FedInvent™ Patents
Patent Details for Tuesday, August 24, 2021
This page was updated on Wednesday, August 25, 2021 at 10:31 AM GMT
Department of Health and Human Services (HHS)
| US 11096387 | Hubel et al. |
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| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Allison Hubel (St. Paul, Minnesota); Kathryn Lindsay Pollock (Seattle, Washington) |
| ABSTRACT | This disclosure describes a cryopreservative composition and methods for storing cells. Generally, the cryopreservative composition includes a sugar component and a sugar alcohol component, and is effective for storing and recovering cells without requiring dimethyl sulfoxide (DMSO). |
| FILED | Friday, April 12, 2019 |
| APPL NO | 16/383165 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class A01N 1/0284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096576 | Dave et al. |
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| FUNDED BY |
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| APPLICANT(S) | PlenOptika, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PlenOptika, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Shivang R. Dave (Boston, Massachusetts); Daryl Lim (Singapore, Singapore); Nicholas James Durr (Baltimore, Maryland) |
| ABSTRACT | An apparatus, and corresponding method, for determining a refractive property of an eye includes a housing with a port configured to receive an eye and also light from the eye. A tunable lens can be mounted to the housing to apply a variable focal power to the light from the eye and to pass the light along an optical path toward a wavefront sensor within the housing. The wavefront sensor can receive the light via the optical path and measure a wavefront thereof. A determination module can be configured to determine a property of the eye based on the wavefront. Embodiments can be handheld, portable, and open view, while providing objective wavefront aberrometry, subjective phoroptry, and accommodation and presbyoptic evaluation, as well as lensometry functions. |
| FILED | Tuesday, June 13, 2017 |
| APPL NO | 16/309169 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/005 (20130101) A61B 3/0008 (20130101) A61B 3/09 (20130101) A61B 3/18 (20130101) Original (OR) Class A61B 3/028 (20130101) A61B 3/0033 (20130101) A61B 3/103 (20130101) A61B 3/0285 (20130101) A61B 3/1208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096583 | Emerson et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Robert Wayne Emerson (Durham, North Carolina); Joseph Piven (Pittsboro, North Carolina); Bradley Schlaggar (Towson, Maryland); John Pruett, Jr. (Richmond Heights, Missouri) |
| ABSTRACT | Methods, systems, and computer readable media for utilizing functional connectivity brain imaging for diagnosis of a neurobehavioral disorder are disclosed. One method for utilizing functional connectivity brain imaging for diagnosis of a neurobehavioral disorder includes receiving brain imaging data for a human subject of a first age, wherein the brain imaging data includes functional connectivity magnetic resonance imaging (fcMRI) data, and predicting, using at least one functional connection between brain locations in the fcMRI data, a neurobehavioral disorder diagnosis for the subject at a second age greater than the first age. |
| FILED | Friday, December 28, 2018 |
| APPL NO | 16/235402 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) Original (OR) Class A61B 5/055 (20130101) A61B 5/167 (20130101) A61B 5/168 (20130101) A61B 5/369 (20210101) A61B 5/4064 (20130101) A61B 5/7264 (20130101) A61B 2576/026 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) G01R 33/4808 (20130101) Computer Systems Based on Specific Computational Models G06N 20/10 (20190101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10088 (20130101) G06T 2207/30016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096603 | Majumdar et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Sharmila Majumdar (Alameda, California); John Kurhanewicz (South San Francisco, California); Jeffrey C. Lotz (San Mateo, California); David S. Bradford (Sausalito, California); Kayvan Keshari (Stockton, California) |
| ABSTRACT | NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and at least one of tissue degeneration and pain are made. Accordingly, NMR spectroscopy is used to determine location and/or extent of at least one of degeneration or pain associated with a region of tissue, such as for example in particular disc degeneration, or discogenic pain. NMR spectral peak ratios, such as between N-Acetyl/cho and cho/carb, are readily acquired and analyzed to predict degree of tissue degeneration and/or pain for: tissue samples using HR-MAS spectroscopy; and larger portions of anatomy such as joint segments such as a spine, using clinical 3T MRI systems with surface head or knee coils; and tissue regions such as discs within spines of living patients using 3T MRI systems with a surface spine coil, thus providing a completely non-invasive diagnostic toolset and method to image and localize degeneration and/or pain. |
| FILED | Tuesday, January 09, 2018 |
| APPL NO | 15/866312 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class A61B 5/4514 (20130101) A61B 5/4528 (20130101) A61B 5/4566 (20130101) A61B 5/4824 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/08 (20130101) G01N 33/68 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/00 (20130101) G01R 33/20 (20130101) G01R 33/44 (20130101) G01R 33/46 (20130101) G01R 33/48 (20130101) G01R 33/54 (20130101) G01R 33/465 (20130101) G01R 33/483 (20130101) G01R 33/485 (20130101) G01R 33/4625 (20130101) G01R 33/4828 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096604 | Bailey et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington through its Center for Commercialization (Seattle, Washington) |
| INVENTOR(S) | Michael R. Bailey (Seattle, Washington); Wei Lu (Seattle, Washington); Oleg A. Sapozhnikov (Seattle, Washington); Bryan Cunitz (Seattle, Washington) |
| ABSTRACT | Methods, computing devices, and computer-readable medium are described herein related to producing detection signals configured to induce an excited state of an object. A computing device may receive reflection signals, where the reflection signals correspond to at least one detection signals reflected from the object. Based on the received reflection signals, a presence of the object in the excited state may be determined. Further, an output device may provide an indication of the presence of the object in the excited state. |
| FILED | Thursday, November 01, 2018 |
| APPL NO | 16/178518 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/06 (20130101) Original (OR) Class A61B 5/201 (20130101) A61B 5/0507 (20130101) A61B 8/085 (20130101) A61B 8/488 (20130101) A61B 8/565 (20130101) A61B 8/0833 (20130101) A61B 8/5223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096619 | Barlow et al. |
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| FUNDED BY |
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| APPLICANT(S) | Innara Health (Olathe, Kansas) |
| ASSIGNEE(S) | Innara Health, Inc. (Olathe, Kansas) |
| INVENTOR(S) | Steven M. Barlow (Lawrence, Kansas); David L. Stalling (Olathe, Kansas); Kenneth Aron (Olathe, Kansas) |
| ABSTRACT | A neural analysis and treatment system includes a computing device with a memory for storing an application that is executable on a processor to receive amplitude-integrated electroencephalography (aEEG) and range-EEG (rEEG) measurements associated with a patient. The systems determine a spectral edge frequency (SEF) measurement from the received EEG measurements, and determine one or more neural characteristics of the patient according to the determined SEF, aEEG, and rEEG measurements. These neural characteristics may then be used to identify and implement an appropriate therapeutic treatment. |
| FILED | Monday, July 14, 2014 |
| APPL NO | 14/330712 |
| ART UNIT | 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/374 (20210101) A61B 5/377 (20210101) Original (OR) Class A61B 5/7242 (20130101) A61B 2503/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096654 | Frydman et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Galit Hocsman Frydman (Boston, Massachusetts); Alexander Tyler Jaffe (Cambridge, Massachusetts); Maulik D. Majmudar (Somerville, Massachusetts); Mohamad Ali Toufic Najia (Cambridge, Massachusetts); Robin Singh (Cambridge, Massachusetts); Zijun Wei (Cambridge, Massachusetts); Jason Yang (Charlotte, North Carolina); Brian W. Anthony (Cambridge, Massachusetts); Athena Yeh Huang (Palo Alto, California); Aaron Michael Zakrzewski (Boston, Massachusetts) |
| ABSTRACT | Devices, systems, and methods of the present disclosure are directed to accurate and non-invasive assessments of anatomic vessels (e.g., the internal jugular vein (IJV)) of vertebrates. For example, a piezoelectric crystal may generate a signal and receive a pulse echo of the signal along an axis extending through the piezoelectric crystal and an anatomic vessel. A force sensor disposed relative to the piezoelectric crystal may measure a force exerted (e.g., along skin of the vertebrate) on the anatomic vessel along the axis. The pulse echo received by the piezoelectric crystal and the force measured by the force sensor may, in combination, non-invasively and accurately determine a force response of the anatomic vessel. In turn, the force response may be probative of any one or more of a variety of different characteristics of the anatomic vessel including, for example, location of the anatomic vessel and pressure of the anatomic vessel. |
| FILED | Friday, April 13, 2018 |
| APPL NO | 15/952999 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/022 (20130101) A61B 5/0053 (20130101) A61B 5/02007 (20130101) A61B 5/02133 (20130101) A61B 8/04 (20130101) Original (OR) Class A61B 8/54 (20130101) A61B 8/56 (20130101) A61B 8/58 (20130101) A61B 8/0891 (20130101) A61B 8/4427 (20130101) A61B 8/5223 (20130101) A61B 2090/064 (20160201) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/162 (20130101) G01L 17/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096660 | Konofagou et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Elisa E. Konofagou (New York, New York); Jean Provost (New York, New York); Jianwen Luo (New York, New York); Stanley J. Okrasinski (New York, New York); Stéphane Thiébaut (Antony, France); Vu Thanh-Hieu Nguyen (Lentigny, Switzerland) |
| ABSTRACT | Ultrasound methods, devices, and systems are described which support a useful compromise in terms of spatial resolution and temporal resolution for capturing motion in tissue structures. Tissue engineering articles, methods, systems, and devices which employ ultrasound to deliver biological agents to selected regions of a tissue scaffold, deliver mechanical stimulation to cells growing in a tissue scaffold, and enhance the perfusion of fluids through tissue scaffolds. |
| FILED | Friday, April 08, 2016 |
| APPL NO | 15/094578 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) A61B 8/14 (20130101) A61B 8/461 (20130101) A61B 8/467 (20130101) A61B 8/483 (20130101) A61B 8/0883 (20130101) Original (OR) Class A61B 8/4281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096772 | MacEwan et al. |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Matthew R. MacEwan (St. Louis, Missouri); Jingwei Xie (Chesapeake, Ohio); Zack Ray (St. Louis, Missouri); Younan Xia (Atlanta, Georgia) |
| ABSTRACT | A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229171 |
| ART UNIT | 3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/02 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/22 (20130101) A61L 15/42 (20130101) A61L 27/14 (20130101) A61L 27/50 (20130101) Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0076 (20130101) D01D 5/0092 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/728 (20130101) D04H 3/016 (20130101) D04H 3/073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096774 | Sicotte et al. |
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| FUNDED BY |
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| APPLICANT(S) | ZENFLOW, INC. (San Francisco, California) |
| ASSIGNEE(S) | ZENFLOW, INC. (San Francisco, California) |
| INVENTOR(S) | Marcel Song Sicotte (San Francisco, California); Austin Michael Bly (San Clemente, California); Ben Collett-Nye (Kumeu, New Zealand); Shreya Mehta (San Francisco, California) |
| ABSTRACT | Systems, devices, and methods are provided for the delivery of an implant into the prostatic urethra. Embodiments of delivery systems can include a delivery device for insertion into the patient and a proximal control device for use in controlling release of the implant from the delivery device. |
| FILED | Thursday, June 06, 2019 |
| APPL NO | 16/433463 |
| ART UNIT | 3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3468 (20130101) A61B 2017/00274 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/042 (20130101) Original (OR) Class A61F 2/885 (20130101) A61F 2002/047 (20130101) Gearing F16H 1/06 (20130101) F16H 1/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096893 | Gu et al. |
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| APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | North Carolina State University (Raleigh, North Carolina) |
| INVENTOR(S) | Zhen Gu (Los Angeles, California); Jicheng Yu (Raleigh, North Carolina) |
| ABSTRACT | Disclosed herein are glucose-sensitive drug delivery systems including polymeric shell encapsulating an active agent. Upon exposure to a sufficient concentration of glucose, the shell is ruptured, releasing the active agent for absorption. |
| FILED | Monday, June 04, 2018 |
| APPL NO | 16/618547 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) Original (OR) Class A61K 9/4816 (20130101) A61K 38/28 (20130101) A61K 47/24 (20130101) A61K 47/36 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096899 | Gong et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Shaoqin Gong (Madison, Wisconsin); Zachary Scott Morris (Madison, Wisconsin); Mingzhou Ye (Madison, Wisconsin); Ravi Bhasker Patel (Madison, Wisconsin); Paul M. Sondel (Madison, Wisconsin) |
| ABSTRACT | Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membrane components at least partially coating the polyplex core, wherein the bacterial cell membrane components comprise TLR 2 and/or TLR 4 agonists. Also provided are methods of stimulating an immune response in a mammal using the nanoparticle. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 16/562133 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5068 (20130101) Original (OR) Class A61K 9/5138 (20130101) A61K 39/39 (20130101) A61K 2039/55561 (20130101) A61K 2039/55594 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096900 | Nel et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Andre E. Nel (Sherman Oaks, California); Huan Meng (Los Angeles, California); Xiangsheng Liu (Los Angeles, California) |
| ABSTRACT | A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug. |
| FILED | Wednesday, August 05, 2020 |
| APPL NO | 16/947539 |
| ART UNIT | 1612 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 9/1278 (20130101) A61K 9/5115 (20130101) Original (OR) Class A61K 9/5123 (20130101) A61K 9/5192 (20130101) A61K 31/4745 (20130101) A61K 45/06 (20130101) A61K 47/62 (20170801) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101) Y10S 977/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096923 | Dunman et al. |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Paul M. Dunman (Pittsford, New York); Rachel Wozniak (Pittsford, New York) |
| ABSTRACT | The present invention features an antibacterial composition comprising 1) a composition A comprising polymyxin B and trimethoprim; and 2) an antibiotic agent selected from the group consisting of rifampicin, rifabutin, rifapentine, rifaximin, pefloxacin mesylate, sparfloxacin, sarafloxacin HCl, tobramycin, lomefloxacin, besifloxacin, danofloxacin mesylate, enrofloxacin, nadifloxacin and clinafloxacin, a topical pharmaceutical thereof, and a method of treating bacterial infections using mixtures of 1 and 2. |
| FILED | Wednesday, August 16, 2017 |
| APPL NO | 16/325752 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/395 (20130101) Original (OR) Class A61K 31/395 (20130101) A61K 31/496 (20130101) A61K 31/496 (20130101) A61K 31/505 (20130101) A61K 31/505 (20130101) A61K 31/7036 (20130101) A61K 31/7036 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) A61P 27/06 (20180101) A61P 27/12 (20180101) A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096927 | Tang et al. |
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| FUNDED BY |
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| APPLICANT(S) | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Tallahassee, Florida); The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Tallahassee, Florida); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland); THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Hengli Tang (Tallahassee, Florida); Emily M. Lee (Tallahassee, Florida); Wei Zheng (Rockville, Maryland); Ruili Huang (Rockville, Maryland); Miao Xu (Rockville, Maryland); Wenwei Huang (Rockville, Maryland); Khalida Shamim (Rockville, Maryland); Guoli Ming (Philadelphia, Pennsylvania); Hongjun Song (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections. |
| FILED | Thursday, December 19, 2019 |
| APPL NO | 16/721221 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) A61K 31/245 (20130101) A61K 31/336 (20130101) A61K 31/352 (20130101) A61K 31/422 (20130101) A61K 31/427 (20130101) A61K 31/433 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/519 (20130101) A61K 31/554 (20130101) A61K 31/4162 (20130101) A61K 31/4184 (20130101) Original (OR) Class A61K 31/4535 (20130101) A61K 31/4709 (20130101) A61K 31/4741 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096934 | Sykes et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); BAYER PHARMA AKTIENGESELLSCHAFT (Berlin, Germany) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); BAYER PHARMA AKTIENGESELLSCHAFT (Berlin, Germany) |
| INVENTOR(S) | David B. Sykes (Boston, Massachusetts); David Scadden (Boston, Massachusetts); Timothy A. Lewis (Cambridge, Massachusetts); Andreas Janzer (Berlin, Germany); Hanna Meyer (Berlin, Germany); Detlef Stöckigt (Potsdam, Germany) |
| ABSTRACT | The present invention includes methods of treating patients with acute myeloid leukemia across a range of genetic subtypes with DHODH inhibitors, such as 6-fluoro-2-(2′-fluoro-[1,1′-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid). |
| FILED | Monday, August 29, 2016 |
| APPL NO | 15/756469 |
| ART UNIT | 1619 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/42 (20130101) A61K 31/47 (20130101) Original (OR) Class A61K 31/277 (20130101) A61K 31/505 (20130101) A61K 33/36 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096953 | Desimone et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Joseph Desimone (Glen Ellyn, Illinois); Yogen Saunthararajah (Cleveland, Ohio) |
| ABSTRACT | Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly. |
| FILED | Friday, November 15, 2019 |
| APPL NO | 16/685956 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7068 (20130101) Original (OR) Class A61K 31/7068 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096956 | Aznarez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Stoke Therapeutics, Inc. (Bedford, Massachusetts); Cold Spring Harbor Laboratory (Cold Spring Harbor, New York) |
| ASSIGNEE(S) | STOKE THERAPEUTICS, INC. (Bedford, Massachusetts); COLD SPRING HARBOR LABORATORY (Cold Sping Harbor, New York) |
| INVENTOR(S) | Isabel Aznarez (Jamaica Plain, Massachusetts); Huw M. Nash (Lexington, Massachusetts); Adrian Krainer (East Northport, New York) |
| ABSTRACT | Provided herein are methods and compositions for increasing the expression of a protein, and for treating a subject in need thereof, e.g., a subject with deficient protein expression or a subject having a disease described herein. |
| FILED | Wednesday, June 13, 2018 |
| APPL NO | 16/007435 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7125 (20130101) Original (OR) Class A61K 38/005 (20130101) A61K 38/179 (20130101) A61K 47/6807 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) C12N 15/111 (20130101) C12N 15/1136 (20130101) C12N 2310/11 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/321 (20130101) C12N 2310/3521 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096965 | Balin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); ULM UNIVERSITY (Ulm, Germany) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); ULM UNIVERSITY (Ulm, Germany) |
| INVENTOR(S) | Samuel J. Balin (Playa Del Rey, California); Robert L. Modlin (Sherman Oaks, California); Steffen Stenger (Ulm, Germany); Matteo Pellegrini (Sherman Oaks, California) |
| ABSTRACT | Various aspects of the invention relate to compositions comprising polycytotoxic T cells. Some aspects relate to methods for obtaining a composition comprising polycytotoxic T cells. Some aspects relate to methods of administering a composition comprising polycytotoxic T cells to a subject. Some aspects relate to methods for monitoring an immune response in a subject, comprising determining the concentration of polycytotoxic T cells in the blood of the subject. Some aspects relate to methods for treating a condition or disease in a subject, comprising administering to the subject a composition comprising an antibody, or an antigen-binding portion thereof, that specifically binds to a protein expressed by a polycytotoxic T cell. |
| FILED | Tuesday, April 04, 2017 |
| APPL NO | 16/091029 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/20 (20130101) A61K 38/2013 (20130101) A61K 38/2046 (20130101) A61K 38/2086 (20130101) A61K 45/06 (20130101) Peptides C07K 16/2866 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 1/6886 (20130101) C12Q 1/6888 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0656 (20130101) G01N 33/505 (20130101) G01N 33/56972 (20130101) G01N 2015/008 (20130101) G01N 2015/0693 (20130101) G01N 2800/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096972 | Miles et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan-Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Linde Miles (New York, New York); John Poirier (New York, New York); Charles Rudin (New York, New York) |
| ABSTRACT | A method for selecting cancer patient for treatment with Seneca Valley Virus (SVV) by determining expression of ANTXR1 in a cancerous tissue in a cancer patient; and designating the cancer patient as a candidate for treatment with SVV if normal levels or elevated levels of ANTXR1 expression is detected in the cancerous tissue. Also a method for treating a cancer patient with SVV is disclosed. |
| FILED | Monday, January 20, 2020 |
| APPL NO | 16/747433 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/768 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2770/32033 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57484 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096989 | Wittrup et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Karl Dane Wittrup (Chestnut Hill, Massachusetts); Jennifer R. Cochran (Stanford, California); Byron Hua Kwan (Seattle, Washington) |
| ABSTRACT | The present invention provides a method of treating cancer with a combination of IL-2 and an integrin-binding-Fc fusion protein. The methods of the invention can be applied to a broad range of cancer types. |
| FILED | Friday, December 21, 2018 |
| APPL NO | 16/230466 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) A61K 38/179 (20130101) A61K 38/179 (20130101) A61K 38/385 (20130101) A61K 38/2013 (20130101) Original (OR) Class A61K 38/2013 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 47/64 (20170801) A61K 2039/505 (20130101) A61K 2039/507 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Peptides C07K 14/55 (20130101) C07K 16/22 (20130101) C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/40 (20130101) C07K 16/249 (20130101) C07K 16/2803 (20130101) C07K 16/2812 (20130101) C07K 16/2815 (20130101) C07K 16/2818 (20130101) C07K 16/3053 (20130101) C07K 2317/52 (20130101) C07K 2317/71 (20130101) C07K 2317/76 (20130101) C07K 2319/30 (20130101) C07K 2319/31 (20130101) C07K 2319/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096997 | Mooney et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Regents of the University of Michigan (Ann Arbor, Michigan) |
