FedInvent™ Patent Applications
Application Details for Thursday, October 28, 2021
This page was updated on Thursday, October 28, 2021 at 04:44 PM GMT
Department of Health and Human Services (HHS)
| US 20210329919 | Movassaghi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Movassaghi (Lincoln, Massachusetts); Matthew M. Pompeo (Cambridge, Massachusetts); Jaime Cheah (Medford, Massachusetts) |
| ABSTRACT | Described herein are compounds of Formula (I): and salts, tautomers, and stereoisomers thereof. Methods of making the compounds, salts, tautomers, and stereoisomers are also described. Further described herein are composition, kits, methods, and uses involving the compounds, salts, tautomers, and stereoisomers. The methods include methods of treating and preventing diseases (e.g., cancers) in subjects (e.g., humans). |
| FILED | Thursday, April 30, 2020 |
| APPL NO | 16/863015 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/90 (20130101) Original (OR) Class Heterocyclic Compounds C07D 471/22 (20130101) C07D 519/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330240 | SCHALK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Health Research, Inc. (Menands, New York); Albany Medical College (Albany, New York) |
| ASSIGNEE(S) | Health Research, Inc. (Menands, New York); Albany Medical College (Albany, New York) |
| INVENTOR(S) | Gerwin SCHALK (Glenmont, New York); Anthony L. RITACCIO (Voorheesville, New York); Adriana DE PESTERS (Coppet, Switzerland); AmiLyn TAPLIN (Albany, New York) |
| ABSTRACT | Provided is a method for mapping a neural area involved in speech processing, including applying a plurality of recording electrodes to a surface of a cortex of a human subject, presenting a plurality of auditory stimuli to the subject wherein some of the plurality of stimuli are speech sounds and others of the plurality of auditory stimuli are non-speech sounds, recording brain activity during the presenting of the plurality of auditory stimuli, and identifying one or more brain areas wherein activity changes more after presentation of speech sounds than it does after presentation of non-speech sounds, wherein the human subject does not speak during the presenting and the recording. Also provided is a method for mapping a neural area involved in speech production wherein the human subject does not speak during presenting speech stimuli and recording neural activity. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 17/365032 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/38 (20210101) Original (OR) Class A61B 5/4064 (20130101) A61B 5/4094 (20130101) A61B 2505/05 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/32 (20130101) A61N 1/0531 (20130101) A61N 1/36082 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330242 | Huggins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jane E. Huggins (Fenton, Michigan); Seth Warschausky (Ann Arbor, Michigan); Ramses Eduardo Alcaide (Ann Arbor, Michigan) |
| ABSTRACT | Methods, systems, apparatus, and non-transitory computer readable media are disclosed utilizing brain-computer interfaces (BCIs). Various embodiments are disclosed to allow a user to directly select multiple-choice answers, to provide motorized wheelchair controls, and to allow a user to play a game via the BCI. When used in a cognitive assessment test, embodiments include the administration of unmodified standardized tests with results in the same or a similar format as those taken without a BCI. Various embodiments are disclosed to improve the accuracy of BCI test administration using a three-step process for each test question, which includes determining whether the user intends to select an answer, monitoring user brain activity to determine a selected answer, and verifying the selected answer. In addition, the selected answer may be verified by monitoring user brain activity in accordance with a hold-release process to determine whether a user intends to initiate a state change. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/368207 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/316 (20210101) A61B 5/374 (20210101) A61B 5/378 (20210101) A61B 5/742 (20130101) A61B 5/4088 (20130101) Original (OR) Class A61B 5/7221 (20130101) A61B 5/7264 (20130101) A61B 5/7267 (20130101) A61B 5/7282 (20130101) A61B 5/7435 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) A61F 4/00 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330328 | Dreilinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NeuraMedica Inc. (Oregon City, Oregon) |
| ASSIGNEE(S) | NeuraMedica Inc. (Oregon City, Oregon) |
| INVENTOR(S) | Rachel Dreilinger (Beavercreek, Oregon); Neil Roundy (Eugene, Oregon); Mariah Knight (Cornelius, Oregon); Sandra Baker (Tigard, Oregon) |
| ABSTRACT | A medical device forming method, an applier for manipulating clips, and a cartridge for holding clips are disclosed herein. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 16/858546 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/083 (20130101) Original (OR) Class A61B 17/1222 (20130101) A61B 2017/0488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330585 | CATTERUCCIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Flaminia CATTERUCCIA (Cambridge, Massachusetts); Douglas Graeme PATON (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are methods and compositions for reducing transmission of Plasmodium to a female mosquito. Aspects of the invention relate to contacting to a mosquito with a Plasmodium transmission blocking compound. Another aspect of the invention relates to a surface coated with a Plasmodium transmission blocking compound. |
| FILED | Tuesday, September 03, 2019 |
| APPL NO | 17/271384 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 35/06 (20130101) A01N 37/42 (20130101) A01N 43/60 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0017 (20130101) Original (OR) Class A61K 31/122 (20130101) A61K 31/222 (20130101) A61K 31/357 (20130101) A61K 31/495 (20130101) A61K 31/4192 (20130101) A61K 47/12 (20130101) A61K 47/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330588 | Kohane et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Daniel S. Kohane (Newton, Massachusetts); Tianjiao Ji (Allson, Massachusetts); Christopher B. Weldon (Boston, Massachusetts) |
| ABSTRACT | Compositions and methods of use related to formulations comprising anesthetics are generally described. Some embodiments are directed to compositions comprising a plurality of micelles and/or particles, and an anesthetic contained internally. These can be used to control and/or prolong the duration of IVRA while reducing the risk of systemic toxicity commonly due to administering anesthetics. The control and/or prolonged duration of IVRA may be due, at least in part, to the attachment of the sufficiently small micelles and/or particles to a biointerface (e.g., blood vessel surface) where the composition has been administered. Conventional IVRA methods commonly do not utilize potent and long-acting anesthetics (e.g., bupivacaine) due to the risks of cardiac toxicity. The compositions and methods described herein, however, provide a pathway for increased safety and efficiency of the use of such anesthetics, in certain embodiments. Resultantly, the performance (e.g., anesthetic distribution) of the micelles and/or particles internally containing an anesthetic may be comparatively better than the performance of free anesthetic, e.g., with respect to nerve blood and systematic drug distribution. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 17/284171 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/1075 (20130101) A61K 9/1271 (20130101) Original (OR) Class A61K 31/167 (20130101) A61K 31/445 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330598 | MAJUMDAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Mississippi (University, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Soumyajit MAJUMDAR (Oxford, Mississippi); Akash PATIL (Malvern, Pennsylvania); Prit LAKHANI (North Brunswick Town, New Jersey) |
| ABSTRACT | Compositions of nanolipid carrier molecules comprising PEG molecules and solid and liquid lipids wherein the PEG has a molecular weight of between about 1000 and 5000 are described. Methods of administering nanolipid carrier molecules are also described. Also described is a method for treating fungal ocular infections by topical ocular administration of nanolipid carrier molecules comprising PEG molecules and solid and liquid lipids wherein the PEG has a molecular weight of between about 1000 and 5000. |
| FILED | Monday, August 05, 2019 |
| APPL NO | 17/265644 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/10 (20130101) A61K 9/5123 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 9/5161 (20130101) A61K 31/7048 (20130101) A61K 47/186 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330599 | BENOIT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danielle BENOIT (Rochester, New York); Hyun KOO (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods to treat and/or prevent biofilms and biofilm related diseases. The invention comprises a nanoparticle carrier (NPC) and at least one therapeutic agent therein. The NPC binds within biofilm and to surfaces at risk for biofilm formation and accumulation while providing local, sustained, enhanced and controlled delivery of the therapeutic agent, when triggered for release. In one embodiment, the NPC comprises pH-responsive elements that allows for specific delivery of the therapeutic agent when the local environment dictates that the agent should be delivered precisely when it is most needed. |
| FILED | Tuesday, August 01, 2017 |
| APPL NO | 16/322636 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/5026 (20130101) A61K 9/5138 (20130101) Original (OR) Class A61K 31/045 (20130101) A61K 31/155 (20130101) A61K 31/352 (20130101) A61K 31/353 (20130101) A61K 31/505 (20130101) A61K 33/16 (20130101) A61K 33/18 (20130101) A61K 33/22 (20130101) A61K 38/47 (20130101) A61K 38/443 (20130101) A61K 45/06 (20130101) A61K 47/6925 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/02 (20180101) A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330603 | Mellies et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REED INSTITUTE (Portland, Oregon); THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay Mellies (Portland, Oregon); Vanessa Sperandio (Austin, Texas) |
| ABSTRACT | Methods of treating a subject having a gram negative bacterial infection by administering a cannabinoid such as 2-AG,CBD, the MgI inhibitor JZL184, or arachidonic acid to the subject are provided. Methods of prophylactically treating a subject at risk of developing a gram negative bacterial infection and for reducing the bacterial virulence in an infected subject are also provided. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184350 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) Original (OR) Class A61K 31/232 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330604 | Brosnan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Robert J. Brosnan (Davis, California) |
| ABSTRACT | A method of inducing anesthesia in a subject is provided. In some embodiments, the method provides administering to the subject via the respiratory system or via injection, an effective amount of a compound or a mixture of compounds selected from the group consisting of methyl-ethyl ethers, methyl-isopropyl ethers, and methyl-propyl ethers. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 17/032371 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 9/0019 (20130101) A61K 9/0073 (20130101) A61K 31/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330611 | Akassoglou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Katerina Akassoglou (San Francisco, California); Anke Meyer-Franke (Menlo Park, California); Alex Pico (San Francisco, California); Kean-Hooi Ang (San Francisco, California); Michelle Rose Arkin (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katerina Akassoglou (San Francisco, California); Anke Meyer-Franke (Menlo Park, California); Alex Pico (San Francisco, California); Kean-Hooi Ang (San Francisco, California); Michelle Rose Arkin (San Francisco, California) |
| ABSTRACT | Provided herein are compositions and methods to treat or prevent neurodegeneration in a mammal, inhibit microglial activation in the CNS of a mammal, promote survival of CNS neurons in a mammal, prevent or reduce the rate of demyelination and/or neuronal injury in a mammal, promote remyelination in a mammal and/or treat or prevent or decrease oxidative stress in a mammal. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229394 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Original (OR) Class A61K 31/165 (20130101) A61K 31/365 (20130101) A61K 31/475 (20130101) A61K 31/5415 (20130101) A61K 31/7024 (20130101) A61K 31/7048 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330678 | Agarwal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children`s Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suneet Agarwal (Lexington, Massachusetts); Neha Nagpal (Boston, Massachusetts) |
| ABSTRACT | The disclosure relates to compounds that are, e.g., PAP Associated Domain Containing 5 (PAPD5) inhibitors and methods of use thereof. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 17/273937 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/553 (20130101) Original (OR) Class A61K 31/4025 (20130101) A61K 31/4375 (20130101) A61K 31/4745 (20130101) A61K 31/5025 (20130101) A61K 31/5365 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0636 (20130101) C12N 5/0646 (20130101) C12N 5/0696 (20130101) C12N 2501/999 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330682 | SINHA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Sidhartha Ranjit SINHA (Stanford, California); Jayakumar RAJADAS (Stanford, California); Aida HABTEZION (Stanford, California); Ravinder D. PAMNANI (Stanford, California) |
| ABSTRACT | Enema compositions containing corticosteroids or salicylic acid derivatives are disclosed. The compositions are liquid at room temperature but turn to gels at body temperature. They are useful for treating inflammatory bowel disease. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332506 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0031 (20130101) A61K 9/107 (20130101) A61K 9/1272 (20130101) A61K 31/58 (20130101) Original (OR) Class A61K 31/60 (20130101) A61K 31/573 (20130101) A61K 31/606 (20130101) A61K 31/655 (20130101) A61K 47/24 (20130101) A61K 47/30 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Compositions of Macromolecular Compounds C08L 71/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330693 | Nguyen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wayne State University (Detroit, Michigan); Technion, Israel Institute of Technology (Haifa, Israel); University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | Wayne State University (Detroit, Michigan); Technion, Israel Institute of Technology (Haifa, Israel); University of Iowa Research Foundation (Iowa City, Iowa) |
| INVENTOR(S) | Hien M. Nguyen (Bloomfield Hills, Michigan); Ravi Sankar Loka (Detroit, Michigan); Eric Sletten (Royal Oak, Michigan); Israel Vlodavsky (Haifa, Israel) |
| ABSTRACT | Anti-heparanase compounds for the treatment of cancer are described. The anti-heparanase compounds are high affinity, synthetic glycopolymers that result in minimal anticoagulant activity. Stereoselective fluorinated forms of these compounds are also provided. |
| FILED | Thursday, December 05, 2019 |
| APPL NO | 17/311088 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330702 | Boss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Regents of the University of Colorado (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerry R. Boss (La Jolla, California); Adriano Chan (La Jolla, California); Matthew Brenner (Irvine, California); Sari Brenner Mahon (Irvine, California); Vikhyat Bebarta (Denver, Colorado) |
| ABSTRACT | Provided is a method, and pharmaceutical composition, to treat or prevent cyanide poisoning and/or methylmercaptan poisoning comprising administering to a subject in need an effective amount of tetrathionate by intramuscular injection or by intranasal administration. Also provided is a method for detecting the presence of tetrathionate in a sample by reacting it with cyanide and measuring the resulting thiocyanate with ferric nitrate. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/271284 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0043 (20130101) A61K 33/04 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/52 (20130101) G01N 2800/709 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330756 | Twiss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Jeffery L. Twiss (Columbia, South Carolina); Amar N. Kar (Lexington, South Carolina) |
| ABSTRACT | Deacetylation of rat Miro1 on Lysine 105 attenuates axon growth on non-permissive substrates by making mitochondria more sensitive to Ca levels, depolarizing mitochondrial membranes and blocking mitochondrial transport; the current disclosure provides an antibody that specifically recognizes the lysine 105 acetylated and not the deacetylated Miro1 protein. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188139 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 38/46 (20130101) Original (OR) Class Peptides C07K 16/40 (20130101) Enzymes C12Y 306/05 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330768 | Xue et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Chaoyang Xue (Newark, New Jersey); Amariliz Rivera (Newark, New Jersey) |
| ABSTRACT | This invention describes vaccine compositions and their methods of use utilizing inactivated fbp1Δ deletion mutant fungal cells. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224888 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0002 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/521 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330769 | DAVILA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| INVENTOR(S) | Eduardo DAVILA (Cockeyville, Maryland); Koji TAMADA (Ube City, Yamaguchi, Japan) |
| ABSTRACT | The present invention provides a universal, yet adaptable, anti-tag chimeric antigen receptor (AT-CAR) system which provides T cells with the ability and specificity to recognize and kill target cells, such as tumor cells, that have been marked by tagged antibodies. As an example, αFITC-CAR-expressing T cells have been developed that specifically recognize various human cancer cells when those cells are bound by cancer-reactive FITC-labeled antibodies. The activation of αFITC-CAR-expressing T cells is shown to induce efficient target lysis, T cell proliferation, and cytokine/chemokine production. The system can be used to treating subjects having cancer. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228001 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/39558 (20130101) A61K 47/555 (20170801) A61K 47/6855 (20170801) A61K 47/6859 (20170801) A61K 47/6863 (20170801) A61K 47/6897 (20170801) A61K 2039/572 (20130101) A61K 2039/585 (20130101) A61K 2039/5156 (20130101) Peptides C07K 16/44 (20130101) C07K 16/2863 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2501/515 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330773 | Lyerly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Herbert K. Lyerly (Durham, North Carolina); Michael A. Morse (Durham, North Carolina); Takuya Osada (Durham, North Carolina); Timothy M. Clay (Waterloo, Belgium); Zachary C. Hartman (Durham, North Carolina) |
| ABSTRACT | Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent, such as a checkpoint inhibitor and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding a HER3 polypeptide. Methods of using the vaccine including the polynucleotide encoding the HER3 polypeptide to treat a cancer or precancer are also provided. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/328953 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 39/001106 (20180801) Original (OR) Class A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/53 (20130101) A61K 2039/505 (20130101) A61K 2039/507 (20130101) A61K 2039/585 (20130101) A61K 2039/5256 (20130101) Peptides C07K 16/32 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/77 (20130101) C07K 2317/734 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330782 | Collins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Peter L. Collins (Silver Spring, Maryland); Cindy L. Luongo (Bethesda, Maryland); Ursula J. Buchholz (Silver Spring, Maryland); Brian R. Murphy (Bethesda, Maryland) |
| ABSTRACT | Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224819 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/155 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330785 | Mason et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hugh Mason (Phoenix, Arizona); Andrew Diamos (Tempe, Arizona); Mary Pardhe (Phoenix, Arizona); Brandon Favre (Los Gatos, California) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Hugh Mason (Phoenix, Arizona); Andrew Diamos (Tempe, Arizona); Mary Pardhe (Phoenix, Arizona); Brandon Favre (Los Gatos, California) |
| ABSTRACT | The disclosure relates to vaccination compositions, for example, against human papillomavirus, Zika virus, and flu virus. The disclosure also relates to vectors for producing the virus-like particles and immune complex platforms of the vaccination compositions. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/367296 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) A61K 39/292 (20130101) Original (OR) Class A61K 2039/70 (20130101) A61K 2039/505 (20130101) A61K 2039/575 (20130101) A61K 2039/5258 (20130101) A61K 2039/6056 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/20023 (20130101) C12N 2710/20034 (20130101) C12N 2710/20071 (20130101) C12N 2730/10123 (20130101) C12N 2730/10134 (20130101) C12N 2730/10171 (20130101) C12N 2760/16123 (20130101) C12N 2760/16134 (20130101) C12N 2760/16171 (20130101) C12N 2770/24134 (20130101) C12N 2770/24171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330800 | MOYNIHAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelly Dare MOYNIHAN (Allston, Massachusetts); Rebecca Lynn HOLDEN (Cambridge, Massachusetts); Darrell J. IRVINE (Arlington, Massachusetts); Bradley Lether PENTELUTE (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides a conjugate comprising an albumin binding peptide and a cargo, compositions for directing cargos to the lymphatic system, and vaccines. The methods of the invention can be used to increase an immune response, or to treat cancer or an infectious disease. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/371367 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/0011 (20130101) A61K 39/001192 (20180801) A61K 47/646 (20170801) Original (OR) Class A61K 2039/876 (20180801) A61K 2039/6031 (20130101) A61K 2039/6093 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) A61P 35/00 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/76 (20130101) C07K 14/4748 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330803 | BAUM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENERON PHARMACEUTICALS, INC. (Tarrytown, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alina BAUM (Pleasantville, New York); Thomas NITTOLI (Pearl River, New York) |
