FedInvent™ Patent Applications
Application Details for Thursday, December 09, 2021
This page was updated on Friday, December 10, 2021 at 02:51 PM GMT
Department of Health and Human Services (HHS)
| US 20210378511 | Skubic et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marjorie Skubic (Columbia, Missouri); Marilyn J. Rantz (Rocheport, Missouri); Mihail Popescu (Columbia, Missouri); Shuang Wang (Irvine, California); Isaac J. Sledge (Columbia, Missouri); Rainer Dane A. Guevara (Columbia, Missouri); Elena Florea (Columbia, Missouri); James M. Keller (Columbia, Missouri) |
| ABSTRACT | Methods and systems for an integrated sensor network are described. In one embodiment, sensor data may be accessed from a plurality of motion sensors and a bed sensor deployed in a living unit for a first time period. An activity pattern for the first time period may be identified based on at least a portion of sensor data associated with the first time period. The activity pattern may represent a physical and cognitive health condition of a person residing in the living unit. Additional sensor data may be accessed from the motion sensors and the bed sensor deployed for a second time period. A determination of whether a deviation of the activity pattern of the first time period has occurred for the second time period may be performed. An alert may be generated based on a determination that the derivation has occurred. In some embodiments, user feedback is captured on the significance of the alerts, and the alert method is customized based on this feedback. Additional methods and systems are disclosed. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/409974 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/002 (20130101) Original (OR) Class A61B 5/021 (20130101) A61B 5/0022 (20130101) A61B 5/0205 (20130101) A61B 5/1113 (20130101) A61B 5/1118 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/0423 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378529 | COLBURN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | David COLBURN (New York, New York); Samuel K. SIA (New York, New York) |
| ABSTRACT | The disclosed subject matter includes a wearable device for blood pressure monitoring. The embodiments employ a set of sensors to calculate a relative external pressure. A transmural pressure error can be calculated based on the relative external pressure. A measured transmural pressure can be corrected based on the transmural pressure error. Some embodiments track altitude to calculate relative external pressure error. Some embodiments track arm orientation to calculate relative external pressure error. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400485 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/725 (20130101) A61B 5/02125 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 5/7278 (20130101) A61B 2560/0223 (20130101) A61B 2560/0257 (20130101) A61B 2562/0219 (20130101) A61B 2562/0223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378581 | Barlow, Ph.D. et al. |
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| FUNDED BY |
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| APPLICANT(S) | Innara Health, Inc. (Olathe, Kansas) |
| ASSIGNEE(S) | Innara Health, Inc. (Olathe, Kansas) |
| INVENTOR(S) | Steven M. Barlow, Ph.D. (Lawrence, Kansas); David L. Stalling, Ph.D. (Olathe, Kansas); Kenneth Aron (Olathe, Kansas) |
| ABSTRACT | A neural analysis and treatment system includes a computing device with a memory for storing an application that is executable on a processor to receive amplitude-integrated electroencephalography (aEEG) and range-EEG (rEEG) measurements associated with a patient. The systems determine a spectral edge frequency (SEF) measurement from the received EEG measurements, and determine one or more neural characteristics of the patient according to the determined SEF, aEEG, and rEEG measurements. These neural characteristics may then be used to identify and implement an appropriate therapeutic treatment. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407979 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/374 (20210101) A61B 5/377 (20210101) Original (OR) Class A61B 5/7242 (20130101) A61B 2503/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378627 | Yarmush et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Martin L. Yarmush (New Brunswick, New Jersey); Alvin Chen (New Brunswick, New Jersey); Max Balter (New Brunswick, New Jersey); Joshua Leipheimer (New Brunswick, New Jersey) |
| ABSTRACT | A device and method for directing a cannula toward a target location under a patient's skin. The device is handheld and the device operations may be automated. The device includes an imaging probe for imaging the target location, a positioning unit for manipulating a cannula towards the target location, and a processor. The processor receives imaging data from the imaging probe, cannula pose data from at least one cannula position sensor, and device pose data from at least one device position sensor. The target location is identified from the imaging data, and a trajectory for manipulating the cannula towards the target location is determined based on the imaging data, the cannula pose data, and the device pose data. The processor may determine that the trajectory becomes misaligned with the target position, and may update to a corrected trajectory based on the imaging data, cannula pose data, and the device pose data. |
| FILED | Wednesday, October 09, 2019 |
| APPL NO | 17/284018 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) A61B 8/12 (20130101) A61B 8/466 (20130101) A61B 8/0841 (20130101) Original (OR) Class A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378904 | Lerner et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary F. Lerner (Flagstaff, Arizona); Grigoriy Orekhov (Flagstaff, Arizona) |
| ABSTRACT | A low-weight, high performance wearable assistive device for assisting motion of a joint of a wearer (e.g., an ankle) and/or resistance training of motion of the joint includes a lightweight upright member that may be attached to the wearer (e.g., fastened to the wearer's outside calf). Forces to assist or resist movement of the joint are coupled to a rotation bearing via cables. The bearing is disposed within the upright member such torsional deflection of the device under load is reduced, allowing the upright member to be lighter and/or less obtrusive to the wearer and less susceptible to failure. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343628 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0266 (20130101) A61H 3/00 (20130101) Original (OR) Class A61H 2201/149 (20130101) A61H 2201/165 (20130101) A61H 2201/1642 (20130101) A61H 2201/5061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378918 | Aparicio et al. |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Conrado Aparicio (Minneapolis, Minnesota); Nicholas G. Fischer (Minneapolis, Minnesota) |
| ABSTRACT | An ultraviolet photopolymerizable composition for soft tissue attachment includes trimethylolpropane tris(3-mercaptopropionate) (TMTMP), a photoinitiator, a solvent, and one or more of trimethylolpropane trimethacrylate (TMPTMA), pentaerythritol triacrylate (PETA), dopamine methacrylamide (DMA), and n-phenethylmethacrylamide (PEMAD). Coating a substrate with a polymeric coating includes contacting a substrate with the ultraviolet photopolymerizable and irradiating the composition with ultraviolet radiation to yield a polymeric coating on the substrate. Treating a substrate includes contacting the substrate with the composition and irradiating the composition with ultraviolet radiation to yield a polymeric coating on the substrate. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/339243 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 6/30 (20200101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/34 (20130101) A61L 29/085 (20130101) A61L 2420/02 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 222/103 (20200201) C08F 222/104 (20200201) C08F 2810/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378947 | AMIJI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts); Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mansoor M. AMIJI (Attleboro, Massachusetts); Smrithi PADMAKUMAR (Brighton, Massachusetts); Benjamin S. BLEIER (Boston, Massachusetts) |
| ABSTRACT | A method of delivering a therapeutic agent into the central nervous system through the blood-brain barrier includes implanting an implant within the submucosal space of the olfactory epithelium. The implant can provide sustained drug delivery to the brain. The implant can be placed using a minimally invasive surgical approach. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/338505 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0004 (20130101) Original (OR) Class A61K 9/0043 (20130101) A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378949 | Nguyen et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thanh Duc Nguyen (South Windsor, Connecticut); Eli Curry (Franklin, Connecticut); Ritopa Das (West Springfield, Massachusetts); Yang Liu (Willimantic, Connecticut) |
| ABSTRACT | Methods, systems, and apparatus, including combination therapy systems for the treatment of infections. These systems comprising: an ultrasound device capable of producing ultrasonic acoustic pressure; and a biodegradable piezoelectric film comprising polymer-based piezoelectric material, poly(L-lactic acid) (PLLA) nanofiber mesh configured to, when placed in an electrolytically conductive environment comprising water and stimulated with the ultrasonic acoustic pressure, vibrate generating electricity to locally decomposes the water into reactive oxygen species (ROS) to induce a broad-spectrum bactericidal effect. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/342470 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) Original (OR) Class A61K 9/70 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/26 (20130101) A61L 15/64 (20130101) A61L 15/425 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Compositions of Macromolecular Compounds C08L 67/04 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378959 | HUANG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shao-Ling HUANG (Houston, Texas); Melvin E. KLEGERMAN (Houston, Texas); Yong-Jian GENG (Houston, Texas); Hyunggun KIM (Houston, Texas); David D. MCPHERSON (Houston, Texas) |
| ABSTRACT | Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229627 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) Original (OR) Class A61K 33/00 (20130101) A61K 41/0028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378976 | XIE |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin XIE (Watkinsville, Georgia) |
| ABSTRACT | Disclosed are particles comprising lithium salts and methods for their use in treating inflammatory conditions. |
| FILED | Friday, January 18, 2019 |
| APPL NO | 16/962946 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/5115 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 9/5161 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378991 | Lu et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Daniel C. Lu (Los Angeles, California); V. Reggie Edgerton (Los Angeles, California); Roland R. Roy (Playa Vista, California); Yury P. Gerasimenko (Los Angeles, California) |
| ABSTRACT | In various embodiments, methods are provided for applying transcutaneous and/or epidural spinal cord stimulation with and without selective pharmaceuticals to restore voluntary control of hand function in tetraplegic subjects. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/407043 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Original (OR) Class A61K 31/496 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/527 (20130101) A61K 31/4168 (20130101) A61K 31/4178 (20130101) A61K 31/4985 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0551 (20130101) A61N 1/36003 (20130101) A61N 1/36034 (20170801) A61N 1/36067 (20130101) A61N 1/36171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378999 | GERNER et al. |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona); CANCER PREVENTION PHARMACEUTICALS, INC. (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene GERNER (Tucson, Arizona); Elizabeth BRUCKHEIMER (Tucson, Arizona) |
| ABSTRACT | The present invention provides methods and kits a) for preventing and/or treating neuroblastoma (e.g., high-risk neuroblastoma) that is linked, in part, to high levels of ODC activity and increased cellular polyamine content, b) for predicting cancer patient survival, especially cancer patients whose cancer is linked, in part, to high levels of ODC activity and increased cellular polyamine contents, and c) for selecting treatment options for such patients based on the allelic nucleotide sequence or SNP at positions +263 and/or +316 of the ODC1 gene. The invention also provides, cancer treatment methods comprising the determination of the ODC1 genotype at the +263 and/or +316 positions, as a means to guide treatment selection, which includes, in some aspects the administration of pharmaceutically effective amounts of α-difluoromethylornithine (DFMO), either as a monotherapy or in combination with one or more other drugs. In addition, the present invention provides methods for preventing and/or treating patients that have been determined to have cancer stem cells, such as patients in cancer remission that are at risk for relapse. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/147697 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) A61K 31/192 (20130101) A61K 31/198 (20130101) Original (OR) Class A61K 31/203 (20130101) A61K 31/415 (20130101) A61K 31/616 (20130101) A61K 31/7048 (20130101) A61K 39/395 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/3084 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379012 | Corson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana); Gachon University of Industry-Academic Cooperation Foundation (Seongnam-si, Gyeonggi-do, South Korea); KINGSTON UNIVERSITY (Kingston upon Thames, Surrey, United Kingdom); UNIVERSITY OF SURREY (Guildford, Surrey, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy W. Corson (Fishers, Indiana); Seung-Yong SEO (Seongnam-si, South Korea); Bit Lee (Saongnam-si, South Korea); Sianne SCHWIKKARO (Surrey, United Kingdom); Dulcie MULHOLLAND (Surrey, United Kingdom); Hannah WHITMORE (Surrey, United Kingdom) |
| ABSTRACT | A novel chromane derivative, (3′-hydroxy-4′-ethoxybenzyl)-5,6,7-trimethoxy-2H-1-benzopyran (SH-17059 (1)) is disclosed herein. This chromane derivative has been found to inhibit blood vessel cell growth and proliferation, providing a promising treatment for ocular angiogenesis-mediated diseases. |
| FILED | Monday, April 29, 2019 |
| APPL NO | 17/051807 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/353 (20130101) Original (OR) Class A61K 31/427 (20130101) A61K 31/506 (20130101) A61K 31/7072 (20130101) A61K 38/179 (20130101) A61K 39/3955 (20130101) Heterocyclic Compounds C07D 309/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379016 | BHUIYAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Shenuarin BHUIYAN (Shreveport, Louisiana); Christopher KEVIL (Shreveport, Louisiana); Anthony Wayne ORR (Benton, Louisiana); Chowdhury S ABDULLAH (Shreveport, Louisiana); Richa Aishwarya (Shreveport, Louisiana) |
| ABSTRACT | Therapeutics and methods of treating one of an angiotensin-converting enzyme 2 (ACE2) associated condition and an ACE2 associated pre-condition patient comprising administering to the patient a pharmaceutically therapeutic dose of a therapeutic, wherein the therapeutic includes either a Sigmar1 antagonist or any pharmaceutically acceptable salt, solvate, or prodrug thereof, or a Sigmar1 enhancer, or any pharmaceutically acceptable salt, solvate, or prodrug thereof. A method of treating coronavirus disease 2019 (COVID-19) patient comprising administering to the patient a pharmaceutically therapeutic dose of a therapeutic, wherein the therapeutic includes a Sigmar1 enhancer, or any pharmaceutically acceptable salt, solvate, or prodrug thereof. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/341249 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/57 (20130101) A61K 31/341 (20130101) A61K 31/445 (20130101) A61K 31/4015 (20130101) Original (OR) Class A61K 31/5375 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379030 | XIE et al. |
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| FUNDED BY |
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| APPLICANT(S) | Meharry Medical College (Nashville, Tennessee); Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hua XIE (Nashville, Tennessee); Chin-Ho CHEN (Durham, North Carolina) |
| ABSTRACT | The disclosure provides compounds that inhibit the invasion of host cells by intracellular parasites. These find use, for example, in treating and preventing periodontitis or a periodontitis-related condition or symptom. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/402998 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/042 (20130101) A61K 8/42 (20130101) A61K 8/0204 (20130101) A61K 8/4926 (20130101) A61K 31/166 (20130101) A61K 31/439 (20130101) Original (OR) Class A61K 31/4748 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/02 (20180101) A61P 31/04 (20180101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 11/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379039 | CHENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingwei CHENG (Melrose, Massachusetts); James DECAPRIO (Wellesley, Massachusetts); Donglim Esther PARK (Allston, Massachusetts) |
| ABSTRACT | The present invention relates to methods of treating p53 wild type (WT) tumors. In particular, the invention provides novel therapies for p53 WT tumors based on the combination of Mouse Double Minute 2 (MDM2) inhibitors, e.g. HDM201, together with Casein Kinase 1 alpha (CK1α) degrading agents and/or an MDM4 inhibitors, e.g. lenalidomide. The combination may be used in the treatment of solid as well as hematologic p53 WT tumors, e.g. Merkel cell carcinoma (MCC) or myelodysplastic syndrome (MDS). |
| FILED | Monday, October 28, 2019 |
| APPL NO | 17/289122 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/513 (20130101) A61K 31/4439 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379046 | Scheinberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | David A. Scheinberg (New York, New York); Claire Y. Oh (Colonia, New Jersey); Martin Gunther Klatt (New York, New York) |
| ABSTRACT | Provided herein are methods of modulating immune response, including methods of treating a cancer or an infection using a combination of kinase modulators and immunotherapy that promotes immune response. Also provided herein are methods of treating an autoimmune disease or graft-versus-host disease, and methods of reducing the risk of solid organ transplant rejection using a combination of kinase modulators and immunosuppressive therapy. |
| FILED | Thursday, October 31, 2019 |
| APPL NO | 17/288351 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/4545 (20130101) Original (OR) Class A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/32 (20130101) C07K 16/2833 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379047 | Makhov et al. |
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| FUNDED BY |
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| APPLICANT(S) | Institute For Cancer Research d/b/a The Research Institute Of Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Petr Makhov (Philadelphia, Pennsylvania); Vladimir Kolenko (Philadelphia, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions comprising a tyrosine kinase inhibitor and a farnesyltransferase inhibitor, or pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier, as well as methods for preventing or treating cancer by administering the same are disclosed herein. |
| FILED | Wednesday, October 30, 2019 |
| APPL NO | 17/288982 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/404 (20130101) A61K 31/4545 (20130101) Original (OR) Class A61K 31/4709 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379092 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | RHODE ISLAND HOSPITAL (Providence, Rhode Island); BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qian Chen (Barrington, Rhode Island); Yun Gao (Providence, Rhode Island); John M. Sedivy (Barrington, Rhode Island); Marco De Cecco (Pawtucket, Rhode Island) |
| ABSTRACT | Described herein is are compositions and methods for treating an articulating joint disorders, comprising systemically administering to a subject a nucleoside reverse transcriptase inhibitor (NRTI). |
| FILED | Monday, May 13, 2019 |
| APPL NO | 17/054409 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/675 (20130101) A61K 31/708 (20130101) Original (OR) Class A61K 31/7072 (20130101) A61K 31/7076 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379099 | ISAACS et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lyle David ISAACS (Silver Spring, Maryland); Steven MURKLI (College Park, Maryland) |
| ABSTRACT | Disclosed herein are water-soluble, cyclic cucurbit[n]uril, compositions containing the same, methods of preparation thereof, and uses thereof. These compounds are useful, for example, as sequestering agents for various agents, such as, for example, drugs of abuse. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335542 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/787 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379109 | Rabinowitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua D. Rabinowitz (Princeton, New Jersey); Roderick O'Connor (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention provides, in some embodiments, methods of promoting an immune response in a subject in need thereof, comprising administering to the subject a population of immune cells that express an enzyme that facilitates immune cell function in a nutrient-poor environment. The invention also provides, in other embodiments, compositions comprising an ex vivo population of immune cells expressing an enzyme that enhances immune cell function in a nutrient-poor environment. |
| FILED | Friday, August 23, 2019 |
| APPL NO | 17/270323 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/50 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379123 | Costa-Mattioli et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mauro Costa-Mattioli (Houston, Texas); Shelly Alexandra Buffington (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure concern methods and compositions related to manipulation of the microbiome in an individual having at least one social behavior deficit. In particular embodiments, an individual has at least one social behavior deficit and was born from a mother who during pregnancy was obese, overweight, or on a high-fat diet during pregnancy or carries mutations associated with neurodevelopmental disorders. In specific embodiments, the individual having at least one social behavior deficit is provided an effective amount of Lactobacillus reuteri for the improvement of at least one symptom of a social behavior deficit. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/445827 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1234 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/02 (20130101) A61K 9/20 (20130101) A61K 9/0053 (20130101) A61K 35/742 (20130101) Original (OR) Class A61K 35/747 (20130101) A61K 2035/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379141 | Ledford et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julie Ledford (Tucson, Arizona); Monica Kraft (Tucson, Arizona) |
| ABSTRACT | Provided herein are compositions and methods for treating and preventing lung disease. In particular, provided herein are SP-A peptides and uses thereof in the treatment and prevention of lung disease (e.g., asthma or COPD). |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/409642 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 38/08 (20130101) Original (OR) Class A61K 38/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379148 | Kinney et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University Of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Kinney (Marietta, Georgia); Robert J. Bloch (Baltimore, Maryland); John McLenithan (Baltimore, Maryland); Kaila Noland (Baltimore, Maryland); Andrea O'Neill (Towson, Maryland) |
| ABSTRACT | Transgenic mice (Crym tg) overexpressing Crym protein in skeletal muscle were studied. Muscular functions, Ca2+ transients, contractile force, fatigue, and running on treadmills or wheels were not significantly altered and serum T3 and thyroid stimulating hormone levels were unaffected although T3 levels in tibialis anterior (TA) muscle were elevated and serum T4 was decreased. Crym tg mice had a decreased respiratory exchange ratio, corresponding to a 13.7% increase in fat utilization. Female Crym tg mice gained weight more rapidly than controls on high fat or high simple carbohydrate diets. Machine learning algorithms revealed morphological differences between Crym tg and control soleus fibers. RNA-seq and gene ontology enrichment analysis showed a shift towards genes associated with slower muscle function and β-oxidation. Therefore, high levels of μ-crystallin are associated with greater fat metabolism. These data indicate that Crym and μ-crystallin can be used as a treatment modality for diabetes and obesity. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318767 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/11 (20130101) A61K 31/167 (20130101) A61K 31/203 (20130101) A61K 31/565 (20130101) A61K 31/568 (20130101) A61K 38/1709 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379152 | Dravid |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Creighton University (Omaha, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shashank Dravid (Omaha, Nebraska) |
| ABSTRACT | The disclosure provides polypeptides and pharmaceutical compositions thereof. Such polypeptides can be useful, for example, in treating pain in a subject. In some embodiments, the polypeptides are useful for treating neuropathic and/or inflammatory pain. |
| FILED | Wednesday, January 20, 2021 |
| APPL NO | 17/153165 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/191 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) A61P 25/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379168 | Hacohen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nir Hacohen (Brookline, Massachusetts); Catherine Ju-Ying Wu (Brookline, Massachusetts); Edward F. Fritsch (Concord, Massachusetts); Ute E. Burkhardt (Belmont, Massachusetts) |
| ABSTRACT | The present disclosure relates to methods for profiling subject specific and personalized T cell receptor (TCR) repertoires using a single-cell sequencing method. More particularly, disclosed are methods for determining binding of T cell receptors to subject specific neoantigens. In addition, the techniques herein may identify the antigenic targets of T cell receptors in the context of tumor neoantigens. Moreover, the present disclosure enables the discovery of T cell targets in numerous diseases, with implications for understanding the basic mechanisms of the mammalian immune response and for developing antigen-specific diagnostic markers and therapies. Finally, cloned TCRs can be used to formulate personalized immunotherapies for those inflicted with a disease, such as cancer. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217864 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 2039/515 (20130101) A61K 2039/572 (20130101) A61K 2039/5158 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1093 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) C12Q 2600/16 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379171 | Tuohy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent K. Tuohy (Broadview Heights, Ohio); Suparna Mazumder (Olmsted Falls, Ohio); Justin M. Johnson (Willoughby Hills, Ohio) |
| ABSTRACT | Provided herein are methods, kits and compositions for the treatment and/or prevention of ovarian cancer through the induction of an immune response against Anti-Mullerian Hormone Receptor, Type II (AMHR2). |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404025 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/138 (20130101) A61K 31/337 (20130101) A61K 31/502 (20130101) A61K 31/555 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/4196 (20130101) A61K 31/4745 (20130101) A61K 31/4985 (20130101) A61K 31/7048 (20130101) A61K 31/7064 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 33/244 (20190101) A61K 39/001102 (20180801) Original (OR) Class A61K 45/06 (20130101) A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379172 | Salem et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aliasger K. Salem (Coralville, Iowa); Emad I. Wafa (Iowa City, Iowa); Sean M. Geary (Iowa City, Iowa); Ned B. Bowden (Iowa City, Iowa); Jennifer H. Wilson-Welder (Boone, Iowa); David P. Alt (Nevada, Iowa) |
| ABSTRACT | A composition comprising particles formed of poly(diamidosulfide) and one or more leptospiral antigens, and methods of making and using the composition, are provided. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/119384 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1641 (20130101) A61K 39/0225 (20130101) Original (OR) Class A61K 2039/6093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379177 | HENDERSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rory HENDERSON (Durham, North Carolina); S. Munir ALAM (Durham, North Carolina); Barton F. HAYNES (Durham, North Carolina); Kevin J. WIEHE (Durham, North Carolina) |
| ABSTRACT | The technology is directed to HIV envelopes which comprise sequence modifications wherein these modifications prevent CD4-induced transitions of the HIV envelope. Specifically, the disclosure provides recombinant HIV-1 Env proteins comprising mutations, wherein the envelope is a protomer, and wherein three protomers form a trimer stabilized by the presence of the mutations. Provided also are compositions comprising envelopes of the technology, and methods of use. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 17/281918 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Peptides C07K 14/162 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/63 (20130101) C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379178 | SAUNDERS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin SAUNDERS (Durham, North Carolina); Barton F. HAYNES (Durham, North Carolina); Kevin J. WIEHE (Durham, North Carolina) |
| ABSTRACT | The invention is directed to modified HIV-1 envelopes, compositions comprising these modified envelopes, nucleic acids encoding these modified envelopes, compositions comprising these nucleic acids, and methods of using these modified HIV-1 envelopes and/or these nucleic acids to induce immune responses. |
