FedInvent™ Patent Applications
Application Details for Thursday, December 16, 2021
This page was updated on Friday, December 17, 2021 at 06:43 AM GMT
Department of Health and Human Services (HHS)
| US 20210386056 | Bomsztyk et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karol Bomsztyk (Seattle, Washington); Daniel Mar (Seattle, Washington); Stephen Scheuerman (Seattle, Washington); Greg Darlington (Seattle, Washington) |
| ABSTRACT | The present technology generally relates to a cryogenic tissue sample storage system. Select embodiments of a tissue sample storage system include a tray having a first well configured to receive a first tissue sample therein a second well configured to receive a second tissue sample therein. The tray can include a first well identification feature associated with the first well and a second well identification feature associated with the second well. The storage system can further include a lid hingedly associated with the tray and movable between (a) a first position in which the first and second wells are occluded by the lid, and (b) a second position in which the first and second wells are externally accessible. The first well identification feature can be unique from the second well identification feature. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348504 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0257 (20130101) A01N 1/0263 (20130101) Original (OR) Class Diagnosis; Surgery; Identification A61B 10/0096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386307 | WU et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); NORTH CAROLNA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min WU (Clarksville, Maryland); Chau-Wai WONG (Apex, North Carolina); Mingliang CHEN (College Park, Maryland); Qiang ZHU (College Park, Maryland); Zachary LAZRI (Gaithersburg, Maryland) |
| ABSTRACT | Systems, methods, apparatuses, and computer program products for contact-free heart rate monitoring and/or measurement are provided. One method may include receiving video(s) that include visual frame(s) of individual(s) performing exercises, detecting some exposed skin from the video(s), and performing motion compensation to generate color signals for the exposed skin to precisely align frames of the exposed skin. The method may also include generating the color signals by estimating a skin color for each frame by taking a spatial average over pixels of a cheek of the face(s) for R, G, and B channels, respectively, applying an operation to remove remaining motion traces from the frames such that the heart rate traces dominate, and extracting and/or outputting the heart rate of the individuals using a frequency estimator of the skin color signals. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/458170 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/725 (20130101) A61B 5/02416 (20130101) Original (OR) Class A61B 5/7207 (20130101) A61B 5/7264 (20130101) A61B 2576/02 (20130101) Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 7/20 (20130101) G06T 7/90 (20170101) G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) G06T 2207/20076 (20130101) G06T 2207/20084 (20130101) G06T 2207/30088 (20130101) G06T 2207/30201 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386333 | Papas |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Klearchos K. Papas (Tucson, Arizona) |
| ABSTRACT | Methods, systems, and devices for regulating blood glucose such as implantable encapsulated devices optionally with insulin and/or glucagon secreting cells in combination with glucose sensors and insulin infusion systems. For example, encapsulation devices may be connected to an insulin infusion pump for distribution of insulin. The insulin infusion pump may feature an insulin pouch fluidly connected to an insulin pump (or a syringe) and a glucose sensor separate from the encapsulation device. The system may feature an additional implantable device comprising insulin and glucagon secreting cells. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387595 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/4839 (20130101) A61B 5/14532 (20130101) Original (OR) Class A61B 5/14865 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386359 | Adeli-Mosabbeb et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Ehsan Adeli-Mosabbeb (Stanford, California); Mandy Lu (Stanford, California); Kathleen Poston (Stanford, California); Juan Carlos Niebles (Stanford, California) |
| ABSTRACT | Many embodiments of the invention include systems and methods for evaluating motion from a video, the method includes identifying a target individual in a set of one or more frames in a video, analyzing the set of frames to determine a set of pose parameters, generating a 3D body mesh based on the pose parameters, identifying joint positions for the target individual in the set of frames based on the generated 3D body mesh, predicting a motion evaluation score based on the identified join positions, providing an output based on the motion evaluation score. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/324979 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1101 (20130101) A61B 5/1121 (20130101) A61B 5/1124 (20130101) A61B 5/1128 (20130101) A61B 5/4082 (20130101) Original (OR) Class A61B 5/7275 (20130101) Image Data Processing or Generation, in General G06T 7/20 (20130101) G06T 17/20 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30004 (20130101) G06T 2210/12 (20130101) G06T 2210/41 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386365 | Woolf et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children`s Medical Center Corporation (Boston, Massachusetts); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clifford J. Woolf (Newton, Massachusetts); Alban A. Latremoliere (Baltimore, Maryland); Thomas E. Scammell (Wellesley, Massachusetts); Chloe M. Alexandre (Baltimore, Maryland) |
| ABSTRACT | This disclosure is related to methods of objectively detecting and measuring neuropathic pain in a subject. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 17/251755 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/374 (20210101) A61B 5/397 (20210101) A61B 5/4809 (20130101) Original (OR) Class A61B 5/4812 (20130101) A61B 5/4824 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/195 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386393 | Li |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Ke Li (Middleton, Wisconsin) |
| ABSTRACT | A system and method for generating a parametric map of a subject's brain includes receiving non-contrast computed tomography (NCCT) imaging data and receiving computed tomography perfusion (CTP) data. The method further includes creating a baseline image by utilizing the NCCT data and generating a parametric map using the CTP data and the baseline image. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 16/901537 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/501 (20130101) A61B 6/507 (20130101) A61B 6/4452 (20130101) A61B 6/5241 (20130101) Original (OR) Class A61B 6/5258 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 11/005 (20130101) G06T 2207/30016 (20130101) G06T 2207/30104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386410 | Chak et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amitabh Chak (Cleveland, Ohio); Sanford Markowitz (Cleveland, Ohio); Dennis Siedlak (Cleveland, Ohio); Joseph Willis (Cleveland, Ohio); Lishan Aklog (Purchase, New York); Michael Boutillette (San Francisco, California); Richard Yazbeck (Norwell, Massachusetts) |
| ABSTRACT | A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state. |
| FILED | Tuesday, June 16, 2020 |
| APPL NO | 16/902579 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0283 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/1025 (20130101) A61M 25/1038 (20130101) A61M 25/10182 (20131105) A61M 2025/1086 (20130101) A61M 2025/1088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386661 | Popov et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexey Popov (Waltham, Massachusetts); Elizabeth M. Enlow (Waltham, Massachusetts); Hongming Chen (Belmont, Massachusetts); James Bourassa (Somerville, Massachusetts) |
| ABSTRACT | Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170701 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) Original (OR) Class A61K 9/5031 (20130101) A61K 9/5123 (20130101) A61K 9/5138 (20130101) A61K 9/5146 (20130101) A61K 31/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386663 | TIZABI et al. |
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| FUNDED BY |
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| APPLICANT(S) | HOWARD UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | HOWARD UNIVERSITY (Washington, District of Columbia) |
| INVENTOR(S) | Yousef TIZABI (Silver Spring, Maryland); Robert L. COPELAND (Washington, District of Columbia) |
| ABSTRACT | A method for treating or mitigating Parkinson's disease (PD) symptoms or progression, including administering an effective amount of nicotine to a subject in need thereof, via inhalation using a nicotine inhaler or via nasal spray using a nicotine nasal spray. Significant dose-dependent improvement of all symptoms by nicotine inhaler or nicotine nasal spray is expected. A novel treatment in PD is thus provided. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 16/897780 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0075 (20130101) Original (OR) Class A61K 31/465 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386680 | CUI et al. |
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| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
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| INVENTOR(S) | Zhengrong CUI (Austin, Texas); Abdulaziz ALDAYEL (Austin, Texas) |
| ABSTRACT | Disclosed herein are nanoparticles for therapeutic and diagnostic use. The nanoparticles are designed to selectively accumulate in a tissue or organ of interest, and then release one or more therapeutically active or diagnostic agents. The nanoparticles include self-crosslinked therapeutic agents and therapeutic agents dispersed in a matrix. |
| FILED | Friday, December 06, 2019 |
| APPL NO | 17/311159 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) Original (OR) Class A61K 9/5192 (20130101) A61K 38/38 (20130101) Peptides C07K 16/241 (20130101) C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386707 | ROGELJ et al. |
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| APPLICANT(S) | New Mexico Tech University Research Park Corporation (Socorro, New Mexico) |
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| INVENTOR(S) | Snezna ROGELJ (Socorro, New Mexico); Danielle Nicole Turner (Socorro, New Mexico); Ivy Hurwitz (Socorro, New Mexico); Alexander Aksenov (Socorro, New Mexico) |
| ABSTRACT | The present disclosure describes a method of treating an infection, including a parasitic infection, using compounds of the invention. The compounds of the invention can selectively eradicate intracellular mammalian and human parasites. |
| FILED | Tuesday, October 29, 2019 |
| APPL NO | 17/286599 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/404 (20130101) A61K 31/405 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386709 | BAKER et al. |
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| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
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| INVENTOR(S) | JEREMY D. BAKER (Seattle, Washington); Rikki L. Uhrich (Seattle, Washington); Timothy J. Stovas (Seattle, Washington); Aleen D. Saxton (Seattle, Washington); Brian C. Kraemer (Seattle, Washington) |
| ABSTRACT | Described herein are compositions and methods for treating Alzheimer's disease, a tauopathy disorder or dementia. The compositions include mammalian suppressor of taupathy 2 (MSUT2) inhibitors. The methods include steps for identifying candidate compositions capable of inhibiting RNA binding proteins to poly(A) RNA and detecting RNA polyadenylation of poly(A) RNA. The methods include reducing accumulation of phosphorylated and aggregated human tau. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319500 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/40 (20130101) A61K 31/41 (20130101) Original (OR) Class A61K 31/55 (20130101) A61K 31/192 (20130101) A61K 31/381 (20130101) A61K 31/445 (20130101) A61K 31/497 (20130101) A61K 31/4709 (20130101) A61K 31/4748 (20130101) A61K 31/4965 (20130101) A61K 31/4985 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386740 | Dietz et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
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| INVENTOR(S) | Harry C. Dietz (Towson, Maryland); Caitlin J. Bowen (Baltimore, Maryland); Juan Francisco Calderon Giadrosic (Santiago, Chile) |
| ABSTRACT | The present invention relates to compositions and methods for treating vascular Ehlers Danlos Syndrome and associated connective tissue disorders. |
| FILED | Wednesday, October 16, 2019 |
| APPL NO | 17/286414 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/69 (20130101) A61K 31/353 (20130101) A61K 31/407 (20130101) A61K 31/436 (20130101) A61K 31/502 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/537 (20130101) A61K 31/4184 (20130101) A61K 31/4523 (20130101) A61K 31/4545 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386743 | Kass et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Kass (Columbia, Maryland); Dong Ik Lee (Baltimore, Maryland); Sumita Mishra (Baltimore, Maryland) |
| ABSTRACT | Studies in female mice lacking ovaries (and thus estrogen), and placed on a high fat diet (60% fat) to induce severe obesity, and then stimulated with a low level of high pressure stress on the heart to induce mild hypertrophy and activate natriuretic peptide signaling. Unlike females on the same diet and heart stress but with their ovaries, those without ovaries demonstrated marked weight loss from phosphodiesterase E-9 (PDE9) inhibition, in combination with improvement in their metabolic signature (reduced fasting glucose, cholesterol, and triglycerides), without any change in food intake, nor change in activity. Thus, in one aspect, the invention provides methods for decreasing body fat and increasing lean muscle mass in estrogen deficient obese female subjects comprising administering to the subjects, at least one PDE9 inhibitor. |
| FILED | Tuesday, October 08, 2019 |
| APPL NO | 17/283217 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386750 | Karnitz et al. |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Larry M. Karnitz (Rochester, Minnesota); Arun Kanakkanthara (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials involved in treating mammals having cancer. For example, a mammal having a breast cancer 1 (BRCA1)-deficient cancer and/or a nicotinamide N-methyltransferase (NNMT) overexpressing cancer can be treated by administering one or more agents that can inhibit mitochondrial metabolism (e.g., one or more oxidative phosphorylation (OXPHOS) inhibitors and/or one or more inhibitors of a mitochondrial polypeptide) and/or one or more agents that can inhibit glucose transport (e.g., one or more inhibitors of a glucose transporter polypeptide such as glucose transporter 1 (GLUT1)) to the mammal. In some cases, one or more OXPHOS inhibitors can be administered to a mammal having a BRCA1-deficient cancer and/or a NNMT overexpressing cancer in combination with one or more poly(ADP-ribose) polymerase (PARP) inhibitors and/or one or more platinum compounds. |
| FILED | Thursday, October 24, 2019 |
| APPL NO | 17/285001 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) Original (OR) Class A61K 31/65 (20130101) A61K 31/235 (20130101) A61K 31/506 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386752 | Shanmugam et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Malathy Shanmugam (Atlanta, Georgia); Aditi Sharma (Atlanta, Georgia) |
| ABSTRACT | In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an electron transport chain complex I inhibitor and/or a complex II succinate ubiquinone reductase (SQR) inhibitor in combination with another anticancer agent such as a BCL-2 antagonist or proteasome inhibitor. In certain embodiments, the cancer is a hematological cancer such as multiple myeloma, chronic lymphocytic leukemia, or acute myeloid leukemia. In certain embodiments, the treatment is under low glucose or fasting conditions. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348487 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/573 (20130101) A61K 31/635 (20130101) A61K 31/4965 (20130101) A61K 31/5377 (20130101) A61K 31/5395 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386754 | CSÁNYI |
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| FUNDED BY |
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| APPLICANT(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia) |
| ASSIGNEE(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia) |
| INVENTOR(S) | Gábor CSÁNYI (Martinez, Georgia) |
| ABSTRACT | One embodiment provides a method for treating atherosclerotic vascular disease in a subject in need thereof by administering to the subject an effective amount of a pharmaceutical composition comprising one or more inhibitors of macropinocytosis to inhibit or reduce receptor-independent LDL macropinocytosis in the subject. In one embodiment, the one or more inhibitors of macrophage macropinocytosis is imipramine or a derivative thereof or any additional macropinocytosis inhibitors independent of their effects on NHE1 activity. In some embodiments the macropinocytosis is macrophage macropinocytosis. A representative atherosclerotic vascular disease is atherosclerosis. |
| FILED | Wednesday, March 03, 2021 |
| APPL NO | 17/191398 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386782 | Clark |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rachael A. Clark (Belmont, Massachusetts) |
| ABSTRACT | Compositions comprising memory T cell Targeting Constructs comprising an anti-T cell antibody or antigen-binding portion thereof linked to a near-infrared photoactivated cytotoxin, e.g., a photoactive adduct of an infrared dye, and methods of use thereof for reducing numbers of pathogenic T cells selectively in peripheral tissues e.g., for treating inflammatory and autoimmune diseases. |
| FILED | Friday, October 18, 2019 |
| APPL NO | 17/286194 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 41/0071 (20130101) A61K 47/6849 (20170801) Peptides C07K 16/2809 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386791 | TSENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | TissueTech, Inc. (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scheffer TSENG (Pinecrest, Florida); Frank E. YOUNG (Miami, Florida); Ying-Tieng ZHU (Miami, Florida); Szu Yu CHEN (Miami, Florida) |
| ABSTRACT | Disclosed herein are methods of cellular reprogramming, comprising contacting a cell with HC-HA/PTX3 for a time sufficient for cellular reprogramming of the phenotype of the cell to a different phenotype. |
| FILED | Wednesday, November 06, 2019 |
| APPL NO | 17/291070 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 35/30 (20130101) A61K 35/33 (20130101) A61K 35/34 (20130101) A61K 35/50 (20130101) A61K 35/51 (20130101) Original (OR) Class A61K 35/545 (20130101) A61K 47/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386799 | SURANA et al. |
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| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neeraj K. SURANA (Durham, North Carolina); Dennis KASPER (Cambridge, Massachusetts) |
| ABSTRACT | In certain aspects, described herein are methods, bacteria, and compositions for the treatment of bacterial infections. Specifically, bacteria that can upregulate antimicrobial peptides, e.g., Reg3, within a subject have been identified and methods of using such bacteria to treat infections is described. |
| FILED | Wednesday, September 25, 2019 |
| APPL NO | 17/279386 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/135 (20160801) Indexing Scheme Relating to Lactic or Propionic Acid Bacteria Used in Foodstuffs or Food Preparation A23Y 2220/71 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/747 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386828 | Shalapour et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shabnam Shalapour (La Jolla, California); Michael Karin (La Jolla, California) |
| ABSTRACT | Provided herein are methods of inducing expression of major histocompatibility complex (MHC) molecules on a cancer cell surface by inducing expression of one or more genes associated with MHC. Also disclosed are methods of screening for agents useful in treating cancer and methods of treating such cancers. |
| FILED | Thursday, December 19, 2019 |
| APPL NO | 17/416403 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 33/243 (20190101) A61K 38/217 (20130101) Original (OR) Class A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386829 | Wallrapp et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Antonia Wallrapp (Boston, Massachusetts); Patrick R. Burkett (Boston, Massachusetts); Vijay K. Kuchroo (Boston, Massachusetts); Aviv Regev (Cambridge, Massachusetts); Samantha J. Riesenfeld (Cambridge, Massachusetts); Heping Xu (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides novel compositions and methods based on the discovery of the mechanisms and gene expression programs associated with homeostatic ILC2s and proinflammatory ILC2s that drive tissue inflammation. Molecular cues were identified that modulate ILC responses to alarmins using single-cell RNA-sequencing (scRNA-seq) profiles of lung-resident ILCs at steady state and after in vivo stimulation. The neuropeptide CGRP and the CGRP receptor were identified as expressed on ILC2s. Treatment with CGRP reduces allergic lung inflammation and reduces the proliferation and expansion of ILC2 cells. The results demonstrate that CGRP signaling strongly modulates ILC2 responses and highlights the importance of neuro-immune crosstalk in allergic inflammatory responses at mucosal surfaces. |
| FILED | Monday, May 06, 2019 |
| APPL NO | 17/052873 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/225 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386831 | JOSEPH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THERMALIN INC. (WABAN, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey I. JOSEPH (Penn Valley, Pennsylvania); Richard William BERENSON (Waban, Massachusetts); Bruce FRANK (Indianapolis, Indiana); Michael A. WEISS (Moreland Hills, Ohio); Thomas HATTIER (Cleveland Heights, Ohio); Gregory DUBÉ (Littleton, Massachusetts); Zhiqiang CHEN (Cleveland, Ohio) |
| ABSTRACT | The present invention provides rapid-acting insulin and insulin analogue formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogues, as well as other active agents. Methods of using the insulin and insulin analogue formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335141 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0021 (20130101) A61K 36/05 (20130101) A61K 36/23 (20130101) A61K 38/28 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/12 (20130101) A61K 47/20 (20130101) A61K 47/36 (20130101) A61K 47/183 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) A61M 5/1723 (20130101) A61M 25/02 (20130101) A61M 37/0092 (20130101) A61M 2025/0253 (20130101) A61M 2037/0007 (20130101) A61M 2205/35 (20130101) A61M 2205/50 (20130101) A61M 2205/055 (20130101) A61M 2205/502 (20130101) A61M 2230/201 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/327 (20130101) A61N 1/0448 (20130101) A61N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386837 | Batlle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Batlle (Evanston, Illinois); Jan Wysocki (Evanston, Illinois); Robert Lavker (Evanston, Illinois) |
| ABSTRACT | Disclosed herein are compositions and methods useful for treating diseases and conditions of the cornea in a subject in need thereof, comprising administering a therapeutically effective amount of an angiotensin converting enzyme 2 (ACE2) and/or variants of ACE2 to the subject. The disclosed variants of ACE2 may include fragments of ACE2 having ACE2 biological activity for converting AngII (1-8) to Ang (1-7). |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/303032 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/4813 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386838 | GEORGIOU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | George GEORGIOU (Austin, Texas); Everett STONE (Austin, Texas); Wei-Cheng LU (Austin, Texas) |
| ABSTRACT | Methods and compositions relating to the engineering of an improved protein with homocyst(e)inase enzyme activity are described. For example, there are disclosed modified cystathionine-γ-lyase (CGL) enzymes comprising one or more amino acid substitutions and capable of degrading homocyst(e)ine. Furthermore, provided are compositions and methods for the treatment of homocystinuria or hyperhomocysteinemia with homocyst(e)ine depletion using the disclosed enzymes or nucleic acids. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/330106 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/19 (20130101) A61K 31/4415 (20130101) A61K 38/51 (20130101) Original (OR) Class A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) C12N 9/96 (20130101) C12N 15/70 (20130101) C12N 15/80 (20130101) C12N 15/861 (20130101) C12N 15/867 (20130101) C12N 15/869 (20130101) Enzymes C12Y 404/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386848 | Ficht et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. Ficht (College Station, Texas); Allison Ficht (College Station, Texas); Renee Tsolis (Davis, California); Leslie Garry Adams (College Station, Texas); Angela M. Arenas-Gamboa (College Station, Texas) |
| ABSTRACT | Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to vaccines. In additional embodiments, the invention relates to formulations capable of releasing said vaccines at a controlled rate of release in vivo. In further embodiments, the invention relates to modified strains of the bacteria Brucella melitensis and Brucella abortus. In still further embodiments, the invention relates to compositions that do not induce clinical symptoms or splenomegaly in a subject receiving said compositions. |
| FILED | Monday, January 18, 2021 |
| APPL NO | 17/151488 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/098 (20130101) Original (OR) Class A61K 2039/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386851 | YAMAMOTO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (GAINESVILLE, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JANET K. YAMAMOTO (GAINESVILLE, Florida) |
