FedInvent™ Patents
Patent Details for Tuesday, October 05, 2021
This page was updated on Wednesday, October 06, 2021 at 05:06 PM GMT
Department of Health and Human Services (HHS)
| US 11134871 | Kintz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Profusa, Inc. (South San Francisco, California) |
| ASSIGNEE(S) | Profusa, Inc. (Emeryville, California) |
| INVENTOR(S) | Gregory J. Kintz (Santa Cruz, California); William A. McMillan (La Honda, California); Natalie Wisniewski (San Francisco, California) |
| ABSTRACT | An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background. |
| FILED | Monday, August 13, 2018 |
| APPL NO | 16/102070 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1459 (20130101) Original (OR) Class A61B 5/7203 (20130101) A61B 5/14532 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
11134907 — Signal processing method and imaging system for scatter correction in computed tomography
| US 11134907 | Rui et al. |
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| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| INVENTOR(S) | Xue Rui (Niskayuna, New York); Mingye Wu (ShangHai, China PRC); Yannan Jin (Niskayuna, New York); Peter Michael Edic (Niskayuna, New York); Bruno Kristiaan Bernard De Man (Niskayuna, New York) |
| ABSTRACT | A signal processing method is disclosed, which includes detecting a total intensity of X-rays passing through an object comprising multiple materials; obtaining at least one set of basis information of basis material information of the multiple materials and basis component information of photon-electric absorption basis component and Compton scattering basis component of the object; estimating a scatter intensity component of the detected X-rays based on the at least one set of basis information and the detected total intensity; and obtaining an intensity estimate of primary X-rays incident on a detector based on the detected total intensity and the estimated scatter intensity component. An imaging system adopting the above signal processing method is also disclosed. |
| FILED | Wednesday, February 05, 2020 |
| APPL NO | 16/782584 |
| ART UNIT | 2662 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/50 (20130101) A61B 6/482 (20130101) Original (OR) Class A61B 6/4241 (20130101) A61B 6/5205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11134918 | Wodnicki et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | University of Southern California (Los Angeles, California); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Robert G. Wodnicki (Los Angeles, California); Qifa Zhou (Arcadia, California); Thomas Matthew Cummins (Venice, California); Douglas N. Stephens (Davis, California); Katherine W. Ferrara (Davis, California) |
| ABSTRACT | A modular array includes modular array includes one or more array modules. Each array module includes one or more transducer arrays, where each of the one or more transducer arrays includes a plurality of piezoelectric elements; a conducting interposer arranged and configured to provide acoustic absorbing backing for the one or more transducer arrays; and one or more Application Specific Integrated Circuits (ASICs). The conducting interposer and the one or more ASICs are in electrical contact with each other at a first direct electrical interface. Additionally, the conducting interposer and the one or more transducer arrays are in electrical contact with each other at a second direct electrical interface. |
| FILED | Saturday, February 18, 2017 |
| APPL NO | 15/999109 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/4488 (20130101) Original (OR) Class Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0622 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/04 (20130101) H01L 41/1132 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11134950 | Blatter et al. |
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| FUNDED BY |
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| APPLICANT(S) | Advent Access Pte. Ltd. (Singapore, Singapore) |
| ASSIGNEE(S) | Advent Access Pte. Ltd. (Singapore, Singapore) |
| INVENTOR(S) | Duane D. Blatter (Salt Lake, Utah); Trent J. Perry (Kaysville, Utah); Nathaniel P. Young (Salt Lake City, Utah); Jeffrey E. Ransden (Fairfield, Connecticut) |
| ABSTRACT | A method of attaching an implant to a vessel can include clamping a portion of a wall of a vessel within a patient. The method can also include positioning an implant adjacent to an outer surface of the wall of the vessel, and the implant can include an access port. The method can also include cutting the wall of the vessel about the portion of the wall that has been clamped, passing the portion of the wall that has been clamped and that has been cut about through the implant to remove the portion of the wall from the patient and to provide an opening in the vessel, and securing the implant to the vessel such that the access port is in direct fluid communication with an interior of the vessel via the opening in the vessel. |
| FILED | Wednesday, March 13, 2019 |
| APPL NO | 16/352693 |
| ART UNIT | 3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/11 (20130101) Original (OR) Class A61B 17/115 (20130101) A61B 17/0218 (20130101) A61B 2017/1107 (20130101) A61B 2017/1135 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 39/02 (20130101) A61M 39/0247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135000 | Curley |
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| FUNDED BY |
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| APPLICANT(S) | Thermedical, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | Thermedical, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Michael G. Curley (Weston, Massachusetts) |
| ABSTRACT | Devices, systems, and methods for degassing fluid prior to applying fluid to a treatment site during ablation therapy are provided. In one embodiment, an ablation system can include an elongate body, an ablation element, a heating assembly, and a fluid source. Fluid in the fluid source can be at least partially degassed prior to being provided as part of the system, or, in some embodiments, a degassing apparatus can be provided that can be configured to degas fluid within the system prior to applying the fluid to the treatment site. The degassing apparatus can include one or more gas-permeable and fluid-impermeable tubes disposed therein, which can allow gas to be removed from fluid passing through the apparatus. Other exemplary devices, systems, and methods are also provided. |
| FILED | Tuesday, April 02, 2019 |
| APPL NO | 16/373104 |
| ART UNIT | 3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/04 (20130101) A61B 18/16 (20130101) A61B 18/082 (20130101) Original (OR) Class A61B 18/1477 (20130101) A61B 2017/00526 (20130101) A61B 2018/00029 (20130101) A61B 2018/00041 (20130101) A61B 2018/046 (20130101) A61B 2018/162 (20130101) A61B 2018/00577 (20130101) A61B 2018/00642 (20130101) A61B 2018/00773 (20130101) A61B 2018/00791 (20130101) A61B 2018/00797 (20130101) A61B 2018/00809 (20130101) A61B 2018/00821 (20130101) A61B 2018/1425 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 17/03 (20130101) F04B 19/22 (20130101) F04B 41/02 (20130101) F04B 43/04 (20130101) F04B 49/06 (20130101) Rotary-piston, or Oscillating-piston, Positive-displacement Machines for Liquids; Rotary-piston, or Oscillating-piston, Positive-displacement Pumps F04C 2270/041 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49016 (20150115) Y10T 29/49085 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135186 | Cooley et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Christina Cooley (San Antonio, Texas); Jeffery W. Kelly (Solana Beach, California); Ryan Paxman (San Diego, California); Lars Plate (San Diego, California); R. Luke Wiseman (Chula Vista, California) |
| ABSTRACT | The invention provides compounds for activating the activating transcription factor 6 (ATF6) arm of the unfolded protein response (UPR), or activating the transcriptional targets of ATF6, in the endoplasmic reticulum of a cell, the compounds being of any of formulas (I) through (IX) as described herein. The compounds can be used for treatment of conditions involving gain-of-toxic-function and loss-of-function folding disorders including lysosomal storage diseases, antitrypsin-associated emphysema and similar diseases. These molecules are also expected to have disease-ameliorating effects in Alzheimer's disease and diabetes. |
| FILED | Thursday, December 29, 2016 |
| APPL NO | 16/066555 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/47 (20130101) A61K 31/50 (20130101) A61K 31/53 (20130101) A61K 31/136 (20130101) A61K 31/137 (20130101) A61K 31/167 (20130101) Original (OR) Class A61K 31/381 (20130101) A61K 31/415 (20130101) A61K 31/422 (20130101) A61K 31/428 (20130101) A61K 31/429 (20130101) A61K 31/437 (20130101) A61K 31/454 (20130101) A61K 31/497 (20130101) A61K 31/506 (20130101) A61K 31/4174 (20130101) A61K 31/4178 (20130101) A61K 31/4184 (20130101) A61K 31/4196 (20130101) A61K 31/4245 (20130101) A61K 31/4439 (20130101) A61K 31/5377 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135187 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
| ASSIGNEE(S) | National Institutes of Health (NIH) (Bethesda, Maryland); U.S. Dept. of Health Human Services, (DHHS) (Bethesda, Maryland); U.S. Government NIH Division of Extramural Inventions and Technology Resources (DEITR) (Bethesda, Maryland) |
| INVENTOR(S) | Mong Heng Wang (Martinez, Georgia); Mohamed Al-Shabrawey (Evans, Georgia) |
| ABSTRACT | Compositions and methods for treating diabetic retinopathy or symptoms thereof are provided. The disclosed compositions and methods for treating diabetic retinopathy contravene the existing paradigm that Renin-Angiotensin System (RAS) blockade alone can treat, prevent, or reduce diabetic retinopathy. The disclosed compositions and methods include a combination or alternation of EET antagonists and ATI antagonists. |
| FILED | Tuesday, August 21, 2018 |
| APPL NO | 16/106421 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 9/0053 (20130101) A61K 31/18 (20130101) Original (OR) Class A61K 31/336 (20130101) A61K 31/4178 (20130101) A61K 31/4184 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135203 | Bugni et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Timothy Bugni (Madison, Wisconsin); Thomas Wyche (Chelsea, Massachusetts); David Andes (Madison, Wisconsin); Douglas Braun (Mount Horeb, Wisconsin) |
| ABSTRACT | An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed. |
| FILED | Tuesday, May 01, 2018 |
| APPL NO | 15/968456 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/429 (20130101) Original (OR) Class A61K 31/7048 (20130101) A61K 31/7048 (20130101) A61K 31/7052 (20130101) A61K 31/7052 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 513/18 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 17/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135207 | Romero et al. |
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| FUNDED BY |
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| APPLICANT(S) | Centaurus Therapeutics (Half Moon Bay, California) |
| ASSIGNEE(S) | Centaurus Therapeutics (Half Moon Bay, California) |
| INVENTOR(S) | Donna L. Romero (Chesterfield, Missouri); John M. McCall (Boca Grande, Florida); Jeremy Blitzer (San Francisco, California) |
| ABSTRACT | Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic, cardiovascular, fibrotic, autoimmune/chronic inflammatory diseases, cystic fibrosis, various cancers, neurodegenerative diseases, lipid storage disorders, and ischemia/reperfusion injury, where inhibition of Des1 is expected to be therapeutic to a patient. Methods of inhibition of Des1 activity in a human or animal subject are also provided. |
| FILED | Wednesday, December 13, 2017 |
| APPL NO | 16/468637 |
| ART UNIT | 1624 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 31/44 (20130101) Original (OR) Class A61K 31/167 (20130101) A61K 31/416 (20130101) A61K 31/444 (20130101) A61K 31/496 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/06 (20180101) A61P 3/10 (20180101) A61P 9/10 (20180101) A61P 11/00 (20180101) A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 233/65 (20130101) Heterocyclic Compounds C07D 213/73 (20130101) C07D 231/56 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135209 | Cuny et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF HOUSTON SYSTEM (Houston, Texas); TRUSTEES OF TUFTS COLLEGE (Medford, Massachusetts) |
| ASSIGNEE(S) | University of Houston System (Houston, Texas); Trustees of Tufts College (Medford, Massachusetts) |
| INVENTOR(S) | Gregory Cuny (Houston, Texas); Chalada Suebsuwong (Houston, Texas); Alexei Degterev (Brookline, Massachusetts) |
| ABSTRACT | Identified compounds demonstrate protein kinase inhibitory activity and inhibition of dependent cell signaling pathways, such as NOD2 cell signaling. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit. |
| FILED | Thursday, March 29, 2018 |
| APPL NO | 16/496503 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/444 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135213 | Miranker et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Andrew Miranker (Guilford, Connecticut); Sunil Kumar (New York, New York) |
| ABSTRACT | The present invention provides novel compounds that are quinoline foldamers. Such foldamers stabilize and bind to islet amyloid polypeptide (IAPP). In certain embodiments, the quinoline foldamers of the invention are soluble and cross biological membranes without cellular assistance. The present invention further provides novel method of preventing or treating diabetes in a subject in need thereof by administering to the subject an effective amount of at least one quinoline foldamer of the invention. The present invention further provides novel method of preventing or treating a neurodegenerative disease caused by a misfolded and/or unstructured protein in a subject in need thereof by administering to the subject an effective amount of at least one quinoline foldamer of the invention. |
| FILED | Thursday, October 27, 2016 |
| APPL NO | 15/769914 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) Original (OR) Class A61K 45/06 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135222 | Meyerowitz et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSIITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Justin Gabriel Meyerowitz (San Francisco, California); William Clay Gustafson (San Francisco, California); William A. Weiss (San Francisco, California); Nicholas T. Hertz (San Francisco, California); Kevan M. Shokat (San Francisco, California) |
| ABSTRACT | Disclosed herein inter alia are compositions and methods useful in the treatment of cancer and for modulating the activity of Aurora A kinase and/or a Myc family protein. |
| FILED | Friday, November 20, 2015 |
| APPL NO | 14/948078 |
| ART UNIT | 1628 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class Heterocyclic Compounds C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135223 | Chae et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Wook-Jin Chae (New Haven, Connecticut); Alfred Bothwell (Guilford, Connecticut) |
| ABSTRACT | The present invention provides compositions and methods for inhibiting Dkk-1 for treating or preventing an inflammatory or inflammatory-related disease or disorder. |
| FILED | Friday, January 20, 2017 |
| APPL NO | 16/071546 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class A61K 31/538 (20130101) A61K 31/573 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) A61P 33/02 (20180101) Peptides C07K 16/18 (20130101) C07K 16/2896 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/24 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135224 | Schneider et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | NEW YORK UNIVERSITY (New York, New York) |
| INVENTOR(S) | Robert J. Schneider (New York, New York); Phillip A. Geter (Belmont, California); Sofia Bakogianni (New York, New York) |
| ABSTRACT | Aspects of the technology are directed to a method of increasing sensitivity of estrogen receptor positive (ER+) breast cancer cells to treatment with an endocrine therapy. The method involves selecting ER+ breast cancer cells, and administering to the selected cells (i) one or more mammalian target of rapamycin (mTOR) inhibitors and (ii) one or more MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1) inhibitors in an effective amount to increase the sensitivity of the ER+ breast cancer cells to treatment with the endocrine therapy. Methods of treating a subject having ER+ breast cancer are also disclosed. |
| FILED | Friday, December 20, 2019 |
| APPL NO | 16/723573 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 2501/999 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135228 | Serhan et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BRIGHAM AND WOMEN'S HOSPITAL (Boston, Massachusetts) |
| ASSIGNEE(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Charles N. Serhan (Needham, Massachusetts); Jesmond P. Dalli (Brookline, Massachusetts); Nan Chiang (Somerville, Massachusetts) |
| ABSTRACT | A family of bioactive compounds identified in self-resolving inflammatory exudates is disclosed. The compounds give UV chromophores characteristics of a conjugated triene double bond system coupled to an auxochrome allylic to the triene. Further elucidation of the compounds reveals that they have an oxylipin backbone conjugated to a peptide or amino acid moiety via an auxochrome. In some embodiments the auxochrome is sulfur. However, the auxochrome may be NH, CH2 or O. The compounds have potent bioactivity, in vitro, and, in vivo, including promoting resolution of infection, stimulating macrophage phagocytosis of bacteria; protecting tissues from neutrophil mediated damage, promoting tissue repair and regeneration and preventing or limiting second organ reflow/reperfusion damage. |
| FILED | Wednesday, October 07, 2015 |
| APPL NO | 15/517016 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/557 (20130101) Original (OR) Class A61K 47/64 (20170801) A61K 47/542 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135231 | O'Connor et al. |
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| FUNDED BY |
