FedInvent™ Patent Applications
Application Details for Thursday, December 02, 2021
This page was updated on Saturday, December 04, 2021 at 08:28 AM GMT
Department of Health and Human Services (HHS)
| US 20210369104 | Bleicher et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isaac Bleicher (Durham, North Carolina); Moseph Jackson-Atogi (Durham, North Carolina); Christian B. Viehland (Durham, North Carolina); Cynthia Toth (Durham, North Carolina); Joseph Izatt (Durham, North Carolina) |
| ABSTRACT | Systems and methods for providing surface contrast to display images for microsurgical applications are disclosed. According to an aspect, an imaging system includes an OCT apparatus configured to capture OCT data of an eye. The OCT image data can include depth-resolved images of reflected light intensity over a period of time. The imaging system also includes a controller configured to determine movement of the eye relative to the OCT imaging field-of-view. The controller may also determine a location within the imaged portion of the eye which tracks with the eye movement. Further, the controller may apply a color gradient to render OCT images of the eye based on a position relative to the determined location of the eye tracking location. The controller may also control a display to display the OCT images with the applied color gradient. |
| FILED | Friday, November 30, 2018 |
| APPL NO | 16/759721 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0041 (20130101) A61B 3/102 (20130101) Original (OR) Class A61B 3/1173 (20130101) A61B 3/1225 (20130101) Image Data Processing or Generation, in General G06T 1/20 (20130101) G06T 7/0012 (20130101) G06T 7/20 (20130101) G06T 7/70 (20170101) G06T 11/001 (20130101) G06T 11/008 (20130101) G06T 2207/10101 (20130101) G06T 2207/30041 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 30/40 (20180101) G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369146 | DATTA et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Sandeep Robert DATTA (Newton, Massachusetts); Alexander Bame WILTSCHKO (Somerville, Massachusetts); Matthew J. JOHNSON (Hillsborough, California) |
| ABSTRACT | Systems and methods are disclosed to objectively identify sub-second behavioral modules in the three-dimensional (3D) video data that represents the motion of a subject. Defining behavioral modules based upon structure in the 3D video data itself—rather than using a priori definitions for what should constitute a measurable unit of action—identifies a previously-unexplored sub-second regularity that defines a timescale upon which behavior is organized, yields important information about the components and structure of behavior, offers insight into the nature of behavioral change in the subject, and enables objective discovery of subtle alterations in patterned action. The systems and methods of the invention can be applied to drug or gene therapy classification, drug or gene therapy screening, disease study including early detection of the onset of a disease, toxicology research, side-effect study, learning and memory process study, anxiety study, and analysis in consumer behavior. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/241863 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/00 (20130101) A61B 5/1123 (20130101) A61B 5/1128 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 2503/40 (20130101) A61B 2503/42 (20130101) A61B 2576/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/209 (20130101) G06K 9/00335 (20130101) G06K 9/6247 (20130101) G06K 9/6297 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369160 | ANDESHMAND et al. |
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| FUNDED BY |
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| APPLICANT(S) | Talis Biomedical Corporation (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sayeed ANDESHMAND (Dublin, California); Thomas H. CAULEY, III (Redwood City, California); John DIXON (Moss Beach, California); David GLADE (San Ramon, California); Hédia MAAMAR (El Dorado Hills, California); Michael John McADAMS (Los Gatos, California); Dzam-Si Jesse NG (Fremont, California); David Alexander ROLFE (San Francisco, California) |
| ABSTRACT | Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230804 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/150755 (20130101) A61B 5/150961 (20130101) Original (OR) Class Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369180 | Chugh |
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| FUNDED BY |
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| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| INVENTOR(S) | Sumeet S. Chugh (Santa Monica, California) |
| ABSTRACT | A system and a method for identifying a patient with a threshold number of distinct ECG abnormalities. The system and the method include an ECG monitoring device; a server; a database; a network; a memory containing machine readable medium comprising a machine executable code having stored thereon instructions for identifying patients with a threshold number of distinct ECG abnormalities; and a processor coupled to the memory, the processor configured to execute the machine executable code to cause the processor to: receive an ECG data output from the ECG monitoring device; process the ECG data output to identify abnormalities in the ECG data; and analyze the abnormalities in the ECG data in order to output an indication of whether the patient has depressed LVEF, wherein the ECG monitoring device, the server, the database, the memory, and the processor are coupled to the network via communication links. |
| FILED | Tuesday, April 17, 2018 |
| APPL NO | 16/605726 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/36 (20210101) A61B 5/271 (20210101) A61B 5/353 (20210101) A61B 5/366 (20210101) Original (OR) Class A61B 5/02028 (20130101) A61B 5/02438 (20130101) A61B 5/7264 (20130101) A61B 2560/02 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369187 | Raju et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (Tuscaloosa, Alabama) |
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| INVENTOR(S) | Viprav Bhaskar Raju (Tuscaloosa, Alabama); Edward Sazonov (Northport, Alabama) |
| ABSTRACT | In an embodiment, a non-contact chewing sensor is provided. The chewing sensor includes an optical proximity sensor specifically designed to monitor chewing. An IR emitter/receiver pair of the chewing sensor may be positioned over a muscle of a user that is involved in the chewing process such as the temporalis muscle. The IR emitter of the sensor emits IR light onto the surface of the skin covering the muscle where it is reflected. When the user chews, the amount of light that is received by the IR receiver changes due to the activation of the muscle. The amount of light received can be used as a signal to determine when the user is chewing and likely eating. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/211097 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0077 (20130101) A61B 5/1113 (20130101) A61B 5/4542 (20130101) Original (OR) Class A61B 5/6803 (20130101) A61B 2562/0219 (20130101) A61B 2562/0238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369253 | Stoianovici et al. |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
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| INVENTOR(S) | Dan Stoianovici (Reisterstown, Maryland); Doru Petrisor (Lutherville, Maryland); Changhan Jun (College Park, Maryland); Sunghwan Lim (Baltimore, Maryland) |
| ABSTRACT | An embodiment in accordance with the present invention provides a remote center of motion robot. The RCM here is a parallelogram bar type RCM mechanism with a novel joint arrangement. The novel joint arrangement facilitates the mounting of the medical instrument and offers improved clearance relative to the patient. Moreover, the robot was built to guide a bone biopsy cannula, needle, or drill. Even though exact interventional values are unknown, it is expected that the forces exerted laterally on the needle-guide are higher than those encountered for slender needle insertion into soft tissue. For this, the RCM has been built with novel structure to enhance stiffness. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404741 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/025 (20130101) Original (OR) Class A61B 34/30 (20160201) A61B 90/03 (20160201) A61B 90/11 (20160201) A61B 90/50 (20160201) Manipulators; Chambers Provided With Manipulation Devices B25J 9/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369256 | Markowitz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford Markowitz (Cleveland, Ohio); Amitabh Chak (Cleveland, Ohio); Joseph Willis (Cleveland, Ohio); Lishan Aklog (Purchase, New York); Richard Yazbeck (Norwell, Massachusetts); Michael Boutillette (San Francisco, California); Brian deGuzman (Paradise Valley, Arizona); David Wurtman (New York, New York) |
| ABSTRACT | A method for collecting a cell sample, including eosinophil white blood cells in a patient is provided. The method includes advancing to a location in an esophagus associated with eosinophilic esophagitis (EoE), a device provided with a collection portion having a first axial end portion and an inflatable second axial end portion. Thereafter, axially moving the second axial end portion, relative to the first axial end portion, from a collapsed position within the first axial end portion into an expanded position out from the first axial end portion. Once the second axial end portion is in the expanded position, allowing it to engage the location associated with EoE to collect a sample of cells. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331375 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/04 (20130101) Original (OR) Class A61B 2010/0216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369437 | Tranquillo et al. |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Tranquillo (Arden Hills, Minnesota); Zeeshan Syedain (Minneapolis, Minnesota); Lee Meier (Minneapolis, Minnesota) |
| ABSTRACT | This disclosure describes decellularized, biologically-engineered tubular grafts and methods of making and using such decellularized, biologically-engineered tubular grafts. |
| FILED | Thursday, December 31, 2020 |
| APPL NO | 17/139575 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/04 (20130101) A61F 2/06 (20130101) Original (OR) Class A61F 2/062 (20130101) A61F 2/2412 (20130101) A61F 2/2415 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/36 (20130101) A61L 27/507 (20130101) A61L 27/3604 (20130101) A61L 27/3633 (20130101) A61L 27/3695 (20130101) A61L 2430/40 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 23/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369633 | Appel et al. |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
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| INVENTOR(S) | Eric A. Appel (Cambridge, Massachusetts); Mark W. Tibbitt (Cambridge, Massachusetts); Robert S. Langer (Newton, Massachusetts) |
| ABSTRACT | Network materials which exhibit both shear thinning and self-healing properties are disclosed. The networks contain particles and gel-forming compounds. The networks are useful for a variety of biomedical uses, including drug delivery. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/342368 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/5146 (20130101) A61K 9/5153 (20130101) A61K 9/5161 (20130101) Original (OR) Class A61K 47/30 (20130101) A61K 47/34 (20130101) A61K 47/36 (20130101) A61K 47/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369652 | Lishko et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Polina V. Lishko (Berkeley, California); William Skinner (Berkeley, California); Liliya Gabelev Khasin (Berkeley, California); Emiliano Tabarsi (Berkeley, California); Ambre M. Bertholet (San Francisco, California); Yuriy Kirichok (San Francisco, California) |
| ABSTRACT | Nonhormonal unisex contraceptive products, compositions, formulations and methods of use comprise an effective amount of a targeted mild mitochondria uncoupler. |
| FILED | Sunday, August 01, 2021 |
| APPL NO | 17/391026 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/166 (20130101) A61K 31/167 (20130101) Original (OR) Class A61K 31/4985 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/16 (20180101) A61P 15/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369670 | Sah |
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| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | Rajan Sah (Iowa City, Iowa) |
| ABSTRACT | The invention provides the use of SWELL1 inhibitors and modulators for therapeutic use, e.g., to treat obesity and type 2 diabetes. |
| FILED | Friday, August 04, 2017 |
| APPL NO | 16/322709 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) Original (OR) Class A61K 31/138 (20130101) A61K 31/192 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369677 | DeCaen |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul G. DeCaen (Wilmette, Illinois) |
| ABSTRACT | Disclosed are methods of treating diseases or disorders associated with the activity of polycyctic kidney disease 2 (PKD2). The disclosed methods may be utilized to treat diseases or disorders associated with polycystic kidney disease, for example autosomal dominant polycystic kidney disease (ADPKD). Also disclosed are activators of PKD2. The disclosed compounds may also be used in pharmaceutical compositions and methods for treatment of polycystic kidney disease or disorders associated with PKD2 activity. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/303397 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/145 (20130101) A61K 31/4174 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369679 | Riggins et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Gregory Riggins (White Hall, Maryland); Renyuan Bai (Joppa, Maryland); Verena Staedtke (Baltimore, Maryland); Avadhut D. Joshi (Baltimore, Maryland); Tara Williamson (Baltimore, Maryland) |
| ABSTRACT | Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy. Three polymorphs of mebendazole exist, but the relative polymorph content for existing drugs varies, and the therapeutic anti-cancer relevance of the different polymorphs was unknown. As an oral drug mebendazole polymorph C is a superior form, and it reaches the brain and brain tumors in effective concentrations. Efficacy is further improved by combining mebendazole with a P-glycoprotein inhibitor. Mebendazole may also be used for therapy of other cancers, as well as a chemo-preventative agent. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/402131 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/10 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 9/50 (20130101) A61K 9/0056 (20130101) A61K 9/1605 (20130101) A61K 31/192 (20130101) A61K 31/473 (20130101) A61K 31/4184 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369683 | Hall et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); The UAB Research Foundation (Birmingham, Alabama); The United States of America, as Represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Hall (Damestown, Maryland); Daniel J. Urban (Poolesville, Maryland); John Knight (Birmingham, Alabama); Ross Holmes (Birmingham, Alabama); Kyle David Wood (Birmingham, Alabama); Alex Waterson (Nashville, Tennessee); Victor M. Darley-Usmar (Birmingham, Alabama); Leonard M. Neckers (Bethesda, Maryland) |
| ABSTRACT | The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amound of compound of the formula and pharmaceutically acceptable salts, solvates, and hydrates thereof to the patient. The variables, e.g. ring A, n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful inhibiting the conversion of glyoxylate to oxalate. When administered to a patient having a disease or disorder associated with elevated oxalate levels, such as PH type 1, type 2, or type 3 or idiopathic hyperoxaluria the compounds prevent or substantially reduce the amount and buildup of oxalate the patient's kidneys, bladder, urinary tract and other parts of the patient's body. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/322260 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/4439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369704 | Largent-Milnes et al. |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tally M. Largent-Milnes (Tucson, Arizona); Erika Liktor-Busa (Tucson, Arizona); Todd W. Vanderah (Tucson, Arizona); Nephi Stella (Seattle, Washington) |
| ABSTRACT | This invention relates generally to compositions and methods for preventing, reducing the occurrence of or treating a headache in a subject in need thereof. In particular, the present invention relates to methods for enhancing 2-arachydonyl glycerol (2AG) tone and reducing prostaglandin activity in a subject for purposes of preventing, reducing the occurrence of or treating a headache (e.g., a migraine headache) in a subject. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331025 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369713 | Augelli-Szafran et al. |
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| FUNDED BY |
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| APPLICANT(S) | SOUTHERN RESEARCH INSTITUTE (Birmingham, Alabama); THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | SOUTHERN RESEARCH INSTITUTE (Birmingham, Alabama); THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| INVENTOR(S) | Corinne E. Augelli-Szafran (Homewood, Alabama); Omar Moukha-Chafiq (Birmingham, Alabama); Mark J. Suto (Homewood, Alabama); Anath Shalev (Mountain Brook, Alabama); Lance Thielen (Lenexa, Kansas); Junqin Chen (Vestavia Hills, Alabama); Gu Jing (Vestavia Hills, Alabama) |
| ABSTRACT | In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 17/374100 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Original (OR) Class A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 3/06 (20180101) A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369714 | Bikle et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel D. Bikle (San Francisco, California); Tejal Ashwin Desai (San Francisco, California); Long V. Le (San Franciso, California); Yongmei Wang (San Francisco, California) |
| ABSTRACT | The present disclosure provides methods for treating or preventing osteoarthritis in a subject in need thereof. In certain aspects, the methods include administering an inhibitor of insulin growth factor-1 (IGF-1) signaling to a joint of the subject in an amount effective to treat or prevent osteoarthritis. In certain aspects, the osteoarthritis treated or prevented by the methods disclosed herein may to be post-traumatic osteoarthritis. |
| FILED | Thursday, September 26, 2019 |
| APPL NO | 17/277978 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0092 (20130101) A61K 31/519 (20130101) Original (OR) Class Peptides C07K 16/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369720 | Mouradian et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey); The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Mary M. Mouradian (Princeton, New Jersey); Jeffry B. Stock (Princeton, New Jersey) |
| ABSTRACT | A neuroprotective compositions containing caffeine or a caffeine analogue and a long chain fatty acyl tryptamide with an aliphatic chain having 16 to 22 carbons linked to a tryptamine, wherein the composition contains from at least 1.5 mg to 600 mg of caffeine per serving or unit dosage of the composition; from at least 0.5 mg to 300 mg of the long chain fatty acyl tryptamide per serving or unit dosage of the composition; and the ratio of long chain fatty acyl tryptamide to caffeine is from 1:1200 to 200:1. Methods are also disclosed for treating or preventing cognitive and movement deficits of a disease, condition or disorder or neurological deterioration that use the disclosed neuroprotective compositions. |
| FILED | Friday, November 01, 2019 |
| APPL NO | 17/290870 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) Original (OR) Class A61K 31/4045 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369742 | Chauhan et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | Anil Chauhan (Iowa City, Iowa); Manasa K. Nayak (Iowa City, Iowa) |
| ABSTRACT | The present invention provides in certain embodiments methods of inhibiting platelet function or thrombosis, inhibiting pyruvate kinase M2 (PKM2) dimerization, and/or treating a disease associated with thrombosis by administering a composition comprising a dimeric pyruvate kinase M2 (PKM2) inhibitor in a patient in need thereof. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331366 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/63 (20130101) Original (OR) Class A61K 31/5025 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369744 | Isacoff et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Max-Planck-Gesellschalt Zur Foerderung der Wissenschaften e.V. (Munchen, Germany); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ehud Y. Isacoff (Berkeley, California); Johannes Broichhagen (Munchen, Germany); Joshua T. Levitz (Ithaca, New York) |
| ABSTRACT | The present disclosure provides a conjugate comprising an affinity agent, a branched linker, and two or more photoisomerizable regulators. The present disclosure provides compositions comprising the conjugate, as well as devices comprising the compositions. The present disclosure provides methods for enhancing visual function, the methods comprising administering the conjugate to an individual in need thereof. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332865 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 9/0008 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/52 (20130101) A61K 31/655 (20130101) Original (OR) Class A61K 35/76 (20130101) A61K 38/16 (20130101) A61K 47/40 (20130101) A61K 47/60 (20170801) A61K 47/65 (20170801) A61K 47/6849 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369747 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lingyin LI (Stanford, California); Mark SMITH (San Francisco, California); Kelsey Erin SHAW (Atlanta, Georgia); Jacqueline Ann CAROZZA (Stanford, California); Volker BOEHNERT (Palo Alto, California) |
| ABSTRACT | Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with a ENPP1 inhibitor to inhibit cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor is cell impermeable. Also provided are compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of a ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject either before or after administering an ENPP1 inhibitor. The radiation therapy can be administered at a dosage and/or frequency effective to reduce radiation damage to the subject. In certain cases, the method is performed in combination with a chemotherapeutic agent, or a checkpoint inhibitor, or both. |
| FILED | Friday, September 07, 2018 |
| APPL NO | 16/645300 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369781 | Brentjens et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Renier J. Brentjens (Short Hills, New Jersey); Hollie J. Jackson (New York, New York) |
| ABSTRACT | The present invention provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to immunoresponsive cells bearing antigen receptors, which can be chimeric antigen receptors (CARs), which express introduced ligands for immunomodulatory molecules. In particular embodiments, engineered immunoresponsive cells are antigen-directed and resist immunosuppression and/or have enhances immune-activating properties. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400689 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 35/545 (20130101) Peptides C07K 14/7051 (20130101) C07K 16/2803 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369783 | Orwig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Kyle E. Orwig (Wexford, Pennsylvania); Hanna Valli-Pulaski (Coraopolis, Pennsylvania) |
| ABSTRACT | Ultrasound-guided rete testis injection/aspiration devices and methods are described. Some methods include inserting a needle into the rete testis space of a patient and injecting a therapeutic medium through the needle into the rete testis space and seminiferous tubules of the testis. The therapeutic medium can help to treat infertility. In some examples, the method can include monitoring intra-testicular pressure of the patient. In some examples, the therapeutic medium can include stem cells. In some examples, the therapeutic medium can include gene therapy vectors. In some examples, the method can include flushing the rete testis space and seminiferous tubules with a saline solution through the needle. Exemplary devices can include a dual lumen needle, a collection tube, a dual function pump, and flexible tubing. The dual function pump can include a dual syringe pump and a vacuum pump. |
| FILED | Friday, December 06, 2019 |
| APPL NO | 17/272713 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 48/00 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/427 (20130101) A61M 5/1422 (20130101) A61M 5/1582 (20130101) A61M 2205/3344 (20130101) A61M 2210/161 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369795 | Pamer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Eric Pamer (Montclair, New Jersey); Jedd D. Wolchok (New York, New York); Krista Dubin (New York, New York) |
| ABSTRACT | The present invention relates to methods and compositions for identifying subjects treated with or considered for treatment with checkpoint blockade therapeutic agents that are at higher or lower risk for developing checkpoint therapy associated colitis, by analyzing the intestinal microbiome of those subjects. It is based, at least in part, on the discovery that the abundance of certain intestinal microbiota of the phyla Bacteroidetes, including the bacteria in the families Bacteroidaceae, Rikenellaceae, and Barnesisllaceae, and/or an increase or decrease in microbial genetic pathways involved in polyamine transport and/or B vitamin biosynthesis (e.g., (riboflavin (B2), pantothenate (B5) and thiamine (B1)) are associated with the likelihood of developing checkpoint therapy associated colitis. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/350952 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 5/00 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0031 (20130101) A61K 9/0043 (20130101) A61K 9/0053 (20130101) A61K 35/742 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2035/115 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) G01N 2800/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369808 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gong CHEN (State College, Pennsylvania); Gang-Yi WU (State College, Pennsylvania); Lei ZHANG (State College, Pennsylvania); Jiu-Chao YIN (State College, Pennsylvania); Hana YEH (State College, Pennsylvania); Ning-Xin MA (State College, Pennsylvania); Grace LEE (State College, Pennsylvania) |
| ABSTRACT | Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG; purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397927 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/4439 (20130101) A61K 38/05 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 2501/15 (20130101) C12N 2501/155 (20130101) C12N 2501/727 (20130101) C12N 2501/998 (20130101) C12N 2501/999 (20130101) C12N 2506/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369810 | Totary-Jain |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | Hana Totary-Jain (Wesley Chapel, Florida) |
| ABSTRACT | Described herein are cell-selective mRNA constructs that can contain a RNA of interest and one or more miRNA targets. The cell-selective mRNA constructs described herein can be used to express an RNA of interest to a cell in a cell-selective manner. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400984 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 31/7115 (20130101) A61K 38/1709 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2310/113 (20130101) C12N 2710/10343 (20130101) Enzymes C12Y 207/07048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369820 | ZHANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Health Research, Inc. (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuesheng ZHANG (Orchard Park, New York); Lu YANG (Buffalo, New York); Yun LI (Orchard Park, New York) |
| ABSTRACT | Provided are compositions and methods for prophylaxis and/or therapy of ErbB2-positive cancer. The compositions include pharmaceutical preparations that contain isolated or recombinant or modified peptidase D (PEPD) proteins. The methods include prophylaxis and/or therapy of ErbB2-positive cancer by administering a PEPD to an individual who has or is at risk for developing ErbB2-positive cancer. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/384894 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/4813 (20130101) Original (OR) Class A61K 39/00 (20130101) A61K 45/06 (20130101) Peptides C07K 2319/21 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) Enzymes C12Y 304/13009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369823 | Tomlinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MUSC Foundation For Research Development (Charleston, South Carolina); United States Government as Represented by the Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Tomlinson (Charleston, South Carolina); DeAnna Adkins (Charleston, South Carolina); Ali Alawieh (Charleston, South Carolina) |
| ABSTRACT | The present invention describes compositions and method for improving outcomes after injury to the central nervous system wherein complement signaling is activated. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a therapeutic agent comprising a targeted inhibitor molecule comprising a targeting portion and an inhibitor portion, wherein the molecule inhibits complement, and wherein therapeutic agent is administered in combination with rehabilitation therapy or thrombolytic agent. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/320410 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/49 (20130101) A61K 38/57 (20130101) Original (OR) Class A61K 38/1709 (20130101) A61K 38/1725 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Peptides C07K 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369828 | Steinmetz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (San Diego, California); Sourabh Shulka (Cleveland, Ohio) |
| ABSTRACT | A vaccine composition includes an icosahedral-shaped plant virus or virus-like particle linked to a plurality of NY-ESO-1 antigens. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333797 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001188 (20180801) Original (OR) Class A61K 2039/5258 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369833 | Price et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Silver Spring, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Silver Spring, Maryland) |
| INVENTOR(S) | Gregory A. Price (Silver Spring, Maryland); Che-Hung Robert Lee (Silver Spring, Maryland); Margaret Bash (Silver Spring, Maryland) |
| ABSTRACT | Immunogenic compositions that include a bacterial capsular polysaccharide conjugated to a carrier protein are described. In some embodiments, the bacterial capsular polysaccharide is a Neisseria meningitidis capsular polysaccharide. The carrier protein includes an N. meningitidis factor H binding protein (fHbp) linked to cholera toxin subunit B (CTB). Administration of the immunogenic compositions elicits an immune response that includes production of meningococcal polysaccharide-specific and fHbP-specific antibodies. Use of the immunogenic compositions as meningococcal vaccines is also described. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399944 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/095 (20130101) Original (OR) Class A61K 39/107 (20130101) A61K 2039/6037 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369838 | HEROLD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Betsy C. HEROLD (Rowayton, Connecticut); Clare Burn Aschner (Bronx, New York) |
| ABSTRACT | Methods of vaccinating, immunizing and/or treating a subject against a herpes simplex virus infection or a disease caused by a herpes simplex virus infection comprise administering to the subject an effective amount of a HSV-2 single-cycle virus and an effective amount of a recombinant HSV-2 glycoprotein D, wherein the HSV-2 single-cycle virus comprises HSV-2 having a deletion of glycoprotein D-encoding gene in the genome and the HSV-2 is phenotypically complemented with an HSV-1 glycoprotein D on a lipid bilayer of the HSV-2. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335548 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/245 (20130101) Original (OR) Class A61K 2039/54 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369849 | EBETINO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Frank Hallock EBETINO (Venice, Florida); Shuting SUN (Temple City, California); Charles E. MCKENNA (Pacific Palisades, California); Keivan SADRERAFI (Pasadena, California); Philip CHERIAN (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank Hallock EBETINO (Venice, Florida); Shuting SUN (Temple City, California); Charles E. MCKENNA (Pacific Palisades, California); Keivan SADRERAFI (Pasadena, California); Philip CHERIAN (Pasadena, California) |
| ABSTRACT | Described herein are bisphosphonate oxazolidinone compounds, and conjugates and pharmaceutical formulations thereof, that can include a bisphosphonate and an oxazolidinone (or an oxazolidinone antimicrobial or antibiotic agent, substituent or derivative thereof), where the oxazolidinone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate oxazolidinone compounds, conjugates and pharmaceutical formulations thereof. Also provided herein are methods of use of the compounds, conjugates and formulations for treating a bone disease or for use in preparing a formulation for the treatment a bone disease. |
| FILED | Tuesday, June 25, 2019 |
| APPL NO | 17/255446 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 31/422 (20130101) A61K 31/496 (20130101) A61K 31/541 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) A61K 47/542 (20170801) A61K 47/548 (20170801) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 27/3608 (20130101) A61L 2300/216 (20130101) A61L 2300/404 (20130101) A61L 2430/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369860 | ANCHORDOQUY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORAD (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas ANCHORDOQUY (Lakewood, Colorado); Michael GRANER (Aurora, Colorado); Jamie BETKER (Denver, Colorado); Brittany ANGLE (Golden, Colorado) |
| ABSTRACT | Drug delivery systems comprising binding partners conjugated to a nanoparticle encapsulating a therapeutic agent formulated for oral administration, and methods of delivering therapeutic agents across the gastrointestinal epithelium. |
| FILED | Thursday, October 24, 2019 |
| APPL NO | 17/288104 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 31/4745 (20130101) A61K 47/643 (20170801) A61K 47/6849 (20170801) A61K 47/6931 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369861 | Xu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Peisheng Xu (Chapin, South Carolina) |
| ABSTRACT | A carrier-free nanoparticle based on the self-assembly of curcumin-erlotinib conjugate (EPC) that exhibits stronger cell killing, better anti-migration effects, and anti-invasion effects for pancreatic cancer cells than the combination of free curcumin and erlotinib. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213750 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) A61K 9/5146 (20130101) A61K 9/5192 (20130101) A61K 47/54 (20170801) A61K 47/60 (20170801) A61K 47/6935 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369871 | McIvor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); REGENXBIO Inc. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | R. Scott McIvor (St. Louis Park, Minnesota); Lalitha R. Belur (St. Paul, Minnesota); Karen Kozarsky (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | A method to prevent, inhibit or treat one or more symptoms associated with disease of the central nervous system by intranasally, intrathecally, intracerebrcvascularly or intravenously administering a rAAV encoding a gene product associated with the disease, e.g., a mammal in which the gene product is absent or present at a reduced level relative to a mammal without the disease, in an amount effective, e.g., to provide for cross-correction. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344308 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 31/675 (20130101) A61K 38/47 (20130101) A61K 45/06 (20130101) A61K 48/0075 (20130101) Original (OR) Class A61K 48/0083 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) Enzymes C12Y 302/01076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369910 | LUCAS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandra LUCAS (Tempe, Arizona); Liqiang ZHANG (Chandler, Arizona); Jordan YARON (Scottsdale, Arizona); Grant McFADDEN (Tempe, Arizona) |
