FedInvent™ Patent Applications
Application Details for Thursday, November 11, 2021
This page was updated on Friday, November 12, 2021 at 07:40 AM GMT
Department of Health and Human Services (HHS)
| US 20210345867 | GEORGAKOUDI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Boston, Massachusetts); Lahey Clinic, Inc. (Burlington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Irene GEORGAKOUDI (Acton, Massachusetts); Martin HUNTER (Bradford, Massachusetts); Robert Michael TROUT (Medford, Massachusetts); Thomas SCHNELLDORFER (Arlington, Massachusetts) |
| ABSTRACT | Methods and apparatus for improved imaging of internal tissue structures, such as lesions in the peritoneum, are disclosed employing Differentially Polarized Light (DPL) imaging. The optical system can include a laparoscope having at least one optical illumination waveguide for directing illuminating radiation and an optical collection waveguide having an aperture for collecting and transmitting radiation backscattered from a tissue region to a detector. The system further can include a polarizer for polarizing the illuminating radiation and a second analyzing polarizer disposed in the optical return path, whereby backscattered radiation of differing polarizations can be passed to the detector. End cap assemblies are also disclosed that that can be fitted to conventional laparoscopes, e.g., by a threaded connection or the like, to facilitate DPL imaging by polarizing the illuminating light of the laparoscope. For example, the end cap can include a polarizing film within a stainless steel housing. The polarizing film can be shaped to cover of the illumination outputs of the laparoscope, while leaving clear the aperture for collection of reflected or scattered radiation. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/284413 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/07 (20130101) A61B 1/042 (20130101) A61B 1/00096 (20130101) A61B 1/00128 (20130101) A61B 1/00137 (20130101) A61B 1/0638 (20130101) A61B 1/0646 (20130101) Original (OR) Class A61B 1/0669 (20130101) A61B 1/3132 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210345958 | Rottmann et al. |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
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| INVENTOR(S) | Markus Rottmann (Chicago, Illinois); Rishi K. Arora (Chicago, Illinois); David A. Johnson (Romeoville, Illinois); Shin Yoo (Wilmette, Illinois) |
| ABSTRACT | A system for treating atrial fibrillation includes a memory configured to store a baseline measurement of an atrial fibrillation characteristic of a patient and a post administration measurement of the atrial fibrillation characteristic of the patient. The post administration measurement is obtained subsequent to administration of a reactive oxygens species (ROS) scavenger to the patient. The system also includes a processor operatively coupled to the memory and configured to determine a change between the baseline measurement and the post administration measurement of the atrial fibrillation characteristic. The processor is further configured to identify, based on the determined change, one or more hot spots of atrial fibrillation, where the one or more hot spots comprise target areas for treatment of the atrial fibrillation. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308756 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/339 (20210101) A61B 5/361 (20210101) A61B 5/4848 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346096 | HE et al. |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | Bin HE (Pittsburgh, Pennsylvania); Rui SUN (Pittsburgh, Pennsylvania); Abbas SOHRABPOUR (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are methods and apparatus for the imaging of brain electrical activity from electromagnetic measurements, using deep learning neural networks where a simulation process is designed to model realistic brain activation and electromagnetic signals to train generalizable neural networks and a residual convolutional neural network and/or a recurrent neural network is trained using the simulated data, capable of estimating source distributions from electromagnetic measurements, and their temporal dynamics over time, for pathological signals in diseased brains, such as interictal activity and ictal signals, and physiological brain signals such as evoked brain responses and spontaneous brain activity. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/315691 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/245 (20210101) A61B 5/369 (20210101) A61B 34/10 (20160201) Original (OR) Class A61B 2034/105 (20160201) Electric Digital Data Processing G06F 30/23 (20200101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346307 | Xu |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
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| INVENTOR(S) | Qiaobing Xu (Lexington, Massachusetts) |
| ABSTRACT | Disclosed are (i) compounds of formula I, or pharmaceutically acceptable salts thereof; and (ii) lipidoid nanoparticles comprising compound of formula I or pharmaceutically acceptable salts thereof, as well as their use as vehicles for drug delivery across the blood-brain barrier. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/339563 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 38/45 (20130101) A61K 45/06 (20130101) Acyclic or Carbocyclic Compounds C07C 215/20 (20130101) C07C 323/58 (20130101) Heterocyclic Compounds C07D 209/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346309 | GONG et al. |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
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| INVENTOR(S) | Shaoqin GONG (Middleton, Wisconsin); Guojun CHEN (Madison, Wisconsin) |
| ABSTRACT | Provided are a unimolecular nanoparticle, a composition thereof, and methods of use thereof, and includes 1) a dendritic polymer having a molecular weight of about 500-120,000 Da and terminating in hydroxyl, amino or carboxylic acid groups; 2) cationic polymers attached to at least a majority of the terminating groups of the dendritic polymer via a pH-sensitive linker, wherein each cationic polymer comprises a polymeric backbone attached to cationic functional groups and to weakly basic groups by disulfide bonds, wherein the molar ratio of cationic functional groups to weakly basic groups ranges from 1:1-5:1, and has a molecular weight from about 1,000-5,000 Da; and 3) poly(ethylene glycol) attached to a plurality of cationic polymers and having a terminal group selected from a targeting ligand, OH, O-alkyl, NH2 , biotin, or a dye, wherein the terminal group of at least one poly(ethylene glycol) is having a molecular weight of about 1,000-15,000 Da. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331012 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) Original (OR) Class A61K 9/5192 (20130101) A61K 31/713 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346319 | Arbiser |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
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| INVENTOR(S) | Jack Arbiser (Atlanta, Georgia) |
| ABSTRACT | In certain embodiments, this disclosure relates to methods of treating or preventing angiogenic disorders such as cancer, skin cancer, angiogenic disorders of the skin, and inflammatory disorders comprising administering an effective amount of a composition comprising (R)-(+)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol or salt thereof in enantiomeric excess to a subject in need thereof. In certain embodiments, this disclosure contemplates compositions or pharmaceutical compositions comprising (R)-(+)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol or salt thereof in enantiomeric excess as reported herein. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 17/282632 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/138 (20130101) Original (OR) Class A61K 31/165 (20130101) A61K 31/167 (20130101) A61K 31/337 (20130101) A61K 31/404 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/4184 (20130101) A61K 31/4745 (20130101) A61K 31/5377 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346326 | Gabrilovich |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Dmitry I. Gabrilovich (Villanova, Pennsylvania) |
| ABSTRACT | A method of identifying a population of PMN-MDSC-Like Cells (PM-LCs) distinguishable from myeloid derived suppressor cells (PMN-MDSCs). A method for treating a cancer comprising identifying PM-LCs and/or administering an agent that alters neutrophil migration to reduce or inhibit tumor cell seeding, tumor metastasis, or metastatic niche formation in a subject. Compositions for use in diagnosing and treating cancer that comprise antagonists and/or inhibitors of genes and cellular process to alter PM-LC activity. |
| FILED | Monday, October 14, 2019 |
| APPL NO | 17/284993 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/185 (20130101) Original (OR) Class A61K 31/436 (20130101) A61K 31/438 (20130101) A61K 31/513 (20130101) A61K 31/7076 (20130101) A61K 31/7084 (20130101) A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346337 | Chang et al. |
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| APPLICANT(S) | The Research institute at Nationwide Children's Hospital (Columbus, Ohio) |
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| INVENTOR(S) | Long-Sheng Chang (Hilliard, Ohio); A. Douglas Kinghorn (Columbus, Ohio) |
| ABSTRACT | A method of treating nervous system cancer or soft-tissue sarcoma in a subject is described. The method includes administering a therapeutically effective amount of a compound according to formula I to a subject in need thereof: wherein R1 is selected from the group consisting of —OH, —OAc, —OCHO, ═O, and ═NOH; R2 is selected from the group consisting of —CON(CH3)2, —CONHCH3, —CONH2, —COOCH3, —COOH, and —H, R3 is selected from the group consisting of —H, —OH, and —OCH3, and R4 is selected from the group consisting of —OH, —OCH3, —OCH2CH3. |
| FILED | Wednesday, October 09, 2019 |
| APPL NO | 17/284112 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 31/343 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346345 | JACOBSEN et al. |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
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| INVENTOR(S) | JACOB P.R. JACOBSEN (Durham, North Carolina); MARC G. CARON (Hillsborough, North Carolina) |
| ABSTRACT | Provided are methods of enhancing bioavailability of enterally administered 5-hydroxytryptophan (5-HTP) in a subject in need thereof, said method comprising enterally co-administering low-dose carbidopa with said 5-HTP, as well as pharmaceutical formulations useful for the same. In some embodiments, the 5-HTP and/or low-dose carbidopa are provided as slow-release formulation(s). |
| FILED | Monday, January 28, 2019 |
| APPL NO | 15/733423 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/15 (20130101) A61K 31/135 (20130101) A61K 31/138 (20130101) A61K 31/198 (20130101) A61K 31/343 (20130101) A61K 31/405 (20130101) Original (OR) Class A61K 31/454 (20130101) A61K 31/495 (20130101) A61K 31/496 (20130101) A61K 31/4406 (20130101) A61K 31/4525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346354 | Thompson et al. |
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| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan-Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Craig B. Thompson (New York, New York); Wilhelm Palm (New York, New York) |
| ABSTRACT | Disclosed herein are compositions and methods for detecting and treating cancer. In some embodiments, the cancer is characterized by activation of Ras. |
| FILED | Friday, April 23, 2021 |
| APPL NO | 17/238273 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) A61K 31/366 (20130101) A61K 31/436 (20130101) Original (OR) Class A61K 31/7036 (20130101) A61K 45/06 (20130101) A61K 47/643 (20170801) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/76 (20130101) C07K 2319/55 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5748 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346355 | MARAMBAUD |
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| APPLICANT(S) | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (Manhasset, New York) |
| ASSIGNEE(S) | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (Manhasset, New York) |
| INVENTOR(S) | Philippe MARAMBAUD (Astoria, New York) |
| ABSTRACT | Methods and pharmaceutical compositions comprising one or more mTOR inhibitors such as sirolimus and one or more receptor tyrosine kinase inhibitors such as nintedanib are disclosed for treating vascular lesions and hereditary hemorrhagic telangiectasia. |
| FILED | Tuesday, September 24, 2019 |
| APPL NO | 17/274725 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) Original (OR) Class A61K 31/496 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346365 | BAUR et al. |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the Universtiy of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Joseph BAUR (Merion Station, Pennsylvania); Sarmistha Mukherjee (Blue Bell, Pennsylvania) |
| ABSTRACT | The invention includes methods, kits, and pharmaceutical compositions for enhancing liver regeneration in a mammal in need thereof, comprising administering a therapeutically effective amount of an agent that increases nicotinamide adenine dinucleotide (NAD) activity. The methods may include administering a therapeutically effective amount of an agent that increases nicotinamide adenine dinucleotide (NAD) activity and a sirtuin 1 (Sirt1) agonist. The agent that increases NAD activity may be a NAD precursor. The NAD precursor may include one or more of tryptophan, nicotinic acid, nicotinic acid riboside, nicotinamide riboside (NR), nicotinamide, NADP, and NAD itself, and a pharmaceutically acceptable salt thereof. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/385291 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/455 (20130101) Original (OR) Class A61K 31/706 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346367 | Kahne et al. |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Suzanne Walker Kahne (Cambridge, Massachusetts); Sara Evelyn Schwanger Martin (Cambridge, Massachusetts); Craig Joseph Thomas (Gaithersburg, Maryland); Damien Yves Duveau (Germantown, Maryland) |
| ABSTRACT | Provided herein are O-GlcNAc transferase (OGT) inhibitor compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases (e.g., diabetes and complications thereof, neurodegenerative diseases, proliferative diseases such as cancers, autoimmune diseases, and inflammatory diseases) in a subject. Provided are methods of inhibiting OGT in a subject or biological sample. |
| FILED | Thursday, August 29, 2019 |
| APPL NO | 17/271793 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) Original (OR) Class A61K 45/06 (20130101) Heterocyclic Compounds C07D 409/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346373 | NEWMAN et al. |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
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| INVENTOR(S) | Amy Hauck NEWMAN (Phoenix, Maryland); Vivek KUMAR (Baltimore, Maryland); Anver Basha SHAIK (Baltimore, Maryland) |
| ABSTRACT | Disclosed herein are novel methods of treating pain in a patient in need thereof by providing to the patient a selective dopamine D3 receptor antagonist/partial agonist which when used with an opioid analgesic, can mitigate the development of opioid dependence, by preventing the need for dose escalation while either maintaining the opioid analgesic effect or providing analgesia with a lower dose of the opioid. In addition, the D3 antagonists/partial agonists described herein may be used to augment the effectiveness of current Medication Assisted Treatment regimens (e.g. methadone or buprenorphine) for the treatment of opioid use disorders. |
| FILED | Monday, September 09, 2019 |
| APPL NO | 17/265150 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/485 (20130101) A61K 31/496 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/36 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346395 | GRAY et al. |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (BOSTON, Massachusetts) |
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| INVENTOR(S) | NATHANAEL S. GRAY (BOSTON, Massachusetts); JAEBONG JANG (BOSTON, Massachusetts); DRIES DE CLERCQ (WETTEREN, Belgium); DAVID A. SCOTT (BOSTON, Massachusetts) |
| ABSTRACT | The application relates to compounds, or pharmaceutically acceptable salts, hydrates, solvates, or stereoisomers thereof, which modulate the activity of EGFR, a pharmaceutical composition comprising said compounds, and methods of treating or preventing a disease in which EGFR plays a role. |
| FILED | Friday, June 21, 2019 |
| APPL NO | 17/251559 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/5513 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 243/14 (20130101) C07D 401/12 (20130101) C07D 403/04 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346413 | Imai et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Shin-ichiro Imai (St. Louis, Missouri); Rajendra Apte (Clayton, Missouri) |
| ABSTRACT | Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases and conditions, including age-related obesity, age-related increases in blood lipid levels, age-related decreases in insulin sensitivity, age-related decreases in memory function, and age-related changes in eye function such as macular degeneration. The methods comprise administering nicotinamide mononucleotide (NMN) to a subject. In some embodiments, the administration can be oral administration. Also disclosed are pharmaceutical compositions comprising NMN. |
| FILED | Friday, January 15, 2021 |
| APPL NO | 17/150584 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0048 (20130101) A61K 9/0053 (20130101) A61K 31/455 (20130101) A61K 31/706 (20130101) Original (OR) Class A61K 31/7064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346420 | Feng |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Gen-Sheng Feng (La Jolla, California) |
| ABSTRACT | Provided herein are combination immunotherapies and methods of use for cancer treatment, in particular for the treatment of early and late stage liver cancer. Specifically, administration of polyIC with a PD-L1 antibody together effectively suppresses tumor progression after oncogene delivery. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 17/283683 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346424 | Schoenfisch et al. |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Mark H. Schoenfisch (Chapel Hill, North Carolina); Haibao Jin (Carrboro, North Carolina) |
| ABSTRACT | Disclosed herein are cyclodextrin molecules covalently modified to store and release nitric oxide, as well as methods of making and uses thereof. The covalently modified cyclodextrin molecules may be tailored, in several embodiments, to release nitric oxide in a controlled manner and are useful for reduction and/or eradication of bacteria and for the treatment of disease. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/321677 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/724 (20130101) Original (OR) Class A61K 47/6951 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Polysaccharides; Derivatives Thereof C08B 37/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346430 | Zhuang et al. |
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| APPLICANT(S) | Oaiscell Biotechnologies (Potomac, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhengping Zhuang (Bethesda, Maryland); Kaiyong Yang (Potomac, Maryland); Jing Cui (Potomac, Maryland); Qi Zhang (Hangzhou, Zhejiang, China PRC) |
| ABSTRACT | Disclosed is a method for treating glioblastoma or other brain tumors. The method includes steps of preparing cells comprising a chimeric antigen receptor (CAR) molecule and administering to a mammal in need thereof an effective amount of the prepared cells. Also disclosed is that the CAR molecule contains an antigen binding domain that binds to the tumor antigen associated with the glioblastoma or other brain tumors, and the tumor antigen is carbonic anhydrase IX. |
| FILED | Friday, August 23, 2019 |
| APPL NO | 16/652230 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346462 | Siracusa et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Mark C. Siracusa (Princeton, New Jersey); Jacques Y. Roberge (Princeton, New Jersey) |
| ABSTRACT | Methods are provided for reducing type 2 cytokine-mediated inflammation, for example by reducing IL-5 and Il-13 activity, using native and variant neuromedin B (Nmb) peptides or coding sequences. Such methods can be used to treat an inflammatory disorder, such as asthma, COPD or an allergic reaction. Also provided are modified Nmb peptides. |
| FILED | Thursday, October 03, 2019 |
| APPL NO | 17/282883 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 31/5575 (20130101) A61K 38/105 (20130101) Original (OR) Class A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/08 (20180101) A61P 37/06 (20180101) A61P 37/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346463 | TRAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dat TRAN (Alhambra, California); Justin SCHAAL (Orange, California); Patti TRAN (Alhambra, California); Michael E. SELSTED (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dat TRAN (Alhambra, California); Justin SCHAAL (Orange, California); Patti TRAN (Alhambra, California); Michael E. SELSTED (Pasadena, California) |
| ABSTRACT | Compositions are provided for formulations of θ-defensin and/or a θ-defensin analog that are highly suitable for parenteral administration. Such formulations provide the θ-defensin and/or a θ-defensin analog in a slightly acidic buffer that includes propylene glycol. Surprisingly, Inventors have found that such formulation increase bioavailability of a θ-defensin and/or a θ-defensin analog so provided by at least a factor of 10 relative to conventional isotonic saline solutions, and that such formulations dramatically improved bioavailability in human subjects relative to animal models. Inventors have also found that such formulations advantageously exhibit low viscosity at high peptide concentrations, reducing injection volume permitting sterilization by simple filtration. |
| FILED | Wednesday, October 09, 2019 |
| APPL NO | 17/283384 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) Original (OR) Class A61K 47/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346473 | McIvor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); REGENXBIO Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Scott McIvor (St. Louis Park, Minnesota); Lalitha R. Belur (St. Paul, Minnesota); Walter Low (Shorewood, Minnesota); Carolyn Fairbanks (St. Paul, Minnesota); Karen Kozarsky (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | A method to prevent, inhibit or treat one or more symptoms associated with a disease of the central nervous system by intrathecally, intracerebroventricularly or endovascularly administering a rAAV encoding a gene product associated with the disease, e.g., a mammal in which the gene product is absent or present at a reduced level relative to a mammal without the disease. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/212516 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) Original (OR) Class A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 999/99 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346474 | Zhang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ming Zhang (Chicago, Illinois) |
| ABSTRACT | The present invention provides compositions, methods, and systems for treating inflammatory conditions (e.g., by inhibiting reactive oxygen species) in or on a subject with maspin, maspin derivatives, or maspin mimetics. In some embodiments, such agents are applied to the skin of a subject (e.g., to reduce skin aging). |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/383597 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/64 (20130101) A61K 9/0014 (20130101) A61K 38/57 (20130101) Original (OR) Class A61K 2800/782 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 19/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346480 | DISIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (SEATTLE, Washington) |
| INVENTOR(S) | Mary L. DISIS (RENTON, Washington); Denise CECIL (SHORELINE, Washington); Meredith SLOTA (SEATTLE, Washington) |
| ABSTRACT | The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/304823 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/00115 (20180801) A61K 39/001103 (20180801) A61K 39/001106 (20180801) A61K 39/001129 (20180801) A61K 39/001152 (20180801) A61K 48/00 (20130101) A61K 2039/53 (20130101) A61K 2039/572 (20130101) Peptides C07K 14/71 (20130101) C07K 14/705 (20130101) C07K 14/4702 (20130101) C07K 14/70567 (20130101) C07K 14/70596 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/104 (20130101) Enzymes C12Y 203/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346495 | ESSER-KAHN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| INVENTOR(S) | Aaron ESSER-KAHN (Chicago, Illinois); Brittany MOSER (Chicago, Illinois) |
| ABSTRACT | The current disclosure describes the use of NFkB inhibitors as immune potentiators in vaccine compositions comprising adjuvants. Accordingly, aspects of the disclosure relate to a method for vaccinating a subject comprising administering a NFkB inhibitor and an adjuvant (or a composition of the disclosure comprising NFkB and an adjuvant) to the subject. Further aspects relate to a method for inhibiting an inflammatory reaction associated with an adjuvant in a subject, the method comprising co-administering a NFkB inhibitor and an adjuvant (or a composition of the disclosure comprising NFkB and an adjuvant) to the subject. Yet further aspects relate to a pharmaceutical composition comprising a NFkB inhibitor and an adjuvant. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337610 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/09 (20130101) A61K 31/085 (20130101) A61K 31/165 (20130101) A61K 38/1825 (20130101) A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 39/145 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 31/12 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346496 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PDS BIOTECHNOLOGY CORPORATION (North Brunswick, New Jersey); THE GOVERNMENT OF THE USA AS REPRESENTED BY THE SEC. OF THE DEPT. OF HEALTH AND HUMAN SERVICES (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenya Johnson (Mason, Ohio); Eric Jacobson (Cincinnati, Ohio); Frank Bedu-Addo (Bethel, Connecticut); Mikayel Mkrtichyan (Rockville, Maryland); Samir N. Khleif (Silver Spring, Maryland) |