| ABSTRACT | Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with influenza, including VX-787 and derivatives thereof, baloxavir and derivatives thereof, and baloxavir marboxil and derivatives thereof, and protein (e.g., antibody) drug conjugates thereof. |
| FILED | Saturday, January 23, 2021 |
| APPL NO | 17/156525 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/5383 (20130101) A61K 47/6803 (20170801) A61K 47/6841 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330804 | HERRMANN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andreas HERRMANN (La Jolla, California); Hua YU (Glendora, California); Piotr Marek SWIDERSKI (San Dimas, California); John Ernest SHIVELY (Arcadia, California); Lin LI (Monrovia, California) |
| ABSTRACT | Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184237 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/44 (20130101) A61K 47/549 (20170801) A61K 47/6807 (20170801) A61K 47/6843 (20170801) Original (OR) Class A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) C07K 16/40 (20130101) C07K 16/084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330805 | OUERFELLI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ouathek OUERFELLI (New York, New York); Guangbin YANG (New York, New York); Sarah M. CHEAL (New York, New York); Steve LARSON (New York, New York) |
| ABSTRACT | The present disclosure provides compositions and methods for the treatment of cancer. Specifically, the compositions of the present technology include novel clearing agents that may be used in pretargeted radioimmunotherapy. |
| FILED | Wednesday, July 10, 2019 |
| APPL NO | 17/259663 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6893 (20170801) Original (OR) Class A61K 51/0482 (20130101) A61K 51/1045 (20130101) A61K 51/1048 (20130101) A61K 51/1054 (20130101) A61K 51/1063 (20130101) A61K 51/1066 (20130101) A61K 51/1072 (20130101) A61K 51/1093 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330808 | Sun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingjing Sun (Pittsburgh, Pennsylvania); Song Li (Mars, Pennsylvania) |
| ABSTRACT | A polymer includes a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one group including a plurality of hydroxyl groups, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one hydrophilic polymer. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/284562 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 31/12 (20130101) A61K 31/138 (20130101) A61K 31/337 (20130101) A61K 31/366 (20130101) A61K 31/404 (20130101) A61K 31/405 (20130101) A61K 31/436 (20130101) A61K 31/506 (20130101) A61K 31/551 (20130101) A61K 31/7068 (20130101) A61K 38/13 (20130101) A61K 47/54 (20170801) A61K 47/58 (20170801) A61K 47/60 (20170801) A61K 47/542 (20170801) A61K 47/6907 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210331160 | Cooper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David E. Cooper (Palo Alto, California); Rowena Bacher (Scotts Valley, California); Estevan Mendoza (Mountain View, California); Robert Balog (Sunnyvale, California); Kathryn Todd (Menlo Park, California); Kirk A. Bradley (Menlo Park, California) |
| ABSTRACT | Provided herein is an analyzing system including components and methods thereof. The analyzing system includes, in some embodiments, a test cartridge and an analyzer. The test cartridge can include a port for a biological sample; one or more lateral flow assay strips with one or more target capture zones for binding one or more targets of the biological sample; and a memory device including a development time for the test cartridge. The analyzer can include an opening for the cartridge; a reader/writer device for writing an initial time stamp for the biological sample to the memory device and reading it back; a processor configured to execute an algorithm and logic to ensure an elapsed time from the initial time stamp meets or exceeds the development time for the test cartridge; and a detector for detecting emissions from an up-converting phosphor in the one or more target capture zones. |
| FILED | Thursday, August 10, 2017 |
| APPL NO | 16/319685 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/54 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 2200/143 (20130101) B01L 2300/022 (20130101) B01L 2300/0663 (20130101) B01L 2300/0681 (20130101) B01L 2300/0825 (20130101) B01L 2400/0406 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101) G01N 2201/0612 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210331925 | Sridharan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizon State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arati Sridharan (Chandler, Arizona); Jitendran Muthuswamy (Chandler, Arizona) |
| ABSTRACT | A soft conductive composition can include: a crosslinked silicone composition; and single-walled or multi-walled carbon nanotubes in the silicone composition. A neural probe or other implant can include the soft conducive composition on a least a portion of the implant body. A method of making an implant can include: selecting PDMS precursors; cross-linking the PDMS precursor to obtain an elastic modulus of about 3-9 kPa or +/−1%, 5%, 10%, 20%, or 50%; selecting the carbon nanotubes; introducing the carbon nanotubes into the crosslinked PDMS to form a soft conductive composite composition; and coating the soft conductive composite composition onto at least a portion of an implant. A method of measuring properties at a neural interface can include: providing a neural probe having a soft conductive composition; implanting the neural probe having the soft conductive composition at a neural interface; and measuring a property with the neural probe. |
| FILED | Friday, August 04, 2017 |
| APPL NO | 16/322759 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/686 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/174 (20170801) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/61 (20180101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332007 | ZHANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Triangle Institute (Research Triangle Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanan ZHANG (Apex, North Carolina); Thuy NGUYEN (Morrisville, North Carolina); Nadezhda GERMAN (Amarillo, Texas) |
| ABSTRACT | The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1. |
| FILED | Wednesday, July 07, 2021 |
| APPL NO | 17/369088 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/30 (20180101) Acyclic or Carbocyclic Compounds C07C 275/38 (20130101) Original (OR) Class Heterocyclic Compounds C07D 205/04 (20130101) C07D 207/335 (20130101) C07D 211/38 (20130101) C07D 213/643 (20130101) C07D 215/12 (20130101) C07D 239/26 (20130101) C07D 295/135 (20130101) C07D 333/20 (20130101) C07D 487/08 (20130101) C07D 491/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332011 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiaming LI (Pasadena, California); Xu CHEN (Pasadena, California); Tonia S. AHMED (Pasadena, California); Brian STOLTZ (Pasadena, California); Robert H. GRUBBS (Pasadena, California) |
| ABSTRACT | This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield). |
| FILED | Tuesday, May 14, 2019 |
| APPL NO | 17/055970 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/462 (20130101) Acyclic or Carbocyclic Compounds C07C 405/0016 (20130101) Original (OR) Class C07C 2601/10 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332030 | Goldstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Alex S. Goldstein (Seattle, Washington); John K. Amory (Seattle, Washington); Jisun Paik (Seattle, Washington); Michael Haenisch (Seattle, Washington); Nina Isoherranen (Seattle, Washington); Piper Treuting (Seattle, Washington); Charles H. Muller (Seattle, Washington) |
| ABSTRACT | Pyrazole compounds and piperazine compounds that are inhibitors of ALDH1A1 and ALDH1A2 and methods for using the pyrazole compounds and piperazine compounds in male contraceptive compositions for preventing spermatogenesis. |
| FILED | Thursday, December 12, 2019 |
| APPL NO | 17/262877 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/16 (20180101) Heterocyclic Compounds C07D 231/14 (20130101) C07D 403/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332046 | Horenstein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Alana Horenstein (High Springs, Florida); Roger Lee Papke (Gainesville, Florida); Marta Quadri (Vigano, Italy) |
| ABSTRACT | Derivatives of N,N-diethyl-N′-phenyl-piperazine, a silent agonist of the mammalian α7 nicotinic acetylcholine receptor, are provided. These silent agonists control the desensitization state of the receptor. Further provided are pharmaceutical compositions that allow the administration of the silent agonists of the disclosure to a subject animal or human in need of treatment for a pathological condition arising from such as inflammation. The novel silent agonists also may be co-administered to a patient simultaneously or consecutively with a type II positive allosteric modulator to modulate the activity of the receptor. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370634 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/452 (20130101) A61K 31/495 (20130101) A61K 31/499 (20130101) Heterocyclic Compounds C07D 211/58 (20130101) C07D 211/70 (20130101) C07D 295/037 (20130101) C07D 295/073 (20130101) C07D 295/096 (20130101) C07D 295/155 (20130101) C07D 471/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332048 | Ong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kala Pharmaceuticals, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Winston Zapanta Ong (Stoneham, Massachusetts); Pawel Wojciech Nowak (Woodcliff Lake, New Jersey); Jinsoo Kim (Brighton, Massachusetts); Elizabeth M. Enlow (Waltham, Massachusetts); James Bourassa (Somerville, Massachusetts); Yen Cu (Cambridge, Massachusetts); Alexey Popov (Waltham, Massachusetts); Hongming Chen (Belmont, Massachusetts) |
| ABSTRACT | The present invention provides novel derivative of β-lactam antibiotics, such as meropenem. The inventive compounds include compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are particles (e.g., nanoparticles) and pharmaceutical compositions thereof that are mucus penetrating. The inventive particles and pharmaceutical compositions may be useful in delivering an inventive compound to the respiratory tract of a subject. The invention further provides methods of using and kits including the inventive compounds, particles thereof, and/or pharmaceutical compositions thereof for treating and/or preventing a pulmonary disease (e.g., a respiratory tract infection). |
| FILED | Wednesday, July 07, 2021 |
| APPL NO | 17/369806 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5015 (20130101) A61K 9/5031 (20130101) A61K 9/5123 (20130101) A61K 9/5146 (20130101) A61K 31/407 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 477/20 (20130101) Original (OR) Class C07D 487/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332051 | HUANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NOVITA PHARMACEUTICALS, INC. (New York, New York); CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xin-Yun HUANG (New York, New York); Christy Young SHUE (Irvine, California) |
| ABSTRACT | Provided are compositions and methods for treating a condition or disorder mediated by fascin activity in a subject in need thereof which method comprises administering to the subject a therapeutically effective amount of at least one compound of any one of Formula I-a to I-n, II, II-a, II-b or III or a pharmaceutically acceptable salt thereof. |
| FILED | Thursday, January 28, 2021 |
| APPL NO | 17/160948 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/428 (20130101) A61K 31/433 (20130101) A61K 31/522 (20130101) Heterocyclic Compounds C07D 249/12 (20130101) C07D 277/82 (20130101) C07D 285/08 (20130101) C07D 405/12 (20130101) C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332062 | Guzman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BioVentures, LLC (Little Rock, Arkansas); Cornell University (Ithaca, New York); New York Botanical Garden (Bronx, New York) |
| ASSIGNEE(S) | Board of Trustees of the University of Arkansas (Little Rock, Arkansas) |
| INVENTOR(S) | Monica L. Guzman (Ithaca, New York); Cesar M. Compadre (Little Rock, Arkansas); Paola E. Ordonez (Little Rock, Arkansas); Mariano Martinez (Little Rock, Arkansas); Michael J. Balick (Bronx, New York); Darin E. Jones (Little Rock, Arkansas); Flavio G. Gaudio (Ithaca, New York) |
| ABSTRACT | The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/334098 |
| CURRENT CPC | Heterocyclic Compounds C07D 307/93 (20130101) C07D 493/04 (20130101) C07D 493/08 (20130101) C07D 493/10 (20130101) Original (OR) Class C07D 493/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332076 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Liu (Chapel Hill, North Carolina); Jine Li (Chapel Hill, North Carolina); Guowei Su (Durham, North Carolina) |
| ABSTRACT | Methods of synthesizing chondroitin sulfate oligosaccharides are provided. Enzymatic schematic approaches to synthesizing structurally defined homogenous chondroitin sulfate oligosaccharides at high yields are provided. Synthetic chondroitin sulfate oligosaccharides ranging from 3-mers to 15-mers are provided. |
| FILED | Tuesday, July 03, 2018 |
| APPL NO | 16/625342 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 3/06 (20130101) Original (OR) Class Polysaccharides; Derivatives Thereof C08B 37/0069 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/13 (20130101) C12N 9/1048 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332083 | Cai |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hua Cai (Los Angeles, California) |
| ABSTRACT | Disclosed herein are netrin-1 compounds and compositions thereof and methods of using thereof to treat pulmonary hypertension. In some embodiments, the present invention provides methods of treating, reducing, or inhibiting pulmonary hypertension or reducing a subjects mean pulmonary arterial pressure (mPAP) and/or the subjects right ventricular systolic pressure (RVSP), which methods comprise administering to the subject a therapeutically effective amount of one or more netrin-1 compounds. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 17/286857 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332090 | MALLEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Richard MALLEY (Beverly, Massachusetts); Yingjie LU (West Roxbury, Massachusetts); Fan ZHANG (West Roxbury, Massachusetts) |
| ABSTRACT | The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 16/945714 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/092 (20130101) A61K 39/385 (20130101) A61K 47/61 (20170801) A61K 47/543 (20170801) A61K 47/557 (20170801) A61K 2039/6031 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/31 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332093 | POZZI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); The United States as Represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ambra A. POZZI (Nashville, Tennessee); Manuel CHIUSA (Nashville, Tennessee); Jack J. HAWIGER (Nashville, Tennessee); Jozef ZIENKIEWICZ (Nashville, Tennessee) |
| ABSTRACT | Disclosed herein are compositions and methods for inhibiting collagen production mediated by the Fused in Sarcoma (FUS) ribonucleoprotein. As disclosed herein, the C terminal domain of FUS contains an uncommon nuclear localization sequence (NLS) motif called PY-NLS that binds the nuclear import receptor transportin. Phosphorylation of FUS leads to its association with transportin and nuclear translocation with consequent increased in collagen production. Therefore, disclosed herein is an isolated peptide having a transportin-binding moiety, which inhibits FUS from binding transportin, linked to a membrane translocating motif. These compositions and methods can be used to inhibit FUS-mediated collagen production, and treat fibrotic disease involving FUS-mediated collagen accumulation in kidneys and other organs displaying fibrotic diseases. |
| FILED | Monday, January 29, 2018 |
| APPL NO | 16/481128 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 38/1777 (20130101) A61K 38/1825 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Peptides C07K 14/50 (20130101) C07K 14/4703 (20130101) Original (OR) Class C07K 14/70557 (20130101) C07K 2319/02 (20130101) C07K 2319/10 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332095 | Voth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Alabama (Mobile, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah Voth (Mobile, Alabama); Troy Stevens (Mobile, Alabama); Ron Balczon (Mobile, Alabama); Kyle Adam Morrow (Mobile, Alabama) |
| ABSTRACT | The present disclosure relates to compositions and methods for the production of antimicrobial amyloid compositions, and further relates to use of such antimicrobial preparations for the treatment of subjects having drug-resistant microbial infections. Advantageous and/or therapeutic amyloid oligomer immunodepletion methods are also disclosed. |
| FILED | Friday, September 06, 2019 |
| APPL NO | 17/273940 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1716 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/4711 (20130101) Original (OR) Class C07K 16/18 (20130101) C07K 2317/76 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332110 | Nussenzweig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Rockefeller University (New York, New York) |
| INVENTOR(S) | Michel Nussenzweig (New York, New York); Davide F. Robbiani (New York, New York) |
| ABSTRACT | This disclosure provides novel broadly neutralizing anti-SARS-CoV-2 antibodies or antigen-binding fragments thereof. The disclosed anti-SARS-CoV-2 antibodies constitute a novel therapeutic strategy in protection from SARS-CoV-2 infections. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242583 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/33 (20130101) C07K 2317/35 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332111 | Diamond et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Loui, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael S. Diamond (St. Louis, Missouri); Daved Fremont (St. Louis, Missouri); Haiyan Zhao (St. Louis, Missouri); Estefania Fernandez (St. Louis, Missouri); Derek Platt (St. Louis, Missouri); Christopher Nelson (St. Louis, Missouri) |
| ABSTRACT | The present disclosure relates to antibodies specific to Zika virus and methods for detecting Zika virus infection in a subject. The present disclosure also relates to therapeutic antibodies useful in reducing viral load. |
| FILED | Wednesday, July 26, 2017 |
| APPL NO | 16/320872 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1081 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332118 | Clauss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthias Clauss (Indianapolis, Indiana); Irina Petrache (Indianapolis, Indiana); Robert Voswinckel (Geissen, Germany) |
| ABSTRACT | The present invention provides methods for diagnosing a patient with emphysema, COPD of lung injury caused by tobacco use by detecting the levels of EMAP II in a sample. Disclosed herein are the hypervariable regions for a rat monoclonal antibody that binds to a form of EMAP II. This disclosure also includes a polypeptide sequence included in EMAP II that is the target for the binding of the antibody to its target protein. This epitope serves as the basis for a humanized antibody that can be used to treat patients that suffer from pathologies that exhibit elevated levels of EMAP II expression. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/198031 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) C07K 16/22 (20130101) Original (OR) Class C07K 16/2866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332122 | MCGOVERN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dermot MCGOVERN (Los Angeles, California); Alka POTDAR (Cumming, Georgia); Shishir DUBE (Los Angeles, California) |
| ABSTRACT | Provided herein are methods, systems and kits for use in identifying a subject with an increased risk of developing severe forms of inflammatory bowel disease (IBD), based at least in part, on an expression of one or more biomarkers detected in a biological sample obtained from the subject. Also provided are methods, systems and kits for treating, or optimizing the treatment for, the IBD based, at least in part, on the expression the one or more biomarkers. In some embodiments, the one or more biomarkers is angiotensin-converting enzyme 2 (ACE2), the host receptor for severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2). |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/232987 |
| CURRENT CPC | Peptides C07K 16/241 (20130101) C07K 16/244 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/705 (20130101) G01N 2333/912 (20130101) G01N 2333/948 (20130101) G01N 2800/52 (20130101) G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332130 | KUCHROO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Vijay K. KUCHROO (Newton, Massachusetts); Ana C. ANDERSON (Newton, Massachusetts) |
| ABSTRACT | Described herein are novel compositions comprising bispecific and multispecific polypeptide agents, and methods using these agents for targeting cells, such as functionally exhausted or unresponsive immune cells, that co-express the inhibitory receptors PD-1 and TIM-3. These compositions and methods are useful for the treatment of chronic immune conditions, such as persistent infections or cancer. |
| FILED | Tuesday, February 02, 2021 |
| APPL NO | 17/165120 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/28 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332136 | CURIEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Development Foundation (Carson City, Nevada) |
| ASSIGNEE(S) | Research Development Foundation (Carson City, Nevada) |
| INVENTOR(S) | Tyler J. CURIEL (San Antonio, Texas); Anand Kornepati (San Antonio, Texas) |
| ABSTRACT | Provided herein are methods for the diagnosis, assessment, and treatment of cancer. In some aspects, detection of intracellular or cytoplasmic PD-L1, or measuring the ratio of cytoplasmic to surface PD-L1, can be used to identify cancers that may respond to immunotherapies or a DDR inhibitor such as, e.g., a Chk1 inhibitor, a PARP inhibitor, an ATM inhibitor, or an ATR inhibitor. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200729 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/196 (20130101) A61K 31/437 (20130101) A61K 31/519 (20130101) A61K 31/675 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 2333/4703 (20130101) G01N 2800/7028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332141 | Beltran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pinchas Cohen (Pacific Palisades, California); AMGEN INC. (Thousand Oaks, California); Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pedro Beltran (Thousand Oaks, California); Derek Huffman (Bronx, New York); Nir Brazilal (Bronx, New York); Pinchas Cohen (Pacific Palisades, California) |
| ABSTRACT | The present disclosure provides a method of improvement, preservation, prophylaxis, or inhibition-of-deterioration of a healthspan parameter of a mammalian subject. In exemplary embodiments, the method comprises administering to the subject a composition that comprises an insulin-like growth factor-1 receptor (IGF-1 R) inhibitor, wherein the composition is administered in an amount effective to improve, provide prophylaxis for, or inhibit-the-deterioration of the healthspan parameter. |