| INVENTOR(S) | David J. Mooney (Sudbury, Massachusetts); Omar Abdel-Rahman Ali (Oakland, California); Eduardo Alexandre Barros E Silva (Davis, California); Hyun Joon Kong (Cambridge, Massachusetts); Elliot Earl Hill, Jr. (Ypsilanti, Michigan); Tanyarut Boontheekul (Bangkok, Thailand) |
| ABSTRACT | A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material. |
| FILED | Thursday, October 25, 2018 |
| APPL NO | 16/170313 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/1647 (20130101) A61K 38/39 (20130101) A61K 38/193 (20130101) A61K 38/1866 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/21 (20130101) A61K 39/39 (20130101) A61K 39/00117 (20180801) A61K 39/00118 (20180801) A61K 39/001156 (20180801) A61K 39/001171 (20180801) A61K 39/001182 (20180801) A61K 39/001184 (20180801) A61K 39/001186 (20180801) A61K 39/001191 (20180801) A61K 39/001192 (20180801) A61K 39/001195 (20180801) A61K 2039/54 (20130101) A61K 2039/6093 (20130101) A61K 2039/55516 (20130101) A61K 2039/55522 (20130101) A61K 2039/55561 (20130101) A61K 2039/55583 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/20 (20130101) A61L 27/38 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/58 (20130101) A61L 27/3633 (20130101) A61L 27/3826 (20130101) A61L 2300/232 (20130101) A61L 2300/252 (20130101) A61L 2300/412 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) A61L 2300/438 (20130101) A61L 2300/604 (20130101) A61L 2300/606 (20130101) A61L 2400/18 (20130101) A61L 2430/30 (20130101) A61L 2430/34 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/117 (20130101) C12N 2310/17 (20130101) C12N 2320/32 (20130101) C12N 2740/16034 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097002 | He et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Linling He (San Diego, California); Jiang Zhu (San Diego, California) |
| ABSTRACT | The present invention provides novel nanoparticle presented vaccine compositions that are stabilized with a locking domain. Various immunogens can be employed in the preparation of the vaccine compositions, including viral immunogens such as HIV-1 and Ebola viral immunogens, and non-viral immunogens such as immunogens derived from bacteria, parasites and mammalian species. The invention also provides methods of using such vaccine compositions in various therapeutic applications, e.g., for preventing or treating viral infections. |
| FILED | Thursday, June 13, 2019 |
| APPL NO | 16/440067 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Original (OR) Class A61K 47/6425 (20170801) A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097005 | Brenner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Michael B. Brenner (Newton, Massachusetts); Sook Kyung Chang (Gyeonggi-do, South Korea); Lydia Lynch (Newton, Massachusetts) |
| ABSTRACT | Provided herein are methods and pharmaceutical compositions for the treatment of obesity-associated conditions using cadherin-11 antagonists. |
| FILED | Tuesday, December 15, 2015 |
| APPL NO | 15/536072 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 39/395 (20130101) A61K 45/06 (20130101) Original (OR) Class A61K 2039/505 (20130101) Peptides C07K 16/28 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097014 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio); The Board of Trustees of the University of Illinois (Chicago, Illinois); The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio); Board of Trustees of the University of Illinois (Chicago, Illinois); University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Jianjun Chen (Cincinnati, Ohio); Seungpyo Hong (Naperville, Illinois); Xi Jiang (Cincinnati, Ohio); Zejuan Li (Chicago, Illinois) |
| ABSTRACT | A nanoparticle delivery system designed for sustained delivery of microRNA-150 (miR-150) to FLT3-overexpressing acute myeloid leukemia (AML) cells, the delivery system comprising poly(amidoamine) (PAMAM) dendrimers complexed with miR-150, wherein at least one dendrimer is surface-functionalized with a ligand specific for FLT3 receptor, and methods for treating AML characterized by FLT3-overexpression are provided. |
| FILED | Wednesday, June 14, 2017 |
| APPL NO | 16/310104 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/551 (20130101) A61K 31/551 (20130101) A61K 31/7105 (20130101) A61K 38/19 (20130101) A61K 45/06 (20130101) A61K 47/62 (20170801) A61K 47/595 (20170801) A61K 47/6935 (20170801) Original (OR) Class A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/141 (20130101) C12N 2310/321 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097017 | Preihs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Christian Preihs (Dallas, Texas); Jing Yu (Coppell, Texas); Veronica Clavijo Jordan (Dallas, Texas); Yunkou Wu (Coppell, Texas); Khaled Nasr (Dallas, Texas); A. Dean Sherry (Dallas, Texas); Sara Chirayil (Plano, Texas) |
| ABSTRACT | In some aspects, the present disclosure provides novel ligands, which may be used to make novel MRI contrast agents for the detection of zinc. In further aspects, by the present disclosure also provides methods of using as imaging agents and compositions thereof. |
| FILED | Monday, January 14, 2019 |
| APPL NO | 16/246890 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/106 (20130101) A61K 49/108 (20130101) Original (OR) Class Heterocyclic Compounds C07D 213/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097018 | Sharma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Vijay Sharma (St. Louis, Missouri); Jothilingam Sivapackiam (St. Louis, Missouri); Sundaram S. M. Guruswami (St. Louis, Missouri) |
| ABSTRACT | Provided herein are compounds for the imaging and treatment of TDP43-mediated disorders. The compounds disclosed bind TDP43 aggregates and may be used to diagnose and treat amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). |
| FILED | Thursday, September 06, 2018 |
| APPL NO | 16/123845 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/343 (20130101) A61K 31/375 (20130101) A61K 31/436 (20130101) A61K 45/06 (20130101) A61K 51/0453 (20130101) Original (OR) Class A61K 51/0455 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 215/22 (20130101) C07D 215/38 (20130101) C07D 277/64 (20130101) C07D 277/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097019 | Heller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Daniel Heller (New York, New York); Januka Budhathoki-Uprety (New York, New York) |
| ABSTRACT | Described herein are suspensions of helical polycarbodiimide polymers that ‘cloak’ nanotubes, thereby effecting control over nanotube emission, providing a new mechanism of environmental responsivity, and enabling precise control over sub-cellular localization. The helical polycarbodiimide polymers described herein are water soluble, easily modifiable, and have unique architectures that facilitate their application in radiopharmaceutical delivery and imaging methods, in therapeutics and therapeutic delivery methods, and their use as sensors—both in conjunction with carbon nanotubes, and without nanotubes. |
| FILED | Monday, December 31, 2018 |
| APPL NO | 16/237492 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/59 (20170801) A61K 47/6927 (20170801) A61K 51/065 (20130101) Original (OR) Class A61K 51/1251 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/168 (20170801) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/542 (20130101) G01N 33/587 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097090 | Vasilyev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Nikolay V. Vasilyev (Newton, Massachusetts); Pedro J. del Nido (Lexington, Massachusetts); Tonatiuh M. Lievano Beltran (Cuernavaca, Mexico); Erik A. Kraus (Hillsborough, North Carolina); Nikhil Mehandru (Roslyn, New York); Evelyn J. Park (Rolling Hills Estates, California); Conor J. Walsh (Cambridge, Massachusetts); Isaac Wamala (Jamaica Plain, Massachusetts); Markus Horvath (Cambridge, Massachusetts) |
| ABSTRACT | Methods and apparatuses relate to an implantable device for providing contractile assistance to an organ. The device may include an actuator and anchors located on either side of the actuator. The anchors engage with oppositely positioned tissue walls of an organ chamber, and provide contractile assistance to the organ, repeatedly, at appropriate times. For example, the device may be implanted within the right ventricle, anchored to the right ventricular free wall and the ventricular septum. The device may function to bring the opposing walls of the ventricle toward one another, synchronized with the pacing of the heart, resulting in an improved ejection fraction of blood from the chamber. In some embodiments, the actuator includes a bladder that is configured to contract upon receiving an inflow of pressurized fluid therein. When the fluid exits therefrom, the bladder relaxes back to an initial, extended state. |
| FILED | Wednesday, March 28, 2018 |
| APPL NO | 15/938680 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/283 (20210101) A61B 17/0401 (20130101) A61B 2017/00243 (20130101) A61B 2017/0404 (20130101) A61B 2017/0417 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/40 (20210101) A61M 60/50 (20210101) A61M 60/122 (20210101) A61M 60/148 (20210101) Original (OR) Class A61M 60/187 (20210101) A61M 60/268 (20210101) A61M 60/857 (20210101) A61M 2205/32 (20130101) A61M 2205/33 (20130101) A61M 2205/0283 (20130101) A61M 2205/3303 (20130101) A61M 2230/04 (20130101) A61M 2230/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097120 | Efimov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | The Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Igor R. Efimov (Wildwood, Missouri); Wenwen Li (St. Louis, Missouri); Ajit Janardhan (St. Louis, Missouri) |
| ABSTRACT | Methods and apparatus for a three-stage atrial cardioversion therapy that treats atrial arrhythmias within pain tolerance thresholds of a patient. An implantable therapy generator adapted to generate and selectively deliver a three-stage atrial cardioversion therapy and at least two leads, each having at least one electrode adapted to be positioned proximate the atrium of the patient. The device is programmed for delivering a three-stage atrial cardioversion therapy via both a far-field configuration and a near-field configuration of the electrodes upon detection of an atrial arrhythmia. The three-stage atrial cardioversion therapy includes a first stage for unpinning of one or more singularities associated with an atrial arrhythmia, a second stage for anti-repinning of the one or more singularities, both of which are delivered via the far-field configuration of the electrodes, and a third stage for extinguishing of the one or more singularities delivered via the near-field configuration of the electrodes. |
| FILED | Tuesday, August 06, 2019 |
| APPL NO | 16/533355 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/395 (20130101) A61N 1/3624 (20130101) A61N 1/3906 (20130101) A61N 1/3956 (20130101) Original (OR) Class A61N 1/3987 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097122 | Lu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Daniel C. Lu (Los Angeles, California) |
| ABSTRACT | In various embodiments methods and devices are provided for facilitating locomotor function and/or voiding of bladder and/or bowel in a subject with a neuromotor disorder. In certain embodiments the methods involve providing magnetic stimulation of the spinal cord at a location, frequency and intensity sufficient to facilitate locomotor function and/or voiding of bladder and/or bowel. |
| FILED | Friday, November 04, 2016 |
| APPL NO | 15/344381 |
| ART UNIT | 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36017 (20130101) A61N 1/36034 (20170801) A61N 2/02 (20130101) A61N 2/004 (20130101) A61N 2/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098008 | Blagg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF KANSAS (Lawrence, Kansas) |
| ASSIGNEE(S) | UNIVERSITY OF KANSAS (Lawrence, Kansas) |
| INVENTOR(S) | Brian S. J. Blagg (Lawrence, Kansas); Rick T. Dobrowsky (Olathe, Kansas); Mercy Anyika (Lawrence, Kansas) |
| ABSTRACT | Provided herein are compounds of the formulas: wherein: n, X2, R3, R3′, R4, R4′, R5, R5′, R6, and R6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer. |
| FILED | Wednesday, January 29, 2020 |
| APPL NO | 16/776091 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 233/18 (20130101) Original (OR) Class C07C 2601/08 (20170501) C07C 2601/14 (20170501) C07C 2601/16 (20170501) Heterocyclic Compounds C07D 307/20 (20130101) C07D 309/10 (20130101) C07D 311/08 (20130101) C07D 311/16 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098017 | Raines |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Douglas Raines (Wayland, Massachusetts) |
| ABSTRACT | The present application provides compounds useful for treating disorders associated with abnormal steroidogenesis. Methods of treating disorders associated with abnormal steroidogenesis, methods of inhibiting 11β-hydroxylase activity, and pharmaceutical compositions comprising the compounds are also provided. |
| FILED | Thursday, May 17, 2018 |
| APPL NO | 16/651248 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 5/00 (20180101) Heterocyclic Compounds C07D 233/90 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098021 | Cheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); Albert Einstein College of Medicine, Inc. (Bronx, New York) |
| ASSIGNEE(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); Albert Einstein College of Medicine, Inc. (Bronx, New York) |
| INVENTOR(S) | Emily H. Cheng (Englewood Cliffs, New Jersey); Paul Jeng (New Rochelle, New York); Ouathek Ouerfelli (Fort Lee, New Jersey); James Hsieh (Englewood Cliffs, New Jersey); Guangli Yang (Syosset, New York); Evripidis Gavathiotis (Flushing, New York) |
| ABSTRACT | Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and kits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or preventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune diseases) in a subject. The compounds and pharmaceutical compositions as described herein inhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or prevent a proliferative disease. In certain embodiments, compounds described herein are selective inhibitors of MCL-1, a BCL-2 family member protein. |
| FILED | Friday, August 12, 2016 |
| APPL NO | 15/752126 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/343 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) A61P 35/00 (20180101) A61P 35/02 (20180101) A61P 37/00 (20180101) Heterocyclic Compounds C07D 307/82 (20130101) C07D 307/84 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098033 | Turchi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Indianapolis, Indiana) |
| ASSIGNEE(S) | Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| INVENTOR(S) | John J Turchi (Indianapolis, Indiana); Navnath Gavande (Indianapolis, Indiana); Pamela S. Vandervere-Carozza (Zionsville, Indiana) |
| ABSTRACT | The present disclosure relates to certain compounds having binding affinity for Ku, and uses thereof. Specifically, the present disclosure relates to the use of Ku inhibitors as described herein in site-specific genome engineering technologies, including but not limited to CRISPR/Cas9, Zinc finger nuclease (ZFN), Transcription activator-like effector nuclease (TALEN), and meganuclease. The present disclosure also relates to kits useful for site-specific genome engineering that include at least one compound as described herein. |
| FILED | Wednesday, May 24, 2017 |
| APPL NO | 16/303454 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Heterocyclic Compounds C07D 405/06 (20130101) C07D 405/14 (20130101) Original (OR) Class C07D 409/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098043 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Wei Zhang (Boston, Massachusetts); Alex Mugwiria Muthengi (Malden, Massachusetts); Hailemichael O. Yosief (Cincinnati, Ohio) |
| ABSTRACT | This disclosure relates to compounds that are CBP inhibitor and methods of using such compounds in the treatment and diagnosis of diseases and disorders. |
| FILED | Friday, July 13, 2018 |
| APPL NO | 16/629408 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098052 | Pettit et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | George Robert Pettit (Paradise Valley, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | George Robert Pettit (Paradise Valley, Arizona); Justin Searcy (Loveland, Colorado) |
| ABSTRACT | The present disclosure relates to 4-azapodophylotoxins compounds, pharmaceutical compositions comprising such compounds, kits, and methods for using such compounds or pharmaceutical compositions. |
| FILED | Thursday, March 02, 2017 |
| APPL NO | 16/081683 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 491/14 (20130101) C07D 491/048 (20130101) Original (OR) Class C07D 491/153 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098053 | Strong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana); XAVIER UNIVERSITY OF LOUISIANA (New Orleans, Louisiana); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana); XAVIER UNIVERSITY OF LOUISIANA (New Orleans, Louisiana); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| INVENTOR(S) | Amy Strong (New Orleans, Louisiana); Stephen Boue (Washington, District of Columbia); Matthew Burow (New Orleans, Louisiana); Bruce Bunnell (New Orleans, Louisiana); Quan Jiang (New Orleans, Louisiana); Shilong Zheng (New Orleans, Louisiana); Guangdi Wang (New Orleans, Louisiana) |
| ABSTRACT | Disclosed are daidzein analogs having the formula (I). Also disclosed are compositions, include a disclosed daidzein analogs, methods of preventing or treating bone disease or bone injury and/or stimulating bone growth, in a subject that include administering to the subject an effective amount of disclosed daidzein analog. Disclosed are isolated mesenchymal stem cell that has been altered by treatment a disclosed daidzein analog, daidzein, glycinol, glyceollin I, or glyceollin II, to increase the osteogenic potential of the mesenchymal stem cells. |
| FILED | Friday, April 04, 2014 |
| APPL NO | 14/781494 |
| ART UNIT | 1619 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/352 (20130101) A61K 35/28 (20130101) A61K 35/28 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 2300/412 (20130101) A61L 2430/02 (20130101) Heterocyclic Compounds C07D 311/04 (20130101) C07D 311/36 (20130101) C07D 493/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098054 | Beutler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland); Fundacio Institut Catala D'Investigacio Quimica (Tarragona, Spain); University of Delaware (Newark, Delaware); University of Leeds (Leeds, United Kingdom); Universitat Rovira I Virgili (Tarragona, Spain) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Sciences (Bethesda, Maryland); Fundacio Institut Catala D'Investigacio Quimica (Tarragona, Spain); University of Delaware (Newark, Delaware); University of Leeds (Leeds, United Kingdom); Universitat Rovira I Virgili (Tarragona, Spain) |
| INVENTOR(S) | John A. Beutler (Union Bridge, Maryland); Antonio Echavarren (Tarragona, Spain); William Chain (Newark, Delaware); David Beech (Leeds, United Kingdom); Zhenhua Wu (Newark, Delaware); Jean-Simon Suppo (Tarragona, Spain); Fernando Bravo (Tarragona, Spain); Hussein Rubaiy (Leeds, United Kingdom) |
| ABSTRACT | Disclosed is a compound of formula (I) in which a, R1-R5 and X1 are as described herein. Also disclosed are a pharmaceutical composition containing the compound and a method of using the compound for treating cancer, such as renal cancer. |
| FILED | Thursday, July 05, 2018 |
| APPL NO | 16/628768 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 471/08 (20130101) C07D 493/08 (20130101) Original (OR) Class C07D 495/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098072 | Dowd et al. |
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| FUNDED BY |
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| APPLICANT(S) | The George Washington University (Washington, District of Columbia); Washington University in St. Louis (St. Louis, Missouri); George Mason University (Fairfax, Virginia); Saint Louis University (St. Louis, Missouri) |
| ASSIGNEE(S) | The George Washington University, A Congressionally Chartered Not-for-Profit Corporation (Washington, District of Columbia); Washington University (St. Louis, Missouri); George Mason University (Fairfax, Virginia); St. Louis University (St. Louis, Missouri) |
| INVENTOR(S) | Cynthia Dowd (Washington, District of Columbia); Xu Wang (Washington, District of Columbia); Robert Carl Brothers (Washington, District of Columbia); Audrey Ragan Odom John (St. Louis, Missouri); Rachel Edwards (St. Louis, Missouri); Marvin Meyers (St. Louis, Missouri); Stacy Arnett (St. Louis, Missouri); Robin Couch (Fairfax, Virginia); Kenneth Heidel (Washington, District of Columbia) |
| ABSTRACT | The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are α,β-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum. |
| FILED | Wednesday, June 27, 2018 |
| APPL NO | 16/627004 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) A61P 33/06 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/3826 (20130101) Original (OR) Class C07F 9/4015 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098082 | Van de Water et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Judy Van de Water (Capay, California); Elizabeth Edmiston (Sacramento, California) |
| ABSTRACT | The present invention provides peptides that specifically bind to maternal autoantibodies that are generated in the mother or potential mother against one or more endogenous polypeptide antigens selected from lactate dehydrogenase A (LDH A), lactate dehydrogenase B (LDH B), stress-induced phosphoprotein 1 (STIP1), guanine deaminase (GDA), Y Box Binding Protein 1 (YBX1), collapsin response mediator protein 1 (CRMP1), and collapsin response mediator protein 2 (CRMP2). The peptides described herein are useful for determining a risk of an offspring for developing an autism spectrum disorder (ASD) by detecting the presence of maternal autoantibodies in a biological sample of the mother or potential mother. The peptides or mimotopes thereof can also be administered to the mother or potential mother to block the binding between maternal autoantibodies and their antigens, thereby neutralizing the maternal autoantibodies. |
| FILED | Tuesday, December 19, 2017 |
| APPL NO | 15/847477 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Peptides C07K 7/08 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/564 (20130101) G01N 2800/28 (20130101) G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098084 | Nabel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Gary J. Nabel (Chestnut Hill, Massachusetts); Srinivas Rao (Columbia, Maryland); Wataru Akahata (Kensington, Maryland) |
| ABSTRACT | The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the modified VLPs. The invention also features methods for enhancing production of modified VLPs for use in the prevention or treatment of alphavirus and flavivirus-mediated diseases. The invention also provides methods for delivering agents to a cell using the modified VLPs. |
| FILED | Monday, November 26, 2018 |
| APPL NO | 16/199671 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/53 (20130101) A61K 2039/575 (20130101) A61K 2039/5258 (20130101) A61K 2039/55566 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/36122 (20130101) C12N 2770/36123 (20130101) C12N 2770/36134 (20130101) C12N 2770/36151 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098088 | Lightfoot et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| INVENTOR(S) | Yaima L. Lightfoot (Washington, District of Columbia); Bikash Sahay (Gainesville, Florida); Mansour Mohamadzadeh (Gainesville, Florida) |