| ABSTRACT | The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one therapeutic factor. The disclosure also provides methods of reducing an immune suppressor cell population in a mammal, methods of augmenting an immune response in a mammal, and methods of treating diseases in a mammal utilizing the vaccine compositions. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/382446 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0005 (20130101) A61K 39/0011 (20130101) A61K 39/12 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 2039/585 (20130101) A61K 2039/55511 (20130101) A61K 2039/55516 (20130101) A61K 2039/55522 (20130101) A61K 2039/55555 (20130101) A61K 2039/55566 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2710/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346499 | THYAGARAJAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baskaran THYAGARAJAN (Laramie, Wyoming); Padmamalini BASKARAN (Laramie, Wyoming) |
| ABSTRACT | A magnetic nanoparticle including a TRPV1 agonist, as well as methods of preparation and use, are described herein. A magnetically responsive pharmaceutical can include a core region having a magnetic nanoparticle (MNPs) and a TRPV1 protein agonist. Further, an exterior coating comprising a polymer can be formed around the core region. The magnetically responsive pharmaceutical can be administered to a recipient and directed to a target region using an external magnetic field. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/384958 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 9/5031 (20130101) A61K 9/5094 (20130101) A61K 9/5153 (20130101) A61K 31/23 (20130101) A61K 31/165 (20130101) A61K 31/231 (20130101) A61K 31/357 (20130101) A61K 31/7034 (20130101) A61K 41/00 (20130101) Original (OR) Class A61K 41/0052 (20130101) A61K 47/02 (20130101) A61K 47/6941 (20170801) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346511 | Goldenberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | Immunomedics, Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David M. Goldenberg (Mendham, New Jersey); Serengulam V. Govindan (SUmmit, New Jersey); Sung-Ju Moon (New Providence, New Jersey) |
| ABSTRACT | The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236709 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4745 (20130101) A61K 45/06 (20130101) A61K 47/6803 (20170801) Original (OR) Class A61K 47/6841 (20170801) A61K 47/6849 (20170801) A61K 47/6851 (20170801) A61K 47/6853 (20170801) A61K 47/6855 (20170801) A61K 47/6857 (20170801) A61K 47/6861 (20170801) A61K 47/6889 (20170801) A61K 2039/505 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Heterocyclic Compounds C07D 491/22 (20130101) Peptides C07K 16/18 (20130101) C07K 16/30 (20130101) C07K 16/303 (20130101) C07K 16/1063 (20130101) C07K 16/2803 (20130101) C07K 16/2833 (20130101) C07K 16/2863 (20130101) C07K 16/2887 (20130101) C07K 16/3046 (20130101) C07K 16/3076 (20130101) C07K 16/3092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346518 | LAM et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kit S. LAM (Davis, California); Lu ZHANG (Sacramento, California) |
| ABSTRACT | The present invention provides a cyanine modified telodendrimer, nanoparticles thereof, and methods of using the nanoparticles to treat various diseases such as cancer. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 17/272021 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 9/5192 (20130101) A61K 31/704 (20130101) A61K 31/4745 (20130101) A61K 41/0057 (20130101) A61K 47/554 (20170801) A61K 47/6885 (20170801) A61K 47/6935 (20170801) Original (OR) Class A61K 49/0034 (20130101) A61K 49/0093 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) A61N 2005/0659 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/33396 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346581 | WU et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongjun WU (Marriottsville, Maryland); Bartley P. GRIFFITH (Gibson Island, Maryland) |
| ABSTRACT | A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380319 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/1629 (20140204) A61M 1/1698 (20130101) Original (OR) Class A61M 60/00 (20210101) A61M 60/113 (20210101) A61M 60/205 (20210101) A61M 2205/3334 (20130101) A61M 2205/3368 (20130101) A61M 2206/10 (20130101) A61M 2209/088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346602 | PATEK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| INVENTOR(S) | Stephen D. PATEK (Charlottesville, Virginia); Basak OZASLAN (Charlottesville, Virginia); Linda GONDER-FREDERICK (Charlottesville, Virginia) |
| ABSTRACT | An insulin device configured to control insulin dispensing based on insulin sensitivity. The insulin device includes a processor configured to receive insulin dosing schedule information, psychological stress level data, and body mass index (BMI) data; a sensor configured to generate a blood glucose level measurement. The sensor is calibrated as a function of the psychological stress level data and the BMI data and the processor is configured to monitor and detect changes of the blood glucose level measurement that are determined to have occurred as a function of changes of the psychological stress level data, and identify a time when the BMI data counteracts a detected change in the blood glucose level measurement. The insulin device also includes an insulin dispensing valve controlled by the processor to change the insulin dosing schedule information in accordance with the counteracting BMI data. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 17/373998 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 5/14276 (20130101) A61M 2205/3553 (20130101) A61M 2205/3569 (20130101) A61M 2205/3584 (20130101) A61M 2230/201 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/17 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346699 | Miocinovic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Svjetlana Miocinovic (Atlanta, Georgia); Babak Mahmoudi (Atlanta, Georgia); Parisa Sarikhani (Decatur, Georgia) |
| ABSTRACT | The disclosures relates to systems and methods for automatically determining a patient-specific set of stimulation parameters using optimization for exploring and/or programming a neurostimulation device, e.g., deep brain stimulation (DBS). In one implementation, the method may include receiving patient data and set of stimulation parameters associated stimulation delivered to a patient by a neurostimulation device. The method may include determining one or more objective metrics using the patient data for each set of stimulation parameters. The one or more objective metrics may be a quantitative value that represents a rating or score of tremor severity and/or ide effect severity associated. The method may further include generating a patient specific response model using the one or more objective metrics and the associated set of stimulation parameters. The method may also include applying an optimization algorithm to the generated response model to determine a candidate set of one or more stimulation parameters. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/315129 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0534 (20130101) A61N 1/36067 (20130101) Original (OR) Class A61N 1/36175 (20130101) A61N 1/36178 (20130101) A61N 1/36192 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346726 | Kiani |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mehdi Kiani (State College, Pennsylvania) |
| ABSTRACT | A method and system of neural stimulation and imaging of nervous system of a subject. The method includes the steps of providing an interface device operable to generate an ultrasonic beam for neuroniodulation and imaging of a targeted neural structure of a subject, implanting the interface device in the subject, and providing and disposing an external coil array over the targeted neural structure of the subject, wherein the external coil array is wirelessly powering and communicating with the interface device. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/283983 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0534 (20130101) A61N 1/37223 (20130101) A61N 1/37235 (20130101) A61N 7/00 (20130101) Original (OR) Class A61N 2007/0026 (20130101) A61N 2007/0052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346844 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jongyoon Han (Bedford, Massachusetts); Hyuckjin Kwon (Somerville, Massachusetts) |
| ABSTRACT | The invention is directed to a scalable concentration device and method of use thereof based on electrokinetics. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/191842 |
| CURRENT CPC | Separation B01D 61/485 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) G01N 33/48707 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346888 | Abate et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam R. Abate (Daly City, California); Iain Clark (San Francisco, California) |
| ABSTRACT | The methods described herein provide an improved approach for generating monodispersed droplets. Monodispersed droplets may be effectively obtained by using a plurality of particles to trigger the breakup of a jet, which can include, e.g., flowing in a channel of a microfluidic device a first fluid into a second fluid under stable jetting conditions to provide a jet of the first fluid in the second fluid, wherein the first fluid is immiscible with the second fluid; and introducing a plurality of particles into the jet of the first fluid triggering break-up of the jet of the first fluid and encapsulation of the plurality of particles in a plurality of monodispersed droplets of the first fluid in the second fluid. |
| FILED | Thursday, August 15, 2019 |
| APPL NO | 17/266911 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 3/0811 (20130101) B01F 13/0062 (20130101) B01F 2003/0842 (20130101) B01F 2003/0846 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347709 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Kai Chen (Los Angeles, California); Peter S. CONTI (Los Angeles, California) |
| ABSTRACT | The invention provides a radiopharmaceutical compound or composition comprising a radiolabeled linear peptide that binds specifically to Glypican-3 (GPC3) expressed on a surface of a cell. Preferably, the linear peptide is conjugated to one or more 18F atoms. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245938 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/1093 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/002 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/534 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347734 | Mallipattu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); Icahn School of Medicine at Mount Sinai (New York, New York); The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sandeep Mallipattu (St. James, New York); Bhaskar Das (West Nyack, New York) |
| ABSTRACT | The present disclosure is concerned with small molecule modulators of KLF15 signaling useful for treating various disorders such as, for example, kidney disease (e.g., chronic kidney disease), heart disease, obesity, or a neurodegenerative disorder (e.g., amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD)). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244762 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/573 (20130101) Acyclic or Carbocyclic Compounds C07C 321/20 (20130101) Heterocyclic Compounds C07D 213/74 (20130101) C07D 213/85 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347742 | Verkman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan S. Verkman (San Francisco, California); Marc H. Levin (San Francisco, California); Onur Cil (San Francisco, California); Mark J. Kurth (Davis, California) |
| ABSTRACT | Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders, and other diseases and disorders. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/226004 |
| CURRENT CPC | Heterocyclic Compounds C07D 241/44 (20130101) Original (OR) Class C07D 401/06 (20130101) C07D 403/04 (20130101) C07D 405/04 (20130101) C07D 405/06 (20130101) C07D 409/04 (20130101) C07D 409/06 (20130101) C07D 498/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347761 | Buhrlage et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sara Buhrlage (Somerville, Massachusetts); Xiaoxi Liu (Burlington, Massachusetts) |
| ABSTRACT | Disclosed herein are inhibitors of deubiquitinating (DUB) enzyme USP7 (Ubiquitin Specific Protease 7). Also provided are methods of treating a disease or disorder modulated by USP7. |
| FILED | Tuesday, October 22, 2019 |
| APPL NO | 17/286219 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/06 (20130101) C07D 401/14 (20130101) Original (OR) Class C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347804 | Ziegler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Ray Ziegler (State College, Pennsylvania); Joshua David Lambert (State College, Pennsylvania); Rachel Marie Shegog (State College, Pennsylvania); Emmanouil Chatzakis (State College, Pennsylvania); Deepti Dabas (Portage, Michigan) |
| ABSTRACT | The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange or yellow. The invention also provides compositions and methods for coloring edible materials to a desired color such as red, orange or yellow. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/301711 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 5/42 (20160801) A23L 5/47 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/26 (20130101) Original (OR) Class Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 61/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347811 | LITTMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan R. LITTMAN (New York, New York); Jun R. HUH (Newton, Massachusetts); Michael FISCHBACH (Stanford, California) |
| ABSTRACT | Steroid compounds are disclosed that have a formula represented by the following: (I) and wherein R1, R2, R3a, R3b, R4a, R4b, R5, R6a, R6b, R7, R8, and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for promoting differentiation of T regulatory (Treg) lymphocytes, and for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, and graft-versus-host disease. |
| FILED | Tuesday, October 08, 2019 |
| APPL NO | 17/284227 |
| CURRENT CPC | Steroids C07J 9/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2501/15 (20130101) C12N 2501/999 (20130101) C12N 2501/2302 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347824 | Van de Water et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Judy Van de Water (Capay, California); Elizabeth Edmiston (Sacramento, California) |
| ABSTRACT | The present invention provides peptides that specifically bind to maternal autoantibodies that are generated in the mother or potential mother against one or more endogenous polypeptide antigens selected from lactate dehydrogenase A (LDH A), lactate dehydrogenase B (LDH B), stress-induced phosphoprotein 1 (STIP1), guanine deaminase (GDA), Y Box Binding Protein 1 (YBX1), collapsin response mediator protein 1 (CRMP1), and collapsin response mediator protein 2 (CRMP2). The peptides described herein are useful for determining a risk of an offspring for developing an autism spectrum disorder (ASD) by detecting the presence of maternal autoantibodies in a biological sample of the mother or potential mother. The peptides or mimotopes thereof can also be administered to the mother or potential mother to block the binding between maternal autoantibodies and their antigens, thereby neutralizing the maternal autoantibodies. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/378401 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Peptides C07K 7/08 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 2800/28 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347847 | Regev et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aviv Regev (Cambridge, Massachusetts); Benjamin Izar (Boston, Massachusetts) |
| ABSTRACT | The present invention provides for methods and compositions for treating cancer. Disclosed are novel tumor biomarkers and therapeutic targets. Also disclosed are CAR T cells targeting tumor specific surface proteins. Also disclosed are shared expression programs specific to tumor cells. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317772 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) A61K 47/6849 (20170801) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 16/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/78 (20130101) C12N 15/111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347851 | Isaacs et al. |
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| FUNDED BY |
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| APPLICANT(S) | Novartis AG (Basel, Switzerland); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Randi Isaacs (Basking Ridge, New Jersey); Noelle Frey (Philadelphia, Pennsylvania); David L. Porter (Springfield, Pennsylvania) |
| ABSTRACT | The invention provides compositions and methods for treating cancer, e.g., hematological cancer, by administering a CD19 CAR-expressing cell as described herein, in combination with a CD22 CAR-expressing cell as described herein. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 17/280467 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 14/70596 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347864 | CROWE, Jr. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee) |
| ABSTRACT | The present disclosure is directed to antibodies binding to and neutralizing Zika virus and methods for use thereof. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/321732 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1081 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347881 | CHUGH |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RUSH UNIVERSITY MEDICAL CENTER (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sumant Singh CHUGH (Oak Park, Illinois) |
| ABSTRACT | Described herein are methods for inhibiting the acute relapse or worsening of glomerular disease in response to viral infections associated with the common cold or flu comprising administration of anti-cytokine antibodies, anti-receptor antibodies, soluble receptors, or blocking agents to a subject in need thereof. Also described are methods for depleting a subjects systemic levels of one or more of cytokines IL-2, IL-6, IL-10, INF-γ, or TNFα, or inhibiting the receptors IL-4R or ICAM-1 comprising contacting the cytokines or receptors with one or more anti-cytokine antibodies, anti-receptor antibodies, soluble receptors, or blocking agents. |
| FILED | Monday, July 22, 2019 |
| APPL NO | 17/262625 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1793 (20130101) A61K 45/06 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/02 (20180101) Peptides C07K 16/241 (20130101) C07K 16/246 (20130101) Original (OR) Class C07K 16/248 (20130101) C07K 16/2821 (20130101) C07K 16/2866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347882 | Johns |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger A. Johns (Reisterstown, Maryland) |
| ABSTRACT | The present invention relates to the field of pulmonary, cardiac and inflammatory disorders. More specifically, the present invention provides methods and compositions for treating disorders associated with Resistin. In a specific embodiment, the present invention provides an antibody that binds human Resistin. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/077433 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/08 (20180101) A61P 9/10 (20180101) Peptides C07K 14/575 (20130101) C07K 16/26 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347884 | KIMBERLY |
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| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | William Taylor KIMBERLY (Belmont, Massachusetts) |
| ABSTRACT | Disclosed herein are methods and compositions for the treatment of a brain injury. The method involves administering to a subject who has had a brain injury an agent that inhibits sST2, or an agent that upmodulates IL-33. Methods for preventing a poor functional prognosis, as well as identifying a subject at risk of a poor functional prognosis following a brain injury are also provided herein. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/197380 |
| CURRENT CPC | Peptides C07K 16/28 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2800/52 (20130101) G01N 2800/2871 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347885 | Lai et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); MUCOMMUNE, LLC (Carrboro, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Lai (Carrboro, North Carolina); Bhawana Shrestha (Carrboro, North Carolina); Alison Schaefer (Chape! Hill, North Carolina); Timothy Jacobs (Durham, North Carolina); Thomas Moench (Baltimore, Maryland) |
| ABSTRACT | Synthetic binding agents for reducing the fraction of targets that can permeate through mucus and/or freely divide, and methods of reducing mucosal permeation and/or free division of a target using these synthetic binding agents. |
| FILED | Monday, September 23, 2019 |
| APPL NO | 17/278217 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/16 (20180101) A61P 31/04 (20180101) Peptides C07K 16/28 (20130101) Original (OR) Class C07K 16/1217 (20130101) C07K 16/1228 (20130101) C07K 16/1235 (20130101) C07K 2317/51 (20130101) C07K 2317/52 (20130101) C07K 2317/55 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347887 | Blumberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Richard S. Blumberg (Waltham, Massachusetts); Kristi Baker (Brookline, Massachusetts); Timo Rath (Cambridge, Massachusetts) |
| ABSTRACT | Described herein are compositions for increasing IL-12 production comprising IgG or a fragment thereof or a variant thereof and uses of said compositions for treating cancer and infectious diseases. Also described herein are compositions for decreasing IL-12 production comprising an agent that inhibits signaling mediated by interaction between FcRn and IgG and uses of said compositions for treating autoimmune diseases. Further described herein are methods for assessing efficacy of treatment by monitoring levels of various cytokines in the subject. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196451 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 2039/505 (20130101) A61K 2039/507 (20130101) Peptides C07K 16/00 (20130101) C07K 16/244 (20130101) C07K 16/283 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/31 (20130101) C07K 2317/52 (20130101) C07K 2317/72 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 33/574 (20130101) G01N 33/6854 (20130101) G01N 33/6863 (20130101) G01N 33/6866 (20130101) G01N 33/6869 (20130101) G01N 2333/57 (20130101) G01N 2333/525 (20130101) G01N 2333/5434 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347918 | Schoenfisch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark H. Schoenfisch (Chapel Hill, North Carolina); Mona Jasmine R. Ahonen (Chapel Hill, North Carolina); Dakota J. Suchyta (Chapel Hill, North Carolina); Kaitlyn Rose Rouillard (Durham, North Carolina) |
| ABSTRACT | Large molecular weight alginates which are covalently modified to store and release nitric oxide, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates may be tailored to release nitric oxide in a controlled manner and are useful for eradication of both planktonic and biofilm-based bacteria. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/385497 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 65/03 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/734 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/12 (20180101) A61P 31/04 (20180101) Polysaccharides; Derivatives Thereof C08B 37/0084 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348107 | KIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (Seoul, South Korea) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (Seoul, South Korea) |
| INVENTOR(S) | Deok-Ho KIM (Seattle, Washington); Byung-Ok CHOI (Seattle, Washington); Alexander S.T. SMITH (Seattle, Washington) |
| ABSTRACT | The technology described herein is directed to devices, systems, methods, and assays comprising electrode arrays for electroconductive cells. In particular, the technology generally relates to a microelectrode array (MEA) device comprising both field potential (FP) electrodes and impedance electrodes (IE) that are spatially separated for the functional analysis of the electrical connectivity between at least two cell populations, for example a plurality of neuronal cells and a plurality of contractile cells. |
| FILED | Thursday, September 19, 2019 |
| APPL NO | 17/277641 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 35/02 (20130101) Original (OR) Class C12M 41/46 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/4836 (20130101) G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348119 | SINGEC et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America as Represented By The Secretary of the Departmen of Health and Human (Rockville, Maryland) |
| ASSIGNEE(S) | The United States of America as Represented By The Secretary of The Department of Health and Human (Rockville, Maryland) |
| INVENTOR(S) | Ilyas SINGEC (Rockville, Maryland); Yu CHEN (Rockville, Maryland); Anton SIMEONOV (Rockville, Maryland) |
