ABSTRACT | A metamagnetic tunneling-based spin valve device for multistate magnetic memory comprising an electronic memory logic element with four stable resistance states. A metamagnetic tunneling-based spin valve device for multistate magnetic memory comprising a layer of a metamagnetic material, a layer of a nonmagnetic material on the layer of a metamagnetic material, and a layer of a ferromagnetic material on the layer of a nonmagnetic material. A method of making a metamagnetic tunneling-based spin valve device for multistate magnetic memory. |
FILED | Tuesday, June 29, 2021 |
APPL NO | 17/362355 |
CURRENT CPC | Static Stores G11C 11/161 (20130101) Original (OR) Class G11C 11/5607 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 43/08 (20130101) H01L 43/10 (20130101) H01L 43/12 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327496 | Snider et al. |
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FUNDED BY |
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APPLICANT(S) | Indiana Integrated Circuits, LLC (South Bend, Indiana); University of Notre Dame du Lac (Notre Dame, Indiana) |
ASSIGNEE(S) | |
INVENTOR(S) | Gregory Snider (Niles, Michigan); Rene Celis-Cordova (South Bend, Indiana); Alexei Orlov (South Bend, Indiana); Tian Lu (Osceola, Indiana); Jason M. Kulick (South Bend, Indiana) |
ABSTRACT | In a method computer storage element operation, first and second rising (or falling) clock edges are applied to first and second power inputs of the computer storage element having a transistor array between the first and second power inputs over time T1 whereupon a logic value applied to an input of the transistor array is stored therein. Thereafter, first and second falling (or rising) clock edges are applied to the first and second power inputs over time T2, whereupon part of an electrical charge or energy associated with the logic value stored in the transistor array is provided to circuitry that generates the first and/or second clock edge(s), wherein the value(s) of time T1 and/or time T2 is/are greater than a product of RC, where R is resistance associated with the computer storage element, and C is a load capacitance associated with the computer storage element. |
FILED | Friday, February 19, 2021 |
APPL NO | 17/179478 |
CURRENT CPC | Static Stores G11C 11/412 (20130101) Original (OR) Class Pulse Technique H03K 3/0372 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327540 | Schobel et al. |
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FUNDED BY |
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APPLICANT(S) | Henry M. Jackson Foundation for the Advancement of Military Medicine (Bethesda, Maryland); Naval Medical Research Center (Silver Spring, Maryland); Duke University Medical Center (Durham, North Carolina); Emory University (Atlanta, Georgia) |
ASSIGNEE(S) | Henry M. Jackson Foundation for the Advancement of Military Medicine (Bethesda, Maryland); Naval Medical Research Center (Silver Spring, Maryland); Duke University Medical Center (Durham, North Carolina); Emory University (Atlanta, Georgia) |
INVENTOR(S) | Seth A Schobel (Bethesda, Maryland); Vivek Khatri (Bethesda, Maryland); Felipe Lisboa (Bethesda, Maryland); Matthew J. Bradley (Silver Spring, Maryland); Christopher J. Dente (Atlanta, Georgia); Timothy Buchman (Atlanta, Georgia); Allan D. Kirk (Durham, North Carolina); Jonathan A. Forsberg (Silver Spring, Maryland); Todd V. Brennan (Durham, North Carolina); Eric A. Elster (Bethesda, Maryland) |
ABSTRACT | The present disclosure describes methods and systems for predicting if a subject has an increased risk of having or developing one or more clinical outcomes, including prior to the detection of symptoms thereof and/or prior to onset of any detectable symptoms thereof. The present disclosure also describes a method of generating a model for predicting one or more clinical outcomes. |
FILED | Friday, August 16, 2019 |
APPL NO | 17/268882 |
CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) G16B 40/00 (20190201) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 10/60 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) G16H 70/20 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327604 | Russo et al. |
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FUNDED BY |
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APPLICANT(S) | U.S. DEVCOM Army Research Laboratory (Adelphi, Maryland) |
ASSIGNEE(S) | |
INVENTOR(S) | John A. Russo (Spencerville, Maryland); Marc S. Litz (Columbia, Maryland); William B. Ray, II (Lubbock, Texas) |
ABSTRACT | An electrode for beta-photovoltaic cells includes: a substrate formed of a conductive layer with a thickness ranging between about 10 nm to 1 micron; a composite layer of radioluminescent phosphor with radioisotope particles homogeneously dispersed therein formed on conductive substrate with a thickness ranging between about 1 and 25 microns; and a semiconductor comprising a P-i-N/P-u-N junction or a N-i-P-P junction. The radioisotope may be a beta-emitter, such as Ni-63, H-3, Pm-147, or Sr-90/Y-90. |
FILED | Wednesday, June 30, 2021 |
APPL NO | 17/363886 |
CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/02 (20130101) C25D 13/22 (20130101) Obtaining Energy From Radioactive Sources; Applications of Radiation From Radioactive Sources, Not Otherwise Provided For; Utilising Cosmic Radiation G21H 3/02 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/055 (20130101) H01L 31/075 (20130101) H01L 31/1884 (20130101) H01L 31/03046 (20130101) H01L 31/03048 (20130101) H01L 31/022475 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327694 | Houlahan, JR. et al. |
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FUNDED BY |
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APPLICANT(S) | Starfire Industries LLC (Champaign, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Thomas J. Houlahan, JR. (Urbana, Illinois); Daniel P. Menet (Urbana, Illinois); Ian F. Haehnlein (Champaign, Illinois); Ivan A. Shchelkanov (Pleasanton, California); Robert A. Stubbers (Savoy, Illinois); Brian E. Jurczyk (Champaign, Illinois) |
ABSTRACT | A system and associated method are described for depositing high-quality films for providing a coating on a three-dimensional surface such as an internal surface of a bellows structure. The system includes a magnetic array comprising multiple sets of magnets arranged to have Hall-Effect regions that run lengthwise along a sputter target. The system further includes an elongated sputtering electrode material tube surrounding the magnetic array comprising multiple sets of magnets arranged to have Hall-Effect regions that run lengthwise along the sputter target. During operation, the system generates and controls ion flux for direct current high-power impulse magnetron sputtering. During operation logic circuitry issues a control signal to control a kick pulse property of a sustained positive voltage kick pulse taken from the group consisting of: onset delay, amplitude and duration. |
FILED | Monday, May 17, 2021 |
APPL NO | 17/322600 |
CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/35 (20130101) C23C 14/3485 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/3405 (20130101) H01J 37/3417 (20130101) H01J 37/3467 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328087 | BURGER et al. |
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FUNDED BY |
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APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
INVENTOR(S) | Tobias BURGER (Ann Arbor, Michigan); Byungjun LEE (Ann Arbor, Michigan); Dejiu FAN (Ann Arbor, Michigan); Andrej LENERT (Ann Arbor, Michigan); Stephen R. FORREST (Ann Arbor, Michigan) |
ABSTRACT | To reach high efficiencies, thermophotovoltaic cells must utilize the broad spectrum of a radiative thermal source. One promising approach to overcome this challenge is to have low-energy photons reflected and reabsorbed by the thermal emitter, where their energy can have another chance at contributing toward photogeneration in the cell. However, current methods for photon recuperation are limited by insufficient bandwidth or parasitic absorption, resulting in large efficiency losses relative to theoretical limits. This work demonstrates nearly perfect reflection of low-energy photons (˜99%) by embedding an air layer within the TPV cell. This result represents a four-fold reduction in parasitic absorption relative to existing TPV cells. As out-of-band reflectance approaches unity, TPV efficiency becomes nearly insensitive to cell bandgap and emitter temperature. Accessing this regime unlocks a range of possible materials and heat sources that were previously inaccessible to TPV energy conversion. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/232243 |
CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/04 (20130101) C30B 25/22 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0005 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/043 (20141201) H01L 31/0264 (20130101) H01L 31/0687 (20130101) Original (OR) Class H01L 31/0735 (20130101) H01L 31/1852 (20130101) H01L 31/1896 (20130101) H01L 31/02327 (20130101) H01L 33/0093 (20200501) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328093 | Pan et al. |
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FUNDED BY |
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APPLICANT(S) | MICROLINK DEVICES, INC. (Niles, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Noren Pan (Wilmette, Illinois); Glen Hillier (Spring Grove, Illinois); Duy Phach Vu (San Jose, California); Rao Tatavarti (Mount Prospect, Illinois); Christopher Youtsey (Libertyville, Illinois); David McCallum (West Chicago, Illinois); Genevieve Martin (Chicago, Illinois) |
ABSTRACT | The present invention utilizes epitaxial lift-off in which a sacrificial layer is included in the epitaxial growth between the substrate and a thin film III-V compound solar cell. To provide support for the thin film III-V compound solar cell in absence of the substrate, a backing layer is applied to a surface of the thin film III-V compound solar cell before it is separated from the substrate. To separate the thin film III-V compound solar cell from the substrate, the sacrificial layer is removed as part of the epitaxial lift-off. Once the substrate is separated from the thin film III-V compound solar cell, the substrate may then be reused in the formation of another thin film III-V compound solar cell. |
FILED | Monday, February 08, 2021 |
APPL NO | 17/170133 |
CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1844 (20130101) H01L 31/1852 (20130101) Original (OR) Class H01L 31/1896 (20130101) H01L 31/06875 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328207 | Eskra et al. |
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FUNDED BY |
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APPLICANT(S) | Eskra Technical Products, Inc. (Saukville, Wisconsin) |
ASSIGNEE(S) | |
INVENTOR(S) | Michael David Eskra (Saukville, Wisconsin); Paula Margaret Ralston (Frederick, Maryland); Rodney Mortensen LaFollette (South Jordan, Utah); James Bernard Nowakowski (Washburn, Wisconsin) |
ABSTRACT | A solventless system for fabricating electrodes includes a mechanism for feeding a substrate through the system, a first application region comprised of a first device for applying a first layer to the substrate, wherein the first layer is comprised of an active material mixture and a binder, and the binder includes at least one of a thermoplastic material and a thermoset material, and the system includes a first heater positioned to heat the first layer. |
FILED | Monday, May 17, 2021 |
APPL NO | 17/302944 |
CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0404 (20130101) Original (OR) Class H01M 4/0419 (20130101) H01M 4/622 (20130101) H01M 4/623 (20130101) H01M 4/625 (20130101) H01M 4/1391 (20130101) H01M 4/1393 (20130101) H01M 4/1395 (20130101) H01M 10/0565 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328253 | Zhang et al. |
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FUNDED BY |
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APPLICANT(S) | Navitas Systems, LLC (Lisle, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Pu Zhang (Ann Arbor, Michigan); Michael Wixom (Ann Arbor, Michigan); Qingliu Wu (Ann Arbor, Michigan) |
ABSTRACT | Provided are electrode active materials with a porous structure and including a metal, that when loaded with sulfur serve as electrochemically superior cathode active materials. The metal structures are optionally used on their own, are coated with another material, or coats another porous structure such as a porous carbon structure that allows for excellent retention of both sulfur and polysulfides, are conductive themselves, and show long term stability and excellent cycle life. |
FILED | Monday, June 28, 2021 |
APPL NO | 17/360687 |
CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/38 (20130101) H01M 4/134 (20130101) H01M 4/0402 (20130101) H01M 4/624 (20130101) H01M 4/625 (20130101) H01M 4/663 (20130101) H01M 4/808 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) Original (OR) Class H01M 2004/027 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328323 | Kho et al. |
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FUNDED BY |
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APPLICANT(S) | United States Government as represented by the Secretary of the Navy (San Diego, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Yong An Kho (Chula Vista, California); Steven E. Mancewicz (San Diego, California) |
ABSTRACT | A planar antenna clamp system comprising: a base; a connector mounted to the base; a clamp arm mounted to the base such that, when in an open configuration, an air gap exists between the top surface of the base and the bottom surface of the clamp arm's distal end, and wherein the clamp arm and the base are oriented with respect to one another such that conductors of a planar antenna may be positioned in the air gap when in the open configuration; a matching circuit disposed on the top surface of the base and electrically connected to the connector; and a clamp configured to compress the conductors of the planar antenna between the top surface of the base and the bottom surface of the clamp arm such that the conductors of the planar antenna are operatively coupled with the matching circuit, when in a closed configuration. |
FILED | Friday, April 17, 2020 |
APPL NO | 16/851554 |
CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/1235 (20130101) Original (OR) Class H01Q 9/045 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328768 | Ganje et al. |
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FUNDED BY |
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APPLICANT(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
ASSIGNEE(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
INVENTOR(S) | Stephen A. Ganje (Frisco, Texas); Christopher M. Trebisovsky (Wylie, Texas) |
ABSTRACT | A receiver apparatus and method for optimized decryption and despreading of a very low frequency (VLF) bitstream is disclosed. In embodiments, the receiver includes antenna elements for receiving a transmission security (TRANSEC) encoded bitstream associated with an uncertainty window size and a spread factor. The receiver includes cryptographic processors that, when the spread factor is sufficiently large, select key section numbers A and data section numbers B based on the window size and spread factor. The cryptographic processors generate an output sequence of correlation windows, each correlation window associated with a symbol of the bitstream, via pipelined sectional mirrored-key convolution based on a key section number A and data section number B chosen to optimize performance (e.g., processor performance, memory performance). |
FILED | Thursday, April 08, 2021 |
APPL NO | 17/225926 |
CURRENT CPC | Electric Digital Data Processing G06F 17/142 (20130101) G06F 21/72 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/065 (20130101) Original (OR) Class H04L 9/0825 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328943 | Jones et al. |
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FUNDED BY |
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APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
INVENTOR(S) | Christopher L. Jones (Georgetown, Texas); Paul W. Davis (Austin, Texas); Dylan George (Austin, Texas); Jonathon E. Kruger (Pflugerville, Texas) |
ABSTRACT | Methods and structures are disclosed for self-automating a process of determining a device's location based on its network address. A computing device includes a network interface configured to communicate with a physical port of a network switch and a memory configured to store a plurality of different initialization protocols each associated with a corresponding network address of a plurality of network addresses. Each of the initialization protocols may be associated with a different physical location. The computing device also includes a processor configured to attempt to connect to the network switch via the network interface using a network address from the stored plurality of network addresses. In response to connecting with the network switch using the network address, the processor identifies a corresponding initialization protocol associated with the network address and executes the corresponding initialized procedure. |
FILED | Wednesday, April 15, 2020 |
APPL NO | 16/849446 |
CURRENT CPC | Electric Digital Data Processing G06F 9/4401 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 45/745 (20130101) H04L 49/351 (20130101) Original (OR) Class H04L 61/25 (20130101) H04L 61/6022 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210329026 | Bogdan et al. |
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FUNDED BY |
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APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Paul Bogdan (Los Angeles, California); Yuankun Xue (Los Angeles, California) |
ABSTRACT | Methods, systems, devices and apparatuses for reconstructing a network. The network reconstruction system includes a processor. The processor is configured to determine an unknown sub-network of a network. The unknown sub-network includes multiple unknown nodes and multiple unknown links. The processor is configured to determine the unknown sub-network based on a known sub-network that has multiple known nodes and multiple known links, a network model and an attacker's statistical behavior to reconstruct the network. The processor is configured to determine one or more network parameters of the network. The network processor is configured to provide a probability of an outcome of an input or observation into the network or into a second network that has the one or more network parameters of the network. |
FILED | Monday, April 12, 2021 |
APPL NO | 17/227966 |
CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/145 (20130101) H04L 41/147 (20130101) H04L 41/0866 (20130101) H04L 63/1425 (20130101) H04L 63/1441 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
US 20210321954 | Iasemidis et al. |
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FUNDED BY |
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APPLICANT(S) | LOUISIANA TECH RESEARCH CORPORATION (Ruston, Louisiana) |
ASSIGNEE(S) | |
INVENTOR(S) | Leonidis Iasemidis (Ruston, Louisiana); Timothy N. Hutson (Ruston, Louisiana) |
ABSTRACT | Network analysis of a patient's neuro-cardio-respiratory system can be performed to detect an impending crisis, diagnose an abnormality, and/or provide informative feedback about a treatment regime. A system can receive data recorded by one or more recording devices from a patient. The data is time varying and related to two or more organs of the patient's neuro-cardio-respiratory system that are monitored. The system can estimate directional interactions between the two or more organs within the patient's body over time via a mathematical analysis of the data to identify one or more pathologies in a network of the neuro-cardio-respiratory system. When the one or more pathologies are identified, the system can provide the advance warning of the impending crisis, the diagnosis of the abnormality, or the informative feedback for the treatment regime. |
FILED | Tuesday, September 03, 2019 |
APPL NO | 17/271961 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/021 (20130101) A61B 5/0035 (20130101) A61B 5/0245 (20130101) A61B 5/4035 (20130101) A61B 5/4064 (20130101) A61B 5/4082 (20130101) A61B 5/4094 (20130101) A61B 5/4818 (20130101) A61B 5/7275 (20130101) Original (OR) Class A61B 5/7282 (20130101) A61B 2560/02 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/30 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210321975 | Sikdar et al. |
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FUNDED BY |
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APPLICANT(S) | George Mason University (Fairfax, Virginia) |
ASSIGNEE(S) | |