| ABSTRACT | The current invention provides a recombinant bacterium, the recombinant bacterium being genetically modified to decrease or eliminate the display of lipoteichoic acid (LTA), surface layer protein B (SlpB) and surface layer protein X (SlpX) on the surface of said bacterium. Efficacious therapies for a subject suffering from an inflammation mediated disease are also provided. The methods of the current invention comprise administering to a subject in need thereof a therapeutically effective amount of the recombinant L. acidophilus cells or a therapeutically effective amount of the isolated surface layer protein A (SlpA) or a non-naturally occurring derivative thereof. The recombinant L. acidophilus cells or SlpA isolated from L. acidophilus can be in a pharmaceutical composition comprising a pharmaceutically acceptable carrier and/or excipient. In an embodiment of the invention, the pharmaceutical composition is administered orally. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 16/790793 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/747 (20130101) A61K 38/13 (20130101) A61K 38/164 (20130101) Peptides C07K 14/335 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/746 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098092 | Spiegelman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Bruce M. Spiegelman (Waban, Massachusetts); Pontus Bostrom (Gothenburg, Sweden) |
| ABSTRACT | The invention provides compositions and methods for brown fat induction and activity through modulation of Fndc5 activity and/or expression. Also provided are methods for preventing or treating metabolic disorders in a subject through modulation of Fndc5 activity and/or expression. Further provided are methods for identifying compounds that are capable of modulating Fndc5 activity and/or expression. |
| FILED | Tuesday, September 04, 2018 |
| APPL NO | 16/121211 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Peptides C07K 14/47 (20130101) Original (OR) Class C07K 14/78 (20130101) C07K 14/435 (20130101) C07K 14/575 (20130101) C07K 16/18 (20130101) C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2330/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098100 | Vallera et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Daniel Attilio Vallera (Richfield, Minnesota); Jeffrey S. Miller (Little Canada, Minnesota) |
| ABSTRACT | This disclosure describes engineered compounds that engage NK cells and methods of using the compounds. Generally, the compound includes an NK engaging domain, a targeting domain that selectively binds to a target cell, and an NK activating domain operably linking the NK engaging domain and the targeting domain. |
| FILED | Thursday, October 06, 2016 |
| APPL NO | 15/766067 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Peptides C07K 14/55 (20130101) Original (OR) Class C07K 14/5443 (20130101) C07K 16/244 (20130101) C07K 16/283 (20130101) C07K 16/1045 (20130101) C07K 16/2803 (20130101) C07K 16/2809 (20130101) C07K 2317/22 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/622 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098101 | Vallera et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Daniel Attilio Vallera (Richfield, Minnesota); Jeffrey S. Miller (Little Canada, Minnesota) |
| ABSTRACT | This disclosure describes engineered compounds that engage NK cells and methods of using the compounds. Generally, the compound includes an NK engaging domain, a targeting domain that selectively binds to a target cell, and an NK activating domain operably linking the NK engaging domain and the targeting domain. |
| FILED | Thursday, September 05, 2019 |
| APPL NO | 16/561587 |
| ART UNIT | 1643 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Peptides C07K 14/55 (20130101) Original (OR) Class C07K 14/5443 (20130101) C07K 16/30 (20130101) C07K 16/244 (20130101) C07K 16/283 (20130101) C07K 16/1045 (20130101) C07K 16/2803 (20130101) C07K 16/2809 (20130101) C07K 2317/22 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/622 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098150 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| INVENTOR(S) | Jinming Gao (Plano, Texas); David Boothman (Dallas, Texas); Kejin Zhou (Dallas, Texas); Xiaonan Huang (Beijing, China PRC); Yiguang Wang (Dallas, Texas) |
| ABSTRACT | Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications. |
| FILED | Wednesday, June 13, 2018 |
| APPL NO | 16/006885 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) A61K 9/1273 (20130101) A61K 9/5031 (20130101) A61K 31/337 (20130101) A61K 31/352 (20130101) A61K 31/704 (20130101) A61K 47/58 (20170801) A61K 47/62 (20170801) A61K 47/6811 (20170801) A61K 47/6845 (20170801) A61K 47/6907 (20170801) A61K 49/005 (20130101) A61K 49/0032 (20130101) A61K 49/0054 (20130101) A61K 49/0056 (20130101) A61K 49/0082 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 311/92 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/34 (20130101) C08F 293/005 (20130101) Original (OR) Class C08F 299/024 (20130101) C08F 2438/01 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 81/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098283 | Gautam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Sanjivan Gautam (Rockville, Maryland); Yun Ji (Germantown, Maryland); Luca Gattinoni (Washington, District of Columbia) |
| ABSTRACT | Provided is an isolated or purified T cell comprising an antigen-specific receptor, wherein the antigen-specific receptor is a T cell receptor (TCR) or a chimeric antigen receptor (CAR), wherein the T cell has been modified to express a transcription factor at a level that is higher than the level of the transcription factor expressed by a T cell that has not been modified to express the transcription factor, wherein the transcription factor is V-Myb Avian Myeloblastosis Viral Oncogene Homolog (c-Myb), a functional variant of c-Myb, or a functional fragment of c-Myb. Related populations of cells, pharmaceutical compositions, methods of treating a disease, and methods of inhibiting the differentiation of T cells are also provided. |
| FILED | Wednesday, August 24, 2016 |
| APPL NO | 15/754078 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2035/124 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) A61P 35/00 (20180101) Peptides C07K 14/82 (20130101) C07K 14/7051 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098284 | Yee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| ASSIGNEE(S) | The Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| INVENTOR(S) | Cassian Yee (Seattle, Washington); Yongqing Li (Shoreline, Washington) |
| ABSTRACT | A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount is described. In the method, the CTL preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate CTL population, the CTL population: (i) depleted of FoxP3+ T lymphocytes prior to antigen stimulation, (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of FoxP3+ T lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. Methods of preparing such compositions, and compositions useful for carrying out the adoptive immunotherapy, are also described. |
| FILED | Thursday, August 09, 2018 |
| APPL NO | 16/100113 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/41 (20130101) A61K 35/12 (20130101) A61K 35/17 (20130101) A61K 39/00 (20130101) A61K 2035/124 (20130101) A61K 2039/51 (20130101) A61K 2039/5154 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) Original (OR) Class C12N 2501/23 (20130101) C12N 2501/998 (20130101) C12N 2501/2321 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098302 | Robinson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | William H. Robinson (Palo Alto, California); Yann Chong Tan (Palo Alto, California); Jeremy Sokolove (Mountain View, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as Represented by the Department of Veterans Affair (Washington, District of Columbia) |
| INVENTOR(S) | William H. Robinson (Palo Alto, California); Yann Chong Tan (Palo Alto, California); Jeremy Sokolove (Mountain View, California) |
| ABSTRACT | Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest. |
| FILED | Friday, April 27, 2012 |
| APPL NO | 13/261763 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 16/00 (20130101) C07K 16/1242 (20130101) C07K 16/1271 (20130101) C07K 2317/21 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 2458/10 (20130101) G01N 2500/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098303 | Zhuang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Xiaowei Zhuang (Lexington, Massachusetts); Kok-Hao Chen (Singapore, Singapore); Alistair Boettiger (Cambridge, Massachusetts); Jeffrey R. Moffitt (Somerville, Massachusetts); Siyuan Wang (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches. |
| FILED | Wednesday, July 29, 2015 |
| APPL NO | 15/329683 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) C07H 21/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/10 (20130101) C12N 15/1065 (20130101) Original (OR) Class C12N 15/1093 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6806 (20130101) C12Q 1/6816 (20130101) C12Q 1/6816 (20130101) C12Q 1/6816 (20130101) C12Q 1/6837 (20130101) C12Q 1/6841 (20130101) C12Q 1/6869 (20130101) C12Q 2521/107 (20130101) C12Q 2525/143 (20130101) C12Q 2525/161 (20130101) C12Q 2525/161 (20130101) C12Q 2525/179 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2537/143 (20130101) C12Q 2563/179 (20130101) C12Q 2563/179 (20130101) C12Q 2565/102 (20130101) C12Q 2565/514 (20130101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 30/00 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098313 | Williams |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nature Technology Corporation (Lincoln, Nebraska) |
| ASSIGNEE(S) | NATURE TECHNOLOGY CORPORATION (Lincoln, Nebraska) |
| INVENTOR(S) | James A. Williams (Lincoln, Nebraska) |
| ABSTRACT | The present invention relates to the production and use of covalently closed circular (ccc) recombinant DNA molecules such as plasmids, cosmids, bacterial artificial chromosomes (BACs), bacteriophages, viral vectors and hybrids thereof, and more particularly to vector modifications that improve expression of said DNA molecules. |
| FILED | Friday, June 29, 2018 |
| APPL NO | 16/022881 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/64 (20130101) C12N 15/67 (20130101) C12N 15/79 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 2800/24 (20130101) C12N 2800/107 (20130101) C12N 2820/55 (20130101) C12N 2830/42 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) C12P 21/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098326 | Joung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Shengdar Tsai (Charlestown, Massachusetts) |
| ABSTRACT | Many studies have shown that CRISPR-Cas nucleases can tolerate up to five mismatches and still cleave; it is hard to predict the effects of any given single or combination of mismatches on activity. Taken together, these nucleases can show significant off-target effects but it can be challenging to predict these sites. Described herein are methods for increasing the specificity of genome editing using the CRISPR/Cas system, e.g., using RNA-guided FokI Nucleases (RFNs), e.g., FokI-Cas9 or FokI-dCas9-based fusion proteins. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 16/751578 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 2319/00 (20130101) C07K 2319/01 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/22 (20130101) C12N 9/0071 (20130101) C12N 9/96 (20130101) C12N 9/1007 (20130101) C12N 15/01 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/1031 (20130101) C12N 2310/20 (20170501) C12N 2710/00033 (20130101) C12N 2770/00033 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 114/11 (20130101) C12Y 201/01 (20130101) C12Y 301/00 (20130101) C12Y 301/21004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098336 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Michelle C. Y. Chang (Berkeley, California); Jorge A. Marchand Benmaman (Berkeley, California); Monica E. Neugebauer (Berkeley, California) |
| ABSTRACT | Recombinant enzymes BesA, BesB, BesC, BesD and/or BesE are used generate non-canonical amino acids comprising a useful functional group, such as an alkynlyl, alkenyl or halogen. |
| FILED | Sunday, October 13, 2019 |
| APPL NO | 16/600502 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098342 | Simon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Matthew Simon (New Haven, Connecticut); Jeremy Schofield (New Haven, Connecticut) |
| ABSTRACT | The invention provides methods and compositions for generating mutations in new nucleic acid molecules through incorporation of a transformable nucleoside into the nucleic acid and subsequent transformation of the nucleoside through oxidative-nucleophilic-aromatic-substitution chemistry, referred to as TimeLapse chemistry. The invention further provides methods for detecting the mutations, referred to as TimeLapse-seq. |
| FILED | Friday, March 30, 2018 |
| APPL NO | 15/941323 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098349 | Driebe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Translational Genomics Research Institute (Phoenix, Arizona); Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona) |
| ASSIGNEE(S) | The Translational Genomics Research Institute (Phoenix, Arizona); Arizona Board of Regents on behalf of Northern Arizona University (Flagstaff, Arizona) |
| INVENTOR(S) | Elizabeth Driebe (Flagstaff, Arizona); Jolene Bowers (Flagstaff, Arizona); David Engelthaler (Flagstaff, Arizona); Paul Keim (Flagstaff, Arizona) |
| ABSTRACT | Embodiments of the invention include methods of identifying microorganisms and/or diagnosing infections in subjects cause by microorganisms. Embodiments of the invention may also include further characterizing (e.g., determining the presence of one or more antibiotic resistance markers) the microorganisms and determining a strain identity of the microorganisms. |
| FILED | Thursday, November 03, 2016 |
| APPL NO | 15/773270 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/689 (20130101) C12Q 2600/16 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098350 | Quake et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Stephen R. Quake (Stanford, California); Thomas M. Snyder (Palo Alto, California); Hannah Valantine (Stanford, California) |
| ABSTRACT | The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant. |
| FILED | Friday, March 22, 2019 |
| APPL NO | 16/361752 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6837 (20130101) C12Q 1/6869 (20130101) C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098353 | Ju et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Jingyue Ju (Englewood Cliffs, New Jersey); Dae Hyun Kim (Northbrook, Illinois); Lanrong Bi (Hancock, Michigan); Qinglin Meng (Foster City, California); Xiaoxu Li (New York, New York) |
| ABSTRACT | This invention provides a process for sequencing single-stranded DNA employing modified nucleotides. |
| FILED | Friday, December 20, 2019 |
| APPL NO | 16/722702 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) C12Q 1/6823 (20130101) C12Q 1/6869 (20130101) Original (OR) Class C12Q 1/6869 (20130101) C12Q 2523/107 (20130101) C12Q 2523/107 (20130101) C12Q 2523/319 (20130101) C12Q 2523/319 (20130101) C12Q 2565/631 (20130101) C12Q 2565/631 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098359 | Salk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| INVENTOR(S) | Jesse Salk (Seattle, Washington); Lawrence A. Loeb (Bellevue, Washington); Michael Schmitt (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Thursday, August 30, 2018 |
| APPL NO | 16/118290 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class C12Q 2525/179 (20130101) C12Q 2525/185 (20130101) C12Q 2525/191 (20130101) C12Q 2525/191 (20130101) C12Q 2535/119 (20130101) C12Q 2535/119 (20130101) C12Q 2535/122 (20130101) C12Q 2563/179 (20130101) C12Q 2565/514 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098361 | Murphy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| INVENTOR(S) | Barbara Murphy (Pelham Manor, New York); John Cijiang He (Forest Hills, New York) |
| ABSTRACT | A method for identifying the risk of developing Chronic Allograft Nephropathy (CAN) in a patient that received a kidney transplant from a donor which comprises identifying the race of the donor; determining the levels of SHROOM 3 expression in a kidney biopsy specimen obtained from the patient at a predetermined time after transplant; comparing the level of SHROOM 3 expression in the biopsy specimen with the levels of SHROOM 3 expression in a control; determining if the level of SHROOM 3 expression in the allograft is significantly higher than in the control, and diagnosing the patient as being at risk for CAN if the level of SHROOM 3 expression in the specimen is significantly higher than in the control. |
| FILED | Monday, March 10, 2014 |
| APPL NO | 14/773687 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2500/10 (20130101) G01N 2800/50 (20130101) G01N 2800/245 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098367 | Santin |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Alessandro Santin (Orange, Connecticut) |
| ABSTRACT | The invention includes a method of determining whether a mammal's cancerous tumor is associated with a hypermutator phenotype (i.e., harboring a large number of mutations) for the DNA Polymerase epsilon (POLE) gene as compared to normal cells. The invention further includes a method of selecting patients harboring an immunogenic tumor that is responsive to immunotherapy. |
| FILED | Monday, January 26, 2015 |
| APPL NO | 15/113339 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098369 | Barbie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | David Barbie (Andover, Massachusetts); Russell W. Jenkins (Boston, Massachusetts); Cloud P. Paweletz (Boston, Massachusetts); Elena Ivanova (Brookline, Massachusetts); Amir Aref (Malden, Massachusetts) |
| ABSTRACT | Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted. |
| FILED | Friday, August 17, 2018 |
| APPL NO | 15/999230 |
| ART UNIT | 1634 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/04 (20130101) C12N 9/6491 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) C12Q 1/6881 (20130101) C12Q 1/6886 (20130101) Original (OR) Class Enzymes C12Y 304/24007 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 33/5082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099004 | Lessner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Susan M. Lessner (Newberry, South Carolina); Liya Du (Columbia, South Carolina) |
| ABSTRACT | A method of marking a hydrated tissue specimen for mechanical testing is provided. The method includes adding a metal nanoparticle precursor solution to a reducing agent solution to form a mixture; incubating the mixture to form a plurality of aggregated metal nanoparticles, where each of the aggregated metal nanoparticles includes a plurality of individual metal nanoparticles; separating the plurality of aggregated metal nanoparticles from a supernatant by means of centrifugation or gravitational settling; resuspending the plurality of aggregated metal nanoparticles in a buffer solution to form a colloidal metal nanoparticle suspension; and soaking the hydrated tissue specimen in the colloidal metal nanoparticle suspension, where at least a portion of the plurality of aggregated metal nanoparticles adhere to the hydrated tissue specimen in a random pattern of speckles. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 16/598107 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/16 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 1/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099172 | Akassoglou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone (San Francisco, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The J. David Gladstone Insitutes (San Francisco, California); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Katerina Akassoglou (San Francisco, California); Michelle Arkin (San Francisco, California); Kean-Hooi Ang (San Francisco, California); Anke Meyer-Franke (San Francisco, California); Christopher Wilson (San Francisco, California) |
| ABSTRACT | The present invention provides cell-based assays, including high throughput cell-based assays, for identification of candidate therapeutic agents with the ability to inhibit microglial activation in vivo in response to different ligands. |
| FILED | Monday, April 02, 2018 |
| APPL NO | 15/943474 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/502 (20130101) G01N 33/5008 (20130101) G01N 33/5014 (20130101) G01N 33/5044 (20130101) G01N 33/5047 (20130101) G01N 33/5058 (20130101) Original (OR) Class G01N 2500/00 (20130101) G01N 2800/28 (20130101) G01N 2800/7095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099177 | Levinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| INVENTOR(S) | Nicholas Mark Levinson (Minneapolis, Minnesota); Emily Ruff (Winona, Minnesota); Joseph M. Muretta (Minneapolis, Minnesota); David D. Thomas (Minneapolis, Minnesota); Eric Lake (Minneapolis, Minnesota) |
| ABSTRACT | A protein kinase that includes a donor molecule and an acceptor molecule, methods of making the protein kinase, and methods of using the protein kinase are described. Measurement of the conformation of the kinase can be obtained using intramolecular FRET. The protein kinase can be used to, for example, identify conformational changes involved in kinase regulation, that is, as an allostery sensor; to identify kinase-binding molecules including, for example, kinase inhibitors; to identify cancer therapeutics; or for high-throughput screening. |
| FILED | Friday, September 08, 2017 |
| APPL NO | 16/331335 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Enzymes C12Y 207/11001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/542 (20130101) Original (OR) Class G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099401 | Olson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| INVENTOR(S) | Jonathan D. Olson (Hanover, New Hampshire); Keith D. Paulsen (Hanover, New Hampshire); David W. Roberts (Lyme, New Hampshire) |
| ABSTRACT | A birefringent spectral demultiplexer for hyperspectral imaging includes N birefringent beamsplitting stages arranged along a light propagation path, to produce 2N mutually divergent output light beams. Each of the output light beams differs from every other one of the output light beams in polarization and/or spectral bandwidth. Each birefringent beamsplitting stage includes a retarder for modifying polarization of each light beam received by the birefringent beamsplitting stage, and a Wollaston prism for splitting each light beam into two orthogonally polarized and divergent light beams. The Wollaston prism has a beamsplitting interface arranged at an oblique angle to the light propagation path. The oblique angle of the beamsplitting interface of each Wollaston prism of the series, except for the first one, is smaller than the oblique angle of the beamsplitting interface of each preceding Wollaston prism. The demultiplexer may be configured to accept input light of any polarization. |
| FILED | Monday, June 17, 2019 |
| APPL NO | 16/443519 |
| ART UNIT | 2878 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/201 (20130101) G02B 27/42 (20130101) G02B 27/285 (20130101) Original (OR) Class G02B 27/4205 (20130101) Pictorial Communication, e.g Television H04N 5/332 (20130101) H04N 5/2254 (20130101) H04N 2005/2255 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11100685 | Liang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Jianming Liang (Scottsdale, Arizona); Nima Tajbakhsh (Los Angeles, California); Jaeyul Shin (Chandler, Arizona) |