| FILED | Wednesday, September 04, 2019 |
| APPL NO | 17/281933 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Peptides C07K 14/162 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/63 (20130101) C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379182 | Libraty |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel H. Libraty (Newton, Massachusetts) |
| ABSTRACT | The present invention relates to the construction of, and immunization with viral vaccines. In particular, bivalent vaccines that are capable of providing simultaneous virus infection protection for two or more different viruses. Furthermore, the bivalent vaccines contemplated herein are contemplated as being effective in a neonatal mammal. One such bivalent viral vaccine comprises two antigenic epitopes against the dengue viruses and at least one antigenic epitope against hepatitis B virus. Immunization cross-reactivity may also provide infection protection against other viruses as well. |
| FILED | Tuesday, May 01, 2018 |
| APPL NO | 16/612152 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/292 (20130101) A61K 39/295 (20130101) Original (OR) Class A61K 47/65 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) A61P 31/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379188 | Disney |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew D. Disney (Jupiter, Florida) |
| ABSTRACT | A method for the precise cellular destruction of an oncogenic non-coding RNA with a RNA-binding small molecule conjugated with bleomycin A5 is described. The method affords reversal of phenotype. Bleomycin A5 was coupled to an RNA-binding molecule that selectively binds the microRNA-96 hairpin precursor (pri-miR-96). By coupling of bleomycin A5's free amine to the RNA-binding molecule, its affinity for binding to pri-miR-96 is >100-fold stronger than to DNA. The conjugate compound selectively cleaves pri-miR-96 in triple negative breast cancer (TNBC) cells. Selective cleavage of pri-miR-96 enhances expression of FOXO1 protein, a pro-apoptotic transcription factor that miR-96 silences, and triggers apoptosis in TNBC cells. No effects were observed in healthy breast epithelial cells. This method provides programmable control for targeting RNA through the selection of an RNA-binding molecule/bleomycin A5 conjugate and provides a facile method of mapping the cellular binding sites of an RNA-binding molecule. |
| FILED | Thursday, September 26, 2019 |
| APPL NO | 17/284297 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) A61K 47/55 (20170801) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 2310/141 (20130101) C12N 2320/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379190 | Bachovchin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William W. Bachovchin (Cambridge, Massachusetts); Hung-sen Lai (Andover, Massachusetts); Sarah E. Poplawski (Belmont, Massachusetts) |
| ABSTRACT | Disclosed are proteasome inhibitors, fibroblast activation protein (FAP)-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also disclosed are related pharmaceutical compositions, and methods of using the inhibitors and prodrugs and compositions thereof, for example, in treating cancer or other cell proliferative diseases. In vitro and in vivo methods of quantifying the expression of FAP in a biopsy sample and a mammal, respectively, are also disclosed. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348043 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) A61K 38/00 (20130101) A61K 38/07 (20130101) A61K 45/06 (20130101) A61K 47/54 (20170801) A61K 47/64 (20170801) Original (OR) Class Peptides C07K 5/081 (20130101) C07K 5/0806 (20130101) C07K 5/0808 (20130101) C07K 5/0812 (20130101) C07K 5/0821 (20130101) C07K 5/1016 (20130101) C07K 5/06026 (20130101) C07K 5/06034 (20130101) C07K 5/06078 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379191 | Bayir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hulya Bayir (Pittsburgh, Pennsylvania); Peter Wipf (Pittsburgh, Pennsylvania); Tanja Krainz (Pittsburgh, Pennsylvania); Robert Clark (Pittsburgh, Pennsylvania) |
| ABSTRACT | A mitochondrial-targeted PARP inhibitor is provided herein, as well as methods of making and using the mitochondrial-targeted PARP inhibitor. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403182 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4184 (20130101) A61K 45/06 (20130101) A61K 47/64 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379201 | Adler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric D. Adler (La Jolla, California); Bradley Nelson (La Jolla, California); Sherin Hashem (La Jolla, California) |
| ABSTRACT | This disclosure provides gene therapy vectors comprising a polynucleotide encoding one or more isoforms of lysosome-associated membrane protein 2 (LAMP-2), and methods of using such gene therapy vectors for the treatment of Danon disease and other autophagy disorders. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/351113 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 2217/075 (20130101) A01K 2227/105 (20130101) A01K 2267/0306 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 48/005 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) A61P 9/00 (20180101) Peptides C07K 14/70596 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/8645 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379208 | Jasanoff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Alan Pradip Jasanoff (Cambridge, Massachusetts); He Wei (Arlington, Massachusetts) |
| ABSTRACT | The present disclosure generally relates in certain embodiments to a magnetic imaging kit for biochemical sensing, e.g., for detection of analytes, via magnetic imaging techniques. For instance, in one set of embodiments, the kit comprises a collection of magnetic imaging agents (e.g. superparamagnetic iron oxide nanoparticles) and linker species (e.g. a catechol, phosphothreonine, and/or derivative thereof) with a molecular weight of less than or equal to 1000 Da, or less than or equal to 500 Da. The magnetic imaging agents may sense the presence of an analyte via aggregation or disaggregation of the two or more magnetic imaging agents. In addition, certain aspects are directed to a method of exposing two or more magnetic imaging agents to a region on or in a subject and imaging the region to determine the analyte. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224492 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/1833 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379245 | Christman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karen Christman (San Diego, California); Martin Spang (San Diego, California); Gregory Grover (La Jolla, California) |
| ABSTRACT | Compositions and methods for their manufacture and use are provided comprising a soluble extracellular matrix fraction for intravascular delivery which forms a gel or coating in situ for treatment of myocardial infarction and ischemia in a variety of tissues and endothelial injury/dysfunction. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 17/286534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/014 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 27/3633 (20130101) Original (OR) Class A61L 27/3683 (20130101) A61L 2400/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379356 | Criscione et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); CORINNOVA INCORPORATED (Houston, Texas) |
| ASSIGNEE(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); CORINNOVA INCORPORATED (Houston, Texas) |
| INVENTOR(S) | John C. Criscione (College Station, Texas); Lewis D. Harrison (Flower Mound, Texas); Michael R. Moreno (College Station, Texas); Christina M. Bolch (Houston, Texas); Dennis I. Robbins (Richardson, Texas); Saurabh Biswas (College Station, Texas); Boris Leschinsky (Mahwah, New Jersey) |
| ABSTRACT | The present invention provides a direct cardiac compression device for individualized support at different locations around the heart, the device comprising: a housing shaped to conform to the shape of the heart and to surround the heart; two or more active chambers positioned adjacent to the housing, wherein the two or more active comprise one or more right active chambers positioned on the right ventricle side of the heart and one or more left active chambers positioned on the left ventricle side of the heart, wherein the two or more active chambers are designed to conform to the shape of the heart, each active chamber comprising an inner membrane sealingly attached along its periphery to the housing and an active fluid individually supplied thereto; a right input connection in fluid communication with the one or more right active chambers to ingress the active fluid into each of the one or more right active chambers; a left input connection in fluid communication with the one or more left active chambers to ingress the active fluid into each of the one or more left active chambers, and a driver in fluid communication with each of the right input connection and the left input connection to individually and periodically ingress and egress the active fluid therefrom, wherein the active fluid individually inflates the one or more right active chambers and the one or more left active chambers to compress the heart. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 17/395052 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2481 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/148 (20210101) A61M 60/268 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379545 | Costa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonio P. Costa (Farmington, Connecticut); Diane J. Burgess (Farmington, Connecticut) |
| ABSTRACT | The present disclosure provides a system for the internal and external modification of nanoparticles in a continuous process. The system includes (a) a first inlet, (b) a second inlet, (c) a first pump in fluid communication with the first inlet, (d) a second pump in fluid communication with the second inlet, (e) a first flow meter positioned between the first pump and the first mixer, (f) a second flow meter positioned between the second pump and the first mixer, and (g) a mixing chamber in fluid communication with the first flow meter and the second flow meter, and (h) a first heat exchanger in fluid communication with the mixing chamber. |
| FILED | Monday, October 28, 2019 |
| APPL NO | 17/286956 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 9/1278 (20130101) Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 5/0646 (20130101) B01F 13/0079 (20130101) Original (OR) Class B01F 15/00136 (20130101) B01F 15/0243 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379555 | Weitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Vilnius University (Vilnius, Lithuania) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Vilnius University (Vilnius, Lithuania) |
| INVENTOR(S) | David A. Weitz (Cambridge, Massachusetts); Allon Moshe Klein (Cambridge, Massachusetts); Ilke Akartuna (Cambridge, Massachusetts); Linas Mazutis (Vilnius, Lithuania); Marc W. Kirschner (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/323902 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 13/0062 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Original (OR) Class B01J 2219/00585 (20130101) B01J 2219/00722 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 3/502776 (20130101) B01L 3/502784 (20130101) B01L 7/52 (20130101) B01L 2200/0652 (20130101) B01L 2300/0883 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379589 | Konstantopoulos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); University of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Konstantinos Konstantopoulos (Ellicott City, Maryland); Collin Dowlin Paul (Catonsville, Maryland); Alfredo Quinones-Hinojosa (Bel Air, Maryland); Alkaterini Kontrogianni-Konstantopoulos (Ellicott City, Maryland) |
| ABSTRACT | The present invention describes an integrated apparatus that enables identification of migratory cells directly from a specimen. The apparatus only requires a small number of cells to perform an assay and includes novel topographic features which can reliably differentiate between migratory and non-migratory cell populations in a sample. Both the spontaneous and chemotactic migration of cancer cells may be measured to distinguish between subpopulations within a tumor sample. The migratory cells identified using the apparatus and methods of the present invention may be separated and further analyzed to distinguish factors promoting metastasis within the population. Cells in the apparatus can be treated with chemotherapeutic or other agents to determine drug strategies to most strongly inhibit migration. The use of optically transparent materials in some embodiments allows a wide range of imaging techniques to be used for in situ imaging of migratory and non migratory cells in the apparatus. The apparatus and methods of the present invention are useful for predicting the metastatic propensity of tumor cells and selecting optimal drugs for personalized therapies. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405409 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2200/10 (20130101) B01L 2200/027 (20130101) B01L 2200/0652 (20130101) B01L 2200/0689 (20130101) B01L 2300/12 (20130101) B01L 2300/041 (20130101) B01L 2300/0816 (20130101) B01L 2300/0861 (20130101) B01L 2300/0864 (20130101) B01L 2300/0887 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5029 (20130101) G01N 33/5091 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380420 | Handa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hitesh Handa (Athens, Georgia); Marcus Goudie (Athens, Georgia); Jitendra Pant (Athens, Georgia); Bryan Grommersch (Alpharetta, Georgia); Sean Hopkins (Athens, Georgia) |
| ABSTRACT | Nitric oxide-releasing materials, methods of making nitric oxide-releasing materials, and uses of nitric oxide-releasing materials are provided. The nitric oxide-releasing materials include a mesoporous silica core and an outer surface having a plurality of nitric oxide donors. In an exemplary aspects, the nitric oxide-releasing material includes a mesoporous diatomaceous earth core, and an outer surface having a plurality of S-nitroso-N-acetyl-penicillamine groups covalently attached thereto. Uses of the nitric oxide-releasing materials can include coatings for medical devices such as catheters, grafts, and stents; wound gauzes; acne medications; and antiseptic mouthwashes; among others. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399634 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/28 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/306 (20130101) A61L 27/3637 (20130101) A61L 29/08 (20130101) A61L 29/16 (20130101) A61L 29/106 (20130101) A61L 29/146 (20130101) A61L 31/08 (20130101) A61L 31/16 (20130101) A61L 31/088 (20130101) A61L 31/146 (20130101) A61L 2300/114 (20130101) A61L 2420/04 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/149 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/82 (20130101) C01P 2004/03 (20130101) C01P 2004/61 (20130101) C01P 2006/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380531 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhttan, Kansas); Wichita State University (Wichita, Kansas); University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyeong-Ok Chang (Manhttan, Kansas); Yunjeong Kim (Manhattan, Kansas); William C. Groutas (Wichita, Kansas); Stanley Perlman (Iowa City, Iowa) |
| ABSTRACT | Compounds and treatment methods with compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: or a prodrug or pharmaceutically-acceptable salt thereof, where: each X comprises at least one cyclic moiety directly attached to the oxygen or connected via an alkyl linkage, where at least one of the linkage and/or the X moiety comprises a deuterium substitution; and Z is selected from the group consisting of aldehydes and bisulfite salts, or the ester or carbamate prodrugs thereof. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343334 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Heterocyclic Compounds C07D 207/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380546 | Carson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis Carson (La Jolla, California); Mary Patricia Corr (San Diego, California); Howard B. Cottam (Escondido, California); Tomoko Hayashi (San Diego, California); Nikunj Shukla (San Diego, California) |
| ABSTRACT | Compounds useful as an adjuvant, e.g., formulas (I)-(VI) and uses thereof, for example, with immunogenic moieties or other adjuvants, are provided. |
| FILED | Tuesday, October 22, 2019 |
| APPL NO | 17/287914 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 2039/55511 (20130101) Heterocyclic Compounds C07D 277/44 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380559 | Acker et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy M. Acker (San Francisco, California); Dennis C. Liotta (Atlanta, Georgia); Stephen F. Traynelis (Decatur, Georgia); Yao Jing (Dunwoody, Georgia) |
| ABSTRACT | This disclosure relates to pyrazoline dihydroquinolone derivatives, pharmaceutical compositions, and uses. In certain embodiments, the compounds are selective NMDA receptor inhibitors and are useful in therapeutic methods related thereto. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a compound of the following formula: or salts, esters, or prodrugs thereof, as provided herein. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404579 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/497 (20130101) A61K 31/4709 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 401/04 (20130101) C07D 401/14 (20130101) Original (OR) Class Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380615 | ROSEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BARRY P. ROSEN (BOYNTON BEACH, Florida); STANISLAW F. WNUK (MIAMI, Florida); MASAFUMI YOSHINAGA (DORAL, Florida); MD ABU HASAN HOWLADER (MIAMI, Florida); SK MD SAZZAD HOSSAIN SUZOL (PHILADELPHIA, Pennsylvania) |
| ASSIGNEE(S) | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (MIAMI, Florida) |
| INVENTOR(S) | BARRY P. ROSEN (BOYNTON BEACH, Florida); STANISLAW F. WNUK (MIAMI, Florida); MASAFUMI YOSHINAGA (DORAL, Florida); MD ABU HASAN HOWLADER (MIAMI, Florida); SK MD SAZZAD HOSSAIN SUZOL (PHILADELPHIA, Pennsylvania) |
| ABSTRACT | The subject invention provides methods and procedures for synthesis and/or semi-synthesis of the novel antibiotic arsinothricin (AST) and derivatives. Arsinothricin (AST), a new broad-spectrum organoarsenical antibiotic, is a non-proteinogenic analog of glutamate that effectively inhibits glutamine synthetase. The subject invention provides chemical synthesis of an intermediate in the pathway of AST synthesis, hydroxyarsinothricin (AST-OH), which can be converted to AST by enzymatic methylation catalyzed by the ArsM As(III) S-adenosylmethionine methyltransferase. The methods provide a source of the novel antibiotic that will be required for future clinical trials. The subject invention also provides AST derivatives as a new class of antibiotics. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186538 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/72 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380635 | Thayumanavan et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sankaran Thayumanavan (Amherst, Massachusetts); Richard W. Vachet (Belchertown, Massachusetts); Jiaming Zhuang (Amherst, Massachusetts); Bo Zhao (Sunderland, Massachusetts) |
| ABSTRACT | The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, delivery, probing and/or analytical measurements of small molecule drugs, proteins, antibodies and other biomolecules. The invention provides novel biologically active agents useful as diagnostics or therapeutics, and related composition and methods of uses thereof. |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/254433 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/54 (20170801) A61K 47/6803 (20170801) Acyclic or Carbocyclic Compounds C07C 69/593 (20130101) C07C 229/30 (20130101) C07C 229/34 (20130101) C07C 235/28 (20130101) C07C 271/28 (20130101) C07C 311/53 (20130101) C07C 323/54 (20130101) Heterocyclic Compounds C07D 213/20 (20130101) C07D 213/74 (20130101) Peptides C07K 1/13 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380644 | HOFT et al. |
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| FUNDED BY |
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| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); EpiVax, Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Saint Louis University (St. Louis, Missouri); EpiVax, Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Daniel F. HOFT (St. Louis, Missouri); Christopher S. EICKHOFF (St. Louis, Missouri); Annie DE GROOT (Providence, Rhode Island) |
| ABSTRACT | The present invention provides compositions and methods for generation of an anti-influenza immune response. In particular, conserved T cell epitopes within matrix protein and nucleoprotein components of influenza virus have been identified and further screened for those structures that will bind either or both of HLA I and II molecules. Methods for vaccinating subjects with formulations of such peptides for the treatment or prevention of influenza infection also are described. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 17/288133 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 39/39 (20130101) A61K 39/145 (20130101) Peptides C07K 14/11 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380650 | OLSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Eric N. OLSON (University Park, Texas); Rhonda S. BASSEL-DUBY (Dallas, Texas); Catherine A. MAKAREWICH (Dallas, Texas); Benjamin R. NELSON (Dallas, Texas) |
| ABSTRACT | The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/392137 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 45/06 (20130101) A61K 48/0058 (20130101) Peptides C07K 14/47 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380652 | Schlom et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Jeffrey Schlom (Potomac, Maryland); Claudia M. Palena (Potomac, Maryland) |
| ABSTRACT | The invention provides Brachyury deletion mutant polypeptides, nucleic acids encoding the polypeptides, non-yeast vectors comprising the nucleic acids, non-yeast cells, and methods of use. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/346452 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 38/193 (20130101) A61K 38/1709 (20130101) A61K 39/0011 (20130101) A61K 39/00117 (20180801) A61K 39/001152 (20180801) A61K 39/001182 (20180801) A61K 45/06 (20130101) A61K 2039/70 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4702 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/10043 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380653 | Sokoloff et al. |
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| FUNDED BY |
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| APPLICANT(S) | Theraly Fibrosis, Inc. (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alex Sokoloff (Madison, Wisconsin); Viktor Roschke (Bethesda, Maryland); Kang Choon Lee (Seoul, South Korea); Seulki Lee (Ellicott City, Maryland); Yumin Oh (Clarksville, Maryland) |
| ABSTRACT | Fusion polypeptides with modified multimerization domains that provide high expression, solubility, stability, and low immunogenicity to the fusion polypeptides have been developed. TRAIL compositions with the modified multimerization domains show improved physico-chemical and biological properties relative to TRAIL compositions with unmodified multimerization domains. The TRAIL compositions also have lower immunogenicity in the mammalian host when compared to that of TRAIL compositions with unmodified multimerization domains. The TRAIL compositions induce apoptosis of cancer cells and cancer-associated fibroblasts in vivo, reducing tumor size. |
| FILED | Tuesday, April 06, 2021 |
| APPL NO | 17/223283 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) A61K 47/65 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4703 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380660 | Meza-Romero et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Roberto Meza-Romero (Beaverton, Oregon); Arthur A. Vandenbark (Portland, Oregon); Halina Offner (Portland, Oregon) |
| ABSTRACT | Recombinant polypeptides comprising a modified DRα1 domain are provided. In some embodiments, the polypeptides include the modified DRα1 domain, an antigenic peptide, and optionally a linker sequence. Pharmaceutical compositions comprising the recombinant polypeptides, methods of treating inflammatory disease using said recombinant polypeptides or pharmaceutical compositions, and expression constructs comprising nucleic acids that encode the recombinant polypeptides are also provided. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282455 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0008 (20130101) A61K 2039/6031 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 14/70539 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380661 | Lowe et al. |
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| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Devin B. Lowe (Abilene, Texas); Amanda L. Wooster (Abilene, Texas) |
| ABSTRACT | The present invention includes compositions and methods of making and using a fusion protein comprising a peptide, a first flexible linker, a β2-microglobulin domain, a second flexible linker, a soluble major histocompatibility complex (MHC) heavy chain and a peptide tag. |
| FILED | Tuesday, October 15, 2019 |
| APPL NO | 17/284525 |
| CURRENT CPC | Peptides C07K 14/70539 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2319/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380665 | Hla et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Timothy T. Hla (Wellesley, Massachusetts); Steven L. Swendeman (Cambridge, Massachusetts); Mark Puder (Medfield, Massachusetts); Lois Smith (West Newton, Massachusetts) |
| ABSTRACT | Provided herein are methods of treating lung disease using fusion proteins comprising ApoM (e.g., human or murine ApoM) fused to a constant region (Fc) of a immunoglobulin G (IgG, e.g., human IgG or murine IgG). |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/284299 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 14/775 (20130101) Original (OR) Class C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380666 | Rose et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Jason J. Rose (Pittsburgh, Pennsylvania); Jesus Tejero Bravo (Pittsburgh, Pennsylvania); Kazi R. Islam (Cheswick, Pennsylvania); Mark T. Gladwin (Pittsburgh, Pennsylvania); Raymond B. Yurko (McMurray, Pennsylvania); Anthony W. DeMartino (Pittsburgh, Pennsylvania) |
| ABSTRACT | Synthetic heme-containing molecules are described. The heme-containing molecules include a heme group bound to either two non-contiguous peptides or a single contiguous peptide via cysteine residues. Use of the synthetic heme-containing molecules, such as for the treatment of carboxyhemoglobinemia, cyanide poisoning and hydrogen sulfide (H2S) poisoning, is further described. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/410819 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/00 (20130101) Peptides C07K 14/805 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380668 | WINGFIELD et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT, OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul T. WINGFIELD (Bethesda, Maryland); Norman R. WATTS (Bethesda, Maryland); Alasdair C. STEVEN (Bethesda, Maryland) |
| ABSTRACT | Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Hepatitis B Virus infection in mammals, and to methods of using those compositions of matter for the same. |
| FILED | Thursday, July 19, 2018 |
| APPL NO | 16/631290 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/6839 (20170801) A61K 2039/585 (20130101) Peptides C07K 16/082 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/55 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56994 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380671 | Brouxhon et al. |
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| FUNDED BY |
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| APPLICANT(S) | Sabine Brouxhon (Stony Brook, New York); M. Kerry O'Banion (Pittsford, New York); Stephanos Kyrkanides (Stony Brook, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sabine Brouxhon (Stony Brook, New York); M. Kerry O'Banion (Pittsford, New York); Stephanos Kyrkanides (Stony Brook, New York) |
| ABSTRACT | The present invention is based, in part, on our discovery that targeting epitopes within one or more of the EC2-EC5 subdomains of E-cadherin results in the death of epithelial-derived tumor cells but not in the death of normal, healthy epithelial cells or non-epithelial cells including endothelial cells and fibroblasts. Accordingly, the compositions of the invention include polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin and biologically active variants thereof, expression vectors and cells for expressing such polypeptides; and agents (e.g., antibodies) that target the EC2-EC5 subdomains. The methods of the invention include methods of identifying and producing polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin or a biologically active variant thereof; methods of generating agents, such as antibodies, that target these polypeptides; and methods of administering such agents or eliciting their production in vivo to treat epithelial cancers or reduce the risk of their occurrence or recurrence. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406611 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/395 (20130101) A61K 39/001166 (20180801) A61K 39/39558 (20130101) A61K 45/00 (20130101) A61K 45/06 (20130101) A61K 51/1093 (20130101) A61K 2039/505 (20130101) Peptides C07K 14/47 (20130101) C07K 16/18 (20130101) Original (OR) Class C07K 16/2896 (20130101) C07K 2317/73 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/57488 (20130101) G01N 2333/4704 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380683 | CHEN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE METHODIST HOSPITAL SYSTEM (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenhao CHEN (Houston, Texas); Xian Chang LI (Houston, Texas) |