| ABSTRACT | Compositions and methods useful for culturing mammalian cells, tissues and/or organs are provided. The compositions contain Chroman 1 or its derivatives, may further include Emricasan or its derivatives, and may further include one or both of trans-ISRIB and polyamines. The compositions may be formulated as media additives, media concentrates or working media. The compositions and methods may be used to culture stem cells, progenitor cells, differentiated cells, isolated primary cells, secondary cells, immortalized cells, cell line cells, germline cells, somatic cells, or modified cells, including genetically modified cells. The compositions and methods may be used to culture, preserve or maintain cells, tissues, organs parts or organs, grow embryoid bodies, embryos, organs or organ parts. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/284215 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) Original (OR) Class C12N 2501/999 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348123 | Boehm et al. |
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| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manfred Boehm (Bethesda, Maryland); Guibin Chen (Ellicott City, Maryland); Mahendra Rao (Timonium, Maryland); Andre Larochelle (Bethesda, Maryland) |
| ABSTRACT | Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derided cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells. The described cells include iPSC-derived mesodermal precursor cells (MPC), which itself may differentiate into at least four different cell types. When cultured under appropriate conditions, the mesodermal precursor cells can be used to produce hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), smooth muscle cells (SMC), or unlimited functional endothelial cells (UFEC). One characteristic that makes the described cells desirable is that they can be maintained in culture for a number of days, or passages, without changing phenotype through differentiation. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337978 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 5/0607 (20130101) Original (OR) Class C12N 5/0647 (20130101) C12N 5/0661 (20130101) C12N 5/0662 (20130101) C12N 5/0696 (20130101) C12N 2500/05 (20130101) C12N 2500/30 (20130101) C12N 2500/36 (20130101) C12N 2500/42 (20130101) C12N 2500/44 (20130101) C12N 2500/90 (20130101) C12N 2501/26 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) C12N 2501/165 (20130101) C12N 2506/03 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348127 | Leen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ann Marie Leen (Houston, Texas); Juan Fernando Vera Valdes (Bellaire, Texas); Cliona M. Rooney (Houston, Texas); Ulrike Gerdemann (Cambridge, Massachusetts) |
| ABSTRACT | The present invention concerns methods of generating CTLs that are able to target at least one antigen from two or more viruses. The method includes exposing mixtures of peptides for different antigens to the same plurality of PBMCs and, at least in certain aspects, expanding the cells in the presence of IL4 and IL7. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/443261 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) Original (OR) Class C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348142 | Barnes et al. |
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| FUNDED BY |
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| APPLICANT(S) | DNA POLYMERASE TECHNOLOGY, INC. (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne M. Barnes (University City, Missouri); Milko B. Kermekchiev (St. Louis, Missouri); Zhian Zhang (Ballwin, Missouri) |
| ABSTRACT | Provided are mutant polymerases having DNA polymerase activity and reverse transcriptase activity or strand displacement activity, along with target nucleic acid amplification methods employing such mutant polymerases. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/303445 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) Original (OR) Class C12N 9/1276 (20130101) C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6846 (20130101) C12Q 2521/101 (20130101) C12Q 2531/101 (20130101) C12Q 2531/119 (20130101) Enzymes C12Y 207/07007 (20130101) C12Y 207/07049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348146 | Fischetti et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE ROCKEFELLER UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent A. Fischetti (New York, New York); Anu Daniel (New York, New York); Chad Euler (New York, New York) |
| ABSTRACT | The present description relates to chimeric bacteriophage lysins useful for the identification and/or reduction of staphylococcal populations. For example, a chimeric bacteriophage lysin was engineered and shown to effectively kill all strains of staphylococci tested including antibiotic resistant methicillin-resistant S. Aureus and VISA. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/328299 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/00 (20130101) A01N 63/50 (20200101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2462 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348156 | Koonin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Rutgers, The State University of New Jersey (New Brunswick, New Jersey); Skolkovo Institute of Science and Technology (Moscow, Russian Federation); The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Koonin (Bethesda, Maryland); Feng Zhang (Cambridge, Massachusetts); Yuri I. Wolf (Bethesda, Maryland); Sergey Shmakov (Moscow, Russian Federation); Konstantin Severinov (New Brunswick, New Jersey); Ekaterina Semenova (New Brunswick, New Jersey); Leonid Minakhin (New Brunswick, Maryland); Kira S. Makarova (Bethesda, Maryland); Silvana Konermann (Cambridge, Massachusetts); Julia Joung (Cambridge, Massachusetts); Jonathan S. Gootenberg (Cambridge, Massachusetts); Omar O. Abudayyeh (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/246460 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/8213 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348157 | Koonin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts); Rutgers, The State University of New Jersey (New Brunswick, New Jersey); Skolkovo Institute of Science and Technology (Moscow, Russian Federation); The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Koonin (Bethesda, Maryland); Feng Zhang (Cambridge, Massachusetts); Yuri I. Wolf (Bethesda, Maryland); Sergey Shmakov (Moscow, Russian Federation); Konstantin Severinov (New Brunswick, New Jersey); Ekaterina Semenova (New Brunswick, New Jersey); Leonid Minakhin (New Brunswick, Maryland); Kira S. Makarova (Bethesda, Maryland); Silvana Konermann (Cambridge, Massachusetts); Julia Joung (Cambridge, Massachusetts); Jonathan S. Gootenberg (Cambridge, Massachusetts); Omar O. Abudayyeh (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/246466 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/8213 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348160 | NAKAI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hiroyuki NAKAI (Portland, Oregon); Samuel HUANG (Portland, Oregon); Kei ADACHI (Portland, Oregon) |
| ABSTRACT | Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/337341 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2310/11 (20130101) C12N 2320/33 (20130101) C12N 2750/14123 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348164 | Ambati et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); University of Kentucky Research Foundation (Lexington, Kentucky) |
| INVENTOR(S) | Jayakrishna Ambati (Charlottesville, Virginia); Bradley David Unti Gelfand (Charlottesville, Virginia); Nagaraj Kerur (Crozet, Virginia); Shinichi Fukuda (Charlottesville, Virginia); Kameshwari Ambati (Charlottesville, Virginia); Benjamin Fowler (Miami, Florida) |
| ABSTRACT | Provided are method for treating age-related macular degeneration (AGE), and/or preventing the occurrence or progression thereof in a subject in need thereof. In some embodiments, the methods include administering to the subject in need thereof a composition that has an effective amount of an inhibitor of reverse transcriptase (RTase) activity. Also provided are methods for protecting retinal pigmented epithelium (RPE) cells, retinal photoreceptor cells, and/or choroidal cells; methods for treating geographic atrophy of the eye, and/or for preventing occurrence or progression thereof; and pharmaceutical compositions for treating AGE and/or GA and/or for preventing the occurrence or progression thereof; and/or for protecting RPE cells, retinal photoreceptor cells, and/or choroidal cells. |
| FILED | Wednesday, October 09, 2019 |
| APPL NO | 17/283626 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/536 (20130101) A61K 47/543 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 16/18 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348168 | Daugherty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan Daugherty (Lexington, Kentucky); Hong Lu (Lexington, Kentucky); Mary Sheppard (Lexington, Kentucky); Jeff Chen (Lexington, Kentucky) |
| ABSTRACT | Disclosed herein is a method for attenuating aortic pathology in a subject having Marfan syndrome by reducing angiotensinogen plasma levels in the subject. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308895 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4178 (20130101) A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1136 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/351 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348171 | Ong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington); Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| INVENTOR(S) | Shao-En Ong (Seattle, Washington); Martin Golkowski (Seattle, Washington); Ho-Tak Lau (Seattle, Washington); Taranjit S. Gujral (Seattle, Washington) |
| ABSTRACT | The disclosure provides methods and compositions for increasing sensitivity, or decreasing resistance, of cancer cells to chemotherapeutic agents such as kinase inhibitor agents. In some embodiments, the cancer cells are hepatocellular carcinoma (HCC) cells. The methods and compositions can be integrated into methods of treatment of a subject with cancer, which can further comprise administering a chemotherapeutic agent such as kinase inhibitor agents. In another aspect, the disclosure provides a method for profiling the kinome of a cell or group of similar cells that incorporates kinase capture reagents and mass spectrometry analysis. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313512 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 31/455 (20130101) A61K 31/7088 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/22 (20130101) C07K 16/2827 (20130101) C07K 16/2863 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348190 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guangping Gao (Westborough, Massachusetts); James M. Wilson (Philadelphia, Pennsylvania); Mauricio R. Alvira (Philadelphia, Pennsylvania) |
| ABSTRACT | Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/145844 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/761 (20130101) A61K 38/45 (20130101) A61K 38/177 (20130101) A61K 38/4846 (20130101) A61K 48/00 (20130101) Peptides C07K 14/005 (20130101) C07K 14/705 (20130101) C07K 14/755 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/644 (20130101) C12N 9/1018 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 15/8645 (20130101) Enzymes C12Y 304/21021 (20130101) C12Y 304/21022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348195 | Ting et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Allen Institute (Seattle, Washington); Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | Allen Institute (Seattle, Washington); Seattle Children's Hospital d/b/a Seattle Children's Research Institute (Seattle, Washington) |
| INVENTOR(S) | Jonathan Ting (Lake Forest Park, Washington); Boaz P. Levi (Seattle, Washington); John K. Mich (Seattle, Washington); Edward Sebastian Lein (Mercer Island, Washington); Franck Kalume (Bothell, Washington) |
| ABSTRACT | Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in GABAergic interneurons. |
| FILED | Thursday, October 03, 2019 |
| APPL NO | 17/283232 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0278 (20130101) A01K 2217/052 (20130101) A01K 2227/105 (20130101) A01K 2227/106 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2510/00 (20130101) C12N 2750/14043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348196 | PATTNAIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bikash PATTNAIK (Middleton, Wisconsin); Pawan SHAHI (Madison, Wisconsin) |
| ABSTRACT | The present invention is directed to gene therapy constructs and pharmaceutical compositions for the expression of Kir7.1. The gene therapy constructs include a vector comprising a promoter operably connected to a polynucleotide encoding a Kir7.1 polypeptide. Methods of treating a subject having a condition associated with insufficient expression or function of a Kir7.1 polypeptide are also provided. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 17/284408 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 48/00 (20130101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348207 | Weiss et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Weiss (Decatur, Georgia); Victor Band (Decatur, Georgia); David Hufnagel (Atlanta, Georgia) |
| ABSTRACT | This disclosure contemplates detecting antimicrobial heteroresistance to guide antibiotic or other antimicrobial therapy. In certain embodiments, this disclosure contemplates avoiding a monotherapy with antibiotics to which an individual bacterial pie isolate is heteroresistant, because this can lead to treatment failure. Thus, in certain embodiments, one uses a combination of antibiotics to which a bacterium is individually heteroresistant. |
| FILED | Monday, September 23, 2019 |
| APPL NO | 17/277857 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348212 | Fozouni et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Parinaz Fozouni (San Francisco, California); Melanie Ott (Mill Valley, California); Jennifer A. Doudna (Oakland, California) |
| ABSTRACT | The present disclosure relates to methods using CRISPR-Cas13a enzyme, complexed with HIV or HCV crRNAs to specifically and sensitively detect and quantify the presence of HIV or HCV RNA in a sample. These methods can be used to diagnose HIV or HCV infection, quantify the concentration of HIV or HCV RNA present in a sample, identify the presence of different HIV or HCV splice variants, subtypes, or mutations, and to monitor reactivation of HIV or HCV transcription. |
| FILED | Friday, September 06, 2019 |
| APPL NO | 17/273752 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/703 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6888 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348217 | RODRIQUES et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); BROAD INSTITUTE, INC (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Gordon RODRIQUES (Cambridge, Massachusetts); Edward BOYDEN (Chestnut Hill, Massachusetts); Fei CHEN (Cambridge, Massachusetts); Linlin CHEN (Cambridge, Massachusetts); Sophia LIU (Roxbury, Massachusetts); Ellen ZHONG (Cambridge, Massachusetts); Joseph SCHERRER (Boston, Massachusetts) |
| ABSTRACT | The invention, in some aspects, includes systems, methods and components of molecular recorders that encode the timing of transcriptional activity into the sequence of RNA, which can then enable a sequencing-based readout of the internal dynamics of cells. |
| FILED | Tuesday, July 16, 2019 |
| APPL NO | 17/150620 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/78 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6811 (20130101) Original (OR) Class Enzymes C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348226 | Kaur et al. |
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| FUNDED BY |
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| APPLICANT(S) | BASE PAIR BIOTECHNOLOGIES, INC. (Pearland, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jasmine Kaur (Pearland, Texas); Rafal Drabek (Houston, Texas); George W. Jackson (Pearland, Texas); Robert Batchelor (Pearland, Texas); Alexander Chiu (Pearland, Texas) |
| ABSTRACT | The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as opioids and opioid derivatives. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152007 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) C12N 15/1048 (20130101) C12N 2310/16 (20130101) C12N 2330/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6837 (20130101) C12Q 1/6848 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 1/6876 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348230 | Walter et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nils Walter (Ann Arbor, Michigan); Muneesh Tewari (Ann Arbor, Michigan); Alexander Johnson-Buck (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein is technology relating to detecting and identifying nucleic acids and particularly, but not exclusively, to compositions, methods, kits, and systems for detecting, identifying, and quantifying target nucleic acids with high confidence at single-molecule resolution. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319289 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6832 (20130101) C12Q 1/6834 (20130101) C12Q 1/6876 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348233 | Khatri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Purvesh Khatri (Menlo Park, California); Timothy E. Sweeney (San Francisco, California) |
| ABSTRACT | Methods for diagnosis of tuberculosis are disclosed. In particular, the invention relates to the use of a panel of biomarkers for aiding diagnosis, prognosis, and treatment of tuberculosis. The identified biomarkers can be used to detect active tuberculosis as well as to distinguish active tuberculosis from latent tuberculosis and other pulmonary and infectious diseases, and for monitoring responses to treatment. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/146294 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/56 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348234 | MOOTHA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Venkateswara Vinod MOOTHA (Coppell, Texas); David R. COREY (Dallas, Texas); Jiaxin HU (Coppell, Texas); Yongjun CHU (Dallas, Texas) |
| ABSTRACT | Molecular biomarkers relating to Fuchs' endothelial corneal dystrophy (FECD), glaucoma, and other degenerative ocular diseases are provided, as well as methods for using such biomarkers methods of treatment. These biomarkers may be used to monitor the progression of FECD, glaucoma, or other degenerative ocular diseases. Furthermore, these biomarkers may be used to monitor the treatment of FECD, glaucoma, or other degenerative ocular diseases. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184360 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348243 | Ott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads (San Francisco, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melanie Ott (Mill Valley, California); Parinaz Fozouni (San Francisco, California); Jennifer A. Doudna (Oakland, California); Daniel A. Fletcher (Berkeley, California); David Savage (Berkeley, California); Emeric Charles (Berkeley, California); Sungmin Son (Oakland, California); Gagandeep Renuka Kumar (San Francisco, California); Neil Switz (Oakland, California) |
| ABSTRACT | The present disclosure relates to methods using CRISPR-Cas13 enzyme, complexed with SARS-CoV-2 crRNA guide RNAs to detect and quantify the presence of SARS-CoV-2 RNA in a sample with enhanced specificity and sensitivity. These methods can be used to diagnose SARS-CoV-2 infection, quantify the concentration of SARS-CoV-2 RNA present in a sample, identify the presence of different SARS-CoV-2 splice variants, subtypes, or mutations, and to monitor reactivation of SARS-CoV-2 transcription. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/206020 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6825 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348991 | Chung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Kwanghun Chung (Lexington, Massachusetts); Taeyun Ku (Seoul, South Korea) |
| ABSTRACT | Provided herein are compositions, methods of making, and methods of use relating to reversibly compressible tissue-hydrogel hybrids. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308462 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349012 | Styczynski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Styczynski (Atlanta, Georgia); Monica P. McNerney (Atlanta, Georgia) |
| ABSTRACT | Disclosed herein are systems and methods for quantifying analytes in a desired complex solution with minimal inter-sample variability. The invention includes methods and diagnostic tools for quantifying analytes in aqueous solutions or biological fluid samples with sample-specific calibration and colorimetric or detectable output. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 17/273728 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) G01N 21/272 (20130101) Original (OR) Class G01N 33/52 (20130101) G01N 33/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349078 | VALDEZ |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregorio VALDEZ (Barrington, Rhode Island) |
| ABSTRACT | The invention provides molecular tools to visualize, isolate, and manipulate the glial cells that are necessary for the formation, stability, and function of the synapse. The inventors identified a unique gene expression signature that distinguishes perisynaptic Schwann cells from all other Schwann cells. Using a combinatorial approach and coëxpressing two different fluorescence proteins, each using a different promoter, only those glial cells associated with the neuromuscular synapse are labeled. |
| FILED | Wednesday, April 21, 2021 |
| APPL NO | 17/236790 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) G01N 33/68 (20130101) G01N 33/5058 (20130101) Original (OR) Class G01N 2015/0065 (20130101) G01N 2333/705 (20130101) G01N 2333/43595 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349088 | JAMES et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oklahoma Medical Research Foundation (Oklahoma City, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Judith Ann JAMES (Edmond, Oklahoma); Melissa E. MUNROE (Edmond, Oklahoma) |
| ABSTRACT | The present invention includes a method of characterizing disease activity in a systemic lupus erythematosus patient (SEE), comprising: obtaining a dataset associated with a blood, serum, plasma or urine sample from the patient, wherein the dataset comprises data representing the level of one or more biomarkers in the blood, serum, plasma or urine sample from each of (b) to (g); at least one innate serum or plasma mediator biomarker; at least one adaptive serum or plasma mediator; at least one chemokine/adhesion molecule biomarker; at least one soluble TNF superfamily biomarker; the inflammatory mediator biomarker SCF; at least one SLE-associated autoantibody specificity biomarker; and calculating a Lupus Disease Activity Immune |
| FILED | Wednesday, September 25, 2019 |
| APPL NO | 17/286221 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 33/6803 (20130101) G01N 2800/104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349094 | Vasu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chenthamarakshan Vasu (Charleston, South Carolina) |
| ABSTRACT | The invention provides a method for detecting an IgA anti-nuclear autoantibody in a fecal sample from a subject, wherein the presence of the IgA anti-nuclear autoantibody is an early indicator of the presence or increased risk of development of an autoimmune disease or disorder. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317057 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) Original (OR) Class G01N 2333/47 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349096 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chengcheng ZHANG (Dallas, Texas); Zhiqiang AN (Houston, Texas); Ningyan ZHANG (Houston, Texas); Mi DENG (Plano, Texas); Jaehyup KIM (Houston, Texas); Xun GUI (Houston, Texas) |
| ABSTRACT | Provided herein are methods and compositions for the identification of modulators of ApoE-induced LILRB activation. Also provided herein are methods of treating cancer comprising the administration of an inhibitor of ApoE-induced LILRB activation. Also provided are methods of treating autoimmune disease or inhibiting the onset of transplant rejection or treating an inflammatory disorder comprising administering an agonist of ApoE-induced LILRB activation to a subject. |
| FILED | Thursday, July 27, 2017 |
| APPL NO | 16/321745 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 21/6428 (20130101) G01N 21/6456 (20130101) G01N 33/5023 (20130101) G01N 33/57426 (20130101) Original (OR) Class G01N 33/57492 (20130101) G01N 2015/0065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349100 | Shao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Jieya Shao (St. Louis, Missouri); Marc Diamond (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides methods to quantify VCP phosphorylation at specific amino acid residue to predict responsiveness of a subject having a cancer or tumor to a genotoxic treatment, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/315061 |
| CURRENT CPC | Peptides C07K 16/40 (20130101) C07K 2317/565 (20130101) Enzymes C12Y 306/04006 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) G01N 33/57496 (20130101) Original (OR) Class G01N 2333/914 (20130101) G01N 2440/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349103 | NEWGARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher B. NEWGARD (Durham, North Carolina); Phillip WHITE (Durham, North Carolina); Thomas GRENIER-LAROUCHE (Durham, North Carolina) |