| ABSTRACT | Detecting a pulmonary embolism (PE) in an image dataset of a blood vessel involves obtaining a volume of interest (VOI) in the blood vessel, generating a plurality of PE candidates within the VOI, generating a set of voxels for each PE candidate, estimating for each PE candidate an orientation of the blood vessel that contains the PE candidate, given the set of voxels for the PE candidate, and generating a visualization of the blood vessel that contains the PE candidate using the estimated orientation of the blood vessel that contains the PE candidate. |
| FILED | Thursday, August 29, 2019 |
| APPL NO | 16/556135 |
| ART UNIT | 2619 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0263 (20130101) A61B 6/5217 (20130101) A61B 8/5223 (20130101) Image Data Processing or Generation, in General G06T 11/008 (20130101) Original (OR) Class G06T 19/20 (20130101) G06T 2210/41 (20130101) G06T 2211/404 (20130101) G06T 2219/028 (20130101) G06T 2219/2004 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101021 | Nadkarni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| ASSIGNEE(S) | Icahn School of Medicine at Mount Sinai (New York, New York) |
| INVENTOR(S) | Girish Nadkarni (New York, New York); Omri Gottesman (New York, New York); Stephen Bartlett Ellis (Long Island City, New York); Erwin Bottinger (New Rochelle, New York) |
| ABSTRACT | An example method of diagnosing chronic kidney disease (CKD) includes obtaining an electronic medical record for a patient having medical data. The medical data includes an indication if the patient had been previously diagnosed with CKD, an indication if the patient had previously undergone a kidney transplant, an indication if the patient had previously undergone a renal dialysis procedure, an indication if the patient had previously been diagnosed with another type of kidney disease, one or more glomerular filtration rate (GFR) measurements associated with the patient, an indication if the patient has type 2 diabetes, and/or an indication if the patient has hypertension. The method also includes automatically determining that the patient has CKD or does not have CKD based on the medical data in the electronic record. |
| FILED | Friday, July 31, 2015 |
| APPL NO | 15/502243 |
| ART UNIT | 3686 — Business Methods - Incentive Programs, Coupons; Electronic Shopping; Business Cryptography, Voting; Health Care; Point of Sale, Inventory, Accounting; Business Processing, Electronic Negotiation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/201 (20130101) A61B 5/7275 (20130101) A61B 2218/00 (20130101) Electric Digital Data Processing G06F 19/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) Original (OR) Class G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 11097090 | Vasilyev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Nikolay V. Vasilyev (Newton, Massachusetts); Pedro J. del Nido (Lexington, Massachusetts); Tonatiuh M. Lievano Beltran (Cuernavaca, Mexico); Erik A. Kraus (Hillsborough, North Carolina); Nikhil Mehandru (Roslyn, New York); Evelyn J. Park (Rolling Hills Estates, California); Conor J. Walsh (Cambridge, Massachusetts); Isaac Wamala (Jamaica Plain, Massachusetts); Markus Horvath (Cambridge, Massachusetts) |
| ABSTRACT | Methods and apparatuses relate to an implantable device for providing contractile assistance to an organ. The device may include an actuator and anchors located on either side of the actuator. The anchors engage with oppositely positioned tissue walls of an organ chamber, and provide contractile assistance to the organ, repeatedly, at appropriate times. For example, the device may be implanted within the right ventricle, anchored to the right ventricular free wall and the ventricular septum. The device may function to bring the opposing walls of the ventricle toward one another, synchronized with the pacing of the heart, resulting in an improved ejection fraction of blood from the chamber. In some embodiments, the actuator includes a bladder that is configured to contract upon receiving an inflow of pressurized fluid therein. When the fluid exits therefrom, the bladder relaxes back to an initial, extended state. |
| FILED | Wednesday, March 28, 2018 |
| APPL NO | 15/938680 |
| ART UNIT | 3792 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/283 (20210101) A61B 17/0401 (20130101) A61B 2017/00243 (20130101) A61B 2017/0404 (20130101) A61B 2017/0417 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 60/40 (20210101) A61M 60/50 (20210101) A61M 60/122 (20210101) A61M 60/148 (20210101) Original (OR) Class A61M 60/187 (20210101) A61M 60/268 (20210101) A61M 60/857 (20210101) A61M 2205/32 (20130101) A61M 2205/33 (20130101) A61M 2205/0283 (20130101) A61M 2205/3303 (20130101) A61M 2230/04 (20130101) A61M 2230/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097122 | Lu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Daniel C. Lu (Los Angeles, California) |
| ABSTRACT | In various embodiments methods and devices are provided for facilitating locomotor function and/or voiding of bladder and/or bowel in a subject with a neuromotor disorder. In certain embodiments the methods involve providing magnetic stimulation of the spinal cord at a location, frequency and intensity sufficient to facilitate locomotor function and/or voiding of bladder and/or bowel. |
| FILED | Friday, November 04, 2016 |
| APPL NO | 15/344381 |
| ART UNIT | 3791 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36017 (20130101) A61N 1/36034 (20170801) A61N 2/02 (20130101) A61N 2/004 (20130101) A61N 2/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097261 | Landers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Combat Capabilities Development Command, Chemical Biological Center (APG, Maryland) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | John M. Landers (Riverton, New Jersey); Christopher J Karwacki (Churchville, Maryland); Trenton M Tovar (Parkville, Maryland); Gregory W Peterson (Bel Air, Maryland) |
| ABSTRACT | The present invention relates to single thread composite fibers comprising at least one binder and at least one active catalyst for the capture and degradation of chemical threats such as chemical warfare agents (CWA), biological warfare agents, and toxic industrial chemicals (TIC) and a method for producing the same. The invention fibers are applicable to the fields of protective garments, filtration materials, and decontamination materials. |
| FILED | Friday, April 12, 2019 |
| APPL NO | 16/382373 |
| ART UNIT | 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemical Means for Extinguishing Fires or for Combating or Protecting Against Harmful Chemical Agents; Chemical Materials for Use in Breathing Apparatus A62D 3/30 (20130101) A62D 2101/02 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/066 (20130101) B01J 35/06 (20130101) Original (OR) Class B01J 35/1004 (20130101) B01J 35/1052 (20130101) B01J 37/0009 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097464 | Matusik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Wojciech Matusik (Lexington, Massachusetts); Wenshou Wang (Quincy, Massachusetts); Kiril Vidimce (Cambridge, Massachusetts); Javier Ramos (Boston, Massachusetts) |
| ABSTRACT | Devices and methods are described that provide printing of three-dimensional objects using reactive materials such as materials that result in a polyurethane formulation. Three-dimensional printing in accordance with the present disclosure can be performed using an inkjet printer or other systems that deposit or dispense material. A formulation made up of two or more reactive materials and, optionally, one or more UV-curable materials is also provided. The materials can be jetted based on a desired configuration to achieve a maximum reaction between materials, and can be based on desired jetting or molar ratios. By heating or applying energy on the jetted materials, their reaction and related solidifying can be accelerated. Corrective printing is also provided for, and can be used at desired intervals to eliminate printing errors relative to the object as modeled. Systems and methods used in conjunction with all of the same are provided. |
| FILED | Friday, August 25, 2017 |
| APPL NO | 15/687211 |
| ART UNIT | 1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/307 (20170801) B29C 64/393 (20170801) B29C 67/246 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/00 (20130101) B29K 2105/0002 (20130101) B29K 2105/0005 (20130101) B29K 2105/005 (20130101) B29K 2105/0011 (20130101) B29K 2105/0014 (20130101) B29K 2105/0032 (20130101) B29K 2105/0047 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) B33Y 70/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/244 (20130101) C08G 18/1825 (20130101) C08G 18/3203 (20130101) C08G 18/3206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097995 | Davis |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Matthew C. Davis (Ridgecrest, California) |
| ABSTRACT | A method of making fuel including adding alcohol to a reactor with a zinc dihalide salt and heating the reactor to reflux, thereby forming a mixture. Water is removed from the mixture using azeotropic distillation. The mixture is distilled, thereby forming oligo(alkenes)n and residual alcohol. The oligo(alkenes)n are distilled using fractionation, thereby forming a first, a second, a third fraction, and removing the residual alcohol. The first fraction includes oligo(alkenes)n with n ranging from 2 to 4, the second fraction includes oligo(alkenes)n with n ranging from 4 to 8, and the third fraction includes oligo(alkenes)n with n ranging from 8 to 12. The first, second, and third fractions are hydrogenated, thereby forming oligo(alkanes)n. The first fraction includes oligo(alkanes)n with n ranging from 2 to 4, the second fraction includes oligo(alkanes)n with n ranging from 4 to 8, and the third fraction includes oligo(alkanes)n with n ranging from 8 to 12. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 16/876338 |
| ART UNIT | 1772 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 1/24 (20130101) Original (OR) Class C07C 1/045 (20130101) C07C 5/03 (20130101) C07C 7/06 (20130101) C07C 9/06 (20130101) C07C 9/08 (20130101) C07C 9/10 (20130101) C07C 9/14 (20130101) C07C 11/02 (20130101) C07C 2523/42 (20130101) C07C 2523/44 (20130101) C07C 2523/46 (20130101) C07C 2523/755 (20130101) C07C 2527/138 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098088 | Lightfoot et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| INVENTOR(S) | Yaima L. Lightfoot (Washington, District of Columbia); Bikash Sahay (Gainesville, Florida); Mansour Mohamadzadeh (Gainesville, Florida) |
| ABSTRACT | The current invention provides a recombinant bacterium, the recombinant bacterium being genetically modified to decrease or eliminate the display of lipoteichoic acid (LTA), surface layer protein B (SlpB) and surface layer protein X (SlpX) on the surface of said bacterium. Efficacious therapies for a subject suffering from an inflammation mediated disease are also provided. The methods of the current invention comprise administering to a subject in need thereof a therapeutically effective amount of the recombinant L. acidophilus cells or a therapeutically effective amount of the isolated surface layer protein A (SlpA) or a non-naturally occurring derivative thereof. The recombinant L. acidophilus cells or SlpA isolated from L. acidophilus can be in a pharmaceutical composition comprising a pharmaceutically acceptable carrier and/or excipient. In an embodiment of the invention, the pharmaceutical composition is administered orally. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 16/790793 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/747 (20130101) A61K 38/13 (20130101) A61K 38/164 (20130101) Peptides C07K 14/335 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/746 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098260 | Johnston et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Southwest Research Institute (San Antonio, Texas) |
| ASSIGNEE(S) | SOUTHWEST RESEARCH INSTITUTE (San Antonio, Texas) |
| INVENTOR(S) | Darrel W. Johnston (Boerne, Texas); Monica R. Medrano (San Antonio, Texas); Daniel Moreland (San Antonio, Texas); Michael MacNaughton (San Antonio, Texas); Matthew S. Blais (San Antonio, Texas); Jimell Erwin (San Antonio, Texas) |
| ABSTRACT | Technologies for combusting hazardous compounds such as chemical warfare agents and related compounds are disclosed. In embodiments, the technologies include systems and methods for combusting such compounds in an internal combustion engine, such as a spark ignition internal combustion engine, a diesel engine, or the like. The technologies described herein further include components for treating an exhaust gas stream produced by combustion of hazardous compounds. In embodiments such components include a scrubber that utilizes a scrubbing media such as soil to removing acid gases from the exhaust stream. |
| FILED | Thursday, May 23, 2019 |
| APPL NO | 16/421450 |
| ART UNIT | 3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Separation B01D 53/40 (20130101) B01D 53/75 (20130101) B01D 53/76 (20130101) B01D 53/83 (20130101) B01D 53/92 (20130101) B01D 2258/012 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/06 (20130101) C10L 1/08 (20130101) C10L 1/2222 (20130101) C10L 1/2406 (20130101) C10L 1/2633 (20130101) C10L 10/00 (20130101) Original (OR) Class C10L 2270/023 (20130101) C10L 2270/026 (20130101) Internal-combustion Piston Engines; Combustion Engines in General F02B 43/12 (20130101) Controlling Combustion Engines F02D 19/022 (20130101) F02D 19/025 (20130101) F02D 19/0623 (20130101) F02D 19/0642 (20130101) F02D 41/008 (20130101) Supplying Combustion Engines in General With Combustible Mixtures or Constituents Thereof F02M 26/15 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098261 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Evelyn N. Wang (Cambridge, Massachusetts); Daniel John Preston (Cambridge, Massachusetts) |
| ABSTRACT | Lubricant infused surfaces (LIS) can be uncoated high-surface-energy solids, thereby eliminating the need for unreliable low-surface-energy coatings and resulting in LIS repelling the lowest surface tension impinging fluid (butane, γ≈13 mN/m) reported to date. |
| FILED | Friday, November 16, 2018 |
| APPL NO | 16/194262 |
| ART UNIT | 1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Cleaning in General; Prevention of Fouling in General B08B 17/065 (20130101) Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 105/80 (20130101) Original (OR) Class C10M 171/00 (20130101) C10M 2227/04 (20130101) C10M 2227/045 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2020/093 (20200501) C10N 2050/02 (20130101) C10N 2050/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098286 | Lock et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Martin Lock (Southampton, Pennsylvania); Mauricio Alvira (Philadelphia, Pennsylvania) |
| ABSTRACT | A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates. |
| FILED | Friday, December 09, 2016 |
| APPL NO | 16/060405 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Separation B01D 15/166 (20130101) B01D 15/363 (20130101) B01D 15/3804 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/281 (20130101) B01J 41/05 (20170101) B01J 41/20 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/02 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/8645 (20130101) C12N 2750/14143 (20130101) C12N 2750/14151 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098305 | Chaikind et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | Zymergen Inc. (Emeryville, California) |
| INVENTOR(S) | Brian Chaikind (Oakland, California); Hendrik Marinus van Rossum (Oakland, California) |
| ABSTRACT | Methods, compositions, and kits for high throughput DNA assembly reactions in vitro. Modular CRISPR DNA constructs comprising modular insert DNA parts flanked by cloning tag segments comprising pre-validated CRISPR protospacer/protospacer adjacent motif sequence combinations. |
| FILED | Thursday, August 08, 2019 |
| APPL NO | 16/535245 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/66 (20130101) C12N 15/1003 (20130101) C12N 2310/20 (20170501) C12N 2310/3517 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098307 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Michael David Lynch (Durham, North Carolina); Ashley Trahan (Hillsborough, North Carolina); Daniel Rodriguez (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina); Charles Cooper (Durham, North Carolina); Ahmet Bozdag (Durham, North Carolina) |
| ABSTRACT | This invention relates to metabolically engineered microorganisms, such as bacterial and or fungal strains, and bioprocesses utilizing such strains. These strains enable the dynamic control of metabolic pathways, which can be used to optimize production. Dynamic control over metabolism is accomplished via a combination of methodologies including but not limited to transcriptional silencing and controlled enzyme proteolysis. These microbial strains are utilized in a multi-stage bioprocess encompassing at least two stages, the first stage in which microorganisms are grown and metabolism can be optimized for microbial growth and at least one other stage in which growth can be slowed or stopped, and dynamic changes can be made to metabolism to improve the production of desired product, such as a chemical or fuel. |
| FILED | Wednesday, April 15, 2020 |
| APPL NO | 16/849455 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2320/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098346 | Bishop et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Joshua Bishop (Seattle, Washington); Joshua Buser (Seattle, Washington); Samantha Byrnes (Seattle, Washington); Shivani Dharmaraja (Seattle, Washington); Elain S. Fu (Seattle, Washington); Jared Houghtaling (Seattle, Washington); Peter C. Kauffman (Seattle, Washington); Sujatha Kumar (Seattle, Washington); Lisa Lafleur (Seattle, Washington); Tinny Liang (Seattle, Washington); Barry Lutz (Seattle, Washington); Bhushan Toley (Seattle, Washington); Maxwell Wheeler (Seattle, Washington); Paul Yager (Seattle, Washington); Xiaohong Zhang (Seattle, Washington) |
| ABSTRACT | The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage. |
| FILED | Thursday, August 09, 2018 |
| APPL NO | 16/059919 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 7/00 (20130101) B01L 7/52 (20130101) B01L 2200/0605 (20130101) B01L 2300/044 (20130101) B01L 2300/069 (20130101) B01L 2300/126 (20130101) B01L 2300/0672 (20130101) B01L 2300/0816 (20130101) B01L 2300/0825 (20130101) B01L 2300/0864 (20130101) B01L 2300/0867 (20130101) B01L 2300/0887 (20130101) B01L 2300/1827 (20130101) B01L 2300/1855 (20130101) B01L 2300/1877 (20130101) B01L 2400/0406 (20130101) B01L 2400/0622 (20130101) B01L 2400/0672 (20130101) B01L 2400/0683 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 436/2575 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098399 | Paulino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United Technologies Corporation (Hartford, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Jose R. Paulino (Saco, Maine); Christopher W. Strock (Kennebunk, Maine) |
| ABSTRACT | A gas turbine engine article includes a substrate and a bond coating that covers at least a portion of the substrate with a step formed in at least one of the substrate and the bond coating. A thermally insulating topcoat is disposed on the bond coating. The thermally insulating topcoat includes a first topcoat portion separated by at least one fault that extends through the thermally insulating topcoat from a second topcoat portion. |
| FILED | Wednesday, July 29, 2015 |
| APPL NO | 14/812668 |
| ART UNIT | 3745 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/12 (20130101) Original (OR) Class Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/122 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2230/90 (20130101) F05D 2240/11 (20130101) F05D 2300/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098677 | Stambaugh |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | HAMILTON SUNDSTRAND CORPORATION (Charlotte, North Carolina) |
| INVENTOR(S) | Craig T. Stambaugh (Tolland, Connecticut) |
| ABSTRACT | This disclosure relates to a variable area nozzle of a gas turbine engine. The variable area nozzle includes, among other things, a control unit, a translatable structure, and a plurality of actuators configured to adjust the position of the translatable structure. The plurality of actuators are fluidly coupled to a common fluid source. The control unit is configured to provide instructions to at least one of the actuators to compensate for an asymmetric load from the translatable structure. |
| FILED | Tuesday, February 27, 2018 |
| APPL NO | 15/906234 |
| ART UNIT | 3752 — Fluid Handling and Dispensing |
| CURRENT CPC | Jet-propulsion Plants F02K 1/15 (20130101) F02K 1/76 (20130101) F02K 1/763 (20130101) F02K 1/1223 (20130101) Original (OR) Class F02K 3/10 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2250/73 (20130101) F05D 2270/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098707 | van Boeyen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lynntech, Inc. (College Station, Texas) |
| ASSIGNEE(S) | Lynntech, Inc. (College Station, Texas) |
| INVENTOR(S) | Roger W. van Boeyen (Bryan, Texas); Jonathan A. Reeh (College Station, Texas); Mehmet Kesmez (College Station, Texas); Eric A. Heselmeyer (College Station, Texas); Jeffrey S. Parkey (College Station, Texas) |
| ABSTRACT | An electrochemically actuated pump and an electrochemical actuator for use with a pump. The pump includes one of various stroke volume multiplier configuration with the pressure of a pumping fluid assisting actuation of a driving fluid bellows. The electrochemical actuator has at least one electrode fluidically coupled to the driving fluid chamber of the first pump housing and at least one electrode fluidically coupled to the driving fluid chamber of the second pump housing. Accordingly, the electrochemical actuator selectively pressurized hydrogen gas within a driving fluid chamber. |
| FILED | Tuesday, June 11, 2019 |
| APPL NO | 16/438250 |
| ART UNIT | 3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 19/24 (20130101) F04B 43/10 (20130101) F04B 43/107 (20130101) F04B 43/1133 (20130101) F04B 43/1136 (20130101) F04B 45/02 (20130101) Original (OR) Class F04B 45/022 (20130101) F04B 45/024 (20130101) F04B 45/053 (20130101) F04B 45/0336 (20130101) F04B 49/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098784 | Daily et al. |
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| FUNDED BY |
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| APPLICANT(S) | David J Daily (Middletown, Rhode Island); Jesse L Belden (Barrington, Rhode Island); Aren M Hellum (Wakefield, Rhode Island); David N Beal (Providence, Rhode Island); Andrew N Guarendi (East Greenwich, Rhode Island) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (, None) |
| INVENTOR(S) | David J Daily (Middletown, Rhode Island); Jesse L Belden (Barrington, Rhode Island); Aren M Hellum (Wakefield, Rhode Island); David N Beal (Providence, Rhode Island); Andrew N Guarendi (East Greenwich, Rhode Island) |
| ABSTRACT | A shock mitigator is provided for mitigating physical shock to a joined object. The shock mitigator includes a hollow body capable of being affixed to the object and having two ends defining a volume therein. A cavitating liquid is disposed in the hollow body volume. At least one end cap is slidingly disposed within the hollow body to seal at least one end thereof. When exposed to a physical shock the cavitating liquid changes phase from a liquid to a vapor, absorbing energy from the shock. |
| FILED | Monday, April 10, 2017 |
| APPL NO | 15/483345 |
| ART UNIT | 3732 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Springs; Shock-absorbers; Means for Damping Vibration F16F 9/006 (20130101) F16F 9/36 (20130101) F16F 9/3207 (20130101) F16F 9/5126 (20130101) Original (OR) Class F16F 2222/12 (20130101) F16F 2230/12 (20130101) F16F 2230/30 (20130101) F16F 2232/08 (20130101) F16F 2234/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099000 | Mohseni et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Hooman Mohseni (Wilmette, Illinois); Vala Fathipour (Berkeley, California) |