| ABSTRACT | Disclosed are methods and compositions for inhibiting IRF4 in T-cells, thereby improving transplant outcomes or treating an autoimmune disease such as a myelination disorder. Thus, disclosed are methods to improve a transplant outcome in a recipient of a transplant comprising inhibiting IRF4 in T-cells of the recipient, thereby improving the transplant outcome. In some embodiments, IRF4 can be inhibited by administering an IRF4 inhibitor (e.g., trametinib or anti-IRF4 siRNA), and/or by adoptive transfer of T-cells having IRF4 inhibition. In some embodiments, the T-cells are CD4+ Tcells, and the infiltration thereof into a transplant can be reduced. Also disclosed are methods of treating a subject with a myelination disorder (e.g., multiple sclerosis or encephalomyelitis) comprising inhibiting IRF4. |
| FILED | Friday, April 12, 2019 |
| APPL NO | 17/046843 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 16/2803 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380941 | Lee et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frances Eun-Hyung Lee (Atlanta, Georgia); Ignacio Sanz (Atlanta, Georgia); Doan Nguyen (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to growth media and environments for in vitro culturing of cells that produce or are capable of producing antibodies. In certain embodiments, the media comprises IL-6, fibronectin, and typically a saccharide. In certain embodiments, the disclosure contemplates cell culture compositions comprising IL-6 and fibronectin that are derived from proteins secreted from mesenchymal stromal/stem cells (MSCs). In certain embodiments, the disclosure contemplates enclosures comprising culture compositions disclosed herein that are in ambient air or optionally in an environment wherein oxygen is absent or at a low concentration. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406212 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) Original (OR) Class C12N 2500/02 (20130101) C12N 2501/24 (20130101) C12N 2501/25 (20130101) C12N 2501/998 (20130101) C12N 2501/2306 (20130101) C12N 2501/2321 (20130101) C12N 2533/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380943 | BOLLARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S NATIONAL MEDICAL CENTER (Washington, District of Columbia) |
| ASSIGNEE(S) | CHILDREN'S NATIONAL MEDICAL CENTER (Washington, District of Columbia) |
| INVENTOR(S) | Catherine BOLLARD (Washington, District of Columbia); Conrad CRUZ (Washington, District of Columbia); Patrick HANLEY (Washington, District of Columbia) |
| ABSTRACT | Safe, rapid, and efficient methods for producing antigen-specific T cells recognizing human papilloma virus (HPV antigens); HPV-specific T cells, and methods for treating HPV infections and HPV-related malignancies by adoptive transfer of HPV-specific T cells. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404105 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/00 (20130101) A61K 39/295 (20130101) A61K 2039/5158 (20130101) Peptides C07K 14/55 (20130101) C07K 14/075 (20130101) C07K 14/535 (20130101) C07K 14/5406 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 2501/51 (20130101) C12N 2501/59 (20130101) C12N 2501/2307 (20130101) C12N 2501/2315 (20130101) C12N 2502/1121 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380947 | Slukvin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor Slukvin (Verona, Wisconsin); Akhilesh Kumar (Madison, Wisconsin) |
| ABSTRACT | The present invention relates generally to methods and compositions useful for therapeutic vascular tissue engineering. In particular, the present invention provides methods for generating substantially pure populations of vasculogenic cells from human mesenchymal progenitors, and methods and compositions for clinical applications in the field of regenerative medicine. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403202 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/34 (20130101) A61K 35/44 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0661 (20130101) Original (OR) Class C12N 2500/90 (20130101) C12N 2501/15 (20130101) C12N 2501/135 (20130101) C12N 2501/999 (20130101) C12N 2506/1346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380952 | Koyuncu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emre Koyuncu (Princeton, New Jersey); Ileana M. Cristea (Princeton, New Jersey); Thomas Shenk (Princeton, New Jersey) |
| ABSTRACT | A method is provided to improve virus production is an infected host cell by culturing the infected cell in an effective amount of alpha-ketoglutarate. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381930 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0018 (20130101) C12N 7/00 (20130101) Original (OR) Class C12N 2500/36 (20130101) C12N 2501/999 (20130101) C12N 2710/16151 (20130101) C12N 2710/16751 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380962 | STONE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Everett STONE (Austin, Texas); Wei-Cheng LU (Austin, Texas); Christos KARAMITROS (Austin, Texas) |
| ABSTRACT | Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, disclosed are modified cystathionine-γ-lyases comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, compositions and methods are provided for the treatment of cystinuria using the disclosed modified enzymes or nucleic acids encoding said enzymes. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 17/288151 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/225 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) A61K 47/60 (20170801) Peptides C07K 2319/30 (20130101) C07K 2319/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Original (OR) Class Enzymes C12Y 404/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380967 | Knutson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven D. Knutson (Atlanta, Georgia); Jennifer M. Heemstra (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to improved methods of identifying A-to-I RNA edits in a sample. In certain embodiments, this disclosure relates to methods of purifying RNA containing an inosine base comprising the steps of: exposing an RNA sample to endonuclease V or fusion thereof and calcium ions in the absence of magnesium ions providing an RNA and endonuclease V binding complex. In certain embodiments, the methods further comprise purifying the RNA and endonuclease V binding complex from unbound RNA in the sample; separating the RNA from endonuclease V providing separated RNA; sequencing the separated RNA; and identifying positions in the RNA sequences wherein A-to-I edits occur. In certain embodiments, the RNA is derived from a cell. |
| FILED | Thursday, January 23, 2020 |
| APPL NO | 17/425698 |
| CURRENT CPC | Peptides C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/1013 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Enzymes C12Y 301/21007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380972 | Adey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Illumina, Inc. (San Diego, California); Illumina Cambridge Limited (Cambridge, United Kingdom); Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | Illumina, Inc. (San Diego, California); Illumina Cambridge Limited (Cambridge, United Kingdom); Oregon Health and Science University (Portland, Oregon) |
| INVENTOR(S) | Andrew C. Adey (Portland, Oregon); Ryan Mulqueen (Portland, Oregon); Frank Steemers (San Diego, California); Dmitry K Pokholok (San Diego, California); Fan Zhang (San Diego, California); Esther Musgrave-Brown (Cambridge, United Kingdom) |
| ABSTRACT | The present disclosure is concerned with compositions, methods, and kits for preparing a sequencing library. In one embodiment, methods include producing a library of target nucleic acids having the same adapter at each end and then switching the identity of one adapter to result in target nucleic acids flanked by distinct adapters. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344030 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1068 (20130101) Original (OR) Class C12N 15/1072 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6855 (20130101) C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380977 | CHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ching-Pin CHANG (Indianapolis, Indiana); Wei Cheng (Indianapolis, Indiana) |
| ABSTRACT | Disclosed are methods of detecting myocardial enhancer RNA levels in mammalian cardiomyocytes. In a further embodiment, a method of disrupting assembly of an enhancer DNA-Myh6 promoter-Myh7 promoter complex, is provided wherein the method comprises providing enhancer RNA to a cardiomyocyte. |
| FILED | Friday, October 18, 2019 |
| APPL NO | 17/283845 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380978 | Mineo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marco Mineo (Brighton, Massachusetts); E. Antonio Chiocca (Wakefield, Massachusetts) |
| ABSTRACT | Compositions comprising inhibitory nucleic acids targeting the long non-coding RNA INCA1, and methods of use thereof, e.g., in combination with immunotherapy, to treat cancer. |
| FILED | Tuesday, October 15, 2019 |
| APPL NO | 17/284919 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/315 (20130101) C12N 2310/3181 (20130101) C12N 2310/3231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380981 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Guangping Gao (Westborough, Massachusetts); Yi Lu (Shanghai, China PRC); Qiang Zheng (Chengdu, China PRC); Xun Xu (Shanghai, China PRC); Phillip D. Zamore (Northborough, Massachusetts); Phillip Tai (Worcester, Massachusetts) |
| ABSTRACT | The disclosure relates, in some aspects, to compositions and methods for treating corneal disease (e.g., corneal neovascularization. In some embodiments, the disclosure relates to rAAV-mediated delivery of an cornea-associated transgene to a subject. In some embodiments, the rAAV transduces the corneal tissue of a subject. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/342587 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2310/141 (20130101) C12N 2320/32 (20130101) C12N 2330/51 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380988 | Mercurio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arthur M. Mercurio (Boston, Massachusetts); Caitlin Westberg Brown (Northborough, Massachusetts) |
| ABSTRACT | Compositions and methods for inducing tumor cell death by inhibiting prominin2 (PROM2) or heat shock factor protein 1 (HSF1), optionally in combination with an agent that promotes ferroptosis, preferably an inhibitor of glutathione peroxidase 4 (GPX4), e.g., to trigger ferroptosis in the tumor cells. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319473 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/15 (20130101) A61K 31/437 (20130101) A61K 31/496 (20130101) A61K 31/517 (20130101) A61K 31/4439 (20130101) A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1137 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380990 | KIANI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samira KIANI (Scottsdale, Arizona); Mo Reza EBRAHIMKHANI (Scottsdale, Arizona); Farzaneh MOGHADAM (Tempe, Arizona) |
| ABSTRACT | Provided herein are CRISPR-based synthetic repression systems as well as methods and compositions using the synthetic repression systems to treat septicemia, an adverse immune response in a subject and Waldanstrom macroglobulinemia. |
| FILED | Thursday, November 07, 2019 |
| APPL NO | 17/292407 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0008 (20130101) Peptides C07K 14/4703 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) C12N 2830/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381004 | Esteves |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miguel Sena Esteves (Westford, Massachusetts) |
| ABSTRACT | Aspects of the disclosure relate to compositions and methods for the treatment of lysosomal storage disorders, such as GM1 gangliosidosis, Tay Sachs disease, and Sandhoff disease. In some embodiments, the compositions comprise viral vectors encoding beta-galactosidase. In some embodiments, the compositions comprise viral vectors encoding beta-hexosaminidase subunits (e.g. HEXA, HEXB, or combinations thereof). |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282421 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2830/42 (20130101) Enzymes C12Y 302/01052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381015 | Ernst et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); University of Washington through its Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert K. Ernst (Silver Spring, Maryland); Mark Pelletier (Brunswick, Maryland); Adeline Hajjar (Seattle, Washington) |
| ABSTRACT | Embodiments of the disclosure provide for unique lipooligosaccharide/lipid A-based mimetics for use as adjuvants. Methods of generating lipooligosaccharide/lipid A-based mimetics are provided that utilize recombinantly engineered bacteria to produce the mimetics, including, for example, addition of one or more particular enzymes such as acyltransferases, deacylases, phosphatases, or glycosyltransferases. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/445708 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/739 (20130101) A61K 39/39 (20130101) A61K 39/099 (20130101) A61K 39/0291 (20130101) A61K 2039/55572 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 11/04 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/12 (20130101) Original (OR) Class C12P 19/26 (20130101) C12P 19/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381043 | Ju et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Jingyue Ju (Englewood Cliffs, New Jersey); Dae Hyun Kim (Northbrook, Illinois); Lanrong Bi (Hancock, Michigan); Qinglin Meng (Foster City, California); Xiaoxu Li (New York, New York) |
| ABSTRACT | This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405341 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381045 | Xie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoliang Sunney Xie (Lexington, Massachusetts); Katsuyuki Shiroguchi (Arlington, Massachusetts); Peter A. Sims (Cambridge, Massachusetts); Tony Z. Jia (Cambridge, Massachusetts) |
| ABSTRACT | Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/410415 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6853 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381048 | SALK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse SALK (Seattle, Washington); Lawrence A. LOEB (Bellevue, Washington); Michael SCHMITT (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/392207 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381049 | Daugharthy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan R. Daugharthy (Cambridge, Massachusetts); George M. Church (Brookline, Massachusetts) |
| ABSTRACT | The disclosure provides a method for detecting a target analyte in a biological sample including contacting the sample with one or more probe sets each comprising a primary probe and a linker, contacting the sample with an initiator sequence, contacting the sample with a plurality of fluorescent DNA hairpins, wherein the probe binds the target molecule, the linker connects the probe to the initiator sequence, and wherein the initiator sequence nucleates with the cognate hairpin and triggers self-assembly of tethered fluorescent amplification polymers, and detecting the target molecule by measuring fluorescent signal of the sample. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392325 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) C12N 2310/16 (20130101) C12N 2320/10 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6806 (20130101) C12Q 1/6816 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381051 | Horvath |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Stefan Horvath (Los Angeles, California) |
| ABSTRACT | DNA methylation (DNAm) based biomarkers of aging have been developed for many tissues and organs. However, these biomarkers have sub-optimal accuracy in skin cells, fibroblasts and other cell types that are often used in ex vivo studies. To address this challenge, we analyzed DNA methylation array data sets derived from multiple sources of DNA, from which we developed a novel and highly robust DNAm age estimator (based on 391 CpGs) for human fibroblasts, keratinocytes, buccal cells, endothelial cells, lymphoblastoid cells, skin, blood, and saliva samples. The application of this new age estimator to ex vivo cell culture systems revealed that cellular population doubling is generally accompanied by an increase in epigenetic aging. The new skin & blood clock disclosed herein is useful for ex vivo and in vivo studies of human aging. |
| FILED | Friday, May 31, 2019 |
| APPL NO | 17/058542 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381057 | HU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); WINDBER RESEARCH INSTITUTE (Windber, Pennsylvania); THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPT OF HEALTH AND HUMAN SERVICE (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hai HU (Windber, Pennsylvania); Yi ZHANG (San Diego, California); Albert KOVATICH (Bethesda, Maryland); Maxwell LEE (Bethesda, Maryland); Craig D. SHRIVER (Bethesda, Maryland) |
| ABSTRACT | The present disclosure provides gene expression profiles that are associated with cancer, including certain gene expression profiles that differentiate between cancer that is at a high risk of recurrence. The gene expression profiles can be measured at the nucleic acid or protein level. The gene expression profiles can also be used to identify a subject for cancer treatment. Also provided are kits for use in predicting cancer recurrence and/or prognosing cancer and an array comprising probes for detecting the unique gene expression profiles associated with cancer. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 17/273014 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381061 | Mulé et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James J. Mulé (Odessa, Florida); Domenico Coppola (Tampa, Florida); Timothy J. Yeatman (Thonotosassa, Florida); Audrey Loboda (Philadelphia, Pennsylvania); Michael V. Nebozhyn (Yeadon, Pennsylvania) |
| ABSTRACT | This invention relates to methods for selecting a treatment, treating, and predicting survival time in subjects with cancer, such as colorectal cancer, based on tumor expression levels of chemokines, cytotoxic genes, and/or dendritic cell genes. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/330177 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/57407 (20130101) G01N 33/57415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381062 | Spira et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Avrum Spira (Newton, Massachusetts); Marc E. Lenburg (Brookline, Massachusetts); Joseph Perez-Rogers (San Mateo, California); Christina Anderlind (Newton, Massachusetts) |
| ABSTRACT | This application provides assays and methods for diagnosis and prognosis of lung cancer using expression analysis of one or more genes from a biological sample comprising nasal epithelial cells. The assays and methods are non-invasive and accurately detect the presence or absence of lung cancer relative to, for example, more invasive techniques, such as bronchoscopy. Similarly, the assays and methods described provide non-invasive ways of accurately identifying the smoking history of a subject. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397905 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381129 | Kaplan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Fiorenzo G. Omenetto (Lexington, Massachusetts); Chunmei Li (Stoneham, Massachusetts); Chengchen Guo (Wakefield, Massachusetts) |
| ABSTRACT | In some embodiments, the present disclosure provides methods including the steps of (i) providing silk fibroin material comprising substantially amorphous structure, and (ii) applying at least one of elevated temperature and elevated pressure to the silk fibroin material to form a silk fibroin article, wherein the applying induces fusion between at least a portion of the silk fibroin and structural change of fibroin in the silk fibroin material. In some embodiments, the present disclosure also provides silk fibroin articles made in accordance with the methods disclosed herein. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 17/309005 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/02 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2211/04 (20130101) D10B 2211/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382058 | Cushman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark S. Cushman (West Lafayette, Indiana); Danzhou Yang (WEST LAFAYETTE, Indiana); Guanhui Wu (WEST LAFAYETTE, Indiana); Kaibo Wang (WEST LAFAYETTE, Indiana) |
| ABSTRACT | The present disclosure is directed to a method for selecting a patient with cancer for treatment with a compound of formula (I) by determining if the patient's cancer cells are MYC-positive and when the MYC promoter sequence in those cancer cells contains a nucleic acid sequence capable of forming a MYC G-quadruplex (MYC G4) (i.e. are MYC G4-positive) and treating the patient with a compound of formula (I). |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333384 |
| CURRENT CPC | Heterocyclic Compounds C07D 217/16 (20130101) C07D 401/06 (20130101) C07D 471/04 (20130101) C07D 491/056 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/57484 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382064 | SMITH |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | Vanderbilt University (Nashville, Tennessee) |
| INVENTOR(S) | Scott A. SMITH (White Bluff, Tennessee) |
| ABSTRACT | The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127953 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/35 (20130101) A61K 45/06 (20130101) Peptides C07K 16/16 (20130101) C07K 16/18 (20130101) C07K 2317/21 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/686 (20130101) Original (OR) Class G01N 33/5308 (20130101) G01N 2333/43526 (20130101) G01N 2333/43582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382066 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frances Eun-Hyung Lee (Atlanta, Georgia); Ignacio Sanz (Atlanta, Georgia); Doan C. Nguyen (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to methods of culturing and characterizing antibody secreting cells. In certain embodiments, this disclosure relates to methods of isolating antibody secreting cells, e.g., long lived plasma cells, replicating the isolated cells in growth media disclosed herein, and determining the nucleic acids sequences in the cells that encode the produced antibodies. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405918 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/163 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/6854 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382068 | Keskin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Derin Keskin (Boston, Massachusetts); Siranush Sarkizova (Boston, Massachusetts); Susan Klaeger (Cambridge, Massachusetts); Karl Clauser (Cambridge, Massachusetts); Steven Carr (Cambridge, Massachusetts); Nir Hacohen (Boston, Massachusetts); Catherine J. Wu (Boston, Massachusetts) |
| ABSTRACT | Adaptive immune responses rely on the ability of cytotoxic T cells to identify and eliminate cells displaying disease-specific antigens on human leukocyte antigen (HLA) class I molecules. Investigations into antigen processing and display have immense implications in human health, disease and therapy. To extend understanding of the rules governing antigen processing and presentation, immunopurified peptides from B cells, each expressing a single HLA class I allele, were profiled. A resource dataset containing thousands of peptides bound to distinct class I HLA-A, -B, and -C alleles was generated by implementing a novel allele-specific database search strategy. Applicants discovered new binding motifs, established the role of gene expression in peptide presentation and improved prediction of HLA-peptide binding by using these data to train machine-learning models. These streamlined experimental and analytic workflows enable direct identification and analysis of endogenously processed and presented antigens. |
| FILED | Wednesday, October 02, 2019 |
| APPL NO | 17/280380 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001114 (20180801) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6878 (20130101) Original (OR) Class G01N 33/56977 (20130101) G01N 2333/70539 (20130101) G01N 2500/04 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/10 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382073 | Berger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania); AXELA, INC. (Toronto, Canada) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania); AXELA, INC. (Toronto, Canada) |
| INVENTOR(S) | Rachel Berger (Pittsburgh, Pennsylvania); Patrick Kochanek (Pittsburgh, Pennsylvania); Brian J. Pak (Richmond Hill, Canada); Paul T. Smith (Acton, Canada); Mariya D. Kolesnikova (Toronto, Canada); David Frederick Englert (West Hartford, Connecticut) |
| ABSTRACT | The present disclosure relates to compositions and methods for identifying a subject at risk for traumatic brain injury. In particular, the instant disclosure is directed to identification of the levels of the proteins MMP-9 (Matrix Metallopeptidase 9), NSE (Neuron Specific Enolase) and VCAM-1 (Vascular Cell Adhesion Molecule 1) in a subject sample, and correlation of these protein levels with the presence of intracranial injury. In certain embodiments, subject age, gender and hemoglobin level are also correlated with the presence of intracranial injury. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/408333 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/988 (20130101) G01N 2333/70503 (20130101) G01N 2333/96494 (20130101) G01N 2800/28 (20130101) G01N 2800/50 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382126 | Park et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF H (Silver Spring, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETATY, DEPARTMENT OF H (Silver Spring, Maryland) |
| INVENTOR(S) | Bu S. Park (Bethesda, Maryland); Brenton McCright (Gaithersburg, Maryland); Sunder S. Rajan (Warrenton, Virginia) |
| ABSTRACT | An apparatus, method, and system are disclosed for improving uniformity of RF magnetic field in an MRI system, and thereby improving both signal-to-noise ratio and uniformity of imaging sensitivity across a sampling volume, to provide more uniform MRI images. A passive LC resonator develops induced EMF and induced currents in a primary RF magnetic field; the secondary magnetic field produced thereby can counteract magnetic field amplitude gradients to produce a more homogeneous RF magnetic field. In systems with separate transmit and receive coils, a shunt detuning circuit is pulsed ON to prevent interference during the transmit period. In a dual-frequency MRI machine (e.g. 19F and 1H), the RF magnetic field at the lower operating frequency can be homogenized by tuning the resonance of the passive resonator between the two operating frequencies. Another resonator can improve RF field uniformity at the higher operating frequency. Variants and experimental results are disclosed. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/411610 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3635 (20130101) G01R 33/3642 (20130101) Original (OR) Class G01R 33/5659 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383201 | Gu |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Gu (Evanston, Illinois) |
| ABSTRACT | Systems and/or methods may include an edge-computing distributed neural processor to effectively reduce the data traffic and physical wiring congestion. A local and global networking architecture may reduce traffic among multi-chips in edge computing. A mixed-signal feature extraction approach with assistance of neural network distortion recovery is also described to reduce the silicon area. High precision in signal features classification with a low bit processing circuitry may be achieved by compensating with a recursive stochastic rounding routine, and provide on-chip learning to re-classify the sensor signals. |
| FILED | Monday, October 21, 2019 |
| APPL NO | 17/286330 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/486 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) G06K 9/6289 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/063 (20130101) Original (OR) Class G06N 3/0472 (20130101) Static Stores G11C 11/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383512 | Oldham et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenn Oldham (Ann Arbor, Michigan); Thomas D. Wang (Ann Arbor, Michigan); Mayur Bhushan Birla (Ann Arbor, Michigan); Xiyu Duan (San Jose, California) |
| ABSTRACT | A computer-implemented method includes receiving a raw data set representing an image of a sample, identifying a first set of extremum by analyzing the raw data set using a metric algorithm, identifying a second set of extremum by analyzing the first set of extremum, and generating, based on the second set of extremum, a reconstructed image of the sample. A phase correcting scanner includes one or more processors, one or more scanner adapted to sequentially sample an object to generate a vector of raw data representing the object in a Lissajous pattern, and memory storing instructions that, when executed by the one or more processors, cause the computing system to receive the vector of raw data, identify a first set of extremum by analyzing the raw data set using a metric algorithm, and identify a second set of extremum by analyzing the first set of extremum. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 17/288886 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/003 (20130101) Original (OR) Class G06T 7/0012 (20130101) G06T 2207/10068 (20130101) G06T 2207/30004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383525 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Leica Microsystems Inc. (Buffalo Grove, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shih-Jong James Lee (Bellevue, Washington); Hideki Sasaki (Bellevue, Washington) |
| ABSTRACT | A computerized model compatibility regulation method for imaging applications first performs a target domain B application by computing means using at least one image X and target domain B image analytics to generate a target domain B application output for X. The method then applies a reference domain A application by computing means to generate reference domain A application output for X. The method further performs a compatibility assessment to generate at least one compatibility result for X. In addition, the method checks the compatibility result for X and if the check output is incompatible, the method performs online correction to generate a corrected application output for X. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 16/894708 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 7/0002 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383552 | PRINCE et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Jerry L. PRINCE (Baltimore, Maryland); Aaron CARASS (Towson, Maryland); Yihao LIU (Towson, Maryland) |
