FedInvent™ Patent Applications
Application Details for Thursday, December 30, 2021
This page was updated on Friday, December 31, 2021 at 08:18 PM GMT
Department of Health and Human Services (HHS)
| US 20210401356 | Gluckman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce J. Gluckman (State College, Pennsylvania); Fatemeh Bahari (State College, Pennsylvania); Steven J. Schiff (State College, Pennsylvania) |
| ABSTRACT | Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/468398 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0205 (20130101) A61B 5/316 (20210101) A61B 5/352 (20210101) A61B 5/374 (20210101) A61B 5/4094 (20130101) Original (OR) Class A61B 5/7275 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401762 | CHENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Qiang CHENG (Dallas, Texas); Tuo WEI (Dallas, Texas); Daniel J. SIEGWART (Dallas, Texas) |
| ABSTRACT | The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473863 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 48/0033 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401777 | Wellman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | D. Andrew Wellman (Wayland, Massachusetts); Luigi Taranto-Montemurro (Chestnut Hill, Massachusetts) |
| ABSTRACT | Methods and compositions for the treatment of conditions associated with pharyngeal airway muscle collapse while the subject is in a non-fully conscious state, e.g., sleep apnea and snoring, comprising administration of a norepinephrine reuptake inhibitor (NRI) and a muscarinic receptor antagonist. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/471892 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/137 (20130101) Original (OR) Class A61K 31/216 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401805 | Nagarkatti et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Prakash Nagarkatti (Columbia, South Carolina); Kathryn Miranda (Columbia, South Carolina); Mitzi Nagarkatti (Columbia, South Carolina) |
| ABSTRACT | Described herein are functional CB1 signaling in immune cells is necessary to dampen HFD-induced microglia/macrophage-mediated neuroinflammation and reduce obesity, targeting immune CB1 receptors constitutes a novel therapeutic modality to lessen Diet-Induced Obesity, and circumvent adverse side effects of CB1 antagonist or neuronal CB1 agonist treatment. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242559 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/454 (20130101) A61K 31/4155 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401838 | Ablordeppey et al. |
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| FUNDED BY |
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| APPLICANT(S) | Florida A and M University (Tallahassee, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seth Y. Ablordeppey (Tallahassee, Florida); Xue Y. Zhu (Tallahassee, Florida) |
| ABSTRACT | A method of treating psychosis, and the underlying antipsychotic formulation. The method includes administering a therapeutically effective amount of synthetic agents that selectively recruit β-arrestin to D2 receptors and have little-to-no binding to culprit receptors associated with weight gain and Type II diabetes. The synthetic agents can include SYA16263 and SYA16264, and/or derivatives or analogs thereof. The 1-(pyridin-2-yl)piperazine moiety was found to play a significant role in recruiting β-arrestin to D2 receptors. In other embodiments, the current invention relates to synthetic agents that are selective of D4 receptors for treatment of psychosis and erectile dysfunction. The synthetic agents can include SYA27287 and/or derivatives or analogs thereof. In all embodiments, extrapyramidal side effects are eliminated or minimized. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/472882 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/506 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/18 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401849 | Rowlett |
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| FUNDED BY |
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| APPLICANT(S) | University of Mississippi Medical Center (Jackson, Mississippi) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James K. Rowlett (Ridgeland, Mississippi) |
| ABSTRACT | Disclosed are compositions and methods for treating benzodiazepine misuse and/or use disorder. A method of treating benzodiazepine misuse and/or use disorder includes administering to a subject in need thereof of an effective amount of a compound provides both partial modulator and antagonist effects at GABAA receptors. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361754 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/53 (20130101) Original (OR) Class A61K 31/501 (20130101) A61K 31/5025 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401856 | PAHAN |
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| FUNDED BY |
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| APPLICANT(S) | Rush University Medical Center (Chicago, Illinois) |
| ASSIGNEE(S) | Rush University Medical Center (Chicago, Illinois) |
| INVENTOR(S) | Kalipada PAHAN (Skokie, Illinois) |
| ABSTRACT | Provided herein are methods for delivering acetylsalicylic acid via nasal delivery for the treatment of neurodegenerative and lysosomal storage disorders, such as Alzheimer's disease and Batten disease. |
| FILED | Tuesday, November 05, 2019 |
| APPL NO | 17/290798 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0078 (20130101) A61K 31/616 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401858 | Heneine et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Walid Heneine (Atlanta, Georgia); Thomas M. Folks (Helotes, Texas); Robert Janssen (Atlanta, Georgia); Ronald A. Otten (Villa Rica, Georgia); Jose Gerardo Garcia Lerma (Decatur, Georgia) |
| ABSTRACT | A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host. A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170535 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 9/0053 (20130101) A61K 31/513 (20130101) A61K 31/675 (20130101) Original (OR) Class A61K 31/683 (20130101) A61K 31/7072 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401873 | LEE et al. |
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| FUNDED BY |
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| APPLICANT(S) | GLYCOMIRA THERAPEUTICS, INC. (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Won Yong LEE (Bountiful, Utah); Thomas P. Kennedy (Williamsburg, Virginia); Glenn D. Prestwich (Spokane, Washington) |
| ABSTRACT | Described herein are methods for reducing or maintaining the size of a tumor in a subject, where the method involves exposing the tumor to ionizing radiation and administering to the subject a modified hyaluronan or a pharmaceutically acceptable salt or ester. The use of the modified hyaluronan enhances or potentiates the effect of ionizing radiation used in cancer treatment. Additionally, the methods described herein prevent or reduces tumor regrowth in the subject after exposing the tumor to ionizing radiation and administration of the modified hyaluronan to the subject. |
| FILED | Monday, November 11, 2019 |
| APPL NO | 17/293103 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/737 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1001 (20130101) A61N 5/1077 (20130101) A61N 5/1084 (20130101) A61N 2005/109 (20130101) A61N 2005/1024 (20130101) A61N 2005/1087 (20130101) A61N 2005/1091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401874 | Golobish et al. |
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| FUNDED BY |
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| APPLICANT(S) | CytoSorbents Corporation (Monmouth Junction, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Golobish (Princeton, New Jersey); Maryann Gruda (Yardley, Pennsylvania); Tamaz Guliashvili (Philadelphia, Pennsylvania); Pamela O'Sullivan (Manalapan, New Jersey); Andrew Scheirer (Hoboken, New Jersey); Vi Dan (East Brunswick, New Jersey); Wei-Tai Young (Hillsborough, New Jersey); Vincent Capponi (Lawrenceville, New Jersey); Phillip Chan (Cherry Hill, New Jersey) |
| ABSTRACT | The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/341912 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/795 (20130101) Original (OR) Class A61K 47/20 (20130101) A61K 47/26 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3679 (20130101) A61M 5/165 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/264 (20130101) B01J 20/267 (20130101) B01J 20/28069 (20130101) B01J 39/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401883 | DUNHAM et al. |
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| FUNDED BY |
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| APPLICANT(S) | Hemanext Inc. (Lexington, Massachusetts) |
| ASSIGNEE(S) | Hemanext Inc. (Lexington, Massachusetts) |
| INVENTOR(S) | Andrew DUNHAM (Tower Lakes, Illinois); Tatsuro YOSHIDA (West Newton, Massachusetts); Samuel O. SOWEMIMO-COKER (Dix Hills, New York) |
| ABSTRACT | Methods for prevention and reversal of inflammation. |
| FILED | Thursday, November 14, 2019 |
| APPL NO | 17/292597 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/14 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401884 | Giannoukakis et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Nick Giannoukakis (Coraopolis, Pennsylvania); Massimo M. Trucco (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present invention relates to tolerogenic mammalian dendritic cells (iDCs) and methods for the production of tolerogenic DCs. In addition, the present invention provides methods for administration of tolerogenic dendritic cells as well as particles containing oligonucleotides to mammalian subjects. Enhanced tolerogenicity in a host can be useful for treating inflammatory and autoimmune related diseases, such as type 1 diabetes. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166985 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/15 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/064 (20130101) C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2501/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401896 | Marban et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
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| INVENTOR(S) | Eduardo Marban (Santa Monica, California); Romain Gallet (Paris, France) |
| ABSTRACT | Heart failure with preserved ejection fraction (HFpEF) is a disease condition characterized by heart failure (HF) signs and symptoms, but with normal or near normal left ventricular ejection fraction (LVEF) and is not responsive to standard therapy for treatment of HF. Described herein are compositions and methods related to use of cardiosphere derived cells (CDCs) and their exosomes to improve left ventricular structure, function and overall outcome. Administration of CDCs led to improved LV relaxation, lower LV end-diastolic pressure, decreased lung congestion and enhanced survival. Lower risk of arrhythmias in HFpEF was also observed following CDC administration. Improvement of diastolic dysfunction following administration of CDC-derived exosomes was observed, along with decreased mortality. In view of these salutary effects, CDCs and CDC-derived exosomes are beneficial in the treatment of HFpEF. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/469441 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/34 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401904 | BESNER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Research Institute at Nationwide Children's Hospital (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gail E. BESNER (Columbus, Ohio); Michael BAILEY (Columbus, Ohio); Steven GOODMAN (Columbus, Ohio) |
| ABSTRACT | Provided herein are methods and probiotic compositions for treating or preventing a disease or neurodevelopmental deficiency in a subject in need thereof using the compositions. Aspects and embodiments of this technology combine the health benefits of probiotic bacteria with prebiotic substances to help stimulate the exclusive growth of the probiotic species and, in one aspect, provide the bacteria in the form of a biofilm on a biocompatible microsphere. |
| FILED | Wednesday, June 03, 2020 |
| APPL NO | 16/961910 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1647 (20130101) A61K 35/742 (20130101) A61K 35/744 (20130101) A61K 35/745 (20130101) A61K 35/747 (20130101) Original (OR) Class A61K 47/42 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401936 | Kim |
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| FUNDED BY |
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| APPLICANT(S) | Wayne State University (Detroit, Michigan) |
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| INVENTOR(S) | Hyeong-Reh C. Kim (Bloomfield, Michigan) |
| ABSTRACT | Methods of treating a subject in need thereof are provided which include: administering a recombinant platelet derived growth factor D (PDGF D) composition to a mesenchymal stem cell of the subject and/or a progenitor derived therefrom, in vivo, or ex vivo, producing a treated mesenchymal stem cell of the subject and/or a progenitor derived therefrom, thereby stimulating the mesenchymal stem cell (MSC) and/or a progenitor derived therefrom. Cells expressing a recombinant PDGF D composition of the present are administered to the subject for in vivo delivery of the recombinant PDGF D composition according to aspects of the present disclosure. Methods and compositions are provided including recombinant PDGF D hemidimer (HD) including a full-length PDGF D polypeptide and a C-terminal growth factor domain of PDGF D, which lacks a CUB domain, promoting regulation of bone marrow MSC differentiation into osteogenic lineage cells. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362008 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 38/1858 (20130101) Original (OR) Class A61K 47/642 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/08 (20180101) Peptides C07K 14/49 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401937 | SOO et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | B. Chia SOO (Los Angeles, California); Kang TING (Los Angeles, California); Zhong ZHENG (Van Nuys, California); Chenshuang LI (Van Nuys, California) |
| ABSTRACT | Embodiments of the present invention provide a method treating cartilage arthritis in a subject in need thereof, which method comprising administering an effective amount of NELL-1 protein or peptide to the subject to ameliorate or treat at least an osteoinflammatory cartilage condition in the subject. The present invention also provides a composition and method therefor. |
| FILED | Thursday, October 31, 2019 |
| APPL NO | 17/289664 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1875 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401938 | Sawyer |
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| FUNDED BY |
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| APPLICANT(S) | Douglas B. Sawyer (Scarborough, Maine) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Douglas B. Sawyer (Scarborough, Maine) |
| ABSTRACT | Provided herein are methods for promoting differentiation of cardiac progenitor cells toward myocytes and suppressing the conversion of cardiac progenitor cells into fibroblasts and myofibroblasts cells in a subject determined to have cardiac progenitor cells in or around the heart, by administering a therapeutically effective amount of an NRG-1 peptide or functional variant or fragment thereof. The methods disclosed herein can be used to treat, prevent, or delay the progression of cardiac injury, for example heart failure or myocardial infarction. |
| FILED | Thursday, January 14, 2021 |
| APPL NO | 17/248217 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/706 (20130101) A61K 35/34 (20130101) A61K 38/1883 (20130101) Original (OR) Class Peptides C07K 14/4756 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5073 (20130101) G01N 33/6893 (20130101) G01N 2333/4756 (20130101) G01N 2800/32 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401955 | Iijima et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Norifumi Iijima (Osaka, Japan); Akiko Iwasaki (New Haven, Connecticut) |
| ABSTRACT | The present disclosure relates to compositions and methods for treating or preventing a disease or disorder of immunoprivileged tissue. It is described herein that an immunogenic composition which induces production of memory CD4 T cells allows for the access of a therapeutic antibody to the immunoprivileged tissue. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/467574 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 39/00 (20130101) A61K 39/0002 (20130101) A61K 39/02 (20130101) A61K 39/0005 (20130101) A61K 39/0007 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/395 (20130101) A61K 2035/122 (20130101) A61K 2039/5152 (20130101) A61K 2039/5156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401975 | BAKER, JR. et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James R. BAKER, JR. (Ann Arbor, Michigan); Anna U. BIELINSKA (Ann Arbor, Michigan); Douglas SMITH (Ann Arbor, Michigan); Paul E. MAKIDON (Ann Arbor, Michigan); Jessica J. O'KONEK (Ann Arbor, Michigan) |
| ABSTRACT | The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/368366 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/143 (20130101) A61K 9/1075 (20130101) A61K 39/35 (20130101) Original (OR) Class A61K 39/292 (20130101) A61K 47/22 (20130101) A61K 47/26 (20130101) A61K 47/44 (20130101) A61K 2039/57 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210401993 — TREATING INFLAMMATION USING LLP2A-BISPHOSPHONATE CONJUGATES AND MESENCHYMAL STEM CELLS
| US 20210401993 | Lane et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Nancy E. Lane (Hillsborough, California); Ruiwu Liu (Sacramento, California); Wei Yao (El Dorado Hills, California); Kit S. Lam (Davis, California) |
| ABSTRACT | The present invention provides methods of treating a subject having a primary inflammatory disease or disorder comprising administering to the subject a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, wherein the composition comprising the LLP2A-bisphosphonate conjugate enhances the delivery of mesenchymal stem cells to a site of inflammation. Methods of enhancing an anti-inflammatory or immunomodulatory property of mesenchymal stem cells, comprising administering to a subject in need thereof the mesenchymal stem cells and a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, are also provided. |
| FILED | Tuesday, January 05, 2021 |
| APPL NO | 17/142026 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/08 (20130101) A61K 9/0019 (20130101) A61K 31/663 (20130101) A61K 35/28 (20130101) A61K 47/64 (20170801) A61K 47/548 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402000 | Jiang et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Shaoyi Jiang (Seattle, Washington); Zhefan Yuan (Seattle, Washington); Liqian Niu (Seattle, Washington) |
| ABSTRACT | High-polymer-density bioconjugate compositions including multi-layer polymer bioconjugates, polymer backfilled bioconjugates, and multi-layer polymer backfilled bioconjugates, and methods for making the compositions. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 17/283731 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/593 (20170801) A61K 47/6425 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402036 | Xie |
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| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Zhongcong Xie (Andover, Massachusetts) |
| ABSTRACT | A device for selectively providing an odor-rich environment includes a housing and a cover. The housing includes a central cavity and a plurality of chambers configured to store a predefined fragrance therein and having a respective outlet formed on an outer wall of the housing. The cover includes an exterior surface having at least one vent formed on the exterior surface. The exterior surface includes an interior sidewall and an exterior sidewall forming an inner chamber that slidably engages the housing such that the cover is configured to move between an open position and a closed position. Responsive to the cover being in the open position, the at least one vent is generally adjacent to the outlet of at least one of the plurality of chambers of the housing. The odor-rich environment can assist in preventing and/or treating postoperative delirium (POD) postoperative cognitive dysfunction (POCD), and/or pain in a subject. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/467901 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 9/122 (20130101) A61L 9/125 (20130101) Original (OR) Class A61L 2209/11 (20130101) A61L 2209/12 (20130101) A61L 2209/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402053 | Bertassoni |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luiz E. Bertassoni (Portland, Oregon) |
| ABSTRACT | This disclosure relates to methods of mineralizing cell-laden matrices. Disclosed herein are cell-laden matrix compositions. Also disclosed herein are methods of selectively mineralizing a cell-laden matrix. Methods of culturing biomimetic bone tissue are disclosed herein. Also disclosed herein are kits containing compositions disclosed herein or portions thereof. |
| FILED | Wednesday, September 25, 2019 |
| APPL NO | 17/279437 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/04 (20130101) Original (OR) Class A61L 27/12 (20130101) A61L 27/24 (20130101) A61L 27/3834 (20130101) A61L 2430/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402061 | Reddy et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sashank Reddy (Baltimore, Maryland); Russell Martin (Baltimore, Maryland); Xiaowei Li (Towson, Maryland); Calvin Chang (Baltimore, Maryland); Kevin Colbert (Baltimore, Maryland); Hai-Quan Mao (Baltimore, Maryland) |
| ABSTRACT | A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel. |
| FILED | Thursday, May 09, 2019 |
| APPL NO | 17/054156 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/48 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 27/3808 (20130101) A61L 27/3834 (20130101) Original (OR) Class A61L 27/3895 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402063 | Alsberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eben Alsberg (Cleveland, Ohio); Oju Jeon (Cleveland, Ohio); Tae-Hee Kim (Cleveland, Ohio) |
| ABSTRACT | A composition includes a dual crosslinkable hydrogel that includes a plurality of polymer macromers, which are crosslinked with a first agent and a second agent different than the first agent, wherein the crosslinks formed using the second agent are reversible and repeatable to allow the mechanical properties of the hydrogel to be dynamically adjusted. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474985 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/26 (20130101) A61L 27/44 (20130101) Original (OR) Class A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 27/3608 (20130101) A61L 27/3834 (20130101) A61L 2300/236 (20130101) A61L 2300/252 (20130101) A61L 2300/412 (20130101) A61L 2300/414 (20130101) A61L 2400/16 (20130101) A61L 2430/40 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0084 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/002 (20130101) Derivatives of Natural Macromolecular Compounds C08H 1/06 (20130101) Compositions of Macromolecular Compounds C08L 5/04 (20130101) C08L 89/06 (20130101) C08L 2205/04 (20130101) C08L 2312/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402064 | Martin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell Martin (Baltimore, Maryland); Sashank Reddy (Baltimore, Maryland); Kevin Colbert (Baltimore, Maryland); Hai-Quan Mao (Baltimore, Maryland) |
| ABSTRACT | A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel. |
| FILED | Thursday, May 09, 2019 |
| APPL NO | 17/054161 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/48 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/3633 (20130101) A61L 2300/62 (20130101) A61L 2300/236 (20130101) A61L 2400/06 (20130101) A61L 2430/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402186 | Edgerton et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); University of Louisville Research Foundation, Inc. (Louisville, Kentucky); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor Reggie Edgerton (Los Angeles, California); Roland R. Roy (Playa Vista, California); Yury Gerasimenko (Los Angeles, California); Joel W. Burdick (Pasadena, California); Susan J. Harkema (Louisville, Kentucky); Jonathan Hodes (Louisville, Kentucky); Yu-Chong Tai (Pasadena, California); Mandheerej S. Nandra (Pasadena, California); Claudia A. Angeli (Lousiville, Kentucky); Thomas Anthony Desautels (Pasadena, California) |
| ABSTRACT | Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having a spinal cord injury, a brain injury, or a neurological neuromotor disease are described. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473406 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0237 (20130101) A61H 1/0274 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0551 (20130101) A61N 1/0553 (20130101) A61N 1/0556 (20130101) A61N 1/36003 (20130101) A61N 1/36103 (20130101) Original (OR) Class Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 21/00181 (20130101) A63B 69/0064 (20130101) Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps F04C 2270/0421 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402390 | Glezer et al. |
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| FUNDED BY |
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| APPLICANT(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eli N. Glezer (Del Mar, California); Sudeep Kumar (Gaithersburg, Maryland); Pankaj Oberoi (Rockville, Maryland); George Sigal (Rockville, Maryland); Michael Tsionsky (Derwood, Maryland) |
| ABSTRACT | The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 17/476880 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50853 (20130101) Original (OR) Class B01L 2300/021 (20130101) B01L 2300/043 (20130101) B01L 2300/0609 (20130101) B01L 2300/0829 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6816 (20130101) C12Q 1/6876 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6845 (20130101) G01N 33/54306 (20130101) G01N 33/54353 (20130101) G01N 2458/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402406 | Theberge et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (, None) |
| INVENTOR(S) | Ashleigh Brooks Theberge (Seattle, Washington); Erwin Stefan Peter Berthier (Seattle, Washington); Amanda Haack (Seattle, Washington); Dakota Kennedy (Seattle, Washington); Fang Yun Lim (Seattle, Washington) |
| ABSTRACT | A sample vessel includes a biological sample container and a sample stabilizer container. The biological sample container is configured to receive a biological sample and to store the biological sample. The sample stabilizer container is configured to contain a stabilizer associated with the biological sample. The sample stabilizer container is assembled from a stabilizer vial, an adaptor, and a fluid channel. The stabilizer vial is configured to store an amount of the stabilizer. The adaptor is configured to secure the biological sample container and the stabilizer vial such that the biological sample container and the stabilizer vial form the sample vessel. The fluid channel extends through the adaptor from the stabilizer vial to the biological sample container, the biological sample moving from the biological sample container into the stabilizer vial through the fluid channel. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361322 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/021 (20130101) B01L 3/523 (20130101) B01L 3/527 (20130101) B01L 3/567 (20130101) Original (OR) Class B01L 3/50273 (20130101) B01L 3/502738 (20130101) B01L 2200/16 (20130101) B01L 2200/141 (20130101) B01L 2300/042 (20130101) B01L 2300/049 (20130101) B01L 2400/0415 (20130101) B01L 2400/0622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 35/1002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402678 | You et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shangting You (La Jolla, California); Shaochen CHEN (San Diego, California) |
| ABSTRACT | A method and system for microscale 3D printing achieve high-fidelity fabrication through the control of the light exposure time. A single pulse of light is used to initiate polymerization of a pre-polymer solution to minimize scattering-induced resolution deterioration. The printed object is fabricated in a layer-by-layer construction where each layer is formed through exposure to a single light pulse. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/360891 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) Original (OR) Class B29C 64/232 (20170801) B29C 64/245 (20170801) B29C 64/273 (20170801) B29C 64/286 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403416 | Bergeson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan E. Bergeson (Lubbock, Texas); Ted W. Reid (Lubbock, Texas); Mayank Shashtri (Lubbock, Texas); Peter Syapin (Camarillo, California); Phat Tran (Lubbock, Texas) |
| ABSTRACT | The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: identifying a subject in need of treatment for at least one of AUD, SUD, pain, or a proinflammatory disorder; and providing the subject with an effective amount of a modified minocycline to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that has reduced, or no, antimicrobial activity, wherein the modified tetracycline has a formula, e.g., or the modified doxycycline, minocycline, and tigecycline and their tautomerized structures, where the R-groups shown in the minocycline example above could be different combination of halogen, acetyl ester, methyl ester, and diacetal. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 17/251469 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4848 (20130101) Acyclic or Carbocyclic Compounds C07C 237/26 (20130101) Original (OR) Class C07C 2603/46 (20170501) Heterocyclic Compounds C07D 317/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403444 | PLEMPER et al. |
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| FUNDED BY |
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| APPLICANT(S) | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard K. PLEMPER (Decatur, Georgia); Eddy LEE (Alpharetta, Georgia); John VERNACHIO (Alpharetta, Georgia); Elyse BOURQUE (L'etang-du Nord, Canada) |
| ABSTRACT | Disclosed herein are compounds and compositions for treating or inhibiting RSV and related members of the pneumovirus and paramyxovirus families such as human metapneumovirus, mumps virus, human parainfluenzaviruses, and Nipah and hendra virus, and methods of treatment or prevention thereof. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370586 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/542 (20130101) A61K 31/5415 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Heterocyclic Compounds C07D 279/16 (20130101) Original (OR) Class C07D 417/06 (20130101) C07D 417/12 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/18511 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403445 | Coates et al. |
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| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey W. Coates (Lansing, New York); Aran K. Hubbell (Ithaca, New York) |
| ABSTRACT | Provided are methods of carbonylating cyclic substrates to produce carbonylated cyclic products. The cyclic substrates may be 2, 2-di substituted epoxides and the cyclic products may be β,β-di substituted lactones. The method may be carried out by forming and pressurizing a reaction mixture of the cyclic substrate, a solvent, carbon monoxide, and a [LA+][CO(CO)4−] catalyst, where [LA+] is a Lewis acid capable of coordinating to the cyclic substrate. The method may proceed with a regio selectivity of 90:10 or greater. The resulting carbonylated cyclic products may be converted to ketone aldol products that retain the stereochemistry and enantiomeric ratio of the carbonylated cyclic products. |