| ABSTRACT | Systems for coherent light detection are provided, including a system comprising a light source configured to generate light; a first optical assembly configured to split the light into a reference arm and a sample arm; a second optical assembly configured to illuminate a sample with light of the sample arm, thereby generating a sample signal; a third optical assembly configured to combine the sample signal with light of the reference arm, thereby generating an interference signal; and a detector assembly comprising an array of carrier injection photodetectors, the array arranged to collect the interference signal. Methods of using the systems are also provided. |
| FILED | Friday, April 13, 2018 |
| APPL NO | 16/605659 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0066 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02004 (20130101) G01B 9/02091 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/109 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099077 | Stammer et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Clinton F. Stammer (Camarillo, California); David A. Sisemore (Oxnard, California); Jack Ronald White (Camarillo, California) |
| ABSTRACT | A background subtracted spectrometer for airborne infrared radiometry. The background subtracted spectrometer may comprise: a filter array, a detector, and a dewar containing liquid nitrogen. The filter array may be configured to selectively pass different spectral bands of infrared radiation. The filter array may comprise: at least one linear variable filter and a plurality of bandpass filters. The detector may comprise a focal plane array configured to receive the different spectral bands of infrared radiation simultaneously transmitted through the filter array. The detector may generate one or more electrical signals indicative of infrared radiation intensity as a function of wavelength. The filter array may be coupled to the focal plane array of the detector, and the filter array and detector may be conductively cooled by the liquid nitrogen to improve signal-to-noise ratio and spectral measurements. The background subtracted spectrometer preferably lacks a circular variable filter and relay lens. |
| FILED | Tuesday, June 04, 2019 |
| APPL NO | 16/430555 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/108 (20130101) G01J 3/0205 (20130101) G01J 5/602 (20130101) Original (OR) Class G01J 2005/604 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/14649 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099103 | Skalny et al. |
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| FUNDED BY |
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| APPLICANT(S) | U.S. GOVERNMENT AS REPRESENTED BY THE SECRETARY OF THE ARMY (Washington, District of Columbia) |
| ASSIGNEE(S) | Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | David A. Skalny (Shelby Township, Michigan); John M. Zwally (Canton, Michigan); Tyruss J. Valascho (Clarkston, Michigan); Matthew W. Skalny (Shelby Township, Michigan); Craig W. Schmehl (Royal Oak, Michigan) |
| ABSTRACT | One example is test system for testing the propulsion system(s) of vehicles. The test system includes a retention fixture, a linking device, a test logic, a measurement device and a result logic. The retention fixture is for rigidly mounting first and second vehicles to the retention fixture. The linking device links propulsion systems of the first and second vehicles so that the propulsion systems operate a different rates. The test logic subjects the second vehicle's propulsion system to a propulsion test. The measurement device measures at least one parameter associated with the propulsion system of the first vehicle while the first vehicle is subjected to the propulsion test. The result logic determines if the first vehicle under test passed the propulsion test based, in part, on the at least one parameter and generates an indication if the first vehicle passed or failed the propulsion test. |
| FILED | Tuesday, February 26, 2019 |
| APPL NO | 16/285507 |
| ART UNIT | 2856 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 5/13 (20130101) G01L 5/0042 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 13/023 (20130101) G01M 17/0074 (20130101) Original (OR) Class G01M 99/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099129 | Weber et al. |
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| FUNDED BY |
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| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | Brown University (Providence, Rhode Island) |
| INVENTOR(S) | Peter M. Weber (Barrington, Rhode Island); Fedor Rudakov (Cambridge, Massachusetts) |
| ABSTRACT | A system includes a first laser beam including a pulsed laser emanating from the instrument propagates in the air, wherein the first lase beam is tuned to the wavelength at which a target chemical absorbs, its pulses bringing molecules to an excited state, a second laser beam used to probe target chemicals by transient absorption spectroscopy, wherein the second laser beam is pulsed or continuous, and a detector. |
| FILED | Friday, September 14, 2018 |
| APPL NO | 16/647382 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/39 (20130101) Original (OR) Class G01N 2021/392 (20130101) G01N 2021/396 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099165 | Rubenstein |
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| FUNDED BY |
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| APPLICANT(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | H. Mitchell Rubenstein (Beavercreek, Ohio) |
| ABSTRACT | A method for reducing the variability, as measured by relative standard deviation (RSD), of an analytical testing technique is provided. This improvement in RSD improves the confidence in the values obtained during field testing. The method includes incorporating a focusing agent into the sampling media, which permits providing sampling media such as thermal desorption tubes preloaded with the focusing agent. |
| FILED | Tuesday, March 07, 2017 |
| APPL NO | 15/451438 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Separation B01D 53/025 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/405 (20130101) G01N 30/08 (20130101) G01N 30/7206 (20130101) G01N 30/8668 (20130101) G01N 33/0006 (20130101) G01N 33/0057 (20130101) Original (OR) Class G01N 2030/025 (20130101) G01N 2030/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099340 | Stone |
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| FUNDED BY |
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| APPLICANT(S) | Wavefront Research, Inc. (Northampton, Pennsylvania) |
| ASSIGNEE(S) | Wavefront Research, Inc. (Northhampton, Pennsylvania) |
| INVENTOR(S) | Thomas W. Stone (Hellertown, Pennsylvania) |
| ABSTRACT | Methods and systems for optical interconnection. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 16/780425 |
| ART UNIT | 2874 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/04 (20130101) G02B 6/06 (20130101) G02B 6/32 (20130101) G02B 6/262 (20130101) G02B 6/327 (20130101) G02B 6/403 (20130101) G02B 6/423 (20130101) G02B 6/4249 (20130101) G02B 6/4292 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11100223 | Thrasher et al. |
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| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Carl J. Thrasher (Beavercreek, Ohio); Christopher E. Tabor (Kettering, Ohio); Zachary J. Farrell (Xenia, Ohio); Nicholas J. Morris (Dayton, Ohio) |
| ABSTRACT | The present invention relates to core shell liquid metal encapsulates comprising multi-functional ligands, networks comprising such encapsulates and processes of making and using such encapsulates and networks. When subjected to strain, such network's conductivity is enhanced, thus allowing the network to serve as a healing agent that restores at least a portion of the conductivity in an adjacent conductor. |
| FILED | Tuesday, September 24, 2019 |
| APPL NO | 16/580601 |
| ART UNIT | 1761 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Electric Digital Data Processing G06F 21/554 (20130101) Original (OR) Class G06F 21/556 (20130101) G06F 21/755 (20170801) G06F 2221/034 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/08 (20130101) H01B 1/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11100389 | Niggemeyer et al. |
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| FUNDED BY |
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| APPLICANT(S) | ELECTRONIC WARFARE ASSOCIATES, INC. (Herndon, Virginia) |
| ASSIGNEE(S) | ELECTRONIC WARFARE ASSOCIATES, INC. (Herndon, Virginia) |
| INVENTOR(S) | Dirk Niggemeyer (Shrewsbury, Massachusetts); Lester A. Foster, III (Frederick, Maryland) |
| ABSTRACT | A digital signal may be converted into a spiking analog signal. A different constant current may be applied to each of a plurality of switch circuits. Each bit of the digital signal may be applied to a corresponding one of the plurality of switch circuits. Each switch circuit may apply the corresponding constant current to a common output when the corresponding bit has a predetermined value. Each switch circuit may not apply the corresponding constant current to the common output when the corresponding bit does not have the predetermined value. A common current may be applied at the common output to a spiking neuron circuit. |
| FILED | Monday, November 05, 2018 |
| APPL NO | 16/180999 |
| ART UNIT | 2845 — Electrical Circuits and Systems |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/049 (20130101) Original (OR) Class Coding; Decoding; Code Conversion in General H03M 1/66 (20130101) H03M 1/745 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11100396 | Ozcan et al. |
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| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| INVENTOR(S) | Ahmet S. Ozcan (San Jose, California); J. Campbell Scott (San Jose, California) |
| ABSTRACT | Self-adjusting thresholds for synaptic activity in neural networks are provided. In various embodiments, for each of a plurality of neurons within an artificial neural network, an overlap value is determined corresponding to active inputs connected to the neuron via synapses having non-zero synaptic weights. A count of those of the plurality of neurons whose overlap exceeds an activation threshold of the neural network is determined. The count is compared to a predetermined neuronal activity target. The activation threshold of the neural network is adjusted to approach the predetermined neuronal activity target. |
| FILED | Thursday, August 24, 2017 |
| APPL NO | 15/685152 |
| ART UNIT | 2125 — AI & Simulation/Modeling |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) G06N 3/082 (20130101) Original (OR) Class G06N 3/088 (20130101) G06N 3/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11100419 | Moodera et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jagadeesh S. Moodera (Somerville, Massachusetts); Patrick A. Lee (Brookline, Massachusetts); Peng Wei (Riverside, California); Sujit Manna (New Delhi, India) |
| ABSTRACT | Under certain conditions, a fermion in a superconductor can separate in space into two parts known as Majorana zero modes, which are immune to decoherence from local noise sources and are attractive building blocks for quantum computers. Here we disclose a metal-based heterostructure platform to produce these Majorana zero modes which utilizes the surface states of certain metals in combination with a ferromagnetic insulator and a superconductor. This platform has the advantage of having a robust energy scale and the possibility of realizing complex circuit designs using lithographic methods. The Majorana zero modes are interrogated using planar tunnel junctions and electrostatic gates to selectively tunnel into designated pairs of Majorana zero modes. We give example of qubit designs and circuits that are particularly suitable for the metal-based heterostructures. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 16/867601 |
| ART UNIT | 2896 — AI & Simulation/Modeling |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/18 (20130101) H01L 29/0673 (20130101) H01L 39/08 (20130101) H01L 39/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11100658 | Muhleman |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Daniel H. Muhleman (El Cajon, California) |
| ABSTRACT | Method comprises receiving, by at least one memory, from at least one imaging system, at least two input images. The method includes comparing, by a processor, the at least two input images to each other such that nonstationary portions of the at least two input images are determined by either separating, by the at least one processor, each of the two input images into multiple pixel regions, and generating an error matrix for each of said multiple pixel regions. If an error value in the error matrix falls within a predetermined range, the pixel region is a nonstationary portion of the input images; or identifying, by a machine learning system, nonstationary portions of the input images. The pixels from nonstationary portions are removed from the at least two input images. |
| FILED | Friday, January 10, 2020 |
| APPL NO | 16/739351 |
| ART UNIT | 2661 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/32 (20170101) Original (OR) Class G06T 7/97 (20170101) G06T 2207/10032 (20130101) G06T 2207/20081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101120 | Chaudhary et al. |
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| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Ashish Chaudhary (Safety Harbor, Florida); Robert Timothy Short (St. Petersburg, Florida) |
| ABSTRACT | The disclosure includes an ionization chamber, a first electron multiplier, and a second electron multiplier. The ionization chamber is configured to receive gas molecules from an environment at a pressure. The first electron multiplier is configured to receive a plurality of photons from a photon source, generate a first plurality of electrons from the plurality of photons, and discharge the first plurality of electrons into the ionization chamber to generate a plurality of gas ions from at least a portion of the gas molecules. The second electron multiplier is configured to receive the plurality of gas ions from the ionization chamber and generate a second plurality of electrons from the plurality of gas ions that is proportional to a quantity of the plurality of gas ions. A quantity of electrons of the second plurality of electrons is indicative of the pressure. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 16/664389 |
| ART UNIT | 2867 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 9/0072 (20130101) G01L 19/0007 (20130101) G01L 21/12 (20130101) G01L 21/30 (20130101) G01L 21/32 (20130101) G01L 21/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/64 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 41/02 (20130101) Original (OR) Class H01J 41/04 (20130101) H01J 41/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101379 | Romanczyk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | THEREGENIS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Brian Romanczyk (Santa Barbara, California); Haoran Li (Goleta, California); Elaheh Ahmadi (Hyattsville, Maryland); Steven Wienecke (Santa Barabara, California); Matthew Guidry (Goleta, California); Xun Zheng (Santa Barbara, California); Stacia Keller (Santa Barbara, California); Umesh K. Mishra (Montecito, California) |
| ABSTRACT | A novel design for a nitrogen polar high-electron-mobility transistor (HEMT) structure comprising a GaN/InGaN composite channel. As A novel design for a nitrogen polar high-electron-mobility transistor (HEMT) structure comprising a GaN/InGaN composite channel. As illustrated herein, a thin InGaN layer introduced in the channel increases the carrier density, reduces the electric field in the channel, and increases the carrier mobility. The dependence of p on InGaN thickness (tInGaN) and indium composition (xIn) was investigated for different channel thicknesses. With optimized tInGaN and xIn, significant improvements in electron mobility were observed. For a 6 nm channel HEMT, the electron mobility increased from 606 to 1141 cm2/(V·s) when the 6 nm thick pure GaN channel was replaced by the 4 nm GaN/2 nm In0.1Ga0.9N composite channel. |
| FILED | Thursday, November 16, 2017 |
| APPL NO | 16/461505 |
| ART UNIT | 2892 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/205 (20130101) H01L 29/1029 (20130101) H01L 29/2003 (20130101) H01L 29/7786 (20130101) Original (OR) Class H01L 29/66462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101616 | Rakich et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Peter Rakich (New Haven, Connecticut); Nils Thomas Otterstrom (New Haven, Connecticut); Eric Andrew Kittlaus (New Haven, Connecticut); Ryan Orson Behunin (Flagstaff, Arizona); Zheng Barton Wang (Austin, Texas) |
| ABSTRACT | Techniques for producing a Brillouin laser are provided. According to some aspects, techniques are based on forward Brillouin scattering and a multimode acousto-optic waveguide in which light is scattered between optical modes of the waveguide via the Brillouin scattering. This process may transfer energy from a waveguide mode of pump light to a waveguide mode of Stokes light. This process may be referred to herein as Stimulated Inter-Modal Brillouin Scattering (SIMS). Since SIMS is based on forward Brillouin scattering, laser (Stokes) light may be output in a different direction than back toward the input pump light, and as such there is no need for a circulator or other non-reciprocal device to protect the pump light as in conventional devices. |
| FILED | Friday, May 11, 2018 |
| APPL NO | 15/977500 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/07 (20130101) H01S 3/30 (20130101) Original (OR) Class H01S 3/063 (20130101) H01S 3/083 (20130101) H01S 3/0632 (20130101) H01S 3/0804 (20130101) H01S 3/1068 (20130101) H01S 3/1086 (20130101) H01S 3/08045 (20130101) H01S 3/094049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101809 | Roper |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Christopher S. Roper (Oak Park, California) |
| ABSTRACT | Some variations provide a metal vapor-density control system comprising: a first electrode; a multiphase second electrode that is electrically isolated from the first electrode, wherein the second electrode contains an ion-conducting phase capable of transporting mobile ions and an atom-transporting phase capable of storing and transporting neutral forms of the mobile ions; and an ion-conducting layer interposed between the first electrode and the second electrode, wherein the ion-conducting layer is capable of transporting the mobile ions. The metal vapor-density control system may be contained within a vapor cell, a cold atom system, an atom chip, an atom gyroscope, an atomic clock, a communication system switch or buffer, a single-photon generator or detector, a gas-phase atom sensor, a nonlinear frequency generator, a precision spectroscopy instrument, an accelerometer, a gyroscope, an atom interferometer, a magneto-optical trap, an atomic-cloud imaging apparatus, or an atom dispenser system, for example. |
| FILED | Thursday, June 11, 2020 |
| APPL NO | 16/898519 |
| ART UNIT | 2849 — Electrical Circuits and Systems |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/62 (20130101) Time-interval Measuring G04F 5/145 (20130101) Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101915 | Anlage et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, COLLEGE PARK (College Park, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland) |
| INVENTOR(S) | Steven Mark Anlage (Laurel, Maryland); Frank Cangialosi (Ellicott City, Maryland); Tyler Grover (St. Leonard, Maryland); Andrew Simon (Gaithersburg, Maryland); Scott Roman (Reisterstown, Maryland); Liangcheng Tao (Plano, Texas) |
| ABSTRACT | The subject method for delivering power to a moving target wirelessly via electromagnetic time reversal can find applications in wireless electrical transmission to portable devices, wireless heating of portable devices, novel wirelessly powered accelerometers, hyperthermic treatment of cancers, and many other applications. The subject non-linear time reversed electromagnetic waves based wireless power transmission (WPT) system targets either a single linear or non-linear object where a selective targeting between two diodes has been demonstrated simultaneously with different degrees of non-linearity in a three-dimensional ray-chaotic billiard model. A dual-purpose rectenna with harmonic generation for wireless power transfer by non-linear time-reversal has been designed for the subject system using the Schottky diode. |
| FILED | Tuesday, April 25, 2017 |
| APPL NO | 16/096430 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/20 (20160201) H02J 50/23 (20160201) H02J 50/90 (20160201) Transmission H04B 11/00 (20130101) Secret Communication; Jamming of Communication H04K 1/00 (20130101) H04K 1/06 (20130101) Original (OR) Class H04K 3/62 (20130101) H04K 3/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11102181 | Salo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Timothy J. Salo (Saint Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy J. Salo (Saint Paul, Minnesota) |
| ABSTRACT | A method and apparatus where network-layer devices use host-provided, detailed, per-packet, semantic information (DPPS information), which describes the content, meaning, importance, and/or other attributes of particular application data and is associated with each packet, to provide enhanced network services. In some embodiments of the above method, network-layer devices use DPPS information that includes QoS-related information to provide fine-grained, content-aware, and/or complex QoS assurances or similar services. In some embodiments, network-layer devices use DPPS information to provide network-based, application-protocol-independent, rate-adaptation services. In some embodiments, network-layer devices use DPPS information to provide highly efficient, application-protocol-independent, publish/subscribe dissemination services. |
| FILED | Tuesday, May 29, 2018 |
| APPL NO | 15/992135 |
| ART UNIT | 2458 — Computer Networks |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/14 (20130101) H04L 45/306 (20130101) H04L 45/308 (20130101) H04L 47/24 (20130101) H04L 47/32 (20130101) H04L 47/805 (20130101) H04L 47/806 (20130101) H04L 47/2441 (20130101) H04L 63/06 (20130101) H04L 63/0428 (20130101) Original (OR) Class H04L 67/32 (20130101) H04L 67/327 (20130101) H04L 67/2804 (20130101) H04L 69/22 (20130101) H04L 69/321 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11102200 | Burnett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Architecture Technology Corporation (Minneapolis, Minnesota) |
| ASSIGNEE(S) | ARCHITECTURE TECHNOLOGY CORPORATION (Minneapolis, Minnesota) |
| INVENTOR(S) | Benjamin L. Burnett (Prior Lake, Minnesota); Ranga Ramanujan (Medina, Minnesota) |
| ABSTRACT | In general, the techniques of this disclosure describe a computing device that is configured to verify an identity of a user based on authentication factors received from multiple authentication devices. The computing device, which may be configured to operate as a server device, may receive an authentication factor from at least three authentication devices in a group of three or more authentication devices via a guard device. The computing device may determine a probability that the respective user of each respective authentication device is a particular trusted user based on the received authentication factors. If the probability exceeds a threshold authentication probability, the computing device may send an authentication confirmation to a client device. |
| FILED | Friday, January 12, 2018 |
| APPL NO | 15/870492 |