| FILED | Thursday, August 30, 2018 |
| APPL NO | 16/640006 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/566 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/55 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 5/30 (20180101) Peptides C07K 16/2863 (20130101) Original (OR) Class C07K 2317/51 (20130101) C07K 2317/76 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210332206 — REGIOSELECTIVE C-H XANTHYLATION AS A PLATFORM TECHNOLOGY FOR POLYMER FUNCTIONALIZATION
| US 20210332206 | Alexanian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erik Alexanian (Chapel Hill, North Carolina); Frank Albert Leibfarth (Carrboro, North Carolina); Jill Williamson (Chapel Hill, North Carolina); Will Czaplyski (Cambridge, Massachusetts) |
| ABSTRACT | The subject matter described herein relates to methods for polymer xanthylation and the xanthylated polymers produced by such methods. Subsequent replacement of the xanthylate moiety allows facile entry into functionalized polymers. |
| FILED | Wednesday, October 03, 2018 |
| APPL NO | 16/753390 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 10/02 (20130101) C08F 10/06 (20130101) C08F 10/10 (20130101) C08F 2810/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/912 (20130101) C08G 64/42 (20130101) C08G 65/3348 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 7/12 (20130101) Original (OR) Class C08J 2323/26 (20130101) C08J 2323/36 (20130101) C08J 2367/04 (20130101) C08J 2369/00 (20130101) C08J 2371/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332331 | Bahou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wadie F. Bahou (Setauket, New York); Patrick Hearing (Saint James, New York); Varsha Sitaraman (Stony Brook, New York) |
| ABSTRACT | The invention provides adeno-associated virus (AAV) replication (Rep) sequences. In one embodiment, the invention provides nucleotide sequences encoding a chimeric protein, wherein the encoded chimeric protein contains a wild type AAV Rep inhibitory amino acid sequence, and wherein the nucleotide sequences contain a scrambled and/or deoptimized polynucleotide sequence encoding the wild type AAV Rep inhibitory amino acid sequence. The invention provides vectors, cells, and viruses containing the invention's sequences. Also provided are methods for detecting portions of the AAV Rep inhibitory amino acid sequence, which reduce replication and/or infection and/or productive infection by viruses. The invention's compositions and methods are useful for site-specific integration and/or expression of heterologous sequences by recombinant adeno-associated virus (rAAV) vectors and by rAAV virus particles, such as hybrid viruses (e.g., Ad-AAV) comprising such vectors. The invention's compositions and methods find application in, for example, gene therapy and/or vaccines. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167743 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 2039/5256 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 9/16 (20130101) C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 2710/10343 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2840/60 (20130101) C12N 2840/102 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332333 | Stafford et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrel W. Stafford (Carrboro, North Carolina); Tao Li (San Diego, California) |
| ABSTRACT | The present invention provides a stable cell line overexpressing a recombinant vitamin K-dependent (VKD) protein and both a recombinant vitamin K epoxide reductase (VKOR) and a recombinant vitamin K dependent gamma carboxylase (VKGC), wherein the amount of fully carboxylated VKD protein produced in the cell is increased 10% as compared to the amount of fully carboxylated VKD protein produced in the cell in the absence of the recombinant VKOR and the recombinant VKGC. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 16/951320 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) Original (OR) Class C12N 9/50 (20130101) C12N 9/64 (20130101) C12N 9/88 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/172 (20130101) Enzymes C12Y 101/04001 (20130101) C12Y 304/21006 (20130101) C12Y 401/0109 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332338 | Jantz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Derek Jantz (Durham, North Carolina); Michael G. Nicholson (Chapel Hill, North Carolina); James Jefferson Smith (Morrisville, North Carolina) |
| ABSTRACT | Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional effectors can comprise (i) a meganuclease DNA-binding domain lacking endonuclease cleavage activity that binds to a target recognition site; and (ii) a transcription effector domain. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/224054 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 14/4702 (20130101) C07K 14/4703 (20130101) C07K 2319/09 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332344 | Yeo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Yeo (La Jolla, California); Kristopher Brannan (La Jolla, California) |
| ABSTRACT | Described herein are compositions, systems, methods, and kits utilizing CRISPR-Cas protein fusions comprising a guide nucleotide sequence-programmable RNA binding protein and a RNA base modification protein. The compositions, systems, methods, and kits described herein are useful to modulate RNA methylation and/or cytidine deamination. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 17/272009 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/50 (20130101) A61K 38/465 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Enzymes C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332357 | Kieft et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey S. Kieft (Denver, Colorado); Erich G. Chapman (Denver, Colorado); David A. Costantino (Denver, Colorado); Jay R. Hesselberth (Denver, Colorado); Andrea McFadden (Denver, Colorado); Benjamin Akiyama (Denver, Colorado) |
| ABSTRACT | This invention is in the field of molecular biology, gene expression, functional genomics, and bioinformatics and relates to novel RNA and related structures and methods of use thereof that enables modulation of gene expression and preservation of particular transcriptome targets. The invention contemplates various applications of RNA sequences derived from the genomic RNA of flaviviruses (FVs) and the application of such features in combination with heterologous sequences. |
| FILED | Thursday, February 11, 2021 |
| APPL NO | 17/173354 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/18 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332359 | Medarova et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zdravka Medarova (Methuen, Massachusetts); Byunghee Yoo (Lexington, Massachusetts) |
| ABSTRACT | Therapeutic compositions and methods for treating cancer, e.g., pancreatic cancer, that use nanoparticles linked to inhibitory nucleic acids, e.g., siRNAs, targeting an immune checkpoint molecule, e.g., programmed cell death 1 ligand 1 (PD-L1). |
| FILED | Friday, September 06, 2019 |
| APPL NO | 17/273954 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7068 (20130101) A61K 47/6923 (20170801) A61K 47/6939 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332387 | Stevenson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Oregon (Eugene, Oregon) |
| ASSIGNEE(S) | University of Oregon (Eugene, Oregon) |
| INVENTOR(S) | Zachary C. Stevenson (Eugene, Oregon); Stephen A. Banse (Eugene, Oregon); Patrick C. Phillips (Eugene, Oregon) |
| ABSTRACT | Provided herein are genetically modified cells and methods of their production, wherein such methods include introducing a nucleic acid molecule including a plurality of index sequences into a cell comprising a synthetic landing pad, wherein each of the plurality of index sequences includes a first portion of a sequence and the synthetic landing pad includes a second portion of the sequence. The method further includes generating a plurality of cells that include the synthetic landing pad and the nucleic acid molecule including the plurality of index sequences and integrating one of the plurality of index sequences into the synthetic landing pad in each of the cells, thereby linking the first and second portions of the sequence. The linked first and second portions of the sequence result in a functional gene and cells including the integrated index sequence are selected based on presence or activity of the functional gene. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236556 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/902 (20130101) Original (OR) Class C12N 15/8509 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332390 | Doudna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emmanuelle Charpentier (Berlin, Germany); The Regents of the University of California (Oakland, California); University of Vienna (Vienna, Austria) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Martin Jinek (Berkeley, California); Krzysztof Chylinski (Vienna, Austria); Emmanuelle Charpentier (Berlin, Germany) |
| ABSTRACT | The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/326791 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/4684 (20180501) Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/746 (20130101) C12N 15/902 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/13 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Enzymes C12Y 301/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332391 | Doudna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emmanuelle Charpentier (Berlin, Germany); The Regents of the University of California (Oakland, California); University of Vienna (Vienna, Austria) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Martin Jinek (Berkeley, California); Krzysztof Chylinski (Vienna, Austria); Emmanuelle Charpentier (Berlin, Germany) |
| ABSTRACT | The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/326818 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/4684 (20180501) Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/746 (20130101) C12N 15/902 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/13 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Enzymes C12Y 301/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332401 | Matsui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York); Japanese Foundation for Cancer Research (Tokyo, Japan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroshi Matsui (Glen Rock, New Jersey); Kiyotaka Shiba (Tokyo, Japan); Min A. Kang (Flushing, New York) |
| ABSTRACT | A method for enhancing extracellular vesicle production is described. A peptide that induces polymer formation is incubated with a cell culture which results in enhanced EV production. The peptide penetrates the cells and subsequently polymerizes upon exposure to enzymes (e.g. phosphatase) within the cell. The cells that contain the newly formed polymers have an increased production of EVs. These EVs can be harvested using centrifugation techniques. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/366950 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0006 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332414 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Jehyuk Lee (Allston, Massachusetts); Daniel Levner (Boston, Massachusetts); Michael Super (Lexington, Massachusetts) |
| ABSTRACT | Methods of making a three-dimensional matrix of nucleic acids within a cell is provided. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/366127 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332415 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Jehyuk Lee (Allston, Massachusetts); Daniel Levner (Boston, Massachusetts); Michael Super (Lexington, Massachusetts) |
| ABSTRACT | Methods of making a three-dimensional matrix of nucleic acids within a cell is provided. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/366151 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333177 | Deerinck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Deerinck (La Jolla, California); Mark Ellisman (La Jolla, California); Steven Peltier (La Jolla, California) |
| ABSTRACT | An epoxy resin-based embedding media doped with a non-conductive dopant to a predetermined w/w % such that the media is non-charging at 1.8 keV. A preferred dopant is polyethylene glycol at a molecular weight of at least 3350, and having a predetermined w/w % is at least 2% and up to 20%, most preferably from 2% to 10%. Another preferred dopant is polyethylene glycol at a molecular weight of 7000-8000 and a predetermined w/w % of up to ˜40% and more preferably of up to ˜30%. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238530 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) C08K 2003/222 (20130101) Compositions of Macromolecular Compounds C08L 63/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 23/2251 (20130101) G01N 2001/305 (20130101) G01N 2223/309 (20130101) Pictorial Communication, e.g Television H04N 7/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333241 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Lihong Wang (Arcadia, California); Liang Song (St. Louis, Missouri); Konstantin Maslov (Pasadena, California); Bin Rao (St. Louis, Missouri) |
| ABSTRACT | A probe for use with an imaging system, including a scanning device configured to receive a first light beam from a light source, a beam-divider configured to split the first light beam into a plurality of second light beams, and a focusing device configured to focus each of the second light beams on respective locations in an object of interest is disclosed. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/302313 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/42 (20130101) A61B 5/0095 (20130101) A61B 5/441 (20130101) A61B 5/4064 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/2418 (20130101) Original (OR) Class G01N 2291/028 (20130101) G01N 2291/106 (20130101) Optical Elements, Systems, or Apparatus G02B 21/36 (20130101) G02B 26/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333263 | GAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinming GAO (Plano, Texas); Zhaohui WANG (Dallas, Texas); Min LUO (Irving, Texas); Qi WEI (Dallas, Texas); Gang HUANG (Plano, Texas) |
| ABSTRACT | Provided herein are compounds of the formula: (I) wherein the variables are defined herein, which may be used as redox-activatable sensors. In some aspects, the compounds are fluorescence sensors which are activated by the redox state of the cell. Also provided herein are methods of using these compounds to image the cellular environment or the delivery of macromolecules to a cell. |
| FILED | Tuesday, September 12, 2017 |
| APPL NO | 16/333164 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/07 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/502 (20130101) Original (OR) Class G01N 33/542 (20130101) G01N 2021/6432 (20130101) G01N 2021/6439 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333284 | YANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danzhou YANG (West Lafayette, Indiana); Guanhui WU (West Lafayette, Indiana); Charles VINSON (Bethesda, Maryland) |
| ABSTRACT | Described herein are devices and processes using single-stranded DNA sequences capable of forming G-quadruplexes (G4s) to assess the binding affinity and binding selectivity of potential G4-interactive ligands. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/241912 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/68 (20130101) Original (OR) Class G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333308 | Franceschini et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maria A. Franceschini (Winchester, Massachusetts); Adriano Peruch (Cambridge, Massachusetts); Kuan Cheng Wu (Boston, Massachusetts); Marco Renna (Cavallino, Italy) |
| ABSTRACT | A sensor assembly and sensing method is provided for proximity detection for assessing an attachment state of a sensing probe with respect to a subject. A probe is coupled to an electronic probe controller. The probe includes a proximity sensor having a passive energy storing circuit element, and a biological sensor receptacle configured to receive a biological sensor for sensing a biological characteristic of an object. The electronic probe controller excites a circuit network incorporating the proximity sensor with an excitation signal and determines a characteristic of the circuit network that is excited by the excitation signal. The electronic probe controller further generates a proximity indication indicating whether the probe is attached to the object based on the characteristic of the circuit network. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240148 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 1/0735 (20130101) G01R 1/06766 (20130101) G01R 1/06794 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333343 | Dosenbach |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NOUS IMAGING, INC. (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nico Dosenbach (St. Louis, Missouri) |
| ABSTRACT | A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity. |
| FILED | Wednesday, December 09, 2020 |
| APPL NO | 17/116827 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/7246 (20130101) A61B 2576/026 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) Original (OR) Class G01R 33/56366 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333396 | IZATT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph IZATT (Durham, North Carolina); Ruobing QIAN (Durham, North Carolina); Kevin ZHOU (Durham, North Carolina) |
| ABSTRACT | A 3D sensing depth camera involves a time-frequency multiplexed frequency-modulated continuous wave (FMCW) LiDAR technique. A sample arm of such a system for 3D depth sensing includes a scanner for beam scanning in a first axis and a diffractive optical element for spectrally encoded scanning along a second axis. The sample arm can further include beam shaping optics such as a collimator and a lens. Processing of an interferogram comprising depth information at a different position along the second axis for each frequency sweep of the light source involves applying a windowed spectral estimator at a particular spectral window size with zero-padding and according to a specified lateral sampling approach. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238521 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/42 (20130101) Original (OR) Class G01S 17/89 (20130101) Optical Elements, Systems, or Apparatus G02B 5/1866 (20130101) G02B 27/30 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/20 (20130101) G06T 7/521 (20170101) G06T 2207/10028 (20130101) G06T 2207/20032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210334663 | Shen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xipeng Shen (Raleigh, North Carolina); Hui Guan (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure describes various embodiments of methods and systems of training a pruned neural network. One such method comprises defining a plurality of tuning blocks within a neural network, wherein a tuning block is a sequence of consecutive convolutional neural network layers of the neural network; pruning at least one of the plurality of tuning blocks to form at least one pruned tuning block, and pre-training the at least one pruned tuning block to form at least one pre-trained tuning block. The method further comprises assembling the at least one pre-trained tuning block with other ones of the plurality of tuning blocks of the neural network to form a pruned neural network; and training the pruned neural network, wherein the at least one pre-trained tuning block is initialized with weights resulting from the pre-training of the at least one pruned tuning block. Other methods and systems are also provided. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242691 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6228 (20130101) Computer Systems Based on Specific Computational Models G06N 3/082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210334960 | Arnold et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Corey Arnold (Oakland, California); King Chung Ho (Oakland, California); Fabien Scalzo (Oakland, California) |
| ABSTRACT | Systems and methods for analyzing perfusion-weighted medical imaging using deep neural networks are provided. In some aspects, a method includes receiving perfusion-weighted imaging data acquired from a subject using a magnetic resonance (“MR”) imaging system and modeling at least one voxel associated with the perfusion-weighted imaging data using a four-dimensional (“4D”) convolutional neural network. The method also includes extracting spatio-temporal features for each modeled voxel and estimating at least one perfusion parameter for each modeled voxel based on the extracted spatio-temporal features. The method further includes generating a report using the at least one perfusion parameter indicating perfusion in the subject. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242930 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0263 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 2209/05 (20130101) Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) G06N 5/046 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2200/04 (20130101) G06T 2207/10096 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30016 (20130101) G06T 2207/30096 (20130101) G06T 2207/30104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210330240 | SCHALK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Health Research, Inc. (Menands, New York); Albany Medical College (Albany, New York) |
| ASSIGNEE(S) | Health Research, Inc. (Menands, New York); Albany Medical College (Albany, New York) |
| INVENTOR(S) | Gerwin SCHALK (Glenmont, New York); Anthony L. RITACCIO (Voorheesville, New York); Adriana DE PESTERS (Coppet, Switzerland); AmiLyn TAPLIN (Albany, New York) |
| ABSTRACT | Provided is a method for mapping a neural area involved in speech processing, including applying a plurality of recording electrodes to a surface of a cortex of a human subject, presenting a plurality of auditory stimuli to the subject wherein some of the plurality of stimuli are speech sounds and others of the plurality of auditory stimuli are non-speech sounds, recording brain activity during the presenting of the plurality of auditory stimuli, and identifying one or more brain areas wherein activity changes more after presentation of speech sounds than it does after presentation of non-speech sounds, wherein the human subject does not speak during the presenting and the recording. Also provided is a method for mapping a neural area involved in speech production wherein the human subject does not speak during presenting speech stimuli and recording neural activity. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 17/365032 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/38 (20210101) Original (OR) Class A61B 5/4064 (20130101) A61B 5/4094 (20130101) A61B 2505/05 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/32 (20130101) A61N 1/0531 (20130101) A61N 1/36082 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330734 | Venn-Watson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EPITRACKER, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie Venn-Watson (San Diego, California) |