INVENTOR(S) | Siddhartha Sikdar (Washginton, District of Columbia); Parag Chitnis (Burke, Virginia); Biswarup Mukherjee (Fairfax, Virginia); Joseph Majdi (Fairfax, Virginia) |
ABSTRACT | A low-power (e.g., battery-operated, etc.) wearable ultrasound system may be used to monitor the musculoskeletal function of a subject and provide information that may be used for electrical stimulation. |
FILED | Wednesday, April 21, 2021 |
APPL NO | 17/236752 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) Original (OR) Class A61B 8/488 (20130101) A61B 8/5223 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36003 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 30/40 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322004 | Khanicheh et al. |
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FUNDED BY |
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APPLICANT(S) | EnVision Endoscopy, Inc. (Somerville, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Azadeh Khanicheh (Somerville, Massachusetts); Isaac Ostrovsky (Wellesley, Massachusetts) |
ABSTRACT | Provided herein is an endoscopic suturing system configured for attachment to, and use with, an endoscope. |
FILED | Tuesday, June 22, 2021 |
APPL NO | 17/354649 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/0469 (20130101) Original (OR) Class A61B 17/0491 (20130101) A61B 2017/047 (20130101) A61B 2017/00473 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322333 | Astete et al. |
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FUNDED BY |
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APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
INVENTOR(S) | Carlos Astete (Baton Rouge, Louisiana); Cristina Sabliov (Baton Rouge, Louisiana) |
ABSTRACT | Amphiphilic biopolymers have been synthesized by grafting lignin onto PLGA to form graft polymers, which can then be further assembled into polymeric nanoparticles without a requirement for surfactants. The nanoparticles have a typical diameter of 75 nm. The nanoparticles may be used, for example, for drug delivery, including efficient and effective drug delivery against cancers such as triple negative breast cancers. |
FILED | Wednesday, October 09, 2019 |
APPL NO | 17/283730 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) Original (OR) Class A61K 9/5192 (20130101) A61K 31/437 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 81/00 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322394 | Zhang |
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FUNDED BY |
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APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
INVENTOR(S) | Chunhua Zhang (West Lafayette, Indiana) |
ABSTRACT | In one embodiment, the present application relates to methods and materials for weed control of a field of a crop plant using a cellulose biosynthesis inhibitor selected from the group consisting of ES20 and ES20-1 to ES20-9 of FIG. 1A. In another embodiment, the present disclosure relates to a method for treatment or prevention of an infection through inhibition of biofilm formation of microorganisms comprising the step of applying a therapeutic effective amount of a cellulose biosynthesis inhibitor selected from the group consisting of ES20 and ES20-1˜ES20-9 of FIG. 1A, or a salt thereof, in combination with one or more other commonly used antibiotics. A composition matter comprising said compounds and methods of use are within the scope of the present invention. |
FILED | Friday, April 02, 2021 |
APPL NO | 17/220975 |
CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 47/30 (20130101) A01N 47/34 (20130101) A01N 47/36 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/44 (20130101) Original (OR) Class A61K 31/381 (20130101) A61K 45/06 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/16 (20130101) A61L 2/0082 (20130101) A61L 2101/40 (20200801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322557 | Burdick et al. |
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FUNDED BY |
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APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
ASSIGNEE(S) | |
INVENTOR(S) | Jason Alan Burdick (Philadelphia, Pennsylvania); Sujata Sahoo (Wilmington, Delaware); Cindy Chung (Parsippany, New Jersey) |
ABSTRACT | Provided are polysaccharide compositions capable of controllable hydrolytic degradation and suitable for controlled release of therapeutic agents. Also provided are methods for synthesizing such compositions and a variety of applications in which the compositions may be used. |
FILED | Wednesday, June 23, 2021 |
APPL NO | 17/355660 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/36 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/3834 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) A61L 2300/442 (20130101) A61L 2300/604 (20130101) A61L 2430/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 5/0663 (20130101) C12N 2533/40 (20130101) C12N 2533/80 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322567 | Yang et al. |
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FUNDED BY |
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APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL PROPERTY FOUNDATION (Richmond, Virginia) |
ASSIGNEE(S) | |
INVENTOR(S) | Hu Yang (Glen Allen, Virginia); Shobha Ghosh (Glen Allen, Virginia); Hongliang He (Richmond, Virginia); Michael Lancina (Richmond, Virginia) |
ABSTRACT | The present disclosure relates to carbohydrate-functionalized nanoparticles and methods of treating cardiovascular disease (for example, atherosclerosis). |
FILED | Friday, October 27, 2017 |
APPL NO | 16/345303 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 38/465 (20130101) A61K 47/26 (20130101) A61K 47/60 (20170801) A61K 47/6935 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322950 | JIAO et al. |
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APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
INVENTOR(S) | SHICHAO JIAO (PITTSBURGH, Pennsylvania); JOSEPH JOHN MCCARTHY (GLENSHAW, Pennsylvania) |
ABSTRACT | The invention relates to novel composites for capture, e.g., absorption, of condensable gases and vapors from atmospheric sources, and gas or vapor streams, and the recovery of the condensed gases and vapors from the composites, as well as passive methods absent of external sources of energy for conducting the capturing and recovery processes. The composites include a hydrophilic matrix; hydrophilic solids embedded or immersed in the matrix, in close proximity to each other; and porogenic material embedded in the matrix, having a size larger than the hydrophilic solids; wherein selective removal of the porogenic material from the matrix forms a hierarchically porous matrix. |
FILED | Monday, October 28, 2019 |
APPL NO | 17/271463 |
CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/10 (20130101) Original (OR) Class B01J 20/28 (20130101) B01J 20/261 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 120/14 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323045 | Lujan et al. |
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APPLICANT(S) | BOISE STATE UNIVERSITY (Boise, Idaho) |
ASSIGNEE(S) | |
INVENTOR(S) | Trevor Lujan (Boise, Idaho); Sean Nelson (Meridian, Idaho); Madison Wale (Boise, Idaho); Danielle Siegel (Boise, Idaho); Jaremy Creechley (Laramie, Wyoming) |
ABSTRACT | A system may include a blade die, a first clamping caul positioned on a first side of the blade die, and a second clamping caul positioned on a second side of the blade die. A molding surface of the blade die and a molding surface of the first clamping caul may be configured to bend a first interchangeable blade positioned therebetween into a first shape in response to a first compression force. A second molding surface of the blade die and a molding surface of the second clamping caul may be configured to bend a second interchangeable blade positioned therebetween into a second shape in response to a second compression force. |
FILED | Monday, April 19, 2021 |
APPL NO | 17/234606 |
CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 28/34 (20130101) Original (OR) Class B21D 43/003 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323058 | Sandhage |
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FUNDED BY |
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APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
ASSIGNEE(S) | |
INVENTOR(S) | Kenneth Henry Sandhage (Lafayette, Indiana) |
ABSTRACT | Methods for producing final bodies that contain a fine-grained refractory complex concentrated alloy (RCCA), as well as RCCAs, intermediate materials and final bodies containing the RCCAs, and high-temperature devices formed by such final bodies. Such a method includes providing a precursor with one or more precursor compounds containing elements of an RCCA, reducing the precursor compounds in the precursor via reaction with a reducing agent so as to generate the RCCA and a compound comprising a product of the reaction between the reducing agent and the precursor compounds, generating a solid material that contains at least the RCCA, forming with the solid material a porous intermediate body, and consolidating the porous intermediate body so as to partially or completely remove the pore volume from the porous intermediate body, and in doing so yield either a denser final body or a denser film. |
FILED | Monday, March 22, 2021 |
APPL NO | 17/208424 |
CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/001 (20130101) Original (OR) Class B22F 3/14 (20130101) B22F 3/16 (20130101) B22F 3/1143 (20130101) B22F 9/20 (20130101) B22F 9/24 (20130101) B22F 9/30 (20130101) B22F 2003/145 (20130101) B22F 2301/20 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323983 | Toutov et al. |
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APPLICANT(S) | California Institute Of Technology (Pasadena, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Anton Toutov (Magnolia, Texas); Wenbo Liu (Wuhan, China PRC); David P. Schuman (Pasadena, California); Brian M. Stoltz (San Marino, California); Robert H. Grubbs (South Pasadena, California) |
ABSTRACT | The present disclosure is directed to methods of silylating organic substrates containing C—H or O—H bonds. In some embodiments, the methods use compositions that are derived from the preconditioning of mixtures of hydrosilanes or organodisilanes with bases, including metal hydroxide, metal alkoxide, metal silanoates, potassium amides, and/or graphitic potassium bases. |
FILED | Thursday, May 27, 2021 |
APPL NO | 17/332394 |
CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/0814 (20130101) Original (OR) Class C07F 7/0896 (20130101) C07F 7/1804 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324121 | Liebfarth et al. |
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FUNDED BY |
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APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Frank Liebfarth (Carrboro, North Carolina); Aaron Teator (Chapel Hill, North Carolina) |
ABSTRACT | Disclosed herein are isotactic polyvinyl ethers and improved methods of making same. The method disclosed herein can produce polyvinyl ethers having a higher isotacticity as compared to polyvinyl ethers prepared with conventional methods. |
FILED | Thursday, August 15, 2019 |
APPL NO | 17/269247 |
CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 216/20 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324129 | Youngblood et al. |
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FUNDED BY |
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APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
INVENTOR(S) | Jeffrey Paul Youngblood (West Lafayette, Indiana); Matthew Korey (Hamilton, Ohio); John Alan Howarter (West Lafayette, Indiana); Natalie Burgos (West Lafayette, Indiana) |
ABSTRACT | The present disclosure provides to a novel flame retardant resin, wherein the resin is a reaction product of an epoxy material, a curing agent, and a partially esterified tannic acid of formula I, wherein TA represents a tannic acid moiety, R1 represents an optionally substituted C1-C6 straight or branched alkyl, an optionally substituted C3-C6 cyclic ring, an optionally substituted phenyl group, or any combination thereof, and n is 2-10. |
FILED | Monday, February 15, 2021 |
APPL NO | 17/175748 |
CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 283/10 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324360 | CHEN et al. |
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APPLICANT(S) | The Regents of the University of California (Oakland, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Yvonne Y. CHEN (Los Angeles, California); Patrick HO (Fremont, California) |
ABSTRACT | Compositions and methods are provided for the cell-mediated targeted killing of diseased cells based on the presence of an intracellular antigen, rather than a surface-bound marker. The targeting cells are modified to express a cytotoxic protein that is delivered into a targeted cell, and after delivery is selectively activated by the presence of a cytoplasmic protein of interest. In one embodiment of the invention, the cytotoxic molecule is a Granzyme B (GrB) polypeptide. In the compositions of the invention, GrB is modified to render its cytotoxic enzymatic functions inactive, until the presence of an intracellular antigen unlocks the GrB molecule to enable enzymatic activities. |
FILED | Thursday, June 24, 2021 |
APPL NO | 17/357704 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/482 (20130101) Peptides C07K 14/47 (20130101) C07K 14/4702 (20130101) C07K 16/40 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/64 (20130101) C12N 9/6467 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2510/00 (20130101) Enzymes C12Y 304/21079 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324366 | DANIEL et al. |
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FUNDED BY |
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APPLICANT(S) | Cornell University (Ithaca, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Susan DANIEL (Ithaca, New York); Martin STUEBLER (Ithaca, New York); Han-Yuan LIU (Ithaca, New York) |
ABSTRACT | Provided herein are compositions comprising a plant plasma membrane supported on a surface of an object, wherein the plant plasma membrane is not associated with a plant cell. |
FILED | Thursday, July 11, 2019 |
APPL NO | 17/258863 |
CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/08 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324442 | BUNDY et al. |
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FUNDED BY |
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APPLICANT(S) | Brigham Young University (Provo, Utah) |
ASSIGNEE(S) | |
INVENTOR(S) | Bradley C. BUNDY (Provo, Utah); J. Porter HUNT (Provo, Utah) |
ABSTRACT | Disclosed herein are biosensors including transcription, translation, and coupled transcription/translation systems. The biosensors may be made from cell lysates, purified enzymes, or a combination thereof. The biosensors may include an inhibitor, and may include a reporter. The biosensor may be supplied in a kit for testing for a disease or condition. Methods of using the biosensor are also disclosed. |
FILED | Wednesday, January 06, 2021 |
APPL NO | 17/142932 |
CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/9124 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324456 | Cunningham et al. |
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FUNDED BY |
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APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Brian T. Cunningham (Champaign, Illinois); Yue Zhuo (Champaign, Illinois); Brendan Harley (Urbana, Illinois); Ji Sun Choi (Urbana, Illinois); Thibault Marin (Champaign, Illinois); Yi Lu (Champaign, Illinois) |
ABSTRACT | A digital assay for a micro RNA (miRNA) or other target analyte in a sample makes use of nanoparticles that absorb light at the resonant wavelength of a photonic crystal (PC). Such nanoparticles locally quench the resonant reflection of light from the PC when present on the surface of the PC. The nanoparticles are functionalized to specifically bind to the target analyte, and the PC surface is functionalized to specifically bind to the nanoparticles that have bound to the target analyte. The sample is exposed to the functionalized nanoparticles, and the individual nanoparticles bound to the PC surface can be identified and counted based on reduced intensity values in the reflected light from the PC. The number of bound nanoparticles that are counted in this way can be correlated to the abundance of the target analyte in the sample. |
FILED | Monday, May 24, 2021 |
APPL NO | 17/328752 |
CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/178 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/554 (20130101) G01N 21/774 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324512 | Wu et al. |
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APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
ASSIGNEE(S) | |
INVENTOR(S) | Judy Z. Wu (Lawrence, Kansas); Qingfeng Liu (Nanjing, China PRC) |
ABSTRACT | A method of making a plasmonic metal/graphene heterostructure comprises heating an organometallic complex precursor comprising a metal at a first temperature T1 for a first period of time t1 to deposit a layer of the metal on a surface of a heated substrate, the heated substrate in fluid communication with the precursor; and heating, in situ, the precursor at a second temperature T2 for a second period of time t2 to simultaneously form on the layer of the metal, a monolayer of graphene and a plurality of carbon-encapsulated metal nanostructures comprising the metal, thereby providing the plasmonic metal/graphene heterostructure. The heated substrate is characterized by a third temperature T3. The plasmonic metal/graphene heterostructures, devices incorporating the heterostructures, and methods of using the heterostructures are also provided. |
FILED | Wednesday, July 03, 2019 |
APPL NO | 17/255817 |
CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/30 (20130101) Original (OR) Class C23C 16/448 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/028 (20130101) H01L 31/0232 (20130101) H01L 31/02161 (20130101) H01L 31/02363 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324537 | Li et al. |
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FUNDED BY |
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APPLICANT(S) | Wenzhi Li (Palmetto Bay, Florida); Yuba Poudel (Miami, Florida) |
ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
INVENTOR(S) | Wenzhi Li (Palmetto Bay, Florida); Yuba Poudel (Miami, Florida) |
ABSTRACT | Filled carbon nanotubes (CNTs) and methods of synthesizing the same are provided. An in situ chemical vapor deposition technique can be used to synthesize CNTs filled with metal sulfide nanowires. The CNTs can be completely and continuously filled with the metal sulfide fillers up to several micrometers in length. The filled CNTs can be easily collected from the substrates used for synthesis using a simple ultrasonication method. |
FILED | Thursday, April 16, 2020 |
APPL NO | 16/850687 |
CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/162 (20170801) C01B 32/178 (20170801) C01B 2202/06 (20130101) C01B 2202/10 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2002/84 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/186 (20130101) C30B 29/46 (20130101) C30B 29/66 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324539 | Cera et al. |
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FUNDED BY |
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APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Luca Cera (Cambridge, Massachusetts); Kevin Kit Parker (Cambridge, Massachusetts) |
ABSTRACT | The present invention provides methods for preparing an alpha-keratin solution comprising alpha-keratin protofibrils and intermediate filaments in liquid crystal phase and uses thereof for fabricating, e.g., shape-memory polymeric fibers, yarns, threads, fabrics, structures and objects. |
FILED | Friday, July 26, 2019 |
APPL NO | 17/262318 |
CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 1/02 (20130101) Original (OR) Class D01D 5/06 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/00 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2211/02 (20130101) D10B 2401/046 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324550 | Zhu et al. |
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FUNDED BY |
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APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Yong Zhu (Apex, North Carolina); Shanshan Yao (Coram, New York) |
ABSTRACT | Multi-functional electronic textiles employing nanocomposite pattern elements and related methods are provided. An exemplary method for producing a textile product with an integrated electrical device includes applying conductive nanowires to a substrate to form a conductive nanowire network on the substrate and applying a thermoplastic elastomer to the nanowire network to form a nanocomposite layer on top of the substrate. The method also includes cutting the nanocomposite layer into a desired pattern to form an electrical device and transferring the electrical device from the substrate onto a textile fabric. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/232095 |
CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 1/002 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 8/04 (20130101) Woven Fabrics; Methods of Weaving; Looms D03D 1/0088 (20130101) Original (OR) Class Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 10/06 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325072 | LIN et al. |
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APPLICANT(S) | Robert Bosch GmbH (Stuttgart, Germany) |
ASSIGNEE(S) | |
INVENTOR(S) | Shan LIN (Jericho, New York); Sirajum MUNIR (Pittsburgh, Pennsylvania) |
ABSTRACT | A thermal state of a plurality of zones of the building is updated according to a building thermal model and information received from temperature sensors of the building. Predicted occupant counts for an upcoming plurality of time slots for each of the plurality of zones are updated using actual occupancy counts for each of the plurality of zones. A misprediction type distribution for the upcoming plurality of time slots for each of the plurality of zones is updated, the misprediction type distribution indicating misprediction for true negatives, false positives, false negatives, and true positives. A total misprediction cost expectation is updated according to the predicted occupant counts and the misprediction type distribution. HVAC power for each of the plurality of zones is determined to optimize occupant thermal comfort weighted according to the predicted occupant counts while minimizing the total misprediction cost expectation. HVAC operation is controlled per the HVAC power. |
FILED | Thursday, April 16, 2020 |
APPL NO | 16/850860 |
CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/47 (20180101) F24F 11/48 (20180101) F24F 11/65 (20180101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325185 | Das |
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APPLICANT(S) | KUTZTOWN UNIVERSITY OF PENNSYLVANIA (Kutztown, Pennsylvania) |
ASSIGNEE(S) | |
INVENTOR(S) | Kunal Das (Reading, Pennsylvania) |
ABSTRACT | Embodiments relate to a sensor system configured to detect physical rotation, entire or relative, of one or more objects and/or their environment and/or proximity of a magnetic field, by measuring the degree of localization of a medium trapped in a ring-shaped artificial lattice. The lattice structure can be configured to comprise of lattice sites distributed with a lattice period around an azimuth of a closed ring. The site depths of the plurality of lattice sites can be configured to be modulated with a modulation period different from the lattice period to affect the onsite energies of each lattice site and the eigenstates of the system. Physical rotation of the sensor and/or the proximity of magnetic field will alter the localization properties so as to cause the degree of localization of the medium to change (e.g., the medium becomes more confined in space or more spread out in space). |
FILED | Tuesday, November 12, 2019 |
APPL NO | 16/617894 |
CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/58 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/032 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325282 | DIMAURO |
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FUNDED BY |
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APPLICANT(S) | Sunghee Lee DIMAURO (Stamford, Connecticut) |
ASSIGNEE(S) | Iona College (New Rochelle, New York) |
INVENTOR(S) | Sunghee Lee DIMAURO (Stamford, Connecticut) |
ABSTRACT | The present disclosure relates to compositions and methods for clearing biological materials. Specifically, the present disclosure relates to increasing the transparency of biological materials via contact with clearing composition comprising a solution of polyoxometallate salt. |
FILED | Sunday, June 27, 2021 |
APPL NO | 17/359609 |
CURRENT CPC | Detergent Compositions; Use of Single Substances as Detergents; Soap or Soap-making; Resin Soaps; Recovery of Glycerol C11D 3/168 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/34 (20130101) Original (OR) Class G01N 21/41 (20130101) G01N 33/4833 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325301 | Porter et al. |
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FUNDED BY |
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APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
ASSIGNEE(S) | |
INVENTOR(S) | Christina Porter (Superior, Colorado); Daniel E. Adams (Thornton, Colorado); Michael Tanksalvala (Longmont, Colorado); Elisabeth Shanblatt (Boulder, Colorado); Margaret M. Murnane (Boulder, Colorado); Henry C. Kapteyn (Boulder, Colorado) |
ABSTRACT | Apparatus and methods for complex imaging reflectometry and refractometry using at least partially coherent light. Quantitative images yield spatially-dependent, local material information about a sample of interest. These images may provide material properties such as chemical composition, the thickness of chemical layers, dopant concentrations, mixing between layers of a sample, reactions at interfaces, etc. An incident beam of VUV wavelength or shorter is scattered off of a sample and imaged at various angles, wavelengths, and/or polarizations. The power of beam is also measured. This data is used to obtain images of a sample's absolute, spatially varying, complex reflectance or transmittance, which is then used to determine spatially-resolved, depth-dependent sample material properties. |
FILED | Monday, April 12, 2021 |
APPL NO | 17/228178 |
CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/33 (20130101) G01N 21/45 (20130101) G01N 21/956 (20130101) G01N 21/4788 (20130101) Original (OR) Class G01N 21/4795 (20130101) G01N 2021/1782 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325329 | Bandara et al. |
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FUNDED BY |
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APPLICANT(S) | Southern Methodist University (Dallas, Texas); University of Rhode Island Board of Trustees (Kingston, Rhode Island) |
ASSIGNEE(S) | |
INVENTOR(S) | Y.M. Nuwan D.Y. Bandara (Canberra, Australia); Buddini I. Karawdeniya (Canberra, Australia); Jugal Saharia (Dallas, Texas); Min Jun Kim (Plano, Texas); Jason Rodger Dwyer (Providence, Rhode Island) |
ABSTRACT | The present invention includes one or more nanopores in a SixNy membrane comprising a monoprotic surface termination, methods of making, and methods of using the one or more nanopores, where the one or more nanopores are a chemically-tuned controlled dielectric breakdown (CT-CDB) nanopore membrane, wherein the CT-CDB allows for long-term stability of measurements in the presence of only electrolyte (open pore current stability) and ability to support many molecular detection events. In addition, the CT-CBD has pore that unclog spontaneously, in response to voltage cessation or application, or both. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/232624 |
CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/127 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325386 | McGrath |
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FUNDED BY |
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APPLICANT(S) | University of Rochester (Rochester, New York) |
ASSIGNEE(S) | University of Rochester (Rochester, New York) |
INVENTOR(S) | James L. McGrath (Fairport, New York) |
ABSTRACT | The invention provides devices and methods for detecting viruses, bacteria, and other analytes of interest in a fluid sample. The fluid sample flows through a first microfluidic channel to a nanoporous or microporous membrane on which are disposed ligands, such as antibodies, specific for the analyte. If the analyte of interest is captured by the ligand, it clogs the pores of the membrane, preventing the fluid sample from passing through the membrane and diverting the fluid into a second channel. Detecting movement of the fluid sample in the second channel signals the presence of the analyte in the fluid sample, while failure of the fluid sample to move in the second channel signals absence of the analyte in the fluid sample. |
FILED | Monday, February 15, 2021 |
APPL NO | 17/176135 |
CURRENT CPC | Separation B01D 39/2068 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/569 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325392 | Buranda et al. |
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FUNDED BY |
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APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
ASSIGNEE(S) | |
INVENTOR(S) | Tione Buranda (Albuquerque, New Mexico); Jacob Ongudi Agola (Albuquerque, New Mexico); Soumik BasuRay (Dallas, Texas); Scarlett Swanson (Albuquerque, New Mexico); Angela Wandinger-Ness (Albuquerque, New Mexico); Peter C. Simons (Albuquerque, New Mexico); Virginie Bondu (Albuquerque, New Mexico) |
ABSTRACT | In one embodiment, the invention provides a method of diagnosing sepsis or a virus-related infection (often a viral hemorrhagic fever infection) in a subject by detecting and measuring the level of a set of sepsis and virus infection-associated-GTPase biomarkers in a sample obtained from the subject using multiplexed flow cytometry. Related kits are also provided. In a preferred embodiment, the invention provides point of care diagnostic methods for determining an early stage sepsis or the severity of a virus infection, especially in a hospital or other setting. |
FILED | Tuesday, February 23, 2021 |
APPL NO | 17/182859 |
CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) G01N 33/573 (20130101) Original (OR) Class G01N 2333/914 (20130101) G01N 2800/26 (20130101) G01N 2800/224 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325459 | Hanna et al. |
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APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (KANSAS CITY, Missouri) |
ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (KANSAS CITY, Missouri) |
INVENTOR(S) | Charles John Hanna (Gardner, Kansas); Tuan N. Nguyen (Olathe, Kansas); Will Schulte Plamann (Leawood, Kansas) |
ABSTRACT | A method of testing a PIN diode for a power limiter circuit comprises measuring a reverse bias current of the PIN diode; applying a reverse bias voltage to the PIN diode; increasing the reverse bias voltage until the reverse bias current of the PIN diode reaches a threshold current indicative of a reverse voltage breakdown; and determining whether the reverse bias breakdown voltage of the PIN diode is within an acceptable range of reverse bias breakdown voltages corresponding to a power range at which the power limiter circuit would enter power limiting mode with the PIN diode. |
FILED | Friday, April 17, 2020 |
APPL NO | 16/851328 |
CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/31713 (20130101) Original (OR) Class Control of Amplification H03G 11/02 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325586 | Van Dokkum et al. |
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APPLICANT(S) | Yale University (New Haven, Connecticut) |
ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
INVENTOR(S) | Pieter Van Dokkum (New Haven, Connecticut); Roberto Abraham (Oakville, Canada); Deborah Lokhorst (Toronto, Canada) |
ABSTRACT | One aspect of the invention provides a telescope including: at least one lens or mirror arranged to receive collimated light defining an optical axis at a first end and form an image at a last end; and a narrowband interference filter positioned along the optical axis prior to the first end. The narrowband interference filter is tiltably mounted with respect to the optical axis. Another aspect of the invention provides an imager including: an optical collimator; a plurality of lenses or mirrors arranged relative to the optical collimator to receive collimated light from the optical collimator defining an optical axis at a first end and form an image at a second end; and a narrowband interference filter positioned along the optical axis between the optical collimator and the first end. The narrowband interference filter is tiltably mounted with respect to the optical axis. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/231150 |
CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/28 (20130101) Original (OR) Class G02B 23/00 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325656 | Liu et al. |
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APPLICANT(S) | University of Washington (Seattle, Washington) |
ASSIGNEE(S) | University of Washington (Seattle, Washington) |
INVENTOR(S) | Jonathan T.C. Liu (Seattle, Washington); Lindsey A. Barner (Seattle, Washington); Adam K. Glaser (Seattle, Washington) |
ABSTRACT | Apparatuses, systems, and methods for solid immersion meniscus lenses (SIMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices. |
FILED | Wednesday, June 23, 2021 |
APPL NO | 17/356135 |
CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/0032 (20130101) G02B 21/33 (20130101) Original (OR) Class G02B 21/248 (20130101) G02B 21/367 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210326163 | Gopalan |
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FUNDED BY |
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APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Kartik Gopalan (Vestal, New York) |
ABSTRACT | A multi-hypervisor system, comprising: a plurality of hypervisors comprising a first hypervisor and a second hypervisor, at least one of the plurality of hypervisors being a transient hypervisor; and at least one Span VM, concurrently executing on each of the plurality of hypervisors, the at least one transient hypervisor being adapted to be dynamically at least one of injected and removed under the at least one Span VM concurrently with execution of the at least one Span VM on another hypervisor, wherein the at least one Span VM has a single and consistent at least one of memory space, virtual CPU state, and set of input/output resources, shared by the plurality of hypervisors. |
FILED | Monday, May 24, 2021 |
APPL NO | 17/327828 |
CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) Original (OR) Class G06F 2009/45562 (20130101) G06F 2009/45566 (20130101) G06F 2009/45579 (20130101) G06F 2009/45583 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210326704 | George |
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APPLICANT(S) | UNIVERISTY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
ASSIGNEE(S) | |
INVENTOR(S) | Jacob Anthony George (Salt Lake City, Utah) |
ABSTRACT | A method for training an artificial intelligence (AI) model for allowing a user to intuitively control an electronic device includes positioning a plurality of sensors at a plurality of particular positions on a human body for sensing electric signals. The method also includes recording a first set of electric signals from each of the plurality of sensors in a continuous manner. At the same time, a first set of motion intents associated with a first sequence of body movement is also recorded in a continuous manner. An AI regression model is trained using a neural network to map the first set of electric signals to the first set of motion intents. In response to receiving a second set of electric signals from the plurality of sensors in a continuous manner, the AI regression model predicts a motion intent, causing the electronic device to perform an action. |
FILED | Wednesday, April 14, 2021 |
APPL NO | 17/230446 |
CURRENT CPC | Electric Digital Data Processing G06F 3/014 (20130101) G06F 3/015 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) Original (OR) Class G06N 3/063 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327133 | Redden et al. |
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APPLICANT(S) | Blue River Technology Inc. (Sunnyvale, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Lee Kamp Redden (Palo Alto, California); Nicholas Apostoloff (San Jose, California) |
ABSTRACT | A technique for generating virtual models of plants in a field is described. Generally, this includes recording images of plants in-situ; generating point clouds from the images; generating skeleton segments from the point cloud; classifying a subset of skeleton segments as unique plant features using the images; and growing plant skeletons from skeleton segments classified as unique plant feature. The technique may be used to generate a virtual model of a single, real plant, a portion of a real plant field, and/or the entirety of the real plant field. The virtual model can be analyzed to determine or estimate a variety of individual plant or plant population parameters, which in turn can be used to identify potential treatments or thinning practices, or predict future values for yield, plant uniformity, or any other parameter can be determined from the projected results based on the virtual model. |
FILED | Friday, May 21, 2021 |
APPL NO | 17/327516 |
CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/33 (20170101) G06T 7/74 (20170101) G06T 7/194 (20170101) G06T 7/337 (20170101) G06T 7/344 (20170101) G06T 15/08 (20130101) G06T 17/05 (20130101) Original (OR) Class G06T 17/20 (20130101) G06T 2210/56 (20130101) G06T 2219/2008 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327474 | Seok et al. |
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FUNDED BY |
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APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Mingoo Seok (Tenafly, New Jersey); Zhewei Jiang (Oakland Gardens, New York); Jae-sun Seo (Tempe, Arizona); Shihui Yin (Mesa, Arizona) |
ABSTRACT | In some embodiments, an in-memory-computing SRAM macro based on capacitive-coupling computing (C3) (which is referred to herein as “C3SRAM”) is provided. In some embodiments, a C3SRAM macro can support array-level fully parallel computation, multi-bit outputs, and configurable multi-bit inputs. The macro can include circuits embedded in bitcells and peripherals to perform hardware acceleration for neural networks with binarized weights and activations in some embodiments. In some embodiments, the macro utilizes analog-mixed-signal capacitive-coupling computing to evaluate the main computations of binary neural networks, binary-multiply-and-accumulate operations. Without needing to access the stored weights by individual row, the macro can assert all of its rows simultaneously and form an analog voltage at the read bitline node through capacitive voltage division, in some embodiments. With one analog-to-digital converter (ADC) per column, the macro cab realize fully parallel vector-matrix multiplication in a single cycle in accordance with some embodiments. |
FILED | Wednesday, June 23, 2021 |
APPL NO | 17/356211 |
CURRENT CPC | Electric Digital Data Processing G06F 7/501 (20130101) G06F 7/5443 (20130101) Static Stores G11C 7/1036 (20130101) Original (OR) Class G11C 7/1051 (20130101) G11C 7/1078 (20130101) G11C 16/3404 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328021 | Hone et al. |
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APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
INVENTOR(S) | James Hone (New York, New York); James T. Teherani (New York, New York); Ankur Baburao Nipane (New York, New York); Minsup Choi (New York, New York); Younghun Jung (New York, New York); Abhinandan Borah (New York, New York) |
ABSTRACT | Disclosed are compositions and methods of semiconductors including tungsten oxyselenide (TOS) as a p-type dopant. The TOS is formed by introducing a single layer of tungsten diselenide (WSe2) to a semiconductor and subject the tungsten diselenide to a room-temperature UV plus ozone process. This process forms a TOS monolayer, which can be used as a universal p-type dopant for a variety of different semiconductors. Suitable semiconductor materials include, for example, graphene, carbon nanotubes, tungsten diselenide, and dinaphthothienothiophene (DNTT). |
FILED | Wednesday, April 21, 2021 |
APPL NO | 17/236404 |
CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/041 (20130101) H01L 21/385 (20130101) H01L 29/24 (20130101) H01L 29/167 (20130101) Original (OR) Class H01L 29/1606 (20130101) H01L 51/002 (20130101) H01L 51/0048 (20130101) H01L 51/0074 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328085 | Bradley et al. |
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APPLICANT(S) | PixelEXX Systems, Inc. (Westmont, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Kenneth Forbes Bradley (Hinsdale, Illinois); Marco Nardone (Bowling Green, Illinois); Renee Kathryn Carder (Hinsdale, Illinois) |