| ART UNIT | 2431 — Cryptography and Security |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00892 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/083 (20130101) H04L 63/0853 (20130101) Original (OR) Class H04L 63/0861 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11102873 | Valestin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| ASSIGNEE(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| INVENTOR(S) | Jason J. Valestin (Cedar Rapids, Iowa); Clifford R. Klein (Marion, Iowa); Michael J. Nielsen (North Liberty, Iowa) |
| ABSTRACT | A system and related method provide an ability at a local level to develop and modify an aircraft lighting configuration. Local maintenance may modify and replace a lighting configuration file associated with an aircraft lighting control defining default values and preset intensities for interior, exterior, cabin, and cargo bay lighting. A Graphical User Interface (GUI) offers a maintenance technician and a crewmember efficient flight deck control of each zone and field enabling efficient user control of each aspect of aircraft lighting. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 16/502468 |
| ART UNIT | 2145 — Graphical User Interface and Document Processing |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 45/00 (20130101) B64D 47/06 (20130101) B64D 2045/0085 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 5/60 (20170101) Electric Digital Data Processing G06F 3/0482 (20130101) G06F 3/04817 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 47/155 (20200101) H05B 47/175 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11102883 | Thrasher et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Air Force (WPAFB, Ohio) |
| INVENTOR(S) | Carl J. Thrasher (Huber Heights, Ohio); Christopher E. Tabor (Kettering, Ohio); Zachary J. Farrell (Xenia, Ohio); Nicholas J. Morris (Dayton, Ohio) |
| ABSTRACT | The present invention relates to substrates comprising a network comprising core shell liquid metal encapsulates comprising multi-functional ligands and processes of making and using such substrates. The core shell liquid metal particles are linked via ligands to form such network. Such networks volumetric conductivity increases under strain which maintains a substrate's resistance under strain. The constant resistance results in consistent thermal heating via resistive heating. Thus allowing a substrate that comprises such network to serve as an effective heat provider. |
| FILED | Friday, November 01, 2019 |
| APPL NO | 16/671708 |
| ART UNIT | 1761 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/09 (20130101) H05K 1/0283 (20130101) Original (OR) Class H05K 3/10 (20130101) H05K 3/22 (20130101) H05K 2201/0245 (20130101) H05K 2201/0314 (20130101) H05K 2203/0783 (20130101) H05K 2203/1105 (20130101) H05K 2203/1131 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US D928689 | Seeley |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Eric Seeley (Seabeck, Washington) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Eric Seeley (Seabeck, Washington) |
| ABSTRACT | |
| FILED | Thursday, October 03, 2019 |
| APPL NO | 29/742034 |
| ART UNIT | 2917 — Design |
| CURRENT CPC | Transportation D12/308 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US D928690 | Guild et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (Keyport, Washington) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Jennifer A Guild (Poulsbo, Washington); Eric E Seeley (Seabeck, Washington); Jose M Ruiz (Bremerton, Washington); Logan Harris (Tacoma, Washington) |
| ABSTRACT | |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 29/742129 |
| ART UNIT | 2917 — Design |
| CURRENT CPC | Transportation D12/308 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US D928691 | Guild et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (Keyport, Washington) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Jennifer A Guild (Poulsbo, Washington); Eric E Seeley (Seabeck, Washington); Jose M Ruiz (Bremerton, Washington) |
| ABSTRACT | |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 29/742133 |
| ART UNIT | 2917 — Design |
| CURRENT CPC | Transportation D12/308 |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US D928903 | Carson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Government as Represented by the Secretary of the Army (Dover, New Jersey) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Robert Carson (Watervliet, New York); David Marshall (Ballston Lake, New York); Tyler Bellamy (Cropseyville, New York); Scott Bentley (Cohoes, New York) |
| ABSTRACT | |
| FILED | Thursday, February 28, 2019 |
| APPL NO | 29/681822 |
| ART UNIT | 2922 — Design |
| CURRENT CPC | Arms, pyrotechnics, hunting and fishing equipment D22/108 |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 11096772 | MacEwan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Matthew R. MacEwan (St. Louis, Missouri); Jingwei Xie (Chesapeake, Ohio); Zack Ray (St. Louis, Missouri); Younan Xia (Atlanta, Georgia) |
| ABSTRACT | A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229171 |
| ART UNIT | 3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/02 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/22 (20130101) A61L 15/42 (20130101) A61L 27/14 (20130101) A61L 27/50 (20130101) Apparatus for Enzymology or Microbiology; C12M 25/14 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0076 (20130101) D01D 5/0092 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/728 (20130101) D04H 3/016 (20130101) D04H 3/073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096854 | Kazerooni et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ekso Bionics, Inc. (Richmond, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Ekso Bionics, Inc. (Richmond, California); The Regents of the University of California (Berkeley, California) |
| INVENTOR(S) | Homayoon Kazerooni (Oakland, California); Katherine Strausser (Berkeley, California); Adam Zoss (Berkeley, California); Tim Swift (Albany, California) |
| ABSTRACT | A system and method by which movements desired by a user of a lower extremity orthotic is determined and a control system automatically regulates the sequential operation of powered lower extremity orthotic components to enable the user, having mobility disorders, to walk, as well as perform other common mobility tasks which involve leg movements, perhaps with the use of a gait aid. |
| FILED | Monday, October 30, 2017 |
| APPL NO | 15/797060 |
| ART UNIT | 3785 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/00 (20130101) Original (OR) Class A61H 1/024 (20130101) A61H 1/0244 (20130101) A61H 3/00 (20130101) A61H 3/02 (20130101) A61H 2201/165 (20130101) A61H 2201/1215 (20130101) A61H 2201/1616 (20130101) A61H 2201/1642 (20130101) A61H 2201/5007 (20130101) A61H 2201/5028 (20130101) A61H 2201/5069 (20130101) A61H 2201/5079 (20130101) A61H 2201/5084 (20130101) A61H 2201/5092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097415 | Guerin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Kelleher Guerin (Baltimore, Maryland); Gregory Hager (Baltimore, Maryland) |
| ABSTRACT | Methods and systems for connection-driven generation of robotic user interfaces and modification of robotic properties include detecting a connection of a robotic peripheral to a robot; obtaining a peripheral property set corresponding to the robotic peripheral, wherein the peripheral property set includes one or more properties of the robotic peripheral; modifying, based on the peripheral property set, a robotic property set that includes one or more properties of the robot to provide a modified robotic property set; generating, during runtime, a robotic graphical user interface (“RGUI”) dynamically based on the peripheral property set, wherein the RGUI provides at least one user-accessible interface to control the robot and the robotic peripheral; and controlling, based on the modified robotic property set, the robot and the robotic peripheral in response to user input received via the RGUI. |
| FILED | Wednesday, July 24, 2019 |
| APPL NO | 16/520873 |
| ART UNIT | 3664 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/161 (20130101) Original (OR) Class B25J 9/1671 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/409 (20130101) G05B 2219/40095 (20130101) G05B 2219/40099 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097464 | Matusik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Wojciech Matusik (Lexington, Massachusetts); Wenshou Wang (Quincy, Massachusetts); Kiril Vidimce (Cambridge, Massachusetts); Javier Ramos (Boston, Massachusetts) |
| ABSTRACT | Devices and methods are described that provide printing of three-dimensional objects using reactive materials such as materials that result in a polyurethane formulation. Three-dimensional printing in accordance with the present disclosure can be performed using an inkjet printer or other systems that deposit or dispense material. A formulation made up of two or more reactive materials and, optionally, one or more UV-curable materials is also provided. The materials can be jetted based on a desired configuration to achieve a maximum reaction between materials, and can be based on desired jetting or molar ratios. By heating or applying energy on the jetted materials, their reaction and related solidifying can be accelerated. Corrective printing is also provided for, and can be used at desired intervals to eliminate printing errors relative to the object as modeled. Systems and methods used in conjunction with all of the same are provided. |
| FILED | Friday, August 25, 2017 |
| APPL NO | 15/687211 |
| ART UNIT | 1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/307 (20170801) B29C 64/393 (20170801) B29C 67/246 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2075/00 (20130101) B29K 2105/0002 (20130101) B29K 2105/0005 (20130101) B29K 2105/005 (20130101) B29K 2105/0011 (20130101) B29K 2105/0014 (20130101) B29K 2105/0032 (20130101) B29K 2105/0047 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) B33Y 70/00 (20141201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/244 (20130101) C08G 18/1825 (20130101) C08G 18/3203 (20130101) C08G 18/3206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098307 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Michael David Lynch (Durham, North Carolina); Ashley Trahan (Hillsborough, North Carolina); Daniel Rodriguez (Durham, North Carolina); Zhixia Ye (Raleigh, North Carolina); Charles Cooper (Durham, North Carolina); Ahmet Bozdag (Durham, North Carolina) |
| ABSTRACT | This invention relates to metabolically engineered microorganisms, such as bacterial and or fungal strains, and bioprocesses utilizing such strains. These strains enable the dynamic control of metabolic pathways, which can be used to optimize production. Dynamic control over metabolism is accomplished via a combination of methodologies including but not limited to transcriptional silencing and controlled enzyme proteolysis. These microbial strains are utilized in a multi-stage bioprocess encompassing at least two stages, the first stage in which microorganisms are grown and metabolism can be optimized for microbial growth and at least one other stage in which growth can be slowed or stopped, and dynamic changes can be made to metabolism to improve the production of desired product, such as a chemical or fuel. |
| FILED | Wednesday, April 15, 2020 |
| APPL NO | 16/849455 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2320/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098999 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | University of Rochester (Rochester, New York) |
| INVENTOR(S) | Di Xu (Beijing, China PRC); Jannick Rolland-Thompson (Seneca Falls, New York) |
| ABSTRACT | A cascaded interferometric system for Fourier domain optical coherence tomography (OCT) in which the output of one sub-system interferometer is directed through a second sub-system interferometer for performing the Fourier transform in hardware. |
| FILED | Friday, December 14, 2018 |
| APPL NO | 16/220321 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0066 (20130101) A61B 5/0073 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02015 (20130101) G01B 9/02043 (20130101) G01B 9/02091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099004 | Lessner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Susan M. Lessner (Newberry, South Carolina); Liya Du (Columbia, South Carolina) |
| ABSTRACT | A method of marking a hydrated tissue specimen for mechanical testing is provided. The method includes adding a metal nanoparticle precursor solution to a reducing agent solution to form a mixture; incubating the mixture to form a plurality of aggregated metal nanoparticles, where each of the aggregated metal nanoparticles includes a plurality of individual metal nanoparticles; separating the plurality of aggregated metal nanoparticles from a supernatant by means of centrifugation or gravitational settling; resuspending the plurality of aggregated metal nanoparticles in a buffer solution to form a colloidal metal nanoparticle suspension; and soaking the hydrated tissue specimen in the colloidal metal nanoparticle suspension, where at least a portion of the plurality of aggregated metal nanoparticles adhere to the hydrated tissue specimen in a random pattern of speckles. |
| FILED | Thursday, October 10, 2019 |
| APPL NO | 16/598107 |
| ART UNIT | 1798 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/16 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 1/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099076 | Alemán et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Oregon (Eugene, Oregon) |
| ASSIGNEE(S) | University of Oregon (Eugene, Oregon) |
| INVENTOR(S) | Benjamin J. Alemán (Eugene, Oregon); Andrew D. Blaikie (Eugene, Oregon); David J. Miller (Eugene, Oregon) |
| ABSTRACT | A thermo-mechanical resonating microbolometer has a graphene absorber suspended above a metallic silicon substrate to form a mechanical resonator. Microelectronic circuitry electrically connected to the graphene resonator and the metallic silicon substrate drives electronically the motion of the graphene absorber. Shifts in the mechanical resonant frequency of the graphene layer due to the absorption of incident radiation is measured electronically or using optical interferometry. A bolometer sensor array may be fabricated using such graphene microbolometer elements. |
| FILED | Friday, March 08, 2019 |
| APPL NO | 16/297384 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/20 (20130101) Original (OR) Class G01J 5/023 (20130101) G01J 2005/202 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099136 | Agarwal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Kriti Agarwal (Uttar Pradesh, India); Chunhui Dai (Minneapolis, Minnesota); Jeong-Hyun Cho (Woodbury, Minnesota) |
| ABSTRACT | 3D graphene optical sensors, such as microstructure sensors and nanostructure sensors. The 3D optical sensors include one or more graphene panels shaped to surround an interior, open volume. Graphene plasmons couple across the interior, open volume. The 3D optical sensors can have a polygonal shape or a cylindrical shape. |
| FILED | Friday, December 21, 2018 |
| APPL NO | 16/229919 |
| ART UNIT | 2886 — Optics |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/182 (20170801) C01B 32/194 (20170801) C01B 2204/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/554 (20130101) G01N 21/8806 (20130101) G01N 21/9009 (20130101) Original (OR) Class G01N 21/9036 (20130101) G01N 2021/869 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099210 | Echols-Jones et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRUSTEES OF TUFTS COLLEGE (Medford, Massachusetts) |
| ASSIGNEE(S) | Trustees of Tufts College (Medford, Massachusetts) |
| INVENTOR(S) | Piers Echols-Jones (Medford, Massachusetts); William C. Messner (Amesbury, Massachusetts); Igor Sokolov (Medford, Massachusetts) |
| ABSTRACT | A method of carrying out sub-resonant tapping in an atomic force microscope includes causing a probe that is disposed above a sample to be translated in a direction parallel to a horizontal plane defined by the sample and to oscillate in a vertical direction that is perpendicular to the horizontal plane about an equilibrium line that is separated from the horizontal plane by a vertical offset. As a result, the probe repeatedly taps a surface of the sample. Each tap begins with a first contact of the probe on the surface followed by a progressive increase in force exerted by the sample on the probe until a peak force is attained. The vertical offset is controlled by relying at least in part on a feature other than the peak force as a basis for controlling the vertical offset. |
| FILED | Tuesday, January 30, 2018 |
| APPL NO | 16/481759 |
| ART UNIT | 2881 — Optics |
| CURRENT CPC | Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 10/02 (20130101) G01Q 10/065 (20130101) G01Q 60/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099281 | Berlin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Joseph Nathaniel Berlin (Coatesville, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Nathaniel Berlin (Coatesville, Pennsylvania) |
| ABSTRACT | A method and device for measuring the magnetic rigidity of penetrating charged particles uses an elongated transparent ionizable medium, surrounded by a reflective interface, extending along a helical path around a longitudinal axis. A magnet applies a magnetic field to the medium in a direction along the longitudinal axis. A single luminosity proportional photon detector is operationally associated with the medium and adapted to generate signals indicative of the number of photons transiting the medium. A controller is adapted to receive the signals and calculate a penetration depth of the ionizing particle through the medium based on the number of photons transiting the medium and a magnetic rigidity of the charged particle based upon the penetration depth. |
| FILED | Monday, March 09, 2020 |
| APPL NO | 16/812591 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/2006 (20130101) Original (OR) Class G01T 1/2042 (20130101) G01T 5/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099591 | Köse et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Selçuk Köse (Tampa, Florida); Longfei Wang (Tampa, Florida); S. Karen Khatamifard (Los Angeles, California); Ulya R. Karpuzcu (Minneapolis, Minnesota) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| INVENTOR(S) | Selçuk Köse (Tampa, Florida); Longfei Wang (Tampa, Florida); S. Karen Khatamifard (Los Angeles, California); Ulya R. Karpuzcu (Minneapolis, Minnesota) |
| ABSTRACT | A DLDO has a configuration that mitigates performance degradation associated with limit cycle oscillation (LCO). The DLDO comprises a clocked comparator, an array of power transistors, a digital controller and a clock pulsewidth reduction circuit. The digital controller comprises control logic configured to generate control signals that cause the power transistors to be turned ON or OFF in accordance with a preselected activation/deactivation control scheme. The clock pulsewidth reduction circuit receives an input clock signal having a first pulsewidth and generates the DLDO clock signal having the preselected pulsewidth that is narrower that the first pulsewidth, which is then delivered to the clock terminals of the clocked comparator and the digital controller. The narrower pulsewidth of the DLDO clock reduces the LCO mode to mitigate performance degradation caused by LCO. |
| FILED | Wednesday, September 11, 2019 |
| APPL NO | 16/567858 |
| ART UNIT | 2838 — Electrical Circuits and Systems |
| CURRENT CPC | Systems for Regulating Electric or Magnetic Variables G05F 1/56 (20130101) G05F 1/59 (20130101) Original (OR) Class G05F 1/563 (20130101) G05F 1/565 (20130101) G05F 1/575 (20130101) G05F 1/614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11100419 | Moodera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jagadeesh S. Moodera (Somerville, Massachusetts); Patrick A. Lee (Brookline, Massachusetts); Peng Wei (Riverside, California); Sujit Manna (New Delhi, India) |
| ABSTRACT | Under certain conditions, a fermion in a superconductor can separate in space into two parts known as Majorana zero modes, which are immune to decoherence from local noise sources and are attractive building blocks for quantum computers. Here we disclose a metal-based heterostructure platform to produce these Majorana zero modes which utilizes the surface states of certain metals in combination with a ferromagnetic insulator and a superconductor. This platform has the advantage of having a robust energy scale and the possibility of realizing complex circuit designs using lithographic methods. The Majorana zero modes are interrogated using planar tunnel junctions and electrostatic gates to selectively tunnel into designated pairs of Majorana zero modes. We give example of qubit designs and circuits that are particularly suitable for the metal-based heterostructures. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 16/867601 |
| ART UNIT | 2896 — AI & Simulation/Modeling |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/18 (20130101) H01L 29/0673 (20130101) H01L 39/08 (20130101) H01L 39/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11100791 | Guerin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Kelleher Guerin (Baltimore, Maryland); Gregory Hager (Baltimore, Maryland) |
| ABSTRACT | Provided is a method, device, and computer-readable medium for controlling a robot graphic user interface (“RGUI”) on a mobile device. The method can include determining a distance, a position, or both of the mobile device with respect to a first robot; and causing, by a processor, a first RGUI to be displayed on a display of the mobile device based on the determining. |
| FILED | Tuesday, April 21, 2020 |
| APPL NO | 16/854779 |
| ART UNIT | 3664 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/409 (20130101) G05B 2219/39384 (20130101) G05B 2219/40382 (20130101) Transmission Systems for Measured Values, Control or Similar Signals G08C 17/02 (20130101) Original (OR) Class G08C 2201/20 (20130101) G08C 2201/30 (20130101) G08C 2201/70 (20130101) G08C 2201/91 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101616 | Rakich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Peter Rakich (New Haven, Connecticut); Nils Thomas Otterstrom (New Haven, Connecticut); Eric Andrew Kittlaus (New Haven, Connecticut); Ryan Orson Behunin (Flagstaff, Arizona); Zheng Barton Wang (Austin, Texas) |
| ABSTRACT | Techniques for producing a Brillouin laser are provided. According to some aspects, techniques are based on forward Brillouin scattering and a multimode acousto-optic waveguide in which light is scattered between optical modes of the waveguide via the Brillouin scattering. This process may transfer energy from a waveguide mode of pump light to a waveguide mode of Stokes light. This process may be referred to herein as Stimulated Inter-Modal Brillouin Scattering (SIMS). Since SIMS is based on forward Brillouin scattering, laser (Stokes) light may be output in a different direction than back toward the input pump light, and as such there is no need for a circulator or other non-reciprocal device to protect the pump light as in conventional devices. |
| FILED | Friday, May 11, 2018 |
| APPL NO | 15/977500 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/07 (20130101) H01S 3/30 (20130101) Original (OR) Class H01S 3/063 (20130101) H01S 3/083 (20130101) H01S 3/0632 (20130101) H01S 3/0804 (20130101) H01S 3/1068 (20130101) H01S 3/1086 (20130101) H01S 3/08045 (20130101) H01S 3/094049 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US RE48704 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| INVENTOR(S) | Brian L. Anderson (Lodi, California); Bill W. Colston (San Ramon, California); Christopher J. Elkin (Cranston, Rhode Island) |
| ABSTRACT | A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample. |
| FILED | Tuesday, August 28, 2018 |
| APPL NO | 16/115187 |