| FILED | Monday, November 18, 2019 |
| APPL NO | 17/293424 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/183 (20130101) B01J 31/2217 (20130101) B01J 2231/321 (20130101) B01J 2531/31 (20130101) Acyclic or Carbocyclic Compounds C07C 67/37 (20130101) Heterocyclic Compounds C07D 305/12 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/069 (20130101) C07F 11/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403499 | Pemberton et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| INVENTOR(S) | Jeanne E. Pemberton (Tucson, Arizona); Robin L. Polt (Tucson, Arizona); Raina M. Maier (Tucson, Arizona); Ricardo Palos Pacheco (Tucson, Arizona) |
| ABSTRACT | The present invention provides carbohydrate-based surfactants and methods for producing the same. Methods for producing carbohydrate-based surfactants include using a glycosylation promoter to link a carbohydrate or its derivative to a hydrophobic compound. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473999 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 3/003 (20130101) C07F 9/94 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 15/04 (20130101) C07H 15/06 (20130101) C07H 15/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403510 | Samulski et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Jude Samulski (Chapel Hill, North Carolina); Jayme Warischalk (Chapel Hill, North Carolina) |
| ABSTRACT | This invention relates to modified parvovirus capsid proteins with enhanced transduction efficiency, viral vectors comprising the same, and methods of using the same for delivery of nucleic acids to a cell or a subject. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407716 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Peptides C07K 14/015 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403513 | Truong et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David M. Truong (New York, New York); Jef D. Boeke (New York, New York) |
| ABSTRACT | Yeast having modified chromosomes are provided. The chromosomes are modified such that at least one of yeast histones H3, H4, H2A or H2B are fully or partially replaced by their human histone counterparts H3, H4, H2A or H2B, respectively. Histone amino acid substitutions are included. Cell fusions with the yeast having the modified chromosomes and non-yeast cells are provided. Methods for screening test agents using the yeast are also provided. Yeast with a mutated yeast DAD1 gene, the mutated DAD1 gene encoding an E50D mutation in yeast DAD1 protein, are provided, and provide a useful genetic background for making the yeast with partially or fully replaced histone(s). |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/368216 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) C07K 14/395 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403521 | BORKAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Boston Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Boston Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Steven C. BORKAN (Medfield, Massachusetts); Zhiyong WANG (Cambridge, Massachusetts) |
| ABSTRACT | One aspect of the technology relates to methods, assays and kits to identify ischemia and ischemic injury, including kidney injury, and are useful in determining efficacy of cancer treatments. In particular, differential phosphorylation of the nucleophosmin (NPM) polypeptide is an early marker of ischemic injuries such as kidney injury, AKI and ischemic renal cell injury. Another aspect of the technology relates to compositions and methods for the treatment of ischemia and kidney injury, including NPM inhibitory agents, including, but not limited to NPM inhibitory peptides for the treatment of ischemia and kidney injury. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/459680 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 13/12 (20180101) Peptides C07K 14/47 (20130101) C07K 14/4703 (20130101) Original (OR) Class C07K 2319/09 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/6875 (20130101) G01N 33/54306 (20130101) G01N 2440/14 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403523 | Selsted et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael E. Selsted (Pasadena, California); Dat Q. Tran (Alhambra, California); Justin B. Schaal (Orange, California); Virginia Basso (West Covina, California) |
| ABSTRACT | Peptide analogs of a θ-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These θ-defensin analogs are protective at concentrations where naturally occurring θ-defensins have no apparent effect, and include a core set of structural and sequence features not found in native θ-defensins. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358828 |
| CURRENT CPC | Peptides C07K 14/4723 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403526 | Dong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xinzhong Dong (Clarksville, Maryland); Hao-jui Weng (Taipei City, Taiwan) |
| ABSTRACT | The present invention features compositions of Tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/368065 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) A61K 48/00 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403538 | CROWE, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee); Pavlo GILCHUK (Nashville, Tennessee); Alexander BUKREYEV (Galveston, Texas) |
| ABSTRACT | The present disclosure is directed to human antibodies binding to and neutralizing ebolavirus and methods for use thereof. A further embodiment involves a monoclonal antibody, wherein the antibody or antibody fragment is characterized by clone-paired heavy and light chain CDR sequences. In yet another embodiment, there is provided a hybridoma or engineered cell encoding an antibody or antibody fragment. An additional embodiment comprises a vaccine formulation comprising one or more antibodies or antibody fragments characterized by clone-paired heavy and light chain CDR sequences. In still a further embodiment, there is provided a method of protecting the health of a placenta and/or fetus of a pregnant a subject infected with or at risk of infection with ebolavirus comprising delivering to said subject the antibody or antibody fragment. |
| FILED | Thursday, July 11, 2019 |
| APPL NO | 17/259263 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403549 | SESSA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William C. SESSA (Madison, Connecticut); Jan KRAEHLING (Düsseldorf, Germany) |
| ABSTRACT | In one aspect, the invention comprises a fusion construct comprising ALKI extracellular domain and a stability enhancing domain. In another aspect, the invention comprises an antibody that interferes with or blocks the ALKI extracellular domain binding to LDL, but does not interfere with or block the ALKI extracellular domain binding to BMP9/10. In yet another aspect, the invention comprises methods of reducing rates of LDL uptake in the endothelial cells of a patient in need thereof by administering the fusion construct or monoclonal antibodies described herein to the patient. |
| FILED | Thursday, May 17, 2018 |
| APPL NO | 16/614225 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Peptides C07K 14/705 (20130101) C07K 16/247 (20130101) Original (OR) Class C07K 2317/32 (20130101) C07K 2317/76 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403578 | Garcia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenan Christopher Garcia (Menlo Park, California); David Baker (Seattle, Washington); Claudia Yvonne Janda (Palo Alto, California); Luke Dang (Carnation, Washington); James Daniel Moody (Bozeman, Montana) |
| ABSTRACT | Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/469661 |
| CURRENT CPC | Peptides C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/31 (20130101) C07K 2317/75 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/569 (20130101) C07K 2317/622 (20130101) C07K 2318/20 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403597 | SPRIGGS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York); Eureka Therapeutics, Inc. (Emeryville, California) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York); Eureka Therapeutics, Inc. (Emeryville, California) |
| INVENTOR(S) | David SPRIGGS (New York, New York); Javier MORALES (Emeryville, California); Yoko NAKANO (Emeryville, California); Hong LIU (Emeryville, California) |
| ABSTRACT | Provided herein are compositions, methods, and uses involving anti-Mucin-16 (MUC16) agents that immunospecifically bind an epitope of Mucin-16 (MUC16). Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer and diseases associated with positive MUC16 expression. |
| FILED | Thursday, November 14, 2019 |
| APPL NO | 17/292749 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/3092 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/31 (20130101) C07K 2317/34 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403644 | Xu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Peisheng Xu (Chapin, South Carolina) |
| ABSTRACT | Described herein are systems and methods for the degradation of endogenous protein with the help of a nanocarrier, which has the advantage of easy scale-up and feasibility for in vivo application. |
| FILED | Wednesday, April 28, 2021 |
| APPL NO | 17/242647 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 47/64 (20170801) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/10 (20130101) C08G 69/26 (20130101) C08G 69/48 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403853 | LUDLAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cairn Biosciences, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mary J. C. LUDLAM (San Francisco, California); David WARTMANN (Berkeley, California); Ciara GALLAGHER (Redwood City, California) |
| ABSTRACT | A method for dynamic evolution and/or adaptation and monitoring of characteristics in living cells is provided, wherein the method may be performed at a microfluidic-enabled cell-culture device comprising pneumatic layer for directing flow of fluid to a plurality of individually addressable wells, and one or more sensors configured to detect data regarding environments inside one or more of the plurality of wells. The method may involve culturing a population of cells in a first well of the plurality of wells, perturbing one or more characteristics of an environment in the first well following the culturing of the population of cells, monitoring one or more characteristics of the population of cells in the first well, and removing all or part of the evolved/adapted population of cells from the first well. |
| FILED | Thursday, November 14, 2019 |
| APPL NO | 17/293407 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) C12M 23/20 (20130101) C12M 29/00 (20130101) C12M 35/04 (20130101) C12M 35/08 (20130101) C12M 41/36 (20130101) Original (OR) Class C12M 41/46 (20130101) C12M 47/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 2500/00 (20130101) C12N 2527/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6452 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403861 | ZHANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng ZHANG (Cambridge, Massachusetts); Le Cong (Cambridge, Massachusetts) |
| ABSTRACT | The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (DNA) binding polypeptide having a N-terminal capping region, a DNA binding domain comprising at least five or more Transcription activator-like effector (TALE) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a C-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the DNA of the genomic locus. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 17/477135 |
| CURRENT CPC | Peptides C07K 14/03 (20130101) C07K 14/195 (20130101) C07K 14/4703 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/06 (20130101) Original (OR) Class C12N 5/0686 (20130101) C12N 9/22 (20130101) C12N 9/1241 (20130101) C12N 15/635 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210403863 — MICROGLIA DERIVED FROM PLURIPOTENT STEM CELLS AND METHODS OF MAKING AND USING THE SAME
| US 20210403863 | Douvaras et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | New York Stem Cell Foundation, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Panagiotis Douvaras (New York, New York); Scott Noggle (New Rochelle, New York); Stephen Chang (Poway, California); Valentina Fossati (New York, New York) |
| ABSTRACT | The present invention provides methods and compositions for the generation of microglial progenitor cells and microglial cells from pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells. The present invention also provides cells produced using such methods, and both methods of treatment and methods of drug screening that use such cells. Also provided are various tissue culture media, tissue culture media supplements, and kits useful for the generation of human microglial progenitor cells and human microglial cells. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473257 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0618 (20130101) C12N 5/0622 (20130101) Original (OR) Class C12N 2500/90 (20130101) C12N 2501/22 (20130101) C12N 2501/155 (20130101) C12N 2501/2334 (20130101) C12N 2506/45 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403870 | Broeckel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Medical College of Wisconsin, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ulrich Broeckel (Wauwatosa, Wisconsin); Praful Aggarwal (Wauwatosa, Wisconsin); Milica Radisci (Toronto, Canada); Yimu Zhao (Toronto, Canada) |
| ABSTRACT | A method for generating an in vitro cardiac tissue model. The method includes steps of: forming an elongated tissue by disposing a plurality of cardiomyocytes within a culture plate; culturing the tissue such that each end of the elongated tissue contacts one of a pair of attachment wires adhered to the culture plate; and electrically stimulating the elongated tissue in culture. |
| FILED | Monday, November 25, 2019 |
| APPL NO | 17/297075 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) Original (OR) Class C12N 2529/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403878 | Lin et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tongxiang Lin (San Diego, California); Sheng Ding (Orinda, California) |
| ABSTRACT | The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/320676 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0696 (20130101) Original (OR) Class C12N 2501/065 (20130101) C12N 2501/602 (20130101) C12N 2501/603 (20130101) C12N 2501/604 (20130101) C12N 2501/606 (20130101) C12N 2501/727 (20130101) C12N 2501/999 (20130101) C12N 2506/28 (20130101) C12N 2506/094 (20130101) C12N 2506/1307 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403879 | LIVENGOOD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TAKEDA VACCINES, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jill A LIVENGOOD (Cambridge, Morocco); Holli GIEBLER (Cambridge, Massachusetts); Hansi DEAN (Cambridge, Massachusetts); Tatsuki SATOU (Hikari-shi, Yamaguchi, Japan); Raman RAO (Singapore, Singapore); Jackie MARKS (Cambridge, Massachusetts); Mark LYONS (Cambridge, Massachusetts); Asae SHINTANI (Hikari-shi, Yamaguchi, Japan); James GIFFORD (Cambridge, Massachusetts); Nao OGASAWARA (Osaka-shi, Osaka, Japan); Masafumi MISAKI (Hikari-shi, Yamaguchi, Japan); Satoshi ADACHI (Hikari-shi, Yamaguchi, Japan) |
| ABSTRACT | The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation and to a method for determining the residual formaldehyde content in a pharmaceutical composition comprising an inactivated virus. |
| FILED | Friday, November 30, 2018 |
| APPL NO | 16/768550 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/5252 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403885 | Balagopalan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Lakshmi Balagopalan (Bethesda, Maryland); Chang Kyun Yi (Germantown, Maryland); Katherine Marie McIntire (Sandy, Utah); Lawrence Elliot Samelson (Bethesda, Maryland) |
| ABSTRACT | Chimeric polypeptides including (a) an extracellular targeting domain; (b) a transmembrane domain; (c) an intracellular linker for activation of T cells (LAT) domain or SLP-76 domain; and (d) an intracellular ZAP70 domain, wherein (a)-(d) are in N-terminal to C-terminal order are provided. Chimeric polypeptides including (a) an extracellular targeting domain; (b) a transmembrane domain; and (c) a ZAP70 domain, wherein (a)-(c) are in N-terminal to C-terminal order are also provided. In some embodiments, the chimeric polypeptide further includes a hinge domain, a signal sequence domain, and/or an intracellular signaling domain. Nucleic acid molecules encoding the chimeric polypeptides and expression vectors including the nucleic acids are also provided. Isolated cells (such as T cells or natural killer cells) expressing the chimeric polypeptides and methods of treating a subject with cancer with the isolated cells are provided. |
| FILED | Wednesday, September 15, 2021 |
| APPL NO | 17/475810 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2039/5156 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Peptides C07K 14/535 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/2803 (20130101) C07K 16/2812 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Original (OR) Class Enzymes C12Y 207/10002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403910 | McNally |
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| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth McNally (Oak Park, Illinois) |
| ABSTRACT | Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or treating dystrophic diseases such as Limb-Girdle Muscular Dystrophy. |
| FILED | Thursday, September 09, 2021 |
| APPL NO | 17/470892 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403920 | Garcia-Blanco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mariano A. Garcia-Blanco (Galveston, Texas); Gaddiel Galarza-Munoz (Galveston, Texas); Shelton S. Bradrick (Galveston, Texas) |
| ABSTRACT | The present invention includes compositions and methods for treating an autoimmune disorder or a cancer in a subject in need thereof, the method comprising: administering an effective amount of a composition comprising an oligonucleotide that specifically binds a complementary sequence of the Interleukin-7 receptor (IL7R) pre-mRNA that influences splicing of exon 6, wherein the SM-ASO increases or decreases inclusion of exon 6 in IL7R pre-mRNAs and respectively decreases or increases expression of the soluble isoform of IL7R (sIL7R). In certain embodiments, the oligonucleotide is an antisense oligonucleotide (ASO), or a splice-modulating antisense oligonucleotide (SM-ASO). |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/411265 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2320/31 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403944 | Anderson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts) |
| ABSTRACT | Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/468100 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403946 | Deverman et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Benjamin E. Deverman (Cambridge, Massachusetts); FatmaElzahraa Eid (Cambridge, Massachusetts); Ken Y. Chan (Cambridge, Massachusetts) |
| ABSTRACT | Techniques for identifying production-fit amino acid sequence libraries are disclosed. The techniques may include accessing a statistical model relating an input amino acid sequence to production fitness of a protein having the input amino acid sequence, obtaining production fitness information for production-fit variant amino acid sequences, and generating an amino acid sequence library having amino acid sequences with predicted production fitness in accordance with the production fitness information. The techniques further include using a statistical model for a protein characteristic other than production fitness to generate an amino acid sequence library having amino acid sequences that are both predicted to be production-fit and have the protein characteristic. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244774 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/1037 (20130101) C12N 2750/14143 (20130101) C12N 2750/14145 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403976 | Bakaletz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| INVENTOR(S) | Lauren O. Bakaletz (Columbus, Ohio); Steven D. Goodman (Columbus, Ohio) |
| ABSTRACT | Disclosed are approaches to determining a sensitivity of a bacterium to a given antibiotic and generating targeted treatments based on the sensitivity. One or more antibiotics may be selected for a chronic/recurrent infection resulting from a biofilm so as to reduce dose and or length of course of antibiotic treatment. For example, if a bacterial pathogen is determined to be sensitive to an antibiotic in its planktonic form but resistant to that antibiotic in its biofilm form, then the biofilm may be dispersed or disrupted from the biofilm residence in order to clear the infection. In various embodiments, a dispersal or disruption method and/or agent may be determined based at least in part on a rate of bacterial release from a biofilm that sensitizes the pathogen to a chosen antibiotic. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/364578 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403978 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Robinson (Berkeley, California); Cheng-Ting Tsai (Berkeley, California); Carolyn Bertozzi (Stanford, California) |
| ABSTRACT | Methods are provided for detecting antigen binding agents in samples. Aspects of the methods include detection of the aggregation of antigen binding agents with polynucleotide-bound antigens by sensitive proximity-based association of the anti-gen-bound polynucleotides. Aspects of the methods also include methods for the detection of such proximity-based association through nucleic acid amplification. In addition, compositions, e.g., reagents, kits, and devices, useful in practicing various embodiments of the methods are provided. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474424 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6804 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 2525/117 (20130101) C12Q 2525/155 (20130101) C12Q 2525/197 (20130101) C12Q 2531/113 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403979 | Ellington et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Ellington (Austin, Texas); Yu Sherry Jiang (Austin, Texas); Sanchita Bhadra (Austin, Texas); Bingling Li (Austin, Texas); Randy Allen Hughes (Austin, Texas); Yan Du (Austin, Texas); Jimmy Gollihar (Hewitt, Texas) |
| ABSTRACT | Disclosed are methods for isothermal nucleic acid amplification and detection. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168940 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403994 | Williams et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Zev Williams (New York, New York); Shan Wei (New York, New York) |
| ABSTRACT | The present disclosure relates to improved methods for preparing, sequencing and analyzing short DNA fragments using handheld, nanopore-based sequencing technology as well as improved methods for extracting DNA, in particular genomic DNA, for any downstream application. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/468065 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404002 | Taylor |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hugh Taylor (Easton, Connecticut) |
| ABSTRACT | Disclosed herein are methods for developing and using quantitative algorithms, cutoff points, and numerical scores based upon the expression level of at least one miRNA that is associated with endometriosis. |
| FILED | Thursday, October 31, 2019 |
| APPL NO | 17/289882 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404014 | Garraway et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); BROAD INSTITUTE, INC. (Cambridge, Massachusetts) |
| INVENTOR(S) | Levi A. Garraway (Newton, Massachusetts); Cory M. Johannessen (Roslindale, Massachusetts) |
| ABSTRACT | A method of identifying a subject having cancer who is likely to benefit from treatment with a combination therapy with a RAF inhibitor and a second inhibitor is provided. A method of treating cancer in a subject in need thereof is also provided and includes administering to the subject an effective amount of a RAF inhibitor and an effective amount of a second inhibitor, wherein the second inhibitor is a MEK inhibitor, a CRAF inhibitor, a CrkL inhibitor or a TPL2/COT inhibitor. A method of identifying a kinase target that confers resistance to a first inhibitor is also provided. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357642 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4184 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 9/1205 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Enzymes C12Y 207/11024 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404016 | Chopra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sameer Chopra (Los Angeles, California); Jie Liu (San Mateo, California); Inderbir Singh Gill (Pasadena, California); Kimberly Siegmund (San Marino, California); Gangning Liang (Rowland Heights, California) |
| ABSTRACT | A method of classifying kidney tumors is provided. The method includes obtaining a sample from a subject, isolating DNA from the sample, determining the methylation status of the DNA, and comparing the methylation status of the DNA to one or more methylated biomarkers selected from the following: cg04877910, cg09667289, cg05274650, cg11473616, cg16935734, cg27534624, cg21851713, cg15867829, cg15679829, cg08884979, cg09538401, cg26811868, cg05367028, cg19816080, cg20108357, cg25504868, cg11201447, cg19922137, cg14706317, cg15902830, cg10794973, cg10777887, cg03290131, cg07851269, cg11264947, cg00279406, cg23140965, cg03574652, cg03265671, cg24864241, cg01572891, cg00193963, cg14329285, cg17819990, cg17298239, cg23856138, cg21049501, cg11808936, cg25170591, cg17983632, cg08141142, cg19848599, cg25799109, cg07093324, cg16223546, cg07604732, cg12149606, cg08949329, cg27166177, cg26177041, cg09885851, cg22876153, cg21386992, cg02309772, cg02833180, cg20007890, cg04972244, cg02666955 and cg12102682. The comparison indicates whether the sample is clear cell malignant, papillary malignant, chromophobe malignant, angiomylolipomas (AML) benign, or oncocytoma benign. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399920 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6858 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/50 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404915 | Bomsztyk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karol Bomsztyk (Seattle, Washington); Stephen Scheuerman (Seattle, Washington) |
| ABSTRACT | The present technology generally relates to a tissue sample coring system. Select embodiments of a tissue sample core extractor include a drill head, a drill bit, a tube, and a pump. The drill bit may have a hollow coring head configured to separate a core from a tissue sample and retain the core therein. The drill bit may include a central passageway fluidly coupling the hollow coring head to a port extending radially from the central passageway through the drill bit, where the tube is aligned with the port and movable to selectively abut the drill bit to create a fluid seal between the tube and the port such that the pump can cause a fluid to flow through the tube, pressurize the central passageway, and eject the core. The tissue sample core extractor may further include a trigger configured to move the tube and/or cycle the pump. |
| FILED | Thursday, October 24, 2019 |
| APPL NO | 17/287950 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0266 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404917 | Mayerich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | David Mayerich (Houston, Texas); Jason Eriksen (Houston, Texas) |
| ABSTRACT | Milling with ultraviolet excitation (MUVE) realizes high-throughput multiplex imaging of large three-dimensional samples. The instrumentation may comprise a UV-source attachment, precision stage attachment, and/or a blade assembly, and the instrumentation may overcome several constraints inherent to current state-of-the-art three-dimensional microscopy. MUVE offers throughput that is orders of magnitude faster than other technology by collecting a two-dimensional array of pixels simultaneously. The proposed instrumentation also utilizes serial ablation and provides the opportunity for true whole-organ imaging at microscopic resolution. |
| FILED | Friday, November 15, 2019 |
| APPL NO | 17/294489 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 1/36 (20130101) G01N 1/286 (20130101) G01N 21/6458 (20130101) G01N 2001/302 (20130101) G01N 2001/364 (20130101) G01N 2001/2873 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404918 | HURTADO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Romulo HURTADO (Ithaca, New York) |
| ABSTRACT | A method for rendering biological tissue sufficiently optically transparent for three-dimensional light microscopy imaging, comprising incubating biological tissue with an optical clearing solution, wherein the optical clearing solution comprises: (i) 20-50 wt % formamide, (ii) 10-90 wt % glycerol, and (iii) water as remainder. Also described herein is a method for ridding tissue of blood to make them amenable for optical clearing, comprising incubating biological tissue in a decolorizing solution, wherein the decolorizing solution comprises: (i) 0.5-3 wt % hydrogen peroxide, (ii) 0.05-1 wt % sodium azide, (iii) 5-20 wt % DMSO, and (iv) phosphate buffered saline as a remained. Also described herein is a method for reducing auto-fluorescence in biological tissue to permit imaging of the biological tissue in a fluorescence-based imaging technique with enhanced resolution, wherein the auto-fluorescence quenching solution comprises: 1-100 mM ammonium bicarbonate, (ii) 20-500 M copper sulfate, (iii) 5-20 wt % DMSO, and (iv) water as remainder. |
| FILED | Wednesday, November 20, 2019 |
| APPL NO | 17/294504 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 33/5058 (20130101) G01N 33/5061 (20130101) G01N 2021/6432 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404958 | MIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WEI MIN (Fort Lee, New Jersey); LIXUE SHI (Zhejiang, China PRC); HANQING XIONG (Hubei, China PRC); LU WEI (Anhui, China PRC) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | WEI MIN (Fort Lee, New Jersey); LIXUE SHI (Zhejiang, China PRC); HANQING XIONG (Hubei, China PRC); LU WEI (Anhui, China PRC) |
| ABSTRACT | Exemplary computer-accessible medium, systems, and methods are described herein which can provide an excited fluorescence radiation. In accordance with certain exemplary embodiments of the present disclosure, an excited fluorescence radiation can be provided using a beam of a probe so as to excite a molecule to an excited state for a fluorescence emission to effectuate the excited fluorescence radiation. The molecule can be detected based on the fluorescence emission. For example, the beam of the probe can be either the near-infrared spectrum or the visible light spectrum. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473259 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) G01N 21/636 (20130101) Original (OR) Class G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 2021/655 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405029 | ADZHUBEI et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexei ADZHUBEI (Moscow, Russian Federation); Michael BUKRINSKY (Potomac, Maryland); Ruth HUNEGNAW (Arlington, Virginia) |