| ABSTRACT | Compositions including small molecule biochemicals, and salts and derivatives thereof, and methods for detection, treatment or prophylaxis of neurodegenerative diseases are provided, including compositions and methods for detecting and treating conditions that contribute to neurodegenerative diseases, including peripheral and central inflammation, amyloid-β plaque deposition in the brain, neuronal iron deposition and hyperglycemia. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370231 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/20 (20130101) A61K 31/047 (20130101) A61K 31/197 (20130101) A61K 31/198 (20130101) A61K 31/205 (20130101) A61K 31/575 (20130101) A61K 31/7004 (20130101) A61K 31/7032 (20130101) A61K 31/7076 (20130101) A61K 38/05 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330773 | Lyerly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Herbert K. Lyerly (Durham, North Carolina); Michael A. Morse (Durham, North Carolina); Takuya Osada (Durham, North Carolina); Timothy M. Clay (Waterloo, Belgium); Zachary C. Hartman (Durham, North Carolina) |
| ABSTRACT | Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent, such as a checkpoint inhibitor and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding a HER3 polypeptide. Methods of using the vaccine including the polynucleotide encoding the HER3 polypeptide to treat a cancer or precancer are also provided. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/328953 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 39/001106 (20180801) Original (OR) Class A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/53 (20130101) A61K 2039/505 (20130101) A61K 2039/507 (20130101) A61K 2039/585 (20130101) A61K 2039/5256 (20130101) Peptides C07K 16/32 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/77 (20130101) C07K 2317/734 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330920 | Bowen |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States as Represented by the Secretary of the Army (Ft. Detrick, Maryland) |
| ASSIGNEE(S) | The Government of the United States as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| INVENTOR(S) | Larry E. Bowen (Williamsport, Maryland) |
| ABSTRACT | In at least one embodiment, a system includes an inhalation source; a plenum in fluid communication with the inhalation source; at least one challenge plethysmography mask in fluid communication with the plenum, for each challenge plethysmography mask including a mask having a cavity to receive at least a nose of a test animal, a delivery conduit in fluid communication with the plenum and the cavity of the mask, at least one exhaust conduit in fluid communication with the cavity of the mask and the plenum, and a pressure sensor attached to the mask to measure pressure within the cavity of the mask; at least one processor in electrical communication with the at least one pressure sensor, the processor configured to process an output signal of the pressure sensor into respiratory data for each test animal during an exposure study; and an exhaust system in fluid communication with the plenum. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318905 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/091 (20130101) A61B 5/4821 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/06 (20130101) Original (OR) Class A61M 16/085 (20140204) A61M 2250/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330922 | Boston et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Andrew G. Boston (Silver Spring, Maryland); Mostafa M. Ahmed (Belton, Texas); Thomas J. Wilson (Boerne, Texas); Erik K. Weitzel (San Antonio, Texas) |
| ABSTRACT | A negative pressure surgical apparatus. The apparatus includes a mask configured to cover a portion of the face of a patient and including a first port and an instrument port. The first port is configured to draw negative pressure from between the mask and the face of the patient. The instrument port is configured to receive a medical instrument therethrough and form a seal therewith. The instrument port is positioned on the mask so as to permit surgery at a surgical site. |
| FILED | Wednesday, August 05, 2020 |
| APPL NO | 16/985829 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/009 (20130101) A61M 16/047 (20130101) A61M 16/205 (20140204) A61M 16/208 (20130101) A61M 16/0468 (20130101) A61M 16/0622 (20140204) Original (OR) Class A61M 16/0683 (20130101) A61M 2209/088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210331110 | Roth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | USA as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | USA as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Marc L. Roth (Owens Cross Roads, Alabama); William J Spangler, JR. (Forest Hill, Michigan); Lester D Strauch, III (Churchville, Maryland); Patrick O Hulbert (Dallastown, Pennsylvania); Robert Michael Ferguson (Baytown, Texas) |
| ABSTRACT | The present disclosure provides a filter cartridge for a facepiece respirator mask body. The filter cartridge includes a cover, a base, and a filter medium. The cover has a top surface, a cover sidewall, cover support elements, and an inhalation vent. The cover support elements extend downwardly from the top surface. The inhalation vent is located at least primarily in the cover sidewall. The base has a bottom surface, a base sidewall, base support elements, and an inhalation port. The base support elements extend upwardly from the bottom surface. The inhalation port is located in the bottom surface. The base and the cover collectively define an interior compartment. The filter medium is sandwiched between the base support elements and the cover support elements in a manner that divides the interior compartment into an upper chamber and a lower chamber. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237247 |
| CURRENT CPC | Devices, Apparatus or Methods for Life-saving A62B 23/02 (20130101) Separation B01D 46/0004 (20130101) B01D 46/0005 (20130101) B01D 46/10 (20130101) B01D 46/0045 (20130101) Original (OR) Class B01D 2265/028 (20130101) B01D 2279/65 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210331155 | SILVER |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SYRACUSE UNIVERSITY (Syracuse, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert B. SILVER (Syracuse, New York) |
| ABSTRACT | A system for collecting, growing, and analyzing biological specimens that may present a health threat. The system includes separate modules for specimen collection, sample isolation, and sample analysis that can be interconnected to safety process, culture, and analyze and unknown specimen. A decapitation module allows a user to safely collect a swab tip containing an unknown sample and transport the sample to a culture module where the sample can be washed from the swab tip and isolated in a cuvette for growth and analysis. The culture module may be coupled to a base station that can provide mixing, heating and cooling, as well as optical and spectral analysis. |
| FILED | Thursday, May 03, 2018 |
| APPL NO | 16/613987 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5029 (20130101) Original (OR) Class B01L 7/00 (20130101) B01L 2200/025 (20130101) B01L 2200/141 (20130101) B01L 2300/087 (20130101) B01L 2300/0681 (20130101) B01L 2300/1822 (20130101) B01L 2400/065 (20130101) B01L 2400/0644 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210331374 | Ware et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Taylor H. Ware (Dallas, Texas); Cedric P. Ambulo (Plano, Texas); Mohand O. Saed (Dallas, Texas); Jennifer M. Boothby (Plano, Texas); Julia J. Henricks (Dallas, Texas); Ravi Shankar Meenakshisundaram (Aspinwall, Pennsylvania) |
| ABSTRACT | A method of ink-extrusion printing an object, including providing a mixture including liquid crystal monomers and photo-catalyzing or heating the mixture to produce a liquid crystal ink. The ink is in a nematic phase. The method includes extruding the ink through a print-head orifice moving along a print direction to form an extruded film of the object. The extruded film exhibits birefringence. Also disclosed are a liquid crystal ink. The ink includes a mixture including liquid crystal monomers. The mixture when at a target printing temperature is in a nematic phase. Also disclosed is ink-extrusion-printed object. The object includes an extrusion-printed film including a nematic liquid crystal elastomer, wherein the film exhibits birefringence along an extrusion axis of the film. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238771 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) Original (OR) Class B29C 64/112 (20170801) B29C 71/04 (20130101) B29C 2035/0827 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/101 (20130101) C09D 11/107 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332070 | Chaput et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Chaput (Irvine, California); Jen-Yu Liao (Irvine, California); Saikat Bala (Irvine, California) |
| ABSTRACT | The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307567 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/711 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 27/138 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/091 (20130101) Original (OR) Class Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332291 | Boercker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Janice E. Boercker (Fairfax, Virginia); Sarah F. Brittman (Washington, District of Columbia); Joseph G. Tischler (Alexandria, Virginia); Patrick Y. Yee (Washington, District of Columbia); Chase T. Ellis (Silver Spring, Maryland); Paul D. Cunningham (Baltimore, Maryland); Rhonda M. Stroud (Washington, District of Columbia); Michael H. Stewart (Springfield, Virginia); Steven C. Erwin (Alexandria, Virginia) |
| ABSTRACT | A process for synthesizing Cu2-xS/PbS core/shell nanocrystals. Pb-oleate is mixed with 1-octadecene and heated to 60° C. Cu2-xS core solution and bis(trimethylsilyl)sulfide stock solution are added and the mixture is stirred at 60° C. for 6 minutes to form the PbS shell around the Cu2-xS nanocrystal cores. The flask is cooled and acetonitrile and toluene is added and the mixture is centrifuged to precipitate and remove the Cu2-xS/PbS core/shell nanocrystals from the reaction mixture. The reaction also produces homogeneously nucleated PbS nanocrystals, which are removed from the Cu2-xS/PbS core/shell reaction mixture via size-selective precipitation. By tailoring the amounts of Pb-oleate and bis(trimethylsilyl)sulfide stock solution in the reaction vessel, while maintaining their molar ratio of 1.5:1 and the number of Cu2-xS cores in the reaction, Cu2-xS/PbS core/shell nanocrystals having a predetermined shell thickness of PbS, and thus a predetermined level of chemical stability, can be obtained. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238265 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/56 (20130101) Original (OR) Class C09K 11/58 (20130101) C09K 11/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332360 | Niu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia Niu (Stanford, California); Chelsea Lyons Gordon (Stanford, California); Hyongsok Tom Soh (San Francisco, California) |
| ABSTRACT | The disclosure is directed to methods and compositions for screening a library of aptamers for aptamers having a binding affinity to a target molecule. Specifically, non-natural nucleotides can be introduced onto aptamers immobilized on the surface of beads. The non-natural nucleotides can then be subsequently chemically modified to include additional binding agents. For example, copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions can be used to introduce a wide range of binding agents onto non-natural nucleotides on beads. |
| FILED | Tuesday, June 04, 2019 |
| APPL NO | 15/734522 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2320/13 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6811 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332396 | Lyte et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Lyte (Ames, Iowa); Daniel Nicholas Villageliu (Ames, Iowa) |
| ABSTRACT | The present invention relates to nucleic acid molecules from regions of Enterococcus spp. genomes which are associated with the production of dopamine The invention also relates to proteins encoded by such nucleic acid molecules as well as nucleic acid markers which are associated with high dopamine production. Moreover, the invention relates to uses of such molecules, including, but not limited to, transforming or transfecting cells or organisms with constructs containing the nucleic acid molecules to create cells or organisms with enhanced dopamine production. The present invention is also directed to kits for identifying bacteria which may be capable of producing dopamine based on the detection of the nucleic acid molecules. |
| FILED | Monday, September 23, 2019 |
| APPL NO | 17/250878 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/001 (20130101) Original (OR) Class Enzymes C12Y 401/01025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332404 | Thaxton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | C. Shad Thaxton (Chicago, Illinois); Rohun U. Palekar (Chicago, Illinois) |
| ABSTRACT | The invention relates to biosensor for detecting and/or quantifying exercise and disease-risk associated enzymes in a biological sample and related methods. The biosensor includes a solid support and a nanostructure with a metallic core and a phospholipid shell capable of binding to a lecithin:cholesterol acyltransferase (LCAT) activator (BL-NP). |
| FILED | Thursday, June 21, 2018 |
| APPL NO | 16/625340 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) Original (OR) Class C12Q 1/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332441 | PARIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pamela PARIS (San Francisco, California); Matthew COOPERBERG (San Francisco, California); Peter CARROLL (San Francisco, California) |
| ABSTRACT | This disclosure relates to methods, computer products, computer-implemented methods, and systems for predicting the probability or risk of prostate cancer recurrence and tumor aggressiveness in a patient. The method is based, in part, on the patient's risk profile that includes the presence/degree of specific copy number variations and predictive clinical factors. The methods and systems can be used to aid in treatment selection. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222810 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332465 | Behera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | QUESTEK INNOVATIONS LLC (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit Behera (Evanston, Illinois); Greg Olson (Evanston, Illinois) |
| ABSTRACT | Exemplary martensitic steel alloys may be particularly suited for additive manufacturing applications. Exemplary atomized alloy powders usable in additive manufacturing may include carbon, nickel, manganese, chromium, and the balance iron and incidental impurities. Exemplary steel alloys can be molybdenum free. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186556 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/08 (20130101) B22F 10/28 (20210101) B22F 10/64 (20210101) B22F 2301/35 (20130101) B22F 2303/01 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Alloys C22C 38/04 (20130101) C22C 38/005 (20130101) C22C 38/50 (20130101) C22C 38/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332495 | Mirkin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chad A. Mirkin (Wilmette, Illinois); Janet R. McMillan (Evanston, Illinois); Oliver G. Hayes (Evanston, Illinois); Peter H. Winegar (Evanston, Illinois) |
| ABSTRACT | The present disclosure provides compositions comprising protein crystals and methods for programmable biomaterial synthesis. The methods of the disclosure provide the ability to organize proteins within protein crystals with control over protein orientation. |
| FILED | Friday, December 06, 2019 |
| APPL NO | 17/311108 |
| CURRENT CPC | Separation B01D 9/00 (20130101) B01D 2009/0086 (20130101) Peptides C07K 1/306 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/02 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 7/14 (20130101) Original (OR) Class C30B 29/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332537 | Polom et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathon M. Polom (Grosse Pointe Woods, Michigan); Ashley L. Genna (Macomb, Michigan); Justin S. Strickler (Clinton, Mississippi); Gary E. Johnston (Rayville, Louisiana) |
| ABSTRACT | In one embodiment, a decking system provides a surface upon which traffic may travel. Drivable decking surfaces can support heavy vehicles, such as tanks. Exemplary decking systems include a first module, a second module, a first upper fastening assembly, a first lower fastening assembly, a second upper fastening assembly, and a second lower fastening assembly. These fastening assemblies can secure the first module and the second module together. Decking systems may also include side ramp assemblies and/or end ramp assemblies, and such ramp assemblies can be coupled with a decking platform. Fastening assemblies may include a pin, a first clip, and a second clip. |
| FILED | Tuesday, April 28, 2020 |
| APPL NO | 16/861145 |
| CURRENT CPC | Construction of Bridges, or Viaducts; Assembly of Bridges E01D 2/02 (20130101) E01D 15/133 (20130101) Original (OR) Class E01D 19/048 (20130101) E01D 19/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333074 | Merems et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul A. Merems (Tucson, Arizona); Shane Olsen (Tucson, Arizona) |
| ABSTRACT | A nose or tail assembly for a flight vehicle is provided in which the deployment of the canards or fins is driven by energy imparted by the shroud when it is released. A tip section is rotatably coupled to a base, and both are stowed in a volume between the shroud and nose/tail assembly. As the shroud is released, a drive feature engages the tip section to rotate and join the base to form a complete canard or fin. This eliminates the need for storing the canards or fins in or wrapped around the body and eliminates the need for a complex deployment mechanism occupying an internal volume of the body. Although viable for all sizes of flight vehicles, the shroud-driven deployment system scales to very small diameter vehicles in which internal volume is not available to store either flight surfaces or deployment mechanisms. |
| FILED | Tuesday, April 28, 2020 |
| APPL NO | 16/860530 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 10/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333089 | HAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Ming HAN (Okemos, Michigan) |
| ABSTRACT | A system and method for demodulation of a fiber optic interferometric sensor are provided. Another aspect pertains to a system and method employing a single laser to generate multiple quadratic wavelengths to demodulate fiber optic interferometric sensors with approximately sinusoidal fringes. Yet another aspect of the present system and method uses a single frequency laser which is split into multiple paths using a fiber optic coupler, with one path including an intensity modulator and another path including an acousto-optic modulator, whereafter the paths are recombined into a fiber which leads to an interferometric sensor, and the light reflected from the sensor is then directed to a photodetector. A further aspect employs a single frequency laser which is split into multiple paths, with the light in the paths being modulated at different frequencies, whereafter the paths are recombined into a fiber which leads to an interferometric sensor. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237438 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02003 (20130101) G01B 9/02028 (20130101) Original (OR) Class G01B 2290/70 (20130101) Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/35316 (20130101) Optical Elements, Systems, or Apparatus G02B 6/29347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333106 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | Jianfeng Wu (Tucson, Arizona); Matthew Wade Puckett (Phoenix, Arizona); Karl D. Nelson (Plymouth, Minnesota) |
| ABSTRACT | A method for reducing or eliminating bias instability in a SBS laser gyroscope comprises introducing a first pump signal propagating in a CW direction, and a second pump signal propagating in a CCW direction in a resonator; generating a CCW first-order SBS signal and a CW first-order SBS signal in the resonator; increasing a power level of the first pump signal above a threshold level such that the CW first-order SBS signal generates a CCW second-order SBS signal; and increasing a power level of the second pump signal above the threshold level such that the CCW first-order SBS signal generates a CW second-order SBS signal. Above the threshold level, an intensity fluctuation of the first-order SBS signals disappear and their DC power are clamped at substantially the same power level. A Kerr effect bias instability of the SBS laser gyroscope is reduced or eliminated by the clamped first-order SBS signals. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 16/858272 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/661 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/302 (20130101) H01S 3/0675 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333206 | Millard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAYTHEON COMPANY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Millard (Sahuarita, Arizona); John O. Crawford (Vail, Arizona) |
| ABSTRACT | A transmissometer and method for determining a transmissivity of an atmosphere within a chamber. A chamber contains the atmosphere. A light source generates a test beam and a light detector detects the test beam. A periscope is movable between a first position which allows the test beam to pass through the atmosphere in the chamber and into the light detector and a second position in which the test beam is deflected to pass into the light detector without passing through the atmosphere in the chamber. A processor determines the transmissivity of the atmosphere from a transmissivity measurement for the test beam obtained by the light detector when the periscope is in the first position and a transfer standard obtained at the light detector when the periscope is in the second position. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 16/856370 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/59 (20130101) Original (OR) Class G01N 2201/12769 (20130101) Optical Elements, Systems, or Apparatus G02B 23/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333356 | Robinson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Robinson (Kettering, Ohio) |
| ABSTRACT | A radar system includes a beamformer that uses space-time adaptive processing using random matrix theory. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236441 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/292 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333359 | Grigsby et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Will R. Grigsby (Austin, Texas); Joseph S. McGaughey (Austin, Texas); Eric A. Rundquist (Bedford, New Hampshire) |