| ABSTRACT | A device receives a two-dimensional (2-D) image that depicts a cross-sectional view of a retina that includes a macula comprised of layers and boundaries used to segment the layers. The device converts the 2-D image to a standardized format, determines features for voxels included in the 2-D image, and generates, by using a data model to process the features, probability maps that indicate likelihoods of the voxels being in positions within particular boundaries. The device analyzes the probability maps to determine an initial set of boundary positions and to generate directional vectors that point in directions based on values included in the set of probability maps, determines a final set of boundary positions by performing a layer boundary evolution technique using the directional vectors to refine the initial set of boundary positions, and provides data that identifies the final set of boundary positions for display via an interface. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 17/310330 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/143 (20170101) Original (OR) Class G06T 2207/10101 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20182 (20130101) G06T 2207/30041 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210383717 — METHOD OF INCREMENTAL TRAINING TO CREATE NEW PATTERNS OF PHYSIOLOGICAL CONTROL SIGNALS
| US 20210383717 | Oby et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania); UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emily R. Oby (Pittsburgh, Pennsylvania); Aaron P. Batista (Pittsburgh, Pennsylvania); Steven M. Chase (Pittsburgh, Pennsylvania); Alan D. Degenhart (Pittsburgh, Pennsylvania); Matthew D. Golub (Stanford, California); Patrick T. Sadtler (Pittsburgh, Pennsylvania); Byron M. Yu (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein is a method for training a subject to produce a new neural activity pattern that results in a desired behavior. The method creates a brain-computer interface mapping between a neural activity pattern of a set of neural units and the desired behavior in an intrinsic manifold, without learning. An outside manifold perturbation of the mapping is then created, defining a new neural activity pattern lying outside of the intrinsic manifold that will produce the desired behavior. The new neural activity pattern is taught by incrementally perturbing the neural activity pattern that produces the desired behavior between the intrinsic manifold and the outside manifold perturbation and having the subject learn the desired behavior for each increment. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343050 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/372 (20210101) A61B 2505/09 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 19/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383894 | CHENNUBHOTLA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania) |
| INVENTOR(S) | SRINIVAS C. CHENNUBHOTLA (PITTSBURGH, Pennsylvania); ALBERT H. GOUGH (GLENSHAW, Pennsylvania); ANDREW M. STERN (PITTSBURGH, Pennsylvania); MICHAEL J. BECICH (WEXFORD, Pennsylvania); DOUGLASS L. TAYLOR (PITTSBURGH, Pennsylvania) |
| ABSTRACT | A method of generating a plurality of spatially co-registered data elements, each spatially co-registered data element being associated with and generated from a pair of co-registered tissue sections obtained from adjacent positions of a core taken from a tissue sample and including an image data section and a genomic data section. The method includes, for each pair of co-registered tissue sections: (i) obtaining and storing as part of a data element a plurality of multi to hyperplexed images from the imaging data section of the co-registered tissue section, (ii) generating and storing as part of the data element image data from the plurality of multi to hyperplexed images, and (iii) generating and storing as part of the data element genomic data from the genomic data section of the associated co-registered tissue section. |
| FILED | Wednesday, August 21, 2019 |
| APPL NO | 17/265954 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 1/2806 (20130101) Electric Digital Data Processing G06F 3/0482 (20130101) G06F 3/04817 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2200/24 (20130101) G06T 2207/30024 (20130101) G06T 2207/30072 (20130101) G06T 2207/30096 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210378590 | Reed et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | David A. Reed (Baltimore, Maryland); George C. Emmett (Wilmington, Delaware) |
| ABSTRACT | In an example, a method of detecting cyanide exposure of an individual comprises measuring a thiocyanate level of the individual, and comparing the measured thiocyanate level to a preset thiocyanate threshold to determine whether the measured thiocyanate level is above the preset thiocyanate threshold indicating a level of acute cyanide poisoning for which medical treatment is recommended to treat health effects of the exposure. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/246283 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4845 (20130101) Original (OR) Class A61B 5/14551 (20130101) A61B 10/0051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379147 | Kang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Yibin Kang (Princeton, New Jersey); Minhong Shen (Princeton, New Jersey) |
| ABSTRACT | Disclosed is a method of treating cancer, involving the administration of a therapeutically effective amount of an inhibitor of the epidermal growth factor receptor (EGFR) pathway and the integrin/focal adhesion kinase (FAK) pathway to a patient in need of such treatment, where the inhibitor comprises at least the first 94 amino acids of a Tinagl1 protein, any fragments with conservative substitution showing 90% or greater homology to amino acids 22-94 of a Tinagl1 protein, or a signaling peptide fused or attached to a fragment with conservative substitution showing 90% or greater homology to amino acids 22-94 of a Tinagl1 protein. |
| FILED | Tuesday, October 15, 2019 |
| APPL NO | 17/285188 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 48/0058 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Peptides C07K 14/47 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379179 | RICKE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darrell O. RICKE (Winchester, Massachusetts) |
| ABSTRACT | Provided herein are universal prophylactic compositions for preventing infection with influenza viruses by directing the immune response to highly conserved regions of the virus. Also provided are universal therapeutic compositions for treating influenza infection by targeting the highly conserved regions. Methods for using the prophylactic and therapeutic compositions are also provided. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186851 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379242 | FRANCIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EMBODY, INC. (Norfolk, Virginia) |
| ASSIGNEE(S) | EMBODY, INC. (Norfolk, Virginia) |
| INVENTOR(S) | Michael FRANCIS (Norfolk, Virginia); Nathan KEMPER (Norfolk, Virginia); Hilary WRIGGERS (Norfolk, Virginia) |
| ABSTRACT | Compositions and blends of biopolymers and copolymers are described, along with their use to prepare biocompatible scaffolds and surgically implantable devices for use in supporting and facilitating the repair of soft tissue injuries. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406409 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 38/39 (20130101) A61K 47/34 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class A61L 27/24 (20130101) A61L 27/26 (20130101) A61L 27/44 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/386 (20130101) A61L 27/3804 (20130101) A61L 2300/64 (20130101) A61L 2300/604 (20130101) A61L 2400/12 (20130101) A61L 2430/10 (20130101) A61L 2430/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379420 | Sorna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of Navy (Arlington, Virginia) |
| INVENTOR(S) | Mark Sorna (Silverdale, Washington); Jacob Yates (Poulsbo, Washington); Nathan Schuyler (Silverdale, Washington); Jose Ruiz (Bremerton, Washington) |
| ABSTRACT | A filtration mask protects the wearer against airborne hazards. The mask is reusable and may be used in a number of configurations. The mask includes filters located to the side and beneath the line of sight of the wearer. The filters may be tailored to the use and type of environmental hazard. |
| FILED | Friday, August 07, 2020 |
| APPL NO | 16/873908 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/1146 (20130101) A41D 13/1176 (20130101) A41D 31/26 (20190201) A41D 2500/50 (20130101) Devices, Apparatus or Methods for Life-saving A62B 18/10 (20130101) A62B 18/025 (20130101) Original (OR) Class A62B 18/084 (20130101) A62B 23/02 (20130101) Separation B01D 39/18 (20130101) B01D 39/2065 (20130101) B01D 2239/0435 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379559 | Weston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NuMat Technologies Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | NUMAT TECHNOLOGIES INC. (Skokie, Illinois) |
| INVENTOR(S) | Mitchell Hugh Weston (Chicago, Illinois); William Morris (Chicago, Illinois); William Joseph Hoover (Chicago, Illinois); Patrick Emmett Fuller (Chicago, Illinois); John Paul Siegfried (Chicago, Illinois); Randi Danielle Groy (Chicago, Illinois); Jeffrey Loren Wells (Chicago, Illinois); Timothy Chiaan Wang (Milwaukee, Wisconsin); Edwin Alfonso Argueta Fajardo (Chicago, Illinois) |
| ABSTRACT | This invention relates to modified MOF materials, methods of preparing them and processes using them. A modified MOF of the invention is modified by impregnating a MOF with an inorganic metal salt. The starting MOF contains at least one linker or ligand which contains an aryl amino group as part of its structure. These modified MOFs are able to adsorb either basic or acidic toxic industrial compounds (TIC). The modified MOFs can be used to remove TICs from various gaseous streams such as air. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217793 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/11 (20130101) Separation B01D 53/04 (20130101) B01D 2253/204 (20130101) B01D 2257/404 (20130101) B01D 2257/406 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/2804 (20130101) B01J 20/3202 (20130101) B01J 20/3265 (20130101) Non-metallic Elements; Compounds Thereof; C01B 37/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379560 | Weston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NuMat Technologies Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | NuMat Technologies Inc. (Skokie, Illinois) |
| INVENTOR(S) | Mitchell Hugh Weston (Chicago, Illinois); Edwin Alfonso Argueta Fajardo (Chicago, Illinois); William Morris (Chicago, Illinois); John Paul Siegfried (Chicago, Illinois); Patrick Emmett Fuller (Chicago, Illinois) |
| ABSTRACT | This invention relates to metal organic framework (MOF) compositions, methods of preparing them and methods of using them. The MOF compositions are characterized in that at least a portion of the linker molecule is an amino containing organic linker. The MOF also has a crystal size of greater than 1 μm and has been treated with an acid wash to provide a MOF in which at least 55% of the amino groups are activated amino groups of the form —NH2. The MOF compositions are useful in adsorbing various contaminants from various gas stream. One specific example is adsorbing NO2 from an air stream. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217845 |
| CURRENT CPC | Separation B01D 53/04 (20130101) B01D 2253/204 (20130101) B01D 2253/304 (20130101) B01D 2253/306 (20130101) B01D 2253/311 (20130101) B01D 2257/404 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/3071 (20130101) B01J 20/3085 (20130101) B01J 20/28011 (20130101) B01J 20/28064 (20130101) B01J 20/28071 (20130101) B01J 20/28073 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379592 | Hui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elliot En-Yu Hui (Irvine, California); Erik Morgan Werner (Irvine, California); Philip N. Duncan (Irvine, California); Transon V. Nguyen (Irvine, California); Siavash Ahrar (Irvine, California) |
| ABSTRACT | This invention describes a design for a multiwell plate that contains integrated pumps that are used to stir each well of the plate. The device employs microfluidic logic technology to drive each peristaltic pump. This enables the plates to run autonomously, requiring only a static vacuum supply for power. The devices are entirely constructed out of low-cost polymers, with no electronics, and yet contains simple digital logic circuits to control the pumps. A stack of these plates may be run continuously in a standard cell culture incubator, allowing high-throughput culture of organoids. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403513 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502738 (20130101) Original (OR) Class B01L 2300/0887 (20130101) B01L 2400/0487 (20130101) B01L 2400/0638 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379604 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinhong Zhang (Tucson, Arizona); Dongbo An (Tucson, Arizona) |
| ABSTRACT | A method is provided for using flotation techniques for separating rare earth metal compounds from bastnaesite ore. The method can include grinding the ore to obtain an aqueous slurry of particles, adding a depressant agent to the slurry and adjusting the pH to a suitable value for the flotation process, adding a collector mixture to the slurry that includes at least one hydroxamic acid, and adding a frother agent to the slurry, followed by subjecting the slurry to froth flotation. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/342109 |
| CURRENT CPC | Flotation; Differential Sedimentation B03D 1/01 (20130101) B03D 1/002 (20130101) B03D 1/02 (20130101) Original (OR) Class B03D 1/008 (20130101) B03D 2201/02 (20130101) B03D 2201/04 (20130101) B03D 2201/06 (20130101) B03D 2203/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380209 | BENSON |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TETAC, Inc (Monterey, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark BENSON (Carmel, California) |
| ABSTRACT | An underwater explosive container to house explosives and explosive tools for deployment on bottom mines, moored mines, and underwater explosive devices that can be positioned via a remotely operated vehicle or a diver for neutralizing, rendering safe, or detonating the intended target and methods of building and utilizing the underwater explosive container. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229730 |
| CURRENT CPC | Offensive or Defensive Arrangements on Vessels; Mine-laying; Mine-sweeping; Submarines; Aircraft Carriers B63G 7/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380480 | Rushing et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by the Secretary of the Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John F. Rushing (Clinton, Mississippi); Webster C. Floyd (Jackson, Mississippi); Craig Rutland (Panama City, Florida); Benjamin C. Cox (Vicksburg, Mississippi) |
| ABSTRACT | The present invention is a system for repairing asphalt. The system includes a discrete quantity of an asphalt repair composition located within a container and an induction heater. The composition is a combination of an asphalt binder, aggregate particles, and induction particles. The average diameter of the induction particles ranges from approximately 10% above to approximately 10% below an average diameter of the aggregate particles used in the composition. The induction heater heats the composition within the container by generating a magnetic field that penetrates the container. The magnetic field creates eddy currents in the induction particles. These eddy currents in turn heat the composition. Because the induction particles are distributed throughout the composition, the composition heats rapidly. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/209175 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 26/26 (20130101) Original (OR) Class C04B 2111/0075 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 6/106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380567 | PAQUETTE et al. |
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| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania); The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia); Rowan University (Mullica Hill, New Jersey) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania); The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia); Rowan University (Mullica Hill, New Jersey) |
| INVENTOR(S) | Craig Michael PAQUETTE (Ambler, Pennsylvania); John Joseph LA SCALA (Wilmington, Delaware); Joshua Matthew SADLER (Parkville, Maryland); Giuseppe Rafaello PALMESE (Hainesport, New Jersey); Alexander William BASSETT (Mullica Hill, New Jersey); Joseph Francis STANZIONE (Wilmington, Delaware) |
| ABSTRACT | A composition of matter including two optionally substituted phenol or optionally substituted aniline units separated by a furan spacer has been prepared. In particular, the chemical structure has a novolac bridge between the central furan ring and the two attached optionally substituted phenol and/or optionally substituted aniline units. These compounds can be modified to be used in various polymer resins. This new structure reduces toxicity relative to BPA/F, makes use of renewable chemicals, and produces certain beneficial polymer properties. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 17/284032 |
| CURRENT CPC | Heterocyclic Compounds C07D 307/42 (20130101) C07D 407/14 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 222/20 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380641 | BUTTERFIELD et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattlle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriel BUTTERFIELD (Seattle, Washington); Marc Joseph LAJOIE (Seattle, Washington); Neil P. KING (Seattle, Washington); David BAKER (Seattle, Washington); Daniel ELLIS (Seattle, Washington) |
| ABSTRACT | Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using synthetic nanostructures are disclosed herein. |
| FILED | Friday, November 09, 2018 |
| APPL NO | 16/762565 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Peptides C07K 14/001 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380661 | Lowe et al. |
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| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Devin B. Lowe (Abilene, Texas); Amanda L. Wooster (Abilene, Texas) |
| ABSTRACT | The present invention includes compositions and methods of making and using a fusion protein comprising a peptide, a first flexible linker, a β2-microglobulin domain, a second flexible linker, a soluble major histocompatibility complex (MHC) heavy chain and a peptide tag. |
| FILED | Tuesday, October 15, 2019 |
| APPL NO | 17/284525 |
| CURRENT CPC | Peptides C07K 14/70539 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2319/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380854 | KOHL et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PAUL A. KOHL (Atlanta, Georgia); ANTHONY ENGLER (Atlanta, Georgia); JARED SCHWARTZ (Atlanta, Georgia); GERALD GOURDIN (Atlanta, Georgia); JISU JIANG (Atlanta, Georgia); OLUWADAMILOLA PHILLIPS (Atlanta, Georgia) |
| ABSTRACT | Embodiments of the present disclosure provide for transient adhesive polymers, methods of making transient adhesive polymers, structures including the transient adhesive polymer attaching two portions of the structure to one another, and the like. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405139 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/06 (20130101) B32B 7/12 (20130101) B32B 2255/26 (20130101) B32B 2307/748 (20130101) B32B 2437/00 (20130101) B32B 2457/00 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 163/00 (20130101) Original (OR) Class C09J 169/00 (20130101) C09J 171/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380988 | Mercurio et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arthur M. Mercurio (Boston, Massachusetts); Caitlin Westberg Brown (Northborough, Massachusetts) |
| ABSTRACT | Compositions and methods for inducing tumor cell death by inhibiting prominin2 (PROM2) or heat shock factor protein 1 (HSF1), optionally in combination with an agent that promotes ferroptosis, preferably an inhibitor of glutathione peroxidase 4 (GPX4), e.g., to trigger ferroptosis in the tumor cells. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319473 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/15 (20130101) A61K 31/437 (20130101) A61K 31/496 (20130101) A61K 31/517 (20130101) A61K 31/4439 (20130101) A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1137 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/321 (20130101) C12N 2310/322 (20130101) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380990 | KIANI et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samira KIANI (Scottsdale, Arizona); Mo Reza EBRAHIMKHANI (Scottsdale, Arizona); Farzaneh MOGHADAM (Tempe, Arizona) |
| ABSTRACT | Provided herein are CRISPR-based synthetic repression systems as well as methods and compositions using the synthetic repression systems to treat septicemia, an adverse immune response in a subject and Waldanstrom macroglobulinemia. |
| FILED | Thursday, November 07, 2019 |
| APPL NO | 17/292407 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0008 (20130101) Peptides C07K 14/4703 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 15/111 (20130101) C12N 15/635 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2310/20 (20170501) C12N 2310/3519 (20130101) C12N 2830/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381057 | HU et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); WINDBER RESEARCH INSTITUTE (Windber, Pennsylvania); THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPT OF HEALTH AND HUMAN SERVICE (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hai HU (Windber, Pennsylvania); Yi ZHANG (San Diego, California); Albert KOVATICH (Bethesda, Maryland); Maxwell LEE (Bethesda, Maryland); Craig D. SHRIVER (Bethesda, Maryland) |
| ABSTRACT | The present disclosure provides gene expression profiles that are associated with cancer, including certain gene expression profiles that differentiate between cancer that is at a high risk of recurrence. The gene expression profiles can be measured at the nucleic acid or protein level. The gene expression profiles can also be used to identify a subject for cancer treatment. Also provided are kits for use in predicting cancer recurrence and/or prognosing cancer and an array comprising probes for detecting the unique gene expression profiles associated with cancer. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 17/273014 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381081 | Berggren et al. |
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| FUNDED BY |
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| APPLICANT(S) | Pioneer Astronautics (Lakewood, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Berggren (Golden, Colorado); Robert Zubrin (Golden, Colorado); John T. Henri (Longmont, Colorado); Boris Nizamov (Highlands Ranch, Colorado) |
| ABSTRACT | Novel methods of recovering neodymium and related rare earth elements from permanent magnets of various compositions are described. The methods employ processing steps including converting the magnet material to a higher surface area form such as a powder, treating the mixture with alkaline solutions to form product concentrated in neodymium and rare earth metals. Inexpensive materials such as ammonia, ammonium carbonate, carbon dioxide, water are recycled in a process that uses moderate temperatures, pressures and non-corrosive and environmentally-friendly chemicals. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407569 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 1/005 (20130101) C22B 3/44 (20130101) C22B 7/008 (20130101) C22B 59/00 (20130101) Original (OR) Class Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 10/20 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381127 | Hobart et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Karl D. Hobart (Alexandria, Virginia); Tatyana I. Feygelson (Springfield, Virginia); Marko J. Tadjer (Vienna, Virginia); Travis J. Anderson (Alexandria, Virginia); Andrew D. Koehler (Alexandria, Virginia); Samuel Graham, JR. (Lithonia, Georgia); Mark Goorsky (Valencia, California); Zhe Cheng (Atlanta, Georgia); Luke Yates (Atlanta, Georgia); Tingyu Bai (Los Angeles, California); Yekan Wang (Los Angeles, California) |
| ABSTRACT | A method for growing polycrystalline diamond films having engineered grain growth and microstructure. Grain growth of a polycrystalline diamond film on a substrate is manipulated by growing the diamond on a nanopatterned substrate having features on the order of the initial grain size of the diamond film. By growing the diamond on such nanopatterned substrates, the crystal texture of a polycrystalline diamond film can be engineered to favor the preferred <110> orientation texture, which in turn enhances the thermal conductivity of the diamond film. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/409916 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/18 (20130101) C30B 29/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381129 | Kaplan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Fiorenzo G. Omenetto (Lexington, Massachusetts); Chunmei Li (Stoneham, Massachusetts); Chengchen Guo (Wakefield, Massachusetts) |
| ABSTRACT | In some embodiments, the present disclosure provides methods including the steps of (i) providing silk fibroin material comprising substantially amorphous structure, and (ii) applying at least one of elevated temperature and elevated pressure to the silk fibroin material to form a silk fibroin article, wherein the applying induces fusion between at least a portion of the silk fibroin and structural change of fibroin in the silk fibroin material. In some embodiments, the present disclosure also provides silk fibroin articles made in accordance with the methods disclosed herein. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 17/309005 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Compositions of Macromolecular Compounds C08L 89/00 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 4/02 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2211/04 (20130101) D10B 2211/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381779 | Lockwood et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William T. Lockwood (Windsor Locks, Connecticut); Matthew William Miller (Enfield, Connecticut); Luke J. Mayo (Coventry, Connecticut) |
| ABSTRACT | A method for manufacturing a heat exchanger includes stacking a plurality of parting sheets, a plurality of lengthwise closure bars, and a plurality of widthwise closure bars to form a rectangular first heat exchanger section. The first heat exchanger section includes at least one widthwise passage extending between a pair of the widthwise closure bars and at least one lengthwise passage extending between a pair of the lengthwise closure bars. The method also includes brazing the rectangular first heat exchanger section together and cutting a first side and a second side of the rectangular first heat exchanger section to give the first heat exchanger section a tapered-trapezoid profile. The method further includes brazing an end of a second heat exchanger section to the first or second side of the first heat exchanger section. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345307 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0012 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 1/0246 (20130101) F28D 1/05366 (20130101) F28D 7/005 (20130101) F28D 9/0025 (20130101) F28D 9/0062 (20130101) F28D 2021/0021 (20130101) Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 3/025 (20130101) Original (OR) Class F28F 9/26 (20130101) F28F 2210/10 (20130101) F28F 2240/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382012 | Rahimi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Rahim Rahimi (West Lafayette, Indiana); Sophie Andree Lelievre (West Lafayette, Indiana); Amin Zareei (Lafayette, Indiana); Shirisha Chittiboyina (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to an ultrasonic device for real-time and nondestructive assessment of extracellular matrix stiffness, and the method of making and using the novel ultrasonic device. |
| FILED | Monday, March 08, 2021 |
| APPL NO | 17/194361 |
| CURRENT CPC | Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0215 (20130101) B06B 1/0622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/11 (20130101) Original (OR) Class G01N 29/2437 (20130101) G01N 2291/023 (20130101) G01N 2291/102 (20130101) G01N 2291/02827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382016 | JAURIQUI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIBRANT CORPORATION (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leanne JAURIQUI (Albuquerque, New Mexico); Thomas KÖHLER (Diez, Germany); Alexander J. MAYES (Albuquerque, New Mexico); Julieanne HEFFERNAN (Albuquerque, New Mexico); Richard LIVINGS (Albuquerque, New Mexico); Eric BIEDERMANN (Albuquerque, New Mexico) |
| ABSTRACT | Creation and use of a digital twin instance (DTI) for a physical instance of the part. The DTI may be created by a model inversion process such that model parameters are iterated until a convergence criterion related to a physical resonance inspection result and a digital resonance inspection result is satisfied. The DTI may then be used in relation to part evaluation including through simulated use of the part. The physical instance of the part may be evaluated by way of the DTI or the DTI may be used to generate maintenance schedules specific to the physical instance of the part. |
| FILED | Thursday, July 09, 2020 |
| APPL NO | 17/291746 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/04 (20130101) G01N 29/52 (20130101) G01N 29/4418 (20130101) Original (OR) Class Electric Digital Data Processing G06F 30/20 (20200101) G06F 2119/02 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382048 | UNAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRITON SYSTEMS, INC. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baris UNAL (Lowell, Massachusetts); Gulden CAMCI-UNAL (Lowell, Massachusetts); Darlin LANTIGUA (Lawrence, Massachusetts) |
