FedInvent Patents

Patent Details for Tuesday, June 01, 2021 

This page was updated on Saturday, July 17, 2021 at 01:22 AM GMT

Department of Health and Human Services (HHS) 

US 11020005 Fitzgerald et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) Rehabilitation Institute of Chicago (Chicago, Illinois)
ASSIGNEE(S) Rehabilitation Institute of Chicago (Chicago, Illinois)
INVENTOR(S) Colleen M. Fitzgerald (LaGrange, Illinois);  Yasin Y. Dhaher (Mount Prospect, Illinois)
ABSTRACT Systems and methods for the diagnosis of chronic pain are disclosed. An algometer comprising a pressure sensor and electrode is disclosed. The algometer may be used to measure pressure applied by a clinician at a location on a patient's body, along with EMG signals emanating from the same location of the patient. Further, a pain trigger operable by the patient may be used in coordination with the algometer. Data from the algometer and pain trigger are transmitted to a computing device and display for rendering and analysis of patient data, leading to improved diagnosis.
FILED Friday, August 10, 2018
APPL NO 16/100928
ART UNIT 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0053 (20130101) Original (OR) Class
A61B 5/296 (20210101)
A61B 5/483 (20130101)
A61B 5/4827 (20130101)
A61B 5/6843 (20130101)
A61B 5/6885 (20130101)
A61B 2560/0425 (20130101)
A61B 2560/0462 (20130101)
A61B 2560/0468 (20130101)
A61B 2562/0247 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020006 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S) CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S) Lihong V. Wang (Arcadia, California);  Liming Nie (St. Louis, Missouri);  Xin Cai (St. Louis, Missouri);  Konstantin Maslov (Pasadena, California);  Mark A. Anastasio (St. Louis, Missouri);  Chao Huang (St. Louis, Missouri);  Robert W. Schoonover (St. Louis, Missouri)
ABSTRACT Systems and methods of reconstructing photoacoustic imaging data corresponding to a brain of a subject through a skull of a subject utilizing a reconstruction method that incorporates a spatial model of one or more acoustic properties of the brain and skull of the subject derived from an adjunct imaging dataset.
FILED Friday, October 18, 2013
APPL NO 14/436581
ART UNIT 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0035 (20130101)
A61B 5/0042 (20130101)
A61B 5/055 (20130101)
A61B 5/0095 (20130101) Original (OR) Class
A61B 5/725 (20130101)
A61B 5/4839 (20130101)
A61B 5/4848 (20130101)
A61B 5/7282 (20130101)
A61B 6/032 (20130101)
A61B 6/501 (20130101)
A61B 2576/026 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 31/005 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 29/2418 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020015 Rege et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) VASOPTIC MEDICAL, INC. (Baltimore, Maryland)
ASSIGNEE(S) Vasoptic Medical, Inc. (Baltimore, Maryland)
INVENTOR(S) Abhishek Rege (Baltimore, Maryland);  M. Jason Brooke (University Park, Maryland);  Kartikeya Murari (Calgary, Canada);  Yusi Liu (Rockville, Maryland)
ABSTRACT Examination of the structure and function of blood vessels is an important means of monitoring the health of a subject. Such examination can be important for disease diagnoses, monitoring specific physiologies over the short- or long-term, and scientific research. This disclosure describes technology and various embodiments of a system and method for imaging blood vessels and the intra-vessel blood flow, using at least laser speckle contrast imaging, with high speed so as to provide a rapid estimate of vessel-related or blood flow-related parameters.
FILED Friday, October 07, 2016
APPL NO 15/767057
ART UNIT 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 3/12 (20130101)
A61B 3/14 (20130101)
A61B 3/0075 (20130101)
A61B 3/0083 (20130101)
A61B 3/1208 (20130101)
A61B 3/1233 (20130101)
A61B 5/02 (20130101)
A61B 5/0066 (20130101)
A61B 5/0261 (20130101) Original (OR) Class
A61B 5/721 (20130101)
A61B 5/742 (20130101)
A61B 5/7207 (20130101)

Optical Elements, Systems, or Apparatus
G02B 27/48 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020020 Smith et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (Burlington, Vermont)
ASSIGNEE(S) University of Vermont and State Agricultural College (Burlington, Vermont)
INVENTOR(S) Bradford J. Smith (Burlington, Vermont);  Jason H. T. Bates (S. Burlington, Vermont)
ABSTRACT Systems and methods for determining lung recruitment/derecruitment dynamics of an individual are disclosed. The disclosed embodiments advantageously use variable ventilation of the individual to determine lung dynamics without necessitating additional, potentially harmful ventilation maneuvers.
FILED Monday, February 23, 2015
APPL NO 15/120902
ART UNIT 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/087 (20130101) Original (OR) Class
A61B 5/091 (20130101)
A61B 5/0816 (20130101)
A61B 5/4836 (20130101)
A61B 5/7278 (20130101)
A61B 5/7282 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 16/0069 (20140204)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020025 Datta et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Office of the Director (NIHOD)
APPLICANT(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S) Sandeep Robert Datta (Newton, Massachusetts);  Alexander Bame Wiltschko (Somerville, Massachusetts);  Matthew J. Johnson (Hillsborough, California)
ABSTRACT Systems and methods are disclosed to objectively identify sub-second behavioral modules in the three-dimensional (3D) video data that represents the motion of a subject. Defining behavioral modules based upon structure in the 3D video data itself—rather than using a priori definitions for what should constitute a measurable unit of action—identifies a previously-unexplored sub-second regularity that defines a timescale upon which behavior is organized, yields important information about the components and structure of behavior, offers insight into the nature of behavioral change in the subject, and enables objective discovery of subtle alterations in patterned action. The systems and methods of the invention can be applied to drug or gene therapy classification, drug or gene therapy screening, disease study including early detection of the onset of a disease, toxicology research, side-effect study, learning and memory process study, anxiety study, and analysis in consumer behavior.
FILED Tuesday, October 11, 2016
APPL NO 15/767544
ART UNIT 2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/00 (20130101)
A61B 5/1123 (20130101)
A61B 5/1128 (20130101) Original (OR) Class
A61B 5/7267 (20130101)
A61B 2503/40 (20130101)
A61B 2503/42 (20130101)
A61B 2576/00 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/209 (20130101)
G06K 9/00335 (20130101)
G06K 9/6247 (20130101)
G06K 9/6297 (20130101)

Image Data Processing or Generation, in General
G06T 7/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020054 Pritchard et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
ASSIGNEE(S) The Florida State University Research Foundation, Inc. (Tallahassee, Florida)
INVENTOR(S) Emily Pritchard (Tallahassee, Florida);  Mina-Michael Barsoum (Tallahassee, Florida);  Judy Delp (Tallahassee, Florida);  Josh Maraj (Tallahassee, Florida);  Kazuki Hotta (Niigata, Japan)
ABSTRACT Splints for diagnostic and/or therapeutic purposes are disclosed. In one aspect, the present disclosure relates to a splint system for diagnostic and/or therapeutic functions for a patient with a vascular impairment. In one embodiment, the splint system includes a splint having: a leg supporting portion and a foot supporting portion, that are configured to support and secure the leg and foot of the patient; a locally and/or remotely controllable portion for setting a dorsiflexion angle of the foot of the patient, including electrical and/or mechanical controls and one or more actuators for setting of the dorsiflexion angle, for providing treatment to improve vascular function; and a plurality of physiological parameter sensors for measuring physiological parameters of the leg and/or foot of the patient, wherein the physiological parameters are associated with vascular function in the leg and/or foot of the patient.
FILED Thursday, November 15, 2018
APPL NO 16/192423
ART UNIT 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/026 (20130101)
A61B 5/0295 (20130101)
A61B 5/1036 (20130101)
A61B 5/1071 (20130101)
A61B 5/02055 (20130101)
A61B 5/02233 (20130101)
A61B 5/02416 (20130101)
A61B 5/4836 (20130101)
A61B 5/6812 (20130101) Original (OR) Class
A61B 5/6829 (20130101)
A61B 5/14552 (20130101)
A61B 7/04 (20130101)
A61B 8/02 (20130101)
A61B 8/04 (20130101)
A61B 8/06 (20130101)
A61B 8/461 (20130101)
A61B 8/488 (20130101)
A61B 8/4209 (20130101)
A61B 8/4227 (20130101)
A61B 8/4427 (20130101)
A61B 8/5223 (20130101)

Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 5/0127 (20130101)
A61F 5/0585 (20130101)
A61F 2005/0155 (20130101)
A61F 2005/0167 (20130101)

Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body
A61H 1/0266 (20130101)
A61H 2201/165 (20130101)
A61H 2201/0173 (20130101)
A61H 2201/0192 (20130101)
A61H 2201/1215 (20130101)
A61H 2201/1642 (20130101)
A61H 2201/5007 (20130101)
A61H 2201/5025 (20130101)
A61H 2201/5069 (20130101)
A61H 2201/5097 (20130101)
A61H 2205/106 (20130101)
A61H 2209/00 (20130101)
A61H 2230/00 (20130101)
A61H 2230/30 (20130101)
A61H 2230/50 (20130101)
A61H 2230/207 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020077 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York)
ASSIGNEE(S) Rensselaer Polytechnic Institute (Troy, New York)
INVENTOR(S) Ge Wang (Loudonville, New York);  Yan Xi (Troy, New York);  Wenxiang Cong (Albany, New York);  Jun Zhao (Shanghai, China PRC)
ABSTRACT Novel and advantageous systems and method for obtaining and/or reconstructing simultaneous computed tomography (CT)-magnetic resonance imaging (MRI) images are provided. Structural coupling (SC) and compressive sensing (CS) techniques can be combined to unify and improve CT and MRI reconstruction. A bidirectional image estimation method can be used to connect images from different modalities, with CT and MRI data serving as prior knowledge to each other to produce better CT and MRI image quality than would be realized with individual reconstruction.
FILED Wednesday, September 14, 2016
APPL NO 15/759326
ART UNIT 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0035 (20130101)
A61B 5/055 (20130101)
A61B 6/032 (20130101)
A61B 6/035 (20130101)
A61B 6/4417 (20130101)
A61B 6/5205 (20130101)
A61B 6/5247 (20130101) Original (OR) Class

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/3815 (20130101)
G01R 33/4812 (20130101)
G01R 33/5608 (20130101)

Image Data Processing or Generation, in General
G06T 11/006 (20130101)
G06T 2211/424 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020404 Haudenschild et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) The Regents Of The University Of California, Davis (Oakland, California)
INVENTOR(S) Dominik Haudenschild (Davis, California);  Jasper Yik (Elk Grove, California)
ABSTRACT Provided are methods for the combined use of cyclin-dependent kinase 9 (CDK9) inhibitors and bromodomain containing 4 (BRD4) inhibitors to reduce, inhibit and/or prevent cartilage degradation and systemic traumatic inflammation. A combination of CDK9 inhibitors and BRD4 inhibitors can be used to reduce, inhibit and/or prevent cartilage degradation and loss of cartilage viability during allograft storage. A combination of CDK9 inhibitors and BRD4 inhibitors can be used as a post-injury intervention treatment to reduce, inhibit and/or prevent the acute cellular responses that lead to future cartilage degradation and osteoarthritis.
FILED Thursday, May 23, 2019
APPL NO 16/421218
ART UNIT 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/00 (20130101)
A61K 31/352 (20130101)
A61K 31/352 (20130101)
A61K 31/445 (20130101)
A61K 31/551 (20130101)
A61K 31/551 (20130101)
A61K 31/5513 (20130101) Original (OR) Class
A61K 31/5513 (20130101)
A61K 45/06 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020422 McKew et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Rockville, Maryland)
ASSIGNEE(S)
INVENTOR(S) John McKew (Poolesville, Maryland);  Wei Zheng (Potomac, Maryland);  Miao Xu (Hangzhou, China PRC);  Manju Swaroop (Gaithersburg, Maryland);  Juan J. Marugan (Gaithersburg, Maryland)
ABSTRACT The invention provides for methods of treating lysosomal storage disorders and/or reduction of non-cholesterol lipids, using cyclodextrin compounds, including in combination with other therapeutics, including vitamin E.
FILED Monday, June 12, 2017
APPL NO 15/620753
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/355 (20130101)
A61K 31/355 (20130101)
A61K 31/724 (20130101) Original (OR) Class
A61K 31/724 (20130101)
A61K 45/06 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)

Polysaccharides; Derivatives Thereof
C08B 37/0012 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/92 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020426 Poelzing et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia)
ASSIGNEE(S) VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia)
INVENTOR(S) Steven Poelzing (Roanoke, Virginia);  David Ryan King (Roanoke, Virginia)
ABSTRACT Described herein are low sodium formulations. In some embodiments, the low sodium formulations can contain an effective concentration of sodium and an effective concentration of calcium. The low sodium formulations can be provided as combination kit that can include, in some embodiments, a low sodium formulation and a defibrillation device. Also described herein are methods of administering the low sodium formulation to a subject in need thereof and performing cardiac resuscitation and/or defibrillation on the subject in need thereof.
FILED Thursday, November 08, 2018
APPL NO 16/184291
ART UNIT 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle
A61J 1/10 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 33/00 (20130101)
A61K 33/06 (20130101) Original (OR) Class
A61K 33/08 (20130101)
A61K 33/10 (20130101)
A61K 33/14 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/3904 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020430 Ahmed et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Emory University (Atlanta, Georgia);  St. Jude Children's Hospital, Inc. (Memphis, Tennessee)
ASSIGNEE(S) Emory University (Atlanta, Georgia);  St. Jude Children's Research Hospital, Inc. (Memphis, Tennessee)
INVENTOR(S) Rafi Ahmed (Atlanta, Georgia);  Benjamin Youngblood (Decatur, Georgia)
ABSTRACT This disclosure relates to the genetic modification of DNMT3A gene in immune cells. In certain embodiments, the modified immune cells may be used in adoptive T cells therapies to enhance immune responses against cancer or chronic infections. In certain embodiments, the disclosure relates to deleting, changing, or inserting nucleotides within the DNMT3A gene in immune cells, e.g., human CD8 T cells, such that the DNMT3A gene product does not function for methylation. In certain embodiments, modification of the DNMT3A gene provides an improvement in antigen-specific T cells functions and/or an enhancement of the longevity of the cells.
FILED Friday, November 04, 2016
APPL NO 15/773783
ART UNIT 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)
A61P 35/00 (20180101)

Peptides
C07K 14/005 (20130101)
C07K 14/70596 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101)
C12N 5/0638 (20130101)
C12N 9/1007 (20130101)
C12N 2510/00 (20130101)
C12N 2740/16033 (20130101)
C12N 2740/16111 (20130101)

Enzymes
C12Y 201/01037 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020443 Esteves et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S) University of Massachusetts (Boston, Massachusetts)
INVENTOR(S) Miguel Sena Esteves (Westford, Massachusetts);  Cara Weismann (Worcester, Massachusetts);  Diane Golebiowski (Lexington, Massachusetts);  Lorelei Stoica (Worcester, Massachusetts)
ABSTRACT Aspects of the invention relate to recombinant adeno-associated viruses (rAAVs). In some aspects, the rAAVs comprise artificial genetic regulatory elements that modulate transgene expression. In some aspects, the disclosure relates to the treatment of lysosomal storage disorders.
FILED Wednesday, April 20, 2016
APPL NO 15/567847
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/761 (20130101) Original (OR) Class
A61K 48/00 (20130101)
A61K 48/0058 (20130101)
A61K 48/0066 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)
A61P 43/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/2402 (20130101)
C12N 9/2471 (20130101)
C12N 15/86 (20130101)
C12N 15/861 (20130101)
C12N 2750/14143 (20130101)

Enzymes
C12Y 302/01023 (20130101)
C12Y 302/01052 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020456 Hunter et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania)
ASSIGNEE(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S) Christopher A. Hunter (Philadelphia, Pennsylvania);  Alejandro Villarino (Philadelphia, Pennsylvania)
ABSTRACT The inventive subject matter relates to novel methods for modulating an immune response in an animal, which comprises administering to said animal an effective amount of an agent that increases IL-27R/WSX-1 activity. Further, the inventive subject matter relates to pharmaceutical compositions comprising an effective amount of an agent that increases IL-27R/WSX-1 activity.
FILED Tuesday, January 30, 2018
APPL NO 15/883879
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/20 (20130101) Original (OR) Class
A61K 38/208 (20130101)
A61K 2039/505 (20130101)

Peptides
C07K 16/2866 (20130101)
C07K 2317/76 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020463 Conklin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone (San Francisco, California);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The J. David Gladstone Institutes (San Francisco, California);  The Regents of the University of California (Oakland, California)
INVENTOR(S) Bruce R. Conklin (San Francisco, California);  Luke Judge (San Francisco, California)
ABSTRACT The present invention provides assays and compositions to identify the risk of toxicity in a patient population with genotypic variations in specific proteins and/or protein complexes within the patient population.
FILED Monday, August 08, 2016
APPL NO 15/750495
ART UNIT 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/00 (20130101)
A61K 38/57 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0658 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/24 (20130101)
C12Q 1/6881 (20130101)
C12Q 2600/106 (20130101)
C12Q 2600/142 (20130101)
C12Q 2600/156 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5014 (20130101)
G01N 33/5061 (20130101)
G01N 33/5073 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020482 Francis et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S) THE UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
INVENTOR(S) J. Nicholas Francis (Salt Lake City, Utah);  Joseph S. Redman (Salt Lake City, Utah);  Michael S. Kay (Salt Lake City, Utah)
ABSTRACT Disclosed herein are compositions and methods for inhibiting viral entry.
FILED Wednesday, August 21, 2019
APPL NO 16/547383
ART UNIT 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/08 (20130101)
A61K 38/10 (20130101)
A61K 45/06 (20130101) Original (OR) Class
A61K 47/60 (20170801)
A61K 47/542 (20170801)
A61K 47/554 (20170801)
A61K 47/643 (20170801)

Peptides
C07K 7/06 (20130101)
C07K 7/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020488 Crews et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (Oakland, California);  Henry Ford Health System (Detroit, Michigan)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  Henry Ford Health System (Detroit, Michigan)
INVENTOR(S) Phillip Crews (Santa Cruz, California);  Frederick A. Valeriote (Washington, Michigan);  Sheng Lin (Beijing, China PRC);  Erin P. McCauley (Santa Cruz, California);  Nicholas Lorig-Roach (Santa Cruz, California);  Karen Tenney (Santa Cruz, California)
ABSTRACT Provided are pyrroloquinolin compounds of formula (1) or (II). In certain aspects, the pyrroloquinolin compounds are therapeutic, e.g., for treating a cell proliferative disorder. Also provided are conjugates that include the pyrroloquinolin compounds of the present disclosure. Compositions, e.g., pharmaceutical compositions, that include the pyrroloquinolin compounds and conjugates of the present disclosure are also provided. Further provided are therapeutic methods involving the administration of the pyrroloquinolin compounds, conjugates or compositions of the present disclosure. Kits that include the pyrroloquinolin compounds, conjugates or compositions are also provided.
FILED Tuesday, March 13, 2018
APPL NO 16/493690
ART UNIT 1625 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/437 (20130101)
A61K 47/6803 (20170801) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 471/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020489 Govindan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Immunomedics, Inc. (Morris Plains, New Jersey)
ASSIGNEE(S) Immunomedics, Inc. (Morris Plains, New Jersey)
INVENTOR(S) Serengulam V. Govindan (Summit, New Jersey);  Sung-Ju Moon (New Providence, New Jersey);  David M. Goldenberg (Mendham, New Jersey)
ABSTRACT The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
FILED Monday, April 06, 2020
APPL NO 16/841345
ART UNIT 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4745 (20130101)
A61K 45/06 (20130101)
A61K 47/6803 (20170801) Original (OR) Class
A61K 47/6841 (20170801)
A61K 47/6849 (20170801)
A61K 47/6851 (20170801)
A61K 47/6853 (20170801)
A61K 47/6855 (20170801)
A61K 47/6857 (20170801)
A61K 47/6861 (20170801)
A61K 47/6889 (20170801)
A61K 2039/505 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/10 (20130101)

Heterocyclic Compounds
C07D 491/22 (20130101)

Peptides
C07K 16/18 (20130101)
C07K 16/30 (20130101)
C07K 16/303 (20130101)
C07K 16/1063 (20130101)
C07K 16/2803 (20130101)
C07K 16/2833 (20130101)
C07K 16/2863 (20130101)
C07K 16/2887 (20130101)
C07K 16/3046 (20130101)
C07K 16/3076 (20130101)
C07K 16/3092 (20130101)
C07K 2317/21 (20130101)
C07K 2317/24 (20130101)
C07K 2317/31 (20130101)
C07K 2317/40 (20130101)
C07K 2317/52 (20130101)
C07K 2317/53 (20130101)
C07K 2317/94 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020494 Peterson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) CROWN BIOSCIENCE INC. (TAICANG) (Taicang, China PRC)
ASSIGNEE(S) CROWN BIOSCIENCE INC. (TAICANG) (Jiangsu, China PRC)
INVENTOR(S) Richard Peterson (Indianapolis, Indiana);  Charles Van Jackson (Greenfield, Indiana);  Gao Sun (Shanghai, China PRC);  Guodong Zhang (Taicang, China PRC);  Yixin (Jim) Wang (Lafayette, California)
ABSTRACT The present disclosure provides non-human animal models of non-alcoholic fatty liver disease (NAFLD). Also provided are methods for producing the non-human animal models and uses of the non-human animal models to screen and evaluate agents for treating or preventing NAFLD.
FILED Thursday, June 21, 2018
APPL NO 16/013953
ART UNIT 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/027 (20130101)
A01K 2207/25 (20130101)
A01K 2227/105 (20130101)
A01K 2267/035 (20130101)
A01K 2267/0362 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0008 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020497 Steinmetz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S) Nicole Steinmetz (San Diego, California);  Michael Bruckman (Cleveland, Ohio)
ABSTRACT A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
FILED Tuesday, October 02, 2018
APPL NO 16/149828
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/1884 (20130101)
A61K 49/1896 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2770/00031 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020524 Borkholder et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) David A. Borkholder (Canandaigua, New York);  Farzad Forouzandeh (Rochester, New York);  Robert Nash Carter (Honeoye Falls, New York);  Denis Roger Cormier (Pittsford, New York);  Joseph P. Walton (Tampa, Florida);  Robert Dana Frisina (Tampa, Florida)
ASSIGNEE(S) University of South Florida (Tampa, Florida);  Rochester Institute of Technology (Rochester, New York)
INVENTOR(S) David A. Borkholder (Canandaigua, New York);  Farzad Forouzandeh (Rochester, New York);  Robert Nash Carter (Honeoye Falls, New York);  Denis Roger Cormier (Pittsford, New York);  Joseph P. Walton (Tampa, Florida);  Robert Dana Frisina (Tampa, Florida)
ABSTRACT In one embodiment, a peristaltic micropump comprising a substrate having a first side and a second side, a microtube that extends across the first side of the substrate, and multiple pump actuators formed on the first side of the substrate and positioned adjacent to the microtube at discrete, spaced positions along the length of the microtube, wherein the micropump is configured to sequentially actuate the pump actuators so as to create peristaltic action that drives fluid contained in the microtube along the length of the tube.
FILED Monday, February 20, 2017
APPL NO 15/437356
ART UNIT 3783 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC
Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/14228 (20130101)
A61M 5/14276 (20130101) Original (OR) Class
A61M 2005/14208 (20130101)
A61M 2205/50 (20130101)
A61M 2205/0216 (20130101)
A61M 2205/0244 (20130101)
A61M 2205/3368 (20130101)
A61M 2205/3523 (20130101)
A61M 2205/3673 (20130101)
A61M 2205/8206 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020593 Brown
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania);  ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S) University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania);  Arizona Board of Regents Acting for and on Behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S) Christopher A. Brown (Pittsburgh, Pennsylvania)
ABSTRACT A method of enhancing binaural representation for a subject includes receiving a first signal and a second signal in response to a plurality of sound sources, generating a number of estimated interaural time differences using the first signal and the second signal, converting each of the number of estimated interaural time differences to a corresponding interaural level difference, using one or more of the corresponding interaural level differences to generate an adjusted first signal, and using the adjusted first signal to generate a number of signals delivered to the subject for enhancing the hearing of the subject.
FILED Friday, July 15, 2016
APPL NO 15/211173
ART UNIT 2651 — Videophones and Telephonic Communications
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/36038 (20170801) Original (OR) Class

Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems
H04R 25/43 (20130101)
H04R 25/505 (20130101)
H04R 25/552 (20130101)
H04R 2430/03 (20130101)

Stereophonic Systems
H04S 2420/01 (20130101)
H04S 2420/07 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020601 Shusterman
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Vladimir Shusterman (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Vladimir Shusterman (Pittsburgh, Pennsylvania)
ABSTRACT This accessory adapts external cardiac defibrillation systems to enable safe defibrillation, pacing, and cardioversion inside the MRI bore with minimal effect on MR image quality. Commercially available external defibrillators are not designed to work in the MRI environment. An MR-compatible defibrillator is needed to safely perform cardiovascular MRI, in particular MR-guided interventional cardiovascular procedures, such as cardiac electrophysiology studies and cardiac catheterization. This accessory includes nonmagnetic defibrillator housing with MRI safety features, provides interface for MRI-compatible physiological monitoring, and optimizes defibrillator operation for the MRI environment. The accessory may include MRI-compatible modules for monitoring/recording electrocardiogram, blood pressure, pulse oximetry, and other physiological signals. It may also include a wireless transmitter and at least one module for electrical energy generation and/or stimulation.
FILED Wednesday, April 25, 2018
APPL NO 15/963095
ART UNIT 3649 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/002 (20130101)
A61B 5/0006 (20130101)
A61B 5/021 (20130101)
A61B 5/0024 (20130101)
A61B 5/053 (20130101)
A61B 5/055 (20130101)
A61B 5/0205 (20130101)
A61B 5/0263 (20130101)
A61B 5/318 (20210101)
A61B 5/369 (20210101)
A61B 5/389 (20210101)
A61B 5/7203 (20130101)
A61B 5/7217 (20130101)
A61B 5/7221 (20130101)
A61B 5/7225 (20130101)
A61B 5/7282 (20130101)
A61B 5/14551 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/3625 (20130101)
A61N 1/3718 (20130101)
A61N 1/3904 (20170801) Original (OR) Class
A61N 1/3931 (20130101)
A61N 1/3993 (20130101)
A61N 1/36031 (20170801)
A61N 1/36139 (20130101)

Transmission Systems for Measured Values, Control or Similar Signals
G08C 17/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020610 Brezinski et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) Little Sparrows Technologies LLC (Winchester, Massachusetts)
ASSIGNEE(S) LITTLE SPARROWS TECHNOLOGIES INC. (Winchester, Massachusetts)
INVENTOR(S) Donna Brezinski (Winchester, Massachusetts);  Gary Gilbert (Winchester, Massachusetts)
ABSTRACT Disclosed is a positioning device for use in a compound portable phototherapy device to contain and enhance therapeutic treatment to a subject. The positioning device comprises an inner surface composed of a non-porous, light reflective material, as well as an outer surface that may be opaque. Use of the positioning device in conjunction with a phototherapy device secures advantages of increased incident light directed on a subject and a controlled thermal environment for the subject. The positioning device may be portable and may be pliable, capable of being rolled or compressed. The positioning device may optionally include a visor, venting, and stabilizing cushioning. The positioning device may optionally include a thermal regulation element.
FILED Wednesday, June 29, 2016
APPL NO 15/739319
ART UNIT 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 7/08 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/0621 (20130101) Original (OR) Class
A61N 2005/0638 (20130101)
A61N 2005/0663 (20130101)
A61N 2005/0666 (20130101)
A61N 2005/0667 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020617 Konofagou et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Elisa E. Konofagou (New York, New York);  Matthew Downs (New York, New York);  Stephen Lee (New York, New York);  Min Gon Kim (Fort Lee, New Jersey);  Hermes Arytto Salles Kamimura (New York, New York)
ABSTRACT Techniques for modulating peripheral nerves using focused ultrasound (FUS) are provided. Methods include locating a peripheral nerve in a subject using an imaging probe, providing a FUS having one or more ultrasound parameters to a location on the peripheral nerve, and modulating the peripheral nerve. The methods can further include eliciting and measuring a physiological response from the FUS modulation, generating tissue deformation in the vicinity of the FUS modulation, and imaging the nerve and the tissue deformation simultaneously with FUS modulation. Systems for use in the modulation of peripheral nerves are also provided.
FILED Friday, February 01, 2019
APPL NO 16/265827
ART UNIT 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/01 (20130101)
A61B 5/024 (20130101)
A61B 5/369 (20210101)
A61B 5/389 (20210101)
A61B 5/4836 (20130101)
A61B 8/14 (20130101)
A61B 8/42 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 7/00 (20130101) Original (OR) Class
A61N 7/02 (20130101)
A61N 2007/0026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020730 Hoveyda et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Trustees of Boston College (Chestnut Hill, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Trustees of Boston College (Chestnut Hill, Massachusetts)
INVENTOR(S) Amir H. Hoveyda (Lincoln, Massachusetts);  Ming Joo Koh (Chestnut Hill, Massachusetts);  Thach T. Nguyen (Newton, Massachusetts);  Richard R. Schrock (Winchester, Massachusetts);  Jakub Hyvl (Honolulu, Hawaii)
ABSTRACT The present disclosure provides compounds, compositions, and methods for preparing alkenyl halides and/or haloalkyl-substituted olefins with Z-selectivity. The methods are particularly useful for preparing alkenyl fluorides such as CF3-substituted olefins by means of cross-metathesis reactions using halogen-containing molybdenum and tungsten complexes.
FILED Friday, July 14, 2017
APPL NO 16/317452
ART UNIT 1625 — Organic Chemistry
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 31/181 (20130101)
B01J 31/1805 (20130101)
B01J 31/2208 (20130101) Original (OR) Class
B01J 2231/543 (20130101)
B01J 2531/64 (20130101)