| ABSTRACT | The present disclosure is a system comprising at least three electronically steered antennas arranged so that there is a baseline difference of a predetermined amount of wavelength between the centers of the antennas, typically configured as an obtuse or scalene triangle, where the distance between each antenna on an array is selected to provide the required accuracy and precision, the array having a timing circuit to ensure that the beam of each antenna is steered to the same azimuthal and elevation coordinates in space simultaneously. This enables the three electronically steered antennas to operate as an interferometer to determine a bearing to a target to ultimately determine the location thereof. The electronically steered antennas enable the system to be mounted on a platform in a small package that was previously difficult for traditional interferometers. |
| FILED | Tuesday, April 28, 2020 |
| APPL NO | 16/860492 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/414 (20130101) Original (OR) Class G01S 13/885 (20130101) Antennas, i.e Radio Aerials H01Q 15/10 (20130101) H01Q 15/0086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333443 | Gopinath et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juliet T. Gopinath (Boulder, Colorado); Victor M. Bright (Boulder, Colorado); Mo Zohrabi (Boulder, Colorado); Robert H. Cormack (Erie, Colorado) |
| ABSTRACT | Wide-angle beam steering using two or more variable lenses to form a small-angle beam steering element, along with a numerical aperture converter and a wide-angle lens. The small-angle beam steering element might comprise either one- or two-dimensional beam steering with tunable liquid lenses. |
| FILED | Tuesday, August 15, 2017 |
| APPL NO | 16/326159 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 3/12 (20130101) Original (OR) Class G02B 26/005 (20130101) G02B 26/101 (20130101) G02B 26/0875 (20130101) G02B 2207/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333575 | Hu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Juejun Hu (Newton, Massachusetts); Tian GU (Fairfax, Virginia); Yifei ZHANG (Cambridge, Massachusetts); Carlos Andres Rios Ocampo (Somerville, Massachusetts); Mikhail Shalaginov (Somerville, Massachusetts); Xiaoming Qiu (Somerville, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Juejun Hu (Newton, Massachusetts); Tian GU (Fairfax, Virginia); Yifei ZHANG (Cambridge, Massachusetts); Carlos Andres Rios Ocampo (Somerville, Massachusetts); Mikhail Shalaginov (Somerville, Massachusetts); Xiaoming Qiu (Somerville, Massachusetts) |
| ABSTRACT | Reversible phase-change materials (PCMs) can be added to or incorporated into meta-lenses, wave plates, waveguides, gratings, and other optical components to form active optical devices with controllable and adjustable optical characteristics. Local heating can be used to induce solid-state phase changes and large refractive index changes in the PCMs. The phase and index changes can provide large changes in the device's optical characteristics. Optical devices with PCM can be used for imaging applications, orbital angular momentum control, photonic integrated circuits and optical communication systems, beam steering, and other application. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/183267 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0147 (20130101) Original (OR) Class G02F 2202/30 (20130101) G02F 2203/69 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333711 | Eden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Gary Eden (Champaign, Illinois); Dane Sievers (Fisher, Illinois); Andrey Mironov (Urbana, Illinois); Jinhong Kim (Champaign, Illinois) |
| ABSTRACT | A fabrication tool has at least one flat lamp photon source, or an array of flat lamps, that serve to non-thermally ablate polymer material from a surface. No photoresist is required and the desired photoablated pattern is determined by inserting a photolithographic mask between the lamp(s) and the surface to be processed. Methods of the invention pattern organic polymer and can pattern a substrate using a pattern established in an organic polymer layer on the substrate, and can also deposit materials in the pattern by breaking bonds in deposition precursors with photons from the microplasma array. Another method converts organic polymer material to have a hydrophylic surface. A tool of the invention can have width and depth comparable to a typical paperback book and a height comparable to a coffee cup. |
| FILED | Tuesday, August 13, 2019 |
| APPL NO | 17/268276 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/039 (20130101) Original (OR) Class G03F 7/203 (20130101) G03F 7/2004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210334089 | Graham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Graham (Havre de Grace, Maryland); Raymond Steeley (Bel Air, Maryland); Eugene Thompson (Oxford, Pennsylvania); Thomas Rinaldi (Aberdeen Proving Ground, Maryland); Christopher Myers (West Grove, Pennsylvania) |
| ABSTRACT | Various embodiments that pertain to device software is described. A decision can be made by a device on if the device should download an update for device software, such as a software patch. When the device decides that it should download the update, the device can download the appropriate update. In one example, the update can be downloaded by way of a patch portal that communicates with a patch database. The device can request the patch for the software and in response the device can be provided access to the patch by way of the patch portal. |
| FILED | Tuesday, April 28, 2020 |
| APPL NO | 16/860445 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/658 (20180201) Original (OR) Class G06F 21/30 (20130101) G06F 21/57 (20130101) Computer Systems Based on Specific Computational Models G06N 5/025 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 47/805 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210334685 | Anahid et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Masoud Anahid (Simsbury, Connecticut); Tahany Ibrahim El-Wardany (Vernon, Connecticut); Sergei F. Burlatsky (West Hartford, Connecticut); William K. Tredway (Manchester, Connecticut) |
| ABSTRACT | A method of evaluating an additive manufacturing process includes receiving a set of additive manufacturing parameters and an additive manufacturing part design at an analysis module, receiving a set of random values at the analysis module, determining a probability distribution of stochastic flaws within a resultant additively manufactured article using at least one multidimensional space physics model, and categorizing the additive manufacturing part design as defect free when the probability distribution is below a predefined threshold. Each value in the set of random values corresponds to a distinct variable in a set of variables. Each variable in the set of variables at least partially defines at least one of an uncontrolled additive manufacturing parameter and an uncontrollable additive manufacturing parameter. |
| FILED | Monday, April 27, 2020 |
| APPL NO | 16/859349 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4099 (20130101) G05B 2219/49023 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210334703 | Salamat et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sahand Salamat (San Diego, California); Mohsen Imani (San Diego, California); Behnam Khaleghi (San Diego, California); Tajana Rosing (San Diego, California) |
| ABSTRACT | A method of defining an implementation of circuits in a programmable device can be provided by receiving a plurality of specifications for a hyperdimensional (HD) computing machine learning application for execution on a programmable device, determining parameters for a template architecture for HD computing machine learning using the plurality of specifications, the template architecture including an HD hypervector encoder, an HD associative search unit, programmable device pre-defined processing units, and programmable device pre-defined processing elements within the pre-defined processing units, and generating programmable device code configured to specify resources to be allocated within the programmable device using pre-defined circuits defined for use in the programmable device using the determined parameters for the template architecture. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236640 |
| CURRENT CPC | Electric Digital Data Processing G06F 15/80 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210334908 | Shu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kai SHU (Mesa, Arizona); Deepak MANUDESWARAN (Tempe, Arizona); Huan LIU (Tempe, Arizona); Arizona Board of Regents of Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Shu (Mesa, Arizona); Deepak Manudeswaran (Tempe, Arizona); Huan Liu (Tempe, Arizona) |
| ABSTRACT | Detecting fake news involves receiving a plurality of allegedly real news stories and allegedly fake news stories from one or more websites, receiving a plurality of user posts to a social media platform relating to the plurality of allegedly real news stories and allegedly fake news stories; receiving a plurality of user engagements related to the plurality of user posts, receiving user profile information, and social media network information, for users creating the plurality of user posts to the social media platform, and users participating in the engagements related to the plurality of user posts, and classifying each of the received plurality of allegedly real news stories and allegedly fake news stories as one of a real news story and a fake news story based on the analyzed content and analyzed social media context. |
| FILED | Monday, September 23, 2019 |
| APPL NO | 17/267765 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0201 (20130101) G06Q 50/01 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210335452 | Beal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Stuart Michael Beal (Iowa City, Iowa); Thomas Cushing Mitchell (Boston, Massachusetts); Daniel Wyschogrod (Newton, Massachusetts) |
| ABSTRACT | According to an example, a method of analyzing an output of a sequencer is provided comprising identifying genetic targets, obtaining target signature snippets responsive thereto, each target signature snippet derived from a genetic sequence of the genetic targets, receiving portions of a test sequence output by a sequencer sequencing a sample in real time, determining, in real time or near-real time with the sequencer sequencing the sample, whether a target signature snippet of the target signature snippets is in at least one portion of the test sequence, determining, for each genetic target, a probability the genetic target is in the sample based on the determination of whether the target signature snippet is present in the at least one portion of the test sequence, and outputting an analysis of the sample indicating the respective probability that each genetic target is present in the sample. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181865 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) Original (OR) Class G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210335454 | Beal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Stuart Michael Beal (Iowa City, Iowa); Thomas Cushing Mitchell (Boston, Massachusetts); Daniel Wyschogrod (Newton, Massachusetts); Allison Jordan Taggart (Portsmouth, Rhode Island) |
| ABSTRACT | According to at least one example, a method of filtering signature snippets is provided comprising identifying a group of genetic targets, obtaining a plurality of sets of one or more target signature snippets responsive to identifying the group of genetic targets, each set of one or more target signature snippets corresponding to a respective genetic target of the group of genetic targets and being derived from a genetic sequence of the respective genetic target, filtering the plurality of sets of one or more target signature snippets to identify a set of one or more universal target signature snippets, and outputting the set of one or more universal target signature snippets. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181858 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) G16B 40/00 (20190201) Original (OR) Class G16B 45/00 (20190201) G16B 50/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210335591 | KIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina); Coldquanta, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jungsang KIM (Chapel Hill, North Carolina); Geert VRIJSEN (Durham, North Carolina); Ismail INLEK (Durham, North Carolina); Tom NOEL (Boulder, Colorado); Megan IVORY (Boulder, Colorado); Alexander KATO (Boulder, Colorado); Steve HUGHES (Boulder, Colorado) |
| ABSTRACT | Aspects of the present disclosure describe systems, methods, and structures that enable a compact, UHV ion trap system that can operate at temperatures above cryogenic temperatures. Ion trap systems in accordance with the present disclosure are surface treated and sealed while held in a UHV environment, where disparate components are joined via UHV seals, such as weld joints, compressible metal flanges, and UHV-compatible solder joints. As a result, no cryogenic pump is required, thereby enabling an extremely small-volume system. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/371899 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Electric Discharge Tubes or Discharge Lamps H01J 49/16 (20130101) H01J 49/24 (20130101) H01J 49/42 (20130101) H01J 49/422 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210337357 | KASSAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zak KASSAS (Irvine, California); Kimia SHAMAEI (Irvine, California) |
| ABSTRACT | Processes and device configurations, including a receiver structure, are provided to jointly estimate the time-of-arrival (TOA) and azimuth and elevation angles of direction-of-arrival (DOA) from signals of opportunity, such as received cellular long-term evolution (LTE) signals. In one embodiment, a matrix pencil (MP) algorithm is used to obtain a coarse estimate of the TOA and DOA. Tracking loop configurations are provided to refine the estimates and jointly track the TOA and DOA changes. One or more solutions are provided for acquisition and tracking in the presence of noise and multipath signals. Processes and devices configurations are provided to use refined estimates to determine position and for use in navigation of a device. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237290 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0205 (20130101) Wireless Communication Networks H04W 4/029 (20180201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210330809 | Negrete et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oscar Negrete (Livermore, California); C. Jeffrey Brinker (Albuquerque, New Mexico); Torri Rinker (Kennewick, Washington); Annette Estelle LaBauve (Hayward, California) |
| ABSTRACT | The present invention relates to lipid-coated particles for treating viral infections, including viral encephalitis infections. In particular, an antiviral compound can be disposed within the lipid-coated particle, thereby providing an antiviral carrier. Methods of making and using such carriers are described herein. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306452 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 31/4965 (20130101) A61K 47/543 (20170801) A61K 47/6913 (20170801) A61K 47/6915 (20170801) Original (OR) Class A61K 47/6917 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210331270 — Joining Method to Perform Defect-Free, Electron Beam Welds Using a Slope-Out Technique
| US 20210331270 | Dutilleul |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas Dutilleul (Wattrelos, France) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Dutilleul (Wattrelos, France) |
| ABSTRACT | The present invention provides a modification to the EBW process, which is referred to as a slope-out methodology, the results in the formation of a “slope-out portion” located generally in that region of the overall weldment located at the end of the ordinary EBW welding process for joining two components. The slope-out portion overlaps with the initial weld of the workpiece for a given distance or length along the weld and effectively eliminates the keyhole and provides a weldment that has minimal to no defects, particularly in the slope-out portion. The slope-out methodology begins by adjusting various parameters related to the electron beam to essentially decay the beam. In general, the focus position of the electron beam is moved from under-focused (focal position in the bulk of the material) to over-focused (focal position ahead of the workpiece surface) as the overlapping weld is made. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/191293 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 15/0013 (20130101) B23K 15/0053 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332350 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (, None) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Christopher J. Gregg (Roslindale, Massachusetts); Marc J. Lajoie (Cambridge, Massachusetts); Xavier Rios Villanueva (Boston, Massachusetts) |
| ABSTRACT | A method of altering a target nucleic acid sequence within a cell is provided including providing the cell with a donor nucleic acid, providing the cell with a single strand annealing protein, and providing the cell with a single strand DNA binding protein, wherein one or more or both of the single strand annealing protein and the single strand DNA binding protein is foreign to the cell, and wherein the donor nucleic acid is recombined into the target nucleic acid. |
| FILED | Thursday, February 02, 2017 |
| APPL NO | 16/075281 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332376 | Ambavaram et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YIELD10 BIOSCIENCE, INC. (Woburn, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Madana M.R. Ambavaram (Norwood, Massachusetts); Mariya Somleva (Cambridge, Massachusetts) |
| ABSTRACT | Methods comprising DNA constructs and polynucleotides of functional transcription factors for improving photosynthetic capacity, biomass and/or grain yield and stress tolerance in various crop and model plants, dicots and monocots with the C3 or C4 photosynthetic pathways are described herein. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/210962 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8241 (20130101) C12N 15/8245 (20130101) C12N 15/8251 (20130101) C12N 15/8261 (20130101) Original (OR) Class C12N 15/8271 (20130101) C12N 15/8273 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332392 | Park et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan Mcfarland Park (Dublin, California); Ziye Dong (Dublin, California); Yongqin Jiao (Pleasanton, California) |
| ABSTRACT | This disclosure provides microbes for the preferential separation of Scandium (Sc) from rare earth element (REE) containing materials, as well as methods of use thereof. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240794 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 3/00 (20130101) Original (OR) Class Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/18 (20130101) C22B 61/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332398 | Eng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas T. Eng (Berkeley, California); Deepanwita Banerjee (Emeryville, California); Aindrila Mukhopadhyay (Oakland, California) |
| ABSTRACT | The present invention provides for a genetically modified bacterial host cell capable of producing indigoidine, wherein the host cell comprises a non-ribosomal peptide synthetase (NRPS) that converts glutamine to indigoidine, and the bacterial host cell is reduced in its expression of one or more of the sixteen indicated enzymes. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180633 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) C12N 15/70 (20130101) C12N 15/78 (20130101) C12N 2310/20 (20170501) C12N 2510/02 (20130101) C12N 2511/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/165 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332428 | Church et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George M. Church (Brookline, Massachusetts); Liangcai Gu (Boston, Massachusetts) |
| ABSTRACT | Methods for attaching barcodes to polypeptides are provided. Methods for detecting molecular interactions at the single molecule level are provided. Embodiments of the invention are directed to a ONA barcoded protein array technology for parallel protein interaction profiling on a single molecule basis. DNA barcodes are attached to proteins collectively via ribosome display or individually via enzymatic conjugation. Novel methods are described herein that measure protein interactions based on the statistical analysis of co-localized polonies arising from barcoding DNAs of interacting proteins. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361508 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6809 (20130101) C12Q 1/6853 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332530 | Magurudeniya et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY AND ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harsha D. Magurudeniya (Newport News, Virginia); Alberto Rodriguez (Oakland, California); Nawa Raj Baral (Hayward, California); Blake A. Simmons (San Francisco, California); John M. Gladden (Alameda, California) |
| ABSTRACT | The present invention provides for a method to deconstruct a biomass: the method comprising: (a) ensiling a biomass to produce comprising one or more organic acids, and (b) introducing a solvent to the ensiled biomass to dissolve at least part of solid biomass in the solvent, wherein the solvent is an ionic liquid (IL) or deep eutectic solvent (DES), or mixture thereof, to form a solubilized biomass mixture. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/242256 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/40 (20210501) Production of Cellulose by Removing Non-cellulose Substances From Cellulose-containing Materials; Regeneration of Pulping Liquors; Apparatus Therefor D21C 3/20 (20130101) Original (OR) Class D21C 11/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332651 | Jew |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Jew (Mountain View, California) |
| ABSTRACT | An acid spearhead formulation for mineral scale reduction that includes a sulfuric acid solution having an acidity that is substantially equivalent to a hydrochloric acid solution in an acid spearhead formulation, a sodium citrate compound, where an acid spearhead formulation for mineral scale reduction is formed, the acid spearhead formulation is disposed in a well bore to stabilize mineral scales, the acid spearhead formulation is disposed in the well bore to chelate solubilized calcium in a rock bed of the well bore, and the well bore includes a temporal thermodynamic subsurface barite cycling having a subsurface barite dissolution temporal phase, a subsurface barite transport to fractures temporal phase, a subsurface barite precipitation to fracture temporal phase and a subsurface barite dissolution to fracture space temporal phase, where the acid spearhead formulation for mineral scale reduction reacts with the well bore within the subsurface barite dissolution temporal phase. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/371757 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/02 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 21/068 (20130101) Original (OR) Class E21B 43/26 (20130101) E21B 43/162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332705 | Martin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas J. Martin (East Hampton, Connecticut); John E. Holowczak (South Windsor, Connecticut); Matthew B. Kennedy (Vernon, Connecticut); Paul F. Croteau (Columbia, Connecticut); Paul Attridge (Colchester, Connecticut) |