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| APPLICANT(S) | Tufts Medical Center, Inc. (Boston, Massachusetts); Washington State University (Pullman, Washington); University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | Washington State University (Pullman, Washington); Tufts Medical Center, Inc. (Boston, Massachusetts); University of Utah (Salt Lake City, Utah) |
| INVENTOR(S) | Roberta O'Connor (Pullman, Washington); Eric W. Schmidt (Salt Lake City, Utah) |
| ABSTRACT | Methods and compositions for preventing and/or treating diseases and conditions caused by certain apicomplexan infections are provided. The methods involve administering/providing to a subject one or more of tartrolon D and E, including isomers thereof. Exemplary apicomplexan infections that are prevented/treated by the compounds of the invention include those caused by Cryptosporidium, Babesia, Cyclospora, Isospora, Plasmodium, Sarcocystis, Besnoitia, Hammondia, Neospora, Theileria and Toxoplasma. |
| FILED | Thursday, December 07, 2017 |
| APPL NO | 16/467320 |
| ART UNIT | 1625 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135236 | Burridge |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Paul W. Burridge (Chicago, Illinois) |
| ABSTRACT | Disclosed are methods, pharmaceutical compositions, kits, and systems for treating or preventing cardiotoxicity in a subject undergoing treatment with an anthracycline chemotherapeutic agent. The methods, pharmaceutical compositions, kits, and systems typically include or utilize an agonist of the retinoic acid receptor gamma (RARG). |
| FILED | Friday, April 05, 2019 |
| APPL NO | 16/376392 |
| ART UNIT | 1623 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 31/196 (20130101) A61K 31/381 (20130101) A61K 31/415 (20130101) A61K 31/704 (20130101) Original (OR) Class A61K 31/4436 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135240 | Singh et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Anirudha Singh (Baltimore, Maryland); Shimon Unterman (Brookline, Massachusetts); Michael Corvelli (Baltimore, Maryland); Jennifer Elisseeff (Baltimore, Maryland) |
| ABSTRACT | The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (HA). The biomaterial compositions utilize small HA binding peptides and extracellular matrix binding (ECM) peptides that are tethered to synthetic biocompatible polymers. When tethered to the polymers, the peptide region allows the polymers to bind to HA and to tissues such as cartilage. The novel biomaterial compositions can be used to coat or chemically modify cartilage or tissues with a biologically compatible polymer having HA binding peptides, which allow HA to bind to the surface of the cartilage or tissues. Methods of using same are also provided. |
| FILED | Tuesday, January 29, 2019 |
| APPL NO | 16/260191 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 31/728 (20130101) Original (OR) Class A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 47/60 (20170801) A61K 47/6957 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/20 (20130101) A61L 27/227 (20130101) A61L 2400/10 (20130101) A61L 2400/18 (20130101) A61L 2430/06 (20130101) A61L 2430/16 (20130101) Compositions of Macromolecular Compounds C08L 5/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135252 | Costa-Mattioli et al. |
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| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas) |
| INVENTOR(S) | Mauro Costa-Mattioli (Houston, Texas); Shelly Alexandra Buffington (Houston, Texas) |
| ABSTRACT | Embodiments of the disclosure concern methods and compositions related to manipulation of the microbiome in an individual having at least one social behavior deficit. In particular embodiments, an individual has at least one social behavior deficit and was born from a mother who during pregnancy was obese, overweight, or on a high-fat diet during pregnancy or carries mutations associated with neurodevelopmental disorders. In specific embodiments, the individual having at least one social behavior deficit is provided an effective amount of Lactobacillus reuteri for the improvement of at least one symptom of a social behavior deficit. |
| FILED | Saturday, April 15, 2017 |
| APPL NO | 16/093593 |
| ART UNIT | 1699 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 9/1234 (20130101) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2002/00 (20130101) A23V 2200/322 (20130101) A23V 2200/3204 (20130101) Indexing Scheme Relating to Lactic or Propionic Acid Bacteria Used in Foodstuffs or Food Preparation A23Y 2220/71 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/02 (20130101) A61K 9/20 (20130101) A61K 9/0053 (20130101) A61K 35/742 (20130101) Original (OR) Class A61K 35/747 (20130101) A61K 2035/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135268 | Corey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); University of Washington (Seattle, Washington) |
| INVENTOR(S) | Lawrence Corey (Mercer Island, Washington); Jia Zhu (Kenmore, Washington); Tao Peng (Kenmore, Washington) |
| ABSTRACT | The present disclosure provides compositions, kits, and methods of promoting neural growth and/or neural survival using IL-17c. The compositions, kits, and methods can be used to promote neural growth and/or neural survival in a variety of conditions where such growth and survival is beneficial. |
| FILED | Thursday, July 07, 2016 |
| APPL NO | 15/742415 |
| ART UNIT | 1649 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/20 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) A61P 31/00 (20180101) Peptides C07K 14/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135280 | Aman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTEGRATED BIOTHERAPEUTICS, INC. (Rockville, Maryland); INTEGRAL MOLECULAR, INC. (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | INTEGRATED BIOTHERAPEUTICS, INC. (Rockville, Maryland); INTEGRAL MOLECULAR, INC. (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Mohammad Javad Aman (Rockville, Maryland); Katie A. Howell (North Bethesda, Maryland); Edgar Davidson (Philadelphia, Pennsylvania); Benjamin J. Doranz (Drexel Hill, Pennsylvania) |
| ABSTRACT | Provided herein are methods of incorporating substitutions of specified residues into a filovirus GP in order to increase immunogenicity and/or broaden the cross-reactivity of the protective immune response against other filovirus members. Also provided herein are mutant filovirus GPs comprising such substitutions. |
| FILED | Monday, March 27, 2017 |
| APPL NO | 16/084151 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2760/14122 (20130101) C12N 2760/14134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135292 | Lai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | Albert Einstein College of Medicine (Bronx, New York) |
| INVENTOR(S) | Jonathan R. Lai (Dobbs Ferry, New York); Julia Frei (Bronx, New York); Elisabeth Nyakatura (New York, New York) |
| ABSTRACT | Methods for treating and for preventing filovirus infections are disclosed, as well as compositions therefor. |
| FILED | Thursday, August 22, 2019 |
| APPL NO | 16/548309 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/42 (20130101) Original (OR) Class Peptides C07K 16/10 (20130101) C07K 2317/24 (20130101) C07K 2317/31 (20130101) C07K 2317/64 (20130101) C07K 2317/76 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135299 | Robinson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | the regents of the university of california (Oakland, California) |
| INVENTOR(S) | Peter V. Robinson (Berkeley, California); Cheng-Ting Tsai (Berkeley, California); Carolyn R. Bertozzi (Berkeley, California) |
| ABSTRACT | Pharmaceutical compositions are provided for extending the serum half-life of a therapeutic agent. The composition may include a strained alkyne-labeled therapeutic agent. Also provided is a strained alkyne-carrier protein adduct including a vinyl thioether-linkage to a cysteine residue of the carrier protein. Methods of chemoselectively modifying a carrier protein are provided, that include conjugating a cysteine residue of a carrier protein with a cyclooctyne-labeled cargo agent to produce a vinyl thioether-linked conjugate. Also provided is a method of increasing the in vivo half-life of a bioactive agent including administering a strained alkyne-labeled bioactive agent to a subject. |
| FILED | Thursday, June 16, 2016 |
| APPL NO | 15/576226 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/545 (20170801) Original (OR) Class A61K 47/555 (20170801) A61K 47/643 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) A61P 31/00 (20180101) A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135309 | Lam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Kit S. Lam (Oakland, California); Yuanpei Li (Oakland, California); Kai Xiao (Oakland, California); Caihong Feng (Oakland, California) |
| ABSTRACT | The present invention provides a nanoparticle including at least one poly(vinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa, substituted with one or more moieties selected from: a therapeutic agent having a boronic acid moiety, wherein the therapeutic agent is covalently linked to the PVA via a boronate ester bond; a crosslinking group having a disulfide moiety, wherein the crosslinking group is covalently linked to the PVA, and a porphyrin, wherein the porphyrin is covalently linked to the PVA. Use of the nanoparticles for tumor detection and the treatment of diseases, including methods for photodynamic therapy and photothermal therapy, are also described. |
| FILED | Monday, August 15, 2016 |
| APPL NO | 15/752326 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/5138 (20130101) A61K 31/69 (20130101) A61K 47/32 (20130101) A61K 47/58 (20170801) A61K 47/546 (20170801) A61K 47/547 (20170801) A61K 47/6847 (20170801) A61K 47/6869 (20170801) A61K 47/6933 (20170801) Original (OR) Class A61K 49/1854 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 230/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135316 | Achilefu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Samuel Achilefu (St. Louis, Missouri); Nalinikanth Kotagiri (St. Louis, Missouri) |
| ABSTRACT | The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT). In an aspect, the invention encompasses a composition comprising at least two radiation-sensitive molecules. In another aspect, the invention encompasses a composition comprising a radiation-sensitive molecule and a targeting agent. In still another aspect, the invention encompasses a method for administering Cerenkov radiation-induced therapy (CRIT) to a target tissue in a subject. The method comprises administering to the subject an effective amount of a composition B comprising at least one radiation-sensitive molecule and administering to the subject an amount of a Cerenkov radiation (CR)-emitting radionuclide effective to activate the radiation-sensitive molecule, thereby administering CRIT to the target tissue in the subject. |
| FILED | Monday, February 02, 2015 |
| APPL NO | 15/115457 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) A61K 41/0057 (20130101) A61K 49/0013 (20130101) A61K 49/0021 (20130101) A61K 49/0056 (20130101) Original (OR) Class A61K 51/0474 (20130101) A61K 51/0482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135318 | Ran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Chongzhao Ran (Winchester, Massachusetts); Anna Moore (Stoneham, Massachusetts); Jian Yang (Boston, Massachusetts) |
| ABSTRACT | Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided. |
| FILED | Thursday, June 29, 2017 |
| APPL NO | 16/314153 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/04 (20130101) A61K 51/0453 (20130101) Original (OR) Class A61K 51/0455 (20130101) A61K 2123/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) A61P 25/28 (20180101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/002 (20130101) C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 49/248 (20130101) C07C 49/252 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101) C07F 5/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135320 | Zeglis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Brian Zeglis (New York, New York); Jason Lewis (New York, New York); Thomas Reiner (New York, New York); Jacob Lee Houghton (New York, New York); Jan-Philip Meyer (New York, New York); Christian Brand (New York, New York) |
| ABSTRACT | Described herein are Tz/TCO-based pretargeting strategies using an Al[18F]-NOTA-labeled tetrazine radioligand. This imaging strategy enables delineation of cancer at earlier time points compared to other imaging strategies and further decreases the radiation dose to healthy tissues compared to directly labeled antibodies. Al-based 18F imaging of small molecules, such as tetrazine, has not been previously achieved due to the decomposition of tetrazine during radiofluorination. Radiofluorination is advantageous over other radiolabeling methods because, in addition to having a shorter half-life, 18F is more readily available to produce and therefore integrated into hospital workflows. |
| FILED | Wednesday, November 28, 2018 |
| APPL NO | 16/203513 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6897 (20170801) A61K 51/0453 (20130101) A61K 51/0482 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135325 | Osinski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marek A. Osinski (Albuquerque, New Mexico); Hugh D. C. Smyth (Austin, Texas); Leisha Marie Armijo (Albuquerque, New Mexico); Hennaka Mudiyanselage Herath Nihal Bandara (Herston, Australia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marek A. Osinski (Albuquerque, New Mexico); Hugh D. C. Smyth (Austin, Texas); Leisha Marie Armijo (Albuquerque, New Mexico); Hennaka Mudiyanselage Herath Nihal Bandara (Herston, Australia) |
| ABSTRACT | Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron. |
| FILED | Tuesday, February 09, 2016 |
| APPL NO | 15/549974 |
| ART UNIT | 1617 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/26 (20130101) A01N 25/26 (20130101) A01N 59/16 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 33/26 (20130101) A61K 41/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/02 (20130101) Original (OR) Class A61L 2/238 (20130101) A61L 29/106 (20130101) A61L 31/088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135340 | Miller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Lloyd S. Miller (Ellicott City, Maryland); Hai-Quan Mao (Baltimore, Maryland); Alyssa Ashbaugh (Baltimore, Maryland); Xuesong Jiang (Lutherville-Timonium, Maryland); Jesse Zheng (Johns Creek, Georgia) |
| ABSTRACT | The presently disclosed subject matter provides a coating composition which allows for the co-delivery of two or more bioactive agents with independent control of loading level and release profile for each bioactive agent, an implantable medical device coated with the coating composition, and methods for preparing the coating composition. |
| FILED | Wednesday, February 08, 2017 |
| APPL NO | 16/076606 |
| ART UNIT | 1611 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/04 (20130101) A61L 27/18 (20130101) A61L 27/18 (20130101) A61L 27/32 (20130101) A61L 27/34 (20130101) Original (OR) Class A61L 27/46 (20130101) A61L 27/54 (20130101) A61L 27/58 (20130101) A61L 2400/12 (20130101) A61L 2420/02 (20130101) A61L 2420/08 (20130101) Compositions of Macromolecular Compounds C08L 67/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135363 | Rosinko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beta Bionics, Inc. (Concord, Massachusetts) |
| ASSIGNEE(S) | Beta Bionics, Inc. (Concord, Massachusetts) |
| INVENTOR(S) | Michael J. Rosinko (Anaheim, California); David Chi-Wai Lim (Irvine, California); Edward R. Damiano (Acton, Massachusetts); Firas H. El-Khatib (Allston, Massachusetts); Himanshu Patel (Rancho Santa Margarita, California) |
| ABSTRACT | Systems and methods relate to an ambulatory medicament device that can generate a dose control signal to cause a medicament pump to infuse medicament into a subject. The system can analyze status to determine whether an alarm condition for the ambulatory medicament device or for a subject is already present in a list of pending alarm conditions. If the alarm is not present, the system can determine a severity level of the alarm condition from among a plurality of severity levels and annunciate the alarm condition using one or more annunciation patterns selected based on the severity level of the alarm condition for the medicament device or for the subject. The system may maintain an indication of the alarm condition on the list of pending alarm conditions until the alarm condition is resolved. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/062167 |
| ART UNIT | 3783 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14532 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) A61M 5/172 (20130101) Original (OR) Class A61M 5/1723 (20130101) A61M 5/14244 (20130101) A61M 5/14248 (20130101) A61M 5/16831 (20130101) A61M 2005/1726 (20130101) A61M 2005/14208 (20130101) A61M 2205/18 (20130101) A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/505 (20130101) A61M 2205/581 (20130101) A61M 2205/582 (20130101) A61M 2205/583 (20130101) A61M 2205/609 (20130101) A61M 2205/3327 (20130101) A61M 2205/3546 (20130101) A61M 2205/3553 (20130101) A61M 2205/3584 (20130101) A61M 2205/3592 (20130101) A61M 2230/201 (20130101) Electric Digital Data Processing G06F 3/04847 (20130101) G06F 3/04883 (20130101) G06F 8/61 (20130101) G06F 8/65 (20130101) G06F 8/656 (20180201) G06F 21/31 (20130101) G06F 21/84 (20130101) G06F 21/305 (20130101) G06F 21/6245 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/18 (20130101) G08B 21/0453 (20130101) G08B 25/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/17 (20180101) G16H 40/00 (20180101) G16H 40/40 (20180101) G16H 40/60 (20180101) G16H 40/67 (20180101) G16H 50/30 (20180101) G16H 80/00 (20180101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/30 (20130101) H04L 9/088 (20130101) H04L 63/101 (20130101) H04L 67/34 (20130101) Wireless Communication Networks H04W 76/10 (20180201) H04W 76/14 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135364 | Rosinko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beta Bionics, Inc. (Concord, Massachusetts) |