ABSTRACT | A Mie photo sensor is described. A Mie photo sensor is configured to leverage Mie scattering to implement a photo sensor having a resonance. The resonance is based on various physical and material properties of the Mie photo sensor. In an example, a Mie photo sensor includes a layer of semiconductor material with one or more mesas. Each mesa of semiconductor material may include a scattering center. The scattering center is formed by the semiconductor material of the mesa being at least partially surround by a material with a different refractive index than the semiconductor material. The abutting refractive index materials create an interface that forms a scattering center and localizes the generation of free carriers during Mie resonance. One or more electrical contacts may be made to the mesa to measure the electrical properties of the mesa. |
FILED | Thursday, April 08, 2021 |
APPL NO | 17/225994 |
CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/02327 (20130101) H01L 31/035281 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328087 | BURGER et al. |
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FUNDED BY |
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APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
INVENTOR(S) | Tobias BURGER (Ann Arbor, Michigan); Byungjun LEE (Ann Arbor, Michigan); Dejiu FAN (Ann Arbor, Michigan); Andrej LENERT (Ann Arbor, Michigan); Stephen R. FORREST (Ann Arbor, Michigan) |
ABSTRACT | To reach high efficiencies, thermophotovoltaic cells must utilize the broad spectrum of a radiative thermal source. One promising approach to overcome this challenge is to have low-energy photons reflected and reabsorbed by the thermal emitter, where their energy can have another chance at contributing toward photogeneration in the cell. However, current methods for photon recuperation are limited by insufficient bandwidth or parasitic absorption, resulting in large efficiency losses relative to theoretical limits. This work demonstrates nearly perfect reflection of low-energy photons (˜99%) by embedding an air layer within the TPV cell. This result represents a four-fold reduction in parasitic absorption relative to existing TPV cells. As out-of-band reflectance approaches unity, TPV efficiency becomes nearly insensitive to cell bandgap and emitter temperature. Accessing this regime unlocks a range of possible materials and heat sources that were previously inaccessible to TPV energy conversion. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/232243 |
CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/04 (20130101) C30B 25/22 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0005 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/043 (20141201) H01L 31/0264 (20130101) H01L 31/0687 (20130101) Original (OR) Class H01L 31/0735 (20130101) H01L 31/1852 (20130101) H01L 31/1896 (20130101) H01L 31/02327 (20130101) H01L 33/0093 (20200501) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328252 | Yang et al. |
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FUNDED BY |
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APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
ASSIGNEE(S) | |
INVENTOR(S) | Gang Yang (College Station, Texas); Choongho Yu (College Station, Texas) |
ABSTRACT | Embodiments of the claimed invention are directed to a device, comprising: an anode that includes a lithiated silicon-based or lithiated carbon-based material or pure lithium metal or metal oxides and a sandwich-type sulfur-based cathode, wherein the anode and the cathode are designed to have porous structures. An additional embodiment of the invention is directed to a scalable method of manufacturing sandwich-type Li—S batteries at a significantly reduced cost compared to traditional methods. An additional embodiment is directed to the use of exfoliated CNT sponges for enlarging the percentage of sulfur in the cathode to have large energy density. |
FILED | Tuesday, February 09, 2021 |
APPL NO | 17/171828 |
CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/80 (20130101) H01M 4/663 (20130101) H01M 10/052 (20130101) Original (OR) Class H01M 10/0585 (20130101) H01M 2004/021 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328319 | Krueger |
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FUNDED BY |
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APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
INVENTOR(S) | Daniel Scott Krueger (Liberty, Missouri) |
ABSTRACT | Waveguides and methods for manufacturing a waveguide that include forming a first channel in a first layer of dielectric material, the first channel comprising one or more walls; forming a second channel in a second layer of dielectric material, the second channel comprising one or more walls; depositing electrically conductive material on the one or more walls of the first channel; depositing electrically conductive material on the one or more walls of the second channel; arranging the first layer adjacent to the second layer to form a stack with the first channel axially aligned with and facing the second channel; and heating the stack so that the conductive material on the one or more walls of the first channel and the conductive material on the one or more walls of the second channel connect to form the waveguide. |
FILED | Friday, April 17, 2020 |
APPL NO | 16/851486 |
CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/16 (20130101) H01P 3/121 (20130101) Original (OR) Class H01P 11/006 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328360 | Yoon et al. |
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FUNDED BY |
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APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
ASSIGNEE(S) | |
INVENTOR(S) | Yong Kyu Yoon (Gainesville, Florida); Renuka Bowrothu (Gainesville, Florida); Haein Kim (Gainesville, Florida); Seahee Hwangbo (Beaverton, Oregon) |
ABSTRACT | The present disclosure describes various embodiments of systems, apparatuses, and methods for implementing an array antenna having a combination of ferromagnetic and nonferromagnetic conductors in alternating multilayers. One such antenna device comprises an array of patch antennas on a substrate, wherein the patch antennas are formed of a combination of ferromagnetic and nonferromagnetic conductors in alternating multilayers; and a microstrip feeding line coupled to the array of patch antennas. Other systems, apparatuses, and methods are also presented. |
FILED | Wednesday, April 14, 2021 |
APPL NO | 17/230347 |
CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/422 (20130101) H01Q 9/0414 (20130101) H01Q 21/065 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328777 | BROOKS et al. |
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FUNDED BY |
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APPLICANT(S) | Clemson University (Clemson, South Carolina) |
ASSIGNEE(S) | Clemson University (Clemson, South Carolina); University of Tennessee Research Foundation (Knoxville, Tennessee) |
INVENTOR(S) | RICHARD R. BROOKS (Clemson, South Carolina); LU YU (Clemson, South Carolina); ANTHONY SKJELLUM (Knoxville, Tennessee) |
ABSTRACT | The system can be for the management of access authorization using an immutable ledger comprising and can include a server having a computer readable medium in communications with an immutable ledger. A set of computer readable instructions can be included in the server and can be configured for: receiving a set of data, encrypting the set of data with a data-encryption-key and storing the encrypted data on the immutable ledger, creating a key tree having a node associated with a user, creating a key-encryption-key associated with the node and the user, and, distributing the key-encryption-key to the user wherein the key-encryption-key is configured to decrypt the data-encryption-key thereby providing access to the data for the user. |
FILED | Tuesday, April 20, 2021 |
APPL NO | 17/235279 |
CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0822 (20130101) Original (OR) Class H04L 9/0836 (20130101) H04L 9/0894 (20130101) H04L 9/3297 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328841 | Wu et al. |
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FUNDED BY |
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APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
INVENTOR(S) | Kefei Wu (Portland, Oregon); Mona Mostafa Hella (Watervliet, New York) |
ABSTRACT | A millimeter wave (MMW) circuitry includes a phase modulation circuitry, a plurality of amplifier multiplier chain circuitries and a power combiner circuitry. The phase modulation circuitry is configured to receive input data and a plurality of divided input signals and to provide as output a plurality of phase modulation circuitry output signals. Each phase modulation circuitry output signal corresponds to a respective divided input signal. At least one phase modulation circuitry output signal has a nonzero phase relative to the divided input signals that is related to the input data. Each amplifier multiplier chain circuitry is configured to amplify and frequency multiply and phase multiply the respective phase modulation circuitry output signal to yield a respective power combiner input signal. The power combiner circuitry is configured to sum a plurality of power combiner input signals to yield an output signal. A modulation of the output signal is related to the input data. |
FILED | Thursday, July 11, 2019 |
APPL NO | 17/259585 |
CURRENT CPC | Amplifiers H03F 3/245 (20130101) H03F 2200/451 (20130101) Pulse Technique H03K 5/00006 (20130101) H03K 2005/00286 (20130101) Transmission H04B 1/04 (20130101) H04B 2001/0408 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/20 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210329026 | Bogdan et al. |
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FUNDED BY |
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APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Paul Bogdan (Los Angeles, California); Yuankun Xue (Los Angeles, California) |
ABSTRACT | Methods, systems, devices and apparatuses for reconstructing a network. The network reconstruction system includes a processor. The processor is configured to determine an unknown sub-network of a network. The unknown sub-network includes multiple unknown nodes and multiple unknown links. The processor is configured to determine the unknown sub-network based on a known sub-network that has multiple known nodes and multiple known links, a network model and an attacker's statistical behavior to reconstruct the network. The processor is configured to determine one or more network parameters of the network. The network processor is configured to provide a probability of an outcome of an input or observation into the network or into a second network that has the one or more network parameters of the network. |
FILED | Monday, April 12, 2021 |
APPL NO | 17/227966 |
CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/145 (20130101) H04L 41/147 (20130101) H04L 41/0866 (20130101) H04L 63/1425 (20130101) H04L 63/1441 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
US 20210321934 | Arnold et al. |
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FUNDED BY |
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APPLICANT(S) | KNOW BIOLOGICAL, INC. (Milton, Georgia); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
ASSIGNEE(S) | |
INVENTOR(S) | Gary Stephen Arnold (Cumming, Georgia); Matthew Wallace Moorman (Albuquerque, New Mexico); Joshua Jonathan Whiting (Albuquerque, New Mexico) |
ABSTRACT | A volatile organic compound collector can include a collector material configured to collect volatile organic compounds given off from a patient's skin; a wrapping configured to isolate the collector material from an external environment; a heater comprising a heating element, the heating element configured to emit a thermal pulse to desorb the volatile organic compounds from the collector material; and a mesh layer configured to prevent the collector material from contacting the patient's skin, wherein the collector material is received between the wrapping and the mesh layer. |
FILED | Wednesday, April 28, 2021 |
APPL NO | 17/242441 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/443 (20130101) A61B 5/4094 (20130101) Original (OR) Class A61B 5/6831 (20130101) A61B 5/6833 (20130101) A61B 10/00 (20130101) A61B 2010/0083 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/00 (20130101) G01N 30/20 (20130101) G01N 30/64 (20130101) G01N 30/80 (20130101) G01N 2030/025 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322405 | Ding et al. |
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FUNDED BY |
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APPLICANT(S) | Washington University (St. Louis, Missouri); The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts); Battelle Memorial Institute (Richland, Washington) |
ASSIGNEE(S) | |
INVENTOR(S) | Li Ding (St. Louis, Missouri); Song Cao (St. Louis, Missouri); Yige Wu (St. Louis, Missouri); Alla Karpova (St. Louis, Missouri); Liang-Bo Wang (St. Louis, Missouri); Milan Chheda (St. Louis, Missouri); Feng Chen (St. Louis, Missouri); Ramaswamy Govindan (St. Louis, Missouri); Albert Kim (St. Louis, Missouri); Michael Gillette (Boston, Massachusetts); Steven Carr (02142, Massachusetts); Shankha Satpathy (Cambridge, Massachusetts); Tao Liu (Richland, Washington); Karin D. Rodland (Richland, Washington); Richard D. Smith (Richland, Washington) |
ABSTRACT | The present disclosure provides for compositions and methods of treating cancer. In some embodiments, PTPN11 is targeted with and anti-PTPN11 drug, such as a Shp2 inhibitor (e.g., SHP099). In some embodiments, other upregulated, hyperphosphorylated, or hyperacetylated target proteins are inhibited or targeted. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/231273 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/497 (20130101) Original (OR) Class A61K 31/685 (20130101) A61K 31/702 (20130101) A61K 31/4985 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322609 | Bohnert et al. |
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FUNDED BY |
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APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
INVENTOR(S) | George William Bohnert (Harrisonville, Missouri); Darren Radke (Overland Park, Kansas); Domenick Leto (Overland Park, Kansas) |
ABSTRACT | A hydrogen peroxide sterilization device for sterilizing a medical device, the hydrogen peroxide sterilization device including a hermetic outer container, a hydrogen peroxide pouch, and a hydrogen peroxide solution in the solution chamber. The hermetic outer container includes a sterilization enclosure configured to receive the medical device. The hydrogen peroxide pouch includes a permeable membrane enclosing a solution chamber and is configured to be positioned in the sterilization enclosure of the outer container. The permeable membrane is configured to allow hydrogen peroxide vapor to diffuse from the solution chamber through the permeable membrane into the sterilization enclosure. |
FILED | Thursday, September 03, 2020 |
APPL NO | 17/011601 |
CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/208 (20130101) Original (OR) Class A61L 2202/24 (20130101) A61L 2202/122 (20130101) A61L 2202/181 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322909 | Liu et al. |
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FUNDED BY |
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APPLICANT(S) | The Regents of the University of California (Oakland, California) |
ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
INVENTOR(S) | Kai Liu (Falls Church, Virginia); James D. Malloy (Arlington, Virginia) |
ABSTRACT | A metal foam-based filtration system and method for removing sub-micron particles and contaminants from a gas or fluid flow with the use of ultralow density metal nanowire meshes that have nanometer to micron scale pores for trapping air/fluid-borne particulates. Filters can use metal foams and coated metal foams alone or in tandem. The size and density of pores in the foam can be adjusted with synthesis conditions. Foams with pore size gradients promote the trapping of different sized particulates at different regions of a foam. Multiple rounds of electrodeposition may be applied to increase the surface area and curvature of a nanowire mesh and strengthen the mesh to make it self-supporting, free-standing and capable of supporting a much heavier mass without collapse. A metal and/or a coated metal foam can act as a catalyst or substrate for absorption or adsorption to capture target particles and/or contaminants. |
FILED | Thursday, April 29, 2021 |
APPL NO | 17/244796 |
CURRENT CPC | Separation B01D 39/10 (20130101) B01D 39/2051 (20130101) Original (OR) Class B01D 46/0001 (20130101) B01D 46/0026 (20130101) B01D 46/0032 (20130101) B01D 2239/10 (20130101) B01D 2239/0478 (20130101) B01D 2239/1216 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/04 (20130101) C25D 1/006 (20130101) C25D 1/08 (20130101) C25D 7/0607 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322946 | Wegeng et al. |
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FUNDED BY |
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APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
ASSIGNEE(S) | |
INVENTOR(S) | Robert S. Wegeng (Richland, Washington); Paul H. Humble (Kennewick, Washington); Shankar Krishnan (Wilsonville, Oregon); Steven D. Leith (Albany, Oregon); Daniel R. Palo (Chisholm, Minnesota); Robert A. Dagle (Richland, Washington) |
ABSTRACT | A solar thermochemical processing system is disclosed. The system includes a first unit operation for receiving concentrated solar energy. Heat from the solar energy is used to drive the first unit operation. The first unit operation also receives a first set of reactants and produces a first set of products. A second unit operation receives the first set of products from the first unit operation and produces a second set of products. A third unit operation receives heat from the second unit operation to produce a portion of the first set of reactants. |
FILED | Monday, June 28, 2021 |
APPL NO | 17/361213 |
CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/127 (20130101) Original (OR) Class B01J 2219/00006 (20130101) B01J 2219/089 (20130101) B01J 2219/00159 (20130101) B01J 2219/0883 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/48 (20130101) C01B 3/384 (20130101) C01B 2203/061 (20130101) C01B 2203/0233 (20130101) C01B 2203/0283 (20130101) C01B 2203/0445 (20130101) C01B 2203/0855 (20130101) C01B 2203/1288 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 2/30 (20130101) Purifying or Modifying the Chemical Composition of Combustible Gases Containing Carbon Monoxide C10K 3/04 (20130101) Steam Engine Plants; Steam Accumulators; Engine Plants Not Otherwise Provided For; Engines Using Special Working Fluids or Cycles F01K 3/188 (20130101) Methods of Steam Generation; Steam Boilers F22B 1/006 (20130101) Solar Heat Collectors; Solar Heat Systems F24S 20/20 (20180501) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0612 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/40 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/129 (20151101) Y02P 20/133 (20151101) Technical Subjects Covered by Former US Classification Y10T 29/49826 (20150115) Y10T 137/8593 (20150401) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322955 | Schmidt et al. |
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FUNDED BY |
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APPLICANT(S) | W.R. GRACE and CO.- CONN (Columbia, Maryland) |
ASSIGNEE(S) | W.R. GRACE and CO.- CONN (Columbia, Maryland) |
INVENTOR(S) | Stephen R. Schmidt (Silver Spring, Maryland); Cristian Libanati (Silver Spring, Maryland) |
ABSTRACT | A process for preparing a catalyst comprises coating substantial internal surfaces of porous inorganic powders with titanium oxide to form titanium oxide-coated inorganic powders. After the coating, an extrudate comprising the titanium oxide-coated inorganic powders is formed and calcined to form a catalyst support. Then, the catalyst support is impregnated with a solution containing one or more salts of metal selected from the group consisting of molybdenum, cobalt, and nickel. |
FILED | Tuesday, June 29, 2021 |
APPL NO | 17/361825 |
CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/063 (20130101) Original (OR) Class B01J 23/883 (20130101) B01J 23/885 (20130101) B01J 23/8878 (20130101) B01J 23/8993 (20130101) B01J 35/0066 (20130101) B01J 35/1019 (20130101) B01J 35/1038 (20130101) B01J 35/1042 (20130101) B01J 35/1061 (20130101) B01J 37/08 (20130101) B01J 37/0009 (20130101) B01J 37/20 (20130101) B01J 37/0236 (20130101) B01J 37/0242 (20130101) Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes C10G 3/46 (20130101) C10G 3/48 (20130101) C10G 3/50 (20130101) C10G 2300/70 (20130101) C10G 2300/202 (20130101) C10G 2300/207 (20130101) C10G 2300/1014 (20130101) C10G 2400/02 (20130101) C10G 2400/04 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322998 | O'Connor et al. |
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FUNDED BY |
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APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
ASSIGNEE(S) | |
INVENTOR(S) | Megan O'Connor (Guilford, Connecticut); Desiree Plata (Guilford, Connecticut) |