| ABSTRACT | The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/410882 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/167 (20130101) A61K 31/404 (20130101) Acyclic or Carbocyclic Compounds C07C 223/06 (20130101) C07C 381/00 (20130101) Heterocyclic Compounds C07D 209/56 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 33/5041 (20130101) Original (OR) Class G01N 2333/163 (20130101) G01N 2333/4727 (20130101) G01N 2500/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405041 | QIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Zhenpeng QIN (Allen, Texas); Yaning LIU (Richardson, Texas); Jeffrey S. KAHN (Plano, Texas); Leonidas BLERIS (Allen, Texas); Haihang YE (Dallas, Texas) |
| ABSTRACT | The disclosure relates to particle-based assays for the detection of analytes. Using various combinations of particular technologies, including gold nanorods, silver nanoparticles, gold/silver nanoshells, gold/silver nanocages and nanobubble detection, enhanced detection limits can be achieved across a large range of analytes. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358688 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54346 (20130101) Original (OR) Class G01N 33/56983 (20130101) G01N 2333/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405064 | Mei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Clemson University Research Foundation (Clemson, South Carolina); MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ying Mei (Mount Pleasant, South Carolina); Jia Jia (Charleston, South Carolina); Chung-Jen James Chou (Mount Pleasant, South Carolina) |
| ABSTRACT | The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation and is useful for bioprinting. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 17/476971 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/52 (20130101) C07K 14/71 (20130101) C07K 14/75 (20130101) C07K 14/78 (20130101) C07K 14/755 (20130101) C07K 14/70546 (20130101) C07K 17/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2333/70557 (20130101) G01N 2500/04 (20130101) G01N 2500/20 (20130101) G01N 2800/7014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405074 | Kaddurah-Daouk et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rima F. Kaddurah-Daouk (Belmont, Massachusetts); Jon B. Toledo (Philadelphia, Pennsylvania); Matthias Arnold (Neuherberg, Germany); Gabi Kastemüller (Neuherberg, Germany); Rebecca A. Baillie (San Carlos, California); Xianlin Han (Orlando, Florida); Will Thompson (Durham, North Carolina); Lisa St. John-Williams (Durham, North Carolina); Therese Koal (Innsbruck, Austria); Kwangsik Nho (Indianapolis, Indiana); M. Arthur Moseley (Raleigh, North Carolina); Andrew J. Saykin (Indianapolis, Indiana); Pudugramam Murali Doraiswamy (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rima F. Kaddurah-Daouk (Belmont, Massachusetts); Jon B. Toledo (Philadelphia, Pennsylvania); Matthias Arnold (Neuherberg, Germany); Gabi Kastemüller (Neuherberg, Germany); Rebecca A. Baillie (San Carlos, California); Xianlin Han (Orlando, Florida); Will Thompson (Durham, North Carolina); Lisa St. John-Williams (Durham, North Carolina); Therese Koal (Innsbruck, Austria); Kwangsik Nho (Indianapolis, Indiana); M. Arthur Moseley (Raleigh, North Carolina); Andrew J. Saykin (Indianapolis, Indiana); Pudugramam Murali Doraiswamy (Chapel Hill, North Carolina) |
| ABSTRACT | Embodiments of the present disclosure relate generally to the analysis and identification of global metabolic changes in Alzheimer's disease (AD). More particularly, the present disclosure provides materials and methods relating to the use of metabolomics as a biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to cerebrospinal fluid pathology markers, imaging features, and cognitive performance. Defining metabolic changes during AD disease trajectory and their relationship to clinical phenotypes provides a powerful roadmap for drug and biomarker discovery. |
| FILED | Friday, September 08, 2017 |
| APPL NO | 16/331940 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405228 | McCollough et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cynthia H. McCollough (Byron, Minnesota); Zhoubo Li (Libertyville, Illinois); Shuai Leng (Rochester, Minnesota) |
| ABSTRACT | Described here are systems and methods for optimization techniques for automatically selecting x-ray beam spectra, energy threshold, energy bin settings, and other imaging technique parameters for photon-counting detector computed tomography (“PCCT”). The techniques described here are generally based on subject or object size, material of interest, and location of the target material. Advantageously, the optimizations can be integrated with different PCCT systems to automatically select optimal imaging technique parameters before scanning a particular subject or object. |
| FILED | Thursday, September 09, 2021 |
| APPL NO | 17/470566 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/482 (20130101) A61B 6/545 (20130101) A61B 6/4241 (20130101) A61B 6/5258 (20130101) Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 18/00 (20130101) Measurement of Nuclear or X-radiation G01T 1/2985 (20130101) G01T 7/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406611 | Xie |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Chensu Xie (New York, New York) |
| ABSTRACT | Presented herein are systems and methods for feature detection in images. A computing system may identify a biomedical image having features. The computing system may apply the biomedical image to a feature detection model. The feature detection model may include an encoder-decoder block to generate a feature map corresponding to the biomedical image, a confidence map generator having a second set of parameters to generate a confidence map using the feature map, and a localization map generator to generate a localization map using the feature map. The computing system may generate a resultant map based on the confidence map and the localization map. The resultant map identifying one or more points corresponding to the one or more features. The computing system may provide the one or more points identified in the resultant map for the biomedical image. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473225 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/6232 (20130101) G06K 9/6265 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10056 (20130101) G06T 2207/30061 (20130101) G06T 2207/30068 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210407620 | Westerhoff et al. |
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| FUNDED BY |
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| APPLICANT(S) | QuantumBio Inc. (state College, Pennsylvania) |
| ASSIGNEE(S) | QuantumBio Inc. (State College, Pennsylvania) |
| INVENTOR(S) | Lance Michael Westerhoff (Annville, Pennsylvania); Oleh Y. Borbulevych (Bellefonte, Pennsylvania); Roger Isaac Martin (State College, Pennsylvania) |
| ABSTRACT | The invention is a diagnostic which overlays quantum mechanical analysis to x-ray crystallography or Cryo-EM data from one or more molecules, to assess and identify the real world conformation, protonation and solvent effects of one or more moieties in said molecule. This “overlay” occurs by scoring and identifying the protomer/tautomer or conformational states of the moieties using quantum mechanical analysis. The diagnostic results of the present invention accurately identify protein-ligand binding, rendered as an output to a user of a computer in which the x-ray crystallography or Cryo-EM data is analysed with semi-empirical Hamiltonian quantum mechanics. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348074 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/20008 (20130101) G01N 33/6803 (20130101) G01N 2223/304 (20130101) G01N 2223/612 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Original (OR) Class G16B 20/00 (20190201) G16B 20/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210407624 | BUSSEMAKER et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Harmen H. BUSSEMAKER (New York, New York); Chaitanya RASTOGI (New York, New York); Hans Tomas RUBE (New York, New York) |
| ABSTRACT | The disclosed subject matter provides systems and methods for identifying bioactivities of biopolymers from sequence data of the biopolymers. The disclosed system can include a processor configured to receive the input data and a storage medium including instructions operable when executed by the processors. The instructions can cause the system to obtain the input data and generate an evaluative model configured to acquire a biophysical model parameter, a model interaction parameter, a count table parameter, or combinations thereof utilizing the input data. The evaluative model can be configured to simultaneously use multiple biophysical models to represent one or more sequence recognition modes of the biopolymers, evaluate the biopolymers using the evaluative model, and generate a value using the evaluating model that corresponds to the bioactivity of each biopolymer. |
| FILED | Wednesday, September 15, 2021 |
| APPL NO | 17/476113 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 30/00 (20190201) G16B 35/20 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210407627 | Schramm et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | Albert Einstein College of Medicine (Bronx, New York) |
| INVENTOR(S) | Vern L. Schramm (New Rochelle, New York); Quan Du (Bronx, New York); Zhen Wang (Feicheng, China PRC) |
| ABSTRACT | Methods and systems for obtaining inhibitors of human DNA methyltransferase 1 (DNMT1) are disclosed where the methods involve designing compounds that resemble the DNMT1 transition state. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466790 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1007 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/48 (20130101) Enzymes C12Y 201/01037 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/10 (20190201) G16C 20/50 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20210401294 | Cole et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Aaron Boyd Cole (Bloomington, Indiana); Marcin Stanislaw Malec (Bloomington, Indiana) |
| ABSTRACT | A temperature detection system and method for detecting a correlation between temperatures on a subject and a temperature reference is provided. One or more calibrated temperature reference devices, such as a Body Temperature Reference blackbody system is used with an emissive source detector, such as a Mid Wave Infrared (MWIR) or Long Wave Infrared (LWIR) thermal camera that is capable of imaging both a subject and the calibrated temperature reference devices. A processor maps each pixel within the image to a specific thermal value based on the mean and median reference temperatures from the calibrated temperature reference devices and identifies any pixel in the image having a temperature greater than the reference temperature. This information can be used to detect an elevated temperature from a subject. The system and method can be used to detect fevers, tumors, infections, parasites, and the like. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358404 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/015 (20130101) Original (OR) Class A61B 5/1176 (20130101) A61B 5/7425 (20130101) A61B 2560/0223 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00228 (20130101) G06K 9/00288 (20130101) G06K 9/6228 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 7/0014 (20130101) G06T 2207/10048 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401594 | Perry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | N. Christopher Perry (Manchester, New Hampshire); Keith D. Violette (Sandown, New Hampshire); Grant A. Peret (Bedford, New Hampshire); David D.B. Cannan (Manchester, New Hampshire); Christopher C. Langenfeld (Nashua, New Hampshire); Jacob P. Laplante (Manchester, New Hampshire); Thomas A. Doyon (Manchester, New Hampshire) |
| ABSTRACT | A prosthetic device. The prosthetic device may include a flexure cut and/or a sensor to detect movement in accordance with a degree of movement. In an embodiment, the sensor may be disposed within the flexure cut. Other embodiments include at least one wire configured to connect a sensor located in a distal portion to a proximal portion, while annularly traversing a joint. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/338727 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/50 (20130101) A61F 2/54 (20130101) A61F 2/70 (20130101) A61F 2/76 (20130101) Original (OR) Class A61F 2/586 (20130101) A61F 2002/704 (20130101) A61F 2002/5072 (20130101) A61F 2002/6863 (20130101) A61F 2002/7615 (20130101) A61F 2002/7635 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401874 | Golobish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CytoSorbents Corporation (Monmouth Junction, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Golobish (Princeton, New Jersey); Maryann Gruda (Yardley, Pennsylvania); Tamaz Guliashvili (Philadelphia, Pennsylvania); Pamela O'Sullivan (Manalapan, New Jersey); Andrew Scheirer (Hoboken, New Jersey); Vi Dan (East Brunswick, New Jersey); Wei-Tai Young (Hillsborough, New Jersey); Vincent Capponi (Lawrenceville, New Jersey); Phillip Chan (Cherry Hill, New Jersey) |
| ABSTRACT | The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/341912 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/795 (20130101) Original (OR) Class A61K 47/20 (20130101) A61K 47/26 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3679 (20130101) A61M 5/165 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/264 (20130101) B01J 20/267 (20130101) B01J 20/28069 (20130101) B01J 39/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402000 | Jiang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Shaoyi Jiang (Seattle, Washington); Zhefan Yuan (Seattle, Washington); Liqian Niu (Seattle, Washington) |
| ABSTRACT | High-polymer-density bioconjugate compositions including multi-layer polymer bioconjugates, polymer backfilled bioconjugates, and multi-layer polymer backfilled bioconjugates, and methods for making the compositions. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 17/283731 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/593 (20170801) A61K 47/6425 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402075 | Golobish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CytoSorbents Corporation (Monmouth Junction, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. Golobish (Princeton, New Jersey); Vincent J. Capponi (Lawrenceville, New Jersey); David R. Clay (West Orange, New Jersey) |
| ABSTRACT | The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313424 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/02 (20130101) A01N 1/0215 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/34 (20130101) A61M 1/36 (20130101) A61M 1/0272 (20130101) A61M 1/3679 (20130101) Original (OR) Class Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/261 (20130101) B01J 20/267 (20130101) B01J 20/3208 (20130101) B01J 20/3246 (20130101) B01J 20/3248 (20130101) B01J 20/3251 (20130101) B01J 20/3272 (20130101) B01J 20/3282 (20130101) B01J 20/3285 (20130101) B01J 20/28069 (20130101) B01J 20/28078 (20130101) B01J 20/28092 (20130101) B01J 2220/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402090 | Damiano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BETA BIONICS, INC. (Concord, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward R. Damiano (Acton, Massachusetts); Firas H. El-Khatib (Allston, Massachusetts) |
| ABSTRACT | A blood glucose control system is configured to modify therapy provide to a subject and determine whether the modified therapy results in a statistically significant improvement in glycemic control. The system obtains glycemic control information resulting from delivery of first therapy using a first value of a control parameter and determines a first effect corresponding to the first therapy. The control parameter is set to a second value that differs from the first value. The system obtains glycemic control information resulting from the delivery of the second therapy using the second value of the control parameter and determines a second effect corresponding to the second therapy. The system can perform a comparative assessment and determine whether the second value for the control parameter results in a statistically significant improvement in glycemic control for the subject. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/194030 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 5/14244 (20130101) A61M 2005/1726 (20130101) A61M 2005/14208 (20130101) A61M 2205/16 (20130101) A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/505 (20130101) A61M 2205/3553 (20130101) A61M 2205/3561 (20130101) A61M 2205/3584 (20130101) A61M 2205/3592 (20130101) A61M 2230/201 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 20/17 (20180101) G16H 20/60 (20180101) G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402186 | Edgerton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California); University of Louisville Research Foundation, Inc. (Louisville, Kentucky); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor Reggie Edgerton (Los Angeles, California); Roland R. Roy (Playa Vista, California); Yury Gerasimenko (Los Angeles, California); Joel W. Burdick (Pasadena, California); Susan J. Harkema (Louisville, Kentucky); Jonathan Hodes (Louisville, Kentucky); Yu-Chong Tai (Pasadena, California); Mandheerej S. Nandra (Pasadena, California); Claudia A. Angeli (Lousiville, Kentucky); Thomas Anthony Desautels (Pasadena, California) |
| ABSTRACT | Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having a spinal cord injury, a brain injury, or a neurological neuromotor disease are described. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473406 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0237 (20130101) A61H 1/0274 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0551 (20130101) A61N 1/0553 (20130101) A61N 1/0556 (20130101) A61N 1/36003 (20130101) A61N 1/36103 (20130101) Original (OR) Class Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 21/00181 (20130101) A63B 69/0064 (20130101) Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps F04C 2270/0421 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402465 | Propheter-Hinckley |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tracy A. Propheter-Hinckley (Manchester, Connecticut) |
| ABSTRACT | A method and casting core for forming a landing for welding a baffle inserted into an airfoil are disclosed, wherein the baffle landing of the blade or vane is formed in investment casting by the casting core rather than by wax, reducing tolerances and variability in the location of the baffle inserted into the cooling cavity of airfoil when the baffle is welded to the baffle landing. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362092 |
| CURRENT CPC | Foundry Moulding B22C 1/00 (20130101) B22C 9/04 (20130101) B22C 9/10 (20130101) B22C 9/18 (20130101) B22C 9/24 (20130101) B22C 9/103 (20130101) B22C 9/108 (20130101) Casting of Metals; Casting of Other Substances by the Same Processes or Devices B22D 25/02 (20130101) Original (OR) Class B22D 29/001 (20130101) Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/188 (20130101) F01D 9/041 (20130101) F01D 25/12 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/211 (20130101) F05D 2230/232 (20130101) F05D 2240/12 (20130101) F05D 2240/30 (20130101) F05D 2240/126 (20130101) F05D 2260/201 (20130101) F05D 2300/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402478 | Nault et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isaac Michael Nault (Bel Air, Maryland); Kenneth W. Young (Bear, Delaware); Gehn D. Ferguson (Baltimore, Maryland); Aaron T. Nardi (East Granby, Connecticut) |
| ABSTRACT | A method of determining a tool path for an additive deposition on a surface, the method including receiving primary edges data of the surface of a three-dimensional (3D) object; calculating a number of raster lines for applying an additive deposition on the surface; mapping a raster pattern to the surface of the 3D object; calculating surface normal and rotational angles along the raster lines; calculating a nozzle velocity of an additive application used for producing the additive deposition on the surface; identifying curvature effects of the 3D object; and establishing an order of performing passes of the additive deposition on the surface based on a selected direction for performing the additive deposition and a consideration of a residual stress profile of a resulting deposit. |
| FILED | Tuesday, May 25, 2021 |
| APPL NO | 17/329811 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/25 (20210101) B22F 10/34 (20210101) B22F 10/38 (20210101) Original (OR) Class B22F 10/85 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402482 | Ferguson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army DEVCOM, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gehn D. Ferguson (Baltimore, Maryland); Kenneth W. Young (Bear, Delaware); Isaac M. Nault (Baltimore, Maryland); Brian Sparber (Media, Pennsylvania); Aaron T. Nardi (East Granby, Connecticut) |
| ABSTRACT | A system and method for controlling cold spray deposit adhesion for induced release of a deposit from a substrate includes tuning a material surface condition of a substrate used to support a build of a cold spray material to a level proportionate with deposition conditions of the cold spray material for adhesion to the substrate; selecting an impact velocity for deposition of the cold spray material to be substantially equal to or greater than a critical velocity for adhesion of the cold spray material to the substrate; depositing the cold spray material on the substrate to form a deposit; and releasing the deposit from the substrate without permanently damaging the substrate to allow for reuse of the substrate for a subsequent cold spray deposition process. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344204 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/25 (20210101) B22F 12/30 (20210101) B22F 12/88 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 24/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402534 | Tindal |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mitchell Tindal (Hartland, Wisconsin) |
| ABSTRACT | A tripod jack cylinder removal tool including a lifting eyebolt attached through an up flange and further through and up flange aperture to a lock nut. The flange is secured to a pipe at a pipe top end, the pipe further having a bottom end wherein a down flange having a down flange aperture is attached to the pipe and a bolt having threads protrudes through a down flange aperture. |
| FILED | Sunday, May 23, 2021 |
| APPL NO | 17/327738 |
| CURRENT CPC | Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 19/04 (20130101) Original (OR) Class Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402654 | Repko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Alexander James Repko (Pittsburgh, Pennsylvania); Kacey Gribbin Marra (Canonsburg, Pennsylvania); Benjamin Schilling (Pittsburgh, Pennsylvania) |
| ABSTRACT | The presently disclosed subject matter relates to systems for making an implantable construct comprising a reservoir coupled to the at least one frame; a mandrel base coupled to the at least one frame; a mandrel coupled to the mandrel base; a first mechanism configured to be coupled to the at least one frame and configured to move the at least one frame along a first axis; a second mechanism configured to be coupled to the at least one frame and configured to rotate the least one mandrel base along a second axis between a first orientation and a second orientation; and a container configured to be coupled to the at least one frame and configured to receive the mandrel in the second orientation. The disclosed mechanisms can manually, semi-automatically, or automatically control the movements of the at least one frame, reservoir, mandrel, mandrel base, and container to produce the construct with a lumen. The presently disclosed subject matter also relates to methods for making the construct. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474197 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 41/14 (20130101) Original (OR) Class B29C 41/22 (20130101) B29C 41/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403141 | BUKOVEC et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bell Textron Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | Bell Textron Inc. (Fort Worth, Texas) |
| INVENTOR(S) | Robert Allen BUKOVEC (Dallas, Texas); Nathaniel David BRYANT (Dallas, Texas); Levi Charles HEFNER (Dallas, Texas) |
| ABSTRACT | An example of a collapsible pylon for a drone aircraft includes a bore extending through a length of a barrel, a first and a second flex-pin bore formed through a wall of the barrel, a first arm slidably positioned within a first end of the bore, a first flex pin disposed on the first arm to engage the first flex-pin bore, a second arm slidably positioned within a second end of the bore, and a second flex pin disposed on the second arm to engage the second flex-pin bore. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/917547 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 9/34 (20130101) Original (OR) Class B64C 2201/165 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210403158 — INFINITE WIRELESS CHARGING OF A UAS (UNMANNED AERIAL SYSTEM) WITH POWER INFRASTRUCTURE
| US 20210403158 | Jeong |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seong Heon Jeong (Tuscaloosa, Alabama) |
| ABSTRACT | Systems and methods for enabling infinite wireless charging of unmanned aerial systems (UASs) are provided. A UAS detects sources of power and wirelessly charges itself by collecting ambient electromagnetic energy from a power infrastructure. A UAS in accordance with features and aspects described herein is autonomous, may always be wirelessly charged (e.g., with high induced voltage), and can make use of weak energy. Moreover, various charging techniques can be used, such as in-flight, trickle, perching, and/or parking. Dynamic flight is supported using multi-angle MIMO coils. Additionally or alternatively, faster charging can be achieved with a supercapacitor and slower charging can be achieved with a battery. |
| FILED | Thursday, December 17, 2020 |
| APPL NO | 17/124720 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) Original (OR) Class B64C 2201/066 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/345 (20130101) H02J 50/005 (20200101) H02J 50/10 (20160201) H02J 2207/50 (20200101) H02J 2310/44 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403179 | Muhleman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Naval Information Warfare Center, Pacific (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by Secretary of the Navy (San Diego, California) |
| INVENTOR(S) | Daniel H. Muhleman (El Cajon, California) |
| ABSTRACT | A space-based circuit-replacing robotic system and method include a satellite grasper configured to grasp the satellite having a printed circuit onto which an integrated circuit is soldered and the integrated circuit is to be replaced; an access mechanism configured to remove the printed circuit and/or to provide access to the printed circuit; a printed circuit orientation device configured to orient a printed circuit such that sunlight is incident on the printed circuit; one or more temperature sensors configured to measure a temperature of the solder on the printed circuit; a processor configured to adjust a rate of heating to match a desired heating rate; a circuit grasping device configured to position the circuit for replacement; and an optical shield that is configured to be adjusted to allow light to pass substantially only to a desired area of the printed circuit. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 16/913364 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0016 (20130101) B23K 2101/42 (20180801) Cosmonautics; Vehicles or Equipment Therefor B64G 1/1078 (20130101) Original (OR) Class B64G 4/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/95607 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 22/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403184 | Hejmanowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CU Aerospace, LLC (Champaign, Illinois) |
| ASSIGNEE(S) | CU Aerospace, LLC (Champaign, Illinois) |
| INVENTOR(S) | Neil Hejmanowski (Urbana, Illinois); Alex Ghosh (Brambleton, Virginia); David L. Carroll (Champaign, Illinois) |
| ABSTRACT | The Guideless Resilient Androgynous Serial Port (GRASP) mechanism provides an androgynous mechanical and electrical interface that can be tailored to the meet the requirements of a given application. Each mechanism is equipped with physical connections (spring pins) for both power and data transmission between modules. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375371 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/646 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403538 | CROWE, Jr. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. CROWE, Jr. (Nashville, Tennessee); Pavlo GILCHUK (Nashville, Tennessee); Alexander BUKREYEV (Galveston, Texas) |
| ABSTRACT | The present disclosure is directed to human antibodies binding to and neutralizing ebolavirus and methods for use thereof. A further embodiment involves a monoclonal antibody, wherein the antibody or antibody fragment is characterized by clone-paired heavy and light chain CDR sequences. In yet another embodiment, there is provided a hybridoma or engineered cell encoding an antibody or antibody fragment. An additional embodiment comprises a vaccine formulation comprising one or more antibodies or antibody fragments characterized by clone-paired heavy and light chain CDR sequences. In still a further embodiment, there is provided a method of protecting the health of a placenta and/or fetus of a pregnant a subject infected with or at risk of infection with ebolavirus comprising delivering to said subject the antibody or antibody fragment. |
| FILED | Thursday, July 11, 2019 |
| APPL NO | 17/259263 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2469/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403649 | Sheikhi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Amir Sheikhi (State College, Pennsylvania); Dino Di Carlo (Los Angeles, California); Alireza Khademhosseini (Los Angeles, California); Joseph de Rutte (Los Angeles, California) |
| ABSTRACT | Despite the significant advances in designing injectable bulk hydrogels, the inability to control the pore interconnectivity and decoupling it from the matrix stiffness has tremendously limited the applicability of stiff, flowable hydrogels for 3D cellular engineering. To address this problem, we developed a universal method to convert macromolecules and the like with orthogonal chemical and/or physical responsivity, e.g., thermosensitive macromolecules with chemically-crosslinkable moieties, into annealable building blocks, forming 3D microporous beaded scaffolds in a bottom-up approach. For example, gelatin methacryloyl (GelMA), a widely used biomaterial in tissue engineering, may be converted into physically-crosslinked microbeads using a facile microfluidic approach, followed by flow of the microbead slurry and chemical crosslinking in situ to fabricate microporous beaded GelMA (B-GelMA) scaffolds with interconnected pores, promoting cell functionality and rapid (within minutes) 3D seeding in stiff scaffolds, which are otherwise impossible in the bulk gel counterparts. |
| FILED | Friday, October 18, 2019 |
| APPL NO | 17/279283 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/56 (20130101) A61L 27/222 (20130101) A61L 2400/06 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 3/075 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403887 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Basil Hubbard (Cambridge, Massachusetts); Ahmed Hussein Badran (Cambridge, Massachusetts) |