| ABSTRACT | Devices and methods to perform a competitive immunoassay are disclosed. In some embodiments, the competitive immunoassay is for the detection of tacrolimus. The devices comprise a plurality of layers optionally made of cellulose-based material, wherein the plurality of layers comprises at least one read-out layer displaying a colorimetric readout of the device to indicate the result of the test to the user. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/339295 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54306 (20130101) G01N 33/54386 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382164 | Bayer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mustafa Mert Bayer (Irvine, California); Ozdal Boyraz (Irvine, California) |
| ABSTRACT | Various examples for multi-tone continuous wave detection and ranging are disclosed herein. In some embodiments, an initial signal is generated using initial radio frequency (RF) tones, and is emitted as a multi-tone continuous wave signal. The initial signal is reflected from a target and received as a reflected signal. Resultant RF tones, including a frequency, a phase and a power, are determined from the reflected signal in a frequency domain. A frequency-domain sinusoidal wave is fitted to the resultant RF tones in the frequency domain, and a distance to the target is determined using a modulation of the frequency-domain sinusoidal wave. A phase processing algorithm is applied to generate the target distance and speed by triangulating the range information encoded in the backscattered RF tones. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/409076 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 3/00 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4814 (20130101) G01S 13/06 (20130101) G01S 13/584 (20130101) Original (OR) Class G01S 17/06 (20130101) G01S 17/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382365 | GOGOTSI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yury GOGOTSI (Warminster, Pennsylvania); Pol SALLÉS PERRAMON (Manresa, Spain); David PINTO (Creteil, France); Kanit HANTANSIRISAKUL (Philadelphia, Pennsylvania); Kathleen MALESKI (Mount Airy, Maryland) |
| ABSTRACT | The present disclosure describes electrochromic devices comprising transparent conductive layer acting as an electrode, an active electrochromic film, an ion conductor, and an ion storage film at least one of which comprises at least one MXene material. |
| FILED | Tuesday, October 22, 2019 |
| APPL NO | 17/287161 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/155 (20130101) Original (OR) Class G02F 1/1508 (20130101) G02F 1/15165 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382371 | Ni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingjie Ni (State College, Pennsylvania); Xuexue Guo (State College, Pennsylvania); Yimin Ding (State College, Pennsylvania); Yao Duan (State College, Pennsylvania); Xi Chen (State College, Pennsylvania) |
| ABSTRACT | Embodiments relate to a photonic component having a metasurface. The metasurface includes a substrate with a thin-layer of meta-atoms disposed thereon. The photonic component includes a waveguide having a top surface, wherein the metasurface is disposed on at least a portion of the top surface such that the meta-atoms form an array on the top surface. The photonic component includes a sandwich nano-bar antenna formed in or on the metasurface. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/303741 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/2955 (20130101) Original (OR) Class G02F 2202/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382696 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianhua Yang (Hadley, Massachusetts); Qiangfei Xia (Amherst, Massachusetts); Hao Jiang (Sunderland, Massachusetts) |
| ABSTRACT | A true random number generator device based on a diffusive memristor is disclosed. The random number generator device includes a diffusive memristor driven by a pulse generator circuit. The diffusive memristor produces a stochastically switched output signal. A comparator circuit receives the stochastically switched output signal from the diffusive memristor and generates an output signal having a random pulse width. An AND gate logic circuit is driven by a clock signal and the output signal from the comparator circuit. The AND gate logic circuit produces a combined output signal. A counter circuit receives the combined output signal from the AND gate logic circuit and generates a random bit string output signal. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407587 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/588 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 45/085 (20130101) H01L 45/146 (20130101) H01L 45/1253 (20130101) H01L 45/1266 (20130101) Pulse Technique H03K 3/84 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383147 | RAJARAMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Booz Allen Hamilton Inc. (McLean, Virginia) |
| ASSIGNEE(S) | Booz Allen Hamilton Inc. (McLean, Virginia) |
| INVENTOR(S) | Srinivasan RAJARAMAN (Laurel, Maryland); Nathaniel Jackson SHORT (Annapolis, Maryland); Shuowen HU (Adelphi, Maryland); Matthew THIELKE (Adelphi, Maryland); Robert NGUYEN (Laurel, Maryland) |
| ABSTRACT | A method and system for translating fiducial points in multispectral imagery includes capturing a first image of an object by a first imaging device in a first spectral domain, the first spectral domain being the visible spectrum; capturing a second image of the object by a second imaging device in the first spectral domain; capturing a third image of the object by a third imaging device in a second spectral domain, the second spectral domain being outside the visible spectrum; determining three-dimensional location information of one or more fiducial points of the object based on the first and second visible spectrum images; projecting the one or more fiducial points from the three-dimensional image of the object onto an two-dimensional image plane of the third image; and translating the location of the one or more fiducial points of the object from first and second visible spectrum images to the third image. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 16/895846 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00201 (20130101) G06K 9/00221 (20130101) G06K 9/2054 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383506 | Braunreiter |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis C. Braunreiter (San Diego, California) |
| ABSTRACT | A system includes at least one imaging sensor configured to capture images of a target. The system also includes at least one controller configured to generate super-resolution images of the target using the captured images and identify multiple edges of the target using the super-resolution images. The at least one controller is also configured to identify an aimpoint on the target based on the identified edges of the target. In addition, the at least one controller is configured to update the aimpoint on the target as the target moves over time. The system may further include a high-energy laser (HEL) configured to generate an HEL beam that is directed towards the target, and the at least one controller may be configured to adjust one or more optical devices to direct the HEL beam at the identified aimpoint on the target. |
| FILED | Tuesday, December 03, 2019 |
| APPL NO | 16/702279 |
| CURRENT CPC | Weapon Sights; Aiming F41G 3/145 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 13/005 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/66 (20130101) Image Data Processing or Generation, in General G06T 3/4053 (20130101) Original (OR) Class G06T 7/13 (20170101) G06T 7/32 (20170101) G06T 7/136 (20170101) G06T 2207/20036 (20130101) G06T 2207/20221 (20130101) Pictorial Communication, e.g Television H04N 5/2256 (20130101) H04N 5/23232 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383944 | Graber et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lukas Graber (Atlanta, Georgia); Chanyeop Park (Starkville, Mississippi); Jia Wei (Atlanta, Georgia) |
| ABSTRACT | A dielectric material with heat transfer properties includes a first fluid and a second fluid different from the first fluid and miscible with the first fluid. The first fluid and the second fluid are mixed with each other so as to form a mixture and are kept at a temperature and a pressure so that the mixture is maintained in a supercritical phase. The mixture has at least one parameter that is preferably different from a corresponding parameter in both a supercritical phase of the first fluid and a supercritical phase of the second fluid. In a method of insulating electrical contacts and removing heat therefrom, the mixture is disposed about the electrical contacts and is maintained at a temperature and at a pressure that causes the mixture to be in a supercritical phase so that the mixture has favorable dielectric and heat transfer properties. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407829 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 3/002 (20130101) H01B 3/16 (20130101) Original (OR) Class H01B 17/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384138 | Coffey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida); The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin R. Coffey (Oviedo, Florida); Edward Dein (Saint Cloud, Florida); Sameer Ezzat (Orlando, Florida); Prabhu Doss Mani (Memphis, Tennessee); Katayun Barmak (Elmsford, New York) |
| ABSTRACT | Crystallographic orientations of ruthenium films and related methods are disclosed. Single crystal ruthenium films are provided with crystallographic orientations that arrange a c-axis of the ruthenium crystal structure in a direction that corresponds with a plane of the film or along a direction that corresponds with a surface of a substrate on which the film is formed. While ruthenium films typically form with the c-axis perpendicular to the surface of the substrate or as a polycrystalline film with a random crystallographic orientation, substrate surfaces may be configured with a crystallographic surface net that promotes non-perpendicular c-axis orientations of ruthenium. The substrate may be formed with a metal-terminated surface in certain arrangements. In this regard, ruthenium films may be configured as metallic interconnects for devices where directions of lowest electrical resistivity within the crystal structure are arranged to correspond with the direction of current flow in the devices. |
| FILED | Tuesday, June 09, 2020 |
| APPL NO | 16/896356 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/32051 (20130101) H01L 23/528 (20130101) H01L 23/53214 (20130101) H01L 23/53257 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384362 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Wenshen Li (Ithaca, New York); Zongyang Hu (Ithaca, New York); Kazuki Nomoto (Ithaca, New York); Debdeep Jena (Ithaca, New York); Huili Grace Xing (Ithaca, New York) |
| ABSTRACT | Described herein are the design and fabrication of Group III trioxides, such as β-Ga2O3, trench-MOS barrier Schottky (TMBS) structures with high voltage (>1 kV), low leakage capabilities, while addressing on the necessary methods to meet the re-quirements unique to Group III trioxides, such as β-Ga2O3. |
| FILED | Wednesday, October 30, 2019 |
| APPL NO | 17/291689 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) H01L 29/36 (20130101) H01L 29/407 (20130101) H01L 29/8725 (20130101) Original (OR) Class H01L 29/66969 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384520 | Arugula et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CFD Research Corporation (Huntsville, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mary Arugula (Huntsville, Alabama); Erica Wagner Pinchon (Huntsville, Alabama); Sameer Singhal (Huntsville, Alabama); Yevgenia Ulyanova (Huntsville, Alabama) |
| ABSTRACT | A method of producing electrical power includes: a cathode having a porphyrin precursor attached to a substrate, and having a first enzyme, wherein the first enzyme reduces oxygen; an anode having a first region of an anode substrate and having a gold nanoparticle composition located thereon, and having a second region of the anode substrate having an enzyme composition located thereon, wherein the enzyme composition includes a second enzyme, wherein the first region and second region are separate regions; and a neutral fuel liquid in contact with the anode and cathode, the neutral fuel liquid having a neutral pH and a fuel reagent; and operating the fuel cell to produce electrical power with the neutral fuel liquid having the neutral pH and the fuel reagent. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406947 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/926 (20130101) H01M 4/8673 (20130101) Original (OR) Class H01M 4/9016 (20130101) H01M 4/9041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384599 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhaoyang C. Wang (Carlisle, Massachusetts); Ajay Subramanian (Nashua, New Hampshire); Jason C. Soric (North Andover, Massachusetts); Matthew A. Morton (Lynnfield, Massachusetts) |
| ABSTRACT | A method includes receiving a radio frequency (RF) input signal using at least one non-reciprocal circulator. The method also includes generating an RF output signal using at least one of multiple reflective filter elements. Each reflective filter element is configured to receive an RF signal from the at least one non-reciprocal circulator and to provide a filtered RF signal to the at least one non-reciprocal circulator. The reflective filter elements include amplitude change reflectors configured to modify amplitudes of the RF signal at different frequencies. The RF output signal represents the RF input signal as modified by the at least one of the reflective filter elements. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307261 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/38 (20130101) Original (OR) Class Impedance Networks, e.g Resonant Circuits; Resonators H03H 11/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384600 | Nagulu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aravind Nagulu (New York, New York); Harish Krishnaswamy (New York, New York) |
| ABSTRACT | A circuit comprising a differential transmission line and eight switches provides non-reciprocal signal flow. In some embodiments, the circuit can be driven by four local oscillator signals using a boosting circuit. The circuit can be used to form a gyrator. The circuit can be used to form a circulator. The circuit can be used to form three-port circulator than can provide direction signal flow between a transmitter and an antenna and from the antenna to a receiver. The three-port circulator can be used to implement a full duplex transceiver that uses a single antenna for transmitting and receiving. |
| FILED | Tuesday, January 21, 2020 |
| APPL NO | 17/288155 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/383 (20130101) Original (OR) Class Demodulation or Transference of Modulation From One Carrier to Another H03D 7/1466 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384647 | Taylor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (, None) |
| INVENTOR(S) | Brian L. Taylor (Anna, Texas); David M. Dyer (Prosper, Texas); Steven Sprinkle (Van Alstyne, Texas); Paul E. Schlittler (Mc Kinney, Texas) |
| ABSTRACT | A radio frequency (RF) circuit connection assembly comprises a RF circuit board and a RF connector. The RF circuit board has a first side and a second side opposite the first side. A RF circuit is located on the first side and an aperture extends through the RF circuit board from the first side to the second side. The RF connector comprises a barrel having a socket configured to receive a RF bullet, a flange having a mounting surface, and a RF connector pin extending laterally from the barrel. The barrel of the RF connector extends through the aperture of the RF circuit board such that the mounting surface of the flange is seated against the first side of the RF circuit board, and the RF connector pin is electrically coupled to the RF circuit on the first side of the RF circuit board. |
| FILED | Tuesday, June 09, 2020 |
| APPL NO | 16/897149 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 9/16 (20130101) H01Q 21/28 (20130101) H01Q 23/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384657 | Whatcott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rosemount Aerospace Inc. (Burnsville, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neal R. Whatcott (Chaska, Minnesota); Jason Graham (Prior Lake, Minnesota); Gary Willenbring (Waconia, Minnesota) |
| ABSTRACT | A stacked circuit card assembly includes a power supply having a positive terminal and a negative terminal, a first circuit card having a first via electrically connected to the positive terminal and a second via electrically connected to the negative terminal, and a second circuit card having a third via aligned with the first via and a fourth via aligned with the second via. The assembly further includes a first conductive stand-off disposed between the first circuit card and the second circuit card and structurally supporting the first circuit card with respect to the second circuit card, and a second conductive stand-off disposed between the first circuit card and the second circuit card and structurally supporting the first circuit card with respect to the second circuit card. The first conductive stand-off provides a conductive pathway between the first via and the third via, and the second conductive stand-off provides a conductive pathway between the second via and the fourth via. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 16/891579 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 12/714 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384692 | Helle |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Michael H. Helle (Arlington, Virginia) |
| ABSTRACT | A laser architecture for selectively producing short high-energy laser pulses having octave-spanning, continuous tunability. Two oppositely chirped pulses are used in combination with a pair of tunable pulse stretcher/compressors to produce a short, high-energy, tunable, broadband pulse. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/412339 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/39 (20130101) G02F 1/392 (20210101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0057 (20130101) Original (OR) Class H01S 3/0085 (20130101) H01S 3/1106 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384695 | Puckett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | Matthew Wade Puckett (Phoenix, Arizona); Karl D. Nelson (Plymouth, Minnesota); Jianfeng Wu (Tucson, Arizona) |
| ABSTRACT | Systems and methods for a self-injection locked SBS laser are provided herein. In certain embodiments, a system includes a pump laser source providing a pump laser; an SBS resonator receiving the pump laser through a first port and scattering some of the pump laser to provide an SBS laser through the first port, wherein a frequency shift of Brillouin scattering within the SBS resonator is an integer multiple of a free-spectral range for the SBS resonator; a filter receiving the pump laser on a first filter port and the SBS laser on a second filter port, wherein the pump laser is output through the second filter port and the SBS laser is output through a drop port; and a pump laser path coupling the output pump laser into the pump laser source, wherein a frequency of the pump laser becomes locked to a resonance frequency of the SBS resonator. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 16/892016 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/083 (20130101) H01S 3/302 (20130101) H01S 3/1022 (20130101) H01S 3/1086 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384762 | Isobe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Hiroki Isobe (Cambridge, Massachusetts); Qiong MA (Allston, Massachusetts); Liang FU (Winchester, Massachusetts); Nuh GEDIK (Watertown, Massachusetts); Suyang XU (Allston, Massachusetts); Pablo Jarillo-Herrero (Cambridge, Massachusetts) |
| ABSTRACT | Rectification is a process that converts electromagnetic fields into direct current (DC). Such a process underlies a wide range of technologies, including wireless communication, wireless charging, energy harvesting, and infrared detection. Existing rectifiers are mostly based on semiconductor diodes, with limited applicability to small voltages or high frequency inputs. Here, we present an alternative approach to current rectification that uses the electronic properties of quantum crystals without semiconductor junctions. We identify a new mechanism for rectification from skew scattering due to the chirality of itinerant electrons in time-reversal-invariant but inversion-breaking materials. Our calculations reveal large, tunable rectification effects in graphene multilayers and transition metal dichalcogenides. These effects can be used in high-frequency rectifiers by rational material design and quantum wavefunction engineering. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345078 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/001 (20200101) Original (OR) Class H02J 50/27 (20160201) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/4208 (20130101) H02M 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384918 | SOLOMON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Trustees of Boston University (Boston, Massachusetts); National University of Ireland, Maynooth (Maynooth, Ireland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit SOLOMON (Cambridge, Massachusetts); Muriel MEDARD (Belmont, Massachusetts); Kenneth R. DUFFY (Dublin, Ireland); Rabia Tugce Yazicigil KIRBY (Cambridge, Massachusetts); Vaibhav BANSAL (Boston, Massachusetts); Wei AN (Newton, Massachusetts) |
| ABSTRACT | Described is a decoder suitable for use with any communication or storage system. The described decoder has a modular decoder hardware architecture capable of implementing a noise guessing process and due to its dependency only on noise, the decoder design is independent of any encoder, thus making it a universal decoder. Hence, the decoder architecture described herein is agnostic to any coding scheme. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225818 |
| CURRENT CPC | Coding; Decoding; Code Conversion in General H03M 13/1105 (20130101) Original (OR) Class H03M 13/1148 (20130101) H03M 13/2778 (20130101) H03M 13/6575 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210385363 | Klosterman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TAU TECHNOLOGIES, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John Klosterman (Corrales, New Mexico) |
| ABSTRACT | A plurality of multi-camera systems and methods for imaging faint objects are disclosed, which includes an array of cameras that, when taken alone, are incapable of imaging such objects. The systems and methods may include common field arrays, hybrid field arrays, and/or adaptive field arrays. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/407048 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/4038 (20130101) G06T 7/33 (20170101) G06T 7/37 (20170101) G06T 2207/10052 (20130101) G06T 2207/20061 (20130101) G06T 2207/30181 (20130101) Pictorial Communication, e.g Television H04N 5/232 (20130101) H04N 5/247 (20130101) H04N 5/265 (20130101) H04N 5/2258 (20130101) Original (OR) Class H04N 5/3415 (20130101) H04N 5/23218 (20180801) H04N 5/23238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210385386 | Lunt |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Gary A. Lunt (Riverside, California) |
| ABSTRACT | A method of determining geo-reference data for a portion of a measurement area includes providing a monitoring assembly comprising a ground station, providing an imaging assembly comprising an imaging device with a lens operably coupled to an aerial device, hovering the aerial device over a measurement area, capturing at least one image of the measurement area within the imaging device, transmitting the at least one image to the ground station using a data transmitting assembly, and scaling the at least one image to determine the geo-reference data for the portion of the measurement area by calculating a size of a field-of-view (FOV) of the lens based on a distance between the imaging device and the measurement area. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407772 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 3/08 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 3/38 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0263 (20130101) G01S 19/49 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0063 (20130101) G06K 9/00771 (20130101) Image Data Processing or Generation, in General G06T 7/73 (20170101) G06T 7/246 (20170101) Traffic Control Systems G08G 5/0013 (20130101) G08G 5/0026 (20130101) G08G 5/0069 (20130101) G08G 5/0078 (20130101) G08G 5/0086 (20130101) Pictorial Communication, e.g Television H04N 5/23296 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210378511 | Skubic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marjorie Skubic (Columbia, Missouri); Marilyn J. Rantz (Rocheport, Missouri); Mihail Popescu (Columbia, Missouri); Shuang Wang (Irvine, California); Isaac J. Sledge (Columbia, Missouri); Rainer Dane A. Guevara (Columbia, Missouri); Elena Florea (Columbia, Missouri); James M. Keller (Columbia, Missouri) |
| ABSTRACT | Methods and systems for an integrated sensor network are described. In one embodiment, sensor data may be accessed from a plurality of motion sensors and a bed sensor deployed in a living unit for a first time period. An activity pattern for the first time period may be identified based on at least a portion of sensor data associated with the first time period. The activity pattern may represent a physical and cognitive health condition of a person residing in the living unit. Additional sensor data may be accessed from the motion sensors and the bed sensor deployed for a second time period. A determination of whether a deviation of the activity pattern of the first time period has occurred for the second time period may be performed. An alert may be generated based on a determination that the derivation has occurred. In some embodiments, user feedback is captured on the significance of the alerts, and the alert method is customized based on this feedback. Additional methods and systems are disclosed. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/409974 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/002 (20130101) Original (OR) Class A61B 5/021 (20130101) A61B 5/0022 (20130101) A61B 5/0205 (20130101) A61B 5/1113 (20130101) A61B 5/1118 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/0423 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378529 | COLBURN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | David COLBURN (New York, New York); Samuel K. SIA (New York, New York) |
| ABSTRACT | The disclosed subject matter includes a wearable device for blood pressure monitoring. The embodiments employ a set of sensors to calculate a relative external pressure. A transmural pressure error can be calculated based on the relative external pressure. A measured transmural pressure can be corrected based on the transmural pressure error. Some embodiments track altitude to calculate relative external pressure error. Some embodiments track arm orientation to calculate relative external pressure error. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400485 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/725 (20130101) A61B 5/02125 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 5/7278 (20130101) A61B 2560/0223 (20130101) A61B 2560/0257 (20130101) A61B 2562/0219 (20130101) A61B 2562/0223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378532 | MATTHEWS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cardiac Motion, LLC (Sacramento, California); The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis MATTHEWS (Meadow Vista, California); Xiaomeng GAO (Dublin, California); Xiaonan JIANG (Davis, California); Xiaoguang LIU (Davis, California); Jeremy THOMPSON (Grange, Australia); Kylie DUNNING (Prospect, Australia); Kenneth PAWLAK (Reno, Nevada); Chris RYMAN (Crystal Bay, Nevada) |
| ABSTRACT | Described herein are systems, devices, and methods for non-invasive pregnancy testing. The systems, devices, and methods can be used to provide pregnancy status information of a subject by detecting cardiovascular activity of a fetus in the subject. Subjects can include ruminants, ungulates, and humans. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343364 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 29/005 (20130101) Diagnosis; Surgery; Identification A61B 5/05 (20130101) A61B 5/0011 (20130101) A61B 5/02411 (20130101) Original (OR) Class A61B 5/02438 (20130101) A61B 5/02444 (20130101) A61B 5/6831 (20130101) A61B 5/6867 (20130101) A61B 2503/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378627 | Yarmush et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Martin L. Yarmush (New Brunswick, New Jersey); Alvin Chen (New Brunswick, New Jersey); Max Balter (New Brunswick, New Jersey); Joshua Leipheimer (New Brunswick, New Jersey) |
| ABSTRACT | A device and method for directing a cannula toward a target location under a patient's skin. The device is handheld and the device operations may be automated. The device includes an imaging probe for imaging the target location, a positioning unit for manipulating a cannula towards the target location, and a processor. The processor receives imaging data from the imaging probe, cannula pose data from at least one cannula position sensor, and device pose data from at least one device position sensor. The target location is identified from the imaging data, and a trajectory for manipulating the cannula towards the target location is determined based on the imaging data, the cannula pose data, and the device pose data. The processor may determine that the trajectory becomes misaligned with the target position, and may update to a corrected trajectory based on the imaging data, cannula pose data, and the device pose data. |
| FILED | Wednesday, October 09, 2019 |
| APPL NO | 17/284018 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) A61B 8/12 (20130101) A61B 8/466 (20130101) A61B 8/0841 (20130101) Original (OR) Class A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378870 | Davis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett H. Davis (Salt Lake City, Utah); Jayant P. Agarwal (Salt Lake City, Utah); Caleb A. Lade (Salt Lake City, Utah) |