| ASSIGNEE(S) | Beta Bionics, Inc. (Concord, Massachusetts) |
| INVENTOR(S) | Michael J. Rosinko (Anaheim, California); Edward R. Damiano (Acton, Massachusetts); David Chi-Wai Lim (Irvine, California); Firas H. El-Khatib (Allston, Massachusetts); Justin P. Brown (Tustin, California); Bryan Dale Knodel (Flagstaff, Arizona) |
| ABSTRACT | Systems and methods are disclosed herein for monitoring the status of an ambulatory medical device and the health condition of a subject that receives therapy from the ambulatory medical device. The ambulatory medical device can have a touchscreen display user interface to receive input signals from a user and display alarm conditions associated with the status of an ambulatory medical device or health condition of a subject. The disclosed methods and systems can determine whether status information received from a monitoring system interface satisfies an alarm condition for the ambulatory medicament device or for the subject. If the status information satisfies an alarm condition, the touchscreen user interface can display one or more alarm status indicators corresponding to the alarm condition. The user can activate a therapy change interface on the touchscreen display and modify a control parameter of the ambulatory medical device that controls the therapy delivery to the subject. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/062353 |
| ART UNIT | 3783 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14532 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) A61M 5/172 (20130101) Original (OR) Class A61M 5/1723 (20130101) A61M 5/14244 (20130101) A61M 5/14248 (20130101) A61M 5/16831 (20130101) A61M 2005/1726 (20130101) A61M 2005/14208 (20130101) A61M 2205/18 (20130101) A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/505 (20130101) A61M 2205/581 (20130101) A61M 2205/582 (20130101) A61M 2205/583 (20130101) A61M 2205/609 (20130101) A61M 2205/3327 (20130101) A61M 2205/3546 (20130101) A61M 2205/3553 (20130101) A61M 2205/3584 (20130101) A61M 2205/3592 (20130101) A61M 2230/201 (20130101) Electric Digital Data Processing G06F 3/04847 (20130101) G06F 3/04883 (20130101) G06F 8/61 (20130101) G06F 8/65 (20130101) G06F 8/656 (20180201) G06F 21/31 (20130101) G06F 21/84 (20130101) G06F 21/305 (20130101) G06F 21/6245 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/18 (20130101) G08B 21/0453 (20130101) G08B 25/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/17 (20180101) G16H 40/00 (20180101) G16H 40/40 (20180101) G16H 40/60 (20180101) G16H 40/67 (20180101) G16H 50/30 (20180101) G16H 80/00 (20180101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/30 (20130101) H04L 9/088 (20130101) H04L 63/101 (20130101) H04L 67/34 (20130101) Wireless Communication Networks H04W 76/10 (20180201) H04W 76/14 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135365 | Rosinko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beta Bionics, Inc. (Concord, Massachusetts) |
| ASSIGNEE(S) | Beta Bionics, Inc. (Concord, Massachusetts) |
| INVENTOR(S) | Michael J. Rosinko (Las Vegas, Nevada); Himanshu Patel (Rancho Santa Margarita, California); Edward R. Damiano (Acton, Massachusetts); Firas H. El-Khatib (Allston, Massachusetts) |
| ABSTRACT | An ambulatory medicament device can generate a dose control signal for delivery of medicament to a subject and secure at least some functionality of a user interface of the ambulatory medicament device. The ambulatory medicament device can have a locked state that restricts modification of at least one control parameter. The ambulatory medicament device can have an unlocked state that allows modification of at least one control parameter. The ambulatory medicament device can accept a user input of a security code that is validated against a passcode to enter from the locked state to the unlocked state. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/062399 |
| ART UNIT | 3783 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14532 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) A61M 5/172 (20130101) Original (OR) Class A61M 5/1723 (20130101) A61M 5/14244 (20130101) A61M 5/14248 (20130101) A61M 5/16831 (20130101) A61M 2005/1726 (20130101) A61M 2005/14208 (20130101) A61M 2205/18 (20130101) A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/505 (20130101) A61M 2205/581 (20130101) A61M 2205/582 (20130101) A61M 2205/583 (20130101) A61M 2205/609 (20130101) A61M 2205/3327 (20130101) A61M 2205/3546 (20130101) A61M 2205/3553 (20130101) A61M 2205/3584 (20130101) A61M 2205/3592 (20130101) A61M 2230/201 (20130101) Electric Digital Data Processing G06F 3/04847 (20130101) G06F 3/04883 (20130101) G06F 8/61 (20130101) G06F 8/65 (20130101) G06F 8/656 (20180201) G06F 21/31 (20130101) G06F 21/84 (20130101) G06F 21/305 (20130101) G06F 21/6245 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/18 (20130101) G08B 21/0453 (20130101) G08B 25/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/17 (20180101) G16H 40/00 (20180101) G16H 40/40 (20180101) G16H 40/60 (20180101) G16H 40/67 (20180101) G16H 50/30 (20180101) G16H 80/00 (20180101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/30 (20130101) H04L 9/088 (20130101) H04L 63/101 (20130101) H04L 67/34 (20130101) Wireless Communication Networks H04W 76/10 (20180201) H04W 76/14 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135366 | Rosinko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beta Bionics, Inc. (Concord, Massachusetts) |
| ASSIGNEE(S) | Beta Bionics, Inc. (Concord, Massachusetts) |
| INVENTOR(S) | Michael J. Rosinko (Anaheim, California); Himanshu Patel (Rancho Santa Margarita, California); Edward R. Damiano (Acton, Massachusetts); Firas H. El-Khatib (Allston, Massachusetts); David Chi-Wai Lim (Irvine, California) |
| ABSTRACT | An ambulatory medical device can detect a device condition and determine if the device condition satisfies a set of normal operating parameters. If the normal operating parameters are not satisfied, the ambulatory medical device can determine if the device condition stratifies a set of minimum operating parameters. If the minimum operating parameters are satisfied, the ambulatory medical device can maintain a delivery of therapy to a subject and generate an alert based on the device condition. |
| FILED | Friday, October 02, 2020 |
| APPL NO | 17/062415 |
| ART UNIT | 3783 — Body Treatment, Kinestherapy, and Exercising |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14532 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) A61M 5/172 (20130101) Original (OR) Class A61M 5/1723 (20130101) A61M 5/14244 (20130101) A61M 5/14248 (20130101) A61M 5/16831 (20130101) A61M 2005/1726 (20130101) A61M 2005/14208 (20130101) A61M 2205/18 (20130101) A61M 2205/50 (20130101) A61M 2205/52 (20130101) A61M 2205/502 (20130101) A61M 2205/505 (20130101) A61M 2205/581 (20130101) A61M 2205/582 (20130101) A61M 2205/583 (20130101) A61M 2205/609 (20130101) A61M 2205/3327 (20130101) A61M 2205/3546 (20130101) A61M 2205/3553 (20130101) A61M 2205/3584 (20130101) A61M 2205/3592 (20130101) A61M 2230/201 (20130101) Electric Digital Data Processing G06F 3/04847 (20130101) G06F 3/04883 (20130101) G06F 8/61 (20130101) G06F 8/65 (20130101) G06F 8/656 (20180201) G06F 21/31 (20130101) G06F 21/84 (20130101) G06F 21/305 (20130101) G06F 21/6245 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/18 (20130101) G08B 21/0453 (20130101) G08B 25/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/17 (20180101) G16H 40/00 (20180101) G16H 40/40 (20180101) G16H 40/60 (20180101) G16H 40/67 (20180101) G16H 50/30 (20180101) G16H 80/00 (20180101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/30 (20130101) H04L 9/088 (20130101) H04L 63/101 (20130101) H04L 67/34 (20130101) Wireless Communication Networks H04W 76/10 (20180201) H04W 76/14 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135454 | Xu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Zhen Xu (Ann Arbor, Michigan); Jonathan Sukovich (Ann Arbor, Michigan); Aditya S. Pandey (Ann Arbor, Michigan); Charles A. Cain (Ann Arbor, Michigan); Hitinder S. Gurm (Ann Arbor, Michigan) |
| ABSTRACT | A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient. |
| FILED | Thursday, June 23, 2016 |
| APPL NO | 15/737761 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/00 (20130101) A61N 7/02 (20130101) Original (OR) Class A61N 2007/003 (20130101) A61N 2007/0039 (20130101) A61N 2007/0047 (20130101) A61N 2007/0065 (20130101) A61N 2007/0078 (20130101) A61N 2007/0086 (20130101) A61N 2007/0095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135582 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178824 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 2400/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136234 | Burdea et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bright Cloud International Corp. (Highland Park, New Jersey) |
| ASSIGNEE(S) | Bright Cloud International Corporation (Highland Park, New Jersey) |
| INVENTOR(S) | Grigore C. Burdea (Highland Park, New Jersey); Nam Hun Kim (Paramus, New Jersey); Doru Tadeusz Roll (Long Beach, New York) |
| ABSTRACT | The present disclosure integrates an actuated tilting rehabilitation table, video tracking of the patient arm and opposite shoulder, a low-friction forearm support with grasping force sensing, remote data transmission and additional weighing means, one or more large displays, a computer and a plurality of simulation exercises, such as video games. The patient can be monitored by a local or remote clinician. The table tilts in order to increase exercise difficulty due to gravity loading on the patient's arm and shoulder. In one embodiment, the actuated tilting table tilts in four degrees of freedom. |
| FILED | Tuesday, January 16, 2018 |
| APPL NO | 15/872964 |
| ART UNIT | 3715 — Amusement and Education Devices |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/00 (20130101) Dispensing, Delivering or Transferring Liquids, Not Otherwise Provided for B67D 7/0227 (20130101) Original (OR) Class B67D 7/0238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136291 | Buhrlage et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Centre Hospitalier Universitaire Vaudois (Lausanne, Switzerland); The General Hospital Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); Centre Hospitalier Universitaire Vaudois (Lausanne, Switzerland); The General Hospital Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Sara Jean Buhrlage (Somerville, Massachusetts); Anders Näär (Arlington, Massachusetts); Gerhard Wagner (Brookline, Massachusetts); Haribabu Arthanari (Cambridge, Massachusetts); Joy Luz Nishikawa (Cambridge, Massachusetts); Andras Pal Boeszoermenyi (Boston, Massachusetts); Dominique Sanglard (Epalinges, Switzerland) |
| ABSTRACT | Provided herein are compounds (e.g., compounds of Formulae (I), (II), and (III)) which are anti-fungal agents and can be used in the treatment of diseases, including infectious diseases. The invention provides methods of treating diseases in a subject (e.g., infectious diseases such as fungal infections), and methods of killing or inhibiting the growth of fungi in or on a subject or biological sample. The compounds may be used in subjects, in clinical settings, or in agricultural settings. |
| FILED | Friday, February 17, 2017 |
| APPL NO | 15/998620 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) Acyclic or Carbocyclic Compounds C07C 335/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136297 | Shokat et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Kevan M. Shokat (San Francisco, California); Daniel Gentile (Darien, Connecticut); Steven Moss (San Francisco, California) |
| ABSTRACT | Disclosed herein, inter alia, are compositions and methods for modulating Ras and treating cancer. |
| FILED | Friday, December 15, 2017 |
| APPL NO | 16/468948 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 231/14 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) C12N 9/96 (20130101) Enzymes C12Y 306/05002 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136301 | Rana et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents Of The University Of California (Oakland, California); The University of Miami (Miami, Florida) |
| ASSIGNEE(S) | The Regents of the University of California, A California Corporation et al. (Oakland, California) |
| INVENTOR(S) | Tariq M. Rana (San Diego, California); Mario Stevenson (Miami, Florida) |
| ABSTRACT | Disclosed herein, inter alia, are agents having antiviral activity and methods of use thereof. |
| FILED | Wednesday, August 31, 2016 |
| APPL NO | 15/754877 |
| ART UNIT | 1699 — Organic Chemistry |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Heterocyclic Compounds C07D 249/06 (20130101) C07D 271/06 (20130101) C07D 271/07 (20130101) Original (OR) Class C07D 271/107 (20130101) C07D 413/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136312 | Witt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Southern Illinois University (Edwardsville, Illinois) |
| ASSIGNEE(S) | Board of Trustees of the Southern Illinois University (Edwardsville, Illinois) |
| INVENTOR(S) | Kenneth A. Witt (Edwardsville, Illinois); Albert M. Crider (Maryville, Illinois); William Neumann (St. Louis, Missouri); Audrey Hospital (Robbinsville, New Jersey); Karin Sandoval (Edwardsville, Illinois); Maria Kontoyianni (Glen Carbon, Illinois) |
| ABSTRACT | The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists. |
| FILED | Friday, May 11, 2018 |
| APPL NO | 16/613086 |
| ART UNIT | 1626 — Organic Chemistry |
| CURRENT CPC | Heterocyclic Compounds C07D 233/64 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 403/12 (20130101) C07D 403/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136316 | Spiegel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); Christopher Parker (Medina, Ohio) |
| ABSTRACT | The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 16/894362 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/496 (20130101) A61K 31/496 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Heterocyclic Compounds C07D 405/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136348 | Talley |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EMMYON, INC. (Coralville, Iowa) |
| ASSIGNEE(S) | EMMYON, INC. (Coralville, Iowa) |
| INVENTOR(S) | John J. Talley (St. Louis, Missouri) |
| ABSTRACT | Compounds of formula I are disclosed. The compounds are useful for promoting skeletal muscle hypertrophy or treating skeletal muscle atrophy. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 16/851648 |
| ART UNIT | 1627 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/343 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) A61P 21/06 (20180101) Heterocyclic Compounds C07D 307/77 (20130101) Steroids C07J 71/0005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136349 | MacMillan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF PRINCETON UNIVERSITY (Princeton, New Jersey) |
| INVENTOR(S) | David MacMillan (Princeton, New Jersey); Daniel Novoa (New York, New York); Stefan McCarver (Princeton, New Jersey) |
| ABSTRACT | Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside. |
| FILED | Friday, June 03, 2016 |
| APPL NO | 15/579741 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/181 (20130101) B01J 31/1815 (20130101) B01J 35/004 (20130101) B01J 2231/324 (20130101) B01J 2231/348 (20130101) B01J 2531/827 (20130101) B01J 2540/12 (20130101) B01J 2540/22 (20130101) B01J 2540/225 (20130101) Peptides C07K 1/107 (20130101) C07K 1/113 (20130101) Original (OR) Class C07K 5/0205 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/29 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136356 | Kwong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Peter Kwong (Washington, District of Columbia); John Mascola (Rockville, Maryland); Gwo-Yu Chuang (Rockville, Maryland); Hui Geng (Rockville, Maryland); Yongping Yang (Potomac, Maryland); Cheng Cheng (Bethesda, Maryland); Jeffrey Boyington (Clarksburg, Maryland); Yen-Ting Lai (Bethesda, Maryland) |
| ABSTRACT | Immunogens comprising a recombinant HIV-1 Env ectodomain trimer stabilized in a prefusion closed conformation and methods of their use and production are disclosed. In several embodiments, the immunogen can be used to elicit an immune response to HIV-1 in a subject. |
| FILED | Tuesday, October 16, 2018 |
| APPL NO | 16/756777 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 2039/64 (20130101) Peptides C07K 14/162 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136362 | Gross et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Eric Gross (Menlo Park, California); Carl Hurt (Stanford, California); Daria Mochly-Rosen (Menlo Park, California) |
| ABSTRACT | Methods of modulating the interaction between calcineurin and a calcineurin-binding protein partner are provided. Aspects of the methods include contacting a cell with a peptidic agent that modulates the interaction between calcineurin and a TRPV channel. Also provided are pharmaceutical compositions that comprise a peptidic agent that selectively modulates the interaction between calcineurin and a calcineurin-binding protein partner. Also provided are methods of treating a condition in a subject by selectively modulating the interaction between calcineurin and a calcineurin-binding TRPV channel. Also provided are screening methods to identify candidate agents that modulate calcineurin protein-protein interactions. |
| FILED | Wednesday, March 08, 2017 |
| APPL NO | 16/082313 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 9/0019 (20130101) A61K 38/00 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 41/00 (20180101) Peptides C07K 14/47 (20130101) Original (OR) Class C07K 2319/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136363 | Borkan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boston Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Boston Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Steven C. Borkan (Medfield, Massachusetts); Zhiyong Wang (Cambridge, Massachusetts) |