| ABSTRACT | Engineered transcriptional activator-like effectors (TALEs) are versatile tools for genome manipulation with applications in research and clinical contexts. One current drawback of TALEs is that the 5′ nucleotide of the target is specific for thymine (T). TALE domains with alternative 5′ nucleotide specificities could expand the scope of DNA target sequences that can be bound by TALEs. Another drawback of TALEs is their tendency to bind and cleave off-target sequence, which hampers their clinical application and renders applications requiring high-fidelity binding unfeasible. This disclosure provides methods and strategies for the continuous evolution of proteins comprising DNA-binding domains, e.g., TALE domains. In some aspects, this disclosure provides methods and strategies for evolving such proteins under positive selection for a desired DNA-binding activity and/or under negative selection against one or more undesired (e.g., off-target) DNA-binding activities. Some aspects of this disclosure provide engineered TALE domains and TALEs comprising such engineered domains, e.g., TALE nucleases (TALENs), TALE transcriptional activators, TALE transcriptional repressors, and TALE epigenetic modification enzymes, with altered 5′ nucleotide specificities of target sequences. Engineered TALEs that target ATM with greater specificity are also provided. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 17/355735 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0066 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/62 (20130101) C12N 15/90 (20130101) C12N 15/8509 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403930 | Perkins et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SynPloid Biotek, LLC (Savannah, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Perkins (Savannah, Georgia); Amy Greene (Savannah, Georgia) |
| ABSTRACT | The present invention encompasses compositions and methods to allow one to deliver and express multiple genes from a biosynthetic pathway in a recipient cell via a synthetic chromosome. |
| FILED | Tuesday, April 11, 2017 |
| APPL NO | 16/092837 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/81 (20130101) Original (OR) Class C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403944 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts) |
| ABSTRACT | Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/468100 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403979 | Ellington et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Ellington (Austin, Texas); Yu Sherry Jiang (Austin, Texas); Sanchita Bhadra (Austin, Texas); Bingling Li (Austin, Texas); Randy Allen Hughes (Austin, Texas); Yan Du (Austin, Texas); Jimmy Gollihar (Hewitt, Texas) |
| ABSTRACT | Disclosed are methods for isothermal nucleic acid amplification and detection. |
| FILED | Friday, February 05, 2021 |
| APPL NO | 17/168940 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6844 (20130101) C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403983 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Shengxi Chen (Chandler, Arizona); Sidney Hecht (Phoenix, Arizona); Mingxuan Gao (Chongqing, China PRC) |
| ABSTRACT | Described herein are compositions that may be used to detect viral nucleic acid. For example, these compositions may comprise a DNA-nanostructure, a capture oligonucleotide and a protector oligonucleotide, wherein the components are designed based on a duo-toehold-mediated displacement reaction (duo-TMDR) strategy. In this strategy, a first TMDR can switch off a Faster resonance energy transfer (FRET) process and a second TMDR can release the target viral nucleic acid and amplify the signal. Methods of using such compositions are also provided herein. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370859 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2310/151 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/682 (20130101) C12Q 1/686 (20130101) C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404414 | Mocanu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Florin Mocanu (Columbus, Indiana); Eric M. Osecky (Indianapolis, Indiana); Robert G. Sperry (Columbus, Indiana); John M. Deur (Columbus, Indiana) |
| ABSTRACT | The present disclosure provides piston, comprising: a skirt having an upper body portion; a crown formed at the upper body portion; and a piston bowl formed at the crown. The piston bowl includes a first combustion surface and a second combustion surface opposite the first combustion surface. Each of the first combustion surface and the second combustion surface are formed and positioned to accommodate inflowing injector spray so as to reduce heat transfer caused by impingements made by the inflowing injector spray. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313954 |
| CURRENT CPC | Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 3/10 (20130101) F02F 3/26 (20130101) Original (OR) Class Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof F02M 61/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404418 | Carlson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Valley Tech Systems, Inc. (Reno, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell Carlson (Reno, Nevada); Dustin Barr (Reno, Nevada); Allen Yan (Reno, Nevada); Justin Carpenter (Loomis, California) |
| ABSTRACT | Various implementations of an extinguishable, solid propellant divert system for a flight vehicle are disclosed. Also disclosed are methods for using the divert system to control the flight of a flight vehicle. In one implementation, a divert system includes a hot gas generator pneumatically linked to one or more divert thrusters and an extinguishment valve. The extinguishment valve can be opened to rapidly depressurize the hot gas generator and extinguish the solid propellant burning inside. In another implementation, a method of controlling the trajectory of the flight vehicle includes repeatedly igniting and extinguishing the solid propellant in a hot gas generator and using the hot gas to provide divert thrust for the flight vehicle. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/447623 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/403 (20130101) Jet-propulsion Plants F02K 9/26 (20130101) Original (OR) Class F02K 9/94 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404450 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xi Chen (New York, New York); Rein Ulijn (New York, New York); Roxana Piotrowska (New York, New York) |
| ABSTRACT | A thin film that has a flexible polymer layer and a peptide layer. The peptide layer is disposed on the flexible polymer layer and has a peptide selected from HYF, DYF and YFD. The thin film reversibly curves with changes in humidity. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140639 |
| CURRENT CPC | Peptides C07K 5/0812 (20130101) C07K 5/0819 (20130101) C07K 5/0821 (20130101) Compositions of Macromolecular Compounds C08L 7/00 (20130101) C08L 21/02 (20130101) C08L 67/02 (20130101) C08L 69/00 (20130101) C08L 79/08 (20130101) C08L 83/04 (20130101) C08L 2203/16 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404957 | MEYER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Jerry R. MEYER (Catonsville, Maryland); Igor VURGAFTMAN (Severna Park, Maryland); Chadwick Lawrence CANEDY (Washington, District of Columbia); William W. BEWLEY (Falls Church, Virginia); Chul Soo KIM (Springfield, Virginia); Charles D. MERRITT (Fairfax, Virginia); Michael V. WARREN (Arlington, Virginia); R. Joseph WEIBLEN (Washington, District of Columbia); Mijin KIM (Springfield, Virginia) |
| ABSTRACT | Building blocks are provided for on-chip chemical sensors and other highly-compact photonic integrated circuits combining interband or quantum cascade lasers and detectors with passive waveguides and other components integrated on a III-V or silicon. A MWIR or LWIR laser source is evanescently coupled into a passive extended or resonant-cavity waveguide that provides evanescent coupling to a sample gas (or liquid) for spectroscopic chemical sensing. In the case of an ICL, the uppermost layer of this passive waveguide has a relatively high index of refraction that enables it to form the core of the waveguide, while the ambient air, consisting of the sample gas, functions as the top cladding layer. A fraction of the propagating light beam is absorbed by the sample gas if it contains a chemical species having a fingerprint absorption feature within the spectral linewidth of the laser emission. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407261 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/1895 (20130101) G01J 3/2803 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/27 (20130101) G01N 21/59 (20130101) Original (OR) Class G01N 21/255 (20130101) Optical Elements, Systems, or Apparatus G02B 6/102 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/101 (20130101) H01S 5/125 (20130101) H01S 5/0215 (20130101) H01S 5/0262 (20130101) H01S 5/0287 (20130101) H01S 5/343 (20130101) H01S 5/0421 (20130101) H01S 5/0612 (20130101) H01S 5/2063 (20130101) H01S 5/2206 (20130101) H01S 5/3402 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404963 | SHEPARD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (, None) |
| INVENTOR(S) | Kenneth SHEPARD (Ossining, New York); Girish RAMAKRISHNAN (New York, New York) |
| ABSTRACT | Systems and methods for performing non-destructive sensing of a cell or tissue, in vivo or in culture, are provided. The disclosed systems and methods include fabricating and powering one or more implantable integrated circuit (IC) chips that include a network of Photovoltaic (PV) cells for energy harvesting from an optical energy source, an optical modulator integrating Quantum Dot capacitors (QD-caps) for optical data transfer using fluorescence modulation, and sensing circuitry. The IC chip disclosed herein can measure a thickness of around 10 μm, allowing injection into small cells and diffusion through tissue, it is powered and imaged under a microscope and communicates using fluorescence modulation imaged under a microscope. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/360667 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0031 (20130101) A61B 2560/0214 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/025 (20130101) G02F 1/0157 (20210101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/02327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405015 | Niemann |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey D. Niemann (Fort Collins, Colorado) |
| ABSTRACT | Systems and methods are disclosed to downscale the resolution of a coarse-resolution soil moisture data. Coarse-resolution soil moisture data may include data cells that each represent a geographic region having at least one dimension greater than or equal to 1 km. A plurality of fine-resolution supplemental soil moisture data may be received that includes at least one of soil data, vegetation data, topography data, and climate data. The fine-resolution supplemental soil moisture data comprising data cells that each represent a geographic region having at least one dimension less than or equal to 100 meters. The coarse-resolution soil moisture data may be downscaled to fine-resolution soil moisture data using the plurality of fine-resolution supplemental soil moisture data, the fine-resolution soil moisture data comprising data cells that each represent a geographic region having at least one dimension less than 100 meters. |
| FILED | Wednesday, May 05, 2021 |
| APPL NO | 17/308549 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/246 (20130101) Original (OR) Class Meteorology G01W 1/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405074 | Kaddurah-Daouk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rima F. Kaddurah-Daouk (Belmont, Massachusetts); Jon B. Toledo (Philadelphia, Pennsylvania); Matthias Arnold (Neuherberg, Germany); Gabi Kastemüller (Neuherberg, Germany); Rebecca A. Baillie (San Carlos, California); Xianlin Han (Orlando, Florida); Will Thompson (Durham, North Carolina); Lisa St. John-Williams (Durham, North Carolina); Therese Koal (Innsbruck, Austria); Kwangsik Nho (Indianapolis, Indiana); M. Arthur Moseley (Raleigh, North Carolina); Andrew J. Saykin (Indianapolis, Indiana); Pudugramam Murali Doraiswamy (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rima F. Kaddurah-Daouk (Belmont, Massachusetts); Jon B. Toledo (Philadelphia, Pennsylvania); Matthias Arnold (Neuherberg, Germany); Gabi Kastemüller (Neuherberg, Germany); Rebecca A. Baillie (San Carlos, California); Xianlin Han (Orlando, Florida); Will Thompson (Durham, North Carolina); Lisa St. John-Williams (Durham, North Carolina); Therese Koal (Innsbruck, Austria); Kwangsik Nho (Indianapolis, Indiana); M. Arthur Moseley (Raleigh, North Carolina); Andrew J. Saykin (Indianapolis, Indiana); Pudugramam Murali Doraiswamy (Chapel Hill, North Carolina) |
| ABSTRACT | Embodiments of the present disclosure relate generally to the analysis and identification of global metabolic changes in Alzheimer's disease (AD). More particularly, the present disclosure provides materials and methods relating to the use of metabolomics as a biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to cerebrospinal fluid pathology markers, imaging features, and cognitive performance. Defining metabolic changes during AD disease trajectory and their relationship to clinical phenotypes provides a powerful roadmap for drug and biomarker discovery. |
| FILED | Friday, September 08, 2017 |
| APPL NO | 16/331940 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 2800/50 (20130101) G01N 2800/52 (20130101) G01N 2800/2821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405217 | Henderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xan Henderson (Mesa, Arizona); Michael Marrs (Phoenix, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Xan Henderson (Mesa, Arizona); Michael Marrs (Phoenix, Arizona) |
| ABSTRACT | Some embodiments include an electronic device. The electronic device includes a first scintillator layer, a transistor, and one or more device elements over the transistor, and the one or more device elements include a photodetector. Meanwhile, the first scintillator layer is monolithically integrated with at least one of the transistor or the one or more device elements. Other embodiments of related systems, devices, and methods are also disclosed. |
| FILED | Monday, April 19, 2021 |
| APPL NO | 17/234547 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/4233 (20130101) Measurement of Nuclear or X-radiation G01T 1/2006 (20130101) G01T 1/2018 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14658 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405338 | HUBBARD |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (CAMBRIDGE, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (CAMBRIDGE, Massachusetts) |
| INVENTOR(S) | William HUBBARD (Chester, New Hampshire) |
| ABSTRACT | Disclosed are systems, methods, and structures for broadband phase shifting for quantitative phase microscopy (QPI) that advantageously allows for a greater useable wavelength range for QPI wherein either/both illumination paths and/or scatter paths: 1) propagate through a reflective objective; 2) become quantifiably phase-shifted utilizing broadband mirror surfaces; 3) attenuate the relatively bright illumination paths to maximize contrast; and 4) recombine at a sensor plane for quantitative analysis. |
| FILED | Monday, June 15, 2020 |
| APPL NO | 16/901511 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/14 (20130101) Original (OR) Class G02B 21/0032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405398 | Kolmakov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | German V. Kolmakov (Bellerose, New York); Shaina E. Raklyar (Brooklyn, New York) |
| ABSTRACT | An electro-optical converter that converts an electric signal to an optical signal. An optical signal is dragged from one optical channel to another optical channel using exciton polaritons that are generated in a layer that is adjacent the optical channels. The exciton polaritons are generated in response to an electrical signal which thereby results in the selective production of the optical signal. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 17/355330 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/025 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406214 | PETRINI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fabrizio PETRINI (Menlo Park, California); Kartik LAKHOTIA (Los Angeles, California) |
| ABSTRACT | Methods and apparatus for in-network parallel prefix scan. In one aspect, a dual binary tree topology is embedded in a network to compute prefix scan calculations as data packets traverse the binary tree topology. The dual binary tree topology includes up and down aggregation trees. Input values for a prefix scan are provided at leaves of the up tree. Prefix scan operations such as sum, multiplication, max, etc. are performed at aggregation nodes within the up tree as packets containing associated data propagate from the leaves to the root of the up tree. Output from aggregation nodes in the up tree are provide as input to aggregation nodes in the down tree. In the down tree, the packets containing associated data propagate from the root to its leaves. Output values for the prefix scan are provided at the leaves of the down tree. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/469644 |
| CURRENT CPC | Electric Digital Data Processing G06F 15/17306 (20130101) Original (OR) Class G06F 16/9027 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406414 | Cai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Southern Methodist University (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei Cai (Dallas, Texas); Bo Wang (Dallas, Texas); Wenzhong Zhang (Dallas, Texas) |
| ABSTRACT | Systems and methods for computing interactions of charge sources embedded in three dimensional (3D) layered media. At least one of the methods includes decomposing the Green's function representing the potential caused by a charge source into a free space component and a plurality of reaction components; generating, for each reaction component of the plurality of reaction components, a multipole expansion (ME) operator and a multipole to local (M2L) translation operator; performing, for each reaction component of the plurality of reaction components, a convergence analysis of an ME of that reaction component; defining, for each reaction component, polarization charge sources based on the convergence analysis and combining the polarization charges sources with the charge sources; and computing, using a fast multipole method (FMM), interactions of the charge sources based on the polarization charge sources, the ME operators, and the M2L translation operators. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/341596 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) G06F 30/10 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406602 | Clymer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Clymer (Pittsburgh, Pennsylvania); Jonathan Cagan (Pittsburgh, Pennsylvania); Philip LeDuc (Pittsburgh, Pennsylvania) |
| ABSTRACT | A hierarchical deep-learning object detection framework provides a method for identifying objects of interest in high-resolution, high pixel count images, wherein the objects of interest comprise a relatively a small pixel count when compared to the overall image. The method uses first deep-learning model to analyze the high pixel count images, in whole or as a patchwork, at a lower resolution to identify objects, and a second deep-learning model to analyze the objects at a higher resolution to classify the objects. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/073041 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/00147 (20130101) G06K 9/6247 (20130101) G06K 9/6257 (20130101) Original (OR) Class G06K 9/6277 (20130101) G06K 9/6298 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406660 | Chen |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yong Chen (Encino, California) |
| ABSTRACT | Synaptic resistors (synstors), and their method of manufacture and integration into exemplary circuits are provided. Synstors are configured to emulate the analog signal processing, learning, and memory functions of synapses. Circuits incorporating synstors are capable of performing signal processing and learning concurrently in parallel analog mode with speed, energy efficiency, and functions superior to computers. |
| FILED | Thursday, January 24, 2019 |
| APPL NO | 16/961602 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0635 (20130101) Original (OR) Class Static Stores G11C 11/54 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/47 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406668 | HACK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Universal Display Corporation (Ewing, New Jersey); The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael HACK (Carmel, California); Paul Prucnal (Princeton, New Jersey); Thomas Ferreira de Lima (Princeton, New Jersey); Michael S. WEAVER (Princeton, New Jersey); Simon Bilodeau (Princeton, New Jersey) |
| ABSTRACT | A hybrid neuromorphic computing device is provided, in which artificial neurons include light-emitting devices that provide weighted sums of inputs as light output. The output is detected by a photodetector and converted to an electrical output. Each neuron may receive output from one or more other neurons as initial input. Interconnects between neurons may be optical, electrical, or a combination thereof. The neurons also may provide imaging sensor and/or display capabilities. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/360155 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0635 (20130101) Original (OR) Class G06N 3/0675 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406749 | Oliver et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | William Oliver (Arlington, Massachusetts); Seth Lloyd (Wellesley, Massachusetts); Danna Rosenberg (Arlington, Massachusetts); Michael O'Keeffe (Cambridge, Massachusetts); Amy Greene (Mount Bethel, Pennsylvania); Morten Kjaergaard (Cambridge, Massachusetts); Mollie Schwartz (Cambridge, Massachusetts); Gabriel Samach (Cambridge, Massachusetts); Iman Marvian Mashhad (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for performing open-loop quantum error mitigation using quantum measurement emulations are provided. The open-loop quantum error mitigation methods do not require the performance of state readouts or state tomography, reducing hardware requirements and increasing overall computation speed. To perform a quantum measurement emulation, an error mitigation apparatus is configured to stochastically apply a quantum gate to a qubit or set of qubits during a quantum computational process. The stochastic application of the quantum gate projects the quantum state of the affected qubits onto an axis, reducing a trace distance between the quantum state and a desired quantum state. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/917710 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/004 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/10 (20130101) Coding; Decoding; Code Conversion in General H03M 13/6508 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406757 | KIM et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jungsang KIM (Chapel Hill, North Carolina); Kenneth BROWN (Durham, North Carolina); Christopher MONROE (Ellicott City, Maryland) |
| ABSTRACT | Aspects of the present disclosure describe techniques that involve an active stabilization of coherent controllers using nearby qubits. In an aspect, a quantum information processing (QIP) system for stabilizing phase damping in qubits is described that provides a first and a second qubit ion, measuring magnetic field fluctuations using the second qubit ion, and generates one or more magnetic fields based on the measured magnetic field fluctuations, the one or more magnetic fields being applied near the first qubit ion to cancel the magnetic field fluctuations to stabilize the phase damping of the first qubit ion. Another such QIP system performs provides a first and a second qubit ion, locks a local oscillator to a frequency reference associated with the second qubit ion, and tracks, using the local oscillator, a frequency of the first qubit ion based on the frequency reference. Methods associated with these QIP systems are also described. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362810 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406954 | Kachman et al. |
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| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tal Kachman (Haifa, Israel); Lior Horesh (North Salem, New York); Giacomo Nannicini (New York, New York); Mark S. Squillante (Greenwich, Connecticut); John A. Gunnels (Somers, New York); Kenneth L. Clarkson (Madison, New Jersey) |
| ABSTRACT | A method of detecting cliques in a graph includes determining, based on a number of nodes in the graph, a number of qubits to be included in a quantum processor. The method includes assigning to each node in the graph, a qubit of the quantum processor. The method includes operating on the qubits with a preparation circuit to create a quantum state in the qubits that corresponds to the graph. The method includes operating on the quantum state with a random walk circuit, and measuring the qubits of the quantum processor to detect cliques in the graph. The preparation circuit comprises a plurality of single- and two-qubit operators, wherein, for each pair of adjacent nodes in the graph, an operator of the plurality of two-qubit operators acts on a pair of qubits corresponding to the pair of adjacent nodes to create the quantum state. |
| FILED | Tuesday, September 17, 2019 |
| APPL NO | 16/573862 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0251 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210407758 | Jensen et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Jensen (Washington, District of Columbia); Michael McDonald (Washington, District of Columbia) |
| ABSTRACT | A compound field emitter (CFE) includes a first surface possessing a field enhancement factor >1, and a second surface possessing one or both of a field enhancement factor >1, or a low work function, wherein the second surface is coated, formed or applied upon the first surface. The second surface has a characteristic size at least 3 times smaller than the first surface, and the outer surface includes a coating of calcium aluminate 12CaO-7Al2O3. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353703 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 1/304 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210408923 | Sun et al. |
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| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keyao Sun (Blacksburg, Virginia); Jun Wang (Blacksburg, Virginia); Rolando Burgos (Blacksburg, Virginia); Dushan Boroyevich (Blacksburg, Virginia) |
| ABSTRACT | Aspects of an efficient compensation network for reducing reactive power in a wireless power transfer (WPT) system are disclosed. The compensation network comprises a series/series (S/S) constant current (CC) source, a reactive power compensation capacitor, and a constant current (CC)-to-constant voltage (CV) network. In an example, the S/S CC source comprises a first capacitor connected in series with a first inductor on a primary side of a transformer and a second inductor on a secondary side of the transformer. The S/S CC source converts an input voltage signal of the WPT system into a constant alternating current (AC) current signal. In an example, the CC-to-CV network comprises at least a third capacitor and a third inductor. The CC-to-CV network converts the constant AC current signal into a constant AC voltage signal. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 16/913066 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/12 (20160201) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/126 (20130101) H02M 3/33576 (20130101) Original (OR) Class H02M 7/219 (20130101) H02M 7/5387 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210409049 | Tabrizian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roozbeh Tabrizian (Gainesville, Florida); Troy R. Tharpe (Gainesville, Florida) |
| ABSTRACT | An adaptive filter includes, in part, a linear filter, and a non-linear resonator coupled to the linear filter and adapted to resonate at a frequency that is an integer multiple of the frequency of a received RF signal. The adaptive filter filters out the received RF signal. The resonant frequency may be twice the frequency of the received RF signal. The adaptive filter optionally includes a second non-linear resonator coupled to the linear filter and adapted to resonate at a frequency defined by a sum of the integer multiple of the frequency of the received signal and an offset frequency. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/304993 |
| CURRENT CPC | Transmission H04B 1/123 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210409139 | Sanfelice et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ricardo G. Sanfelice (Santa Cruz, California); Marcello Guarro (Santa Cruz, California) |
| ABSTRACT | A distributed hybrid algorithm that synchronizes the time and rate of a set of clocks connected over a network. Clock measurements of the nodes are given at aperiodic time instants and the controller at each node uses these measurements to achieve synchronization. Due to the continuous and impulsive nature of the clocks and the network, we introduce a hybrid system model to effectively capture the dynamics of the system and the proposed hybrid algorithm. Moreover, the hybrid algorithm allows each agent to estimate the skew of its internal clock in order to allow for synchronization to a common timer rate. We provide sufficient conditions guaranteeing synchronization of the timers, exponentially fast. Numerical results illustrate the synchronization property induced by the algorithm as well as its performance against comparable algorithms from the literature. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361913 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/14 (20130101) G06F 17/16 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Multiplex Communication H04J 3/067 (20130101) H04J 3/0667 (20130101) Original (OR) Class H04J 3/1664 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210409265 | PAWLOWSKI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert PAWLOWSKI (Beaverton, Oregon); Vincent CAVE (Hillsboro, Oregon); Shruti SHARMA (Hillsboro, Oregon); Fabrizio PETRINI (Menlo Park, California); Joshua B. FRYMAN (Corvallis, Oregon); Ankit MORE (San Mateo, California) |
| ABSTRACT | Examples described herein relate to a first group of core nodes to couple with a group of switch nodes and a second group of core nodes to couple with the group of switch nodes, wherein: a core node of the first or second group of core nodes includes circuitry to execute one or more message passing instructions that indicate a configuration of a network to transmit data toward two or more endpoint core nodes and a switch node of the group of switch nodes includes circuitry to execute one or more message passing instructions that indicate the configuration to transmit data toward the two or more endpoint core nodes. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473540 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/0803 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210409902 | Borel-Donohue |
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| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christoph C. Borel-Donohue (Silver Spring, Maryland) |