| ABSTRACT | The subject invention pertains to materials and methods for detecting, preventing and treating retroviral infections in humans and other animals susceptible to infection by retrovirus. It has been discovered that FIV can be transmitted from cats to humans and that the FIV can infect human cells in vivo and that antibodies generated by the infected person cross-react with HIV antigens. Thus, the methods and compositions of the subject invention can be used to detect, prevent and treat FIV infection in humans and other non-feline animals that are susceptible to FIV infection. The methods and compositions of the invention can also be used to prevent and treat infection by HIV in humans. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/444242 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/21 (20130101) Original (OR) Class A61K 39/295 (20130101) Peptides C07K 14/161 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/702 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386860 | Herrmann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California) |
| ASSIGNEE(S) | City of Hope (Duarte, California) |
| INVENTOR(S) | Andreas Herrmann (Del Mar, California); Hua Yu (Glendora, California) |
| ABSTRACT | Provided herein are, inter alia, nucleic acid conjugates including a non-cell penetrating ribonucleic acid compound attached at its 3′ end to a phosphorothioate polymer. Attachment of the phosphorothioate polymer to the non-cell penetrating ribonucleic acid conveys stability to and allows for efficient intracellular delivery of the non-cell penetrating ribonucleic acid. The nucleic acid conjugates provided herein including embodiments thereof are useful, inter alia, for the treatment of cancer, inflammatory disease, and pain. |
| FILED | Tuesday, March 30, 2021 |
| APPL NO | 17/217989 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/548 (20170801) A61K 47/549 (20170801) Original (OR) Class A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386874 | Sharma |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Vijay Sharma (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides for imaging agents and methods of making and using the same. The imaging agent comprises a luminol component comprising a luminol moiety or functional analogue thereof; a chelator; a linker group bonding or complexing the luminol component to the chelator; and a radiolabel component bound to the chelator. The imaging agent described herein is capable of monitoring, targeting, or imaging oxidative stress, reactive oxygen species (ROS), superoxide generation, or hydrogen peroxide generation, mediating pathophysiology of different disease states. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344739 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0459 (20130101) Original (OR) Class A61K 51/0482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386875 | Achilefu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Achilefu (St. Louis, Missouri); Kvar Black (St. Louis, Missouri) |
| ABSTRACT | The present invention encompasses compositions comprising two spectrally distinct radionuclides separated by a site susceptible to cleavage. Compositions of the invention may be used to detect enzyme activity and/or image diseases associated with said enzyme activity. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319780 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/088 (20130101) Original (OR) Class A61K 51/1251 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386879 | Krafft et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Grant A. Krafft (Glenview, Illinois); William L. Klein (Winetka, Illinois); Brett A. Chromy (Danville, California); Lei Chang (Westmont, Illinois); Mary P. Lambert (San Antonio, Texas); Kirsten L. Viola (Chicago, Illinois) |
| ABSTRACT | A method for detecting soluble oligomeric amyloid β in a subject is provided. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/411400 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/1018 (20130101) Original (OR) Class Peptides C07K 16/18 (20130101) C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/76 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2333/4709 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386907 | HARTGERINK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Jeffrey HARTGERINK (Houston, Texas); David LEACH (Houston, Texas); Tania LOPEZ-SILVA (Houston, Texas) |
| ABSTRACT | Provided herein are peptide-based hydrogels, or neutral multidomain peptide hydrogel (NMDP), as well as uses thereof. The uses include encapsulating cells to induce quiescence for long-term storage and administering to a subject to induce collagen deposition and macrophage infiltration. The disclosed hydrogel is useful for the preservation of stem cells, including maintaining their quiescence and differentiation potential. |
| FILED | Wednesday, October 16, 2019 |
| APPL NO | 17/285767 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0231 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/22 (20130101) Original (OR) Class A61L 27/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387957 | Andersen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of British Columbia (Vancouver, Canada); Provincial Health Services Authority (Vancouver, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond J. Andersen (Vancouver, Canada); Marianne Dorothy Sadar (West Vancouver, Canada); Kunzhong Jian (Surrey, Canada); Nasrin R. Mawji (Burnaby, Canada); Jun Wang (Surrey, Canada); Carmen Adriana Banuelos (Richmond, Canada); Yu-Chi Yang (Burnaby, Canada) |
| ABSTRACT | Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404589 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/09 (20130101) A61K 31/10 (20130101) A61K 31/145 (20130101) A61K 31/4164 (20130101) A61K 31/5375 (20130101) A61K 45/06 (20130101) Acyclic or Carbocyclic Compounds C07C 43/23 (20130101) C07C 69/28 (20130101) C07C 233/18 (20130101) C07C 311/04 (20130101) C07C 311/51 (20130101) C07C 317/18 (20130101) C07C 317/22 (20130101) C07C 317/28 (20130101) Heterocyclic Compounds C07D 233/60 (20130101) C07D 295/088 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387986 | Sheppard et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean Sheppard (Oakland, California); Aparna Sundaram (San Francisco, California); William F. DeGrado (San Francisco, California); Hyunil Jo (Lafayette, California) |
| ABSTRACT | Disclosed herein, inter alia, are inhibitors of integrin alpha 2 beta 1 and methods of using the same. |
| FILED | Wednesday, March 13, 2019 |
| APPL NO | 16/979096 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 275/24 (20130101) C07C 275/26 (20130101) C07C 2602/08 (20170501) C07C 2602/10 (20170501) C07C 2602/42 (20170501) C07C 2603/74 (20170501) Heterocyclic Compounds C07D 207/48 (20130101) C07D 213/81 (20130101) C07D 277/06 (20130101) C07D 471/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388012 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (Memphis, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard E. LEE (Cordova, Tennessee); Jiuyu LIU (Collierville, Tennessee) |
| ABSTRACT | In one aspect, the disclosure relates to substituted spectinomycin analogs, including substituted aminomethyl spectinomycin analogs and substituted spectinamide analogs, with increased tolerability and safety, including improved tolerability to parenteral administration. The present disclosure further pertains to methods of making disclosed compounds, pharmaceutical compositions comprising the disclosed compounds, and methods of treating microbial infections using the disclosed compounds, including methods of treating antibiotic resistant infections and tuberculosis. This abstract is intended as a scanning tool for pur-poses of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Monday, November 05, 2018 |
| APPL NO | 17/288493 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 493/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6561 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388031 | Kumar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Dr. Vivek A. Kumar (Newark, New Jersey) |
| ABSTRACT | Disclosed is a new strategy, composition, and method for a self-assembling peptides (SAP) that will self-assemble atop COVID-19 for immune destruction and act as a functional COVID-19 opsonin. The designed self-assembling peptides bind and assemble atop SARS-CoV-2—providing a new mechanism of infection abrogation. One benefit is avoidance of side effects that other formulations or repurposed drugs contain. Other feature of this technology include: (a) (SAP) are composed of L-amino acids that are highly biocompatible sub-Q, IM and IV (no adverse reaction for 10% blood volume replacement with 1 w % peptide in mice or rats); (b) Highly targeted approach that binds to viral particles preventing side effects; (c) SAP are intrinsically biodegradable and endocytosed; (d) SAP bound COVID-19 may promote engulfment, clearance, and antigen presentation (for immunity development); and (e) targeting the spike protein with SAP may allow treatment of other coronaviruses. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/348994 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/735 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388032 | LANGEDIJK et al. |
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| FUNDED BY |
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| APPLICANT(S) | Janssen Pharmaceuticals, Inc. (Titusville, New Jersey); Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Johannes Petrus Maria LANGEDIJK (Amsterdam, Netherlands); Lucy RUTTEN (Rijnsburg, Netherlands); Mark Johannes Gerardus BAKKERS (Haarsteeg, Netherlands); Rinke BOS (Oegstgeest, Netherlands); Frank WEGMANN (Leiden, Netherlands); David Adrianus Thedorus Maria ZUIJDGEEST (Den Haag, Netherlands); Dan H. BAROUCH (Newton, Massachusetts); An VANDEBOSCH (Herentals, Belgium); Mathieu Claude Michel le GARS (Antwerp, Belgium); Jerald C. SADOFF (Washington, District of Columbia) |
| ABSTRACT | The invention relates to immunogenic compositions and vaccines containing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; also referred to as SARS-CoV-2)) protein or a polynucleotide encoding a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) protein and uses thereof. The invention also provides methods of treating and/or preventing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) infection by administering an immunogenic composition or vaccine to a subject (e.g., a human). The invention also provides methods of detecting and/or monitoring a protective anti-coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) antibody response (e.g., anti-coronavirus antibody response, e.g., anti-2019-nCoV antibody response, e.g., anti-Spike antibody response, e.g., anti-Spike neutralizing antibody response). The present invention relates to isolated nucleic and/or recombinant nucleic acid encoding a coronavirus S protein, in particular a SARS-CoV-2 S protein, and to the coronavirus S proteins, as well as to the use of the nucleic acids and/or proteins thereof in vaccines. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387105 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388034 | Nabel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Gary J. Nabel (Chestnut Hill, Massachusetts); Srinivas Rao (Columbia, Maryland); Wataru Akahata (Kensington, Maryland) |
| ABSTRACT | The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the modified VLPs. The invention also features methods for enhancing production of modified VLPs for use in the prevention or treatment of alphavirus and flavivirus-mediated diseases. The invention also provides methods for delivering agents to a cell using the modified VLPs. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/410182 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/53 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388040 | Kadoch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cigall Kadoch (Tiburon, California); Brittany C. Michel (Brookline, Massachusetts); Andrew D'Avino (Boston, Massachusetts) |
| ABSTRACT | The present invention provides compositions and methods for treating cancers with canonical BAF (cBAF) complex perturbations (e.g. synovial sarcoma or malignant rhabdoid tumor) using an agent that inhibits the formation, activity, and/or stability of the ncBAF complex. |
| FILED | Tuesday, October 15, 2019 |
| APPL NO | 17/283797 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) Peptides C07K 14/47 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388055 | Spencer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | EMORY UNIVERSITY (Atlanta, Georgia); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| INVENTOR(S) | H. Trent Spencer (Marietta, Georgia); Christopher B. Doering (Atlanta, Georgia); Philip M. Zakas (Atlanta, Georgia); Eric Gaucher (Atlanta, Georgia) |
| ABSTRACT | This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 17/355656 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/755 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388066 | WESTENDORF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Kathryn WESTENDORF (Vancouver, Canada); Stefanie ZENTELIS (Vancouver, Canada); Krithika MUTHURAMAN (Toronto, Canada); Kevin JEPSON (Vancouver, Canada); Ester FALCONER (Vancouver, Canada); John MASCOLA (Bethesda, Maryland); Barney GRAHAM (Bethesda, Maryland); Kizzmekia CORBETT (Bethesda, Maryland); Julie LEDGERWOOD (Bethesda, Maryland); Lingshu WANG (Bethesda, Maryland); Olubukola ABIONA (Bethesda, Maryland); Wei SHI (Bethesda, Maryland); Wing-pui KONG (Bethesda, Maryland); Yi ZHANG (Bethesda, Maryland); Bryan Edward JONES (San Diego, California); Denisa FOSTER (San Diego, California); Julian DAVIES (La Jolla, California); Qing CHAI (San Diego, California); Christopher Carl FRYE (Bargersville, Indiana); Ganapathy GOPALRATHNAM (Fishers, Indiana); Jörg HENDLE (San Diego, California); John Michael SAUDER (Carlsbad, California); Jeffrey Streetman BOYLES (Indianapolis, Indiana); Anna PUSTILNIK (San Diego, California) |
| ABSTRACT | Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354434 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 47/6801 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388069 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Herbert Y. Lin (Watertown, Massachusetts); Jodie Babitt (Newton, Massachusetts) |
| ABSTRACT | Modulation of iron homeostasis by regulating BMP-6 activity is provided. Methods of using BMP-6 and BMP-6 protein-specific reagents, such as antibodies, for altering serum iron levels in humans are provided. Such antibodies are useful in pharmaceutical compositions for the prevention and treatment of hemochromatosis and anemia of inflammation. |
| FILED | Tuesday, January 19, 2021 |
| APPL NO | 17/152531 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388078 | Stanley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine, Inc (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard E. Stanley (New York, New York); Violeta Chitu (Scarsdale, New York) |
| ABSTRACT | Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is caused by dominant inactivating mutations in the colony stimulating factor receptor 1 (CSF1R) kinase domain. GM-CSF haploinsufficiency corrects olfactory, cognitive and emotional functions lost in Csf1r+/− mice. This correlates with the correction of microgliosis and microglial functions resulting in improvement of myelination and rescue of neurogenesis. However, GM-CSF haploinsufficiency fails to correct the motor deficits of Csf1r+/− mice and cerebellar microgliosis. The present invention discloses methods and compositions using GM-CSF as a suitable therapeutic target to inhibit in amelioration of the cognitive impairments in ALSP and other in conditions involving inflammatory activation of microglia and macrophages, such as AD, ALS, multiple sclerosis, and hippocampal inflammation following radiation therapy. Treatment with GM-CSF inhibitors is beneficial in ALSP, as adult neurogenesis is important for memory, olfaction and prevention of anxiety/depression and early initiation of such treatment in carriers of CSF1R mutations may increase effectiveness. Balancing the actions of CSF-1R and GM-CSF signaling are necessary to preserve olfaction, cognition and emotional balance in aged mice. This balance is likely altered in many neurodegenerative diseases in which activated microglia contribute to the pathology. |
| FILED | Sunday, October 13, 2019 |
| APPL NO | 17/284599 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/243 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388080 | Rohrer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of The University of Colorado, A Body Corporate (Denver, Colorado); MUSC Foundation For Research Development (Charleston, South Carolina); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baerbel M. Rohrer (Charleston, South Carolina); V. Michael Holers (Denver, Colorado); Stephen Tomlinson (Charleston, South Carolina); Joshua M. Thurman (Greenwood Village, Colorado); Carl Atkinson (Mount Pleasant, South Carolina); Liudmila Kulik (Aurora, Colorado) |
| ABSTRACT | The present invention provides targeted delivery methods and constructs for treating inflammatory diseases and/or detecting in vivo tissue injuries in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The invention also provides methods of inhibiting complement-driven inflammation in the eye in an individual, comprising administering to the individual an antibody or a fragment thereor or compositions thereof, wherein the antibody or fragment thereof specifically binds to Annexin IV or phospholipid. Also provided are related methods of treating a complement-associated ocular disease or an ocular disease involving oxidative damage. Additionally, the invention provides methods of detecting complement-mediated injury in an eye tissue of an individual, comprising administering to the individual a construct or compositions thereof, wherein the construct comprises (a) an antibody or fragment thereof that specifically binds to Annexin IV or phospholipid; and (b) a detectable moiety. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228279 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388093 | Miller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey S. Miller (Minneapolis, Minnesota); Martin Felices (Minneapolis, Minnesota); Daniel A. Vallera (Minneapolis, Minnesota); Todd R. Lenvik (Minneapolis, Minnesota) |
| ABSTRACT | Provided are compositions for activating NK cells to stimulate an immune response for treating cancer and other disorders. In one embodiment, the invention provides a compound comprising an NK engaging domain that binds to CD 16; an NK activating domain operably linked to the NK engaging domain; and a targeting domain that selectively binds to a target cell and is operably linked to the NK activating domain and the NK engaging domain, wherein the targeting domain binds to CLEC12A. |
| FILED | Thursday, October 17, 2019 |
| APPL NO | 17/285447 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) C07K 16/283 (20130101) C07K 16/2851 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/24 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388094 | Scadden et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David T. Scadden (Weston, Massachusetts); Rahul Palchaudhuri (Cambridge, Massachusetts); Derrick J. Rossi (Newton, Massachusetts); Agnieszka D. Czechowicz (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein are non-myeloablative antibody-toxin conjugates and compositions that target cell surface markers, such as the CD34, CD45 or CD117 receptors, and related methods of their use to effectively conditioning a subject's tissues (e.g., bone marrow tissue) prior to engraftment or transplant. The compositions and methods disclosed herein may be used to condition a subject's tissues in advance of, for example, hematopoietic stem cell transplant and advantageously such compositions and methods do not cause the toxicities that are commonly associated with traditional conditioning methods. |
| FILED | Tuesday, December 29, 2020 |
| APPL NO | 17/137337 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 38/164 (20130101) A61K 38/168 (20130101) A61K 47/6825 (20170801) A61K 47/6849 (20170801) A61K 47/6898 (20170801) Peptides C07K 4/04 (20130101) C07K 16/289 (20130101) C07K 16/2866 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/50 (20130101) G01N 33/56966 (20130101) G01N 33/57407 (20130101) G01N 33/57434 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388113 | Morgan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Richard A. Morgan (Center Harbor, New Hampshire); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/410129 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 48/00 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70575 (20130101) C07K 14/70578 (20130101) C07K 14/70596 (20130101) C07K 16/32 (20130101) Original (OR) Class C07K 16/2863 (20130101) C07K 16/3053 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388116 | Miller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yury Miller (San Diego, California); Ayelet Gonen (La Jolla, California); Sotirios Tsimikas (Rancho Santa Fe, California); Joseph L. Witztum (San Diego, California) |
| ABSTRACT | Provided herein are new diagnostic biomarkers for cardiovascular disease, antibodies for detecting said diagnostic biomarkers, and immunoassays, imaging agents, and therapeutics based therefrom. |
| FILED | Friday, November 01, 2019 |
| APPL NO | 17/290843 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2217/05 (20130101) A01K 2227/105 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 51/1018 (20130101) Peptides C07K 16/44 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2510/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388119 | Bradley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| INVENTOR(S) | Philip Bradley (Seattle, Washington); Barry L. Stoddard (Seattle, Washington) |
| ABSTRACT | Circular handed alpha-helical repeat proteins are described. The repeat proteins have a number of uses as scaffolds for geometrically precise, arrayed presentation of cell-signaling or immune-related protein and peptide epitopes, as well as numerous other therapeutic, diagnostic, and nanotechnological uses. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/361087 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/08 (20130101) C07K 14/00 (20130101) C07K 14/001 (20130101) C07K 14/44 (20130101) C07K 14/47 (20130101) C07K 14/55 (20130101) C07K 19/00 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388301 | INGBER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald E. INGBER (Boston, Massachusetts); Anthony BAHINSKI (Wilmington, Delaware); Robert CUNNINGHAM (Cohasset, Massachusetts); Josue A. GOSS (Somerville, Massachusetts); Geraldine A. HAMILTON (Cambridge, Massachusetts); Christopher David HINOJOSA (Cambridge, Massachusetts); Daniel LEVNER (Boston, Massachusetts); Kevin Kit PARKER (Waitham, Massachusetts) |
| ABSTRACT | The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/146264 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/02 (20130101) A01N 1/021 (20130101) A01N 1/0247 (20130101) A01N 1/0273 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502715 (20130101) B01L 9/52 (20130101) B01L 2200/146 (20130101) B01L 2200/147 (20130101) B01L 2200/0684 (20130101) B01L 2200/0689 (20130101) B01L 2300/18 (20130101) B01L 2300/044 (20130101) B01L 2300/123 (20130101) B01L 2300/0636 (20130101) B01L 2300/0654 (20130101) B01L 2300/0663 (20130101) B01L 2300/0867 (20130101) B01L 2300/0877 (20130101) B01L 2400/0487 (20130101) B01L 2400/0622 (20130101) B01L 2400/0644 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/42 (20130101) C12M 29/10 (20130101) C12M 35/04 (20130101) C12M 35/08 (20130101) C12M 41/00 (20130101) C12M 41/12 (20130101) C12M 41/46 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) G01N 33/5082 (20130101) G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388321 | Kyba et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael S. Kyba (Minneapolis, Minnesota); Natalya Goloviznina (Minneapolis, Minnesota); Ning Xie (Minneapolis, Minnesota); Abhijit Dandapat (Lexington, Massachusetts) |
| ABSTRACT | The present disclosure provides methods of producing a preparation of fibroadipogenic progenitors (FAPs) from a cell mixture. In certain embodiments, the present disclosure provides a method of producing a preparation of human FAPs from a skeletal muscle biopsy sample for later use. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/346948 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0653 (20130101) C12N 5/0656 (20130101) C12N 5/0658 (20130101) Original (OR) Class C12N 2501/599 (20130101) C12N 2506/13 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 33/56966 (20130101) G01N 2001/302 (20130101) G01N 2333/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388325 | Emery et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Caroline Emery (Kansas City, Missouri); Rajee Antony (Norwood, Massachusetts); Levi A. Garraway (Newton, Massachusetts) |
| ABSTRACT | Nucleic acids and proteins having a mutant C-RAF sequence, and methods of identifying patients having cancer who are likely to benefit from a combination therapy and methods of treatment are provided. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399563 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 207/11001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388348 | Sontheimer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erik Joseph Sontheimer (Auburndale, Massachusetts); Anastasia Khvorova (Westborough, Massachusetts); Jonathan Kenneth Watts (Worcester, Massachusetts); Nadia Amrani (Shrewsbury, Massachusetts); Zexiang Chen (Worcester, Massachusetts); Matthew Hassler (Boston, Massachusetts); Dimas Echeverria Moreno (Worcester, Massachusetts); Julia Frances Alterman (Boston, Massachusetts); Scot Wolfe (Boston, Massachusetts); Ken Yamada (Boston, Massachusetts); Gitali Devi (Boston, Massachusetts); Han Zhang (Boston, Massachusetts) |