| ABSTRACT | One aspect of the technology relates to methods, assays and kits to identify ischemia and ischemic injury, including kidney injury, and are useful in determining efficacy of cancer treatments. In particular, differential phosphorylation of the nucleophosmin (NPM) polypeptide is an early marker of ischemic injuries such as kidney injury, AKI and ischemic renal cell injury. Another aspect of the technology relates to compositions and methods for the treatment of ischemia and kidney injury, including NPM inhibitory agents, including, but not limited to NPM inhibitory peptides for the treatment of ischemia and kidney injury. |
| FILED | Friday, February 01, 2019 |
| APPL NO | 16/265413 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 13/12 (20180101) Peptides C07K 14/47 (20130101) C07K 14/4703 (20130101) Original (OR) Class C07K 2319/09 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 33/6875 (20130101) G01N 33/54306 (20130101) G01N 2440/14 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136367 | Debinski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| INVENTOR(S) | Waldemar Debinski (Winston-Salem, North Carolina); Hetal Pandya (Winston-Salem, North Carolina); Denise Gibo (Winston-Salem, North Carolina) |
| ABSTRACT | A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described. |
| FILED | Thursday, December 05, 2019 |
| APPL NO | 16/704645 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/642 (20170801) Peptides C07K 14/005 (20130101) C07K 14/21 (20130101) C07K 14/34 (20130101) C07K 14/195 (20130101) C07K 14/5437 (20130101) Original (OR) Class C07K 19/00 (20130101) C07K 2319/01 (20130101) C07K 2319/09 (20130101) C07K 2319/74 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/532 (20130101) G01N 33/5008 (20130101) G01N 33/5091 (20130101) G01N 33/6869 (20130101) G01N 2333/025 (20130101) G01N 2333/195 (20130101) G01N 2333/5437 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136368 | Lathia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio) |
| ASSIGNEE(S) | THE CLEVELAND CLINIC FOUNDATION (Cleveland, Ohio) |
| INVENTOR(S) | Justin D. Lathia (Cleveland, Ohio); Ofer Reizes (Cleveland, Ohio) |
| ABSTRACT | Blocking peptides that inhibit FAK or NANOG binding to Cx26, and a method of treating cancer by administering these blocking peptides to a subject in need thereof are described. |
| FILED | Wednesday, August 23, 2017 |
| APPL NO | 16/326741 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/705 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136370 | Ruggeri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | The Scripps Research Institute (La Jolla, California) |
| INVENTOR(S) | Zaverio Ruggeri (La Jolla, California); Wolfram Ruf (San Diego, California); Yuichi Kamikubo (San Diego, California) |
| ABSTRACT | In various embodiments, disclosed herein are assays for measuring thrombin generated (TG) in a blood sample, comprising: incubating the blood sample with TF, FIXa, and CaCl2; and measuring TG in the blood sample. Also disclosed herein are assays for determining a bleeding risk in a subject, comprising obtaining a blood sample from the subject; adding to the blood sample TF and/or FIXa; determining the amount of coagulation factor VIII (FVIII:C) in the blood sample; and determining (a) a mild bleeding risk in the subject if the amount of FVIII:C in the sample is >5 IU/dL, (b) a moderate bleeding risk in the subject if the amount of FVIII:C in the sample is 1-5 IU/dL, and (c) a severe bleeding risk in the subject if the amount of FVIII:C in the subject is <1 IU/dL. |
| FILED | Friday, May 12, 2017 |
| APPL NO | 16/099977 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) Peptides C07K 14/745 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/644 (20130101) Enzymes C12Y 304/21022 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) G01N 2800/50 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136372 | Remaley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary, Dept. of Health and Human Services (Rockville, Maryland); Novo Nordisk A/S (Bagsvaerd, Denmark) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Rockville, Maryland); Novo Nordisk A/S (Bagsvaerd, Denmark) |
| INVENTOR(S) | Alan Thomas Remaley (Bethesda, Maryland); Soumitra Shanker Ghosh (San Diego, California); Madhav N. Devalaraja (Acton, Massachusetts); Chih-Hung Lo (Rockville, Maryland); Denis O. Sviridov (Rockville, Maryland); Anna Wolska (Washington, District of Columbia) |
| ABSTRACT | The disclosure provides apolipoprotein C-II (apoC-II) mimetic peptides and methods for treating hypertriglyceridemia in a patient with an effective amount of an apoC-II mimetic peptide. |
| FILED | Friday, January 19, 2018 |
| APPL NO | 16/479183 |
| ART UNIT | 1654 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/00 (20130101) A61K 38/1709 (20130101) A61K 38/1722 (20130101) Peptides C07K 14/775 (20130101) Original (OR) Class C07K 2317/53 (20130101) C07K 2319/21 (20130101) C07K 2319/41 (20130101) C07K 2319/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136377 | Roopenian et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JACKSON LABORATORY (Bar Harbor, Maine) |
| ASSIGNEE(S) | THE JACKSON LABORATORY (Bar Harbor, Maine) |
| INVENTOR(S) | Derry Roopenian (Salisbury Cove, Maine); Gregory Christianson (Seal Cove, Maine) |
| ABSTRACT | In certain embodiments, this present invention provides antibodies and Fc fusion proteins with enhanced pharmacokinetics, such as biotinylated antibodies or biotinylated Fc fusion polypeptides. |
| FILED | Monday, September 16, 2019 |
| APPL NO | 16/572003 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/557 (20170801) A61K 47/6835 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/00 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/72 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136383 | Springer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Timothy Alan Springer (Chestnut Hill, Massachusetts); Chafen Lu (Chestnut Hill, Massachusetts); Yan Qin (Andover, Massachusetts); Aiping Jiang (Brookline, Massachusetts) |
| ABSTRACT | Disclosed are compositions and methods for modulating the activity of TGF-β. More particularly, compositions and methods for modulating the release of active TGF-β from an LRRC33-TGF-β prodomain-TGF-β ternary complex are provided, as are and methods of treatment based upon such modulation. |
| FILED | Wednesday, October 25, 2017 |
| APPL NO | 16/344311 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/22 (20130101) Original (OR) Class C07K 16/28 (20130101) C07K 16/2818 (20130101) C07K 16/2863 (20130101) C07K 2317/20 (20130101) C07K 2317/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136402 | Badley |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Andrew D. Badley (Rochester, Minnesota) |
| ABSTRACT | This document provides antibodies against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) short, and more particularly to humanized TRAILshort antibodies that can neutralize TRAILshort. For example, materials and methods for using one or more humanized TRAILshort antibodies to induce apoptosis (e.g., via TRAIL mediated cell death, natural killer (NK) cytotoxicity, and/or CD8+ T cell killing) are provided. |
| FILED | Thursday, February 08, 2018 |
| APPL NO | 16/485056 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/191 (20130101) A61K 39/39558 (20130101) Peptides C07K 16/2875 (20130101) Original (OR) Class C07K 16/2878 (20130101) C07K 2317/24 (20130101) C07K 2317/73 (20130101) C07K 2317/75 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136410 | Kufe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); GENUS ONCOLOGY, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); GENUS ONCOLOGY, LLC (Chicago, Illinois) |
| INVENTOR(S) | Donald W. Kufe (Wellesley, Massachusetts); Surender Kharbanda (Natick, Massachusetts) |
| ABSTRACT | The present invention is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen. |
| FILED | Friday, July 06, 2018 |
| APPL NO | 16/028662 |
| ART UNIT | 1642 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) A61K 45/06 (20130101) A61K 47/6803 (20170801) A61K 47/6811 (20170801) A61K 47/6849 (20170801) A61K 47/6851 (20170801) A61K 47/6855 (20170801) A61K 47/6889 (20170801) Peptides C07K 16/2809 (20130101) C07K 16/3015 (20130101) C07K 16/3023 (20130101) C07K 16/3061 (20130101) C07K 16/3092 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/32 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136549 | Sentman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| INVENTOR(S) | Charles L. Sentman (Grantham, New Hampshire) |
| ABSTRACT | The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same. |
| FILED | Monday, April 10, 2017 |
| APPL NO | 15/483704 |
| ART UNIT | 1644 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/5156 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 2501/515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136553 | Yarmush et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Martin Yarmush (Newton, Massachusetts); Basak E. Uygun (Cambridge, Massachusetts); Korkut Uygun (Cambridge, Massachusetts); Maria-Louisa Izamis (Boston, Massachusetts); Alejandro Soto-Gutierrez (Boston, Massachusetts); Herman Tolboom (Zurich, Switzerland); Hiroshi Yagi (Brookline, Massachusetts); Carley Shulman (Sudbury, Massachusetts); Jack Milwid (Denver, Colorado) |
| ABSTRACT | One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ. |
| FILED | Tuesday, April 07, 2015 |
| APPL NO | 14/645527 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/021 (20130101) A01N 1/0247 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/407 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/067 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136554 | Melton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Douglas A. Melton (Lexington, Massachusetts); Qiao Zhou (Lexington, Massachusetts) |
| ABSTRACT | The present invention provides methods of reprogramming cells, for example, directly reprogramming a somatic cell of a first cell type into a somatic cell of a second cell type, are described herein. In particular, the present invention generally relates to methods for reprogramming a cell of an endoderm origin to a cell having pancreatic β-cell characteristics. The present invention also relates to an isolated population comprising reprogrammed cells, compositions and their use in the treatment of diabetes mellitus. In particular, the present invention relates to reprogramming a cell of an endoderm origin to a cell having pancreatic β-cell characteristics by increasing the protein expression of at least one transcription factor selected from Pdx1, Ngn3 or MafA in the cell of endoderm origin to reprogram the cell of an endoderm cell to a cell which exhibits at least one or at least two characteristics of an endogenous pancreatic β-cell. |
| FILED | Monday, March 04, 2019 |
| APPL NO | 16/292114 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/39 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0676 (20130101) Original (OR) Class C12N 2501/60 (20130101) C12N 2510/00 (20130101) C12N 2799/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136557 | Schaffer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | David V. Schaffer (Danville, California); Melissa A. Kotterman (Oakland, California); Bum-Yeol Hwang (Moraga, California); James T. Koerber (San Francisco, California) |
| ABSTRACT | The present disclosure provides infectious recombinant adeno-associated virus (rAAV) virions that comprise a variant capsid protein and a heterologous nucleic acid. The present disclosure further provides the variant adeno-associated virus (AAV) capsid proteins (and/or a nucleic acid encoding the variant AAV capsid proteins), which confer to an infectious rAAV virion an increased resistance to human AAV neutralizing antibodies. The present disclosure further provides host cells comprising an infectious rAAV virion and/or a nucleic acid encoding a subject variant AAV capsid protein. The present disclosure further provides methods of delivering a heterologous nucleic acid to a target cell where the target cell is contacted with a subject infectious rAAV virion. The present disclosure further provides methods of delivering a gene product to an individual, the methods generally involving administering an effective amount of a subject rAAV virion to an individual in need thereof. |
| FILED | Thursday, May 29, 2014 |
| APPL NO | 14/774972 |
| ART UNIT | 1633 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 35/761 (20130101) A61K 48/005 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/1058 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136558 | Mabashi-Asazuma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Wyoming (Laramie, Wyoming) |
| ASSIGNEE(S) | THE UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| INVENTOR(S) | Hideaki Mabashi-Asazuma (Laramie, Wyoming); Donald L. Jarvis (Laramie, Wyoming) |
| ABSTRACT | Compositions for reducing fucosylation of glycoproteins in insect cells are provided. Also disclosed are methods of use of such compositions for the production of recombinant humanized proteins. |
| FILED | Wednesday, February 27, 2019 |
| APPL NO | 16/287304 |
| ART UNIT | 1636 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 16/2887 (20130101) C07K 2317/14 (20130101) C07K 2317/24 (20130101) C07K 2317/41 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Enzymes C12Y 101/01281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136562 | Taunton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | John W. Taunton (San Francisco, California); Wendell A. Lim (San Francisco, California); Chia-Yung Wu (San Francisco, California) |
| ABSTRACT | The present disclosure provides conditionally active, heterodimeric polypeptides. The conditionally active, heterodimeric polypeptides are active in the presence of a dimerizing agent that induces dimerization of the polypeptides of the heterodimer. A conditionally active, heterodimeric polypeptide of the present disclosure is useful in a variety of research and treatment methods, which are also provided. |
| FILED | Wednesday, June 21, 2017 |
| APPL NO | 15/629235 |
| ART UNIT | 1646 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 1/36 (20130101) C07K 2/00 (20130101) C07K 14/72 (20130101) C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136574 | Jewett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Michael Christopher Jewett (Evanston, Illinois); Brian R. Fritz (Chicago, Illinois) |
| ABSTRACT | Disclosed are methods, components, compositions, and kits for preparing and identifying engineered E. coli ribosomes. The E. coli ribosomes may be prepared and identified under a set of defined conditions, such as in the presences of antibiotics, in order to obtain an engineered ribosome that is resistant to the antibiotic. |
| FILED | Monday, October 07, 2019 |
| APPL NO | 16/595438 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1041 (20130101) C12N 15/1058 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) C40B 40/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136580 | Lorson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| INVENTOR(S) | Christian Lorson (Columbia, Missouri); Erkan Osman (Columbia, Missouri) |
| ABSTRACT | The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject. |
| FILED | Monday, November 11, 2019 |
| APPL NO | 16/679763 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/3233 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136581 | Karthikeyan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Aiken, South Carolina) |
| INVENTOR(S) | Mythreye Karthikeyan (Columbia, South Carolina); Priyanka Singh (Columbia, South Carolina) |
| ABSTRACT | Contact of endothelial cells with inhibitors of inhibin and/or the alpha subunit of inhibin can be utilized to modify the activity of endothelial cell expression products including SMAD 1/5. Methods can also include inhibiting Alk1 and/or endoglin as components of inhibin-activated pathway of SMAD 1/5 signaling. Methods can be combined with other anti-angiogenesis therapies such as anti-VEGF therapies. Methods can be utilized in treatment of inhibin-expressing cancers (e.g., ovarian cancer, pancreatic cancer) as well as other pathologies such as preeclampsia and PCOS. |
| FILED | Friday, June 23, 2017 |
| APPL NO | 15/631561 |
| ART UNIT | 1647 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1136 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/14 (20130101) C12N 2310/531 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136595 | Salaita et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Khalid Salaita (Decatur, Georgia); Jessica Petree (Lawrenceville, Georgia); Kevin Yehl (Quincy, Massachusetts) |
| ABSTRACT | This disclosure relates to compositions comprising particles conjugated to one or more catalytically cleaving nucleic acids and optionally an RNA ligating enzyme. In certain embodiments, particles reported herein are used for splicing nucleic acid sequences. |
| FILED | Monday, November 05, 2018 |
| APPL NO | 16/180786 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/93 (20130101) C12N 15/52 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/902 (20130101) Original (OR) Class C12N 2310/127 (20130101) C12N 2320/33 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) Enzymes C12Y 301/00 (20130101) C12Y 605/01004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136597 | Saltzman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | W. Mark Saltzman (New Haven, Connecticut); Peter Glazer (Guilford, Connecticut); Raman Bahal (Hamden, Connecticut); Nicole Ali McNeer (Westport, Connecticut); Danith H. Ly (Pittsburgh, Pennsylvania); Elias Quijano (New Haven, Connecticut) |
| ABSTRACT | Compositions and methods for enhancing targeted gene editing and methods of use thereof are disclosed. In the most preferred embodiments, gene editing is carried out utilizing a gene editing composition such as triplex-forming oligonucleotides, CRISPR, zinc finger nucleases, TALENS, or others, in combination with a gene modification potentiating agent such as stem cell factor (SCF), a CHK1 or ATR inhibitor, or a combination thereof. A particular preferred gene editing composition is triplex-forming peptide nucleic acids (PNAs) substituted at the γ position for increased DNA binding affinity. Nanoparticle compositions for intracellular delivery of the gene editing composition are also provided and particular advantageous for use with in vivo applications. |