| ABSTRACT | Disclosed herein are topical compositions for treating wounds. The topically compositions include a Serp-1 polypeptide or a nucleic acid encoding a Serp-1 polypeptide. Also disclosed are methods of treating a wound in subject. The methods include administering a topical formulation that includes a Serp-1 polypeptide or a nucleic acid encoding a Serp-1 polypeptide to the wound. |
| FILED | Friday, May 17, 2019 |
| APPL NO | 17/056401 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/36 (20130101) A61K 47/42 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 26/008 (20130101) A61L 26/0066 (20130101) Original (OR) Class Peptides C07K 14/8121 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370037 | Miao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Seattle Children's Hospital D/B/A Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | Seattle Children's Hospital D/B/A Seattle Children's Research Institute (Seattle, Washington) |
| INVENTOR(S) | Carol Hsing Miao (Seattle, Washington); Feng Zhang (Seattle, Washington) |
| ABSTRACT | Transcutaneous, ultrasound-mediated methods for administering compound(s) to subject tissue(s) are provided. Examples involve positioning an occluding device in a vessel such that the blockage is adjacent to target tissue; engaging the device to occlude outflow from a region adjacent to the tissue; administering compound(s) to the vessel such that it is substantially retained adjacent to the target tissue; determining the location of the compound and/or a detectable adjunct compound optionally administered with the compound, using diagnostic ultrasound, radiography, or fluorography; administering therapeutic ultrasound energy transcutaneously to mediate delivery of the compound across the vessel wall and into adjacent target tissue. |
| FILED | Friday, April 26, 2019 |
| APPL NO | 17/051141 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0075 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0092 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2007/0039 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370059 | Tai |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changfeng Tai (Wexford, Pennsylvania) |
| ABSTRACT | Provided herein are devices, systems, and methods for treating urological and gastrointestinal disorders, including bedwetting, through stimulation of the dorsal or plantar surface of the foot, including the superficial peroneal nerve and branches thereof, such as the dorsal intermediate and medial cutaneous nerves, or the medial and/or and lateral plantar nerves. The device facilitates placement of electrodes on the foot. Also provided herein is a system including the device, a pulse generator, and a controller, and methods of manufacturing and using the same. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318110 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) A61K 31/381 (20130101) A61K 31/428 (20130101) A61K 31/435 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/04 (20130101) A61N 1/18 (20130101) A61N 1/24 (20130101) A61N 1/32 (20130101) A61N 1/372 (20130101) A61N 1/0456 (20130101) A61N 1/0484 (20130101) A61N 1/0492 (20130101) A61N 1/3603 (20170801) A61N 1/36007 (20130101) Original (OR) Class A61N 1/36021 (20130101) A61N 1/36034 (20170801) A61N 1/37264 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370071 | Fridman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gene Yevgeny Fridman (Baltimore, Maryland) |
| ABSTRACT | Current state of the art neural prosthetics, such as cochlear implants, spinal cord stimulators, and deep brain stimulators use implantable pulse generators (IPGs) to excite neural activity. Inhibition of neural firing is typically indirect and requires excitation of neurons that then have inhibitory projections downstream. The present invention is directed to a safe direct current stimulator (SDCS) technology that is designed to convert electronic pulses delivered to electrodes embedded within an implantable device to ionic direct current (iDC) at the output of the device. iDC front the device can then control neural extracellular potential with the intent of being able to not only excite, but also inhibit and sensitize neurons, thereby greatly expanding the possible applications of neuromodulation therapies and neural interface mechanisms. The device of the present invention is designed to reduce power consumption by a factor of 12 and to improve its reliability by a factor of 8. |
| FILED | Monday, July 09, 2018 |
| APPL NO | 16/629168 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/20 (20130101) A61N 1/378 (20130101) A61N 1/36157 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370087 | Thyagarajan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krishnan Thyagarajan (Mountain View, California); George Daniel (Palo Alto, California); Bernard D. Casse (Saratoga, California) |
| ABSTRACT | An implantable magnetic neurostimulation probe includes at least one electrical conductor disposed on a substrate and arranged in at least one planar loop. At least one planar magnetic core comprising a magnetic material is disposed on the substrate and within the planar loop. A biocompatible coating is disposed over the substrate, electrically conductive trace, and magnetic core. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400578 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/37211 (20130101) A61N 2/02 (20130101) Original (OR) Class A61N 2/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370122 | Mohieldin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire); Mary Hitchcock Memorial Hospital, for itself and on behalf of Dartmouth Hitchcock Clinic (Lebanon, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suehayla Mohieldin (Bethesda, Maryland); Ryan J. Halter (Lyme, New Hampshire); John A. Batsis (Chapel Hill, North Carolina); Colin Minor (Southport, North Carolina); Curtis Lee Petersen (Portland, Oregon) |
| ABSTRACT | Devices and methods are disclosed for remote clinical monitoring performance of exercises using a smart resistance exercise device including a resistance band, a first handle connected to a first end of the resistance band and a second handle connected to a second end of the resistance band, a force sensing assembly operably coupled to the resistance band, and a local receiving device communicatively coupled to the force sensing assembly. The force sensing assembly of the device includes a housing, and a force sensor disposed in the housing and operatively connected to the resistance band to measure a force exerted on the resistance band. The force sensing assembly also includes a processing and communication module communicatively coupled to the force sensor to receive measurements of the force sensor and communicatively coupled to the local receiving device to transmit the measurements to the local receiving device. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335986 |
| CURRENT CPC | Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 21/00043 (20130101) Original (OR) Class A63B 2220/51 (20130101) A63B 2220/58 (20130101) A63B 2220/833 (20130101) A63B 2225/20 (20130101) A63B 2225/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370241 | Bhattacharyya et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dibakar Bhattacharyya (Lexington, Kentucky); Anthony Saad (Lexington, Kentucky); Rollie Mills (Lexington, Kentucky); Lindell Ormsbee (Lexington, Kentucky); M. Abdul Mottaleb (Lexington, Kentucky) |
| ABSTRACT | Purification devices and methods remove perfluorinated compounds (PFCs) from PFC-contaminated water using temperature swing adsorption and desorption. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 16/885369 |
| CURRENT CPC | Separation B01D 69/125 (20130101) B01D 69/147 (20130101) Original (OR) Class B01D 71/34 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/267 (20130101) B01J 20/321 (20130101) B01J 20/2805 (20130101) B01J 20/3483 (20130101) B01J 20/28047 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/285 (20130101) C02F 1/288 (20130101) C02F 2101/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370292 | DOUGLAS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Tech Intellectual Properties, Inc. (BLACKSBURG, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Temple DOUGLAS (Blacksburg, Virginia); Phillip Melvin GRAYBILL (Blacksburg, Virginia); Rafael DAVALOS (Blacksburg, Virginia) |
| ABSTRACT | Described herein are aspects of a microfluidic separation and assay system that can include a microfluidic contactless dielectrophoretic (cDEP) device, a microfluidic concentrator, and a microfluidic assay chamber. In some aspects, microfluidic separation and assay system can be included on a single microfluidic chip. Also described herein are methods of using the microfluidic separation and assay system described herein. |
| FILED | Tuesday, March 12, 2019 |
| APPL NO | 16/980362 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2300/069 (20130101) B01L 2300/0645 (20130101) B01L 2300/0829 (20130101) B01L 2300/0883 (20130101) B01L 2400/0424 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 5/005 (20130101) B03C 2201/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370319 | Hayes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Hayes (Gilbert, Arizona); Claire Crowther (Tempe, Arizona); Paul Jones (Mesa, Arizona) |
| ABSTRACT | The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400419 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) B01L 2400/086 (20130101) B01L 2400/0424 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 5/005 (20130101) B03C 5/026 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1056 (20130101) G01N 15/1484 (20130101) G01N 27/447 (20130101) G01N 27/44791 (20130101) G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371375 | HURLEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laurence HURLEY (Tucson, Arizona); Vijay GOKHALE (Tucson, Arizona); HyunJin KANG (Tucson, Arizona); Kui WU (Tucson, Arizona) |
| ABSTRACT | The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula: whereas, n, R1, R2, R3, RH and R12 are as defined herein. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200444 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/505 (20130101) A61K 31/4402 (20130101) A61K 31/4995 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 275/54 (20130101) Original (OR) Class Heterocyclic Compounds C07D 219/08 (20130101) C07D 239/34 (20130101) C07D 239/52 (20130101) C07D 241/18 (20130101) C07D 295/088 (20130101) C07D 401/12 (20130101) C07D 403/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371383 | JIAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HAWAII BIOTECH, INC. (Honolulu, Hawaii) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guan-Sheng JIAO (Aiea, Hawaii); Seong Jin KIM (Honolulu, Hawaii); Alan T. JOHNSON (Kaneohe, Hawaii) |
| ABSTRACT | Compounds of formula I are provided: wherein X is NH, or CH2, Y is a single bond, or —CHR5—, R1 is H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, R2 and R2′ are each independently H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, each R3 is independently H, halo, —CF3, C1-C4 alkyl, or C1-C4 alkoxy, C3 perhaloalkyl, each R4 is independently H, halo, or C1-C4 alkyl, R5 is C1-C4 alkoxy, r is integer from 0 to 3; and p is integer from 0 to 3. |
| FILED | Tuesday, March 12, 2019 |
| APPL NO | 16/979503 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/54 (20130101) C07D 213/61 (20130101) C07D 213/65 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371388 | Du et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baruch S. Blumberg Institute (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanming Du (Cheshire, Connecticut); Ju-Tao Guo (Lansdale, Pennsylvania); Nicky Hwang (Doylestown, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions of the invention comprise functionalized bicyclic carboxamide useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318680 |
| CURRENT CPC | Heterocyclic Compounds C07D 215/233 (20130101) C07D 241/04 (20130101) C07D 241/48 (20130101) C07D 241/52 (20130101) Original (OR) Class C07D 265/36 (20130101) C07D 279/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371439 | Schiffer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Celia A. Schiffer (Shrewsbery, Massachusetts); Akbar Ali (Westborough, Massachusetts); Nese Kurt-Yilmaz (Shrewsbury, Massachusetts); Linah N. Rusere (Hendersonville, North Carolina); Gordon J. Lockbaum (Worcester, Massachusetts); Mina Henes (Boxborough, Massachusetts) |
| ABSTRACT | The present application provides compounds and methods of treating viral infections, including viral infections caused by HIV or HTLV. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/334454 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6561 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371440 | BAZIN-LEE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium) |
| ASSIGNEE(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium) |
| INVENTOR(S) | Helene BAZIN-LEE (Hamilton, Montana) |
| ABSTRACT | The invention relates to a novel lipidated oxoadenine compound of formula (I) and its use as a vaccine adjuvant and as a TLR7 and/or TLR8 agonist. |
| FILED | Friday, April 12, 2019 |
| APPL NO | 17/043549 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 2039/55555 (20130101) Heterocyclic Compounds C07D 473/18 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/65616 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371460 | Wipf et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Peter Wipf (Pittsburgh, Pennsylvania); Marie-Celine Frantz (Seine Saint Denis, France) |
| ABSTRACT | Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/149565 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 47/64 (20170801) Acyclic or Carbocyclic Compounds C07C 237/16 (20130101) Heterocyclic Compounds C07D 209/44 (20130101) C07D 209/46 (20130101) C07D 211/58 (20130101) C07D 211/94 (20130101) C07D 221/22 (20130101) C07D 279/06 (20130101) C07D 401/12 (20130101) C07D 417/12 (20130101) C07D 471/08 (20130101) Peptides C07K 5/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371463 | Cai |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hua Cai (Los Angeles, California) |
| ABSTRACT | Disclosed herein are modified netrin-1 peptides and compositions thereof and methods of using thereof to confer cardioprotection. In some embodiments, the present invention provides methods of using one or more modified netrin-1 peptides and compositions thereof In some embodiments, the present invention provides a method of stimulating, increasing, or enhancing nitric oxide production by endothelial cells, which comprises administering to the endothelial cells one or more modified netrin-1 peptides or a composition thereof. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 17/286851 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371467 | MUIR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (, None) |
| INVENTOR(S) | Tom W. MUIR (Princeton, New Jersey); Adam J. STEVENS (Princeton, New Jersey); Neel H. SHAH (Berkeley, California) |
| ABSTRACT | Embodiments of the present invention relate to inteins, split inteins, compositions comprising inteins and methods for use of these. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/363698 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) Peptides C07K 14/001 (20130101) Original (OR) Class C07K 14/32 (20130101) C07K 16/2851 (20130101) C07K 2319/21 (20130101) C07K 2319/30 (20130101) C07K 2319/92 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371468 | Lindesmith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lisa Chon Lindesmith (Apex, North Carolina); Ralph Steven Baric (Haw River, North Carolina); Kari Moore Debbink (Ann Arbor, Michigan); Eric Francis Donaldson (Durham, North Carolina) |
| ABSTRACT | The present invention is directed to methods and compositions for norovirus therapeutics, such as vaccines, and diagnostics. |
| FILED | Thursday, October 18, 2018 |
| APPL NO | 16/756740 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/16022 (20130101) C12N 2770/16023 (20130101) C12N 2770/16034 (20130101) C12N 2770/36142 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371476 | Lohmueller |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Jason Lohmueller (Pittsburgh, Pennsylvania) |
| ABSTRACT | A chimeric antigen receptor is disclosed that includes: (a) an extracellular high affinity streptavidin; (b) a hinge domain from CD8; (c) a CD28 transmembrane domain; (d) an intracellular 4-1BB and/or CD28 signaling domain; and (e) an intracellular CD3 zeta signaling domain, wherein (a)-(e) are in N-terminal to C-terminal order. Nucleic acids encoding this chimeric antigen receptor, and T and natural killer (NK) cells transformed with this chimeric antigen receptor are also disclosed. The use of this chimeric antigen receptor for the treatment of tumors is also disclosed. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 17/398311 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/00 (20130101) A61K 39/0011 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Peptides C07K 14/36 (20130101) Original (OR) Class C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/2803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371479 | COHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Pinchas COHEN (Los Angeles, California); Kelvin YEN (Los Angeles, California) |
| ABSTRACT | Described herein is a novel, mitochondrial encoded, open reading frame, that leads to the production of a new mitochondrial peptide. Residing within the ND-Two subunit, a specific small nucleotide polymorphism disrupts expression of this mitochondrial peptide, and is correlated with an increase in obesity and diabetes, particularly in certain ethnic populations. In vitro administration of the peptide increases insulin secretion, decreases fat accumulation and improves glucose uptake in muscle cell. Antibodies generated against the peptide can be used for detecting peptide deficiency, in addition to SNP detection, supporting diagnostic approaches. In vivo studies further revealed that administration of the peptide improves glucose tolerance, thereby providing a new therapeutic avenue for a novel diabetes therapy and decreases bodyweight, thus serving as a novel obesity therapy. Generation of synthetic analogs further enhance or abrogated activity relative to the natural peptide. |
| FILED | Wednesday, August 04, 2021 |
| APPL NO | 17/394282 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/10 (20180101) Peptides C07K 7/08 (20130101) C07K 14/47 (20130101) Original (OR) Class C07K 14/435 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2800/04 (20130101) G01N 2800/042 (20130101) G01N 2800/044 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371481 | Ildefonso et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Cristhian J. Ildefonso (Gainesville, Florida); Alfred S. Lewin (Gainesville, Florida); Qiuhong Li (Gainesville, Florida) |
| ABSTRACT | The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or ocular inflammation. In an exemplary embodiment, a method is disclosed that involves administering an expression vector that delivers a secretable and cell penetrating CARD to a subject in need of treatment or prevention of age-related macular degeneration or another condition involving macular degeneration or ocular neovascularization. |
| FILED | Wednesday, March 17, 2021 |
| APPL NO | 17/204627 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 48/005 (20130101) Peptides C07K 14/4703 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371489 | WEISS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. WEISS (Indianapolis, Indiana) |
| ABSTRACT | A single-chain insulin analogues may comprise an insulin B-chain polypeptide sequence connected by a connecting polypeptide (or C-domain) sequence to an insulin A-chain polypeptide sequence. The connecting polypeptide sequence may be Glu-Xaa-Gly-Pro-Arg-Arg where Xaa is Glu or Ala. The insulin analogues may additionally comprise Glu or His substitutions at the position corresponding to A8 of human insulin and/or a Glu substitution at the position corresponding to A14 of human insulin. In some embodiments, the insulin analogues may additionally comprise either a Pro or Glu at the positions corresponding to B28 and B29 of wild-type insulin. Additional substitutions may comprise Phe or Trp at the position corresponding to A13 of wild type insulin and/or Gln, Arg, Phe, or Glu at the position corresponding to A17 of wild type insulin. In some embodiments, a Glu substitution at the position corresponding to B16 of wild type insulin may be present. In other embodiments, a Cys substitution may be present at the positions corresponding to A10 and/or B4 of wild-type insulin. In addition or in the alternative, the analogue may comprise a His or Ala substitution at the position corresponding to B22 of wild-type insulin and/or the connecting polypeptide sequence may be Glu-Glu-Gly-Pro-Ala-His. A method of treating a patient with diabetes mellitus comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient by means of intravenous, intraperitoneal, or subcutaneous injection. |
| FILED | Monday, September 23, 2019 |
| APPL NO | 17/277979 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371495 | June et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl H. June (Merion Station, Pennsylvania); John Scholler (Narberth, Pennsylvania); Avery D. Posey, JR. (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 17/444519 |
| CURRENT CPC | Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) Original (OR) Class C07K 14/70507 (20130101) C07K 16/30 (20130101) C07K 16/2803 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371498 | Sgourakis |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolaos G. Sgourakis (Philadelphia, Pennsylvania) |
| ABSTRACT | Compositions are provided that comprise peptide receptive MHC class I complexes (peptide receptive MHC-I complexes) that are formed after treatment with a catalytic amount of chaperone (i.e. a ratio of chaperone to MHC-I of less than 1:1). In particular, these peptide receptive MHC class I complexes can be used to form peptide-MHC class I (pMHC-I) multimers that can be used in high throughput applications such as detection of antigen specific T cells and characterization of T cell profiles in subjects. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/141096 |
| CURRENT CPC | Peptides C07K 1/00 (20130101) C07K 14/70539 (20130101) Original (OR) Class C07K 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371499 | SGOURAKIS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolaos G. SGOURAKIS (Philadelphia, California) |
| ABSTRACT | Compositions that include peptide receptive MEW class I complexes and methods of making and using such complexes are provided. In particular embodiments, such peptide receptive MHC class I complexes are used to form peptide MHC class I (pMHC-I) multimers useful for high throughput applications, such as, for the detection of antigen specific T cells and characterization of T cell profiles in subjects. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/233407 |
| CURRENT CPC | Peptides C07K 14/705 (20130101) C07K 14/70539 (20130101) Original (OR) Class C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371514 | Golde et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd Eliot Golde (Gainesville, Florida); Hunter S. Futch (Gainesville, Florida); Brenda Dawn Moore (Gainesville, Florida); Benoit Giasson (Gainesville, Florida) |
| ABSTRACT | Disclosed herein are materials and methods for the treatment of stress-related disorders and cancer. The disclosure provides an antibody, or antigen binding fragment thereof, that specifically binds to a region of corticotropin-releasing hormone (CRH). The disclosure also provides methods of treating a disorder associated with HPA axis activation, such as a stress-related disorder or cancer, comprising administering to a subject in need thereof an antibody or antigen binding fragment thereof described herein in an amount effective to treat the disorder. |
| FILED | Monday, June 10, 2019 |
| APPL NO | 16/973502 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/35 (20130101) A61K 47/6415 (20170801) A61K 47/6847 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/26 (20130101) Original (OR) Class C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371519 | Finkelman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF CINCINNATI (Cincinnati, Ohio); CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio); CHRISTIAN-ALBRECHTS-UNIVERSITAT ZU KIEL (Kiel, Germany) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fred Finkelman (Netanya, Israel); Suzanne Morris (Mason, Ohio); Marat Khodoun (Mason, Ohio); Crystal Potter (Fairfield, Ohio); Elizabeth Angerman (Fort Thomas, Kentucky); Andrew Herr (Cincinnati, Ohio); Matthias Peipp (Hamburg, Germany) |
| ABSTRACT | A monovalent monoclonal antibody is provided, the antibody including one light chain, one heavy chain, and one truncated heavy chain, wherein the truncated heavy chain lacks a variable domain and a CH1 domain and wherein the antibody specifically binds an epitope of FcεRIα. Also provided are methods of desensitizing a subject to an allergen, methods of treating an allergy, and methods of preventing an allergic reaction in a subject having an allergy. |
| FILED | Friday, September 20, 2019 |
| APPL NO | 17/277071 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) Peptides C07K 16/283 (20130101) Original (OR) Class C07K 2317/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371534 | Tomlinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); Universitat De Barcelona (Barcelona, Spain) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Tomlinson (Charleston, South Carolina); Ali Alawieh (Atlanta, Georgia); Pablo Engel (Barcelona, Spain) |
| ABSTRACT | The present invention describes compositions and methods for targeting complement inhibition to sites of p-selectin expression, and compositions for inhibiting p-selectin and complement. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335355 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 14/70596 (20130101) C07K 16/2854 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371542 | Ho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Mitchell Ho (Urbana, Maryland); Nan Li (Laurel, Maryland); Dan Li (Bethesda, Maryland) |
| ABSTRACT | Nucleic acid constructs encoding a chimeric antigen receptor (CAR) and a truncated human epidermal growth factor receptor (huEGFRt) are described. The encoded CARs include a tumor antigen-specific monoclonal antibody, such as a glypican-3 (GPC3)-specific, a GPC2-specific or a mesothelin-specific monoclonal antibody, fused to a CD8α hinge region, a CD8α transmembrane region, a 4-1BB co-stimulatory domain and a CD3ζ signaling domain. Isolated host cells, such as isolated T cells that co-express the disclosed CARs and huEGFRt are also described. T cells transduced with the disclosed CAR constructs can be used for cancer immunotherapy. |
| FILED | Wednesday, November 07, 2018 |
| APPL NO | 16/762459 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/71 (20130101) C07K 14/7051 (20130101) C07K 14/7153 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/303 (20130101) Original (OR) Class C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371645 | BECKER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Matthew BECKER (Chapel Hill, North Carolina); James A. WILSON (Wolverhampton, West Midlands, United Kingdom); Rodger A. DILLA (Akron, Ohio) |
| ASSIGNEE(S) | THE UNIVERSITY OF AKRON (Akron, None) |
| INVENTOR(S) | Matthew BECKER (Chapel Hill, North Carolina); James A. WILSON (Wolverhampton, West Midlands, United Kingdom); Rodger A. DILLA (Akron, Ohio) |
| ABSTRACT | In one or more embodiments, the present invention provides a low molecular weight, non-toxic, resorbable poly(ethylene glycol) (PEG)-block-poly(propylene fumarate) (PPF) diblock copolymers and poly(propylene fumarate) (PPF)-block-poly(ethylene glycol) (PEG)-block-poly(propylene fumarate) (PPF) triblock copolymers (and related methods for their making and use) that permits hydration for the formation of such things as hydrogels and has constrained and predictable material properties suitable for 3D printing and drug delivery applications. Using continuous digital light processing (cDLP) hydrogels the diblock and triblock copolymers can be photochemically printed from an aqueous solution into structures having a 10-fold increase in elongation at break compared to traditional diethyl fumarate (DEF) based printing. Furthermore, PPF-PEG-PPF triblock hydrogels have also been found in vitro to be biocompatible across a number of engineered MC3T3, NIH3T3, and primary Schwann cells. |
| FILED | Tuesday, August 07, 2018 |
| APPL NO | 16/637358 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/676 (20130101) C08G 65/10 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/075 (20130101) Compositions of Macromolecular Compounds C08L 67/06 (20130101) C08L 67/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371741 | Shenderova et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Olga A. Shenderova (Raleigh, North Carolina); Alexander M. Zaitsev (Staten Island, New York); Nicholas A. Nunn (Raleigh, North Carolina); Marco Diego Torelli (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Olga A. Shenderova (Raleigh, North Carolina); Alexander M. Zaitsev (Staten Island, New York); Nicholas A. Nunn (Raleigh, North Carolina); Marco Diego Torelli (Raleigh, North Carolina) |
| ABSTRACT | A method of controlled production of luminescent diamond particles exhibiting luminescence in selected specific spectral ranges is provided. The method comprises taking diamond particles containing dopant atoms in the diamond core, irradiating the particles with high energy radiation, and annealing the irradiated diamond particles at a target temperature in the temperature range of about 1400° C.-2200° C. to form luminescent diamond particles where the specific spectral range of luminescence is controlled by the target temperature of the annealing process, the irradiation dose, and the type of dopant atoms. Duration of the annealing and the temperature ramp up and ramp down times should be short enough to minimize or prevent significant graphitization of the particles. Duration of the temperature ramp up time should be short enough to minimize formation of color centers that might form at temperatures below the target temperature. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/233843 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/28 (20170801) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/65 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371782 | Parker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Kit Parker (Cambridge, Massachusetts); Janna C. Nawroth (Boston, Massachusetts); Lisa Scudder (Belmont, Massachusetts) |
| ABSTRACT | The present invention provides methods for optically micropatterning hydrogels, which may be used for, e.g., regenerative medicine, synthetic or cultured foods, and in devices suitable for use in high throughput drug screening assays. |
| FILED | Friday, August 04, 2017 |
| APPL NO | 16/322507 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/0006 (20130101) B23K 26/355 (20180801) B23K 2103/30 (20180801) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 23/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371783 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Indiana University (Indianapolis, Indiana) |
| ASSIGNEE(S) | The Trustees of Indiana University (Indianapolis, Indiana) |
| INVENTOR(S) | Lester Jeshua Smith (Maud, Texas); Brian Paul McCarthy (Indianapolis, Indiana); Mark Robert Holland (McCordsville, Indiana); Paul Richard Territo (Fishers, Indiana) |
| ABSTRACT | A bioreactor comprising a housing defining a perfusion chamber, the housing including at least one port, wherein the at least one port is coupled to the housing, and a sample holder positioned within the perfusion chamber. A bioreactor and spheroid-based biofabrication method for making perfusible tissue constructs and perfusing them. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/396816 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0247 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/38 (20130101) C12M 29/10 (20130101) C12M 41/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371786 | Bertassoni |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luiz E. Bertassoni (Portland, Oregon) |
| ABSTRACT | Disclosed is a microfluidic device having a channel a chamber in fluid communication with the channel. The chamber is sized to contain dental sample that is form a semipermeable barrier through which fluid from the channel is deliverable to the dental sample. |
| FILED | Thursday, October 03, 2019 |
| APPL NO | 17/282828 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0096 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 25/14 (20130101) C12M 29/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371815 | Holloway et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emily Holloway (Ann Arbor, Michigan); Jason Spence (Ann Arbor, Michigan) |
| ABSTRACT | The invention disclosed herein generally relates to methods and systems for converting stem cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the invention disclosed herein relates to methods and systems for promoting vascularized human intestinal organoid tissue having an intestine-specific EC transcriptional signature from hindgut spheroid tissue produced in vitro from the described methods. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332532 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Original (OR) Class C12N 2501/11 (20130101) C12N 2501/16 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) C12N 2501/165 (20130101) C12N 2501/999 (20130101) C12N 2513/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371832 | Donald et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce Donald (Durham, North Carolina); Anna Lowegard (Durham, North Carolina); Marcel Frenkel (Durham, North Carolina) |
| ABSTRACT | In some aspects, provided herein are computational methods for structure-based protein design. These new methods and incorporated algorithms speed-up computational structure-based protein design while maintaining accurate calculations, allowing for larger, previously infeasible protein designs. In another aspect, provided herein are mutant c-RAF proteins, and conjugates comprising the same. The conjugates may be used in methods of treating cancer in a subject, such as in methods of treating a KRas mutant cancer. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332338 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/66 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) G16B 30/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371879 | Flannery et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Novartis AG (Basel, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John G. Flannery (Berkeley, California); Scott F. Geller (El Cerrito, California); Karen I. Guerin (Braintree, Massachusetts) |
| ABSTRACT | The present disclosure provides recombinant adeno-associated virus (AAV) virions comprising: a) a variant capsid protein; and b) a heterologous nucleic acid comprising one or more nucleotide sequences encoding one or more heterologous gene products. The rAAV virions are useful for delivery of gene products to a retinal cell. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332855 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371904 | Troll et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dovetail Genomics, LLC (Scotts Valley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher John Troll (Santa Cruz, California); Martin P. Powers (San Francisco, California); Nicholas H. Putnam (Waltham, Massachusetts); Marco Blanchette (Santa Cruz, California); Paul Hartley (San Jose, California) |