| ABSTRACT | Chemically modified crRNAs and tracrRNAs are provided. crRNAs and tracrRNAs with 5′ and/or 3′ conjugated moieties are provided. crRNAs and tracrRNAs with modifications in the repeat region of the crRNA or the anti-repeat region of the tracrRNA are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided. |
| FILED | Wednesday, May 12, 2021 |
| APPL NO | 17/318846 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2310/315 (20130101) C12N 2310/322 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388362 | Roth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore Lee Roth (San Francisco, California); Alexander Marson (San Francisco, California) |
| ABSTRACT | Provided herein are methods and compositions for editing the genome of a cell. In some embodiments, a nucleotide sequence of at least 200 nucleotides in length is inserted into a target region in the genome of a cell. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/326252 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2320/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388389 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sidi Chen (Milford, Connecticut); Xiaoyun Dai (West Haven, Connecticut) |
| ABSTRACT | Disclosed are compositions and methods for cellular genome engineering that permit simple, efficient, and versatile permutations of combinatorial or simultaneous knockout and knock-in genomic modifications. An exemplary method includes modifying the genome of a cell by introducing to the cell a Cpf1 endonuclease and one or more AAV vectors encoding one or more crRNAs that direct the endonuclease to one or more target genes. The AAV vectors further contain one or more HDR templates that provide a sequence that encodes a reporter gene, a chimeric antigen receptor (CAR), or combinations thereof, and sequences homologous to one or more target sites. Also disclosed are pharmaceutical compositions containing genetically modified cells and methods of use thereof in treating a subject having a disease or disorder, such as cancer. The disclosed compositions and methods are especially applicable to development of enhanced chimeric antigen receptor engineered T cell therapy (CAR-T). |
| FILED | Tuesday, October 22, 2019 |
| APPL NO | 17/290641 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2501/70 (20130101) C12N 2501/515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388393 | Zhao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ANN and ROBERT H. LURIE CHILDREN'S HOSPITAL OF CHICAGO (CHICAGO, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Youyang Zhao (Deerfield, Illinois) |
| ABSTRACT | Provided herein is a composition comprising a nanoparticle comprising poly(lactic acid-co-glycolic acid) (PLGA)-b-polyethylene glycol (PEG) (PLGA-PEG) copolymer formulated with polyethylenimine (PEI), and one or more cargo molecules (e.g., a nucleic acid molecule with or without a small molecule compound) associated with the nanoparticle. The nucleic acid molecule may be a plasmid or minicircle DNA expressing a gene or genes, CRISPR/Cas9 components, or an RNA molecule (e.g., small interfering RNA, miRNA, or lncRNA). Also provided are methods for delivering a cargo molecule to a cell in vitro and in vivo using the aforementioned composition. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/284262 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/88 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388394 | Doudna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emmanuelle Charpentier (Berlin, Germany); The Regents of the University of California (Oakland, California); University of Vienna (Vienna, Austria) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Martin Jinek (Berkeley, California); Krzysztof Chylinski (Vienna, Austria); Emmanuelle Charpentier (Berlin, Germany) |
| ABSTRACT | The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348596 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/4684 (20180501) Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/746 (20130101) C12N 15/902 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/13 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Enzymes C12Y 301/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388395 | Doudna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emmanuelle Charpentier (Berlin, Germany); The Regents of the University of California (Oakland, California); University of Vienna (Vienna, Austria) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Martin Jinek (Berkeley, California); Krzysztof Chylinski (Vienna, Austria); Emmanuelle Charpentier (Berlin, Germany) |
| ABSTRACT | The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348619 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/4684 (20180501) Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/746 (20130101) C12N 15/902 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/13 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Enzymes C12Y 301/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210388426 — RATIOMETRIC FLUORESCENCE CODING METHOD FOR MULTIPLEX NUCLEIC ACID AMPLIFICATION ASSAYS
| US 20210388426 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Tza-Huei Jeff WANG (Timonium, Maryland); Ye ZHANG (Baltimore, Maryland) |
| ABSTRACT | Methods for multiplexed detection of a nucleic acid sequence in a sample including the use of a plurality of oligonucleotide target-specific probes (TSPs) configured to bind to a distinct target nucleic acid sequence, where each of the TSPs includes one or more copies of a first fluorescent probe (FP) binding region and one or more copies of a second FP binding region, and where a predetermined ratio of the one or more copies of the first FP binding region to the one or more copies of the second FP binding region is indicative of the distinct target nucleic acid sequence the TSP is configured to bind to. |
| FILED | Friday, December 20, 2019 |
| APPL NO | 17/416399 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502753 (20130101) B01L 3/502784 (20130101) B01L 2300/087 (20130101) B01L 2300/0819 (20130101) B01L 2300/0896 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) Original (OR) Class C12Q 2600/154 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0032 (20130101) G02B 21/0076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388430 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David Yu Zhang (Cambridge, Massachusetts); Peng Yin (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are primers and primer systems having improved specificity and kinetics over existing primers, and methods of use thereof. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/169145 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6832 (20130101) C12Q 1/6848 (20130101) C12Q 1/6853 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388444 | Kwiatkowski, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts) |
| INVENTOR(S) | Thomas J. Kwiatkowski, JR. (Cambridge, Massachusetts); Robert H. Brown, JR. (Needham, Massachusetts) |
| ABSTRACT | The invention provides novel FUS/TLS nucleic acids and proteins that comprise one or more genetic markers (for example, single nucleotide polymorphisms) and methods of use thereof including methods relating to the diagnosis of ALS or other related motor neuron disease by virtue of the presence of the mutant FUS/TLS sequence(s). |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/325279 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6837 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/172 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388447 | Gartner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of The University of California (Oakland, California) |
| INVENTOR(S) | Zev J. Gartner (San Francisco, California); David Patterson (San Francisco, California); Eric D. Chow (San Francisco, California); Robert Weber (San Francisco, California); Christopher McGinnis (San Francisco, California) |
| ABSTRACT | Disclosed are compositions comprising a first lipid-conjugated oligonucleotide comprising a first lipid moiety, a first hybridization region, and a first primer region; a second lipid-conjugated oligonucleotide comprising a second hybridization region and a second lipid moiety, wherein the second hybridization region is the reverse complement of the first hybridization region; and a third oligonucleotide comprising a second primer region, a barcode region, and a capture sequence, wherein the second primer region is the reverse complement of the first primer region; compositions comprising a lipid-conjugated DNA oligonucleotide comprising a lipid moiety, a barcode region, and a capture sequence; and composition comprising a first lipid-conjugated DNA oligonucleotide comprising a lipid moiety and a first primer region; and a second DNA oligonucleotide comprising a second primer region, a barcode region, and a capture sequence, wherein the second primer region is the reverse complement of the first primer region. Also disclosed are membranes and cells comprising such compositions and uses of such compositions. |
| FILED | Monday, July 08, 2019 |
| APPL NO | 17/258420 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388454 | PAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, Baltimore (Baltimore, Maryland); University of Maryland, Baltimore County (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DIPANJAN PAN (ELLICOTT CITY, Maryland); PARIKSHIT MOITRA (BALTIMORE, Maryland); MAHA MOHAMMAD SHEHADEH ALAFEEF (BALTIMORE, Maryland); KETAN DIGHE (ELLICOTT CITY, Maryland) |
| ABSTRACT | The present disclosure relates to a nanotechnology-based molecular sensing system, compositions, and methods that can be adapted to accurately detect a target gene in clinical samples, using anti-sense oligonucleotide capped plasmonic nanoparticles for selective detection of biological pathogens. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/325839 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 1/707 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389222 | Savoy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nanohmics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Nanohmics, Inc. (Austin, Texas) |
| INVENTOR(S) | Steve M. Savoy (Austin, Texas); Elzbieta A. Ledwosinska (Austin, Texas); Jeremy J. John (Austin, Texas); Kyle W. Hoover (Austin, Texas); Daniel R. Mitchell (Austin, Texas); Chris W. Mann (Austin, Texas); Alexander P. Greis (Austin, Texas) |
| ABSTRACT | An apparatus comprises a housing defining a chamber that has a liquid disposed therein, and a sensor submerged in the liquid. The sensor comprises a porous conductive film on a substrate, and the film comprises chemiresistive semiconducting metal oxide structures. The sensor also comprises an electrode pair operably connected to the porous conductive film for generating electric current in the film and for detecting a change in an electrical property of the film. The apparatus can be used to detect, identify, and quantify ions and molecules in a liquid sample. Molecules and ions, in a liquid sample, that interact with the porous conductive film can cause a change in an electrical property of the film. The change in electrical property of the film can be correlated with the presence and amount of the molecules or ions. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/412679 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0606 (20130101) Original (OR) Class G01N 15/0656 (20130101) G01N 2015/0053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389296 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peiming Zhang (Gilbert, Arizona); Sovan Biswas (Tempe, Arizona); Suman Sen (Tempe, Arizona); Stuart Lindsay (Phoenix, Arizona) |
| ABSTRACT | The present disclosure provides apparatus and methods for determining the sequence of a nucleic acid. The apparatus comprises electrodes that form a tunnel gap through which the nucleic acid can pass. The electrodes comprise a reagent that is capable of selectively interacting with a nucleobase of the nucleic acid sequence. When the reagent interacts with a nucleobase, a detectable signal is produced and used to identify the nucleobase of the nucleic acid. Advantageously, the apparatus of this disclosure is specific to identifying nucleic acids. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/460005 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 321/10 (20130101) C07C 2603/50 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389301 | Spranger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Stefani Spranger (Boston, Massachusetts); Ellen Duong (Quincy, Massachusetts) |
| ABSTRACT | Provided herein are compositions and methods of use relating to a novel class of dendritic cells, referred to herein as ISG+ DC, having anti-tumor activity. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348704 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) G01N 33/5047 (20130101) Original (OR) Class G01N 33/6893 (20130101) G01N 33/57492 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389302 | McKay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian S. McKay (Tucson, Arizona); Anna G. Figueroa (Tucson, Arizona); Nicole R. Congrove (Tucson, Arizona) |
| ABSTRACT | Methods and systems for screening therapeutic compositions for the treatment of age-related macular degeneration (AMD) or for the prevention of progression of AMD, wherein retinal pigment epithelium cells (RPE) are cultured and the level of hypoxia-induced exosome release from the RPE cells is subsequently measured. In the present invention, the level of hypoxia-induced exosome release can be correlated with AMD onset and severity. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345718 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 33/5058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389303 | Brafman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | David Brafman (Phoenix, Arizona); Xiao Wang (Chandler, Arizona); Nicholas Brookhouser (Tempe, Arizona); Stefan Tekel (Tempe, Arizona); Kylie Standage-Beier (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Brafman (Phoenix, Arizona); Xiao Wang (Chandler, Arizona); Nicholas Brookhouser (Tempe, Arizona); Stefan Tekel (Tempe, Arizona); Kylie Standage-Beier (Phoenix, Arizona) |
| ABSTRACT | Provided herein are compositions and methods for real-time identification and isolation of base-edited cell populations. Also provided herein are methods for producing enriched isogenic lines of genetically modified cells, including base-edited human pluripotent stem cells. In particular, provided herein are methods utilizing transient expression of reporter proteins, the detectable signal of which is altered following base editing. Using the transient reporter with a base editor permits enrichment of isogenic populations of base-edited cells. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/347360 |
| CURRENT CPC | Peptides C07K 14/43595 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5073 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389319 | Walston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy D. Walston (Baltimore, Maryland); Peter M. Abadir (Woodstock, Maryland); Alka Jain (Columbia, Maryland); Neal Fedarko (Columbia, Maryland) |
| ABSTRACT | The invention described herein provides methods for treating a disease or disorder associated with angiotensin receptor signaling in a patient exhibiting elevated levels of ATIR autoantibodies. The invention also provides methods of identifying a patient suffering from a disease or disorder associated with angiotensin receptor signaling that may benefit from treatment with an angiotensin receptor blocker. Patients with elevated levels of ATIR autoantibodics are identified as candidates that particularly benefit from treatment with an angiotensin receptor blocker. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458613 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) A61K 31/513 (20130101) A61K 31/4178 (20130101) A61K 31/4184 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389332 | Apte et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajendra S. Apte (St. Louis, Missouri); Jun Yoshino (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provided methods for determining the severity of glaucoma using the expression levels of GDF15. Determining the severity of glaucoma aids in treatment decisions. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/411863 |
| CURRENT CPC | Peptides C07K 14/475 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2333/52 (20130101) G01N 2800/52 (20130101) G01N 2800/168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389483 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Xin LI (Tucson, Arizona); Lars FURENLID (Tucson, Arizona) |
| ABSTRACT | Disclosed are fast gamma-ray interaction-position estimation methods using k-d tree searching. Compared with conventional methods, the methods disclosed herein achieve both high levels of speed and accuracy using k-d tree data structures. The k-d tree search methods have a time complexity of O(log x(N)), where x is the number of branches at each node and N is the number of entries in the reference data set, which means larger reference datasets can be used to efficiently estimate each event's interaction position. The accuracy of methods described herein was found to be equal to the exhaustive search method, yielding the highest achievable accuracy. Most importantly, the disclosed methods have no restriction on the data structure of the reference dataset and can work with complicated mean detector response functions (MDRFs), meaning it is more robust compared with other methods such as contracting grid (CG) search or vector search (VS) methods. |
| FILED | Friday, October 18, 2019 |
| APPL NO | 17/286727 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/037 (20130101) Measurement of Nuclear or X-radiation G01T 1/2006 (20130101) G01T 1/2985 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210390709 — SYSTEM AND METHOD TO IMPROVE MODEL-BASED ORGAN SEGMENTATION WITH IMAGE POST-PROCESSING
| US 20210390709 | Feng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xue Feng (Lexington, Kentucky); Quan Chen (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xue Feng (Lexington, Kentucky); Quan Chen (Lexington, Kentucky) |
| ABSTRACT | The present disclosure relates to a method and apparatus to improve model-based organ segmentation with image post-processing using one or more processors. The method includes: receiving three-dimensional (3D) voxel-by-voxel segmentation results as the output of a segmentation model based on 3D computed tomography (CT) or magnetic resonance (MR) images; analyzing the segmentation results on a 3D basis; processing the results to identify regions with anatomically incorrect segmentations; fixing the incorrect segmentations; analyzing the remaining segmentation results on a slice-by-slice basis; processing the results to identify slices with anatomically incorrect segmentations; fixing the incorrect segmentations to obtain the final results. |
| FILED | Tuesday, June 16, 2020 |
| APPL NO | 16/903299 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/005 (20130101) G06T 7/11 (20170101) G06T 7/174 (20170101) Original (OR) Class G06T 2207/10012 (20130101) G06T 2207/10072 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391754 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Joshua R. Smith (Seattle, Washington); Benjamin Waters (Seattle, Washington) |
| ABSTRACT | A wireless power transfer system includes a transmitter configured to transmit power to a receiver, for example, through coupled resonators. The transmitter receives feedback from the receiver, and uses the feedback to control the power transmission, to control a parameter at the receiver, for example, a rectified voltage output by the receiver. The feedback to the transmitter may be provided, for example, by an out-of-band radio system between the transmitter and receiver, by a reflection coefficient at the transmitter, and/or by an encoded modulation of power in the receiver, for example, in an impedance matching module. The transmitter may control the transmitted power, for example, by controlling a transmitter signal generator voltage (VSIG), a transmitter gate driver voltage (VGD), a transmitter amplifier voltage (VPA), and/or an impedance setting in a transmitter impedance matching module. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461885 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/10 (20160201) Original (OR) Class H02J 50/12 (20160201) H02J 50/80 (20160201) Transmission H04B 5/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210386497 | Zhao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanhe Zhao (Allston, Massachusetts); Yoonho Kim (Cambridge, Massachusetts) |
| ABSTRACT | Robotic devices and methods for performing minimally invasive procedures on the vascular system, particularly cerebrovascular and endovascular neurosurgical procedures, where a submillimeter-scale continuum robotic device is configured and adapted for active steering and navigation based on external magnetic actuation. The submillimeter-scale continuum robotic device includes an elongate body having an inner core and an outer shell, where the outer shell is fabricated of an elastomeric material having a plurality of ferromagnetic particles dispersed therein. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/458114 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/20 (20160201) A61B 34/71 (20160201) A61B 34/73 (20160201) Original (OR) Class A61B 2090/306 (20160201) Manipulators; Chambers Provided With Manipulation Devices B25J 9/1682 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386575 | Blanck |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States As Represented By the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | The Government of the United States As Represented By the Secretary of the Army (Fort Detrick, Maryland) |
| INVENTOR(S) | Ryan V. Blanck (Gig Harbor, Washington) |
| ABSTRACT | An exoskeletal orthosis includes a proximal cuff including a hinge along an upper edge of the cuff; an ankle section/footplate; and at least one posterior strut connecting the proximal cuff to the ankle section and foot plate. |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/462179 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/0125 (20130101) A61F 5/0127 (20130101) Original (OR) Class A61F 2005/0179 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386848 | Ficht et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. Ficht (College Station, Texas); Allison Ficht (College Station, Texas); Renee Tsolis (Davis, California); Leslie Garry Adams (College Station, Texas); Angela M. Arenas-Gamboa (College Station, Texas) |
| ABSTRACT | Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to vaccines. In additional embodiments, the invention relates to formulations capable of releasing said vaccines at a controlled rate of release in vivo. In further embodiments, the invention relates to modified strains of the bacteria Brucella melitensis and Brucella abortus. In still further embodiments, the invention relates to compositions that do not induce clinical symptoms or splenomegaly in a subject receiving said compositions. |
| FILED | Monday, January 18, 2021 |
| APPL NO | 17/151488 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/098 (20130101) Original (OR) Class A61K 2039/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386875 | Achilefu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Achilefu (St. Louis, Missouri); Kvar Black (St. Louis, Missouri) |
| ABSTRACT | The present invention encompasses compositions comprising two spectrally distinct radionuclides separated by a site susceptible to cleavage. Compositions of the invention may be used to detect enzyme activity and/or image diseases associated with said enzyme activity. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319780 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/088 (20130101) Original (OR) Class A61K 51/1251 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386986 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); Industry University Cooperation Foundation Hanyang Universiity (Seoul, South Korea) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chi Hwan Lee (West Lafayette, Indiana); Yoon Yeo (West Lafayette, Indiana); Dong Rip Kim (Seoul, South Korea) |
| ABSTRACT | Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344362 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class A61M 2037/0023 (20130101) A61M 2037/0053 (20130101) A61M 2205/0244 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387033 | Ananth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Ramagopal Ananth (Bryn Mawr, Pennsylvania); Arthur W. Snow (Alexandria, Virginia); Katherine Hinnant (Washington, District of Columbia); Spencer L. Giles (Lorton, Virginia) |
| ABSTRACT | Disclosed is a firefighting composition of the surfactants below and water. The values of m, n, x, and y are independently selected positive integers. R is an organic group. R′ is a siloxane group. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458887 |
| CURRENT CPC | Fire-fighting A62C 5/02 (20130101) Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 1/0071 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387327 | Kornbluh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roy David Kornbluh (Palo Alto, California); Alexander Steele Kernbaum (Sunnyvale, California); Thomas Low (Belmont, California); Katherine Goss Witherspoon (San Francisco, California); Brian Keith McCoy (Sunnyvale, California); Adam Arnold Edward Ziemba (Menlo Park, California); Paul Michael Birkmeyer (Redwood City, California); Richard M. Mahoney (Los Altos, California) |
| ABSTRACT | A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/146085 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) Original (OR) Class B25J 9/104 (20130101) B25J 9/1615 (20130101) B25J 9/1633 (20130101) Couplings for Transmitting Rotation; Clutches; Brakes F16D 28/00 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 2219/36429 (20130101) G05B 2219/39345 (20130101) G05B 2219/40305 (20130101) Information and Communication Technology [ICT] Specially Adapted for Specific Application Fields, Not Otherwise Provided for G16Z 99/00 (20190201) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/02 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49826 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387719 | Rubin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart H. Rubin (San Diego, California) |