| FILED | Thursday, February 16, 2017 |
| APPL NO | 15/434978 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1647 (20130101) A61K 48/005 (20130101) Peptides C07K 14/003 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/15 (20130101) C12N 2310/152 (20130101) C12N 2310/318 (20130101) C12N 2310/334 (20130101) C12N 2310/351 (20130101) C12N 2310/3181 (20130101) C12N 2310/3519 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136614 | Messner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Jacob Messner (Mesa, Arizona); Clifford Anderson (Tempe, Arizona); Honor Glenn (Mesa, Arizona); Kristen Lee (Mesa, Arizona); Mark Richards (Chandler, Arizona); Laimonas Kelbauskas (Gilbert, Arizona); Kimberly Bussey (Phoenix, Arizona); Deirdre Meldrum (Phoenix, Arizona) |
| ABSTRACT | Methods for seeding live cells onto spatially defined regions of a substrate including multiple features (e.g., microwells or other microenvironments) utilize a stencil embodied in a hole-defining sacrificial film. A sacrificial film devoid of holes may be applied over features of a substrate, and a hole generating mechanism (e.g., hot needle or laser) aligned with features may be used to define holes in the film. Alternatively, holes may be predefined in a sacrificial film to form a stencil, and the stencil may be assembled to the substrate with the holes registered with features thereof. Thereafter, cells are seeded through holes in the film. Seeded cells are subject to incubation, further processing, and/or performance of one or more assays, and the hole-defining sacrificial film (stencil) may be removed. |
| FILED | Friday, October 07, 2016 |
| APPL NO | 15/757712 |
| ART UNIT | 1651 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 1/00 (20130101) C12M 23/12 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/24 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56966 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136620 | Klapperich et al. |
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| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts) |
| INVENTOR(S) | Catherine M. Klapperich (Brookline, Massachusetts); Natalia M. Rodriguez (West Lafayette, Indiana); Jacqueline C. Linnes (West Lafayette, Indiana) |
| ABSTRACT | The invention features a fully-integrated rapid molecular diagnostic device that is low-cost, easy to manufacture, and simple to use. The device can serve as a molecular diagnostic platform for any disease, requiring little or no preparation or customization and can be made from simple materials (e.g., paper and adhesive film), making it inexpensive, portable, and disposable. The invention also provides methods of using the device for detection of one or more targets in a sample. |
| FILED | Monday, December 12, 2016 |
| APPL NO | 16/061129 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 2300/0816 (20130101) B01L 2300/0825 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6844 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/558 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136626 | Sharp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Frank Sharp (Davis, California); Glen C. Jickling (Sacramento, California) |
| ABSTRACT | This invention provides gene expression profiles useful for diagnosing lacunar stroke and for distinguishing lacunar stroke from non-lacunar stroke. |
| FILED | Thursday, December 20, 2018 |
| APPL NO | 16/228030 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2800/2871 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136629 | Markowitz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | Case Western Reserve University (Cleveland, Ohio) |
| INVENTOR(S) | Sanford D. Markowitz (Pepper Pike, Ohio); Joseph Willis (Shaker Heights, Ohio); Amitabh Chak (University Heights, Ohio); Rom Leidner (Portland, Oregon) |
| ABSTRACT | This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder. |
| FILED | Monday, September 09, 2019 |
| APPL NO | 16/564392 |
| ART UNIT | 1637 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/136 (20130101) C12Q 2600/154 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137375 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Lihong V. Wang (Creve Coeur, Missouri); Lidai Wang (St. Louis, Missouri); Chi Zhang (St. Louis, Missouri); Puxiang Lai (St. Louis, Missouri); Jian Wei Tay (St. Louis, Missouri) |
| ABSTRACT | Systems and methods for focusing a light pulse within a focus area using nonlinear photoacoustic wavefront shaping (PAWS) are disclosed herein. The method includes modulating a spatial phase pattern of a light pulse's waveform based on a Grueneisen-relaxation photoacoustic (GR-PA) feedback signal. In addition, systems and methods for performing Grueneisen-relaxation photoacoustic microscopy (GR-PAM) are disclosed herein that include analyzing photoacoustic signals resulting from illumination of a focus region by two closely spaced light pulses. A method of obtaining an absorption coefficient of a sample using Grueneisen-relaxation photoacoustic microscopy (GR-PAM) is also disclosed. |
| FILED | Wednesday, November 19, 2014 |
| APPL NO | 15/037468 |
| ART UNIT | 1631 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/2418 (20130101) Original (OR) Class G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 21/002 (20130101) G02B 21/0004 (20130101) G02B 21/008 (20130101) G02B 21/0028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137384 | Yoon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University Of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Jeong-Yeol Yoon (Tucson, Arizona); Robin E. Sweeney (Tucson, Arizona) |
| ABSTRACT | The invention relates to methods and devices to identify an infection via light scatter from a tissue surface. |
| FILED | Monday, April 10, 2017 |
| APPL NO | 15/483723 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0075 (20130101) A61B 5/0077 (20130101) A61B 5/0082 (20130101) A61B 5/441 (20130101) A61B 5/6898 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/47 (20130101) G01N 33/4833 (20130101) Original (OR) Class G01N 2021/4704 (20130101) G01N 2021/4711 (20130101) G01N 2021/4735 (20130101) G01N 2333/31 (20130101) G01N 2333/245 (20130101) G01N 2333/255 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137386 | Gyarfas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Brett Gyarfas (Chandler, Arizona); Stuart Lindsay (Phoenix, Arizona); Pei Pang (Tempe, Arizona) |
| ABSTRACT | Embodiments of the disclosure are directed to a device for molecule sensing. In some embodiments, the device includes a first electrode separated from a second electrode by a dielectric layer. The first electrode comprises a large area electrode and the second electrode comprises a small area electrode. At least one opening (e.g., trench) cut or otherwise created into the dielectric layer exposes a tunnel junction therebetween whereby target molecules in solution can bind across the tunnel junction. |
| FILED | Friday, April 19, 2019 |
| APPL NO | 16/389898 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) G01N 33/48721 (20130101) Original (OR) Class Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137394 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Pengyu Chen (Ann Arbor, Michigan); Katsuo Kurabayashi (Ann Arbor, Michigan); Timothy T. Cornell (Ann Arbor, Michigan); Thomas P. Shanley (Ann Arbor, Michigan); Meng Ting Chung (Ann Arbor, Michigan); Yujing Song (Ann Arbor, Michigan); Walker M. McHugh (Dexter, Michigan) |
| ABSTRACT | Provided herein are systems and methods for assays. In particular, provided herein are systems and methods for performing high throughput immunoassays. Embodiments of the present disclosure provide multiplex capable LSPR immunoassays that meet a need for rapid (e.g., near real time), accurate immunoassays (e.g. for use in beside diagnostics). The LSPR assays are as accurate as existing ELISA assays but provide the advantage of increased speed and multiplex capability. In addition, the LSPR immunoassays are able to analyze small volumes of complex patient samples (e.g., serum). |
| FILED | Tuesday, February 16, 2016 |
| APPL NO | 15/551164 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 2300/123 (20130101) B01L 2300/161 (20130101) B01L 2300/0636 (20130101) B01L 2300/0645 (20130101) B01L 2300/0816 (20130101) B01L 2300/0861 (20130101) B01L 2300/0877 (20130101) B01L 2400/043 (20130101) B01L 2400/0406 (20130101) B01L 2400/0415 (20130101) B01L 2400/0442 (20130101) B01L 2400/0457 (20130101) B01L 2400/0487 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54346 (20130101) G01N 33/54373 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137399 | Hung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Chiung-Yu Hung (San Antonio, Texas); Jieh-Juen Yu (San Antonio, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Chiung-Yu Hung (San Antonio, Texas); Jieh-Juen Yu (San Antonio, Texas) |
| ABSTRACT | Composition and methods for detection of Coccidioidomycosis. |
| FILED | Thursday, September 26, 2019 |
| APPL NO | 16/583486 |
| ART UNIT | 1645 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Peptides C07K 16/40 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 15/80 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/56961 (20130101) Original (OR) Class G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137400 | Ouyang |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Hongjiao Ouyang (Plano, Texas) |
| ABSTRACT | The present disclosure relates to methods for predicting and/or determining responsiveness to an activator of JNK kinase activity. The present disclosure further relates to improved methods for treating a cancer patient with an activator of JNK kinase activity. The present disclosure also relates to methods for screening for a modulator of XBP1s protein phosphorylation. |
| FILED | Friday, June 29, 2018 |
| APPL NO | 16/626488 |
| ART UNIT | 1629 — Organic Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/573 (20130101) A61K 31/4965 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/57407 (20130101) Original (OR) Class G01N 2440/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137408 | Apte et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Rajendra S. Apte (St. Louis, Missouri); Jun Yoshino (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provided methods for determining the severity of glaucoma using the expression levels of GDF15. Determining the severity of glaucoma aids in treatment decisions. |
| FILED | Monday, January 30, 2017 |
| APPL NO | 16/073726 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Peptides C07K 14/475 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2333/52 (20130101) G01N 2800/52 (20130101) G01N 2800/168 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137409 | Chapman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Michael P. Chapman (Denver, Colorado); Hunter B. Moore (Denver, Colorado); Eduardo Gonzalez Barreda (Denver, Colorado); Ernest E. Moore (Denver, Colorado) |
| ABSTRACT | In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis. In some embodiments, the invention also provides a container adapted for detecting an aberrant fibrinolysis condition in a blood sample using viscoelastic analysis comprising an interior having a coating comprising a thrombolytic agent. |
| FILED | Thursday, November 05, 2015 |
| APPL NO | 15/524095 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/36 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/56 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) Original (OR) Class G01N 2800/224 (20130101) G01N 2800/226 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137410 | Kalantar-Zedeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Quest Diagnostics Investments LLC (Secaucus, New Jersey); Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center (LA BioMed) (Torrance, California) |
| ASSIGNEE(S) | Quest Diagnostics Investments LLC (Secaucus, New Jersey); Los Angeles Biomedical Research Institute (Torrance, California) |
| INVENTOR(S) | Kamyar Kalantar-Zedeh (Torrance, California); Michael P. Caulfield (Oceanside, California); Wael A. Salameh (San Juan Capistrano, California) |
| ABSTRACT | Described herein are methods for determining the overall survival of maintenance hemodialysis patients. The methods include measuring low density lipoprotein (LDL) particle size and subfraction concentrations as prognostic tools for early mortality risk detection. For example, the presence of increased very small LDL concentration or decreased LDL particle size in blood-serum serves as a useful means for prognostic risk assessment and monitoring. |
| FILED | Tuesday, October 29, 2019 |
| APPL NO | 16/667061 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 2800/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137462 | Shapiro et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan) |
| INVENTOR(S) | Erik Shapiro (Okemos, Michigan); Muhammad Jamal Afridi (Woodbury, Minnesota); Arun Ross (East Lansing, Michigan); Xiaoming Liu (Okemos, Michigan) |
| ABSTRACT | A system and method are provided for tracking magnetically-labeled substances, such as transplanted cells, in subjects using magnetic resonance imaging (MRI). The method includes obtaining a quantity of a substance that comprises an MRI contrast compound or is otherwise magnetically-labeled for purposes of an MRI scan, administering the substance into a region of interest of a subject, performing an imaging scan of a portion of the subject comprising the region of interest, obtaining an imaging data set from the scan, reducing the dataset into pixel groupings based on intensity profiles, where the pixel groupings have a pixel size larger than the expected pixel size of a unit of the MRI contrast compound or magnetically-labeled substance, extracting candidate pixel matrices from the imaging data, training a machine learning (ML) module by using the candidate pixel matrices, quantifying the presence, number and/or location of units of the substance within the subject by using the ML module, and displaying a visual representation of an identification of the substances within the subject as a result of using the ML module. |
| FILED | Monday, June 12, 2017 |
| APPL NO | 15/620545 |
| ART UNIT | 3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) A61B 5/742 (20130101) A61B 5/7267 (20130101) A61B 5/7475 (20130101) A61B 2576/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/1896 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/546 (20130101) G01R 33/5601 (20130101) Original (OR) Class G01R 33/5608 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0014 (20130101) G06K 9/00147 (20130101) G06K 9/6273 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137467 | Ennis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Daniel Ennis (Manhattan Beach, California); Eric Aliotta (Los Angeles, California); Kevin Moulin (Los Angeles, California) |
| ABSTRACT | A system and method for optimized diffusion-weighted imaging is provided. In one aspect, the method includes providing a plurality of constraints comprising an eddy current constraint for imaging a target at a selected diffusion weighting, and applying an optimization framework to generate an optimized diffusion encoding gradient waveform satisfying the plurality of constraints. The method also includes performing, using the MRI system, a pulse sequence comprising the optimized diffusion encoding gradient waveform to generate diffusion-weighted data, and generating at least one image of the target using the diffusion-weighted data. |
| FILED | Thursday, March 01, 2018 |
| APPL NO | 16/488972 |
| ART UNIT | 2852 — Printing/Measuring and Testing |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/543 (20130101) G01R 33/5616 (20130101) G01R 33/56341 (20130101) Original (OR) Class G01R 33/56518 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11138768 | Helm et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Medtronic Navigation, Inc. (Louisville, Colorado); Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | Medtronic Navigation, Inc. (Louisville, Colorado); Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Patrick A. Helm (Milton, Massachusetts); Jeffrey H. Siewerdsen (Baltimore, Maryland); Ali Uneri (Baltimore, Maryland); Wojciech Zbijewski (Baltimore, Maryland); Xiaoxuan Zhang (Baltimore, Maryland); Joseph W. Stayman, IV (Baltimore, Maryland) |
| ABSTRACT | Selected artifacts, which may be based on distortions or selected attenuation features, may be reduced or removed from a reconstructed image. Various artifacts may occur due to the presence of a metal object in a field of view. The metal object may be identified and removed from a data that is used to generate a reconstruction. |
| FILED | Thursday, April 04, 2019 |
| APPL NO | 16/375292 |
| ART UNIT | 2665 — Image Analysis; Applications; Pattern Recognition; Color and compression; Enhancement and Transformation |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/5282 (20130101) A61B 34/10 (20160201) A61B 90/37 (20160201) A61B 2034/102 (20160201) A61B 2090/376 (20160201) A61B 2090/3764 (20160201) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/005 (20130101) G06T 7/60 (20130101) G06T 11/006 (20130101) Original (OR) Class G06T 2207/10124 (20130101) G06T 2207/20081 (20130101) G06T 2207/20182 (20130101) G06T 2207/20221 (20130101) G06T 2207/30052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139853 | Eletreby et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Rashad Eletreby (Pittsburgh, Pennsylvania); Swarun Kumar (Pittsburgh, Pennsylvania); Osman Yagan (Pittsburgh, Pennsylvania); Diana Zhang (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described herein is a system that overcomes challenges pertaining to density and range of urban LP-WANs despite the limited capabilities of base station and client hardware. The invention proposes a novel technique that aims to disentangle and decode large numbers of interfering transmissions at a simple, single-antenna LP-WAN base station by exploiting the hardware imperfections of low-cost LP-WAN clients to its advantage Second, the present invention exploits the correlation of sensed data collected by LP-WAN nodes to collaboratively reach a far-away base station, even if individual clients are beyond its range. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/053406 |