| ABSTRACT | Methods, systems, and computer code on computer-readable media are provided that are directed to generating area skyline data using a digital elevation or surface models (DEMs or DESs) and shadow casting techniques. Some embodiments use an area of maximum shadow line overlap, for shadow line images based on target location skyline azimuth and elevation angle data, as the best approximation for the position of the target location in an area. Some embodiments select the location showing the best fit to the target skyline azimuth and elevation angle data as the best approximation for the target location. |
| FILED | Monday, June 29, 2020 |
| APPL NO | 16/916025 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3602 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00704 (20130101) Image Data Processing or Generation, in General G06T 7/75 (20170101) G06T 15/60 (20130101) G06T 2207/30244 (20130101) G06T 2215/12 (20130101) Wireless Communication Networks H04W 4/029 (20180201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210410263 | Miles et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Richard B. Miles (College Station, Texas); Christopher Limbach (College Station, Texas); Alexandros Gerakis (Voula, Greece) |
| ABSTRACT | An apparatus for measurement of Thomson scattering signals from a plasma includes a light emitting device, configured to emit a light beam into the plasma, along an axis. In addition, the apparatus includes a collector configured to collect the Thomson scattering from the plasma at an angle less than 90 degrees from the axis of the light beam. Further, the apparatus includes a sensor assembly to detect the Thomson scattering. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/353994 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/0018 (20130101) H05H 1/0037 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20210401376 | ROVEDA et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS OF THE UNIVERSITY OF ARIZONA, A BODY CORPORATE (TUCSON, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JANET ROVEDA (TUCSON, Arizona); SITENG CHEN (TUCSON, Arizona); AO LI (TUCSON, Arizona); STUART QUAN (TUCSON, Arizona); LINDA POWERS (TUCSON, Arizona) |
| ABSTRACT | Systems and methods detect cortical arousal events from a single time-varying ECG signal that is obtained via single-lead ECG. A pre-trained deep neural network transforms the ECG signal into a sequence of cortical-arousal probabilities. The deep neural network includes an inception module, a residual neural network, and a long short-term memory neural network to identify structure in the ECG signal that distinguishes periods of cortical arousal from periods without cortical arousal. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/363933 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/346 (20210101) A61B 5/7264 (20130101) Original (OR) Class A61B 5/7285 (20130101) Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) G06N 3/0445 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402061 | Reddy et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sashank Reddy (Baltimore, Maryland); Russell Martin (Baltimore, Maryland); Xiaowei Li (Towson, Maryland); Calvin Chang (Baltimore, Maryland); Kevin Colbert (Baltimore, Maryland); Hai-Quan Mao (Baltimore, Maryland) |
| ABSTRACT | A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel. |
| FILED | Thursday, May 09, 2019 |
| APPL NO | 17/054156 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/48 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 27/3808 (20130101) A61L 27/3834 (20130101) Original (OR) Class A61L 27/3895 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402064 | Martin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell Martin (Baltimore, Maryland); Sashank Reddy (Baltimore, Maryland); Kevin Colbert (Baltimore, Maryland); Hai-Quan Mao (Baltimore, Maryland) |
| ABSTRACT | A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel. |
| FILED | Thursday, May 09, 2019 |
| APPL NO | 17/054161 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/48 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/3633 (20130101) A61L 2300/62 (20130101) A61L 2300/236 (20130101) A61L 2400/06 (20130101) A61L 2430/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402380 | YAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | San Diego State University Foundation (San Diego, California) |
| ASSIGNEE(S) | San Diego State University Foundation (San Diego, California) |
| INVENTOR(S) | Yong YAN (San Diego, California) |
| ABSTRACT | Nature is capable of storing solar energy in chemical bonds via photosynthesis through a series of C—C, C—O and C—N bond-forming reactions starting from CO2 and light. Direct capture of solar energy for organic synthesis is a promising approach. Lead (Pb)-halide perovskite solar cells reach 24.2% power conversion efficiency, rendering perovskite a unique type material for solar energy capture. We show that photophysical properties of perovskites is useful in photoredox organic synthesis. Because the key aspects of these two applications are both relying on charge separation and transfer. Here we demonstrated that perovskites nanocrystals are exceptional candidates as photocatalysts for fundamental organic reactions, i.e. C—C, C—N and C—O bond-formations. Stability of CsPbBr3 in organic solvents and ease-of-tuning their bandedges garner perovskite a wider scope of organic substrate activations. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/350431 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/123 (20130101) B01J 19/127 (20130101) B01J 27/128 (20130101) B01J 27/135 (20130101) Original (OR) Class B01J 31/30 (20130101) B01J 31/127 (20130101) B01J 35/004 (20130101) B01J 35/0006 (20130101) B01J 35/0013 (20130101) B01J 35/026 (20130101) B01J 2219/0892 (20130101) B01J 2219/1203 (20130101) B01J 2231/46 (20130101) B01J 2231/49 (20130101) B01J 2231/326 (20130101) B01J 2231/4277 (20130101) B01J 2531/007 (20130101) Acyclic or Carbocyclic Compounds C07C 45/72 (20130101) C07C 67/10 (20130101) C07C 2601/16 (20170501) Heterocyclic Compounds C07D 207/34 (20130101) C07D 211/90 (20130101) C07D 211/94 (20130101) C07D 217/12 (20130101) C07D 217/16 (20130101) C07D 231/12 (20130101) C07D 405/04 (20130101) C07D 413/12 (20130101) C07D 498/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402668 | HATZELL et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelsey B. HATZELL (Nashville, Tennessee); Marta C. HATZELL (Atlanta, Georgia); Marm B. Dixit (Nashville, Tennessee) |
| ABSTRACT | Various implementations include a coextrusion device including a first shim plate and a second shim plate coupled to the first shim plate. The first and second shim plates each have a first side, a second side opposite and spaced apart from the first side, a first end, and a second end opposite and spaced apart from the first end. The second end defines one or more outlet openings. A flow channel extends from each of the one or more outlet openings and extends along a centralized axis from the second end toward the first end. A central plane extends perpendicular to the first side and along each of the centralized axes of each shim plate. The central planes of the first and second shim plates intersect an axis perpendicular to the central planes and are spaced apart from each other. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 17/279260 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/08 (20190201) B29C 48/18 (20190201) B29C 48/705 (20190201) Original (OR) Class Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/3468 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402678 | You et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shangting You (La Jolla, California); Shaochen CHEN (San Diego, California) |
| ABSTRACT | A method and system for microscale 3D printing achieve high-fidelity fabrication through the control of the light exposure time. A single pulse of light is used to initiate polymerization of a pre-polymer solution to minimize scattering-induced resolution deterioration. The printed object is fabricated in a layer-by-layer construction where each layer is formed through exposure to a single light pulse. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/360891 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) Original (OR) Class B29C 64/232 (20170801) B29C 64/245 (20170801) B29C 64/273 (20170801) B29C 64/286 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402701 | Vidimce et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kiril Vidimce (Cambridge, Massachusetts); Ye Wang (San Francisco, California); Wojciech Matusik (Lexington, Massachusetts) |
| ABSTRACT | According to some aspects, a method of designing a three-dimensional object based on a shape of the object, the object to be fabricated via additive fabrication from a plurality of materials, is provided. The method comprises selecting, for a first volume element of the object, one of the plurality of materials based at least in part on a position of the first volume element within the object, at least one spatial decomposition of the object, the at least one spatial decomposition identifying a plurality of volumetric subregions of the object, and a material composition of at least a first volumetric subregion of the plurality of volumetric subregions, wherein the first volumetric subregion comprises the position of the first volume element. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208261 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/386 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2055/02 (20130101) Electric Digital Data Processing G06F 30/00 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403340 | Weller et al. |
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| FUNDED BY |
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| APPLICANT(S) | Jon Mark Weller (Phoenix, Arizona); Candace Chan (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jon Mark Weller (Phoenix, Arizona); Candace Chan (Phoenix, Arizona) |
| ABSTRACT | Synthesizing lithium lanthanum zirconate includes combining a reagent composition with a salt composition to yield a molten salt reaction medium, wherein the reagent composition comprises a lithium component, a lanthanum component, and zirconium component having a lithium:lanthanum:zirconium molar ratio of about 7:3:2; heating the molten salt reaction medium to yield a reaction product; and washing the reaction product to yield a crystalline powder comprising lithium lanthanum zirconate. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/366990 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 25/006 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/74 (20130101) C01P 2002/76 (20130101) C01P 2002/85 (20130101) C01P 2004/04 (20130101) C01P 2004/51 (20130101) C01P 2004/62 (20130101) C01P 2004/64 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 2300/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403378 | Balapour et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Mohammad Balapour (Phladelphia, Pennsylvania); Yaghoob Farnam (Philadelphia, Pennsylvania); Yick Grace Hsuan (Ardmore, Pennsylvania) |
| ABSTRACT | Manufacturing lightweight aggregate (LWA) by a sintering technique requires a delicate balance among three conditions: forming sufficient amount of molten liquid phase during sintering; reaching an appropriate viscosity for solid-liquid suspension; and emitting sufficient amount of gas that can be entrapped by the liquid phase to form pores. LWAs were made from low-calcium and high-calcium Waste Coal Combustion Ash (W-CCA) including fly ash and bottom ash. A mass fraction of at least 40% liquid phase for fly ash and 50% for bottom ash is required for a successful entrapment of emitted gaseous phases during sintering. Larger pores were observed in the microstructure of LWA samples made using high-calcium W-CCA in comparison to low-calcium W-CCA. This result was mainly attributed to the high-calcium samples forming liquid phases with lower viscosity values and emitting higher amounts of gaseous phase during sintering than did the low-calcium samples. The gaseous phase was generated by hematite reduction and anhydrite decomposition. |
| FILED | Thursday, September 09, 2021 |
| APPL NO | 17/469945 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 18/027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403499 | Pemberton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| INVENTOR(S) | Jeanne E. Pemberton (Tucson, Arizona); Robin L. Polt (Tucson, Arizona); Raina M. Maier (Tucson, Arizona); Ricardo Palos Pacheco (Tucson, Arizona) |
| ABSTRACT | The present invention provides carbohydrate-based surfactants and methods for producing the same. Methods for producing carbohydrate-based surfactants include using a glycosylation promoter to link a carbohydrate or its derivative to a hydrophobic compound. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473999 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 3/003 (20130101) C07F 9/94 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 15/04 (20130101) C07H 15/06 (20130101) C07H 15/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403739 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanliang Zhang (South Bend, Indiana); Minxiang Zeng (South Bend, Indiana) |
| ABSTRACT | Provided are an ink composition, comprising greater than 0.2% by weight a graphene quantum dot nanosurfactant, a printable material, and a solvent, wherein the printable material is dispersed in the solvent by the graphene quantum dot nanosurfactant, and a method of preparing an ink composition. Advantageously, the present ink composition may be printed onto 2D and 3D substrates to form printed films with improved mechanical stability and photoconductance. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357805 |
| CURRENT CPC | Printing, Duplicating, Marking, or Copying Processes; Colour Printing, B41M 5/0023 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/033 (20130101) C09D 11/037 (20130101) C09D 11/38 (20130101) Original (OR) Class C09D 11/52 (20130101) C09D 11/322 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403926 | Beisel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chase Lawrence Beisel (Raleigh, North Carolina); Ahmed Abdelshafy Mahmoud Gomaa (Raleigh, North Carolina); Michelle Luo (Raleigh, North Carolina) |
| ABSTRACT | The invention relates to the methods for modifying the methylation pattern of bacteriophage DNA and phagemid DNA and to methods for selective killing of bacteria using lysogenic bacteriophages comprising bacteriophage DNA or phagemid DNA comprising components of an engineered CRISPR-Cas system. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/471776 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/40 (20200101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 9/1007 (20130101) C12N 15/11 (20130101) C12N 15/70 (20130101) Original (OR) Class C12N 15/102 (20130101) C12N 2310/20 (20170501) C12N 2795/10143 (20130101) C12N 2795/14143 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404071 | Choi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyoung-Shin Choi (Fitchburg, Wisconsin); Stephen Riley Kubota (Madison, Wisconsin) |
| ABSTRACT | Methods for electrochemically oxidizing aromatic aldehydes, such as furfural and furfural derivatives, to carboxylic acids in acidic solutions are provided. Also provided are electrochemical cells for carrying out the oxidation reactions. The electrochemical oxidations may be conducted in aqueous media at ambient pressure and mild temperatures. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474286 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/23 (20210101) Original (OR) Class C25B 11/04 (20130101) C25B 11/054 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404333 | Knight et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Biota Technology, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rob Knight (San Diego, California); Ajay Kshatriya (Oakland, California); John Ely (Houston, Texas); Paul Henshaw (Clayton, California); J. Gregory Caporaso (Flagstaff, Arizona); Dan Knights (St. Paul, Minnesota); Ryan Gill (Denver, Colorado) |
| ABSTRACT | There are provided methods, systems and processes for the utilization of microbial and related genetic information for use in the exploration, determination, production and recovery of natural resources, including energy sources, and the monitoring, control and analysis of processes and activities. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196480 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/62 (20130101) C09K 8/582 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6874 (20130101) C12Q 1/6888 (20130101) C12Q 2600/156 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/00 (20130101) E21B 43/26 (20130101) E21B 47/11 (20200501) E21B 49/00 (20130101) E21B 49/08 (20130101) Original (OR) Class E21B 49/086 (20130101) E21B 49/0875 (20200501) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 9/00 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 10/00 (20190201) G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 40/00 (20190201) G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404917 | Mayerich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | David Mayerich (Houston, Texas); Jason Eriksen (Houston, Texas) |
| ABSTRACT | Milling with ultraviolet excitation (MUVE) realizes high-throughput multiplex imaging of large three-dimensional samples. The instrumentation may comprise a UV-source attachment, precision stage attachment, and/or a blade assembly, and the instrumentation may overcome several constraints inherent to current state-of-the-art three-dimensional microscopy. MUVE offers throughput that is orders of magnitude faster than other technology by collecting a two-dimensional array of pixels simultaneously. The proposed instrumentation also utilizes serial ablation and provides the opportunity for true whole-organ imaging at microscopic resolution. |
| FILED | Friday, November 15, 2019 |
| APPL NO | 17/294489 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 1/36 (20130101) G01N 1/286 (20130101) G01N 21/6458 (20130101) G01N 2001/302 (20130101) G01N 2001/364 (20130101) G01N 2001/2873 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404937 | SARIOGLU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali Fatih SARIOGLU (Atlanta, Georgia); Ningquan WANG (Atlanta, Georgia) |
| ABSTRACT | A microfluidic device for particle analysis, such as immunophenotyping, includes a plurality of microfluidic channels for the passage of a particle-laden fluid flow, a plurality of dedicated impedance sensors for generating impedance signals relative to each microfluidic sensor. The impedance sensors are CODES Coulter sensors, each having a distinct coded sequence for generating mutually orthogonal signals. The system uses a multi-frequency excitation signal for driving the Coulter sensors, such that the Coulter sensors generate multi-frequency impedance signals. The system outputs the multi-frequency signals of the plurality of impedance sensors as a single multi-frequency multiplexed signal, which is subsequently separated into a plurality of single-frequency multiplexed signals, which are then demodulated into single-frequency component signals corresponding to each of the Coulter sensors. |
| FILED | Monday, November 11, 2019 |
| APPL NO | 17/292273 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1056 (20130101) Original (OR) Class G01N 15/1404 (20130101) G01N 2015/1037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405003 | Dasgupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Purnendu K. Dasgupta (Arlington, Texas); Akinde F. Kadjo (Arlington, Texas); Charles Phillip Shelor (Arlington, Texas) |
| ABSTRACT | A method of converting longer path cell signal data to shorter path cell signal data comprising: obtaining a longer path absorbance signal tracing and a shorter path absorbance signal tracing for at least one analyte band under the same conditions; obtaining an approximate superimposable match between the longer path absorbance signal tracing and the shorter path absorbance signal tracing using an amplitude scaling factor and one or more parameters derived from a dispersion model that accounts for dispersion differences between a short cell and a long cell; and applying the dispersion model in reverse using the derived parameters to future longer path absorbance signal traces from the longer path cell signal data to generate the shorter path cell signal data. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226813 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/8617 (20130101) G01N 30/8624 (20130101) G01N 30/8693 (20130101) Original (OR) Class G01N 2030/8648 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405064 | Mei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Clemson University Research Foundation (Clemson, South Carolina); MUSC Foundation for Research Development (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ying Mei (Mount Pleasant, South Carolina); Jia Jia (Charleston, South Carolina); Chung-Jen James Chou (Mount Pleasant, South Carolina) |
| ABSTRACT | The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation and is useful for bioprinting. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 17/476971 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/52 (20130101) C07K 14/71 (20130101) C07K 14/75 (20130101) C07K 14/78 (20130101) C07K 14/755 (20130101) C07K 14/70546 (20130101) C07K 17/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/74 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2333/70557 (20130101) G01N 2500/04 (20130101) G01N 2500/20 (20130101) G01N 2800/7014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405207 | STILLWELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY CORPORATION FOR ATMOSPHERIC RESEARCH (Boulder, Colorado); MONTANA STATE UNIVERSITY (Bozeman, Montana) |
| ASSIGNEE(S) | UNIVERSITY CORPORATION FOR ATMOSPHERIC RESEARCH (Boulder, Colorado); MONTANA STATE UNIVERSITY (Bozeman, Montana) |
| INVENTOR(S) | Robert STILLWELL (Broomfield, Colorado); Scott SPULER (Westminster, Colorado); Matthew HAYMAN (Boulder, Colorado); Kevin S. REPASKY (Bozeman, Montana) |
| ABSTRACT | A beam transmitter, a receiver, and a LIDAR, along with methods to operate each are provided. The beam transmitter comprises a first and a second transmission channel (201a, 201b), each transmission channel including a first online laser, a first offline laser, and a first laser transmission selection switch operable to toggle between including the first online laser signal and the first offline laser signal in a first transmission beam. The beam transmitter further includes at least one light redirection device operable to coalign the first transmission beam with the second transmission beam. The receiver comprises a first splitter (402a, 402b), a first filter (404a, 404b), a first detector channel (406a, 406b), a second splitter (408a, 408b), a second filter (410a, 410b), and a second detector channel (412a, 412b). The LIDAR includes the beam transmitter, the receiver, and a shared telescope. |
| FILED | Friday, November 30, 2018 |
| APPL NO | 17/294673 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/484 (20130101) G01S 7/4815 (20130101) G01S 17/86 (20200101) G01S 17/95 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405257 | YI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ya Sha YI (Troy, Michigan); Mao YE (Dearborn, Michigan) |
| ABSTRACT | A metalens configured to shape the focus light into a flexibly designed pattern. The present teachings demonstrate the engineering of metalens with artificial focus pattern by creating line and ring-shaped focus as ‘drawing tools’. These metalens are fabricated through a single layer of silicon-based material through CMOS compatible nano fabrication process. The mechanism to generate artificial focus pattern can be applied to a plethora of future on-chip optical devices with applications ranging from beam engineering to next generation nano lithography. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357076 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class G02B 27/42 (20130101) G02B 2207/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405318 | Monroe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | James Alan Monroe (College Station, Texas); David Scott Content (Spring, Texas); Jeremy Sean McAllister (Bryan, Texas); Jay Russell Zgarba (Sugar Land, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Alan Monroe (College Station, Texas); David Scott Content (Spring, Texas); Jeremy Sean McAllister (Bryan, Texas); Jay Russell Zgarba (Sugar Land, Texas) |
| ABSTRACT | A lens alignment system and method is disclosed. The disclosed system/method integrates one or more lens retaining members/tubes (LRM/LRT) and focal length spacers (FLS) each comprising a metallic material product (MMP) specifically manufactured to have a thermal expansion coefficient (TEC) in a predetermined range via selection of the individual MMP materials and an associated MMP manufacturing process providing for controlled TEC. This controlled LRM/LRT TEC enables a plurality of optical lenses (POL) fixed along a common optical axis (COA) by the LRM/LRT to maintain precise interspatial alignment characteristics that ensure consistent and/or controlled series focal length (SFL) within the POL to generate a thermally neutral optical system (TNOS). Integration of the POL using this LRM/LRT/FLS lens alignment system reduces the overall TNOS implementation cost, reduces the overall TNOS mass, reduces TNOS parts component count, and increases the reliability of the overall optical system. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/467738 |
| CURRENT CPC | Alloys C22C 14/00 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/183 (20130101) Optical Elements, Systems, or Apparatus G02B 7/003 (20130101) G02B 7/028 (20130101) Original (OR) Class G02B 23/2407 (20130101) G02B 27/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405319 | Monroe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | James Alan Monroe (College Station, Texas); David Scott Content (Spring, Texas); Jeremy Sean McAllister (Bryan, Texas); Jay Russell Zgarba (Sugar Land, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Alan Monroe (College Station, Texas); David Scott Content (Spring, Texas); Jeremy Sean McAllister (Bryan, Texas); Jay Russell Zgarba (Sugar Land, Texas) |
| ABSTRACT | A lens alignment system and method is disclosed. The disclosed system/method integrates one or more lens retaining members/tubes (LRM/LRT) and focal length spacers (FLS) each comprising a metallic material product (MMP) specifically manufactured to have a thermal expansion coefficient (TEC) in a predetermined range via selection of the individual MMP materials and an associated MMP manufacturing process providing for controlled TEC. This controlled LRM/LRT TEC enables a plurality of optical lenses (POL) fixed along a common optical axis (COA) by the LRM/LRT to maintain precise interspatial alignment characteristics that ensure consistent and/or controlled series focal length (SFL) within the POL to generate a thermally neutral optical system (TNOS). Integration of the POL using this LRM/LRT/FLS lens alignment system reduces the overall TNOS implementation cost, reduces the overall TNOS mass, reduces TNOS parts component count, and increases the reliability of the overall optical system. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/467753 |
| CURRENT CPC | Alloys C22C 14/00 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/183 (20130101) Optical Elements, Systems, or Apparatus G02B 7/003 (20130101) G02B 7/028 (20130101) Original (OR) Class G02B 23/2407 (20130101) G02B 27/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405659 | Chowdhary et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Girish Chowdhary (Champaign, Illinois); Girish Joshi (Redmond, Washington); Jasvir Virdi (Urbana, Illinois) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, determining, at a slower time-scale, inner layer weights of an inner layer of a deep neural network; providing periodically to an outer layer of the deep neural network from the inner layer, a feature vector based upon the inner layer weights; and determining, at a faster time-scale, outer layer weights of the outer layer, wherein the outer layer weights are determined in accordance with a Model Reference Adaptive Control (MRAC) update law that is based upon the feature vector from the inner layer, and wherein the outer layer weights are determined more frequently than the inner layer weights. Other embodiments are disclosed. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354912 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) G05D 1/101 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406414 | Cai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Southern Methodist University (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wei Cai (Dallas, Texas); Bo Wang (Dallas, Texas); Wenzhong Zhang (Dallas, Texas) |
| ABSTRACT | Systems and methods for computing interactions of charge sources embedded in three dimensional (3D) layered media. At least one of the methods includes decomposing the Green's function representing the potential caused by a charge source into a free space component and a plurality of reaction components; generating, for each reaction component of the plurality of reaction components, a multipole expansion (ME) operator and a multipole to local (M2L) translation operator; performing, for each reaction component of the plurality of reaction components, a convergence analysis of an ME of that reaction component; defining, for each reaction component, polarization charge sources based on the convergence analysis and combining the polarization charges sources with the charge sources; and computing, using a fast multipole method (FMM), interactions of the charge sources based on the polarization charge sources, the ME operators, and the M2L translation operators. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/341596 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) G06F 30/10 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406528 | Ramani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karthik Ramani (West Lafayette, Indiana); Tianyi Wang (West Lafayette, Indiana); Xun Qian (West Lafayette, Indiana) |
| ABSTRACT | A system and method for authoring and implementing context-aware applications (CAPs) are disclosed. The system and method enables users to record their daily activities and then build and deploy customized CAPs onto augmented reality platforms in which automated actions are performed in response to user-defined human actions. The system and method utilizes an integrated augmented reality platform composed of multiple camera systems, which allows for non-intrusive recording of end-users' activities and context detection while authoring and implementing CAPs. The system and method provides an augmented reality authoring interface for browsing, selecting, and editing recorded activities, and creating flexible CAPs through spatial interaction and visual programming. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/363365 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/011 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00342 (20130101) G06K 9/00355 (20130101) Original (OR) Class G06K 9/00369 (20130101) G06K 9/00671 (20130101) Image Data Processing or Generation, in General G06T 7/215 (20170101) G06T 13/40 (20130101) G06T 19/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406648 | Lathrop et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Lathrop (University Park, Maryland); Itamar Shani (Rockville, Maryland); Peter Megson (Washington, District of Columbia); Alessandro Restelli (Greenbelt, Maryland); Anthony Robert Mautino (Damascus, Maryland) |