| ABSTRACT | A vehicle includes a surface for contacting a fluid medium through which the vehicle is propelled. The vehicle also includes an array of transducers and a controller. The transducers in the array are arranged across the vehicle's surface for generating pressure waves in the fluid medium. Each transducer in the array is arranged to vibrate for generating a respective pressure wave, which propagates away from the surface in the fluid medium. The controller vibrates the transducers in the array so that the pressure waves control the drag of the vehicle from the fluid medium. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 16/898061 |
| CURRENT CPC | Ships or Other Waterborne Vessels; Equipment for Shipping B63B 1/34 (20130101) Aeroplanes; Helicopters B64C 23/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388052 | Zang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| ASSIGNEE(S) | ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York) |
| INVENTOR(S) | Xingxing Zang (New York, New York); Jordan M. Chinai (Bronx, New York); Murali Janakiram (Brooklyn, New York); Steven C. Almo (Pelham, New York); Andras Fiser (New York, New York) |
| ABSTRACT | Provided are methods of treating an HHLA2-bearing tumor in a subject with a fusion protein comprising an IgV-like domain of a TMIGD2 sufficient to treat the HHLA2-bearing tumor. A fusion protein comprising an IgV-like domain of a TMIGD2 and related compositions and encoding nucleic acids are also provided. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140996 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/70503 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388066 | WESTENDORF et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| ASSIGNEE(S) | AbCellera Biologics Inc. (Vancouver, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Svcs. (Bethesda, Maryland) |
| INVENTOR(S) | Kathryn WESTENDORF (Vancouver, Canada); Stefanie ZENTELIS (Vancouver, Canada); Krithika MUTHURAMAN (Toronto, Canada); Kevin JEPSON (Vancouver, Canada); Ester FALCONER (Vancouver, Canada); John MASCOLA (Bethesda, Maryland); Barney GRAHAM (Bethesda, Maryland); Kizzmekia CORBETT (Bethesda, Maryland); Julie LEDGERWOOD (Bethesda, Maryland); Lingshu WANG (Bethesda, Maryland); Olubukola ABIONA (Bethesda, Maryland); Wei SHI (Bethesda, Maryland); Wing-pui KONG (Bethesda, Maryland); Yi ZHANG (Bethesda, Maryland); Bryan Edward JONES (San Diego, California); Denisa FOSTER (San Diego, California); Julian DAVIES (La Jolla, California); Qing CHAI (San Diego, California); Christopher Carl FRYE (Bargersville, Indiana); Ganapathy GOPALRATHNAM (Fishers, Indiana); Jörg HENDLE (San Diego, California); John Michael SAUDER (Carlsbad, California); Jeffrey Streetman BOYLES (Indianapolis, Indiana); Anna PUSTILNIK (San Diego, California) |
| ABSTRACT | Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354434 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 47/6801 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/10 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388068 | KLEMPNER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark S.J. KLEMPNER (Boston, Massachusetts); Yang WANG (Wellesley, Massachusetts); Serena GIUNTINI (Belmont, Massachusetts) |
| ABSTRACT | The invention provides anti-CfaE antibodies and methods of using the same. |
| FILED | Tuesday, November 12, 2019 |
| APPL NO | 17/292078 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 16/1232 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388080 | Rohrer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of The University of Colorado, A Body Corporate (Denver, Colorado); MUSC Foundation For Research Development (Charleston, South Carolina); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baerbel M. Rohrer (Charleston, South Carolina); V. Michael Holers (Denver, Colorado); Stephen Tomlinson (Charleston, South Carolina); Joshua M. Thurman (Greenwood Village, Colorado); Carl Atkinson (Mount Pleasant, South Carolina); Liudmila Kulik (Aurora, Colorado) |
| ABSTRACT | The present invention provides targeted delivery methods and constructs for treating inflammatory diseases and/or detecting in vivo tissue injuries in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The invention also provides methods of inhibiting complement-driven inflammation in the eye in an individual, comprising administering to the individual an antibody or a fragment thereor or compositions thereof, wherein the antibody or fragment thereof specifically binds to Annexin IV or phospholipid. Also provided are related methods of treating a complement-associated ocular disease or an ocular disease involving oxidative damage. Additionally, the invention provides methods of detecting complement-mediated injury in an eye tissue of an individual, comprising administering to the individual a construct or compositions thereof, wherein the construct comprises (a) an antibody or fragment thereof that specifically binds to Annexin IV or phospholipid; and (b) a detectable moiety. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228279 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388093 | Miller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey S. Miller (Minneapolis, Minnesota); Martin Felices (Minneapolis, Minnesota); Daniel A. Vallera (Minneapolis, Minnesota); Todd R. Lenvik (Minneapolis, Minnesota) |
| ABSTRACT | Provided are compositions for activating NK cells to stimulate an immune response for treating cancer and other disorders. In one embodiment, the invention provides a compound comprising an NK engaging domain that binds to CD 16; an NK activating domain operably linked to the NK engaging domain; and a targeting domain that selectively binds to a target cell and is operably linked to the NK activating domain and the NK engaging domain, wherein the targeting domain binds to CLEC12A. |
| FILED | Thursday, October 17, 2019 |
| APPL NO | 17/285447 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) C07K 16/283 (20130101) C07K 16/2851 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/24 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388162 | Martin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett D. Martin (Washington, District of Columbia); Jeffrey R. Deschamps (Washington, District of Columbia); Jeffrey C. DePriest (Washington, District of Columbia); Ian D. Giles (Alexandria, Virginia) |
| ABSTRACT | A new, thermally stable conducting material, poly(3-amino-1H-pyrazole-4-carboxylate), can be used in a variety of applications such as thermoelectrics, electron acceptors in light-harvesting (photovoltaic) materials, and thermally stable conducting energetic materials. Related compounds include poly 3-amino-5-chloro-1H-pyrazole-4-carboxylate, poly 3-amino-5-bromo-1H-pyrazole-4-carboxylate, poly 3-amino-5-fluoro-1H-pyrazole-4-carboxylate, poly 3-amino-5-iodo-1H-pyrazole-4-carboxylate, poly 3, 5-diamino-1H-pyrazole-4-carboxylate, poly 3-amino-5-NHR1-1H-pyrazole-4-carboxylate, poly 3-amino-5-NR2-1H-pyrazole-4-carboxylate, or poly 3-amino-5-hydroxy-1H-pyrazole-4-carboxylate. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/347050 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388164 | ALLEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Josephine ALLEN (Gainesville, Florida); Vidhya RAMASWAMY (Plymouth, Minnesota); Krista DULANY (Boca Raton, Florida); Allison N. GOINS (Marietta, Georgia) |
| ABSTRACT | Described herein are methods of preparing protein scaffolds that can include the step of crosslinking protein fibers in the vapor phase of a natural aldehyde, such as cinnamaldehyde or vanillin or a solution thereof. Also described herein are protein scaffolds that can be prepared by a method that can include the step of crosslinking protein fibers in the vapor phase of a natural aldehyde solution, such as cinnamaldehyde or vanillin or a solution thereof. |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 17/281714 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/222 (20130101) A61L 27/227 (20130101) A61L 2400/12 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) Original (OR) Class C08J 2389/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388268 | Guin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Tyler C. Guin (Aiken, South Carolina); Timothy J White (Longmont, Colorado) |
| ABSTRACT | A shape-programmable liquid crystal elastomer. The elastomer comprising cross-linked and polymerized nematic, isotropic monomers with carbon nanotubes that are organized into a plurality of voxels. Each voxel has a director orientation such that each voxel of the plurality has a first state according to the director orientation and a second state according to cross-linkages of the polymerized nematic monomers. The elastomer transitions between the first and second states with exposure to an electric field. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/460669 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/56 (20130101) C09K 19/3852 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388301 | INGBER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald E. INGBER (Boston, Massachusetts); Anthony BAHINSKI (Wilmington, Delaware); Robert CUNNINGHAM (Cohasset, Massachusetts); Josue A. GOSS (Somerville, Massachusetts); Geraldine A. HAMILTON (Cambridge, Massachusetts); Christopher David HINOJOSA (Cambridge, Massachusetts); Daniel LEVNER (Boston, Massachusetts); Kevin Kit PARKER (Waitham, Massachusetts) |
| ABSTRACT | The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems. |
| FILED | Monday, January 11, 2021 |
| APPL NO | 17/146264 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/02 (20130101) A01N 1/021 (20130101) A01N 1/0247 (20130101) A01N 1/0273 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 3/502715 (20130101) B01L 9/52 (20130101) B01L 2200/146 (20130101) B01L 2200/147 (20130101) B01L 2200/0684 (20130101) B01L 2200/0689 (20130101) B01L 2300/18 (20130101) B01L 2300/044 (20130101) B01L 2300/123 (20130101) B01L 2300/0636 (20130101) B01L 2300/0654 (20130101) B01L 2300/0663 (20130101) B01L 2300/0867 (20130101) B01L 2300/0877 (20130101) B01L 2400/0487 (20130101) B01L 2400/0622 (20130101) B01L 2400/0644 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 23/42 (20130101) C12M 29/10 (20130101) C12M 35/04 (20130101) C12M 35/08 (20130101) C12M 41/00 (20130101) C12M 41/12 (20130101) C12M 41/46 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) G01N 33/5082 (20130101) G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388337 | Murata et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hironobu Murata (Pittsburgh, Pennsylvania); Alan J. Russell (Pittsburgh, Pennsylvania) |
| ABSTRACT | This document relates to materials and methods for using controlled radical polymerization (e.g., atom transfer radical polymerization) to generate protein-polymer conjugates in which two or more polymer molecules are attached to individual initiator molecules on the protein. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/284837 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/58 (20170801) A61K 47/60 (20170801) A61K 47/62 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/96 (20130101) Original (OR) Class C12N 11/087 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388383 | Andreassen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul R. Andreassen (Cincinnati, Ohio); Helmut Hanenberg (Duesseldorf, Germany) |
| ABSTRACT | Disclosed herein are compositions and methods for the expression of a gene of interest. The disclosed methods may employ codon-optimization and introduction of non-endogenous restriction sites for efficient expression of a gene. The methods may further employ introduction of a gene variant of interest, such that the disclosed methods, compositions, and systems may be used to determine the significance of a variant of interest. Further disclosed are compositions, systems, and methods for the characterization of gene variants, and other mutations that may impact the function of the protein of interest. |
| FILED | Friday, October 11, 2019 |
| APPL NO | 17/283361 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388430 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David Yu Zhang (Cambridge, Massachusetts); Peng Yin (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are primers and primer systems having improved specificity and kinetics over existing primers, and methods of use thereof. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/169145 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6832 (20130101) C12Q 1/6848 (20130101) C12Q 1/6853 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388443 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Institute for Systems Biology (Seattle, Washington); The Secretary of State for Defence (Salisbury, United Kingdom) |
| ASSIGNEE(S) | Institute for Systems Biology (Seattle, Washington); The Secretary of State for Defence (Salisbury, United Kingdom) |
| INVENTOR(S) | Kai Wang (Seattle, Washington); Taek-Kyun Kim (Seattle, Washington); Minyoung Lee (Seattle, Washington); Kathie Walters (Seattle, Washington); Roman Anton Lukaszewski (Salisbury, United Kingdom) |
| ABSTRACT | Methods for diagnosing and/or predicting presence of sepsis in a subject using a gene signature of three or more genes are provided. Also provided are sets containing specific binding molecules for each of the three or more genes, and kits containing such sets. |
| FILED | Monday, November 04, 2019 |
| APPL NO | 17/290931 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388498 | Eden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Gary Eden (Champaign, Illinois); Sung-Jin Park (Urbana, Illinois); Andrey Mironov (Urbana, Illinois); Jinhong Kim (Urbana, Illinois) |
| ABSTRACT | An in-chamber plasma source in a deposition reactor system includes an array of microcavity or microchannel plasma devices having a first electrode and a second electrode isolated from plasma in microcavities or microchannels. An inlet provides connection to deposition precursor. A region interacts deposition precursor with plasma. An outlet directs precursor dissociated with the plasma onto a substrate for deposition. A reactor system includes a substrate holder across from the outlet, a chamber enclosing the in-chamber plasma source and the substrate holder, an exhaust from the chamber, and conduit supplying precursors from sources or bubblers to the inlet. A reactor system can conduct plasma enhanced atomic layer deposition at high pressures and is capable of forming a complete layer in a single cycle. |
| FILED | Tuesday, October 15, 2019 |
| APPL NO | 17/285182 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/403 (20130101) C23C 16/482 (20130101) C23C 16/5093 (20130101) C23C 16/45538 (20130101) C23C 16/45544 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 37/32715 (20130101) H01J 2237/332 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0228 (20130101) H01L 21/02175 (20130101) H01L 21/02178 (20130101) H01L 21/02205 (20130101) H01L 21/02274 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388526 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongping Zhao (Columbus, Ohio); A F M Anhar Uddin Bhuiyan (Columbus, Ohio); Zixuan Feng (Columbus, Ohio) |
| ABSTRACT | Disclosed herein methods of forming an Al—Ga containing film comprising: a) exposing a substrate comprising a β-Ga2O3, wherein the substrate has a (100) or (−201) orientation, to a vapor phase comprising an aluminum precursor and a gallium precursor; and b) forming a β-(AlxGa1-x)2O3 thin film by a chemical vapor deposition at predetermined conditions and wherein x is 0.01≤x≤0.7. Also disclosed herein are devices comprising the inventive films. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231382 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/165 (20130101) C30B 25/183 (20130101) C30B 25/186 (20130101) C30B 29/22 (20130101) Original (OR) Class C30B 29/68 (20130101) C30B 31/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388869 | Powell, JR. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Johnny F Powell, JR. (Aberdeen Proving Ground, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Johnny F Powell, JR. (Aberdeen Proving Ground, Maryland) |
| ABSTRACT | The Hub Saver has a planar body formed of a sheet of resilient metal or material having a selected thickness between top and bottom surfaces to allow sufficient engagement of the axle spindle thread with which it is to be used and the compression washer, castle-nut, and cotter pin. The bolt circle pattern of smaller holes allows ample grease to the bearing assembly, should a greasing device be used. The outer diameter, inner diameter as well as the bolt circle diameter and placement, will vary depending upon the diameter of the respective spindles and races for the various bearing sizes. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/194172 |
| CURRENT CPC | Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 19/548 (20130101) F16C 35/08 (20130101) Original (OR) Class F16C 2326/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389126 | Gallagher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | James C. Gallagher (Alexandria, Virginia); Travis J. Anderson (Alexandria, Virginia); Jennifer K. Hite (Arlington, Virginia); Karl D. Hobart (Alexandria, Virginia) |
| ABSTRACT | An improved method for evaluating GaN wafers. RMS analysis of wafer heights obtained by optical interferometric profilometry is combined with an extreme Studentized deviate (ESD) analysis to obtain a map of the wafer surface that more accurately identifies areas on the surface of a GaN wafer having defects that making those areas unsuitable for fabrication of a vertical electronic device thereon such as bumps and/or pits that can lower the breakdown voltage, increase the on-resistance, and increase the ideality factor. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345012 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/303 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389128 | Strandjord et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | Lee K. Strandjord (Tonka Bay, Minnesota); Norman Gerard Tarleton (Glendale, Arizona); Chuck Croker (Glendale, Arizona) |
| ABSTRACT | Systems and methods are provided to reduce at least one differential harmonics of a resonance tracking modulation in a resonant fiber optic gyroscope (RFOG). The fundamental frequency of the resonance tracking modulation of each of the clockwise and counter clockwise optical signals is substantially identical; however, the amplitude and phase of the Nth harmonic of a clockwise (CW) resonance tracking modulation and the Nth harmonic of a clockwise (CCW) resonance tracking modulation may differ due to non-linearities in the RFOG. Embodiments of the invention diminish, e.g., reduce to zero such vectoral difference. Differential harmonics may be generated at one or more harmonics. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 16/900419 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/721 (20130101) G01C 19/727 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389222 | Savoy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nanohmics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Nanohmics, Inc. (Austin, Texas) |
| INVENTOR(S) | Steve M. Savoy (Austin, Texas); Elzbieta A. Ledwosinska (Austin, Texas); Jeremy J. John (Austin, Texas); Kyle W. Hoover (Austin, Texas); Daniel R. Mitchell (Austin, Texas); Chris W. Mann (Austin, Texas); Alexander P. Greis (Austin, Texas) |
| ABSTRACT | An apparatus comprises a housing defining a chamber that has a liquid disposed therein, and a sensor submerged in the liquid. The sensor comprises a porous conductive film on a substrate, and the film comprises chemiresistive semiconducting metal oxide structures. The sensor also comprises an electrode pair operably connected to the porous conductive film for generating electric current in the film and for detecting a change in an electrical property of the film. The apparatus can be used to detect, identify, and quantify ions and molecules in a liquid sample. Molecules and ions, in a liquid sample, that interact with the porous conductive film can cause a change in an electrical property of the film. The change in electrical property of the film can be correlated with the presence and amount of the molecules or ions. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/412679 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0606 (20130101) Original (OR) Class G01N 15/0656 (20130101) G01N 2015/0053 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389241 | Meyer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Governement of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jerry R. Meyer (Catonsville, Maryland); Igor Vurgaftman (Severna Park, Maryland); Chadwick Lawrence Canedy (Washington, District of Columbia); William W. Bewley (Falls Church, Virginia); Chul Soo Kim (Springfield, Virginia); Charles D. Merritt (Fairfax, Virginia); Michael V. Warren (Arlington, Virginia); R. Joseph Weiblen (Washington, District of Columbia); Mijin Kim (Springfield, Virginia) |
| ABSTRACT | Building blocks are provided for on-chip chemical sensors and other highly-compact photonic integrated circuits combining interband or quantum cascade lasers and detectors with passive waveguides and other components integrated on a III-V or silicon. A MWIR or LWIR laser source is evanescently coupled into a passive extended or resonant-cavity waveguide that provides evanescent coupling to a sample gas (or liquid) for spectroscopic chemical sensing. In the case of an ICL, the uppermost layer of this passive waveguide has a relatively high index of refraction that enables it to form the core of the waveguide, while the ambient air, consisting of the sample gas, functions as the top cladding layer. A fraction of the propagating light beam is absorbed by the sample gas if it contains a chemical species having a fingerprint absorption feature within the spectral linewidth of the laser emission. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407212 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/1895 (20130101) G01J 3/2803 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/27 (20130101) G01N 21/59 (20130101) Original (OR) Class G01N 21/255 (20130101) G01N 2201/0612 (20130101) Optical Elements, Systems, or Apparatus G02B 6/102 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/101 (20130101) H01S 5/125 (20130101) H01S 5/0215 (20130101) H01S 5/0262 (20130101) H01S 5/0287 (20130101) H01S 5/343 (20130101) H01S 5/0421 (20130101) H01S 5/0612 (20130101) H01S 5/2063 (20130101) H01S 5/2206 (20130101) H01S 5/3402 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389242 | Meyer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jerry R. Meyer (Catonsville, Maryland); Igor Vurgaftman (Severna Park, Maryland); Chadwick Lawrence Canedy (Washington, District of Columbia); William W. Bewley (Falls Church, Virginia); Chul Soo Kim (Springfield, Virginia); Charles D. Merritt (Fairfax, Virginia); Michael V. Warren (Arlington, Virginia); R. Joseph Weiblen (Washington, District of Columbia); Mijin Kim (Springfield, Virginia) |
| ABSTRACT | Building blocks are provided for on-chip chemical sensors and other highly-compact photonic integrated circuits combining interband or quantum cascade lasers and detectors with passive waveguides and other components integrated on a III-V or silicon. A MWIR or LWIR laser source is evanescently coupled into a passive extended or resonant-cavity waveguide that provides evanescent coupling to a sample gas (or liquid) for spectroscopic chemical sensing. In the case of an ICL, the uppermost layer of this passive waveguide has a relatively high index of refraction that enables it to form the core of the waveguide, while the ambient air, consisting of the sample gas, functions as the top cladding layer. A fraction of the propagating light beam is absorbed by the sample gas if it contains a chemical species having a fingerprint absorption feature within the spectral linewidth of the laser emission. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407263 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/1895 (20130101) G01J 3/2803 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/27 (20130101) G01N 21/59 (20130101) Original (OR) Class G01N 21/255 (20130101) G01N 2201/0612 (20130101) Optical Elements, Systems, or Apparatus G02B 6/102 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/101 (20130101) H01S 5/125 (20130101) H01S 5/0215 (20130101) H01S 5/0262 (20130101) H01S 5/0287 (20130101) H01S 5/343 (20130101) H01S 5/0421 (20130101) H01S 5/0612 (20130101) H01S 5/2063 (20130101) H01S 5/2206 (20130101) H01S 5/3402 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389265 | Stein et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Analog Devices International Unlimited Company (Limerick, Ireland); Analog Devices, Inc. (Wilmington, Massachusetts) |
| ASSIGNEE(S) | Analog Devices International Unlimited Company (Limerick, Ireland); Analog Devices, Inc. (Wilmington, Massachusetts) |
| INVENTOR(S) | Yosef Stein (Sharon, Massachusetts); Seth S. Kessler (Newton, Massachusetts); Haim Primo (Ganei Tikva, Israel) |
| ABSTRACT | Aspects of the present application allow for measurement of a calibrated resistance for a resistive film in a sensing element, such that effects from contact resistance and background resistance drifts due to factors such as temperature, strain or aging can be reduced or eliminated. In some embodiments, by taking a plurality of two-terminal resistance measurements between various pairs of electrodes on a resistive film, a contact-resistance-independent resistance of a reference portion of the resistive film can be determined. Further, a contact-resistance-independent resistance of a sensing portion of the resistive film can be determined based on a plurality of two-terminal resistance measurements between pairs of electrodes. The resistance of the reference portion can be removed from the measured resistance of the sensing portion, such that variations in the reference portion resistance that are not caused by a sensed environmental condition may be compensated. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/346049 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389317 | Roy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Orono Spectral Solutions, Inc. (Bangor, Maine) |