| ART UNIT | 2632 — Digital Communications |
| CURRENT CPC | Transmission H04B 1/69 (20130101) Original (OR) Class H04B 2001/6912 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0202 (20130101) H04L 27/103 (20130101) H04L 27/144 (20130101) H04L 27/265 (20130101) Wireless Communication Networks H04W 52/0209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 11135280 | Aman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTEGRATED BIOTHERAPEUTICS, INC. (Rockville, Maryland); INTEGRAL MOLECULAR, INC. (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | INTEGRATED BIOTHERAPEUTICS, INC. (Rockville, Maryland); INTEGRAL MOLECULAR, INC. (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Mohammad Javad Aman (Rockville, Maryland); Katie A. Howell (North Bethesda, Maryland); Edgar Davidson (Philadelphia, Pennsylvania); Benjamin J. Doranz (Drexel Hill, Pennsylvania) |
| ABSTRACT | Provided herein are methods of incorporating substitutions of specified residues into a filovirus GP in order to increase immunogenicity and/or broaden the cross-reactivity of the protective immune response against other filovirus members. Also provided herein are mutant filovirus GPs comprising such substitutions. |
| FILED | Monday, March 27, 2017 |
| APPL NO | 16/084151 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2760/14122 (20130101) C12N 2760/14134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135555 | Griggs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY (Alexandria, Virginia) |
| ASSIGNEE(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY (Alexandria, Virginia) |
| INVENTOR(S) | Christopher S. Griggs (Vicksburg, Mississippi); Jose A. Mattei-Sosa (Vicksburg, Mississippi); Luke A. Gurtowski (Vicksburg, Mississippi); Lauren F. Greenlee (Fayetteville, Arkansas); Mojtaba Abolhassani (Yazd, Iran) |
| ABSTRACT | This invention relates generally to a chitosan-graphene oxide membrane and process of making the same. The nanocomposite membrane can filter water and remove contaminants without fouling like other commercially-available polymer-based water filters. The membrane can be used as a flat sheet filter or can be engineered in a spiral filtration module. The membrane is scalable and tunable for many water contaminants including pharmaceuticals, pesticides, herbicides, and other organic chemicals. The membrane uses chitosan, which is low-cost, renewable biopolymer typically considered to be a waste product and the second most abundant biopolymer on Earth, thus making the membrane an environmentally-friendly product choice. |
| FILED | Tuesday, March 17, 2020 |
| APPL NO | 16/821477 |
| ART UNIT | 1736 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Separation B01D 63/10 (20130101) B01D 67/0011 (20130101) B01D 67/0013 (20130101) B01D 67/0079 (20130101) B01D 69/02 (20130101) B01D 69/06 (20130101) B01D 69/148 (20130101) Original (OR) Class B01D 71/08 (20130101) B01D 71/021 (20130101) B01D 71/024 (20130101) B01D 2315/10 (20130101) B01D 2325/28 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) C02F 2101/306 (20130101) C02F 2101/308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135564 | Leventis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aspen Aerogels, Inc. (Northborough, Massachusetts) |
| ASSIGNEE(S) | Aspen Aerogels, Inc. (Northborough, Massachusetts) |
| INVENTOR(S) | Nicholas Leventis (Worcester, Massachusetts); Chariklia Sotiriou-Leventis (Rolla, Missouri); Malik Adnan Saeed (Rolla, Missouri) |
| ABSTRACT | The present invention discloses novel porous polymeric compositions comprising random copolymers of amides, imides, ureas, and carbamic-anhydrides, useful for the synthesis of monolithic bimodal microporous/macroporous carbon aerogels. It also discloses methods for producing said microporous/macroporous carbon aerogels by the reaction of a polyisocyanate compound and a polycarboxylic acid compound, followed by pyrolytic carbonization, and by reactive etching with CO2 at elevated temperatures. Also disclosed are methods for using the microporous/macroporous carbon aerogels in the selective capture and sequestration of carbon dioxide. |
| FILED | Thursday, March 23, 2017 |
| APPL NO | 15/466968 |
| ART UNIT | 1776 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Separation B01D 53/02 (20130101) B01D 2253/102 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0065 (20130101) B01J 13/0091 (20130101) B01J 20/20 (20130101) Original (OR) Class B01J 20/3078 (20130101) B01J 20/3085 (20130101) B01J 20/28042 (20130101) B01J 20/28047 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/00 (20170801) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/346 (20130101) C08G 18/7664 (20130101) C08G 2110/0091 (20210101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/36 (20130101) C08J 9/286 (20130101) C08J 2201/0543 (20130101) C08J 2205/05 (20130101) C08J 2205/026 (20130101) C08J 2205/044 (20130101) C08J 2205/048 (20130101) C08J 2375/02 (20130101) C08J 2375/04 (20130101) C08J 2377/00 (20130101) C08J 2379/08 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 3/104 (20130101) C10L 2290/542 (20130101) Capture, Storage, Sequestration or Disposal of Greenhouse Gases [GHG] Y02C 20/20 (20130101) Y02C 20/40 (20200801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135582 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178824 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 2400/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135583 | Landers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | James P. Landers (Charlottesville, Virginia); Jacquelyn A. DuVall (Raleigh, North Carolina); Delphine Le Roux (Barboursville, Virginia); Brian Root (Charlottesville, Virginia); Daniel Mills (Charlottesville, Virginia); Daniel A. Nelson (Charlottesville, Virginia); An-Chi Tsuei (Charlottesville, Virginia); Brandon L. Thompson (Charlottesville, Virginia); Jingyi Li (Charlottesville, Virginia); Christopher Birch (Charlottesville, Virginia) |
| ABSTRACT | A method to extract, amplify and separate nucleic acid in a microfluidic device having a plurality of chambers and channels can include a) introducing cells having nucleic acid to a first chamber of the microfluidic device and subjecting the cells in the first chamber to conditions that lyse the cells. The method can further include b) subjecting the first chamber to centrifugal force, thereby allowing the lysate or a portion thereof having nucleic acid to be distributed to a second chamber through a first channel in the microfluidic device. The method can also include c) combining the lysate or the portion thereof and reagents for amplification of the nucleic acid, thereby providing a second mixture. The method can also include d) subjecting the second chamber to centrifugal force, thereby allowing gas to be expelled from the second mixture. |
| FILED | Thursday, October 13, 2016 |
| APPL NO | 15/768115 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 3/502753 (20130101) B01L 7/52 (20130101) B01L 2200/10 (20130101) B01L 2200/12 (20130101) B01L 2200/16 (20130101) B01L 2200/0621 (20130101) B01L 2200/0647 (20130101) B01L 2200/0684 (20130101) B01L 2300/0803 (20130101) B01L 2300/0816 (20130101) B01L 2300/0887 (20130101) B01L 2300/1822 (20130101) B01L 2300/1844 (20130101) B01L 2400/0409 (20130101) B01L 2400/0421 (20130101) B01L 2400/0424 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/00 (20130101) G01N 21/07 (20130101) G01N 27/447 (20130101) G01N 27/44791 (20130101) G01N 2201/064 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135594 | Glezer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Meso Scale Technologies, LLC. (Rockville, Maryland) |
| ASSIGNEE(S) | MESO SCALE TECHNOLOGIES, LLC. (Rockville, Maryland) |
| INVENTOR(S) | Eli N. Glezer (Del Mar, California); Bandele Jeffrey-Coker (Darnestown, Maryland); Kenneth Page (Germantown, Maryland); Sandor Kovacs (Middletown, Delaware); Sudeep Kumar (Gaithersburg, Maryland); Kristian Roth (Germantown, Maryland) |
| ABSTRACT | Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed. |
| FILED | Tuesday, March 05, 2019 |
| APPL NO | 16/292521 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) B01L 3/567 (20130101) Original (OR) Class B01L 3/5085 (20130101) B01L 3/502738 (20130101) B01L 2300/0681 (20130101) B01L 2300/0816 (20130101) B01L 2300/0867 (20130101) B01L 2300/0874 (20130101) B01L 2400/0487 (20130101) B01L 2400/0622 (20130101) B01L 2400/0644 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 11/0743 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/2575 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136574 | Jewett et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Michael Christopher Jewett (Evanston, Illinois); Brian R. Fritz (Chicago, Illinois) |
| ABSTRACT | Disclosed are methods, components, compositions, and kits for preparing and identifying engineered E. coli ribosomes. The E. coli ribosomes may be prepared and identified under a set of defined conditions, such as in the presences of antibiotics, in order to obtain an engineered ribosome that is resistant to the antibiotic. |
| FILED | Monday, October 07, 2019 |
| APPL NO | 16/595438 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1041 (20130101) C12N 15/1058 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) C40B 40/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136991 | Ditomasso et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| INVENTOR(S) | John C. Ditomasso (Glastonbury, Connecticut); Matthew P. Forcier (South Windsor, Connecticut) |
| ABSTRACT | A tandem rotor disk apparatus may include a rotor disk body concentric about an axis. The tandem rotor disk apparatus may also include a first blade extending radially outward of the rotor disk body and a second blade extending radially outward of the rotor disk body. The first blade may be offset from the second blade in a direction parallel to the axis. The tandem rotor disk apparatus may be implemented in a gas turbine engine with no intervening stator vane stages disposed between the first blade and the second blade. The tandem rotor disk apparatus may include two separate rotor disk bodies. |
| FILED | Monday, May 04, 2020 |
| APPL NO | 16/866303 |
| ART UNIT | 3747 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/34 (20130101) F01D 5/142 (20130101) F01D 5/146 (20130101) F01D 5/3007 (20130101) F01D 5/3038 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) Non-positive-displacement Pumps F04D 19/02 (20130101) F04D 29/321 (20130101) F04D 29/322 (20130101) F04D 29/324 (20130101) Original (OR) Class F04D 29/644 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137032 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bell Textron Inc. (Fort Worth, Texas); United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | Bell Textron Inc. (Fort Worth, Texas); United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Cody Anderson (Lantana, Texas); Gilberto Morales (Arlington, Texas); Lawrence Mark Zunski (Hayes, Virginia) |
| ABSTRACT | An example of a ceramic bearing system includes a shaft comprising two radially extending shoulders that define a channel therebetween, a first tolerance ring disposed in the channel of the shaft, and a bearing assembly comprising a ceramic bearing. The bearing assembly is positioned around the first tolerance ring and has an axial length that is longer than an axial length of the first tolerance ring. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 16/887526 |
| ART UNIT | 3656 — Material and Article Handling |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/06 (20130101) Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 19/04 (20130101) F16C 19/18 (20130101) F16C 33/583 (20130101) F16C 35/067 (20130101) F16C 35/073 (20130101) F16C 37/007 (20130101) Original (OR) Class F16C 2202/22 (20130101) F16C 2206/40 (20130101) F16C 2226/10 (20130101) F16C 2326/43 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137220 | Allred et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Taylor Phillip Allred (West Lafayette, Indiana); Justin A. Weibel (West Lafayette, Indiana); Suresh V. Garimella (West Lafayette, Indiana) |
| ABSTRACT | Systems and methods that utilize enhanced boiling surfaces to promote the efficiency of boiling. Such a system has a surface that is hydrophobic and exhibits a sufficiently low receding contact angle to a liquid such that vapor spreading during bubble growth and premature transition to film boiling is mitigated. |
| FILED | Tuesday, June 18, 2019 |
| APPL NO | 16/444155 |
| ART UNIT | 3763 — Refrigeration, Vaporization, Ventilation, and Combustion |
| CURRENT CPC | Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/187 (20130101) Original (OR) Class F28F 2245/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137237 | Flater, IV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | US Govt as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | United States of America as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Philip J. Flater, IV (Niceville, Florida); Charles M. Jenkins (Fort Walton Beach, Florida) |
| ABSTRACT | A device includes a cylindrical lattice structure inside of a cylindrical tube. The cylindrical lattice structure includes compartmentalized one or more longitudinal flowable paths formed by an additive manufacturing process. A material is introduced in a flowable state into one or more upper apertures of the one or more longitudinal flowable paths to fill the cylindrical lattice structure in a compartmentalized arrangement that provides stiffness to the device. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/029476 |
| ART UNIT | 3641 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 12/208 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137250 | Wen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Haoran Wen (Atlanta, Georgia); Farrokh Ayazi (Atlanta, Georgia) |
| ABSTRACT | A bulk acoustic wave resonator apparatus includes a resonator member, at least one anchor structure coupling the resonator member to a substrate, and a comb-drive element connected to the resonator member. The comb-drive element includes first comb fingers protruding from the resonator member, and second comb fingers of a different material than the first comb fingers interdigitated with the first comb fingers to define sub-micron capacitive gaps therebetween. Respective sidewalls of the first comb fingers are oppositely-tapered relative to respective sidewalls of the second comb fingers along respective lengths thereof, such that operation of the comb-drive element varies the sub-micron capacitive gaps at the respective sidewalls thereof. Related devices and fabrication methods are also discussed. |
| FILED | Friday, October 28, 2016 |
| APPL NO | 15/771453 |
| ART UNIT | 2853 — Printing/Measuring and Testing |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 2201/033 (20130101) B81B 2203/0136 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/5677 (20130101) G01C 19/5684 (20130101) G01C 19/5698 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137287 | Arce et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | The United States of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Gonzalo R. Arce (Newark, Delaware); Chen Fu (San Jose, California); Michael L. Don (Baltimore, Maryland) |
| ABSTRACT | Systems, methods, architectures, mechanisms and/or apparatus configured to provide a compressive spectral imager for estimating a spectral image of a rotating scene such as a target scene as viewed from a spinning munition. |
| FILED | Friday, January 11, 2019 |
| APPL NO | 16/245390 |
| ART UNIT | 2877 — Optics |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0224 (20130101) G01J 3/0229 (20130101) Original (OR) Class G01J 3/2823 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137294 | Spangler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rolls-Royce Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | ROLLS-ROYCE CORPORATION (Indianapolis, Indiana) |
| INVENTOR(S) | Brian Thomas Spangler (Avon, Indiana); John V. Watkin (Franklin, Indiana); Timothy C. Keeney (Zionsville, Indiana); Neil James Dunaway (New Palestine, Indiana) |
| ABSTRACT | Systems and methods are provided to detect a failed thermocouple. A temperature in a gas path of a gas turbine engine may be measured, where the temperature is based on a signal generated by a thermocouple during a startup of the gas turbine engine and/or during an idle period that immediately follows the startup, and the thermocouple protrudes into the gas path. A failure of the thermocouple may be detected if the temperature is determined to be less than a threshold temperature. |
| FILED | Wednesday, February 21, 2018 |
| APPL NO | 15/901383 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/04 (20130101) G01K 7/021 (20130101) G01K 13/02 (20130101) G01K 13/024 (20210101) G01K 15/007 (20130101) Original (OR) Class G01K 2205/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137311 | Di Leo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Claudio V. Di Leo (Atlanta, Georgia); Mark F. Costello (Atlanta, Georgia); Benjamin Leon (Atlanta, Georgia); Julian Jose Rimoli (Atlanta, Georgia) |
| ABSTRACT | A sensing device includes a pressure sensor and a deformable cover. A fluid cavity engineered between the deformable cover and the pressure sensor changes shape and ultimately collapses as force is applied to the sensing device. The shape and collapse of the engineered cavity, along with the entire structure of deformable cover and the pressure sensor, govern the force vs. pressure behavior of the sensing device and can be tailored as desired. A first benefit includes providing tailored properties of the sensing device by varying the structure of the deformable cover. A second benefit includes that if too much force is applied, excess force—beyond that which is required to collapse the engineered cavity—does not produce excess pressure which would cause damage to the pressure sensor. As such the sensing device is protected from accidental, or intended, over loading. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 16/585162 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 19/0618 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137324 | Kesavan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Combat Capabilities Development Command, Chemical Biological Center (APG, Maryland) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Jana S Kesavan (Catonsville, Maryland); Jerold R. Bottiger (Aberdeen, Maryland) |