| ABSTRACT | A wound dressing including a porous biosynthetic polymer film comprising a poly(lactide-co-caprolactone) (“PLC”) copolymer or other suitable polymer matrix, and a local analgesic loaded therein, to provide pain relief over an extended period of time (e.g., for 5-7 days), e.g., for healing of a partial thickness dermal injury. The PLC copolymer may have a particular lactide/caprolactone molar ratio (e.g., from 2:1 to 9:1) to ensure slow, sustained release of the bupivacaine or other analgesic. The dressing may provide a water vapor transmission rate from 1000 g/m2·day to 3000 g/m2·day to facilitate fast healing and regrowth of new epithelial tissue beneath the dressing. The dressing is configured to remain positioned over the dermal injury, providing wound protection for about 14 days, after which is simply debrides away, falls off, or is easily and painlessly removed, once new epithelial tissue regrows. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/409211 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 13/00063 (20130101) Original (OR) Class A61F 2013/00906 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/7007 (20130101) A61K 31/167 (20130101) A61K 31/445 (20130101) A61K 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210378976 | XIE |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jin XIE (Watkinsville, Georgia) |
| ABSTRACT | Disclosed are particles comprising lithium salts and methods for their use in treating inflammatory conditions. |
| FILED | Friday, January 18, 2019 |
| APPL NO | 16/962946 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/5115 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 9/5161 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379099 | ISAACS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lyle David ISAACS (Silver Spring, Maryland); Steven MURKLI (College Park, Maryland) |
| ABSTRACT | Disclosed herein are water-soluble, cyclic cucurbit[n]uril, compositions containing the same, methods of preparation thereof, and uses thereof. These compounds are useful, for example, as sequestering agents for various agents, such as, for example, drugs of abuse. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335542 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/787 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379263 | Gogotsi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yury Gogotsi (Ivyland, Pennsylvania); Vadym Mochalin (Rolla, Missouri); Nicholas Pescatore (Ambler, Pennsylvania) |
| ABSTRACT | The present disclosure is directed to methods of removing proteins, including cytokines, from blood and blood products, the methods comprising contacting the blood or blood product with a form of carbon having high graphitic contents and slit-shaped mesopores and macropores, the pore size dimensions chosen to be comparable to the size of the proteins, wherein the contacting results in the removal of high levels of the protein from the blood or blood product in minutes or hours. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/402856 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3486 (20140204) Original (OR) Class A61M 2202/07 (20130101) A61M 2202/0445 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/205 (20130101) B01J 20/321 (20130101) B01J 20/28083 (20130101) B01J 20/28085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379356 | Criscione et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); CORINNOVA INCORPORATED (Houston, Texas) |
| ASSIGNEE(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas); CORINNOVA INCORPORATED (Houston, Texas) |
| INVENTOR(S) | John C. Criscione (College Station, Texas); Lewis D. Harrison (Flower Mound, Texas); Michael R. Moreno (College Station, Texas); Christina M. Bolch (Houston, Texas); Dennis I. Robbins (Richardson, Texas); Saurabh Biswas (College Station, Texas); Boris Leschinsky (Mahwah, New Jersey) |
| ABSTRACT | The present invention provides a direct cardiac compression device for individualized support at different locations around the heart, the device comprising: a housing shaped to conform to the shape of the heart and to surround the heart; two or more active chambers positioned adjacent to the housing, wherein the two or more active comprise one or more right active chambers positioned on the right ventricle side of the heart and one or more left active chambers positioned on the left ventricle side of the heart, wherein the two or more active chambers are designed to conform to the shape of the heart, each active chamber comprising an inner membrane sealingly attached along its periphery to the housing and an active fluid individually supplied thereto; a right input connection in fluid communication with the one or more right active chambers to ingress the active fluid into each of the one or more right active chambers; a left input connection in fluid communication with the one or more left active chambers to ingress the active fluid into each of the one or more left active chambers, and a driver in fluid communication with each of the right input connection and the left input connection to individually and periodically ingress and egress the active fluid therefrom, wherein the active fluid individually inflates the one or more right active chambers and the one or more left active chambers to compress the heart. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 17/395052 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2481 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/148 (20210101) A61M 60/268 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379549 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongxia LIU (College Park, Maryland); Su Cheun OH (College Park, Maryland) |
| ABSTRACT | Disclosed herein are methane conversion devices that achieve autothermal conditions and related methods using the methane conversion devices. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 17/288333 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/001 (20130101) B01J 8/008 (20130101) B01J 8/065 (20130101) Original (OR) Class B01J 21/08 (20130101) B01J 23/745 (20130101) B01J 35/1009 (20130101) B01J 2208/00017 (20130101) B01J 2208/024 (20130101) B01J 2208/065 (20130101) Acyclic or Carbocyclic Compounds C07C 2/84 (20130101) C07C 2521/08 (20130101) C07C 2523/745 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379558 | Holmberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Vincent Holmberg (Seattle, Washington); Elena Pandres (Seattle, Washington); Peter J. Pauzauskie (Seattle, Washington); Matthew J. Crane (Seattle, Washington); E. James Davis (Seattle, Washington) |
| ABSTRACT | The present disclosure describes radiation-assisted, substrate-free, and solution-based nanostructure (e.g., a nanotube and/or a nanowire (NW)) growth processes. The processes use the high absorption coefficient and high density of free charge carriers in particle seeds (e.g., nanoparticles, metal nanoparticles, and/or metal nanocrystals) to photothermally drive semiconductor nanostructure growth. The processes can be performed at atmospheric pressure, without specialized equipment such as specialized heating equipment and/or high-pressure reaction vessels. |
| FILED | Wednesday, October 30, 2019 |
| APPL NO | 17/287077 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/121 (20130101) Original (OR) Class B01J 2219/12 (20130101) B01J 2219/089 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 9/24 (20130101) B22F 2301/30 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/54 (20130101) C01P 2004/16 (20130101) C01P 2004/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379592 | Hui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elliot En-Yu Hui (Irvine, California); Erik Morgan Werner (Irvine, California); Philip N. Duncan (Irvine, California); Transon V. Nguyen (Irvine, California); Siavash Ahrar (Irvine, California) |
| ABSTRACT | This invention describes a design for a multiwell plate that contains integrated pumps that are used to stir each well of the plate. The device employs microfluidic logic technology to drive each peristaltic pump. This enables the plates to run autonomously, requiring only a static vacuum supply for power. The devices are entirely constructed out of low-cost polymers, with no electronics, and yet contains simple digital logic circuits to control the pumps. A stack of these plates may be run continuously in a standard cell culture incubator, allowing high-throughput culture of organoids. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403513 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502738 (20130101) Original (OR) Class B01L 2300/0887 (20130101) B01L 2400/0487 (20130101) B01L 2400/0638 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379602 | FAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); Fraunhofer USA (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); Fraunhofer USA (East Lansing, Michigan) |
| INVENTOR(S) | Qi Hua FAN (Okemos, Michigan); Keliang WANG (Okemos, Michigan) |
| ABSTRACT | An electrode apparatus and method remove a polarized molecule in a fluid. In another aspect, a non-uniform electric field is created between an anode and a cathode, the fluid flows within a gap between the cathode and the anode, and the polarized molecule is driven by an electrostatic force to and adsorbed on the anode without experiencing a chemical reaction. |
| FILED | Tuesday, February 18, 2020 |
| APPL NO | 17/431989 |
| CURRENT CPC | Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 5/005 (20130101) B03C 5/026 (20130101) Original (OR) Class Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/48 (20130101) C02F 2101/36 (20130101) C02F 2201/009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379756 | GUERIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelleher GUERIN (Baltimore, Maryland); Gregory HAGER (Baltimore, Maryland) |
| ABSTRACT | Methods and systems for connection-driven generation of robotic user interfaces and modification of robotic properties include detecting a connection of a robotic peripheral to a robot; obtaining a peripheral property set corresponding to the robotic peripheral, wherein the peripheral property set includes one or more properties of the robotic peripheral; modifying, based on the peripheral property set, a robotic property set that includes one or more properties of the robot to provide a modified robotic property set; generating, during runtime, a robotic graphical user interface (“RGUI”) dynamically based on the peripheral property set, wherein the RGUI provides at least one user-accessible interface to control the robot and the robotic peripheral; and controlling, based on the modified robotic property set, the robot and the robotic peripheral in response to user input received via the RGUI. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403143 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/161 (20130101) Original (OR) Class B25J 9/1671 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/409 (20130101) G05B 2219/40095 (20130101) G05B 2219/40099 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379758 | CHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Diligent Robotics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivian Yaw-Wen CHU (Austin, Texas); Shuai LI (Austin, Texas); Forrest GREEN (Austin, Texas); Peter WORSNOP (Austin, Texas); Andrea Lockerd THOMAZ (Austin, Texas) |
| ABSTRACT | Systems, apparatus, and methods are described for robotic learning and execution of skills. A robotic apparatus can include a memory, a processor, sensors, and one or more movable components (e.g., a manipulating element and/or a transport element). The processor can be operatively coupled to the memory, the movable elements, and the sensors, and configured to obtain information of an environment, including one or more objects located within the environment. In some embodiments, the processor can be configured to learn skills through demonstration, exploration, user inputs, etc. In some embodiments, the processor can be configured to execute skills and/or arbitrate between different behaviors and/or actions. In some embodiments, the processor can be configured to learn an environmental constraint. In some embodiments, the processor can be configured to learn using a general model of a skill. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188445 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/163 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380412 | Narayan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jagdish Narayan (Raleigh, North Carolina) |
| ABSTRACT | In various exemplary embodiments, the present disclosure provides a process for the conversion of certain polymers into diamond and diamond-like materials using laser pulse annealing. The process includes transforming the polymer to carbon, melting the carbon and quenching the carbon melt into to form Q-carbon, diamond, and/or graphene. The process can be applied to a polymer film such aa a polytetrafluoroethylene (PTFE) tape. An object can be coated with the polymer film which can then be converted to Q-carbon, diamond, and/or graphene using laser pulse annealing. A process is also provided for making a three-dimensional object using a combination of, for example, 3D printing the polymer and converting each layer of polymer into Q-carbon, diamond and/or graphene. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335164 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/3094 (20130101) A61F 2002/3097 (20130101) A61F 2002/30971 (20130101) A61F 2002/30985 (20130101) A61F 2310/0058 (20130101) A61F 2310/00586 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/188 (20170801) B29C 71/02 (20130101) B29C 71/04 (20130101) B29C 2071/025 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2027/18 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) Original (OR) Class C01B 32/26 (20170801) C01B 32/184 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380635 | Thayumanavan et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sankaran Thayumanavan (Amherst, Massachusetts); Richard W. Vachet (Belchertown, Massachusetts); Jiaming Zhuang (Amherst, Massachusetts); Bo Zhao (Sunderland, Massachusetts) |
| ABSTRACT | The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, delivery, probing and/or analytical measurements of small molecule drugs, proteins, antibodies and other biomolecules. The invention provides novel biologically active agents useful as diagnostics or therapeutics, and related composition and methods of uses thereof. |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/254433 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/54 (20170801) A61K 47/6803 (20170801) Acyclic or Carbocyclic Compounds C07C 69/593 (20130101) C07C 229/30 (20130101) C07C 229/34 (20130101) C07C 235/28 (20130101) C07C 271/28 (20130101) C07C 311/53 (20130101) C07C 323/54 (20130101) Heterocyclic Compounds C07D 213/20 (20130101) C07D 213/74 (20130101) Peptides C07K 1/13 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380641 | BUTTERFIELD et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattlle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriel BUTTERFIELD (Seattle, Washington); Marc Joseph LAJOIE (Seattle, Washington); Neil P. KING (Seattle, Washington); David BAKER (Seattle, Washington); Daniel ELLIS (Seattle, Washington) |
| ABSTRACT | Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using synthetic nanostructures are disclosed herein. |
| FILED | Friday, November 09, 2018 |
| APPL NO | 16/762565 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Peptides C07K 14/001 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380721 | Zhan et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chang-Guo Zhan (Lexington, Kentucky); Fang Zheng (Lexington, Kentucky); Chunhui Zhang (Lexington, Kentucky) |
| ABSTRACT | Compositions and methods are provided for use in binding opioids, such as 6-MAM, morphine, heroin, hydrocodone, oxycodone, meperidine, and fentanyl, while avoiding binding to OUD treatment agents, such as naloxone and naltrexone. Methods are also provided for use in a systematic structure-based virtual screening and design approach for identification of such antibodies. Methods are also provided for use in treating OUD. Methods are also provided for use in detecting an opioid in a sample. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/336165 |
| CURRENT CPC | Peptides C07K 16/44 (20130101) Original (OR) Class C07K 2317/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/9486 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/30 (20190201) G16B 30/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380726 | Hsiao et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin S. Hsiao (Setauket, New York); Sunil Sharma (East Setauket, New York); Priyanka R. Sharma (East Setauket, New York); Ken I. Johnson (Port Jefferson Station, New York) |
| ABSTRACT | The present disclosure provides cellulose/metal composites and their use in removing impurities from liquids, including water. Carboxylated nanocelluloses are combined with metal ions and the resulting composite may be contacted with a liquid, including water, to remove impurities therefrom. |
| FILED | Wednesday, October 30, 2019 |
| APPL NO | 17/285543 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/281 (20130101) C02F 1/286 (20130101) C02F 1/288 (20130101) C02F 2101/14 (20130101) C02F 2305/08 (20130101) Polysaccharides; Derivatives Thereof C08B 15/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380771 | BAE et al. |
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| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Chulsung BAE (Cohoes, New York); Jong Yeob JEON (Troy, New York) |
| ABSTRACT | Ion exchange membranes for use in electrochemical energy conversion and storage applications include copolymers having a backbone produced from an olefin, such as ethylene, and a cyclic olefin, such as norbornene. Haloalkyl side chains with terminal halide groups are connected to the polymer backbone via Friedel-Crafts alkylation. The halide groups are then replaced with ionic groups via substitution. The ion exchange membrane material can then be cast or impregnated into a reinforcing mesh to form cation exchange membrane or anion exchange membranes. Rigidity of the ion exchange membranes can be controlled by varying the ratio of olefin to cyclic olefin in the polymer backbone. |
| FILED | Monday, October 07, 2019 |
| APPL NO | 17/282512 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 210/02 (20130101) C08F 210/18 (20130101) C08F 2420/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2243 (20130101) Original (OR) Class C08J 2351/06 (20130101) Compositions of Macromolecular Compounds C08L 23/0823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380848 | Zhao et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanhe Zhao (Allston, Massachusetts); Hyunwoo Yuk (Cambridge, Massachusetts); Xiaoyu Chen (Cambridge, Massachusetts) |
| ABSTRACT | An adhesive material that provides fast and robust adhesion on wet surfaces, where the adhesion formed is detachable on-demand. The adhesive material is formed of one or more hydrophilic polymers or copolymers grafted with one or more amine coupling groups via a plurality of cleavable physical bonds and/or cleavable covalent bonds and one or more cross linkers. Application of the adhesive material on a wet surface causes the adhesive material to absorb liquid to thereby swell the adhesive material to form a layer of hydrogel, resulting in the formation of temporary crosslinks followed by covalent crosslinks with the surface. Introducing a triggering agent cleaves the cleavable physical bonds and/or cleavable covalent bonds to allow for non-traumatic detachment of the adhesive material from the surface. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/327944 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/0031 (20130101) A61L 24/0042 (20130101) A61L 24/043 (20130101) A61L 24/102 (20130101) Adhesives; Non-mechanical Aspects of Adhesive Processes in General; Adhesive Processes Not Provided for Elsewhere; Use of Materials as Adhesives C09J 7/32 (20180101) Original (OR) Class C09J 11/06 (20130101) C09J 151/003 (20130101) C09J 2301/10 (20200801) C09J 2301/306 (20200801) C09J 2301/414 (20200801) C09J 2301/502 (20200801) C09J 2433/00 (20130101) C09J 2451/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380934 | Savran et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cagri A. Savran (West Lafayette, Indiana); Rohil Jain (West Lafayette, Indiana); Chun-Li Chang (West Lafayette, Indiana) |
| ABSTRACT | The application relates to methods and systems for culturing individually selected cells in relative isolation from the rest of a population of cells, under physiologically relevant and controllable environmental conditions that can be designed to mimic specific environments, e.g., within a human body. |
| FILED | Thursday, April 08, 2021 |
| APPL NO | 17/225708 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) C12M 23/34 (20130101) C12M 41/48 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) Original (OR) Class C12N 5/0693 (20130101) C12N 5/0697 (20130101) C12N 2513/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380935 | Ogle et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Molly E. Ogle (Atlanta, Georgia); Gilad Doron (Atlanta, Georgia); Johnna S. Temenoff (Atlanta, Georgia) |
| ABSTRACT | Disclosed herein is a cell culture surface, comprising: a polymer material comprising an acrylate functional group; and one or more functional compounds comprising one or more functional moieties, at least one moiety from the one or more functional moieties configured to adhere to animal cells; wherein the cell culture surface has a compressive modulus between 10 kPa to 1000 kPa. Also disclosed herein are systems and methods for making and using the same. |
| FILED | Tuesday, October 08, 2019 |
| APPL NO | 17/283383 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) Original (OR) Class C12N 5/0663 (20130101) C12N 2533/20 (20130101) C12N 2533/30 (20130101) C12N 2533/50 (20130101) C12N 2533/70 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380948 | Lee et al. |
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| FUNDED BY |
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| APPLICANT(S) | Kelvin Lee (Newark, Delaware); Xiaolin Zhang (Iselin, New Jersey) |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware) |
| INVENTOR(S) | Kelvin Lee (Newark, Delaware); Xiaolin Zhang (Iselin, New Jersey) |
| ABSTRACT | The present invention provides a recombinant eukaryotic cell expressing one or more heterologous double strand break (DSB) repair proteins in an amount effective for enhancing DSB repair in the cell. The recombinant eukaryotic cell may express a recombinant product of interest. Also provided are methods for enhancing double strand break (DSB) repair in eukaryotic cells, establishing host cells for production of a recombinant product of interest, producing a recombinant product of interest, improving production of a recombinant product of interest by eukaryotic cells, and/or investigating suitability of eukaryotic cells as host cells for producing a recombinant product of interest. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407578 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0682 (20130101) Original (OR) Class C12N 9/88 (20130101) C12N 9/93 (20130101) C12N 2510/02 (20130101) C12N 2511/00 (20130101) Enzymes C12Y 402/99 (20130101) C12Y 605/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380983 | Voytas et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel F. Voytas (Falcon Heights, Minnesota); Paul Atkins (Roseville, Minnesota); Nicholas J. Baltes (Maple Grove, Minnesota) |
| ABSTRACT | Materials and methods for gene targeting using Clustered Regularly Interspersed Short Palindromic Repeats/CRISPR-associated (CRISPR/Cas) systems are provided herein. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405577 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 15/52 (20130101) C12N 15/1131 (20130101) Original (OR) Class C12N 15/8203 (20130101) C12N 15/8205 (20130101) C12N 15/8207 (20130101) C12N 15/8213 (20130101) C12N 2750/00043 (20130101) Enzymes C12Y 301/21 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381049 | Daugharthy et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan R. Daugharthy (Cambridge, Massachusetts); George M. Church (Brookline, Massachusetts) |
| ABSTRACT | The disclosure provides a method for detecting a target analyte in a biological sample including contacting the sample with one or more probe sets each comprising a primary probe and a linker, contacting the sample with an initiator sequence, contacting the sample with a plurality of fluorescent DNA hairpins, wherein the probe binds the target molecule, the linker connects the probe to the initiator sequence, and wherein the initiator sequence nucleates with the cognate hairpin and triggers self-assembly of tethered fluorescent amplification polymers, and detecting the target molecule by measuring fluorescent signal of the sample. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392325 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) C12N 2310/16 (20130101) C12N 2320/10 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6806 (20130101) C12Q 1/6816 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381116 | Kashi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Opus 12 Incorporated (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ajay R. Kashi (Berkeley, California); Aya K. Buckley (Berkeley, California); Sichao Ma (Dublin, California); Kendra P. Kuhl (Oakland, California); Sara Hunegnaw (Oakland, California) |
| ABSTRACT | Systems and methods for increasing the concentration of a desired product in gas phase output streams of COx electrolyzers are described. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/342406 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) Original (OR) Class C25B 9/23 (20210101) C25B 11/032 (20210101) C25B 11/042 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381819 | Jang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yoon-Soo Jang (Los Angeles, California); Chee Wei Wong (Los Angeles, California); Hao Liu (Los Angeles, California); Jinghui Yang (Los Angeles, California) |
| ABSTRACT | Systems and methods for soliton microcomb-based precision dimensional metrology via spectrally-resolved interferometry are described. In an embodiment, the system includes a dual-pumped soliton microcomb generator comprising a pump, a microresonator, and an auxiliary pump and that generates a single-soliton microcomb, an erbium-doped fiber amplifier that amplifies a C-band section of the soliton microcomb and a non-polarizing beam splitter that divides the soliton microcomb pulses into a reference arm pulse and a measurement arm pulse for an interferometer and recombines the reference arm pulse and the measurement arm pulse into a recombined beam upon their return. |
| FILED | Wednesday, November 06, 2019 |
| APPL NO | 17/287061 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02008 (20130101) Original (OR) Class Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/484 (20130101) G01S 17/36 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/06708 (20130101) H01S 3/06754 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382052 | Joung et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Hyou-Arm Joung (Los Angeles, California); Zachary S. Ballard (Los Angeles, California); Omai Garner (Los Angeles, California); Dino Di Carlo (Los Angeles, California); Aydogan Ozcan (Los Angeles, California) |
| ABSTRACT | A multiplexed vertical flow serodiagnostic testing device for diseases such as Lyme disease includes one or more multi-piece cassettes that include vertical stacks of functionalized porous layers therein. A bottom piece of the cassette includes a sensing membrane with a plurality of spatially multiplexed immunoreaction spots or locations. Top pieces are used to deliver sample and/or buffer solutions along with antibody-conjugated nanoparticles for binding with the immunoreaction spots or locations. A colorimetric signal is generated by the nanoparticles captured on the sensing membrane containing disease-specific antigens. The sensing membrane is imaged by a cost-effective portable reader device. The images captured by the reader device are subject to image processing and analysis to generate positive (+) or negative (−) indication for the sample. A concentration of one or more biomarkers may also be generated. The testing device is rapid, simple, inexpensive, and allows for simultaneous measurement of multiple antibodies and/or antigens making it an ideal point-of-care platform for disease diagnosis. |
| FILED | Friday, October 18, 2019 |
| APPL NO | 17/285906 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) Original (OR) Class G01N 2333/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382232 | He et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lingyan He (Cambridge, Massachusetts); Mian Zhang (Cambridge, Massachusetts); Amirhassan S. Ansari (Cambridge, Massachusetts); Marko Loncar (Cambridge, Massachusetts) |
| ABSTRACT | Low loss fiber-to-chip interfaces for lithium niobate photonic integrated circuits are provided. An optical circuit includes a waveguide comprising an electro-optical material. The waveguide includes an elevated ridge and a slab underlying the elevated ridge, the elevated ridge and the slab extending along a central axis toward an optical interface. The elevated ridge and the slab each have a plurality of cross-sections along the central axis, each cross-section having a width measured perpendicular to the central axis, wherein the width of elevated ridge is smaller than the width of the slab for every cross-section along the central axis. The elevated ridge includes a tapered portion having a first taper, wherein the cross-section of the elevated portion decreases along the central axis toward the optical interface. The slab includes a tapered portion having a second taper, wherein the cross-section of the slab decreases along the central axis toward the optical interface. The slab extends beyond the elevated ridge along the central axis to the optical interface. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407856 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/14 (20130101) G02B 6/305 (20130101) G02B 6/1228 (20130101) Original (OR) Class G02B 6/12004 (20130101) G02B 2006/1204 (20130101) G02B 2006/12061 (20130101) G02B 2006/12097 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382371 | Ni et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingjie Ni (State College, Pennsylvania); Xuexue Guo (State College, Pennsylvania); Yimin Ding (State College, Pennsylvania); Yao Duan (State College, Pennsylvania); Xi Chen (State College, Pennsylvania) |