| ABSTRACT | The present invention relates to biomarkers and methods of using the same. Specifically, the present invention relates to biomarkers for nonalcoholic fatty liver disease and related disease phenotypes and methods of using the same. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 17/254118 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) Original (OR) Class G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349104 | WOHLSTADTER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Meso Scale Technologies, LLC. (Rockville, Maryland); The United States of America,as represented by the Secretary,Department of Health and Human Services (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob N. WOHLSTADTER (Potomac, Maryland); George SIGAL (Rockville, Maryland); Anu MATHEW (North Potomac, Maryland); James WILBUR (Germantown, Maryland); Jeffery DEBAD (Ijamsville, Maryland); Christopher CAMPBELL (Columbia, Maryland); Hans BIEBUYCK (Potomac, Maryland); Priscilla KRAI (Germantown, Maryland); Alan KISHBAUGH (Rockville, Maryland); Leonid DZANTIEV (Ellicott City, Maryland); Christopher SHELBURNE (Rockville, Maryland); Pu LIU (Rockville, Maryland); Paul GOODWIN (Frederick, Maryland); Adrian MCDERMOTT (Bethesda, Maryland); Sarah O'CONNELL (Bethesda, Maryland); Sandeep NARPALA (Bethesda, Maryland) |
| ABSTRACT | The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/246364 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 2333/165 (20130101) G01N 2469/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349167 | WU et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); CEDARS-SINAI MEDICAL CENTER (LOS ANGELES, California) |
| INVENTOR(S) | YIJEN LIN WU (WEXFORD, Pennsylvania); ANTHONY CHRISTODOULOU (LOS ANGELES, California) |
| ABSTRACT | A magnetic resonance imaging method is includes collecting spatially encoded data from a subject using an MRI system, and directly extracting a number of temporal basis functions using at least a first portion of the spatially encoded data. The method further includes, after directly extracting the number of temporal basis functions, iteratively calculating a number of coefficient images using the number of temporal basis functions and at least a second portion of the spatially encoded data. Finally, the method includes generating a 4D image based on the number of temporal basis functions and the number of coefficient images. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245342 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4818 (20130101) G01R 33/5611 (20130101) G01R 33/56308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210350110 | Solanki et al. |
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| FUNDED BY |
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| APPLICANT(S) | EYENUK, INC. (Woodland Hills, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaushal Mohanlal Solanki (Woodland Hills, California); Chaithanya Amai Ramachandra (Woodland Hills, California); Sandeep Bhat Krupakar (Woodland Hills, California) |
| ABSTRACT | Embodiments disclose systems and methods that aid in screening, diagnosis and/or monitoring of medical conditions. The systems and methods may allow, for example, for automated identification and localization of lesions and other anatomical structures from medical data obtained from medical imaging devices, computation of image-based biomarkers including quantification of dynamics of lesions, and/or integration with telemedicine services, programs, or software. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/121739 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/14 (20130101) A61B 3/0025 (20130101) Electric Digital Data Processing G06F 16/51 (20190101) G06F 16/583 (20190101) G06F 16/5866 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0061 (20130101) Original (OR) Class G06K 9/342 (20130101) G06K 9/00597 (20130101) G06K 9/4604 (20130101) G06K 9/4642 (20130101) G06K 9/6212 (20130101) Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 3/0068 (20130101) G06T 3/0093 (20130101) G06T 5/008 (20130101) G06T 5/20 (20130101) G06T 7/0012 (20130101) G06T 7/0014 (20130101) G06T 7/0016 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210350538 | TAUBE et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Janis Marie TAUBE (Baltimore, Maryland); Sandor SZALAY (Baltimore, Maryland) |
| ABSTRACT | A device may obtain field images of a tissue sample, apply, to the field images, spatial distortion and illumination-based corrections (including corrections for photobleaching of reagents) to derive processed field images, identify, in each processed field image, a primary area including data useful for cell or subcellular component characterization, identify, in the processed field images, areas that overlap with one another, and derive information regarding a spatial mapping of cell(s) and/or sub-cellular components of the tissue sample. Deriving the information may include performing segmentation based on the data included in the primary area of each processed field image, and obtaining flux measurements based on other data included in the overlapping areas. The device may cause the information to be loaded in a data structure to enable statistical analysis of the spatial mapping for identifying factors defining normal tissue structure, associated inflammatory or neoplastic diseases and prognoses thereof, and associated therapeutics. |
| FILED | Thursday, September 19, 2019 |
| APPL NO | 17/278112 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/367 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/46 (20130101) G06K 9/6267 (20130101) G06K 2209/05 (20130101) Image Data Processing or Generation, in General G06T 3/4038 (20130101) G06T 5/006 (20130101) G06T 5/009 (20130101) G06T 7/11 (20170101) G06T 7/0014 (20130101) Original (OR) Class G06T 2200/24 (20130101) G06T 2207/10056 (20130101) G06T 2207/20076 (20130101) G06T 2207/20092 (20130101) G06T 2207/30024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210350725 | Park et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clara Park (Cambridge, Massachusetts); Xuanhe Zhao (Cambridge, Massachusetts); Hyunwoo Yuk (Cambridge, Massachusetts); Christopher Tam Nguyen (Cambridge, Massachusetts); Ellen T. Roche (Cambridge, Massachusetts) |
| ABSTRACT | A biorobotic hybrid heart that preserves organic intracardiac structures and mimics cardiac motion by image-guided replication of the cardiac myofiber architecture of the left ventricle with an active synthetic myocardium that drives the motion of the heart. The active soft tissue mimic is adhered to the organic endocardial tissue in a helical fashion using a custom-designed adhesive to form a flexible, conformable, and watertight organosynthetic interface. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193910 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/08 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/32 (20130101) Original (OR) Class G09B 23/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210351544 | Judy et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Judy (Gainesville, Florida); Paritosh Rustogi (Gainesville, Florida) |
| ABSTRACT | Embodiments are provided that enable an implantable connector, along with related apparatuses, devices, systems, methods, computing devices, computing entities, and/or the like to serve patients with neural interfaces requiring connectors with higher channel densities (>0.05 ch/mm3) or higher channel counts (>32) than is practical with conventional implant-connector technology. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282894 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3754 (20130101) Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/621 (20130101) H01R 13/2407 (20130101) H01R 13/5219 (20130101) Original (OR) Class H01R 43/205 (20130101) H01R 2201/12 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 5/04 (20130101) H05K 5/0008 (20130101) H05K 5/0095 (20130101) H05K 5/0247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210345720 | Snow et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jacob Snow (Bremerton, Washington); Jacob Yates (Poulsbo, Washington); Nathan Schuyler (Silverdale, Washington) |
| ABSTRACT | A face shield for use with protective headgear can be shipped flat and easily assembled from a kit of parts without the use of tools or adhesives. The face shield protects against disease, aerosols and splatter that may contain pathogens; may include a curved lower perimeter to facilitate head movements, and can be taken on and off easily. |
| FILED | Friday, September 25, 2020 |
| APPL NO | 16/974092 |
| CURRENT CPC | Hats; Head Coverings A42B 3/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346419 | Venn-Watson |
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| FUNDED BY |
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| APPLICANT(S) | EPITRACKER, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephanie Venn-Watson (San Diego, California) |
| ABSTRACT | Compositions including metabolites that are small molecules, and salts and derivatives thereof, and methods for treatment or prophylaxis of conditions related to the quality of aging are provided, including compositions and methods for treating conditions that negatively impact longevity and the quality of aging, including asthma, autoimmune disease, cancer, cardiovascular disease, inflammation, anemia, hyperglycemia, dyslipidemia, hyperinsulinemia, liver disease, iron overload, impaired skin integrity, wound healing, scarring, pain, allergies, respiratory diseases, sleep disorders, sleep problems, gastrointestinal disorders, and gastrointestinal problems. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380622 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/40 (20160801) A23L 33/175 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/192 (20130101) A61K 31/708 (20130101) A61K 31/7028 (20130101) A61K 31/7076 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/00 (20180101) A61P 3/06 (20180101) A61P 3/10 (20180101) A61P 7/06 (20180101) A61P 11/06 (20180101) A61P 17/02 (20180101) A61P 29/00 (20180101) A61P 37/02 (20180101) A61P 37/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346480 | DISIS et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (SEATTLE, Washington) |
| INVENTOR(S) | Mary L. DISIS (RENTON, Washington); Denise CECIL (SHORELINE, Washington); Meredith SLOTA (SEATTLE, Washington) |
| ABSTRACT | The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/304823 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) Original (OR) Class A61K 39/00115 (20180801) A61K 39/001103 (20180801) A61K 39/001106 (20180801) A61K 39/001129 (20180801) A61K 39/001152 (20180801) A61K 48/00 (20130101) A61K 2039/53 (20130101) A61K 2039/572 (20130101) Peptides C07K 14/71 (20130101) C07K 14/705 (20130101) C07K 14/4702 (20130101) C07K 14/70567 (20130101) C07K 14/70596 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/104 (20130101) Enzymes C12Y 203/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346700 | Wilder et al. |
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| FUNDED BY |
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| APPLICANT(S) | VERITAS IP, LLC (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Miller Wilder (Salt Lake City, Utah); Scott Darold Hiatt (South Jordan, Utah); Steven John Barrus (North Salt Lake, Utah); Cliff C. Nixon (Phoenix, Arizona) |
| ABSTRACT | Disclosed herein are various embodiments of an interface control subsystem that may be used between an electrode terminal and a recording terminal of a neurostimulation and neurorecording system. The interface control subsystem may operate in three modes. In a disable mode, a first transistor and a second transistor disposed between the electrode terminal and the recording terminal may operate in a cutoff region and generate a high impedance. In an active mode, the first transistor and the second transistor may operate in a saturation region and generate a low impedance. In a stimulation mode, the first transistor and the second transistor operate in a triode region and generate an impedance between the high impedance of the disable mode and the low impedance of the active mode. The interface control subsystem may further limit voltage at the recording terminal in response to a detected overvoltage condition. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/315160 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/301 (20210101) A61B 5/7217 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/025 (20130101) A61N 1/36128 (20130101) Original (OR) Class A61N 2001/083 (20130101) Electric Digital Data Processing G06F 3/015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346738 | Howland |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| INVENTOR(S) | Glenn E. Howland (Acton, Maine) |
| ABSTRACT | An electrical safety system and method is provided which includes a flexible electrical safety vest, a lifeline coupled with the vest in various configurations, and leg straps. The electrical safety vest includes a number of loops which are used to couple the lifeline in a variety of relationships that enable different types of maneuvering of a worker with relation to a hazard. Various embodiments of the invention can be used to rapidly and safety remove a worker from proximity to an immediate threat to their life, health, or safety. Direct and indirect extraction from a danger are enabled. A variety of methods are also provided for operating various embodiments of the invention. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381567 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 1/04 (20130101) A41D 13/0007 (20130101) A41D 13/008 (20130101) A41D 2600/20 (20130101) Devices, Apparatus or Methods for Life-saving A62B 35/0018 (20130101) Original (OR) Class A62B 35/0037 (20130101) A62B 35/0043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347046 | WANDZEL et al. |
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| FUNDED BY |
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| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arthur Richard WANDZEL (Orchard Lake, Michigan); Stefanie TELLEX (Providence, Rhode Island) |
| ABSTRACT | A system and method of operating a mobile robot to perform tasks includes representing a task in an Object-Oriented Partially Observable Markov Decision Process model having at least one belief pertaining to a state and at least one observation space within an environment, wherein the state is represented in terms of classes and objects and each object has at least one attribute and a semantic label. The method further includes receiving a language command identifying a target object and a location corresponding to the target object, updating the belief associated with the target object based on the language command, driving the mobile robot to the observation space identified in the updated belief, searching the updated observation space for each instance of the target object, and providing notification upon completing the task. In an embodiment, the task is a multi-object search task. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 17/280365 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1661 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347266 | Bernhardt et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger D. Bernhardt (St. Charles, Missouri); Daniel J. Clingman (Milton, Washington) |
| ABSTRACT | Structural members containing energy storage are disclosed. An example apparatus includes a first spring unit having a first plate spaced from a second plate and a first biasing element positioned between the first plate and the second plate. The first biasing element enables the first plate to move relative to the second plate in a direction along a longitudinal axis of the apparatus. A second spring unit has a third plate spaced from a fourth plate and a second biasing element positioned between the third plate and the fourth plate. The second biasing element enables the third plate to move relative to the fourth plate along the longitudinal axis of the apparatus. A battery is positioned between the first spring unit and the second spring unit. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 16/869191 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/66 (20190201) Original (OR) Class Aeroplanes; Helicopters B64C 3/187 (20130101) B64C 39/024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347463 | Walter |
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| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew W. Walter (Troy, Missouri) |
| ABSTRACT | Aircraft canopy jettison systems, apparatus, and methods are described herein. An example aircraft includes a forward fuselage defining a cockpit, a seat in the cockpit, a pivot pin coupled to the forward fuselage, and a canopy removably coupled to the forward fuselage over the cockpit. The canopy includes a frame having a hinge portion. The hinge portion includes a cam. The cam is dimensioned such that when the canopy is jettisoned while the aircraft is at zero altitude and zero airspeed, a travel path of the hinge portion does not intersect a travel path of the seat when the seat is ejected while the aircraft is at zero altitude and zero airspeed. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 16/869035 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 1/32 (20130101) B64C 1/1476 (20130101) Original (OR) Class Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 25/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347466 | Sumerel |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Sumerel (Chicago, Illinois) |
| ABSTRACT | An example method includes receiving pitch angle sensor information indicative of a pitch angle of a vehicle, wherein the vehicle comprises a main landing gear having a strut and a pitch control surface configured to control the pitch angle of the vehicle; determining a trailing-edge-up limit for upward movement of the pitch control surface to control a de-rotation rate of the vehicle as the vehicle lands; receiving load sensor information indicative of a load on the strut of the main landing gear of the vehicle; based on the pitch angle of the vehicle being below a pitch angle threshold, determining an updated trailing-edge-up limit based on the load on the strut; and controlling the pitch control surface based on the updated trailing-edge-up limit. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 16/868274 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 9/00 (20130101) B64C 13/16 (20130101) Original (OR) Class B64C 25/58 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 5/16 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0808 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347493 | Reller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan L. Reller (Vail, Arizona); Nicholas F. Collison (Tucson, Arizona); Paul T. Hudak (Vail, Arizona) |
| ABSTRACT | A highly adaptive seal for use in advanced aircraft propulsion and missile systems is provided. The seal is capable of effectively limiting invasive thermal energy and corrosive airflow from entering the internal systems and hardware of the aircraft by managing and controlling the incoming air flow. The seal is configured to be disposed between component parts of the aircraft and create a tortuous path for air flow. The seal maintains contact with the component parts between which it seals by allowing for significant radial and axial displacement freedom of the component parts. Accordingly, hot gas intrusion may be limited in a wide variety of dynamic environments and component displacement conditions. Limiting such hot gas intrusion has a substantial impact on component survivability over the course of free flight of an aircraft. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 16/869028 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 29/04 (20130101) Original (OR) Class Pistons; Cylinders; Sealings F16J 15/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347646 | Rey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Gabrielle Sabrina Rey (Maple Heights, Ohio); Saranshu Singla (Akron, Ohio); Ali Dhinojwala (Akron, Ohio); Stephanie Vivod (Euclid, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabrielle Sabrina Rey (Maple Heights, Ohio); Saranshu Singla (Akron, Ohio); Ali Dhinojwala (Akron, Ohio); Stephanie Vivod (Euclid, Ohio) |
| ABSTRACT | A process of preparing a polydopamine aerogel comprising first mixing together a silica precursor and an amine-functionalized silica precursor in a solvent to form a first solution. Then, adding an acid catalyst to the first solution to form a silica gel. Then, equilibrating the silica gel in a 50/50 solvent/water mixture. Wherein the final step in the process is to add about 1 mg/ml solution of a dopamine monomer to the silica gel to form a polydopamine aerogel. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/025153 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 33/155 (20130101) C01B 33/159 (20130101) Original (OR) Class C01B 33/1585 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347654 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aegis Technology Inc. (Santa Ana, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qi Chen (Santa Ana, California); Zhigang Lin (Santa Ana, California) |
| ABSTRACT | Producing CoxFe100-x, where x is an integer from 20 to 95, nanoparticles by: (a) providing a first aqueous hydroxide solution; (b) preparing a second aqueous solution containing iron ions and cobalt ions; and (c) depositing measured volumes of the second aqueous solution into the first aqueous solution whereby coprecipitation yields CoFe alloy nanoparticles, wherein step (c) occurs in an essentially oxygen-free environment. The nanoparticles are annealed at ambient temperatures to yield soft nanoparticles with targeted particle size, saturation magnetization and coercivity. The chemical composition, crystal structure and homogeneity are controlled at the atomic level. The CoFe magnetic nanoparticles have Ms of 200-235 emu/g, (Hc) coercivity of 18 to 36 Oe and size range of 5-40 nm. The high magnetic moment CoFe nanoparticles can be employed in drug delivery, superior contrast agents for highly sensitive magnetic resonance imaging, magnetic immunoassay, magnetic labeling, waste water treatment, and magnetic separation. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336310 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 49/0009 (20130101) C01G 51/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347823 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Fundação Universidade Federal do ABC - UFABC (Federal University of ABC Foundation) (Santo André, Brazil) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Fundação Universidade Federal do ABC - UFABC (Federal University of ABC Foundation) (Santo André, Brazil) |
| INVENTOR(S) | Timothy Kuan-Ta Lu (Cambridge, Massachusetts); Cesar de la Fuente Nunez (Philadelphia, Pennsylvania); Vani Xavier de Oliveira Junior (Rodovia Regis Bittencourt, Brazil); Marcelo Der Torossian Torres (Philadelphia, Pennsylvania) |
| ABSTRACT | Described herein are methods of physicochemical-guided peptide design that utilize specific functional determinants to a protein's property of interest. Also described herein are novel synthetic peptide antibiotics that have increased potency and/or decreased toxicity relative to the template peptide from which they were derived, and methods of use thereof in treating microbial infections. |
| FILED | Thursday, September 19, 2019 |
| APPL NO | 17/277783 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) A61P 31/10 (20180101) Peptides C07K 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347863 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinny Lin Liu (Ellicott City, Maryland); George P. Anderson (Bowie, Maryland); Ellen R. Goldman (Germantown, Maryland) |
| ABSTRACT | Described herein are nucleic acids encoding single-domain antibodies that might serve as alternatives to conventional monoclonal antibodies for either the detection or treatment of Chikungunya Virus (CHIKV). |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/245180 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/1081 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/569 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/36111 (20130101) C12N 2770/36123 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/181 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348006 | Beatty |
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| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Michael C. Beatty (Long Beach, California) |
| ABSTRACT | The present disclosure is directed to a method of chemically stripping a surface. The method comprises applying a sealant to at least a portion of a surface of an object, the surface comprising a coating and one or more ingression points, the sealant filling the one or more ingression points to form a sealed surface. The method further comprises applying a stripping agent to the sealed surface to remove at least a portion of the coating to form a stripped surface. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 16/870698 |
| CURRENT CPC | Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/40 (20170101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/34 (20130101) C09D 9/005 (20130101) Original (OR) Class C09D 181/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348021 | WEBSTER et al. |
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| FUNDED BY |
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| APPLICANT(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| ASSIGNEE(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| INVENTOR(S) | Dean C. WEBSTER (Fargo, North Dakota); Alireza RAHIMI (N. Royalton, Ohio) |