| ABSTRACT | The disclosure provides methods to isolate genome or chromosome level structural information from preserved samples. In some cases, samples preserved under conditions where long-range nucleic acid information is believed to be irreparably lost, such as FFPE samples, are treated to recover nucleic acid-protein complexes stabilized as part of the sample preservation process. The complexes are processed so as to recover information regarding which nucleic acids are bound to a common complex, and the information is used to recover genomic structural information. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166394 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6816 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371905 | Haselton |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frederick R. Haselton (Nashville, Tennessee) |
| ABSTRACT | Disclosed herein is a COVID-19 surveillance method for detecting exhaled virions trapped within used face masks. This is a surveillance and warning system for identifying asymptomatic and pre-symptomatic individuals, particularly essential workers required to wear masks while at work. This can include healthcare workers, first responders, nursing home personnel, postal workers, or employees at meat packing and other production facilities. A piece of filter paper can be added to the inside of a standard face mask, which can be removed at the end of a shift. Mask inserts from a group of employees can be pooled and tested using standard RT-PCR for virions collected during normal exhalation over the time the mask is worn. As envisioned, if the group test is positive, additional follow-up or contact tracing could be initiated to identify the individual or individuals requiring treatment or quarantine. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331151 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/11 (20130101) A41D 2300/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/686 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371911 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | David Yu ZHANG (Houston, Texas); Juexiao WANG (Houston, Texas) |
| ABSTRACT | The present disclosure describes the thermodynamic design and concentrations necessary to design probe compositions with desired optimal specificity that enable enrichment, detection, quantitation, purification, imaging, and amplification of rare-allele-bearing species of nucleic acids (prevalence <1%) in a large stoichiometric excess of a dominant-allele-bearing species (wildtype). Being an enzyme-free and homogeneous nucleic acid enrichment composition, this technology is broadly compatible with nearly all nucleic acid-based biotechnology, including plate reader and fluorimeter readout of nucleic acids, microarrays, PCR and other enzymatic amplification reactions, fluorescence barcoding, nanoparticle-based purification and quantitation, and in situ hybridization imaging technologies. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/392168 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210371914 — METHODS AND COMPOSITIONS FOR IDENTIFYING OR QUANTIFYING TARGETS IN A BIOLOGICAL SAMPLE
| US 20210371914 | Stoeckius et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York Genome Center, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marlon Stoeckius (New York, New York); Peter Smibert (New York, New York); Brian Houck-Loomis (New York, New York) |
| ABSTRACT | Compositions, kits and methods are described that comprise one or more constructs, each construct comprising a ligand attached or conjugated to a polymer construct, e.g., an oligonucleotide sequence, by a linker, each ligand binding specifically to a single target located in or on the surface of a cell. The polymer construct comprises a) an Amplification Handle; b) a Barcode that specifically identifies a single ligand; c) an optional Unique Molecular Identifier that is positioned adjacent to the Barcode on its 5′ or 3′ end; and d) an Anchor for hybridizing to a complementary sequence, e.g., for generation of a double-stranded oligonucleotide. These compositions are used in methods, including high throughput methods, for detecting one or more targets or epitopes in a biological sample. These compositions are also used in a high throughput method for characterizing a cell by simultaneous detection of one or more epitopes located in or on the cell and its transcriptome. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245479 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6844 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 50/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371920 | SALK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse SALK (Seattle, Washington); Lawrence A. LOEB (Bellevue, Washington); Michael SCHMITT (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/392175 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371921 | SALK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse SALK (Seattle, Washington); Lawrence A. LOEB (Bellevue, Washington); Michael SCHMITT (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/392180 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371922 | SALK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse SALK (Seattle, Washington); Lawrence A. LOEB (Bellevue, Washington); Michael SCHMITT (Bellevue, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/392185 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371923 | SALK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse SALK (Seattle, Washington); Lawrence A. LOEB (Bellevue, Washington); Michael SCHMITT (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/392193 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371924 | SALK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse SALK (Seattle, Washington); Lawrence A. LOEB (Bellevue, Washington); Michael SCHMITT (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/392203 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371926 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Omar Abudayyeh (Cambridge, Massachusetts) |
| ABSTRACT | The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect both DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences, and includes detection by colorimetric and/or fluorescence shifts. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA. |
| FILED | Tuesday, January 29, 2019 |
| APPL NO | 16/961820 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 15/115 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) C12Q 1/6858 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372929 | Hariri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amani Hariri (Stanford, California); Constantin Dory (Stanford, California); Alyssa Cartwright (Stanford, California); Jelena Vuckovic (Stanford, California); Hyongsok Tom Soh (Stanford, California) |
| ABSTRACT | The disclosure provides an optical probe comprising an optical waveguide attached to a molecular switch that produces an altered optical signal upon binding a target molecule. The disclosure also provides an optical sensor system comprising an optical probe, a light source configured to emit the excitation light to be coupled into the optical waveguide of the optical probe; and a detector. |
| FILED | Wednesday, October 23, 2019 |
| APPL NO | 17/286912 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 5/1455 (20130101) A61B 5/6801 (20130101) A61B 5/6846 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/648 (20130101) G01N 21/6486 (20130101) Original (OR) Class G01N 2021/6441 (20130101) G01N 2021/6484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372948 | Lindner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott Eugene Lindner (State College, Pennsylvania); Susan Hafenstein (Lemont, Pennsylvania) |
| ABSTRACT | Provided are processes and materials for solving biological or structural information about proteins or other organic molecules. The processes capitalize on a rigid multimeric nanocage formed from self-assembling substructure proteins. The processes and materials allow for recognition and tight, optionally covalent, bonding of any protein molecule with a tag complementary to a capture sequence on the nanocage. The processes and materials may be used to obtain biological or structural information by cryo-electron microscopy and overcome prior limitations of target protein size or salt concentration. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399492 |
| CURRENT CPC | Peptides C07K 1/00 (20130101) C07K 14/47 (20130101) C07K 2319/23 (20130101) C07K 2319/50 (20130101) C07K 2319/80 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/04 (20130101) Original (OR) Class G01N 2223/612 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372959 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Chang Liu (Chapin, South Carolina); Qian Wang (Colurmbia, South Carolina) |
| ABSTRACT | The current disclosure provides a transformative concept based on nanopore technology, Sequencing-by-Hydrolysis, to identify the N-terminal amino acid and the length of each peptide fragment in a peptide ladder to reconstitute the sequence of a protein: a protein/peptide analyte will be nonspecifically hydrolyzed to generate random fragments of the analyte that are different by one amino acid with the N-terminal amino acid of each fragment modified so it generates a distinguishable fingerprint signal when tested by nanopore. The length of the fragment can be estimated by characterizing its translocation signal to back calculate the location of the amino acid in the original analyte. This approach will significantly advance the nanopore technology with single amino acid resolution for protein/peptide sequencing. |
| FILED | Thursday, March 25, 2021 |
| APPL NO | 17/212021 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/128 (20130101) Original (OR) Class G01N 33/6806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372986 | LINDSAY |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart LINDSAY (PHOENIX, Arizona) |
| ABSTRACT | The present disclosure provides devices, systems, and methods related to bioelectronic devices. In particular, the present disclosure provides bioelectronic devices, and methods of making bioelectronic devices, comprising adjustable adaptor polypeptides with repeatable motifs and enhanced conductive properties. The bioelectronic devices and methods of the present disclosure are useful for a variety of applications, including the direct measurement of protein activity (e.g., when sequencing a biopolymer). |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333087 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/3273 (20130101) G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372994 | Metzger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE ROCKEFELLER UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jakob Metzger (New York, New York); Fred Etoc (New York, New York); Ali Brivanlou (New York, New York); Eric Siggia (New York, New York) |
| ABSTRACT | Systems and methods for identifying molecules that are biologically active against a disease, where the method can comprise culturing a first mammalian cell population under organoid formation conditions in the presence of a test molecule to obtain a first organoid, wherein the first mammalian cell population, when cultured under the organoid formation conditions in the absence of the test molecule, results in an organoid with a disease phenotype; imaging the first organoid following exposure to the test molecule; analyzing one or more images of the first organoid using a neural network that has been trained to assign a probability score of disease or non-disease ranging between 0% and 100%; assigning the first organoid a probability score ranging between 0% and 100%; wherein the test molecule is biologically active against the disease if the probability score of the first organoid is greater than a cutoff probability score of non-disease or lower than a cutoff probability score of disease. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282039 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 2503/02 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 33/5014 (20130101) G01N 33/5076 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00147 (20130101) G06K 9/6256 (20130101) G06K 9/6262 (20130101) G06K 2209/05 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2200/04 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) G06T 2207/30072 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373014 | Alter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Galit Alter (Winchester, Massachusetts); Aniruddh Sarkar (Boston, Massachusetts); Jongyoon Han (Boston, Massachusetts) |
| ABSTRACT | A method for detection of antibodies in a biological sample. The method includes steps of: immobilizing antigens specific to the antibodies between at least two electrodes; binding the antibodies from the biological sample to the antigens; binding probes linked with an enzyme to the antibodies; exposing the enzyme to a metal substrate; depositing a metal layer based on exposing the enzyme to the metal substrate; measuring an electrical property of the metal layer between a first electrode of the at least two electrodes and a second electrode of the at least two electrodes; and detecting, based on measuring the electrical property of the metal layer, the antibodies in the biological sample. |
| FILED | Tuesday, October 23, 2018 |
| APPL NO | 16/758731 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 2300/0645 (20130101) B01L 2300/0883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5438 (20130101) G01N 33/5695 (20130101) Original (OR) Class G01N 2333/35 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373036 | SIERKS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael SIERKS (Ft. McDowell, Arizona); Stephanie WILLIAMS (Phoenix, Arizona); Lalitha VENKATARAMAN (Tempe, Arizona) |
| ABSTRACT | The invention relates to antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with frontotemporal dementia (FTD), but not TDP-43 associated with amyotrophic lateral sclerosis (ALS) or TDP-43 associated with healthy human brain tissue, and antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with ALS, but not TDP-43 associated FTD or TDP-43 associated with healthy human brain tissue. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242780 |
| CURRENT CPC | Peptides C07K 16/18 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/285 (20130101) G01N 2800/2814 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373037 | Demirci et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL (Boston, Massachusetts); BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); BETH ISRAEL DEACONESS MEDICAL CENTER (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Utkan Demirci (Stanford, California); Ionita Ghiran (Boston, Massachusetts); Savas Tasoglu (Storrs, Connecticut); Ronald W. Davis (Palo Alto, California); Lars Steinmetz (Palo Alto, California); Naside Gozde Durmus (Palo Alto, California); Huseyin Cumhur Tekin (Palo Alto, California) |
| ABSTRACT | Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/169765 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0656 (20130101) G01N 15/1031 (20130101) G01N 27/76 (20130101) G01N 33/80 (20130101) Original (OR) Class G01N 33/487 (20130101) G01N 33/491 (20130101) G01N 33/574 (20130101) G01N 2015/0053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373102 | Pang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuxi Pang (Superior Township, Michigan) |
| ABSTRACT | Techniques for analyzing ordered tissue to calculate an orientation-independent order parameter S that is sensitive to the collagen microstructural integrity in cartilage are provided. An magnetic resonance image of ordered tissue may be acquired, and based on the image, an R1ρ dispersion of the ordered tissue may be measured. R2a(α) and τb(α) values for the ordered tissue may be derived based on the measured R1ρ dispersion of the ordered tissue. An orientation-independent order parameter S may be calculated for the ordered tissue using the following equation: |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313591 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/4514 (20130101) A61B 5/4519 (20130101) A61B 5/4523 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373311 | HILLMAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Elizabeth M.C. HILLMAN (New York, New York) |
| ABSTRACT | A pulsed beam of NIR excitation light is projected into a sample at an oblique angle and scanned by a scanning element through a volume in the sample. 2-photon excitation excites fluorescence within the sample. The fluorescence is imaged onto an intermediate image plane that remains stationary regardless of the orientation of the scanning element. The image is captured by a linear array of light detecting elements or a linear portion of a rectangular array. At any given position of the scanning element, the linear array (or portion) images all depths simultaneously. A plurality of images are captured for each of a plurality of different orientations of the scanning element. The orientation of the scanning element is controlled to move in a two dimensional pattern, which causes the beam of excitation light to sweep out a three dimensional volume within the sample. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/341870 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 2201/0675 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) G02B 21/0048 (20130101) G02B 21/0076 (20130101) Original (OR) Class G02B 21/367 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374388 | Yu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Stowers Institute for Medical Research (Kansas City, Missouri) |
| ASSIGNEE(S) | Stowers Institute for Medical Research (Kansas City, Missouri) |
| INVENTOR(S) | Congrong (Ron) Yu (Leawood, Kansas); Rishabh Raj (Kansas City, Missouri); Dar Wilbur Dahlen (Albany, California) |
| ABSTRACT | This disclosure relates to the use of “pseudo-images” to perform image recognition, e.g., to perform facial image recognition. In an embodiment, the pseudo-image is obtained by starting with a real world image and, after optional preprocessing, subjecting the image to a non-linear transformation that converts the image into a pseudo-image. While real world objects (or, more generally, real world patterns) may be perceivable in the starting image, they cannot be perceived in the pseudo-image. Image recognition takes place by comparing the pseudo-image with a library of known pseudo-images, i.e., image recognition takes place in pseudo-image space without a return to real world space. In this way, robust image recognition is achieved even for imperfect real world images, such as, real world images that have been degraded by noise, poor illumination, uneven lighting, and/or occlusion, e.g., the presence of glasses, scarves, or the like in the case of facial images. |
| FILED | Saturday, August 07, 2021 |
| APPL NO | 17/396667 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/40 (20130101) G06K 9/00275 (20130101) G06K 9/00288 (20130101) Original (OR) Class G06K 9/4652 (20130101) G06K 9/4661 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374910 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pengfei Song (Champaign, Illinois); Shigao Chen (Rochester, Minnesota); Joshua D. Trzasko (Rochester, Minnesota); Armando Manduca (Rochester, Minnesota); Shanshan Tang (Rochester, Minnesota) |
| ABSTRACT | Described here are systems and methods for super-resolution imaging with ultrasound in which a Kalman filter-based microvessel inpainting technique is used to facilitate robust super-resolution imaging with limited or otherwise missing microbubble signals. The systems and methods described in the present disclosure can be combined with both local and global microbubble tracking methods. |
| FILED | Friday, October 18, 2019 |
| APPL NO | 17/286681 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/481 (20130101) A61B 8/0891 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/52026 (20130101) G01S 7/52041 (20130101) G01S 15/89 (20130101) Image Data Processing or Generation, in General G06T 3/4007 (20130101) G06T 3/4053 (20130101) Original (OR) Class G06T 5/002 (20130101) G06T 7/277 (20170101) G06T 2207/10132 (20130101) G06T 2207/20182 (20130101) G06T 2207/30101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374953 | Asiedu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mercy Asiedu (Durham, North Carolina); Nirmala Ramanujam (Durham, North Carolina); Guillermo Sapiro (Durham, North Carolina) |
| ABSTRACT | A method for automated detection of cervical pre-cancer includes: providing at least one cervigram; pre-processing the at least one cervigram; extracting features from the at least one pre-processed cervigram; and classifying the at least one cervigram as negative or positive for cervical pre-cancer based on the extracted features. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282093 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/136 (20170101) G06T 7/168 (20170101) G06T 2207/20024 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20132 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375407 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai Wang (Princeton, New Jersey); Chunhua Weng (New York, New York) |
| ABSTRACT | Disclosed are methods, devices, systems, circuits, media, and other implementations that include a method including accessing electronic health record data for a patient, performing natural language processing on the electronic health record data to extract biomedical concepts, processing the biomedical concepts to obtain phenotype terms, normalizing the phenotype terms to generate normalized phenotype terms, and identifying based on the normalized phenotype terms one or more candidate genes responsible for one or more medical conditions causing at least some of the biomedical concepts extracted from the electronic health record data. |
| FILED | Tuesday, October 02, 2018 |
| APPL NO | 16/648336 |
| CURRENT CPC | Electric Digital Data Processing G06F 40/10 (20200101) G06F 40/30 (20200101) G06F 40/40 (20200101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 50/10 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) Original (OR) Class G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375459 | Longmire et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Medable Inc. (Palo Alto, California) |
| ASSIGNEE(S) | Medable Inc. (Palo Alto, California) |
| INVENTOR(S) | Michelle Longmire (PALO ALTO, California); Ingrid Oakley-Girvan (Henderson, California); NICK MOSS (Los Alamos, New Mexico); Reem Yunis (Menlo Park, California); Anushka Manoj Gupta (RALEIGH, North Carolina) |
| ABSTRACT | The instant system and method will be a scalable and flexible software platform to agnostically capture wearable, implantable, or external device data and create a digital biomarker for various disease conditions, care and analysis. The system and method also provides an informatics tool for automated data aggregation, integration, and machine learning algorithms to uniformly compare/contrast/couple data streams as a function of patient and context over time. The focus is on user engagement and usability, accessibility and reporting to the clinical care team, and usability by researchers interested in analyzing data and outcomes. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/219867 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/00 (20180101) G16H 40/67 (20180101) G16H 50/20 (20180101) Original (OR) Class G16H 50/50 (20180101) G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375480 | Mahon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradford Mahon (Pittsburgh, Pennsylvania); Keith Parkins (Rochester, New York); Max Sims (Rochester, New York); Benjamin Chernoff (Pittsburgh, Pennsylvania); Hugo Angulo-Orquera (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system for outputting a visual representation of a brain of a patient is configured to receive sensor data representing a behavior of a region of the brain of the patient. The system retrieves mapping data that maps a prediction value to the region. The prediction value is indicative of an effect on a behavior of the patient responsive to a treatment of the region, the mapping data being indexed to a patient identifier. The system receives, responsive to an application of a stimulation to the region, sensor data representing behavior of the region. The system executes a model that updates, based on the sensor data, the prediction value for the region. The system updates, responsive to executing the model, the mapping data by including the updated prediction value in the mapping data. The system outputs a visual representation of the updated mapping data comprising the updated prediction value. |
| FILED | Monday, December 02, 2019 |
| APPL NO | 17/272603 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/0077 (20130101) A61B 5/372 (20210101) A61B 5/4803 (20130101) A61B 34/10 (20160201) A61B 2034/105 (20160201) A61B 2034/107 (20160201) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 15/00 (20180101) G16H 20/30 (20180101) G16H 20/40 (20180101) G16H 30/20 (20180101) G16H 30/40 (20180101) G16H 40/67 (20180101) G16H 50/20 (20180101) G16H 50/70 (20180101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/91 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376660 | Chakrabartty et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shantanu Chakrabartty (St. Louis, Missouri); Yarub Alazzawi (St. Louis, Missouri); Kenji Aono (St. Louis, Missouri); Erica L. Scheller (St. Louis, Missouri) |
| ABSTRACT | A self-capacitance based remote power delivery device includes a power source, an energy harvesting device, and a substrate. The power source and the energy harvesting device are configured to be capacitively coupled to a self-capacitive body. The substrate is configured to be capacitively coupled to a portion of the self-capacitive body in contact with the substrate. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/395704 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/05 (20160201) Original (OR) Class Transmission H04B 5/0012 (20130101) H04B 5/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210369160 | ANDESHMAND et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Talis Biomedical Corporation (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sayeed ANDESHMAND (Dublin, California); Thomas H. CAULEY, III (Redwood City, California); John DIXON (Moss Beach, California); David GLADE (San Ramon, California); Hédia MAAMAR (El Dorado Hills, California); Michael John McADAMS (Los Gatos, California); Dzam-Si Jesse NG (Fremont, California); David Alexander ROLFE (San Francisco, California) |
| ABSTRACT | Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230804 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/150755 (20130101) A61B 5/150961 (20130101) Original (OR) Class Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369747 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lingyin LI (Stanford, California); Mark SMITH (San Francisco, California); Kelsey Erin SHAW (Atlanta, Georgia); Jacqueline Ann CAROZZA (Stanford, California); Volker BOEHNERT (Palo Alto, California) |
| ABSTRACT | Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with a ENPP1 inhibitor to inhibit cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor is cell impermeable. Also provided are compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of a ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject either before or after administering an ENPP1 inhibitor. The radiation therapy can be administered at a dosage and/or frequency effective to reduce radiation damage to the subject. In certain cases, the method is performed in combination with a chemotherapeutic agent, or a checkpoint inhibitor, or both. |
| FILED | Friday, September 07, 2018 |
| APPL NO | 16/645300 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369807 | Farrow et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); Indi Molecular, Inc. (Culver City, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Blake Farrow (Pasadena, California); James R. Heath (South Pasadena, California); Heather Dawn Agnew (Culver City, California) |
| ABSTRACT | The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/322493 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/005 (20130101) Original (OR) Class A61K 38/06 (20130101) A61K 38/08 (20130101) A61K 38/12 (20130101) A61K 47/60 (20170801) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/008 (20130101) C07B 2200/05 (20130101) Peptides C07K 5/0808 (20130101) C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 7/52 (20130101) C07K 2319/01 (20130101) C07K 2319/70 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/531 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370135 | Hagen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Joshua Hagen (Cincinnati, Ohio); Gurtej S. Grewal (Beavercreek, Ohio) |
| ABSTRACT | Systems and methods for predicting/optimizing physical performance for a future event including selecting performance parameters indicative of performance for the future event, collecting data for the performance parameters and training parameters for past events, comparing the collected data for determining which training parameters are statistically significant to the performance parameters, and providing a training program for manipulating the training parameters to optimize performance for the future event. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400565 |
| CURRENT CPC | Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 24/0062 (20130101) Original (OR) Class A63B 2024/0065 (20130101) A63B 2024/0068 (20130101) A63B 2230/065 (20130101) Electric Digital Data Processing G06F 1/163 (20130101) G06F 16/90335 (20190101) G06F 17/18 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/04 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) G16H 20/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371295 | Ravichandran |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duraiswamy Ravichandran (College Station, Texas) |
| ASSIGNEE(S) | Texas Biochemicals Inc. (College Station, Texas) |
| INVENTOR(S) | Duraiswamy Ravichandran (College Station, Texas) |
| ABSTRACT | A method is provided for producing an article which is transparent to near-wave IR, mid-wave and Long-wave multi-spectral and IR wavelength in the region of 0.4 pm to 16 μm. The method includes the steps of (a) Producing ultra-fine powder of CaLa2S4 via SPLTS process, (b) followed by pretreatment of the ultra-fine powder under inert and reducing gas conditions including H2 or Argon or N2 or H2/H2S, H2S, and mixtures there of (c) followed by sieving the powder in 140 mesh screen and cold pressing the powder at 7000 psi for 7 min. into a disk shaped green body (d) then Cold-Isostatic Pressing (CIP) at 40,000 psi for 5 min in a rubber mold (e) finally sintered article of CaLa2S4 disk of 25.4 mm diameter with ultra-high density containing cubic phase of CaLa2S4 to yield IR transmission of a peak value of 57% within the IR wavelength range of 2 μm to 16 μm, either by using microwave sintering followed by hot isostatic press or spark plasma sintering followed by hot isostatic press or vacuum sintering at (3×10−6 torr) followed by hot isostatic press or hot press sintering followed by hot isostatic press and finally followed by mirror polished IR article, is obtained. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/101767 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 3/003 (20130101) B28B 11/243 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 9/08 (20130101) C01G 11/02 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2004/03 (20130101) C01P 2004/61 (20130101) C01P 2004/64 (20130101) C01P 2006/60 (20130101) C01P 2006/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371592 | Zafiropoulos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aspen Aerogels, Inc. (Northborough, Massachusetts) |
| ASSIGNEE(S) | Aspen Aerogels, Inc. (Northborough, Massachusetts) |
| INVENTOR(S) | Nicholas Anthony Zafiropoulos (Wayland, Massachusetts); Shannon Olga White (Hudson, Massachusetts); Jimmy Lee Clark (Newhall, California) |
| ABSTRACT | The present invention provides compositions and methods related to aerogel materials, including polyimide-based aerogels. In particular, aerogel materials optimized to have certain physical and chemical properties such as flexural and compressive strength are provided. In some embodiments, the aerogel materials can be at least partially carbonized. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/360296 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/04 (20130101) B32B 3/266 (20130101) B32B 5/10 (20130101) B32B 5/18 (20130101) B32B 5/32 (20130101) B32B 27/281 (20130101) B32B 2266/04 (20130101) B32B 2266/06 (20130101) B32B 2266/057 (20161101) B32B 2266/102 (20161101) B32B 2266/126 (20161101) B32B 2266/0214 (20130101) B32B 2266/0292 (20130101) B32B 2307/72 (20130101) B32B 2307/302 (20130101) B32B 2307/304 (20130101) B32B 2307/416 (20130101) B32B 2307/546 (20130101) B32B 2605/18 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/10 (20130101) Original (OR) Class C08G 73/1067 (20130101) C08G 2110/0091 (20210101) C08G 2330/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/04 (20130101) C08K 7/06 (20130101) Compositions of Macromolecular Compounds C08L 79/08 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 59/028 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/233 (20150115) Y10T 428/249953 (20150401) Y10T 428/249986 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371782 | Parker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Kit Parker (Cambridge, Massachusetts); Janna C. Nawroth (Boston, Massachusetts); Lisa Scudder (Belmont, Massachusetts) |
| ABSTRACT | The present invention provides methods for optically micropatterning hydrogels, which may be used for, e.g., regenerative medicine, synthetic or cultured foods, and in devices suitable for use in high throughput drug screening assays. |
| FILED | Friday, August 04, 2017 |
| APPL NO | 16/322507 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/0006 (20130101) B23K 26/355 (20180801) B23K 2103/30 (20180801) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/16 (20130101) C12M 23/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371790 | MACQUEEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luke A. MACQUEEN (Cambridge, Massachusetts); Kevin Kit PARKER (Cambridge, Massachusetts); Josue A. GOSS (Cambridge, Massachusetts); Christophe CHANTRE (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods are provided including a housing configured to receive and engage a hollow tissue structure within a fluid chamber of the housing. A first pair of flow channels and a second pair of flow channels of the housing are fluidly coupled to the fluid chamber. The housing fluidly couples the first pair of flow channels and fluidly couples the second pair of flow channels via a second flow path such that a change in a fluid pressure differential between a first fluid in the first flow path and a second fluid in the second flow path deflects at least a portion of the hollow tissue structure causing a change in flow of the first fluid through the first pair of flow channels or a change in flow of the second fluid through the second pair of flow channels. |
| FILED | Tuesday, February 05, 2019 |
| APPL NO | 16/968178 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/20 (20130101) C12M 25/14 (20130101) Original (OR) Class C12M 29/00 (20130101) C12M 41/44 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0652 (20130101) C12N 5/0697 (20130101) C12N 2503/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371821 | Kim |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Chan Kim (Rockville, Maryland) |
| ABSTRACT | The present disclosure provides methods for producing cell populations enriched for induced regulatory T cells (iTregs). In particular, the disclosure relates to methods for culturing T cells such that the final culture is enriched for induced regulatory T cells. The disclosure also relates to methods for inducing regulatory T cells. Also provided are compositions enriched for induced regulatory T cells, which are useful for treating individuals in need of such treatment. The methods and compositions disclosed herein can also be used to treat individuals suffering from immune-mediated diseases. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335808 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) Original (OR) Class C12N 2500/40 (20130101) C12N 2501/15 (20130101) C12N 2501/2302 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371856 | CHAIKIND et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian CHAIKIND (Oakland, California); Hendrik Marinus VAN ROSSUM (Oakland, California) |