Acyclic or Carbocyclic Compounds
C07C 17/37 (20130101)
C07C 41/18 (20130101)
C07C 67/475 (20130101)
C07C 209/68 (20130101)
C07C 319/20 (20130101)

Heterocyclic Compounds
C07D 209/08 (20130101)
C07D 209/48 (20130101)
C07D 211/18 (20130101)
C07D 211/56 (20130101)
C07D 307/79 (20130101)
C07D 333/54 (20130101)

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 7/083 (20130101)
C07F 11/00 (20130101)
C07F 17/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020736 Abate et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Adam R. Abate (San Francisco, California);  Adam R. Sciambi (San Francisco, California);  Russell Cole (San Francisco, California);  Zev Jordan Gartner (Pacifica, California)
ABSTRACT Methods for delivering discrete entities including, e.g., cells, media or reagents to substrates are provided. In certain aspects, the methods include manipulating and/or analyzing qualities of the entities or biological components thereof. In some embodiments, the methods may be used to create arrays of microenvironments and/or for two and three-dimensional printing of tissues or structures. Systems and devices for practicing the subject methods are also provided.
FILED Tuesday, August 27, 2019
APPL NO 16/552982
ART UNIT 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/0268 (20130101) Original (OR) Class
B01L 3/502784 (20130101)
B01L 2200/0673 (20130101)
B01L 2300/0645 (20130101)
B01L 2300/0829 (20130101)
B01L 2300/0864 (20130101)
B01L 2400/086 (20130101)
B01L 2400/0427 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1459 (20130101)
G01N 15/1463 (20130101)
G01N 15/1484 (20130101)
G01N 2015/149 (20130101)
G01N 2015/1006 (20130101)
G01N 2035/1034 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021427 Yu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S) THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S) Jin-Quan Yu (San Diego, California);  Pengxiang Shen (San Diego, California)
ABSTRACT The invention includes procedures for stereoselective β-acylation of carboxylic acids having a β-carbon atom. For example, stereoselective acylation procedures include the following reactions: (I)
FILED Wednesday, April 17, 2019
APPL NO 15/733763
ART UNIT 1626 — Organic Chemistry
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 27/232 (20130101)
B01J 31/2213 (20130101)

General Methods of Organic Chemistry; Apparatus Therefor
C07B 2200/07 (20130101)

Acyclic or Carbocyclic Compounds
C07C 51/353 (20130101) Original (OR) Class
C07C 67/343 (20130101)
C07C 201/12 (20130101)
C07C 253/30 (20130101)

Heterocyclic Compounds
C07D 209/48 (20130101)
C07D 209/49 (20130101)
C07D 307/54 (20130101)
C07D 333/24 (20130101)

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 9/4071 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021435 Booth
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
National Institute of Mental Health (NIMH)
APPLICANT(S) Northeastern University (Boston, Massachusetts)
ASSIGNEE(S) Northeastern University (Boston, Massachusetts)
INVENTOR(S) Raymond G. Booth (Arlington, Massachusetts)
ABSTRACT This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor. The compositions include chiral tetrahydronaphthalen-2-amine derivatives. Accordingly, the present invention provides for compositions and methods that agonize or antagonize one or more serotonin receptors and which find Use in the treatment of various neuropsychiatric diseases or disorders including, without limitation, autism spectrum disorder (ASD) or associated symptoms.
FILED Tuesday, May 19, 2015
APPL NO 15/311905
ART UNIT 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/135 (20130101)

Acyclic or Carbocyclic Compounds
C07C 211/42 (20130101) Original (OR) Class
C07C 215/64 (20130101)
C07C 217/74 (20130101)
C07C 2601/08 (20170501)
C07C 2602/10 (20170501)

Heterocyclic Compounds
C07D 217/04 (20130101)
C07D 307/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021447 Lohrman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Oregon (Eugene, Oregon);  University of Montana (Missoula, Montana)
ASSIGNEE(S) University of Oregon (Eugene, Oregon);  University of Montana (Missoula, Montana)
INVENTOR(S) Jessica Lohrman (Eugene, Oregon);  Darren W. Johnson (Eugene, Oregon);  Michael M. Haley (Eugene, Oregon);  Orion B. Berryman (Missoula, Montana);  Asia M. Riel (Missoula, Montana);  Daniel A. Decato (Missoula, Montana)
ABSTRACT A compound, or a protonate or salt thereof, of formula I:
    • wherein Y is aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
    • n is 1 or 2;
    • each R10 is independently alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, aryl, substituted aryl, cyano, hydroxyl, carbonylamino, aminocarbonyl, acyl, sulfonyl, or substituted sulfonyl;
    • a is 0 to 4;

is an aryl or heteroaryl ring; and
    • each R is independently halogen, carbonylamino, sulfonamide, carboxylic acid or hydrogen, provided at least one R is a halogen; and
    • provided that if Y is

are not
respectively.
FILED Wednesday, May 01, 2019
APPL NO 16/401037
ART UNIT 1625 — Organic Chemistry
CURRENT CPC
Heterocyclic Compounds
C07D 213/22 (20130101)
C07D 213/90 (20130101)
C07D 233/56 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6428 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021450 Pomper et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S) The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S) Martin G. Pomper (Baltimore, Maryland);  Ronnie C. Mease (Fairfax, Virginia);  Ying Chen (Timonium, Maryland);  Sangeeta Ray (Ellicott City, Maryland)
ABSTRACT Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.
FILED Monday, March 16, 2020
APPL NO 16/820052
ART UNIT 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0032 (20130101)
A61K 49/0052 (20130101)
A61K 51/044 (20130101)
A61K 51/0421 (20130101)
A61K 51/0446 (20130101)
A61K 51/0453 (20130101)
A61K 51/0472 (20130101)

Heterocyclic Compounds
C07D 209/12 (20130101)
C07D 209/14 (20130101)
C07D 209/24 (20130101)
C07D 213/04 (20130101)
C07D 249/04 (20130101)
C07D 255/02 (20130101)
C07D 257/02 (20130101) Original (OR) Class
C07D 311/14 (20130101)
C07D 311/20 (20130101)
C07D 311/82 (20130101)

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 5/027 (20130101)
C07F 13/005 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5091 (20130101)
G01N 2800/342 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021453 Cisar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) Lundbeck La Jolla Research Center, Inc. (San Diego, California);  THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
ASSIGNEE(S) LUNDBECK LA JOLLA RESEARCH CENTER, INC. (San Diego, California);  THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California)
INVENTOR(S) Justin S. Cisar (San Diego, California);  Cheryl A. Grice (Encinitas, California);  Todd K. Jones (Solana Beach, California);  Micah J. Niphakis (San Diego, California);  Jae Won Chang (San Diego, California);  Kenneth M. Lum (San Diego, California);  Benjamin F. Cravatt (San Diego, California)
ABSTRACT This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for a method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
FILED Tuesday, December 17, 2019
APPL NO 16/717813
ART UNIT 1624 — Organic Chemistry
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/22 (20180101)

Acyclic or Carbocyclic Compounds
C07C 271/10 (20130101)
C07C 271/12 (20130101)

Heterocyclic Compounds
C07D 205/04 (20130101)
C07D 207/09 (20130101)
C07D 207/14 (20130101)
C07D 213/38 (20130101)
C07D 213/40 (20130101)
C07D 213/55 (20130101)
C07D 215/42 (20130101)
C07D 215/46 (20130101)
C07D 231/12 (20130101)
C07D 231/16 (20130101)
C07D 231/56 (20130101)
C07D 241/04 (20130101)
C07D 261/08 (20130101)
C07D 263/32 (20130101)
C07D 271/06 (20130101)
C07D 295/26 (20130101)
C07D 295/205 (20130101) Original (OR) Class
C07D 307/79 (20130101)
C07D 317/46 (20130101)
C07D 317/58 (20130101)
C07D 401/04 (20130101)
C07D 401/10 (20130101)
C07D 403/10 (20130101)
C07D 405/14 (20130101)
C07D 407/06 (20130101)
C07D 413/06 (20130101)
C07D 413/10 (20130101)
C07D 471/04 (20130101)
C07D 471/10 (20130101)
C07D 487/04 (20130101)
C07D 491/107 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021469 Becker et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) LOYOLA UNIVERSITY OF CHICAGO (Chicago, Illinois);  Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S) LOYOLA UNIVERSITY OF CHICAGO (Chicago, Illinois);  Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S) Daniel Paul Becker (Glenview, Illinois);  Tahirah K. Heath (Chicago, Illinois);  Cory Reidl (Franklin Grove, Illinois);  Walter Fast (Austin, Texas)
ABSTRACT Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-β-lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the indoline sulfonamide compounds disclosed herein.
FILED Wednesday, July 17, 2019
APPL NO 16/514921
ART UNIT 1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Heterocyclic Compounds
C07D 209/08 (20130101)
C07D 209/10 (20130101)
C07D 401/12 (20130101)
C07D 403/12 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021471 Teng et al.
FUNDED BY
Department of Health and Human Services (HHS)
Assistant Secretary for Preparedness and Response (ASPR)
APPLICANT(S) FORGE THERAPEUTICS, INC. (San Diego, California)
ASSIGNEE(S) FORGE THERAPEUTICS, INC. (San Diego, California)
INVENTOR(S) Min Teng (San Diego, California);  Baskar Nammalwar (San Diego, California);  Konstantin Taganov (San Diego, California);  Xiaoming Li (San Diego, California);  David T. Puerta (San Diego, California)
ABSTRACT Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.
FILED Wednesday, May 09, 2018
APPL NO 16/612308
ART UNIT 1625 — Organic Chemistry
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Heterocyclic Compounds
C07D 309/40 (20130101)
C07D 405/06 (20130101)
C07D 405/12 (20130101)
C07D 405/14 (20130101) Original (OR) Class
C07D 407/04 (20130101)
C07D 413/10 (20130101)
C07D 471/04 (20130101)
C07D 487/04 (20130101)
C07D 493/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021488 Guzman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
Office of the Director (NIHOD)
APPLICANT(S) BioVentures, LLC (Little Rock, Arkansas);  Cornell University (Ithaca, New York);  New York Botanical Garden (Bronx, New York)
ASSIGNEE(S) Board of Trustees of the University of Arkansas (Little Rock, Arkansas);  BioVentures, LLC (Little Rock, Arkansas);  Cornell University (Ithaca, New York);  New York Botanical Garden (Bronx, New York)
INVENTOR(S) Monica L. Guzman (Ithaca, New York);  Cesar M. Compadre (Little Rock, Arkansas);  Paola E. Ordonez (Little Rock, Arkansas);  Mariano Martinez (Little Rock, Arkansas);  Michael J. Balick (Bronx, New York);  Darin E. Jones (Little Rock, Arkansas);  Flavio G. Gaudio (Ithaca, New York)
ABSTRACT The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.
FILED Friday, July 26, 2019
APPL NO 16/523687
ART UNIT 1657 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Heterocyclic Compounds
C07D 307/93 (20130101)
C07D 493/04 (20130101)
C07D 493/08 (20130101)
C07D 493/10 (20130101) Original (OR) Class
C07D 493/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021502 Eberwine et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
INVENTOR(S) James Eberwine (Philadelphia, Pennsylvania);  Ivan J. Dmochowski (Philadelphia, Pennsylvania);  Sean B. Yeldell (Philadelphia, Pennsylvania);  Julianne C. Griepenburg (Philadelphia, Pennsylvania);  Teresa L. Rapp (Philadelphia, Pennsylvania);  Jennifer M. Singh (Havertown, Pennsylvania);  Jai-Yoon Sul (Cherry Hill, New Jersey);  Jaehee Lee (Wynnewood, Pennsylvania)
ABSTRACT Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense oligonucleotide, which when uncaged hybridizes to a target nucleic acid molecule.
FILED Tuesday, August 04, 2015
APPL NO 15/501073
ART UNIT 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 35/004 (20130101)
B01J 2531/821 (20130101)

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 15/0053 (20130101) Original (OR) Class

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 23/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 13/00 (20130101)
C12N 15/113 (20130101)
C12N 2310/11 (20130101)
C12N 2310/32 (20130101)
C12N 2310/351 (20130101)
C12N 2310/531 (20130101)
C12N 2310/3233 (20130101)
C12N 2310/3517 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6818 (20130101)
C12Q 1/6823 (20130101)
C12Q 1/6825 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021506 Oscarson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Regents of the University of California (Oakland, California);  University College Dublin (Dublin, Ireland)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  University College Dublin (Dublin, Ireland)
INVENTOR(S) Stefan Oscarson (Blackrock, Ireland);  John Vincent Fahy (San Francisco, California);  Shaopeng Yuan (San Francisco, California);  Stephen Carrington (Roundwood, Ireland)
ABSTRACT There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.
FILED Friday, November 22, 2019
APPL NO 16/692300
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/70 (20130101)
A61K 31/702 (20130101)
A61K 31/7016 (20130101)
A61K 31/7028 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 11/00 (20180101)
A61P 11/04 (20180101)
A61P 11/06 (20180101)
A61P 11/12 (20180101)
A61P 43/00 (20180101)

Heterocyclic Compounds
C07D 309/10 (20130101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 5/04 (20130101)
C07H 13/04 (20130101)
C07H 15/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021517 Nguyen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Quyen T. Nguyen (La Jolla, California);  Mike Whitney (San Diego, California);  Dina Hingorani (San Diego, California);  Roger Y. Tsien (Eugene, Oregon);  Stephen Adams (Poway, California)
ABSTRACT The present invention provides methods for guiding preservation of human neurons or human nerves during surgery by administering a fluorescently-labeled peptide that specifically binds to the human neurons or human nerves. The invention further provides human neuron or nerve targeting molecules comprising fluorescently-labeled peptides that specifically bind to human neurons or human nerves and compositions thereof.
FILED Monday, February 03, 2020
APPL NO 16/780782
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0014 (20130101)
A61K 9/0019 (20130101)
A61K 41/0057 (20130101)
A61K 47/64 (20170801)
A61K 49/0056 (20130101)

Peptides
C07K 7/00 (20130101)
C07K 7/08 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021518 Selsted et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) Michael E. Selsted (Pasadena, California);  Dat Q. Tran (Alhambra, California);  Justin B. Schaal (Orange, California)
ASSIGNEE(S) The University of Southern California (Los Angeles, California)
INVENTOR(S) Michael E. Selsted (Pasadena, California);  Dat Q. Tran (Alhambra, California);  Justin B. Schaal (Orange, California)
ABSTRACT Novel peptide analogs of a θ-defensin have been developed that provide a biphasic effect in treating infection and/or sepsis. These analogs are active at concentrations below those needed to provide a bactericidal or bacteriostatic effect, and function by initially recruiting effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response characteristic of sepsis and septic shock. These novel θ-defensin analogs are protective at concentrations where naturally occurring θ-defensins have no apparent effect, and include a core set of structural and sequence features not found in native θ-defensin.
FILED Friday, June 26, 2020
APPL NO 16/914038
ART UNIT 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/00 (20180101)

Peptides
C07K 7/64 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021533 Crowe, Jr.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S) VANDERBILT UNIVERSITY (Nashville, Tennessee)
INVENTOR(S) James E. Crowe, Jr. (Nashville, Tennessee)
ABSTRACT The present disclosure is directed to antibodies binding to and neutralizing Zika virus and methods for use thereof.
FILED Wednesday, November 01, 2017
APPL NO 16/346709
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/42 (20130101)
A61K 2039/55 (20130101)
A61K 2039/505 (20130101)
A61K 2039/545 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 16/1081 (20130101) Original (OR) Class
C07K 2317/21 (20130101)
C07K 2317/24 (20130101)
C07K 2317/31 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)
C07K 2317/565 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56983 (20130101)
G01N 2333/18 (20130101)
G01N 2333/185 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021535 Seder et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland);  SANARIA INC (Rockville, Maryland)
ASSIGNEE(S) The United States of America as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland);  Sanaria Inc. (Rockville, Maryland)
INVENTOR(S) Robert Seder (Chevy Chase, Maryland);  Neville Kisalu (Bethesda, Maryland);  Azza Idris (Bethesda, Maryland);  Barbara Flynn (Bethesda, Maryland);  Stephen Hoffman (Rockville, Maryland)
ABSTRACT Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.
FILED Monday, February 12, 2018
APPL NO 16/485354
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Peptides
C07K 16/205 (20130101) Original (OR) Class
C07K 2317/21 (20130101)
C07K 2317/34 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021539 Goldberg et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
INVENTOR(S) Michael Solomon Goldberg (Brookline, Massachusetts);  Chun Gwon Park (Seoul, South Korea)
ABSTRACT Provided are drug delivery compositions and devices useful for the treatment and/or prevention of cancer and metastatic tumors. For example, a drug delivery device is provided that comprises a biodegradable scaffold carrying one or more anti-cancer therapeutic agents that activate the innate immune system (e.g., STING agonists) and/or the adaptive immune system (e.g., anti-PD-1 antibodies). The compositions and devices may include a cytokine (e.g., IL-15 superagonist). The drug delivery device can be implanted in the void volume of a resected tumor to prevent tumor regrowth and tumor metastasis. Also provided are methods of making the drug delivery compositions and devices as well as kits containing materials to provide the compositions and devices.
FILED Thursday, August 01, 2019
APPL NO 16/529189
ART UNIT 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101)
A61K 9/0019 (20130101)
A61K 9/0024 (20130101)
A61K 31/444 (20130101)
A61K 31/444 (20130101)
A61K 31/635 (20130101)
A61K 31/635 (20130101)
A61K 31/4745 (20130101)
A61K 31/4745 (20130101)
A61K 35/17 (20130101)
A61K 38/19 (20130101)
A61K 38/19 (20130101)
A61K 38/1793 (20130101)
A61K 38/2086 (20130101)
A61K 39/3955 (20130101)
A61K 39/39541 (20130101)
A61K 39/39541 (20130101)
A61K 45/06 (20130101)
A61K 47/36 (20130101)
A61K 2039/505 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/52 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/04 (20180101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 21/04 (20130101)

Peptides
C07K 16/30 (20130101)
C07K 16/2818 (20130101) Original (OR) Class
C07K 16/2878 (20130101)
C07K 16/2896 (20130101)
C07K 2317/75 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021545 Kwon et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Young Jik Kwon (Irvine, California);  Margaret Lugin (Irvine, California)
ABSTRACT The disclosure provides for a multimodal cancer therapy comprising chimeric viral/nonviral nanoparticles and anticancer agents and uses thereof to treat a subject with cancer or suspected of having a cancer.
FILED Wednesday, July 31, 2019
APPL NO 16/528305
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7105 (20130101)
A61K 45/06 (20130101)

Peptides
C07K 14/4746 (20130101)
C07K 14/4747 (20130101)
C07K 16/32 (20130101)
C07K 16/40 (20130101)
C07K 16/3007 (20130101) Original (OR) Class
C07K 16/3053 (20130101)
C07K 16/3092 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/52 (20130101)
C12N 15/113 (20130101)
C12N 15/1135 (20130101)
C12N 2310/14 (20130101)
C12N 2320/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021687 Karp et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S) The Brigham And Women's Hospital, Inc. (Boston, Massachusetts);  Massachusetts Institute Of Technology (Cambridge, Massachusetts)
INVENTOR(S) Jeffrey Michael Karp (Brookline, Massachusetts);  Robert Samuel Langer (Newton, Massachusetts);  Xiaolei Yin (Quincy, Massachusetts)
ABSTRACT A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate ChgA and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of ChgA is such that the fraction of cells expressing CGA in the obtained cell population, as measured by a ChgA Immunostaining Assay, is at least about 1.5%. Small molecules that can be used to differentiate the post-natal cells into the enteroendocrine cells can include at least one of a Wnt activator, a Notch inhibitor, a Wnt inhibitor, a MEK/ERK inhibitor, a growth factor, a HDAC inhibitor, a Histone Methylation Inhibitor, a Tgf-β inhibitor, and a NeuroD1 activator. Also, the insulin expression of a population of mammalian cells is increased by treating the population with a plurality of small molecules that increase the insulin expression.
FILED Friday, January 06, 2017
APPL NO 15/400877
ART UNIT 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0613 (20130101)
C12N 5/0678 (20130101) Original (OR) Class
C12N 5/0679 (20130101)
C12N 2500/38 (20130101)
C12N 2500/62 (20130101)
C12N 2501/01 (20130101)
C12N 2501/11 (20130101)
C12N 2501/13 (20130101)
C12N 2501/15 (20130101)
C12N 2501/42 (20130101)
C12N 2501/065 (20130101)
C12N 2501/71 (20130101)
C12N 2501/72 (20130101)
C12N 2501/119 (20130101)
C12N 2501/155 (20130101)
C12N 2501/335 (20130101)
C12N 2501/395 (20130101)
C12N 2501/415 (20130101)
C12N 2501/727 (20130101)
C12N 2501/999 (20130101)
C12N 2502/23 (20130101)
C12N 2533/90 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021688 Koehler et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Indianapolis, Indiana)
ASSIGNEE(S) INDIANA UNIVERSITY RESEARCH ANND TECHNOLOGY CORPORATION (Indianapolis, Indiana)
INVENTOR(S) Karl R. Koehler (Indianapolis, Indiana);  Jiyoon Lee (Indianapolis, Indiana)
ABSTRACT Provided herein are methods for directing differentiation of human pluripotent stem cells into a three-dimensional multilayered skin composition comprising an epidermal layer, a dermal layer, and a plurality of cells capable of forming a functional hair follicle. Also provided herein are three-dimensional, multilayered engineered skin compositions and methods of using the same for drug screening, for screening compounds for effects on hair growth, and for other applications.
FILED Friday, October 21, 2016
APPL NO 15/769139
ART UNIT 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/36 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/52 (20130101)
A61L 27/54 (20130101)
A61L 27/56 (20130101)
A61L 27/58 (20130101)
A61L 27/60 (20130101)
A61L 27/362 (20130101)
A61L 27/3633 (20130101)
A61L 27/3641 (20130101)
A61L 27/3687 (20130101)
A61L 27/3813 (20130101)
A61L 27/3834 (20130101)
A61L 27/3839 (20130101)
A61L 27/3891 (20130101)
A61L 27/3895 (20130101)
A61L 2300/64 (20130101)
A61L 2300/412 (20130101)
A61L 2300/604 (20130101)
A61L 2430/34 (20130101)
A61L 2430/40 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0627 (20130101)
C12N 5/0629 (20130101)
C12N 5/0656 (20130101)
C12N 5/0698 (20130101) Original (OR) Class
C12N 2501/15 (20130101)
C12N 2501/115 (20130101)
C12N 2501/155 (20130101)
C12N 2501/999 (20130101)
C12N 2502/092 (20130101)
C12N 2502/094 (20130101)
C12N 2502/1323 (20130101)
C12N 2506/02 (20130101)
C12N 2506/03 (20130101)
C12N 2506/45 (20130101)
C12N 2506/1346 (20130101)
C12N 2513/00 (20130101)
C12N 2533/76 (20130101)
C12N 2533/90 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6876 (20130101)
C12Q 2600/136 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021703 Jaffrey et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S) CORNELL UNIVERSITY (Ithaca, New York)
INVENTOR(S) Samie R. Jaffrey (New York, New York);  Kate D. Meyer (New York, New York);  Christopher E. Mason (New York, New York)
ABSTRACT This invention relates to a method of characterizing the modified base status of a transcriptome, which involves contacting a transcriptome comprising one or more modified bases with an antibody specific to the modified bases under conditions effective to bind the antibody to the modified bases; isolating, from the transcriptome, a pool of RNA transcripts to which the antibody binds; and identifying isolated RNA transcripts that are present in a higher abundance in the isolated pool relative to the transcriptome, where each of the isolated RNA transcripts that are present in a higher abundance in the isolated pool together characterize the modified base status of the transcriptome. Also disclosed are a method of diagnosis or prognosis of a disease, a method of determining the effect of a treatment on modified base levels in RNA, and a kit for characterizing the modified base status of a transcriptome.
FILED Monday, February 18, 2013
APPL NO 14/377680
ART UNIT 1699 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1093 (20130101) Original (OR) Class

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6804 (20130101)
C12Q 1/6804 (20130101)
C12Q 2545/114 (20130101)
C12Q 2563/149 (20130101)
C12Q 2565/113 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021706 Geller et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Oregon State University (Corvallis, Oregon);  Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S) Board of Regents, The University of Texas System (Austin, Texas);  Oregon State University (Corvallis, Oregon)
INVENTOR(S) Bruce L. Geller (Corvallis, Oregon);  David Greenberg (Coppell, Texas)
ABSTRACT Provided are antisense morpholino oligomers targeted against bacterial virulence factors such as genes that contribute to antibiotic resistance or biofilm formation, or genes associated with fatty acid biosynthesis, and related compositions and methods of using the oligomers and compositions, for instance, in the treatment of an infected mammalian subject.
FILED Friday, September 01, 2017
APPL NO 15/693796
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 47/64 (20170801)
A61K 47/6455 (20170801)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2310/3233 (20130101)
C12N 2310/3513 (20130101)
C12N 2320/50 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021709 Sliz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S) Piotr Sliz (Canton, Massachusetts);  Yunsun Nam (Dallas, Texas)
ABSTRACT The invention provides compositions and methods for regulating microRNA (miRNA) biogenesis. The invention also relates to compositions and methods for treating or preventing cancer in a subject in need thereof.
FILED Friday, May 29, 2020
APPL NO 16/887632
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/712 (20130101)
A61K 31/713 (20130101)
A61K 31/7105 (20130101)
A61K 31/7115 (20130101)
A61K 45/06 (20130101)
A61K 47/60 (20170801)
A61K 47/645 (20170801)
A61K 48/00 (20130101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 21/02 (20130101)