| ABSTRACT | An integrated circuit device for reservoir computing can include a weighted input layer, an unweighted, asynchronous, internal recurrent neural network made up of nodes having binary weighting, and a weighted output layer. Weighting of output signals can be performed using predetermined weighted sums stored in memory. Application specific integrated circuit (ASIC) embodiments may include programmable nodes. Characteristics of the reservoir of the device can be tunable to perform rapid processing and pattern recognition of signals at relatively large rates. |
| FILED | Wednesday, May 16, 2018 |
| APPL NO | 16/613990 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/063 (20130101) Original (OR) Class G06N 3/0445 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210407782 | Jarrold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. Jarrold (Bloomington, Oregon); Andrew W. Alexander (Bloomington, Indiana); Aaron R. Todd (Bloomington, Indiana) |
| ABSTRACT | A CDMS may include an ELIT having a charge detection cylinder (CD), a charge generator for generating a high frequency charge (HFC), a charge sensitive preamplifier (CP) having an input coupled to the CD and an output configured to produce a charge detection signal (CHD) in response to a charge induced on the CD, and a processor configured to (a) control the charge generator to induce an HFC on the CD, (b) control operation of the ELIT to cause a trapped ion to oscillate back and forth through the CD each time inducing a charge thereon, and (c) process CHD to (i) determine a gain factor as a function of the HFC induced on the CD, and (ii) modify a magnitude of the portion of CHD resulting from the charge induced on the CD by the trapped ion passing therethrough as a function of the gain factor. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/468841 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0009 (20130101) H01J 49/022 (20130101) H01J 49/025 (20130101) Original (OR) Class H01J 49/4245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210407785 | Jarrold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. Jarrold (Bloomington, Oregon); Staci N. Anthony (Grandview, Ohio); Benjamin E. Draper (Bloomington, Indiana) |
| ABSTRACT | An instrument for separating ions may include an ion source in a first pressure environment at a first pressure and configured to generate ions from a sample, an ion separation instrument, controlled to an instrument pressure that is less than the first pressure, and configured to separate ions as a function of at least one molecular characteristic and an interface, controlled to a second pressure less than the first pressure and greater than the instrument pressure, for transporting the generated ions from the first pressure environment into the ion separation instrument operating at the instrument pressure. The interface may include a sealed ion funnel defining an axial passageway therethrough, and an ion carpet sealed to the first ion funnel. A portion of the axial passageway tapers from a first cross-sectional area to a reduced cross-sectional area such that the tapered axial passageway defining a virtual jet disrupter therein. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/468738 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/022 (20130101) H01J 49/24 (20130101) H01J 49/025 (20130101) H01J 49/066 (20130101) Original (OR) Class H01J 49/425 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210407787 | Jarrold et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. Jarrold (Bloomington, Oregon); Joanna A. Hogan (Hillsboro, Oregon) |
| ABSTRACT | An instrument for separating ions may include an ion source configured to generate ions from a sample, at least one ion separation instrument configured to separate the generated ions as a function of at least one molecular characteristic and an electrostatic linear ion trap (ELIT) positioned to receive ions exiting the at least one ion separation instrument. The ELIT has first and second ion mirrors separated by a charge detection cylinder, and is configured such that an ion trapped therein oscillates back and forth through the charge detection cylinder between the first and second ion mirrors with a duty cycle, corresponding to a ratio of time spent by the trapped ion traversing the charge detection cylinder and total time spent by the trapped ion traversing a combination of the first and second ion mirrors and the charge detection cylinder during one complete oscillation cycle, of approximately 50%. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/468791 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/025 (20130101) H01J 49/0036 (20130101) H01J 49/062 (20130101) H01J 49/406 (20130101) H01J 49/4235 (20130101) H01J 49/4245 (20130101) Original (OR) Class H01J 49/4265 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210407820 | Ahmed et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| INVENTOR(S) | Omar Saad Ahmed (Orlando, Florida); Tengfei Jiang (Orlando, Florida) |
| ABSTRACT | A method for isolating at least one conductive via from a surrounding glass substrate is provided. A support layer is formed over at least one surface of the glass substrate. Thereafter, the glass substrate is removed. As a result, the at least one conductive via can be analyzed without interference from the glass substrate. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333373 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 15/00 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/486 (20130101) Original (OR) Class H01L 21/4864 (20130101) H01L 22/32 (20130101) H01L 23/15 (20130101) H01L 23/49827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210408272 | Li et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huamin Li (Buffalo, New York); Fei Yao (Buffalo, New York) |
| ABSTRACT | Field effect transistors (FET) including quantum layers. A FET may include a substrate, and an oxide layer disposed over the substrate. The oxide layer may include a first section and a second section positioned adjacent the first section. The FET may also include a first quantum layer disposed over the first section of the oxide layer, and a second quantum layer disposed over the second section of the oxide layer, and a first segment of the first quantum layer. Additionally, the FET may include a drain region disposed directly over a second segment the first quantum layer. The second segment of the first quantum layer may be positioned adjacent the first segment of the first quantum layer. The FET may further include a source region disposed over the second quantum layer, and a channel region formed over the second quantum layer, between the drain region and the source region. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358500 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/775 (20130101) Original (OR) Class H01L 29/41733 (20130101) H01L 29/42384 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210408325 | KIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Seok KIM (Champaign, Illinois); Moonsub SHIM (Savoy, Illinois); Jun Kyu PARK (Champaign, Illinois); Hohyun KEUM (Champaign, Illinois); Yiran JIANG (Freemont, California) |
| ABSTRACT | The present disclosure describes one or more embodiment of a method for creating a patterned quantum dot layer. The method includes bringing a patterning stamp in contact with a layer of quantum dots disposed on a substrate, the patterning stamp comprising a patterned photoresist layer disposed on an elastomer layer, such that a portion of the quantum dots in contact with the patterned photoresist layer adheres to the patterning stamp, the portion of the quantum dots being adhered quantum dots. The method also includes peeling the patterning stamp from the substrate with a peeling speed larger than a pre-determined peeling speed to remove the adhered quantum dots from the substrate. A remaining portion of the quantum dots forms a patterned quantum dot layer on the substrate. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474332 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) Original (OR) Class H01L 33/505 (20130101) H01L 33/507 (20130101) H01L 2933/0041 (20130101) H01L 2933/0058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210408369 | Liu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Kai Liu (Falls Church, Virginia) |
| ABSTRACT | Utilizing the topological character of patterns in 3D structures is beneficial for information storage, magnetic memory and logic systems. One embodiment describes the use of topological knots, exemplified by a Möbius strip, in which a spin traversing along the band for a complete cycle will recover its original position, while having rotated away from its original orientation. The spins can respond to an external magnetic field, but cannot achieve a ferromagnetic state, in which all magnetic moments are pointing in the same direction, due to the topological knot. 3D assemblies of such nano-Möbius strips may form prototype secure magnetic information storage devices that are secure and with extremely low levels of energy dissipation. |
| FILED | Thursday, September 09, 2021 |
| APPL NO | 17/470856 |
| CURRENT CPC | Static Stores G11C 11/161 (20130101) G11C 11/1673 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/222 (20130101) H01L 43/02 (20130101) Original (OR) Class H01L 43/10 (20130101) H01L 43/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210408539 | Zhu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts); Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongli Zhu (Arlington, Massachusetts); Yubin Zhang (Worcester, Massachusetts); Yan Wang (Shrewsbury, Massachusetts); Daxian Cao (Boston, Massachusetts) |
| ABSTRACT | A solid-state battery is described. The solid-state battery includes an anode, a coated cathode, and an electrolyte. The cathode coating is formed of lithium (Li), lanthanum (La), strontium (Sr), titanium (Ti), and oxygen (O). The cathode coating has a high ionic conductivity. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/363693 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0457 (20130101) H01M 4/0471 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 10/0562 (20130101) H01M 2300/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210409139 | Sanfelice et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ricardo G. Sanfelice (Santa Cruz, California); Marcello Guarro (Santa Cruz, California) |
| ABSTRACT | A distributed hybrid algorithm that synchronizes the time and rate of a set of clocks connected over a network. Clock measurements of the nodes are given at aperiodic time instants and the controller at each node uses these measurements to achieve synchronization. Due to the continuous and impulsive nature of the clocks and the network, we introduce a hybrid system model to effectively capture the dynamics of the system and the proposed hybrid algorithm. Moreover, the hybrid algorithm allows each agent to estimate the skew of its internal clock in order to allow for synchronization to a common timer rate. We provide sufficient conditions guaranteeing synchronization of the timers, exponentially fast. Numerical results illustrate the synchronization property induced by the algorithm as well as its performance against comparable algorithms from the literature. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361913 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/14 (20130101) G06F 17/16 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Multiplex Communication H04J 3/067 (20130101) H04J 3/0667 (20130101) Original (OR) Class H04J 3/1664 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210410283 | Bottiglio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca Bottiglio (Hamden, Connecticut); Shanliangzi Liu (New Haven, Connecticut); Dylan Shah (New Haven, Connecticut); Lina Mercedes Sanchez Botero (New Haven, Connecticut) |
| ABSTRACT | A biphasic composition comprises a quantity of liquid GaIn and a plurality of solid particles of Ga2O3 suspended in the quantity of liquid GaIn, the Ga2O3 particles having a median particle size between 8 μm and 25 μm, wherein the volumetric ratio of solid particles of Ga2O3 to liquid GaIn is between 0.4 and 0.7. A method of making a biphasic composition of GaIn, a method of making a stretchable circuit board assembly, and a stretchable circuit board assembly are also described. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357060 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0283 (20130101) H05K 1/0393 (20130101) Original (OR) Class H05K 3/4635 (20130101) H05K 2201/0233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20210402380 | YAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | San Diego State University Foundation (San Diego, California) |
| ASSIGNEE(S) | San Diego State University Foundation (San Diego, California) |
| INVENTOR(S) | Yong YAN (San Diego, California) |
| ABSTRACT | Nature is capable of storing solar energy in chemical bonds via photosynthesis through a series of C—C, C—O and C—N bond-forming reactions starting from CO2 and light. Direct capture of solar energy for organic synthesis is a promising approach. Lead (Pb)-halide perovskite solar cells reach 24.2% power conversion efficiency, rendering perovskite a unique type material for solar energy capture. We show that photophysical properties of perovskites is useful in photoredox organic synthesis. Because the key aspects of these two applications are both relying on charge separation and transfer. Here we demonstrated that perovskites nanocrystals are exceptional candidates as photocatalysts for fundamental organic reactions, i.e. C—C, C—N and C—O bond-formations. Stability of CsPbBr3 in organic solvents and ease-of-tuning their bandedges garner perovskite a wider scope of organic substrate activations. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/350431 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/123 (20130101) B01J 19/127 (20130101) B01J 27/128 (20130101) B01J 27/135 (20130101) Original (OR) Class B01J 31/30 (20130101) B01J 31/127 (20130101) B01J 35/004 (20130101) B01J 35/0006 (20130101) B01J 35/0013 (20130101) B01J 35/026 (20130101) B01J 2219/0892 (20130101) B01J 2219/1203 (20130101) B01J 2231/46 (20130101) B01J 2231/49 (20130101) B01J 2231/326 (20130101) B01J 2231/4277 (20130101) B01J 2531/007 (20130101) Acyclic or Carbocyclic Compounds C07C 45/72 (20130101) C07C 67/10 (20130101) C07C 2601/16 (20170501) Heterocyclic Compounds C07D 207/34 (20130101) C07D 211/90 (20130101) C07D 211/94 (20130101) C07D 217/12 (20130101) C07D 217/16 (20130101) C07D 231/12 (20130101) C07D 405/04 (20130101) C07D 413/12 (20130101) C07D 498/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402471 | Whalen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott A. Whalen (West Richland, Washington); Jens T. Darsell (West Richland, Washington); MD. Reza-E-Rabby (Richland, Washington); Brandon Scott Taysom (West Richland, Washington); Tianhao Wang (Richland, Washington); Darrell R. Herling (Kennewick, Washington); Xiao Li (Richland, Washington) |
| ABSTRACT | A method for preparing a shear-assisted extruded material from a powder billet is provided, the method comprising providing a billet of material in substantially powder form; applying both axial and rotational pressure to the material to deform at least some of the contacted material; and extruding the material to form an extruded material. A method for preparing shear-assisted extruded material is provided, the method comprising applying both axial and rotational pressure to stock material to form an extruded material at a rate between 2 and 13 m/min. A method for preparing shear-assisted extruded material is provided. The method comprises applying both axial and rotational pressure to stock material to form an extruded material; and aging the extruded material for less than 3 hours. A method for preparing shear-assisted extruded material is provided. The method comprises providing a stock material for shear-assisted extrusion; and applying both axial and rotational force to the stock material to form an extruded material, wherein the axial force does not decrease during the extrusion. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473178 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/20 (20130101) Original (OR) Class B22F 3/24 (20130101) B22F 2003/248 (20130101) B22F 2301/052 (20130101) B22F 2302/25 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403421 | LYMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mathew Gerald LYMAN (Livermore, California); Lawrence DUGAN (Livermore, California); Roald N. LEIF (Livermore, California); Bonnee RUBINFELD (Livermore, California); Brian E. SOUZA (Livermore, California); Carlos A. VALDEZ (Livermore, California) |
| ABSTRACT | Biodegradable surfactants are described, in which an amphiphilic heteroatom containing hydrocarbon optionally comprising at least one counterion (Z), and related compositions, methods and systems. Biodegradable surfactant described herein has an aHLB value in accordance with equation (1): aHLB=20*Gh/(Gh−Gt) (1) wherein Gh is the Group Number of a hydrophilic head portion of the biodegradable surfactant optionally comprising the at least one counterion (Z), and Gt is the Group Number of a hydrophobic tail portion of the biodegradable surfactant. A biodegradable surfactant in the sense of the disclosure can be tuned to a set hydrophilic-lipophilic balance (aHLB) by selectively modifying at least one tuning moiety of the biodegradable surfactants to provide tuned biodegradable surfactants having an increase or decrease in their adjusted hydrophilic-lipophilic balance (aHLB). |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/350875 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 69/675 (20130101) C07C 69/708 (20130101) C07C 305/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403445 | Coates et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey W. Coates (Lansing, New York); Aran K. Hubbell (Ithaca, New York) |
| ABSTRACT | Provided are methods of carbonylating cyclic substrates to produce carbonylated cyclic products. The cyclic substrates may be 2, 2-di substituted epoxides and the cyclic products may be β,β-di substituted lactones. The method may be carried out by forming and pressurizing a reaction mixture of the cyclic substrate, a solvent, carbon monoxide, and a [LA+][CO(CO)4−] catalyst, where [LA+] is a Lewis acid capable of coordinating to the cyclic substrate. The method may proceed with a regio selectivity of 90:10 or greater. The resulting carbonylated cyclic products may be converted to ketone aldol products that retain the stereochemistry and enantiomeric ratio of the carbonylated cyclic products. |
| FILED | Monday, November 18, 2019 |
| APPL NO | 17/293424 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/183 (20130101) B01J 31/2217 (20130101) B01J 2231/321 (20130101) B01J 2531/31 (20130101) Acyclic or Carbocyclic Compounds C07C 67/37 (20130101) Heterocyclic Compounds C07D 305/12 (20130101) Original (OR) Class Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/069 (20130101) C07F 11/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403739 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanliang Zhang (South Bend, Indiana); Minxiang Zeng (South Bend, Indiana) |
| ABSTRACT | Provided are an ink composition, comprising greater than 0.2% by weight a graphene quantum dot nanosurfactant, a printable material, and a solvent, wherein the printable material is dispersed in the solvent by the graphene quantum dot nanosurfactant, and a method of preparing an ink composition. Advantageously, the present ink composition may be printed onto 2D and 3D substrates to form printed films with improved mechanical stability and photoconductance. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357805 |
| CURRENT CPC | Printing, Duplicating, Marking, or Copying Processes; Colour Printing, B41M 5/0023 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/033 (20130101) C09D 11/037 (20130101) C09D 11/38 (20130101) Original (OR) Class C09D 11/52 (20130101) C09D 11/322 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403883 | Clark et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Industrial Microbes, Inc. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth Jane Clark (San Francisco, California); Derek Lorin Greenfield (Kensington, California); Noah Charles Helman (El Cerrito, California); Stephanie Rhianon Jones (Berkeley, California); Baolong Zhu (Johnston, Iowa) |
| ABSTRACT | Improved soluble methane monooxygenases and soluble methane monooxygenase systems are provided. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461102 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0073 (20130101) Original (OR) Class C12N 15/70 (20130101) C12N 15/75 (20130101) C12N 15/77 (20130101) Enzymes C12Y 114/13025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403995 | Mutalik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivek K. Mutalik (Albany, California); Adam P. Arkin (San Francisco, California); Adam M. Deutschbauer (Berkeley, California) |
| ABSTRACT | The present invention provides for a method for screening for gene function for a bacteriophage, the method comprising: (1) (a) providing one or more host organism, such as a species or strain, libraries, (b) providing randomly barcoded transposon sequencing (such as RB-TnSeq), and (c) screening for loss-of-function (LOF) mutant phenotypes; or (2) (a) providing one or more DNA barcoded overexpression strain libraries (such as Dub-seq) using DNA of the host organism and/or phage, and (b) screening for gain-of-function (GOF). |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473968 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1082 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404091 | GAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (New York, New York); NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang GAO (New York, New York); Tengfei CAO (New York, New York); Filippo CELLINI (New York, New York); Elisa RIEDO (New York, New York); Angelo BONGIORNO (New York, New York) |
| ABSTRACT | An ultra-hard carbon film is formed by the uniaxial compression of thin films of graphene. The graphene films are two or three layers thick (2-L or 3-L). High pressure compression forms a diamond-like film and provides improved properties to the coated substrates. |
| FILED | Monday, October 22, 2018 |
| APPL NO | 16/757306 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 31/245 (20190201) Hats; Head Coverings A42B 3/04 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/194 (20170801) C01B 2204/04 (20130101) C01B 2204/26 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/03 (20130101) C01P 2004/04 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/025 (20130101) C30B 29/02 (20130101) C30B 33/00 (20130101) Original (OR) Class Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/0414 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404436 | LEHMANN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marcus LEHMANN (Berkeley, California); Mohammed-Reza ALAM (Berkeley, California); Thomas BOERNER (Berkeley, California); Nigel KOJIMOTO (Berkeley, California); Bryan MURRAY (Berkeley, California) |
| ABSTRACT | A submergible wave energy converter and method for using the same are described. Such a wave energy converter may be used for deep water operations. In one embodiment, the wave energy converter apparatus comprises an absorber having a body with an upper surface and a bottom surface and at least one power take-off (PTO) unit coupled to the absorber and configured to displace movement of the absorber body relative to a reference, where the power take-off unit is operable to perform motion energy conversion based on displacement of the absorber body relative to the reference in response to wave excitation, and where the power take-off unit is operable to return the absorber body from a displaced position to a predefined equilibrium position and to provide a force acting on the absorber body for energy extraction. |
| FILED | Wednesday, March 31, 2021 |
| APPL NO | 17/219261 |
| CURRENT CPC | Machines or Engines for Liquids F03B 13/10 (20130101) Original (OR) Class F03B 13/148 (20130101) F03B 13/186 (20130101) F03B 13/187 (20130101) Indexing Scheme Relating to Wind, Spring, Weight, Inertia or Like Motors, to Machines or Engines for Liquids Covered by Subclasses F03B, F03D and F03G F05B 2250/22 (20130101) F05B 2250/72 (20130101) F05B 2260/406 (20130101) F05B 2270/18 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/20 (20130101) Y02E 10/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404542 | Raymond et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William T. Radigan (, None); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. Raymond (Edgewood, New Mexico); William T. Radigan (Albuquerque, New Mexico) |
| ABSTRACT | A harmonic drive assembly and fluid-powered linear motors with both axial pistons are rotary piston arrangements incorporating the harmonic drive assembly are disclosed. The motors may be used in downhole drilling applications, but the drive assembly and/or motors may be used in other applications. The assembly, motors and methods use advanced harmonic drives, advanced helical drives, and combinations thereof with 1) motors with axial pistons and reciprocating linear rings to convert reciprocative axial motion to continuous rotary motion, and 2) motors with rotary pistons and reciprocating linear rings to rectify reciprocative rotary motion to continual rotary motion to improve performance over prior configurations. Axial pistons provide a robust simple solution for generating rotation; Rotational pistons provide increased torque generation as the torque generated is proportional to motor length. Since downhole drills are long, a high-torque motor can be produced using this method. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474721 |
| CURRENT CPC | Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 4/02 (20130101) E21B 4/006 (20130101) Gearing F16H 25/06 (20130101) F16H 25/122 (20130101) Original (OR) Class F16H 49/001 (20130101) F16H 2025/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404884 | Skifton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard S. Skifton (Idaho Falls, Idaho); Joshua Daw (Idaho Falls, Idaho); Douglas A. Corbett (Rigby, Idaho) |
| ABSTRACT | A multi-core thermocouple includes a plurality of wires, an insulation core surrounding the plurality of wires, a sheath surrounding the insulation core, and a plurality of electrical junctions. The plurality of electrical junctions may include a first electrical junction formed between a first wire of the plurality of wires and the sheath at a first axial mid-section of the multi-core thermocouple, the first electrical junction including a first swaged axial mid-section of the sheath and a second electrical junction formed between a second wire of the plurality of wires and the sheath at a second, different axial mid-section of the multi-core thermocouple, the second electrical junction including a second swaged axial mid-section of the sheath. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/946657 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 1/08 (20130101) G01K 7/04 (20130101) G01K 7/021 (20130101) Original (OR) Class G01K 7/023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404926 | Milholland |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| INVENTOR(S) | Roger A. Milholland (Sheridan, Illinois) |
| ABSTRACT | A portable, case-enclosed pressure test manifold, configured to support both pneumatic and hydrostatic pressure testing, and comprising a downstream fluid path (e.g., a test gauge, a vent valve, a system test port, a relief valve, and various other high-pressure rated components/piping) and an upstream fluid path (e.g., a low-pressure gauge, a high-pressure gauge, and various other low-pressure rated components/piping). A regulator and/or the vent valve selectively operate the downstream fluid path, defining a high-pressure fluid path, to receive a liquid; and the upstream fluid path in combination with the downstream fluid path, defining a low-pressure fluid path, to receive a gas. Manifold components are pressure rated based on use and are ASME Code B31.3 compliant. A flexible hose connects with either of the low-pressure fluid path and the high-pressure fluid path of the manifold. The case includes parking receptacles and a carrying handle configured to stow the hose during transport. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/916437 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/12 (20130101) Original (OR) Class G01N 2203/0048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404935 | DONOHUE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Marc DONOHUE (Baltimore, Maryland); Gregory ARANOVICH (Baltimore, Maryland) |
| ABSTRACT | In some aspects, a device may receive measurement data associated with a measurement subject. The device may determine an adsorption isotherm for the measurement subject based on the measurement data. The device may determine a thermodynamic adsorption capacity of the measurement subject based on the adsorption isotherm. The device may determine a surface area value associated with the measurement subject based on the thermodynamic adsorption capacity. The device may provide an output based on the adsorption capacity or the surface area value associated with the measurement subject. |
| FILED | Tuesday, November 12, 2019 |
| APPL NO | 17/309268 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/088 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404986 | Cieslewski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Grzegorz Cieslewski (Orlando, Florida); Xuhua Gao (Stanford, California); Ryan Falcone Hess (Sandia Park, New Mexico); Avery T. Cashion, IV (Albuquerque, New Mexico); William Corbin (Rio Rancho, New Mexico); Sasha Egan (Belen, New Mexico); Roland N. Horne (Stanford, California) |
| ABSTRACT | The present disclosure is directed to systems, methods and tools that measure ionic concentrations and downhole enthalpy of a flowing geothermal fluid in real-time at high-temperature and pressure. The systems, methods and tools include measuring the concentration of selected naturally occurring ions found in the liquid phase of the geothermal fluid throughout the wellbore using novel electrochemical sensor technologies. The change in liquid-phase ion concentration will be used to calculate the proportion of liquid to steam and allow for accurate enthalpy measurements. The techniques and technologies described here can be applied to any application of electrochemical sensing in extreme environments. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474560 |
| CURRENT CPC | Geothermal Collectors; Geothermal Systems F24T 10/20 (20180501) F24T 10/30 (20180501) F24T 2201/00 (20180501) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 17/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4162 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404989 | WILMER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); UNITED STATES DEPARTMENT OF ENERGY (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (PITTSBURGH, Pennsylvania); UNITED STATES DEPARTMENT OF ENERGY (WASHINGTON, District of Columbia) |
| INVENTOR(S) | CHRISTOPHER E. WILMER (PITTSBURGH, Pennsylvania); JENNA GUSTAFSON (PITTSBURGH, Pennsylvania); PAUL R. OHODNICKI (ALLISON PARK, Pennsylvania); JAGANNATH DEVKOTA (PITTSBURGH, Pennsylvania) |
| ABSTRACT | A gas sensor (100,200) includes at least one sensor device including a surface acoustic wave (SAW) device (110) or a quartz crystal microbalance (QCM) device (210), and a layer of metal organic framework (MOF) material (120,220) disposed on each of the at least one sensor device. The at least one sensor device is structured to sense a change in mass of the MOF material. |
| FILED | Friday, January 26, 2018 |