| ABSTRACT | Methods, compositions, and kits for high throughput DNA assembly reactions in vitro. Modular CRISPR DNA constructs comprising modular insert DNA parts flanked by cloning tag segments comprising pre-validated CRISPR protospacer/protospacer adjacent motif sequence combinations. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392366 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/66 (20130101) C12N 15/1003 (20130101) C12N 2310/20 (20170501) C12N 2310/3517 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371926 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Omar Abudayyeh (Cambridge, Massachusetts) |
| ABSTRACT | The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect both DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences, and includes detection by colorimetric and/or fluorescence shifts. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA. |
| FILED | Tuesday, January 29, 2019 |
| APPL NO | 16/961820 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 15/115 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) C12Q 1/6858 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372052 | HU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liangbing HU (Rockville, Maryland); Zhiqiang FANG (Hyattsville, Maryland); Hongli ZHU (College Park, Maryland) |
| ABSTRACT | Solar cell substrates require high optical transparency, but also prefer high optical haze to increase the light scattering and consequently the absorption in the active materials. Unfortunately, there is a tradeoff between these optical properties, which is exemplified by common transparent paper substrates exhibiting a transparency of about 90% yet a low optical haze (<20%). In this work we introduce a novel transparent paper made of wood fibers that display both ultra-high optical transparency (˜96%) and ultra-high haze (˜60%), thus delivering an optimal substrate design for solar cell devices. Compared to previously demonstrated nanopaper composed of wood-based cellulose nanofibers, our novel transparent paper has better dual performance in transmittance and haze, but also is fabricated at a much lower cost. This high-performance, low-cost transparent paper is a potentially revolutionary material that may influence a new generation of environmentally friendly printed electronics. |
| FILED | Wednesday, March 24, 2021 |
| APPL NO | 17/210849 |
| CURRENT CPC | Pulp Compositions; Preparation Thereof Not Covered by Subclasses D21C or D21D; Impregnating or Coating of Paper; Treatment of Finished Paper Not Covered by Class B31 or Subclass D21G; Paper Not Otherwise Provided for D21H 17/07 (20130101) Original (OR) Class D21H 17/66 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/04 (20130101) H01L 31/048 (20130101) H01L 31/02168 (20130101) H01L 51/44 (20130101) H01L 51/0097 (20130101) Climate Change Mitigation Technologies Related to Buildings, e.g Housing, House Appliances or Related End-user Applications Y02B 10/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372377 | McAleenan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KAZAK TECHNOLOGIES, INC. (Woolwich, Maine) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael McAleenan (Woolwich, Maine) |
| ABSTRACT | Flywheel system properties are enhanced with rim designs that control stress at operational rotational velocities. The tensile strength of fiber-resin composites can be aligned with radial forces to improve radial stress loading. Loops with composite casings can be arranged around the flywheel circumference with a majority of the fibers being aligned in the radial direction. The loops can enclose masses that contribute to energy storage in the flywheel system. Masses can be arranged around the hub circumference with a hoop wound composite casing enclosing the masses and hub. The masses subjected to radial forces are radially displaced with increasing rotational velocity and can provide compressive force to the fiber-resin composite to contribute to maintaining composite integrity. With the alignment of fibers in hoop or radial directions, higher loading permits increase rotational velocities, which can significantly add to the amount of energy stored or produced with the flywheel. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242748 |
| CURRENT CPC | Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 3/08 (20130101) Original (OR) Class Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 32/0474 (20130101) Dynamo-electric Machines H02K 7/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372444 | Staidl et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Casey J. Staidl (Virginia Beach, Virginia); Jerrod K. Jenkins (Cypress, Texas); Ashley N. Figert (Virginia Beach, Virginia) |
| ABSTRACT | A clip holding an adapter housing to a radio includes an antenna end having an outer ring and annular inner ring shallower than the outer ring, thereby collectively forming an L-shaped annular cross-section defining an annular seat on an interior portion of the antenna end; an adapter end includes a partial annular ring with a break opening the ring away from the antenna end, thereby forming a clip which is configured to releasably retain an adapter housing cord; and a connecting portion rigidly coupling the antenna end to the adapter end. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/337109 |
| CURRENT CPC | Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 2/22 (20130101) Original (OR) Class Transmission H04B 1/3833 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372501 | Esplin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger C. Esplin (Marana, Arizona); Peter H. Vo (Oro Valley, Arizona) |
| ABSTRACT | A low-profile shock isolating payload mounting assembly comprises a first mount, a second mount, and an isolator. The second mount is movable relative to the first mount and comprises a riser comprising an inclined surface. The isolator comprises an inner frame and an outer frame. The inner frame couples to the first mount and comprises a platform and a leg extending from the platform. The leg is inclined to be complementary to the inclined surface of the second mount. The outer frame couples to the second mount and comprises an opening for accessing the platform of the inner frame. The rail is inclined so as to be complementary to the leg to capture the leg between the rail of the outer frame and the inclined surface of the second mount. The isolator operates to dampen vibrations and shocks propagating between the first and second mounts. |
| FILED | Tuesday, May 26, 2020 |
| APPL NO | 16/883912 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 5/1208 (20130101) Springs; Shock-absorbers; Means for Damping Vibration F16F 15/022 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372718 | Ayotte et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Textron Systems Corporation (Hunt Valley, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Michael Ayotte (Acworth, Georgia); Andrew Joseph Bosley (Catonsville, Maryland); Ed Charles Volz (Rosedale, Maryland); Leonard Terrence Katilas (Essex, Maryland) |
| ABSTRACT | A feed tray assembly for a belt-fed weapon includes a bottom tray portion configured for mounting at a top of the weapon. The feed tray assembly further includes a feed tray cover mounted to the bottom tray portion and configured for lateral sliding opening and closing movement, such as on laterally extending pins riding in corresponding channels of the bottom tray portion. The feed tray cover has (1) a closed position in which it covers the bottom tray portion to retain the belt of ammunition during operation, and (2) an open position laterally displaced from the closed position to enable insertion of the belt of ammunition. Due to this lateral sliding movement of the feed tray cover, a sighting optic may be mounted on the weapon with a forward portion directly above the feed tray assembly without any undesired mechanical interference. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/331781 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 3/66 (20130101) Original (OR) Class F41A 9/29 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372779 | DeWeert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Michael J. DeWeert (Kaneohe, Hawaii); Eric M. Louchard (Miami, Florida); Reid A. Noguchi (Honolulu, Hawaii); Dugan C. Yoon (Honolulu, Hawaii) |
| ABSTRACT | Systems and methods for three-dimensional (3D) shape estimation of objects embedded in light-scattering media via polarimetry are provided. The systems and methods utilize polarization to exploit forward scattering in the light-scattering medium to mitigate backscatter interference (BSI). |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 16/885739 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/24 (20130101) Original (OR) Class G01B 11/168 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 4/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372881 | Walters et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LSP Technologies, inc. (Dublin, Ohio) |
| ASSIGNEE(S) | LSP Technologies, inc. (Dublin, Ohio) |
| INVENTOR(S) | Craig T. Walters (Powell, Ohio); David Sokol (Dublin, Ohio) |
| ABSTRACT | Systems, methods and device provided for combining or splitting laser beams, including a plurality of optical fibers for providing laser beams, an image relay lens for each of the plurality of optical fibers, positioning a prism beam combiner or splitter after the image relay lenses for combining or splitting the laser beams. According to another aspect, the a prism beam combiner or splitter may include a flattened tip to transmit a portion of an input laser beam, a position sensitive detector to receive the transmitted portion of the input laser beam to track a beam axis motion and provide feedback alignment error signals based on the beam axis motion, and a driver to receive the feedback alignment error signals and to drive a motor or piezo actuated beam steering minor based on the feedback alignment error signals, wherein a laser bond inspection method implements the described systems and methods. |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 17/281627 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 11/37 (20130101) G01M 11/088 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 6/04 (20130101) G02B 6/4214 (20130101) G02B 6/4296 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372921 | Burns et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennie Burns (San Antonio, Texas); Joel Bixler (San Antonio, Texas) |
| ABSTRACT | A digital speckle pattern interferometer (DSPI) is provided for long-range measurement of displacement of materials within a hazardous environments. A test arm of a portion of coherent beam from a laser is aimed at a selected angle to traverse a distance to a test surface. An input collimator has a lens wide enough to receive a reflected beam from the test surface and is focused at a corresponding distance. The reflected beam is combined with a reference beam split from the coherent radiation onto a camera for measuring displacement of the test surface based on an electronic speckle pattern interferometer (ESPI). |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335804 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Original (OR) Class G01N 2201/08 (20130101) G01N 2201/0633 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372969 | Giurgiutiu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Victor Giurgiutiu (Columbia, South Carolina); Robin James (Columbia, South Carolina); Roshan Joseph (Columbia, South Carolina) |
| ABSTRACT | Employing methodologies and systems to detect damage initiation and growth inside a composite material (matrix cracking, delamination, fiber break, fiber pullout, etc.) wherein damage produces high-frequency acoustic emission (AE) waves that are transported to recording sensors along with relatively lower frequency waves representing the flexural deformation of the impacted composite structure. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/101049 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/14 (20130101) Original (OR) Class G01N 29/22 (20130101) G01N 29/4472 (20130101) G01N 2291/0231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372971 | Lobkis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Etegent Technologies, Ltd. (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oleg Lobkis (Mason, Ohio); Richard A. Roth (Goshen, Ohio); Christopher G. Larsen (Cincinnati, Ohio); Stuart J. Shelley (Cincinnati, Ohio) |
| ABSTRACT | An environmental condition may be measured with a sensor (10) including a wire (20) having an ultrasonic signal transmission characteristic that varies in response to the environmental condition by sensing ultrasonic energy propagated through the wire using multiple types of propagation, and separating an effect of temperature on the wire from an effect of strain on the wire using the sensed ultrasonic energy propagated through the wire using the multiple types of propagation. A positive feedback loop may be used to excite the wire such that strain in the wire is based upon a sensed resonant frequency, while a square wave with a controlled duty cycle may be used to excite the wire at multiple excitation frequencies. A phase matched cone (200, 210) may be used to couple ultrasonic energy between a waveguide wire (202, 212) and a transducer (204, 214). |
| FILED | Monday, November 30, 2020 |
| APPL NO | 17/107646 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 17/02 (20130101) F01D 17/085 (20130101) Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 11/00 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/10 (20130101) G01L 11/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/07 (20130101) G01N 29/12 (20130101) G01N 29/326 (20130101) Original (OR) Class G01N 29/2462 (20130101) G01N 2291/0421 (20130101) G01N 2291/0426 (20130101) G01N 2291/0427 (20130101) G01N 2291/02827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372982 | Rubeinstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | H Mitchell Rubeinstein (Beavercreek, Ohio); Christin M Duran (Dyton, Ohio); Daniel O Reilley (Kettering, Ohio); Steven D Fisher (Dayton, Ohio); Anthony V Qualley (Washington Township, Ohio) |
| ABSTRACT | A self-timing, passive, chemical dosimeter. The dosimeter includes a sampling media and electronics supported by a cassette. The sampling media is configured to absorb volatile organic compounds, semivolatile organic compounds, or both, while the electronics are configured to record a time of exposure. The dosimeter further includes an actuator having a closed position and an open position. In the closed position, the actuator resists exposure of the sampling media to volatile organic compounds, semivolatile organic compounds, or both, and in the open position, the actuator permits exposure of the sampling media to volatile organic compounds, semivolatile organic compounds, or both. The actuator is configured to operate the electronics for recording time of exposure. |
| FILED | Wednesday, May 27, 2020 |
| APPL NO | 16/884711 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0062 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373002 | Gopinath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); UNIVERSITY OF BRITISH COLUMBIA (Vancouver, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashwin Gopinath (Cambridge, Massachusetts); Christopher Thachuk (Seattle, Washington); David G. Kirkpatrick (Vancouver, Canada); Paul W. Rothemund (Pasadena, California) |
| ABSTRACT | According to one embodiment of the present invention, a structure includes: a substrate having a patterned surface of one or more binding sites; and a molecular shape made by a polynucleotide platform having a shape corresponding to a shape of a binding site of the one or more binding sites, the molecular shape being bound to one of the one or more binding sites. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/396477 |
| CURRENT CPC | Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 50/18 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6445 (20130101) G01N 33/548 (20130101) Original (OR) Class G01N 33/54373 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373180 | KASSAS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Zak KASSAS (Irvine, California); Kimia SHAMAEI (Irvine, California) |
| ABSTRACT | This disclosure is directed to sub-meter level navigation accuracy for Unmanned Aerial Vehicles (UAVs) using broadband communication signals, such as cellular long-term evolution (LTE) signals. A framework and methods are provided using a receiver and controller to produce at least one of carrier phase, code phase, and Doppler frequency measurements from received LTE signals. Single difference measurements may be used to remove clock bias. LTE ENodeB clock biases are initialized using the known initial position of the UAV. The measurements are fused via an extended Kalman filter (EKF) to estimate the UAV position and integer ambiguities of the carrier phase single difference measurements. LTE signals can have different carrier frequencies and conventional algorithms do not estimate the integer ambiguities. Processes are described to detect cycle slip, where the carrier phase measurements from the LTE eNodeB multiple antenna ports are used to detect cycle slip. |
| FILED | Tuesday, November 03, 2020 |
| APPL NO | 17/088232 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/37 (20130101) G01S 19/44 (20130101) Original (OR) Class G01S 19/51 (20130101) G01S 19/393 (20190801) Systems for Controlling or Regulating Non-electric Variables G05D 1/101 (20130101) Electric Digital Data Processing G06F 17/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373236 | JIANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linan JIANG (Tucson, Arizona); Stanley K.H. PAU (Tucson, Arizona); Robert A. Norwood (Tucson, Arizona) |
| ABSTRACT | A method of forming an optical interconnect between first and second photonic chips located on an optical printed circuit board includes applying a flexible, freestanding film onto the first and second chips so that the film extends over a gap and/or step between the chips. The film includes a photosensitive layer having a refractive index that decreases by exposure to radiation and a backing layer. The film is exposed to a flood exposure having a radiation dosage penetrating the backing layer and only a surface sublayer of the photosensitive layer. After curing the film, the backing layer is removed so that the photosensitive layer remains on the first and second chips. The photosensitive layer is selectively exposed to a second radiation dosage to define waveguide core(s) in unexposed regions of the photosensitive layer below the surface sublayer. The photosensitive layer is heated to cure the selectively exposed portions. |
| FILED | Tuesday, February 26, 2019 |
| APPL NO | 16/975819 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/43 (20130101) G02B 6/138 (20130101) Original (OR) Class G02B 6/305 (20130101) G02B 6/428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373338 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Magic Leap, Inc. (Plantation, Florida) |
| ASSIGNEE(S) | Magic Leap, Inc. (Plantation, Florida) |
| INVENTOR(S) | Chunyu Gao (Tucson, Arizona); Yuxiang LIN (Tucson, Arizona); Hong HUA (Tucson, Arizona) |
| ABSTRACT | The present invention comprises a compact optical see-through head-mounted display capable of combining, a see-through image path with a virtual image path such that the opaqueness of the see-through image path can be modulated and the virtual image occludes parts of the see-through image and vice versa. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127316 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 13/06 (20130101) G02B 25/001 (20130101) G02B 27/144 (20130101) G02B 27/0172 (20130101) Original (OR) Class G02B 27/283 (20130101) G02B 27/1066 (20130101) Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 37/02 (20130101) Image Data Processing or Generation, in General G06T 19/006 (20130101) Pictorial Communication, e.g Television H04N 5/2258 (20130101) H04N 5/23238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373358 | Dhinojwala et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Akron (Akron, Ohio) |
| ASSIGNEE(S) | The University of Akron (, None) |
| INVENTOR(S) | Ali Dhinojwala (Akron, Ohio); Saranshu Singla (Sangruer, Indiana) |
| ABSTRACT | In various embodiments, the present invention is directed to contact lenses that utilize a multilayer coating of alternating high RI materials, such as melanin or polydopamine (PDA) and other low RI materials to create tunable iridescent colors and contain melanin or similar materials that impart photoprotection due to their broadband UV-vis absorption spectrum and ability to quench radicals. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/215546 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/005 (20130101) B05D 1/18 (20130101) B05D 3/002 (20130101) B05D 3/007 (20130101) B05D 3/144 (20130101) B05D 3/145 (20130101) B05D 5/06 (20130101) B05D 7/52 (20130101) B05D 2518/00 (20130101) Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 69/104 (20130101) Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 7/049 (20130101) Original (OR) Class G02C 2202/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373413 | Popovic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); University of Colorado (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milos A. Popovic (Boston, Massachusetts); Jeffrey Michael Shainline (Lafayette, Colorado); Jason Orcutt (Katonah, New York); Vladimir Marko Stojanovic (Berkeley, California) |
| ABSTRACT | An optical modulator is disclosed that includes an optical resonator structure. The optical resonator structure includes at least one non-linear portion, the at least one non-linear portion comprising at least one radial junction region. The at least one radial junction region is formed between at least first and second materials, respectively, having different electronic conductivity characteristics. A principal axis of the at least one radial junction region is oriented along a radius of curvature of the at least one non-linear portion. The optical modulator includes an optical waveguide that is coupled to the at least one non-linear portion of the optical resonator structure. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/239963 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/2938 (20130101) G02B 6/29338 (20130101) G02B 6/29395 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/025 (20130101) G02F 1/2257 (20130101) Original (OR) Class G02F 1/3509 (20210101) G02F 2201/17 (20130101) G02F 2203/05 (20130101) G02F 2203/07 (20130101) G02F 2203/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373987 | Raghavendra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramya Raghavendra (New york, New York); MUDHAKAR SRIVATSA (White Plains, New York); Joshua M. Rosenkranz (White Plains, New York); Pranita Sharad Dewan (White Plains, New York) |
| ABSTRACT | Aspects of the invention include generating a vector representation of a root node of the error based on a hierarchical topology of a computing system; generating a respective vector representations of each subject matter expert of a plurality of subject matter experts based at least in part on the hierarchical topology; selecting a subject matter expert based at least in part on the vector representation of root cause of the error; and uploading a diagnostic software to the computing system. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 16/885482 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/079 (20130101) Original (OR) Class G06F 11/302 (20130101) G06F 16/322 (20190101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6215 (20130101) G06K 9/6262 (20130101) Computer Systems Based on Specific Computational Models G06N 5/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374351 | Livingston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. Livingston (Silver Spring, Maryland); Derek Brock (Arlington, Virginia); Jonathan W. Decker (Burtonsville, Maryland); Dennis J. Perzanowski (Burke, Virginia); Christopher Van Dolson (Alexandria, Virginia); Joseph Matthews (Laurel, Maryland); Alexander Lulushi (Oakton, Virginia) |
| ABSTRACT | Systems and methods are provided for generating queries suitable for evaluating graph comprehension capability. Embodiments of the present disclosure are based on the Sentence Verification Technique (SVT), an empirically validated framework for measuring an individual's comprehension of prose material. Compared to ad hoc methods for testing graph comprehension, embodiments of the present disclosure are less subjective, require less manual effort and subject matter expertise, and address the essential features of a given graph: values and relationships depicted, frames of reference, and style attributes. Embodiments of the present disclosure combat superficial comprehension by testing what the reader has encoded, as opposed to testing the reader's ability at visual recall or ability to look up data without reaching real comprehension. |
| FILED | Monday, June 01, 2020 |
| APPL NO | 16/889070 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/903 (20190101) G06F 16/9024 (20190101) G06F 40/30 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374953 | Asiedu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mercy Asiedu (Durham, North Carolina); Nirmala Ramanujam (Durham, North Carolina); Guillermo Sapiro (Durham, North Carolina) |
| ABSTRACT | A method for automated detection of cervical pre-cancer includes: providing at least one cervigram; pre-processing the at least one cervigram; extracting features from the at least one pre-processed cervigram; and classifying the at least one cervigram as negative or positive for cervical pre-cancer based on the extracted features. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282093 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/136 (20170101) G06T 7/168 (20170101) G06T 2207/20024 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20132 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375112 | Spoor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zahid F. Mian (, None) |
| ASSIGNEE(S) | Zahid F. Mian (Troy, New York) |
| INVENTOR(S) | Ryk E. Spoor (Troy, New York); Zahid F. Mian (Loudonville, New York) |
| ABSTRACT | A system, and method for measuring biological and or other data of a target user or subject. In the preferred embodiment, the invention uses infrared imaging to obtain a temperature image of a diver's eye and analyzes the image to determine the diver's core temperature nonintrusively. The preferred embodiment may also include other sensors to monitor the diver's physical condition and circumstances, and can report anomalies to both the diver and a more remote interested party, such as a dive master. In the preferred embodiment, sensors and interfaces are connected to a central processing unit by underwater transmission, such as by short wavelength radio, while the remote party communicates with the system, such as by acoustic signal transmission. |
| FILED | Wednesday, April 14, 2021 |
| APPL NO | 17/230569 |
| CURRENT CPC | Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/182 (20130101) G08B 21/0453 (20130101) G08B 21/0476 (20130101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375533 | Raju |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ravisekhar Nadimpalli Raju (Clifton Park, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravisekhar Nadimpalli Raju (Clifton Park, New York) |
| ABSTRACT | A transformer with improved insulation structure is provided which includes an insulating sheet separating the primary-side windings and portion of split magnetic core from the secondary-side windings and portion of split magnetic core. Thin layers of conductive and semiconductive material are deposited on areas of the insulating sheet surfaces facing the primary and secondary sides. These layers are electrically referenced or tied to the potentials of the respective primary or secondary sides. This ensures that the high electric field due to primary-to-secondary potential gradient is substantially placed across the insulating sheet dielectric and avoided in the air gaps or voids in the transformer, thus reducing undesirable partial discharge effects. The two core sections on the primary and secondary side are also electrically referenced or tied to the potentials of their adjacent windings, thus reducing high electric fields and partial discharge in the space between the core sections and the windings. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/156959 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/324 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375680 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Travis J. Anderson (Alexandria, Virginia); Marko J. Tadjer (Vienna, Virginia); Karl D. Hobart (Alexandria, Virginia) |
| ABSTRACT | Methods for obtaining a free-standing thick (>5 μm) epitaxial material layer or heterostructure stack and for transferring the thick epitaxial layer or stack to an arbitrary substrate. A thick epitaxial layer or heterostructure stack is formed on an engineered substrate, with a sacrificial layer disposed between the epitaxial layer and the engineered substrate. When the sacrificial layer is removed, the epitaxial layer becomes a thick freestanding layer that can be transferred to an arbitrary substrate, with the remaining engineered substrate being reusable for subsequent material layer growth. In an exemplary case, the material layer is a GaN layer and can be selectively bonded to an arbitrary substrate to selectively produce a Ga-polar or an N-polar GaN layer. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/327816 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/406 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0242 (20130101) H01L 21/0254 (20130101) H01L 21/02568 (20130101) H01L 21/4807 (20130101) H01L 21/7813 (20130101) Original (OR) Class H01L 23/3732 (20130101) H01L 29/24 (20130101) H01L 29/872 (20130101) H01L 29/2003 (20130101) H01L 29/7786 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376214 | Czubarow et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | eM-TECH (Wellesley, Massachusetts) |
| ASSIGNEE(S) | eM-TECH (Wellesley, Massachusetts) |
| INVENTOR(S) | Pawel Czubarow (Wellesley, Massachusetts); Anthony Nicholas Czubarow (Wellesley, Massachusetts); Philip Abraham Premysler (Falls Church, Virginia) |
| ABSTRACT | Methods of making various fibers are provided including co-axial fibers with oppositely doped cladding and core are provide; hollow core doped silicon carbide fibers are provided; and doubly clad PIN junction fibers are provided. Additionally methods are provided for forming direct PN junctions between oppositely doped fibers are provided. Various thermoelectric generators that incorporate the aforementioned fibers are provided. |
| FILED | Monday, August 17, 2020 |
| APPL NO | 16/995582 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 41/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/20 (20130101) H01L 35/30 (20130101) H01L 35/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376463 | Massman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey P. Massman (Centerville, Ohio) |
| ABSTRACT | A phased array antenna system having radiating units unitarily formed and arranged in an array by direct metal sintering avoiding assembly requirements. Each radiating unit includes a free-space impedance transformer having first, second and third radiator elements. Each radiating unit includes an embedded balun having first, second, and third impedance transition elements located generally concentric with the first, the second, and the third radiator elements and distally connected respectively to form a first integrated coaxial interface, a second integrated coaxial interface, and an integrated ground interface. Each radiating unit includes a ground plane electrically coupled to the integrated ground interface. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332438 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/48 (20130101) H01Q 3/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376484 | ELSALLAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The MITRE Corporation (McLean, Virginia); The Government of the United States of America, as Represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia); The Government of the United States of America, as Represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Wajih ELSALLAL (Acton, Massachusetts); Jamie HOOD (Owatonna, Minnesota); Al LOCKER (Westford, Massachusetts); Rick W. KINDT (Arlington, Virginia) |
| ABSTRACT | A phased array antenna that includes a base plate; first and second spaced apart radiating elements formed by at least one conductive layer disposed on at least one dielectric layer that projects from the base plate; and a pillar disposed between the first and second spaced apart radiating elements, wherein the pillar is electrically connected to the base plate, and the first and second spaced apart radiating elements are configured to capacitively couple to the pillar. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397519 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/48 (20130101) H01Q 5/25 (20150115) H01Q 21/24 (20130101) H01Q 21/061 (20130101) Original (OR) Class H01Q 21/064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376551 | Gattass et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafael R. Gattass (Washington, District of Columbia); Colin C. Baker (Alexandria, Virginia); Augustus Xavier Carlson (Churchville, Maryland); L. Brandon Shaw (Woodbridge, Virginia); Jasbinder S. Sanghera (Ashburn, Virginia) |
| ABSTRACT | An apparatus includes an amplified spontaneous emission source, which in turn includes an optical fiber. The optical fiber includes a solid core and a first end. The solid core includes a silica matrix. The silica matrix includes a rare-earth element and a glass co-dopant. The rare-earth element includes dysprosium or neodymium. The glass co-dopant includes Al2O3. The apparatus further includes a laser pump diode coupled to the first end of the optical fiber. The laser pump diode and the optical fiber cooperate to generate a spontaneous spectral emission confined to the solid core. The spontaneous spectral emission includes a simultaneous plurality of spectral regions. |
| FILED | Wednesday, August 19, 2020 |
| APPL NO | 16/996975 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0941 (20130101) H01S 3/06712 (20130101) H01S 3/06716 (20130101) H01S 3/06795 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376610 | Kuznetsov |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Kuznetsov (Marlborough, Massachusetts) |
| ABSTRACT | A system includes a source configured to provide power to a medium-voltage direct current (MVDC) bus. The system also includes a plurality of rotating electrical machines configured to receive the power from the MVDC bus. The rotating electrical machines are arranged in a cascaded configuration. One of the rotating electrical machines is configured to act as a slave to another of the rotating electrical machines. Each rotating electrical machine is mechanically connected to an inertial energy storage. The system further includes a plurality of isolated battery or ultra-capacitor subsystems electrically connected to each rotating electrical machine. The battery or ultra-capacitor subsystems are configured to receive electrical energy from and provide electrical energy to each rotating electrical machine and the connected inertial energy storage. |
| FILED | Wednesday, November 04, 2020 |