ABSTRACT | The invention provides a novel filtration apparatus for the selective separation of metals from a mixture thereof. The invention also provides a method for the separation and isolation of metals from a sample using electrochemical precipitation. |
FILED | Tuesday, April 27, 2021 |
APPL NO | 17/241520 |
CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/205 (20130101) B01J 20/28026 (20130101) Separating Solid Materials Using Liquids or Using Pneumatic Tables or Jigs B03B 5/00 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/172 (20170801) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) C02F 1/283 (20130101) C02F 1/463 (20130101) C02F 2305/08 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323070 | Nlebedim et al. |
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FUNDED BY |
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APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa); UT-Battlle, LLC (Oak Ridge, Tennessee) |
ASSIGNEE(S) | Iowa State University Research Foundation, Inc. (, None); UT-Battlle, LLC (, None) |
INVENTOR(S) | Cajetan Ikenna Nlebedim (Ames, Iowa); Abhishek Sarkar (Ames, Iowa); Matthew J. Kramer (Ankeny, Iowa); Thomas Lograsso (Ames, Iowa); Christopher Haase (Cedar Park, Texas); Somashekara Adinarayanappa (Karnataka, India); Mariappan Parans Paranthaman (Knoxville, Tennessee) |
ABSTRACT | Embodiments of the present invention provide an electromagnet alignment system for AM or 3D printing technology providing improved in-situ alignment of the magnetic particulate material as it is dispensed during deposition to form a 3D shape. In-situ alignment of the magnetic particulate material can be controlled to be unidirectional or multi-directional. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/300213 |
CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/34 (20210101) Original (OR) Class B22F 12/53 (20210101) B22F 2202/05 (20130101) B22F 2302/25 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323072 | Paranthaman et al. |
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FUNDED BY |
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APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
ASSIGNEE(S) | |
INVENTOR(S) | Mariappan Parans Paranthaman (Knoxville, Tennessee); Brian K. Post (Knoxville, Tennessee); Brian C. Sales (Lenoir City, Tennessee) |
ABSTRACT | An electromagnet alignment system for in-situ alignment of a magnetic particulate material is provided. The magnetic particulate material is dispensed through an orifice of a dispensing nozzle used for 3D printing. The system has an electromagnet assembly having a coil. The coil is configured to generate a pulsed magnetic field having a target magnetic flux intensity upon energization of the coil when the magnetic particulate material is being heated and moved through the dispensing nozzle. As a result, the magnetic particulate material is at least partially aligned with respect to a direction by the pulsed magnetic field. The system further includes a power source for implementing the energization of the coil. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/231498 |
CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0059 (20130101) B22F 10/34 (20210101) B22F 10/85 (20210101) B22F 12/13 (20210101) B22F 12/53 (20210101) Original (OR) Class B22F 12/90 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 50/02 (20141201) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323201 | LOJEK, III et al. |
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FUNDED BY |
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APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
ASSIGNEE(S) | |
INVENTOR(S) | John LOJEK, III (Valencia, Pennsylvania); Matthew M. SWARTZ (Claridge, Pennsylvania); William A. BYERS (Murrysville, Pennsylvania) |
ABSTRACT | A forming assembly configured to form a wick is disclosed. The forming assembly includes an expandable tube and a forming shell assembly. The expandable tube is hydraulically expandable to an expanded configuration. A wick mesh is configured to be wrapped about the expandable tube. The forming shell assembly includes a first forming shell comprising a first recess defined therein and a second forming shell comprising a second recess defined therein. The first recess and the second recess cooperate to define an outer diameter of the wick. The expandable tube and the wick mesh are positionable between the first recess and the second recess. The expandable tube and the forming shell assembly are configured to deform the wick mesh and form the wick based on the expandable tube hydraulically expanding towards the expanded configuration. |
FILED | Monday, April 20, 2020 |
APPL NO | 16/853270 |
CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 43/10 (20130101) Original (OR) Class B29C 43/3642 (20130101) B29C 2043/3602 (20130101) B29C 2043/3649 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/18 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323963 | Li et al. |
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FUNDED BY |
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APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
ASSIGNEE(S) | |
INVENTOR(S) | Jian Li (Tempe, Arizona); Xinqiang Tan (Tempe, Arizona) |
ABSTRACT | A series of novel donor-acceptor type TADF luminogens have been designed with the aim of developing stable OLEDs with enhanced operational stability and improved color purity. These materials can be utilized in full color displays and lighting applications. |
FILED | Thursday, February 18, 2021 |
APPL NO | 17/178901 |
CURRENT CPC | Heterocyclic Compounds C07D 471/22 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0072 (20130101) H01L 51/5016 (20130101) H01L 2251/552 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324217 | Mabe et al. |
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FUNDED BY |
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APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Andrew Neil Mabe (Livermore, California); Jason Brodsky (Livermore, California); Elaine Lee (Brooklyn, New York); Jeremy Lenhardt (Tracy, California); Dominique Henry Porcincula (Oakland, California); Xianyi Zhang (Newark, California) |
ABSTRACT | An ink for forming a scintillator product includes a phenylated siloxane polymer having at least one functional group per molecule for crosslinking, a filler having a refractive index about matching a refractive index of the phenylated siloxane polymer, where the refractive indices are within about 5% of one another, a rheology modifier, and at least one fluorescent dye. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/232521 |
CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2083/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/037 (20130101) C09D 11/50 (20130101) Original (OR) Class C09D 11/102 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/02 (20130101) Measurement of Nuclear or X-radiation G01T 1/2018 (20130101) G01T 1/2033 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324245 | Zhang et al. |
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FUNDED BY |
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APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Yuepeng Zhang (Naperville, Illinois); John N. Hryn (Hawthorn Woods, Illinois) |
ABSTRACT | A method for fabricating, and curing, nanocomposite adhesives including introducing nanoheater elements into a heat-curing adhesive to fabricate a nanocomposite adhesive, and providing a radio-frequency (RF) electromagnetic wave to the nanocomposite adhesive to heat, and cure the nanocomposite adhesive. The nanocomposite adhesive is physically applied to first and second materials to bond the first and second materials upon curing of the nanocomposite adhesive, and the RF electromagnetic wave has a frequency in the radio-frequency range, having energy that is transferred to the nanoheater elements by electromagnetic wave interactions with permanent and induced dipoles, intrinsic photon-phonon interaction, or interactions with nanoheater defects and grain structures. |
FILED | Monday, April 20, 2020 |
APPL NO | 16/853049 |
CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 5/06 (20130101) C09J 11/04 (20130101) Original (OR) Class C09J 163/00 (20130101) C09J 2205/30 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324351 | Kranzusch et al. |
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FUNDED BY |
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APPLICANT(S) | Presodent and Fellows of Harvard College (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Philip J. Kranzusch (Bringhton, Massachusetts); John J. Mekalanos (Newton, Massachusetts); Aaron T. Whiteley (Brookline, Massachusetts); Wen Zhou (Boston, Massachusetts) |
ABSTRACT | The present invention is based, in part, on the discovery of the human-specific regulatory control of cGAS and the structure of the active human cGAS-DNA complex, as well as compositions comprising the modified hcGAS polypeptide, hcGAS-DNA complex, hcGAS-DNA-ATP complex, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides and complexes. |
FILED | Wednesday, June 26, 2019 |
APPL NO | 17/252454 |
CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1241 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324425 | Doktycz et al. |
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FUNDED BY |
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APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
ASSIGNEE(S) | |
INVENTOR(S) | Mitchel J. Doktycz (Oak Ridge, Tennessee); Jaime Lorenzo N Dinglasan (Oak Ridge, Tennessee); David Garcia (Oak Ridge, Tennessee); Ben P. Mohr (Oak Ridge, Tennessee) |
ABSTRACT | The present disclosure is directed to methods for proteome engineering cells such that cell-free extracts prepared from such engineered cells can be modified to have metabolic flux directed to a metabolism of interest. In addition, methods for producing cell-free extracts with directed metabolism, cell-free extracts and kits that contain cell-free extracts are also disclosed. |
FILED | Tuesday, April 20, 2021 |
APPL NO | 17/235450 |
CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/06 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/06 (20130101) C12P 7/22 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324500 | RIOS et al. |
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FUNDED BY |
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APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); Eck Industries, Inc. (Manitowoc, Wisconsin) |
ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); Eck Industries, Inc. (Manitowoc, Wisconsin) |
INVENTOR(S) | Orlando RIOS (Knoxville, Tennessee); David WEISS (Manitowoc, Wisconsin); Zachary C. SIMS (Knoxville, Tennessee); William G. CARTER (Oak Ridge, Tennessee); Michael S. KESLER (Knoxville, Tennessee) |
ABSTRACT | An alloy for structural direct-writing additive manufacturing comprising a base element selected from the group consisting of aluminum (Al), nickel (Ni) and a combination thereof, and a rare earth element selected from the group consisting of cerium (Ce), lanthanide (La) and a combination thereof, and a eutectic intermetallic present in said alloy in an amount ranging from about 0.5 wt. % to 7.5 wt. %. The invention is also directed to a method of structural direct-write additive manufacturing using the above-described alloy, as well as 3D objects produced by the method. The invention is also directed to methods of producing the above-described alloy. |
FILED | Tuesday, June 29, 2021 |
APPL NO | 17/361485 |
CURRENT CPC | Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 23/003 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Alloys C22C 21/00 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324540 | Bidhar |
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FUNDED BY |
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APPLICANT(S) | FERMI RESEARCH ALLIANCE, LLC (BATAVIA, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Sujit Bidhar (Carol Stream, Illinois) |
ABSTRACT | Systems and methods for creating coating a substrate with nanofiber comprise a dual polarity high voltage power supply, a first wire for wire electrospinning held at positive potential by the power supply, a second wire held at negative potential by the power supply and a spooling system for drawing a substrate between the first wire and the second wire. A slider and a solution chamber in fluidic connection with the slider are used to slide along the first wire delivering solution to the wire. |
FILED | Wednesday, April 21, 2021 |
APPL NO | 17/236983 |
CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/11 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2321/042 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324743 | Hart et al. |
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FUNDED BY |
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APPLICANT(S) | General Electric Company (Schenectady, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Andrew Clifford Hart (Greenville, South Carolina); John McConnell Delvaux (Fountain Inn, South Carolina); Joseph Anthony Weber (Simpsonville, South Carolina); James Zhang (Simpsonville, South Carolina); Peter de Diego (Zirconia, North Carolina) |
ABSTRACT | An article, such as a turbine blade, includes an airfoil. The airfoil includes a body, the body having an elongated internal cavity extending from a tip of the body. The cavity is defined an internal wall within the body. At least one elongated damping element is disposed in the elongated internal cavity and frictionally engages the internal wall. Thus, the least one elongated damping element is capable of damping vibrations in the article. |
FILED | Friday, April 17, 2020 |
APPL NO | 16/851629 |
CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/16 (20130101) Original (OR) Class F01D 5/26 (20130101) F01D 5/147 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324754 | Sarawate et al. |
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FUNDED BY |
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APPLICANT(S) | General Electric Company (Schenectady, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Neelesh Nandkumar Sarawate (Niskayuna, New York); Jonathan Dwight Berry (Simpsonville, South Carolina); Russell Pierson DeForest (Simpsonville, South Carolina); Kevin Weston McMahan (Greenville, South Carolina); Victor John Morgan (Simpsonville, South Carolina); Ibrahim Klara Sezer (Greenville, South Carolina); Deepak Trivedi (Halfmoon, New York) |
ABSTRACT | A flexible seal for sealing between two adjacent gas turbine components includes a forward end, an aft end axially separated from the forward end, and an intermediate portion between the forward end and the aft end. The intermediate portion defines a continuous curve in the circumferential direction, such that the aft end is circumferentially offset from the forward end. In other cases, the forward and aft ends are axially, radially, and circumferentially offset from one another. A method of sealing using the flexible seal includes inserting, in an axial direction, the aft end of the flexible seal into a recess defined by respective seal slots of two adjacent gas turbine components; and pushing the flexible seal in an axial direction through the recess until the forward end is disposed within the recess. |
FILED | Friday, June 25, 2021 |
APPL NO | 17/358691 |
CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/005 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/35 (20130101) F05D 2240/55 (20130101) Pistons; Cylinders; Sealings F16J 15/0887 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/46 (20130101) F23R 2900/00012 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325038 | Gao et al. |
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FUNDED BY |
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APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
ASSIGNEE(S) | |
INVENTOR(S) | Zhiming Gao (Oak Ridge, Tennessee); Ayyoub M. Momen (Oak Ridge, Tennessee); Josh A. Pihl (Oak Ridge, Tennessee); Timothy J. LaClair (Oak Ridge, Tennessee); Bo Shen (Oak Ridge, Tennessee); Xiaobing Liu (Oak Ridge, Tennessee); Kyle R. Gluesenkamp (Oak Ridge, Tennessee); James E. Parks, II (Oak Ridge, Tennessee); Puxian Gao (Oak Ridge, Tennessee); Alex E. Pawlowski (Oak Ridge, Tennessee); Kashif Nawaz (Oak Ridge, Tennessee) |
ABSTRACT | An improved method and system for treating flue gases from a natural gas furnace are provided. The method and system include an acidic gas trap (AGT) adsorber which enables the continuous adsorption and storage of SOx, NOx redox, and formic acid/CO/HC/CH4 oxidation, with a negligible pressure drop. The AGT adsorber includes a catalyst coating having a nanotube structure (e.g., a uniform nanostructure forest coating) or a uniform porous nanostructure of various low-cost oxides through scalable low temperature solution processes, including oxides of Ti, Cu, Ba, Mn, Zr, Zn, Sr, Ca, Li, K, Na, Al, or Ce. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/232274 |
CURRENT CPC | Removal or Treatment of Combustion Products or Combustion Residues; Flues F23J 3/04 (20130101) Original (OR) Class F23J 15/02 (20130101) F23J 2215/10 (20130101) F23J 2215/20 (20130101) F23J 2900/15022 (20130101) Indexing Scheme Relating to Aspects of the Charges or Furnaces, Kilns, Ovens or Retorts F27M 2003/165 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325072 | LIN et al. |
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FUNDED BY |
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APPLICANT(S) | Robert Bosch GmbH (Stuttgart, Germany) |
ASSIGNEE(S) | |
INVENTOR(S) | Shan LIN (Jericho, New York); Sirajum MUNIR (Pittsburgh, Pennsylvania) |
ABSTRACT | A thermal state of a plurality of zones of the building is updated according to a building thermal model and information received from temperature sensors of the building. Predicted occupant counts for an upcoming plurality of time slots for each of the plurality of zones are updated using actual occupancy counts for each of the plurality of zones. A misprediction type distribution for the upcoming plurality of time slots for each of the plurality of zones is updated, the misprediction type distribution indicating misprediction for true negatives, false positives, false negatives, and true positives. A total misprediction cost expectation is updated according to the predicted occupant counts and the misprediction type distribution. HVAC power for each of the plurality of zones is determined to optimize occupant thermal comfort weighted according to the predicted occupant counts while minimizing the total misprediction cost expectation. HVAC operation is controlled per the HVAC power. |
FILED | Thursday, April 16, 2020 |
APPL NO | 16/850860 |
CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/47 (20180101) F24F 11/48 (20180101) F24F 11/65 (20180101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325122 | SWARTZ et al. |
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APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
INVENTOR(S) | Matthew M. SWARTZ (Claridge, Pennsylvania); William A. BYERS (Murrysville, Pennsylvania); John LOJEK, III (Valencia, Pennsylvania) |
ABSTRACT | A heat pipe is disclosed includes a container, a container lid including a groove defined therein, a wick, and an end plug operably coupled to the wick. The end plug includes a pin extending therefrom. The groove of the container lid is configured to receive the pin. |
FILED | Monday, April 20, 2020 |
APPL NO | 16/853345 |
CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/046 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325124 | KLAUSNER et al. |
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APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
INVENTOR(S) | James F. KLAUSNER (Haslett, Michigan); Joerg PETRASCH (East Lansing, Michigan); Kelvin RANDHIR (East Lansing, Michigan); Nima RAHMATIAN (East Lansing, Michigan) |
ABSTRACT | Systems and methods for energy storage and energy recovery are provided. An electrical-to-electrical energy storage system includes a thermochemical energy storage device, a blower, a compressor, a turbine, and an electrical generator. The TCES device includes a vessel, a porous bed, and a heater. The porous bed is disposed within an interior volume of the vessel. The porous bed comprises a reactive material. The reactive material is configured to release oxygen upon being heated to a reduction temperature, and generate heat when exposed to oxygen. The heater is in thermal contact with the reactive material. The blower is configured to remove oxygen from the interior volume. The compressor is configured to flow oxygen into the interior volume. The turbine is configured to receive a heated, oxygen-depleted gas from the interior volume. The generator is configured to be powered by the turbine to generate electricity. |
FILED | Wednesday, June 30, 2021 |
APPL NO | 17/363541 |
CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 7/024 (20130101) F28D 20/003 (20130101) Original (OR) Class F28D 2020/0017 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325428 | Ovchinnikova et al. |
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APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
ASSIGNEE(S) | |
INVENTOR(S) | Olga S. Ovchinnikova (Oak Ridge, Tennessee); Nikolay Borodinov (Oak Ridge, Tennessee); Anton V. Ievlev (Oak Ridge, Tennessee); Sergei V. Kalinin (Oak Ridge, Tennessee); Rama K. Vasudevan (Oak Ridge, Tennessee) |
ABSTRACT | Techniques for generating full-spatial resolution, full spectral resolution image(s) from a 3D spectral-data cube for any spectral value within a given spectral range are provided without requiring the acquisition of all full-spatial resolution, full spectral resolution data by an instrument. The 3D spectral-data cube is generated from a limited number of full-spatial resolution, sparse spectral resolution data and a sparse-spatial resolution, full-spectral resolution data of the same area of the sample. The use of the 3D spectral-data cube reduces the data acquisition time. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/232774 |
CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/2258 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 30/04 (20130101) Original (OR) Class G01Q 60/24 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325459 | Hanna et al. |
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APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (KANSAS CITY, Missouri) |
ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (KANSAS CITY, Missouri) |
INVENTOR(S) | Charles John Hanna (Gardner, Kansas); Tuan N. Nguyen (Olathe, Kansas); Will Schulte Plamann (Leawood, Kansas) |
ABSTRACT | A method of testing a PIN diode for a power limiter circuit comprises measuring a reverse bias current of the PIN diode; applying a reverse bias voltage to the PIN diode; increasing the reverse bias voltage until the reverse bias current of the PIN diode reaches a threshold current indicative of a reverse voltage breakdown; and determining whether the reverse bias breakdown voltage of the PIN diode is within an acceptable range of reverse bias breakdown voltages corresponding to a power range at which the power limiter circuit would enter power limiting mode with the PIN diode. |
FILED | Friday, April 17, 2020 |
APPL NO | 16/851328 |
CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/31713 (20130101) Original (OR) Class Control of Amplification H03G 11/02 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325560 | Jones et al. |
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APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
INVENTOR(S) | A. Mark Jones (West Richland, Washington); David M. Sheen (Richland, Washington); Stanley L. Owsley, JR. (Pasco, Washington) |
ABSTRACT | Footwear scanning systems and associated methods are described. According to one aspect, a footwear scanning system includes a base, a shuttle configured to rotate beneath the base, wherein the shuttle comprises an antenna array configured to transmit electromagnetic waves through the base into footwear above the base during the rotation of the shuttle and to receive electromagnetic waves reflected from the footwear during the rotation of the shuttle, a transceiver coupled with the antenna array and configured to apply electrical signals to the antenna array to generate the transmitted electromagnetic waves and to receive electrical signals from the antenna array corresponding to the received electromagnetic waves, and processing circuitry configured to process an output of the transceiver corresponding to the received electromagnetic waves to provide information regarding contents within the footwear. |
FILED | Friday, June 05, 2020 |
APPL NO | 16/894484 |
CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 22/00 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 3/12 (20130101) Original (OR) Class Transmission H04B 1/38 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210326171 | Riesen et al. |
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APPLICANT(S) | Intel Corporation (Santa Clara, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Rolf Riesen (Forest Grove, Oregon); Robert Wisniewski (Ossining, New York); Rajesh Poornachandran (Portland, Oregon) |
ABSTRACT | Methods, apparatus, systems, and articles of manufacture are disclosed to relocate a compute thread, the apparatus comprising control circuitry to maintain a location of a plurality of domain access counters associated with a plurality of compute-memory domains for a first compute thread, and an execution monitor to set a first domain access counter of the plurality of domain access counters, the first domain access counter associated with a first compute-memory domain of the compute-memory domains, and relocate the first compute thread to a second compute-memory domain of the compute-memory domains in response to a comparison between a second domain access counter associated with the second compute-memory domain and the first domain access counter. |
FILED | Saturday, June 26, 2021 |
APPL NO | 17/359504 |
CURRENT CPC | Electric Digital Data Processing G06F 9/321 (20130101) G06F 9/4856 (20130101) Original (OR) Class G06F 9/5038 (20130101) G06F 9/30101 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210326499 | Martin et al. |
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APPLICANT(S) | BWXT mPower, Inc. (Charlotte, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Robert P. Martin (Lynchburg, Virginia); Simone H. Morgan (Lynchburg, Virginia) |
ABSTRACT | An apparatus and method for system safety analysis evaluation is provided, the apparatus including processing circuitry configured for generating a calculation matrix for a system, generating a plurality of models based on the calculation matrix, performing a benchmarking or convolution analysis of the plurality of models, identifying a design envelope based on the benchmarking or convolution analysis, deriving uncertainty models from the benchmarking or convolution analysis, deriving an assessment judgment based on the uncertainty models and acceptance criteria, defining one or more limiting scenarios based on the design envelope, and determining a safety margin in at least one figure-of-merit for the system based on the design envelope and the acceptance criteria. |
FILED | Monday, April 26, 2021 |
APPL NO | 17/240813 |
CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210326644 | Suski et al. |
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APPLICANT(S) | Applied Engineering Concepts, Inc. (Eldersburg, Maryland) |
ASSIGNEE(S) | |
INVENTOR(S) | William Charles Suski (Mount Pleasant, South Carolina); Christopher Alan Card (Sykesville, Maryland); Brian Richard Few (Sykesville, Maryland) |
ABSTRACT | A network authentication system can be configured for sampling a plurality of signal samples from a device on a network, providing the plurality of signal samples to a first machine-learned model that is configured to determine a device fingerprint based at least in part on the plurality of signal samples, and providing the device fingerprint to a second machine-learned model that is configured to classify the device based at least in part on the device fingerprint. |
FILED | Wednesday, February 17, 2021 |
APPL NO | 17/177513 |
CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/626 (20130101) G06K 9/6256 (20130101) Original (OR) Class G06K 9/6269 (20130101) Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327599 | Hayes et al. |
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APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Robert Bruce Hayes (Clayton, North Carolina); Michael Jeffrey DeVanzo (Coatesville, Pennsylvania) |
ABSTRACT | Conformal coatings provide environmental protection for sensitive military electronics. Preliminary MCNP™ modeling of metal oxide impregnated acrylic conformal coatings indicates an effective shield for gammas below 10 keV and a reduction in neutron displacement damage to Si-based electronics across the Watt spectrum. This work provides data which can allow an optimal overall shielding worth per total weight to eventually be evaluated. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/233312 |
CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/10 (20200101) B33Y 80/00 (20141201) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 167/07 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 1/08 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 9/0081 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327602 | BROWN et al. |
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APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
INVENTOR(S) | Michael A. BROWN (Chicago, Illinois); David J. BETTINARDI (Chicago, Illinois); Peter TKAC (Naperville, Illinois) |
ABSTRACT | A method for separating a parent isotope from a daughter isotope is provided, the method comprising supplying irradiated target; dissolving the irradiated target; treating the dissolved irradiated target to a precipitation step to form a first solid phase of the parent isotope and a first liquid phase of the daughter isotope; filtering the first liquid phase of daughter isotope to create a first purified fraction of the daughter isotope to create a second solid phase of the parent isotope and a second liquid phase of the daughter isotope; and filtering the second liquid phase to create a second liquid fraction of the daughter isotope. The process can be repeated until the 99Mo is exhausted and the enriched target material 98Mo or 100Mo can be easily re-used. |
FILED | Thursday, April 16, 2020 |
APPL NO | 16/850783 |
CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 1/001 (20130101) Original (OR) Class G21G 2001/0042 (20130101) G21G 2001/0073 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 6/00 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327614 | Susan et al. |
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FUNDED BY |
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APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Deringer-Ney, Inc. (Bloomfield, Connecticut) |
ASSIGNEE(S) | |
INVENTOR(S) | Donald F. Susan (Albuquerque, New Mexico); Zahra Ghanbari (Albuquerque, New Mexico); Steve Xunhu Dai (Albuquerque, New Mexico); Brenton Elisberg (Albuquerque, New Mexico); Edward F. Smith, III (Madison, Connecticut); Patrick K. Bowen (Windsor, Connecticut) |
ABSTRACT | A combination of materials and processing parameters have been developed for hermetic seals for electrical feedthroughs in high performance applications. A glass-ceramic forms a hermetic seal between a stainless steel shell and a platinum-nickel-based (Pt—Ni) pin alloy for electrical feedthroughs. The glass-ceramic is processed to develop a coefficient of thermal expansion (CTE) slightly higher than the pin alloy but lower than the stainless steel. The seal system employing the new processing conditions and Pt—Ni-based pin alloy alleviates several problems encountered in previous seal systems and improves the hermetic connector performance. |
FILED | Monday, April 12, 2021 |
APPL NO | 17/227965 |
CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 27/02 (20130101) Alloys C22C 5/04 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 17/305 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327615 | Podpaly et al. |
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APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Yuri Anatoly Podpaly (Hayward, California); Michael Gordon Anderson (Discovery Bay, California); Steve Hawkins (Livermore, California); Alexander Peter Povilus (Livermore, California); Chris Vice (Livermore, California) |
ABSTRACT | High-voltage insulators are disclosed that are capable of handling diverse requirements, such as providing high standoff voltages, high temperature cycling, and the ability to withstand flexural stress. One high-voltage insulator includes a first piece formed from a first material, a second piece formed from a second material, and an interface section where the first piece contacts with and forms a seal with the second piece. The interface includes a first groove located that accommodates a first gasket, sets of matching threads on the first and second pieces. The interface section further accommodates a second gasket. In this multi-piece high-voltage insulator, the first material can have a first set of flexural, heat resistance, and electrical standoff characteristics suitable for a first environment, and the second material can have a second set of flexural, heat resistance and electrical standoff characteristics suitable for a second environment. |
FILED | Tuesday, April 13, 2021 |
APPL NO | 17/229487 |
CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 17/44 (20130101) H01B 17/305 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327655 | Brambilla |
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FUNDED BY |
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APPLICANT(S) | FastCAP Systems Corporation (Boston, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Nicolo Brambilla (Brookline, Massachusetts) |
ABSTRACT | An ultracapacitor that includes an energy storage cell immersed in an electrolyte and disposed within an hermetically sealed housing, the cell electrically coupled to a positive contact and a negative contact, wherein the ultracapacitor has a gel or polymer based electrolyte and is configured to output electrical energy at temperatures between about −40° C. and about 250° C. Methods of fabrication and use are provided. |
FILED | Tuesday, December 22, 2020 |
APPL NO | 17/129976 |
CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/24 (20130101) H01G 11/36 (20130101) H01G 11/52 (20130101) H01G 11/56 (20130101) Original (OR) Class H01G 11/62 (20130101) H01G 11/64 (20130101) H01G 11/68 (20130101) H01G 11/70 (20130101) H01G 11/80 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/13 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328057 | Conway et al. |
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APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Adam Conway (Livermore, California); Sara Elizabeth Harrison (Fremont, California); Rebecca Nikolic (Oakland, California); Qinghui Shao (Fremont, California); Lars Voss (Livermore, California) |
ABSTRACT | An apparatus includes at least one vertical transistor, where the at least one vertical transistor includes: a substrate including a first semiconductor material, an array of three dimensional (3D) structures above the substrate, a sidewall heterojunction layer positioned on at least one vertical sidewall of each 3D structure, and an isolation region positioned between the 3D structures. Each 3D structure includes the first semiconductor material. The sidewall heterojunction layer includes a second semiconductor material, where the first and second semiconductor material have different bandgaps. |
FILED | Thursday, April 22, 2021 |
APPL NO | 17/238012 |
CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/205 (20130101) H01L 29/0657 (20130101) H01L 29/2003 (20130101) H01L 29/7788 (20130101) H01L 29/7789 (20130101) H01L 29/7827 (20130101) Original (OR) Class H01L 29/8083 (20130101) H01L 29/66924 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328086 | Hubbard et al. |
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APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
INVENTOR(S) | Lance R. Hubbard (Richland, Washington); Gary J. Sevigny (Richland, Washington); Radha K. Motkuri (Richland, Washington) |
ABSTRACT | A beta-voltaic device made up of silica covered scintillating particles incorporated within an isotope absorbing layer to produce an improved power source. Lost beta particles are converted to UV light which is also converted to power in a beta-voltaic converter. The addition of the scintillating particles effectively increases the power efficiency of a BV device while maintaining the slim profile and smaller size of the power source. This arrangement makes possible implementation in space, defense, intelligence, medical implants, marine biology and other applications. |
FILED | Friday, March 19, 2021 |
APPL NO | 17/206469 |
CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/025 (20130101) C09K 11/616 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/055 (20130101) Original (OR) Class H01L 31/0693 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328093 | Pan et al. |
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FUNDED BY |
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APPLICANT(S) | MICROLINK DEVICES, INC. (Niles, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Noren Pan (Wilmette, Illinois); Glen Hillier (Spring Grove, Illinois); Duy Phach Vu (San Jose, California); Rao Tatavarti (Mount Prospect, Illinois); Christopher Youtsey (Libertyville, Illinois); David McCallum (West Chicago, Illinois); Genevieve Martin (Chicago, Illinois) |
ABSTRACT | The present invention utilizes epitaxial lift-off in which a sacrificial layer is included in the epitaxial growth between the substrate and a thin film III-V compound solar cell. To provide support for the thin film III-V compound solar cell in absence of the substrate, a backing layer is applied to a surface of the thin film III-V compound solar cell before it is separated from the substrate. To separate the thin film III-V compound solar cell from the substrate, the sacrificial layer is removed as part of the epitaxial lift-off. Once the substrate is separated from the thin film III-V compound solar cell, the substrate may then be reused in the formation of another thin film III-V compound solar cell. |
FILED | Monday, February 08, 2021 |
APPL NO | 17/170133 |
CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/1844 (20130101) H01L 31/1852 (20130101) Original (OR) Class H01L 31/1896 (20130101) H01L 31/06875 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328210 | JOHNSON et al. |
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APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Christopher S. JOHNSON (Naperville, Illinois); Eungje LEE (Naperville, Illinois); Jinhyup HAN (Woodridge, Illinois); Jehee Park (Woodridge, Illinois) |
ABSTRACT | Lead/lead oxide/carbon (“Pb—O—C”) nanocomposite materials are useful as electrode active materials for electrodes in lithium and sodium batteries. A Pb—O—C nanocomposite as described herein comprises Pb and PbOx nanoparticles homogeneously dispersed in a carbon nanoparticle matrix. In the Nanocomposite, the other element or elements (e.g., transition metals, Al, Si, P, Sn, Sb, and Bi) can be alloyed with the Pb nanoparticles, incorporated as a mixed oxide with the PbOx nanoparticles, or can be present as distinct elemental or oxide nanoparticles within the carbon nanoparticle matrix. In some embodiments, the additional element or elements are present as alloys and mixed oxides with the Pb materials and as distinct elemental and/or oxide nanoparticles. In a preferred embodiment the Pb nanoparticles surface is oxidized to PbOx thus creating a shell on core nanostructure. |
FILED | Tuesday, April 21, 2020 |
APPL NO | 16/853988 |
CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/57 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 10/054 (20130101) H01M 10/0525 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328257 | MAUGHAN |
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FUNDED BY |
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APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
ASSIGNEE(S) | |
INVENTOR(S) | Annalise Elizabeth MAUGHAN (Westminster, Colorado) |
ABSTRACT | Disclosed herein are new argyrodite compositions of matter, including, for example, Li6PS5CN, and methods for making the same. |
FILED | Thursday, March 18, 2021 |
APPL NO | 17/206100 |
CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328319 | Krueger |
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FUNDED BY |
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APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
INVENTOR(S) | Daniel Scott Krueger (Liberty, Missouri) |
ABSTRACT | Waveguides and methods for manufacturing a waveguide that include forming a first channel in a first layer of dielectric material, the first channel comprising one or more walls; forming a second channel in a second layer of dielectric material, the second channel comprising one or more walls; depositing electrically conductive material on the one or more walls of the first channel; depositing electrically conductive material on the one or more walls of the second channel; arranging the first layer adjacent to the second layer to form a stack with the first channel axially aligned with and facing the second channel; and heating the stack so that the conductive material on the one or more walls of the first channel and the conductive material on the one or more walls of the second channel connect to form the waveguide. |
FILED | Friday, April 17, 2020 |