Peptides
C07K 14/47 (20130101)
C07K 14/4702 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1135 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2310/141 (20130101)
C12N 2310/531 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021712 Hou et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Jianghui Hou (St. Louis, Missouri);  Yong-feng Gong (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Jianghui Hou (St. Louis, Missouri);  Yong-feng Gong (St. Louis, Missouri)
ABSTRACT Among the various aspects of the present disclosure is the provision of miRNA mimics and uses thereof. An aspect of the present disclosure provides for compositions of miRNA mimic molecules and methods of treating metabolic disorders using miRNA mimic molecules.
FILED Thursday, September 05, 2019
APPL NO 16/561602
ART UNIT 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/10 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1138 (20130101) Original (OR) Class
C12N 2310/141 (20130101)
C12N 2310/321 (20130101)
C12N 2310/351 (20130101)
C12N 2310/3515 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021737 Church et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) George M. Church (Brookline, Massachusetts);  Je-hyuk Lee (Allston, Massachusetts);  Daniel Levner (Boston, Massachusetts);  Michael Super (Lexington, Massachusetts)
ABSTRACT Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
FILED Wednesday, July 29, 2020
APPL NO 16/941585
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 19/34 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101) Original (OR) Class
C12Q 1/6844 (20130101)
C12Q 1/6869 (20130101)
C12Q 1/6874 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021740 Abudayyeh et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts);  PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Omar Abudayyeh (Cambridge, Massachusetts);  James Joseph Collins (Newton, Massachusetts);  Jonathan Gootenberg (Cambridge, Massachusetts);  Feng Zhang (Cambridge, Massachusetts);  Eric S. Lander (Cambridge, Massachusetts)
ABSTRACT The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
FILED Thursday, March 15, 2018
APPL NO 15/922837
ART UNIT 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/5023 (20130101)
B01L 7/52 (20130101)
B01L 2300/0825 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 9/96 (20130101)
C12N 15/11 (20130101)
C12N 2310/20 (20170501)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/682 (20130101)
C12Q 1/6816 (20130101)
C12Q 1/6823 (20130101)
C12Q 1/6827 (20130101)
C12Q 1/6832 (20130101) Original (OR) Class
C12Q 1/6876 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/558 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021741 Wu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Chao-ting Wu (Brookline, Massachusetts);  Son Nguyen (West Roxbury, Massachusetts)
ABSTRACT The present invention relates to a method of covalently attaching a chromosome within a cell to a matrix including modifying a plurality of nucleotides within the chromosome to include a matrix attachment moiety wherein the chromosome contacts the matrix, and attaching the matrix attachment moiety of the plurality of nucleotides to the matrix, thereby attaching the chromosome to the matrix.
FILED Wednesday, April 19, 2017
APPL NO 16/095456
ART UNIT 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 19/34 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/68 (20130101)
C12Q 1/68 (20130101)
C12Q 1/6841 (20130101) Original (OR) Class
C12Q 2523/101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021750 Baird et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Research Foundation for State University of New York (Albany, New York)
ASSIGNEE(S) THE RESEARCH FOUNDATION FOR STATE UNIVERSITY OF NEWYORK (Albany, New York)
INVENTOR(S) Alison E. Baird (Brooklyn, New York);  Mateusz Adamski (Kradow, Poland)
ABSTRACT Biomarkers useful for the diagnosis and treatment of acute ischemic stroke are disclosed. Also provided is a quantitative assay method for accurately identifying transcript number in a biological sample.
FILED Tuesday, October 14, 2014
APPL NO 15/028732
ART UNIT 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101)
C12Q 1/6851 (20130101)
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022529 Zheng et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
United States Air Force (USAF)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
Department of Agriculture (USDA)
APPLICANT(S) The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S) The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S) Siyang Zheng (State College, Pennsylvania);  Mauricio Terrones (State College, Pennsylvania);  Yin-Ting Yeh (State College, Pennsylvania);  Yi Tang (State College, Pennsylvania);  Huaguang Lu (State College, Pennsylvania);  Nestor Perea Lopez (State College, Pennsylvania);  Yiqiu Xia (State College, Pennsylvania)
ABSTRACT The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.
FILED Friday, February 07, 2020
APPL NO 16/784507
ART UNIT 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502707 (20130101)
B01L 3/502715 (20130101)
B01L 3/502753 (20130101)
B01L 3/502761 (20130101)
B01L 2200/12 (20130101)
B01L 2200/0668 (20130101)
B01L 2300/12 (20130101)
B01L 2300/041 (20130101)
B01L 2300/0681 (20130101)
B01L 2300/0896 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/405 (20130101) Original (OR) Class
G01N 1/4077 (20130101)
G01N 33/552 (20130101)
G01N 33/54346 (20130101)
G01N 33/56983 (20130101)
G01N 2001/4088 (20130101)
G01N 2333/11 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022601 Ezzelarab et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) University of Pittsburgh Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)  (Pittsburgh, Pennsylvania)
INVENTOR(S) Mohamed B. Ezzelarab (Pittsburgh, Pennsylvania);  Angus W. Thomson (Pittsburgh, Pennsylvania)
ABSTRACT Pre-existing alloreactive memory T cells are a major barrier to the induction of allograft tolerance in organ transplant recipients. The use of Eomesodermin (Eomes) expression in memory T cells to determine the risk of allograft rejection in a subject is described. Also described is the use of Eomes expression in memory T cells of transplant recipients to modify immunosuppressive therapy.
FILED Friday, January 22, 2016
APPL NO 15/545414
ART UNIT 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5005 (20130101) Original (OR) Class
G01N 2333/4703 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022602 Carlson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
ASSIGNEE(S) REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
INVENTOR(S) Erin Elizabeth Carlson (Minneapolis, Minnesota);  Shabnam Sharifzadeh (Minneapolis, Minnesota)
ABSTRACT The invention provides a conjugate of formula I:
R-L-Y   I
or a salt thereof, wherein R, L, and Y have any of the values described in the specification, as well as compositions comprising a conjugate of formula I. The conjugates are useful for labeling.
FILED Friday, April 06, 2018
APPL NO 15/947302
ART UNIT 1624 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/397 (20130101)
A61K 47/12 (20130101)
A61K 47/16 (20130101)
A61K 47/22 (20130101)
A61K 47/552 (20170801)
A61K 49/0021 (20130101)
A61K 49/0041 (20130101)
A61K 49/0052 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Heterocyclic Compounds
C07D 477/00 (20130101)
C07D 501/20 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/58 (20130101)
G01N 33/532 (20130101)
G01N 33/566 (20130101)
G01N 33/5008 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022605 Hickman et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) University of Central Florida Research Foundation, Inc. (Orlando, Florida)
ASSIGNEE(S) University of Central Florida Research Foundation, Inc. (Orlando, Florida)
INVENTOR(S) James Hickman (Orlando, Florida);  Lee Kumanchik (Orlando, Florida);  Navaneetha Santhanam (Orlando, Florida)
ABSTRACT Disclosed herein are cell culture analog devices, systems and methods for applying stimuli to components containing different cell types and recording the cell responses before, during, and after a stimulus (for example, a drug, metabolite, toxin, or electrical stimulus) is introduced. Responses can be stored to a database and compared to previous results. By analyzing how each cell type responds to various stimulation parameters, for example, by using multivariate analyses, cell signaling pathway information can be determined or new pathways can be discovered. In some implementations, an individual component interfaces with a specific cell type. This facilitates readout of the cell response to the stimulation. Various components can also interface with each other, such that the behavior of one cell type can affect a cell type in another component. Once assembled, the system is plugged into readout electronics and a programmable electrical stimulator.
FILED Wednesday, August 16, 2017
APPL NO 16/328417
ART UNIT 1799 — Organic Chemistry
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 23/12 (20130101)
C12M 41/46 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/502 (20130101)
G01N 33/5014 (20130101) Original (OR) Class
G01N 33/5029 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022613 Zhang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S) The Johns Hopkins University (Baltimore, Maryland)
INVENTOR(S) Hui Zhang (Ellicott City, Maryland);  Xingde Li (Ellicott City, Maryland);  Shadi Toghi Eshghi (Baltimore, Maryland)
ABSTRACT The presently disclosed subject matter provides methods using mass spectrometry for direct profiling of N-linked glycans from a biological sample. In addition, the embodiments of the present invention also disclose novel methods, known as targeted analyte detection (TAD), for improving the detection limit of MALDI-MS. These methods take advantage of the carrier effect of the added standard analytes, which occurs due to the generic sigmoidal shape of the calibration curve. The functionality of TAD depends on the relative enhancement of sensitivity over the increase of the standard deviation at the analysis of target analytes with spiking in exogenous concentration. At certain ranges of exogenous concentration, the increment in the sensitivity overcomes the standard deviation, resulting in an improved LOD. Theoretically, exogenous concentrations approximately at 1 LODorig would generate the optimum LOD improvement. TAD is a cost-effective LOD improvement method, which is not limited to a certain group of analytes, or detection methods or instruments. It can be applied to enhance the detection of any analyte with different detection methods, provided that the analyte of interest can be extracted or is available in synthetic form.
FILED Thursday, August 15, 2019
APPL NO 16/541581
ART UNIT 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6842 (20130101) Original (OR) Class
G01N 33/6851 (20130101)
G01N 2400/12 (20130101)
G01N 2570/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022615 Brusko et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida)
ASSIGNEE(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida)
INVENTOR(S) Todd M. Brusko (Gainesville, Florida);  Christopher Fuhrman (Cambridge, Massachusetts);  Howard R. Seay (Gainesville, Florida)
ABSTRACT The invention pertains to methods of isolating a Treg from a subject, the method comprising the steps of analyzing a sample of cells obtained from the subject to determine the level of expression of polypeptides and/or polynucleotides corresponding to proteins CD 127, CD4, CD25, and CD226 and isolating, as the Treg, a cell which expresses CD4 and CD25, expresses low levels of CD 127 or does not express CD 127, and expresses low levels of CD226 or does not express CD226. The Treg isolated from a subject can be proliferated in vitro. Accordingly, the invention also provides compositions comprising Treg isolated/proliferated according to the methods of the invention and pharmaceutically acceptable carrier and/or excipient. The pharmaceutical compositions can be used to treat and/or prevent inflammation mediated disease, for example, autoimmune diseases, such as, systemic lupus erythmatosus, rheumatoid arthritis, Multiple Sclerosis, type 1 diabetes, or inflammatory bowel disease.
FILED Wednesday, May 04, 2016
APPL NO 15/571823
ART UNIT 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0637 (20130101)
C12N 2501/2312 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1459 (20130101)
G01N 33/6854 (20130101) Original (OR) Class
G01N 2015/149 (20130101)
G01N 2333/70503 (20130101)
G01N 2333/70514 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022618 Sierks et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
INVENTOR(S) Michael Sierks (Ft. McDowell, Arizona);  Stephanie Williams (Phoenix, Arizona);  Lalitha Venkataraman (Tempe, Arizona)
ABSTRACT The invention relates to antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with frontotemporal dementia (FTD), but not TDP-43 associated with amyotrophic lateral sclerosis (ALS) or TDP-43 associated with healthy human brain tissue, and antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with ALS, but not TDP-43 associated FTD or TDP-43 associated with healthy human brain tissue.
FILED Wednesday, December 05, 2018
APPL NO 16/211006
ART UNIT 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Peptides
C07K 16/18 (20130101)
C07K 2317/622 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6896 (20130101) Original (OR) Class
G01N 2800/285 (20130101)
G01N 2800/2814 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022665 Setsompop et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S) The General Hospital Corporation (Boston, Massachusetts)
INVENTOR(S) Kawin Setsompop (Charlestown, Massachusetts);  Lawrence L. Wald (Cambridge, Massachusetts);  Fuyixue Wang (Cambridge, Massachusetts)
ABSTRACT Systems and methods for magnetic resonance imaging (“MRI”) that address the geometric distortions and blurring common to conventional echo planar imaging (“EPI”) sequences, and that provide new temporal signal evolution information across the EPI readout, are described. Echo planar time-resolved imaging (“EPTI”) schemes are described to implement an accelerated sampling of a hybrid space spanned by the phase encoding dimension and the temporal dimension. In general, each EPTI shot covers a segment of this hybrid space using a zigzag trajectory with an interleaved acceleration in the phase-encoding direction. The hybrid space may be undersampled and a tilted reconstruction kernel used to synthesize additional data samples.
FILED Monday, June 03, 2019
APPL NO 16/430349
ART UNIT 2852 — Printing/Measuring and Testing
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/482 (20130101) Original (OR) Class
G01R 33/5602 (20130101)
G01R 33/5616 (20130101)
G01R 33/56563 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023820 Fang
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S) UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts)
INVENTOR(S) Hua Fang (Shrewsbury, Massachusetts)
ABSTRACT A multiple imputation (MI) based fuzzy clustering with visualization-aided MI validation that improves the accuracy and the stability of identified patterns, generally the structure of HD data with missing values.
FILED Friday, February 06, 2015
APPL NO 15/116570
ART UNIT 2126 — AI & Simulation/Modeling
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6202 (20130101)
G06K 9/6218 (20130101)
G06K 9/6253 (20130101)

Computer Systems Based on Specific Computational Models
G06N 7/02 (20130101) Original (OR) Class

Image Data Processing or Generation, in General
G06T 7/20 (20130101)
G06T 2207/30241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024018 Sarkar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The United States of America as represented by the Secretary of the Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Susanta Kumar Sarkar (Rockville, Maryland);  Ambika Bumb (Greer, South Carolina);  Keir Cajal Neuman (Bethesda, Maryland)
ABSTRACT One aspect of the invention provides an imaging method including: (a) acquiring a first fluorescent image of an object of interest impregnated with fluorescent nanodiamonds; (b) applying a magnetic field to the fluorescent nanodiamonds in order to decrease fluorescence of the fluorescent nanodiamonds; (c) acquiring a second fluorescent linage of the object of interest; and (d) subtracting the second fluorescent linage from the first fluorescent image to produce a resulting image. Another aspect of the invention provides an imaging method including: (a) applying a time-varying magnetic field to an object of interest impregnated with fluorescent nanodiamonds to modulate the fluorescence of the fluorescent nanodiamonds; (b) acquiring a plurality of fluorescent images of the object of interest; and (c) for each corresponding pixel in the plurality of fluorescent images, calculating a fluorescence intensity using a lock-in technique.
FILED Monday, August 22, 2016
APPL NO 15/243765
ART UNIT 2667 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6428 (20130101)
G01N 21/6458 (20130101)
G01N 21/6486 (20130101)
G01N 2021/6439 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00134 (20130101)

Image Data Processing or Generation, in General
G06T 5/003 (20130101)
G06T 5/50 (20130101) Original (OR) Class
G06T 7/0012 (20130101)
G06T 2207/10016 (20130101)
G06T 2207/10056 (20130101)
G06T 2207/10064 (20130101)
G06T 2207/20182 (20130101)
G06T 2207/20216 (20130101)
G06T 2207/20224 (20130101)
G06T 2207/30024 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024024 Arnold et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Corey Arnold (Oakland, California);  King Chung Ho (Oakland, California);  Fabien Scalzo (Oakland, California)
ABSTRACT Systems and methods for analyzing perfusion-weighted medical imaging using deep neural networks are provided. In some aspects, a method includes receiving perfusion-weighted imaging data acquired from a subject using a magnetic resonance (“MR”) imaging system and modeling at least one voxel associated with the perfusion-weighted imaging data using a four-dimensional (“4D”) convolutional neural network. The method also includes extracting spatio-temporal features for each modeled voxel and estimating at least one perfusion parameter for each modeled voxel based on the extracted spatio-temporal features. The method further includes generating a report using the at least one perfusion parameter indicating perfusion in the subject.
FILED Thursday, December 15, 2016
APPL NO 16/062159
ART UNIT 2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0263 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 2209/05 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/049 (20130101)
G06N 5/046 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101) Original (OR) Class
G06T 2200/04 (20130101)
G06T 2207/10096 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30016 (20130101)
G06T 2207/30096 (20130101)
G06T 2207/30104 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024025 Meyer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) University of Virginia Patent Foundation (Charlottesville, Virginia)
ASSIGNEE(S) University of Virginia Patent Foundation (Charlottesville, Virginia)
INVENTOR(S) Craig H. Meyer (Charlottesville, Virginia);  Anudeep Konda (Los Angeles, California);  Christopher M. Kramer (Charlottesville, Virginia);  Xue Feng (Charlottesville, Virginia)
ABSTRACT In one aspect the disclosed technology relates to embodiments of a method which, includes acquiring magnetic resonance imaging data, for a plurality of images, of the heart of a subject. The method also includes segmenting, using cascaded convolutional neural networks (CNN), respective portions of the images corresponding to respective epicardium layers and endocardium layers for a left ventricle (LV) and a right ventricle (RV) of the heart. The segmenting is used for extracting biomarker data from segmented portions of the images and, in one embodiment, assessing hypertrophic cardiomyopathy from the biomarker data. The method further includes segmenting processes for T1 MRI data and LGE MRI data.
FILED Thursday, March 07, 2019
APPL NO 16/295939
ART UNIT 2668 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/029 (20130101)
A61B 5/0263 (20130101)
A61B 5/1071 (20130101)
A61B 5/1075 (20130101)
A61B 5/7267 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6228 (20130101)
G06K 2209/051 (20130101)

Image Data Processing or Generation, in General
G06T 7/11 (20170101)
G06T 7/0012 (20130101) Original (OR) Class
G06T 7/13 (20170101)
G06T 7/62 (20170101)
G06T 7/70 (20170101)
G06T 2207/10088 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30048 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024096 Leuze et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) Christoph Leuze (Palo Alto, California);  Supriya Sathyanarayana (Milpitas, California);  Jennifer McNab (Stanford, California)
ABSTRACT 3D alignment of a virtual model and corresponding real-world object is provided. A user places virtual tags on the real-world object as viewed through an augmented reality device. By placing these tags at the positions where he perceives certain real-world landmark locations, this allows for correction of misalignments between virtual content on the AR display and the real world. In particular, the virtual model include virtual landmarks that correspond to the real-world landmarks. Thus aligning the virtual landmarks of the virtual model to the virtual tags provides accurate alignment of the virtual model to the corresponding real-world object.
FILED Wednesday, April 29, 2020
APPL NO 16/861220
ART UNIT 2613 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 7/344 (20170101)
G06T 19/006 (20130101) Original (OR) Class
G06T 2207/30201 (20130101)
G06T 2207/30204 (20130101)
G06T 2215/16 (20130101)
G06T 2219/004 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024429 Patek et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Science Foundation (NSF)
APPLICANT(S) Stephen D. Patek (Charlottesville, Virginia);  Boris P. Kovatchev (Charlottesville, Virginia)
ASSIGNEE(S) UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia)
INVENTOR(S) Stephen D. Patek (Charlottesville, Virginia);  Boris P. Kovatchev (Charlottesville, Virginia)
ABSTRACT An Adaptive Advisory Control (AA Control) interactive process involving algorithm-based assessment and communication of physiologic and behavioral parameters and patterns assists patients with diabetes with the optimization of their glycemic control. The method and system may uses all available sources of information about the patient; (i) EO Data (e.g. self-monitoring of blood glucose (SMBG) and CMG), (ii) Insulin Data (e.g. insulin pump log files or patient treatment records), and (iii) Patient Self Reporting Data (e.g. self treatment behaviors, meals, and exercise) to: retroactively assess the risk of hypoglycemia, retroactively assess risk-based reduction of insulin delivery, and then report to the patient how a risk-based insulin reduction system would have acted consistently to prevent hypoglycemia.
FILED Sunday, August 26, 2012
APPL NO 14/241383
ART UNIT 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/002 (20130101)
A61B 5/0022 (20130101)
A61B 5/486 (20130101)
A61B 5/743 (20130101)
A61B 5/1118 (20130101)
A61B 5/4812 (20130101)
A61B 5/4839 (20130101)
A61B 5/4848 (20130101)
A61B 5/4857 (20130101)
A61B 5/4866 (20130101)
A61B 5/7225 (20130101)
A61B 5/7275 (20130101)
A61B 5/7278 (20130101)
A61B 5/7282 (20130101)
A61B 5/7475 (20130101)
A61B 5/14532 (20130101)
A61B 2505/07 (20130101)
A61B 2560/0295 (20130101)
A61B 2560/0475 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/1723 (20130101)
A61M 5/16886 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/17 (20180101)
G16H 20/30 (20180101)
G16H 50/30 (20180101)
G16H 50/50 (20180101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11025574 Hsu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Office of the Director (NIHOD)
APPLICANT(S) Salk Institute for Biological Studies (La Jolla, California)
ASSIGNEE(S) Salk Institute for Biological Studies (La Jolla, California)
INVENTOR(S) Patrick D. Hsu (San Diego, California);  Silvana Konermann (Menlo Park, California)
ABSTRACT Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
FILED Wednesday, June 03, 2020
APPL NO 16/891574
ART UNIT 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/85 (20130101)
C12N 15/102 (20130101)
C12N 15/113 (20130101)
C12N 15/8201 (20130101)
C12N 15/8213 (20130101)
C12N 2310/16 (20130101)
C12N 2310/20 (20170501)
C12N 2310/3519 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/08 (20130101)
H04L 9/30 (20130101)
H04L 45/745 (20130101)
H04L 51/08 (20130101)
H04L 51/12 (20130101) Original (OR) Class
H04L 51/14 (20130101)
H04L 51/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 11020279 Barofsky
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) RevMedx, Inc. (Wilsonville, Oregon)
ASSIGNEE(S) RevMedx, Inc. (Wilsonville, Oregon)
INVENTOR(S) Andrew Barofsky (Lake Oswego, Oregon)
ABSTRACT Embodiments herein provide hemostatic compositions comprising a plurality of liquid-expandable articles arranged on a backing material. In general, embodiments include methods for treating hemorrhagic injuries. More specifically, there is provided a method to effect rapid hemostatic response and control hemorrhage by introducing a hemostatic composition into a bleeding wound cavity. An embodiment also provides a method of preparing or manufacturing such a hemostatic composition.
FILED Friday, October 27, 2017
APPL NO 15/796663
ART UNIT 1699 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 13/00051 (20130101)
A61F 13/0233 (20130101)
A61F 13/0243 (20130101) Original (OR) Class
A61F 2013/00463 (20130101)
A61F 2013/00468 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020352 Myerson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Space and Naval Warfare Systems (SPAWAR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Allan S. Myerson (Cambridge, Massachusetts);  Mohammad A. Azad (Greensboro, North Carolina);  Gregory J. Hammersmith (Windsor, Connecticut);  David Brancazio (Cambridge, Massachusetts);  Juan Guillermo Osorio Caicedo (Elizabeth, New Jersey)
ABSTRACT Systems and methods for fabricating ingestible pharmaceutical tablets are provided. Certain of the systems and methods described herein are capable of manufacturing tablets of different dosages without the need to fluidically connect or disconnect unit operations when switching from a tablet having a first dosage to a tablet having a second, different dosage. Certain of the systems and methods described herein are capable of manufacturing compositionally tablets, e.g., tablets with different active pharmaceutical ingredients (APIs).
FILED Tuesday, May 26, 2020
APPL NO 16/883909
ART UNIT 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding
CURRENT CPC
Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle
A61J 3/10 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 9/2009 (20130101)
A61K 9/2013 (20130101)
A61K 9/2018 (20130101)
A61K 9/2095 (20130101) Original (OR) Class
A61K 31/192 (20130101)
A61K 31/5513 (20130101)

Mixing, e.g Dissolving, Emulsifying, Dispersing
B01F 13/1061 (20130101)
B01F 13/1063 (20130101)

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 43/34 (20130101)

Presses in General
B30B 11/08 (20130101)
B30B 11/027 (20130101)
B30B 15/302 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020404 Haudenschild et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) The Regents Of The University Of California, Davis (Oakland, California)
INVENTOR(S) Dominik Haudenschild (Davis, California);  Jasper Yik (Elk Grove, California)
ABSTRACT Provided are methods for the combined use of cyclin-dependent kinase 9 (CDK9) inhibitors and bromodomain containing 4 (BRD4) inhibitors to reduce, inhibit and/or prevent cartilage degradation and systemic traumatic inflammation. A combination of CDK9 inhibitors and BRD4 inhibitors can be used to reduce, inhibit and/or prevent cartilage degradation and loss of cartilage viability during allograft storage. A combination of CDK9 inhibitors and BRD4 inhibitors can be used as a post-injury intervention treatment to reduce, inhibit and/or prevent the acute cellular responses that lead to future cartilage degradation and osteoarthritis.
FILED Thursday, May 23, 2019
APPL NO 16/421218
ART UNIT 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/00 (20130101)
A61K 31/352 (20130101)
A61K 31/352 (20130101)
A61K 31/445 (20130101)
A61K 31/551 (20130101)
A61K 31/551 (20130101)
A61K 31/5513 (20130101) Original (OR) Class
A61K 31/5513 (20130101)
A61K 45/06 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)
A61K 2300/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020509 Francis et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Embody, Inc. (Norfolk, Virginia)
ASSIGNEE(S) Embody, Inc. (Norfolk, Virginia)
INVENTOR(S) Michael P. Francis (Norfolk, Virginia);  Stella Petrova (Blacksburg, Virginia);  Nicholas Thayer (Morrisville, North Carolina)
ABSTRACT A biopolymer fiber containing collagen. The biopolymer fiber has excellent ultimate tensile strength, modulus of elasticity, and strain at break comparable to native human tendons and ligaments. The fiber may substantially circular, ovoid, square, rectangular, ribbon-like, triangular, or irregularly shaped. The fiber exhibits an ordered, longitudinally-oriented structure, and the fiber allows infiltration of cellular growth. Implantable biopolymer scaffolds and sutures containing the fibers are provided as well as microfluidic and extrusion methods for producing the biopolymer fibers.
FILED Friday, January 31, 2020
APPL NO 16/779196
ART UNIT 1615 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 17/14 (20130101)
A61L 17/105 (20130101)
A61L 27/24 (20130101) Original (OR) Class
A61L 27/386 (20130101)
A61L 27/3804 (20130101)
A61L 2430/10 (20130101)

Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons
D01D 5/02 (20130101)
D01D 5/06 (20130101)
D01D 5/38 (20130101)
D01D 7/00 (20130101)

Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments
D01F 4/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020521 Golobish et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
APPLICANT(S) CytoSorbents Corporation (Monmouth Junction, New Jersey)
ASSIGNEE(S) CYTOSORBENTS CORPORATION (Monmouth Junction, New Jersey)
INVENTOR(S) Thomas D. Golobish (Princeton, New Jersey);  Vincent J. Capponi (Lawrenceville, New Jersey);  David R. Clay (West Orange, New Jersey)
ABSTRACT The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body.
FILED Friday, April 17, 2020
APPL NO 16/851305
ART UNIT 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 1/02 (20130101)
A01N 1/0215 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 1/34 (20130101)
A61M 1/36 (20130101)
A61M 1/0272 (20130101)
A61M 1/3679 (20130101) Original (OR) Class

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/261 (20130101)
B01J 20/267 (20130101)
B01J 20/3208 (20130101)
B01J 20/3246 (20130101)
B01J 20/3248 (20130101)
B01J 20/3251 (20130101)
B01J 20/3272 (20130101)
B01J 20/3282 (20130101)
B01J 20/3285 (20130101)
B01J 20/28069 (20130101)
B01J 20/28078 (20130101)
B01J 20/28092 (20130101)
B01J 2220/62 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020590 Pakhomov et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) Old Dominion University Research Foundation (Norfolk, Virginia)
ASSIGNEE(S) OLD DOMINION UNIVERSITY RESEARCH FOUNDATION (Norfolk, Virginia)
INVENTOR(S) Andrei G. Pakhomov (Norfolk, Virginia);  Olga N. Pakhomova (Norfolk, Virginia);  Shu Xiao (Norfolk, Virginia)
ABSTRACT Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
FILED Thursday, August 16, 2018
APPL NO 16/104089
ART UNIT 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/36 (20130101)
A61N 1/323 (20130101) Original (OR) Class
A61N 1/327 (20130101)
A61N 1/0412 (20130101)
A61N 1/0476 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 13/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020617 Konofagou et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Elisa E. Konofagou (New York, New York);  Matthew Downs (New York, New York);  Stephen Lee (New York, New York);  Min Gon Kim (Fort Lee, New Jersey);  Hermes Arytto Salles Kamimura (New York, New York)
ABSTRACT Techniques for modulating peripheral nerves using focused ultrasound (FUS) are provided. Methods include locating a peripheral nerve in a subject using an imaging probe, providing a FUS having one or more ultrasound parameters to a location on the peripheral nerve, and modulating the peripheral nerve. The methods can further include eliciting and measuring a physiological response from the FUS modulation, generating tissue deformation in the vicinity of the FUS modulation, and imaging the nerve and the tissue deformation simultaneously with FUS modulation. Systems for use in the modulation of peripheral nerves are also provided.
FILED Friday, February 01, 2019
APPL NO 16/265827
ART UNIT 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/01 (20130101)
A61B 5/024 (20130101)
A61B 5/369 (20210101)
A61B 5/389 (20210101)
A61B 5/4836 (20130101)
A61B 8/14 (20130101)
A61B 8/42 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 7/00 (20130101) Original (OR) Class
A61N 7/02 (20130101)
A61N 2007/0026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020736 Abate et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Adam R. Abate (San Francisco, California);  Adam R. Sciambi (San Francisco, California);  Russell Cole (San Francisco, California);  Zev Jordan Gartner (Pacifica, California)
ABSTRACT Methods for delivering discrete entities including, e.g., cells, media or reagents to substrates are provided. In certain aspects, the methods include manipulating and/or analyzing qualities of the entities or biological components thereof. In some embodiments, the methods may be used to create arrays of microenvironments and/or for two and three-dimensional printing of tissues or structures. Systems and devices for practicing the subject methods are also provided.
FILED Tuesday, August 27, 2019
APPL NO 16/552982
ART UNIT 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/0268 (20130101) Original (OR) Class
B01L 3/502784 (20130101)
B01L 2200/0673 (20130101)
B01L 2300/0645 (20130101)
B01L 2300/0829 (20130101)
B01L 2300/0864 (20130101)
B01L 2400/086 (20130101)
B01L 2400/0427 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1459 (20130101)
G01N 15/1463 (20130101)
G01N 15/1484 (20130101)
G01N 2015/149 (20130101)
G01N 2015/1006 (20130101)
G01N 2035/1034 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021497 Chaput et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) John Chaput (Irvine, California);  Jen-Yu Liao (Irvine, California);  Saikat Bala (Irvine, California)
ABSTRACT The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.
FILED Thursday, April 04, 2019
APPL NO 16/374795
ART UNIT 1623 — Organic Chemistry
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/711 (20130101)

Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 27/138 (20130101)

Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 9/091 (20130101) Original (OR) Class

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 21/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021516 Ulijn et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
U.S. Air Force
Department of Energy (DOE)
UChicago Argonne, LLC (UCHICAGO)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
Division of Materials Research (DMR)
APPLICANT(S) Research Foundation of the City University of New York (New York, New York);  University of Strathclyde (Glasgow, United Kingdom);  Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S) Research Foundation of the City University of New York (New York, New York);  University of Strathclyde (Glasgow, United Kingdom);  Carnegie Mellon University (Pittsburgh, Pennsylvania)
INVENTOR(S) Rein V. Ulijn (New York, New York);  Ayala Lampel (Bronx, New York);  Tell Tuttle (Glasgow, United Kingdom);  Gary Scott (Glasgow, United Kingdom);  Scott McPhee (New York, New York);  Christopher Bettinger (Pittsburgh, Pennsylvania)
ABSTRACT A self-assembling peptide is provided that is enzymatically oxidized to form a polymeric pigment. The monomeric peptide has three amino acids (tyrosine (Y), one phenylalanine (F), and one aspartic acid (D) or one lysine (K)) and, following self-assembly and treatment with a tyrosinase enzyme oxidizes and polymerizes into a material with predetermined properties.
FILED Monday, September 11, 2017
APPL NO 16/332231
ART UNIT 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)

Peptides
C07K 5/0812 (20130101) Original (OR) Class
C07K 5/0819 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 69/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021521 Zgurskaya et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
APPLICANT(S) The Board of Regents of the University of Oklahoma (Norman, Oklahoma)
ASSIGNEE(S) THE BOARD OR REGENTS OF THE UNIVERSITY OF OKLAHOMA (Norman, Oklahoma)
INVENTOR(S) Helen Zgurskaya (Norman, Oklahoma);  Jon W. Weeks (Laurel, Maryland)
ABSTRACT Mutants of Gram-negative bacteria having outer membranes comprising modified OrbA nanopores absent an N-terminal plug domain are disclosed. The modified OrbA nanopores confer the outer membrane of the bacteria with enhanced permeability. The mutants of Gram-negative bacteria optionally comprise efflux-deficient efflux pumps. The mutants may be used, for example, in a screening method for identifying a compound having an anti-bacterial activity.
FILED Tuesday, September 18, 2018
APPL NO 16/134696
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Peptides
C07K 14/21 (20130101) Original (OR) Class
C07K 14/195 (20130101)
C07K 14/212 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021524 O'Malley et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Michelle O'Malley (Santa Barbara, California);  Kevin Solomon (Lafayette, Indiana);  Charles Haitjema (San Jose, California)
ABSTRACT Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.
FILED Wednesday, June 10, 2020
APPL NO 16/898421
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Peptides
C07K 14/37 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/00 (20130101)
C12N 9/0006 (20130101)
C12N 9/24 (20130101)
C12N 15/52 (20130101)
C12N 15/70 (20130101)
C12N 15/81 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/10 (20130101)
C12P 21/02 (20130101)
C12P 39/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021529 Bhatia et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Sangeeta N. Bhatia (Lexington, Massachusetts);  Ester Jihae Kwon (Cambridge, Massachusetts);  Leslie W. Chan (Boston, Massachusetts)
ABSTRACT Disclosed herein are antimicrobial constructs comprising a membrane interacting peptide and an antimicrobial agent. Also disclosed are methods for making and using the constructs.
FILED Thursday, March 01, 2018
APPL NO 15/909006
ART UNIT 1658 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/64 (20170801)
A61K 47/644 (20170801)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)

Peptides
C07K 7/06 (20130101)
C07K 14/79 (20130101) Original (OR) Class
C07K 14/4723 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021661 Strohm et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
APPLICANT(S) James J. Strohm (West Richland, Washington);  John C. Linehan (Richland, Washington);  Benjamin Q. Roberts (Richland, Washington);  Douglas L. McMakin (Richland, Washington);  David M. Sheen (Richland, Washington);  Jeffrey W. Griffin (Kennewick, Washington);  James A. Franz (Kennewick, Washington);  Charlene Franz (Kennewick, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) James J. Strohm (West Richland, Washington);  John C. Linehan (Richland, Washington);  Benjamin Q. Roberts (Richland, Washington);  Douglas L. McMakin (Richland, Washington);  David M. Sheen (Richland, Washington);  Jeffrey W. Griffin (Kennewick, Washington);  James A. Franz (Kennewick, Washington)
ABSTRACT Conversion of heavy fossil hydrocarbons (HFH) to a variety of value-added chemicals and/or fuels can be enhanced using microwave (MW) and/or radio-frequency (RF) energy. Variations of reactants, process parameters, and reactor design can significantly influence the relative distribution of chemicals and fuels generated as the product. In one example, a system for flash microwave conversion of HFH includes a source concentrating microwave or RF energy in a reaction zone having a pressure greater than 0.9 atm, a continuous feed having HFH and a process gas passing through the reaction zone, a HFH-to-liquids catalyst contacting the HFH in at least the reaction zone, and dielectric discharges within the reaction zone. The HFH and the catalyst have a residence time in the reaction zone of less than 30 seconds. In some instances, a plasma can form in or near the reaction zone.
FILED Tuesday, February 21, 2012
APPL NO 13/401216
ART UNIT 1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/088 (20130101)
B01J 19/0093 (20130101)
B01J 19/126 (20130101)
B01J 2219/0086 (20130101)
B01J 2219/00792 (20130101)
B01J 2219/00822 (20130101)
B01J 2219/00826 (20130101)
B01J 2219/00835 (20130101)
B01J 2219/0894 (20130101)
B01J 2219/00941 (20130101)
B01J 2219/1215 (20130101)
B01J 2219/1227 (20130101)
B01J 2219/1239 (20130101)
B01J 2219/1245 (20130101)
B01J 2219/1269 (20130101)
B01J 2219/1272 (20130101)

Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes
C10G 1/00 (20130101)
C10G 1/02 (20130101)
C10G 1/08 (20130101)
C10G 9/24 (20130101)
C10G 15/08 (20130101)
C10G 32/02 (20130101) Original (OR) Class

Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams
H05H 1/46 (20130101)
H05H 2001/4622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021730 Petillo et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Design-Zyme LLC (Lawrence, Kansas)
ASSIGNEE(S)
INVENTOR(S) Peter Albert Petillo (Lawrence, Kansas);  Dwight O'Dell Deay, III (Lawrence, Kansas);  Michael Gregory Branden (Lawrence, Kansas)
ABSTRACT The present invention is broadly concerned with new in vitro glycosylation methods that provide rational approaches for producing glycosylated proteins, and the use of glycosylated proteins. In more detail, the present invention comprises methods of glycosylating a starting protein having an amino sidechain with a nucleophilic moiety, comprising the step of reacting the protein with a carbohydrate having an oxazoline moiety on the reducing end thereof, to covalently bond the amino sidechain of the starting protein with the oxazoline moiety, wherein the glycosylated protein substantially retains the structure and function of the starting protein. Target proteins include oxidase, oxidoreductase and dehydrogenase enzymes. The glycosylated proteins advantageously have molecular weights of at least about 7500 Daltons. In a further embodiment, the present invention concerns the use of glycosylated proteins, fabricated by the methods disclosed herein, in the assembly of amperometric biosensors.
FILED Wednesday, December 19, 2018
APPL NO 16/224795
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Peptides
C07K 1/006 (20130101)
C07K 1/1077 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0004 (20130101)
C12N 9/0006 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 21/005 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/005 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021740 Abudayyeh et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts);  PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Omar Abudayyeh (Cambridge, Massachusetts);  James Joseph Collins (Newton, Massachusetts);  Jonathan Gootenberg (Cambridge, Massachusetts);  Feng Zhang (Cambridge, Massachusetts);  Eric S. Lander (Cambridge, Massachusetts)
ABSTRACT The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
FILED Thursday, March 15, 2018
APPL NO 15/922837
ART UNIT 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/5023 (20130101)
B01L 7/52 (20130101)
B01L 2300/0825 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 9/96 (20130101)
C12N 15/11 (20130101)
C12N 2310/20 (20170501)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/682 (20130101)
C12Q 1/6816 (20130101)
C12Q 1/6823 (20130101)
C12Q 1/6827 (20130101)
C12Q 1/6832 (20130101) Original (OR) Class
C12Q 1/6876 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/558 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021958 Juh et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
APPLICANT(S) United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S) RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S) Christopher M. Juh (Hobe Sound, Florida);  Scott D. Virkler (Ellington, Connecticut)
ABSTRACT A power turbine rotor assembly including a rotor shaft. The assembly also includes a rotor stack surrounding the rotor shaft. The assembly further includes a nut axially retaining the rotor stack. The assembly yet further includes a Vernier ring engaged with the nut and the rotor shaft, the Vernier ring having an inner ring, a plurality of inner tabs extending radially inward from the inner ring, and a plurality of outer tabs extending radially outward from the inner ring, the Vernier ring formed of at least two ring segments.
FILED Wednesday, October 31, 2018
APPL NO 16/176894
ART UNIT 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/025 (20130101) Original (OR) Class
F01D 5/026 (20130101)
F01D 5/066 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021967 Gallier et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S) General Electric Company (Schenectady, New York)
INVENTOR(S) Kirk D. Gallier (Cincinnati, Ohio);  Cedric Carlton Lowe (Cincinnati, Ohio)
ABSTRACT An apparatus and method of forming an engine component having an outer wall forming an interior. The interior can be separated into two or more flow paths or flow channels. The two flow paths can be formed by casting having one or more core ties connecting the flow paths during casting. One or more core tie holes can be formed remnant of the core ties during casting in order to fluidly couple the two or more flow paths or flow channels.
FILED Monday, April 03, 2017
APPL NO 15/477335
ART UNIT 3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Foundry Moulding
B22C 9/10 (20130101)

Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/187 (20130101) Original (OR) Class
F01D 9/04 (20130101)
F01D 25/12 (20130101)
F01D 25/32 (20130101)

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2220/30 (20130101)
F05D 2230/211 (20130101)
F05D 2240/304 (20130101)
F05D 2240/307 (20130101)
F05D 2250/141 (20130101)
F05D 2260/202 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022145 Maliniak et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
United States Navy (USN)
APPLICANT(S) United Technologies Corporation (Farmington, Connecticut)
ASSIGNEE(S) Raytheon Technologies Corporation (Farmington, Connecticut)
INVENTOR(S) David Maliniak (Guilford, Connecticut);  Nathan F. Champion (Enfield, Connecticut);  Kenneth A. Frisk (West Hartford, Connecticut)
ABSTRACT A variable area vane arrangement includes a stator vane, a bushing and a vane platform with an aperture. The stator vane rotates about an axis, and includes a shaft that extends along the axis into the aperture. The bushing is connected to the shaft, and is arranged within the aperture between the vane platform and the shaft.
FILED Monday, August 20, 2018
APPL NO 16/105336
ART UNIT 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 17/162 (20130101)

Non-positive-displacement Pumps
F04D 29/563 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2250/14 (20130101)
F05D 2250/73 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022308 Rudrapatna et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
APPLICANT(S) HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
ASSIGNEE(S) HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina)
INVENTOR(S) Nagaraja S. Rudrapatna (Chandler, Arizona);  Ian Critchley (Prescott, Arizona);  Jeffrey Spencer (Tempe, Arizona);  Philip Smalley (Tempe, Arizona)
ABSTRACT A combustor for a turbine engine includes a first liner and a second liner forming a combustion chamber with the first liner. The combustion chamber is configured to receive an air-fuel mixture for combustion therein. The first liner is a first double wall liner with a first wall forming a portion of the combustion chamber and a second wall extending around at least a portion of the first wall to form a liner cavity with the first wall. The first wall defines a first wall orifice and the second wall defines a second wall orifice. The combustor further includes a first insert mounted on the second wall within the second wall orifice and extending through the first wall orifice. The first insert is configured to direct a first air jet through the second wall, through the first wall, and into the combustion chamber.
FILED Thursday, May 31, 2018
APPL NO 15/993986
ART UNIT 3741 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers
F23R 3/002 (20130101)
F23R 3/06 (20130101) Original (OR) Class
F23R 3/50 (20130101)
F23R 2900/00017 (20130101)
F23R 2900/03041 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022318 Prada Bernal et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) Precision Combustion, Inc. (North Haven, Connecticut)
ASSIGNEE(S) PRECISION COMBUSTION, INC. (North Haven, Connecticut)
INVENTOR(S) Julian David Prada Bernal (Middletown, Connecticut);  Francesco Macri (Farmington, Connecticut)
ABSTRACT A gas-fired burner adapted for use on a liquid fuel. A method for essentially smokeless start-up and steady state operation of a gas-fired burner on a liquid fuel. The apparatus integrates a catalytic liquid fuel reformer with a flame burner designed for operation on a gaseous fuel of high Wobbe Index, e.g., natural gas. The method involves reacting a mixture of a liquid fuel and oxidant in a catalytic reformer to obtain a gaseous reformate having a low Wobbe Index; and thereafter combusting the gaseous reformate, optionally augmented with liquid co-fuel and oxidant, in the gas-fired burner under diffusion flame conditions. The invention allows commercial gas-fired appliances to be operated on a liquid fuel, thereby offering advantages in logistics and camp operations.
FILED Wednesday, July 31, 2019
APPL NO 16/527198
ART UNIT 3762 — Refrigeration, Vaporization, Ventilation, and Combustion
CURRENT CPC
Burners
F23D 5/10 (20130101)
F23D 5/126 (20130101)
F23D 2204/10 (20130101)

Feeding Fuel to Combustion Apparatus
F23K 5/22 (20130101)

Domestic Stoves or Ranges; Details of Domestic Stoves or Ranges, of General Application
F24C 5/18 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022378 Tucker et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
APPLICANT(S) Mainstream Engineering Corporation (Rockledge, Florida)
ASSIGNEE(S) Mainstream Engineering Corporation (Rockledge, Florida)
INVENTOR(S) Brian P. Tucker (Orlando, Florida);  Joshua D. Sole (Rockledge, Florida);  Justin J. Hill (Merritt Island, Florida);  Robert P. Scaringe (Rockledge, Florida)
ABSTRACT A window assembly heat transfer system is disclosed in which a window member has a selected transparency to monitored or sensed light wavelengths. One or more passages are provided in the window member for flowing a single-phase or two-phase heat transfer fluid, the passages being optically non-transparent to the monitored or sensed light wavelengths. A mechanism allows either evaporation or condensation of the fluid and/or balancing of a flow of the fluid within the passages. In one embodiment, the window assembly can be made by producing passages in a top surface of a first single plate, optionally producing passages in a bottom surface of a second single plate and bonding the top surface of the first plate to a bottom surface of a second single plate to form the window member with the passage or passages. In another embodiment, the window assembly can be made by providing a core around which the window member material is grown and thereafter removing the core to produce the passage or passages.
FILED Monday, January 20, 2020
APPL NO 16/747038
ART UNIT 2884 — Optics
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 16/56 (20130101)
C23C 16/305 (20130101)

Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor
C30B 25/02 (20130101)
C30B 29/48 (20130101)
C30B 33/08 (20130101)

Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact
F28D 15/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022391 Shipley et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) Textron Systems Corporation (Hunt Valley, Maryland)
ASSIGNEE(S) Textron Systems Corporation (Hunt Valley, Maryland)
INVENTOR(S) Paul Andrew Shipley (Millers, Maryland);  Cameron Mehdi Brand (Towson, Maryland);  Kevin Michael Ayotte (Baltimore, Maryland);  Joshua Stephen Ruck (Baltimore, Maryland);  Benjamin Tyler Cole (Baltimore, Maryland);  William Henry Engel, IV (Cockeysville, Maryland)
ABSTRACT A firearm for firing cased telescoped (CT) ammunition cartridges that includes a split chamber configured to fully support a CT cartridge when it is fired, and that includes i) a dynamic rear chamber portion defining a pocket in a face of a bolt, and ii) a static front chamber portion that is integral to the barrel and separate from the bolt. A cartridge extraction mechanism engages the CT cartridge prior to the CT cartridge being fired, and holds the CT cartridge in the pocket in the bolt face as the bolt moves rearward to pull the CT cartridge out of the static front chamber portion and into an ejection position. An ejector is operable to eject the CT cartridge from the pocket in the face of the bolt when the CT cartridge reaches the ejection position.
FILED Thursday, March 05, 2020
APPL NO 16/809683
ART UNIT 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance
F41A 3/26 (20130101)
F41A 15/14 (20130101) Original (OR) Class

Explosive Charges, e.g for Blasting, Fireworks, Ammunition
F42B 5/045 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022446 Kaehler et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
United States Air Force (USAF)
APPLICANT(S) APPLIED INVENTION, LLC (Burbank, California)
ASSIGNEE(S) APPLIED INVENTION, LLC (Burbank, California)
INVENTOR(S) Adrian Kaehler (Los Feliz, California);  Kjerstin Williams (Los Angeles, California);  Mark E. Duttweiler (Sherman Oaks, California)
ABSTRACT A plan through a space having a near field and a far field is determined. Using a sensor device, measurements of the far field are obtained and stored in an electronic memory. A processor uses the measurements to determine the viability of each far field plan among a plurality of candidate far field plans. The processor also determines a flexibility score for each of the candidate far field plans and selects a composite plan comprising the viable far field plan having a highest flexibility score among the viable candidate far field plans.
FILED Thursday, July 25, 2019
APPL NO 16/522456
ART UNIT 3662 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems
CURRENT CPC
Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit
B60W 30/00 (20130101)

Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry
G01C 21/34 (20130101)
G01C 21/3407 (20130101) Original (OR) Class

Systems for Controlling or Regulating Non-electric Variables
G05D 1/0212 (20130101)
G05D 2201/0213 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022489 Ng et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Surface Warfare Center (NSWC)
Secretary of the Navy (SECNAV)
APPLICANT(S) The United States of America, as represented by the Secretary of the Navy (Crane, Indiana)
ASSIGNEE(S) The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S) Kin Chiu Ng (Fresno, California);  Subrata Sanyal (Eastvale, California)
ABSTRACT The invention relates to a portable multi-spectrometry system for chemical and biological sensing in atmospheric air. A portable, spectrometric system integrates multiple spectroscopy theories, combines their advantageous features, and fills the gaps for their limitations. The combined spectrometry system with operations for PLS, IRAS, MAS, MFS, RSS, and MS, will detect particles and chemicals, directly and sequentially, in the same air-stream.
FILED Thursday, March 28, 2019
APPL NO 16/368171
ART UNIT 2886 — Optics
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 3/42 (20130101)
G01J 3/0272 (20130101)
G01J 3/0294 (20130101) Original (OR) Class
G01J 3/4406 (20130101)
G01J 3/4412 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/65 (20130101)
G01N 21/3103 (20130101)
G01N 21/3504 (20130101)
G01N 21/6404 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 49/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022529 Zheng et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
United States Air Force (USAF)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
Department of Agriculture (USDA)
APPLICANT(S) The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S) The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S) Siyang Zheng (State College, Pennsylvania);  Mauricio Terrones (State College, Pennsylvania);  Yin-Ting Yeh (State College, Pennsylvania);  Yi Tang (State College, Pennsylvania);  Huaguang Lu (State College, Pennsylvania);  Nestor Perea Lopez (State College, Pennsylvania);  Yiqiu Xia (State College, Pennsylvania)
ABSTRACT The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.
FILED Friday, February 07, 2020
APPL NO 16/784507
ART UNIT 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502707 (20130101)
B01L 3/502715 (20130101)
B01L 3/502753 (20130101)
B01L 3/502761 (20130101)
B01L 2200/12 (20130101)
B01L 2200/0668 (20130101)
B01L 2300/12 (20130101)
B01L 2300/041 (20130101)
B01L 2300/0681 (20130101)
B01L 2300/0896 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/405 (20130101) Original (OR) Class
G01N 1/4077 (20130101)
G01N 33/552 (20130101)
G01N 33/54346 (20130101)
G01N 33/56983 (20130101)
G01N 2001/4088 (20130101)
G01N 2333/11 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022533 Bruton et al.
FUNDED BY
Department of Defense (DOD)
Defense Mobility Enterprise (DME)
National Advanced Mobility Consortium (NAMC)
Department of the Army (DOA)
U.S. Army Contracting Command (ACC)
U.S. Army
APPLICANT(S) The Boeing Company (Chicago, Illinois)
ASSIGNEE(S) The Boeing Company (Chicago, Illinois)
INVENTOR(S) Eric Alan Bruton (Lake St. Louis, Missouri);  Loyal Bruce Shawgo (O'Fallon, Missouri)
ABSTRACT A method of controlling a particle size distribution of a filler in an extrudable composition comprises introducing an extrudable composition comprising a polymer matrix material and a filler into an extruder, the filler having a first average particle size that is larger than a target average particle size. The extrudable composition is extruded one or more times using the extruder to reduce the size of the filler from the first average particle size to a reduced average particle size, the reduced average particle size being within 10% of the target average particle size.
FILED Monday, May 06, 2019
APPL NO 16/404297
ART UNIT 2886 — Optics
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/0227 (20130101) Original (OR) Class
G01N 2015/0277 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022541 Chenault
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
APPLICANT(S) Polaris Sensor Technologies, Inc. (Huntsville, Alabama)
ASSIGNEE(S) Polaris Sensor Technologies, Inc. (Huntsville, Alabama)
INVENTOR(S) David B. Chenault (Huntsville, Alabama)
ABSTRACT A method for detecting the presence of foreign fluids on surface comprises estimating an expected polarization response for a foreign fluid desired to be detected. Oil from an oil spill is one such foreign fluid. A polarimeter records raw image data of a surface (e.g., the surface of water) to obtain polarized images of the surface. IR and polarization data products are computed from the polarized images. The IR and polarization data products are converted to multi-dimensional data set to form multi-dimensional imagery. Contrast algorithms are applied to the multi-dimensional imagery to form enhanced contrast images, from which foreign fluids can be automatically detected.
FILED Tuesday, July 30, 2019
APPL NO 16/526503
ART UNIT 2884 — Optics
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/21 (20130101) Original (OR) Class
G01N 25/00 (20130101)
G01N 33/1833 (20130101)
G01N 2021/1793 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/0063 (20130101)
G06K 9/2036 (20130101)

Image Data Processing or Generation, in General
G06T 5/50 (20130101)
G06T 2207/10048 (20130101)
G06T 2207/30181 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022605 Hickman et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) University of Central Florida Research Foundation, Inc. (Orlando, Florida)
ASSIGNEE(S) University of Central Florida Research Foundation, Inc. (Orlando, Florida)
INVENTOR(S) James Hickman (Orlando, Florida);  Lee Kumanchik (Orlando, Florida);  Navaneetha Santhanam (Orlando, Florida)
ABSTRACT Disclosed herein are cell culture analog devices, systems and methods for applying stimuli to components containing different cell types and recording the cell responses before, during, and after a stimulus (for example, a drug, metabolite, toxin, or electrical stimulus) is introduced. Responses can be stored to a database and compared to previous results. By analyzing how each cell type responds to various stimulation parameters, for example, by using multivariate analyses, cell signaling pathway information can be determined or new pathways can be discovered. In some implementations, an individual component interfaces with a specific cell type. This facilitates readout of the cell response to the stimulation. Various components can also interface with each other, such that the behavior of one cell type can affect a cell type in another component. Once assembled, the system is plugged into readout electronics and a programmable electrical stimulator.
FILED Wednesday, August 16, 2017
APPL NO 16/328417
ART UNIT 1799 — Organic Chemistry
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 23/12 (20130101)
C12M 41/46 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/502 (20130101)
G01N 33/5014 (20130101) Original (OR) Class
G01N 33/5029 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022762 Singer et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Chiral Photonics, Inc. (Pine Brook, New Jersey)
ASSIGNEE(S) Chiral Photonics, Inc. (Pine Brook, New Jersey)
INVENTOR(S) Jonathan Singer (New Hope, Pennsylvania);  Victor Il'ich Kopp (Fair Lawn, New Jersey);  Christopher W. Draper (Allendale, New Jersey);  Zhou Shi (Pine Brook, New Jersey);  Norman Chao (Brooklyn, New York)
ABSTRACT An optical fiber connector configured to rotationally align a first optical fiber with a second optical fiber is provided. The connector can include at least two rotational alignment features. At least one of the two rotational alignment features can include at least one ferrule configured to hold at least the first optical fiber.
FILED Wednesday, December 11, 2019
APPL NO 16/710463
ART UNIT 2874 — Optics
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/383 (20130101)
G02B 6/3851 (20130101)
G02B 6/3853 (20130101)
G02B 6/3874 (20130101) Original (OR) Class
G02B 6/3885 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022823 Syllaios
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
APPLICANT(S) University of North Texas (Denton, Texas)
ASSIGNEE(S) University of North Texas (Denton, Texas)
INVENTOR(S) Athanasios J. Syllaios (Denton, Texas)
ABSTRACT switchable optical filter that is based on carrier injection induced semiconductor to metal phase transition (SMT) of vanadium oxide-based (e.g., VO2) thin films may reversibly change from optically transparent to opaque while undergoing such phase transition. Electrical carrier injection may be established by an electric field or by photoexcitation. The SMT may also be induced by a combination of applying an electric field and optical flux. Such a switchable optical filter, when inserted in the optical path of an optical radiation sensor, may be used to control and/or limit high power optical beams, such as a laser beam impinging on one or more sensor elements. Since the SMT may be configured to occur at ultrafast time scales (e.g., approximately 100 femtoseconds), it may also act as a beam shutter and/or as a fast optical beam modulator.
FILED Wednesday, August 08, 2018
APPL NO 16/058759
ART UNIT 2872 — Optics
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/015 (20130101) Original (OR) Class
G02F 2201/38 (20130101)
G02F 2203/01 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023275 Dinan et al.
FUNDED BY
Department of Defense (DOD)
National Security Agency (NSA)
APPLICANT(S) Intel Corporation (Santa Clara, California)
ASSIGNEE(S) Intel Corporation (Santa Clara, California)
INVENTOR(S) James Dinan (Hudson, Massachusetts);  Mario Flajslik (Hudson, Massachusetts);  Timo Schneider (Hudson, Massachusetts)
ABSTRACT Technologies for managing a queue on a compute device are disclosed. In the illustrative embodiment, the queue is managed by a host fabric interface of the compute device. Queue operations such as enqueuing data onto the queue and dequeuing data from the queue may be requested by remote compute devices by sending queue operations which may be processed by the host fabric interface. The host fabric interface may, in some embodiments, fully manage the queue without any assistance from the processor of the compute device. In other embodiments, the processor of the compute device may be responsible for certain tasks, such as garbage collection.
FILED Thursday, February 09, 2017
APPL NO 15/428282
ART UNIT 2195 — Interprocess Communication and Software Development
CURRENT CPC
Electric Digital Data Processing
G06F 9/46 (20130101)
G06F 9/4881 (20130101) Original (OR) Class
G06F 9/5016 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023625 Eck et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S) Raytheon Company (Waltham, Massachusetts)
INVENTOR(S) Christopher R. Eck (Dunedin, Florida);  Cassandra L. Wellman (St. Petersburg, Florida);  Jagannath Chirravuri (Medfield, Massachusetts)
ABSTRACT A computational accelerator architecture facilitates change management of works in a model-based system engineering (MBSE) system in which each of the MBSE works includes a plurality of separately-identifiable statements. A linkage data store stores statement-wise, variable-strength linkages between certain statements of the MBSE works, where the linkages are indicative of associations between those certain statements. A revision control engine detects changes made to statements of MBSE works, and selectively indicates calls for revision of other statements in response to those changes based on respective strengths of linkages associated with the changed statements.
FILED Thursday, January 10, 2019
APPL NO 16/244420
ART UNIT 2194 — Interprocess Communication and Software Development
CURRENT CPC
Electric Digital Data Processing
G06F 16/211 (20190101)
G06F 30/00 (20200101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023808 Jiang et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) HRL LABORATORIES, LLC (Malibu, California)
ASSIGNEE(S) HRL Laboratories, LLC (Malibu, California)
INVENTOR(S) Qin Jiang (Park Oaks, California);  Narayan Srinivasa (Oak Park, California)
ABSTRACT A system to detect a feature in an input image comprising a processor to evaluate a model including: four layers including: a supragranular layer, a granular layer, a first infragranular layer, and a second infragranular layer, each of the layers including a base connection structure including: an excitatory layer including a excitatory neurons arranged in a two dimensional grid; and an inhibitory layer including a inhibitory neurons arranged in a two dimensional grid; within-layer connections between the neurons of each layer in accordance with a Gaussian distribution; between-layer connections between the neurons of different layers, the probability of a neuron of a first layer of the different layers to a neuron of a second layer of the different layers in accordance with a uniform distribution; and input connections from lateral geniculate nucleus (LGN) neurons of an input LGN layer to the granular layer in accordance with a uniform distribution.
FILED Thursday, October 24, 2019
APPL NO 16/663195
ART UNIT 2137 — Memory Access and Control
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6256 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/049 (20130101)
G06N 3/082 (20130101) Original (OR) Class
G06N 3/0635 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023840 Chang et al.
FUNDED BY
Department of Defense (DOD)
National Security Agency (NSA)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S) INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S) Yuan-Chi Chang (Armonk, New York);  Mark D. Feblowitz (Winchester, Massachusetts);  Nagui Halim (Yorktown Heights, New York);  Stuart S. Horn (Southbury, Connecticut);  Edward J. Pring (Yorktown Heights, New York);  Anton V. Riabov (Ann Arbor, Michigan);  Edward W. Shay (White Plains, New York);  Shirin Sohrabi Araghi (Port Chester, New York);  Deepak S. Turaga (Elmsford, New York);  Octavian Udrea (Ossining, New York);  Fang Yuan (Chappaqua, New York);  Peter Zimmer (Danbury, Connecticut)
ABSTRACT Techniques for scenario planning are provided. In one example, a computer-implemented method can comprise analyzing, by a device operatively coupled to a processor, content using a topic model. The content can be associated with a defined source and is related to one or more current events. The computer-implemented method can also comprise determining, by the device, one or more portions of the analyzed content that are relevant to one or more key risk drivers using a risk driver model. The computer-implemented method can also comprise aggregating, by the device, the determined one or more portions into one or more emerging storylines based on values of one or more attributes of the topic model.
FILED Friday, January 27, 2017
APPL NO 15/418377
ART UNIT 3623 — Business Methods - Incentive Programs, Coupons; Operations Research; Electronic Shopping; Health Care; Point of Sale, Inventory, Accounting; Cost/ Price, Reservations, Shipping and Transportation; Business Processing
CURRENT CPC
Electric Digital Data Processing
G06F 16/951 (20190101)