| APPL NO | 17/089671 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/30 (20130101) Original (OR) Class H02J 3/32 (20130101) H02J 7/0068 (20130101) H02J 7/1423 (20130101) Dynamo-electric Machines H02K 7/025 (20130101) Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 25/22 (20130101) Pulse Technique H03K 3/57 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376949 | Chamberlain et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Roger Chamberlain (St. Louis, Missouri); Darko Ivanovich (St. Louis, Missouri); Viktor Gruev (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Roger Chamberlain (St. Louis, Missouri); Darko Ivanovich (St. Louis, Missouri); Viktor Gruev (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of systems or methods for polarization division multiplexed (PDM) optical transmission. For example, the PDM optical transmission system can comprise a chip with one or more aluminum nanowire filters attached to the surface of the chip, such as division of focal Plane (DoFP) polarimeter filter array bonded on the receiver IC. |
| FILED | Monday, January 27, 2020 |
| APPL NO | 16/773951 |
| CURRENT CPC | Multiplex Communication H04J 14/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210377042 | VALDEZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ENRIQUILLO VALDEZ (QUEENS, New York); RICHARD H. BOIVIE (MONROE, Connecticut); VENKATA SITARAMAGIRIDHARGANESH GANAPAVARAPU (PEEKSKILL, New York); JINWOOK JUNG (WHITE PLAINS, New York); GI-JOON NAM (CHAPPAQUA, New York); ROMAN VACULIN (LARCHMONT, New York); JAMES THOMAS RAYFIELD (RIDGEFIELD, Connecticut) |
| ABSTRACT | A method verifies an authenticity, integrity, and provenance of outputs from steps in a process flow. One or more processor(s) validate one or more inputs to each step in a process flow by verifying at least one of a hash and a digital signature of each of the one or more inputs. The processor(s) then generate digital signatures that cover outputs of each step and the one or more inputs to each step, such that the digital signatures result in a chain of digital signatures that are used to verify an authenticity, an integrity and a provenance of outputs of the one or more steps in the process flow. |
| FILED | Wednesday, May 27, 2020 |
| APPL NO | 16/884623 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/6218 (20130101) G06F 30/398 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0637 (20130101) H04L 9/3247 (20130101) Original (OR) Class H04L 2209/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210377452 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTELLIGENT FUSION TECHNOLOGY, INC. (Germantown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhonghai WANG (Germantown, Maryland); Xingping LIN (Germantown, Maryland); Genshe CHEN (Germantown, Maryland); Khanh PHAM (Kirtland AFB, New Mexico); Erik BLASCH (Arlington, Virginia) |
| ABSTRACT | An apparatus includes a camera for capturing an image at a first moment; a range finder for measuring a distance to an object at a center of the image; a rotatable mounting platform, fixedly hosting the camera and the range finder; and a controller. The controller is configured to receive the captured image and the measured distance; determine whether a target of interest (TOI) appears in the image; in response to determining a TOI appearing in the image, determine whether the TOI appears at the center of the image; calculate position parameters of the rotatable mounting platform for centering the TOI in an image to be captured at a second moment, separated from the first moment by a pre-determined time interval; control the rotatable mounting platform to rotate according to the calculated position parameters; and calculate and store the position parameters of the TOI with respect to the apparatus. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 16/890675 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Pictorial Communication, e.g Television H04N 5/33 (20130101) H04N 5/23299 (20180801) Original (OR) Class H04N 5/225251 (20180801) H04N 5/232125 (20180801) H04N 5/232127 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210377763 | TIAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTELLIGENT FUSION TECHNOLOGY, INC. (Germantown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xin TIAN (Germantown, Maryland); Yi LI (Germantown, Maryland); Genshe CHEN (Germantown, Maryland); Khanh PHAM (Kirtland AFB, New Mexico); Erik BLASCH (Arlington, Virginia) |
| ABSTRACT | Various embodiments of the present disclosure provide a method, a device, and a storage medium for performance prediction of a communication waveform in a communication system. The method includes measuring, by a receiver, an actual SNR distribution of a communication link between a transmitter and the receiver; further includes evaluating, by a waveform performance prediction device, a normalized minimum SNR shift required for the communication waveform to operate, where the normalized minimum SNR shift is obtained based on a normalized SNR distribution using a neural network (NN), the normalized SNR distribution corresponding to the actual SNR distribution; and further includes, according to the normalized minimum SNR shift, obtaining, by a waveform performance prediction device, an actual minimum SNR shift for the actual SNR distribution, where according to the actual minimum SNR shift, the communication system is adjusted for operation. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332534 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Wireless Communication Networks H04W 24/08 (20130101) Original (OR) Class H04W 52/241 (20130101) H04W 72/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378114 | McDowell |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CACI, Inc. - Federal (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David McDowell (Arlington, Virginia) |
| ABSTRACT | The present application describes apparatuses, systems, and methods for robust, adaptable, and deployable computing devices and radio systems. In one aspect, the present application describes a chassis for housing electronic componentry. The chassis includes a frame with a top plate and a bottom plate, an interface panel located on the chassis frame; a back panel located on the chassis frame opposite the interface panel, and a protective protrusion located at a corner of the chassis frame extending beyond the top plate and the bottom plate. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245003 |
| CURRENT CPC | Springs; Shock-absorbers; Means for Damping Vibration F16F 15/02 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 5/04 (20130101) H05K 5/023 (20130101) H05K 5/0204 (20130101) H05K 5/0213 (20130101) Original (OR) Class H05K 5/0247 (20130101) H05K 7/20145 (20130101) H05K 7/20336 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210369232 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | WEI CHEN (Wexford, Pennsylvania); WEI GAO (Mars, Pennsylvania); ERICK FORNO (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of estimating a number of lung function indices of an individual. The method includes: transmitting an ultrasound signal toward a chest of the individual from a speaker of a smartphone while the individual is holding the smartphone in a hand of the individual; receiving in a microphone of the smartphone a reflected signal reflected from the chest of the individual in response to the ultrasound signal; extracting a number of features from the reflected signal; and providing the number of features to a neural network regression model, wherein the neural network regression model estimates the number of lung function indices based on the number of features and based on a non-linear correlation between chest wall motion and human lung function. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333748 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/6898 (20130101) A61B 5/7203 (20130101) A61B 5/7225 (20130101) A61B 5/7264 (20130101) A61B 5/7475 (20130101) A61B 7/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369537 | Witte et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirby Ann Witte (Pittsburgh, Pennsylvania); Rachel W. Jackson (Pittsburgh, Pennsylvania); Steven H. Collins (Pittsburgh, Pennsylvania) |
| ABSTRACT | This document describes an exoskeleton device that includes a cable, a lever that is connected to the cable, a frame comprising a strut that redirects the cable toward the lever, wherein the frame is coupled to the lever by a rotational joint; and a motor that is connected to the cable and configured to cause the cable to provide a torque about the rotational joint, wherein the cable is configured to provide the torque by exerting a first force on the lever and a second force on the frame, and wherein the cable is further configured to provide the torque in a first rotational direction and is prevented from applying the torque in an opposite rotational direction to the first rotational direction. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184109 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1038 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0266 (20130101) A61H 3/00 (20130101) Original (OR) Class A61H 2201/12 (20130101) A61H 2201/50 (20130101) A61H 2201/165 (20130101) A61H 2201/1642 (20130101) A61H 2201/5061 (20130101) A61H 2201/5092 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 1/14 (20130101) F16C 2316/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369632 | Bahal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raman Bahal (Glastonbury, Connecticut); Mu-Ping Nieh (Mansfield, Connecticut); Armin Tahmasbi Rad (Manchester, Connecticut); Shipra Malik (Storrs, Connecticut) |
| ABSTRACT | A self-assembled discoidal PNA delivery vehicle includes a zwitterionic short chain diacyl lipid, a zwitterionic long chain diacyl lipid, a charged long chain diacyl lipid, a PEGylated lipid of the formula distearoyl phosphoethanolamine (DSPE)-PEGn-TG, and an encapsulated PNA molecule with a defined molar ratio of the zwitterionic long chain diacyl lipid and the charged long chain diacyl lipid to the short chain diacyl lipid, the molar ratio of the charged long chain diacyl lipid to the zwitterionic long chain diacyl lipid, molar % of the PEGylated lipid to all lipids, and ratio of PNA to lipid. Also described are method of self-assembling the discoidal PNA delivery vehicle and methods of enhancing cellular uptake of PNA using the discoidal PNA delivery vehicle. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332258 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 9/5192 (20130101) A61K 47/26 (20130101) A61K 47/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369864 | Lowe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Christopher Lowe (Piscataway, New Jersey); David I. Shreiber (Whitehouse Station, New Jersey); Emily DiMartini (Brick Township, New Jersey); Adam Gormley (New Brunswick, New Jersey) |
| ABSTRACT | The present invention provides a biocompatible conjugate for treating a disease or an injury. The conjugate contains a polymer covalently linked to one or more moieties each containing a polymerizable functional group. The conjugate forms a cross-linked polymer network after being exposed to an elevated level of free radicals associated with the disease or injury. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 17/398606 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/10 (20130101) A61K 47/34 (20130101) A61K 47/6935 (20170801) Original (OR) Class Compositions of Macromolecular Compounds C08L 33/06 (20130101) C08L 33/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369914 | KUMTA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | PRASHANT N. KUMTA (PITTSBURGH, Pennsylvania); JINGYAO WU (PITTSBURGH, Pennsylvania); OLEG VELIKOKHATNYI (PITTSBURGH, Pennsylvania) |
| ABSTRACT | The invention relates to compositions including magnesium-lithium alloys containing various alloying elements suitable for medical implant devices. The devices may be constructed of the compositions or have applied thereto a coating formed therefrom. Within the structure of the magnesium-lithium alloy, there is a co-existence of alpha and beta phases. The invention also relates to methods of preparing the magnesium-lithium alloys and articles, such as medical implant devices, for use in medical applications, such as but not limited to, orthopedic, dental, craniofacial and cardiovascular surgery. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381445 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/30 (20130101) Original (OR) Class A61L 27/047 (20130101) A61L 27/54 (20130101) A61L 27/306 (20130101) A61L 31/16 (20130101) A61L 31/022 (20130101) A61L 31/082 (20130101) A61L 31/088 (20130101) A61L 2300/102 (20130101) Alloys C22C 23/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370122 | Mohieldin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Dartmouth College (Hanover, New Hampshire); Mary Hitchcock Memorial Hospital, for itself and on behalf of Dartmouth Hitchcock Clinic (Lebanon, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suehayla Mohieldin (Bethesda, Maryland); Ryan J. Halter (Lyme, New Hampshire); John A. Batsis (Chapel Hill, North Carolina); Colin Minor (Southport, North Carolina); Curtis Lee Petersen (Portland, Oregon) |
| ABSTRACT | Devices and methods are disclosed for remote clinical monitoring performance of exercises using a smart resistance exercise device including a resistance band, a first handle connected to a first end of the resistance band and a second handle connected to a second end of the resistance band, a force sensing assembly operably coupled to the resistance band, and a local receiving device communicatively coupled to the force sensing assembly. The force sensing assembly of the device includes a housing, and a force sensor disposed in the housing and operatively connected to the resistance band to measure a force exerted on the resistance band. The force sensing assembly also includes a processing and communication module communicatively coupled to the force sensor to receive measurements of the force sensor and communicatively coupled to the local receiving device to transmit the measurements to the local receiving device. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335986 |
| CURRENT CPC | Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 21/00043 (20130101) Original (OR) Class A63B 2220/51 (20130101) A63B 2220/58 (20130101) A63B 2220/833 (20130101) A63B 2225/20 (20130101) A63B 2225/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370205 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yin Wang (Whitefish Bay, Wisconsin); Shangping Xu (Mequon, Wisconsin); Haiyan Yang (Milwaukee, Wisconsin); John Bender (Milwaukee, Wisconsin) |
| ABSTRACT | A filter material composing a ceramic clay having an interconnected network of pores formed from cellulose fiber combustion is useful for removing chemical and biological contaminants from a water supply. Coating the ceramic clay with lanthanum enhances the removal of anionic species of As(V), As(III), Cr(VI), microbes and virus. |
| FILED | Thursday, October 17, 2019 |
| APPL NO | 17/286124 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/022 (20130101) Separation B01D 39/06 (20130101) Original (OR) Class B01D 39/2082 (20130101) B01D 2239/10 (20130101) B01D 2239/125 (20130101) B01D 2239/0283 (20130101) B01D 2239/0407 (20130101) B01D 2239/0442 (20130101) B01D 2239/1208 (20130101) B01D 2239/1216 (20130101) B01D 2239/1233 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/001 (20130101) C02F 2101/103 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 33/04 (20130101) C04B 33/32 (20130101) C04B 33/1305 (20130101) C04B 38/0051 (20130101) C04B 38/0675 (20130101) C04B 2235/349 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370240 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manish Kumar (Austin, Texas); Woochul Song (State College, Pennsylvania); Yue-xiao Shen (EI Cerrito, California); Chao Lang (State College, Pennsylvania) |
| ABSTRACT | The present invention relates to a thin-film composite (TFC) membrane composition comprising macrocycles. The invention also relates in part to a method of fabricating a TFC membrane and to a method of using the TFC membrane to separate a desired liquid or gas from a liquid or gas mixture. |
| FILED | Wednesday, October 02, 2019 |
| APPL NO | 17/282082 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 67/0006 (20130101) B01D 69/02 (20130101) B01D 69/105 (20130101) B01D 69/125 (20130101) Original (OR) Class B01D 71/56 (20130101) B01D 71/60 (20130101) B01D 71/64 (20130101) B01D 71/68 (20130101) B01D 2325/02 (20130101) B01D 2325/04 (20130101) Acyclic or Carbocyclic Compounds C07C 7/144 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370241 | Bhattacharyya et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dibakar Bhattacharyya (Lexington, Kentucky); Anthony Saad (Lexington, Kentucky); Rollie Mills (Lexington, Kentucky); Lindell Ormsbee (Lexington, Kentucky); M. Abdul Mottaleb (Lexington, Kentucky) |
| ABSTRACT | Purification devices and methods remove perfluorinated compounds (PFCs) from PFC-contaminated water using temperature swing adsorption and desorption. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 16/885369 |
| CURRENT CPC | Separation B01D 69/125 (20130101) B01D 69/147 (20130101) Original (OR) Class B01D 71/34 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/267 (20130101) B01J 20/321 (20130101) B01J 20/2805 (20130101) B01J 20/3483 (20130101) B01J 20/28047 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/285 (20130101) C02F 1/288 (20130101) C02F 2101/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370272 | Ghosh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anindya Ghosh (Little Rock, Arkansas); Bijay P. Chhetri (Little Rock, Argentina) |
| ABSTRACT | A method of synthesizing a doped carbonaceous material includes mixing a carbon precursor material with at least one dopant to form a homogeneous/heterogeneous mixture; and subjecting the mixture to pyrolysis in an inert atmosphere to obtain the doped carbonaceous material. A method of purifying water includes providing an amount of the doped carbonaceous material in the water as a photocatalyst; and illuminating the water containing the doped carbonaceous material with visible light such that under visible light illumination, the doped carbonaceous material generates excitons (electron-hole pairs) and has high electron affinity, which react with oxygen and water adsorbed on its surface forming reactive oxygen species (ROS), such as hydroxyl radicals and superoxide radicals, singlet oxygen, hydrogen peroxide, that, in turn, decompose pollutants and micropollutants. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400255 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/18 (20130101) Original (OR) Class B01J 21/063 (20130101) B01J 21/066 (20130101) B01J 23/06 (20130101) B01J 23/10 (20130101) B01J 23/14 (20130101) B01J 23/22 (20130101) B01J 23/26 (20130101) B01J 23/28 (20130101) B01J 23/30 (20130101) B01J 23/36 (20130101) B01J 23/72 (20130101) B01J 23/75 (20130101) B01J 23/462 (20130101) B01J 23/745 (20130101) B01J 23/755 (20130101) B01J 27/04 (20130101) B01J 27/043 (20130101) B01J 27/047 (20130101) B01J 27/051 (20130101) B01J 31/182 (20130101) B01J 31/183 (20130101) B01J 31/1815 (20130101) B01J 31/1825 (20130101) B01J 31/2213 (20130101) B01J 35/004 (20130101) B01J 37/04 (20130101) B01J 37/084 (20130101) B01J 2231/005 (20130101) B01J 2531/008 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/30 (20130101) C02F 1/32 (20130101) C02F 1/283 (20130101) C02F 1/725 (20130101) C02F 2101/308 (20130101) C02F 2305/10 (20130101) C02F 2305/023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370301 | Tse et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CytoVale Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Henry Tat Kwong Tse (San Francisco, California); Ajay M. Shah (San Francisco, California); Lionel Guillou (San Francisco, California); Roya Sheybani (San Francisco, California); Christopher Dahlberg (San Francisco, California); Anne E. Jensen (San Francisco, California) |
| ABSTRACT | A system and method for determining a trajectory parameter of particles, comprising receiving a plurality of particles at a microfluidic channel, applying a force to each particle of the microfluidic channel, acquiring a dataset of each particle, measuring a trajectory of the particle, and determining a trajectory parameter of the particles. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401627 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502746 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2200/0631 (20130101) B01L 2200/0652 (20130101) B01L 2200/0668 (20130101) B01L 2200/0684 (20130101) B01L 2200/0694 (20130101) B01L 2300/185 (20130101) B01L 2300/0877 (20130101) B01L 2300/0887 (20130101) B01L 2400/0409 (20130101) B01L 2400/0415 (20130101) B01L 2400/0436 (20130101) Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/30024 (20130101) G06T 2207/30104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370586 | NUSSBAUM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin NUSSBAUM (Knoxville, Tennessee); Nathan Brad CRANE (Lutz, Florida) |
| ABSTRACT | The disclosed subject matter relates to method for increasing the molecular weight of a polymer material during an additive manufacturing process. The method can comprise disposing a first layer of the polymer material at a target surface; exposing the first layer of the polymer material to an energy source for a sufficient period of time to sinter or melt and undergo a condensation reaction at least at a portion of the polymer material; controlling the condensation reaction to allow a desired increased number average molecular weight of the polymer material; and repeating the method steps to form an object in a layerwise fashion. Controlling the condensation reaction can comprise controlling and/or adjusting an energy 10 source-related parameter, a polymer-related parameter, a temperature related parameter, a vacuum related parameter, a process duration, a processing gas, an air flow volume and/or speed, or a combination thereof. |
| FILED | Monday, July 22, 2019 |
| APPL NO | 17/277949 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Original (OR) Class B29C 64/245 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/10 (20200101) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371280 | Yao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Yunxi Yao (Pasadena, California); Konstantinos P. Giapis (Pasadena, California) |
| ABSTRACT | Apparatus and methods for facilitating an intramolecular reaction that occurs in single collisions of CO2 molecules (or their derivatives amenable to controllable acceleration, such as CO2+ ions) with a solid surface, such that molecular oxygen (or its relevant analogs, e.g., O2+ and O2− ions) is directly produced are provided. The reaction is driven by kinetic energy and is independent of surface composition and temperature. The methods and apparatus may be used to remove CO2 from Earth's atmosphere, while, in other embodiments, the methods and apparatus may be used to prevent the atmosphere's contamination with CO2 emissions. In yet other embodiments, the methods and apparatus may be used to obtain molecular oxygen in CO2-rich environments, such as to facilitate exploration of extraterrestrial bodies with CO2-rich atmospheres (e.g. Mars). |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397826 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 13/0203 (20130101) Original (OR) Class C01B 32/05 (20170801) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 5/04 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371296 | Weller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jon Weller (Phoenix, Arizona); Candace Chan (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jon Weller (Phoenix, Arizona); Candace Chan (Phoenix, Arizona) |
| ABSTRACT | Fabricating a layer including lithium lanthanum zirconate (Li7La3Zr2O12) layer includes forming a slurry including lanthanum zirconate (La2Zr2O7) nanocrystals, a lithium precursor, and a lanthanum precursor in stoichiometric amounts to yield a dispersion including lithium, lanthanum, and zirconium. In some cases, the dispersion includes lithium, lanthanum, and zirconium in a molar ratio of 7:3:2. In certain cases, the slurry includes excess lithium. The slurry is dispensed onto a substrate and dried. The dried slurry is calcined to yield the layer including lithium lanthanum zirconate. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/396967 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/006 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/52 (20130101) C01P 2002/60 (20130101) C01P 2004/03 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/09 (20130101) C08K 5/053 (20130101) Compositions of Macromolecular Compounds C08L 29/14 (20130101) C08L 33/08 (20130101) C08L 33/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371938 | Knight et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Biota Technology, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rob Knight (San Diego, California); Ajay Kshatriya (Oakland, California); Chris Lauber (Boulder, Colorado); J. Gregory Caporaso (Flagstaff, Arizona); Dan Knights (St. Paul, Minnesota); Ryan Gill (Denver, Colorado); Joel Moxley (Highlands Ranch, Colorado) |
| ABSTRACT | There are provided methods, systems and processes for the utilization of microbial and related genetic information for use in industrial settings, such as the exploration, determination, and recovery of natural resources, minerals, and energy sources, the monitoring and analysis of processes, activities, and materials transmission. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245822 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/582 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6888 (20130101) Original (OR) Class C12Q 2600/156 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/16 (20130101) E21B 47/11 (20200501) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 10/00 (20190201) G16B 20/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371987 | Dayeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shadi A. Dayeh (San Diego, California); Mehran Ganji (San Diego, California) |
| ABSTRACT | A method for fabricating a Pt nanorod electrode array sensor device includes forming planar metal electrodes on a flexible film, co-depositing Pt alloy on the planar metal electrodes via physical vapor deposition, and dealloying the Pt alloy to etch Pt nanorods from the deposited Pt alloy. A Pt nanorod electrode sensor device includes a plurality of porous Pt nanorods on a planar metal electrode forming a sensor electrode. The planar metal electrode is on a flexible substrate. An electrode lead on the flexible substrate extends away from the planar metal electrode. Insulation is around porous Pt nanorods an upon the electrode lead. |
| FILED | Thursday, November 07, 2019 |
| APPL NO | 17/291236 |
| CURRENT CPC | Alloys C22C 5/04 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/16 (20130101) C23C 14/5873 (20130101) Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25 C23F 1/02 (20130101) Original (OR) Class Electric Digital Data Processing G06F 3/015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372502 | Rahmatalla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ActiBioMotion, LLC (Coralville, Iowa); University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Salam Rahmatalla (Coralville, Iowa); Eric C. Frick (Coralville, Iowa); Charles W. Harris, JR. (Coralville, Iowa); Varun Chalasani (Coralville, Iowa) |
| ABSTRACT | The invention includes systems having a cover attached to a frame, and a transmission unit with a rotational device connected to or part of the frame. The cover is mechanically connected to the at least one rotational device. A vibration dampening unit mechanically connected to the transmission unit such that translational movement (e.g. vertical movements) of the cover causes rotational movement of the rotational device. The rotational movement is, in turn, transmitted to the vibration dampening unit via the transmission unit. Preferably, the vibration dampening unit is a passive unit and also a resistance force modulated vibration dampening unit. The invention also includes methods for dampening vibrations on a load which includes converting translational movement of a load to rotational movement in a transmission unit, the transmission magnifies the displacement and speed of the rotational movement, and then transmitting the rotational movement to a vibration dampening unit, which dissipated the vibrational energy. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333464 |
| CURRENT CPC | Springs; Shock-absorbers; Means for Damping Vibration F16F 15/18 (20130101) Original (OR) Class F16F 2222/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372893 | Carter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jared A. Carter (Rochester, New York); Akash S. Patel (Burlington, Vermont); Cassandra R. Walinski (Scottsville, New York); James A. Roussie (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared A. Carter (Rochester, New York); Akash S. Patel (Burlington, Vermont); Cassandra R. Walinski (Scottsville, New York); James A. Roussie (Rochester, New York) |
| ABSTRACT | Provided are methods, devices, and kits for the isolation of extracellular vesicles using silicon nanomembranes. A method for EV isolation includes the steps of collecting a biofluid sample, contacting the biofluid sample with a pre-filtration membrane, thereby forming a first filtrate and a first retentate, optionally, washing the first retentate of the pre-filtration membrane, contacting the first filtrate from the pre-filtration membrane with a capture membrane, thereby forming a second filtrate and a second retentate, optionally, washing the second retentate, and eluting the second retentate from the capture membrane or lysing the second retentate to recover the contents. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/382505 |
| CURRENT CPC | Separation B01D 61/027 (20130101) B01D 61/147 (20130101) B01D 65/08 (20130101) B01D 71/02 (20130101) B01D 2317/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 1/4005 (20130101) Original (OR) Class G01N 2001/4016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372918 | Wright |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Curtis Wright (Oregon, Wisconsin) |
| ABSTRACT | A method for coherent multidimensional spectroscopy may comprise illuminating a location in a sample with a set of m coherent light pulses, each coherent light pulse having an initial frequency ωm and an initial wave vector {right arrow over (k)}m, wherein m≥2, to generate a coherent output signal having an initial frequency ωoutput=Σ±ωm and an initial wavevector wave vector {right arrow over (k)}output=Σ±{right arrow over (k)}m; scanning a first coherent light pulse of the set of m coherent light pulses across a set of i frequency values, wherein i≥2, the set of i frequency values including the first coherent light pulse having initial frequency ω1; scanning, simultaneously, a second coherent light pulse of the set of m coherent light pulses across a set of i correlated frequency values, the set of i correlated frequency values including the second coherent light pulse having initial frequency ω2, wherein each correlated frequency value is associated with a corresponding frequency value of the set of i frequency values as a correlated frequency grouping; and detecting the coherent output signal. Each correlated frequency value is selected so that the coherent output signal generated at each correlated frequency grouping equals the initial frequency ωoutput and the coherent output signal generated at each correlated frequency grouping equals the initial wavevector {right arrow over (k)}output. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/329454 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372927 | GOPINATH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juliet T. GOPINATH (Boulder, Colorado); Brendan M. HEFFERNAN (Boulder, Colorado); Robert NIEDERRITER (Los Angeles, California); Stephanie A. MEYER (Denver, Colorado); Diego RESTREPO (Littleton, Colorado); Emily A. GIBSON (Boulder, Colorado); Mark E. SIEMENS (Denver, Colorado) |
| ABSTRACT | Sub-diffraction limited fluorescent images using a fiber-based stimulated emission depletion (STED) microscope are reported. Both excitation and depletion beams are transported through polarization-maintaining fiber and a lateral resolution of 100 nm has been achieved. |
| FILED | Friday, March 01, 2019 |
| APPL NO | 16/976946 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Original (OR) Class G01N 2021/6484 (20130101) Optical Elements, Systems, or Apparatus G02B 3/0087 (20130101) G02B 21/0032 (20130101) G02B 21/0068 (20130101) G02B 21/0076 (20130101) G02B 27/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372994 | Metzger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE ROCKEFELLER UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jakob Metzger (New York, New York); Fred Etoc (New York, New York); Ali Brivanlou (New York, New York); Eric Siggia (New York, New York) |
| ABSTRACT | Systems and methods for identifying molecules that are biologically active against a disease, where the method can comprise culturing a first mammalian cell population under organoid formation conditions in the presence of a test molecule to obtain a first organoid, wherein the first mammalian cell population, when cultured under the organoid formation conditions in the absence of the test molecule, results in an organoid with a disease phenotype; imaging the first organoid following exposure to the test molecule; analyzing one or more images of the first organoid using a neural network that has been trained to assign a probability score of disease or non-disease ranging between 0% and 100%; assigning the first organoid a probability score ranging between 0% and 100%; wherein the test molecule is biologically active against the disease if the probability score of the first organoid is greater than a cutoff probability score of non-disease or lower than a cutoff probability score of disease. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282039 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 2503/02 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 33/5014 (20130101) G01N 33/5076 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00147 (20130101) G06K 9/6256 (20130101) G06K 9/6262 (20130101) G06K 2209/05 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2200/04 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) G06T 2207/30072 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373002 | Gopinath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); UNIVERSITY OF BRITISH COLUMBIA (Vancouver, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashwin Gopinath (Cambridge, Massachusetts); Christopher Thachuk (Seattle, Washington); David G. Kirkpatrick (Vancouver, Canada); Paul W. Rothemund (Pasadena, California) |
| ABSTRACT | According to one embodiment of the present invention, a structure includes: a substrate having a patterned surface of one or more binding sites; and a molecular shape made by a polynucleotide platform having a shape corresponding to a shape of a binding site of the one or more binding sites, the molecular shape being bound to one of the one or more binding sites. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/396477 |
| CURRENT CPC | Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 50/18 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6445 (20130101) G01N 33/548 (20130101) Original (OR) Class G01N 33/54373 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373009 | Neogi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (Denton, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arup Neogi (Denton, Texas); Eric Ashalley (Cape Coast, Ghana) |
| ABSTRACT | A chiral metamaterial absorber modeled after the yin-yang symbol comprising: a top yin-yang shaped Au nanoparticles (YNPs); a PMMA layer; an Au backreflector; and a bottom glass layer. In alternative embodiments, provided are devices acting as sensors for detecting a nucleotide such as a cDNA and/or a protein such as a protein from a pathogen such as a bacteria or a virus, wherein the cDNA or protein can be derived from a Coronavirus, for example, a SARS CoV-2 or COVID-19 virus. In alternative embodiments, devices acting as sensors as provided herein can also be used to detect any protein for diagnostic or therapeutic purposes, wherein the protein can be derived from a blood or plasma sample, or a tissue sample, for example, a biopsy, from an individual in need thereof, for example, a human or an animal. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/334171 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) G01N 33/54373 (20130101) Original (OR) Class G01N 33/56983 (20130101) G01N 2201/0636 (20130101) G01N 2333/165 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373037 | Demirci et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL (Boston, Massachusetts); BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); BETH ISRAEL DEACONESS MEDICAL CENTER (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Utkan Demirci (Stanford, California); Ionita Ghiran (Boston, Massachusetts); Savas Tasoglu (Storrs, Connecticut); Ronald W. Davis (Palo Alto, California); Lars Steinmetz (Palo Alto, California); Naside Gozde Durmus (Palo Alto, California); Huseyin Cumhur Tekin (Palo Alto, California) |