| ART UNIT | 3991 — Central Reexamination Unit (Chemical) |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 1/6844 (20130101) C12Q 2531/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 11096636 | Kross et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (Newport News, Virginia) |
| ASSIGNEE(S) | JEFFERSON SCIENCE ASSOCIATES, LLC (Newport News, Virginia) |
| INVENTOR(S) | Brian Kross (Yorktown, Virginia); Andrew Weisenberger (Yorktown, Virginia); Ben Welch (Hampton, Virginia); David Gilland (Gainesville, Florida); Seung Joon Lee (Poquoson, Virginia) |
| ABSTRACT | A nuclear imaging system and method for performing three-dimensional imaging of anatomical structures. The system and method includes two or more gamma ray detectors each used in combination with a variable-slant hole collimator. The detectors are positioned in close proximity to, or in contact with, the structure being imaged. The detectors remain in a stationary position during the data collection process. An imaging or reconstruction method is then used to reconstruct a three-dimensional image from the data derived from the detectors. |
| FILED | Friday, June 21, 2019 |
| APPL NO | 16/448911 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/06 (20130101) A61B 6/12 (20130101) Original (OR) Class A61B 6/502 (20130101) A61B 6/4258 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097227 | Frayne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Via Separations, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | Via Separations, Inc. (Watertown, Massachusetts) |
| INVENTOR(S) | Stephen Frayne (Watertown, Massachusetts); Michelle Macleod (Somerville, Massachusetts); Brandon Ian MacDonald (Melrose, Massachusetts); Lymaris Ortiz Rivera (Cambridge, Massachusetts); Brent Keller (Somerville, Massachusetts) |
| ABSTRACT | Embodiments described herein relate generally to durable graphene oxide membranes for fluid filtration. For example, the graphene oxide membranes can be durable under high temperatures non-neutral pH, and/or high pressures. One aspect of the present disclosure relates to a filtration apparatus comprising: a support substrate, and a graphene oxide membrane disposed on the support substrate. The graphene oxide membrane has a first lactose rejection rate of at least 50% with a first 1 wt % lactose solution at room temperature. The graphene oxide membrane has a second lactose rejection rate of at least 50% with a second 1 wt % lactose solution at room temperature after the graphene oxide membrane is contacted with a solution that is at least 80° C. for a period of time. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 16/887555 |
| ART UNIT | 1779 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Separation B01D 67/0069 (20130101) B01D 67/0093 (20130101) B01D 69/10 (20130101) B01D 71/021 (20130101) Original (OR) Class B01D 2323/36 (20130101) B01D 2325/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097473 | Chesser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Phillip C. Chesser (Knoxville, Tennessee); Brian K. Post (Knoxville, Tennessee); Matthew R. Sallas (Knoxville, Tennessee); Alex C. Roschli (Kingston, Tennessee); Randall F. Lind (Loudon, Tennessee); Lonnie J. Love (Knoxville, Tennessee) |
| ABSTRACT | An additive manufacturing method that includes an extruder providing a supply of working material and a nozzle connected with respect to the extruder, the nozzle directing the working material to a deposit surface. A diverter valve is positioned between the extruder and the nozzle to direct the working material to an exhaust port away from the deposit surface under certain conditions. |
| FILED | Thursday, August 09, 2018 |
| APPL NO | 16/059896 |
| ART UNIT | 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/106 (20170801) B29C 64/209 (20170801) Original (OR) Class B29C 64/321 (20170801) B29C 64/357 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098257 | Hafenstine et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | Glenn Richard Hafenstine (Wheat Ridge, Colorado); Derek Richard Vardon (Lakewood, Colorado); Xiangchen Huo (Golden, Colorado); Nabila Asem Huq (Boulder, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes a first oxide having a phosphate, a ratio of Brønsted acid sites to Lewis acid sites between 0.05 and 1.00, and a total acidity between 50 μmol/g and 300 μmol/g, where the phosphate is at least one of a functional group covalently bonded to the first oxide and/or an anion ionically bonded to the first oxide. |
| FILED | Tuesday, May 12, 2020 |
| APPL NO | 15/930205 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/44 (20130101) B01J 27/195 (20130101) B01J 27/1802 (20130101) B01J 35/023 (20130101) B01J 35/026 (20130101) B01J 35/1014 (20130101) B01J 35/1019 (20130101) B01J 35/1038 (20130101) B01J 35/1042 (20130101) Acyclic or Carbocyclic Compounds C07C 41/09 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/02 (20130101) C10L 1/023 (20130101) C10L 1/026 (20130101) Original (OR) Class C10L 2200/0423 (20130101) C10L 2200/0446 (20130101) C10L 2270/023 (20130101) C10L 2270/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098306 | Singh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | Seema Singh (Clarksburg, Maryland); Arul Mozhy Varman (Chandler, Arizona) |
| ABSTRACT | The present invention relates to synthetic promoters, as well as expression cassettes, and recombinant scaffolds, and methods thereof. In particular embodiments, the synthetic promoter is inducible by one or more chemical compounds present during lignin depolymerization. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 16/711146 |
| ART UNIT | 1652 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/70 (20130101) C12N 2840/002 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099526 | Wenzel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Johnson Controls Technology Company (Auburn Hills, Michigan) |
| ASSIGNEE(S) | Johnson Controls Technologoy Company (Auburn Hills, Michigan) |
| INVENTOR(S) | Michael J. Wenzel (Oak Creek, Wisconsin); Kirk H. Drees (Cedarburg, Wisconsin) |
| ABSTRACT | A cascaded control system is configured to control power consumption of a building during a demand limiting period. The cascaded control system includes an energy use setpoint generator and a feedback controller. The energy use setpoint generator is configured to use energy pricing data and measurements of a variable condition within the building to generate an energy use setpoint during the demand limiting period. The feedback controller is configured to use a difference between the energy use setpoint and a measured energy use to generate a control signal for building equipment that operate to affect the variable condition within the building during the demand limiting period. |
| FILED | Monday, February 25, 2019 |
| APPL NO | 16/284895 |
| ART UNIT | 2198 — Optics |
| CURRENT CPC | Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/30 (20180101) F24F 11/46 (20180101) F24F 11/62 (20180101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/021 (20130101) Original (OR) Class Systems for Controlling or Regulating Non-electric Variables G05D 23/1923 (20130101) Systems for Regulating Electric or Magnetic Variables G05F 1/66 (20130101) Electric Digital Data Processing G06F 1/3203 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0201 (20130101) G06Q 30/0202 (20130101) G06Q 30/0206 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 12/14 (20130101) H04L 12/2803 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 90/84 (20151101) Y02P 90/845 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099539 | Fuhr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Peter L. Fuhr (Oak Ridge, Tennessee); Marissa E. Morales-Rodriguez (Oak Ridge, Tennessee); Sterling S. Rooke (Crofton, Maryland) |
| ABSTRACT | Apparatus, methods, and systems implementing multi-sensor agent devices are described herein. The agent devices can each include a plurality of sensors for measuring parameters of interest to an entity such as an electric power utility. The sensors can be organized in individually-IP-addressable sensor clusters, with each sensor cluster including an associated microcontroller. The agent devices can be controlled by a control center of the entity to operate in a coordinated manner, such as to gather and transmit data regarding parameters of interest. The agent devices can be transported to desired areas for data collection by unmanned aerial systems such as drones, and the collected data can be stored in a distributed blockchain ledger. |
| FILED | Tuesday, May 07, 2019 |
| APPL NO | 16/405855 |
| ART UNIT | 2457 — Computer Networks |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/027 (20130101) B64C 2201/127 (20130101) B64C 2201/128 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 47/08 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/0423 (20130101) Original (OR) Class Electric Digital Data Processing G06F 21/602 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/166 (20130101) H04L 63/0428 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11100419 | Moodera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Jagadeesh S. Moodera (Somerville, Massachusetts); Patrick A. Lee (Brookline, Massachusetts); Peng Wei (Riverside, California); Sujit Manna (New Delhi, India) |
| ABSTRACT | Under certain conditions, a fermion in a superconductor can separate in space into two parts known as Majorana zero modes, which are immune to decoherence from local noise sources and are attractive building blocks for quantum computers. Here we disclose a metal-based heterostructure platform to produce these Majorana zero modes which utilizes the surface states of certain metals in combination with a ferromagnetic insulator and a superconductor. This platform has the advantage of having a robust energy scale and the possibility of realizing complex circuit designs using lithographic methods. The Majorana zero modes are interrogated using planar tunnel junctions and electrostatic gates to selectively tunnel into designated pairs of Majorana zero modes. We give example of qubit designs and circuits that are particularly suitable for the metal-based heterostructures. |
| FILED | Wednesday, May 06, 2020 |
| APPL NO | 16/867601 |
| ART UNIT | 2896 — AI & Simulation/Modeling |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/18 (20130101) H01L 29/0673 (20130101) H01L 39/08 (20130101) H01L 39/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11100651 | Russell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| INVENTOR(S) | John L. Russell (Albuquerque, New Mexico); Daniel E. Small (Albuquerque, New Mexico); Jon David Bradley (Albuquerque, New Mexico) |
| ABSTRACT | A system and method for intrusion detection includes an imager directed towards an object in an interior space. The imager is in data communication with a computer. The computer is arranged to process digital three-dimensional image data received from the imager and programmed to execute a change detection algorithm in response to the processed three-dimensional data to determine movement of the object. The computer generates an alarm output in response to detecting movement of the object above a predetermined threshold. The method includes providing an imager directed towards an object in an interior space; receiving Time of Flight signals by the imager; processing digital three-dimensional image data received from the imager; and executing a change detection algorithm in response to the processed three-dimensional data to determine movement of the object. |
| FILED | Thursday, August 08, 2019 |
| APPL NO | 16/535236 |
| ART UNIT | 2482 — Recording and Compression |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4802 (20130101) G01S 17/42 (20130101) G01S 17/50 (20130101) Image Data Processing or Generation, in General G06T 7/20 (20130101) Original (OR) Class G06T 7/521 (20170101) G06T 17/05 (20130101) G06T 2207/10028 (20130101) G06T 2207/10048 (20130101) G06T 2207/30232 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 13/19 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) H04N 7/183 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11100689 | Tohlen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL FEDERAL MANUFACTURING and TECHNOLOGIES, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Michael Aaron Tohlen (Lees Summit, Missouri); Mitchell Hedges Morrow (Overland Park, Kansas) |
| ABSTRACT | A computer-implemented method comprises receiving a plurality of sampled data points, each data point including a y value and a t value; defining an array of bins, each bin identified by a unique number and including histogram data for a range of y values; for each consecutive pair of data points including a current data point and a next data point, determining a corresponding one of a plurality of linear equations, each linear equation defining a line between the current data point and the next data point; for each line, determining an amount of time that the y value of the line is within the range of values for each bin from the current data point to the next data point; and adding the time to the histogram data for each bin. |
| FILED | Tuesday, June 02, 2020 |
| APPL NO | 16/889909 |
| ART UNIT | 2613 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 11/206 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101255 | Murialdo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Maxwell Murialdo (Westminster, California); Yuliya Kanarska (Livermore, California); Andrew Pascall (Livermore, California) |
| ABSTRACT | A 3D printable feedstock ink is disclosed for use in a 3D printing process where the ink is flowed through a printing nozzle. The ink may be made up of a non-conductive flowable material and a plurality of chiplets contained in the non-conductive flowable material in random orientations. The chiplets may form a plurality of percolating chiplet networks within the non-conductive flowable material as ones of the chiplets contact one another. Each one of the chiplets has a predetermined circuit characteristic which is responsive to a predetermined electrical signal, and which becomes electrically conductive when the predetermined electrical signal is applied to the ink, to thus form at least one conductive signal path through the ink. |
| FILED | Thursday, December 13, 2018 |
| APPL NO | 16/219188 |
| ART UNIT | 1761 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 25/07 (20130101) H01L 25/16 (20130101) Original (OR) Class H01L 25/50 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/16 (20130101) H05K 3/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101617 | Meade |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ayar Labs, Inc. (Emeryville, California) |
| ASSIGNEE(S) | Ayar Labs, Inc. (Santa Clara, California) |
| INVENTOR(S) | Roy Edward Meade (Oakland, California) |
| ABSTRACT | A wafer includes a number of die, with each die including electronic integrated circuits and optical devices. The wafer has a top surface and a bottom surface and a base layer. The bottom surface of the wafer corresponds to a bottom surface of the base layer. A wafer support system is attached to the top surface of the wafer. A thickness of the base layer is removed to expose a target layer within the wafer and to give the wafer a new bottom surface. A replacement handle structure is attached to the new bottom surface of the wafer. The replacement handle structure includes a first thickness region and a second thickness region. The first thickness region is positioned closest to the new bottom surface. The first thickness region is formed of an optical cladding material that mitigates optical coupling between optical devices within the die and the replacement handle structure. |
| FILED | Tuesday, July 16, 2019 |
| APPL NO | 16/513661 |
| ART UNIT | 2828 — Semiconductors/Memory |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/0006 (20130101) G02B 6/30 (20130101) G02B 6/43 (20130101) G02B 6/124 (20130101) G02B 6/136 (20130101) G02B 6/12004 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 25/075 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US RE48704 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| INVENTOR(S) | Brian L. Anderson (Lodi, California); Bill W. Colston (San Ramon, California); Christopher J. Elkin (Cranston, Rhode Island) |
| ABSTRACT | A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample. |
| FILED | Tuesday, August 28, 2018 |
| APPL NO | 16/115187 |
| ART UNIT | 3991 — Central Reexamination Unit (Chemical) |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 1/6844 (20130101) C12Q 2531/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
11097440 — Cutting mechanism for carbon nanotube yarns, tapes, sheets and polymer composites thereof
| US 11097440 | Sauti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S.A, as represented by the Administrator of the National Aeronautics and Space Administration (Washington, District of Columbia) |
| ASSIGNEE(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| INVENTOR(S) | Godfrey Sauti (Hampton, Virginia); Jae-Woo Kim (Newport News, Virginia); Emilie J. Siochi (Newport News, Virginia); John M. Gardner (Newport News, Virginia) |
| ABSTRACT | A cutting mechanism includes electrodes that are utilized to cut or score a non-conductive outer material of a filament or sheet. The electrodes contact a conductive reinforcing material of the filament or sheet to complete an electric circuit. Electric current flows through and heats the conductive material to oxidize or otherwise separate/cut the conductive material and any remaining non-conductive material. |
| FILED | Monday, November 07, 2016 |
| APPL NO | 15/530055 |
| ART UNIT | 1748 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Perforating; Punching; Cutting-out; Stamping-out; Severing by Means Other Than Cutting B26F 3/08 (20130101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/30 (20170801) B29C 64/118 (20170801) B29C 64/209 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/167 (20130101) B29K 2507/04 (20130101) B29K 2995/0005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097484 | Snyder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MADE IN SPACE, INC. (Moffett Field, California) |
| ASSIGNEE(S) | MADE IN SPACE, INC. (Moffett Field, California) |
| INVENTOR(S) | Michael P. Snyder (Jacksonville, Florida); William Brandon Kirkland (St. Augustine, Florida); Douglas Alan Marsh (Jacksonville, Florida); Patrick F. Flowers (Jacksonville, Florida) |
| ABSTRACT | A system is disclosed including a robotic arm movable about a rotational axis to at least one of move and reposition a part at least one of during part creation and after part creation in a micro-gravity environment, wherein creation is performed by at least one of a polymer-based additive manufacturing subsystem and a metallic-based additive manufacturing subsystem and a gripping device attached to the robotic arm which holds the part during at least one of part creation and after part creation. Another system and method are also disclosed. |
| FILED | Wednesday, February 13, 2019 |
| APPL NO | 16/275301 |
| ART UNIT | 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/003 (20130101) B22F 2202/09 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/25 (20170801) B29C 64/379 (20170801) Original (OR) Class B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097499 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (Washington, District of Columbia) |
| INVENTOR(S) | Jae-Woo Kim (Newport News, Virginia); Emilie J. Siochi (Newport News, Virginia); Kristopher E. Wise (Poquoson, Virginia); John W. Connell (Yorktown, Virginia); Yi Lin (Yorktown, Virginia); Russell A. Wincheski (Williamsburg, Virginia); Dennis C. Working (Norfolk, Virginia) |
| ABSTRACT | A method allows for preparation of CNT nanocomposites having improved mechanical, electrical and thermal properties. Structured carbon nanotube forms such as sheet, yarn, and tape are modified with π-conjugated conductive polymers, including polyaniline (PANT), fabricated by in-situ polymerization. The PANI modified CNT nanocomposites are subsequently post-processed to improve mechanical properties by hot press and carbonization. |
| FILED | Monday, November 04, 2019 |
| APPL NO | 16/673517 |
| ART UNIT | 1742 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/12 (20130101) B29C 70/40 (20130101) B29C 70/42 (20130101) B29C 70/543 (20130101) Original (OR) Class B29C 70/682 (20130101) B29C 70/887 (20130101) B29C 71/02 (20130101) B29C 2071/022 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098707 | van Boeyen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lynntech, Inc. (College Station, Texas) |
| ASSIGNEE(S) | Lynntech, Inc. (College Station, Texas) |
| INVENTOR(S) | Roger W. van Boeyen (Bryan, Texas); Jonathan A. Reeh (College Station, Texas); Mehmet Kesmez (College Station, Texas); Eric A. Heselmeyer (College Station, Texas); Jeffrey S. Parkey (College Station, Texas) |
| ABSTRACT | An electrochemically actuated pump and an electrochemical actuator for use with a pump. The pump includes one of various stroke volume multiplier configuration with the pressure of a pumping fluid assisting actuation of a driving fluid bellows. The electrochemical actuator has at least one electrode fluidically coupled to the driving fluid chamber of the first pump housing and at least one electrode fluidically coupled to the driving fluid chamber of the second pump housing. Accordingly, the electrochemical actuator selectively pressurized hydrogen gas within a driving fluid chamber. |
| FILED | Tuesday, June 11, 2019 |
| APPL NO | 16/438250 |
| ART UNIT | 3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 19/24 (20130101) F04B 43/10 (20130101) F04B 43/107 (20130101) F04B 43/1133 (20130101) F04B 43/1136 (20130101) F04B 45/02 (20130101) Original (OR) Class F04B 45/022 (20130101) F04B 45/024 (20130101) F04B 45/053 (20130101) F04B 45/0336 (20130101) F04B 49/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098817 | Eddleman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| INVENTOR(S) | David E. Eddleman (Cullman, Alabama); James A. Richard (Grant, Alabama) |
| ABSTRACT | A magnetically damped check valve having a non-magnetic metal sleeve and a spring-biased poppet disposed within the check valve. The spring-biased poppet is operably supported by the sleeve. A poppet guide is attached to the sleeve. The poppet includes a shaft that is slidably attached to the poppet guide. A portion of the shaft extends into the sleeve. At least one magnet is attached to the portion of the shaft that extends into the sleeve. The magnet therefore moves with the shaft as the poppet moves in response to changes in differential pressure across the check valve. The magnet produces a magnetic field. As the magnet moves within the sleeve, the magnetic field changes thereby inducing an electrical current in the sleeve which produces another magnetic field that opposes the magnetic field of the magnet thereby damping the movement of the magnet and hence, damping the movement of the poppet. |
| FILED | Tuesday, November 19, 2019 |
| APPL NO | 16/688264 |
| ART UNIT | 3753 — Fluid Handling and Dispensing |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 39/1013 (20130101) F04B 53/1082 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 15/026 (20130101) F16K 15/063 (20130101) F16K 31/08 (20130101) Original (OR) Class F16K 31/084 (20130101) F16K 31/086 (20130101) F16K 47/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11099748 | Fraction et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| INVENTOR(S) | James E. Fraction (Greenbelt, Maryland); Andrzej T. Jackowski (Greenbelt, Maryland) |
| ABSTRACT | A radiation hardened, digital to analog converter includes first and second serial communication circuits, a common bus interface configured to connect the first and second serial communication circuits to first and second digital serial communication buses, respectively, and a digital to analog converter circuit, where the first and second serial communication circuits are configured to receive data over the first and second digital serial communication buses, respectively, for use by the digital to analog converter circuit. |