| ASSIGNEE(S) | Orono Spectral Solutions, Inc. (Bangor, Maine) |
| INVENTOR(S) | Eric Roy (Lisbon Falls, Maine); Rachel Gettings (Bangor, Maine); Luke Doucette (Hampden, Maine) |
| ABSTRACT | An apparatus for capturing a target analyte in advance of performing spectroscopic analysis to determine the existence of the target analyte from a source contacted with a collection substrate. The collection substrate is fabricated of a material selected to have an affinity for the target analyte, sufficiently transparent in a spectral region of interest and capable of immobilizing the target analyte thereon in a manner that limits scattering sufficient to obscure spectral analysis. The collection substrate may be coated with a material selected to react with, bind to, or absorb the target analyte. The target analyte may be captured to the collection substrate by one or more of wiping, dabbing or swabbing a target analyte carrier with the collection substrate. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208891 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5029 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/02 (20130101) G01N 1/04 (20130101) G01N 21/3563 (20130101) G01N 33/54373 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389319 | Walston et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy D. Walston (Baltimore, Maryland); Peter M. Abadir (Woodstock, Maryland); Alka Jain (Columbia, Maryland); Neal Fedarko (Columbia, Maryland) |
| ABSTRACT | The invention described herein provides methods for treating a disease or disorder associated with angiotensin receptor signaling in a patient exhibiting elevated levels of ATIR autoantibodies. The invention also provides methods of identifying a patient suffering from a disease or disorder associated with angiotensin receptor signaling that may benefit from treatment with an angiotensin receptor blocker. Patients with elevated levels of ATIR autoantibodics are identified as candidates that particularly benefit from treatment with an angiotensin receptor blocker. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458613 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) A61K 31/513 (20130101) A61K 31/4178 (20130101) A61K 31/4184 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) Original (OR) Class G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389321 | Kaushik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sumanth Kaushik (Belmont, Massachusetts); Jeffrey Karp (Brookline, Massachusetts); Charles Wynn (Groton, Massachusetts); Anthony Samir (Newton, Massachusetts) |
| ABSTRACT | A system and method is provided for detecting an analyte within a sample. The method includes providing a first electromagnetic radiation to the sample in a manner that resonantly excites mechanical vibrations in the analyte. The method also includes providing a second electromagnetic radiation to the sample so as to interact with vibrating analyte, wherein a third electromagnetic radiation is produced based on the interaction. The method further includes receiving the a third electromagnetic radiation and determining the presence of the analyte based on the received a third electromagnetic radiation. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/339889 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 22/00 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2201/068 (20130101) G01N 2201/06113 (20130101) G01N 2333/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389324 | Legler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patricia M. Legler (Derwood, Maryland); Elaine Morazzani (Leesburg, Virginia); Pamela Glass (Frederick, Maryland) |
| ABSTRACT | Proteases of Group IV (+)ssRNA viruses were found to act on a human sequences in addition to the viral sequences. The identity of the cleavable human sequences is disclosed. Detection of these sequences can act as a diagnostic of infection. It is contemplated that these findings could be employed to facilitate post-translational silencing at the level of protein (e.g., removal of existing proteins), thus serving as a protein analog to CRISPR/Cas9 and RNAi/RISC, and further to enable sequence-specific silencing of host functions without the modification of the host genome. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458812 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/11 (20130101) C12N 15/902 (20130101) C12N 2310/20 (20170501) C12N 2770/36111 (20130101) C12N 2770/36131 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) Original (OR) Class G01N 2333/181 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389451 | Barngrover et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Michael Barngrover (San Diego, California); Amin Mohammad Rahimi (San Diego, California); Jacoby Ryan Larson (Surprise, Arizona); Julian Yousif Raheema (El Cajon, California) |
| ABSTRACT | A system for localization includes a radar, a database, a simulator, a registrar, and a filter. The radar is positioned at a disposed location requiring localization. The radar generates a radar image scanning a proximity around the disposed location. The database stores features of a landmass. The simulator generates synthesized images of the features that the radar is predicted to generate from corresponding viewpoints. The registrar calculates respective correlation indicators between the radar image and each synthesized image. The filter sets a pose estimate of the disposed location to an average of those viewpoints from which correspond the synthesized images having the best or better ones of the correlation indicators. |
| FILED | Tuesday, June 16, 2020 |
| APPL NO | 16/902581 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/04 (20130101) G01S 13/86 (20130101) G01S 13/9021 (20190501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389601 | O'Toole et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew O'Toole (Pittsburgh, Pennsylvania); Mark Sheinin (Pittsburgh, Pennsylvania); Srinivasa Narasimhan (Pittsburgh, Pennsylvania) |
| ABSTRACT | A novel class of imaging systems that combines diffractive optics with 1D line sensing is disclosed. When light passes through a diffraction grating or prism, it disperses as a function of wavelength. This property is exploited to recover 2D and 3D positions from line images. A detailed image formation model and a learning-based algorithm for 2D position estimation are disclosed. The disclosure includes several extensions of the imaging system to improve the accuracy of the 2D position estimates and to expand the effective field-of-view. The invention is useful for fast passive imaging of sparse light sources, such as streetlamps, headlights at night and LED-based motion capture, and structured light 3D scanning with line illumination and line sensing. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178855 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/18 (20130101) G02B 27/0944 (20130101) G02B 27/4233 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389612 | Ram et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rajeev J. Ram (Arlington, Massachusetts); Marc De Cea Falco (Cambridge, Massachusetts); Jin Xue (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Rajeev J. Ram (Arlington, Massachusetts); Marc De Cea Falco (Cambridge, Massachusetts); Jin Xue (Cambridge, Massachusetts) |
| ABSTRACT | Semiconductor optical modulators are described that utilize bipolar junction transistor (BJT) structure within the optical modulator. The junctions within the BJT can be designed and biased to increase modulator efficiency and speed. An optical mode may be located in a selected region of the BJT structure to improve modulation efficiency. The BJT structure can be included in optical waveguides of interferometers and resonators to form optical modulators. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/227457 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/025 (20130101) Original (OR) Class G02F 1/0153 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390229 | Mirzendehdel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amirmassoud Mirzendehdel (San Mateo, California); Morad Behandish (Mountain View, California); Saigopal Nelaturi (Mountain View, California) |
| ABSTRACT | A representation of an initial design domain, at least one subtractive tool assembly, machine degrees of freedom, and a termination criterion are used to iteratively generate intermediate part designs by redistributing the material within the design domain. A measure of inaccessibility of exteriors of the intermediate part designs by the at least one subtractive manufacturing tool assembly are generated. The measure of inaccessibility is used to inform generation of an intermediate part design at a next iteration. The iterative algorithm is terminated when the termination criterion is satisfied, the result of the iterative algorithm being a part design accessible for subtractive manufacturing. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 16/901187 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/02 (20141201) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4099 (20130101) Electric Digital Data Processing G06F 30/17 (20200101) G06F 30/23 (20200101) Original (OR) Class G06F 2111/04 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390288 | MITTAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trisha MITTAL (College Park, Maryland); Aniket BERA (Greenbelt, Maryland); Uttaran BHATTACHARYA (College Park, Maryland); Rohan CHANDRA (College Park, Maryland); Pooja GUHAN (College Park, Maryland); Dinesh MANOCHA (Greenbelt, Maryland) |
| ABSTRACT | Systems, methods, apparatuses, and computer program products for recognizing human emotion in images or video. A method for recognizing perceived human emotion may include receiving a raw input. The raw input may be processed to generate input data corresponding to at least one context. Features from the raw input data may be extracted to obtain a plurality of feature vectors and inputs. The plurality of feature vectors and the inputs may be transmitted to a respective neural network. At least some of the plurality of feature vectors may be fused to obtain a feature encoding. Additional feature encodings may be computed from the plurality of feature vectors via the respective neural network. A multi-label emotion classification of a primary agent may be performed in the raw input based on the feature encoding and the additional feature encodings. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/349732 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/46 (20130101) G06K 9/00335 (20130101) Original (OR) Class G06K 9/628 (20130101) G06K 9/629 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390396 | Fan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Jonathan Albert Fan (Palo Alto, California); Jiaqi Jiang (Stanford, California) |
| ABSTRACT | Systems and methods for generating designs in accordance with embodiments of the invention are illustrated. One embodiment includes a method for training a generator to generate designs. The method includes steps for generating a plurality of candidate designs using a generator, evaluating a performance of each candidate design of the plurality of candidate designs, computing a global loss for the plurality of candidate designs based on the evaluated performances, and updating the generator based on the computed global loss. |
| FILED | Thursday, July 11, 2019 |
| APPL NO | 17/259130 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/27 (20200101) G06F 2119/02 (20200101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390408 | Crandall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle Crandall (Alexandria, Virginia); Dustin Webb (Salt Lake City, Utah) |
| ABSTRACT | Systems and methods are provided for consensus driven learning (CDL) using machine learning (ML) to enable devices to learn a model on a data set that is distributed over several computational nodes in a decentralized manner. In an embodiment, local models are trained on local data and share model parameters in an asynchronous, decentralized, and distributed manner that imposes minimal restrictions on the topology of a communications network. Systems and methods using CDL in accordance with embodiments of the present disclosure do not require a central server to coordinate models like most conventional technologies, high bandwidth, or highly robust communication architecture between nodes. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/347150 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390444 | Puri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Shruti Puri (New Haven, Connecticut); Alexander Grimm (New Haven, Connecticut); Philippe Campagne-lbarcq (New Haven, Connecticut); Steven M. Girvin (Hamden, Connecticut); Michel Devoret (New Haven, Connecticut) |
| ABSTRACT | Techniques for performing quantum information processing using an asymmetric error channel are provided. According to some aspects, a quantum information processing includes a data qubit and an ancilla qubit, the ancilla qubit having an asymmetric error channel. The data qubit is coupled to the ancilla qubit. The ancilla qubit may be driven with a stabilizing microwave field to create the asymmetric error channel. |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/253460 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391521 | Taylor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick J. Taylor (Oakton, Virginia); Jay R. Maddux (Greenbelt, Maryland); Kimberly A. Olver (Ellicot City, Maryland); Sina Simingalam (McLean, Virginia) |
| ABSTRACT | Protective coating to prevent sublimation are disclosed. More particularly, the protective coatings comprise one or more alkaline earth halide materials, or mixtures thereof, to prevent sublimation. The alkaline earth halide material of the coating can be judiciously selected to match the coefficient of thermal expansion (CTE) of the material of the external surface of the underlying substrate coated. The protective coatings may be advantageous for protecting external surfaces of thermoelectric materials, parts and devices at high temperature to prevent sublimation and material loss. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 16/901138 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 35/10 (20130101) H01L 35/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391589 | Garsany et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Yannick Garsany (Severna Park, Maryland); Robert Atkinson, III (Winchester, Massachusetts); Benjamin Gould (Springfield, Virginia) |
| ABSTRACT | A fuel cell membrane electrode assembly having: a proton exchange membrane, an anode catalyst coating on one side of the membrane, and a cathode catalyst coating on the other side of the membrane. The cathode catalyst coating has at least two carbon catalyst layers, with a low porosity layer adjacent to a high porosity layer. The high porosity layers have a volume fraction that is higher than the volume fraction of the low porosity layers. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/349464 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/926 (20130101) H01M 4/8605 (20130101) H01M 8/1004 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210392737 | Altman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | David H. Altman (Framingham, Massachusetts); Christopher H. Peters (Stoneham, Massachusetts); Gregory P. Schaefer (McKinney, Texas); Philip M. Henault (Medway, Massachusetts); Darin J. Sharar (Silver Springs, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David H. Altman (Framingham, Massachusetts); Christopher H. Peters (Stoneham, Massachusetts); Gregory P. Schaefer (McKinney, Texas); Philip M. Henault (Medway, Massachusetts); Darin J. Sharar (Silver Springs, Maryland) |
| ABSTRACT | An electronic assembly including a thermal capacitor. An electronic substrate of the electronic assembly includes one or more insulating layers and one or more conductor layers provided along the one or more insulating layers. The one or more conductor layers including a conductive material. A shape memory thermal capacitor is received in the electronic substrate. The shape memory thermal capacitor includes a shape memory core including a shape memory material. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 16/900390 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0204 (20130101) Original (OR) Class H05K 3/00 (20130101) H05K 2201/10416 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210386055 | Guo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| INVENTOR(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico) |
| ABSTRACT | Zr-based MOF NPs for cryopreservation of cells including, for example, red blood cells. |
| FILED | Wednesday, October 30, 2019 |
| APPL NO | 17/309152 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class A01N 1/0284 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) B01J 20/28007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386072 | BERGER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| INVENTOR(S) | Bryan W. BERGER (Charlottesville, Virginia); Evan L. ECKERSLEY (Charlottesville, Virginia) |
| ABSTRACT | Antipathogenic polypeptides and related compounds and compositions that display antipathogenic activity, antifungal activity (i.e., act as fungicides), antialgal activity (i.e., act as algaecides), and/or enzymatic activity against chitin (i.e., degrade chitin) and/or polyglucuronic acid (i.e., degrade the polyglucuronic acid) are described. These antipathogenic polypeptides, as well the related compounds and compositions disclosed herein, can be used in protecting/treating products, including but not limited to agricultural products and water bodies (including drinking water), from pathogens, including fungi and algae, as well as generating pathogen-resistant products (particularly fungi-resistant and/or algae-resistant products). |
| FILED | Thursday, October 24, 2019 |
| APPL NO | 17/287410 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/50 (20200101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386307 | WU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland); NORTH CAROLNA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min WU (Clarksville, Maryland); Chau-Wai WONG (Apex, North Carolina); Mingliang CHEN (College Park, Maryland); Qiang ZHU (College Park, Maryland); Zachary LAZRI (Gaithersburg, Maryland) |
| ABSTRACT | Systems, methods, apparatuses, and computer program products for contact-free heart rate monitoring and/or measurement are provided. One method may include receiving video(s) that include visual frame(s) of individual(s) performing exercises, detecting some exposed skin from the video(s), and performing motion compensation to generate color signals for the exposed skin to precisely align frames of the exposed skin. The method may also include generating the color signals by estimating a skin color for each frame by taking a spatial average over pixels of a cheek of the face(s) for R, G, and B channels, respectively, applying an operation to remove remaining motion traces from the frames such that the heart rate traces dominate, and extracting and/or outputting the heart rate of the individuals using a frequency estimator of the skin color signals. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/458170 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/725 (20130101) A61B 5/02416 (20130101) Original (OR) Class A61B 5/7207 (20130101) A61B 5/7264 (20130101) A61B 2576/02 (20130101) Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 7/20 (20130101) G06T 7/90 (20170101) G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) G06T 2207/20076 (20130101) G06T 2207/20084 (20130101) G06T 2207/30088 (20130101) G06T 2207/30201 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386497 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanhe Zhao (Allston, Massachusetts); Yoonho Kim (Cambridge, Massachusetts) |
| ABSTRACT | Robotic devices and methods for performing minimally invasive procedures on the vascular system, particularly cerebrovascular and endovascular neurosurgical procedures, where a submillimeter-scale continuum robotic device is configured and adapted for active steering and navigation based on external magnetic actuation. The submillimeter-scale continuum robotic device includes an elongate body having an inner core and an outer shell, where the outer shell is fabricated of an elastomeric material having a plurality of ferromagnetic particles dispersed therein. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/458114 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/20 (20160201) A61B 34/71 (20160201) A61B 34/73 (20160201) Original (OR) Class A61B 2090/306 (20160201) Manipulators; Chambers Provided With Manipulation Devices B25J 9/1682 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386574 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hyunglae Lee (Phoenix, Arizona); Carly Thalman (Tempe, Arizona); Tiffany Hertzell (Cave Creek, Arizona); Marielle Debeurre (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyunglae Lee (Phoenix, Arizona); Carly Thalman (Tempe, Arizona); Tiffany Hertzell (Cave Creek, Arizona); Marielle Debeurre (Scottsdale, Arizona) |
| ABSTRACT | An ankle support assembly includes a body having a plurality of fabric layers. The body extends along a longitudinal axis. A sealed, inflatable chamber is supported by the body. A valve member is supported by the body and in fluid communication with the chamber. A plurality of retaining members are positioned relative to the chamber. The retaining members are spaced apart from each other. The retaining members are configured to limit expansion of the chamber in at least one direction. The retaining members are positioned relative to the chamber such that the body has a variable stiffness along the longitudinal axis when the chamber is inflated. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348149 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/012 (20130101) A61F 5/0111 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386848 | Ficht et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. Ficht (College Station, Texas); Allison Ficht (College Station, Texas); Renee Tsolis (Davis, California); Leslie Garry Adams (College Station, Texas); Angela M. Arenas-Gamboa (College Station, Texas) |
| ABSTRACT | Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to vaccines. In additional embodiments, the invention relates to formulations capable of releasing said vaccines at a controlled rate of release in vivo. In further embodiments, the invention relates to modified strains of the bacteria Brucella melitensis and Brucella abortus. In still further embodiments, the invention relates to compositions that do not induce clinical symptoms or splenomegaly in a subject receiving said compositions. |
| FILED | Monday, January 18, 2021 |
| APPL NO | 17/151488 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/098 (20130101) Original (OR) Class A61K 2039/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386907 | HARTGERINK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | Jeffrey HARTGERINK (Houston, Texas); David LEACH (Houston, Texas); Tania LOPEZ-SILVA (Houston, Texas) |
| ABSTRACT | Provided herein are peptide-based hydrogels, or neutral multidomain peptide hydrogel (NMDP), as well as uses thereof. The uses include encapsulating cells to induce quiescence for long-term storage and administering to a subject to induce collagen deposition and macrophage infiltration. The disclosed hydrogel is useful for the preservation of stem cells, including maintaining their quiescence and differentiation potential. |
| FILED | Wednesday, October 16, 2019 |
| APPL NO | 17/285767 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0231 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/22 (20130101) Original (OR) Class A61L 27/52 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386966 | HUISZOON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan HUISZOON (Silver Spring, Maryland); Sangwook CHU (San Jose, California); Reza GHODSSI (Potomac, Maryland) |
| ABSTRACT | Sensor electrodes are fabricated in situ within or on a surface of a medical device. For example, a catheter can have a lumen extending between first and second longitudinal ends of the catheter. A patterning mold can be inserted into the lumen via the first longitudinal end of the catheter such that first and second surface portions of the lumen are exposed from the patterning mold and remaining surface portions of the lumen are covered by and in contact with the patterning mold. A first electrode layer can be formed on the first and second surface portions exposed from the patterning mold using electroless deposition. After the forming, the patterning mold can be removed from the lumen. Additional electrode layers can be formed on the first electrode layer, for example, via electroplating. In some embodiments, the electrode layers can be used for detection of bacterial biofilm growth. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/347994 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/0012 (20130101) Original (OR) Class A61M 25/0017 (20130101) A61M 25/0045 (20130101) A61M 2025/0048 (20130101) A61M 2210/1078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387144 | Fan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Wyoming (Laramie, Wyoming) |
| ASSIGNEE(S) | University of Wyoming (Laramie, Wyoming); Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Maohong Fan (Ames, Iowa); Xiaowen Zhang (Laramie, Wyoming); Yangyan Gao (Laramie, Wyoming); Armistead G. Russell (Atlanta, Georgia); Xin He (Laramie, Wyoming) |
| ABSTRACT | A transformational energy efficient technology using ionic liquid (IL) to couple with monoethanolamine (MEA) for catalytic CO2 capture is disclosed. [EMmim+][NTF2−] based catalysts are rationally synthesized and used for CO2 capture with MEA. A catalytic CO2 capture mechanism is disclosed according to experimental and computational studies on the [EMmim+][NTF2−] for the reversible CO2 sorption and desorption. |
| FILED | Wednesday, February 17, 2021 |
| APPL NO | 17/177766 |
| CURRENT CPC | Separation B01D 53/8671 (20130101) Original (OR) Class B01D 53/8693 (20130101) B01D 2257/504 (20130101) B01D 2259/816 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/0278 (20130101) B01J 37/343 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388031 | Kumar |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| ASSIGNEE(S) | New Jersey Institute of Technology (Newark, New Jersey) |