| ABSTRACT | Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/169765 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0656 (20130101) G01N 15/1031 (20130101) G01N 27/76 (20130101) G01N 33/80 (20130101) Original (OR) Class G01N 33/487 (20130101) G01N 33/491 (20130101) G01N 33/574 (20130101) G01N 2015/0053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373311 | HILLMAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Elizabeth M.C. HILLMAN (New York, New York) |
| ABSTRACT | A pulsed beam of NIR excitation light is projected into a sample at an oblique angle and scanned by a scanning element through a volume in the sample. 2-photon excitation excites fluorescence within the sample. The fluorescence is imaged onto an intermediate image plane that remains stationary regardless of the orientation of the scanning element. The image is captured by a linear array of light detecting elements or a linear portion of a rectangular array. At any given position of the scanning element, the linear array (or portion) images all depths simultaneously. A plurality of images are captured for each of a plurality of different orientations of the scanning element. The orientation of the scanning element is controlled to move in a two dimensional pattern, which causes the beam of excitation light to sweep out a three dimensional volume within the sample. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/341870 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 2201/0675 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) G02B 21/0048 (20130101) G02B 21/0076 (20130101) Original (OR) Class G02B 21/367 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373663 | MATUSIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wojciech MATUSIK (Lexington, Massachusetts); Daniela L. RUS (Weston, Massachusetts); Andrew SPIELBERG (Cambridge, Massachusetts); Josephine Anna Eleanor HUGHES (Cambridge, Massachusetts); Gloria CHANG (Houston, Texas); Mark CHOUNLAKONE (Elgin, Illinois) |
| ABSTRACT | A wearable article comprising a knitted fabric formed in the shape of a glove. A force sensing element coupled to the fabric, the force sensing element comprising a resistive sensing system and a fluidic sensing system comprising one or more soft tubes coupled to a surface of the wearable glove wherein the resistive and fluid sensing systems correspond to first and second different sensor modalities which are physically decoupled. Control circuitry is coupled to receive signals from both the resistive sensing system and the fluidic sensing system and to combine resistive and fluidic sensing system signals provided thereto to perform at least one of: pose estimation, environment sensing, human state sensing, and static and dynamic task identification. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/214106 |
| CURRENT CPC | Woven Fabrics; Methods of Weaving; Looms D03D 1/0088 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2401/16 (20130101) D10B 2401/18 (20130101) Electric Digital Data Processing G06F 3/014 (20130101) Original (OR) Class G06F 3/016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374071 | Annapareddy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Narasimha Reddy Annapareddy (College Station, Texas); Chih-Chieh Chou (San Jose, California); Chandrahas Tirumulasetty (Bryan, Texas); Paul Gratz (College Station, Texas); Ayman Abouelwafa (Folsom, California) |
| ABSTRACT | Methods, systems, and computer readable media for performing page fault handling are disclosed. According to one method, the method includes: after a translation lookaside buffer (TLB) miss associated with a virtual memory page occurs, identifying, in a page table, a page table entry (PTE) associated with the virtual memory page; determining, using a first indicator in the PTE, that the virtual memory page is not present in a main memory; determining, using a second indicator in the PTE, that the virtual memory page is associated with a valid memory address and that the virtual memory page is capable of using pre-allocated pages; obtaining, from a pre-allocation table, a page frame number associated with a pre-allocated page; and updating the PTE to indicate the page frame number. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335936 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0223 (20130101) G06F 12/1027 (20130101) Original (OR) Class G06F 2212/657 (20130101) G06F 2212/684 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374152 | Kougkas et al. |
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| FUNDED BY |
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| APPLICANT(S) | Anthony Kougkas (Chicago, Illinois); Hariharan Devarajan (Chicago, Illinois); Xian-He Sun (Darien, Illinois) |
| ASSIGNEE(S) | ILLINOIS INSTITUTE OF TECHNOLOGY (Chicago, Illinois) |
| INVENTOR(S) | Anthony Kougkas (Chicago, Illinois); Hariharan Devarajan (Chicago, Illinois); Xian-He Sun (Darien, Illinois) |
| ABSTRACT | A system and method for executing input/output (I/O) tasks for clients in a distributed computing system. One or more I/O requests made by a client are received. The operation instructions for the request data in the I/O requests are separated from the request data. A data representation called data label (or label) is created for executing operation instructions of the I/O requests. A data label corresponds to each of the I/O request and includes a unique identifier, information to the source and/or destination for the request data, and an operation instruction separated from the request data. The data label is pushed into a distributed label queue and is dispatched to an individual worker node according to a scheduling policy. The worker node executes the I/O tasks by executing the dispatched data label. The system and method can execute I/O tasks independently and decoupled from the client applications. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336887 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/505 (20130101) G06F 9/4881 (20130101) G06F 9/5038 (20130101) G06F 16/254 (20190101) Original (OR) Class G06F 16/2471 (20190101) G06F 16/24573 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374503 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nam Sung Kim (Champaign, Illinois); Youjie Li (Changsha, China PRC); Alexander Gerhard Schwing (Champaign, Illinois) |
| ABSTRACT | A distributed network includes a first group of computing devices. Each computing device is to be coupled to two neighbor computing devices of the first group of computing device and is to: (i) aggregate gradient values received from a first neighbor computing device with local gradient values to generate a partial aggregate of gradient values that are to train a neural network model; (ii) transfer the partial aggregate of gradient values to a second neighbor computing device; and repeat (i) and (ii) until a first aggregate of gradient values from the first group of computing devices is buffered at a first computing device of the first group of computing devices. The first computing device is to transfer the first aggregate of gradient values to a second group of computing devices of the distributed network for further aggregation. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/284418 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/10 (20130101) G06N 3/0454 (20130101) Original (OR) Class Coding; Decoding; Code Conversion in General H03M 7/702 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374953 | Asiedu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mercy Asiedu (Durham, North Carolina); Nirmala Ramanujam (Durham, North Carolina); Guillermo Sapiro (Durham, North Carolina) |
| ABSTRACT | A method for automated detection of cervical pre-cancer includes: providing at least one cervigram; pre-processing the at least one cervigram; extracting features from the at least one pre-processed cervigram; and classifying the at least one cervigram as negative or positive for cervical pre-cancer based on the extracted features. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282093 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/136 (20170101) G06T 7/168 (20170101) G06T 2207/20024 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20132 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375480 | Mahon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bradford Mahon (Pittsburgh, Pennsylvania); Keith Parkins (Rochester, New York); Max Sims (Rochester, New York); Benjamin Chernoff (Pittsburgh, Pennsylvania); Hugo Angulo-Orquera (Pittsburgh, Pennsylvania) |
| ABSTRACT | A system for outputting a visual representation of a brain of a patient is configured to receive sensor data representing a behavior of a region of the brain of the patient. The system retrieves mapping data that maps a prediction value to the region. The prediction value is indicative of an effect on a behavior of the patient responsive to a treatment of the region, the mapping data being indexed to a patient identifier. The system receives, responsive to an application of a stimulation to the region, sensor data representing behavior of the region. The system executes a model that updates, based on the sensor data, the prediction value for the region. The system updates, responsive to executing the model, the mapping data by including the updated prediction value in the mapping data. The system outputs a visual representation of the updated mapping data comprising the updated prediction value. |
| FILED | Monday, December 02, 2019 |
| APPL NO | 17/272603 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/055 (20130101) A61B 5/0077 (20130101) A61B 5/372 (20210101) A61B 5/4803 (20130101) A61B 34/10 (20160201) A61B 2034/105 (20160201) A61B 2034/107 (20160201) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 15/00 (20180101) G16H 20/30 (20180101) G16H 20/40 (20180101) G16H 30/20 (20180101) G16H 30/40 (20180101) G16H 40/67 (20180101) G16H 50/20 (20180101) G16H 50/70 (20180101) Original (OR) Class Pictorial Communication, e.g Television H04N 5/91 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375574 | Williams |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Williams (Phoenix, Arizona) |
| ABSTRACT | A duoplasmatron ion source with a partially ferromagnetic anode can be used in multiple applications, including the production of negative ions for secondary ion mass spectrometers and particle accelerators. A partially ferromagnetic anode, which may be embodied in a partially ferromagnetic anode insert, includes a ferromagnetic and non-ferromagnetic portions joined together at a juncture, with an ion extraction aperture defined in the ferromagnetic portion and the juncture being laterally offset from the aperture. An asymmetric magnetic field produced by the partially ferromagnetic region facilitates extraction of charged ions from the central, most intense region of a source plasma in the duoplasmatron ion source. A ferromagnetic conical portion of the anode defines the ion extraction aperture in order to maximize the magnetic field in the vicinity of this aperture. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 16/972384 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 9/14 (20130101) H01J 27/10 (20130101) Original (OR) Class H01J 49/123 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376568 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chiao-Yu Cheng (State College, Pennsylvania); Noel C. Giebink (State College, Pennsylvania) |
| ABSTRACT | A method of generating a light-matter hybrid species of charged polaritons at room temperature includes providing an organic semiconductor microcavity being a doped organic semiconductor sandwiched in a microcavity capable of generating an optical resonance and coupling light to the polaron optical transition in the organic semiconductor microcavity thereby forming polaron-polaritons. The doped organic semiconductor may be a hole/electron transport material having a polaron absorption coefficient exceeding 102 cm−1 and capable of generating a polaron optical transition with a linewidth smaller than a predetermined threshold. The optical resonance of the microcavity has a resonance frequency matched with the polaron optical transition. |
| FILED | Wednesday, November 14, 2018 |
| APPL NO | 16/762541 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/002 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/36 (20130101) H01S 5/0422 (20130101) H01S 5/1042 (20130101) Original (OR) Class H01S 5/18369 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376612 | Barooah |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prabir Barooah (Gainesville, Florida) |
| ABSTRACT | Systems and methods are configured to managing and controlling an energy system comprising at least one primary energy load, at least one secondary energy load, and an energy storage subsystem configured to receive energy from an energy source and provide energy to the energy loads. In embodiments, a method is provided. The method includes receiving a first system state data object associated with a first timepoint, generating a second system state data object associated with a second timepoint, determining control commands for each of the at least one primary energy load, the at least one secondary energy load, and the energy storage subsystem based at least in part on evaluating the second system state data object in a constrained optimization model, and causing energy to be supplied at the second timepoint to the energy loads and/or the energy storage subsystem based at least in part on the control commands. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/328921 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/042 (20130101) G05B 13/048 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/381 (20130101) Original (OR) Class H02J 13/00002 (20200101) H02J 2203/20 (20200101) H02J 2300/24 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376721 | Gui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Handong Gui (Knoxville, Tennessee); Leon M. Tolbert (Knoxville, Tennessee) |
| ABSTRACT | An electronic circuit includes a charge pump circuit, which includes a drive power supply; a flying capacitor; and a pump capacitor that is coupled in parallel to the drive power supply and the flying capacitor in response to a first control signal being in first state and is configured to receive charge from the flying capacitor to boost a pump voltage across the pump capacitor to a value that exceeds a drive voltage provided by the drive power supply responsive to a transition of the first control signal from the first state to a second state. The electronic circuit further includes a gate drive circuit coupled to the charge pump circuit. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336684 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/071 (20210501) H02M 3/077 (20210501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376768 | Wilson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | Amy Charlene Wilson (Belton, Missouri) |
| ABSTRACT | An electrostatic energy harvester broadly comprises an electrical energy storage component, an electrical energy transfer stage, first and second variable capacitors, and a switching control module. The electrical energy transfer stage includes diode-connected transistors and dictates electrical energy transfer between the electrical energy storage component and the variable capacitors. The switching control module timely switches between the first and second variable capacitors according to a state machine. Subsequent electrical energy investments from the electrical energy storage component are less than an initial electrical energy investment due to remnant electrical energy remaining at the previously active one of the first and second variable capacitors from previous electrical energy harvesting. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 16/889874 |
| CURRENT CPC | Electric Machines Not Otherwise Provided for H02N 1/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376770 | Wilson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | Amy Charlene Wilson (Belton, Missouri) |
| ABSTRACT | An electrostatic energy harvester broadly comprises an electrical energy storage component, an electrical energy transfer stage, first and second variable capacitors, and a switching control module. The electrical energy transfer stage includes diode-connected transistors and dictates electrical energy transfer between the electrical energy storage component and the variable capacitors. The switching control module timely switches between the first and second variable capacitors according to a state machine. Subsequent electrical energy investments from the electrical energy storage component are less than an initial electrical energy investment due to remnant electrical energy remaining at the previously active one of the first and second variable capacitors from previous electrical energy harvesting. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 16/889890 |
| CURRENT CPC | Electric Machines Not Otherwise Provided for H02N 1/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376788 | Bowden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Stuart Bowden (Tempe, Arizona); Antony Aguilar (Scottsdale, Arizona) |
| ABSTRACT | A self-powered voltage ramp for photovoltaic module testing provides a robust circuit for the measurement of current-voltage curves. A resistor and capacitor form a timer circuit to control a gate of a power transistor and give a linear voltage sweep from a short circuit (e.g., zero volts) to an open circuit voltage VOC. The sweep rate can be varied by adjusting the resistor value. Additional enhancements prevent oscillations within the circuit, maintain a voltage of the power transistor within its design specifications, and allow for the measurement of single cell mini-modules. Additional circuitry can characterize the photovoltaic module based on the measurement data. Measurement accuracy is within 1% of a laboratory supply for measurements of maximum power, short circuit current, and open circuit voltage. |
| FILED | Tuesday, August 27, 2019 |
| APPL NO | 17/263361 |
| CURRENT CPC | Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 50/10 (20141201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376937 | Becnel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Becnel (Salt Lake City, Utah); Pierre-Emmanuel Gaillardon (Salt Lake City, Utah); Kerry Elizabeth Kelly (Salt Lake City, Utah) |
| ABSTRACT | A computer system for recursive calibration of a sensor network receives a first data communication from a first sensor node that is a neighbor to a calibrated sensor node. The computer system then updates a set of linear regressions between the first sensor node and a set of neighboring sensor nodes, which include the neighboring, calibrated sensor node. The computer system calibrates the first sensor node using an average of the set of linear regressions weighted by a correlation. When the first sensor node is calibrated, the computer system uses the calibrated first sensor node in calibration of a neighboring, uncalibrated sensor node. The computer system then gathers, at the first sensor node, a calibrated sensor reading. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 16/888270 |
| CURRENT CPC | Transmission H04B 17/11 (20150115) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) H04L 67/12 (20130101) H04L 67/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210377156 | Michael et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VMware, Inc. (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nithin Michael (San Francisco, California); Ao Tang (San Francisco, California); Victor de Souza Lima e Silva (San Francisco, California); Thiago Sousa Santos (San Francisco, California); Ning Wu (San Francisco, California); Archit Baweja (San Francisco, California); Ki Suh Lee (San Francisco, California); Yao Wang (San Francisco, California); Andrey Gushchin (San Francisco, California); Sakethnath Are (San Francisco, California) |
| ABSTRACT | A system comprising nodes coupled to a network including virtual links in an overlay network provisioned over an underlay network. The system includes a virtual machine (VM) provisioned at a node and coupled to the network. The VM is configured to receive feedback data of link conditions, and use the feedback data to dynamically determine and adapt an optimal route through the network. The VM is configured to control routing of traffic flows using the optimal route. The routing includes split routing of a traffic flow from the node via two or more of the virtual links. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240890 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/0864 (20130101) H04L 43/0876 (20130101) H04L 45/22 (20130101) Original (OR) Class H04L 45/24 (20130101) H04L 45/745 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210369809 | ZISCHKA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH) (Neuherberg, Germany); THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan); IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hans ZISCHKA (Munich, Germany); Josef LICHTMANNEGGER (Neuching, Germany); Alan Angelo DISPIRITO (Ames, Iowa); Jeremy David SEMRAU (Ann Arbor, Michigan) |
| ABSTRACT | The present invention relates to the field of (bio-)medicine, and more particularly to the treatment of copper-related diseases. Novel means and methods for depleting (excess) copper from organs and/or the circulation are provided. Agents with a high copper binding affinity and stabilized forms thereof are provided, as well as a novel treatment regimen. The means and methods of the present invention are particularly useful for treatment of Wilson Disease, but also for treatment of other conditions. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/221675 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/164 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370230 | Wright et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Allen Wright (Gilbert, Arizona); Klaus Lackner (Paradise Valley, Arizona) |
| ABSTRACT | A method for enhancing a sorbent membrane for carbon dioxide capture is disclosed. The method includes applying a layer of a hydrophobic material to at least one surface of the sorbent membrane. The hydrophobic material may be one of a polysioxane, a silicone compound, and a fluoroacrylic copolymer. The sorbent membrane may be an anionic exchange membrane, and may have a quaternary ammonium functional group. The layer of hydrophobic material reduces the amount of water used in the carbon dioxide capture process, and relaxes the water quality constraints. |
| FILED | Monday, October 28, 2019 |
| APPL NO | 17/287982 |
| CURRENT CPC | Separation B01D 53/228 (20130101) Original (OR) Class B01D 2257/504 (20130101) B01D 2323/04 (20130101) B01D 2325/20 (20130101) B01D 2325/38 (20130101) B01D 2325/42 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/285 (20130101) B01J 20/328 (20130101) B01J 20/3272 (20130101) B01J 20/3276 (20130101) B01J 20/3285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370584 | Baerga Santiago et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Eaton Intelligent Power Limited (Dublin 4, Ireland) |
| ASSIGNEE(S) | Eaton Intelligent Power Limited (Dublin 4, Ireland) |
| INVENTOR(S) | Jeremy M. Baerga Santiago (Southfield, Michigan); Namrata Salunke (Farmington Hills, Michigan); Javed Mapkar (Northville, Michigan) |
| ABSTRACT | A method of manufacturing a three-dimensional lens comprises inputting a lens template into a controller, depositing a first layer of lens material onto a work surface according to the lens Template, and successively depositing additional filamentous layers of the lens material onto the first layer. The deposition of layers of lens material is done according to the lens template in order to build the three-dimensional lens with a particular transmission scattering profile for transmitted light. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307423 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/40 (20170801) B29C 64/118 (20170801) Original (OR) Class B29C 64/188 (20170801) B29C 64/393 (20170801) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00432 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370606 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seokpum Kim (Oak Ridge, Tennessee); John C. Bowers (Harrisonburg, Virginia); Kenneth Stephenson (Knoxville, Tennessee); Vlastimil Kunc (Oak Ridge, Tennessee); Ahmed Arabi Hassen (Oak Ridge, Tennessee); Lonnie J. Love (Oak Ridge, Tennessee); Gregory D. Dreifus (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for generating graded lattice structures that can be used as infill for additively manufactured articles. Tailored sectioning and field-based smoothing are modified polygon, e.g., circle, packing algorithms that adjust the size of the circles based on physical field data to adapt the infill generation process to a field expected to be experienced by the article. Molecular dynamically generated lattice infill is based on force balancing a node distribution instead of a circle packing. Field data can be utilized to adjust the spacing of the node distribution according to a force balance equilibrium model that accounts for the field expected to be experienced by the article being additively manufactured. The resultant non-uniform honeycomb structures from tailored sectioning, field-based smoothing, and force-balancing robustly and efficiently address the connection issues with traditional non-uniform lattice structures. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333619 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/386 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210370969 | HEGDE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GM GLOBAL TECHNOLOGY OPERATIONS LLC (Detroit, Michigan); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bharatkumar HEGDE (Bloomfield Hills, Michigan); Junfeng ZHAO (Troy, Michigan); Lung En JAN (Pittsburgh, Pennsylvania); Chen-fang CHANG (Bloomfield Hills, Michigan); Ragunathan RAJKUMAR (Monroeville, Pennsylvania) |
| ABSTRACT | A control system of a vehicle includes: a target speed module configured to, using a parametric driver model and based on first driver parameters, second driver parameters, and vehicle parameters, determine a target vehicle speed trajectory for a future predetermined period; a driver parameters module configured to determine the first driver parameters based on conditions within a predetermined distance in front of the vehicle; and a control module configured to adjust at least one actuator of the vehicle based on the target vehicle speed trajectory and a present vehicle speed. |
| FILED | Wednesday, May 27, 2020 |
| APPL NO | 16/884198 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 10/06 (20130101) B60W 30/162 (20130101) B60W 40/08 (20130101) B60W 40/13 (20130101) B60W 40/072 (20130101) B60W 40/105 (20130101) B60W 60/001 (20200201) Original (OR) Class B60W 2420/40 (20130101) B60W 2510/1005 (20130101) B60W 2552/20 (20200201) B60W 2554/80 (20200201) B60W 2555/60 (20200201) B60W 2556/45 (20200201) Controlling Combustion Engines F02D 9/08 (20130101) F02D 41/30 (20130101) Ignition, Other Than Compression Ignition, for Internal-combustion Engines; Testing of Ignition Timing in Compression-ignition Engines F02P 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371291 | FLAHERTY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | David William FLAHERTY (Urbana, Illinois); Daniel Bregante (Urbana, Illinois) |
| ABSTRACT | A method for the synthesis of siliceous or heteroatom-substituted MFI zeolites (M-MFI; M=Si, Ti, Nb, or Ta) with tunable densities of SiOH that depend simply on the ratio of hydrofluoric acid (HF) to structure-directing agent (SDA; tetrapropylammonium hydroxide) used within the synthesis gel. The equilibrated ion exchange between OH− and F− ions forms tetrapropylammonium fluoride in situ, which does not lead to the formation of SiOH defects within M-MFI. Comparisons of infrared spectra from 15 distinct M-MFI materials show that the densities of SiOH groups within M-MFI decrease linearly with the ratio of HF:SDA, independent of the identity of the heteroatom within the framework. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/326012 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 39/46 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371387 | Bara et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason E. Bara (Tuscaloosa, Alabama); Kathryn E. O'Harra (Tuscaloosa, Alabama) |
| ABSTRACT | Systems comprising a composition where an imidazole is tethered to an amine and a solvent are described herein. Methods of their preparation and use are also described herein. The methods of using the systems include the reduction of volatile compounds from gas streams and a liquid stream. |
| FILED | Thursday, April 01, 2021 |
| APPL NO | 17/220206 |
| CURRENT CPC | Separation B01D 53/1456 (20130101) B01D 53/1493 (20130101) B01D 2252/20473 (20130101) Heterocyclic Compounds C07D 233/64 (20130101) Original (OR) Class Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 3/104 (20130101) C10L 2290/542 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371575 | Jones et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brad Howard Jones (Albuquerque, New Mexico); Chad Lynn Staiger (Albuquerque, New Mexico) |
| ABSTRACT | Novel polymers are depolymerizable by metathesis of a cleavable unit. As an example, a series of linear and crosslinked polyurethanes were prepared that can be selectively depolymerized under mild conditions. Two unique polyols were synthesized bearing unsaturated units in a configuration designed to favor ring-closing metathesis to five- and six-membered cycloalkenes. These polyols were co-polymerized with toluene diisocyanate to generate linear polyurethanes and trifunctional hexamethylene- and diphenylmethane-based isocyanates to generate crosslinked polyurethanes. The polyol design is such that the ring-closing metathesis reaction cleaves the backbone of the polymer chain. Upon exposure to dilute solutions of Grubbs' catalyst under ambient conditions, the polyurethanes were rapidly depolymerized to low molecular weight, soluble products bearing vinyl and cycloalkene functionalities. These functionalities enabled further re-polymerization by traditional strategies for polymerization of double bonds. This general approach can be expanded to develop a range of chemically recyclable condensation polymers that are readily depolymerized by orthogonal metathesis chemistry. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244012 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 6/04 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/3206 (20130101) Original (OR) Class C08G 18/3212 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/10 (20130101) C08J 2375/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371617 | Sutton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| INVENTOR(S) | Andrew D. Sutton (Los Alamos, New Mexico); Christopher David Roland (Los Alamos, New Mexico); Cameron M. Moore (Los Alamos, New Mexico) |
| ABSTRACT | Disclosed herein are embodiments of a method for making recyclable polymers and a method for decomposing the polymers back to the monomers which can then be reused. The polymer are stable to aqueous and/or acid conditions and may have a formula II The method to decompose the polymer back to the monomers may comprise heating the polymer in a protic organic solvent. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/321849 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 64/0208 (20130101) C08G 64/403 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/24 (20130101) Original (OR) Class C08J 2367/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371790 | MACQUEEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luke A. MACQUEEN (Cambridge, Massachusetts); Kevin Kit PARKER (Cambridge, Massachusetts); Josue A. GOSS (Cambridge, Massachusetts); Christophe CHANTRE (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods are provided including a housing configured to receive and engage a hollow tissue structure within a fluid chamber of the housing. A first pair of flow channels and a second pair of flow channels of the housing are fluidly coupled to the fluid chamber. The housing fluidly couples the first pair of flow channels and fluidly couples the second pair of flow channels via a second flow path such that a change in a fluid pressure differential between a first fluid in the first flow path and a second fluid in the second flow path deflects at least a portion of the hollow tissue structure causing a change in flow of the first fluid through the first pair of flow channels or a change in flow of the second fluid through the second pair of flow channels. |
| FILED | Tuesday, February 05, 2019 |
| APPL NO | 16/968178 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/20 (20130101) C12M 25/14 (20130101) Original (OR) Class C12M 29/00 (20130101) C12M 41/44 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0652 (20130101) C12N 5/0697 (20130101) C12N 2503/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372001 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Wang (Acton, Massachusetts); Xiaotu MA (Worcester, Massachusetts); Eric Gratz (Worcester, Massachusetts); Jinzhao Fu (Worcester, Massachusetts); Panawan Vanaphuti (Worcester, Massachusetts) |
| ABSTRACT | A recycling and synthesis of charge material for secondary batteries generates single-crystal charge materials for producing batteries with greater charge cycle longevity. Charge material particles undergo a heating for fusing or enhancing grain boundaries between polycrystalline particles. The resulting, more well-defined grain boundaries are easily etched by a relatively weak mineral acid solution. The acid solution removes material at the grain boundaries to separate secondary particles into primary particles along the grain boundaries. The resulting single crystal (monocrystalline) charge material particles are washed and filtered, and typically re-sintered to accommodate any needed lithium (lithium carbonate), and result in a charge material with larger surface area, higher lithium diffusivity and lower cation ordering. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/330922 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 1/02 (20130101) Original (OR) Class C30B 1/12 (20130101) C30B 29/22 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/54 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210372014 — ENVIRONMENTALLY RESPONSIVE BI-COMPONENT META FIBER TEXTILES AND METHODS OF MANUFACTURE
| US 20210372014 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | YuHuang WANG (LAUREL, Maryland); Zhiwei PENG (LAUREL, Maryland); Beibei XU (SEATTLE, Washington); Behnam POURDEYHIMI (CARY, North Carolina); Abhay JOIJODE (RALEIGH, North Carolina) |
| ABSTRACT | A bimorph meta fiber is formed through spinning of two antagonistic polymer melts, one of which contains pre-compounded optical nanostructures, into an eccentric sheath-core configuration or a side-by-side key-lock configuration. The bimorph meta fiber is capable of an adaptive regulation of the infrared radiation responsive to humidity level deviation from a comfort zone or perspiration level of the wearer of the garment fabricated from the meta fibers. The bimorph meta fibers are humidity/heat trained to attain dynamical environmentally responsive behavior to maintain the humidity/thermal comfort zone at various the humidity level fluctuations. |
| FILED | Tuesday, April 30, 2019 |
| APPL NO | 17/286120 |