| ABSTRACT | A collection plate for a cascade impactor is provided that includes: a container; an absorbent layer including a bottom surface and a top surface, the absorbent layer residing within the container, the absorbent layer further including a liquid medium within the absorbent layer; and an impaction membrane placed on the top surface of the absorbent layer, such that the impaction membrane is in fluidic communication with the absorbent layer. The absorbent layer is configured to hydrate the impaction membrane for at least four hours in a temperature of about 78° F. at 37% RH. The collection plate may be utilized as a component in a cascade impactor and/or in a method of collecting a biological sample with a cascade impactor. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 16/844075 |
| ART UNIT | 2861 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2205 (20130101) G01N 1/2208 (20130101) Original (OR) Class G01N 15/0255 (20130101) G01N 2001/2223 (20130101) G01N 2015/0261 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137409 | Chapman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Michael P. Chapman (Denver, Colorado); Hunter B. Moore (Denver, Colorado); Eduardo Gonzalez Barreda (Denver, Colorado); Ernest E. Moore (Denver, Colorado) |
| ABSTRACT | In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis. In some embodiments, the invention also provides a container adapted for detecting an aberrant fibrinolysis condition in a blood sample using viscoelastic analysis comprising an interior having a coating comprising a thrombolytic agent. |
| FILED | Thursday, November 05, 2015 |
| APPL NO | 15/524095 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/36 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/56 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) Original (OR) Class G01N 2800/224 (20130101) G01N 2800/226 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137549 | Anderson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | Timothy C. Anderson (McKinney, Texas) |
| ABSTRACT | An optical fiber holder includes a first holder having a first upper surface and a first lower surface. The optical fiber holder is configured to be in contact with a working station through the first lower surface. Further, the optical fiber holder can include a second holder having a second upper surface and a second lower surface. The second holder can be operably attached to the first holder through the second lower surface. Also, the second holder is configured to rotate with respect to the first holder. Further, the optical fiber holder can include a third holder having plurality of holes therethrough configured to receive a respective plurality of optical fibers. The third holder can include a plurality of protrusions operably coupled to the second holder and configured to enable the third holder to move with respect to the second holder. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 16/663489 |
| ART UNIT | 2883 — Optics |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/3616 (20130101) Original (OR) Class G02B 6/3897 (20130101) G02B 6/4441 (20130101) G02B 6/4453 (20130101) G02B 6/4454 (20130101) G02B 6/4457 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137591 | Panas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Goverment of the United States, as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Robert Matthew Panas (Dublin, California); Harris J. Hall (Yellow Springs, Ohio); Lavern A. Starman (Dayton, Ohio) |
| ABSTRACT | The present disclosure relates to an imaging system which may make use of an electronic controller, a digital micromirror array, an aperture control system and a detector to image a desired scene. The digital micromirror array has a plurality of micromirror elements responsive to control signals generated by the electronic controller for electronically aiming the micromirror elements in a desired direction to image the desired area, and for receiving and reflecting light emanating from the desired area. The aperture control system receives light reflected from the digital micromirror array and passes a predetermined subportion of the received light therethrough. The detector is responsive to the predetermined subportion of light. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/817213 |
| ART UNIT | 2637 — Optical Communications |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 26/0833 (20130101) Original (OR) Class Transmission H04B 10/11 (20130101) H04B 10/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137778 | Streeter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| INVENTOR(S) | Alexander D. Streeter (Concord, New Hampshire); David E. Altobelli (Hollis, New Hampshire); N. Christopher Perry (Manchester, New Hampshire) |
| ABSTRACT | A control unit system. The system includes a control unit which includes a control unit charging interface, at least one magnet located proximate to the control unit charging interface, at least one actuator, a detachable manifold including at least one magnet, fluidly coupled to the at least one actuator, a pump connected to the at least one actuator for causing actuation thereof, and a control system for controlling the pump, wherein the control system controls the pump to actuate the at least one actuator at least in response to a signal received by the control system. The system also includes a recharging device configured to receive the control unit, the recharging device including a reed switch, wherein when the magnet in the control unit is located proximate to the reed switch, the switch is activated. |
| FILED | Monday, September 23, 2019 |
| APPL NO | 16/579186 |
| ART UNIT | 3774 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/7843 (20130101) A61F 5/012 (20130101) A61F 5/024 (20130101) A61F 5/34 (20130101) A61F 2002/704 (20130101) A61F 2002/741 (20130101) A61F 2002/745 (20130101) A61F 2002/5083 (20130101) A61F 2002/7635 (20130101) A61F 2002/7655 (20130101) A61F 2007/006 (20130101) A61F 2007/0063 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 39/00 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 7/0623 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11138063 | Diao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| INVENTOR(S) | Xiaoxu Diao (Columbus, Ohio); Carol Smidts (Columbus, Ohio); Chetan Mutha (Arlington, Virginia) |
| ABSTRACT | Systems and methods are provided for generating faults and analyzing fault propagation and its effects. Starting from the ontologies of components, functions, flows, and faults, systems and methods are provided that describe, generate and track faults in a computer system across multiple domains throughout design and/or development. In order to construct the system and fault models, a series of concepts is introduced in the form of ontologies and their dependencies. An investigation is performed into the faults, including their type, cause, life-cycle aspects, and effect. Principles and rules are created to generate various faults based on system configurations. After the modeling process, a simulation engine is described to execute actions and simulate the process of fault generation and propagation. As a result, fault paths that impact components and functions can be obtained. |
| FILED | Tuesday, July 07, 2020 |
| APPL NO | 16/922488 |
| ART UNIT | 2114 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 11/0721 (20130101) G06F 11/0793 (20130101) Original (OR) Class G06F 30/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11138492 | Esser et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Steven Kyle Esser (San Jose, California); Dharmendra S. Modha (San Jose, California); Anthony Ndirango (Berkeley, California) |
| ABSTRACT | Embodiments of the invention relate to canonical spiking neurons for spatiotemporal associative memory. An aspect of the invention provides a spatiotemporal associative memory including a plurality of electronic neurons having a layered neural net relationship with directional synaptic connectivity. The plurality of electronic neurons configured to detect the presence of a spatiotemporal pattern in a real-time data stream, and extract the spatiotemporal pattern. The plurality of electronic neurons are further configured to, based on learning rules, store the spatiotemporal pattern in the plurality of electronic neurons, and upon being presented with a version of the spatiotemporal pattern, retrieve the stored spatiotemporal pattern. |
| FILED | Friday, November 11, 2016 |
| APPL NO | 15/349812 |
| ART UNIT | 2198 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/049 (20130101) Original (OR) Class G06N 3/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11138493 | Imaino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| INVENTOR(S) | Wayne I. Imaino (San Jose, California); Ahmet S. Ozcan (San Jose, California); J. Campbell Scott (San Jose, California) |
| ABSTRACT | Homeostasis-maintaining binary neural networks such as hierarchical temporal memories are provided. In various embodiments, a region of an artificial neural network is initialized. The region comprises a plurality of neurons and has a permanence value associated with each potential synaptic connection between neurons. The initialization comprises connecting a subset of the potential synaptic connections by synapses. A plurality of time-ordered inputs to the region is received. Some of the plurality of neurons are thereby caused to fire upon receipt of each time-ordered input. Upon receipt of each time-ordered input, for each potential synaptic connection between neurons, the permanence value is adjusted according to a firing sequence of the plurality of neurons. Those potential synaptic connections having a permanence value above a predetermined permanence threshold are connected when the total number of connected synapses in the region does not exceed a predetermined connectivity threshold. Synapses whose associated pre-synaptic neuron or post-synaptic neuron have more than a predetermined number of connected synapses are disconnected. |
| FILED | Friday, December 22, 2017 |
| APPL NO | 15/853280 |
| ART UNIT | 2827 — Semiconductors/Memory |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) Original (OR) Class G06N 3/063 (20130101) G06N 3/082 (20130101) G06N 3/088 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11138495 | Appuswamy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Rathinakumar Appuswamy (San Jose, California); Steven K. Esser (San Jose, California); Dharmendra S. Modha (San Jose, California) |
| ABSTRACT | Embodiments of the invention provide a method comprising receiving a set of features extracted from input data, training a linear classifier based on the set of features extracted, and generating a first matrix using the linear classifier. The first matrix includes multiple dimensions. Each dimension includes multiple elements. Elements of a first dimension correspond to the set of features extracted. Elements of a second dimension correspond to a set of classification labels. The elements of the second dimension are arranged based on one or more synaptic weight arrangements. Each synaptic weight arrangement represents effective synaptic strengths for a classification label of the set of classification labels. The neurosynaptic core circuit is programmed with synaptic connectivity information based on the synaptic weight arrangements. The core circuit is configured to classify one or more objects of interest in the input data. |
| FILED | Tuesday, August 21, 2018 |
| APPL NO | 16/107766 |
| ART UNIT | 2122 — AI & Simulation/Modeling |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) G06N 3/063 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11138520 | Ganti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| INVENTOR(S) | Raghu Kiran Ganti (Elmsford, New York); Mudhakar Srivatsa (White Plains, New York); Swati Rallapalli (Ossining, New York); Shreeranjani Srirangamsridharan (White Plains, New York) |
| ABSTRACT | An input dataset for training a new machine learning model is received by a processor. For each of a plurality of trained machine learning models, a hash function and a sketch of a training dataset used to train the machine learning model is retrieved. A sketch of the input dataset is computed based on the hash function and the input dataset, along with a distance between the sketch of the training dataset and the sketch of the input dataset. The computed distances of the trained machine learning models are ranked from smallest to largest, and a seed machine learning model for the input dataset is selected from the trained machine learning models based at least in part on the ranking. A training process of the new machine learning model using the selected seed machine learning model and the input dataset is initiated. |
| FILED | Thursday, June 28, 2018 |
| APPL NO | 16/021086 |
| ART UNIT | 2143 — Graphical User Interface and Document Processing |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 67/10 (20130101) H04L 67/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11138805 | Angelopoulos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Christopher James Angelopoulos (Navarre, Florida); Larry Clay Greunke (Seaside, California) |
| ABSTRACT | The invention relates to quantitative quality assurance in a mixed reality environment. In some embodiments, the invention includes using mixed reality sensors embedded in a mixed reality device to detect body positional movements of a user and using an indirect measuring device to determine a target location for the current state of the target equipment and a current subtask of a predefined workflow. The invention further includes using a direct measuring device associated with the target location to detect a user interaction by the user at the target location, determining a confidence value based on the user movements, the current subtask, and the user interaction, and displaying confirmation of the user interaction on a mixed reality display of the user. |
| FILED | Monday, October 19, 2020 |
| APPL NO | 17/074585 |
| ART UNIT | 2613 — Computer Graphic Processing, 3D Animation, Display Color Attribute, Object Processing, Hardware and Memory |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 27/0172 (20130101) Electric Digital Data Processing G06F 3/011 (20130101) G06F 3/017 (20130101) Image Data Processing or Generation, in General G06T 7/20 (20130101) G06T 7/70 (20170101) G06T 19/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11138817 | Martin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Charles E. Martin (Westlake Village, California); Tsai-Ching Lu (Thousand Oaks, California); Alice A. Murphy (Mesa, Arizona); Christopher R. Wezdenko (Mesa, Arizona); Steve Slaughter (Scottsdale, Arizona) |
| ABSTRACT | A method for determining a vehicle system prognosis includes detecting a predetermined characteristic of a vehicle with one or more sensors, receiving a plurality of sensor signals from the one or more sensors and determining an input time series of data based on the sensor signals, clustering a matrix of time series data, generated from the input time series of data, into a predetermined number of hyperplanes, extracting extracted features that are indicative of an operation of a vehicle system from a sparse temporal matrix based on data point behavior with respect to two or more hyperplanes within the sparse temporal matrix and determining an operational status of the vehicle system based on the extracted features, the sparse temporal matrix being based on the predetermined number of hyperplanes; and communicating the operational status of the vehicle system to an operator or crew member of the vehicle. |
| FILED | Tuesday, April 23, 2019 |
| APPL NO | 16/392048 |
| ART UNIT | 3665 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/4628 (20130101) G06K 9/6244 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 5/08 (20130101) G07C 5/085 (20130101) G07C 5/0808 (20130101) Original (OR) Class G07C 5/0841 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139086 | Howe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HOWE INDUSTRIES, LLC (Tempe, Arizona) |
| ASSIGNEE(S) | HOWE INDUSTRIES, LLC (Scottsdale, Arizona) |
| INVENTOR(S) | Troy M. Howe (Tempe, Arizona); Steven D. Howe (Tempe, Arizona) |
| ABSTRACT | A customizable thin plate fuel form and reactor core therefor are disclosed. The thin plate fuel will comprise a fuel material embedded within a matrix material, with the entire unit having a coating. The thin plate fuel may be flat or curved and will have flow channels formed within at least the top surface of the fuel plate. The structure of the thin plate fuel will make it easier for coating with Tungsten or any other suitable material that will help contain any byproducts, prevent reactions with the working fluid, and potentially provide structural support to the thin plate fuel. |
| FILED | Thursday, December 07, 2017 |
| APPL NO | 15/834922 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/408 (20130101) Nuclear Reactors G21C 3/20 (20130101) G21C 3/36 (20130101) Original (OR) Class G21C 3/64 (20130101) G21C 3/626 (20130101) G21C 5/16 (20130101) G21C 5/18 (20130101) G21C 5/126 (20130101) G21C 15/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139410 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Xiaobo Zhang (Arcadia, California); Kenneth M. Edmondson (Los Angeles, California); Daniel C. Law (Arcadia, California); Shoghig Mesropian (Tarzana, California) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Xiaobo Zhang (Arcadia, California); Kenneth M. Edmondson (Los Angeles, California); Daniel C. Law (Arcadia, California); Shoghig Mesropian (Tarzana, California) |
| ABSTRACT | A solar cell structure including a solar cell having a front surface and a back surface, a reflective layer disposed proximate the back surface and a flexible support layer disposed between the back surface and the reflective layer. |