APPL NO | 16/851486 |
CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/16 (20130101) H01P 3/121 (20130101) Original (OR) Class H01P 11/006 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328431 | Zhan et al. |
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APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
ASSIGNEE(S) | |
INVENTOR(S) | Lingwei Zhan (Oak Ridge, Tennessee); Thomas J. King, JR. (Oak Ridge, Tennessee); Fuhua Li (Oak Ridge, Tennessee); Yilu Liu (Oak Ridge, Tennessee); Wenxuan Yao (Oak Ridge, Tennessee); He Yin (Oak Ridge, Tennessee); Bailu Xiao (Oak Ridge, Tennessee) |
ABSTRACT | A system determines the frequency of grid signals corresponding to an electrical grid in real time. The system includes a transient detector that monitors a grid signal from a voltage meter or a current meter connected to the electrical grid. The system produces, in real time and at a sampling rate, a deviation signal indicative of a periodicity of the monitored grid signal. The system determines, over one or more cycles of the monitored grid signal, a measurement signal corresponding to the deviation signal. The system determines a frequency signal that corresponds a frequency estimation of the monitored signal by applying a frequency estimation when values of the measurement signal are less than a deviation threshold and maintaining the frequency signal at a constant value when values of the measured signal equal or exceeds the deviation threshold. |
FILED | Wednesday, March 17, 2021 |
APPL NO | 17/204494 |
CURRENT CPC | Electric Digital Data Processing G06F 17/14 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/003 (20200101) H02J 3/004 (20200101) H02J 3/46 (20130101) H02J 3/144 (20200101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210329061 | Grant et al. |
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APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
ASSIGNEE(S) | |
INVENTOR(S) | Ryan Grant (Albuquerque, New Mexico); William Whitney Schonbein (Albuquerque, New Mexico) |
ABSTRACT | A method and apparatus for performing operations by network interface cards in a network of computers. A network interface card is configured to receive a message and to interpret the message to identify a primitive operation to be performed. The primitive operation is one of a plurality of primitive operations that are performed to perform an operation. The primitive operation is performed by the network interface card and a trigger signal is generated in response to performing the primitive operation. The trigger signal is interpreted to identify a triggered message. The triggered message identifies a next one of the plurality of primitive operations to be performed. The triggered message is transmitted back to the network interface card or to another network interface card in the network for processing. |
FILED | Thursday, April 16, 2020 |
APPL NO | 16/850994 |
CURRENT CPC | Electric Digital Data Processing G06F 9/5011 (20130101) G06F 2209/509 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/10 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210329751 | OHODNICKI, JR. et al. |
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FUNDED BY |
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APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania); United States Department Of Energy (Washington, District of Columbia) |
ASSIGNEE(S) | |
INVENTOR(S) | Paul R. OHODNICKI, JR. (Allison Park, Pennsylvania); Kevin BYERLY (Pittsburgh, Pennsylvania); Dinesh AGRAWAL (State College, Pennsylvania); Michael LANAGAN (State College, Pennsylvania) |
ABSTRACT | Methods and systems including a microwave radiation source are described. A first region of a pure magnetic field can be generated in a first processing zone using a microwave radiation source of the first processing zone. The first processing zone can be a single mode microwave radiation chamber. A second region of a pure electric field can be generated in the first processing zone using the microwave radiation source. The second region can be spatially distinct from the first region. A first portion of an amorphous alloy can be loaded automatically into the first processing zone. The first portion can be positioned in an annealing region. The annealing region can be a single field region selected from the first region and the second region. The first portion can be heated in the annealing region. The first portion can be automatically unloaded from the first processing zone. |
FILED | Wednesday, June 19, 2019 |
APPL NO | 17/254163 |
CURRENT CPC | Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering C21D 1/26 (20130101) C21D 1/34 (20130101) C21D 11/00 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/00 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/68 (20130101) H05B 6/80 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
US 20210321576 | ZHANG et al. |
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FUNDED BY |
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APPLICANT(S) | WASHINGTON STATE UNIVERSITY (Pullman, Washington) |
ASSIGNEE(S) | |
INVENTOR(S) | Xiao ZHANG (Richland, Washington); Changki MO (Richland, Washington); Matthew David WHITING (Prosser, Washington); Qin ZHANG (Richland, Washington) |
ABSTRACT | Compositions and methods of protecting plants from cold damage are provided. In particular, the invention provides compositions comprising plant-based nano- and/or micron-sized particles which, when applied to plants or plant parts such as buds, form a non-hydrophilic deposit or film with low thermal conductivity, thereby conferring protection against damage from ice nucleation and cold stress. |
FILED | Monday, June 28, 2021 |
APPL NO | 17/359727 |
CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 13/065 (20130101) Original (OR) Class Processes for Applying Fluent Materials to Surfaces, in General B05D 1/02 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 105/14 (20130101) C09D 197/02 (20130101) C09D 197/005 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210321623 | White et al. |
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FUNDED BY |
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APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); U.S. Geological Survey (Ann Arbor, Michigan) |
ASSIGNEE(S) | |
INVENTOR(S) | James F. White (New Brunswick, New Jersey); Kurt P. Kowalski (Ann Arbor, Michigan); Kathryn L. Kingsley (Robbinsville, New Jersey); Matthew T. Elmore (East Brunswick, New Jersey) |
ABSTRACT | Endophytic bacteria, compositions comprising the same, and methods of use thereof are disclosed which suppress growth of aggressive, invasive weed species which grow in the same habitat of target plants of interest. |
FILED | Friday, August 09, 2019 |
APPL NO | 17/266489 |
CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/27 (20200101) Original (OR) Class A01N 63/32 (20200101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210321624 | SHAPIRO ILAN et al. |
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FUNDED BY |
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APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (Athens, Georgia) |
ASSIGNEE(S) | |
INVENTOR(S) | DAVID I. SHAPIRO ILAN (MACON, Georgia); ROBERT W. BEHLE (MORTON, Illinois); SHAOHUI WU (CENTERVILLE, Georgia); MICHAEL TOEWS (TIFTON, Georgia); LOUELA CASTRILLO (ITHACA, New York) |
ABSTRACT | The invention relates to biocontrol compositions comprising an entomopathogenic fungus, kits comprising such an entomopathogenic fungus, and methods of using such a fungus and compositions to reduce or kill the population of agricultural, vegetable, or horticultural crop insect pests. |
FILED | Thursday, April 16, 2020 |
APPL NO | 16/850516 |
CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/02 (20130101) A01N 63/30 (20200101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322805 | Detweiler et al. |
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FUNDED BY |
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APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
ASSIGNEE(S) | |
INVENTOR(S) | Carrick Detweiler (Lincoln, Nebraska); Sebastian Elbaum (Lincoln, Nebraska); James Higgins (Lincoln, Nebraska); Christian Laney (Papillion, Nebraska); Craig Allen (Crete, Nebraska); Dirac Twidwell (Lincoln, Nebraska); Evan Michael Beachly (Lincoln, Nebraska) |
ABSTRACT | An unmanned aerial vehicle (UAV) can be configured for fire suppression and ignition. In some examples, the UAV includes an aerial propulsion system, an ignition system, and a control system. The ignition system includes a container of delayed-ignition balls and a dropper configured, by virtue of one or more motors, to actuate and drop the delayed-ignition balls. The control system is configured to cause the UAV to fly to a site of a prescribed burn and, while flying over the site of the prescribed burn, actuate one or more of the delayed-ignition balls. After actuating the one or more delayed-ignition balls, the UAV drops the actuated one or more delayed-ignition balls from the UAV onto the site of the prescribed burn. |
FILED | Monday, June 28, 2021 |
APPL NO | 17/360027 |
CURRENT CPC | Fire-fighting A62C 3/025 (20130101) Original (OR) Class Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/12 (20130101) B64C 2201/024 (20130101) B64C 2201/027 (20130101) B64C 2201/123 (20130101) B64C 2201/141 (20130101) B64C 2201/146 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 1/02 (20130101) B64D 1/16 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0016 (20130101) G05D 1/0038 (20130101) G05D 1/0055 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324016 | YU et al. |
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FUNDED BY |
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APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
ASSIGNEE(S) | |
INVENTOR(S) | QINGZHONG YU (ATHENS, Georgia); STEPHEN J. SPATZ (BOGART, Georgia); JOHN R. DUNN (EAST LANSING, Georgia) |
ABSTRACT | Provided herein are immunogenic compositions containing recombinant viruses capable of inducing protection in poultry against both Marek's disease virus (MDV) and Newcastle disease virus (NDV). Such viruses incorporate nucleic acids for expressing at least one MDV antigen, such as glycoprotein B, and antigenic portions thereof, in a recombinant NDV genome. |
FILED | Wednesday, April 15, 2020 |
APPL NO | 16/848880 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/055 (20130101) C07K 14/125 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
US 20210322004 | Khanicheh et al. |
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FUNDED BY |
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APPLICANT(S) | EnVision Endoscopy, Inc. (Somerville, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Azadeh Khanicheh (Somerville, Massachusetts); Isaac Ostrovsky (Wellesley, Massachusetts) |
ABSTRACT | Provided herein is an endoscopic suturing system configured for attachment to, and use with, an endoscope. |
FILED | Tuesday, June 22, 2021 |
APPL NO | 17/354649 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/0469 (20130101) Original (OR) Class A61B 17/0491 (20130101) A61B 2017/047 (20130101) A61B 2017/00473 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322689 | Hoekman et al. |
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FUNDED BY |
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APPLICANT(S) | Impel Neuropharma, Inc. (Seattle, Washington) |
ASSIGNEE(S) | |
INVENTOR(S) | John D. Hoekman (Seattle, Washington); Michael Hite (Normandy Park, Washington); Alan Brunelle (Woodinville, Washington); Joel Relethford (Everett, Washington) |
ABSTRACT | A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle. |
FILED | Monday, February 01, 2021 |
APPL NO | 17/164371 |
CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 15/08 (20130101) Original (OR) Class A61M 15/0021 (20140204) A61M 16/127 (20140204) A61M 16/208 (20130101) A61M 2210/0612 (20130101) A61M 2210/0618 (20130101) A61M 2210/1067 (20130101) A61M 2210/1475 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 1/14 (20130101) B05B 7/08 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325405 | Padmanabhan et al. |
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FUNDED BY |
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APPLICANT(S) | RETHAM TECHNOLOGIES, LLC (Wauwatosa, Wisconsin) |
ASSIGNEE(S) | |
INVENTOR(S) | Anand Padmanabhan (Rochester, Minnesota); Curtis G. Jones (Wauwatosa, Wisconsin) |
ABSTRACT | Described is a method for identifying pathogenic platelet-activating antibodies in a subject's blood and particularly antibodies implicated in heparin-induced thrombocytopenia (HIT) which comprises the preparation of a platelet releasate from a normal subject's platelets, the combination of the platelet release with a normal subject's platelets, a test subject's blood sample, and analyzing the sample for platelet activation. |
FILED | Monday, April 19, 2021 |
APPL NO | 17/234182 |
CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0644 (20130101) C12N 2500/42 (20130101) C12N 2501/30 (20130101) C12N 2501/998 (20130101) C12N 2523/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 33/545 (20130101) G01N 33/6857 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327133 | Redden et al. |
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FUNDED BY |
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APPLICANT(S) | Blue River Technology Inc. (Sunnyvale, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Lee Kamp Redden (Palo Alto, California); Nicholas Apostoloff (San Jose, California) |
ABSTRACT | A technique for generating virtual models of plants in a field is described. Generally, this includes recording images of plants in-situ; generating point clouds from the images; generating skeleton segments from the point cloud; classifying a subset of skeleton segments as unique plant features using the images; and growing plant skeletons from skeleton segments classified as unique plant feature. The technique may be used to generate a virtual model of a single, real plant, a portion of a real plant field, and/or the entirety of the real plant field. The virtual model can be analyzed to determine or estimate a variety of individual plant or plant population parameters, which in turn can be used to identify potential treatments or thinning practices, or predict future values for yield, plant uniformity, or any other parameter can be determined from the projected results based on the virtual model. |
FILED | Friday, May 21, 2021 |
APPL NO | 17/327516 |
CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/33 (20170101) G06T 7/74 (20170101) G06T 7/194 (20170101) G06T 7/337 (20170101) G06T 7/344 (20170101) G06T 15/08 (20130101) G06T 17/05 (20130101) Original (OR) Class G06T 17/20 (20130101) G06T 2210/56 (20130101) G06T 2219/2008 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210328253 | Zhang et al. |
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FUNDED BY |
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APPLICANT(S) | Navitas Systems, LLC (Lisle, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Pu Zhang (Ann Arbor, Michigan); Michael Wixom (Ann Arbor, Michigan); Qingliu Wu (Ann Arbor, Michigan) |
ABSTRACT | Provided are electrode active materials with a porous structure and including a metal, that when loaded with sulfur serve as electrochemically superior cathode active materials. The metal structures are optionally used on their own, are coated with another material, or coats another porous structure such as a porous carbon structure that allows for excellent retention of both sulfur and polysulfides, are conductive themselves, and show long term stability and excellent cycle life. |
FILED | Monday, June 28, 2021 |
APPL NO | 17/360687 |
CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/13 (20130101) H01M 4/38 (20130101) H01M 4/134 (20130101) H01M 4/0402 (20130101) H01M 4/624 (20130101) H01M 4/625 (20130101) H01M 4/663 (20130101) H01M 4/808 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) Original (OR) Class H01M 2004/027 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
US 20210321955 | Samadani |
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FUNDED BY |
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APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York); THE U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTME (Washington, District of Columbia) |
ASSIGNEE(S) | NEW YORK UNIVERSITY (New York, New York); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
INVENTOR(S) | Uzma Samadani (New York, New York) |
ABSTRACT | A method for detecting, diagnosing or screening for concussion in a subject includes a) tracking eye movement of at least one eye of the subject, b) analyzing eye movement of at least one eye of the subject, c) calculating a statistical test for eye movement of at least one eye of the subject as compared to a normal or mean eye movement, and d) detecting, diagnosing or screening for an impairment based on the calculated statistical test. |
FILED | Wednesday, February 10, 2021 |
APPL NO | 17/173173 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/0041 (20130101) A61B 3/085 (20130101) A61B 3/113 (20130101) A61B 5/031 (20130101) A61B 5/4064 (20130101) A61B 5/7278 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322529 | Lubaroff et al. |
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FUNDED BY |
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APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa); THE UNITED STATES GOVERNMENT DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
ASSIGNEE(S) | |
INVENTOR(S) | David M. Lubaroff (Iowa City, Iowa); Delbert L. Harris (Ames, Iowa) |
ABSTRACT | A method of vaccinating a subject is provided, where a cancer protective response is produced. A first vaccine comprises an adenovirus vector comprising at least one nucleic acid molecule that produces a cancer protective response is administered, followed by one or more second vaccines comprising an alphavirus replicon particle comprising RNA comprising or produced from the nucleic acid molecule. In an embodiment the cancer is prostate cancer. |
FILED | Tuesday, June 29, 2021 |
APPL NO | 17/304953 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001193 (20180801) Original (OR) Class A61K 39/001194 (20180801) A61K 39/001195 (20180801) A61K 2039/545 (20130101) A61K 2039/884 (20180801) A61K 2039/5256 (20130101) A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10341 (20130101) C12N 2770/36123 (20130101) C12N 2770/36143 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323932 | Montano et al. |
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FUNDED BY |
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APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
ASSIGNEE(S) | |
INVENTOR(S) | Monica Montano (Shaker Heights, Ohio); Matthew C. Lawes (Shaker Heights, Ohio) |
ABSTRACT | Compounds for use in treating cancer include inhibitors of KDM5B and/or inducers of HEXIM1 and/or p21 are described herein. |
FILED | Monday, April 19, 2021 |
APPL NO | 17/234343 |
CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 241/44 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324004 | PAHAN |
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FUNDED BY |
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APPLICANT(S) | Rush University Medical Center (Chicago, Illinois) |
ASSIGNEE(S) | Rush University Medical Center (Chicago, Illinois) |
INVENTOR(S) | Kalipada PAHAN (Skokie, Illinois) |
ABSTRACT | Compositions for inhibiting the binding between ACE2 and SARS-CoV-2 spike S1 are disclosed. Methods of treating COVID-19 are disclosed. Methods of making an in vivo model of COVID-19 are also disclosed. |
FILED | Wednesday, December 23, 2020 |
APPL NO | 17/133035 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 38/00 (20130101) A61K 38/08 (20130101) A61K 38/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
US 20210324312 | Esch et al. |
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FUNDED BY |
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APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
ASSIGNEE(S) | |
INVENTOR(S) | Mandy Brigitte Esch (Gaithersburg, Maryland); Longyi Chen (Gaithersburg, Maryland) |
ABSTRACT | A body cube for culturing tissue that includes: an organ chip holder; and a body barrier chip and a first body organ chip disposed in the organ chip holder, the first body organ chip including a first cell culture chamber that receives cell culture medium and produces a first tissue in the first cell culture chamber, such that the organ chip holder receives cell culture medium and communicates the cell culture medium to the first cell culture chamber of the first body organ chip in response to rotation of the organ chip holder. |
FILED | Monday, April 19, 2021 |
APPL NO | 17/234298 |
CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 25/06 (20130101) C12M 29/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325421 | Shinder et al. |