| INVENTOR(S) | Dr. Vivek A. Kumar (Newark, New Jersey) |
| ABSTRACT | Disclosed is a new strategy, composition, and method for a self-assembling peptides (SAP) that will self-assemble atop COVID-19 for immune destruction and act as a functional COVID-19 opsonin. The designed self-assembling peptides bind and assemble atop SARS-CoV-2—providing a new mechanism of infection abrogation. One benefit is avoidance of side effects that other formulations or repurposed drugs contain. Other feature of this technology include: (a) (SAP) are composed of L-amino acids that are highly biocompatible sub-Q, IM and IV (no adverse reaction for 10% blood volume replacement with 1 w % peptide in mice or rats); (b) Highly targeted approach that binds to viral particles preventing side effects; (c) SAP are intrinsically biodegradable and endocytosed; (d) SAP bound COVID-19 may promote engulfment, clearance, and antigen presentation (for immunity development); and (e) targeting the spike protein with SAP may allow treatment of other coronaviruses. |
| FILED | Wednesday, June 16, 2021 |
| APPL NO | 17/348994 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class C07K 2319/735 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388430 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David Yu Zhang (Cambridge, Massachusetts); Peng Yin (Cambridge, Massachusetts) |
| ABSTRACT | Provided herein are primers and primer systems having improved specificity and kinetics over existing primers, and methods of use thereof. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/169145 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6832 (20130101) C12Q 1/6848 (20130101) C12Q 1/6853 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388437 | Doudna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Janice S. Chen (Berkeley, California); Lucas Benjamin Harrington (Berkeley, California); Enbo Ma (Moraga, California) |
| ABSTRACT | Provided are compositions and methods for detecting a target DNA (double stranded or single stranded) in a sample. In some embodiments, a subject method includes: (a) contacting the sample with: (i) a type V CRISPR/Cas effector protein (e.g., a Cas12 protein such as Cas12a, Cas12b, Cas12c, Cas12d, Cas12e); (ii) a guide RNA (comprising a region that binds to the type V CRISPR/Cas effector protein, and a guide sequence that hybridizes with the target DNA); and (iii) a detector DNA that is single stranded (i.e., a “single stranded detector DNA”) and does not hybridize with the guide sequence of the guide RNA; and (b) measuring a detectable signal produced by cleavage (by the type V CRISPR/Cas effector protein) of the single stranded detector DNA. Also provided are compositions and methods for cleaving single stranded DNAs (e.g., non-target ssDNAs), e.g., inside of a cell. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388321 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388526 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongping Zhao (Columbus, Ohio); A F M Anhar Uddin Bhuiyan (Columbus, Ohio); Zixuan Feng (Columbus, Ohio) |
| ABSTRACT | Disclosed herein methods of forming an Al—Ga containing film comprising: a) exposing a substrate comprising a β-Ga2O3, wherein the substrate has a (100) or (−201) orientation, to a vapor phase comprising an aluminum precursor and a gallium precursor; and b) forming a β-(AlxGa1-x)2O3 thin film by a chemical vapor deposition at predetermined conditions and wherein x is 0.01≤x≤0.7. Also disclosed herein are devices comprising the inventive films. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231382 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/165 (20130101) C30B 25/183 (20130101) C30B 25/186 (20130101) C30B 29/22 (20130101) Original (OR) Class C30B 29/68 (20130101) C30B 31/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389041 | GOLDFARBMUREN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rebound Technologies, Inc. (Commerce City, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RUSSELL GOLDFARBMUREN (Denver, Colorado); LUKE ERICKSON (Denver, Colorado) |
| ABSTRACT | Thermo-chemical recuperation systems, devices, and methods are provided in accordance with various embodiments. Embodiments may generally relate to the field of refrigeration and/or heat pumping. Within that field, some embodiments apply to the recuperation or recapturing of both thermal and chemical potential in a freeze point suppression cycle. Some embodiments include a method and/or system of thermo-chemical recuperation that includes creating a flow of ice and flowing a brine against the flow of the ice. Some embodiments manage the thermal and chemical potentials by mixing a dilute brine stream exiting an ice mixing vessel with an ice stream before it enters the ice mixing vessel. By controlling this mixing in a counter-flow or step-wise cross flow manner with sufficient steps, both the thermal and chemical potential of the dilute bine stream may be recuperated. |
| FILED | Sunday, June 20, 2021 |
| APPL NO | 17/352326 |
| CURRENT CPC | Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 5/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389183 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Qiushi Guo (New Haven, Connecticut); Cheng Li (New Haven, Connecticut); Fengnian Xia (Orange, Connecticut); Zhenqiang Ma (Madison, Wisconsin); Dong Liu (Madison, Wisconsin); Zhenyang Xia (Madison, Wisconsin) |
| ABSTRACT | In one aspect, the invention provides a nanobolometer cell including a base layer, a dielectric spacer layer above and adjacent to the base layer, an ultrathin silicon film above and adjacent to the spacer layer, and at least one plasmonic optical antenna resonator above and adjacent to the silicon film. |
| FILED | Friday, November 08, 2019 |
| APPL NO | 17/285644 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/513 (20130101) Original (OR) Class G01J 5/20 (20130101) G01J 5/022 (20130101) G01J 2005/0077 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/35 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1464 (20130101) H01L 27/14649 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389504 | Pyun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong-Chul Pyun (Tucson, Arizona); Robert A. Norwood (Tucson, Arizona); Abhinav Nishant (Tucson, Arizona); Laura Anderson (Tucson, Arizona); Tristan Kleine (Tucson, Arizona) |
| ABSTRACT | The present invention provides certain CHIP films and coatings, as well as the preparation and uses thereof. Chalcogenide hybrid organic/inorganic polymers or CHIPs may be suitable for use in antireflection coatings for use with infrared optics, for example as applied to lenses for infrared cameras. The coatings may be applied with spin coating and have a thickness related to the quarter wavelength of the desired infrared wavelengths. |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 17/282278 |
| CURRENT CPC | Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/006 (20130101) C09D 181/02 (20130101) C09D 185/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/111 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389601 | O'Toole et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew O'Toole (Pittsburgh, Pennsylvania); Mark Sheinin (Pittsburgh, Pennsylvania); Srinivasa Narasimhan (Pittsburgh, Pennsylvania) |
| ABSTRACT | A novel class of imaging systems that combines diffractive optics with 1D line sensing is disclosed. When light passes through a diffraction grating or prism, it disperses as a function of wavelength. This property is exploited to recover 2D and 3D positions from line images. A detailed image formation model and a learning-based algorithm for 2D position estimation are disclosed. The disclosure includes several extensions of the imaging system to improve the accuracy of the 2D position estimates and to expand the effective field-of-view. The invention is useful for fast passive imaging of sparse light sources, such as streetlamps, headlights at night and LED-based motion capture, and structured light 3D scanning with line illumination and line sensing. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178855 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/18 (20130101) G02B 27/0944 (20130101) G02B 27/4233 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389666 | Sreenivasan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sidlgata V. Sreenivasan (Austin, Texas); Shrawan Singhal (Austin, Texas); Ovadia Abed (Austin, Texas); Lawrence Dunn (Austin, Texas) |
| ABSTRACT | A method for fabricating patterns. An inverse optimization scheme is implemented to determine process parameters used to obtain a desired film thickness of a liquid resist formulation, where the liquid resist formulation includes a solvent and one or more non-solvent components. A substrate is covered with a substantially continuous film of the liquid resist formulation using one or more of the following techniques: dispensing discrete drops of a diluted monomer on the substrate using an inkjet and allowing the dispensed drops to spontaneously spread and merge, slot die coating and spin-coating. The liquid resist formulation is diluted in the solvent. The solvent is then substantially evaporated from the liquid resist formulation forming a film. A gap between a template and the substrate is then closed. The film is cured to polymerize the film and the substrate is separated from the template leaving the polymerized film on the substrate. |
| FILED | Thursday, August 03, 2017 |
| APPL NO | 16/322882 |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/24 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389783 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the Nevada System of Higher Education on Behalf of the University of Nevada (Las Vegas, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dongbin Kim (Las Vegas, Nevada); Paul Y. Oh (Las Vegas, Nevada) |
| ABSTRACT | A parallel manipulator with six degrees of freedom may include a base that attaches to a unmanned aerial vehicle and a movable gripper element that may be positioned below the UAV. The positioning of the gripper element my reduce impact of the center of gravity of the attached UAV. The gripper element may include a geometric shape that complements objects routinely used in high-throughput screening (HTS) laboratories, such as microplates. The parallel manipulator and gripper element may be used to quickly, safely, and securely move objects in HTS laboratories and/or the like. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348453 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 5/00 (20130101) B25J 9/003 (20130101) B25J 13/081 (20130101) B25J 13/089 (20130101) B25J 15/0052 (20130101) Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/128 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 1/22 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/106 (20190501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390188 | Mireshghallah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fatemehsadat Mireshghallah (La Jolla, California); Hadi Esmaeilzadeh (La Jolla, California) |
| ABSTRACT | Methods and systems that provide data privacy for implementing a neural network-based inference are described. A method includes injecting stochasticity into the data to produce perturbed data, wherein the injected stochasticity satisfies an ε-differential privacy criterion and transmitting the perturbed data to a neural network or to a partition of the neural network for inference. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/458165 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/60 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6228 (20130101) G06K 9/6298 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390236 | Jin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida); University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yier Jin (Gainesville, Florida); Shaojie Zhang (Orlando, Florida); James Geist (Oviedo, Florida); Travis Meade (Orlando, Florida); Jason Portillo (San Jose, California) |
| ABSTRACT | Embodiments herein provide for reverse engineering of integrated circuits (ICs) for design verification. In example embodiments, an apparatus receives a gate-level netlist for an integrated circuit (IC), generates a list of equivalence classes related to signals included in the gate-level netlist, determines control signals of the gate-level netlist based at least in part on the list of equivalence classes, determines a logic flow of a finite state transducer (FST) based at least in part on the control signals, and generates register transfer level (RTL) source code for the IC based on the FST. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343231 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/33 (20200101) Original (OR) Class G06F 30/327 (20200101) G06F 2115/08 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390380 | Gu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Gu (Evanston, Illinois); Zhengyu Chen (Evanston, Illinois) |
| ABSTRACT | Systems and methods for a low-cost mixed-signal time-domain accelerator for generative adversarial network (GAN) are provided. In one aspect, a system includes a memory and a training management unit (TMU) in communication with the memory. The TMU is configured to manage a training sequence. The system includes a time-domain multiplication-accumulation (TDMAC) unit in communication with the TMU, wherein the TDMAC unit is configured to perform time-domain multiplier operations and time-domain accumulator operations. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/347017 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Original (OR) Class G06N 3/088 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390383 | Gu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (EVANSTON, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Gu (Evanston, Illinois); Tianyu Jia (Evanston, Illinois) |
| ABSTRACT | Systems and methods for a unified reconfigurable neural central processing unit is provided. In one aspect, a neural central processing unit is in communication with a memory, wherein the neural central processing unit is configured to transition between a binary neural network accelerator mode and a central processing unit mode, wherein, in the binary neural network accelerator mode, the memory is configured as an image memory and weight memories, wherein, in the central processing unit mode, the memory is reconfigured, from the image memory and the weight memories, to a data cache. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/347233 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/0635 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390413 | Spanias et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Andreas Spanias (Tempe, Arizona); Sunil Srinivasa Manjanbail Rao (Tempe, Arizona); Gowtham Muniraju (Tempe, Arizona); Cihan Tepedelenlioglu (Chandler, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Andreas Spanias (Tempe, Arizona); Sunil Srinivasa Manjanbail Rao (Tempe, Arizona); Gowtham Muniraju (Tempe, Arizona); Cihan Tepedelenlioglu (Chandler, Arizona) |
| ABSTRACT | Dropout and pruned neural networks for fault classification in photovoltaic (PV) arrays are provided. Automatic detection of solar array faults leads to reduced maintenance costs and increased efficiencies. Embodiments described herein address the problem of fault detection, localization, and classification in utility-scale PV arrays. More specifically, neural networks are developed for fault classification, which have been trained using dropout regularizers. These neural networks are examined and assessed, then compared with other classification algorithms. In order to classify a wide variety of faults, a set of unique features are extracted from PV array measurements and used as inputs to a neural network. Example approaches to neural network pruning are described, illustrating trade-offs between model accuracy and complexity. This approach promises to improve the accuracy of fault classification and elevate the efficiency of PV arrays. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348410 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6268 (20130101) Computer Systems Based on Specific Computational Models G06N 3/082 (20130101) Original (OR) Class Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 50/10 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390444 | Puri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Shruti Puri (New Haven, Connecticut); Alexander Grimm (New Haven, Connecticut); Philippe Campagne-lbarcq (New Haven, Connecticut); Steven M. Girvin (Hamden, Connecticut); Michel Devoret (New Haven, Connecticut) |
| ABSTRACT | Techniques for performing quantum information processing using an asymmetric error channel are provided. According to some aspects, a quantum information processing includes a data qubit and an ancilla qubit, the ancilla qubit having an asymmetric error channel. The data qubit is coupled to the ancilla qubit. The ancilla qubit may be driven with a stabilizing microwave field to create the asymmetric error channel. |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/253460 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390772 | TAUBIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriel TAUBIN (Providence, Rhode Island); Fatih CALAKLI (Isparta, Turkey) |
| ABSTRACT | The invention is a computer implemented method, device, system, or article for reconstructing a surface of an object from a data set of the object comprising a plurality of partially oriented three dimensional points; each partially oriented three dimensional point comprising a point location and a point orientation vector; the point orientation vector being a fully specified point orientation vector, a partially specified orientation vector, or a missing point orientation vector. In particular, the invention comprises estimating the partially specified point orientation vectors and the missing point orientation vectors, resulting in a set of completely oriented three dimensional points; estimating a signed distance function from the set of completely oriented three dimensional points, and evaluating the smooth signed distance function on vertices of a volumetric mesh. The invention further comprises approximating the zero level set of the smooth signed distance function by a polygonal mesh using an isosurface algorithm to provide surface reconstruction of the object. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461492 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 17/00 (20130101) Original (OR) Class G06T 2210/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391485 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rui Q. Yang (Norman, Oklahoma); Wenxiang Huang (Norman, Oklahoma) |
| ABSTRACT | A PV device comprises a first mirror comprising a reflectance of higher than 50%; a second mirror interface; and an optical cavity positioned between the first mirror and the second mirror interface and comprising at least one IC stage. Each of the at least one IC stage comprises a conduction band; a valence band; a hole barrier comprising a first band gap; an absorption region coupled to the hole barrier, comprising a second band gap that is less than the first band gap, and configured to absorb photons; and an electron barrier coupled to the absorption region so that the absorption region is positioned between the hole barrier and the electron barrier. The electron barrier comprises a third band gap that is greater than the second band gap. The PV device is configured to operate at a forward bias voltage with a net photon absorption for generating an electric output. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344613 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/0816 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0547 (20141201) Original (OR) Class H01L 31/0735 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 10/30 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210391486 — Systems and Methods for Non-Epitaxial High Schottky-Barrier Heterojunction Solar Cells
| US 20210391486 | Jahelka et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Phillip R. Jahelka (Altadena, California); Rebecca D. Glaudell (Sierra Madre, California); Harry A. Atwater (South Pasadena, California) |
| ABSTRACT | Systems and methods of non-epitaxial high Schottky barriers heterojunction solar cells are described. The high Schottky barriers heterojunction solar cells are formed using non-epitaxial methods to reduce fabrication costs and improve scalability. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/346828 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/07 (20130101) Original (OR) Class H01L 31/0481 (20130101) H01L 31/0735 (20130101) H01L 31/03042 (20130101) H01L 31/022425 (20130101) H01L 31/035227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391591 | GOULET et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Marc-Antoni GOULET (Cambridge, Massachusetts); Roy G. GORDON (Cambridge, Massachusetts); Michael J. AZIZ (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides flow batteries including an anthraquinone and methods of discharging the batteries that reduce loss of capacity. The loss of capacity of anthraquinones may be mitigated by controlling the state of charge and/or oxidizing the negolyte. |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 17/281767 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) H01M 8/225 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391606 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Wang (Acton, Massachusetts); Eric Gratz (Worcester, Massachusetts); Qina Sa (Worcester, Massachusetts); Zhangfeng Zheng (Worcester, Massachusetts); Joseph Heelan (Woodstock, Connecticut); Kee-Chan Kim (Worcester, Massachusetts) |
| ABSTRACT | Cathode material from exhausted lithium ion batteries are dissolved in a solution for extracting the useful elements Co (cobalt), Ni (nickel), Al (Aluminum) and Mn (manganese) to produce active cathode materials for new batteries. The solution includes compounds of desirable materials such as cobalt, nickel, aluminum and manganese dissolved as compounds from the exhausted cathode material of spent cells. Depending on a desired proportion, or ratio, of the desired materials, raw materials are added to the solution to achieve the desired ratio of the commingled compounds for the recycled cathode material for new cells. The desired materials precipitate out of solution without extensive heating or separation of the desired materials into individual compounds or elements. The resulting active cathode material has the predetermined ratio for use in new cells, and avoids high heat typically required to separate the useful elements because the desired materials remain commingled in solution. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/412742 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 1/24 (20130101) C22B 7/007 (20130101) C22B 23/043 (20130101) C22B 23/0423 (20130101) C22B 23/0438 (20130101) C22B 26/22 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391726 | Avestruz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Al-Thaddeus Avestruz (Ann Arbor, Michigan); Alireza Ramyar (Ann Arbor, Michigan) |
| ABSTRACT | A device for DC-DC conversion includes a plurality of input ports to receive a set of DC voltage inputs, at least one DC voltage input being configured as a differential input, a plurality of input semiconductor switches, each input semiconductor switch being coupled to a respective input port of the plurality of input ports, an inductor coupled to each input semiconductor switch, a pair of output semiconductor switches coupled to the inductor, an output coupled to the inductor via the pair of output semiconductor switches, and a processor configured to generate input switch control signals for the plurality of input semiconductor switches to sequentially and selectively connect each DC voltage input to the inductor to charge the inductor and to generate an output switch control signal for the pair of output semiconductor switches to connect the inductor to the output to discharge the inductor via the output. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348692 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/381 (20130101) Original (OR) Class H02J 2300/26 (20200101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/08 (20130101) H02M 3/33569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391754 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Joshua R. Smith (Seattle, Washington); Benjamin Waters (Seattle, Washington) |
| ABSTRACT | A wireless power transfer system includes a transmitter configured to transmit power to a receiver, for example, through coupled resonators. The transmitter receives feedback from the receiver, and uses the feedback to control the power transmission, to control a parameter at the receiver, for example, a rectified voltage output by the receiver. The feedback to the transmitter may be provided, for example, by an out-of-band radio system between the transmitter and receiver, by a reflection coefficient at the transmitter, and/or by an encoded modulation of power in the receiver, for example, in an impedance matching module. The transmitter may control the transmitted power, for example, by controlling a transmitter signal generator voltage (VSIG), a transmitter gate driver voltage (VGD), a transmitter amplifier voltage (VPA), and/or an impedance setting in a transmitter impedance matching module. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461885 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/10 (20160201) Original (OR) Class H02J 50/12 (20160201) H02J 50/80 (20160201) Transmission H04B 5/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391809 | Reitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | C-Motive Technologies, Inc. (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Graham T. Reitz (Madison, Wisconsin); William D. Butrymowicz (Madison, Wisconsin); Justin K. Reed (Madison, Wisconsin); Daniel C. Ludois (Middleton, Wisconsin) |