| ABSTRACT | An airfoil includes an airfoil section that has an airfoil wall that surrounds a cavity. The airfoil wall includes an exterior monolithic ceramic shell and an interior CMC liner that has CMC plies. An outermost ply of the CMC plies forms tabs that are raised from an underlying ply so as to define a slot. The exterior monolithic ceramic shell includes an underlapping shell piece and an overlapping shell piece. The underlapping shell piece has a portion disposed in the slot and bonded with the tabs. The overlapping shell piece extends over the tabs and is bonded to the tabs. There are channels bounded by adjacent ones of the tabs, the underlapping shell piece, and the overlapping shell piece. Channel orifices through the CMC liner connect the cavity and the channels. |
| FILED | Monday, April 27, 2020 |
| APPL NO | 16/859198 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/147 (20130101) Original (OR) Class F01D 5/282 (20130101) F01D 5/284 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2300/6033 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333423 | Raghukumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Integral Consulting Inc. (Seattle, Washington) |
| ASSIGNEE(S) | Integral Consulting Inc. (Seattle, Washington) |
| INVENTOR(S) | Kaustubha Raghukumar (Santa Cruz, California); Grace Chang Spada (Santa Barbara, California); Frank Spada (Santa Barbara, California); Craig A. Jones (Santa Cruz, California) |
| ABSTRACT | An acoustic monitoring system characterizes, classifies, and geo-locates anthropogenic and natural sounds in near real time. The system includes a compact array of three acoustic vector sensors, which measures acoustic pressure and the three-dimensional particle velocity vector associated with the propagation of an acoustic wave, thereby inherently providing bearing information to an underwater source of sound. Beamforming techniques provide sound source localization, allowing for characterization of the acoustic signature of specific underwater acoustic sources. |
| FILED | Wednesday, May 20, 2020 |
| APPL NO | 16/879434 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 17/00 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 1/16 (20130101) Original (OR) Class Transmission H04B 11/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333431 | Kroc et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas K. Kroc (Batavia, Illinois); Robert Kephart (Pioneer, California) |
| ABSTRACT | A system, method, and apparatus for wellbore inspection comprise an electron accelerator to generate X-rays, a rotating collimator assembly configured to produce a cone of X-rays, and at least one detector assembly configured to collect backscattered X-rays. A position assembly can be provided to move the electron accelerator, rotating collimator assembly, and detector through a wellbore. A computer system is configured to receive data from the detector and generate an image of the wellbore. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/342525 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/046 (20130101) G01N 23/203 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/12 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 27/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210334098 | Scrbak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marko Scrbak (Austin, Texas); Mahzabeen Islam (Austin, Texas); John Kalamatianos (Arlington, Massachusetts); Jagadish B. Kotra (Austin, Texas) |
| ABSTRACT | A processor includes a micro-operation cache having a plurality of micro-operation cache entries for storing micro-operations decoded from instruction groups and a micro-operation filter having a plurality of micro-operation filter table entries for storing identifiers of instruction groups for which the micro-operations are predicted dead on fill if stored in the micro-operation cache. The micro-operation filter receives an identifier for an instruction group. The micro-operation filter then prevents a copy of the micro-operations from the first instruction group from being stored in the micro-operation cache when a micro-operation filter table entry includes an identifier that matches the first identifier. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 16/856832 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/264 (20130101) Original (OR) Class G06F 9/3887 (20130101) G06F 12/0893 (20130101) G06F 16/9017 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210334952 | Kalluri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Udaya C. Kalluri (Knoxville, Tennessee); Andrzej Nycz (Knoxville, Tennessee); Lonnie J. Love (Knoxville, Tennessee); Vincent C. Paquit (Knoxville, Tennessee); Xiaohan Yang (Knoxville, Tennessee); Samuel C. Leach (Knoxville, Tennessee); Harold Walters (Knoxville, Tennessee) |
| ABSTRACT | A method and a system for automated plant surveillance and manipulation are provided. Pursuant to the method and the system, images of target plants are obtained through a machine vision system having multiple cameras. The obtained images of the target plants are processed to determine tissue candidates of the target plants and to determine a position and an orientation of each tissue candidate. A tool is manipulated, based on the position and the orientation of each tissue candidate, to excise each tissue candidate to obtain tissue samples. The tissue samples are transported for subsequently manipulation including live processing of the tissue samples or destructive processing of the tissue samples. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237503 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1697 (20130101) Image Data Processing or Generation, in General G06T 7/0004 (20130101) Original (OR) Class G06T 2207/30188 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210335509 | Barger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT mPower, Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Earl Brian Barger (Goode, Virginia); Scott L. Fitzner (Appomattox, Virginia); Jeffrey T. Lee (Blacksburg, Virginia); Roger D. Ridgeway (Lynchburg, Virginia) |
| ABSTRACT | A fuel rod for a nuclear reactor, including a cladding tube having a first end with an annular end face, a second end with an annular end face, and a cylindrical body portion extending therebetween, and a first tube end plug including a front portion, an annular lip with an annular end face, and a substantially straight cylindrical body portion extending therebetween, wherein the surface area of the annular end face of the first end of the cladding tube and the annular end face of the annular lip of the first tube end plug are substantially equal, and the annular end face of the first end of the cladding tube and the annular end face of the annular lip of the first tube end plug are connected by a resistance pressure weld. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332046 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 11/002 (20130101) B23K 11/093 (20130101) B23K 33/006 (20130101) B23K 2101/06 (20180801) Nuclear Reactors G21C 3/10 (20130101) Original (OR) Class G21C 21/02 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 30/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210335866 | Hall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Lawrence Hall (San Ramon, California); Mihail Bora (Livermore, California); Adam Conway (Livermore, California); Philip Datte (Concord, California); Qinghui Shao (Fremont, California); Erik Lars Swanberg, JR. (Livermore, California); Clement Antoine Trosseille (San Ramon, California); Charles Edward Hunt (Davis, California) |
| ABSTRACT | Devices, systems and methods for solid-state X-ray detection with high temporal resolution are described. An example method includes receiving an X-ray pulse in a semiconductor chip resulting in an electron cloud being formed in the semiconductor chip, applying a first set of voltages across a first plurality of drift cathode strips on a first side of the semiconductor chip and a second plurality of drift cathode strips on a second side of the semiconductor chip, applying a second set of voltages to across the first and the second plurality of drift cathode strips to form an electric field having a linear profile to cause the electron cloud to drift along the middle of the semiconductor chip, and activating a counter cathode on the second side and one or more readout anodes on the first side to collect the electron cloud after spreading in the middle section of the semiconductor chip. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/241594 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/083 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 22/12 (20130101) H01L 27/14603 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210336131 | Voss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lars F. Voss (Livermore, California); Adam M. Conway (Livermore, California); John E. Heebner (Livermore, California) |
| ABSTRACT | A high-voltage switch, whose operation leverages the speed of electrons to generate the “on” time of the pulse in combination with the speed of light to generate the “off” time of the pulse, is described. In one example, the high-voltage switch includes a first electrode, a second electrode spaced apart from the first electrode, a region of non-absorbing material occupying a portion of the space between the first and second electrodes and allowing a laser pulse to propagate therethrough without substantial absorption, and a region of absorbing material occupying another portion of the space and producing a charged particle cloud upon receiving the laser pulse. The high-voltage switch remains “on” upon the charged particle cloud reaching an electrode and until it has been collected by the electrode, and where the high-voltage switch remains “off” subsequent to the collection and until another generated charged particle cloud reaches the electrode. |
| FILED | Wednesday, December 19, 2018 |
| APPL NO | 17/271428 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 45/00 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/0428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210336240 — MODIFICATION OF LITHIUM ION ELECTRODE MATERIALS VIA ATOMIC LAYER DEPOSITION TECHNIQUES
| US 20210336240 | Mane et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Anil U. Mane (Naperville, Illinois); Jason R. Croy (Plainfield, Illinois); Jeffrey W. Elam (Elmhurst, Illinois); Arturo Gutierrez (Naperville, Illinois); Jihyeon Gim (Naperville, Illinois); Devika Choudhury (Naperville, Illinois); Eungje Lee (Naperville, Illinois); Hakim Iddir (Elmhurst, Illinois) |
| ABSTRACT | A method for coating of lithium ion electrode materials via atomic layer deposition. The coated materials may be integrated in part as a dopant in the electrode itself via heat treatment forming a doped lithium electrode. |
| FILED | Wednesday, April 22, 2020 |
| APPL NO | 16/855676 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/45555 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) H01M 4/0428 (20130101) Original (OR) Class H01M 4/483 (20130101) H01M 4/525 (20130101) H01M 10/0525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210336251 | Venkatachalam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zenlabs Energy, Inc. (Fremont, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Subramanian Venkatachalam (Pleasonton, California); Sanjeev Sharma (Fremont, California); Xianyu Iris Li (Mountain View, California); Pedro A. Hernandez-Gallegos (Pleasonton, California); Charan Masarapu (Fremont, California); Sujeet Kumar (Newark, California); Herman A. Lopez (Sunnyvale, California) |
| ABSTRACT | Improved negative electrodes can comprise a silicon based active material blended with graphite to provide more stable cycling at high energy densities. In some embodiments, the negative electrodes comprise a blend of polyimide binder mixed with a more elastic polymer binder with a nanoscale carbon conductive additive. The silicon-based blended graphite negative electrodes can be matched with positive electrodes comprising nickel rich lithium nickel manganese cobalt oxides to form high energy density cells with good cycling properties. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370678 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/483 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/587 (20130101) H01M 4/622 (20130101) H01M 4/623 (20130101) H01M 4/625 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210336291 | Nanda et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jagjit Nanda (Knoxville, Tennessee); Ethan C. Self (Knoxville, Tennessee); Frank M. Delnick (Maryville, Tennessee) |
| ABSTRACT | A solid electrolyte (SE) composition comprising a homogeneous blend of lithium thiophosphate particles and a polyalkylene oxide, wherein the lithium thiophosphate particles have the formula xLi2S.(1−x)P2S5 wherein x is a value within a range of 0.5-0.9, and wherein said polyalkylene oxide is present in an amount of 0.1-10 wt % of the solid electrolyte. Also described herein is a solid-state lithium-based battery comprising: a) an anode; (b) a cathode; and c) the SE composition described above. Further described herein is a method for producing the SE composition, comprising: (i) homogeneously mixing Li2S, P2S5, a polyalkylene oxide, and a solvent to form a liquid solution or liquid homogeneous dispersion, and (ii) heating the liquid solution or liquid homogeneous dispersion produced in step (i) to remove the solvent and produce the SE composition. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236347 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 25/30 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/02 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210337219 | TOHLEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | MICHAEL AARON TOHLEN (LEE'S SUMMIT, Missouri); MITCHELL HEDGES MORROW (OVERLAND PARK, Kansas); JOSHUA J. MILLER (KANSAS CITY, Missouri) |
| ABSTRACT | A computer-implemented method for compressing video data comprises receiving a sequence of video data values, each video data value being a digital value from a successive one of a plurality of pixels that form a video sensor, the sequence of video data values resulting from successive frames of video captured by the video sensor; extracting the video data values for each pixel in turn to create a plurality of pixel data streams, each pixel data stream including the video data value for each frame of captured video for the pixel; and applying data compression to each pixel data stream to create compressed data for each pixel data stream. |
| FILED | Monday, February 15, 2021 |
| APPL NO | 17/175919 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 19/132 (20141101) H04N 19/136 (20141101) H04N 19/172 (20141101) H04N 19/182 (20141101) H04N 19/184 (20141101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210337286 | McDonald et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas McDonald (Fort Collins, Colorado); Gary Gostin (Plano, Texas); Alan Davis (Palo Alto, California) |
| ABSTRACT | A system for hot swapping a network switch without disconnecting the network switch connectors is provided. The system disaggregates the switch faceplate network cable connectors from the internal components of the network switch so that the internal switch components may be removed from the switch without disconnecting the switch network cables. |
| FILED | Friday, April 27, 2018 |
| APPL NO | 17/048850 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 49/15 (20130101) H04L 49/30 (20130101) H04L 49/45 (20130101) Selecting H04Q 11/0005 (20130101) Original (OR) Class H04Q 2011/0041 (20130101) H04Q 2011/0052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210330328 | Dreilinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NeuraMedica Inc. (Oregon City, Oregon) |
| ASSIGNEE(S) | NeuraMedica Inc. (Oregon City, Oregon) |
| INVENTOR(S) | Rachel Dreilinger (Beavercreek, Oregon); Neil Roundy (Eugene, Oregon); Mariah Knight (Cornelius, Oregon); Sandra Baker (Tigard, Oregon) |
| ABSTRACT | A medical device forming method, an applier for manipulating clips, and a cartridge for holding clips are disclosed herein. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 16/858546 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/083 (20130101) Original (OR) Class A61B 17/1222 (20130101) A61B 2017/0488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330599 | BENOIT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Danielle BENOIT (Rochester, New York); Hyun KOO (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods to treat and/or prevent biofilms and biofilm related diseases. The invention comprises a nanoparticle carrier (NPC) and at least one therapeutic agent therein. The NPC binds within biofilm and to surfaces at risk for biofilm formation and accumulation while providing local, sustained, enhanced and controlled delivery of the therapeutic agent, when triggered for release. In one embodiment, the NPC comprises pH-responsive elements that allows for specific delivery of the therapeutic agent when the local environment dictates that the agent should be delivered precisely when it is most needed. |
| FILED | Tuesday, August 01, 2017 |
| APPL NO | 16/322636 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/5026 (20130101) A61K 9/5138 (20130101) Original (OR) Class A61K 31/045 (20130101) A61K 31/155 (20130101) A61K 31/352 (20130101) A61K 31/353 (20130101) A61K 31/505 (20130101) A61K 33/16 (20130101) A61K 33/18 (20130101) A61K 33/22 (20130101) A61K 38/47 (20130101) A61K 38/443 (20130101) A61K 45/06 (20130101) A61K 47/6925 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/02 (20180101) A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210331121 | Mitra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Somenath Mitra (Bridgewater, New Jersey); Sagar Roy (Newark, New Jersey); Oindrila Gupta (Harrison, New Jersey) |
| ABSTRACT | A membrane distillation (MD) system includes a membrane module and reduced graphene oxide-carbon nanotube immobilized membrane for organic solvent separation. The MD module could include a feed inlet and outlet, a sweep gas inlet, and a sweep gas outlet. Thermostats are positioned at the feed inlet and outlet to measure the change in temperature. Preferential sorption of the organic, specifically tetrahydrofuran (THF), on a hybrid reduced graphene oxide-carbon nanotube immobilized membrane contributes to enhanced solvent removal of the MD system. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225424 |
| CURRENT CPC | Separation B01D 61/364 (20130101) B01D 61/366 (20130101) B01D 69/141 (20130101) Original (OR) Class B01D 71/021 (20130101) B01D 71/024 (20130101) B01D 2311/13 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/445 (20130101) C02F 2101/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210331249 | Kar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aravinda Kar (Orlando, Florida); Ranganathan Kumar (Orlando, Florida); Eduardo Castillo Orozco (Orlando, Florida) |
| ABSTRACT | A laser-assisted microfluidics manufacturing process has been developed for the fabrication of additively manufactured structures. Roll-to-roll manufacturing is enhanced by the use of a laser-assisted electrospray printhead positioned above the flexible substrate. The laser electrospray printhead sprays microdroplets containing nanoparticles onto the substrate to form both thin-film and structural layers. As the substrate moves, the nanoparticles are sintered using a laser beam directed by the laser electrospray printhead onto the substrate. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/366442 |
| CURRENT CPC | Spraying Apparatus; Atomising Apparatus; Nozzles B05B 5/025 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/04 (20130101) B05D 3/06 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0018 (20130101) B22F 10/10 (20210101) B22F 12/00 (20210101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/00 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) Manufacture, Shaping, or Supplementary Processes C03B 19/01 (20130101) C03B 19/06 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/06 (20130101) H01L 31/075 (20130101) H01L 31/0312 (20130101) H01L 31/0745 (20130101) H01L 31/1812 (20130101) H01L 31/035218 (20130101) H01L 31/035254 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210331927 | TIAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Arkansas (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Z.R. TIAN (Fayetteville, Arkansas); Hulusi TURGOT (Fayetteville, Arkansas) |
| ABSTRACT | In one aspect, graphene oxide compositions are described herein. Briefly, a graphene oxide composition comprises sheets of graphene oxide cross-linked with one another via metal cations in an oxidation state of at least 3+. As described further herein, faces and/or edges of the graphene oxide sheets can be cross-linked by the metal cations. In some embodiments, metal cations are covalently bonded to faces and/or edges of the graphene oxide sheets. |
| FILED | Thursday, August 03, 2017 |
| APPL NO | 16/322849 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/198 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/20 (20130101) C01P 2004/64 (20130101) C01P 2006/82 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332338 | Jantz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | Derek Jantz (Durham, North Carolina); Michael G. Nicholson (Chapel Hill, North Carolina); James Jefferson Smith (Morrisville, North Carolina) |
| ABSTRACT | Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional effectors can comprise (i) a meganuclease DNA-binding domain lacking endonuclease cleavage activity that binds to a target recognition site; and (ii) a transcription effector domain. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/224054 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 14/4702 (20130101) C07K 14/4703 (20130101) C07K 2319/09 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332346 | KAAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate (Denver, Colorado); THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joel L. KAAR (Lafayette, Colorado); Garrett CHADO (San Francisco, California); Mark STOYKOVICH (Chicago, Illinois) |
| ABSTRACT | The invention provides methods and systems by which enzymes can be modified to improve solubility, catalytic activity, recoverability, and recyclability. The enzyme may be modified with a thermosensitive copolymer to form an enzyme-polymer conjugate that exhibits upper critical solution temperature (UCST) and/or lower critical solution temperature (LCST)-type behavior in an organic solvent, ionic liquid, or other solvent. Methods and systems of the invention facilitate the use of enzymes as biocatalysts in solvents. |
| FILED | Wednesday, October 09, 2019 |