| CURRENT CPC | Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/10 (20130101) D01F 8/12 (20130101) D01F 8/14 (20130101) Woven Fabrics; Methods of Weaving; Looms D03D 15/30 (20210101) D03D 15/283 (20210101) D03D 15/292 (20210101) Original (OR) Class D03D 15/527 (20210101) D03D 15/547 (20210101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2101/122 (20130101) D10B 2331/02 (20130101) D10B 2331/04 (20130101) D10B 2401/022 (20130101) D10B 2501/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372324 | Slabaugh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carson Daniel Slabaugh (West Lafayette, Indiana); Rohan Madhav Gejji (West Lafayette, Indiana); Kyle S. Schwinn (West Lafayette, Indiana); Stephen D. Heister (West Lafayette, Indiana); Swanand V. Sardeshmukh (West Lafayette, Indiana) |
| ABSTRACT | A detonation engine includes at least one chamber wall and a first detonation chamber defined by the at least one chamber wall, the first detonation chamber having a first end and a second end. The first detonation chamber is linear, curved, or includes a plurality of detonation chamber segments that are linear and/or curved, and the detonation engine is configured such that detonation repeatedly propagates from the first end of the first detonation chamber to the second end of the first detonation chamber. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213740 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 5/10 (20130101) Original (OR) Class Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof F02M 57/00 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372346 | Anders et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Caterpillar Inc. (Peoria, Illinois); UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | Caterpillar Inc. (Peoria, Illinois); UChicago Argonne, LLC (Chicago, Illinois) |
| INVENTOR(S) | Jonathan Wiliam Anders (Peoria, Illinois); Naga Krishna Chaitanya Kavuri (Peoria, Illinois); Bobby John (Peoria, Illinois); Hyderuddin Mohammad (Peoria, Illinois); Chao Xu (Westmont, Illinois); Prithwish Kudu (Pimpri, India) |
| ABSTRACT | An internal combustion engine system includes an engine housing having a combustion cylinder, and a piston movable within the combustion cylinder to increase a pressure therein to an autoignition threshold for injected fuel. The piston includes a piston crown having a combustion face forming a combustion bowl, and varied in profile to form jet-jet interaction limiters at locations offset from fuel spray jet paths from a fuel injector. The jet-jet interaction limiters include a bowl component and a step component protruding, respectively, within the combustion bowl and a step located transitioning between the combustion bowl and a circumferential rim of the piston. Limiting jet-jet interaction limits soot production in exhaust produced by the engine. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 16/889958 |
| CURRENT CPC | Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 3/20 (20130101) F02F 3/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372668 | BUSCHECK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. BUSCHECK (Pleasanton, California); Ravindra Shrikrishna UPADHYE (Pleasanton, California) |
| ABSTRACT | The present disclosure relates to a system for storing and time shifting at least one of excess electrical power from an electrical power grid, excess electrical power from the power plant itself, or heat from a heat generating source, in the form of pressure and heat, for future use in assisting with a production of electricity. An oxy-combustion furnace is powered by a combustible fuel source, plus excess electricity, during a charge operation to heat a reservoir system containing a quantity of a thermal storage medium. During a discharge operation, a discharge subsystem has a heat exchanger which receives heated CO2 from the reservoir system and uses this to heat a quantity of high-pressure, supercritical CO2 (sCO2) to form very-high-temperature, high-pressure sCO2 at a first output thereof. The very-high-temperature, high-pressure sCO2 is used to drive a Brayton-cycle turbine, which generates electricity at a first output thereof for transmission to a power grid. The Brayton-cycle turbine also outputs a quantity of sCO2 which is reduced in temperature and pressure to a heat recuperator subsystem. The heat recuperator subsystem circulates the sCO2 and re-heats and re-pressurizes the sCO2 before feeding it back to the heat exchanger to be even further reheated, and then output to the Brayton-cycle turbine as a new quantity of very-high-temperature, high-pressure sCO2, to assist in powering the Brayton-cycle turbine. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397515 |
| CURRENT CPC | Steam Engine Plants; Steam Accumulators; Engine Plants Not Otherwise Provided For; Engines Using Special Working Fluids or Cycles F01K 27/00 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/04 (20130101) F03G 7/06 (20130101) Geothermal Collectors; Geothermal Systems F24T 10/20 (20180501) Original (OR) Class Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/0052 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 6/34 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 20/16 (20130101) Y02E 60/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372898 | Nation et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brendan L. Nation (Albuquerque, New Mexico); Michael T. Dugger (Tijeras, New Mexico); John Curry (Albuquerque, New Mexico) |
| ABSTRACT | The present invention relates, in part, to systems for characterizing force (e.g., friction, wear, and/or torque). In one embodiment, the system allows for wear testing of samples in a high throughput manner. In another embodiment, the system allows for torque sensing in a non-contact manner. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399954 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 3/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/02 (20130101) G01N 3/56 (20130101) Original (OR) Class G01N 21/27 (20130101) G01N 2201/08 (20130101) G01N 2201/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372957 | Blue et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas E. Blue (Columbus, Ohio); Anthony Birri (Columbus, Ohio); Christian M. Petrie (Knoxville, Tennessee) |
| ABSTRACT | An optical fiber-based gamma-ray calorimeter (OFBGC) sensor array which uses a thermal mass with a low thermal conductivity is provided. Advantages of the OFBGC sensor array include: 1) the number of sensors in the OFBGC sensor array is adjustable and limited only by the spatial resolution of the OFBGC sensors, within the OFBGC sensor array, and 2) the OFBGC sensor design is simpler to build than a conventional optical fiber-based gamma thermometer (OFBGT) sensor array. One purpose of the OFBGC is to determine the power distribution in nuclear reactors. |
| FILED | Friday, March 26, 2021 |
| APPL NO | 17/213432 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/4813 (20130101) Original (OR) Class Nuclear Reactors G21C 17/112 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373111 | HUI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaonan HUI (Ithaca, New York); Edwin C. KAN (Ithaca, New York) |
| ABSTRACT | A radio-frequency method for range finding includes modulating a reference signal having an intermediate frequency to a downlink signal having a carrier frequency using a clock signal. The downlink signal is transmitted to a tag using a transceiver. An uplink signal backscattered from the tag is received and demodulated using the clock signal. The uplink signal has a frequency that is a harmonic of the carrier frequency. A distance between the tag and the transceiver is calculated based on a phase of the demodulated uplink signal. A system for range finding includes a transceiver and a processor. The transceiver modulates a reference signal to a downlink signal and transmits the downlink signal. The transceiver receives and demodulates an uplink signal. The processor is configured to receive the demodulated uplink signal and calculate a distance between the tag and the transceiver using a phase of the demodulated uplink signal. |
| FILED | Thursday, October 31, 2019 |
| APPL NO | 17/289702 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 1/022 (20130101) G01S 1/306 (20130101) Original (OR) Class G01S 1/0428 (20190801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373212 | Burcklen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Catherine Burcklen (Oakland, California); Tommaso Pardini (Oakland, California); Regina Soufli (Berkeley, California) |
| ABSTRACT | A multilayer film structure, and method of making such a multilayer film structure, which includes a first layer consisting essentially of a first material and a second layer consisting essentially of a second material. In embodiments, the multilayer film structure includes a plurality of first layers alternating with a plurality of second layers. The layers are constructed by applying a N2-based reactive sputtering methodology so that the layers maintain a largely amorphous microstructure and a stable and high reflectivity upon annealing at temperatures up to 800° C. for 1 hour. |
| FILED | Tuesday, May 26, 2020 |
| APPL NO | 16/883787 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/0652 (20130101) Optical Elements, Systems, or Apparatus G02B 5/285 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373229 | Kiani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Leily S. Kiani (Napa, California); Jay W. Dawson (Livermore, California); Derrek R. Drachenberg (Livermore, California); Michael J. Messerly (Danville, California); Paul H. Pax (Livermore, California) |
| ABSTRACT | A non-radial array of microstructure elements provides enhanced wavelength selective filtering. The elements are arranged along a line that does not intersect the center of the core. In this configuration, the first coupling element in an array that is nearest to the core is a non-integer array unit spacing from the main waveguide where the array unit spacing is defined as the flat to flat distance of a hexagonal cell. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 16/887313 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/02052 (20130101) G02B 6/02371 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373362 | Okawachi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoshitomo Okawachi (River Edge, New Jersey); Jae Jang (New York, New York); Xingchen Ji (New York, New York); Michal Lipson (New York, New York); Alexander L. Gaeta (New York, New York) |
| ABSTRACT | Optical frequency combs and related methods, devices, and systems are described. An example device can comprise a waveguide configured to optically couple to an optical source and at least one optical resonator optically coupled to the waveguide. The one or more of the at least one optical resonator can be tuned such that an optical frequency comb is generated based on mode interaction between two different modes of the at least one optical resonator. The device can comprise an output coupled to the waveguide and configured to output the optical frequency comb. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400813 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/015 (20130101) Original (OR) Class G02F 1/212 (20210101) G02F 2203/15 (20130101) G02F 2203/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373552 | Bhuyan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho); North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arupjyoti Bhuyan (Idaho Falls, Idaho); Ismail Guvenc (Cary, North Carolina); Huaiyu Dai (Raleigh, North Carolina) |
| ABSTRACT | Systems, devices, and methods are described for controlling, and communicating with, unmanned aerial vehicles (UAVs) over a millimeter wave (mmWave) communication network established between a base station and the UAVs. A communication system may include one or more unmanned aerial vehicles (UAVs). The communication system may further include one or more base stations including millimeter wave (mmWave) antennas configured to generate control signals to the one or more UAVs over an mmWave communication network. |
| FILED | Tuesday, November 05, 2019 |
| APPL NO | 17/309127 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/146 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0022 (20130101) Original (OR) Class G05D 1/0027 (20130101) Wireless Communication Networks H04W 4/40 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373975 | DUTU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ADVANCED MICRO DEVICES, INC. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandru DUTU (Bellevue, Washington); Matthew David SINCLAIR (Bellevue, Washington); Bradford BECKMANN (Bellevue, Washington); David A. WOOD (Austin, Texas) |
| ABSTRACT | A processing system monitors and synchronizes parallel execution of workgroups (WGs). One or more of the WGs perform (e.g., periodically or in response to a trigger such as an indication of oversubscription) a waiting atomic instruction. In response to a comparison between an atomic value produced as a result of the waiting atomic instruction and an expected value, WGs that fail to produce a correct atomic value are identified as being in a waiting state (e.g., waiting for a synchronization variable). Execution of WGs in the waiting state is prevented (e.g., by a context switch) until corresponding synchronization variables are released. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/029935 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/461 (20130101) G06F 9/522 (20130101) Original (OR) Class G06F 9/3005 (20130101) G06F 11/3024 (20130101) G06F 11/3476 (20130101) G06F 11/3495 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374593 | Niroula et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IONQ, INC. (College Park, Maryland); University of Maryland (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pradeep Niroula (College Park, Maryland); Yunseong Nam (North Bethesda, Maryland) |
| ABSTRACT | A method of determining a pattern in a sequence of bits using a quantum computing system includes setting a first register of a quantum processor in a superposition of a plurality of string index states, encoding a bit string in a second register of the quantum processor, encoding a bit pattern in a third register of the quantum processor, circularly shifting qubits of the second register conditioned on the first register, amplifying an amplitude of a state combined with the first register in which the circularly shifted qubits of the second register matches qubits of the third register, measuring an amplitude of the first register and determining a string index state of the plurality of string index states associated with the amplified state, and outputting, by use of a classical computer, a string index associated with the first register in the measured state. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313671 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/30032 (20130101) G06F 9/30101 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374968 | Martinez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carianne Martinez (Albuquerque, New Mexico); Kevin Matthew Potter (Albuquerque, New Mexico); Emily Donahue (Albuquerque, New Mexico); Matthew David Smith (Albuquerque, New Mexico); Charles J. Snider (Albuquerque, New Mexico); John P. Korbin (Albuquerque, New Mexico); Scott Alan Roberts (Albuquerque, New Mexico); Lincoln Collins (Albuquerque, New Mexico) |
| ABSTRACT | A method for digital image segmentation is provided. The method comprises training a neural network for image segmentation with a labeled training dataset from a first domain, wherein a subset of nodes in the neural net are dropped out during training. The neural network receives image data from a second, different domain. A vector of N values that sum to 1 is calculated for each image element, wherein each value represents an image segmentation class. A label is assigned to each image element according to the class with the highest value in the vector. Multiple inferences are performed with active dropout layers for each image element, and an uncertainty value is generated for each image element. The label of any image element with an uncertainty value above a predefined threshold is replaced with a new label corresponding to the class with the next highest value. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 16/887311 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/18 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/628 (20130101) G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) G06N 5/046 (20130101) Image Data Processing or Generation, in General G06T 7/174 (20170101) Original (OR) Class G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375511 | Landa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Landa (Livermore, California); Per Soderlind (Oakland, California); Emily Moore (Livermore, California); Aurelien Perron (Pleasanton, California) |
| ABSTRACT | In accordance with one aspect of the presently disclosed inventive concepts, a magnet includes a material having a chemical formula: YFe3(Ni1-xCox)2, where x is greater than 0 and x is less than 1. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 17/398905 |
| CURRENT CPC | Alloys C22C 30/00 (20130101) C22C 2202/02 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/047 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375536 | Beddingfield et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina); UNITED STATES DEPARTMENT OF ENERGY (Washington, District of Columbia) |
| ASSIGNEE(S) | UNITED STATES DEPARTMENT OF ENERGY (WASHINGTON, District of Columbia) |
| INVENTOR(S) | Richard B. Beddingfield (Raleigh, North Carolina); Subhashish Bhattacharya (Raleigh, North Carolina); Paul Richard Ohodnicki (Allison Park, Pennsylvania); Kevin Michael Byerly (Pittsburgh, Pennsylvania) |
| ABSTRACT | Various examples are provided related to mixed material magnetic cores, which can be utilized for shielding of eddy current induced excess losses. In one example, a magnetic core includes a ribbon core and leakage prevention or redirection shielding surrounding at least a portion of the ribbon core. The leakage prevention or redirection shielding can be positioned adjacent to the ribbon core and between the ribbon core and a magnetomotive force (MMF) source such as, e.g., a coil. The leakage prevention or redirection shielding extend beyond the ends of the MMF source and, in some implementations, can extend over the ends of the MMF source. In another example, a magnetic device can include a ribbon core, a MMF and leakage prevention or redirection shielding positioned between the MMF source and the ribbon core. |
| FILED | Tuesday, November 06, 2018 |
| APPL NO | 16/762072 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/25 (20130101) H01F 27/28 (20130101) H01F 27/346 (20130101) Original (OR) Class H01F 27/363 (20200801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376260 | Li |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Li (Tempe, Arizona) |
| ABSTRACT | A near-infrared organic light emitting device comprises a first electrode; a hole transporting layer in contact with the first electrode; a second electrode; an electron transporting layer in contact with the second electrode; and an emissive layer between the hole transporting layer and the electron transporting layer, the emissive layer comprising a near-infrared emitter and an emissive host. The emissive host transfers energy to the near-infrared emitter. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335182 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/0086 (20130101) C07F 15/0093 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/02 (20130101) C09K 11/06 (20130101) C09K 2211/185 (20130101) C09K 2211/1007 (20130101) C09K 2211/1014 (20130101) C09K 2211/1022 (20130101) C09K 2211/1029 (20130101) C09K 2211/1044 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0087 (20130101) Original (OR) Class H01L 51/5056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376310 | DASGUPTA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | NEIL P. DASGUPTA (ANN ARBOR, Michigan); KUAN-HUNG CHEN (ANN ARBOR, Michigan); ERIC KAZYAK (ANN ARBOR, Michigan) |
| ABSTRACT | A method of making an ionically conductive layer for an electrochemical device is disclosed. A film is coated on electrode material particles or post-calendered electrodes. This coating may be a lithium borate-carbonate film deposited by atomic layer deposition. One example method includes the steps of: (a) exposing a substrate including an electrode material to a lithium-containing precursor followed by an oxygen-containing precursor; and (b) exposing the substrate to a boron-containing precursor followed by the oxygen-containing precursor. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333485 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/45553 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/0404 (20130101) H01M 4/1391 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376327 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lu ZHANG (Lisle, Illinois); Zhangxing SHI (Westmont, Illinois); Andrew JANSEN (Bolingbrook, Illinois); Stephen TRASK (Batavia, Illinois) |
| ABSTRACT | A binder solution for manufacturing silicon-based anodes useful for lithium-ion electrochemical cells is described herein. The binder solution comprises a poly(carboxylic acid) binder dissolved in a mixed solvent system comprising an amide solvent of Formula I, as described herein, and a second solvent which can be water and/or an organic solvent. The binder preferably comprises poly(acrylic acid). The mixed solvent system comprises about 10 to about 99 vol % of the amide solvent of Formula I. The binder solution is utilized as a solvent for a slurry of silicon-containing particles for preparing a silicon-containing electrode. The slurries made with the mixed solvent systems have higher viscosity and are more stable than slurries containing the same concentrations of silicon particle, carbon particles, and binder in water as the sole solvent. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 16/886908 |
| CURRENT CPC | Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/02 (20130101) C08K 3/04 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) C09D 133/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/386 (20130101) H01M 4/0404 (20130101) H01M 4/0471 (20130101) H01M 4/622 (20130101) Original (OR) Class H01M 4/1395 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) H01M 2220/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376400 | Bhave et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramesh R. Bhave (Knoxville, Tennessee); Syed Z. Islam (Knoxville, Tennessee); Priyesh A. Wagh (Knoxville, Tennessee) |
| ABSTRACT | Single-stage and multi-stage systems and methods for the recovery of critical elements in substantially pure form from lithium ion batteries are provided. The systems and methods include supported membrane solvent extraction using an immobilized organic phase within the pores of permeable hollow fibers. The permeable hollow fibers are contacted by a feed solution on one side, and a strip solution on another side, to provide the simultaneous extraction and stripping of elements from dissolved lithium ion cathode materials, while rejecting other elements from the feed solution. The single- and multi-stage systems and methods can selectively recover cobalt, manganese, nickel, lithium, aluminum and other elements from spent battery cathodes and are not limited by equilibrium constraints as compared to traditional solvent extraction processes. |
| FILED | Wednesday, May 27, 2020 |
| APPL NO | 16/884189 |
| CURRENT CPC | Separation B01D 61/38 (20130101) B01D 69/08 (20130101) B01D 2325/02 (20130101) B01D 2325/20 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 23/0484 (20130101) C22B 26/12 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/525 (20130101) H01M 10/54 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376768 | Wilson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | Amy Charlene Wilson (Belton, Missouri) |
| ABSTRACT | An electrostatic energy harvester broadly comprises an electrical energy storage component, an electrical energy transfer stage, first and second variable capacitors, and a switching control module. The electrical energy transfer stage includes diode-connected transistors and dictates electrical energy transfer between the electrical energy storage component and the variable capacitors. The switching control module timely switches between the first and second variable capacitors according to a state machine. Subsequent electrical energy investments from the electrical energy storage component are less than an initial electrical energy investment due to remnant electrical energy remaining at the previously active one of the first and second variable capacitors from previous electrical energy harvesting. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 16/889874 |
| CURRENT CPC | Electric Machines Not Otherwise Provided for H02N 1/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376769 | Wilson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | Amy Charlene Wilson (Belton, Missouri) |
| ABSTRACT | An electrostatic energy harvester broadly comprises an electrical energy storage component, an electrical energy transfer stage, first and second variable capacitors, and a switching control module. The electrical energy transfer stage includes diode-connected transistors and dictates electrical energy transfer between the electrical energy storage component and the variable capacitors. The switching control module timely switches between the first and second variable capacitors according to a state machine. Subsequent electrical energy investments from the electrical energy storage component are less than an initial electrical energy investment due to remnant electrical energy remaining at the previously active one of the first and second variable capacitors from previous electrical energy harvesting. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 16/889882 |
| CURRENT CPC | Electric Machines Not Otherwise Provided for H02N 1/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376770 | Wilson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| ASSIGNEE(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (KANSAS CITY, Missouri) |
| INVENTOR(S) | Amy Charlene Wilson (Belton, Missouri) |
| ABSTRACT | An electrostatic energy harvester broadly comprises an electrical energy storage component, an electrical energy transfer stage, first and second variable capacitors, and a switching control module. The electrical energy transfer stage includes diode-connected transistors and dictates electrical energy transfer between the electrical energy storage component and the variable capacitors. The switching control module timely switches between the first and second variable capacitors according to a state machine. Subsequent electrical energy investments from the electrical energy storage component are less than an initial electrical energy investment due to remnant electrical energy remaining at the previously active one of the first and second variable capacitors from previous electrical energy harvesting. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 16/889890 |
| CURRENT CPC | Electric Machines Not Otherwise Provided for H02N 1/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376773 | Lorimer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Spark Thermionics, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam G. Lorimer (Berkeley, California); Jared William Schwede (Berkeley, California) |
| ABSTRACT | A system for combined heat and electric power generation, preferably including a heat reservoir and one or more electric generators, each preferably including a heat source and an energy converter. A method for combined heat and electric power generation, preferably including activating an electric generator, deactivating the electric generator, and/or providing heat from a heat reservoir. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/395998 |
| CURRENT CPC | Electric Machines Not Otherwise Provided for H02N 10/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210377461 | Hammer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. Hammer (Westchester, Illinois); Antonino Miceli (Northfield, Illinois); Chris J. Jacobsen (Naperville, Illinois) |
| ABSTRACT | A detector for imaging and efficiently digitizing a spatial distribution of photon flux includes pixel circuits that compressively encode pixel values generated by integrated analog to digital converters (ADCs). On-pixel digital compression circuits (DCCs) implement compression to increase continuous frame rate by reducing the number of bits per pixel while keeping quantization error below Poisson noise. Several mapping algorithms for photon-counting and charge-integrating detectors and compact digital logic implementations are presented. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 16/887706 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/04 (20130101) G01N 2223/413 (20130101) Measurement of Nuclear or X-radiation G01T 1/17 (20130101) Pictorial Communication, e.g Television H04N 5/321 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210377477 | Fahim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Farah Fahim (Glen Ellyn, Illinois); Tom Zimmerman (St. Charles, Illinois); Grzegorz Deptuch (Forest Park, Illinois) |
| ABSTRACT | A compact ADC circuit can include one or more comparators, and a serial DAC (Digital-to-Analog) circuit that provides a signal to the comparator (or comparators). In addition, the ADC circuit can include a serial DAC redistribution sequencer that can provide a plurality of signals as input to the serial DAC circuit and is subject to a redistribution cycle and which receives as input a signal from a data multiplexer whose input connects electronically to an output of the comparator. The circuit can further include an ADC code register that provides an ADC output that connects electronically to the output of the comparator and the input to the data multiplexer. Shared logic circuitry for sharing common logic between pixels can be included, wherein the shared logic circuitry connects electronically to the data multiplexer and the ADC code register, wherein the shared logic circuitry promotes area and power savings for the pixel detector circuit. |
| FILED | Wednesday, August 04, 2021 |
| APPL NO | 17/394351 |
| CURRENT CPC | Pulse Technique H03K 5/2472 (20130101) Coding; Decoding; Code Conversion in General H03M 1/462 (20130101) H03M 1/466 (20130101) Pictorial Communication, e.g Television H04N 5/378 (20130101) Original (OR) Class H04N 5/3698 (20130101) H04N 5/3741 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210369163 | HU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The MITRE Coporation (McLean, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | Qian HU (Lexington, Massachusetts); Matthew E. COARR (Newton, Massachusetts); Keith A. CROUCH (Cambridge, Massachusetts); Hiroshi N. FUJII (Waltham, Massachusetts); Joshua J. KRAUNELIS (Lowell, Massachusetts); Brian P. MARX (Sharon, Massachusetts); Terence M. KEANE (Brookline, Massachusetts) |
| ABSTRACT | Provided is a method for predicting a PTSD diagnosis in a patient comprising receiving audio input data from a patient; determining one or more audio input indicators based on the audio input data, wherein each audio input indicator of the one or more audio input indicators represents a likelihood of a positive PTSD diagnosis based on the audio input data; receiving clinical assessment data from the patient; determining one or more clinical assessment indicators based on the clinical assessment data, wherein each clinical assessment indicator of the one or more clinical assessment indicators represents a likelihood of a positive PTSD diagnosis based on the clinical assessment data; combining the one or more audio input indicators and the one or more clinical assessment indicators using a prediction model chosen by a clinician; and determining a PTSD diagnosis in the patient based on the audio input data and the clinical assessment data. |
| FILED | Monday, June 01, 2020 |
| APPL NO | 16/889296 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/165 (20130101) Original (OR) Class A61B 5/167 (20130101) A61B 5/4803 (20130101) A61B 5/7264 (20130101) A61B 5/7275 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 15/02 (20130101) G10L 25/63 (20130101) G10L 25/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369823 | Tomlinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MUSC Foundation For Research Development (Charleston, South Carolina); United States Government as Represented by the Department of Veteran Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Tomlinson (Charleston, South Carolina); DeAnna Adkins (Charleston, South Carolina); Ali Alawieh (Charleston, South Carolina) |
| ABSTRACT | The present invention describes compositions and method for improving outcomes after injury to the central nervous system wherein complement signaling is activated. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a therapeutic agent comprising a targeted inhibitor molecule comprising a targeting portion and an inhibitor portion, wherein the molecule inhibits complement, and wherein therapeutic agent is administered in combination with rehabilitation therapy or thrombolytic agent. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/320410 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/49 (20130101) A61K 38/57 (20130101) Original (OR) Class A61K 38/1709 (20130101) A61K 38/1725 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Peptides C07K 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210369863 | Mohapatra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | The United States Government as Represented by the Department of Veterans Affair (Washington, D.C., None) |
| INVENTOR(S) | Shyam S. Mohapatra (Lutz, Florida); Subhra Mohapatra (Lutz, Florida); Eleni Markousta (Tampa, Florida) |
| ABSTRACT | A multifunctional dendrimer nanoparticle and method of treating diseases of the posterior segment of the eye is presented. The functionalized polyamidoamine (PAMAM) dendrimer effectively delivers drugs and/or genes to the posterior eye, thereby providing for the effective, non-invasive, and topical treatment of diseased in the posterior eye. The multifunctional dendrimer nanoparticle has shRNA-encoding DNA and small molecule drug encapsulated cyclodextrin complexed to the outer surface of the dendrimer for delivery to the posterior segment of the eye. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/395683 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/4439 (20130101) A61K 31/7088 (20130101) A61K 47/60 (20170801) A61K 47/61 (20170801) A61K 47/62 (20170801) A61K 47/549 (20170801) A61K 47/6935 (20170801) Original (OR) Class A61K 47/6951 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/122 (20130101) C12N 2310/351 (20130101) C12N 2310/531 (20130101) C12N 2320/31 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371534 | Tomlinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC Foundation for Research Development (Charleston, South Carolina); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia); Universitat De Barcelona (Barcelona, Spain) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Tomlinson (Charleston, South Carolina); Ali Alawieh (Atlanta, Georgia); Pablo Engel (Barcelona, Spain) |
| ABSTRACT | The present invention describes compositions and methods for targeting complement inhibition to sites of p-selectin expression, and compositions for inhibiting p-selectin and complement. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335355 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 14/70596 (20130101) C07K 16/2854 (20130101) Original (OR) Class C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210371597 | Potkay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Govenment as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Potkay (Ann Arbor, Michigan); Elyse Fleck (Ann Arbor, Michigan) |