Computer Systems Based on Specific Computational Models
G06N 5/02 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/067 (20130101)
G06Q 10/0635 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024291 Castan Lavilla et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) SRI International (Menlo Park, California)
ASSIGNEE(S) SRI INTERNATIONAL (Menlo Park, California)
INVENTOR(S) Diego Castan Lavilla (Mountain View, California);  Harry Bratt (Mountain View, California);  Mitchell Leigh McLaren (Alderley, Australia)
ABSTRACT In an embodiment, the disclosed technologies include automatically recognizing speech content of an audio stream that may contain multiple different classes of speech content, by receiving, by an audio capture device, an audio stream; outputting, by one or more classifiers, in response to an inputting to the one or more classifiers of digital data that has been extracted from the audio stream, score data; where a score of the score data indicates a likelihood that a particular time segment of the audio stream contains speech of a particular class; where the one or more classifiers use one or more machine-learned models that have been trained to recognize audio of one or more particular classes to determine the score data; using a sliding time window process, selecting particular scores from the score data; using the selected particular scores, determining and outputting one or more decisions as to whether one or more particular time segments of the audio stream contain speech of one or more particular classes; where the one or more decisions are outputted within a real-time time interval of the receipt of the audio stream; where the one or more decisions are used by downstream processing of the audio stream to control any one or more of the following: labeling the audio stream, segmenting the audio stream, diarizing the audio stream.
FILED Wednesday, March 27, 2019
APPL NO 16/366751
ART UNIT 2659 — Linguistics, Speech Processing and Audio Compression
CURRENT CPC
Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding
G10L 15/04 (20130101)
G10L 15/005 (20130101)
G10L 15/08 (20130101) Original (OR) Class
G10L 15/16 (20130101)
G10L 17/06 (20130101)
G10L 17/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024348 Lynch et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) John K. Lynch (West Lafayette, Indiana);  Pedro P. Irazoqui (West Lafayette, Indiana)
ABSTRACT An electronic memory array includes a plurality of memory domains, a current controller, and a selector device. Each memory domain includes a plurality of bit cells. The current controller includes a current controller output electrically connectable to said plurality of memory domains and is configured to control a bit cell current. The selector device is electrically connected to the current controller and the plurality of memory domains. The selector device is configured to selectively electrically connect the current controller output to only a select one of said memory domains, such that the current controller controls only the bit cell current of the bit cells of the select memory domain.
FILED Thursday, February 20, 2020
APPL NO 16/795787
ART UNIT 2824 — Semiconductors/Memory
CURRENT CPC
Static Stores
G11C 7/08 (20130101)
G11C 7/12 (20130101) Original (OR) Class
G11C 7/14 (20130101)
G11C 7/065 (20130101)
G11C 7/106 (20130101)
G11C 7/1051 (20130101)
G11C 11/419 (20130101)
G11C 11/565 (20130101)
G11C 11/4091 (20130101)
G11C 11/4094 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024447 Jonker
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S) Berend T. Jonker (Waldorf, Maryland)
ABSTRACT The invention relates to heterostructures including a layer of a two-dimensional material placed on a multiferroic layer. An ordered array of differing polarization domains in the multiferroic layer produces corresponding domains having differing properties in the two-dimensional material. When the multiferroic layer is ferroelectric, the ferroelectric polarization domains in the layer produce local electric fields that penetrate the two-dimensional material. The local electric fields can influence properties of the two-dimensional material, including carrier density, transport properties, optical properties, surface chemistry, piezoelectric-induced strain, magnetic properties, and interlayer spacing. Methods for producing the heterostructures are provided. Devices incorporating the heterostructures are also provided, including tunable sensors, optical emitters, and programmable logic gates.
FILED Tuesday, November 21, 2017
APPL NO 15/819929
ART UNIT 2819 — Semiconductors/Memory
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/414 (20130101)
G01N 27/4146 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 1/009 (20130101) Original (OR) Class
H01F 10/1933 (20130101)
H01F 10/3222 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 29/24 (20130101)
H01L 29/778 (20130101)
H01L 29/1606 (20130101)
H01L 29/7391 (20130101)
H01L 29/66984 (20130101)
H01L 29/78391 (20140902)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024624 Savanth et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Arm Limited (Cambridge, United Kingdom);  The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S) Arm Limited (Cambridge, United Kingdom);  The Regents of the University of Michigan (Ann Arbor, Michigan)
INVENTOR(S) Parameshwarappa Anand Kumar Savanth (Cambridge, United Kingdom);  Fabrice Blanc (Vinay, France);  David Theodore Blaauw (Ann Arbor, Michigan);  Sechang Oh (Ann Arbor, Michigan);  In Hee Lee (Ann Arbor, Michigan)
ABSTRACT In a particular implementation, an apparatus to control clamping devices includes a first control circuit and a second control circuit. The first control circuit is responsive to a detection signal and generates a first drive signal to control a body diode of a clamping device. The second control circuit is responsive to the detection signal and generates a second drive signal to control the gate terminal of the clamping device.
FILED Tuesday, July 24, 2018
APPL NO 16/044231
ART UNIT 2839 — Organic Chemistry
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/0277 (20130101) Original (OR) Class

Emergency Protective Circuit Arrangements
H02H 1/0007 (20130101)
H02H 9/046 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024790 Onen et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Research Office (ARO)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Oguzhan Murat Onen (Boston, Massachusetts);  Marco Turchetti (Cambridge, Massachusetts);  Karl K. Berggren (Arlington, Massachusetts);  Brenden Butters (Cambridge, Massachusetts);  Mina Bionta (Somerville, Massachusetts);  Phillip Donald Keathley (Natick, Massachusetts)
ABSTRACT A device that is a combination of a superconducting nanowire single-photon detector and a superconducting multi-level memory. These devices can be used to count a number of photons impinging on the device through single-photon to single-flux conversion. Electrical characterization of the device demonstrates single-flux quantum (SFQ) separated states. Optical measurements using attenuated laser pulses with different mean photon number, pulse energies and repetition rates are shown to differentiate single-photon detection from other possible phenomena, such as multiphoton detection and thermal activation. Array devices and methods are also discussed.
FILED Monday, August 24, 2020
APPL NO 17/000959
ART UNIT 2818 — Semiconductors/Memory
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 1/42 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/101 (20130101)
H01L 39/10 (20130101) Original (OR) Class
H01L 39/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024848 Yu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) The Texas A and M University System (College Station, Texas)
ASSIGNEE(S) The Texas A and M University System (College Station, Texas)
INVENTOR(S) Choongho Yu (College Station, Texas);  Suk Lae Kim (College Station, Texas)
ABSTRACT An energy storage device and method of forming and operating the same. In one embodiment, the energy storage device includes a positive electrode including a first redox polymer deposited on a first conductive porous substrate. The energy storage device also includes a solid-state polyelectrolyte separator operative as a voltage generator, and a negative electrode including a second redox polymer deposited on a second conductive porous substrate, thereby forming an electrochemical cell.
FILED Friday, February 17, 2017
APPL NO 15/999855
ART UNIT 1729 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 11/26 (20130101)
H01G 11/36 (20130101)
H01G 11/52 (20130101)
H01G 11/86 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/606 (20130101) Original (OR) Class
H01M 4/663 (20130101)
H01M 10/08 (20130101)
H01M 10/36 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024876 Xu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Department of the Army (DOA)
United States Army (USA)
National Aeronautics and Space Administration (NASA)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Giner, Inc. (Newton, Massachusetts)
ASSIGNEE(S) GINER, INC. (Newton, Massachusetts)
INVENTOR(S) Hui Xu (Acton, Massachusetts);  Jarrod D. Milshtein (Cambridge, Massachusetts);  Katherine Harrison (Arlington, Massachusetts);  Mario Moreira (Hudson, Massachusetts);  Brian Rasimick (Boston, Massachusetts)
ABSTRACT A composite membrane that is suitable for use in an electrochemical cell, an electrochemical cell including the composite membrane, and a method of making the composite membrane. In one embodiment, the composite membrane includes a porous support and a solid electrolyte. The porous support is a unitary structure made of a polymer that is non-conductive to ions. The porous support is shaped to include a plurality of straight-through pores. The solid electrolyte has alkali ion conductivity and preferably completely fills at least some of the pores of the porous support. A variety of techniques may be used to load the solid electrolyte into the pores. According to one technique, the solid electrolyte is melted and then poured into the pores of the porous support. Upon cooling, the electrolyte re-solidifies, forming a monolithic structure within the pores of the porous support.
FILED Wednesday, November 01, 2017
APPL NO 15/801118
ART UNIT 1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/02 (20130101)
H01M 4/13 (20130101)
H01M 10/052 (20130101)
H01M 10/0486 (20130101)
H01M 10/0562 (20130101) Original (OR) Class
H01M 2004/027 (20130101)
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024937 Wu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S) Dong Ho Wu (Olney, Maryland);  Louis M. Pecora (Alexandria, Virginia);  Christopher Kim (Lorton, Virginia)
ABSTRACT Systems and methods are provided for enhancing the terahertz power output of a terahertz beam while increasing its stability and its beam polarity by implementing a pair of pinched ripple electrodes and a small flat section in the middle of each electrode. By using tight control over the design parameters and by exploiting the plasmonic effect and the superradiance effect, systems and methods according to embodiments of the present disclosure can achieve a dramatic improvement in the terahertz output power and beam quality as well as the beam stability.
FILED Friday, May 31, 2019
APPL NO 16/427701
ART UNIT 2884 — Optics
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/09 (20130101)
H01L 31/108 (20130101)
H01L 31/0224 (20130101)
H01L 31/0304 (20130101)
H01L 31/022408 (20130101)

Antennas, i.e Radio Aerials
H01Q 1/02 (20130101) Original (OR) Class

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 1/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024950 Hening et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
Space and Naval Warfare Systems (SPAWAR)
APPLICANT(S) United States Government as represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S) United States of America as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S) Alexandru Hening (San Diego, California);  Ryan P. Lu (San Diego, California);  Ayax D. Ramirez (Chula Vista, California);  Britanny Lynn (San Diego, California)
ABSTRACT An antenna comprising: a radio frequency (RF) coupler; a transceiver communicatively coupled to the RF coupler; a laser configured to generate a plurality of femtosecond laser pulses so as to create, without the use of high voltage electrodes, a laser-induced plasma filament (LIPF) in atmospheric air, wherein the laser is operatively coupled to the RF coupler such that RF energy is transferred between the LIPF and the RF coupler; and wherein the laser is configured to modulate a characteristic of the laser pulses at a rate within the range of 1 Hz to 1 GHz so as to modulate a conduction efficiency of the LIPF thereby creating a variable impedance LIPF antenna.
FILED Friday, November 30, 2018
APPL NO 16/206280
ART UNIT 2644 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC
Antennas, i.e Radio Aerials
H01Q 1/26 (20130101) Original (OR) Class
H01Q 3/01 (20130101)
H01Q 9/16 (20130101)
H01Q 19/108 (20130101)

Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams
H05H 1/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11025215 Chandrakumar et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Hariprasad Chandrakumar (Los Angeles, California);  Dejan Markovic (Los Angeles, California)
ABSTRACT Neuromodulation systems in accordance with embodiments of the invention can use a feed-forward common-mode cancellation (CMC) path to attenuate common-mode (CM) artifacts appearing at a voltage input, thus allowing for the simultaneous recording of neural data and stimulation of neurons. In several embodiments of the invention, the feed-forward CMC path is utilized to attenuate the common-mode swings at Vin,CM, which can restore the linear operation of the front-end for differential signals. In several embodiments, the neuromodulation system may utilize an anti-alias filter (AAF) that includes a duty-cycles resistor (DCR) switching at a first frequency f1, followed by a DCR switching at a second frequency f2. The AAF allows for a significantly reduced second frequency f2 that enables the multi-rate DCR to increase the maximum realizable resistance, which is dependent upon the frequency ratio f1/f2.
FILED Thursday, December 07, 2017
APPL NO 16/467456
ART UNIT 2843 — Optics
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/24 (20210101)
A61B 5/7217 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 21/00 (20130101)

Amplifiers
H03F 1/26 (20130101)
H03F 1/56 (20130101)
H03F 3/45475 (20130101) Original (OR) Class
H03F 2200/261 (20130101)
H03F 2200/459 (20130101)
H03F 2203/45138 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11025273 Sample
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia)
INVENTOR(S) John T. Sample (Pearl River, Louisiana)
ABSTRACT Systems and methods are provided for reducing error in data compression and decompression when data is transmitted over low bandwidth communication links, such as satellite links. Embodiments of the present disclosure provide systems and methods for variable block size compression for gridded data, efficiently storing null values in gridded data, and eliminating growth of error in compressed time series data.
FILED Tuesday, April 09, 2019
APPL NO 16/378766
ART UNIT 2111 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC
Electric Digital Data Processing
G06F 11/076 (20130101)
G06F 11/0709 (20130101)

Coding; Decoding; Code Conversion in General
H03M 7/6041 (20130101) Original (OR) Class

Transmission
H04B 7/185 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11025287 Jensen
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) Rockwell Collins, Inc. (Cedar Rapids, Iowa)
ASSIGNEE(S) Rockwell Collins, Inc. (Cedar Rapids, Iowa)
INVENTOR(S) Dana J. Jensen (Marion, Iowa)
ABSTRACT Embodiments of the inventive concepts disclosed herein are directed to a system for cancelling interference. The system may include a first antenna and a second antenna spatially separated from the first antenna. The system may include a first time delay unit, coupled to the first antenna, and configured to apply a first time delay and first power gain on a first signal received by the first antenna. The system may include a control circuit, coupled to the first time delay unit, and configured to determine the first time delay and first power gain to cause a modified version of the first signal and a second signal, received by the second antenna, to be aligned in time and power levels.
FILED Monday, February 17, 2020
APPL NO 16/792350
ART UNIT 2646 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC
Transmission
H04B 1/126 (20130101) Original (OR) Class
H04B 1/1018 (20130101)
H04B 1/1036 (20130101)
H04B 1/1081 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11025600 Medard et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Muriel Medard (Belmont, Massachusetts);  Prakash Narayana Moorthy (Framingham, Massachusetts);  Vitaly Abdrashitov (Somerville, Massachusetts)
ABSTRACT Methods for encoding a file and de-duplicating a coded packet of the file are presented. The encoding method includes: identifying a file to be stored; encoding the file to generate a plurality of coded packets; generating a hash code associated with the file; distributing the plurality of coded packets to a plurality of storage nodes; and storing the hash code associated with the file in a hash server. The de-duplicating method includes: receiving a coded packet at a storage node; retrieving a hash code, from the hash server, corresponding to the coded packet; determining whether the coded packet has been stored in the storage node based upon the hash code; in response to determination that the coded packet has being stored, discarding the coded packet; and in response to determination that the coded packet has not being stored, storing the coded packet in the storage node.
FILED Thursday, November 08, 2018
APPL NO 16/184272
ART UNIT 2493 — Cryptography and Security
CURRENT CPC
Electric Digital Data Processing
G06F 16/256 (20190101)
G06F 16/1827 (20190101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 41/12 (20130101)
H04L 61/103 (20130101)
H04L 61/2007 (20130101)
H04L 61/6086 (20130101)
H04L 63/0471 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11025661 Soroush et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S) Palo Alto Research Center Incorporated (Palo Alto, California)
INVENTOR(S) Hamed Soroush (San Jose, California);  Shantanu Rane (Menlo Park, California)
ABSTRACT One embodiment provides a method for facilitating security in a system of networked components. During operation, the system constructs a configuration graph that stores a first set of relationships between configuration parameters within a component and a second set of relationships between configuration parameters across different components. A relationship corresponds to a constraint and is indicated by one or more of: a range for a configuration parameter; and a conjunction or a disjunction of logical relationships between two or more configuration parameters. The system generates a set of candidate configuration parameter values that satisfy the constraints of the relationships in the configuration graph. The system selects, from the set of candidate configuration parameter values, a first set of configuration parameter values that optimizes a security objective function.
FILED Thursday, December 13, 2018
APPL NO 16/219774
ART UNIT 2497 — Cryptography and Security
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 41/22 (20130101)
H04L 41/0816 (20130101)
H04L 41/0823 (20130101)
H04L 43/045 (20130101)
H04L 63/20 (20130101)
H04L 63/1433 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11026351 Kulkarni et al.
FUNDED BY
Department of Defense (DOD)
National Security Agency (NSA)
APPLICANT(S) Intel Corporation (Santa Clara, California)
ASSIGNEE(S) Intel Corporation (Santa Clara, California)
INVENTOR(S) Devdatta P. Kulkarni (Olympia, Washington);  Richard J. Dischler (Bolton, Massachusetts)
ABSTRACT The present disclosure describes embodiments of apparatuses and methods related to a computing apparatus with a closed cooling loop thermally coupled to one or more processors disposed on a circuit board of the computing apparatus. The closed cooling loop circulates a dielectric fluid to absorb heat from the processor. A portion of the dielectric fluid is evaporated from the processor heat absorbed by the dielectric fluid. A heat exchanger is coupled to the circuit board and thermally coupled to the closed cooling loop. The heat exchanger is to include a coolant flow to remove heat from the dielectric fluid circulated through the portion of the closed cooling loop thermally coupled to the heat exchanger. A vapor portion of the dielectric fluid is condensed from the heat removed by the coolant flow. Other embodiments may be described and/or claimed.
FILED Friday, September 25, 2015
APPL NO 15/754957
ART UNIT 2835 — Electrical Circuits and Systems
CURRENT CPC
Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/181 (20130101)
H05K 1/0203 (20130101)
H05K 7/20327 (20130101)
H05K 7/20809 (20130101) Original (OR) Class
H05K 7/20818 (20130101)
H05K 2201/064 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11026358 Zang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
U.S. Air Force
APPLICANT(S) Software Defined Technologies Inc. (Carlsbad, California)
ASSIGNEE(S) SOFTWARE DEFINED TECHNOLOGIES, INC (Carlsbad, California)
INVENTOR(S) De Yu Zang (Irvine, California);  Michael M. Salour (Carlsbad, California);  James G. Grote (Yellow Spring, Ohio)
ABSTRACT An electromagnetic interference (EMI) shielded device which includes an object to be shielded and an EMI shielding material encompassing the object. The EMI shielding material is made up of, but not limited to a broadband biopolymer or polymer dissolved in organic solvents, and metal and carbon-based nano-powders or nanoparticles. The specific makeup of the shielding material and fabrication procedure of the shielding material is also included herein.
FILED Monday, February 25, 2019
APPL NO 16/284507
ART UNIT 1712 — Coating, Etching, Cleaning, Single Crystal Growth
CURRENT CPC
Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 5/32 (20130101)
C09D 199/00 (20130101)

Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/0209 (20130101)
H05K 1/0216 (20130101)
H05K 3/1283 (20130101)
H05K 9/009 (20130101)
H05K 9/0022 (20130101)
H05K 9/0083 (20130101) Original (OR) Class
H05K 2201/0257 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 11020042 Arnold et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
APPLICANT(S) KNOW BIOLOGICAL, INC. (Milton, Georgia);  National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S) Know Biological, Inc. (Milton, Georgia);  National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S) Gary Stephen Arnold (Cumming, Georgia);  Matthew Wallace Moorman (Albuquerque, New Mexico);  Joshua Jonathan Whiting (Albuquerque, New Mexico)
ABSTRACT Example aspects of a collector for a seizure detection device, a seizure detection device, and a method of detecting a seizure are disclosed. The collector for a seizure detection device can comprise a collector material configured to collect volatile organic compounds given off from a patient's skin; a wrapping configured to isolate the collector material from an external environment; a heater comprising a heating element, the heating element configured to emit a thermal pulse to desorb the volatile organic compounds from the collector material; and a mesh layer configured to prevent the collector material from contacting the patient's skin, wherein the collector material is received between the wrapping and the mesh layer.
FILED Thursday, May 14, 2020
APPL NO 16/874229
ART UNIT 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/443 (20130101)
A61B 5/4094 (20130101) Original (OR) Class
A61B 5/6831 (20130101)
A61B 5/6833 (20130101)
A61B 10/00 (20130101)
A61B 2010/0083 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 30/00 (20130101)
G01N 30/20 (20130101)
G01N 30/64 (20130101)
G01N 30/80 (20130101)
G01N 2030/025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020507 Maitland et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California);  THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas)
ASSIGNEE(S) LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California);  THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas)
INVENTOR(S) Duncan J. Maitland (College Station, Texas);  Todd Lawrence Landsman (College Station, Texas);  Tyler Joseph Touchet (Cypress, Texas);  Elizabeth L. Cosgriff-Hernandez (College Station, Texas);  Thomas S. Wilson (San Leandro, California)
ABSTRACT An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (Tg) of the SMP foam to below 25° C. Other embodiments are described herein.
FILED Thursday, March 14, 2019
APPL NO 16/353793
ART UNIT 3781 — Body Treatment, Kinestherapy, and Exercising
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 13/00017 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 15/18 (20130101) Original (OR) Class
A61L 15/26 (20130101)
A61L 15/26 (20130101)
A61L 15/46 (20130101)
A61L 15/425 (20130101)
A61L 24/0015 (20130101)
A61L 24/0036 (20130101)
A61L 24/0094 (20130101)
A61L 24/0094 (20130101)
A61L 2300/106 (20130101)
A61L 2300/404 (20130101)
A61L 2400/16 (20130101)

Compositions of Macromolecular Compounds
C08L 75/04 (20130101)
C08L 75/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020711 Lin et al.
FUNDED BY
Department of Energy (DOE)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Xiao-Min Lin (Naperville, Illinois);  Kun Wu (Naperville, Illinois);  Subramanian Sankaranarayanan (Naperville, Illinois)
ABSTRACT A membrane for filtering one or more hydrophobic organic contaminants can include a porous nanostructure that includes one or more of a metal, a metal oxide, and a metal alloy nanostructure component functionalized with one or more amphiphilic ligands.
FILED Friday, September 28, 2018
APPL NO 16/147534
ART UNIT 1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC
Separation
B01D 61/08 (20130101)
B01D 67/0093 (20130101)
B01D 69/125 (20130101)
B01D 71/022 (20130101) Original (OR) Class
B01D 2239/0414 (20130101)
B01D 2257/70 (20130101)
B01D 2321/168 (20130101)
B01D 2323/36 (20130101)
B01D 2323/40 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)
B82Y 40/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020797 Pascall et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S) Andrew J. Pascall (Livermore, California);  Joshua David Kuntz (Livermore, California);  Scott K. McCall (Livermore, California)
ABSTRACT A system is disclosed for printing a component. The system may have a nozzle controlled for movement within a plane. The nozzle may be configured to dispense a molten metal. A substrate may be positioned within a reservoir. The substrate may receive the molten metal to form the component in a printing operation. A heated barrier material in a molten state may be contained within the reservoir for forming a liquid barrier between an atmosphere and the substrate. The nozzle has a tip which is submerged within the liquid barrier while dispensing the molten metal during the printing operation. The liquid barrier forms a barrier between an atmosphere in a vicinity of the substrate and the substrate.
FILED Tuesday, September 25, 2018
APPL NO 16/141437
ART UNIT 1733 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Casting of Metals; Casting of Other Substances by the Same Processes or Devices
B22D 23/003 (20130101) Original (OR) Class
B22D 45/00 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020933 Hsu et al.
FUNDED BY
Department of Energy (DOE)
National Energy Technology Laboratory (NETL)
APPLICANT(S) The George Washington University (Washington, District of Columbia)
ASSIGNEE(S) The George Washington University (Washington, District of Columbia)
INVENTOR(S) Stephen M. Hsu (Germantown, Maryland);  Yang Jing (Washington, District of Columbia);  Yufei Mo (Washington, District of Columbia);  Dongyun Hua (Washington, District of Columbia);  Ming Chen (Washington, District of Columbia)
ABSTRACT The present invention relates to techniques for lowering friction between moving surfaces of, for example, an internal combustion engine. Friction reduction is achieved by adding texture modifications to surfaces that come in contact with each other. Texture modifications that reduce friction in accordance with the present invention include dimples of varying geometries and depths ion the surfaces of components. The present invention also relates to the fabrication technique for applying the texture to the surfaces. In another embodiment, the patterned soft mask is applied onto a large surface (flat or curved including cylindrical rollers surfaces) to be followed by electrochemical etching to imprint the textures onto the component And, in another embodiment, a diamond-like-carbon (DLC) film may be applied to the turbine component to also reduce friction.
FILED Friday, March 01, 2019
APPL NO 16/290648
ART UNIT 1788 — Miscellaneous Articles, Stock Material
CURRENT CPC
Processes for Applying Fluent Materials to Surfaces, in General
B05D 5/08 (20130101)

Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 3/30 (20130101) Original (OR) Class

Non-mechanical Removal of Metallic Material From Surface; Inhibiting Corrosion of Metallic Material or Incrustation in General; Multi-step Processes for Surface Treatment of Metallic Material Involving at Least One Process Provided for in Class C23 and at Least One Process Covered by Subclass C21D or C22F or Class C25
C23F 1/02 (20130101)

Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines
F02F 1/20 (20130101)

Indexing Scheme Relating to Materials, Material Properties or Material Characteristics for Machines, Engines or Pumps Other Than Non-positive-displacement Machines or Engines
F05C 2253/08 (20130101)
F05C 2253/083 (20130101)

Technical Subjects Covered by Former US Classification
Y10T 428/24355 (20150115)
Y10T 428/24851 (20150115)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020939 Pintauro
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S) VANDERBILT UNIVERSITY (Nashville, Tennessee)
INVENTOR(S) Peter N. Pintauro (Nashville, Tennessee)
ABSTRACT Nanofiber electrodes for electrochemical devices and fabricating methods of the same are disclosed. In one embodiment, the method includes forming a liquid mixture containing a catalyst, a first polymer of perfluoro sulfonic acid and a second polymer of polyethylene oxide, the first polymer of perfluoro sulfonic acid being pre-treated to remove protons in the first polymer by exchange with a cation species like Na+; and electro spinning the liquid mixture to generate electro spun fibers and deposit the generated fibers on a collector substrate to form a fiber electrode mat comprising a network of fibers, where each fiber has a plurality of particles of the catalyst distributed thereon.
FILED Friday, November 16, 2018
APPL NO 16/764504
ART UNIT 1724 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 13/02 (20130101) Original (OR) Class