| ABSTRACT | The invention is directed to curable polyurethane coating compositions which may be used to form fouling release coatings, e.g., for use in protecting boat hulls. A curable coating composition of the invention comprises a) at least one amphiphilic additive; b) at least one polyisocyanate; c) at least one polyol; and d) optionally, at least one amphiphilic PEG-PDMS isocyanate prepolymer. Another curable coating composition of the invention comprises the at least one polyisocyanate, b), the at least one polyol, c), and the at least one amphiphilic PEG-PDMS isocyanate prepolymer, d). The invention further relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the steps of coating the surface with the curable coating compositions of the invention to form a coated surface, and curing the coating composition on the coated surface. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/191035 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/283 (20130101) C08G 18/289 (20130101) C08G 18/725 (20130101) C08G 18/755 (20130101) C08G 18/792 (20130101) C08G 18/6229 (20130101) C08G 18/8064 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1637 (20130101) C09D 175/04 (20130101) C09D 175/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348133 | Lock et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Lock (Southampton, Pennsylvania); Mauricio Alvira (Philadelphia, Pennsylvania) |
| ABSTRACT | A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 17/379359 |
| CURRENT CPC | Separation B01D 15/3804 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/281 (20130101) B01J 41/05 (20170101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/02 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/8645 (20130101) C12N 2750/14151 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348217 | RODRIQUES et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); BROAD INSTITUTE, INC (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Gordon RODRIQUES (Cambridge, Massachusetts); Edward BOYDEN (Chestnut Hill, Massachusetts); Fei CHEN (Cambridge, Massachusetts); Linlin CHEN (Cambridge, Massachusetts); Sophia LIU (Roxbury, Massachusetts); Ellen ZHONG (Cambridge, Massachusetts); Joseph SCHERRER (Boston, Massachusetts) |
| ABSTRACT | The invention, in some aspects, includes systems, methods and components of molecular recorders that encode the timing of transcriptional activity into the sequence of RNA, which can then enable a sequencing-based readout of the internal dynamics of cells. |
| FILED | Tuesday, July 16, 2019 |
| APPL NO | 17/150620 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/78 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6811 (20130101) Original (OR) Class Enzymes C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348230 | Walter et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nils Walter (Ann Arbor, Michigan); Muneesh Tewari (Ann Arbor, Michigan); Alexander Johnson-Buck (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein is technology relating to detecting and identifying nucleic acids and particularly, but not exclusively, to compositions, methods, kits, and systems for detecting, identifying, and quantifying target nucleic acids with high confidence at single-molecule resolution. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319289 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6832 (20130101) C12Q 1/6834 (20130101) C12Q 1/6876 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348619 | DeFelice et al. |
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| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| INVENTOR(S) | Robert DeFelice (South Windsor, Connecticut); Scott W. Simpson (Easthampton, Massachusetts); Josh Kamp (Glastonbury, Connecticut) |
| ABSTRACT | A bleed valve includes a housing with an inlet coupled to an outlet by a duct, a guide tube with an orifice fixed in the housing between the inlet and the outlet, a piston, and baffle. The piston is slideably supported on the guide tube and is movable between an open and a closed position, the duct fluidly coupling the inlet and outlet in the open position, the duct fluidly separating the inlet and outlet in the closed position. The orifice fluidly couples the inlet and outlet in the open and closed positions to move piston between the open and closed positions according to differential pressure between the bleed valve inlet and outlet. The baffle is slideably supported by the guide tube to set the differential pressure at which the piston moves between the open and closed positions. Gas turbines and differential pressure adjustment methods are also described. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193235 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 17/105 (20130101) F01D 17/145 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 6/08 (20130101) F02C 9/18 (20130101) Non-positive-displacement Pumps F04D 27/023 (20130101) F04D 27/0215 (20130101) Original (OR) Class Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 1/126 (20130101) F16K 15/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348969 | Yao et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Yu Yao (Chandler, Arizona); Jing Bai (Tempe, Arizona) |
| ABSTRACT | A circular polarization filter of a chiral metasurface structure is disclosed including a substrate having a nanograting pattern extending from the substrate, a dielectric layer formed directly on the nanograting pattern, and a plasmonic structure in direct contact with the dielectric layer, where the plasmonic structure may be oriented at a nonzero angle with respect to the nanograting pattern. An integrated polarization filter array is also disclosed including include a linear polarization filter, and a circular polarization filter. Methods of detecting full-stokes polarization using an integrated polarization filter array having both linear and circular polarization filters made from chiral metasurface structures is disclosed. Methods of using a Mueller matrix to evaluate polarization response of any optical device or system is also disclosed. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157438 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/447 (20130101) G01J 4/04 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/21 (20130101) Optical Elements, Systems, or Apparatus G02B 5/008 (20130101) G02B 5/3041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349055 | Cooks et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Nicolás M. Morato (West Lafayette, Indiana); Dylan T. Holden (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to high-throughput label-free enzymatic bioassays using desorption electrospray ionization-mass spectrometry (DESI-MS). |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193120 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/64 (20130101) G01N 27/622 (20130101) Original (OR) Class G01N 27/626 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0409 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349087 | BUSER et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Joshua BUSER (Seattle, Washington); Joshua BISHOP (Seattle, Washington); Dylan GUELIG (Seattle, Washington); Arielle HOWELL (Seattle, Washington); Sujatha KUMAR (Seattle, Washington); Paul YAGER (Seattle, Washington); Koji ABE (Seattle, Washington); Erin HEINIGER (Seattle, Washington); Samantha BYRNES (Seattle, Washington); Caitlin ANDERSON (Seattle, Washington); Peter C. KAUFFMAN (Seattle, Washington); Maxwell WHEELER (Seattle, Washington) |
| ABSTRACT | The present technology generally relates to stopped-flow microfluidic devices. Select embodiments of the present technology include microfluidic devices having a first porous element configured to receive a first fluid and a second porous element configured to receive a second fluid. The second porous element can have one or more legs overlapping with the first porous element. The device can be configured such that (a) delivery of the first fluid to the first porous element causes the first fluid to flow along the length of the first porous element without substantially wetting the one or more legs, and (b) delivery of the second fluid to the second porous element causes the second fluid to flow into the overlapping regions of the first porous element, thereby substantially stopping flow of the first fluid along at least a portion of the first porous element. |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 17/278166 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 3/502738 (20130101) B01L 2300/069 (20130101) B01L 2300/126 (20130101) B01L 2300/0636 (20130101) B01L 2300/0825 (20130101) B01L 2400/0406 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/558 (20130101) Original (OR) Class G01N 33/54306 (20130101) G01N 33/54313 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349167 | WU et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); CEDARS-SINAI MEDICAL CENTER (LOS ANGELES, California) |
| INVENTOR(S) | YIJEN LIN WU (WEXFORD, Pennsylvania); ANTHONY CHRISTODOULOU (LOS ANGELES, California) |
| ABSTRACT | A magnetic resonance imaging method is includes collecting spatially encoded data from a subject using an MRI system, and directly extracting a number of temporal basis functions using at least a first portion of the spatially encoded data. The method further includes, after directly extracting the number of temporal basis functions, iteratively calculating a number of coefficient images using the number of temporal basis functions and at least a second portion of the spatially encoded data. Finally, the method includes generating a 4D image based on the number of temporal basis functions and the number of coefficient images. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245342 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4818 (20130101) G01R 33/5611 (20130101) G01R 33/56308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349281 | AUGST et al. |
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| FUNDED BY |
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| APPLICANT(S) | Steven J. AUGST (Acton, Massachusetts); Peter O'Brien (Derry, New Hampshire); Jonathan Wilson (Hampstead, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven J. AUGST (Acton, Massachusetts); Peter O'Brien (Derry, New Hampshire); Jonathan Wilson (Hampstead, New Hampshire) |
| ABSTRACT | High-power light absorbers (HPLAs) can exhibit low back-scattered light, mitigate stray light, and withstand high optical power. The absorbers can be used with or without baffling as beam dumps for high-power lasers. An HPLA may include a substrate made of high thermally conductive material with an anti-reflection (AR) coating formed on the substrate. A thin layer of highly absorbing material may be located between the AR coating and substrate. The substrate can be cooled with a fluid, such as water or air. |
| FILED | Tuesday, December 22, 2020 |
| APPL NO | 17/130598 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/11 (20130101) G02B 5/003 (20130101) G02B 5/284 (20130101) G02B 7/008 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349324 | Vuong et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luat Vuong (Riverside, California); Baurzhan Muminov (Riverside, California); Ji Feng (Riverside, California) |
| ABSTRACT | Described herein are imaging devices and associated methods. Devices and methods are described that include a plurality of topological phase modulators. In one example, the plurality of topological phase modulators includes an array of spiral vortices. Devices and methods are described that include a neural network to reconstruct images using data from the plurality of topological phase modulators. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314895 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Optical Elements, Systems, or Apparatus G02B 3/0006 (20130101) G02B 27/0905 (20130101) Original (OR) Class G02B 27/4205 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349723 | HU et al. |
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| FUNDED BY |
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| APPLICANT(S) | DEEPBITS TECHNOLOGY INC. (Riverside, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | DEEPBITS TECHNOLOGY INC. (Riverside, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Xunchao HU (Riverside, California); Sheng YU (Riverside, California); Heng YIN (Riverside, California) |
| ABSTRACT | The present invention performs high-throughput disassembly for executable code comprising a plurality of instructions. An input of the executable code is received. Exhaustive disassembly is performed on the executable code to produce a set of exhaustively disassembled instructions. An instruction flow graph is constructed from the exhaustively disassembled instructions. Instruction embedding is performed on the exhaustively disassembled instructions to construct embeddings. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/243570 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/53 (20130101) G06F 9/3838 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210350947 | Houten et al. |
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| FUNDED BY |
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| APPLICANT(S) | Spark Thermionics, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyana Van Houten (Berkeley, California); Lucas Heinrich Hess (Berkeley, California); Jared William Schwede (Berkeley, California); Felix Schmitt (Berkeley, California) |
| ABSTRACT | A thermionic energy conversion system, preferably including one or more electron collectors, interfacial layers, encapsulation, and/or electron emitters. A method for manufacturing the thermionic energy conversion system. A method of operation for a thermionic energy conversion system, preferably including receiving power, emitting electrons, and receiving the emitted electrons, and optionally including convectively transferring heat. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313945 |
| CURRENT CPC | Obtaining Energy From Radioactive Sources; Applications of Radiation From Radioactive Sources, Not Otherwise Provided For; Utilising Cosmic Radiation G21H 1/106 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210351401 | LIU et al. |
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| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guoliang LIU (Blacksburg, Virginia); Tianyu LIU (Blacksburg, Virginia) |
| ABSTRACT | Porous carbon fiber electrode materials are provided having fast electron and ion transport. The porous carbon fiber electrodes include uniform mesoscale pores that are partially filled with a metal oxide layer. With large mass loadings of metal oxide, porous carbon fiber electrodes described herein can outperform conventional metal oxide electrodes at similar loadings. In various aspects, electrode materials are provided having (i) a porous carbon fiber support with a plurality of mesoscale pores having an internal surface and an average pore width of about 2 mm to about 200 mm; and (ii) a metal oxide layer on at least the internal surface of the mesoscale pores. Methods of making the porous carbon fiber electrode materials are also provided. Using a microphase-separation of block copolymers, the methods can provide porous carbon fiber supports with interconnected and uniform mesoscale pores that can be deposited with a metal oxide layer. |
| FILED | Friday, September 06, 2019 |
| APPL NO | 17/273718 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/24 (20130101) H01G 11/26 (20130101) H01G 11/40 (20130101) H01G 11/86 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/88 (20130101) H01M 4/96 (20130101) H01M 4/133 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/0471 (20130101) H01M 4/583 (20130101) H01M 4/1393 (20130101) H01M 4/8605 (20130101) H01M 4/8657 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210351443 | Treger et al. |
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| FUNDED BY |
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| APPLICANT(S) | CAMX Power LLC (Lexington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack Treger (Quincy, Massachusetts); Kacy Tully (Lexington, None) |
| ABSTRACT | A low voltage electrochemical cell is provided that includes a metallic anode including an anode metal, a metallic cathode including a cathode metal, the metallic cathode further including a surface layer including an alloy of the anode metal and the cathode metal, an electrolyte disposed between the metallic anode and the metallic cathode, and a separator within the electrolyte or embedded with electrolyte. The electrochemical cell further includes a voltage stabilization electron current between said anode and said cathode, where the voltage stabilization electron current has an amperage capable of maintaining an open load circuit voltage of the electrochemical cell that varies by less than 10 percent over 10 hours or greater, optionally a month or greater, optionally over the cell lifetime, or a non-equilibrium anode metal/cathode metal ratio in the surface layer for 10 hours or greater, optionally a month or greater, optionally over the cell lifetime. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314375 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 10/4257 (20130101) Original (OR) Class H01M 2004/027 (20130101) H01M 2010/4271 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210351559 | Langseth et al. |
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| FUNDED BY |
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| APPLICANT(S) | Jason E. Langseth (Malden, Massachusetts); Andrew Benedick (Stow, Massachusetts); Seth TROTZ (Acton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason E. Langseth (Malden, Massachusetts); Andrew Benedick (Stow, Massachusetts); Seth TROTZ (Acton, Massachusetts) |
| ABSTRACT | In coherent beam combining, the beams can be phase-modulated with a pseudo-random bit sequence (PRBS) to prevent stimulated Brillouin scattering (SBS) downstream. To coherently combine the phase-modulated beams, however, the PRBS waveforms should be true-time-delayed to within a small fraction of the bit duration. Traditionally, this true time delay is achieved by cutting optical fibers to length or with optical trombones. But trimming fibers is hard to do precisely, and optical trombones have large insertion loss. In addition, the path length mismatch varies as the fibers heat up and/or vibrate. Here, the beams are generated from a kilohertz linewidth seed split among N>1 (e.g., N=100) arms. Each arm is phase-modulated with a separate copy of the unique PRBS pattern. The relative phase of the PRBS patterns is stabilized by phase-locking the master oscillators used to read out the PRBS patterns. The PRBS patterns can be phase shifted with respect to one another to compensate for physical path length mismatches of the optical fibers. Scanning the relative phase of the PRBS pattern used to modulate different arms yields a cross-correlation peak in combined power when the phases are matched at the combination plane. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/195115 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/1305 (20130101) H01S 3/1307 (20130101) H01S 3/2308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210351564 | SHEIK-BAHAE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mansoor SHEIK-BAHAE (Albuquerque, New Mexico); Alexander Robert ALBRECHT (Albuquerque, New Mexico); Zhou YANG (Albuquerque, New Mexico) |
| ABSTRACT | A vertical-external-cavity surface-emitting laser (VECSEL) and a method of forming the VECSEL is disclosed. The VECSEL includes a heat sink; a heat spreader or heat spreader formed on a top surface of the heat sink, where the heat spreader comprises a first material having a first refractive index; and a high contrast grating formed on a top surface of the heat spreader or active region, wherein the high contrast grating comprises an active region and the high contrast grating comprising a second material having a second refractive index, the second refractive index is greater than the first refractive index. |
| FILED | Thursday, September 19, 2019 |
| APPL NO | 17/277669 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/041 (20130101) H01S 5/02469 (20130101) Original (OR) Class H01S 5/02484 (20130101) H01S 5/3013 (20130101) H01S 5/18361 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210352060 | Roy |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radhika Roy (Howell, New Jersey) |
| ABSTRACT | Various embodiments that pertain to network functions are described. A network can be an ad hoc network that function with peer-to-peer communications. The network can be physically decentralized, yet logically centralized. Various functions can be practiced within this network environment. In one example, a provider can provide an authorization to a robot by way of a peer-to-peer communication. The robot can validate the authorization and practice what is authorized in response to the authorization being validated. This authorization can be to perform a function autonomously for a defined length of time. |
| FILED | Tuesday, May 05, 2020 |
| APPL NO | 16/866585 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4155 (20130101) G05B 2219/34456 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/08 (20130101) Original (OR) Class H04L 67/104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210352095 | Cam |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Labortary (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hasan Cam (Columbia, Maryland) |
| ABSTRACT | A technique for providing cyber resilience by integrating autonomous adversary and defender agents, deep learning, and graph thinking. An automated competitive environment of autonomous adversary and defender agents is provided such that the adversary agent can emulate the adversary activities, patterns, and intentions using all available cybersecurity measurements and observations, and, the defender agent can generate and suggest the best possible appropriate actions to mitigate or prevent adversary activities while recovering or protecting assets. An automated cyber resilience system with autonomous agents is provided using machine learning and security analytics to first predict the current and future adversary activities and then provide an automated critical asset protection and recovery by enabling agents to take appropriate reactive and pro-active actions at each time step to prevent, recover, or mitigate adversary activities over enterprise and tactical networks. |
| FILED | Tuesday, May 05, 2020 |
| APPL NO | 16/866583 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/145 (20130101) H04L 63/1433 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210352519 | Greel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Greel (Bel Air, Maryland); Radhika Roy (Howell, New Jersey); Rocio Bauer (Peach Bottom, Pennsylvania) |
| ABSTRACT | A cross-layer security scheme can be used for a Multi-Input Multi-Output (MIMO) antenna-based large-scale multihop mobile ad hoc network (MANET) with a set of frequency-nonselective, slow/Rayleigh fading, and uncoded channels along with interference combining both physical, link, and higher layer encryption techniques for the payload in addition to signaling. Furthermore, MIMO-aware cross-layer secure MANET physical and key-based logical hierarchical routing proving scalability can be used. Security can be provided in Multi-Hop MIMO MANETs in Physical, medium access control (MAC), and internet protocol (IP) Routing layer. The MIMO-aware MANET IP Routing can include two kinds of routing: Physical Routing such as secure ad-hoc on-demand distance vector (SAODV) in the access MANET and Secure Key-based distributed hash table (DHT) “logical” routing in the backbone MANET. Both security and performance metrics can be employed to improve (e.g., optimize) both network secrecy and throughput/bandwidth capacity. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/327814 |
| CURRENT CPC | Transmission H04B 7/024 (20130101) H04B 17/336 (20150115) Wireless Communication Networks H04W 12/04 (20130101) H04W 28/085 (20130101) H04W 28/0236 (20130101) H04W 28/0263 (20130101) Original (OR) Class H04W 40/28 (20130101) H04W 84/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210346837 | Ritter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | James A. Ritter (Gilbert, South Carolina); Armin D. Ebner (Lexington, South Carolina); Charles E. Holland (Cayce, South Carolina) |
| ABSTRACT | The current disclosure provides systems and methods for multiple beds undergoing a feed step at the same time with the same feed flow rate and multiple beds undergoing a light reflux step at the same time with the same light reflux flow rate to process a gas stream in a multi-bed, multi-unit vacuum swing adsorption (VSA) process using reasonably sized beds. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/194759 |
| CURRENT CPC | Separation B01D 53/0407 (20130101) B01D 53/0476 (20130101) Original (OR) Class B01D 2253/108 (20130101) B01D 2253/304 (20130101) B01D 2257/504 (20130101) B01D 2259/402 (20130101) B01D 2259/40013 (20130101) B01D 2259/40028 (20130101) B01D 2259/40041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346838 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bu Wang (Madison, Wisconsin); Raghavendra Ragipani (Madison, Wisconsin) |
| ABSTRACT | A method of reducing sulfur concentration in fly ash, flue gas desulfurization (FGD) ash, and mixtures thereof by contacting the fly ash, FGD ash, or mixtures thereof with an aqueous acidic solution, for a time, at a temperature, and at a liquid-to-solid ratio wherein the sulfur concentration within the fly ash, FGD ash, or mixture thereof is reduced to no more than 5 wt % SO3 based on the total weight of dry fly ash, FGD ash, or mixture thereof so treated. |
| FILED | Monday, May 11, 2020 |
| APPL NO | 16/871508 |
| CURRENT CPC | Separation B01D 53/1475 (20130101) Original (OR) Class B01D 2258/0283 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 18/08 (20130101) C04B 20/023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346863 | PARANTHAMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MARIAPPAN PARANS PARANTHAMAN (Knoxville, Tennessee); CONSTANTINOS TSOURIS (Oak Ridge, Tennessee); SAMUEL F. EVANS (Knoxville, Tennessee); MARKO R. IVANCEVIC (Lombard, Illinois) |