| APPL NO | 16/479675 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/022 (20130101) Original (OR) Class G01N 33/004 (20130101) G01N 2291/021 (20130101) G01N 2291/106 (20130101) G01N 2291/0256 (20130101) G01N 2291/0423 (20130101) G01N 2291/0426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405086 | te Velthuis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suzanne Gabriëlle Everdine te Velthuis (Naperville, Illinois); Michael Claus Siegfried Vogel (Westmont, Illinois); Axel Friedrich Hoffmann (Champaign, Illinois) |
| ABSTRACT | Sub-diffraction limited magneto-optical microscopy, such as Kerr or Faraday effect microscopy, provide many advantages to fields of science and technology for measuring, or imaging, the magnetization structures and magnetization domains of materials. Disclosed is a method and system for performing sub-diffraction limited magneto-optic microscopy. The method includes positioning a microlens or microlens layer relative to a surface of a sample to image the surface of the sample, forming a photonic nanojet to probe the surface of the sample, and receiving light reflected by the surface of the sample or transmitted through the sample at an imaging sensor. The methods and associated systems and devices enable sub-diffraction limited imaging of magnetic domains at resolutions 2 to 8 times the classical diffraction limit. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/916895 |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/50 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0322 (20130101) G01R 33/0325 (20130101) Optical Elements, Systems, or Apparatus G02B 21/0016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405318 | Monroe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | James Alan Monroe (College Station, Texas); David Scott Content (Spring, Texas); Jeremy Sean McAllister (Bryan, Texas); Jay Russell Zgarba (Sugar Land, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Alan Monroe (College Station, Texas); David Scott Content (Spring, Texas); Jeremy Sean McAllister (Bryan, Texas); Jay Russell Zgarba (Sugar Land, Texas) |
| ABSTRACT | A lens alignment system and method is disclosed. The disclosed system/method integrates one or more lens retaining members/tubes (LRM/LRT) and focal length spacers (FLS) each comprising a metallic material product (MMP) specifically manufactured to have a thermal expansion coefficient (TEC) in a predetermined range via selection of the individual MMP materials and an associated MMP manufacturing process providing for controlled TEC. This controlled LRM/LRT TEC enables a plurality of optical lenses (POL) fixed along a common optical axis (COA) by the LRM/LRT to maintain precise interspatial alignment characteristics that ensure consistent and/or controlled series focal length (SFL) within the POL to generate a thermally neutral optical system (TNOS). Integration of the POL using this LRM/LRT/FLS lens alignment system reduces the overall TNOS implementation cost, reduces the overall TNOS mass, reduces TNOS parts component count, and increases the reliability of the overall optical system. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/467738 |
| CURRENT CPC | Alloys C22C 14/00 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/183 (20130101) Optical Elements, Systems, or Apparatus G02B 7/003 (20130101) G02B 7/028 (20130101) Original (OR) Class G02B 23/2407 (20130101) G02B 27/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405319 | Monroe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | James Alan Monroe (College Station, Texas); David Scott Content (Spring, Texas); Jeremy Sean McAllister (Bryan, Texas); Jay Russell Zgarba (Sugar Land, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Alan Monroe (College Station, Texas); David Scott Content (Spring, Texas); Jeremy Sean McAllister (Bryan, Texas); Jay Russell Zgarba (Sugar Land, Texas) |
| ABSTRACT | A lens alignment system and method is disclosed. The disclosed system/method integrates one or more lens retaining members/tubes (LRM/LRT) and focal length spacers (FLS) each comprising a metallic material product (MMP) specifically manufactured to have a thermal expansion coefficient (TEC) in a predetermined range via selection of the individual MMP materials and an associated MMP manufacturing process providing for controlled TEC. This controlled LRM/LRT TEC enables a plurality of optical lenses (POL) fixed along a common optical axis (COA) by the LRM/LRT to maintain precise interspatial alignment characteristics that ensure consistent and/or controlled series focal length (SFL) within the POL to generate a thermally neutral optical system (TNOS). Integration of the POL using this LRM/LRT/FLS lens alignment system reduces the overall TNOS implementation cost, reduces the overall TNOS mass, reduces TNOS parts component count, and increases the reliability of the overall optical system. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/467753 |
| CURRENT CPC | Alloys C22C 14/00 (20130101) Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys C22F 1/183 (20130101) Optical Elements, Systems, or Apparatus G02B 7/003 (20130101) G02B 7/028 (20130101) Original (OR) Class G02B 23/2407 (20130101) G02B 27/0012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405503 | Pooser et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raphael C. Pooser (Oak Ridge, Tennessee); Benjamin J. Lawrie (Oak Ridge, Tennessee); Petro Maksymovych (Oak Ridge, Tennessee) |
| ABSTRACT | A truncated non-linear interferometer-based sensor system includes an input that receives an optical beam and a non-linear amplifier that generates a probe beam and a conjugate beam from the optical beam. The system's local oscillators are related to the probe beam and the conjugate beam. The system includes a sensor that transduces an input with the probe beam and the conjugate beam. The transduction detects changes in the phase of each of the probe beam and the conjugate beam. The system's phase sensitive detectors detect phase modulations between the respective local oscillators, the probe beam, and the conjugate beam and outputs phase signals based on detected phase modulations. The system measures phase signals indicative of the sensor's input resulting from a sum or difference of the phase signals. The measurement exhibits a quantum noise reduction in an intensity difference, a phase sum, or an amplitude difference quadrature. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/472269 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 35/00 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02 (20130101) G01B 9/02003 (20130101) G01B 9/02079 (20130101) G01B 9/02081 (20130101) G01B 2290/55 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 20/02 (20130101) G01Q 60/24 (20130101) G01Q 60/38 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/29 (20130101) G02F 1/3538 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/10076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405659 | Chowdhary et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Girish Chowdhary (Champaign, Illinois); Girish Joshi (Redmond, Washington); Jasvir Virdi (Urbana, Illinois) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, determining, at a slower time-scale, inner layer weights of an inner layer of a deep neural network; providing periodically to an outer layer of the deep neural network from the inner layer, a feature vector based upon the inner layer weights; and determining, at a faster time-scale, outer layer weights of the outer layer, wherein the outer layer weights are determined in accordance with a Model Reference Adaptive Control (MRAC) update law that is based upon the feature vector from the inner layer, and wherein the outer layer weights are determined more frequently than the inner layer weights. Other embodiments are disclosed. |
| FILED | Tuesday, June 22, 2021 |
| APPL NO | 17/354912 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) G05D 1/101 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406183 | Mashimo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susumu Mashimo (Boxborough, Massachusetts); John Kalamatianos (Boxborough, Massachusetts) |
| ABSTRACT | A method includes recording a first set of consecutive memory access deltas, where each of the consecutive memory access deltas represents a difference between two memory addresses accessed by an application, updating values in a prefetch training table based on the first set of memory access deltas, and predicting one or more memory addresses for prefetching responsive to a second set of consecutive memory access deltas and based on values in the prefetch training table. |
| FILED | Monday, July 13, 2020 |
| APPL NO | 16/927786 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/30036 (20130101) G06F 9/30047 (20130101) G06F 9/30101 (20130101) G06F 12/0862 (20130101) Original (OR) Class G06F 12/0877 (20130101) G06F 2212/6024 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210407075 | Severa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Mark Severa (Albuquerque, New Mexico); John Darby Smith (Albuquerque, New Mexico); Suma George Cardwell (Albuquerque, New Mexico) |
| ABSTRACT | A spiking retina microscope comprising microscope optics and a neuromorphic imaging sensor. The microscope optics are configured to direct a magnified image of a specimen onto the neuromorphic imaging sensor. The neuromorphic imaging sensor comprises a plurality of sensor elements that are configured to generate spike signals in response to integrated light from the magnified image reaching a threshold. The spike signals may be processed by a processor unit to generate a result, such as tracking biological particles in a specimen comprising biological material. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 16/913765 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6267 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/20 (20130101) G06T 2207/10056 (20130101) G06T 2207/30024 (20130101) Pictorial Communication, e.g Television H04N 5/2253 (20130101) H04N 5/2254 (20130101) H04N 7/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210407699 | Rotsch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | David A. Rotsch (Montgomery, Illinois); Thomas W. Brossard (Naperville, Illinois); Ronald T. Kmak (Homer Glen, Illinois); Peter Tkac (Naperville, Illinois) |
| ABSTRACT | The invention provides an automated method for isolating a targeted isotope, the method having the steps of supplying a dissolved uranium targets into a first reaction environment; precipitating non-targeted isotope within the first reaction environment transferring liquid phase targeted isotope to a second reaction environment; precipitating the liquid phase targeted isotope in the second reaction environment; dissolving the precipitated targeted isotope; transferring the dissolved targeted isotope to a third reaction environment; and precipitating non-targeted isotope (i.e., iodine), such that the targeted isotope remains in the solution. Also provided is an automated system for isolating isotopes, the system having a plurality of reaction environments adapted to pneumatically receive and disgorge reactants and products via remotely actuated valves positioned between each of the reaction environments. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/916278 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 1/001 (20130101) Original (OR) Class G21G 1/0005 (20130101) G21G 2001/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210408318 | Santhanam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Parthiban Santhanam (Redwood City, California); Shanhui Fan (Stanford, California) |
| ABSTRACT | Shockley-Read-Hall (SRH) generation and/or recombination in heterojunction devices is suppressed by unconventional doping at or near the heterointerface. The effect of this doping is to shift SRH generation and/or recombination preferentially into the wider band gap material of the heterojunction. This reduces total SRH generation and/or recombination in the device by decreasing the intrinsic carrier concentration ni at locations where most of the SRH generation and/or recombination occurs. The physical basis for this effect is that the SRH generation and/or recombination rate tends to decrease as ni around the depletion region decreases, so decreasing the effective ni in this manner is a way to decrease SRH recombination. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358980 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/072 (20130101) H01L 31/109 (20130101) Original (OR) Class H01L 33/002 (20130101) H01L 33/06 (20130101) H01L 33/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210408422 | FORREST et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (ANN ARBOR, Michigan); THE UNIVERSITY OF SOUTHERN CALIFORNIA (LOS ANGELES, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. FORREST (Ann Arbor, New Jersey); Michael SLOOTSKY (Ann Arbor, Michigan); Mark E. THOMPSON (Anaheim, California) |
| ABSTRACT | Arrangements and techniques for providing organic emissive layers are provided, in which the emissive layer includes a first dopant having a dissociative energy level. A second dopant in the emissive layer provides a solid state sink energy level, to which doubly excited excitons and/or polarons may transition instead of to the dissociative energy level, thereby decreasing the undesirable effects of transitions to the dissociative energy level. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317266 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1007 (20130101) C09K 2211/1011 (20130101) C09K 2211/1044 (20130101) C09K 2211/1088 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/5016 (20130101) H01L 51/5028 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210408555 | Steinbach et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | 3M INNOVATIVE PROPERTIES COMPANY (St. Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J.L. Steinbach (Shoreview, Minnesota); Andrew T. Haug (Woodbury, Minnesota); Krzysztof A. Lewinski (Mahtomedi, Minnesota); Amy E. Hester (Hudson, Wisconsin); Grant M. Thoma (Woodbury, Minnesota); Cedric Bedoya (Woodbury, Minnesota) |
| ABSTRACT | Catalyst comprising an Ir layer having an outer layer with a layer comprising Pt directly thereon, wherein the Ir layer has an average thickness in a range from 0.04 to 30 nanometers, wherein the layer comprising Pt has an average thickness in a range from 0.04 to 50 nanometers, and wherein the Pt and Ir are present in an atomic ratio in a range from 0.01:1 to 10:1. Catalysts described herein are useful, for example, in fuel cell membrane electrode assemblies. |
| FILED | Thursday, April 11, 2019 |
| APPL NO | 15/733735 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/921 (20130101) Original (OR) Class H01M 2008/1095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210408923 | Sun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keyao Sun (Blacksburg, Virginia); Jun Wang (Blacksburg, Virginia); Rolando Burgos (Blacksburg, Virginia); Dushan Boroyevich (Blacksburg, Virginia) |
| ABSTRACT | Aspects of an efficient compensation network for reducing reactive power in a wireless power transfer (WPT) system are disclosed. The compensation network comprises a series/series (S/S) constant current (CC) source, a reactive power compensation capacitor, and a constant current (CC)-to-constant voltage (CV) network. In an example, the S/S CC source comprises a first capacitor connected in series with a first inductor on a primary side of a transformer and a second inductor on a secondary side of the transformer. The S/S CC source converts an input voltage signal of the WPT system into a constant alternating current (AC) current signal. In an example, the CC-to-CV network comprises at least a third capacitor and a third inductor. The CC-to-CV network converts the constant AC current signal into a constant AC voltage signal. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 16/913066 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/12 (20160201) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/126 (20130101) H02M 3/33576 (20130101) Original (OR) Class H02M 7/219 (20130101) H02M 7/5387 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210408940 | Wasynczuk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Oleg Wasynczuk (West Lafayette, Indiana); Minyu Cai (Roseville, Minnesota) |
| ABSTRACT | An auxiliary resonant soft-edge pole inverter circuit is provided. The power inverter circuitry may include a first pair of capacitors in parallel with a corresponding pair of main power switching modules, each power switching module comprising a switch and a diode in parallel and sharing a common central node with the first pair of capacitors. The power inverter circuit may further include a first pair of auxiliary switches connected in series with a first pair of inductors, respectively, to generate resonant current from a DC power source, the first pair of inductors also sharing the common central node. The power inverter circuitry may further include a second pair of auxiliary switches connected in series with a second pair of capacitors, respectively, the second pair of auxiliary switches also sharing the common central node, the circuit producing an alternating current output at the common central node. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 16/887013 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/5387 (20130101) Original (OR) Class H02M 2007/4815 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210409008 | Wu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| INVENTOR(S) | Jinyuan Wu (Aurora, Illinois) |
| ABSTRACT | A pure digital ring oscillator with constant power consumption as oscillation frequency is adjusted. Circuit topology includes a multiplexer implemented in NAND gates and a delay element positioned after a path selection NAND gate of that multiplexer such that delay element transistors may not toggle if the non-delaying signal path is selected. Assuming a delay element oscillation frequency f and a total capacitance C, and also assuming a plurality N of delay gates each characterized by a propagation delay t1 and a capacitance C1 such that C=C1*N, the ring oscillator of the present invention is characterized by a C value that is proportional to N and an f value that is inversely proportional to N. Furthermore, each of the N delay gates as well as the input and output gates of the multiplexer are characterized by a common capacitance-to-propagation delay ratio=C1/t1. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/916473 |
| CURRENT CPC | Pulse Technique H03K 3/0315 (20130101) Original (OR) Class H03K 5/00 (20130101) H03K 19/20 (20130101) H03K 2005/00078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20210401967 | DE LOS SANTOS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); CODAGENIX INC. (FARMINGDALE, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | TERESA B. DE LOS SANTOS (MILLER PLACE, New York); AIDA E. RIEDER (WESTBROOK, Connecticut); FAYNA C. DIAZ-SAN SEGUNDO (BLUE POINT, New York); ANNA KLOC (GUILFORD, Connecticut); JOHN R. COLEMAN (BLAUVELT, New York); STEFFEN MUELLER (KINGS POINT, New York); GISSELLE N. MEDINA (Sound Beach, New York) |
| ABSTRACT | The present disclosure describes deoptimized foot and mouth viruses and their use for prophylactic and therapeutic treatment of mammalian subjects. The recombinant viruses provided herein include alterations in several genomic regions as well as Differentiating Infected from Vaccinated Animals (DIVA) markers. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/330545 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/135 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/32121 (20130101) C12N 2770/32134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403325 | Cai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiyong Cai (Madison, Wisconsin); Qiangu Yan (Starkville, Mississippi); Jinghao Li (Madison, Wisconsin) |
| ABSTRACT | A method of making a carbon foam comprises subjecting a precursor composition comprising an amount of at least partially decomposed lignin to a first pressure for a first time, optionally, while heating the precursor composition to a first temperature; heating the compressed precursor composition to a second temperature for a second period of time while subjecting the compressed precursor composition to a second pressure to further decompose the at least partially decomposed lignin and to generate pores within the compressed precursor composition, thereby providing a porous, decomposed precursor composition; and heating the porous, decomposed precursor composition to a third temperature for a third time to carbonize, and optionally, to graphitize, the porous, decomposed precursor composition to provide the carbon foam. Also provided are the carbon foams and composites made from the carbon foams. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/468851 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/00 (20170801) C01B 32/184 (20170801) Original (OR) Class C01B 2204/04 (20130101) C01B 2204/26 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/03 (20130101) Compositions of Macromolecular Compounds C08L 97/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403346 | Shi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Shi (Lexington, Kentucky); Wenqi Li (Lexington, Kentucky); Jameson Hunter (Lexington, Kentucky); Yuxuan Zhang (Lexington, Kentucky); Qing Shao (Lexington, Kentucky) |
| ABSTRACT | Methods for detecting and extracting plastic contaminants within a water sample, which involve introducing the water sample to a hydrophobic deep eutectic solvent, are provided. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362515 |
| CURRENT CPC | Separation B01D 11/0492 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/26 (20130101) Original (OR) Class C02F 2101/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/94 (20130101) G01N 33/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403401 | Bolling et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| INVENTOR(S) | Bradley Bolling (Madison, Wisconsin); Yuwei Wu (Madison, Wisconsin); Danielle Voss (Wrightstown, Wisconsin); Matthew Dorris (Fitchburg, Wisconsin) |
| ABSTRACT | Methods of isolating phenols from phenol-containing media. The methods include combining a phospholipid-containing composition with the phenol-containing medium to generate a combined medium, incubating the combined medium to precipitate phenols in the combined medium and thereby form a phenol precipitate phase and a phenol-depleted phase, and separating the phenol precipitate phase and the phenol-depleted phase. The methods can further include extracting phenols from the separated phenol precipitate phase. The extracting can include mixing the separated phenol precipitate phase with an extraction solvent to solubilize in the extraction solvent at least a portion of the phenols originally present in the phenol precipitate phase. |
| FILED | Thursday, September 09, 2021 |
| APPL NO | 17/470539 |
| CURRENT CPC | Separation B01D 11/0419 (20130101) B01D 11/0492 (20130101) Acyclic or Carbocyclic Compounds C07C 37/72 (20130101) C07C 37/86 (20130101) Original (OR) Class C07C 39/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403860 | GANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WASHINGTON STATE UNIVERSITY (Pullman, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Roger GANG (Moscow, Idaho); Haluk BEYENAL (Pullman, Washington); Anders OMSLAND (Moscow, Idaho); Elham ATTARAN (Pullman, Washington); Phuc HA (Richland, Washington); Banafsheh MOLKI (Pullman, Washington); Douglas CALL (Pullman, Washington) |
| ABSTRACT | The invention relates to compositions comprising Candidatus Liberibacter. The invention includes growth mediums, microbial cultures, methods, assays, and kits related to the compositions comprising Candidatus Liberibacter. |
| FILED | Thursday, November 14, 2019 |
| APPL NO | 17/293696 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class C12N 1/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210403889 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AUBURN UNIVERSITY (Auburn, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yi WANG (Auburn, Alabama); Jie ZHANG (Auburn, Alabama) |
| ABSTRACT | A system for modifying the genome of Clostridium strains is provided based on a modified endogenous CRISPR array. The application also describes Clostridium strains modified for enhanced butanol production wherein the modified strains are produced using the novel CRISPR-Cas system. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/469386 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 9/22 (20130101) Original (OR) Class C12N 15/63 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20210404683 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fu Lin (Glastonbury, Connecticut); Massimiliano L. Chiodo (Piedmont, California); Hala Mostafa (Marlborough, Connecticut) |
| ABSTRACT | Building response systems and methods of building responses are described. The building response systems include a building monitoring system configured to detect the presence of a harmful agent within an enclosed space, a building management system configured to monitor a building status and control building systems, a middleware system configured to receive information from each of the building monitoring system and the building management system, wherein the information from the building monitoring system comprises an alarm status and the information from the building management system comprises building status information, and a decision engine configured to receive information from the middleware system and to determine a mitigation action in response to receiving a positive alarm status. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 16/913517 |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/32 (20180101) Original (OR) Class F24F 11/49 (20180101) F24F 11/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404956 | Brown et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David M. Brown (Ellicott City, Maryland); Randall T. Hanna, II (Ellicott City, Maryland); Kevin C. Baldwin (Baltimore, Maryland); Andrea M. Brown (Ellicott City, Maryland) |
| ABSTRACT | An optical turbulence measurement system may include a camera assembly, a first optics assembly, a second optics assembly, and processing circuitry. The first optics assembly and the second optics assembly may be configured to magnify and direct a portion of a source beam received by a respective aperture to the camera assembly to be received as a two portions of a received beam. The processing circuitry may be configured to receive, from the camera assembly, a data representation of a first received beam from the first optics assembly and a second received beam from the second optics assembly, determine a focal spot displacement variance based on motion of a first focal spot corresponding to the first received beam relative to a second focal spot corresponding to the second received beam, and measure optical turbulence along a path of the source beam based on the focal spot displacement variance. |
| FILED | Wednesday, September 02, 2020 |
| APPL NO | 17/010007 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/538 (20130101) Original (OR) Class G01N 2201/0636 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405180 | Smith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Peter Roland Smith (Westfield, New Jersey); James Christopher Weatherall (Linwood, New Jersey); Jeffrey Brian Barber (Vineland, New Jersey); Barry Thomas Smith (Egg Harbor City, New Jersey) |
| ABSTRACT | The present disclosure is directed to a measurement system for measuring a reflection coefficient of a test sample, including: a transceiver antenna configured to be coupled to a source of electromagnetic radiation; and a RAM positioned between the transceiver antenna and a measurement region of the transceiver antenna, wherein the RAM comprises an aperture substantially orthogonal to and substantially aligned with a transceiving axis of the transceiver antenna. A method for obtaining error correction of a measurement system and a method of measuring a reflection coefficient in a test sample are also provided. |
| FILED | Thursday, April 29, 2021 |
| APPL NO | 17/244511 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/40 (20130101) G01S 7/411 (20130101) G01S 13/88 (20130101) G01S 13/0209 (20130101) G01S 13/887 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405182 | Reynolds et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Matthew S. Reynolds (Seattle, Washington); Andreas Pedross-Engel (Seattle, Washington); Claire Watts (Seattle, Washington); Sandamali Devadithya (Seattle, Washington) |
| ABSTRACT | Examples of imaging systems are described herein which may implement microwave or millimeter wave imaging systems. Examples described may implement partitioned inverse techniques which may construct and invert a measurement matrix to be used to provide multiple estimates of reflectivity values associated with a scene. The processing may be partitioned in accordance with a relative position of the antenna system and/or a particular beamwidth of an antenna. Examples described herein may perform an enhanced resolution mode of imaging which may steer beams at multiple angles for each measurement position. |
| FILED | Friday, December 08, 2017 |
| APPL NO | 16/467819 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/888 (20130101) G01S 13/9004 (20190501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210408422 | FORREST et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (ANN ARBOR, Michigan); THE UNIVERSITY OF SOUTHERN CALIFORNIA (LOS ANGELES, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. FORREST (Ann Arbor, New Jersey); Michael SLOOTSKY (Ann Arbor, Michigan); Mark E. THOMPSON (Anaheim, California) |
| ABSTRACT | Arrangements and techniques for providing organic emissive layers are provided, in which the emissive layer includes a first dopant having a dissociative energy level. A second dopant in the emissive layer provides a solid state sink energy level, to which doubly excited excitons and/or polarons may transition instead of to the dissociative energy level, thereby decreasing the undesirable effects of transitions to the dissociative energy level. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317266 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1007 (20130101) C09K 2211/1011 (20130101) C09K 2211/1044 (20130101) C09K 2211/1088 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/5016 (20130101) H01L 51/5028 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20210401874 | Golobish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CytoSorbents Corporation (Monmouth Junction, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Golobish (Princeton, New Jersey); Maryann Gruda (Yardley, Pennsylvania); Tamaz Guliashvili (Philadelphia, Pennsylvania); Pamela O'Sullivan (Manalapan, New Jersey); Andrew Scheirer (Hoboken, New Jersey); Vi Dan (East Brunswick, New Jersey); Wei-Tai Young (Hillsborough, New Jersey); Vincent Capponi (Lawrenceville, New Jersey); Phillip Chan (Cherry Hill, New Jersey) |
| ABSTRACT | The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/341912 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/795 (20130101) Original (OR) Class A61K 47/20 (20130101) A61K 47/26 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/3679 (20130101) A61M 5/165 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/264 (20130101) B01J 20/267 (20130101) B01J 20/28069 (20130101) B01J 39/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404333 | Knight et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Biota Technology, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rob Knight (San Diego, California); Ajay Kshatriya (Oakland, California); John Ely (Houston, Texas); Paul Henshaw (Clayton, California); J. Gregory Caporaso (Flagstaff, Arizona); Dan Knights (St. Paul, Minnesota); Ryan Gill (Denver, Colorado) |