| ABSTRACT | Embodiments relate to a photonic component having a metasurface. The metasurface includes a substrate with a thin-layer of meta-atoms disposed thereon. The photonic component includes a waveguide having a top surface, wherein the metasurface is disposed on at least a portion of the top surface such that the meta-atoms form an array on the top surface. The photonic component includes a sandwich nano-bar antenna formed in or on the metasurface. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/303741 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/2955 (20130101) Original (OR) Class G02F 2202/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382479 | Haghani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Insurance Services Office, Inc. (Jersey City, New Jersey); University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | Insurance Services Office, Inc. (Jersey City, New Jersey); University of Southern California (Los Angeles, California) |
| INVENTOR(S) | Naveed Haghani (Fulton, Maryland); Jiaoyang Li (Jiangsu, China PRC); Sven Koenig (Pasadena, California); Gautam Kunapuli (Brooklyn, New York); Claudio Contardo (Montreal (PQ), Canada); Julian Yarkony (Jersey City, New Jersey) |
| ABSTRACT | Systems and methods for controlling automated systems, such as robots and other devices/resources, using integer programming and column generation techniques, are provided. The system retrieves location and movement data corresponding to at least one automated system, and processes the location and movement data using an integer linear programming algorithm. The system also optimizes the integer linear programming algorithm using a column generation algorithm, and solves a pricing problem associated with generating routes for the at least one automated system. Then, the system generates a route based on outputs of the integer linear programming algorithm, the column generation algorithm, and solving of the pricing problem, and transmits the route to the at least one automated system, the at least one automated system executing the route to control a location or a movement of the at least one automated system. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343612 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3453 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/042 (20130101) G05B 2219/2637 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) Original (OR) Class G05D 1/0212 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382696 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianhua Yang (Hadley, Massachusetts); Qiangfei Xia (Amherst, Massachusetts); Hao Jiang (Sunderland, Massachusetts) |
| ABSTRACT | A true random number generator device based on a diffusive memristor is disclosed. The random number generator device includes a diffusive memristor driven by a pulse generator circuit. The diffusive memristor produces a stochastically switched output signal. A comparator circuit receives the stochastically switched output signal from the diffusive memristor and generates an output signal having a random pulse width. An AND gate logic circuit is driven by a clock signal and the output signal from the comparator circuit. The AND gate logic circuit produces a combined output signal. A counter circuit receives the combined output signal from the AND gate logic circuit and generates a random bit string output signal. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407587 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/588 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 45/085 (20130101) H01L 45/146 (20130101) H01L 45/1253 (20130101) H01L 45/1266 (20130101) Pulse Technique H03K 3/84 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383201 | Gu |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Gu (Evanston, Illinois) |
| ABSTRACT | Systems and/or methods may include an edge-computing distributed neural processor to effectively reduce the data traffic and physical wiring congestion. A local and global networking architecture may reduce traffic among multi-chips in edge computing. A mixed-signal feature extraction approach with assistance of neural network distortion recovery is also described to reduce the silicon area. High precision in signal features classification with a low bit processing circuitry may be achieved by compensating with a recursive stochastic rounding routine, and provide on-chip learning to re-classify the sensor signals. |
| FILED | Monday, October 21, 2019 |
| APPL NO | 17/286330 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/486 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/72 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) G06K 9/6289 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/063 (20130101) Original (OR) Class G06N 3/0472 (20130101) Static Stores G11C 11/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383512 | Oldham et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenn Oldham (Ann Arbor, Michigan); Thomas D. Wang (Ann Arbor, Michigan); Mayur Bhushan Birla (Ann Arbor, Michigan); Xiyu Duan (San Jose, California) |
| ABSTRACT | A computer-implemented method includes receiving a raw data set representing an image of a sample, identifying a first set of extremum by analyzing the raw data set using a metric algorithm, identifying a second set of extremum by analyzing the first set of extremum, and generating, based on the second set of extremum, a reconstructed image of the sample. A phase correcting scanner includes one or more processors, one or more scanner adapted to sequentially sample an object to generate a vector of raw data representing the object in a Lissajous pattern, and memory storing instructions that, when executed by the one or more processors, cause the computing system to receive the vector of raw data, identify a first set of extremum by analyzing the raw data set using a metric algorithm, and identify a second set of extremum by analyzing the first set of extremum. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 17/288886 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/003 (20130101) Original (OR) Class G06T 7/0012 (20130101) G06T 2207/10068 (20130101) G06T 2207/30004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383682 | GUERIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelleher GUERIN (Baltimore, Maryland); Gregory HAGER (Baltimore, Maryland) |
| ABSTRACT | Provided is a method, device, and computer-readable medium for controlling a robot graphic user interface (“RGUI”) on a mobile device. The method can include determining a distance, a position, or both of the mobile device with respect to a first robot; and causing, by a processor, a first RGUI to be displayed on a display of the mobile device based on the determining. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406589 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/409 (20130101) G05B 2219/39384 (20130101) G05B 2219/40382 (20130101) Transmission Systems for Measured Values, Control or Similar Signals G08C 17/02 (20130101) Original (OR) Class G08C 2201/20 (20130101) G08C 2201/30 (20130101) G08C 2201/70 (20130101) G08C 2201/91 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210383717 — METHOD OF INCREMENTAL TRAINING TO CREATE NEW PATTERNS OF PHYSIOLOGICAL CONTROL SIGNALS
| US 20210383717 | Oby et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania); UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emily R. Oby (Pittsburgh, Pennsylvania); Aaron P. Batista (Pittsburgh, Pennsylvania); Steven M. Chase (Pittsburgh, Pennsylvania); Alan D. Degenhart (Pittsburgh, Pennsylvania); Matthew D. Golub (Stanford, California); Patrick T. Sadtler (Pittsburgh, Pennsylvania); Byron M. Yu (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein is a method for training a subject to produce a new neural activity pattern that results in a desired behavior. The method creates a brain-computer interface mapping between a neural activity pattern of a set of neural units and the desired behavior in an intrinsic manifold, without learning. An outside manifold perturbation of the mapping is then created, defining a new neural activity pattern lying outside of the intrinsic manifold that will produce the desired behavior. The new neural activity pattern is taught by incrementally perturbing the neural activity pattern that produces the desired behavior between the intrinsic manifold and the outside manifold perturbation and having the subject learn the desired behavior for each increment. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343050 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/372 (20210101) A61B 2505/09 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 19/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384362 | Li et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Wenshen Li (Ithaca, New York); Zongyang Hu (Ithaca, New York); Kazuki Nomoto (Ithaca, New York); Debdeep Jena (Ithaca, New York); Huili Grace Xing (Ithaca, New York) |
| ABSTRACT | Described herein are the design and fabrication of Group III trioxides, such as β-Ga2O3, trench-MOS barrier Schottky (TMBS) structures with high voltage (>1 kV), low leakage capabilities, while addressing on the necessary methods to meet the re-quirements unique to Group III trioxides, such as β-Ga2O3. |
| FILED | Wednesday, October 30, 2019 |
| APPL NO | 17/291689 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) H01L 29/36 (20130101) H01L 29/407 (20130101) H01L 29/8725 (20130101) Original (OR) Class H01L 29/66969 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384504 | Liang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| INVENTOR(S) | Xinhua Liang (Rolla, Missouri); Yan Gao (Rolla, Missouri) |
| ABSTRACT | The present invention relates to various lithium ion battery cathodes as well as lithium ion batteries incorporating one or more of these cathodes. The present invention further relates to processes of preparing the lithium ion battery cathode. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337641 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0428 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384762 | Isobe et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Hiroki Isobe (Cambridge, Massachusetts); Qiong MA (Allston, Massachusetts); Liang FU (Winchester, Massachusetts); Nuh GEDIK (Watertown, Massachusetts); Suyang XU (Allston, Massachusetts); Pablo Jarillo-Herrero (Cambridge, Massachusetts) |
| ABSTRACT | Rectification is a process that converts electromagnetic fields into direct current (DC). Such a process underlies a wide range of technologies, including wireless communication, wireless charging, energy harvesting, and infrared detection. Existing rectifiers are mostly based on semiconductor diodes, with limited applicability to small voltages or high frequency inputs. Here, we present an alternative approach to current rectification that uses the electronic properties of quantum crystals without semiconductor junctions. We identify a new mechanism for rectification from skew scattering due to the chirality of itinerant electrons in time-reversal-invariant but inversion-breaking materials. Our calculations reveal large, tunable rectification effects in graphene multilayers and transition metal dichalcogenides. These effects can be used in high-frequency rectifiers by rational material design and quantum wavefunction engineering. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345078 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/001 (20200101) Original (OR) Class H02J 50/27 (20160201) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/4208 (20130101) H02M 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384887 | MORTAZAWI et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Amir MORTAZAWI (Ann Arbor, Michigan); Milad ZOLFAGHARLOO KOOHI (Ann Arbor, Michigan) |
| ABSTRACT | Bulk acoustic wave resonators are presented. Such resonators typically operate based on a dynamic nonuniform effective piezoelectricity in composite multilayer ferroelectrics with large electrostriction coefficients, like barium strontium titanate (BST). Harmonic resonance modes of a multilayer bulk acoustic wave resonator can be selectively excited with an electromechanical coupling coefficient equal to the fundament mode, which is contrary to the trend K2∝1/n2 exhibited by conventional piezoelectric bulk acoustic resonators. Such a resonator allows for the design of a new class of band-switching filters. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237215 |
| CURRENT CPC | Impedance Networks, e.g Resonant Circuits; Resonators H03H 3/02 (20130101) H03H 9/131 (20130101) H03H 9/205 (20130101) Original (OR) Class H03H 9/0211 (20130101) H03H 9/605 (20130101) H03H 9/02015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210379559 | Weston et al. |
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| FUNDED BY |
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| APPLICANT(S) | NuMat Technologies Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | NUMAT TECHNOLOGIES INC. (Skokie, Illinois) |
| INVENTOR(S) | Mitchell Hugh Weston (Chicago, Illinois); William Morris (Chicago, Illinois); William Joseph Hoover (Chicago, Illinois); Patrick Emmett Fuller (Chicago, Illinois); John Paul Siegfried (Chicago, Illinois); Randi Danielle Groy (Chicago, Illinois); Jeffrey Loren Wells (Chicago, Illinois); Timothy Chiaan Wang (Milwaukee, Wisconsin); Edwin Alfonso Argueta Fajardo (Chicago, Illinois) |
| ABSTRACT | This invention relates to modified MOF materials, methods of preparing them and processes using them. A modified MOF of the invention is modified by impregnating a MOF with an inorganic metal salt. The starting MOF contains at least one linker or ligand which contains an aryl amino group as part of its structure. These modified MOFs are able to adsorb either basic or acidic toxic industrial compounds (TIC). The modified MOFs can be used to remove TICs from various gaseous streams such as air. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217793 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/11 (20130101) Separation B01D 53/04 (20130101) B01D 2253/204 (20130101) B01D 2257/404 (20130101) B01D 2257/406 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/2804 (20130101) B01J 20/3202 (20130101) B01J 20/3265 (20130101) Non-metallic Elements; Compounds Thereof; C01B 37/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379638 | Whalen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (, None) |
| INVENTOR(S) | Scott A. Whalen (West Richland, Washington); Darrell R. Herling (Kennewick, Washington); Xiao Li (Richland, Washington); MD. Reza-E-Rabby (Richland, Washington); Brandon Scott Taysom (West Richland, Washington); Glenn J. Grant (Benton City, Washington); Vineet V. Joshi (Richland, Washington); Rajib Kalsar (Richland, Washington); Tianhao Wang (Richland, Washington) |
| ABSTRACT | The present disclosure provides methods for preparing an extruded product from a solid billet. The methods can include providing an as-cast billet for extrusion; applying a simultaneous rotational shear and axial extrusion force to the as-cast billet to plasticize the as-cast billet; and extruding the plasticized as-cast billet with an extrusion die to form an extruded product. Methods for preparing extruded products from billets can also include: providing a billet for extrusion; while maintaining a majority of the billet below 100° C., applying a simultaneous rotational shear and axial extrusion force to one end of the billet to plasticize the one end of the billet; and extruding the plasticized one end of the billet with an extrusion die to form an extruded product. Methods for preparing an extruded product from a billet can also include providing a billet for extrusion; applying a simultaneous rotational shear and axial extrusion force to the billet to plasticize the billet; extruding the plasticized billet with an extrusion die to form an extruded product; and artificially aging the extruded product for less than the ASTM recommended amount of time. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/242166 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/218 (20130101) Original (OR) Class Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 37/16 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 20/001 (20130101) B23K 2103/10 (20180801) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/04 (20130101) C22F 1/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380249 | Pearson et al. |
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| FUNDED BY |
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| APPLICANT(S) | B/E Aerospace, Inc. (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew R. Pearson (Hartford, Connecticut); Piyush Agrawal (South Windsor, Connecticut) |
| ABSTRACT | A passenger service unit health monitoring system includes a cardiorespiratory sensor unit, a temperature sensor, and one or more controllers having one or more processors configured to execute a set of program instructions maintained in one or more memory units, wherein the set of program instructions is configured to cause the one or more processors to: receive one or more signals from at least one of the temperature sensor or the cardiorespiratory sensor unit indicative of one or more physiological states of the subject; measure one or more physiological states of the subject based on the one or more signals indicative of one or more physiological states of the subject; determine one or more physiological interventions based on the one or more physiological states of the subject; and transmit one or more signals instructive of the one or more physiological interventions. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/340323 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/05 (20130101) A61B 5/02055 (20130101) A61B 5/6887 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 11/00 (20130101) Original (OR) Class Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380400 | Leber et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Moritz Leber (Salt Lake City, Utah); Florian Solzbacher (Salt Lake City, Utah); Brian Baker (Salt Lake City, Utah) |
| ABSTRACT | A membrane based microelectronic device (200) can include a printed circuit board (202), a polymer film (210) laminated onto the circuit board, and one or more microelectromechanical components (208) integrated into the printed circuit board (202). At least a portion of the polymer film (210) forms a membrane element of the one or more microelectromechanical components (208). |
| FILED | Thursday, September 19, 2019 |
| APPL NO | 17/277563 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0021 (20130101) Original (OR) Class B81B 2201/0214 (20130101) B81B 2201/0264 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00182 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380405 | HUNYADI MURPH et al. |
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| FUNDED BY |
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| APPLICANT(S) | SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SIMONA E. HUNYADI MURPH (North Augusta, South Carolina); Vahid Majidi (Aiken, South Carolina) |
| ABSTRACT | Methods and systems for high-speed production of nanoparticles with very high product yields are described. Systems utilize concentric micro-scale capillaries arranged to define nanoparticle formation regions that lie along predetermined length(s) of the capillaries. Flow through the formation regions can be laminar during a formation protocol. The system can include on-line analytical tools for real time characterization of products or intermediates. Systems include an additive manufacturing-type deposition at the terminus of the formation section. The deposition area includes a print head and a print bed and provides for random or patterned deposition of nanoparticles. The print head and/or the print bed can be capable of motion in one or more degrees of freedom relative to one another. |
| FILED | Thursday, June 04, 2020 |
| APPL NO | 16/892711 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/314 (20170801) B29C 64/321 (20170801) Nanostructures Formed by Manipulation of Individual Atoms, Molecules, or Limited Collections of Atoms or Molecules as Discrete Units; Manufacture or Treatment Thereof B82B 3/0004 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380456 | Visco et al. |
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| FUNDED BY |
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| APPLICANT(S) | PolyPlus Battery Company (Berkeley, California) |
| ASSIGNEE(S) | PolyPlus Battery Company (Berkeley, California) |
| INVENTOR(S) | Steven J. Visco (Berkeley, California); Yevgeniy S. Nimon (Danville, California); Bruce D. Katz (Moraga, California) |
| ABSTRACT | Li ion conductive sulfide glass, can be made by providing a pre-mix of precursor materials for making the Li ion conductive sulfide glass, providing a melting tank for processing the pre-mix to a molten state, and heating the melting tank to a temperature that is sufficient to melt form the Li ion conductive sulfide glass, wherein the melting tank is a metal vessel having inner wall surfaces that are coated with a corrosion resistant metal oxide layer. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/301453 |
| CURRENT CPC | Manufacture, Shaping, or Supplementary Processes C03B 5/04 (20130101) C03B 5/43 (20130101) Original (OR) Class C03B 17/06 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 50/406 (20210101) H01M 50/437 (20210101) H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380567 | PAQUETTE et al. |
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| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania); The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia); Rowan University (Mullica Hill, New Jersey) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania); The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia); Rowan University (Mullica Hill, New Jersey) |
| INVENTOR(S) | Craig Michael PAQUETTE (Ambler, Pennsylvania); John Joseph LA SCALA (Wilmington, Delaware); Joshua Matthew SADLER (Parkville, Maryland); Giuseppe Rafaello PALMESE (Hainesport, New Jersey); Alexander William BASSETT (Mullica Hill, New Jersey); Joseph Francis STANZIONE (Wilmington, Delaware) |
| ABSTRACT | A composition of matter including two optionally substituted phenol or optionally substituted aniline units separated by a furan spacer has been prepared. In particular, the chemical structure has a novolac bridge between the central furan ring and the two attached optionally substituted phenol and/or optionally substituted aniline units. These compounds can be modified to be used in various polymer resins. This new structure reduces toxicity relative to BPA/F, makes use of renewable chemicals, and produces certain beneficial polymer properties. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 17/284032 |
| CURRENT CPC | Heterocyclic Compounds C07D 307/42 (20130101) C07D 407/14 (20130101) Original (OR) Class Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 222/20 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 59/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380771 | BAE et al. |
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| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Chulsung BAE (Cohoes, New York); Jong Yeob JEON (Troy, New York) |
| ABSTRACT | Ion exchange membranes for use in electrochemical energy conversion and storage applications include copolymers having a backbone produced from an olefin, such as ethylene, and a cyclic olefin, such as norbornene. Haloalkyl side chains with terminal halide groups are connected to the polymer backbone via Friedel-Crafts alkylation. The halide groups are then replaced with ionic groups via substitution. The ion exchange membrane material can then be cast or impregnated into a reinforcing mesh to form cation exchange membrane or anion exchange membranes. Rigidity of the ion exchange membranes can be controlled by varying the ratio of olefin to cyclic olefin in the polymer backbone. |
| FILED | Monday, October 07, 2019 |
| APPL NO | 17/282512 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 210/02 (20130101) C08F 210/18 (20130101) C08F 2420/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2243 (20130101) Original (OR) Class C08J 2351/06 (20130101) Compositions of Macromolecular Compounds C08L 23/0823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380861 | ODUKOMAIYA et al. |
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| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adewale ODUKOMAIYA (Denver, Colorado); Erin Lynn BLACKLEY (Colorado Springs, Colorado); Jason David WOODS (Boulder, Colorado); Judith Cecilia VIDAL (Littleton, Colorado); Shuang CUI (Denver, Colorado) |
| ABSTRACT | Among other things, the present disclosure relates to phase change material (PCM) composites composed of an PCM mixed with a nucleating agent contained within the pores of a graphite matrix and/or a hydrogel. The process to create these PCM composites includes coating the surface of graphite with a surfactant, compressing the graphite to form a matrix, then filling the graphite matrix with the PCM. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337757 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/063 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380963 | Leang |
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| FUNDED BY |
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| APPLICANT(S) | LanzaTech, Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ching Leang (Skokie, Illinois) |
| ABSTRACT | Provided herein is a genetically engineered microorganism comprising knock-in of DNA at an acetolactate decarboxylase gene locus. Replacement of the acetolactate decarboxylase gene with DNA encoding one or more native or nonnative enzymes confers certain advantages, including fermentation stability and increased production of native and nonnative products from gaseous substrates. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/303677 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/13 (20130101) C12N 9/88 (20130101) Original (OR) Class C12N 9/1029 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/007 (20130101) C12P 5/026 (20130101) C12P 7/04 (20130101) C12P 7/18 (20130101) C12P 7/26 (20130101) C12P 7/30 (20130101) C12P 7/42 (20130101) C12P 7/6409 (20130101) Enzymes C12Y 208/03 (20130101) C12Y 401/01001 (20130101) C12Y 401/01005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381115 | Kang et al. |
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| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Donghyeon Kang (Willowbrook, Illinois); Edward F. Barry (Chicago, Illinois); John N. Hryn (Hawthorn Woods, Illinois) |
| ABSTRACT | Methods and systems for scalable production of lithium metal through electrodeposition. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 16/894210 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/14 (20130101) Original (OR) Class Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381116 | Kashi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Opus 12 Incorporated (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ajay R. Kashi (Berkeley, California); Aya K. Buckley (Berkeley, California); Sichao Ma (Dublin, California); Kendra P. Kuhl (Oakland, California); Sara Hunegnaw (Oakland, California) |
| ABSTRACT | Systems and methods for increasing the concentration of a desired product in gas phase output streams of COx electrolyzers are described. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/342406 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) Original (OR) Class C25B 9/23 (20210101) C25B 11/032 (20210101) C25B 11/042 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381585 | Crawford |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony Crawford (Rigby, Idaho) |
| ABSTRACT | Apparatuses and methods of operating a linear differential (100, 600) are described herein. The linear differential (100, 600) contains a slide portion (102) with parallel right-hand and left-hand threaded rods (112, 114). Threaded onto the right-hand and left-hand threaded rods (112, 114) and attached to the slide portion (102) are right-hand and left-hand gears (116, 118). Meshed between the right-hand and left-hand gears (116, 118) and also attached to the slide portion (102) is a driven gear (200). An end effector (104) is attached to the driven gear (200) and is configured to translate along a translation axis (110) and rotate around a rotation axis (120). |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 16/892081 |
| CURRENT CPC | Turning; Boring B23B 39/00 (20130101) Gearing F16H 25/2025 (20130101) F16H 37/16 (20130101) Original (OR) Class F16H 2025/2053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381986 | Doughty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin L. Doughty (Knoxville, Tennessee); Yingzhong Ma (Oak Ridge, Tennessee) |
| ABSTRACT | A system is provided. The system has a femtosecond oscillator to generate pulses used for pump and probe beams. A photonic crystal fiber is disposed in a path of the probe beam and produces pulses for a chirped probe beam. A high NA objective receives the pump and the chirped probe beam, redirects the received beams through a dielectric substrate towards an interface between a sample and the dielectric substrate to cause total internal reflection (TIR) at the sample-substrate interface, and produces corresponding evanescent waves in a portion of the sample adjacent to the sample-substrate interface, and collects a backward-propagating beam of pulses of responsive light. The portion of the sample illuminated by the evanescent waves emits responsive light. The dielectric substrate is transparent to the responsive light, the pump and the chirped probe beam. An image is produced having a specific image size using the received backward-propagating beam. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240514 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/211 (20130101) G01N 21/636 (20130101) G01N 21/658 (20130101) Original (OR) Class G01N 2021/212 (20130101) G01N 2021/656 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381992 | Aguiar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey A. Aguiar (Sait Lake City, Utah) |