| ABSTRACT | An adsorbent for a target compound can include porous carbon particles having pores with a predominant pore size less than 10 nm, and magnetic nanoparticles (MNP) nucleated on the carbon surface and within the pores of carbon particles to provide a carbon magnetic nanoparticle adsorbent (C-MNA). A method for removing target compounds with an adsorbent, a system for removing contaminants from a liquid, and a method for adsorbing target compounds from a fluid are also disclosed. |
| FILED | Tuesday, May 05, 2020 |
| APPL NO | 16/867022 |
| CURRENT CPC | Separation B01D 15/10 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/20 (20130101) Original (OR) Class B01J 20/2805 (20130101) B01J 20/2808 (20130101) B01J 20/3231 (20130101) B01J 20/3416 (20130101) B01J 20/3475 (20130101) B01J 20/28004 (20130101) B01J 20/28009 (20130101) B01J 20/28016 (20130101) B01J 20/28059 (20130101) B01J 20/28061 (20130101) B01J 20/28064 (20130101) B01J 20/28066 (20130101) B01J 20/28083 (20130101) B01J 20/28085 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/01 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/66 (20130101) C02F 1/283 (20130101) C02F 2101/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346864 | Baumann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (, None) |
| INVENTOR(S) | Theodore F. Baumann (Discovery Bay, California); Joe H. Satcher, JR. (Patterson, California); Joseph C. Farmer (Tracy, California) |
| ABSTRACT | A method includes forming a carbon aerogel on a substrate to produce a highly adsorptive structure. The carbon aerogel is characterized by having physical characteristics of in-situ formation on the substrate. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/351034 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/06 (20130101) B01J 20/20 (20130101) Original (OR) Class B01J 20/103 (20130101) B01J 20/2804 (20130101) B01J 20/3085 (20130101) B01J 20/28042 (20130101) B01J 20/28047 (20130101) B01J 20/28052 (20130101) B01J 20/28066 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/047 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 17/083 (20130101) F25B 27/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346916 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sortera Alloys, Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | Sortera Alloys, Inc. (Fort Worth, Texas) |
| INVENTOR(S) | Nalin Kumar (Fort Worth, Texas); Manuel Gerardo Garcia, JR. (Lexington, Kentucky); Kanishka Tyagi (Meerut, India) |
| ABSTRACT | Systems and methods for classifying materials utilizing one or more sensor systems, which may implement a machine learning system in order to identify or classify each of the materials, which may then be sorted into separate groups based on such an identification or classification. The machine learning system may utilize a neural network, and be previously trained to recognize and classify certain types of materials. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380928 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346951 | SAKAMOTO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JEFFREY SAKAMOTO (Ann Arbor, Michigan); MICHAEL WANG (Ann Arbor, Michigan); NATHAN TAYLOR (Ann Arbor, Michigan) |
| ABSTRACT | A method of and apparatus for sinter forging a precursor powder to form a film may reduce or eliminate the stress in the film and may facilitate processing of continuous length of films such as ceramic films for use in batteries. The precursor powder can be provided on a substrate and is simultaneously heated and pressed in a pressing direction parallel to a thickness of the film so as to sinter and densify the precursor powder to form the film in a sinter forging area. Notably, in a plane perpendicular to the pressing direction, there are no lateral constraints on the sinter forging area or the material received therein. |
| FILED | Monday, February 01, 2021 |
| APPL NO | 17/163726 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0059 (20130101) B22F 3/03 (20130101) B22F 3/14 (20130101) Original (OR) Class B22F 3/105 (20130101) B22F 5/006 (20130101) B22F 2003/1053 (20130101) B22F 2203/11 (20130101) B22F 2301/15 (20130101) B22F 2301/35 (20130101) B22F 2301/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347652 | FAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maohong FAN (Ames, Iowa); Zaixing HUANG (Laramie, Wyoming) |
| ABSTRACT | Embodiments of the present disclosure generally relate to the recovery and extraction of rare earth elements. More specifically, embodiments of the disclosure relate to methods for separating rare earth elements from coal, coal by-product(s), and/or coal-derived product(s). In an embodiment, a method of removing rare earth elements from a coal-derived product is provided. The method generally includes introducing supercritical CO2 to the coal ash to form a first mixture, introducing a first acid to the first mixture to form a second mixture, and removing a first composition from the second mixture, the first composition comprising the one or more rare earth elements. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/316315 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/10 (20200101) Original (OR) Class C01F 17/224 (20200101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/06 (20130101) C22B 3/165 (20130101) C22B 59/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347701 | Cahill et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Timothy Cahill (Livermore, California); Wyatt Du Frane (Livermore, California); Joshua D. Kuntz (Livermore, California); Ryan Lu (Daly City, California); Amy Wat (Oakland, California); Marcus A. Worsley (Hayward, California); Congwang Ye (Livermore, California) |
| ABSTRACT | A composition includes a plurality of microparticles, where the microparticles comprise agglomerates of nanopowder, wherein the nanopowder includes a material selected from the following: a ceramic material, a metal, an alloy, a polymer, or a combination thereof. The microparticles are characterized by having an essentially spherical shape, nanograin features substantially identical to nanograin features of the nanopowder prior to formation into the microparticles, and a nanoscale porosity defined by the nanograin features. The plurality of microparticles have an essentially uniform size relative to one another. Moreover, the composition has flowability having a Hausner Ratio representing tapped density:bulk density less than 1.25. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/315058 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/6269 (20130101) C04B 35/58078 (20130101) Original (OR) Class C04B 35/62222 (20130101) C04B 35/62695 (20130101) C04B 35/63448 (20130101) C04B 2235/528 (20130101) C04B 2235/3813 (20130101) C04B 2235/5436 (20130101) C04B 2235/5454 (20130101) C04B 2235/6026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347719 | Treadwell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LaRico Juan Treadwell (Albuquerque, New Mexico); Clare Davis-Wheeler (Albuquerque, New Mexico) |
| ABSTRACT | A facile solvothermal method can be used to synthesize metal alkanoate nanoparticles using a metal nitrate precursor, alcohol/water, and alkanoic acid. The method can produce lanthanide (e.g., La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, or Yb) and transition metal (e.g., Ag, Co, Cu, or Pb) alkanoate nanoparticles (<100 nm) with spherical morphology. These hybrid nanomaterials adopt a lamellar structure consisting of inorganic metal cation layers separated by an alkanoate anion bilayer and exhibit liquid crystalline phases during melting. For example, thermal analysis indicated the formation of Smectic A liquid crystal phases by lanthanide decanoate nanoparticles, with the smaller lanthanides (Ln=Sm, Gd, Er) displaying additional solid intermediate and Smectic C phases. The formation of liquid crystal phases by the smaller lanthanide ions suggests that these nanoscale materials have vastly different thermal properties than their bulk counterparts, which do not exhibit liquid crystal behavior. Photoluminescence spectroscopy revealed the lanthanide decanoates to be highly optically active, producing strong visible emissions that corresponded to expected electronic transitions by the various lanthanide ions. The metal alkanoate nanoparticles can be calcined to produce metal oxide nanoparticles. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/315497 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 6/001 (20130101) B01J 19/126 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/229 (20200101) Acyclic or Carbocyclic Compounds C07C 51/41 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347838 | ZAMORA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ferring B.V. (Hoofddorp, Netherlands); Brookhaven Science Associates, LLC (Upton, New York) |
| ASSIGNEE(S) | Ferring B.V. (Hoofddorp, Netherlands); Brookhaven Science Associates, LLC (Upton, New York) |
| INVENTOR(S) | Paul O. ZAMORA (Gaithersburg, Maryland); Brent Lee ATKINSON (Highlands Ranch, Colorado); Xinhua LIN (Plainview, New York); Louis A. PENA (Poquott, New York) |
| ABSTRACT | A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 17/443012 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1875 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/12 (20130101) A61L 27/16 (20130101) A61L 27/22 (20130101) A61L 27/24 (20130101) A61L 27/34 (20130101) A61L 27/227 (20130101) A61L 27/507 (20130101) A61L 2430/02 (20130101) Peptides C07K 14/51 (20130101) C07K 14/4705 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347948 | DONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tao DONG (Lakewood, Colorado); Lieve M.L. LAURENS (Denver, Colorado); Philip T. PIENKOS (Lakewood, Colorado); Paris Fabian SPINELLI (Denver, Colorado) |
| ABSTRACT | The present disclosure relates to methods for producing polymers and resins, the method including a first reacting of at least a first diamine with a first carbonate-containing compound and a second carbonate-containing compound to produce at least one of the polymer or the resin, where the first reacting is according to each of R1, R2, R3, and R4 include at least one of a hydrogen atom, a methyl group, a saturated hydrocarbon chain, and/or an unsaturated hydrocarbon chain, and R comprises at least one of a carbon atom, a saturated hydrocarbon chain, and/or an unsaturated hydrocarbon chain. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/382444 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 231/02 (20130101) C07C 237/10 (20130101) C07C 237/20 (20130101) C07C 237/22 (20130101) C07C 269/04 (20130101) C07C 271/16 (20130101) C07C 271/20 (20130101) C07C 279/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 71/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347949 | DONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tao DONG (Lakewood, Colorado); Lieve M.L. LAURENS (Denver, Colorado); Philip T. PIENKOS (Lakewood, Colorado); Paris Fabian SPINELLI (Denver, Colorado) |
| ABSTRACT | The present disclosure relates to methods for producing polymers and resins, the method including a first reacting of at least a first diamine with a first carbonate-containing compound and a second carbonate-containing compound to produce at least one of the polymer or the resin, where the first reacting is according to each of R1, R2, R3, and R4 include at least one of a hydrogen atom, a methyl group, a saturated hydrocarbon chain, and/or an unsaturated hydrocarbon chain, and R comprises at least one of a carbon atom, a saturated hydrocarbon chain, and/or an unsaturated hydrocarbon chain. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/382452 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 231/02 (20130101) C07C 237/10 (20130101) C07C 237/20 (20130101) C07C 237/22 (20130101) C07C 269/04 (20130101) C07C 271/16 (20130101) C07C 271/20 (20130101) C07C 279/12 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 71/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348023 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jifeng Liu (Hanover, New Hampshire); Xiaoxin Wang (Hanover, New Hampshire); Eldred Lee (Hanover, New Hampshire); Can Wu (Lebanon, New Hampshire) |
| ABSTRACT | A selectively-absorbing material includes a silicone polymer and transition-metal oxide nanoparticles dispersed therein. Each of the transition-metal oxide nanoparticles includes manganese. A solar receiver includes (i) a metal substrate including an etched surface having a microroughness between 0.05 micrometers and two micrometers; (ii) a polymer matrix disposed on the etched surface; and (iii) transition-metal oxide nanoparticles dispersed within the polymer matrix. A method for producing transition-metal oxide nanoparticles includes recrystallizing a plurality of two-element nanoparticles at a temperature between 300 and 700° C. The plurality of two-element nanoparticles includes at least two of (i) copper oxide nanoparticles, (ii) manganese oxide nanoparticles, and (iii) iron oxide nanoparticles. A method for fabricating a selective-absorber includes etching a top surface of a metal substrate; depositing a polymer-matrix composite on the etched top surface; and interdiffusing the polymer-matrix composite and the metal substrate. The polymer-matrix composite includes transition-metal oxide nanoparticles dispersed therein. |
| FILED | Tuesday, February 16, 2021 |
| APPL NO | 17/176519 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/02 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/32 (20130101) C09D 7/61 (20180101) C09D 183/04 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/054 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348041 | SIMPSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lin Jay SIMPSON (Lakewood, Colorado); Chaiwat ENGTRAKUL (Louisville, Colorado) |
| ABSTRACT | Described herein are materials and methods useful in the field of insulation, including building materials, refrigeration, cryogenics, and shipping, amongst others. Advantageously, the provided materials and method provide low thermal conductivities and increased mechanical strength, allowing for efficient insulating in a diverse range of applications. The provided materials and methods include individual particles connected by a polymer network that links individual particles and may include hollow or evacuated capsules and various strengthening agents. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314101 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/55 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 133/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348054 | Smartt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heidi A. Smartt (Albuquerque, New Mexico); Dianna S. Blair (Albuquerque, New Mexico); Juan A. Romero (Bayfield, Colorado); Patrick L. Feng (Livermore, California) |
| ABSTRACT | An article that includes a fluorescent composition having at least one of a fluorescent sensor compound and organic reporter molecules encapsulated in a microsphere structure. When encapsulated, the fluorescent sensor compound and the organic reporter molecules are distributed in a liquid organic matrix. When non-encapsulated, the remaining one of the fluorescent sensor compound and the organic reporter molecules reside in the matrix. In response to a force applied to the composition sufficient to break at least a portion of the microsphere structure, the fluorescent sensor compound and the organic reporter molecules are transformed into a non-reversible fluorescent state exhibiting a quantum yield greater than 0.2. The fluorescent state is objectively visually verifiable without physically contacting the composition. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381412 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/07 (20130101) Original (OR) Class C09K 11/54 (20130101) C09K 11/58 (20130101) C09K 11/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348175 | ZHAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Huimin ZHAO (Champaign, Illinois); Mingfeng CAO (Urbana, Illinois); Vinh TRAN (Urbana, Illinois); Zia FATMA (Urbana, Illinois) |
| ABSTRACT | The present disclosure provides polynucleotides and vectors for the genomic engineering and editing of non-conventional yeasts such as Issatchenkia orientalis. The polynucleotides and vectors can be used as tools that are efficient to alter the expression of one or more gene products in the yeast, and specifically to induce the production of organic acids or other bioproducts of interest in the yeast. |
| FILED | Saturday, February 20, 2021 |
| APPL NO | 17/180741 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/815 (20130101) Original (OR) Class C12N 2320/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348201 | SANCHEZ NOGUE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Violeta SANCHEZ NOGUE (Manlleu, Spain); Eric M. KARP (Denver, Colorado); Patrick Owen SABOE (Golden, Colorado) |
| ABSTRACT | The present disclosure relates to a method that includes utilizing a microorganism for the converting of a substrate to an acid contained in a mixture that includes the acid and water, maintaining a pH of the mixture to less than 5, and treating the mixture with a first stream comprising an organic. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306251 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/40 (20130101) Original (OR) Class C12P 7/52 (20130101) C12P 7/54 (20130101) C12P 39/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348212 | Fozouni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Parinaz Fozouni (San Francisco, California); Melanie Ott (Mill Valley, California); Jennifer A. Doudna (Oakland, California) |
| ABSTRACT | The present disclosure relates to methods using CRISPR-Cas13a enzyme, complexed with HIV or HCV crRNAs to specifically and sensitively detect and quantify the presence of HIV or HCV RNA in a sample. These methods can be used to diagnose HIV or HCV infection, quantify the concentration of HIV or HCV RNA present in a sample, identify the presence of different HIV or HCV splice variants, subtypes, or mutations, and to monitor reactivation of HIV or HCV transcription. |
| FILED | Friday, September 06, 2019 |
| APPL NO | 17/273752 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/703 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6888 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348517 | Croteau et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul F. Croteau (Columbia, Connecticut); John E. Holowczak (Windsor, Connecticut); Thomas J. Martin (East Hampton, Connecticut); Paul Attridge (Colchester, Connecticut) |
| ABSTRACT | An airfoil includes an airfoil section that has an airfoil wall that surrounds a cavity. The airfoil wall includes a first wall section comprised of a monolithic ceramic shell, a second wall section comprised of a CMC liner that is bonded along an interface to an interior side of the monolithic ceramic shell, and a ceramic barrier coating that is bonded to an exterior side of the monolithic ceramic shell. The airfoil wall includes at least one of: inter-section cooling channels that extend along the interface and are bounded by the monolithic ceramic shell and the CMC liner, or intra-section cooling channels that extend within the CMC liner. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 16/870310 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/02 (20130101) F01D 9/065 (20130101) Original (OR) Class F01D 25/12 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/12 (20130101) F05D 2300/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348790 | Adetola et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARRIER CORPORATION (Palm Beach Gardens, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Veronica Adetola (West Hartford, Connecticut); Fu Lin (Glastonbury, Connecticut); Hayden M. Reeve (West Hartford, Connecticut) |
| ABSTRACT | A supervisory-level control system is provided and includes a summation unit receptive of first and second signals, an HVAC system to generate the second signal according to first set-point signals and to a second set-point signal and a supervisory controller. The supervisory controller includes a control unit, a set-point scheduler and a zone level set-point distribution unit. The control unit is receptive of an error signal representing a difference between the first and second signals from the summation unit. The set-point scheduler is receptive of a demand signal generated by the control unit according to the error signal. The set-point scheduler generates a set-point command signal and the second set-point signal according to the demand signal. The zone level set-point distribution unit is configured to generate the first set-point signals in accordance with the set-point command signal. |
| FILED | Tuesday, November 12, 2019 |
| APPL NO | 17/057190 |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/46 (20180101) Original (OR) Class F24F 11/54 (20180101) F24F 11/63 (20180101) F24F 2140/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348971 | Sweeney et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel C. Sweeney (Oak Ridge, Tennessee); Christian M. Petrie (Oak Ridge, Tennessee); Adrian M. Schrell (Oak Ridge, Tennessee) |
| ABSTRACT | A system and method for determining an object characteristic from a timed sequence of measured characteristics wherein the object characteristic is determined based on a comparison of a current measured characteristic against a variable reference characteristic. The variable reference characteristic is selected by iterating through the timed sequenced and determining a separate quality metric for the current measured characteristic against each earlier measured characteristic and selecting the variable reference as a function of the determined quality metrics. In one embodiment, iteration continues only until an earlier measured characteristics is found with a quality metric that meets or exceeds a threshold value. In another embodiment, iteration continues through a plurality of earlier measured characteristic (perhaps all) and the variable reference is selected as the earlier measured characteristic with the highest quality metric. The measured characteristics may include OFDR measurements. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306113 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/35358 (20130101) G01D 5/35393 (20130101) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/3206 (20130101) Original (OR) Class G01K 2007/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349040 | Miller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Erin A. Miller (Richland, Washington); Richard E. Jacob (Kennewick, Washington); Nikhil S. Deshmukh (Everett, Washington); Cynthia L. Warner (Richland, Washington); Richard S. Wittman (Richland, Washington); Luke W. Campbell (Richland, Washington); Dustin M. Kasparek (Richland, Washington); Andy Gilbert (Richland, Washington); Stanley L. Owsley, JR. (Pasco, Washington); Kurt L. Silvers (Pasco, Washington); Mital A. Zalavadia (Richland, Washington) |
| ABSTRACT | Method include emitting x-rays from an x-ray source, directing a first portion of the x-rays through an object grating situated adjacent to an object while the object is scanned relative to the object grating along a scan direction, directing a second portion of the x-rays through the object and subsequently through a detector grating without transmitting through the object grating, wherein the object grating and detector grating are adjacently arranged in a field of view of the x-rays sequentially with respect to each other in the scan direction, and receiving the first portion transmitted through the object and object grating with a first portion of a detector and receiving the second portion transmitted through the object and the detector grating with a second portion of the detector adjacent to the first portion of the detector. Systems are also disclosed, along with related techniques for beam hardening correction. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/322635 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/06 (20130101) A61B 6/484 (20130101) A61B 6/4035 (20130101) A61B 6/4291 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/10 (20130101) G01N 23/18 (20130101) G01N 23/041 (20180201) Original (OR) Class G01N 23/083 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349065 | MASOUDI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EMISSOL LLC (Mill Creek, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mansour MASOUDI (Mill Creek, Washington); Edward Benjamin TEGELER, IV (Shoreline, Washington); Jacob Roy HENSEL (Bothel, Washington) |
| ABSTRACT | A capture device comprising a capture device substrate with non-linear flow channels, a method of manufacturing the capture device and a method of using the capture device including to capture CO2 from the air is disclosed. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317819 |
| CURRENT CPC | Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 1/002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/02 (20130101) G01N 33/004 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210350041 | Lepley |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Benjamin Lepley (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Lepley (Tucson, Arizona) |
| ABSTRACT | Systems and methods for automating design of photovoltaic installations for placement on a selected site receive geographical information describing the site that includes areas of the site which must be spanned by support structures carrying photovoltaic panels such as canals, trenches, roads, arenas, and other features. An initial structure design which meets supplied requirements for energy production and as well as economic constraints is produced using elements produced by varying characteristics of predefined template structures. Genetic optimization of the initial design is performed to optimize dimensions of the structural elements and structural material choices to produce a structure that optimizes a fitness metric such as the levelized cost of energy. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/189046 |