| ABSTRACT | An electrostatic machine includes a drive electrode and a stator electrode. The drive electrode and the stator electrode are separated by a gap and form a capacitor. The drive electrode is configured to move with respect to the stator electrode. The electrostatic machine further includes a housing configured to enclose the drive electrode and the stator electrode. The stator electrode is fixed to the housing. The electrostatic machine also includes a dielectric fluid that fills a void defined by the housing, the drive electrode, and the stator electrode. The dielectric fluid includes an ester. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461087 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 69/00 (20130101) Electric Machines Not Otherwise Provided for H02N 1/002 (20130101) Original (OR) Class H02N 1/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391810 | Reitz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | C-Motive Technologies, Inc. (Madison, Wisconsin) |
| ASSIGNEE(S) | C-Motive Technologies, Inc. (Madison, Wisconsin) |
| INVENTOR(S) | Graham T. Reitz (Madison, Wisconsin); William D. Butrymowicz (Madison, Wisconsin); Baoyun GE (Madison, Wisconsin); Justin K. Reed (Madison, Wisconsin); Daniel C. Ludois (Madison, Wisconsin) |
| ABSTRACT | An electrostatic machine includes a drive electrode and a stator electrode. The drive electrode and the stator electrode are separated by a gap and form a capacitor. The drive electrode is configured to move with respect to the stator electrode. The electrostatic machine further includes a housing configured to enclose the drive electrode and the stator electrode. The stator electrode is fixed to the housing. The electrostatic machine also includes a dielectric fluid that fills a void defined by the housing, the drive electrode, and the stator electrode. The dielectric fluid includes a ketone, malonate, or an oxalate. |
| FILED | Thursday, September 12, 2019 |
| APPL NO | 17/293223 |
| CURRENT CPC | Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 3/445 (20130101) Electric Machines Not Otherwise Provided for H02N 1/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391943 | Djordjevic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Arizona, Tech Launch Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ivan Djordjevic (Tucson, Arizona); Houman Rastegarfar (Natick, Massachusetts); Mingwei Yang (Tucson, Arizona) |
| ABSTRACT | In one embodiment the present disclosure provides a controller to control uplink and downlink communications between at least one baseband unit (BBU) and at least one remote radio head (RRH) in a mobile fronthaul (MFH) network, the controller includes pseudorandom seed generating circuitry to initialize a pseudorandom seeding in the at least one BBU and at least one RRH and to cause the at least one BBU and at least one RRH to generate a pair of matching pseudorandom bit sequences (PRBS), the matching PRBS to enable the at least one BBU and at least one RRH to synchronize communications therebetween; wavelength and route assignment circuitry to select a wavelength and to select a route, through the MFH network, to enable the at least one BBU and at least one RRH to communicate using the selected wavelength and route; error code and modulation format selection circuitry to select an error correction code and a modulation format for communications between the at least one BBU and at least one RRH; transmission configuration circuitry to encode one or more parameters of a physical layer in the MFH network into the PRBS; and bit error rate monitoring circuitry to monitor a data stream between the at least one BBU and at least one RRH to determine if a bit error rate has changed for each frame of the data stream. |
| FILED | Saturday, June 12, 2021 |
| APPL NO | 17/346234 |
| CURRENT CPC | Transmission H04B 10/548 (20130101) H04B 10/572 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0041 (20130101) Original (OR) Class H04L 1/0058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210392529 | Spanias et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Andreas Spanias (Tempe, Arizona); Cihan Tepedelenlioglu (Tempe, Arizona); Gowtham Muniraju (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Andreas Spanias (Tempe, Arizona); Cihan Tepedelenlioglu (Tempe, Arizona); Gowtham Muniraju (Tempe, Arizona) |
| ABSTRACT | Various embodiments of a system and associated method for estimating a consensus driven distributed a spectral radius of a wireless sensor network are disclosed herein. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345652 |
| CURRENT CPC | Wireless Communication Networks H04W 24/08 (20130101) Original (OR) Class H04W 84/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210386029 | Hazlebeck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Global Algae Technology, LLC (Santee, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Hazlebeck (El Cajon, California); William Rickman (Lebanon, Tennessee); Paul Hazlebeck (El Cajon, California) |
| ABSTRACT | Embodiments of the disclosure provide systems and methods for supplying an algae cultivation fluid with nutrients (e.g., carbon dioxide and nitrogen) directly from the atmosphere. Supplying nutrients directly from the atmosphere reduces operational costs and environmental impacts, as well as provides greater flexibility in locating algae farms. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/346030 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/02 (20130101) A01G 33/00 (20130101) Original (OR) Class Apparatus for Enzymology or Microbiology; C12M 21/02 (20130101) C12M 23/18 (20130101) C12M 27/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386055 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| INVENTOR(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico) |
| ABSTRACT | Zr-based MOF NPs for cryopreservation of cells including, for example, red blood cells. |
| FILED | Wednesday, October 30, 2019 |
| APPL NO | 17/309152 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class A01N 1/0284 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) B01J 20/28007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386878 | O'Hara |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Matthew J. O'Hara (Richland, Washington) |
| ABSTRACT | Methods for purifying 89Zr are provided, 89Zr compositions are provided, isotope compositions are provided that can include: a radio isotope and a nanoparticle, and methods for radio labeling monoclonal antibodies are provided. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/460986 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/10 (20130101) Original (OR) Class Separation B01D 59/30 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/003 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 3/20 (20130101) Conversion of Chemical Elements; Radioactive Sources G21G 1/001 (20130101) G21G 4/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387405 | Sauers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Sauers (Aurora, Illinois); Robert D. Kephart (Pioneer, California) |
| ABSTRACT | A method and system for in situ cross-linking of polymers, Bitumen, and other materials to produce arbitrary functional or ornamental three-dimensional features using electron beams provided by mobile accelerators comprises defining a desired pattern for imparting on a target area, mapping the target area, defining at least one discrete voxel in the target area according to the desired pattern to be imparted on the target area, assigning an irradiation value to each of the at least one discrete voxels, and delivering a dose of irradiation to each of the at least one discrete voxels according to the assigned irradiation value. |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/407007 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/135 (20170801) Original (OR) Class B29C 64/264 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/24 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Construction Of, or Surfaces For, Roads, Sports Grounds, or the Like; Machines or Auxiliary Tools for Construction or Repair E01C 11/005 (20130101) E01C 23/14 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/06 (20130101) H01J 37/305 (20130101) H01J 37/1472 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387411 | WASHINGTON, II et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron L. WASHINGTON, II (Aiken, South Carolina); Donald W. BENZA (Aiken, South Carolina); Khai V. NGUYEN (Aiken, South Carolina) |
| ABSTRACT | Methods and systems for use in additive manufacturing are described. Methods include heating a precursor material in a mixing area upstream of a print head nozzle. An energy emission is delivered to the precursor material prior to extrusion at the nozzle. The energy emission encouraging reaction of components in the precursor material to form a solid product of the extrudate such as a polymer, a crosslinked polymeric matrix, and/or a particulate. Systems include a mixing area upstream of a nozzle and an energy source configured to deliver an emission into the mixing area at or near the nozzle outlet. |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 16/898945 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/209 (20170801) Original (OR) Class B29C 64/268 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387903 | LANGE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew LANGE (Livermore, California); Jay W. DAWSON (Livermore, California); Rebecca DYLLA-SPEARS (Dublin, California); Cody Wren MART (Livermore, California); Michael J. MESSERLY (Danville, California); Koroush SASAN (Pleasanton, California); Nick SCHENKEL (Livermore, California); Tayyab I. SURATWALA (Pleasanton, California) |
| ABSTRACT | The present disclosure relates to a method for forming a glass, ceramic or composite material. The method may involve initially forming a plurality of tubes and then performing a coating operation to coat the plurality of tubes with materials containing metal or metalloid elements, including inorganic compounds, organometallic compounds, or coordination complexes to form coated tubes. The method may further include performing at least one of a thermal operation or a thermochemical operation on the coated tubes to form a solid glass, ceramic, or composite structure with dimensions representing at least one of a rod or fiber. |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 16/899069 |
| CURRENT CPC | Manufacture, Shaping, or Supplementary Processes C03B 37/16 (20130101) C03B 37/02727 (20130101) Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 17/3636 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387987 | Redline et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erica Marie Redline (Albuquerque, New Mexico); Chad Staiger (Albuquerque, New Mexico); David R. Wheeler (Albuquerque, New Mexico); Leah Appelhans (Tijeras, New Mexico); Jeffrey C. Foster (Albuquerque, New Mexico) |
| ABSTRACT | Curatives and their resulting thermosets and other crosslinked polymers can reduce thermal expansion mismatch between an encapsulant and objects that are encapsulated. This can be accomplished by incorporating a negative CTE moiety into the thermoset resin or polymer backbone. The negative CTE moiety can be a thermal contractile unit that shrinks as a result of thermally induced conversion from a twist-boat to chair or cis/trans isomerization upon heating. Beyond CTE matching, other potential uses for these crosslinked polymers and thermosets include passive energy generation, energy absorption at high strain rates, mechanophores, actuators, and piezoelectric applications. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344717 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 211/60 (20130101) C07C 2602/12 (20170501) Heterocyclic Compounds C07D 321/12 (20130101) C07D 471/14 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/17 (20130101) C08K 5/053 (20130101) C08K 5/235 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388399 | Deng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Shuang Deng (Richland, Washington); Jon K. Magnuson (Richland, Washington); Joonhoon Kim (Berkeley, California); Kyle R. Pomraning (Richland, Washington); Ziyu Dai (Richland, Washington); Beth A. Hofstad (Richland, Washington) |
| ABSTRACT | Recombinant Aspergillus genetically modified to increase expression of g8846, renamed herein as aconitic acid exporter (aexA), are provided, which in some examples are also genetically inactivated for an endogenous cis-aconitic acid decarboxylase (cadA) gene. Such recombinant Aspergillus produce more aconitic acid as compared to native Aspergillus. Also provided are methods of using such recombinant Aspergillus to increase production of aconitic acid and other organic acids, such as citric acid, itaconic acid, and 3-hydroxypropionic acid (3-HP). |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/347109 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/145 (20210501) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/46 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/69 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388515 | Ding et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong Ding (Idaho Falls, Idaho); Hanping Ding (Idaho Falls, Idaho); Wei Wu (Idaho Falls, Idaho); Chao Jiang (Ammon, Idaho) |
| ABSTRACT | An electrochemical cell comprises a first electrode, a second electrode, and a proton-conducting membrane between the first electrode and the second electrode. The first electrode comprises a layered perovskite having the general formula: DAB2O5+δ, wherein D consists of two or more lanthanide elements; A consists of one or more of Sr and Ba; B consists of one or more of Co, Fe, Ni, Cu, Zn, Mn, Cr, and Nd; and δ is an oxygen deficit. The second electrode comprises a cermet material including at least one metal and at least one perovskite. Related structures, apparatuses, systems, and methods are also described. |
| FILED | Monday, October 28, 2019 |
| APPL NO | 17/309012 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/042 (20210101) C25B 9/23 (20210101) C25B 11/053 (20210101) Original (OR) Class C25B 11/091 (20210101) C25B 13/00 (20130101) C25B 15/023 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388520 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho); University of Idaho (Moscow, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junhua Jiang (Idaho Falls, Idaho); Haiyan Zhao (Idaho Falls, Idaho); Meng Shi (Idaho Falls, Idaho) |
| ABSTRACT | An electrochemical deposition system—for the electrochemical deposition of a metal-based material (e.g., aluminum or an aluminum alloy)—comprises an electrolyte solution, at least one working electrode, and at least one counter electrode. The electrolyte solution comprises at least one imidazolium-based tetrahalo-metallate compound (e.g., alkyl methylimidazolium tetrachloroaluminate(s)) and at least one metal-containing compound (e.g., AlCl3, AlBr3) of a metal of the metal-based material to be electrodeposited on the at least one working electrode. The working electrode is configured to be exposed to the electrolyte solution. The at least one counter electrode is in contact with the electrolyte solution. In some embodiments, the system is configured for additive manufacturing of the metal-based material being electrochemically deposited. Related methods are also disclosed. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/303945 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/665 (20130101) Original (OR) Class C25D 17/10 (20130101) C25D 21/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388697 | Su et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jiann-Cherng Su (Albuquerque, New Mexico); Stephen Buerger (Albuquerque, New Mexico); Anirban Mazumdar (Atlanta, Georgia); Adam Foris (Albuquerque, New Mexico) |
| ABSTRACT | A modular anti-rotation device for preventing rotation with respect to the central axis of a drilling tool in a borehole and for producing a notch in a borehole surface. The anti-rotation device includes an upper fixture portion and a lower fixture portion in axial alignment. The upper fixture portion and the lower fixture portion are connected by yoke assemblies. Each yoke assembly is connected to the fixture portion and fixture portion at one end, and forming an articulated joint of the upper yoke assembly and the lower yoke assembly at a distal end opposite the first end. A roller is connected at each joint, connecting the upper and lower yoke assemblies. The rollers engage vertically with a borehole surface, the rollers travelling axially, as a drill shaft penetrates into the borehole, the rollers simultaneously preventing radial movement of the anti-rotation device and prevent rotation with respect to the central axis of the borehole. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/412397 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 4/18 (20130101) E21B 17/02 (20130101) E21B 17/10 (20130101) E21B 17/1057 (20130101) E21B 17/1078 (20130101) E21B 43/106 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389061 | Nawaz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (OAK RIDGE, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kashif Nawaz (Knoxville, Tennessee) |
| ABSTRACT | A heat exchanger apparatus includes a tube having a wall with an inner surface and an outer surface. The tube is configured to receive heat exchange fluid at one end, and output, when heated through the wall, vapor of the heat exchange fluid at the opposing end. A first layer of thermally conductive porous material is disposed on the inner surface of the tube. Heating equipment, a heat exchanger, and a method of heating are also disclosed. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343277 |
| CURRENT CPC | Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/02 (20130101) F28F 13/003 (20130101) Original (OR) Class F28F 21/082 (20130101) F28F 21/084 (20130101) F28F 21/085 (20130101) F28F 21/089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389183 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Qiushi Guo (New Haven, Connecticut); Cheng Li (New Haven, Connecticut); Fengnian Xia (Orange, Connecticut); Zhenqiang Ma (Madison, Wisconsin); Dong Liu (Madison, Wisconsin); Zhenyang Xia (Madison, Wisconsin) |
| ABSTRACT | In one aspect, the invention provides a nanobolometer cell including a base layer, a dielectric spacer layer above and adjacent to the base layer, an ultrathin silicon film above and adjacent to the spacer layer, and at least one plasmonic optical antenna resonator above and adjacent to the silicon film. |
| FILED | Friday, November 08, 2019 |
| APPL NO | 17/285644 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/513 (20130101) Original (OR) Class G01J 5/20 (20130101) G01J 5/022 (20130101) G01J 2005/0077 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/35 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1464 (20130101) H01L 27/14649 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389210 | Jayakar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ZF PASSIVE SAFETY SYSTEMS US INC. (WASHINGON, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hylus Ranjit Raj Jayakar (Shelby Township, Michigan) |
| ABSTRACT | The present disclosure relates to a method for imaging an optical signal received by a graded index (GRIN) optical element to account for known variations in a graded index distribution of the GRIN optical element. The method may involve using a plurality of optical detector elements to receive optical rays received by the GRIN optical element at a plane, where the plane forms a part of the GRIN optical element or is downstream of the GRIN optical element relative to a direction of propagation of the optical rays. The optical rays are then traced to a plurality of additional specific locations on the plane based on the known variations in the graded index distribution of the GRIN optical element. A processor may be used to determine information on both an intensity and an angle of the received optical rays at each one of the plurality of specific locations on the plane of the GRIN optical element. |
| FILED | Wednesday, December 05, 2018 |
| APPL NO | 17/044353 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 11/0257 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389356 | Reiman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew P. Reiman (Richland, Washington); Jeffrey D. Taft (Washington, Pennsylvania); Casey C. Neubauer (West Richland, Washington) |
| ABSTRACT | This document describes systems and techniques for evaluating and improving distribution-grid observability. These systems and techniques allow engineers to quantify the observability of a distribution grid, which represents an ability to combine actual measurements and various types of computations (e.g., analytics, estimators, forecasters), from a system model. Distribution engineers can also identify islands of observability where operating parameters, including voltages, currents, and power flows, can be determined from available sensor readings. By exclusion, distribution engineers can similarly identify areas of the distribution grid with observability deficiencies that may require additional instrumentation to maintain proper operation. Distribution engineers, using an iterative or automated process, can determine the observability of the system model with new or relocated sensors to generate a sensor allocation plan. The sensor allocation plan can indicate the number and location of sensors to either maximize observability for a fixed sensor cost or minimize sensor cost for predetermined observability. |
| FILED | Friday, June 12, 2020 |
| APPL NO | 16/900727 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 22/10 (20130101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 13/00002 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389412 | Gonzalez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Eric G. Gonzalez (Richland, Washington); Michael S. Hughes (Richland, Washington); Anton S. Sinkov (Richland, Washington) |
| ABSTRACT | Firearm discharge location systems and methods are described. According to one aspect, a firearm discharge location system includes a plurality of microphones spaced from one another, timing circuitry configured to generate a plurality of asynchronous timing references, wherein data capture operations with respect to the microphones of a first pair are synchronized with one another using a first of the timing references and data capture operations with respect to the microphones of a second pair are synchronized with one another using a second of the timing references, and processing circuitry configured to use outputs of the first and second pairs of the microphones to identify a location of a firearm discharge. |
| FILED | Friday, May 15, 2020 |
| APPL NO | 17/285276 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/22 (20130101) Original (OR) Class G01S 2205/06 (20200501) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/08 (20130101) H04R 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389481 | Pegg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Scintilex, LLC (Alexandria, Virginia) |
| ASSIGNEE(S) | Scintilex, LLC (Alexandria, Virginia) |
| INVENTOR(S) | Ian Louis Pegg (Alexandria, Virginia); Tanja Horn (Lorton, Virginia) |
| ABSTRACT | Fiber reinforced aerogel composites, including a transparent composite material that contains an aerogel and fibers embedded into the aerogel and/or bonded to one or more surfaces of the aerogel, and composites that contain an aerogel tile and an assemblage of fibers embedded into the aerogel tile or bonded to the aerogel tile that are useful as Cherenkov radiators for the detection and identification of subatomic particles. Also, methods of making and using the composites. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336777 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 23/0006 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/76 (20130101) C04B 35/82 (20130101) C04B 38/0045 (20130101) C04B 2111/00991 (20130101) Measurement of Nuclear or X-radiation G01T 1/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210390998 | SeyedzadehDelcheh |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SeyedMohammad SeyedzadehDelcheh (Bellevue, Washington) |
| ABSTRACT | A method includes adding a set of one or more victim rows to a first probabilistic filter and to a second probabilistic filter, in response to a memory access request, identifying a candidate victim row adjacent to a memory address specified by a memory access request, identifying the candidate victim row as a victim row in the set of victim rows based on performing a lookup of the candidate victim row in a selected filter, where the selected filter includes one of the first probabilistic filter and the second probabilistic filter, in response to identifying the candidate row as the victim row, enabling a row hammering countermeasure, clearing the first probabilistic filter in each of a first set of time periods, and clearing the second probabilistic filter in each of a second set of time periods interleaved with the first set of time periods. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 16/902204 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/121 (20130101) G06F 12/0862 (20130101) G06F 2212/1032 (20130101) Static Stores G11C 11/4078 (20130101) Original (OR) Class G11C 11/4085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391591 | GOULET et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Marc-Antoni GOULET (Cambridge, Massachusetts); Roy G. GORDON (Cambridge, Massachusetts); Michael J. AZIZ (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides flow batteries including an anthraquinone and methods of discharging the batteries that reduce loss of capacity. The loss of capacity of anthraquinones may be mitigated by controlling the state of charge and/or oxidizing the negolyte. |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 17/281767 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) H01M 8/225 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391666 | MARTINEZ |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David K. MARTINEZ (Harlem, Georgia) |