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/8652 (20130101)
H01M 4/8657 (20130101)
H01M 4/8663 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021274 Judd et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Laboratory (LANL)
Los Alamos National Security, LLC (LANS)
National Nuclear Security Administration (NNSA)
Triad National Security, LLC (Triad)
APPLICANT(S) Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S) Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S) Stephen Judd (Los Alamos, New Mexico);  Nicholas Dallmann (Los Alamos, New Mexico);  Kevin McCabe (Santa Fe, New Mexico);  Donald Enemark (Los Alamos, New Mexico);  Michael Proicou (Los Alamos, New Mexico);  Daniel Seitz (Los Alamos, New Mexico)
ABSTRACT Small cubesat systems may be available for a lower cost, have a higher reliability, and be much simpler to use than conventional cubesats. A complete turnkey system solution may be provided, including the ground station and remote field units. The satellite, ground station, and field unit may be provided separately as kits that are ready to go out-of-the-box as soon as they arrive. This enables universities, researchers, and hobbyists to obtain and deploy their own functional satellites. Furthermore, theoretical designs and functionality may be rapidly prototyped and demonstrated, which allows for proof-of-concept without needing to build a larger, more expensive satellite system and hope that the new design or functionality works as intended.
FILED Thursday, September 08, 2016
APPL NO 15/259152
ART UNIT 3644 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/641 (20130101)
B64G 1/646 (20130101) Original (OR) Class
B64G 2001/1092 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021391 Ewsuk
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S) Kevin G. Ewsuk (Albuquerque, New Mexico)
ABSTRACT The present invention relates to glass composites, including filled glass composites and uses thereof. In particular examples, the composites provide improved thermal expansion characteristics. Also described are methods of forming such composites, such as by adding a particle filler to a glass mixture.
FILED Monday, December 16, 2019
APPL NO 16/715709
ART UNIT 1731 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Manufacture, Shaping, or Supplementary Processes
C03B 32/02 (20130101)

Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials
C03C 3/097 (20130101) Original (OR) Class
C03C 8/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021441 Stahl et al.
FUNDED BY
Department of Energy (DOE)
Pacific Northwest National Laboratory (PNNL)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Shannon S. Stahl (Madison, Wisconsin);  James B. Gerken (Madison, Wisconsin)
ABSTRACT Substituted hydroquinones and quinones and methods of synthesizing such compounds are disclosed herein. The substituted hydroquinones have the formula:
while the substituted quinones have the corresponding oxidized structure (1,4-benzoquinones). One, two, three, or all four of R1, R2, R3 and R4 comprise a thioether moiety and a sulfonate moiety, and wherein each R1, R2, R3 and R4 that does not comprise a thioether and a sulfonate moiety sulfonate moiety is independently a hydrogen, an alkyl or an electron withdrawing group. The substituted hydroquinones and quinones are soluble in water, stable in aqueous acid solutions, and have a high reduction potential in the oxidized form. Accordingly, they can be used as redox mediators in emerging technologies, such as in mediated fuel cells or organic-mediator flow batteries.
FILED Wednesday, March 18, 2020
APPL NO 16/822189
ART UNIT 1626 — Organic Chemistry
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 309/42 (20130101) Original (OR) Class
C07C 319/14 (20130101)
C07C 323/66 (20130101)

Heterocyclic Compounds
C07D 209/48 (20130101)
C07D 231/18 (20130101)
C07D 285/14 (20130101)
C07D 487/04 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 8/188 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021516 Ulijn et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
U.S. Air Force
Department of Energy (DOE)
UChicago Argonne, LLC (UCHICAGO)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
Division of Materials Research (DMR)
APPLICANT(S) Research Foundation of the City University of New York (New York, New York);  University of Strathclyde (Glasgow, United Kingdom);  Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S) Research Foundation of the City University of New York (New York, New York);  University of Strathclyde (Glasgow, United Kingdom);  Carnegie Mellon University (Pittsburgh, Pennsylvania)
INVENTOR(S) Rein V. Ulijn (New York, New York);  Ayala Lampel (Bronx, New York);  Tell Tuttle (Glasgow, United Kingdom);  Gary Scott (Glasgow, United Kingdom);  Scott McPhee (New York, New York);  Christopher Bettinger (Pittsburgh, Pennsylvania)
ABSTRACT A self-assembling peptide is provided that is enzymatically oxidized to form a polymeric pigment. The monomeric peptide has three amino acids (tyrosine (Y), one phenylalanine (F), and one aspartic acid (D) or one lysine (K)) and, following self-assembly and treatment with a tyrosinase enzyme oxidizes and polymerizes into a material with predetermined properties.
FILED Monday, September 11, 2017
APPL NO 16/332231
ART UNIT 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)

Peptides
C07K 5/0812 (20130101) Original (OR) Class
C07K 5/0819 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 69/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021523 Lagarias et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) John Clark Lagarias (Davis, California);  Nathan Clarke Rockwell (Davis, California)
ABSTRACT The present invention provides a protein fusion construct comprising a far-red cyanobacteriochrome (CBCR) domain linked to a heterologous domain, wherein the far-red CBCR domain comprises a CBCR polypeptide and a tetrapyrrole chromophore. The invention also provides nucleic acids, expression cassettes, vectors, and host cells for expression of the far-red CBCR protein fusion constructs. Methods for detecting cellular components, methods for imaging biological structures, and method for modulating cellular processes using the protein fusion constructs are also provided.
FILED Wednesday, August 22, 2018
APPL NO 16/109613
ART UNIT 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0045 (20130101)
A61K 49/0056 (20130101)

Peptides
C07K 14/36 (20130101) Original (OR) Class
C07K 14/195 (20130101)
C07K 2319/60 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/62 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021525 Chou et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Berkeley National Laboratory (LBNL)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Howard H. Chou (Berkeley, California);  Jay D. Keasling (Berkeley, California);  Sergey Zotchev (Trondheim, Norway)
ABSTRACT The present invention provides for a synthetic transcription factor (TF) comprising a first peptide capable of binding a target ligand, a second peptide capable of binding a target DNA, and a peptide linker linking the first and second peptides. The present invention also provide for a system for modulating the mutagenesis frequency of a host cell. The host cell has a mutator rate (R) which is inversely proportional to a phenotypic trait (P).
FILED Wednesday, June 10, 2015
APPL NO 14/735985
ART UNIT 1699 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Peptides
C07K 14/4702 (20130101) Original (OR) Class
C07K 2319/00 (20130101)
C07K 2319/70 (20130101)
C07K 2319/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021615 Sampathkumaran et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) INNOSENSE LLC (Torrance, California)
ASSIGNEE(S) INNOSENSE LLC (Torrance, California)
INVENTOR(S) Uma Sampathkumaran (Torrance, California);  Kevin H. Yu (Temple City, California);  Raymond Winter (Riverside, California)
ABSTRACT Materials are disclosed for the safe sequestration and removal of hazardous contaminants from a surface. The materials can be sprayed, rolled, painted, brushed or dip coated onto any surface and allowed to dry and/or cure at room temperature or drying/curing can be accelerated by the application of heat to form a coating that entraps the contaminant therein. The coating and the entrapped contaminant can then peeled from the surface and safely disposed of to minimize hazardous waste. The coating includes a colorimetric additive that is specific to the contaminant, the coating and the contaminant producing a visual indication of contamination.
FILED Wednesday, May 31, 2017
APPL NO 15/610219
ART UNIT 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 5/20 (20130101) Original (OR) Class
C09D 5/32 (20130101)
C09D 101/28 (20130101)
C09D 175/04 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/78 (20130101)
G01N 21/94 (20130101)
G01N 31/22 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021661 Strohm et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
APPLICANT(S) James J. Strohm (West Richland, Washington);  John C. Linehan (Richland, Washington);  Benjamin Q. Roberts (Richland, Washington);  Douglas L. McMakin (Richland, Washington);  David M. Sheen (Richland, Washington);  Jeffrey W. Griffin (Kennewick, Washington);  James A. Franz (Kennewick, Washington);  Charlene Franz (Kennewick, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) James J. Strohm (West Richland, Washington);  John C. Linehan (Richland, Washington);  Benjamin Q. Roberts (Richland, Washington);  Douglas L. McMakin (Richland, Washington);  David M. Sheen (Richland, Washington);  Jeffrey W. Griffin (Kennewick, Washington);  James A. Franz (Kennewick, Washington)
ABSTRACT Conversion of heavy fossil hydrocarbons (HFH) to a variety of value-added chemicals and/or fuels can be enhanced using microwave (MW) and/or radio-frequency (RF) energy. Variations of reactants, process parameters, and reactor design can significantly influence the relative distribution of chemicals and fuels generated as the product. In one example, a system for flash microwave conversion of HFH includes a source concentrating microwave or RF energy in a reaction zone having a pressure greater than 0.9 atm, a continuous feed having HFH and a process gas passing through the reaction zone, a HFH-to-liquids catalyst contacting the HFH in at least the reaction zone, and dielectric discharges within the reaction zone. The HFH and the catalyst have a residence time in the reaction zone of less than 30 seconds. In some instances, a plasma can form in or near the reaction zone.
FILED Tuesday, February 21, 2012
APPL NO 13/401216
ART UNIT 1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/088 (20130101)
B01J 19/0093 (20130101)
B01J 19/126 (20130101)
B01J 2219/0086 (20130101)
B01J 2219/00792 (20130101)
B01J 2219/00822 (20130101)
B01J 2219/00826 (20130101)
B01J 2219/00835 (20130101)
B01J 2219/0894 (20130101)
B01J 2219/00941 (20130101)
B01J 2219/1215 (20130101)
B01J 2219/1227 (20130101)
B01J 2219/1239 (20130101)
B01J 2219/1245 (20130101)
B01J 2219/1269 (20130101)
B01J 2219/1272 (20130101)

Cracking Hydrocarbon Oils; Production of Liquid Hydrocarbon Mixtures, e.g by Destructive Hydrogenation, Oligomerisation, Polymerisation; Recovery of Hydrocarbon Oils From Oil-shale, Oil-sand, or Gases; Refining Mixtures Mainly Consisting of Hydrocarbons; Reforming of Naphtha; Mineral Waxes
C10G 1/00 (20130101)
C10G 1/02 (20130101)
C10G 1/08 (20130101)
C10G 9/24 (20130101)
C10G 15/08 (20130101)
C10G 32/02 (20130101) Original (OR) Class

Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams
H05H 1/46 (20130101)
H05H 2001/4622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021721 Beckham et al.
FUNDED BY
Department of Energy (DOE)
Battelle Memorial Institute (BATTELLE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
Pacific Northwest National Laboratory (PNNL)
UT-Battelle, LLC (UT-BATTELLE)
Oak Ridge National Laboratory (ORNL)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado);  Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen (Aachen, Germany);  University of Stuttgart (Stuttgart, Germany)
ASSIGNEE(S) Alliance for Sustainable Energy, LLC (Golden, Colorado);  University of Stuttgart (Stuttgart, Germany);  UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Gregg Tyler Beckham (Golden, Colorado);  Mary Ann Franden (Centennial, Colorado);  Lahiru N. Jayakody (Wheat Ridge, Colorado);  Nick Johannes Petrus Wierckx (Bemelen, Netherlands);  Janosch Alexander Klebensberger (Stuttgart, Germany);  Lars Mathias Blank (Dortmund, Germany);  Wing-Jin Li (Cologne, Germany);  Bernhard Hauer (Stuttgart, Germany);  Nicholas S. Cleveland (Golden, Colorado);  William E. Michener (Golden, Colorado);  Jason Michael Whitham (Raleigh, North Carolina)
ABSTRACT Presented herein are genetically engineered Pseudomonas strains capable of metabolizing ethylene glycol and producing polyhydroxyalkanoates.
FILED Friday, July 20, 2018
APPL NO 16/041371
ART UNIT 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
C12N 9/0006 (20130101)
C12N 9/1022 (20130101)
C12N 15/52 (20130101)
C12N 2500/50 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/625 (20130101) Original (OR) Class

Enzymes
C12Y 101/03015 (20130101)
C12Y 202/01005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022028 Lusardi
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency Energy (ARPAE)
APPLICANT(S) Caterpillar Inc. (Deerfield, Illinois)
ASSIGNEE(S) Caterpillar Inc. (Peoria, Illinois)
INVENTOR(S) Christopher Lusardi (Peoria, Illinois)
ABSTRACT An engine system includes an internal combustion engine having an intake passage, a first set of combustion chambers, a second set of combustion chambers, a first exhaust passage fluidly connected to the first set of combustion chambers, and a second exhaust passage fluidly connected to the second set of combustion chambers. The engine system includes a first turbocharger including a first compressor and a first turbine. The engine system also includes a second turbocharger including a second compressor and a second turbine, the second compressor connected in series with the first compressor, and the second turbine being in fluid communication with the second exhaust passage. The first and second turbines are connected in parallel such that the first turbine only receives exhaust flow from the first set of combustion chambers, and the second turbine only receives exhaust flow from the second set of combustion chambers.
FILED Tuesday, May 07, 2019
APPL NO 16/405600
ART UNIT 3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/14 (20130101)

Internal-combustion Piston Engines; Combustion Engines in General
F02B 37/001 (20130101) Original (OR) Class
F02B 37/013 (20130101)
F02B 37/24 (20130101)

Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof
F02M 26/08 (20160201)

Non-positive-displacement Pumps
F04D 29/2216 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 8/04111 (20130101)
H01M 2008/1293 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022429 Stull et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Laboratory (LANL)
Los Alamos National Security, LLC (LANS)
National Nuclear Security Administration (NNSA)
Triad National Security, LLC (Triad)
APPLICANT(S) Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S) Triad National Security, LLC (Los Alamos, New Mexico)
INVENTOR(S) Nicholas D. Stull (Los Alamos, New Mexico);  Eric Brian Flynn (Los Alamos, New Mexico);  Matthew David Mascarenas (Lakeside, California)
ABSTRACT A multi-mode approach for real-time inspection of structural components may be applied to rapid, wide area measurement of thickness of thick plate-like structures using full-field multi-mode response measurement and analysis. The approach may allow estimation of thickness from full-field multi-mode response to single-tone ultrasonic excitation in thick plates. The approach may utilize wavenumber information across all available wave modes in order to make wavenumber spectroscopy sensitive to changes in thickness for a broader range of nominal initial thicknesses.
FILED Thursday, December 13, 2018
APPL NO 16/219581
ART UNIT 2877 — Optics
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 9/02084 (20130101)
G01B 11/0666 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022542 Green et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency Energy (ARPAE)
APPLICANT(S) INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York);  TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
ASSIGNEE(S) INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
INVENTOR(S) William Green (Yorktown Heights, New York);  Chu Cheyenne Teng (Princeton, New Jersey);  Gerard Wysocki (Princeton, New Jersey);  Eric Zhang (Yorktown Heights, New York)
ABSTRACT An on-chip spectroscopic sensor includes a tunable diode laser. A laser driver for drives the tunable diode laser. An analyte test cavity receives a chemical sample and exposes the received chemical sample to light from the tunable diode laser. An optical detector detects light emerging from the analyte test cavity as a result of the laser exposure. A spectral analyzer determines a spectrum of the emerging light, matches and removes one or more known optical fringe patterns from the determined spectrum, and determines a composition or concentration of the chemical sample from the optical fringe pattern-removed spectrum.
FILED Friday, July 05, 2019
APPL NO 16/504100
ART UNIT 2886 — Optics
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 3/28 (20130101)
G01J 3/42 (20130101)
G01J 3/45 (20130101)
G01J 2003/423 (20130101)
G01J 2003/2869 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/27 (20130101) Original (OR) Class
G01N 21/39 (20130101)
G01N 21/274 (20130101)
G01N 33/0047 (20130101)
G01N 2021/399 (20130101)
G01N 2201/1211 (20130101)
G01N 2201/06113 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022582 Ely
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
Sandia National Laboratories (SNL)
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S) George Ray Ely (Albuquerque, New Mexico)
ABSTRACT A structure includes a substrate and a coating applied over the substrate, the coating containing particles sized between 30 and 250 micrometers. A proportion of the particles to the carrier is between 40 and 70 by volume percentage. In response to excitation of the structure by a controllable excitation source, a first instrument monitors behavior of the particles to determine a first condition of the structure thereby. In response to an absence of excitation of the structure by the controllable excitation source, a second instrument monitors behavior of the particles to determine a second condition of the structure thereby.
FILED Tuesday, August 15, 2017
APPL NO 15/677441
ART UNIT 2863 — Printing/Measuring and Testing
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 25/20 (20130101)
G01N 29/043 (20130101) Original (OR) Class
G01N 29/045 (20130101)
G01N 2291/0231 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022593 Boggess et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC (Aiken, South Carolina)
ASSIGNEE(S) Savannah River Nuclear Solutions, LLC (Aiken, South Carolina)
INVENTOR(S) Andrew J. Boggess (Aiken, South Carolina);  Stephen L. Crump (Martinez, Georgia);  Thomas L. White (Evans, Georgia)
ABSTRACT Sampling devices for sampling an aqueous source (e.g., field testing of ground water) for multiple different analytes are described. Devices include a solid phase extraction component for retention of a wide variety of targeted analytes. Devices include analyte derivatization capability for improved extraction of targeted analytes. Thus, a single device can be utilized to examine a sample source for a wide variety of analytes. Devices also include an isotope dilution capability that can prevent error introduction to the sample analysis and can correct for sample loss and degradation from the point of sampling until analysis as well as correction for incomplete or poor derivatization reactions. The devices can be field-deployable and rechargeable.
FILED Thursday, October 25, 2018
APPL NO 16/170185
ART UNIT 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/10 (20130101)
G01N 1/405 (20130101)
G01N 33/1826 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022717 Ohanian, III et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOEOS)
APPLICANT(S) Luna Innovations Incorporated (Roanoke, Virginia)
ASSIGNEE(S) Luna Innovations Incorporated (Roanoke, Virginia);  Tennessee Technological University (Cookeville, Tennessee)
INVENTOR(S) Osgar John Ohanian, III (Blacksburg, Virginia);  Daniel R. Vandenberge (Cookeville, Tennessee);  Matthew Anthony Davis (Christiansburg, Virginia)
ABSTRACT A system for performing distributed measurements of in-situ stress includes an expandable element with at least one fiber optic sensor. The expandable element can be positioned at various depths in a hole in a substrate. A pressurizing device expands (and contracts) the expandable element when the expandable element is inserted in the hole in the substrate to exert pressure on the hole wall. A pressure sensor provides a sensor output indicative of a pressure applied to the hole wall by the expandable element. The fiber optic sensor and an optical interrogator measure strain along a length of the sensor in a continuous, high spatial resolution manner Based on the measured strain and pressure sensor output, the system determines various properties of the substrate such as, minimum principal stress, maximum principal stress, and/or principal stress direction associated with one or more fractures in the substrate, as well as substrate modulus.
FILED Tuesday, August 28, 2018
APPL NO 16/114376
ART UNIT 2886 — Optics
CURRENT CPC
Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 47/06 (20130101)
E21B 47/135 (20200501)
E21B 49/006 (20130101)

Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure
G01L 1/243 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/47 (20130101)
G01N 2021/4735 (20130101)

Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags
G01V 8/16 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022981 Borhan
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency Energy (ARPAE)
APPLICANT(S) Cummins Inc. (Columbus, Indiana)
ASSIGNEE(S) Cummins Inc. (Columbus, Indiana)
INVENTOR(S) Hoseinali Borhan (Bloomington, Indiana)
ABSTRACT There is disclosed a cloud computing control system for vehicle speed control and also for control of a vehicle in a platoon. The cloud computing control system determines a speed trajectory and neutral coasting command for a first vehicle of the platoon and a vehicle controller determines a reference speed for the first vehicle in response to the speed trajectory and the neutral coasting command, and is response to one or more vehicle specific factors associated with the first vehicle.
FILED Wednesday, October 31, 2018
APPL NO 16/176947
ART UNIT 3649 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit
B60W 30/143 (20130101)
B60W 2552/00 (20200201)
B60W 2555/20 (20200201)
B60W 2555/60 (20200201)

Systems for Controlling or Regulating Non-electric Variables
G05D 1/0027 (20130101)
G05D 1/0088 (20130101)
G05D 1/0221 (20130101)
G05D 1/0223 (20130101) Original (OR) Class

Traffic Control Systems
G08G 1/22 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023242 Kalamatianos et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
APPLICANT(S) Advanced Micro Devices, Inc. (Sunnyvale, California);  ATI Technologies ULC (Markham, Canada)
ASSIGNEE(S) ATI TECHNOLOGIES ULC (Markham, Canada);  ADVANCED MICRO DEVICES, INC. (Sunnyvale, California)
INVENTOR(S) John Kalamatianos (Boxborough, Massachusetts);  Greg Sadowski (Boxborough, Massachusetts);  Syed Zohaib M. Gilani (Markham, Canada)
ABSTRACT A method and apparatus of asynchronous scheduling in a graphics device includes sending one or more instructions from an instruction scheduler to one or more instruction first-in/first-out (FIFO) devices. An instruction in the one or more FIFO devices is selected for execution by a single-instruction/multiple-data (SIMD) pipeline unit. It is determined whether all operands for the selected instruction are available for execution of the instruction, and if all the operands are available, the selected instruction is executed on the SIMD pipeline unit. The self-timed arithmetic pipeline unit (SIMD pipeline unit) is effectively encapsulated in a synchronous, (e.g., clocked by global clock), scheduler and register file environment.
FILED Friday, January 27, 2017
APPL NO 15/417555
ART UNIT 2183 — Computer Architecture and I/O
CURRENT CPC
Electric Digital Data Processing
G06F 9/383 (20130101)
G06F 9/384 (20130101)
G06F 9/3001 (20130101)
G06F 9/3824 (20130101)
G06F 9/3836 (20130101) Original (OR) Class
G06F 9/3851 (20130101)
G06F 9/3871 (20130101)
G06F 9/3877 (20130101)
G06F 9/3887 (20130101)
G06F 9/30036 (20130101)
G06F 12/0875 (20130101)
G06F 15/8007 (20130101)
G06F 2212/452 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023291 Jacob et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S) International Business Machines Corporation (Armonk, New York)
INVENTOR(S) Philip Jacob (Congers, New York);  Philip N. Strenski (Yorktown Heights, New York);  Charles Johns (Austin, Texas)
ABSTRACT A system and method of supporting point-to-point synchronization among processes/nodes implementing different hardware barriers in a tuple space/coordinated namespace (CNS) extended memory storage architecture. The system-wide CNS provides an efficient means for storing data, communications, and coordination within applications and workflows implementing barriers in a multi-tier, multi-nodal tree hierarchy. The system provides a hardware accelerated mechanism to support barriers between the participating processes. Also architected is a tree structure for a barrier processing method where processes are mapped to nodes of a tree, e.g., a tree of degree k to provide an efficient way of scaling the number of processes in a tuple space/coordination namespace.
FILED Friday, May 10, 2019
APPL NO 16/409377
ART UNIT 2196 — Interprocess Communication and Software Development
CURRENT CPC
Electric Digital Data Processing
G06F 9/522 (20130101) Original (OR) Class
G06F 9/546 (20130101)
G06F 9/5072 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023410 Roberts et al.
FUNDED BY
Department of Energy (DOE)
Exascale Computing Project (ECP)
PathForward Project (PATHFORWARD)
Lawrence Livermore National Laboratory (LLNL)
APPLICANT(S) Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S) ADVANCED MICRO DEVICES, INC. (Santa Clara, California)
INVENTOR(S) David A. Roberts (Wellesley, Massachusetts);  Shenghsun Cho (Stonybrook, New York)
ABSTRACT A system is described that performs memory access operations. The system includes a processor in a first node, a memory in a second node, a communication interconnect coupled to the processor and the memory, and an interconnect controller in the first node coupled between the processor and the communication interconnect. Upon executing a multi-line memory access instruction, the processor prepares a memory access operation for accessing, in the memory, a block of data including at least some of each of at least two lines of data. The processor then causes the interconnect controller to use a single remote direct memory access memory transfer to perform the memory access operation for the block of data via the communication interconnect.
FILED Tuesday, September 11, 2018
APPL NO 16/127607
ART UNIT 2184 — Computer Architecture and I/O
CURRENT CPC
Electric Digital Data Processing
G06F 12/0862 (20130101)
G06F 13/1673 (20130101)
G06F 13/4027 (20130101)
G06F 15/17331 (20130101) Original (OR) Class
G06F 2212/1021 (20130101)
G06F 2212/1024 (20130101)
G06F 2212/6026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023579 Wheeler et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
Sandia National Laboratories (SNL)
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
INVENTOR(S) Jason W. Wheeler (Albuquerque, New Mexico);  Tu-Thach Quach (Albuquerque, New Mexico);  Conrad D. James (Albuquerque, New Mexico);  James Bradley Aimone (Albuquerque, New Mexico);  Arun F. Rodrigues (Albuquerque, New Mexico)
ABSTRACT A method and apparatus for monitoring a volatile memory in a computer system. Samples of compressed data from locations in the volatile memory in the computer system are read. Data in the volatile memory is reconstructed using the samples of compressed data. The data is an image of the volatile memory. The image enables determining whether an undesired process is present in the volatile memory.
FILED Thursday, December 01, 2016
APPL NO 15/367026
ART UNIT 2436 — Cryptography and Security
CURRENT CPC
Electric Digital Data Processing
G06F 21/562 (20130101) Original (OR) Class
G06F 21/564 (20130101)
G06F 2212/401 (20130101)
G06F 2212/1052 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 63/145 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024433 Snuggerud
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) NuScale Power, LLC (Corvallis, Oregon)
ASSIGNEE(S) NuScale Power, LLC (Corvallis, Oregon)
INVENTOR(S) Ross Douglas Snuggerud (Corvallis, Oregon)
ABSTRACT A damping area or “dash pot” on the upper ends of control rods absorb energy from dropped control rod assemblies without narrowing the diameter of guide tubes. As a result, coolant can freely flow through the guide tubes reducing boiling water issues. The dampening area reduces a separation distance between an outside surface of the control rod and an inside surface of the guide tubes decelerating the control rods when entering a top end of the guide tubes. In another example, the dampening area may be located on a drive shaft. The dampening area may have a larger diameter than an opening in a drive shaft support member that decelerates the drive shaft when dropped by a drive mechanism.
FILED Friday, December 29, 2017
APPL NO 15/858073
ART UNIT 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review
CURRENT CPC
Nuclear Reactors
G21C 3/322 (20130101)
G21C 3/3315 (20130101)
G21C 7/11 (20130101)
G21C 7/20 (20130101) Original (OR) Class
G21C 7/117 (20130101)
G21C 9/02 (20130101)

Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution
Y02E 30/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024465 Zhu et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
INVENTOR(S) Kai Zhu (Littleton, Colorado);  Donghoe Kim (Seoul, South Korea)
ABSTRACT An aspect of the present disclosure is a perovskite that includes A(n−1−nw+w)A′(wn−w)A″2BnX(3n−3zn+3z−4e+1)X′(3zn−3z)X″4e, where each of A, A′, A″ are monovalent cations, B is a divalent cation, each of X, X′, and X″ are monovalent anions, 0<w≤1, 0<z≤1, 0<e≤1, and 1≤n≤100000.
FILED Monday, September 16, 2019
APPL NO 16/571344
ART UNIT 1622 — Organic Chemistry
CURRENT CPC
Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 1/00 (20130101)
C07F 7/24 (20130101)

Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 9/0036 (20130101)
H01G 9/2009 (20130101) Original (OR) Class
H01G 9/2072 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 27/302 (20130101)
H01L 31/0322 (20130101)
H01L 51/0007 (20130101)
H01L 51/0077 (20130101)
H01L 51/4253 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024734 Conway et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S) Adam Conway (Livermore, California);  Sara Elizabeth Harrison (Fremont, California);  Rebecca J. Nikolic (Oakland, California);  Qinghui Shao (Fremont, California);  Lars Voss (Livermore, California)
ABSTRACT In one embodiment, a method of forming a vertical transistor includes forming a layer comprising a semiconductor material above a substrate, defining three dimensional (3D) structures in the layer, forming a second region in at least one vertical sidewall of each 3D structure, and forming an isolation region between the 3D structures. In another embodiment, an apparatus includes at least one vertical transistor, where the at least one vertical transistor includes: a substrate comprising a semiconductor material, an array of 3D structures above the substrate, and an isolation region positioned between the 3D structures. Each 3D structure includes the semiconductor material. Each 3D structure also includes a first region having a first conductivity type and a second region having a second conductivity type, the second region including a portion of at least one vertical sidewall of the 3D structure.
FILED Wednesday, January 04, 2017
APPL NO 15/398652
ART UNIT 2818 — Semiconductors/Memory
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 29/205 (20130101)
H01L 29/0657 (20130101)
H01L 29/2003 (20130101)
H01L 29/7788 (20130101)
H01L 29/7789 (20130101)
H01L 29/7827 (20130101) Original (OR) Class
H01L 29/8083 (20130101)
H01L 29/66924 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11025025 Walton et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (Livermore, California)
INVENTOR(S) Christopher C. Walton (Oakland, California);  S. Mark Ammons (Oakland, California);  Brian Bauman (Livermore, California);  Robert C. Bickel (Walnut Creek, California);  Willem H. De Vries (Livermore, California);  Alexander Pertica (Livermore, California);  Michael Pivovaroff (Oakland, California);  Vincent Riot (Oakland, California)
ABSTRACT An optical laser beam director assembly is disclosed. The beam director assembly includes a monolithic optics piece formed of transparent optical material, a laser source is coupled to the monolithic optics piece to provide a laser beam to the optics piece, and a beam steerer connected to the optics piece to direct the laser beam output from the optics piece onto a target.
FILED Tuesday, November 27, 2018
APPL NO 16/202015
ART UNIT 2872 — Optics
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 5/08 (20130101)
G02B 27/30 (20130101)
G02B 27/0977 (20130101)

Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor
G03B 21/16 (20130101)

Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 3/0071 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11026326 Takken et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S) International Business Machines Corporation (Armonk, New York)
INVENTOR(S) Todd E. Takken (Brewster, New York);  Xin Zhang (Yorktown Heights, New York);  Yuan Yao (Tarrytown, New York);  Andrew Ferencz (Southborough, Massachusetts)
ABSTRACT A printed circuit board (PCB) structure and mounting assembly for joining two PCBs. A first PCB has a top and bottom surface faces and a peripheral end face separating the top and bottom surface. The first PCB has one or more conductive wire ends exposed at a surface of the peripheral end face; the exposed conductive wire ends forming multiple separate electrical contacts across the thickness and length of the PEF surface. A second PCB has a top surface face and one or more conductive pads exposed at the top surface at locations corresponding to locations of the multiple electrical contacts. A surface mount solder material is disposed on one or more exposed conductive pads for electrically connecting with corresponding the multiple electrical contacts. The disposed solder material stably joins the PEF surface of the first PCB to the top surface of the second PCB in a relative perpendicular orientation.
FILED Thursday, August 01, 2019
APPL NO 16/528908
ART UNIT 2848 — Electrical Circuits and Systems
CURRENT CPC
Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/117 (20130101)
H05K 1/0298 (20130101) Original (OR) Class
H05K 3/366 (20130101)
H05K 3/403 (20130101)
H05K 13/04 (20130101)
H05K 2201/0919 (20130101)
H05K 2201/09145 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11026354 Ledezma et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) TECO-Westinghouse Motor Company (Round Rock, Texas)
ASSIGNEE(S) TECO-Westinghouse Motor Company (Round Rock, Texas)
INVENTOR(S) Enrique Ledezma (Austin, Texas);  Bhaskara Palle (Round Rock, Texas);  Rose Metzler (Cedar Park, Texas)
ABSTRACT In one aspect, a medium voltage power converter includes a cabinet having: a power cube bay to house a plurality of power cubes, each of the plurality of power cubes adapted within a corresponding enclosure and comprising a low frequency front end stage, a DC link and a high frequency back end stage, the plurality of power cubes to couple to a high speed machine; and a plurality of first barriers adapted to isolate and direct a first flow of cooling air through one of the plurality of power cubes; and a transformer bay having at least one transformer to couple between a utility connection and the plurality of power cubes, the transformer bay including a plurality of cooling fans to cool the at least one transformer.
FILED Monday, December 16, 2019
APPL NO 16/715013
ART UNIT 2835 — Electrical Circuits and Systems
CURRENT CPC
Boards, Substations, or Switching Arrangements for the Supply or Distribution of Electric Power
H02B 1/565 (20130101)

Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof
H02M 5/4585 (20130101)
H02M 7/003 (20130101)

Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils
H02P 27/08 (20130101)

Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 7/202 (20130101)
H05K 7/20154 (20130101)
H05K 7/20254 (20130101)
H05K 7/20572 (20130101)
H05K 7/20609 (20130101)
H05K 7/20927 (20130101) Original (OR) Class
H05K 7/20936 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 11020001 Melodia et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Northeastern University (Boston, Massachusetts)
ASSIGNEE(S) Northeastern University (Boston, Massachusetts)
INVENTOR(S) Tommaso Melodia (Newton, Massachusetts);  Giuseppe Enrico Santagati (Cambridge, Massachusetts)
ABSTRACT An ultrasonic communication system and method provide a networking framework for wearable devices based on ultrasonic communications. The ultrasonic communication system and method incorporate a set of physical, data link, network and application layer functionalities that can flexibly adapt to application and system requirements to efficiently distribute information between ultrasonic wearable devices.
FILED Thursday, April 11, 2019
APPL NO 16/381716
ART UNIT 2687 — Dynamic Storage Systems; Mechanical parts of Disk Drives
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0015 (20130101) Original (OR) Class
A61B 5/0024 (20130101)
A61B 5/0026 (20130101)
A61B 5/0028 (20130101)
A61B 5/0205 (20130101)
A61B 5/02438 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 40/63 (20180101)

Transmission
H04B 11/00 (20130101)

Wireless Communication Networks
H04W 84/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020046 Lee et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Hanmin Lee (San Francisco, California);  Sachin Rangarajan (San Francisco, California);  Isabelle Chumfong (San Francisco, California)
ABSTRACT Provided herein are methods and systems for monitoring a patient using a pressure-sensing device containing a pressure-sensitive region configured to selectively overlie a pressure ulcer-prone body part of the patient. In some embodiments, the pressure-sensing device includes a multilayered sensing unit containing a pressure-sensing layer to sense force and an adhesive layer configured to attach the pressure-sensing device to the body part. Also provided is a kit that includes the pressure-sensing device. The present methods, systems, and kits may find use in reducing the risk of pressure ulcer development in a patient.
FILED Thursday, January 12, 2017
APPL NO 16/068847
ART UNIT 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0004 (20130101)
A61B 5/0022 (20130101)
A61B 5/447 (20130101) Original (OR) Class
A61B 5/742 (20130101)
A61B 5/746 (20130101)
A61B 5/1115 (20130101)
A61B 5/4848 (20130101)
A61B 5/6833 (20130101)
A61B 5/6892 (20130101)
A61B 5/7225 (20130101)
A61B 5/7242 (20130101)
A61B 5/7275 (20130101)
A61B 5/7405 (20130101)
A61B 5/7455 (20130101)
A61B 2562/046 (20130101)
A61B 2562/0247 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 50/20 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020491 Lowe et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S) RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey)
INVENTOR(S) Christopher Lowe (Piscataway, New Jersey);  David I. Shreiber (Whitehouse Station, New Jersey);  Emily DiMartini (Piscataway, New Jersey);  Adam Gormley (New Brunswick, New Jersey)
ABSTRACT The present invention provides a biocompatible conjugate for treating a disease or an injury. The conjugate contains a polymer covalently linked to one or more moieties each containing a polymerizable functional group. The conjugate forms a cross-linked polymer network after being exposed to an elevated level of free radicals associated with the disease or injury.
FILED Thursday, June 14, 2018
APPL NO 16/009033
ART UNIT 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/10 (20130101)
A61K 47/32 (20130101)
A61K 47/34 (20130101)
A61K 47/6935 (20170801) Original (OR) Class

Compositions of Macromolecular Compounds
C08L 33/06 (20130101)
C08L 33/20 (20130101)
C08L 33/26 (20130101)
C08L 2203/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020497 Steinmetz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
INVENTOR(S) Nicole Steinmetz (San Diego, California);  Michael Bruckman (Cleveland, Ohio)
ABSTRACT A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
FILED Tuesday, October 02, 2018
APPL NO 16/149828
ART UNIT 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/1884 (20130101)
A61K 49/1896 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 2770/00031 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020731 Goldman et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey)
ASSIGNEE(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
INVENTOR(S) Alan S. Goldman (Piscataway, New Jersey);  Yang Gao (Piscataway, New Jersey)
ABSTRACT The present invention relates in part to the unexpected discovery of novel complexes capable of catalyzing the selective dehydrogenative coupling of olefins. The invention further relates to the use of these complexes for the selective coupling of olefins.
FILED Tuesday, October 30, 2018
APPL NO 16/175339
ART UNIT 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 31/182 (20130101)
B01J 31/2295 (20130101) Original (OR) Class
B01J 2231/46 (20130101)
B01J 2231/4205 (20130101)
B01J 2531/0244 (20130101)
B01J 2531/827 (20130101)
B01J 2540/10 (20130101)

Acyclic or Carbocyclic Compounds
C07C 2/76 (20130101)
C07C 2/76 (20130101)
C07C 2/86 (20130101)
C07C 11/167 (20130101)
C07C 2531/22 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11020736 Abate et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Navy (DON)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Adam R. Abate (San Francisco, California);  Adam R. Sciambi (San Francisco, California);  Russell Cole (San Francisco, California);  Zev Jordan Gartner (Pacifica, California)
ABSTRACT Methods for delivering discrete entities including, e.g., cells, media or reagents to substrates are provided. In certain aspects, the methods include manipulating and/or analyzing qualities of the entities or biological components thereof. In some embodiments, the methods may be used to create arrays of microenvironments and/or for two and three-dimensional printing of tissues or structures. Systems and devices for practicing the subject methods are also provided.
FILED Tuesday, August 27, 2019
APPL NO 16/552982
ART UNIT 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/0268 (20130101) Original (OR) Class
B01L 3/502784 (20130101)
B01L 2200/0673 (20130101)
B01L 2300/0645 (20130101)
B01L 2300/0829 (20130101)
B01L 2300/0864 (20130101)
B01L 2400/086 (20130101)
B01L 2400/0427 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/1459 (20130101)
G01N 15/1463 (20130101)
G01N 15/1484 (20130101)
G01N 2015/149 (20130101)
G01N 2015/1006 (20130101)
G01N 2035/1034 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021447 Lohrman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Oregon (Eugene, Oregon);  University of Montana (Missoula, Montana)
ASSIGNEE(S) University of Oregon (Eugene, Oregon);  University of Montana (Missoula, Montana)
INVENTOR(S) Jessica Lohrman (Eugene, Oregon);  Darren W. Johnson (Eugene, Oregon);  Michael M. Haley (Eugene, Oregon);  Orion B. Berryman (Missoula, Montana);  Asia M. Riel (Missoula, Montana);  Daniel A. Decato (Missoula, Montana)
ABSTRACT A compound, or a protonate or salt thereof, of formula I:
    • wherein Y is aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
    • n is 1 or 2;
    • each R10 is independently alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, aryl, substituted aryl, cyano, hydroxyl, carbonylamino, aminocarbonyl, acyl, sulfonyl, or substituted sulfonyl;
    • a is 0 to 4;

is an aryl or heteroaryl ring; and
    • each R is independently halogen, carbonylamino, sulfonamide, carboxylic acid or hydrogen, provided at least one R is a halogen; and
    • provided that if Y is

are not
respectively.
FILED Wednesday, May 01, 2019
APPL NO 16/401037
ART UNIT 1625 — Organic Chemistry
CURRENT CPC
Heterocyclic Compounds
C07D 213/22 (20130101)
C07D 213/90 (20130101)
C07D 233/56 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6428 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021489 Haley et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Oregon (Eugene, Oregon)
ASSIGNEE(S) University of Oregon (Eugene, Oregon)
INVENTOR(S) Michael Haley (Eugene, Oregon);  Justin Dressler (Eugene, Oregon);  Joshua Barker (Eugene, Oregon)
ABSTRACT Disclosed herein are polycyclic aromatic compound embodiments and methods of making and using such compounds. In some embodiments, the polycyclic aromatic compounds comprise an indenoindenodi(benzothiophene) skeleton. The polycyclic aromatic compound embodiments can be used in a variety of devices, such as electronic and/or electrooptical devices.
FILED Friday, February 28, 2020
APPL NO 16/805382
ART UNIT 1625 — Organic Chemistry
CURRENT CPC
Heterocyclic Compounds
C07D 487/04 (20130101)
C07D 493/04 (20130101)
C07D 495/04 (20130101) Original (OR) Class

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/0072 (20130101)
H01L 51/0073 (20130101)
H01L 51/0074 (20130101)
H01L 51/0094 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021516 Ulijn et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
U.S. Air Force
Department of Energy (DOE)
UChicago Argonne, LLC (UCHICAGO)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
Division of Materials Research (DMR)
APPLICANT(S) Research Foundation of the City University of New York (New York, New York);  University of Strathclyde (Glasgow, United Kingdom);  Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S) Research Foundation of the City University of New York (New York, New York);  University of Strathclyde (Glasgow, United Kingdom);  Carnegie Mellon University (Pittsburgh, Pennsylvania)
INVENTOR(S) Rein V. Ulijn (New York, New York);  Ayala Lampel (Bronx, New York);  Tell Tuttle (Glasgow, United Kingdom);  Gary Scott (Glasgow, United Kingdom);  Scott McPhee (New York, New York);  Christopher Bettinger (Pittsburgh, Pennsylvania)
ABSTRACT A self-assembling peptide is provided that is enzymatically oxidized to form a polymeric pigment. The monomeric peptide has three amino acids (tyrosine (Y), one phenylalanine (F), and one aspartic acid (D) or one lysine (K)) and, following self-assembly and treatment with a tyrosinase enzyme oxidizes and polymerizes into a material with predetermined properties.
FILED Monday, September 11, 2017
APPL NO 16/332231
ART UNIT 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)

Peptides
C07K 5/0812 (20130101) Original (OR) Class
C07K 5/0819 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 69/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021554 Carrow et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
ASSIGNEE(S) THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey)
INVENTOR(S) Brad P Carrow (Princeton, New Jersey);  Wei Zhang (Exton, Pennsylvania)
ABSTRACT In one aspect, a chelating phosphine-phosphonic diamide (PPDA) ligand is described herein for constructing transition metal complexes operable for catalysis of olefin polymerization, including copolymerization of ethylene with polar monomer.
FILED Wednesday, April 17, 2019
APPL NO 16/387100
ART UNIT 1765 — Organic Chemistry, Polymers, Compositions
CURRENT CPC
Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 9/28 (20130101)
C07F 9/44 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 4/80 (20130101)
C08F 4/7014 (20130101)
C08F 4/7014 (20130101)
C08F 10/02 (20130101)
C08F 110/02 (20130101)
C08F 210/02 (20130101) Original (OR) Class
C08F 210/02 (20130101)
C08F 210/02 (20130101)
C08F 210/02 (20130101)
C08F 210/02 (20130101)
C08F 210/02 (20130101)
C08F 216/12 (20130101)
C08F 216/18 (20130101)
C08F 218/12 (20130101)
C08F 220/00 (20130101)
C08F 220/02 (20130101)
C08F 220/06 (20130101)
C08F 220/06 (20130101)
C08F 220/10 (20130101)
C08F 220/14 (20130101)
C08F 220/14 (20130101)
C08F 220/44 (20130101)
C08F 2410/01 (20130101)
C08F 2500/02 (20130101)
C08F 2500/02 (20130101)
C08F 2500/02 (20130101)
C08F 2500/02 (20130101)
C08F 2500/02 (20130101)
C08F 2500/03 (20130101)
C08F 2500/03 (20130101)
C08F 2500/03 (20130101)
C08F 2500/03 (20130101)
C08F 2500/03 (20130101)
C08F 2500/10 (20130101)
C08F 2500/10 (20130101)
C08F 2500/10 (20130101)
C08F 2500/10 (20130101)
C08F 2500/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021723 Coleman et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Todd Prentice Coleman (La Jolla, California);  Marianne Catanho (San Diego, California);  Phillip Kyriakakis (San Diego, California)
ABSTRACT Methods, systems, and devices are disclosed for in vivo production or biosynthesis of metabolites in foreign cells using the combination of (i) one or more ferredoxin dependent enzyme(s) and (ii) a ferredoxin (Fd)/ferredoxin-NADP+ reductase (FNR) system. The ferredoxin dependent enzymes and the Fd/FNR system are from the same species or from a different but matching species.
FILED Thursday, May 04, 2017
APPL NO 16/098700
ART UNIT 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Peptides
C07K 5/0215 (20130101)
C07K 14/4702 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/001 (20130101)
C12N 9/0095 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 3/00 (20130101)
C12P 13/14 (20130101)
C12P 17/165 (20130101) Original (OR) Class

Enzymes
C12Y 103/07004 (20130101)
C12Y 103/07005 (20130101)
C12Y 118/01002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021724 Stewart et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) University of Florida Research Foundation, Inc. (Gainesville, Florida);  AgroParisTech (Paris, France)
ASSIGNEE(S) University of Florida Research Foundation, Inc. (Gainsville, Florida);  AfroParisTech (Paris, France)
INVENTOR(S) Jon Dale Stewart (Orlando, Florida);  Florent Allais (Bouy, France);  Louis Michel Marie Mouterde (Reims, France)
ABSTRACT The subject invention concerns materials and methods for alkene reduction of compounds, such as levoglucosenone (LGO) and (S)-γ-hydroxymethyl-α,β-butenolide (HBO), using an alkene reductase enzyme. In one embodiment, a method of the invention comprises alkene reduction of a target compound by reacting the compound with an Old Yellow Enzyme (OYE) that reduces alkene bonds. In one embodiment, the OYE is OYE 2.6 from Pichia stipites and comprises the amino acid sequence of SEQ ID NO: I. In a specific embodiment, the enzyme is an Old Yellow Enzyme (OYE) 2.6 mutant having an amino acid substitution at position 78 in the sequence, wherein the tyrosine at position 78 is substituted with a tryptophan amino acid (Y78W) and is designated as OYE 2.6 Y78W (SEQ ID NO:2).
FILED Thursday, March 29, 2018
APPL NO 16/490556
ART UNIT 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes
CURRENT CPC
Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 17/181 (20130101) Original (OR) Class

Enzymes
C12Y 106/99001 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022115 Vacca et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Andrea Vacca (Lafayette, Indiana);  Srinath Tankasala (Boston, Massachusetts)
ABSTRACT A controlled variable delivery external gear machine (VD-EGM). The VD-EGM includes a housing, an inlet, a drive gear, a driven gear, the drive gear configured to engage the driven gear in an angular mesh zone, an outlet, a first slider comprising a first longitudinal portion connected to a second longitudinal portion such that longitudinal forces applied to the first and second longitudinal portions substantially cancel each other thereby requiring between about 0 N to about 20 N to longitudinally moving the first slider, selective positioning of the first slider configured to vary net operational volumes of fluid communication between the inlet and the outlet, for a given rotational speed of the drive gear, and a first drive mechanism coupled to the first slider and configured to cause the first slider to slide in a longitudinal direction.
FILED Wednesday, May 30, 2018
APPL NO 15/993505
ART UNIT 3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps
F04C 2/18 (20130101)
F04C 14/18 (20130101) Original (OR) Class
F04C 2240/811 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022500 Yuan et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
INVENTOR(S) Baohong Yuan (Arlington, Texas);  Shuai Yu (Mansfield, Texas);  Tingfeng Yao (Arlington, Texas)
ABSTRACT In one aspect, methods of measuring the temperature of an environment are described herein. In some embodiments, such a method comprises (a) disposing a population of ultrasound-switchable fluorophores in the environment, the population comprising n differing fluorophores having n differing switching threshold temperatures; (b) exposing the environment to an ultrasound beam to create an activation region having a temperature greater than or equal to one or more of the switching threshold temperatures; (c) disposing the fluorophores within the activation region to switch at least one fluorophore from an off state to an on state; (d) exposing the environment to up to n beams of electromagnetic radiation, thereby exciting at least one fluorophore in the on state; (e) detecting up to n photoluminescence signals emitted by the fluorophores; and (f) correlating the photoluminescence signals with up to n temperatures or temperature ranges.
FILED Friday, June 02, 2017
APPL NO 16/304408
ART UNIT 2855 — Printing/Measuring and Testing
CURRENT CPC
Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for
G01K 11/20 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022501 Hsieh et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Feasible, Inc. (Berkeley, California)
ASSIGNEE(S) Feasible, Inc. (Berkeley, California)
INVENTOR(S) Andrew Gaheem Hsieh (Berkeley, California);  Barry James Van Tassell (El Cerrito, California);  Daniel Artemis Steingart (Princeton, New Jersey);  Shaurjo Biswas (El Cerrito, California);  Robert Charles Mohr (Berkeley, California)
ABSTRACT Systems and methods for measuring temperature characteristics of a battery include one or more transducers coupled to the battery for transmitting and/or receiving sound waves through at least a portion of the battery. A temperature measurement unit is provided to determine a time-of-flight of sound waves through at least the portion of the battery based on transmitted and received sound waves through at least the portion of the battery, and to determine temperature characteristics of at least the portion of the battery based on the time-of-flight.
FILED Friday, October 11, 2019
APPL NO 16/599562
ART UNIT 2867 — Printing/Measuring and Testing
CURRENT CPC
Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for
G01K 11/24 (20130101) Original (OR) Class

Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/382 (20190101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/486 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022592 Zang et al.
FUNDED BY
Department of Homeland Security (DHS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S) University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S) Ling Zang (Salt Lake City, Utah);  Na Wu (Salt Lake City, Utah);  Paul Slattum (Salt Lake City, Utah)
ABSTRACT A chemiresistive vapor sensor compound for detecting target vapors can comprise a perylene-tetracarboxylic diimide (PTCDI) core according to structure (I):
where R can be a morphology control group or -A′-D′, A and A′ can be independently a linking group, D and D′ can be independently a strong electron donor which transfers electrons to the PTCDI core sufficient to form an anionic PTCDI radical of the PTCDI core, and R1 to R8 can be independently a side group. A chemiresistive vapor sensor for detection of a target compound can comprise an assembly of nanofibers formed of the chemiresistive sensor compound and a pair of electrodes operatively oriented about the assembly of nanofibers to allow electrical current to pass from a first electrode in the pair of electrodes through the assembly of nanofibers and to a second electrode in the pair of electrodes.
FILED Friday, December 02, 2016
APPL NO 15/368276
ART UNIT 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Heterocyclic Compounds
C07D 471/06 (20130101)

Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 5/62 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/04 (20130101)
G01N 27/127 (20130101)
G01N 33/0037 (20130101)
G01N 33/0057 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022610 Dong et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S) Iowa State University Research Foundation, Inc. (Ames, Iowa)
INVENTOR(S) Liang Dong (Ames, Iowa);  Azahar Ali (Ames, Iowa);  Shawana Tabassum (Ames, Iowa);  Qiugu Wang (Ames, Iowa);  Ratnesh Kumar (Ames, Iowa)
ABSTRACT An integrated dual-modality microfluidic sensor chip and methods for using the same. In one form, the sensor comprises a patterned periodic array of nanoposts coated with a noble metal and graphene oxide (GO) to detect target biomarker molecules in a limited sample volume. The device generates both electrochemical and surface plasmon resonance (SPR) signals from a single sensing area of the metal-GO nanoposts. The metal-GO nanoposts are functionalized with specific receptor molecules, serving as a spatially well-defined nanostructured working electrode for electrochemical sensing, as well as a nanostructured plasmonic crystal for SPR-based sensing via the excitation of surface plasmon polaritons. The integrated dual-modality sensor offers higher sensitivity (through higher surface area and diffusions from nanoposts for electrochemical measurements), as well as the dynamic measurements of antigen-antibody bindings (through the SPR measurement), while operating simultaneously in a same sensing area using a same sample volume.
FILED Monday, January 21, 2019
APPL NO 16/253104
ART UNIT 1795 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 2200/027 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/553 (20130101)
G01N 27/3276 (20130101)
G01N 27/3278 (20130101)
G01N 33/531 (20130101)
G01N 33/553 (20130101) Original (OR) Class
G01N 33/5748 (20130101)
G01N 2021/258 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022654 Wang et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) University of Tennessee Research Foundation (Knoxville, Tennessee);  Keysight Technologies, Inc. (Santa Rosa, California)
ASSIGNEE(S) UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee);  KEYSIGHT TECHNOLOGIES, INC. (Santa Rosa, California)
INVENTOR(S) Fei Wang (Knoxville, Tennessee);  Wen Zhang (Wuhan, China PRC);  Bernhard Holzinger (Gaertringen, Germany)
ABSTRACT A system includes a controller that is configured to generate a plurality of switch control signals; a plurality of electrical circuit elements, the plurality of electrical circuit elements being characterized by a plurality of impedances, respectively; a plurality of voltage sources; and a plurality of switches that are programmable to couple the plurality of electrical circuit elements to the plurality of voltage sources responsive to the plurality of switch control signals.
FILED Thursday, March 12, 2020
APPL NO 16/817105
ART UNIT 2849 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/40 (20130101) Original (OR) Class
G01R 31/2621 (20130101)
G01R 31/2623 (20130101)
G01R 31/2879 (20130101)
G01R 31/31721 (20130101)
G01R 31/31723 (20130101)
G01R 31/31924 (20130101)
G01R 31/31926 (20130101)

Electric Digital Data Processing
G06F 11/2733 (20130101)

Pulse Technique
H03K 17/693 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023523 Hauptmann et al.
FUNDED BY
Department of Homeland Security (DHS)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) Alexander G. Hauptmann (Finleyville, Pennsylvania)
ASSIGNEE(S) Carnegie Mellon University (Pittsburgh, Pennsylvania)
INVENTOR(S) Alexander G. Hauptmann (Finleyville, Pennsylvania);  Lu Jiang (Pittsburgh, Pennsylvania);  Po-yao Huang (Pittsburgh, Pennsylvania)
ABSTRACT This document describes a search retrieval system for automatically indexing data representing audio-visual recordings and for querying, responsive to a search query, that indexed data representing the audio-visual recordings. The search retrieval system defines weights for semantic features of an audio-visual recording and extracts, based on execution of a first set of rules, one or more semantic features. The system determines a weight for each of the one or more semantic features. A search engine searches nodes in the graph of the semantic features to identify one or more logical relationships for the one or more semantic features extracted. The weights for each of the one or more semantic features are adjusted based on the graph. The data is indexed in association with the one or more adjusted weights for the one or more semantic features, respectively.
FILED Monday, October 24, 2016
APPL NO 15/769233
ART UNIT 2166 — Data Bases & File Management
CURRENT CPC
Electric Digital Data Processing
G06F 16/71 (20190101) Original (OR) Class
G06F 16/78 (20190101)
G06F 16/738 (20190101)
G06F 16/7834 (20190101)
G06F 16/7837 (20190101)
G06F 16/7844 (20190101)

Computer Systems Based on Specific Computational Models
G06N 5/025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023594 Nissim Kobliner et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Georgetown University (Washington, District of Columbia);  President and Fellows of Harvard College (Cambridge, Massachusetts);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S) Georgetown University (Washington, District of Columbia)
INVENTOR(S) Yaacov Nissim Kobliner (Brookline, Massachusetts);  Uri Stemmer (Cambridge, Massachusetts);  Raef Bahi Youssef Bassily (San Diego, California);  Abhradeep Guha Thakurta (Santa Cruz, California)
ABSTRACT Technologies are disclosed for computing heavy hitter histograms using locally private randomization. Under this strategy, “agents” can each hold a “type” derived from a large dictionary. By performing an algorithm, an estimate of the distribution of data can be obtained. Two algorithms implement embodiments for performing methods involving differential privacy for one or more users, and usually are run in the local model. This means that information is collected from the agents with added noise to hide the agents' individual contributions to the histogram. The result is an accurate enough estimate of the histogram for commercial or other applications relating to the data collection of one or more agents. Specifically, the proposed algorithms improve on the performance (measured in computation and memory requirements at the server and the agent, as well as communication volume) of previously solutions.
FILED Tuesday, May 22, 2018
APPL NO 15/986734
ART UNIT 2437 — Cryptography and Security
CURRENT CPC
Electric Digital Data Processing
G06F 21/602 (20130101) Original (OR) Class
G06F 21/6245 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/0643 (20130101)
H04L 2209/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024047 Peng et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Yan-Tsung Peng (New Taipei, Taiwan);  Pamela Cosman (La Jolla, California)
ABSTRACT The invention provides a method for depth estimation in image or video obtained from a distorting medium. In the method, a pixel blurriness map is calculated. A rough depth map is then determined from the pixel blurriness map while assuming depth in a small local patch is uniform. The rough depth map is then refined. The method can be implemented in imaging systems, such as cameras or imaging processing computers, and the distorting medium can be an underwater medium, haze, fog, low lighting, or a sandstorm, for example. Preferred embodiments determined the blurriness map by calculating a difference between an original image and multi-scale Gaussian-filtered images to estimate the pixel blurriness map.
FILED Thursday, September 15, 2016
APPL NO 15/759106
ART UNIT 2664 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation
CURRENT CPC
Image Data Processing or Generation, in General
G06T 5/002 (20130101)
G06T 5/005 (20130101)
G06T 5/20 (20130101)
G06T 7/90 (20170101)
G06T 7/571 (20170101)
G06T 7/586 (20170101) Original (OR) Class
G06T 2207/10016 (20130101)
G06T 2207/10024 (20130101)