| CURRENT CPC | Meteorology G01W 1/12 (20130101) Electric Digital Data Processing G06F 16/245 (20190101) G06F 30/13 (20200101) Original (OR) Class G06F 30/27 (20200101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0875 (20130101) G06Q 10/06313 (20130101) G06Q 50/08 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/10 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210350236 | Severa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Mark Severa (Albuquerque, New Mexico); Craig Michael Vineyard (Cedar Crest, New Mexico); Ryan Anthony Dellana (Albuquerque, New Mexico); Abrar Anwar (Rosenberg, Texas) |
| ABSTRACT | A method of increasing neural network robustness. The method comprises defining an artificial neural network comprising a number of bounded ramp activation functions. The network is trained iteratively in a layer-by-layer fashion. Each iteration increases the slope of the activation functions toward a discrete threshold activation and stops when the activation functions converge to the threshold activation and the network exhibits spiking behavior. Alternatively, weight agnostic neural networks are created, wherein nodes in the networks comprise fixed shared weights. A subset of networks is identified that comprise activation functions compatible with neuromorphic hardware and are tested with a specified number of shared weight values. A score is generated for each combination of network and weight value according to performance and mapping to neuromorphic hardware, and the networks are ranked. The networks are then combined according to ranking to create a new network that exhibits spiking behavior. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314751 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/623 (20130101) G06K 9/6262 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/049 (20130101) G06N 3/063 (20130101) G06N 3/0454 (20130101) G06N 3/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210350950 | SIMPSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lin Jay SIMPSON (Lakewood, Colorado); Chaiwat ENGTRAKUL (Louisville, Colorado) |
| ABSTRACT | Described herein are materials and methods useful in the field of insulation, including building materials, refrigeration, cryogenics, and shipping, amongst others. Advantageously, the provided materials and method provide reduced radiative heat transfer by applying coatings to insulating materials in order to alter the emissivity, including in the infrared electromagnetic spectrum. Advantageously, the provided materials and methods, while increasing thermal conductivity, provide an overall reduction in heat transfer and therefore provide superior insulation. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314548 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/125 (20130101) H01B 1/127 (20130101) H01B 1/128 (20130101) H01B 3/087 (20130101) Original (OR) Class H01B 17/64 (20130101) H01B 19/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210350957 | TAKAYASU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Brookhaven Technology Group, Inc. (Stony Brook, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Makoto TAKAYASU (Lexington, Massachusetts); Vyacheslav SOLOVYOV (Rocky Point, New York) |
| ABSTRACT | A structure and method provide cables of high-temperature superconducting flat tape and/or filament wires, with a small bending diameter. A cable has a former having cross section that includes a rectangle having rounded ends (i.e. an obround), and the flat tape is wound around the surface of the former at an angle to minimize bending. The former surface may have raised helical ribs or lowered grooves to provide tape registration in multi-layer configurations. Tape may be wound from a spool onto the former under tension, and cut with a laser cutter to produce fine filaments immediately before winding. The former may be slit longitudinally to prevent loop eddy currents and reduce AC losses. The wound cable may be jacketed to provide a cable-in-conduit conductor (CICC), and coolant channels may be provided in the jacket or in the former. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245863 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 12/06 (20130101) H01B 12/08 (20130101) Original (OR) Class H01B 12/16 (20130101) H01B 13/282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210351003 | Garimella et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Sandilya V.B. Garimella (Richland, Washington); Yehia M. Ibrahim (West Richland, Washington); Ailin Li (Richland, Washington); Richard D. Smith (Richland, Washington) |
| ABSTRACT | Methods include directing a group of ions through a separation region of an ion manipulation apparatus, separating the group of ions in the separation region based on ion mobility, selecting a subset of the group of ions based on a dependence between ion mobility and ion arrival time of the separated ions at a deposition switch of the ion manipulation apparatus, and depositing the selected subset of ions on a substrate. Related systems and ion manipulation apparatus are disclosed. Also disclosed are methods and system that provide concurrent ion accumulation and ion separation in coupled and switchable electrode regions using traveling wave electric fields. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314928 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) Electric Discharge Tubes or Discharge Lamps H01J 27/022 (20130101) H01J 37/3007 (20130101) H01J 37/3178 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210351404 | Xiao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Jie Xiao (Richland, Washington); Yujing Bi (Richland, Washington) |
| ABSTRACT | Methods for synthesizing single crystalline Ni-rich cathode materials are disclosed. The Ni-rich cathode material may have a formula LiNiXMnyMzCo1-x-y-zO2, where M represents one or more dopant metals, x≥0.6, 0.01≤y<0.2, 0≤z≤0.05, and x+y+z≤1.0. The methods are cost-effective, and include methods for solid-state, molten-salt, and flash-sintering syntheses. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 16/951868 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/50 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210351787 | KAYIRAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ADVANCED MICRO DEVICES, INC. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ONUR KAYIRAN (FAIRPORT, New York); STEVEN RAASCH (BOXBOROUGH, Massachusetts); SERGEY BLAGODUROV (BELLEVUE, Washington); JAGADISH B. KOTRA (AUSTIN, Texas) |
| ABSTRACT | Temporal link encoding, including: identifying a data type of a data value to be transmitted; determining that the data type is included in one or more data types for temporal encoding; and transmitting the data value using temporal encoding. |
| FILED | Thursday, May 07, 2020 |
| APPL NO | 16/869207 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 7/3073 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 27/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210346251 | Subramaniam |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anand Bala Subramaniam (Merced, California) |
| ABSTRACT | Methods and compositions for rapid and efficient assembly of substrates (e.g., fibers) coated with lamellar vesicles are provided, wherein the vesicles are more strongly attached to the substrate than those made using other methods. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307269 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/14 (20130101) Original (OR) Class A61K 8/20 (20130101) A61K 8/553 (20130101) A61K 8/731 (20130101) A61K 8/8117 (20130101) A61K 47/02 (20130101) A61K 47/24 (20130101) A61K 47/32 (20130101) A61K 47/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346495 | ESSER-KAHN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| INVENTOR(S) | Aaron ESSER-KAHN (Chicago, Illinois); Brittany MOSER (Chicago, Illinois) |
| ABSTRACT | The current disclosure describes the use of NFkB inhibitors as immune potentiators in vaccine compositions comprising adjuvants. Accordingly, aspects of the disclosure relate to a method for vaccinating a subject comprising administering a NFkB inhibitor and an adjuvant (or a composition of the disclosure comprising NFkB and an adjuvant) to the subject. Further aspects relate to a method for inhibiting an inflammatory reaction associated with an adjuvant in a subject, the method comprising co-administering a NFkB inhibitor and an adjuvant (or a composition of the disclosure comprising NFkB and an adjuvant) to the subject. Yet further aspects relate to a pharmaceutical composition comprising a NFkB inhibitor and an adjuvant. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337610 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/09 (20130101) A61K 31/085 (20130101) A61K 31/165 (20130101) A61K 38/1825 (20130101) A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 39/145 (20130101) A61K 2039/55561 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 31/12 (20180101) A61P 37/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346582 | Friedberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); University of Maryland, College Park (Collega Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Friedberg (Baltimore, Maryland); Hosam Fathy (Kensington, Maryland); Jin-Oh Hahn (Potomac, Maryland); Mahsa Doosthosseini (Laurel, Maryland); Majid Aroom (Preston, Maryland); Kevin Aroom (Silver Spring, Maryland) |
| ABSTRACT | Systems and methods for gas exchange in a patient are provided that use an external circuit to cause oxygenation perfusion in a patient's body cavity (such as the abdomen) using an inert chemical (e.g., perfluorocarbon), independent of the lungs. The external circuit includes components configured to control properties of the chemical, including temperature, flow rate, pressure, oxygenation percentage, carbon dioxide percentage. The system also includes safety features to reduce the likelihood of injury to the patient. Each of the safety features and chemical properties can be controlled by a healthcare worker, such as a physician, nurse, or emergency operator, for a particular patient. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308567 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/28 (20130101) Original (OR) Class A61M 1/369 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347046 | WANDZEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arthur Richard WANDZEL (Orchard Lake, Michigan); Stefanie TELLEX (Providence, Rhode Island) |
| ABSTRACT | A system and method of operating a mobile robot to perform tasks includes representing a task in an Object-Oriented Partially Observable Markov Decision Process model having at least one belief pertaining to a state and at least one observation space within an environment, wherein the state is represented in terms of classes and objects and each object has at least one attribute and a semantic label. The method further includes receiving a language command identifying a target object and a location corresponding to the target object, updating the belief associated with the target object based on the language command, driving the mobile robot to the observation space identified in the updated belief, searching the updated observation space for each instance of the target object, and providing notification upon completing the task. In an embodiment, the task is a multi-object search task. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 17/280365 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1661 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347718 | Chu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNIVERSITY OF NORTH DAKOTA (Grand Forks, North Dakota) |
| ASSIGNEE(S) | University of North Dakota (Grand Forks, North Dakota) |
| INVENTOR(S) | Qianli Chu (Grand Forks, North Dakota); Zhihan Wang (Grand Forks, North Dakota) |
| ABSTRACT | A method of making cyclobutane-1,2-diacid building blocks includes using trans-cinnamic acid in its beta form (head to head packing) and photodimerizing the trans-cinnamic acid to create cis-cyclobutane-1,2-dicarboxylic acid (CBDA4). |
| FILED | Monday, November 25, 2019 |
| APPL NO | 17/283873 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 51/353 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347792 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Florida State University Research Foundation, Inc. (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Biwu Ma (Tallahassee, Florida); Yu Tian (Tallahassee, Florida) |
| ABSTRACT | Metal halide perovskite crystals, composite materials that include metal halide perovskite crystals and a polymeric matrix material, devices that include metal halide perovskite crystals, and methods of forming metal halide perovskite crystals, composite materials, and devices. The devices may include optoelectronic devices, such as light-emitting diodes. The light-emitting diodes may emit red light. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380904 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/005 (20130101) C07F 7/003 (20130101) C07F 7/24 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0037 (20130101) H01L 51/0072 (20130101) H01L 2251/308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348142 | Barnes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DNA POLYMERASE TECHNOLOGY, INC. (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne M. Barnes (University City, Missouri); Milko B. Kermekchiev (St. Louis, Missouri); Zhian Zhang (Ballwin, Missouri) |
| ABSTRACT | Provided are mutant polymerases having DNA polymerase activity and reverse transcriptase activity or strand displacement activity, along with target nucleic acid amplification methods employing such mutant polymerases. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/303445 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1252 (20130101) Original (OR) Class C12N 9/1276 (20130101) C12N 15/1096 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6846 (20130101) C12Q 2521/101 (20130101) C12Q 2531/101 (20130101) C12Q 2531/119 (20130101) Enzymes C12Y 207/07007 (20130101) C12Y 207/07049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348177 | RON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mily RON (Davis, California); Neelima R. SINHA (Davis, California); Anne B. BRITT (Davis, California); Moran FARHI (Davis, California) |
| ABSTRACT | Methods and compositions for selecting plants with targeted nuclease alterations are provided. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 17/272874 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/8203 (20130101) Original (OR) Class C12N 15/8207 (20130101) C12N 15/8213 (20130101) C12N 2310/20 (20170501) C12N 2770/00043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348218 | SARDAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY COPORATION (Indianapplis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajesh SARDAR (Avon, Indiana); Thakshila LIYANAGE (Indianapolis, Indiana); Adrianna MASTERSON (Indianapolis, Indiana); Hristos Z. KAIMAKLIOTIS (Zionsville, Indiana) |
| ABSTRACT | Biosensors and methods for localized surface plasmon resonance biosensing are disclosed. The biosensor can include a substrate having a substrate surface to which a plurality of localized surface plasmon resonance (LSPR) antennae are affixed. The LSPR antennae can be affixed via an affixation surface of the LSPR antenna. The LSPR antennae can have a functional surface opposite the affixation surface. Each functional surface can be functionalized by a plurality of single-stranded DNA. |
| FILED | Tuesday, October 22, 2019 |
| APPL NO | 17/283977 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348289 | Kulinsky et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lawrence Kulinsky (Irvine, California); Tuo Zhou (Irvine, California) |
| ABSTRACT | The present invention is directed to devices and methods for assembling particulates through the use of non-contact electrokinetic forces applied to polymeric, organic, non-organic, and metallic micro- and nano-particulates in an aqueous solution. The present invention features an electrode comprising a conductive substrate with a layer of photosensitive polymer disposed on it with a plurality of windows etched into the layer. The plurality of windows expose certain portions of the conductive substrate. Applying electric signals to the conductive substrate (e.g. by a function generator) causes materials to attract to only the exposed portions of the conductive substrate. The materials may comprise a plurality of organic, non-organic, and metallic micro- and nano-particulates disposed in an aqueous solution. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/314708 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348292 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| INVENTOR(S) | Jeffrey Ma (Fort Collins, Colorado); Amy L. Prieto (Fort Collins, Colorado) |
| ABSTRACT | A method for electrodeposition of pure phase crystalline SnSb from deep eutectic ethaline is described. Thin films of SnSb were synthesized using a solution containing equimolar Sn(II) and Sb(III) chlorides as precursors, and ethaline (1:2 by weight of choline chloride and ethylene chloride) was used as the solvent for the electrodeposition solution. The purity of the product is important, as the impure phase is found to be detrimental to the material's lifetime as both a sodium-ion and a lithium-ion anode. For sodium-ions, the directly deposited electrode was able to retain 95% capacity after 300 cycles, and only fall below 80% capacity retention after 800 cycles when cycled versus sodium. The electrodeposited SnSb used as a Li-ion battery anode showed stability, only failing below 80% capacity retention after 400 cycles. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317562 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/30 (20130101) Original (OR) Class C25D 3/34 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) H01M 4/387 (20130101) H01M 4/0452 (20130101) H01M 10/36 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349012 | Styczynski et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Styczynski (Atlanta, Georgia); Monica P. McNerney (Atlanta, Georgia) |
| ABSTRACT | Disclosed herein are systems and methods for quantifying analytes in a desired complex solution with minimal inter-sample variability. The invention includes methods and diagnostic tools for quantifying analytes in aqueous solutions or biological fluid samples with sample-specific calibration and colorimetric or detectable output. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 17/273728 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) G01N 21/272 (20130101) Original (OR) Class G01N 33/52 (20130101) G01N 33/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349127 | Coe et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Angela Coe (Tenstrike, Minnesota); Guohong Li (Highland Park, New Jersey); Eva Y. Andrei (Highland Park, New Jersey) |
| ABSTRACT | An apparatus, including: a scanning probe microscope head with a frame configured to fit within an insert of a cryostat, and a scanner, a probe and a sample holder all disposed within the frame; and a coarse motor assembly disposed within the frame and comprising: a positionable component; and coarse motors. The coarse motors are configured to move the positionable component relative to the frame along an X axis, a Y axis, and a Z axis. The apparatus further includes a universal electrical base connection with half of a plug/socket arrangement. The plug/socket arrangement is configured to provide electrical communication between the scanning probe microscope head and a base which has a second half of the plug/socket arrangement when the scanning probe microscope head is lowered onto the base. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313743 |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 10/02 (20130101) G01Q 30/20 (20130101) G01Q 70/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349723 | HU et al. |
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| FUNDED BY |
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| APPLICANT(S) | DEEPBITS TECHNOLOGY INC. (Riverside, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | DEEPBITS TECHNOLOGY INC. (Riverside, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Xunchao HU (Riverside, California); Sheng YU (Riverside, California); Heng YIN (Riverside, California) |
| ABSTRACT | The present invention performs high-throughput disassembly for executable code comprising a plurality of instructions. An input of the executable code is received. Exhaustive disassembly is performed on the executable code to produce a set of exhaustively disassembled instructions. An instruction flow graph is constructed from the exhaustively disassembled instructions. Instruction embedding is performed on the exhaustively disassembled instructions to construct embeddings. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/243570 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/53 (20130101) G06F 9/3838 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349945 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Zhikang Zhang (Mesa, Arizona); Fengbo Ren (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Zhikang Zhang (Mesa, Arizona); Fengbo Ren (Tempe, Arizona) |
| ABSTRACT | A data-driven nonuniform subsampling approach for computation-free on-sensor data dimensionality is provided, referred to herein as selective sensing. Designing an on-sensor data dimensionality reduction scheme for efficient signal sensing has long been a challenging task. Compressive sensing is a generic solution for sensing signals in a compressed format. Although compressive sensing can be directly implemented in the analog domain for specific types of signals, many application scenarios require implementation of data compression in the digital domain. However, the computational complexity involved in digital-domain compressive sensing limits its practical application, especially in resource-constrained sensor devices or high-data-rate sensor devices. Embodiments described herein provide a selective sensing framework that adopts a novel concept of data-driven nonuniform subsampling to reduce the dimensionality of acquired signals while retaining the information of interest in a computation-free fashion. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317372 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/901 (20190101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6232 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349998 | Hempstead et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Hempstead (Boston, Massachusetts); David Werner (Boston, Massachusetts); Eric Miller (Boston, Massachusetts); Kyle Juretus (Philadelphia, Pennsylvania); Ioannis Savadis (Philadelphia, Pennsylvania) |
| ABSTRACT | In some embodiments, the present disclosure provides systems and methods for detecting malware, including receiving thermal images of an integrated circuit, and generating a power density profile using at least one of the thermal images. The present disclosure further includes comparing the power density profile to an expected power density profile of the integrated circuit, and determining, based on the comparison, if the integrated circuit is in an abnormal operating state. |
| FILED | Monday, October 07, 2019 |
| APPL NO | 17/250973 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/566 (20130101) Original (OR) Class G06F 21/567 (20130101) G06F 21/755 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210350242 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yixing Li (Tempe, Arizona); Fengbo Ren (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Yixing Li (Tempe, Arizona); Fengbo Ren (Tempe, Arizona) |
| ABSTRACT | Various embodiments of a system and method for pruning binary neural networks by analyzing weight flipping frequency and pruning the binary neural network based on the weight flipping frequency associated with each channel of the binary neural network are disclosed herein. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317300 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/082 (20130101) Original (OR) Class G06N 3/0472 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210350725 | Park et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clara Park (Cambridge, Massachusetts); Xuanhe Zhao (Cambridge, Massachusetts); Hyunwoo Yuk (Cambridge, Massachusetts); Christopher Tam Nguyen (Cambridge, Massachusetts); Ellen T. Roche (Cambridge, Massachusetts) |
| ABSTRACT | A biorobotic hybrid heart that preserves organic intracardiac structures and mimics cardiac motion by image-guided replication of the cardiac myofiber architecture of the left ventricle with an active synthetic myocardium that drives the motion of the heart. The active soft tissue mimic is adhered to the organic endocardial tissue in a helical fashion using a custom-designed adhesive to form a flexible, conformable, and watertight organosynthetic interface. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193910 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/08 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/32 (20130101) Original (OR) Class G09B 23/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210351312 | LUNT, III et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Richard R. LUNT, III (Williamston, Michigan); Chenchen YANG (Holt, Michigan) |
| ABSTRACT | A solar concentrator device is provided. The solar concentrator device includes a waveguide having a luminophore and a first refractive index; a photovoltaic component operably coupled to the waveguide; and a film disposed onto a surface of the waveguide, the film having a second refractive index. The second refractive index of the film is lower than the first refractive index of the waveguide. The waveguide and the film are visibly transparent. |
| FILED | Monday, September 23, 2019 |