| ABSTRACT | A high-voltage self-aligning push to mate electrical interconnect device is provided. The electrical interconnect device includes a housing with a mating end and a receiving end. The interconnect also includes an insulator bushing configured to be affixed to the receiving end of the housing. The interconnect also includes a center pin disposed within the housing. The center pin extends from the mating end of the housing to the receiving end of the housing. The interconnect also includes a connector socket disposed within the insulator bushing and which is in electrical communication with the center pin. The interconnect also includes an alignment sleeve including a chamfered mating funnel defining a void configured to accept and surround the housing and at least a portion of insulator bushing. |
| FILED | Wednesday, June 10, 2020 |
| APPL NO | 16/897735 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/53 (20130101) H01R 13/506 (20130101) Original (OR) Class H01R 13/6278 (20130101) Installation of Electric Cables or Lines, or of Combined Optical and Electric Cables or Lines H02G 15/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210391726 | Avestruz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Al-Thaddeus Avestruz (Ann Arbor, Michigan); Alireza Ramyar (Ann Arbor, Michigan) |
| ABSTRACT | A device for DC-DC conversion includes a plurality of input ports to receive a set of DC voltage inputs, at least one DC voltage input being configured as a differential input, a plurality of input semiconductor switches, each input semiconductor switch being coupled to a respective input port of the plurality of input ports, an inductor coupled to each input semiconductor switch, a pair of output semiconductor switches coupled to the inductor, an output coupled to the inductor via the pair of output semiconductor switches, and a processor configured to generate input switch control signals for the plurality of input semiconductor switches to sequentially and selectively connect each DC voltage input to the inductor to charge the inductor and to generate an output switch control signal for the pair of output semiconductor switches to connect the inductor to the output to discharge the inductor via the output. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348692 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/381 (20130101) Original (OR) Class H02J 2300/26 (20200101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/08 (20130101) H02M 3/33569 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210392050 | Taft et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey D. Taft (Washington, Pennsylvania); Sinan G. Aksoy (Seattle, Washington); Casey C. Neubauer (West Richland, Washington); Scott A. Upton (Richland, Washington) |
| ABSTRACT | This document describes systems and techniques for evaluating and improving distribution-grid data transportability. These systems and techniques allow engineers to quantify the data transportability of a communication system within or connected to a distribution grid, which represents an ability to transport in real-time telemetry from source locations (e.g., sensors in the distribution grid) to control mechanisms. Distribution engineers can use the sensor readings to perform grid analytics, control operating parameters, and operate protection systems. Distribution engineers can also use the transportability of the communication system to evaluate the observability of the distribution grid, which represents an ability to combine actual measurements and various types of computations (e.g., analytics, estimators, forecasters) from a system model. Distribution engineers can then generate a sensor allocation plan that indicates the number and location of sensors to maximize observability for a fixed sensor cost and/or minimize sensor cost for predetermined observability. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/339806 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/40 (20130101) G01R 31/086 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/12 (20130101) Original (OR) Class H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210386057 | Cope et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Accelerated Ag Technologies, LLC (Ankeny, Iowa) |
| ASSIGNEE(S) | Accelerated Ag Technologies, LLC (Ankeny, Iowa) |
| INVENTOR(S) | Jason Cope (Ankeny, Iowa); George Singletary (Ankeny, Iowa); Todd Krone (Des Moines, Iowa); Sara Katherine Etter (Bondurant, Iowa) |
| ABSTRACT | Described are methods of grain production with field conditioned pollen. A method of the present invention includes growing one or more designated female plants that include both female and male components, collecting fresh pollen from designated male plants from a different genetic background, and subjecting the fresh pollen to field conditions, which may regulate pollen moisture content. The field conditioning conditions may include a relative humidity ranging from about 50% to about 100%, a temperature ranging from about −10-10° C., and an air pressure ranging from about 15 kPa to about 150 kPa. These conditions may result in pollen having a moisture content of about 40% to about 58%. The one or more designated female plants are intentionally cross-pollinated with the field conditioned pollen and then grown to maturity such that the grain may be harvested therefrom. Also provided is a method of preventing undesirable pollination in grain production. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458944 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/02 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386095 | ERICKSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EVONIK OPERATIONS GMBH (Essen, Germany); BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska); DSM IP ASSETS B.V. (TE Heerlen, Netherlands) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Galen ERICKSON (Lincoln, Nebraska); Mitch NORMAN (Ashland, Nebraska); Christian RABE (Grossostheim, Germany); Andrea WATSON (Ceresco, Nebraska); Jonathan Wesley WILSON (Blacksburg, Virginia) |
| ABSTRACT | Condensed algal residue solubles turned out to be a beneficial feed ingredient for feeding animals, in particular for improving the growth performance of beef cattle. |
| FILED | Tuesday, October 08, 2019 |
| APPL NO | 17/284463 |
| CURRENT CPC | Fodder A23K 10/18 (20160501) A23K 10/38 (20160501) Original (OR) Class A23K 20/20 (20160501) A23K 20/147 (20160501) A23K 20/158 (20160501) A23K 20/174 (20160501) A23K 50/10 (20160501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386848 | Ficht et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. Ficht (College Station, Texas); Allison Ficht (College Station, Texas); Renee Tsolis (Davis, California); Leslie Garry Adams (College Station, Texas); Angela M. Arenas-Gamboa (College Station, Texas) |
| ABSTRACT | Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to vaccines. In additional embodiments, the invention relates to formulations capable of releasing said vaccines at a controlled rate of release in vivo. In further embodiments, the invention relates to modified strains of the bacteria Brucella melitensis and Brucella abortus. In still further embodiments, the invention relates to compositions that do not induce clinical symptoms or splenomegaly in a subject receiving said compositions. |
| FILED | Monday, January 18, 2021 |
| APPL NO | 17/151488 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/098 (20130101) Original (OR) Class A61K 2039/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387874 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PANI CLEAN, INC. (Coralville, Iowa); University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joun Lee (Coralville, Iowa); Syed Mubeen Jawahar Hussaini (Coralville, Iowa); David Cwiertny (Iowa City, Iowa); Abdulsattar Hashim Ghanim Al Saedi (Iowa City, Iowa); Timothy Alan Young (Santa Barbara, California) |
| ABSTRACT | Disclosed are systems and processes for the removal and conversion of pollutants in water. A system includes a set of electrodes with at least one electrode having an integrated catalyst material. The system is operatable in a first, electrodialysis mode in which one or more pollutants are separated from a feedwater stream, and a second electrolysis mode in which the separated pollutant(s) are catalytically converted into benign products by way of the catalyst material of the electrode. Electrodialysis and electrolysis are therefore carried out using the same unit. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345982 |
| CURRENT CPC | Separation B01D 61/46 (20130101) B01D 61/52 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/4676 (20130101) C02F 1/4693 (20130101) Original (OR) Class C02F 1/46109 (20130101) C02F 2001/46142 (20130101) C02F 2101/163 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388335 | THOLL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DOROTHEA THOLL (Blacksburg, Virginia); JASON LANCASTER (Blacksburg, Virginia) |
| ABSTRACT | Described herein are engineered polynucleotides and vectors capable of encoding one or more engineered southern green stink bug pheromone synthesis enzymes. Also described herein are engineered southern green stink bug pheromone synthesis enzymes. Also described herein are methods of making modified plants capable of expressing one or more southern green stink bug pheromone synthesis enzymes. |
| FILED | Saturday, September 28, 2019 |
| APPL NO | 17/291604 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Original (OR) Class C12N 15/8243 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210387750 | Fernandez |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Juan M. Fernandez (Norfolk, Virginia) |
| ABSTRACT | Various embodiments provide for Corrugated Rollable Tubular Boom (COROTUB) designs. Various embodiments provide a new thin-shell tubular mast design, specifically COROTUB designs, that have unique corrugation features enabled in part by shells only affixed to each other at two respective cross-sectional end web regions. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345440 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/22 (20130101) Original (OR) Class B64G 2001/224 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387753 | D'SOUZA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as Represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah Nicole D'SOUZA (Sacramento, California); Wendy Awele OKOLO (Mountain View, California); Benjamin William Look MARGOLIS (Oakland, California); Ben Edward NIKAIDO (Gilroy, California); Bryan Yount (Sunnyvale, California); Breanna Jermille JOHNSON (League City, Texas); Jeffrey BARTON (Ellicott City, Maryland); Kenneth Edward HIBBARD (Dundalk, Maryland) |
| ABSTRACT | A system for controlling an aerospace vehicle by exploiting the dihedral effect to control bank angle of the vehicle by modulating sideslip. The control system includes a closed feedback loop comprising an outer loop for producing a sideslip angle command to induce a roll moment through the dihedral effect to satisfy a bank angle command, and an inner loop for taking the sideslip angle command, and possibly an angle of attack command to produce control input for flightpath hardware controls. Flightpath control hardware include pairs of flaps arranged longitudinally along the leading and trailing edges of an aeroshell of an aerospace entry vehicle to control pitch for changing the angle of attack, and another pair of flaps arranged laterally to control yaw for changing the bank angle via the sideslip angle, and also moving mass along ribs to control pitch and yaw. Thrusters can be fired to induce roll. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348760 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/26 (20130101) B64G 1/62 (20130101) B64G 1/222 (20130101) B64G 1/244 (20190501) Original (OR) Class B64G 2700/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210387927 | Sherman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TERVES, LLC (Euclid, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J. Sherman (Mentor, Ohio); Brian Werry (Euclid, Ohio); Andrew Cortopassi (Euclid, Ohio); Eric Boyer (Euclid, Ohio) |
| ABSTRACT | A high density, generally recognized as safe, hybrid rocket motor is described, having a density-specific impulse similar to a solid rocket motor, with good performance approaching or equal to a liquid rocket motor. These high density hybrid motors resolve the packaging efficiency/effectiveness problems limiting the application of safe, low cost hybrid motor technology. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208467 |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 23/001 (20130101) C06B 23/006 (20130101) C06B 31/28 (20130101) Original (OR) Class Detonating or Priming Devices; Fuses; Chemical Lighters; Pyrophoric Compositions C06C 9/00 (20130101) Means for Generating Smoke or Mist; Gas-attack Compositions; Generation of Gas for Blasting or Propulsion C06D 5/10 (20130101) Jet-propulsion Plants F02K 9/24 (20130101) F02K 9/26 (20130101) F02K 9/70 (20130101) F02K 9/72 (20130101) F02K 9/425 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388761 | Voytovych et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dmytro Mykolayovych Voytovych (Rocky Hill, Connecticut); Om P. Sharma (South Windsor, Connecticut) |
| ABSTRACT | A blended wing aircraft including a blended wing fuselage and at least one embedded gas turbine engine in the fuselage. The gas turbine engine includes an inlet duct formed with a generally elliptical shape that includes a first set of ellipse sections along an upper portion of the inlet duct and a second set of ellipse sections along a lower portion of the inlet duct. The inlet duct includes a vertical centerline. The first set of ellipse sections at a throat of the inlet duct is larger in area than an area of an upstream most end of the second set of ellipse sections. The area of the second set of ellipse sections increases toward a downstream end of the inlet duct. A fan section has an axis of rotation that is spaced from the vertical centerline and is disposed within an inlet duct orifice. The inlet duct is upstream of the fan section. |
| FILED | Tuesday, January 12, 2021 |
| APPL NO | 17/147129 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 2039/105 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/00 (20130101) B64D 27/14 (20130101) B64D 33/02 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/02 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/04 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2250/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389377 | Bolotin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary S. Bolotin (Pasadena, California); Don J. Hunter (LaVerne, California); Malcolm L. Lias (Pasadena, California); Ben Cheng (Pasadena, California); John J. Waters (Pasadena, California); Sunant Katanyoutanant (Monterey Park, California) |
| ABSTRACT | Current sensing devices that are capable of surviving harsh ambient environment of ocean worlds, such as Jupiter and Saturn moons are disclosed. The described devices can meet 300 Krad radiation requirements and can survive at cold temperatures down to −184° C. Exemplary implementations of the constituent circuits of the devices are presented. A scheduling algorithm to perform various measurement by the disclosed current sensing devices is also described. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/339502 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/66 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 19/22 (20130101) G01R 31/34 (20130101) Original (OR) Class Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 29/60 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210386057 | Cope et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Accelerated Ag Technologies, LLC (Ankeny, Iowa) |
| ASSIGNEE(S) | Accelerated Ag Technologies, LLC (Ankeny, Iowa) |
| INVENTOR(S) | Jason Cope (Ankeny, Iowa); George Singletary (Ankeny, Iowa); Todd Krone (Des Moines, Iowa); Sara Katherine Etter (Bondurant, Iowa) |
| ABSTRACT | Described are methods of grain production with field conditioned pollen. A method of the present invention includes growing one or more designated female plants that include both female and male components, collecting fresh pollen from designated male plants from a different genetic background, and subjecting the fresh pollen to field conditions, which may regulate pollen moisture content. The field conditioning conditions may include a relative humidity ranging from about 50% to about 100%, a temperature ranging from about −10-10° C., and an air pressure ranging from about 15 kPa to about 150 kPa. These conditions may result in pollen having a moisture content of about 40% to about 58%. The one or more designated female plants are intentionally cross-pollinated with the field conditioned pollen and then grown to maturity such that the grain may be harvested therefrom. Also provided is a method of preventing undesirable pollination in grain production. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458944 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 1/02 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 3/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210386831 | JOSEPH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THERMALIN INC. (WABAN, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey I. JOSEPH (Penn Valley, Pennsylvania); Richard William BERENSON (Waban, Massachusetts); Bruce FRANK (Indianapolis, Indiana); Michael A. WEISS (Moreland Hills, Ohio); Thomas HATTIER (Cleveland Heights, Ohio); Gregory DUBÉ (Littleton, Massachusetts); Zhiqiang CHEN (Cleveland, Ohio) |
| ABSTRACT | The present invention provides rapid-acting insulin and insulin analogue formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogues, as well as other active agents. Methods of using the insulin and insulin analogue formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335141 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0021 (20130101) A61K 36/05 (20130101) A61K 36/23 (20130101) A61K 38/28 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/12 (20130101) A61K 47/20 (20130101) A61K 47/36 (20130101) A61K 47/183 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) A61M 5/1723 (20130101) A61M 25/02 (20130101) A61M 37/0092 (20130101) A61M 2025/0253 (20130101) A61M 2037/0007 (20130101) A61M 2205/35 (20130101) A61M 2205/50 (20130101) A61M 2205/055 (20130101) A61M 2205/502 (20130101) A61M 2230/201 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/327 (20130101) A61N 1/0448 (20130101) A61N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389481 | Pegg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Scintilex, LLC (Alexandria, Virginia) |
| ASSIGNEE(S) | Scintilex, LLC (Alexandria, Virginia) |
| INVENTOR(S) | Ian Louis Pegg (Alexandria, Virginia); Tanja Horn (Lorton, Virginia) |
| ABSTRACT | Fiber reinforced aerogel composites, including a transparent composite material that contains an aerogel and fibers embedded into the aerogel and/or bonded to one or more surfaces of the aerogel, and composites that contain an aerogel tile and an assemblage of fibers embedded into the aerogel tile or bonded to the aerogel tile that are useful as Cherenkov radiators for the detection and identification of subatomic particles. Also, methods of making and using the composites. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336777 |
| CURRENT CPC | Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster B28B 23/0006 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/76 (20130101) C04B 35/82 (20130101) C04B 38/0045 (20130101) C04B 2111/00991 (20130101) Measurement of Nuclear or X-radiation G01T 1/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210386709 | BAKER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JEREMY D. BAKER (Seattle, Washington); Rikki L. Uhrich (Seattle, Washington); Timothy J. Stovas (Seattle, Washington); Aleen D. Saxton (Seattle, Washington); Brian C. Kraemer (Seattle, Washington) |
| ABSTRACT | Described herein are compositions and methods for treating Alzheimer's disease, a tauopathy disorder or dementia. The compositions include mammalian suppressor of taupathy 2 (MSUT2) inhibitors. The methods include steps for identifying candidate compositions capable of inhibiting RNA binding proteins to poly(A) RNA and detecting RNA polyadenylation of poly(A) RNA. The methods include reducing accumulation of phosphorylated and aggregated human tau. |
| FILED | Thursday, May 13, 2021 |
| APPL NO | 17/319500 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/40 (20130101) A61K 31/41 (20130101) Original (OR) Class A61K 31/55 (20130101) A61K 31/192 (20130101) A61K 31/381 (20130101) A61K 31/445 (20130101) A61K 31/497 (20130101) A61K 31/4709 (20130101) A61K 31/4748 (20130101) A61K 31/4965 (20130101) A61K 31/4985 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210388080 | Rohrer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of The University of Colorado, A Body Corporate (Denver, Colorado); MUSC Foundation For Research Development (Charleston, South Carolina); United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Baerbel M. Rohrer (Charleston, South Carolina); V. Michael Holers (Denver, Colorado); Stephen Tomlinson (Charleston, South Carolina); Joshua M. Thurman (Greenwood Village, Colorado); Carl Atkinson (Mount Pleasant, South Carolina); Liudmila Kulik (Aurora, Colorado) |
| ABSTRACT | The present invention provides targeted delivery methods and constructs for treating inflammatory diseases and/or detecting in vivo tissue injuries in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The invention also provides methods of inhibiting complement-driven inflammation in the eye in an individual, comprising administering to the individual an antibody or a fragment thereor or compositions thereof, wherein the antibody or fragment thereof specifically binds to Annexin IV or phospholipid. Also provided are related methods of treating a complement-associated ocular disease or an ocular disease involving oxidative damage. Additionally, the invention provides methods of detecting complement-mediated injury in an eye tissue of an individual, comprising administering to the individual a construct or compositions thereof, wherein the construct comprises (a) an antibody or fragment thereof that specifically binds to Annexin IV or phospholipid; and (b) a detectable moiety. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228279 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/28 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20210389107 | VABNICK |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Federal Bureau of Investigation (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America as represented by the Federal Bureau of Investigation, Dept. of Justice (Washington, District of Columbia) |
| INVENTOR(S) | Ian B. VABNICK (Quantico, Virginia) |
| ABSTRACT | Provided are methods and related devices for disrupting an explosive device using a propellant driven disrupter (PDD) that propels a rounded projectile (RP) toward an explosive device. The RP travels along a linear trajectory and impacts the target, including a barrier portion of the explosive device. The impacting between the RP and barrier forms a composite projectile via a solid state weld between a portion of the barrier and the RP distal end, thereby minimizing or avoiding spall and fragment generation into the explosive device. The projectile traverses a penetration distance along the linear trajectory, or a defined-angle relative thereto, to disrupt the explosive device without unwanted explosive detonation. |
| FILED | Wednesday, December 30, 2020 |
| APPL NO | 17/138661 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 21/02 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 12/76 (20130101) F42B 12/745 (20130101) F42B 33/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20210391488 | HUANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ZHIHONG HUANG (Palo Alto, California); DI LIANG (Santa Barbara, California); YUAN YUAN (Palo Alto, California) |
| ABSTRACT | A device may include: a highly doped n+ Si region; an intrinsic silicon multiplication region disposed on at least a portion of the n+ Si region, the intrinsic silicon multiplication having a thickness of about 90-110 nm; a highly doped p− Si charge region disposed on at least part of the intrinsic silicon multiplication region, the p− Si charge region having a thickness of about 40-60 nm; and a p+ Ge absorption region disposed on at least a portion of the p− Si charge region; wherein the p+ Ge absorption region is doped across its entire thickness. The thickness of the n+ Si region may be about 100 nm and the thickness of the p− Si charge region may be about 50 nm. The p+ Ge absorption region may confine the electric field to the multiplication region and the charge region to achieve a temperature stability of 4.2 mV/° C. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 16/902135 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1446 (20130101) H01L 31/028 (20130101) H01L 31/105 (20130101) Original (OR) Class H01L 31/1804 (20130101) Transmission H04B 10/66 (20130101) Multiplex Communication H04J 14/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20210386672 | Vaughn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rapamycin Holdings, Inc. (San Antonio, Texas) |
| ASSIGNEE(S) | Rapamycin Holdings, Inc. (San Antonio, Texas) |
| INVENTOR(S) | Dana Vaughn (Seguin, Texas); Neal K. Vail (Castle Hills, Texas) |
| ABSTRACT | Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer, neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/391495 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 9/141 (20130101) A61K 9/146 (20130101) Original (OR) Class A61K 31/436 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210389325 | Norris et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Frontier Diagnostics, LLC (Smyrna, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy L. Norris (Smryna, Tennessee); Richard M. Caprioli (Brentwood, Tennessee); Jason B. Robbins (Nashville, Tennessee) |
| ABSTRACT | The present invention is directed to a mass spectrometry approach to identifying non-Spitzoid melanoma, and distinguishing non-Spitzoid nevi from non-Spitzoid malignant melanoma. |
| FILED | Monday, December 28, 2020 |
| APPL NO | 17/135488 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 33/5743 (20130101) Original (OR) Class G01N 33/6848 (20130101) G01N 2001/305 (20130101) G01N 2800/50 (20130101) G01N 2800/7028 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/164 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, December 16, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page