| APPL NO | 17/284186 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/96 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332374 | KEASLING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jay D. KEASLING (Berkeley, California); Leo D'ESPAUX (San Francisco, California); Jeff WONG (Berkeley, California); Xiaozhou LUO (Berkeley, California); Michael REITER (Berkeley, California); Charles DENBY (Berkeley, California); Anna LECHNER (Berkeley, California) |
| ABSTRACT | The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/206126 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 63/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1085 (20130101) C12N 15/52 (20130101) C12N 15/70 (20130101) C12N 15/81 (20130101) Original (OR) Class C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Enzymes C12Y 101/01088 (20130101) C12Y 203/0301 (20130101) C12Y 203/01086 (20130101) C12Y 203/01206 (20150701) C12Y 205/01102 (20150701) C12Y 207/01036 (20130101) C12Y 207/04002 (20130101) C12Y 401/01033 (20130101) C12Y 503/03002 (20130101) C12Y 602/01003 (20130101) C12Y 604/01002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332489 | Claussen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Claussen (Ames, Iowa); Carmen L. Gomes (Ames, Iowa); Raquel Rainier Alves Soares (Ames, Iowa); Robert Hjort (Ames, Iowa); Cicero Cardoso Pola (Ames, Iowa) |
| ABSTRACT | Apparatus and methods of fabrication and use of highly effective laser-induced graphene (LIG) electrodes including for electrochemical sensing and catalysis. One example is a sensitive and label-free laser-induced graphene (LIG) electrode functionalized for a specific application. One example of functionalization with antibodies, an enzyme, or an ionophore to electrochemically quantify a target species The LIG electrodes were produced by laser induction on film having a carbon precursor (e.g. polyimide) in ambient conditions, and hence circumvent the need for high-temperature, vacuum environment, and metal seed catalysts commonly associated with graphene-based electrodes fabricated via chemical vapor deposition processes. These results demonstrate how LIG-based electrodes can be used for electrochemical sensing in general. Other examples of applications include, but are not limited to, ion-sensing, pesticide monitoring and detection, and water splitting, using the LIG-based electrode(s) adapted for those purposes. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/302229 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/184 (20170801) C01B 32/205 (20170801) C01B 2204/04 (20130101) C01B 2204/24 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2002/85 (20130101) C01P 2004/03 (20130101) C01P 2006/40 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 11/043 (20210101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333209 | YUAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BAOHONG YUAN (Arlington, Texas) |
| ABSTRACT | A method of imaging comprises disposing a population of first targeting ultrasound-switchable fluorophores and a population of second non-targeting ultrasound-switchable fluorophores in an environment; detecting a first photoluminescence signal emitted by the population of first targeting fluorophores, and a second photoluminescence signal emitted by the population of second non-targeting fluorophores; determining a photoluminescence property of the population of second non-targeting fluorophores from the second photoluminescence signal; and using the determined photoluminescence property of the population of second non-targeting fluorophores to deconvolute the first photoluminescence signal into the population of first targeting fluorophores bound and unbound to a first target binding element in the environment. |
| FILED | Tuesday, March 05, 2019 |
| APPL NO | 16/977959 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0058 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) Original (OR) Class G01N 33/542 (20130101) G01N 33/5091 (20130101) G01N 2021/6441 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333248 | Chen |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio University (Athens, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hao Chen (The Plains, Ohio) |
| ABSTRACT | A method of quantifying a target compound includes applying an oxidation/reduction potential to an electrochemical cell (14); measuring an electrochemical current during the application of the oxidation/reduction potential; and ionizing and directing the target compound before and after the application of the oxidation/reduction potential to a mass spectrometer (16) that measures a target compound ion intensity. The method further includes determining a target compound ion intensity change due to the application of the oxidation/reduction potential and determining a total amount of the target compound in the sample using the measured electrochemical current and the target compound ion intensity change. Determining the target compound ion intensity change may comprise either comparing the target compound ion intensity before and after the electrolysis relative to a reference peak or comparing the integrated peak area of a target compound ion in an extracted ion chromatogram before and after the electrolysis. |
| FILED | Wednesday, October 25, 2017 |
| APPL NO | 16/341622 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/72 (20130101) Original (OR) Class G01N 30/8679 (20130101) G01N 33/6848 (20130101) G01N 2030/8831 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333328 | Chung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ReJoule Incorporated (Signal Hill, California) |
| ASSIGNEE(S) | ReJoule incorporated (Signal Hill, California) |
| INVENTOR(S) | Steven Chung (Stanton, California); Kenny Huynh (Stanton, California); Russell Okamura (Stanton, California) |
| ABSTRACT | An electrochemical storage diagnostic system is configured to perform an electrical test to measure energy storage device parameters. The diagnostic system includes a charge management controller, electrically coupled to a power multiplexer, a power converter circuit, and an isolated converter circuit. The charge management controller is programmed with instructions to identify a device under test, selected from at least one member of the plurality of energy storage devices to perform an electrical test. Then, adjust a charge in the secondary energy storage device to a target voltage through the power multiplexer by transferring energy between the secondary energy storage device and a support device, selected from at least one member of the plurality energy storage devices. After that, transfer electrical power through the power multiplexer and power converter circuit to the device under test in order to perform the electrical test. Finally, complete the electrical test. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313020 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/364 (20190101) G01R 31/386 (20190101) Original (OR) Class G01R 31/392 (20190101) G01R 31/3842 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210334081 | Chong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederic T. Chong (Chicago, Illinois); Yunong Shi, I (Chicago, Illinois); Nelson Leung (Chicago, Illinois); Pranav Gokhale (Chicago, Illinois); Henry Hoffmann (Chicago, Illinois); David Schuster (Chicago, Illinois) |
| ABSTRACT | A quantum computing system includes a quantum processor having a plurality of qubits, a classical memory, and a classical processor. The classical processor is configured to compile a quantum program into logical assembly instructions in an intermediate language, aggregate the logical assembly instructions together into a plurality of logical blocks of instructions, generate a logical schedule for the quantum program based on commutativity between the plurality of logical blocks, generate a tentative physical schedule based on the logical schedule, the tentative physical schedule includes a mapping of the logical assembly instructions in the logical schedule onto the plurality of qubits of the quantum processor, aggregate instructions together within the tentative physical schedule that do not reduce parallelism, thereby generating an updated physical schedule; generate optimized control pulses for the aggregated instructions, and execute the quantum program on the quantum processor with the optimized control pulses and the updated physical schedule. |
| FILED | Thursday, September 12, 2019 |
| APPL NO | 17/273938 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/443 (20130101) Original (OR) Class G06F 9/48 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210334441 | Wu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongqi Wu (College Station, Texas); Xiangtian Zheng (College Station, Texas); Le Xie (College Station, Texas); Dileep Kalathil (College Station, Texas); Miroslav Begovic (College Station, Texas) |
| ABSTRACT | A method for determining a control architecture for a network of protective relays of a power distribution system. The method includes receiving data specifying a topology of a plurality of relays in the network of protective relays. The method includes sequentially modelling each relay in the network of protective relays using a reinforcement learning algorithm, including modelling each relay as an agent configured to detect one or more local conditions on the power distribution system and configured to trip based on the one or more local conditions. The method includes determining, based on the sequential modelling, one or more control parameters for each relay in the network of protective relays. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242947 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 21/06 (20130101) Electric Digital Data Processing G06F 30/27 (20200101) Original (OR) Class G06F 2113/04 (20200101) Emergency Protective Circuit Arrangements H02H 7/222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210334663 | Shen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xipeng Shen (Raleigh, North Carolina); Hui Guan (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure describes various embodiments of methods and systems of training a pruned neural network. One such method comprises defining a plurality of tuning blocks within a neural network, wherein a tuning block is a sequence of consecutive convolutional neural network layers of the neural network; pruning at least one of the plurality of tuning blocks to form at least one pruned tuning block, and pre-training the at least one pruned tuning block to form at least one pre-trained tuning block. The method further comprises assembling the at least one pre-trained tuning block with other ones of the plurality of tuning blocks of the neural network to form a pruned neural network; and training the pruned neural network, wherein the at least one pre-trained tuning block is initialized with weights resulting from the pre-training of the at least one pruned tuning block. Other methods and systems are also provided. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242691 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6228 (20130101) Computer Systems Based on Specific Computational Models G06N 3/082 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210336406 | SCARCELLI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giuliano SCARCELLI (Washington, District of Columbia); Eitan EDREI (Jerusalem, Israel) |
| ABSTRACT | A converging thermal lens is transiently formed by directing a shaped pulsed light beam having at least a first wavelength to a thermo-optic material, whereby the thermo-optic material absorbs the light beam and experiences local heating in response thereto. The heating induces a refractive index profile in the thermo-optic material that temporarily forms the converging thermal lens. In some embodiments, the refractive index of the thermo-optic material has a negative temperature dependence, and the pulsed light beam is shaped to have an inverted light pattern with a maximum intensity in an outer region of the beam cross-section. Alternatively, in some embodiments, the refractive index of the thermo-optic material has a positive temperature dependence, and the pulsed light beam is shaped to have a radially-varying light pattern with a maximum intensity in a central region of the beam cross-section. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238863 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0121 (20130101) G02F 1/0147 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/08072 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210336804 | Parhi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keshab K. Parhi (Minneapolis, Minnesota); S.V. Sandeep Avvaru (Minneapolis, Minnesota) |
| ABSTRACT | An apparatus includes a first feed-forward PUF, a second feed-forward PUF and an exclusive-or circuit configured to perform an exclusive-or operation of an output of the first feed-forward PUF and an output of the second feed-forward PUF. |
| FILED | Tuesday, April 28, 2020 |
| APPL NO | 16/860612 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3278 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210337171 | Saffman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin); ColdQuanta, Inc. (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin); ColdQuanta, Inc. (Madison, Wisconsin) |
| INVENTOR(S) | Mark Saffman (Madison, Wisconsin); Trent Michael Graham (Madison, Wisconsin); Robert Sylvester Williamson, III (Madison, Wisconsin) |
| ABSTRACT | Systems and methods for the optical control of qubits and other quantum particles with spatial light modulators (SLM) for quantum computing and quantum simulation are disclosed herein. The system may include a particle system configured to provide an ordered array comprising a multiplicity of quantum particles or a multiplicity of qubits, an optical source, a SLM configured to project a structured illumination pattern capable of individually addressing one or more quantum particles or qubits of the ordered array, and a SLM controller. |
| FILED | Monday, April 27, 2020 |
| APPL NO | 16/859743 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Optical Computing Devices; G06E 3/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Pictorial Communication, e.g Television H04N 9/312 (20130101) Original (OR) Class H04N 9/3152 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210329932 | RICHARDS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Mark P. RICHARDS (Madison, Wisconsin); Jie YIN (Madison, Wisconsin); Wenjing ZHANG (Madison, Wisconsin) |
| ABSTRACT | The disclosure provides for compositions and methods for the preservation of meat tissues, including fish, beef, poultry and pork, and meat analogs containing added heme protein, using very low amounts of phospholipase A2 (PLA2) enzymes in a combination with rosemary. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238631 |
| CURRENT CPC | Preserving, e.g by Canning, Meat, Fish, Eggs, Fruit, Vegetables, Edible Seeds; Chemical Ripening of Fruit or Vegetables; the Preserved, Ripened, or Canned Products A23B 4/18 (20130101) A23B 4/22 (20130101) Original (OR) Class Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 3/3472 (20130101) A23L 3/3571 (20130101) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2250/21 (20130101) A23V 2250/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330655 | RAJASHEKARA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gireesh RAJASHEKARA (Wooster, Ohio); Dipak KATHAYAT (Wooster, Ohio); Yosra A. HELMY (Wooster, Ohio); Loïc DEBLAIS (Wooster, Ohio) |
| ABSTRACT | Disclosed are anti-avian pathogenic E. coli (APEC) agents as well as methods of using thereof. |
| FILED | Monday, July 15, 2019 |
| APPL NO | 17/260140 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/18 (20130101) A01N 37/42 (20130101) A01N 41/10 (20130101) A01N 43/36 (20130101) A01N 43/40 (20130101) A01N 43/42 (20130101) A01N 43/50 (20130101) A01N 43/52 (20130101) A01N 43/60 (20130101) A01N 43/78 (20130101) A01N 43/82 (20130101) A01N 47/48 (20130101) Fodder A23K 20/111 (20160501) A23K 20/132 (20160501) A23K 20/137 (20160501) A23K 20/195 (20160501) A23K 50/75 (20160501) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0056 (20130101) A61K 31/10 (20130101) A61K 31/40 (20130101) A61K 31/47 (20130101) A61K 31/166 (20130101) A61K 31/216 (20130101) A61K 31/325 (20130101) A61K 31/427 (20130101) A61K 31/445 (20130101) Original (OR) Class A61K 31/495 (20130101) A61K 31/496 (20130101) A61K 31/551 (20130101) A61K 31/4164 (20130101) A61K 31/4184 (20130101) A61K 31/4525 (20130101) A61K 31/4545 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210331131 | Kersten et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip J. Kersten (Arena, Wisconsin); Thomas J. Schwartz (Orono, Maine); James A. Dumesic (Verona, Wisconsin) |
| ABSTRACT | Conducting oxidation in an inflatable bag bioreactor (or batch reactor more generally) provides an efficient, economical, and convenient reaction vessel. Rotating or rocking the inflatable bag bioreactor (or batch reactor more generally) during the reaction helps ensure continued exposure of the reaction mixture to the headspace gas in the vessel. The ability of the inflatable bag to expand or contract as the volume of the contents changes helps maintain consistent pressure and avoid the need to replenish the headspace gas. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237618 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/001 (20130101) Original (OR) Class B01J 19/0046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332489 | Claussen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Claussen (Ames, Iowa); Carmen L. Gomes (Ames, Iowa); Raquel Rainier Alves Soares (Ames, Iowa); Robert Hjort (Ames, Iowa); Cicero Cardoso Pola (Ames, Iowa) |
| ABSTRACT | Apparatus and methods of fabrication and use of highly effective laser-induced graphene (LIG) electrodes including for electrochemical sensing and catalysis. One example is a sensitive and label-free laser-induced graphene (LIG) electrode functionalized for a specific application. One example of functionalization with antibodies, an enzyme, or an ionophore to electrochemically quantify a target species The LIG electrodes were produced by laser induction on film having a carbon precursor (e.g. polyimide) in ambient conditions, and hence circumvent the need for high-temperature, vacuum environment, and metal seed catalysts commonly associated with graphene-based electrodes fabricated via chemical vapor deposition processes. These results demonstrate how LIG-based electrodes can be used for electrochemical sensing in general. Other examples of applications include, but are not limited to, ion-sensing, pesticide monitoring and detection, and water splitting, using the LIG-based electrode(s) adapted for those purposes. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/302229 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/184 (20170801) C01B 32/205 (20170801) C01B 2204/04 (20130101) C01B 2204/24 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2002/85 (20130101) C01P 2004/03 (20130101) C01P 2006/40 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 11/043 (20210101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333293 | GLADUE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DOUGLAS P. GLADUE (GUILFORD, Connecticut); AYUSHI RAI (OLD SAYBROOK, Connecticut); MANUEL V. BORCA (WESTBROOK, Connecticut) |
| ABSTRACT | Methods are provided herein utilizing a stable cell line capable of efficient infection by African swine fever virus (ASFV) and also provides for the detection of the presence of virus in samples applied to the cells. Detection of the virus by means such as red blood cell rosetting is a surprising result given that the cell line is derived from African green monkeys. This cell line provides a marked improvement over the currently available testing strategies. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236284 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/12031 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/80 (20130101) Original (OR) Class G01N 2333/01 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210331784 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John C. Lin (Seaford, Virginia); Latunia P. Melton (Yorktown, Virginia); Mehti Koklu (Hampton, Virginia); Marlyn Y. Andino (Newport News, Virginia) |
| ABSTRACT | A simple-hinged flap assembly for a winged aircraft includes a simple-hinged flap having a leading airfoil section pivotably connected to a trailing airfoil section via a hinge, and an active flow control (AFC) actuator assembly. The assembly is connected to or integrally formed with the flap and includes upstream and downstream AFC actuators arranged in respective first and second rows, and collectively configured to provide first and second outlet mass flowrates. The downstream AFC actuators emit the second outlet mass flowrate at a rate that substantially exceeds the first outlet mass flowrate, such that the first outlet mass flowrate preconditions a boundary layer around the simple-hinged flap assembly. A winged aircraft includes a pneumatic power supply, fuselage, a wing connected to the fuselage, and the simple-hinged flap assembly. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238443 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 9/02 (20130101) B64C 13/40 (20130101) Original (OR) Class Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 41/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210331791 | Geuther et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven C. Geuther (Hampton, Virginia); David D. North (Williamburg, Virginia); Robert G. McSwain (Yorktown, Virginia); Michael D. Patterson (Yorktown, Virginia); Gregory Howland (Yorktown, Virginia); Jared S. Fell (Yorktown, Virginia); Christopher M. Cagle (Yorktown, Virginia); Xiaofan Fei (Bellevue, Washington); Siena K.S. Whiteside (Poquoson, Virginia); David A. Hare (Smithfield, Virginia) |
| ABSTRACT | An aircraft wing configuration for a vertical or a short take-off and landing aircraft having a plurality of propeller-blown wings mounted at different longitudinal locations along a fuselage of the vertical take-off and landing aircraft, producing two or more lifting surfaces, fixed at a predetermined acute wing angle greater than 0° and substantially less than 90° relative to a horizontal plane, and having a plurality of flaps disposed behind the wings. The configuration has a plurality of propellers distributed in front of the plurality of wings producing two or more lifting surfaces and mounted such that the wings are externally blown by forced airstreams from the propellers. The propellers produce distributed thrust components, and the plurality of flaps are in the forced airstreams of the propellers when one or more of the flaps is in an extended position. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 16/857954 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 9/00 (20130101) B64C 9/04 (20130101) B64C 11/46 (20130101) B64C 13/02 (20130101) B64C 29/0025 (20130101) Original (OR) Class B64C 39/08 (20130101) B64C 2009/005 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 31/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333019 | Sercel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trans Astronautica Corporation (Lake View Terrace, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joel C. Sercel (Lake View Terrace, California); Craig Peterson (Los Angeles, California); Anthony Longman (Woodland Park, Colorado) |