| ABSTRACT | There are provided methods, systems and processes for the utilization of microbial and related genetic information for use in the exploration, determination, production and recovery of natural resources, including energy sources, and the monitoring, control and analysis of processes and activities. |
| FILED | Tuesday, March 09, 2021 |
| APPL NO | 17/196480 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/62 (20130101) C09K 8/582 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6874 (20130101) C12Q 1/6888 (20130101) C12Q 2600/156 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 43/00 (20130101) E21B 43/26 (20130101) E21B 47/11 (20200501) E21B 49/00 (20130101) E21B 49/08 (20130101) Original (OR) Class E21B 49/086 (20130101) E21B 49/0875 (20200501) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 9/00 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 10/00 (20190201) G16B 20/00 (20190201) G16B 20/20 (20190201) G16B 40/00 (20190201) G16B 45/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210404418 | Carlson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Valley Tech Systems, Inc. (Reno, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell Carlson (Reno, Nevada); Dustin Barr (Reno, Nevada); Allen Yan (Reno, Nevada); Justin Carpenter (Loomis, California) |
| ABSTRACT | Various implementations of an extinguishable, solid propellant divert system for a flight vehicle are disclosed. Also disclosed are methods for using the divert system to control the flight of a flight vehicle. In one implementation, a divert system includes a hot gas generator pneumatically linked to one or more divert thrusters and an extinguishment valve. The extinguishment valve can be opened to rapidly depressurize the hot gas generator and extinguish the solid propellant burning inside. In another implementation, a method of controlling the trajectory of the flight vehicle includes repeatedly igniting and extinguishing the solid propellant in a hot gas generator and using the hot gas to provide divert thrust for the flight vehicle. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/447623 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/403 (20130101) Jet-propulsion Plants F02K 9/26 (20130101) Original (OR) Class F02K 9/94 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210407620 | Westerhoff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | QuantumBio Inc. (state College, Pennsylvania) |
| ASSIGNEE(S) | QuantumBio Inc. (State College, Pennsylvania) |
| INVENTOR(S) | Lance Michael Westerhoff (Annville, Pennsylvania); Oleh Y. Borbulevych (Bellefonte, Pennsylvania); Roger Isaac Martin (State College, Pennsylvania) |
| ABSTRACT | The invention is a diagnostic which overlays quantum mechanical analysis to x-ray crystallography or Cryo-EM data from one or more molecules, to assess and identify the real world conformation, protonation and solvent effects of one or more moieties in said molecule. This “overlay” occurs by scoring and identifying the protomer/tautomer or conformational states of the moieties using quantum mechanical analysis. The diagnostic results of the present invention accurately identify protein-ligand binding, rendered as an output to a user of a computer in which the x-ray crystallography or Cryo-EM data is analysed with semi-empirical Hamiltonian quantum mechanics. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348074 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/20008 (20130101) G01N 33/6803 (20130101) G01N 2223/304 (20130101) G01N 2223/612 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Original (OR) Class G16B 20/00 (20190201) G16B 20/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20210406816 | Dearing et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen M. Dearing (Herndon, Virginia); Kuldip K. Goyal (Alexandria, Virginia); Carla F. Sherry (Annandale, Virginia); Amy B. Cradic (Reston, Virginia); C. Scot Atkins (Chantilly, Virginia); Himesh A. Patel (Centerville, Virginia) |
| ABSTRACT | Systems and methods of processing items. Items in a distribution network or process may be scanned at every handling point in the distribution network, and each scan is recorded in a central repository. The scan information can be used to generate real-time access to data, analytical tools, predictive tools, and tracking reports. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474964 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/18 (20130101) B07C 2301/0025 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1413 (20130101) G06K 7/1417 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/04 (20130101) G06Q 10/063 (20130101) G06Q 10/083 (20130101) G06Q 10/087 (20130101) Original (OR) Class G06Q 10/0833 (20130101) G06Q 30/0201 (20130101) G06Q 30/0241 (20130101) G06Q 50/28 (20130101) G06Q 50/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406819 | Tartal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Albert Tartal (Baltimore, Maryland); Gabriel Michael Yessin (Arlington, Virginia); Dominique Danielle Strothers (Front Royal, Virginia); Joram Shenhar (Fairfax, Virginia); Joel Locknauth Dewnandan (Bladensburg, Maryland); Terry Martin Gingell (Spotsylvania, Virginia); James Edmund Matthews (Bowie, Maryland) |
| ABSTRACT | A process for verifying an item deposit via a smart drop box. The process includes an item receptacle, a processor in communication with the item receptacle, a scanning device, and a database. The item receptacle is configured to receive an item from a user, scan the item, and generate item information. The processor is configured to compare the item information generated with identified item information from the database. If the information generated matches the information from the database, the item is accepted. In some embodiments, the deposit verification includes a printed receipt and/or an electronic verification. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/472372 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0832 (20130101) Original (OR) Class G06Q 10/0833 (20130101) G06Q 20/202 (20130101) G06Q 20/203 (20130101) G06Q 20/204 (20130101) G06Q 20/209 (20130101) G06Q 50/32 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 9/00896 (20130101) Handling of Coins or Valuable Papers, e.g Testing, Sorting by Denominations, Counting, Dispensing, Changing or Depositing G07D 11/009 (20130101) G07D 11/14 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406823 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David C. Lin (Falls Church, Virginia); Shahpour Ashaari (Bethesda, Maryland) |
| ABSTRACT | A system and method for automatically detecting and resolving item delivery issues in a distribution network is described. The system may include a memory configured to store electronic records of a plurality of items received by the distribution network. The system may further include a processor in data communication with the memory. The processor may process the electronic records of the plurality of items and determine whether there is a delivery issue on at least one of the plurality of items based on the electronic records. The processor may further automatically generate an internal case file in response to determining that there is a delivery issue on the at least one item and send notification to an intended recipient of the at least one item having the delivery issue. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/359119 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0833 (20130101) G06Q 10/0838 (20130101) Original (OR) Class G06Q 30/016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210406827 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mary P. Anderson (Washington, District of Columbia); James D. Wilson (Memphis, Tennessee); Angela D. Lawson (Memphis, Tennessee); Rosemarie Bolha (Wilkes-Barr, Pennsylvania) |
| ABSTRACT | A system and method for coordinating item delivery is disclosed. The system includes a control hub configured to receive item information, a dynamic routing system configured to provide routing instructions, and a handheld device configured to receive routing instructions. The control hub controls and coordinates receiving and transmitting item information, including pick-up and delivery schedules, and other item information. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/472331 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0836 (20130101) G06Q 10/08355 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20210401591 | Hansen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Department of Veterans Affairs (Washington, District of Columbia); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew H. Hansen (Apple Valley, Minnesota); Eric A. Nickel (Chicago, Illinois) |
| ABSTRACT | An ankle-foot prosthesis includes a foot plate, an ankle frame attached to the foot plate, a yoke pivotally connected to the ankle frame and including a member for attaching to a leg, a damper having a first end connected to the yoke and a second end connected to the ankle frame, and a control mechanism for switching the damper between low and high settings. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474127 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/6607 (20130101) Original (OR) Class A61F 2002/5006 (20130101) A61F 2002/6614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401802 | PATEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS OFFICE OF GENERAL (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | NIKETA A. PATEL (LAND O' LAKES, Florida); REKHA S. PATEL (TAMPA, Florida); ROBERT PLEASANTS SPARKS (TAMPA, Florida); WAYNE CHARLES GUIDA (SAINT PETE BEACH, Florida) |
| ABSTRACT | Provided herein are formulations that can contain an effective amount of a PKCδ inhibitor. Also provided herein are methods of inhibiting a PKCδ in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKCδ. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/472793 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/36 (20130101) A61K 31/357 (20130101) A61K 31/444 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/4035 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4965 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210401856 | PAHAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rush University Medical Center (Chicago, Illinois) |
| ASSIGNEE(S) | Rush University Medical Center (Chicago, Illinois) |
| INVENTOR(S) | Kalipada PAHAN (Skokie, Illinois) |
| ABSTRACT | Provided herein are methods for delivering acetylsalicylic acid via nasal delivery for the treatment of neurodegenerative and lysosomal storage disorders, such as Alzheimer's disease and Batten disease. |
| FILED | Tuesday, November 05, 2019 |
| APPL NO | 17/290798 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0043 (20130101) A61K 9/0078 (20130101) A61K 31/616 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20210403988 | Balijepalli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arvind Kumar Balijepalli (Washington, District of Columbia); Jacob Michael Majikes (Gaithersburg, Maryland) |
| ABSTRACT | A biomarker signal amplifier amplifies chemical analyte binding and includes: a surface strand disposed on an analysis substrate and including an exchange region; a particle strand hybridized to the surface strand in an absence of a chemical analyte that preferentially hybridizes to the exchange region as compared with the particle strand, and the particle strand is dissociated from the surface strand when the surface strand is in a presence of the chemical analyte; and a reporter particle attached to the particle strand and disposed proximate to the analysis substrate when the particle strand is hybridized to the surface strand in absence of the chemical analyte and that changes the electrical potential of the analysis substrate depending on whether the particle strand is hybridized to the surface strand. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/360008 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210405501 | ROLLINS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION (SILVER SPRING, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ANDREW ROLLINS (BOULDER, Colorado) |
| ABSTRACT | Embodiments of the present invention relate to methods and apparatus for detecting atmospheric NO at signal levels capable of distinguishing the NO isotopologues. More particularly, embodiments of the present invention relate to methods and apparatus for a single photon LIF sensor that pumps a vibronic transition near 215 nm and observes the resulting red shifted fluorescence from about 255 to about 267 nm. Embodiments of the present system uses a NO-LIF measurement fiber-amplified laser apparatus capable of: generating laser linewidth that is sufficiently narrow to resolve the Doppler broadened NO spectrum at room temperature and thereby achieve high signal levels and distinguish the NO isotopologues; generating laser repetition rate sufficient to enable single-photon counting of the fluorescence signal; and having size, weight and environmental robustness allowing for integration onto airborne platforms. |
| FILED | Friday, June 26, 2020 |
| APPL NO | 16/913088 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 33/0037 (20130101) G01N 2201/0612 (20130101) Optical Elements, Systems, or Apparatus G02B 27/286 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/353 (20130101) Original (OR) Class G02F 1/3501 (20130101) G02F 1/3551 (20130101) G02F 2001/354 (20130101) G02F 2001/3507 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0092 (20130101) H01S 3/06754 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20210405003 | Dasgupta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Purnendu K. Dasgupta (Arlington, Texas); Akinde F. Kadjo (Arlington, Texas); Charles Phillip Shelor (Arlington, Texas) |
| ABSTRACT | A method of converting longer path cell signal data to shorter path cell signal data comprising: obtaining a longer path absorbance signal tracing and a shorter path absorbance signal tracing for at least one analyte band under the same conditions; obtaining an approximate superimposable match between the longer path absorbance signal tracing and the shorter path absorbance signal tracing using an amplitude scaling factor and one or more parameters derived from a dispersion model that accounts for dispersion differences between a short cell and a long cell; and applying the dispersion model in reverse using the derived parameters to future longer path absorbance signal traces from the longer path cell signal data to generate the shorter path cell signal data. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226813 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/8617 (20130101) G01N 30/8624 (20130101) G01N 30/8693 (20130101) Original (OR) Class G01N 2030/8648 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210410283 | Bottiglio et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca Bottiglio (Hamden, Connecticut); Shanliangzi Liu (New Haven, Connecticut); Dylan Shah (New Haven, Connecticut); Lina Mercedes Sanchez Botero (New Haven, Connecticut) |
| ABSTRACT | A biphasic composition comprises a quantity of liquid GaIn and a plurality of solid particles of Ga2O3 suspended in the quantity of liquid GaIn, the Ga2O3 particles having a median particle size between 8 μm and 25 μm, wherein the volumetric ratio of solid particles of Ga2O3 to liquid GaIn is between 0.4 and 0.7. A method of making a biphasic composition of GaIn, a method of making a stretchable circuit board assembly, and a stretchable circuit board assembly are also described. |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357060 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0283 (20130101) H05K 1/0393 (20130101) Original (OR) Class H05K 3/4635 (20130101) H05K 2201/0233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20210404917 | Mayerich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Houston System (Houston, Texas) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas) |
| INVENTOR(S) | David Mayerich (Houston, Texas); Jason Eriksen (Houston, Texas) |
| ABSTRACT | Milling with ultraviolet excitation (MUVE) realizes high-throughput multiplex imaging of large three-dimensional samples. The instrumentation may comprise a UV-source attachment, precision stage attachment, and/or a blade assembly, and the instrumentation may overcome several constraints inherent to current state-of-the-art three-dimensional microscopy. MUVE offers throughput that is orders of magnitude faster than other technology by collecting a two-dimensional array of pixels simultaneously. The proposed instrumentation also utilizes serial ablation and provides the opportunity for true whole-organ imaging at microscopic resolution. |
| FILED | Friday, November 15, 2019 |
| APPL NO | 17/294489 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 1/36 (20130101) G01N 1/286 (20130101) G01N 21/6458 (20130101) G01N 2001/302 (20130101) G01N 2001/364 (20130101) G01N 2001/2873 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210409651 | Carlson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ennis-Flint, Inc. (Greensboro, North Carolina) |
| ASSIGNEE(S) | Ennis-Flint, Inc. (Greensboro, North Carolina) |
| INVENTOR(S) | Paul J. Carlson (Greensboro, North Carolina) |
| ABSTRACT | The disclosure provides a method for identifying a transportation infrastructure condition may comprise disposing a smart camera system on a vehicle and installing the smart camera system to the vehicle. The method may further comprise recording data from transportation infrastructure with the smart camera system, transmitting the data to a remote server with the transmitter, analyzing the data on the server, and accessing the data on the server with device. A system for identifying a transportation infrastructure condition may comprise a smart camera system disposed on a vehicle, wherein the smart camera system comprises a camera and transmitter, as well as a server capable to analyze data. A device may be configured to record and collect transportation infrastructure conditions. The camera system may comprise a camera, an electronic control module, a global positioning system, a single board computer, and a dashboard. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/316195 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00791 (20130101) G06K 9/00979 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/30 (20130101) Pictorial Communication, e.g Television H04N 7/181 (20130101) H04N 7/183 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Justice (DOJ)
| US 20210404777 | VABNICK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Federal Bureau of Investigation (Washington, District of Columbia) |
| ASSIGNEE(S) | The United States of America as represented by the Federal Bureau of Investigation, Dept. of Justice (Washington, District of Columbia) |
| INVENTOR(S) | Ian B. VABNICK (Fredericksburg, Virginia); Lee R. Foltz (Indian Head, Maryland); Daniel E. McCARTHY (La Plata, Maryland); Marc J. La Belle (Buffalo, New York); Michael S. SHATTUCK (Port Royal, Virginia) |
| ABSTRACT | Provided herein are shaped charges for focusing a fluid mass and related methods of using the shaped charges for disruption of an explosive target with a spherical projectile. The shaped charge comprises a plastic shell having a special geometric shape configured to support a shape-conforming explosive. A cylindrical plastic body has an interior volume for containing a fluid and the plastic shell. The plastic body closed distal end has a geometric shape that is substantially matched to the shape of the plastic shell. Metal spherical projectiles having an outer layer of metal selected to have an effective density matched to the fluid provide advantageous target disruption capabilities. |
| FILED | Monday, February 08, 2021 |
| APPL NO | 17/170304 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 1/028 (20130101) Original (OR) Class F42B 1/032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20210403755 | LIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhibin LIN (Fargo, North Dakota); Xingyu WANG (Fargo, North Dakota) |
| ABSTRACT | The invention relates to a curable coating composition comprising a nanoparticle-polymer composition and, optionally, superamphiphobic nanoparticles. The nanoparticle-polymer composition comprises the reaction product of an epoxy resin, a hydroxy-terminated poly(dimethylsiloxane), and a silane coupling agent, and a hybrid nanofiller. The superamphiphobic nanoparticles comprises the reaction product of silicon dioxide nanoparticles and 1H,1H,2H,2H-perfluorodecyltrichlorosilane and/or 1H,1H,2H,2H-perfluorododecyltrichlorosilane (FDDTS). The invention further relates to a cured coating composition of the invention, objects coated with the curable coating composition of the invention, methods for making the curable coating composition of the invention, and the use of the curable coating composition of the invention to coat substrates. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361886 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/031 (20130101) C09D 7/61 (20180101) C09D 7/63 (20180101) C09D 7/65 (20180101) C09D 163/00 (20130101) C09D 183/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20210405007 | Solomon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | US Environmental Protection Agency, Office of General Counsel - General Law Office (Washington, District of Columbia) |
| ASSIGNEE(S) | the United States Government, as represented by the Administrator of the U.S. Environmental Protecti (Washington, District of Columbia) |
| INVENTOR(S) | Paul Alan Solomon (Henderson, Nevada); Lara A. Gundel (Berkeley, California) |
| ABSTRACT | An inlet or primary particle size fractionator for a direct-reading PM2.5 mass sensor described herein may remove atmospheric particles of a given size, such as particles greater than the inlet cut point (e.g., having a 10 μm AD cut point) and may transport particles less than the cut point to a mass sensing element or a secondary particle size fractionator (e.g., having a 2.5 μm AD cut point). The inlet may have a flow rate range of between 1 mL/min and 50 mL/min (or higher flow rates depending on the application). The inlet may include a virtual impactor (VI), real impactor, cyclone, or virtual cyclone (VC). A sensing element may measure particle mass below the primary particle size fractionator (e.g., 2.5 μm AD particles with a 10 μm AD cut point inlet) and/or between the size range of the primary and secondary particle size fractionators (e.g., between 2.5 μm and 10 μm AD, or coarse particles). |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/917889 |
| CURRENT CPC | Weighing G01G 3/13 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/24 (20130101) G01N 1/28 (20130101) G01N 33/0031 (20130101) Original (OR) Class G01N 2001/245 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Reconnaissance Office (NRO)
| US 20210405182 | Reynolds et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Matthew S. Reynolds (Seattle, Washington); Andreas Pedross-Engel (Seattle, Washington); Claire Watts (Seattle, Washington); Sandamali Devadithya (Seattle, Washington) |
| ABSTRACT | Examples of imaging systems are described herein which may implement microwave or millimeter wave imaging systems. Examples described may implement partitioned inverse techniques which may construct and invert a measurement matrix to be used to provide multiple estimates of reflectivity values associated with a scene. The processing may be partitioned in accordance with a relative position of the antenna system and/or a particular beamwidth of an antenna. Examples described herein may perform an enhanced resolution mode of imaging which may steer beams at multiple angles for each measurement position. |
| FILED | Friday, December 08, 2017 |
| APPL NO | 16/467819 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/888 (20130101) G01S 13/9004 (20190501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20210405499 | Srinivasan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sudharsanan Srinivasan (Santa Barbara, California); Di Liang (Santa Barbara, California); Geza Kurczveil (Santa Barbara, California); Raymond G. Beausoleil (Seattle, Washington) |
| ABSTRACT | Examples herein relate to optical systems. In particular, implementations herein relate to an optical system including an optical transmitter configured to transmit optical signals. The optical transmitter includes a first optical source coupled to an input waveguide and configured to emit light having different wavelengths through the input waveguide. The optical transmitter includes a Mach-Zehnder interferometer that includes a first arm and a second arm. The MZI further includes a first optical coupler configured to couple the emitted light from the input waveguide to the first and second arms and an array of two or more second optical sources coupled to the first arm. Each of the two or more second optical sources are configured to be injection locked to a different respective wavelength of the emitted light transmitted from the first optical source. The MZI further includes a second optical coupler configured to combine the emitted light from the first and second arms after propagating therethrough. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/946653 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/225 (20130101) Original (OR) Class G02F 2001/212 (20130101) Transmission H04B 10/25 (20130101) H04B 10/503 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
20210403863 — MICROGLIA DERIVED FROM PLURIPOTENT STEM CELLS AND METHODS OF MAKING AND USING THE SAME
| US 20210403863 | Douvaras et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New York Stem Cell Foundation, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Panagiotis Douvaras (New York, New York); Scott Noggle (New Rochelle, New York); Stephen Chang (Poway, California); Valentina Fossati (New York, New York) |
| ABSTRACT | The present invention provides methods and compositions for the generation of microglial progenitor cells and microglial cells from pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells. The present invention also provides cells produced using such methods, and both methods of treatment and methods of drug screening that use such cells. Also provided are various tissue culture media, tissue culture media supplements, and kits useful for the generation of human microglial progenitor cells and human microglial cells. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473257 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0618 (20130101) C12N 5/0622 (20130101) Original (OR) Class C12N 2500/90 (20130101) C12N 2501/22 (20130101) C12N 2501/155 (20130101) C12N 2501/2334 (20130101) C12N 2506/45 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20210406757 | KIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jungsang KIM (Chapel Hill, North Carolina); Kenneth BROWN (Durham, North Carolina); Christopher MONROE (Ellicott City, Maryland) |
| ABSTRACT | Aspects of the present disclosure describe techniques that involve an active stabilization of coherent controllers using nearby qubits. In an aspect, a quantum information processing (QIP) system for stabilizing phase damping in qubits is described that provides a first and a second qubit ion, measuring magnetic field fluctuations using the second qubit ion, and generates one or more magnetic fields based on the measured magnetic field fluctuations, the one or more magnetic fields being applied near the first qubit ion to cancel the magnetic field fluctuations to stabilize the phase damping of the first qubit ion. Another such QIP system performs provides a first and a second qubit ion, locks a local oscillator to a frequency reference associated with the second qubit ion, and tracks, using the local oscillator, a frequency of the first qubit ion based on the frequency reference. Methods associated with these QIP systems are also described. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362810 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20210401791 | Talalay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Paul Talalay (Baltimore, Maryland); Yusuke Ushida (Baltimore, Maryland) |
| ABSTRACT | The present invention comprises methods and compositions for reducing ethanol toxicity due to accumulation of acetaldehyde in a cell. A method comprises administering to a cell a composition comprising a compound that increases the expression, the amount of, and/or the activity of at least one member of the aldehyde dehydrogenase superfamily. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/467795 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/10 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 31/26 (20130101) Original (OR) Class A61K 31/275 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/32 (20180101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20210402683 | HATWAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eagle Technology, LLC (Melbourne, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tukaram K. HATWAR (Penfield, New York); Rebecca BORRELLI (Rochester, New York); Steve OLIVER (Webster, New York) |
| ABSTRACT | The present invention is directed toward an additive manufacturing method for manufacturing silica-based structures that have a low linear cure shrinkage percentage and an ultra-low coefficient of thermal expansion. The structure may be constructed with a powder mixture that contains at least a first set of silica-based particles that are spherical and that have a first size, and a second set of submicron silica-based particles that are jagged, spherical, or both jagged and spherical. The silica-based powder mixture may be combined with a surfactant in order to create a slurry that can be used to create a 3D printed structure that has a low linear cure shrinkage percentage and an ultra-low coefficient of thermal expansion. |
| FILED | Wednesday, June 24, 2020 |
| APPL NO | 16/910577 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/1035 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/165 (20170801) Original (OR) Class B29C 64/314 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20210409193 — MODULATION-AGNOSTIC TRANSFORMATIONS USING UNITARY BRAID DIVISIONAL MULTIPLEXING (UBDM)
| US 20210409193 | ROBINSON |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rampart Communications, Inc. (Annapolis, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Brandon ROBINSON (Crownsville, Maryland) |
| ABSTRACT | A method for implementing a fast UBDM transform includes receiving a first, input vector via a processor, and partitioning the first vector to produce a magnitude vector and a sign vector. A second vector, including a modified magnitude vector and a modified sign vector, is generated by: applying a permutation to the magnitude vector to produce the modified magnitude vector, converting the sign vector, based on an algorithm, into an intermediate sign vector, and applying nonlinear layers to the intermediate sign vector. Each nonlinear layer includes a permutation, an S-box transformation, a diffusive linear operation and/or an Xor operation. Multiple linear layers are applied to the second vector to produce a third vector, the third vector being a transformed version of the first vector. A first signal representing the third vector is sent to at least one transmitter for transmission of a second signal representing the transformed data vector. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/916303 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0637 (20130101) Original (OR) Class H04L 27/2627 (20130101) H04L 2209/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, December 30, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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