| ABSTRACT | A material identification system includes one or more data interfaces configured to receive first sensor data generated by a first sensor responsive to a material sample, and receive second sensor data generated by a second sensor responsive to the material sample. The material identification system also includes one or more processors configured to generate a set of predictions of an identification of the material sample and a corresponding set of certainty information. |
| FILED | Wednesday, October 23, 2019 |
| APPL NO | 17/309074 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/20058 (20130101) Original (OR) Class G01N 2223/418 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/28 (20130101) H01J 2237/2802 (20130101) H01J 2237/2804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382130 | Rouse et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerry W. Rouse (Albuquerque, New Mexico); Daniel Bowman (Albuquerque, New Mexico); Timothy Walsh (West Lafayette, Indiana) |
| ABSTRACT | A method and apparatus for determining a direction of infrasound. Infrasound is received by a directional infrasound sensor comprising a plurality of channels and a plurality of sensor devices. Each channel in the plurality of channels comprises a single opening at a first end of the channel and a closed end opposite the opening. The opening of each channel in the plurality of channels is pointed in a different direction from the opening of each other channel in the plurality of channels. The plurality of sensor devices includes a sensor device at the closed end of each channel in the plurality of channels. Each sensor device in the plurality of sensor devices is configured to generate a sensor signal in response to pressure. The sensor signals generated by the plurality of sensor devices are processed to determine the direction of the infrasound received by the directional infrasound sensor. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 16/893675 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 3/801 (20130101) G01S 3/8006 (20130101) Original (OR) Class G01S 3/8034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382718 | Agrawal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Varun Agrawal (Acton, Massachusetts); John Kalamatianos (Arlington, Massachusetts) |
| ABSTRACT | An electronic device includes a processor, a branch predictor in the processor, and a predictor controller in the processor. The branch predictor includes multiple prediction functional blocks, each prediction functional block configured for generating predictions for control transfer instructions (CTIs) in program code based on respective prediction information, the branch predictor configured to select, from among predictions generated by the prediction functional blocks for each CTI, a selected prediction to be used for that CTI. The predictor controller keeps a record of prediction functional blocks from which the branch predictor previously selected predictions for CTIs. The predictor controller uses information from the record for controlling which prediction functional blocks are used by the branch predictor for generating predictions for CTIs. |
| FILED | Monday, June 08, 2020 |
| APPL NO | 16/895825 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3806 (20130101) G06F 9/30032 (20130101) Original (OR) Class G06F 9/30058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210383944 | Graber et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lukas Graber (Atlanta, Georgia); Chanyeop Park (Starkville, Mississippi); Jia Wei (Atlanta, Georgia) |
| ABSTRACT | A dielectric material with heat transfer properties includes a first fluid and a second fluid different from the first fluid and miscible with the first fluid. The first fluid and the second fluid are mixed with each other so as to form a mixture and are kept at a temperature and a pressure so that the mixture is maintained in a supercritical phase. The mixture has at least one parameter that is preferably different from a corresponding parameter in both a supercritical phase of the first fluid and a supercritical phase of the second fluid. In a method of insulating electrical contacts and removing heat therefrom, the mixture is disposed about the electrical contacts and is maintained at a temperature and at a pressure that causes the mixture to be in a supercritical phase so that the mixture has favorable dielectric and heat transfer properties. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407829 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 3/002 (20130101) H01B 3/16 (20130101) Original (OR) Class H01B 17/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384021 | Ovchinnikova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Olga S. Ovchinnikova (Oak Ridge, Tennessee); Anton V. Ievlev (Oak Ridge, Tennessee); Matthias Lorenz (Toronto, Canada); Nikolay Borodinov (Newtown, Pennsylvania); Steven T. King (Hempstead, New York) |
| ABSTRACT | Machine learning approach can combine mass spectral imaging (MSI) techniques, one with low spatial resolution but intact molecular spectra and the other with nanometer spatial resolution but fragmented molecular signatures, to predict molecular MSI spectra with submicron spatial resolution. The machine learning approach can perform transformations on the spectral image data of the two MSI techniques to reduce dimensionality, and using a correlation technique, find relationships between the transformed spectral image data. The determined relationships can be used to generate MSI spectra of desired resolution. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337919 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/2258 (20130101) G01N 2223/07 (20130101) G01N 2223/40 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Electric Discharge Tubes or Discharge Lamps H01J 49/0004 (20130101) H01J 49/0036 (20130101) Original (OR) Class H01J 49/164 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384493 | Pintauro et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter N. Pintauro (Brentwood, Tennessee); Ryszard N. Wycisk (Nashville, Tennessee) |
| ABSTRACT | A composite electrode includes two or more types of fibers forming a fiber network, comprising at least a first type of fibers and a second type of fibers. The first type of fibers comprises a first polymer and a first type of particles. The second type of fibers comprises a second polymer and a second type of particles. The second polymer is same as or different from the first polymer. The second type of particles are same as or different from the first type of particles. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/341487 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0007 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 11/74 (20130101) D06M 11/77 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/0419 (20130101) H01M 4/623 (20130101) H01M 4/625 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384494 | Yao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhenpeng Yao (Skokie, Illinois); Christopher M. Wolverton (Wilmette, Illinois) |
| ABSTRACT | Calcium ion batteries are provided. The calcium ion batteries include a cathode, an alloying anode composed of one or more intermetallic calcium compounds in electrical communication with the cathode; and an electrolyte disposed between the anode and the cathode. The intermetallic calcium compounds are intermetallic compounds of calcium and transition metals and metalloids. |
| FILED | Tuesday, October 22, 2019 |
| APPL NO | 17/287459 |
| CURRENT CPC | Alloys C22C 24/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/381 (20130101) Original (OR) Class H01M 10/054 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384506 | Tong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei Tong (Albany, California); Ning Li (El Cerrito, California); Meiling Sun (Oakland, California); Jing Xu (Mountain View, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to cathode materials for lithium ion batteries. In one aspect, a structure comprises an oxide including lithium and two or more transition metals. A first portion of the oxide is in a layered phase and a second portion of the oxide is in a rocksalt phase. The first potion of the oxide and the second portion of the oxide form a layered-rocksalt intergrown structure. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/339651 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 4/1391 (20130101) H01M 10/0525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384586 | Carlson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Optodot Corporation (Devens, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. Carlson (Cambridge, Massachusetts); Ifenna Kingsley Anakor (Allston, Massachusetts); Greg Robert Farrell (Sudbury, Massachusetts) |
| ABSTRACT | Provided are separators for use in an electrochemical cell comprising (a) an inorganic oxide and (b) an organic polymer, wherein the inorganic oxide comprises organic substituents. Also provided are electrochemical cells comprising such separators. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406515 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/303 (20130101) C04B 24/00 (20130101) C04B 24/023 (20130101) C04B 26/06 (20130101) C04B 38/0074 (20130101) C04B 2111/00612 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 50/409 (20210101) H01M 50/411 (20210101) H01M 50/431 (20210101) H01M 50/446 (20210101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 29/49115 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210384762 | Isobe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Hiroki Isobe (Cambridge, Massachusetts); Qiong MA (Allston, Massachusetts); Liang FU (Winchester, Massachusetts); Nuh GEDIK (Watertown, Massachusetts); Suyang XU (Allston, Massachusetts); Pablo Jarillo-Herrero (Cambridge, Massachusetts) |
| ABSTRACT | Rectification is a process that converts electromagnetic fields into direct current (DC). Such a process underlies a wide range of technologies, including wireless communication, wireless charging, energy harvesting, and infrared detection. Existing rectifiers are mostly based on semiconductor diodes, with limited applicability to small voltages or high frequency inputs. Here, we present an alternative approach to current rectification that uses the electronic properties of quantum crystals without semiconductor junctions. We identify a new mechanism for rectification from skew scattering due to the chirality of itinerant electrons in time-reversal-invariant but inversion-breaking materials. Our calculations reveal large, tunable rectification effects in graphene multilayers and transition metal dichalcogenides. These effects can be used in high-frequency rectifiers by rational material design and quantum wavefunction engineering. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345078 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/001 (20200101) Original (OR) Class H02J 50/27 (20160201) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/4208 (20130101) H02M 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210379661 | Hofmann |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Douglas C. Hofmann (Altadena, California) |
| ABSTRACT | Methods and alloy systems for non-Be BMG matrix composite materials that can be used to additively manufacturing parts with superior mechanical properties, especially high toughness and strength, are provided. Alloys are directed to BMGMC materials comprising a high strength BMG matrix reinforced with properly scaled, soft, crystalline metal dendrite inclusions dispersed throughout the matrix in a sufficient concentration to resist fracture. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405836 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/10 (20210101) Original (OR) Class B22F 2301/205 (20130101) B22F 2999/00 (20130101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/0093 (20130101) B23K 26/342 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/00 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) Alloys C22C 1/0458 (20130101) C22C 16/00 (20130101) C22C 33/0278 (20130101) C22C 38/002 (20130101) C22C 38/02 (20130101) C22C 38/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382164 | Bayer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mustafa Mert Bayer (Irvine, California); Ozdal Boyraz (Irvine, California) |
| ABSTRACT | Various examples for multi-tone continuous wave detection and ranging are disclosed herein. In some embodiments, an initial signal is generated using initial radio frequency (RF) tones, and is emitted as a multi-tone continuous wave signal. The initial signal is reflected from a target and received as a reflected signal. Resultant RF tones, including a frequency, a phase and a power, are determined from the reflected signal in a frequency domain. A frequency-domain sinusoidal wave is fitted to the resultant RF tones in the frequency domain, and a distance to the target is determined using a modulation of the frequency-domain sinusoidal wave. A phase processing algorithm is applied to generate the target distance and speed by triangulating the range information encoded in the backscattered RF tones. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/409076 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 3/00 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4814 (20130101) G01S 13/06 (20130101) G01S 13/584 (20130101) Original (OR) Class G01S 17/06 (20130101) G01S 17/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382371 | Ni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingjie Ni (State College, Pennsylvania); Xuexue Guo (State College, Pennsylvania); Yimin Ding (State College, Pennsylvania); Yao Duan (State College, Pennsylvania); Xi Chen (State College, Pennsylvania) |
| ABSTRACT | Embodiments relate to a photonic component having a metasurface. The metasurface includes a substrate with a thin-layer of meta-atoms disposed thereon. The photonic component includes a waveguide having a top surface, wherein the metasurface is disposed on at least a portion of the top surface such that the meta-atoms form an array on the top surface. The photonic component includes a sandwich nano-bar antenna formed in or on the metasurface. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/303741 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/2955 (20130101) Original (OR) Class G02F 2202/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210382468 | Weathers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOEING COMPANY (Chicago, Illinois) |
| ASSIGNEE(S) | THE BOEING COMPANY (CHICAGO, Illinois) |
| INVENTOR(S) | James B. Weathers (Huntsville, Alabama); Jeffrey W. Weathers (Huntsville, Alabama) |
| ABSTRACT | A system and method include a simulation control unit configured to receive structural data regarding a structure to be formed. The simulation control unit performs a virtual forming simulation to determine a feasibility of forming the structure based on the structural data. In response to the simulation control unit determining that the structure can be feasibly formed based on the structural data, the simulation control unit outputs a forming plan for forming the structure based on the structural data. |
| FILED | Thursday, June 04, 2020 |
| APPL NO | 16/892339 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/66 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4183 (20130101) G05B 19/4188 (20130101) G05B 19/41885 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20210380991 | Jacobson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Gen9, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Gen9, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Joseph Jacobson (Newton, Massachusetts); Daniel Schindler (Newton Upper Falls, Massachusetts); Scott S. Lawton (Bedford, Massachusetts) |
| ABSTRACT | Aspects of the invention relate to methods, compositions and algorithms for designing and producing a target nucleic acid. The method can include: (1) providing a plurality of blunt-end double-stranded nucleic acid fragments having a restriction enzyme recognition sequence at both ends thereof; (2) producing via enzymatic digestion a plurality of cohesive-end double-stranded nucleic acid fragments each having two different and non-complementary overhangs; (3) ligating the plurality of cohesive-end double-stranded nucleic acid fragments with a ligase; and (4) forming a linear arrangement of the plurality of cohesive-end double-stranded nucleic acid fragments, wherein the unique arrangement comprises the target nucleic acid. In certain embodiments, the plurality of blunt-end double-stranded nucleic acid fragments can be provided by: releasing a plurality of oligonucleotides synthesized on a solid support; and synthesizing complementary strands of the plurality of oligonucleotides using a polymerase based reaction. |
| FILED | Monday, July 12, 2021 |
| APPL NO | 17/373324 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/66 (20130101) Original (OR) Class C12N 15/1027 (20130101) C12N 15/1031 (20130101) C12N 15/1089 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 2521/301 (20130101) C12Q 2521/501 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 30/00 (20190201) G16B 30/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210381883 | Gaitan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Gaitan (North Potomac, Maryland); Jon Clement Geist (Olney, Maryland); Benjamin James Reschovsky (Cabin John, Maryland); Akobuije Douglas Eziani Chijioke (Silver Spring, Maryland) |
| ABSTRACT | A calibration apparatus for calibrating a laser Doppler vibrometer includes: a frequency shifter stage that: receives, from the laser Doppler vibrometer, primary laser light; produces frequency shifted light; communicates the frequency shifted light to a reflector; receives frequency shifted light reflected by the reflector; produces secondary light; and communicates the secondary light to the laser Doppler vibrometer, such that the laser Doppler vibrometer receives the secondary light from the frequency shifter stage and produces a synthetic velocity shift from the secondary light; and the reflector that receives and reflects the frequency shifted light back to the frequency shifter stage. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336964 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210385664 | Nguyen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thao Tran-Nhu Nguyen (McLean, Virginia); Michael Rafat Souryal (Arlington, Virginia) |
| ABSTRACT | Systems and methods for independently managing wireless transmission by individual spectrum access systems in a radio frequency spectrum shared by a plurality of spectrum access systems. An example method includes: receiving, by the spectrum access system, an interference budget from a sensor; determining, by the spectrum access system, secondary users managed by the spectrum access system in a radio frequency spectrum shared by a plurality of spectrum access systems; managing a move list for the spectrum access system independently of the other spectrum access systems in an absence of exchange of spectrum grant information with the other spectrum access systems; and determining the move list for the spectrum access system from a first moment and a second moment of an aggregate interference distribution such that the spectrum access system provides grants to its secondary users in a dynamic protection area of the spectrum access system. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/340819 |
| CURRENT CPC | Wireless Communication Networks H04W 16/14 (20130101) Original (OR) Class H04W 72/082 (20130101) H04W 72/0453 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210379172 | Salem et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aliasger K. Salem (Coralville, Iowa); Emad I. Wafa (Iowa City, Iowa); Sean M. Geary (Iowa City, Iowa); Ned B. Bowden (Iowa City, Iowa); Jennifer H. Wilson-Welder (Boone, Iowa); David P. Alt (Nevada, Iowa) |
| ABSTRACT | A composition comprising particles formed of poly(diamidosulfide) and one or more leptospiral antigens, and methods of making and using the composition, are provided. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/119384 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1641 (20130101) A61K 39/0225 (20130101) Original (OR) Class A61K 2039/6093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210380965 | Wei et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qingshan Wei (Cary, North Carolina); Jean Beagle Ristaino (Cary, North Carolina); Rajesh Paul (Raleigh, North Carolina); Zhen Gu (Los Angeles, California) |
| ABSTRACT | Methods of extracting analytes of interest from biological samples including soft plant tissues (e.g., plant leaves) or animal tissues are described. The methods include contacting the biological samples with a microneedle that absorbs the analyte of interest. Related systems and methods of detecting pathogens or pests or of genotyping the plant or animal from which the biological sample is derived are described. Also described are methods of delivering a substance of interest (e.g., a pesticide) to a plant by contacting a soft plant tissue with a microneedle coated with the substance of interest. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/342327 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1006 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20210378590 | Reed et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | David A. Reed (Baltimore, Maryland); George C. Emmett (Wilmington, Delaware) |
| ABSTRACT | In an example, a method of detecting cyanide exposure of an individual comprises measuring a thiocyanate level of the individual, and comparing the measured thiocyanate level to a preset thiocyanate threshold to determine whether the measured thiocyanate level is above the preset thiocyanate threshold indicating a level of acute cyanide poisoning for which medical treatment is recommended to treat health effects of the exposure. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/246283 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4845 (20130101) Original (OR) Class A61B 5/14551 (20130101) A61B 10/0051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379411 | Daeffler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Michael Daeffler (Salem, Connecticut); Michael Plumley (New London, Connecticut); Ronald Adrezin (East Lyme, Connecticut) |
| ABSTRACT | In an example, a respirator includes a respirator body having a distal portion and a proximal portion, the distal portion including a filter housing wall and an open distal end. The proximal portion includes a facial interface which is compliant and deformable from an undeformed state to a deformed state to conform to a facial contour of an individual. One or more filter frames are inserted into the distal portion and supported by the filter housing wall to separate filter media on opposite sides of at least one of the one or more filter frames. A filter cover is releasably attached to the open distal end to enclose the one or more filter frames and filter media, forming a filter housing. The one or more filter frames are removable from the distal portion and replaced into the distal portion to allow replacement of the filter media. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/096561 |
| CURRENT CPC | Devices, Apparatus or Methods for Life-saving A62B 7/10 (20130101) Original (OR) Class A62B 18/025 (20130101) A62B 18/084 (20130101) A62B 23/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210378532 | MATTHEWS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cardiac Motion, LLC (Sacramento, California); The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis MATTHEWS (Meadow Vista, California); Xiaomeng GAO (Dublin, California); Xiaonan JIANG (Davis, California); Xiaoguang LIU (Davis, California); Jeremy THOMPSON (Grange, Australia); Kylie DUNNING (Prospect, Australia); Kenneth PAWLAK (Reno, Nevada); Chris RYMAN (Crystal Bay, Nevada) |
| ABSTRACT | Described herein are systems, devices, and methods for non-invasive pregnancy testing. The systems, devices, and methods can be used to provide pregnancy status information of a subject by detecting cardiovascular activity of a fetus in the subject. Subjects can include ruminants, ungulates, and humans. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343364 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 29/005 (20130101) Diagnosis; Surgery; Identification A61B 5/05 (20130101) A61B 5/0011 (20130101) A61B 5/02411 (20130101) Original (OR) Class A61B 5/02438 (20130101) A61B 5/02444 (20130101) A61B 5/6831 (20130101) A61B 5/6867 (20130101) A61B 2503/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210379758 | CHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Diligent Robotics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivian Yaw-Wen CHU (Austin, Texas); Shuai LI (Austin, Texas); Forrest GREEN (Austin, Texas); Peter WORSNOP (Austin, Texas); Andrea Lockerd THOMAZ (Austin, Texas) |
| ABSTRACT | Systems, apparatus, and methods are described for robotic learning and execution of skills. A robotic apparatus can include a memory, a processor, sensors, and one or more movable components (e.g., a manipulating element and/or a transport element). The processor can be operatively coupled to the memory, the movable elements, and the sensors, and configured to obtain information of an environment, including one or more objects located within the environment. In some embodiments, the processor can be configured to learn skills through demonstration, exploration, user inputs, etc. In some embodiments, the processor can be configured to execute skills and/or arbitrate between different behaviors and/or actions. In some embodiments, the processor can be configured to learn an environmental constraint. In some embodiments, the processor can be configured to learn using a general model of a skill. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188445 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/163 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Education (ED)
| US 20210378627 | Yarmush et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Martin L. Yarmush (New Brunswick, New Jersey); Alvin Chen (New Brunswick, New Jersey); Max Balter (New Brunswick, New Jersey); Joshua Leipheimer (New Brunswick, New Jersey) |
| ABSTRACT | A device and method for directing a cannula toward a target location under a patient's skin. The device is handheld and the device operations may be automated. The device includes an imaging probe for imaging the target location, a positioning unit for manipulating a cannula towards the target location, and a processor. The processor receives imaging data from the imaging probe, cannula pose data from at least one cannula position sensor, and device pose data from at least one device position sensor. The target location is identified from the imaging data, and a trajectory for manipulating the cannula towards the target location is determined based on the imaging data, the cannula pose data, and the device pose data. The processor may determine that the trajectory becomes misaligned with the target position, and may update to a corrected trajectory based on the imaging data, cannula pose data, and the device pose data. |
| FILED | Wednesday, October 09, 2019 |
| APPL NO | 17/284018 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) A61B 8/12 (20130101) A61B 8/466 (20130101) A61B 8/0841 (20130101) Original (OR) Class A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210380660 | Meza-Romero et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Roberto Meza-Romero (Beaverton, Oregon); Arthur A. Vandenbark (Portland, Oregon); Halina Offner (Portland, Oregon) |
| ABSTRACT | Recombinant polypeptides comprising a modified DRα1 domain are provided. In some embodiments, the polypeptides include the modified DRα1 domain, an antigenic peptide, and optionally a linker sequence. Pharmaceutical compositions comprising the recombinant polypeptides, methods of treating inflammatory disease using said recombinant polypeptides or pharmaceutical compositions, and expression constructs comprising nucleic acids that encode the recombinant polypeptides are also provided. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282455 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0008 (20130101) A61K 2039/6031 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 14/70539 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20210379171 | Tuohy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent K. Tuohy (Broadview Heights, Ohio); Suparna Mazumder (Olmsted Falls, Ohio); Justin M. Johnson (Willoughby Hills, Ohio) |
| ABSTRACT | Provided herein are methods, kits and compositions for the treatment and/or prevention of ovarian cancer through the induction of an immune response against Anti-Mullerian Hormone Receptor, Type II (AMHR2). |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404025 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/138 (20130101) A61K 31/337 (20130101) A61K 31/502 (20130101) A61K 31/555 (20130101) A61K 31/675 (20130101) A61K 31/704 (20130101) A61K 31/4196 (20130101) A61K 31/4745 (20130101) A61K 31/4985 (20130101) A61K 31/7048 (20130101) A61K 31/7064 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 33/244 (20190101) A61K 39/001102 (20180801) Original (OR) Class A61K 45/06 (20130101) A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 20210379089 | SINGH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eastern Virginia Medical School (Norfolk, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Onkar N. SINGH (Fairfax, Virginia); Timothy J. MCCORMICK (Wilmington, Delaware); Vivek AGRAHARI (Leesburg, Virginia); Melissa PEET (McLean, Virginia); Meredith Roberts CLARK (Bethesda, Maryland); Jill SCHWARTZ (Garrett Park, Maryland); Gustavo F. DONCEL (McLean, Virginia) |
| ABSTRACT | A pharmaceutical composition and methods for using the pharmaceutical composition are disclosed. The pharmaceutical composition may include a therapeutically effective amount of one or more antiviral active pharmaceutical ingredients and a pharmaceutically acceptable excipient. The pharmaceutical composition may be a solid dosage form, wherein the solid dosage form provides sustained release of the antiviral active pharmaceutical ingredient when administered as a vaginal or rectal insert. |
| FILED | Wednesday, October 23, 2019 |
| APPL NO | 17/287030 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0031 (20130101) A61K 9/0034 (20130101) A61K 31/47 (20130101) A61K 31/65 (20130101) A61K 31/675 (20130101) Original (OR) Class A61K 31/4164 (20130101) A61K 31/7052 (20130101) A61K 31/7056 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, December 09, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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