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FUNDED BY |
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APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
ASSIGNEE(S) | |
INVENTOR(S) | Iosif Isaakovich Shinder (Gaithersburg, Maryland); Aaron Nathaniel Johnson (Gaithersburg, Maryland); Bernard James Filla (Nederland, Colorado) |
ABSTRACT | A non-nulling gas velocity measurement apparatus performs a non-nulling measurement of gas velocity parameters and includes: a non-nulling pitot probe; gas valves in fluid communication with a different entrant aperture of the non-nulling pitot probe via a different pressure channel; receives stagnant gas from the respective entrant aperture; receives a reference gas; receives a valve control signal; and produces a valve-selected gas based on the valve control signal, the valve-selected gas consisting essentially of the reference gas or the stagnant gas; and a plurality of differential pressure transducers, such that each differential pressure transducer: is separately and independently in fluid communication with a different gas valve, and that gas valve communicates the valve-selected gas to the differential pressure transducer; receives the valve-selected gas from the gas valve; and produces a differential pressure signal from comparison of the pressure of the valve-selected gas to a reference gas pressure. |
FILED | Thursday, April 15, 2021 |
APPL NO | 17/231468 |
CURRENT CPC | Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 5/16 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
US 20210321623 | White et al. |
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FUNDED BY |
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APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); U.S. Geological Survey (Ann Arbor, Michigan) |
ASSIGNEE(S) | |
INVENTOR(S) | James F. White (New Brunswick, New Jersey); Kurt P. Kowalski (Ann Arbor, Michigan); Kathryn L. Kingsley (Robbinsville, New Jersey); Matthew T. Elmore (East Brunswick, New Jersey) |
ABSTRACT | Endophytic bacteria, compositions comprising the same, and methods of use thereof are disclosed which suppress growth of aggressive, invasive weed species which grow in the same habitat of target plants of interest. |
FILED | Friday, August 09, 2019 |
APPL NO | 17/266489 |
CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/27 (20200101) Original (OR) Class A01N 63/32 (20200101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210322414 | Smith et al. |
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FUNDED BY |
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APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
ASSIGNEE(S) | |
INVENTOR(S) | Lois Smith (West Newton, Massachusetts); Jean-Sebastien Joyal (Boston, Massachusetts) |
ABSTRACT | The instant invention provides methods and compositions related to discovery of Free Fatty Acid Receptor 1 (FFA1) as a therapeutic target for treatment or prevention of diseases or disorders of neurons that are characterized by angiogenesis, or of vascular diseases of the eye, retinal degeneration and/or tumors more generally. Therapeutic and/or prophylactic uses and compositions of known FFA1 inhibitors, including small molecules and nucleic acid agents, are described. Methods for identification of novel FFA1 inhibitors are also provided. |
FILED | Friday, February 17, 2017 |
APPL NO | 15/999535 |
CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/513 (20130101) Original (OR) Class A61K 31/519 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) G01N 2800/50 (20130101) G01N 2800/164 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
Central Intelligence Agency (CIA)
US 20210328976 | Leavy et al. |
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FUNDED BY |
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APPLICANT(S) | Wickr Inc. (Pleasanton, California) |
ASSIGNEE(S) | |
INVENTOR(S) | Thomas Michael Leavy (River Edge, New Jersey); Christopher Howell (Pleasanton, California); Joël Alwen (Vienna, Austria) |
ABSTRACT | A method, system, and non-transitory computer readable medium are described for providing a sender a plurality of ephemeral keys such that a sender and receiver can exchange encrypted communications. Accordingly, a sender may retrieve information, such as a public key and a key identifier, for the first receiver from a local storage. The retrieved information may be used to generate a key-encrypting key that is used to generate a random communication encryption key. The random communication encryption key is used to encrypt a communication, while the key-encrypting key encrypts the random communication key. The encrypted communication and the encrypted random communication key are transmitted to the first receiver. |
FILED | Friday, July 02, 2021 |
APPL NO | 17/366215 |
CURRENT CPC | Electric Digital Data Processing G06F 21/602 (20130101) G06F 21/606 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/14 (20130101) H04L 9/0822 (20130101) H04L 9/0825 (20130101) H04L 9/0841 (20130101) H04L 9/0869 (20130101) H04L 9/0894 (20130101) H04L 63/062 (20130101) H04L 63/068 (20130101) H04L 63/0442 (20130101) Original (OR) Class H04L 2209/08 (20130101) H04L 2209/601 (20130101) H04L 2463/062 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
US 20210324794 | Lin et al. |
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FUNDED BY |
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APPLICANT(S) | General Electric Company (Schenectady, New York) |
ASSIGNEE(S) | |
INVENTOR(S) | Wendy Wenling Lin (Montgomery, Ohio); Shanmugam Murugappan (Mason, Ohio); Robert William Davidoff (Pittsburgh, Pennsylvania); Graham Frank Howarth (Middletown, Delaware); Andrew Michael Roach (Aberdeen, Maryland) |
ABSTRACT | An acoustic core has a plurality of cell walls formed of an additive-manufacturing material and a resonant space defined by the plurality of cell walls. At least some of the resonant cells have a multitude of sound-attenuating protuberances formed of the additive-manufacturing material of the cell walls protruding into the resonant space with a random or semi-random orientation and/or size. The sound-attenuating protuberances may be formed by orienting an additive-manufacturing tool with respect to a toolpath to form a contour of a workpart, in which the toolpath includes a plurality of overlapping toolpath passes configured so as to intentionally introduce an amount of additive-manufacturing material to the workpart that exceeds a domain occupied by the contour. As the amount of additive-manufacturing material intentionally introduced exceeds the domain occupied by the contour, a portion of the additive-manufacturing material may incidentally form the plurality of sound-attenuating protuberances. |
FILED | Friday, May 28, 2021 |
APPL NO | 17/333085 |
CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/10 (20210101) Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 15/008 (20130101) Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 1/001 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/10 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7504 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 80/00 (20141201) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/045 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
US 20210321623 | White et al. |
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FUNDED BY |
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APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); U.S. Geological Survey (Ann Arbor, Michigan) |
ASSIGNEE(S) | |
INVENTOR(S) | James F. White (New Brunswick, New Jersey); Kurt P. Kowalski (Ann Arbor, Michigan); Kathryn L. Kingsley (Robbinsville, New Jersey); Matthew T. Elmore (East Brunswick, New Jersey) |
ABSTRACT | Endophytic bacteria, compositions comprising the same, and methods of use thereof are disclosed which suppress growth of aggressive, invasive weed species which grow in the same habitat of target plants of interest. |
FILED | Friday, August 09, 2019 |
APPL NO | 17/266489 |
CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/27 (20200101) Original (OR) Class A01N 63/32 (20200101) |
VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
US 20210322998 | O'Connor et al. |
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FUNDED BY |
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APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
ASSIGNEE(S) | |
INVENTOR(S) | Megan O'Connor (Guilford, Connecticut); Desiree Plata (Guilford, Connecticut) |
ABSTRACT | The invention provides a novel filtration apparatus for the selective separation of metals from a mixture thereof. The invention also provides a method for the separation and isolation of metals from a sample using electrochemical precipitation. |
FILED | Tuesday, April 27, 2021 |
APPL NO | 17/241520 |
CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/205 (20130101) B01J 20/28026 (20130101) Separating Solid Materials Using Liquids or Using Pneumatic Tables or Jigs B03B 5/00 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/172 (20170801) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) C02F 1/283 (20130101) C02F 1/463 (20130101) C02F 2305/08 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
US 20210325286 | KING et al. |
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FUNDED BY |
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APPLICANT(S) | THE BOEING COMPANY (Chicago, Illinois) |
ASSIGNEE(S) | |
INVENTOR(S) | Garnel KING (Madison, Alabama); Dennis L. COAD (Madison, Alabama); Jennifer L. CHEVALLIER (Huntsville, Alabama) |
ABSTRACT | The present disclosure provides an apparatus and method of use thereof for compressive creep testing of materials in the presence of fluids. The apparatus includes a cantilever arm connected on a first end to a cantilever pivot and including a weight holder on a second end; a first platen connected to the cantilever arm via a swivel located between the first end and the second end; a reservoir; and a second platen disposed within the reservoir and positioned to secure a sample between the first platen and the second platen when a force is applied via the weight holder and the first platen to a sample. Electrical properties of the material can be monitored and measured during the compression creep testing. |
FILED | Tuesday, April 21, 2020 |
APPL NO | 16/854537 |
CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/04 (20130101) G01N 3/14 (20130101) Original (OR) Class G01N 2203/0071 (20130101) G01N 2203/0242 (20130101) G01N 2203/0617 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
US 20210325952 | Ardanaz et al. |
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FUNDED BY |
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APPLICANT(S) | INTEL CORPORATION (Santa Clara, California) |
ASSIGNEE(S) | INTEL CORPORATION (SANTA CLARA, California) |
INVENTOR(S) | Federico Ardanaz (Hillsboro, Oregon); Jonathan M. Eastep (Portland, Oregon); Richard J. Greco (West Linn, Oregon); Ramkumar Nagappan (Chandler, Arizona); Alan B. Kyker (Winters, California) |
ABSTRACT | Apparatus, systems, and methods provide an interface between a plurality of hardware resources of a node and a power manager. The interface is configured to define one or more resource groups to expose to the power manager for power measurement and control, assign the plurality of hardware resources to the one or more resource groups, and provide a power allowance to each resource group. |
FILED | Thursday, June 24, 2021 |
APPL NO | 17/357479 |
CURRENT CPC | Electric Digital Data Processing G06F 1/325 (20130101) Original (OR) Class G06F 1/3287 (20130101) G06F 1/3293 (20130101) Climate Change Mitigation Technologies in Information and Communication Technologies [ICT] i.e Information and Communication Technologies Aiming at the Reduction of Their Own Energy Use Y02D 10/00 (20180101) |
VIEW PATENT | @ USPTO: Full Text PDF |
Nuclear Regulatory Commission (NRC)
US 20210327599 | Hayes et al. |
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FUNDED BY |
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APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
ASSIGNEE(S) | |
INVENTOR(S) | Robert Bruce Hayes (Clayton, North Carolina); Michael Jeffrey DeVanzo (Coatesville, Pennsylvania) |
ABSTRACT | Conformal coatings provide environmental protection for sensitive military electronics. Preliminary MCNP™ modeling of metal oxide impregnated acrylic conformal coatings indicates an effective shield for gammas below 10 keV and a reduction in neutron displacement damage to Si-based electronics across the Watt spectrum. This work provides data which can allow an optimal overall shielding worth per total weight to eventually be evaluated. |
FILED | Friday, April 16, 2021 |
APPL NO | 17/233312 |
CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/10 (20200101) B33Y 80/00 (20141201) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 167/07 (20130101) Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 1/08 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 9/0081 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
US 20210321866 | Schuster |
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FUNDED BY |
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APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
ASSIGNEE(S) | |
INVENTOR(S) | Paul R. Schuster (Baltimore, Maryland) |
ABSTRACT | An example imaging apparatus that can operate at shortwave infrared (SWIR) wavelengths are provided. An example imaging apparatus may include a flexible elongate member having a distal end and proximal end. The flexible elongate member may include a shortwave infrared (SWIR) imaging sensor disposed at the distal end and a lens optically coupled to the SWIR imaging sensor and disposed at the distal end of the flexible elongate member, the lens configured to focus light energy at the SWIR wavelength onto the SWIR imaging sensor. The member may also include an illumination source configured to provide light energy at the SWIR wavelength at the distal end of the flexible elongate member for output to illuminate an object. |
FILED | Tuesday, May 11, 2021 |
APPL NO | 17/317495 |
CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/05 (20130101) Original (OR) Class A61B 1/00009 (20130101) A61B 1/00043 (20130101) A61B 1/0052 (20130101) A61B 1/0057 (20130101) A61B 1/063 (20130101) A61B 1/00188 (20130101) A61B 1/0638 (20130101) A61B 1/0646 (20130101) A61B 1/0669 (20130101) A61B 1/0676 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210323128 | Alabi |
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FUNDED BY |
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APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
ASSIGNEE(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
INVENTOR(S) | Oluwaseun B. Alabi (South Windsor, Connecticut) |
ABSTRACT | A tool system to install an interference fit component within a bore of a component, includes a guide bushing that at least partially fits within a bore of a component. A drive screw is of a length to extend through the guide bushing and the bore. A threaded insert is receivable at least partially within the bore, the threaded insert receivable at least partially within the interference fit component. |
FILED | Friday, June 25, 2021 |
APPL NO | 17/358636 |
CURRENT CPC | Tools or Bench Devices Not Otherwise Provided For, for Fastening, Connecting, Disengaging or Holding B25B 27/023 (20130101) Original (OR) Class B25B 27/026 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/60 (20130101) F05D 2230/64 (20130101) F05D 2260/37 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324749 | Virkler |
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FUNDED BY |
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APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
ASSIGNEE(S) | |
INVENTOR(S) | Scott D. Virkler (Ellington, Connecticut) |
ABSTRACT | A rotor assembly is provided for a piece of rotational equipment. This rotor assembly includes a rotor disk, a rotor blade and a seal element. The rotor disk is configured to rotate about a rotational axis. The rotor disk extends axially along the rotational axis to a rotor disk end face. The rotor blade includes an attachment. The attachment attaches the rotor blade to the rotor disk. The seal element is configured to seal a gap between the rotor disk and the attachment. The seal element has a longitudinal centerline that extends along an interface between the rotor disk and the attachment at the rotor disk end face. |
FILED | Friday, April 17, 2020 |
APPL NO | 16/851832 |
CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/3015 (20130101) F01D 5/3092 (20130101) Original (OR) Class F01D 11/006 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2240/57 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210324888 | Sabo |
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FUNDED BY |
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APPLICANT(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (Falls Church, Virginia) |
ASSIGNEE(S) | |
INVENTOR(S) | Scott G. Sabo (Long Beach, California) |
ABSTRACT | A release mechanism for releasably securing a releasable structure to a stationary structure, where the mechanism employs release balls that can re-secure the releasable structure to the stationary structure. The release mechanism includes a base portion having three rails extending radially outward from a center of the base portion, and a rotatable portion rotatably mounted to the base portion, where the rotatable portion has a cam indentation. The release balls are positioned between the base portion and the rotatable portion so that one of the release balls is ridable on each of the rails and all of the release balls are positioned within the cam indentation. The cam indentation is configured so that as the rotatable portion is rotated relative to the base portion the cam indentation causes and allows the release balls to move along the rails in unison with each other to hold and release the releasable structure. |
FILED | Monday, April 20, 2020 |
APPL NO | 16/852852 |
CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/222 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 5/06 (20130101) Original (OR) Class |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210325270 | Williams et al. |
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FUNDED BY |
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APPLICANT(S) | Jeremiah Williams (Dayton, Ohio); Hengky Chandrahalim (Beavercreek, Ohio) |
ASSIGNEE(S) | |
INVENTOR(S) | Jeremiah Williams (Dayton, Ohio); Hengky Chandrahalim (Beavercreek, Ohio) |
ABSTRACT | A passive microscopic Fabry-Pérot Interferometer (FPI) pressure sensor includes an optical fiber and a three-dimensional microscopic optical enclosure. The three-dimensional microscopic optical enclosure includes tubular side walls having lateral pleated corrugations and attached to a cleaved tip of the optical fiber to receive a light signal. An optically reflecting end wall is distally engaged to the tubular side walls to enclose a trapped quantity of gas that longitudinally positions the optically reflecting end wall in relation to ambient air pressure, changing a distance traveled by a light signal reflected back through the optical fiber. |
FILED | Wednesday, April 14, 2021 |
APPL NO | 17/229986 |
CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 11/025 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 6/29359 (20130101) G02B 6/29395 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
US 20210327624 | STRAND |
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FUNDED BY |
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APPLICANT(S) | JOEL D. STRAND (ELLICOTT CITY, Maryland) |
ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
INVENTOR(S) | JOEL D. STRAND (ELLICOTT CITY, Maryland) |
ABSTRACT | One example includes a superconducting current control system. The system includes an inductive coupler comprising a load inductor and a control inductor. The inductive coupler can be configured to inductively provide a control current from the control inductor to a superconducting circuit device based on a load current being provided through the load inductor. The system also includes a current control element comprising a superconducting quantum interference device (SQUID) array comprising a plurality of SQUIDs. The current control element can be coupled to the inductive coupler to control an amplitude of the load current through the load inductor, and thus to control an amplitude of the control current to the superconducting circuit device. |
FILED | Wednesday, April 15, 2020 |
APPL NO | 16/849595 |
CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/008 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/18 (20130101) H01L 39/025 (20130101) H01L 39/223 (20130101) |
VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, October 21, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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