| ABSTRACT | Provided are photocurable resins comprising a poly(siloxane)-based copolymer together with a photoinitiator, and other optional ingredients such as a photocurable diluent, a photoabsorber, a photosensitizer, or a hydrophillic additive. Also provided are methods of stereolithographically printing a 3-D object from a disclosed resin. Also provided is an improved method for stereolithographically printing a 3-D object, the improvement comprising the use of a disclosed photocurable resin. Further provided is a 3-D microfluidic device such as an artificial lung prepared from a disclosed photocurable resin. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332655 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/1698 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/18 (20130101) Original (OR) Class Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) C12M 23/24 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0037 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/303 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374142 | Woods |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIR (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne S. Woods (San Francisco, California) |
| ABSTRACT | An intermediate data object is described that bridges source data to analysis-ready variables (ARVs). |
| FILED | Monday, November 04, 2019 |
| APPL NO | 17/290933 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2474 (20190101) G06F 16/2477 (20190101) G06F 16/24561 (20190101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375472 | Czerniecki et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph M. Czerniecki (Washington, District of Columbia); Daniel Norvell (Washington, District of Columbia) |
| ABSTRACT | A system and methods for decision support are provided. In some aspects, the methods and systems determine a decision support model, determine one or more risk scores, and output the one or more risk scores. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335893 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210372622 | Dai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | Zhongtao Dai (West Hartford, Connecticut); Lance L. Smith (West Hartford, Connecticut); Jeffrey M. Cohen (Hebron, Connecticut) |
| ABSTRACT | A main mixer including a swirler along an axis, the swirler including an outer swirler with a multiple of outer vanes, and a center swirler with a multiple of center vanes and a swirler hub along the axis, the swirler hub including a fuel manifold and an inner swirler with a multiple of inner vanes that support a centerbody, the multiple of inner vanes interconnect the fuel manifold and the centerbody. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370154 |
| CURRENT CPC | Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/14 (20130101) F23R 3/286 (20130101) Original (OR) Class F23R 2900/03041 (20130101) F23R 2900/03042 (20130101) F23R 2900/03044 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373157 | PIERROTTET et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DIEGO F. PIERROTTET (POQUOSON, Virginia); GLENN D. HINES (YORKTOWN, Virginia); FARZIN AMZAJERDIAN (YORKTOWN, Virginia) |
| ABSTRACT | An FMCW Doppler lidar system and method for use in a host vehicle includes a laser system, lenses, a homodyne receiver, and a signal processing unit (SPU). The laser beam is modulated to generate a frequency waveform with three segments, i.e., Doppler, up-ramp, and down-ramp. The lenses transmit laser beams toward a target-of-interest, and receive return beams reflected from the target-of-interest. The homodyne receiver has photoreceptors configured to mix the return beams with a respective local oscillator beam to generate a three-section return waveform. The SPU is coupled to the photoreceptors and calculates a respective magnitude and frequency of an up-ramp, down-ramp, and/or Doppler IF section of the return waveform, estimates a sign of the IF sections, and calculates a range and/or velocity relative to the target-of-interest using the estimated sign, and controls the host vehicle using the range and/or velocity. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/329976 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4817 (20130101) G01S 17/34 (20200101) Original (OR) Class G01S 17/58 (20130101) G01S 17/89 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375495 | Shargots et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT Nuclear Energy, Inc. (Lynchburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott J. Shargots (Forest, Virginia); Scott Lee Fitzner (Appomattox, Virginia); Emily Fleming (Forest, Virginia); Ryan Z. Ziegler (Forest, Virginia); Todd Oswald (Charlotte, North Carolina); Earl Brian Barger (Goode, Virginia) |
| ABSTRACT | A nuclear fuel assembly for a nuclear reactor core, the fuel assembly having at least one fuel element including an elongated shell defining an interior volume, a lattice structure disposed within the interior volume, at least one flow channel extending through the lattice structure, at least one lattice site disposed in the lattice structure, and at least one fuel compact disposed within a corresponding one of the at least one lattice site, a first end cap including a boss having a first cross-sectional shape, the first end cap being affixed to a first end of the shell, and a second end cap including a first bore having a second cross-sectional shape, the second end cap being affixed to a second end of the shell, wherein the first cross-sectional shape of the boss is the same as the cross-sectional shape of the bore. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/334060 |
| CURRENT CPC | Nuclear Reactors G21C 3/322 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210376598 | Schwerman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| ASSIGNEE(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| INVENTOR(S) | Paul W. Schwerman (Phoenix, Arizona); George M. Brown, JR. (Peoria, Arizona); Richard L. Marshall (Glendale, Arizona) |
| ABSTRACT | Embodiments of a single event latch-up (SEL) protection circuit are provided, including: a first circuitry block coupled to a source of an input voltage a load, and digitally controlling a first switch; the first switch generates a load and senses an instantaneous load current iLoad. A second circuitry block is configured to generate an average iLoad and generate single event latch-up triggers (i.e., SEL fault detection) as a function of at least a comparison of the inst_iLoad and average iLoad; wherein this first circuitry block contains the analog based SET filtering needed to reduce false SEL triggers. A supervisor module generates on/off commands for the first switch, responsive to receiving the SEL detection in excess of a pre-programmed delay to provide the final SET filtering to prevent false SEL triggers. The first circuitry block removes the load voltage at N1 upon receiving an off command from the supervisor module. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/395658 |
| CURRENT CPC | Emergency Protective Circuit Arrangements H02H 1/0007 (20130101) H02H 3/0935 (20130101) H02H 9/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210377751 | Barsoum et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Constellation Designs, LLC (Anaheim, California) |
| ASSIGNEE(S) | Constellation Designs, LLC (Anaheim, California) |
| INVENTOR(S) | Maged F. Barsoum (San Jose, California); Christopher R. Jones (Pacific Palisades, California) |
| ABSTRACT | Communication systems are described that use signal constellations, which have unequally spaced (i.e. ‘geometrically’ shaped) points. In many embodiments, the communication systems use specific geometric constellations that are capacity optimized at a specific SNR, over the Rayleigh fading channel. In addition, ranges within which the constellation points of a capacity optimized constellation can be perturbed and are still likely to achieve a given percentage of the optimal capacity increase compared to a constellation that maximizes dmin, are also described. Capacity measures that are used in the selection of the location of constellation points include, but are not limited to, parallel decode (PD) capacity and joint capacity. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/346153 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0003 (20130101) H04L 1/0009 (20130101) H04L 5/006 (20130101) H04L 27/3405 (20130101) Wireless Communication Networks H04W 24/02 (20130101) Original (OR) Class H04W 72/0453 (20130101) H04W 72/0473 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210371938 | Knight et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Biota Technology, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rob Knight (San Diego, California); Ajay Kshatriya (Oakland, California); Chris Lauber (Boulder, Colorado); J. Gregory Caporaso (Flagstaff, Arizona); Dan Knights (St. Paul, Minnesota); Ryan Gill (Denver, Colorado); Joel Moxley (Highlands Ranch, Colorado) |
| ABSTRACT | There are provided methods, systems and processes for the utilization of microbial and related genetic information for use in industrial settings, such as the exploration, determination, and recovery of natural resources, minerals, and energy sources, the monitoring and analysis of processes, activities, and materials transmission. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/245822 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/582 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6888 (20130101) Original (OR) Class C12Q 2600/156 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/16 (20130101) E21B 47/11 (20200501) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 10/00 (20190201) G16B 20/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372994 | Metzger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE ROCKEFELLER UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jakob Metzger (New York, New York); Fred Etoc (New York, New York); Ali Brivanlou (New York, New York); Eric Siggia (New York, New York) |
| ABSTRACT | Systems and methods for identifying molecules that are biologically active against a disease, where the method can comprise culturing a first mammalian cell population under organoid formation conditions in the presence of a test molecule to obtain a first organoid, wherein the first mammalian cell population, when cultured under the organoid formation conditions in the absence of the test molecule, results in an organoid with a disease phenotype; imaging the first organoid following exposure to the test molecule; analyzing one or more images of the first organoid using a neural network that has been trained to assign a probability score of disease or non-disease ranging between 0% and 100%; assigning the first organoid a probability score ranging between 0% and 100%; wherein the test molecule is biologically active against the disease if the probability score of the first organoid is greater than a cutoff probability score of non-disease or lower than a cutoff probability score of disease. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282039 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 2503/02 (20130101) C12N 2510/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 33/5014 (20130101) G01N 33/5076 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00147 (20130101) G06K 9/6256 (20130101) G06K 9/6262 (20130101) G06K 2209/05 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2200/04 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) G06T 2207/30072 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373338 | Gao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Magic Leap, Inc. (Plantation, Florida) |
| ASSIGNEE(S) | Magic Leap, Inc. (Plantation, Florida) |
| INVENTOR(S) | Chunyu Gao (Tucson, Arizona); Yuxiang LIN (Tucson, Arizona); Hong HUA (Tucson, Arizona) |
| ABSTRACT | The present invention comprises a compact optical see-through head-mounted display capable of combining, a see-through image path with a virtual image path such that the opaqueness of the see-through image path can be modulated and the virtual image occludes parts of the see-through image and vice versa. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127316 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 13/06 (20130101) G02B 25/001 (20130101) G02B 27/144 (20130101) G02B 27/0172 (20130101) Original (OR) Class G02B 27/283 (20130101) G02B 27/1066 (20130101) Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 37/02 (20130101) Image Data Processing or Generation, in General G06T 19/006 (20130101) Pictorial Communication, e.g Television H04N 5/2258 (20130101) H04N 5/23238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375459 | Longmire et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Medable Inc. (Palo Alto, California) |
| ASSIGNEE(S) | Medable Inc. (Palo Alto, California) |
| INVENTOR(S) | Michelle Longmire (PALO ALTO, California); Ingrid Oakley-Girvan (Henderson, California); NICK MOSS (Los Alamos, New Mexico); Reem Yunis (Menlo Park, California); Anushka Manoj Gupta (RALEIGH, North Carolina) |
| ABSTRACT | The instant system and method will be a scalable and flexible software platform to agnostically capture wearable, implantable, or external device data and create a digital biomarker for various disease conditions, care and analysis. The system and method also provides an informatics tool for automated data aggregation, integration, and machine learning algorithms to uniformly compare/contrast/couple data streams as a function of patient and context over time. The focus is on user engagement and usability, accessibility and reporting to the clinical care team, and usability by researchers interested in analyzing data and outcomes. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/219867 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/00 (20180101) G16H 40/67 (20180101) G16H 50/20 (20180101) Original (OR) Class G16H 50/50 (20180101) G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210368767 | Haff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald P. Haff (Albany, New York); Eric S. Jackson (Albany, California); Robert M. Hnasko (Albany, California) |
| ABSTRACT | Packages of insects are attached to a carrier cylinder and the cylinder is rotated in a radiation field so that the packaged insects are sterilized. The radiation field is created by a plurality of x-ray tubes mounted above the carrier cylinder. The tubes (and their respective radiation sources) are positioned so that a consistent radiation dosage is delivered at the surface of the cylinder—thereby imparting both a precise and uniform dose of radiation to the insect packages affixed to the surface of the cylinder. |
| FILED | Tuesday, May 26, 2020 |
| APPL NO | 16/883221 |
| CURRENT CPC | Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants A01M 1/226 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210368833 | Sablani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington State University (Pullman, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shyam S. Sablani (Pullman, Washington); Joseph R. Powers (Pullman, Washington) |
| ABSTRACT | Methods of stabilizing produce, such as fruits and vegetables, are provided. In particular, the methods comprise vacuum impregnating the item of produce in an infusion solution containing a polysaccharide, partially drying the item of produce to reduce its water content below its original harvest-level of hydration, and optionally applying an edible coating to the item of produce. Subsequently frozen items of produce display improved mechanical properties and visual integrity. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/329217 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 3/44 (20130101) A23L 3/375 (20130101) Original (OR) Class A23L 3/3562 (20130101) A23L 29/256 (20160801) A23L 29/262 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210368844 | Meydani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tufts University (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simin Nikbin Meydani (Newton, Massachusetts); Mohsen Meydani (Newton, Massachusetts) |
| ABSTRACT | Provided herein are compositions and methods for treating, preventing, and reducing the risk of obesity and related diseases and conditions. In particular, provided herein is a composition comprising a dry powder of fruits and vegetables and uses thereof. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400409 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/30 (20160801) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 36/23 (20130101) A61K 36/45 (20130101) A61K 36/81 (20130101) A61K 36/752 (20130101) A61K 36/899 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20210370013 | Jacobs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Bryson Jacobs (Quaker Hill, Connecticut); Savannah Lyle (Saint Petersburg, Florida) |
| ABSTRACT | In an example, a ventilator includes an outer container containing liquid, an inverted container submerged in the liquid to provide inverted container space between a closed top and an inner container liquid level; gas supply line to supply breathing gas to the inverted container space; and inhalation line having an inlet in the inverted container space to provide breathing gas to patient. The inverted container moves upward from a first elevation when the inverted container space reaches a hydrostatic delivery pressure and volume of the inverted container space increases. The inverted container stops moving upward and the gas supply line stops supplying when the inverted container reaches a second elevation above the first. Based on a breath demand signal or preset timing, the inhalation line opens to permit flow of breathing gas to the patient at the hydrostatic delivery pressure, lowering the inverted container due to lost buoyancy resulting in sinkage. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244728 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0003 (20140204) A61M 16/16 (20130101) Original (OR) Class A61M 16/208 (20130101) A61M 2205/3348 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373150 | Vemury |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Arun Vemury (North Bethesda, Maryland) |
| ABSTRACT | In an example, information related to a user of a mobile device and to an item associated with the user is received from a network. Based on the information a screening threshold is determined. The screening threshold is communicated to an electronic physical screening device and a direction instruction, indicating a location of a physical screening area corresponding to the electronic physical screening device, is communicated to the mobile device. The direction instruction causes the mobile device to display a direction information, directing the user to the physical screening area, for a physical screening in accordance with the threshold. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/401028 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/887 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) Wireless Communication Networks H04W 4/029 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210377742 | Boyd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Apple Inc. (Cupertino, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel A. Boyd (Arlington, Virginia); Kelli L. Biegger (McLean, Virginia); Chang Ellison (Arlington, Virginia); Brandon P. Gutierrez (Burke, Virginia); Jason Lim (Alexandria, Virginia) |
| ABSTRACT | An embodiment includes a method to increase the efficiency of security checkpoint operations. A security checkpoint kiosk serves as a Relying Party System (RPS). The RPS establishes a secure local connection between the RPS and a User Mobile-Identification-Credential Device (UMD). The RPS sends a user information request to the UMD, via the secure local connection, seeking release of user information associated with a Mobile Identification Credential (MIC). The RPS obtains authentication of the user information received in response to the user information request. The RPS retrieves user travel information based on the user information. The RPS determines that the user travel information matches the user information. When the user travel information matches the user information, the RPS approves the user to proceed past the security checkpoint kiosk. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 17/398723 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/265 (20130101) Wireless Communication Networks H04W 4/80 (20180201) H04W 12/02 (20130101) H04W 12/037 (20210101) H04W 12/47 (20210101) H04W 12/69 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20210371073 | Pascucilla |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | East Shore District Health Department (Branford, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. Pascucilla (Guilford, Connecticut) |
| ABSTRACT | A solar electric pump-out boat for removing human waste. The pump-out boat may include a boat hull, wherein the boat hull may include a bow, a stern, and a self-draining sole disposed therein. The pump-out boat may further include a holding tank disposed within the hull underneath the self-draining sole for collecting waste. The pump-out boat may further include a console disposed approximately center of, and on a top surface of the self-draining sole. The pump-out boat may further include a solar panel for absorbing sunlight to convert into electrical power. The pump-out boat may further include a pump disposed within the console. The pump-out boat may further include a battery connected to a motor, the pump, and the solar panel, such that the solar panel charges the battery to provide the electrical power to operate the pump and the motor. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/077151 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 29/16 (20130101) Marine Propulsion or Steering B63H 21/17 (20130101) Original (OR) Class B63H 2021/171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372941 | Pellerin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES GEOLOGICAL SURVEY (Reston, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Anthony Pellerin (Herndon, Virginia); Angela Merleen Hansen (Sacramento, California) |
| ABSTRACT | A multiparameter standard solution for verifying and calibrating water quality sensors containing an aqueous pH buffer, a xanthene dye, and distyryl biphenyl (DSBP) is provided. The standard solution provides a safe, quick, easy, and stable field standard to simultaneously conduct calibration analysis for several sensors at once. The standard solution is stable when stored and can be safely disposed of in the field. Methods of calibrating sensors used in water quality analysis using the multiparameter standard solution are also provided. |
| FILED | Saturday, November 21, 2020 |
| APPL NO | 17/100859 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/93 (20130101) Original (OR) Class G01N 33/18 (20130101) G01N 2201/13 (20130101) G01N 2201/12715 (20130101) G01N 2201/12746 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20210368795 | Mandadi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kranthi Mandadi (Weslaco, Texas); Manikandan Ramasamy (Weslaco, Texas); Prakash Niraula (Weslaco, Texas); Sonia Irigoyen (Weslaco, Texas) |
| ABSTRACT | Applicants have developed novel methods and compositions for treating, preventing or ameliorating the effects plant phytopathogen infestation in plants, including of Candidatus Liberibacter spp. the causal agents of citrus greening and potato zebrachip disease. Novel compositions include one or more active agents of aminocaproic acid, carbinoxamine maleate, chloroxylenol, chlorpropamide, cinoxacin, duartin, and cyclopentolate hydrochloride as well as their derivatives, or salt/acid forms thereof. Methods of preventing disease development and infestation by plant pathogens are disclosed as well as methods of making, using and producing such compositions. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/303367 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 31/04 (20130101) A01N 33/04 (20130101) A01N 37/44 (20130101) A01N 41/10 (20130101) A01N 43/42 (20130101) A01N 43/90 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210374953 | Asiedu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mercy Asiedu (Durham, North Carolina); Nirmala Ramanujam (Durham, North Carolina); Guillermo Sapiro (Durham, North Carolina) |
| ABSTRACT | A method for automated detection of cervical pre-cancer includes: providing at least one cervigram; pre-processing the at least one cervigram; extracting features from the at least one pre-processed cervigram; and classifying the at least one cervigram as negative or positive for cervical pre-cancer based on the extracted features. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282093 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/136 (20170101) G06T 7/168 (20170101) G06T 2207/20024 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20132 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20210376555 | ZHANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (DENVER, Colorado); Government of the United States of America as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | WEI ZHANG (BOULDER, Colorado); LIRON STERN (BOULDER, Colorado); SCOTT B. PAPP (BOULDER, Colorado) |
| ABSTRACT | A monolithic photonic resonator includes a bulk optic with first and second superpolished facets, and a high-reflectivity coating applied to each of the first and second superpolished facets. The superpolished facets form an optical resonator. The bulk optic is a single piece of an optical material that is solid, i.e., has no internal holes, gaps, or pockets. The bulk optic therefore serves as an intraresonator optical medium while still supporting a finesse of 10,000 or more. The superpolished facets may be counterfacing to form a Fabry-Perot cavity. Alternatively, the bulk optic may include forms one or more additional facets off of which light inside the bulk optic undergoes total internal reflection. The monolithic photonic resonator may be mounted in a support structure that minimizes the overall vibration sensitivity of the resonator's resonance frequency. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331424 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/061 (20130101) H01S 3/0407 (20130101) H01S 3/1305 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20210371304 | RYU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Environmental Protection Agency (Washington, District of Columbia) |
| ASSIGNEE(S) | U.S. Environmental Protection Agency (Washington, District of Columbia) |
| INVENTOR(S) | HODON RYU (CINCINNATI, Ohio); HYOUNGMIN WOO (CINCINNATI, Ohio) |
| ABSTRACT | A point-of-use (POU) water filtration device has a container. A plurality of channels is formed within the container, water entering the container flowing through the plurality of channels. A plurality of Ultraviolet (UV) Light Emitting Diodes (LEDs) is provided. Each of the plurality of UV LEDs illuminating UV light down an associated channel of the plurality of channels. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/386228 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/10 (20130101) A61L 2/26 (20130101) A61L 2/088 (20130101) A61L 2202/11 (20130101) A61L 2202/122 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/325 (20130101) Original (OR) Class C02F 1/725 (20130101) C02F 2201/3222 (20130101) C02F 2201/3227 (20130101) C02F 2201/3228 (20130101) C02F 2303/04 (20130101) C02F 2305/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Geospatial Intelligence Agency (NGA)
| US 20210374953 | Asiedu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mercy Asiedu (Durham, North Carolina); Nirmala Ramanujam (Durham, North Carolina); Guillermo Sapiro (Durham, North Carolina) |
| ABSTRACT | A method for automated detection of cervical pre-cancer includes: providing at least one cervigram; pre-processing the at least one cervigram; extracting features from the at least one pre-processed cervigram; and classifying the at least one cervigram as negative or positive for cervical pre-cancer based on the extracted features. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282093 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/136 (20170101) G06T 7/168 (20170101) G06T 2207/20024 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20132 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20210376933 | Liang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Di Liang (Santa Barbara, California); Zhihong Huang (Palo Alto, California) |
| ABSTRACT | Systems and methods are provided for receiving an optical signal from an optical fiber, including: coupling via an optical coupler the optical signal from an optical fiber into first and second waveguides, wherein the optical signal comprises TE and TM polarized optical signals and the optical coupler couples the TE polarized optical signal into the first waveguide and the TM polarized optical signal into the second waveguide; equalizing the TE and TM polarized optical signals from the coupler to equalize optical power levels of the TE and TM polarized optical signals; optically combining the equalized TE and TM polarized optical signals; and transmitting the combined optical signal to a photodetector. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 16/891008 |
| CURRENT CPC | Transmission H04B 10/6151 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20210368833 | Sablani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington State University (Pullman, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shyam S. Sablani (Pullman, Washington); Joseph R. Powers (Pullman, Washington) |
| ABSTRACT | Methods of stabilizing produce, such as fruits and vegetables, are provided. In particular, the methods comprise vacuum impregnating the item of produce in an infusion solution containing a polysaccharide, partially drying the item of produce to reduce its water content below its original harvest-level of hydration, and optionally applying an edible coating to the item of produce. Subsequently frozen items of produce display improved mechanical properties and visual integrity. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/329217 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 3/44 (20130101) A23L 3/375 (20130101) Original (OR) Class A23L 3/3562 (20130101) A23L 29/256 (20160801) A23L 29/262 (20160801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20210370353 | MCGRATH |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES POSTAL SERVICE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph W. MCGRATH (Arlington, Virginia) |
| ABSTRACT | Systems and methods for sorting delivery items are disclosed. The system may include an intake area, a sorting area operably coupled with the intake area, and a computing system operably coupled with the intake area and the sorting area. The intake area may include a source of delivery items having a plurality of delivery items, and a scanner for scanning respective indicia of each of the plurality of delivery items. The sorting area may include a conveyor having a respective sensor disposed at opposing end portions thereof, one or more sort locations disposed about the conveyor, and one or more indicators configured to indicate a proper sort location for the delivery items. The computing system may receive data corresponding to a delivery item from the scanner, determine the proper sort location for the delivery item, and send a signal to the indicator to indicate the proper sort location. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335783 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/10 (20130101) B07C 3/18 (20130101) Original (OR) Class B07C 2301/0008 (20130101) Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 1/023 (20130101) B65G 2203/0216 (20130101) B65G 2203/0233 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 5/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20210372290 | Krumanaker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Lee Krumanaker (Blue Ash, Ohio); Thomas Joseph Lipinski (Monroe, Ohio) |
| ABSTRACT | A turbine engine comprising an engine core comprising at least a compressor section, a combustor section, and a turbine section and defining a rotor and a stator. The turbine engine further comprising a first seal structure circumferentially extending about the rotor, a plurality of circumferentially arranged vanes, a plurality of struts extending through the vanes, and a second seal structure extending circumferentially about the first seal structure. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 16/890473 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/025 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/28 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210372753 | Shott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig O. Shott (Tucson, Arizona); Brayden Peery (Tucson, Arizona); Gary W. Liles (Tucson, Arizona); Alex Karwas (Tucson, Arizona); Gregory J. Larson (Vail, Arizona) |
| ABSTRACT | A projectile including an ejectable aft fin housing assembly. The aft fin housing assembly includes aft fins that increase a distance between a center of gravity and a center of pressure of the projectile, improving passive stabilization of the projectile. Once the projectile has been passively stabilized, the aft fin housing assembly is ejected, decreasing a distance between the center of gravity and the center of pressure, improving active stabilization of the projectile. |
| FILED | Monday, June 01, 2020 |
| APPL NO | 16/889003 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 10/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210373206 | Starkovich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northrop Grumman Systems Corporation (Falls Church, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Starkovich (Redondo Beach, California); Kevin J. Salvini (Lawndale, California); Edward M. Silverman (Encino, California) |
| ABSTRACT | An optical absorber and method of manufacture is disclosed. A non-woven sheet of randomly-organized horizontally-oriented carbon nanotubes (CNTs) is subjected to a laser rasterizing treatment at ambient temperature and pressure. The upper surface of the sheet is functionalized by oxygen and hydrogen atoms resulting in improved absorbance properties as compared to untreated CNT sheets as well as to commercial state-of-art black paints. Laser treatment conditions may also be altered or modulated to provide surface texturing in addition to functionalization to enhance light trapping and optical absorbance properties. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354124 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/168 (20170801) Optical Elements, Systems, or Apparatus G02B 1/04 (20130101) G02B 1/12 (20130101) G02B 5/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210375713 | HATHAWAY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AARON ASHLEY HATHAWAY (BALTIMORE, Maryland); GREGORY R. BOYD (WASHINGTON, District of Columbia); JOHN X. PRZYBYSZ (SEVERNA PARK, Maryland) |
| ASSIGNEE(S) | NORTHROP GRUMMAN SYSTEMS CORPORATION (FALLS CHURCH, Virginia) |
| INVENTOR(S) | AARON ASHLEY HATHAWAY (BALTIMORE, Maryland); GREGORY R. BOYD (WASHINGTON, District of Columbia); JOHN X. PRZYBYSZ (SEVERNA PARK, Maryland) |
| ABSTRACT | An integrated circuit is provided that comprises a first thermal sink layer, a first ground plane associated with a first set of circuits that have a first operational temperature requirement, a first thermally conductive via that couples the first ground plane to the first thermal sink layer, a second thermal sink layer, a second ground plane associated with a second set of circuits that have a second operational temperature requirement that is higher than the first operational temperature requirement, and a second thermally conductive via that couples the second ground plane to the second thermal sink layer. The first thermal sink layer is cooled at a first temperature to maintain the first set of circuits at the first operational temperature requirement and the second thermal sink layer is cooled at a second temperature to maintain the second set of circuits at the second operational temperature requirement. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/222238 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/66 (20130101) H01L 23/367 (20130101) Original (OR) Class H01L 23/5226 (20130101) H01L 23/5286 (20130101) H01L 23/53285 (20130101) H01L 2223/6605 (20130101) H01L 2223/6683 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, December 02, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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