| FILED | Wednesday, August 08, 2018 |
| APPL NO | 16/058458 |
| ART UNIT | 2137 — Memory Access and Control |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0619 (20130101) Original (OR) Class G06F 3/0635 (20130101) G06F 3/0683 (20130101) G06F 11/16 (20130101) G06F 2201/82 (20130101) G06F 2212/1032 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/552 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101158 | Brown et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | United States of America as represented by the Administrator of NASA (Washington, District of Columbia) |
| INVENTOR(S) | Ari D. Brown (Ellicott City, Maryland); Joseph Oxborrow (Glen Burnie, Maryland); Vilem Mikula (Washington, District of Columbia); Kevin L. Denis (Crofton, Maryland); Timothy M. Miller (Silver Spring, Maryland) |
| ABSTRACT | The disclosed subject matter relates to techniques, laminates and devices used to fabricate thin dielectric or semiconductor membranes including a handling substrate including a photoresist material on a first surface thereof, a semiconductor wafer having a circuit pattern on a first surface and a second surface to be processed and a temporary adhesive layer temporarily bonding the first surface of the semiconductor wafer to the first surface of the handling substrate including the photoresist material. |
| FILED | Wednesday, August 08, 2018 |
| APPL NO | 16/058192 |
| ART UNIT | 2897 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0273 (20130101) H01L 21/6835 (20130101) Original (OR) Class H01L 37/00 (20130101) H01L 2221/6834 (20130101) H01L 2221/68381 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101644 | Schwerman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| INVENTOR(S) | Paul W. Schwerman (Phoenix, Arizona); George M. Brown, Jr. (Peoria, Arizona); Richard L. Marshall (Glendale, Arizona) |
| ABSTRACT | Embodiments of a single event latch-up (SEL) protection circuit are provided, including: a first circuitry block coupled to a source of an input voltage a load, and digitally controlling a first switch; the first switch generates a load and senses an instantaneous load current iLoad. A second circuitry block is configured to generate an average iLoad and generate single event latch-up triggers (i.e., SEL fault detection) as a function of at least a comparison of the inst_iLoad and average iLoad; wherein this first circuitry block contains the analog based SET filtering needed to reduce false SEL triggers. A supervisor module generates on/off commands for the first switch, responsive to receiving the SEL detection in excess of a preprogrammed delay to provide the final SET filtering to prevent false SEL triggers. The first circuitry block removes the load voltage at N1 upon receiving an off command from the supervisor module. |
| FILED | Tuesday, February 19, 2019 |
| APPL NO | 16/279580 |
| ART UNIT | 2839 — Semiconductors/Memory |
| CURRENT CPC | Emergency Protective Circuit Arrangements H02H 9/025 (20130101) Original (OR) Class Pulse Technique H03K 19/00315 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 11096576 | Dave et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PlenOptika, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PlenOptika, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Shivang R. Dave (Boston, Massachusetts); Daryl Lim (Singapore, Singapore); Nicholas James Durr (Baltimore, Maryland) |
| ABSTRACT | An apparatus, and corresponding method, for determining a refractive property of an eye includes a housing with a port configured to receive an eye and also light from the eye. A tunable lens can be mounted to the housing to apply a variable focal power to the light from the eye and to pass the light along an optical path toward a wavefront sensor within the housing. The wavefront sensor can receive the light via the optical path and measure a wavefront thereof. A determination module can be configured to determine a property of the eye based on the wavefront. Embodiments can be handheld, portable, and open view, while providing objective wavefront aberrometry, subjective phoroptry, and accommodation and presbyoptic evaluation, as well as lensometry functions. |
| FILED | Tuesday, June 13, 2017 |
| APPL NO | 16/309169 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/005 (20130101) A61B 3/0008 (20130101) A61B 3/09 (20130101) A61B 3/18 (20130101) Original (OR) Class A61B 3/028 (20130101) A61B 3/0033 (20130101) A61B 3/103 (20130101) A61B 3/0285 (20130101) A61B 3/1208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11096774 | Sicotte et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ZENFLOW, INC. (San Francisco, California) |
| ASSIGNEE(S) | ZENFLOW, INC. (San Francisco, California) |
| INVENTOR(S) | Marcel Song Sicotte (San Francisco, California); Austin Michael Bly (San Clemente, California); Ben Collett-Nye (Kumeu, New Zealand); Shreya Mehta (San Francisco, California) |
| ABSTRACT | Systems, devices, and methods are provided for the delivery of an implant into the prostatic urethra. Embodiments of delivery systems can include a delivery device for insertion into the patient and a proximal control device for use in controlling release of the implant from the delivery device. |
| FILED | Thursday, June 06, 2019 |
| APPL NO | 16/433463 |
| ART UNIT | 3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3468 (20130101) A61B 2017/00274 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/042 (20130101) Original (OR) Class A61F 2/885 (20130101) A61F 2002/047 (20130101) Gearing F16H 1/06 (20130101) F16H 1/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11097484 | Snyder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MADE IN SPACE, INC. (Moffett Field, California) |
| ASSIGNEE(S) | MADE IN SPACE, INC. (Moffett Field, California) |
| INVENTOR(S) | Michael P. Snyder (Jacksonville, Florida); William Brandon Kirkland (St. Augustine, Florida); Douglas Alan Marsh (Jacksonville, Florida); Patrick F. Flowers (Jacksonville, Florida) |
| ABSTRACT | A system is disclosed including a robotic arm movable about a rotational axis to at least one of move and reposition a part at least one of during part creation and after part creation in a micro-gravity environment, wherein creation is performed by at least one of a polymer-based additive manufacturing subsystem and a metallic-based additive manufacturing subsystem and a gripping device attached to the robotic arm which holds the part during at least one of part creation and after part creation. Another system and method are also disclosed. |
| FILED | Wednesday, February 13, 2019 |
| APPL NO | 16/275301 |
| ART UNIT | 1743 — Tires, Adhesive Bonding, Glass/Paper making, Plastics Shaping & Molding |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/003 (20130101) B22F 2202/09 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/25 (20170801) B29C 64/379 (20170801) Original (OR) Class B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 11096382 | Kirkpatrick |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Brian Wayne Kirkpatrick (Fitchburg, Wisconsin) |
| ABSTRACT | Described herein are methods and compositions for modulating bovine birth rate by following a breeding scheme based on the presence of the trio haplotype, which is strongly linked to the propensity to give birth to multiple calves in one event. |
| FILED | Monday, October 15, 2018 |
| APPL NO | 16/160547 |
| ART UNIT | 1632 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/02 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/124 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11098053 | Strong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana); XAVIER UNIVERSITY OF LOUISIANA (New Orleans, Louisiana); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| ASSIGNEE(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana); XAVIER UNIVERSITY OF LOUISIANA (New Orleans, Louisiana); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (Washington, District of Columbia) |
| INVENTOR(S) | Amy Strong (New Orleans, Louisiana); Stephen Boue (Washington, District of Columbia); Matthew Burow (New Orleans, Louisiana); Bruce Bunnell (New Orleans, Louisiana); Quan Jiang (New Orleans, Louisiana); Shilong Zheng (New Orleans, Louisiana); Guangdi Wang (New Orleans, Louisiana) |
| ABSTRACT | Disclosed are daidzein analogs having the formula (I). Also disclosed are compositions, include a disclosed daidzein analogs, methods of preventing or treating bone disease or bone injury and/or stimulating bone growth, in a subject that include administering to the subject an effective amount of disclosed daidzein analog. Disclosed are isolated mesenchymal stem cell that has been altered by treatment a disclosed daidzein analog, daidzein, glycinol, glyceollin I, or glyceollin II, to increase the osteogenic potential of the mesenchymal stem cells. |
| FILED | Friday, April 04, 2014 |
| APPL NO | 14/781494 |
| ART UNIT | 1619 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/352 (20130101) A61K 35/28 (20130101) A61K 35/28 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/54 (20130101) A61L 2300/412 (20130101) A61L 2430/02 (20130101) Heterocyclic Compounds C07D 311/04 (20130101) C07D 311/36 (20130101) C07D 493/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Central Intelligence Agency (CIA)
| US 11101999 | Leavy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wickr Inc. (Pleasanton, California) |
| ASSIGNEE(S) | Amazon Technologies, Inc. (Seattle, Washington) |
| INVENTOR(S) | Thomas Michael Leavy (River Edge, New Jersey); Joël Alwen (Vienna, Austria); Christopher Howell (Freehold, New Jersey) |
| ABSTRACT | The present application describes a method, system, and non-transitory computer-readable medium for end-to-end encryption during a secure communication session. According to the present disclosure, a first device initializes a secure communication session with at least one second device. Initializing the secure communication session includes transmitting an invitation to a secure communication session to the at least one second device. The at least one second device may generate a transmission root key, which may be used to derive a first key for encrypting data transmitted to the first device and a second key for decrypting received data from the first device. The at least one second device may transmit the transmission root key to the first device, which may use the transmission root key to derive a first key to encrypt data transmitted to the at least one second device and a second key to decrypt data received from the at least one second device. |
| FILED | Tuesday, February 25, 2020 |
| APPL NO | 16/800055 |
| ART UNIT | 2437 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/14 (20130101) Original (OR) Class H04L 9/3242 (20130101) H04L 63/061 (20130101) H04L 2209/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 11096854 | Kazerooni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ekso Bionics, Inc. (Richmond, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Ekso Bionics, Inc. (Richmond, California); The Regents of the University of California (Berkeley, California) |
| INVENTOR(S) | Homayoon Kazerooni (Oakland, California); Katherine Strausser (Berkeley, California); Adam Zoss (Berkeley, California); Tim Swift (Albany, California) |
| ABSTRACT | A system and method by which movements desired by a user of a lower extremity orthotic is determined and a control system automatically regulates the sequential operation of powered lower extremity orthotic components to enable the user, having mobility disorders, to walk, as well as perform other common mobility tasks which involve leg movements, perhaps with the use of a gait aid. |
| FILED | Monday, October 30, 2017 |
| APPL NO | 15/797060 |
| ART UNIT | 3785 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/00 (20130101) Original (OR) Class A61H 1/024 (20130101) A61H 1/0244 (20130101) A61H 3/00 (20130101) A61H 3/02 (20130101) A61H 2201/165 (20130101) A61H 2201/1215 (20130101) A61H 2201/1616 (20130101) A61H 2201/1642 (20130101) A61H 2201/5007 (20130101) A61H 2201/5028 (20130101) A61H 2201/5069 (20130101) A61H 2201/5079 (20130101) A61H 2201/5084 (20130101) A61H 2201/5092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 11099148 | Sagüés et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTH FLORIDA (Tampa, Florida) |
| INVENTOR(S) | Alberto Antonio Sagüés (Lutz, Florida); William Clarence Ruth (St. Petersburg, Florida); Leonidas Philip Emmenegger (Tarpon Springs, Florida); Enrique Alberto Paz Velasquez (Tampa, Florida) |
| ABSTRACT | In one embodiment, reinforced soil is assessed using a non-contact method including positioning a reference electrode in close proximity to a surface of the soil without contacting the electrode to the soil surface, vibrating the electrode with a vibration generator, and measuring an electrical potential difference between the electrode and the soil surface, the potential difference being indicative of the condition of a portion of a reinforcement member positioned below the soil surface at the location of the electrode. |
| FILED | Wednesday, April 24, 2019 |
| APPL NO | 16/392991 |
| ART UNIT | 2883 — Optics |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 17/04 (20130101) G01N 17/006 (20130101) G01N 27/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 11098302 | Robinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William H. Robinson (Palo Alto, California); Yann Chong Tan (Palo Alto, California); Jeremy Sokolove (Mountain View, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States Government as Represented by the Department of Veterans Affair (Washington, District of Columbia) |
| INVENTOR(S) | William H. Robinson (Palo Alto, California); Yann Chong Tan (Palo Alto, California); Jeremy Sokolove (Mountain View, California) |
| ABSTRACT | Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest. |
| FILED | Friday, April 27, 2012 |
| APPL NO | 13/261763 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Peptides C07K 16/00 (20130101) C07K 16/1242 (20130101) C07K 16/1271 (20130101) C07K 2317/21 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 2458/10 (20130101) G01N 2500/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
General Services Administration (GSA)
| US 11100290 | Boada et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Jason Boada (Danbury, Connecticut); Qin Shirley Held (Midland Park, New Jersey); Rachel Cohen (Brooklyn, New York); Munish Goyal (Yorktown Heights, New York); Dangaia Sims (Yonkers, New York) |
| ABSTRACT | A method and system for improving linguistic data and storage technology is provided. The method includes receiving data input text from a user and identifying text within the data input text. The data input text is edited and improvements in the data input text are detected via a machine learning process. In response, a modified version of the user interface is generated for allowing additional users to view and modify additional data input text. Change attributes associated with the data input text with respect to the modified version of the user interface are determined and alternative input suggestions are ranked. Editing data and code are generated in response to an editor engine interacting with a hardware controller. The editing data and code is executed thereby updating and modifying functions associated with software engines to increase an efficiency of future recommendations associated with future data input text analysis. |
| FILED | Thursday, May 30, 2019 |
| APPL NO | 16/426113 |
| ART UNIT | 2658 — Linguistics, Speech Processing and Audio Compression |
| CURRENT CPC | Electric Digital Data Processing G06F 40/30 (20200101) Original (OR) Class G06F 40/253 (20200101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6215 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
MITRE Corporation (MITRE)
| US 11099265 | Hamlyn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The MITRE Corporation (McLean, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | Perry F. Hamlyn (Tewksbury, Massachusetts); William A. Dowling (Chelmsford, Massachusetts); Charles Mazzola (Attleboro, Massachusetts) |
| ABSTRACT | A system and method for generating communications waveforms that can operate in congested frequency spaces and in applications in which the receiver is moving with respect to the transmitter is provided. In one or more examples, each symbol to be encoded and transmitted is converted into a sequence of frequency chirps. The sequence of frequencies used by the sequence of chirps is based on the symbol that is to be encoded. Each chirp can have a center frequency, and the frequency can be swept over the duration of the chirp. In this way each chirp can have a varying frequency over the duration of the chirp, but the phase of the chirp can be continuous throughout the duration of the chirp. The bandwidth and sweep rate of the chirp can be based on the expected maximum velocity of the receiver and the transmitter relative to one another. |
| FILED | Tuesday, May 21, 2019 |
| APPL NO | 16/418424 |
| ART UNIT | 2632 — Digital Communications |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 13/282 (20130101) Original (OR) Class G01S 13/584 (20130101) Electric Digital Data Processing G06F 12/0207 (20130101) Transmission H04B 1/69 (20130101) H04B 2001/6912 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 11101120 | Chaudhary et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | SRI International (Menlo Park, California) |
| INVENTOR(S) | Ashish Chaudhary (Safety Harbor, Florida); Robert Timothy Short (St. Petersburg, Florida) |
| ABSTRACT | The disclosure includes an ionization chamber, a first electron multiplier, and a second electron multiplier. The ionization chamber is configured to receive gas molecules from an environment at a pressure. The first electron multiplier is configured to receive a plurality of photons from a photon source, generate a first plurality of electrons from the plurality of photons, and discharge the first plurality of electrons into the ionization chamber to generate a plurality of gas ions from at least a portion of the gas molecules. The second electron multiplier is configured to receive the plurality of gas ions from the ionization chamber and generate a second plurality of electrons from the plurality of gas ions that is proportional to a quantity of the plurality of gas ions. A quantity of electrons of the second plurality of electrons is indicative of the pressure. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 16/664389 |
| ART UNIT | 2867 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 9/0072 (20130101) G01L 19/0007 (20130101) G01L 21/12 (20130101) G01L 21/30 (20130101) G01L 21/32 (20130101) G01L 21/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/64 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 41/02 (20130101) Original (OR) Class H01J 41/04 (20130101) H01J 41/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 11098257 | Hafenstine et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | Glenn Richard Hafenstine (Wheat Ridge, Colorado); Derek Richard Vardon (Lakewood, Colorado); Xiangchen Huo (Golden, Colorado); Nabila Asem Huq (Boulder, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes a first oxide having a phosphate, a ratio of Brønsted acid sites to Lewis acid sites between 0.05 and 1.00, and a total acidity between 50 μmol/g and 300 μmol/g, where the phosphate is at least one of a functional group covalently bonded to the first oxide and/or an anion ionically bonded to the first oxide. |
| FILED | Tuesday, May 12, 2020 |
| APPL NO | 15/930205 |
| ART UNIT | 1622 — Organic Chemistry |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/44 (20130101) B01J 27/195 (20130101) B01J 27/1802 (20130101) B01J 35/023 (20130101) B01J 35/026 (20130101) B01J 35/1014 (20130101) B01J 35/1019 (20130101) B01J 35/1038 (20130101) B01J 35/1042 (20130101) Acyclic or Carbocyclic Compounds C07C 41/09 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/02 (20130101) C10L 1/023 (20130101) C10L 1/026 (20130101) Original (OR) Class C10L 2200/0423 (20130101) C10L 2200/0446 (20130101) C10L 2270/023 (20130101) C10L 2270/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 11098652 | Slaney |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Brandon T. Slaney (Wethersfield, Connecticut) |
| ABSTRACT | Isolation seals for gas turbine engines are described. The isolation seals include a first interface member configured to be fixedly attached to a first case structure, the first interface member being a full-hoop structure, a housing configured to be mounted to a second case structure, a connector pin arranged within the housing and moveable relative to the housing, and a second interface member located on an end of the connector pin, the second interface member being a full-hoop structure. The first interface member and the second interface member are engageable to form a seal therebetween. |
| FILED | Wednesday, May 29, 2019 |
| APPL NO | 16/424562 |
| ART UNIT | 3675 — Wells, Earth Boring/Moving/Working, Excavating, Mining, Harvesters, Bridges, Roads, Petroleum, Closures, Connections, and Hardware |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/005 (20130101) F01D 25/26 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/28 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2240/11 (20130101) F05D 2240/55 (20130101) F05D 2300/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101786 | Kubena et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Randall L. Kubena (Oak Park, California); Deborah J. Kirby (Calabasas, California); Hung Nguyen (Los Angeles, California); David T. Chang (Calabasas, California) |
| ABSTRACT | A MEMS resonator comprising a baseplate wafer; a piezoelectric HF-VHF resonator that comprises a monolithic piezoelectric member having at least two separate spring piezoelectric support members integrally extending therefrom, each spring piezoelectric support member having at least a rounded corner; said piezoelectric resonator being attached to the baseplate wafer by said support members; wherein said monolithic piezoelectric member comprises first and second main surfaces joined by side edges; at least one of said side edges forming an angle of between 90 and 105 degrees with one of the first and second main surfaces. |
| FILED | Monday, February 19, 2018 |
| APPL NO | 15/899122 |
| ART UNIT | 2837 — Electrical Circuits and Systems |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 2201/0271 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00238 (20130101) B81C 2203/036 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/31111 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 3/0072 (20130101) H03H 9/19 (20130101) Original (OR) Class H03H 9/02102 (20130101) H03H 9/02377 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11101991 | Cho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Chongwon Cho (Los Angeles, California); Karim El Defrawy (Santa Monica, California); Daniel C. Apon (College Park, Maryland); Jonathan Katz (Silver Spring, Maryland) |
| ABSTRACT | Described is a system for biometric authentication. The system converts biometric data into a cryptographic key r′ using a reusable fuzzy extractor process having an underlying hash function modeling a random oracle model. The system allows access to secured services when a comparison of r′ to a previously computed cryptographic key r shows a match. |
| FILED | Thursday, May 10, 2018 |
| APPL NO | 15/976583 |
| ART UNIT | 2491 — Cryptography and Security |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/002 (20130101) H04L 9/0618 (20130101) H04L 9/0866 (20130101) Original (OR) Class H04L 9/3231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, August 24, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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