| ABSTRACT | Systems and methods are disclosed for directing radiant energy to permanently shadowed or occasionally shadowed regions such as on the floors of craters or in valleys in lunar polar regions to provide illumination, thermal power, electricity, communications, and other services. Embodiments of the systems include reflector elements to provide diffuse illumination, focused illumination, and thermal power, structures to support the reflectors and other elements, communications devices for varied signal types, and methods for installing the system. The structure can be compactly folded and delivered to be automatically installed. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/205610 |
| CURRENT CPC | Solar Heat Collectors; Solar Heat Systems F24S 20/20 (20180501) F24S 20/60 (20180501) F24S 23/70 (20180501) Original (OR) Class F24S 50/20 (20180501) F24S 2020/23 (20180501) F24S 2023/872 (20180501) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/10 (20141201) H02S 30/10 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20210334289 | Banerjee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Morgan State University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Snehanshu Banerjee (Edgewood, Maryland); Mansoureh Jeihani (Timonium, Maryland); Mahmoud Ayman Sayed (Cairo, Egypt) |
| ABSTRACT | Computer-implemented systems and methods are provided for the synchronization of data from asynchronous datasets to form a merged, synchronized data set, and more particularly to systems and methods for merging disparate and asynchronous data sets that include common dimensions, such as space and time dimensions, and more particularly space and time data relating to a driving simulation environment (such as driving simulator data and eye tracking data having disparate time data resolutions), to enable data extraction from and analysis of the merged, synchronized data set. A driving simulator system includes a driver interface having driving controls and a display and creates driving simulator data files for each driver of the driving simulator system having data entries that are captured at a first timing frequency. Likewise, an eye tracking system includes eye tracking cameras for tracking a driver's eye movements when using the driving simulator system and creates eye tracking data files for each driver of the driving simulator system having data entries that are captured at a second timing frequency that is different from the first timing frequency at which driving simulator data is captured. A driving behavior analysis computer is also provided that merges the asynchronous data embodied in each of the driving simulator data files and the eye tracking data files to form a single merged data file based upon an interpolation of data entries in those data files. The merged data files may then be further processed to enable extraction and analysis of the merged data in order to identify various driver behaviors. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237630 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/013 (20130101) G06F 16/254 (20190101) Original (OR) Class G06F 30/20 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00604 (20130101) Pictorial Communication, e.g Television H04N 5/247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210335117 | Duggan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado); The Board of Regents, University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gerald Patrick Duggan (Fort Collins, Colorado); Kathleen Maron Smits (Southlake, Texas); Riley DeWitt Ancona (Broomfield, Colorado); Younki Cho (Dallas, Texas) |
| ABSTRACT | Gas monitoring network and deployment systems and methods are described for detecting gas leaks (e.g., natural gas leaks) from gas infrastructures (e.g., buried natural gas) within residential, commercial, rural, and industrial areas. A method of deployment involves placing detector systems indoor and outdoor environments in distinct patterns, providing early warning or long-term monitoring of gas leaks via data communication technologies. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/232391 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/18 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/01 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/16 (20130101) Original (OR) Class G08B 25/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210332093 | POZZI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee); The United States as Represented by The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ambra A. POZZI (Nashville, Tennessee); Manuel CHIUSA (Nashville, Tennessee); Jack J. HAWIGER (Nashville, Tennessee); Jozef ZIENKIEWICZ (Nashville, Tennessee) |
| ABSTRACT | Disclosed herein are compositions and methods for inhibiting collagen production mediated by the Fused in Sarcoma (FUS) ribonucleoprotein. As disclosed herein, the C terminal domain of FUS contains an uncommon nuclear localization sequence (NLS) motif called PY-NLS that binds the nuclear import receptor transportin. Phosphorylation of FUS leads to its association with transportin and nuclear translocation with consequent increased in collagen production. Therefore, disclosed herein is an isolated peptide having a transportin-binding moiety, which inhibits FUS from binding transportin, linked to a membrane translocating motif. These compositions and methods can be used to inhibit FUS-mediated collagen production, and treat fibrotic disease involving FUS-mediated collagen accumulation in kidneys and other organs displaying fibrotic diseases. |
| FILED | Monday, January 29, 2018 |
| APPL NO | 16/481128 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 38/1777 (20130101) A61K 38/1825 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Peptides C07K 14/50 (20130101) C07K 14/4703 (20130101) Original (OR) Class C07K 14/70557 (20130101) C07K 2319/02 (20130101) C07K 2319/10 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210332118 | Clauss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthias Clauss (Indianapolis, Indiana); Irina Petrache (Indianapolis, Indiana); Robert Voswinckel (Geissen, Germany) |
| ABSTRACT | The present invention provides methods for diagnosing a patient with emphysema, COPD of lung injury caused by tobacco use by detecting the levels of EMAP II in a sample. Disclosed herein are the hypervariable regions for a rat monoclonal antibody that binds to a form of EMAP II. This disclosure also includes a polypeptide sequence included in EMAP II that is the target for the binding of the antibody to its target protein. This epitope serves as the basis for a humanized antibody that can be used to treat patients that suffer from pathologies that exhibit elevated levels of EMAP II expression. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/198031 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) C07K 16/22 (20130101) Original (OR) Class C07K 16/2866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20210330414 | So et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ViaCyte, Inc. (San Diego, California) |
| ASSIGNEE(S) | ViaCyte, Inc. (San Diego, California) |
| INVENTOR(S) | Vincent So (San Diego, California); Erik Olson (San Diego, California); Michael Scott (San Diego, California); Chad Green (San Diego, California); Giacomo Strollo (San Diego, California); Gustavo Prado (San Diego, California); Craig McGreevy (San Diego, California); Laura Martinson (San Diego, California); Donald Koenig (San Diego, California) |
| ABSTRACT | Embodiments herein describe tools and instruments for holding, transferring, delivering, deploying an implantable device and methods and means of aseptically storing and shipping the implantable device including but not limited to a device case for protecting, housing and filling the device, a surgical sizer for preparing the implantable site, a deployer for transferring the implantable device from the device case and delivering or deploying the implantable device at the prepared implantable site. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/367203 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 50/00 (20160201) Original (OR) Class A61B 2050/0067 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210330597 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NEW JERSEY INSTITUTE OF TECHNOLOGY (Newark, New Jersey) |
| ASSIGNEE(S) | NEW JERSEY INSTITUTE OF TECHNOLOGY (Newark, New Jersey) |
| INVENTOR(S) | Xiaoyang Xu (Livingston, New Jersey); Zhongyu Li (Harrison, New Jersey); William Ho (Newark, New Jersey) |
| ABSTRACT | One aspect of the disclosure describes a lipid conjugated cationic molecule. Other aspects of the disclosure describes nanoparticle delivery systems and methods of making the systems are disclosed. An embodiment of the nanoparticle delivery system has sustained gene delivery properties, the nanoparticle delivery system can be synthesized using biodegradable and biocompatible polymers via self-assembly. The nanoparticle delivery system comprises a plurality of nanoparticle depots, each of which has a particle-in-particle structure, and is composed of a polymeric nanoparticle, which encapsulates cationic molecule/nucleic acid complexes, facilitating enhanced retention and prolonged release of the gene payload. The polymeric nanoparticle comprises a shell, and a nanocomplex of the cationic molecule and a polynucleotide, the nanocomplexes are distributed within the shell and/or embedded in the shell. Another embodiment of the nanoparticle delivery system has one or more nanocomplexes. The one or more nanocomplexes includes a lipid conjugated cationic molecule and a polynucleotide. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240405 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1652 (20130101) A61K 9/5115 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20210335452 | Beal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Stuart Michael Beal (Iowa City, Iowa); Thomas Cushing Mitchell (Boston, Massachusetts); Daniel Wyschogrod (Newton, Massachusetts) |
| ABSTRACT | According to an example, a method of analyzing an output of a sequencer is provided comprising identifying genetic targets, obtaining target signature snippets responsive thereto, each target signature snippet derived from a genetic sequence of the genetic targets, receiving portions of a test sequence output by a sequencer sequencing a sample in real time, determining, in real time or near-real time with the sequencer sequencing the sample, whether a target signature snippet of the target signature snippets is in at least one portion of the test sequence, determining, for each genetic target, a probability the genetic target is in the sample based on the determination of whether the target signature snippet is present in the at least one portion of the test sequence, and outputting an analysis of the sample indicating the respective probability that each genetic target is present in the sample. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181865 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) Original (OR) Class G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210335454 | Beal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Stuart Michael Beal (Iowa City, Iowa); Thomas Cushing Mitchell (Boston, Massachusetts); Daniel Wyschogrod (Newton, Massachusetts); Allison Jordan Taggart (Portsmouth, Rhode Island) |
| ABSTRACT | According to at least one example, a method of filtering signature snippets is provided comprising identifying a group of genetic targets, obtaining a plurality of sets of one or more target signature snippets responsive to identifying the group of genetic targets, each set of one or more target signature snippets corresponding to a respective genetic target of the group of genetic targets and being derived from a genetic sequence of the respective genetic target, filtering the plurality of sets of one or more target signature snippets to identify a set of one or more universal target signature snippets, and outputting the set of one or more universal target signature snippets. |
| FILED | Monday, February 22, 2021 |
| APPL NO | 17/181858 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) G16B 40/00 (20190201) Original (OR) Class G16B 45/00 (20190201) G16B 50/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20210330414 | So et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ViaCyte, Inc. (San Diego, California) |
| ASSIGNEE(S) | ViaCyte, Inc. (San Diego, California) |
| INVENTOR(S) | Vincent So (San Diego, California); Erik Olson (San Diego, California); Michael Scott (San Diego, California); Chad Green (San Diego, California); Giacomo Strollo (San Diego, California); Gustavo Prado (San Diego, California); Craig McGreevy (San Diego, California); Laura Martinson (San Diego, California); Donald Koenig (San Diego, California) |
| ABSTRACT | Embodiments herein describe tools and instruments for holding, transferring, delivering, deploying an implantable device and methods and means of aseptically storing and shipping the implantable device including but not limited to a device case for protecting, housing and filling the device, a surgical sizer for preparing the implantable site, a deployer for transferring the implantable device from the device case and delivering or deploying the implantable device at the prepared implantable site. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/367203 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 50/00 (20160201) Original (OR) Class A61B 2050/0067 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333209 | YUAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | BAOHONG YUAN (Arlington, Texas) |
| ABSTRACT | A method of imaging comprises disposing a population of first targeting ultrasound-switchable fluorophores and a population of second non-targeting ultrasound-switchable fluorophores in an environment; detecting a first photoluminescence signal emitted by the population of first targeting fluorophores, and a second photoluminescence signal emitted by the population of second non-targeting fluorophores; determining a photoluminescence property of the population of second non-targeting fluorophores from the second photoluminescence signal; and using the determined photoluminescence property of the population of second non-targeting fluorophores to deconvolute the first photoluminescence signal into the population of first targeting fluorophores bound and unbound to a first target binding element in the environment. |
| FILED | Tuesday, March 05, 2019 |
| APPL NO | 16/977959 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0058 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) Original (OR) Class G01N 33/542 (20130101) G01N 33/5091 (20130101) G01N 2021/6441 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Education (ED)
| US 20210330242 | Huggins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jane E. Huggins (Fenton, Michigan); Seth Warschausky (Ann Arbor, Michigan); Ramses Eduardo Alcaide (Ann Arbor, Michigan) |
| ABSTRACT | Methods, systems, apparatus, and non-transitory computer readable media are disclosed utilizing brain-computer interfaces (BCIs). Various embodiments are disclosed to allow a user to directly select multiple-choice answers, to provide motorized wheelchair controls, and to allow a user to play a game via the BCI. When used in a cognitive assessment test, embodiments include the administration of unmodified standardized tests with results in the same or a similar format as those taken without a BCI. Various embodiments are disclosed to improve the accuracy of BCI test administration using a three-step process for each test question, which includes determining whether the user intends to select an answer, monitoring user brain activity to determine a selected answer, and verifying the selected answer. In addition, the selected answer may be verified by monitoring user brain activity in accordance with a hold-release process to determine whether a user intends to initiate a state change. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/368207 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/316 (20210101) A61B 5/374 (20210101) A61B 5/378 (20210101) A61B 5/742 (20130101) A61B 5/4088 (20130101) Original (OR) Class A61B 5/7221 (20130101) A61B 5/7264 (20130101) A61B 5/7267 (20130101) A61B 5/7282 (20130101) A61B 5/7435 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) A61F 4/00 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210330328 | Dreilinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NeuraMedica Inc. (Oregon City, Oregon) |
| ASSIGNEE(S) | NeuraMedica Inc. (Oregon City, Oregon) |
| INVENTOR(S) | Rachel Dreilinger (Beavercreek, Oregon); Neil Roundy (Eugene, Oregon); Mariah Knight (Cornelius, Oregon); Sandra Baker (Tigard, Oregon) |
| ABSTRACT | A medical device forming method, an applier for manipulating clips, and a cartridge for holding clips are disclosed herein. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 16/858546 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/083 (20130101) Original (OR) Class A61B 17/1222 (20130101) A61B 2017/0488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 20210329902 | Acharya et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Soumyadipta Acharya (Ellicott City, Maryland); William Patterson (Reisterstown, Maryland); Margaret Glancey (Thurmont, Maryland); Nicholas Radant (Baltimore, Maryland); Justin Chang (Baltimore, Maryland); Kimberly Ashman (New Orleans, Louisiana) |
| ABSTRACT | A mosquito surveillance device includes one or more mosquito traps having a camera capable of taking images of mosquitos and transmitting the images electronically to a receiver. Suitable traps include an ovitrap, for example. Images may be transmitted from inside or outside the trap to a receiver using low bandwidth cellular phone networks. The images are processed and displayed using software forming mosquito data. The images may be analyzed and the number of live mosquitos identified, the number of dead mosquitos identified, the species of mosquitos identified, or mapped vector densities in real time identified preferably at high resolution. |
| FILED | Friday, January 26, 2018 |
| APPL NO | 16/479634 |
| CURRENT CPC | Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants A01M 1/026 (20130101) Original (OR) Class A01M 1/106 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00362 (20130101) G06K 9/00771 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20210334747 | Bornitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carrie Ann Bornitz (Sioux Falls, South Dakota); Robert E. Dixon, JR. (Haymarket, Virginia); Ryan M. Luckay (Vienna, Virginia) |
| ABSTRACT | Systems and methods of creating, managing, and distributing supplemental content associated with items in a distribution network. A physical delivery item can be imaged and associated with additional content generated or associated with the sender of the physical delivery item. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/366807 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0833 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20210332711 | Pratt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William S. Pratt (West Hartford, Connecticut); Christopher J. Knortz (West Hartford, Connecticut) |
| ABSTRACT | A rotor assembly for a piece of rotational equipment includes a rotor disk configured to rotate about a rotational axis. The rotor disclose includes a first rotor attachment member including a first mount slot and a second rotor attachment member including a second mount slot. The rotor disk further includes an outer diameter surface extending between the first rotor attachment member and the second rotor attachment member. The rotor assembly further includes a rotor blade including an airfoil, a platform, a first mount portion retained within the first mount slot, and a second mount portion retained within the second mount slot. The platform includes an inner platform surface facing the outer diameter surface. The rotor disk and the rotor blade define a circumferential portion of a circumferentially-extending cavity between the inner platform surface, the outer diameter surface, the first rotor attachment member, and the second rotor attachment member. |
| FILED | Monday, April 27, 2020 |
| APPL NO | 16/859569 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/082 (20130101) F01D 5/3015 (20130101) F01D 11/001 (20130101) Original (OR) Class F01D 11/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210333038 | DALLY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Morris, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | Adam G. DALLY (Champlin, Minnesota); Chad J. LANGNESS (Robbinsdale, Minnesota); Charles Spencer NICHOLS (Marietta, Georgia); Stephan F. FURLICH (Minnetonka, Minnesota) |
| ABSTRACT | An experimental payload and cryogenic system are provided. An experimental payload including a cryogenic chamber is provided. The cryogenic chamber includes an action chamber configured to be cryogenically cooled to an action temperature. The cryogenic chamber also includes an inner cooling ring cooled via an internal braiding system. The inner cooling ring is configured to operate at a first temperature. The cryogenic chamber further includes an outer ring in communication with the inner cooling ring. The outer ring is configured to absorb heat from the experimental payload. The outer ring defines a second temperature that is greater than the first temperature. The cryogenic chamber also includes a plurality of legs operably coupled to the cryogenic chamber at a top end of each leg. The legs are characterized by a low thermal conductivity and the experimental payload is configured to be attached to a base of a cryocooler. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 16/856719 |
| CURRENT CPC | Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 11/04 (20130101) F25D 19/006 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210336610 | GALAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ELIAS J. GALAN (BALTIMORE, Maryland) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| INVENTOR(S) | ELIAS J. GALAN (BALTIMORE, Maryland) |
| ABSTRACT | One example includes a superconducting latch system. The system includes a first input stage configured to receive a first input pulse and a second input stage configured to receive a second input pulse. The system also includes a storage loop configured to switch from a first state to a second state in response to receiving the first input pulse, and to switch from the second state to the first state in response to the second input pulse. The first state corresponds to no flux in the storage loop and the second state corresponds to a flux in the storage loop. The system further includes an output stage configured to generate an output pulse in the second state of the storage loop. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 16/857325 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0356 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/223 (20130101) Pulse Technique H03K 3/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, October 28, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page