Pictorial Communication, e.g Television
H04N 5/2252 (20130101)
H04N 5/23229 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024429 Patek et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Science Foundation (NSF)
APPLICANT(S) Stephen D. Patek (Charlottesville, Virginia);  Boris P. Kovatchev (Charlottesville, Virginia)
ASSIGNEE(S) UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia)
INVENTOR(S) Stephen D. Patek (Charlottesville, Virginia);  Boris P. Kovatchev (Charlottesville, Virginia)
ABSTRACT An Adaptive Advisory Control (AA Control) interactive process involving algorithm-based assessment and communication of physiologic and behavioral parameters and patterns assists patients with diabetes with the optimization of their glycemic control. The method and system may uses all available sources of information about the patient; (i) EO Data (e.g. self-monitoring of blood glucose (SMBG) and CMG), (ii) Insulin Data (e.g. insulin pump log files or patient treatment records), and (iii) Patient Self Reporting Data (e.g. self treatment behaviors, meals, and exercise) to: retroactively assess the risk of hypoglycemia, retroactively assess risk-based reduction of insulin delivery, and then report to the patient how a risk-based insulin reduction system would have acted consistently to prevent hypoglycemia.
FILED Sunday, August 26, 2012
APPL NO 14/241383
ART UNIT 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/002 (20130101)
A61B 5/0022 (20130101)
A61B 5/486 (20130101)
A61B 5/743 (20130101)
A61B 5/1118 (20130101)
A61B 5/4812 (20130101)
A61B 5/4839 (20130101)
A61B 5/4848 (20130101)
A61B 5/4857 (20130101)
A61B 5/4866 (20130101)
A61B 5/7225 (20130101)
A61B 5/7275 (20130101)
A61B 5/7278 (20130101)
A61B 5/7282 (20130101)
A61B 5/7475 (20130101)
A61B 5/14532 (20130101)
A61B 2505/07 (20130101)
A61B 2560/0295 (20130101)
A61B 2560/0475 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/1723 (20130101)
A61M 5/16886 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/17 (20180101)
G16H 20/30 (20180101)
G16H 50/30 (20180101)
G16H 50/50 (20180101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024710 Robinson et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S) The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S) Joshua Alexander Robinson (Spring Mills, Pennsylvania);  Rafael Vila (Sierra Vista, Arizona)
ABSTRACT The present invention relates to methods for fabricating vertical homogenous and heterogeneous two-dimensional structures, the fabricated vertical two-dimensional structures, and methods of using the same. The methods demonstrated herein produce structures that are free standing and electrically isolated.
FILED Friday, September 22, 2017
APPL NO 15/712561
ART UNIT 2895 — Semiconductors/Memory
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/0242 (20130101)
H01L 21/0259 (20130101)
H01L 21/02376 (20130101)
H01L 21/02378 (20130101)
H01L 21/02381 (20130101)
H01L 21/02565 (20130101)
H01L 21/02568 (20130101)
H01L 21/02612 (20130101)
H01L 21/02664 (20130101)
H01L 29/24 (20130101)
H01L 29/045 (20130101)
H01L 29/0665 (20130101) Original (OR) Class
H01L 29/0669 (20130101)
H01L 29/778 (20130101)
H01L 29/785 (20130101)
H01L 29/66795 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024859 Chen et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S) Board of Regents, The University of Texas System (Austin, Texas)
INVENTOR(S) Dongmei Chen (Austin, Texas);  Wei Li (Austin, Texas);  Russell Borduin (Austin, Texas)
ABSTRACT Membranes and methods of making and using the membranes are described herein. The membranes can include a foamed polymeric support and a plurality of inorganic particles disposed within the foamed polymeric support. The foamed polymeric support can contain a hydrophilic polymer such as polyethersulfone. The plurality of inorganic particles can include hydrophilic particles such as zeolite particles. In certain embodiments, the membrane can be used in humidifiers, such as those used in fuel cell systems. In some aspects, the membrane can be used for separating a fluid mixture comprising water. The membranes described herein are stable for high temperature applications.
FILED Friday, February 03, 2017
APPL NO 15/424125
ART UNIT 1773 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus
CURRENT CPC
Separation
B01D 67/0079 (20130101)
B01D 69/148 (20130101)
B01D 71/028 (20130101)
B01D 71/68 (20130101)

Preparation or Pretreatment of the Material to be Shaped; Making Granules or Preforms; Recovery of Plastics or Other Constituents of Waste Material Containing Plastics
B29B 11/10 (20130101)

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 44/3453 (20130101)
B29C 48/08 (20190201)
B29C 67/202 (20130101)

Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts
B29K 2069/00 (20130101)
B29K 2071/00 (20130101)
B29K 2075/00 (20130101)
B29K 2077/00 (20130101)
B29K 2081/06 (20130101)
B29K 2105/16 (20130101)
B29K 2105/041 (20130101)
B29K 2503/04 (20130101)
B29K 2995/0063 (20130101)
B29K 2995/0092 (20130101)

Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles
B29L 2031/755 (20130101)
B29L 2031/3468 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 8/04149 (20130101) Original (OR) Class
H01M 2008/1095 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11025321 Paramesh et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S) CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania)
INVENTOR(S) Jeyanandh Paramesh (Pittsburgh, Pennsylvania);  Susnata Mondal (Pittsburgh, Pennsylvania)
ABSTRACT Designs and techniques to enhance power-efficiency and incorporate new features in millimeter-wave MIMO transceivers are described. A new mechanism for built-in dual-band, per-element self-interference cancellation (SIC) is introduced to enable multi-antenna frequency-division duplex (FDD) and full-duplex (FD) operation. Additionally, several innovative circuit concepts are introduced, including low-loss wideband antenna interface design, dual-band power combining PA, dual-band RF-SIC design, and bi-directional MIMO signal path design.
FILED Monday, February 03, 2020
APPL NO 16/780535
ART UNIT 2632 — Digital Communications
CURRENT CPC
Antennas, i.e Radio Aerials
H01Q 1/523 (20130101)
H01Q 3/38 (20130101)
H01Q 21/0025 (20130101)

Transmission
H04B 1/40 (20130101)
H04B 7/0413 (20130101)
H04B 7/0617 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11025519 Koral et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) AT and T Intellectual Property I, L.P. (Atlanta, Georgia)
ASSIGNEE(S) AT and T Intellectual Property I, L.P. (Atlanta, Georgia);  The Trustees Of Princeton University (Princeton, New Jersey)
INVENTOR(S) Yaron Koral (Cherry Hill, New Jersey);  Tuan Duong (Eatontown, New Jersey);  Steven A. Monetti (Mountain Lakes, New Jersey);  Tzuu-Yi Wang (Newtown, Pennsylvania);  Simon Tse (Holmdel, New Jersey);  Shir Landau Feibish (Princeton, New Jersey);  Jennifer Rexford (Princeton, New Jersey);  Xiaoqi Chen (Princeton, New Jersey)
ABSTRACT Methods, systems, and computer-readable media for measuring packet delays are provided. An input port of a network device is tapped to duplicate an input packet stream having a first packet. An output port of the network device is tapped to duplicate an output packet stream including the first packet. The duplicated input packet stream and the duplicated output packet stream is transmitted to a programmable device. The first packet in the first input packet stream is matched to the first packet in the first output packet stream. An arrival time and a departure time for the first packet is measured. The difference between the departure time of the first packet and the arrival time of the first packet is determined and the value is reported to an external collector.
FILED Wednesday, April 10, 2019
APPL NO 16/380484
ART UNIT 2464 — Multiplex and VoIP
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 43/12 (20130101)
H04L 43/0858 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11025600 Medard et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Muriel Medard (Belmont, Massachusetts);  Prakash Narayana Moorthy (Framingham, Massachusetts);  Vitaly Abdrashitov (Somerville, Massachusetts)
ABSTRACT Methods for encoding a file and de-duplicating a coded packet of the file are presented. The encoding method includes: identifying a file to be stored; encoding the file to generate a plurality of coded packets; generating a hash code associated with the file; distributing the plurality of coded packets to a plurality of storage nodes; and storing the hash code associated with the file in a hash server. The de-duplicating method includes: receiving a coded packet at a storage node; retrieving a hash code, from the hash server, corresponding to the coded packet; determining whether the coded packet has been stored in the storage node based upon the hash code; in response to determination that the coded packet has being stored, discarding the coded packet; and in response to determination that the coded packet has not being stored, storing the coded packet in the storage node.
FILED Thursday, November 08, 2018
APPL NO 16/184272
ART UNIT 2493 — Cryptography and Security
CURRENT CPC
Electric Digital Data Processing
G06F 16/256 (20190101)
G06F 16/1827 (20190101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 41/12 (20130101)
H04L 61/103 (20130101)
H04L 61/2007 (20130101)
H04L 61/6086 (20130101)
H04L 63/0471 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 11019776 Klessig et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Boyce Thompson Institute for Plant Research, Inc. (Ithaca, New York)
ASSIGNEE(S) BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC. (Ithaca, New York)
INVENTOR(S) Daniel Klessig (Dryden, New York);  Frank Schroeder (Ithaca, New York);  Patricia Manosalva (Ithaca, New York)
ABSTRACT Compositions and methods for enhancing disease resistance in plants are disclosed.
FILED Tuesday, October 16, 2018
APPL NO 16/161252
ART UNIT 1663 — Plants
CURRENT CPC
New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques
A01H 3/04 (20130101) Original (OR) Class

Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 43/16 (20130101)
A01N 43/38 (20130101)
A01N 63/10 (20200101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/8281 (20130101)
C12N 15/8282 (20130101)
C12N 15/8283 (20130101)
C12N 15/8285 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11019809 Prather et al.
FUNDED BY
Department of Agriculture (USDA)
Agricultural Research Service (ARS)
APPLICANT(S) The Curators of the University of Missouri (Columbia, Missouri)
ASSIGNEE(S) The Curators of the University of Missouri (Columbia, Missouri)
INVENTOR(S) Randall S. Prather (Rocheport, Missouri);  Kevin D. Wells (Columbia, Missouri);  Kristin M. Whitworth (Columbia, Missouri)
ABSTRACT The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided.
FILED Friday, August 30, 2019
APPL NO 16/556878
ART UNIT 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0276 (20130101) Original (OR) Class
A01K 2217/15 (20130101)
A01K 2217/075 (20130101)
A01K 2227/108 (20130101)
A01K 2267/02 (20130101)

Peptides
C07K 14/7056 (20130101)
C07K 14/70596 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/8509 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021760 Schardl et al.
FUNDED BY
Department of Agriculture (USDA)
Agriculture and Food Research Initiative (AFRI)
National Institute of Food and Agriculture (NIFA)
Agriculture and Food Research Initiative (AFRI)
APPLICANT(S) University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S) University of Kentucky Research Foundation (Lexington, Kentucky)
INVENTOR(S) Christopher L. Schardl (Lexington, Kentucky);  Simona Florea (Lexington, Kentucky);  Mark L. Farman (Lexington, Kentucky)
ABSTRACT Non-toxigenic fungal strains, and methods of making and use thereof, are provided and have utility as endophytes in forage crops, and as strains that can outcompete toxigenic strains in forage and food crops.
FILED Thursday, June 01, 2017
APPL NO 15/610860
ART UNIT 1662 — Plants
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/52 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6895 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022529 Zheng et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
United States Air Force (USAF)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
Department of Agriculture (USDA)
APPLICANT(S) The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S) The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S) Siyang Zheng (State College, Pennsylvania);  Mauricio Terrones (State College, Pennsylvania);  Yin-Ting Yeh (State College, Pennsylvania);  Yi Tang (State College, Pennsylvania);  Huaguang Lu (State College, Pennsylvania);  Nestor Perea Lopez (State College, Pennsylvania);  Yiqiu Xia (State College, Pennsylvania)
ABSTRACT The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.
FILED Friday, February 07, 2020
APPL NO 16/784507
ART UNIT 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502707 (20130101)
B01L 3/502715 (20130101)
B01L 3/502753 (20130101)
B01L 3/502761 (20130101)
B01L 2200/12 (20130101)
B01L 2200/0668 (20130101)
B01L 2300/12 (20130101)
B01L 2300/041 (20130101)
B01L 2300/0681 (20130101)
B01L 2300/0896 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/405 (20130101) Original (OR) Class
G01N 1/4077 (20130101)
G01N 33/552 (20130101)
G01N 33/54346 (20130101)
G01N 33/56983 (20130101)
G01N 2001/4088 (20130101)
G01N 2333/11 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022672 Chartier et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) Architecture Technology Corporation (Minneapolis, Minnesota)
ASSIGNEE(S) Architecture Technology Corporation (Minneapolis, Minnesota)
INVENTOR(S) Eric Chartier (St. Louis Park, Minnesota);  Paul C. Davis (Saratoga, California);  Ryan L Hagelstrom (Chaska, Minnesota);  Ian J. McLinden (Minneapolis, Minnesota);  Douglas Sweet (Sunnyvale, California)
ABSTRACT A computer-implemented method for establishing and controlling a mobile perimeter and for determining a geographic location of an RF emitting source at or within the mobile perimeter includes receiving from RF sensors in a network, processed RF emissions from the source collected at RF sensors. The RF emissions follow a wireless protocol and include frames encoding RF emitting source identification information. The method further includes extracting RF emitting source identification information from one or more of the frames, processing the source identification information to identify the RF emitting source, and classifying the RF emitting source by one or more of UAS type, UAS capabilities, and UAS model. The method also includes receiving from the RF sensors, a geographic location of each RF sensor and a time of arrival (TOA) of the RF emissions at the RF sensor; and executing a multilateration process to estimate a geographic location of the RF emitting source.
FILED Friday, December 20, 2019
APPL NO 16/723980
ART UNIT 2647 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 5/06 (20130101) Original (OR) Class
G01S 5/0018 (20130101)
G01S 5/021 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 67/12 (20130101)
H04L 67/18 (20130101)

Wireless Communication Networks
H04W 4/021 (20130101)
H04W 4/40 (20180201)
H04W 84/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US PP33116 Deng
FUNDED BY
Department of Agriculture (USDA)
Agricultural Research Service (ARS)
Tropical and Subtropical Agricultural Research (TSTAR)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Florida Foundation Seed Producers, Inc. (Marianna, Florida)
ASSIGNEE(S) Florida Foundation Seed Producers, Inc. (Marianna, Florida)
INVENTOR(S) Zhanao Deng (Riverview, Florida)
ABSTRACT A new and distinct cultivar of Lantana camara plant named ‘UF-1013-1’, characterized by its moderate vigor, mounding growth habit, dense branches, round plant form and canopy, free flowering, bright yellow and red flowers, no to little fruiting, no to few seeds, a very high level of female infertility, a very low level of pollen stainability and viability, a very high level of male infertility, lack of hybridization with Lantana depressa, triploidy and a unique combination of DNA marker alleles, is disclosed.
FILED Wednesday, December 02, 2020
APPL NO 16/974252
ART UNIT 1661 — Plants
CURRENT CPC
New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques
A01H 6/86 (20180501) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 11019862 McBryan et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
ASSIGNEE(S) United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia)
INVENTOR(S) Emily R. McBryan (Houston, Texas);  Jonathan M. Rogers (League City, Texas);  Benjamin J. Peters (Houston, Texas);  Evan Laske (Houston, Texas)
ABSTRACT A grasp assist system includes a glove, finger saddles attached to a respective glove finger, one or more tendon actuators, and artificial tendons. The saddles have a rectangular body partially circumscribing a respective glove finger. Each saddle includes end lobes at opposite distal ends of the body. A first end of each tendon is secured to one of the tendon actuators. A second end forms a triple Brummel loop defining a main loop and two anchor loops. The anchor loops are disposed around the lobes. The saddles may form a rounded, double-headed arrow shape that is at least double the thickness of the body. The finger saddles are anisotropic, with different bending strengths depending on the axis, and may be constructed of thermoplastic polyurethane-coated nylon. Flexion and/or contact sensors and a controller, may be used. A method of connecting the tendon actuator to the finger is also disclosed.
FILED Thursday, April 05, 2018
APPL NO 15/946519
ART UNIT 3732 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting
CURRENT CPC
Outerwear; Protective Garments; Accessories
A41D 19/0006 (20130101)
A41D 19/015 (20130101)
A41D 19/0024 (20130101) Original (OR) Class
A41D 19/0044 (20130101)
A41D 2500/50 (20130101)
A41D 2600/20 (20130101)

Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 25/08 (20130101)
B32B 25/20 (20130101)
B32B 27/08 (20130101)
B32B 27/36 (20130101)
B32B 27/322 (20130101)
B32B 2307/558 (20130101)
B32B 2307/3065 (20130101)
B32B 2307/7265 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11021972 Bailey
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana)
ASSIGNEE(S) Rolls-Royce North American Technologies Inc. (Indianapolis, Indiana)
INVENTOR(S) Patrick Bailey (Lebanon, Indiana)
ABSTRACT A variable pitch blade holder for use with a gas turbine engine. The variable pitch blade holder is configured to retain a blade and to rotate about a center axis with the blade during operation of the gas turbine engine. The blade holder is adapted to rotate about a pitch change axis to vary a pitch of the blade.
FILED Tuesday, August 14, 2018
APPL NO 16/103407
ART UNIT 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/282 (20130101)
F01D 5/3007 (20130101) Original (OR) Class
F01D 7/00 (20130101)

Non-positive-displacement Pumps
F04D 29/322 (20130101)

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2240/20 (20130101)
F05D 2240/80 (20130101)
F05D 2260/941 (20130101)
F05D 2300/603 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023249 Corekin
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S) United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S) Jennifer A. S. Corekin (Odenton, Maryland)
ABSTRACT The present invention relates to a method of reading images using redundant copies and recovery mechanisms to produce valid images, including: reading an OS boot table from a default location in at least one flash memory to at least one DDR SDRAM of a printed circuit board, using at least one processor connected to at least one FPGA; wherein the boot table describes where to find an OS image and a RAM filesystem image in the flash memory; reading a RAM filesystem image from the flash memory into the DDR SDRAM; and validating the boot table and the RAM filesystem image by checking them for corruption using header information and cyclic redundancy check methods; wherein when at least one of the OS image or the RAM filesystem image is corrupt, a valid image can be compiled using valid sections of each of the OS image or the RAM filesystem image.
FILED Wednesday, September 26, 2018
APPL NO 16/142187
ART UNIT 2114 — Computer Error Control, Reliability, & Control Systems
CURRENT CPC
Electric Digital Data Processing
G06F 9/4401 (20130101) Original (OR) Class
G06F 11/1004 (20130101)
G06F 11/1417 (20130101)
G06F 16/18 (20190101)
G06F 16/1734 (20190101)
G06F 21/64 (20130101)
G06F 21/575 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024181 Suddreth et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
ASSIGNEE(S) HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina)
INVENTOR(S) John G. Suddreth (Cave Creek, Arizona);  Marisela Mendez Tapia (San Jose, California);  Jerry Ball (Peoria, Arizona);  Mark Giddings (Mesa, Arizona)
ABSTRACT Avionic display systems and methods are provided for generating avionic displays, which include symbology and other graphics pertaining to forecast overpressure events, which are forecast to occur during supersonic aircraft flight. In various embodiments, the avionic display system includes a display device on which an avionic display is produced. A controller architecture is operably coupled to the display device. Storage media contains computer-readable code or instructions that, when executed by the controller architecture, cause the avionic display system to determine whether an overpressure event is forecast to occur due to the predicted future occurrence of a sonic boom, which has a magnitude exceeding a boom tolerance threshold. When the controller architecture determines that an overpressure event is forecast to occur, the avionic display system further generates symbology on the avionic display indicative of or visually signifying the forecast overpressure event.
FILED Tuesday, September 24, 2019
APPL NO 16/580626
ART UNIT 2685 — Selective Communication
CURRENT CPC
Aeroplanes; Helicopters
B64C 30/00 (20130101)

Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft
B64D 43/00 (20130101)
B64D 45/00 (20130101)

Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry
G01C 23/00 (20130101)

Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves
G01H 1/00 (20130101)
G01H 5/00 (20130101)
G01H 17/00 (20130101)

Traffic Control Systems
G08G 5/0013 (20130101)
G08G 5/0017 (20130101) Original (OR) Class
G08G 5/0021 (20130101)
G08G 5/0052 (20130101)
G08G 5/0069 (20130101)
G08G 5/0086 (20130101)
G08G 5/0091 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11024876 Xu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Department of the Army (DOA)
United States Army (USA)
National Aeronautics and Space Administration (NASA)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Giner, Inc. (Newton, Massachusetts)
ASSIGNEE(S) GINER, INC. (Newton, Massachusetts)
INVENTOR(S) Hui Xu (Acton, Massachusetts);  Jarrod D. Milshtein (Cambridge, Massachusetts);  Katherine Harrison (Arlington, Massachusetts);  Mario Moreira (Hudson, Massachusetts);  Brian Rasimick (Boston, Massachusetts)
ABSTRACT A composite membrane that is suitable for use in an electrochemical cell, an electrochemical cell including the composite membrane, and a method of making the composite membrane. In one embodiment, the composite membrane includes a porous support and a solid electrolyte. The porous support is a unitary structure made of a polymer that is non-conductive to ions. The porous support is shaped to include a plurality of straight-through pores. The solid electrolyte has alkali ion conductivity and preferably completely fills at least some of the pores of the porous support. A variety of techniques may be used to load the solid electrolyte into the pores. According to one technique, the solid electrolyte is melted and then poured into the pores of the porous support. Upon cooling, the electrolyte re-solidifies, forming a monolithic structure within the pores of the porous support.
FILED Wednesday, November 01, 2017
APPL NO 15/801118
ART UNIT 1723 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/02 (20130101)
H01M 4/13 (20130101)
H01M 10/052 (20130101)
H01M 10/0486 (20130101)
H01M 10/0562 (20130101) Original (OR) Class
H01M 2004/027 (20130101)
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11026331 Flatley et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S) United States of America as represented by the Administrator of NASA (Washington, District of Columbia)
INVENTOR(S) Thomas Flatley (Greenbelt, Maryland);  Alessandro Giest (Greenbelt, Maryland);  David Petrick (Greenbelt, Maryland);  Gary Crum (Greenbelt, Maryland);  Milton Davis (Greenbelt, Maryland)
ABSTRACT A single-board computer system radiation hardened for space flight includes a printed circuit board (PCB) having a top side and bottom side; a reconfigurable field programmable gate array (FPGA) processor device a connector disposed on the top side; a plurality of peripheral components mounted on the bottom side, wherein AC coupling capacitors are configured to select routing between the first FPGA and the second FPGA. An expansion card plug attaches to a connector on the bottom of the PCB and a frame is mounted to the PCB.
FILED Friday, September 27, 2019
APPL NO 16/586210
ART UNIT 2848 — Electrical Circuits and Systems
CURRENT CPC
Electric Digital Data Processing
G06F 11/1076 (20130101)

Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/18 (20130101) Original (OR) Class
H05K 1/113 (20130101)
H05K 2201/09309 (20130101)
H05K 2201/09509 (20130101)
H05K 2201/10015 (20130101)
H05K 2201/10159 (20130101)
H05K 2201/10189 (20130101)
H05K 2201/10212 (20130101)
H05K 2201/10545 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Homeland Security (DHS) 

US 11022555 Schumm et al.
FUNDED BY
Department of Homeland Security (DHS)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) ANDE Corporation (Waltham, Massachusetts)
ASSIGNEE(S) ANDE CORPORATION (Waltham, Massachusetts)
INVENTOR(S) James W. Schumm (Lakewood Ranch, Florida);  Richard F. Selden (Lincoln, Massachusetts);  Eugene Tan (Lexington, Massachusetts)
ABSTRACT Provided are methods for multiplex polymerase chain reaction (PCR) amplification of short tandem repeat (STR) loci that can be used to rapidly generate a highly specific STR profile from target nucleic acids. The resulting STR profiles are useful for human identification purposes in law enforcement, homeland security, military, intelligence, and paternity testing applications.
FILED Monday, October 16, 2017
APPL NO 15/784929
ART UNIT 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry
CURRENT CPC
Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 21/04 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6876 (20130101)
C12Q 2600/16 (20130101)
C12Q 2600/156 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6486 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11022592 Zang et al.
FUNDED BY
Department of Homeland Security (DHS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S) University of Utah Research Foundation (Salt Lake City, Utah)
INVENTOR(S) Ling Zang (Salt Lake City, Utah);  Na Wu (Salt Lake City, Utah);  Paul Slattum (Salt Lake City, Utah)
ABSTRACT A chemiresistive vapor sensor compound for detecting target vapors can comprise a perylene-tetracarboxylic diimide (PTCDI) core according to structure (I):
where R can be a morphology control group or -A′-D′, A and A′ can be independently a linking group, D and D′ can be independently a strong electron donor which transfers electrons to the PTCDI core sufficient to form an anionic PTCDI radical of the PTCDI core, and R1 to R8 can be independently a side group. A chemiresistive vapor sensor for detection of a target compound can comprise an assembly of nanofibers formed of the chemiresistive sensor compound and a pair of electrodes operatively oriented about the assembly of nanofibers to allow electrical current to pass from a first electrode in the pair of electrodes through the assembly of nanofibers and to a second electrode in the pair of electrodes.
FILED Friday, December 02, 2016
APPL NO 15/368276
ART UNIT 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry
CURRENT CPC
Heterocyclic Compounds
C07D 471/06 (20130101)

Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 5/62 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/04 (20130101)
G01N 27/127 (20130101)
G01N 33/0037 (20130101)
G01N 33/0057 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023523 Hauptmann et al.
FUNDED BY
Department of Homeland Security (DHS)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) Alexander G. Hauptmann (Finleyville, Pennsylvania)
ASSIGNEE(S) Carnegie Mellon University (Pittsburgh, Pennsylvania)
INVENTOR(S) Alexander G. Hauptmann (Finleyville, Pennsylvania);  Lu Jiang (Pittsburgh, Pennsylvania);  Po-yao Huang (Pittsburgh, Pennsylvania)
ABSTRACT This document describes a search retrieval system for automatically indexing data representing audio-visual recordings and for querying, responsive to a search query, that indexed data representing the audio-visual recordings. The search retrieval system defines weights for semantic features of an audio-visual recording and extracts, based on execution of a first set of rules, one or more semantic features. The system determines a weight for each of the one or more semantic features. A search engine searches nodes in the graph of the semantic features to identify one or more logical relationships for the one or more semantic features extracted. The weights for each of the one or more semantic features are adjusted based on the graph. The data is indexed in association with the one or more adjusted weights for the one or more semantic features, respectively.
FILED Monday, October 24, 2016
APPL NO 15/769233
ART UNIT 2166 — Data Bases & File Management
CURRENT CPC
Electric Digital Data Processing
G06F 16/71 (20190101) Original (OR) Class
G06F 16/78 (20190101)
G06F 16/738 (20190101)
G06F 16/7834 (20190101)
G06F 16/7837 (20190101)
G06F 16/7844 (20190101)

Computer Systems Based on Specific Computational Models
G06N 5/025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 11023569 Eldefrawy et al.
FUNDED BY
Department of Homeland Security (DHS)
APPLICANT(S) SRI International (Menlo Park, California)
ASSIGNEE(S) SRI International (Menlo Park, California)
INVENTOR(S) Karim Eldefrawy (Palo Alto, California);  Tancrede Lepoint (Jersey City, New Jersey)
ABSTRACT An example computing device includes a functional encryption unit configured to generate a master secret key and public key; apply functional encryption using the public key to biometric information of a user to produce functionally encrypted biometric information, the