| APPL NO | 17/277807 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 8/003 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/40 (20180101) C09J 2203/322 (20130101) C09J 2203/354 (20200801) Optical Elements, Systems, or Apparatus G02B 6/0003 (20130101) G02B 6/0025 (20130101) G02B 6/0065 (20130101) G02B 6/0076 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/055 (20130101) H01L 31/0543 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210351427 | Li |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yat Li (Fremont, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yat Li (Fremont, California) |
| ABSTRACT | A wastewater to chemical fuel conversion device is provided that includes a housing having a first chamber and a second chamber, where the first chamber includes a bio-photoanode, where the second chamber includes a photocathode, where a backside of the bio-photoanode abuts a first side of a planatized fluorine doped tin oxide (FTO) glass, where a backside of the photocathode abuts a second side of the FTO glass, where a proton exchange membrane separates the first chamber from the second chamber, where the first chamber includes a wastewater input and a reclaimed water output, where the second chamber includes a solar light input and a H2 gas output, where the solar light input is disposed for solar light illumination of the first chamber and the second chamber. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 16/868380 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/30 (20130101) C02F 1/725 (20130101) C02F 3/005 (20130101) C02F 2305/10 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/003 (20130101) C25B 1/04 (20130101) C25B 11/035 (20130101) C25B 11/0405 (20130101) C25B 11/0415 (20130101) C25B 11/0452 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210351720 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Wenzhuo Wu (West Lafayette, Indiana); Ruoxing Wang (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to a novel triboelectric nanogenerator comprising a novel polyvinyl alcohol (PVA)-based biocompatible polymer. The novel polyvinyl alcohol-based biocompatible polymer comprises a blending product of a mixture comprising a polyvinyl alcohol, a gelatin, and an optional salt. The polyvinyl alcohol-based biocompatible polymer is a substantially transparent film. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/190464 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02405 (20130101) Compositions of Macromolecular Compounds C08L 29/04 (20130101) C08L 89/06 (20130101) C08L 2203/02 (20130101) C08L 2203/20 (20130101) Electric Machines Not Otherwise Provided for H02N 1/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210352053 | MELODIA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tommaso MELODIA (Newton, Massachusetts); Leonardo BONATI (Boston, Massachusetts); Salvatore D'ORO (Allston, Massachusetts); Francesco RESTUCCIA (Boston, Massachusetts) |
| ABSTRACT | A steganographic communication system and method are provided. A covert packet generator can embed a stream of covert data as covert data symbols within primary I/Q symbols of a primary data stream in a covert packet. The covert packet has a data structure having a header, a payload, and a payload error detecting code. The header includes information on how to demodulate the covert packet by a receiver. The covert packet generator can also determine if a number of primary I/Q symbols is large enough to generate the header and can generate displacements in the primary I/Q symbols in a constellation diagram randomly in a plurality of transmissions to mimic channel noise. A transmitter and receiver can provide mutual authentication for covert transmissions. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/316773 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0048 (20130101) H04L 5/0055 (20130101) H04L 63/0428 (20130101) Original (OR) Class H04L 63/1475 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210346251 | Subramaniam |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anand Bala Subramaniam (Merced, California) |
| ABSTRACT | Methods and compositions for rapid and efficient assembly of substrates (e.g., fibers) coated with lamellar vesicles are provided, wherein the vesicles are more strongly attached to the substrate than those made using other methods. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307269 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/14 (20130101) Original (OR) Class A61K 8/20 (20130101) A61K 8/553 (20130101) A61K 8/731 (20130101) A61K 8/8117 (20130101) A61K 47/02 (20130101) A61K 47/24 (20130101) A61K 47/32 (20130101) A61K 47/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347046 | WANDZEL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arthur Richard WANDZEL (Orchard Lake, Michigan); Stefanie TELLEX (Providence, Rhode Island) |
| ABSTRACT | A system and method of operating a mobile robot to perform tasks includes representing a task in an Object-Oriented Partially Observable Markov Decision Process model having at least one belief pertaining to a state and at least one observation space within an environment, wherein the state is represented in terms of classes and objects and each object has at least one attribute and a semantic label. The method further includes receiving a language command identifying a target object and a location corresponding to the target object, updating the belief associated with the target object based on the language command, driving the mobile robot to the observation space identified in the updated belief, searching the updated observation space for each instance of the target object, and providing notification upon completing the task. In an embodiment, the task is a multi-object search task. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 17/280365 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/1661 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348560 | Dai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongtao Dai (West Hartford, Connecticut); Lance L. Smith (West Hartford, Connecticut); Jeffrey M. Cohen (Hebron, Connecticut) |
| ABSTRACT | A combustor assembly for a gas turbine engine according to an example of the present disclosure includes, among other things, a combustion chamber, and a fuel injector assembly in communication with the combustion chamber that has a swirler body situated about a nozzle to define an injector passage that converges to a throat. The throat is defined at a distance from the combustion chamber. The nozzle includes a primary fuel injector and an array of secondary plain jet fuel injectors. |
| FILED | Tuesday, March 02, 2021 |
| APPL NO | 17/189334 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) F02C 7/222 (20130101) Original (OR) Class F02C 9/26 (20130101) Jet-propulsion Plants F02K 3/06 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) Methods or apparatus for combustion using fluid fuel or Solid Fuel Suspended In Air F23C 7/004 (20130101) Burners F23D 11/383 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/14 (20130101) F23R 3/26 (20130101) F23R 3/28 (20130101) F23R 3/286 (20130101) F23R 3/343 (20130101) F23R 3/346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210352496 | Barsoum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Constellation Designs, LLC (Anaheim, California) |
| ASSIGNEE(S) | Constellation Designs, LLC (Anaheim, California) |
| INVENTOR(S) | Maged F. Barsoum (San Jose, California); Christopher R. Jones (Pacific Palisades, California) |
| ABSTRACT | Communication systems are described that use unequally spaced constellations that have increased capacity compared to conventional constellations operating within a similar SNR band. One embodiment is a digital communications system including a transmitter transmitting signals via a communication channel, the transmitter including a coder capable of receiving user bits and outputting encoded bits at a rate, a mapper capable of mapping encoded bits to symbols in a constellation, and a modulator capable of generating a modulated signal for transmission via the communication channel using symbols generated by the mapper, wherein the constellation is unequally spaced and characterizable by assignment of locations and labels of constellation points to maximize parallel decode capacity of the constellation at a given signal-to-noise ratio so that the constellation provides a given capacity at a reduced signal-to-noise ratio compared to a uniform constellation that maximizes the minimum distance between constellation points of the uniform constellation. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/325170 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 13/255 (20130101) H03M 13/6325 (20130101) Transmission H04B 15/00 (20130101) H04B 17/336 (20150115) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0003 (20130101) H04L 1/0009 (20130101) H04L 27/3405 (20130101) H04L 27/3483 (20130101) H04L 27/3809 (20130101) Wireless Communication Networks H04W 24/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20210345917 | Carr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Ressearch Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Russell Carr (Ames, Iowa); Nigel Forest Reuel (Ames, Iowa) |
| ABSTRACT | The present disclosure provides a resonator system for detecting perspiration. The system includes a resonator. The resonator includes an electronically conductive segment. The resonator further includes a polymeric component coating at least a portion of the electronically conductive segment. The resonator further includes a fluidic channel component positioned adjacent to the polymeric component and comprising a microfluidic channel. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/220393 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/6804 (20130101) A61B 5/14517 (20130101) A61B 5/14546 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/022 (20130101) G01N 29/036 (20130101) G01N 29/222 (20130101) G01N 33/487 (20130101) G01N 2291/0228 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210348905 | Yen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Chian-Fong Yen (Lansdale, Pennsylvania); Ashiq A. Quabili (Havre De Grace, Maryland); Chih-Tsai Chen (Moorestown, New Jersey); Nelson Carey (Cape May, New Jersey); Robert P. Kaste (North East, Maryland); Patrick O'Connor (Galloway Twp, New Jersey); Jian H. Yu (Belcamp, Maryland) |
| ABSTRACT | An explosive threat mitigation unit (TMU) stands ready to receive a suspected bomb, enclose it, and contain the explosion if one occurs. An operator protects bystanders and surroundings by putting the suspected bomb in a TMU and then closing the TMU. If the bomb goes off, the TMU mitigates the effects of both the blast and the fragments. One variation has a container, a tube, a cap, and a door. The container includes an opening. The tube, arranged in the container, aligns with the opening. The cap slides through the opening and over the tube. The door slides into place to close the opening and enclose the cap within the container. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380744 |
| CURRENT CPC | Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 21/0233 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/0471 (20130101) Blasting F42D 5/045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210350045 | Ashok et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Amit Ashok (Tucson, Arizona); James Liang Chih Huang (Gainesville, Florida) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Amit Ashok (Tucson, Arizona); James Liang Chih Huang (Gainesville, Florida) |
| ABSTRACT | Apparatus and methods are disclosed for providing virtual bags that can be used to simulate and quantify performance of different explosive detection system architectures. The virtual bags can be provided to a simulator for designing and simulating operation of imaging scanners, including X-ray and millimeter-wave based threat detection equipment deployed in transit facilities and other secure locations. One example method of generating container models for a container inspection system includes generating a plurality of objects using a probability function; generating a respective position, scale, and orientation for each of the objects within a container having a defined boundary; generating pairings for a respective material for each of the objects using a probability function; and storing a container instance indicating at least one of: the generated pairings, the respective object positions, object scales, object orientation, the objects, or the respective materials in a computer-readable storage device. |
| FILED | Tuesday, October 15, 2019 |
| APPL NO | 17/286425 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/2076 (20130101) G01N 23/20008 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/005 (20130101) Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class G06F 2111/08 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6226 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210345910 | PEARLMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPT. OF VETERANS AFFAIRS (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPT. OF VETERANS AFFAIRS (WASHINGTON, District of Columbia) |
| INVENTOR(S) | JONATHAN L. PEARLMAN (PITTSBURGH, Pennsylvania); RORY A. COOPER (GIBSONIA, Pennsylvania); JONATHAN A. DUVALL (PITTSBURGH, Pennsylvania); ANAND A. MHATRE (PITTSBURGH, Pennsylvania) |
| ABSTRACT | A load cell apparatus for use with a bed includes a housing having a top portion and a bottom portion, and a load cell device held by the bottom portion of the housing. The load cell device is structured to generate a signal having a magnitude that is proportional to a first force being applied to the load cell device. The load cell apparatus also includes a button member held by the housing in a manner wherein the button member is structured to engage the load cell device and apply the first force to the load cell device in response to a second force being applied to the top portion of the housing. Also, various systems for monitoring parameters such as weight, sleep quality, fall risk, and/or pressure sore risk that may incorporate such a load cell apparatus. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381354 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/002 (20130101) A61B 5/117 (20130101) A61B 5/447 (20130101) A61B 5/1036 (20130101) Original (OR) Class A61B 5/1115 (20130101) A61B 5/1117 (20130101) A61B 5/4815 (20130101) A61B 5/6891 (20130101) A61B 5/6892 (20130101) A61B 5/7275 (20130101) A61B 2560/0214 (20130101) A61B 2562/166 (20130101) A61B 2562/0252 (20130101) A61B 2562/0261 (20130101) Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 7/0527 (20161101) A61G 2203/44 (20130101) Weighing G01G 19/445 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/26 (20130101) G01L 1/2206 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210346408 | Cynamon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paratek Pharmaceuticals, Inc. (King Of Prussia, Pennsylvania); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Henry Cynamon (Dewitt, New York); Michael P. Draper (Windham, New Hampshire); Judith N. Steenbergen (Newtown, Pennsylvania); S. Ken Tanaka (Bellevue, Washington) |
| ABSTRACT | The present invention provides methods of treating mycobacterial infections or mycobacterial diseases by administering a tetracycline compound, e.g., omadacycline, or a pharmaceutically acceptable salt thereof. |
| FILED | Tuesday, September 03, 2019 |
| APPL NO | 17/273034 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/65 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210347734 | Mallipattu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia); Icahn School of Medicine at Mount Sinai (New York, New York); The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sandeep Mallipattu (St. James, New York); Bhaskar Das (West Nyack, New York) |
| ABSTRACT | The present disclosure is concerned with small molecule modulators of KLF15 signaling useful for treating various disorders such as, for example, kidney disease (e.g., chronic kidney disease), heart disease, obesity, or a neurodegenerative disorder (e.g., amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD)). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244762 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/573 (20130101) Acyclic or Carbocyclic Compounds C07C 321/20 (20130101) Heterocyclic Compounds C07D 213/74 (20130101) C07D 213/85 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210347804 | Ziegler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Ray Ziegler (State College, Pennsylvania); Joshua David Lambert (State College, Pennsylvania); Rachel Marie Shegog (State College, Pennsylvania); Emmanouil Chatzakis (State College, Pennsylvania); Deepti Dabas (Portage, Michigan) |
| ABSTRACT | The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange or yellow. The invention also provides compositions and methods for coloring edible materials to a desired color such as red, orange or yellow. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/301711 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 5/42 (20160801) A23L 5/47 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/26 (20130101) Original (OR) Class Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 61/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210349013 | YALIN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azer P. YALIN (Fort Collins, Colorado) |
| ABSTRACT | Systems and methods are disclosed to determine the concentration of a species within a sample. An example method may include collecting optical loss data over a range of frequencies from the sample using a spectroscopy system; placing the optical loss data into a plurality of bins, each bin having a defined frequency width; determining an average optical loss data value for the optical loss values within each bin that have an optical loss value less than a threshold value; removing the optical loss data within each bin having a value outside a tolerance range bounding the average optical loss data value for the respective bin; fitting a spectral curve to the remaining optical loss data; and determining the concentration of the species within the sample based on the spectral curve. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/381083 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/42 (20130101) G01J 2003/2869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/39 (20130101) G01N 21/3504 (20130101) Original (OR) Class G01N 2201/1248 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Treasury (TREASURY)
| US 20210347194 | Rich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WAVEFRONT TECHNOLOGY, INC. (Paramount, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Chapman Rich (Rancho Palos Verdes, California); Joel Mikael Petersen (Valley Village, California); Roger Winston Phillips (Santa Rosa, California); John Michael Tamkin (Pasadena, California) |
| ABSTRACT | A security device includes an array of lenses and a plurality of first and second segments disposed under the array of lenses. At a first viewing angle, the array of lenses presents a first image for viewing without presenting the second image for viewing, and at a second viewing angle different from the first viewing angle, the array of lenses presents for viewing the second image without presenting the first image for viewing. At least one first or second segment can include one or more microstructures or one or more nanostructures configured to produce one or more colors for the first or second image. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/104579 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/08 (20130101) B32B 3/30 (20130101) B32B 7/06 (20130101) B32B 27/08 (20130101) B32B 27/32 (20130101) B32B 27/36 (20130101) B32B 27/285 (20130101) B32B 27/302 (20130101) B32B 27/304 (20130101) B32B 27/365 (20130101) B32B 2307/408 (20130101) B32B 2307/4023 (20130101) Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/21 (20141001) B42D 25/324 (20141001) B42D 25/328 (20141001) B42D 25/351 (20141001) Original (OR) Class B42D 25/373 (20141001) B42D 25/378 (20141001) Special Designs or Pictures B44F 1/045 (20130101) Optical Elements, Systems, or Apparatus G02B 3/0056 (20130101) G02B 27/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20210351043 | Nah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jae-Woong Nah (Closter, New Jersey); Evan Colgan (Montvale, New Jersey); Robert P. Kuder, II (Hopewell Junction, New York); James L. Speidell (Poughquag, New York); Bucknell C. Webb (Ossining, New York) |
| ABSTRACT | A method and apparatus for bonding a processor wafer with a microchannel wafer/glass manifold to form a bonded wafer structure are provided. A glass fixture is also provided for protecting C4 solder bumps on chips disposed on the processor wafer. When the glass fixture is positioned on the processor wafer, posts extending from the glass fixture contact corresponding regions on the processor wafer devoid of C4 solder bumps, so that the glass fixture protects the C4 solder bumps during wafer bonding. The method involves positioning the processor wafer/glass fixture and the microchannel wafer/glass manifold in a metal fixture having one or more alignment structures adapted to engage corresponding alignment elements formed in the processor wafer, glass fixture and/or glass manifold. The metal fixture secures the wafer components in place and, after melting solder pellets disposed between the processor wafer/glass fixture and microchannel wafer/glass manifold, a bonded wafer structure is formed. |
| FILED | Friday, May 08, 2020 |
| APPL NO | 16/869744 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/4882 (20130101) Original (OR) Class H01L 21/67092 (20130101) H01L 23/473 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210347654 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aegis Technology Inc. (Santa Ana, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qi Chen (Santa Ana, California); Zhigang Lin (Santa Ana, California) |
| ABSTRACT | Producing CoxFe100-x, where x is an integer from 20 to 95, nanoparticles by: (a) providing a first aqueous hydroxide solution; (b) preparing a second aqueous solution containing iron ions and cobalt ions; and (c) depositing measured volumes of the second aqueous solution into the first aqueous solution whereby coprecipitation yields CoFe alloy nanoparticles, wherein step (c) occurs in an essentially oxygen-free environment. The nanoparticles are annealed at ambient temperatures to yield soft nanoparticles with targeted particle size, saturation magnetization and coercivity. The chemical composition, crystal structure and homogeneity are controlled at the atomic level. The CoFe magnetic nanoparticles have Ms of 200-235 emu/g, (Hc) coercivity of 18 to 36 Oe and size range of 5-40 nm. The high magnetic moment CoFe nanoparticles can be employed in drug delivery, superior contrast agents for highly sensitive magnetic resonance imaging, magnetic immunoassay, magnetic labeling, waste water treatment, and magnetic separation. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336310 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 49/0009 (20130101) C01G 51/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 20210346661 | JOHNSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Research Triangle Institute (Research Triangle Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leah Marie JOHNSON (Durham, North Carolina); Ariane VAN DER STRATEN (Kensington, California); Ginger Denison ROTHROCK (Zionsville, Indiana); Linying Alice LI (Durham, North Carolina); Ellen LUECKE (Research Triangle Park, North Carolina); Natalie GIROUARD (Research Triangle Park, North Carolina); Zach Richard DEMKOVICH (Durham, North Carolina); Sai Archana KROVI (Morrisville, North Carolina) |
| ABSTRACT | A reservoir device comprising an active agent formulation contained within a reservoir is described. The reservoir is defined by a biodegradable, permeable polymer membrane having a thickness of at least 45 μm. The membrane allows for diffusion of an active agent of the formulation there through when positioned subcutaneously in a body of a subject. |
| FILED | Wednesday, October 16, 2019 |
| APPL NO | 17/284989 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 2300/43 (20130101) A61L 2300/434 (20130101) A61L 2300/802 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 31/002 (20130101) Original (OR) Class A61M 2205/02 (20130101) A61M 2205/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20210348680 | Hundley, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Lyell Hundley, III (Fairfax, Virginia); Terry Martin Gingell (Spotsylvania, Virginia) |
| ABSTRACT | Installation devices, systems, methods of use, and methods of manufacture are described. An installation device that facilitates installing a toothed belt on a sprocket within a housing. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308387 |
| CURRENT CPC | Gearing F16H 57/00 (20130101) Original (OR) Class F16H 2057/0062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20210346963 | HOLCOMB et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GRID LOGIC INCORPORATED (Lapeer, Michigan) |
| ASSIGNEE(S) | GRID LOGIC INCORPORATED (Lapeer, Michigan) |
| INVENTOR(S) | Matthew J. HOLCOMB (Metamora, Michigan); Ira James HOLCOMB, JR. (Shelby Township, Michigan) |
| ABSTRACT | The invention relates to a manufacturing system including a holder suitable to hold first particles of a first powder in proximity to one another, and a connection scheme which, when employed, connects the first particles to one another to form a part. |
| FILED | Friday, May 07, 2021 |
| APPL NO | 17/315093 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/12 (20210101) B22F 12/30 (20210101) B22F 12/52 (20210101) B22F 12/53 (20210101) Original (OR) Class B22F 12/222 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, November 11, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page