| FILED | Tuesday, July 06, 2010 |
| APPL NO | 12/830670 |
| ART UNIT | 1726 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/054 (20141201) H01L 31/056 (20141201) Original (OR) Class H01L 31/0687 (20130101) H01L 31/03926 (20130101) H01L 31/06875 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139500 | Arugula et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CFD Research Corporation (Huntsville, Alabama) |
| ASSIGNEE(S) | CFD Research Corporation (Huntsville, Alabama) |
| INVENTOR(S) | Mary Arugula (Huntsville, Alabama); Erica Wagner Pinchon (Huntsville, Alabama); Sameer Singhal (Huntsville, Alabama) |
| ABSTRACT | An anode can include: an electrode substrate; a first region of the substrate having a catalyst composition located thereon, wherein the catalyst composition includes an inorganic or metallic catalyst; and a second region of the substrate having an enzyme composition located thereon, wherein the combination of the catalyst composition and enzyme composition converts a fuel reagent to carbon dioxide at neutral pH. The first region and second region can be separate regions. The catalyst of the catalyst composition can include gold nanoparticles. The catalyst can include an inorganic or metallic catalyst selected from vanadium oxide, titanium (III) chloride, Pd(OAc)2, MnO, zeolite, alumina, graphitic carbon, palladium, platinum, gold, ruthenium, rhodium, iridium, or combinations thereof. The catalyst can be nanoparticle, nanorod, nanodot, or combination thereof. The catalyst can have sizes that range from about 10 to 20 nm. |
| FILED | Monday, February 04, 2019 |
| APPL NO | 16/266956 |
| ART UNIT | 1725 — Fuel Cells, Battery, Flammable Gas, Solar Cells, Liquid Crystal Compositions |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0004 (20130101) C12N 11/14 (20130101) Enzymes C12Y 101/01001 (20130101) C12Y 101/01002 (20130101) C12Y 101/99035 (20130101) C12Y 102/02001 (20130101) C12Y 102/03004 (20130101) C12Y 103/03005 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/90 (20130101) H01M 4/92 (20130101) H01M 4/96 (20130101) H01M 4/622 (20130101) H01M 4/663 (20130101) H01M 4/9008 (20130101) H01M 8/16 (20130101) Original (OR) Class H01M 8/1007 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139655 | Perry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| INVENTOR(S) | N. Christopher Perry (Manchester, New Hampshire); Stewart M. Coulter (Bedford, New Hampshire); Thomas A. Doyon (Manchester, New Hampshire) |
| ABSTRACT | A system for powering a device is disclosed. The system includes at least one internal battery located in a device, at least one external battery connected to the device, and a master controller configured to connect either the at least one internal battery or the at least one external battery to a power bus to power the device. |
| FILED | Monday, December 12, 2016 |
| APPL NO | 15/376005 |
| ART UNIT | 2836 — Electrical Circuits and Systems |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/382 (20190101) Electric Digital Data Processing G06F 1/263 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/425 (20130101) H01M 10/482 (20130101) H01M 10/4207 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/38 (20130101) Original (OR) Class H02J 7/0013 (20130101) H02J 7/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139851 | Gong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Songbin Gong (Champaign, Illinois); Ruochen Lu (Champaign, Illinois); John Andrew Krol (Manhattan, Illinois); Liuqing Gao (Champaign, Illinois) |
| ABSTRACT | An apparatus includes parallel delay lines, each exhibiting a delay; a first set of switches for each port of a first set of ports, each of which is to selectively couple a port of the first set of ports to first ends of the delay lines; a second set of switches for each port of a second set of ports, each of which to selectively couple a port of the second set of ports to second ends of the delay lines. A signal source generates a series of clock signals that are sequentially time delayed between the first set of switches and the second set of switches, where an input signal at one of the first or second sets of ports travels back and forth across the first and second sets of delay lines according to activation of the first set and second set of switches until being output. |
| FILED | Tuesday, October 27, 2020 |
| APPL NO | 17/081377 |
| ART UNIT | 2849 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/387 (20130101) Impedance Networks, e.g Resonant Circuits; Resonators H03H 9/74 (20130101) Pulse Technique H03K 5/14 (20130101) H03K 5/135 (20130101) H03K 2005/00078 (20130101) Transmission H04B 1/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11140086 | Halepovic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AT and T INTELLECTUAL PROPERTY I, L.P. (Atlanta, Georgia); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | AT and T INTELLECTUAL PROPERTY I, L.P. (Atlanta, Georgia); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Emir Halepovic (Somerset, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Muhammad Usama Chaudhry (Milpitas, California); Shanyu Zhou (Chicago, Illinois); Balajee Vamanan (Chicago, Illinois); Hulya Seferoglu (Chicago, Illinois) |
| ABSTRACT | In various aspects, a system that comprises detecting a congestion event in a network that transmits a first group of data packets and a second group of data packets, wherein the detecting the congestion event comprises detecting the congestion event has initiated in response to a data packet throughput value of the network having been determined to have decreased below a threshold value; in response to the detecting of the congestion event, determine a transmission rate of the second group of data packets based on a transmission priority of the second group of data packets; determining a data packet dropping rate for the second group of data packets based on the transmission rate of the second group of data packets and a size of the first group of data packets and transmitting the second group of data packets utilizing the transmission rate and the data packet dropping rate. |
| FILED | Thursday, August 15, 2019 |
| APPL NO | 16/542278 |
| ART UNIT | 2472 — Multiplex and VoIP |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/062 (20130101) H04L 43/0829 (20130101) H04L 43/0894 (20130101) H04L 47/24 (20130101) Original (OR) Class H04L 47/6215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11140221 | Amir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| INVENTOR(S) | Yair Amir (Baltimore, Maryland); Amy Babay (Baltimore, Maryland); Thomas Tantillo (Baltimore, Maryland) |
| ABSTRACT | The present invention generally relates to network-attack-resilient intrusion-tolerant Supervisory Control and Data Acquisition (SCADA) systems. Some implementations utilize redundant, proactively-recovery-configured servers at multiple centers communally executing a replication protocol. Some implementations, in addition to control centers, include data centers, which participate in the replication protocol, except that they may not be capable of controlling remote units such as Remote Terminal Units (RTUs). |
| FILED | Wednesday, June 21, 2017 |
| APPL NO | 16/313459 |
| ART UNIT | 2452 — Computer Networks |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/164 (20130101) H04L 63/1425 (20130101) H04L 67/1051 (20130101) Original (OR) Class H04L 67/1095 (20130101) H04L 67/2814 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11140326 | Lunt |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| INVENTOR(S) | Gary A. Lunt (Riverside, California) |
| ABSTRACT | A method of determining geo-reference data for a portion of a measurement area includes providing a monitoring assembly comprising a ground station, providing an imaging assembly comprising an imaging device with a lens operably coupled to an aerial device, hovering the aerial device over a measurement area, capturing at least one image of the measurement area within the imaging device, transmitting the at least one image to the ground station using a data transmitting assembly, and scaling the at least one image to determine the geo-reference data for the portion of the measurement area by calculating a size of a field-of-view (FOV) of the lens based on a distance between the imaging device and the measurement area. |
| FILED | Monday, May 23, 2016 |
| APPL NO | 15/162580 |
| ART UNIT | 2481 — Recording and Compression |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/127 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 3/08 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 3/38 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0263 (20130101) G01S 19/49 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/0063 (20130101) G06K 9/00771 (20130101) Image Data Processing or Generation, in General G06T 7/73 (20170101) G06T 7/246 (20170101) G06T 2207/10032 (20130101) G06T 2207/30212 (20130101) G06T 2207/30236 (20130101) Traffic Control Systems G08G 5/0013 (20130101) G08G 5/0026 (20130101) G08G 5/0069 (20130101) G08G 5/0078 (20130101) G08G 5/0086 (20130101) Pictorial Communication, e.g Television H04N 5/23296 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11140379 | Karvounis |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRX SYSTEMS, INC. (Greenbelt, Maryland) |
| ASSIGNEE(S) | TRX SYSTEMS, INC. (Greenbelt, Maryland) |
| INVENTOR(S) | John George Karvounis (Bowie, Maryland) |
| ABSTRACT | LK-SURF, Robust Kalman Filter, HAR-SLAM, and Landmark Promotion SLAM methods are disclosed. LK-SURF is an image processing technique that combines Lucas-Kanade feature tracking with Speeded-Up Robust Features to perform spatial and temporal tracking using stereo images to produce 3D features can be tracked and identified. The Robust Kalman Filter is an extension of the Kalman Filter algorithm that improves the ability to remove erroneous observations using Principal Component Analysis and the X84 outlier rejection rule. Hierarchical Active Ripple SLAM is a new SLAM architecture that breaks the traditional state space of SLAM into a chain of smaller state spaces, allowing multiple tracked objects, multiple sensors, and multiple updates to occur in linear time with linear storage with respect to the number of tracked objects, landmarks, and estimated object locations. In Landmark Promotion SLAM, only reliable mapped landmarks are promoted through various layers of SLAM to generate larger maps. |
| FILED | Wednesday, September 02, 2020 |
| APPL NO | 17/010727 |
| ART UNIT | 2485 — Recording and Compression |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00201 (20130101) G06K 9/00664 (20130101) G06K 9/3233 (20130101) G06K 9/4671 (20130101) G06K 9/6248 (20130101) G06K 2209/29 (20130101) Image Data Processing or Generation, in General G06T 7/85 (20170101) G06T 7/246 (20170101) G06T 7/277 (20170101) G06T 2200/28 (20130101) G06T 2207/10021 (20130101) G06T 2207/20021 (20130101) G06T 2207/20088 (20130101) Pictorial Communication, e.g Television H04N 5/2224 (20130101) H04N 13/122 (20180501) H04N 13/239 (20180501) Original (OR) Class H04N 13/246 (20180501) H04N 13/282 (20180501) H04N 2013/0092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 11135010 | Pfannenstiel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas); Precision Microwave Inc. (Manhattan, Kansas) |
| ASSIGNEE(S) | Precision Microwave Inc. (Manhattan, Kansas); Kansas State University Research Foundation (Manhattan, Kansas) |
| INVENTOR(S) | Austin Pfannenstiel (Manhattan, Kansas); Hojjatollah Fallahi (Manhattan, Kansas); Punit Prakash (Manhattan, Kansas) |
| ABSTRACT | An electrosurgical device (10) is provided that is operable to deliver microwave energy within a controlled angular expanse to cause targeted tissue ablation. The device (10) comprises a blocking or reflecting material such as cylindrical members (34) that are laterally spaced from the antenna (20) that is operable to emit the microwave energy. The reflecting material creates regions in and/or surrounding the device into which sensors (51), such as thermocouple wires, may be placed to monitor a condition associated with the device or the patient's body. |
| FILED | Friday, May 22, 2020 |
| APPL NO | 16/881780 |
| ART UNIT | 3794 — Medical Instruments, Diagnostic Equipment, and Treatment Devices |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/1815 (20130101) Original (OR) Class A61B 2018/00077 (20130101) A61B 2018/183 (20130101) A61B 2018/00577 (20130101) A61B 2018/00595 (20130101) A61B 2018/00601 (20130101) A61B 2018/00821 (20130101) A61B 2018/1861 (20130101) A61B 2218/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135316 | Achilefu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Samuel Achilefu (St. Louis, Missouri); Nalinikanth Kotagiri (St. Louis, Missouri) |
| ABSTRACT | The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT). In an aspect, the invention encompasses a composition comprising at least two radiation-sensitive molecules. In another aspect, the invention encompasses a composition comprising a radiation-sensitive molecule and a targeting agent. In still another aspect, the invention encompasses a method for administering Cerenkov radiation-induced therapy (CRIT) to a target tissue in a subject. The method comprises administering to the subject an effective amount of a composition B comprising at least one radiation-sensitive molecule and administering to the subject an amount of a Cerenkov radiation (CR)-emitting radionuclide effective to activate the radiation-sensitive molecule, thereby administering CRIT to the target tissue in the subject. |
| FILED | Monday, February 02, 2015 |
| APPL NO | 15/115457 |
| ART UNIT | 1618 — Organic Compounds: Bio-affecting, Body Treating, Drug Delivery, Steroids, Herbicides, Pesticides, Cosmetics, and Drugs |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 41/0038 (20130101) A61K 41/0057 (20130101) A61K 49/0013 (20130101) A61K 49/0021 (20130101) A61K 49/0056 (20130101) Original (OR) Class A61K 51/0474 (20130101) A61K 51/0482 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135573 | Miller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| INVENTOR(S) | Jeffrey T. Miller (West Lafayette, Indiana); Guanghui Zhang (West Lafayette, Indiana) |
| ABSTRACT | An oligomerization catalyst, oligomer products, methods for making and using same. The catalyst can include a supported nickel phosphate compound. The catalyst is stable at oligomerization temperatures of 500° C. or higher and particularly useful for making oligomer products containing C4 to C26 olefins having a boiling point in the range of 170° C. to 360° C. |
| FILED | Friday, March 22, 2019 |
| APPL NO | 16/361411 |
| ART UNIT | 1732 — Metallurgy, Metal Working, Inorganic Chemistry, Catalyst, Electrophotography, Photolithography |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 27/1853 (20130101) Original (OR) Class B01J 35/1019 (20130101) B01J 35/1023 (20130101) B01J 35/1061 (20130101) B01J 2523/847 (20130101) Acyclic or Carbocyclic Compounds C07C 2/24 (20130101) C07C 2527/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135616 | Yeung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Ho Yeung (Bethesda, Maryland); Koushik Viswanathan (Greenwood, Indiana); Walter Dale Compton (West Lafayette, Indiana); Srinivasan Chandrasekar (West Lafayette, Indiana) |
| ABSTRACT | Methods of machining a body to produce a chip wherein the body is formed of a material and in a state such that the material exhibits sinuous flow during a machining operation. The methods include providing a layer located on a surface of the body, and machining the body by causing engagement between a cutting tool and the body in a contact region below an area of the surface having the coating layer thereon and moving the cutting tool relative to the body to produce the chip having the layer thereon. The layer reduces sinuous flow in the material of the body. |
| FILED | Monday, September 16, 2019 |
| APPL NO | 16/571625 |
| ART UNIT | 1766 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 3/002 (20130101) Original (OR) Class B05D 2202/00 (20130101) Turning; Boring B23B 1/00 (20130101) B23B 25/02 (20130101) B23B 2228/10 (20130101) B23B 2228/24 (20130101) B23B 2228/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136251 | Pierre et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Valerie Christine Pierre (Vadnais Heights, Minnesota); Sylvie Lilliane Pailloux (Minneapolis, Minnesota); Sheng-Yin Huang (Minneapolis, Minnesota); Mandapati V. Ramakrishnam Raju (Eagan, Minnesota) |
| ABSTRACT | The present disclosure provides compositions, methods, and devices for sensing, detecting, and/or selectively capturing phosphate from water. An exemplary method includes: contacting a ligand or a rare earth metal complex of a ligand as described herein with an aqueous phosphate-containing medium at a pH of 5 to 12 under conditions sufficient to bind phosphate (e.g., reversibly bind phosphate). In certain embodiments, the method further includes releasing the bound phosphate by contacting the bound phosphate complex with an aqueous medium at a pH of 0 to 4 under conditions sufficient to release the bound phosphate. |
| FILED | Friday, March 23, 2018 |
| APPL NO | 15/934530 |
| ART UNIT | 1777 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/683 (20130101) Original (OR) Class C02F 2101/105 (20130101) C02F 2209/06 (20130101) Acyclic or Carbocyclic Compounds C07C 65/17 (20130101) C07C 211/13 (20130101) C07C 211/65 (20130101) C07C 229/12 (20130101) C07C 259/06 (20130101) Heterocyclic Compounds C07D 213/81 (20130101) C07D 213/89 (20130101) C07D 309/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136453 | Cwiertny et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | David Michael Cwiertny (Iowa City, Iowa); Nosang Vincent Myung (Riverside, California); Katherine Tanya Peter (Iowa City, Iowa); Katherine Elizabeth Greenstein (Iowa City, Iowa); Gene Francis Parkin (Iowa City, Iowa) |
| ABSTRACT | Composites comprising polymeric nanofibers, metal oxide nanoparticles, and optional surface-segregating surfactants and precursor compositions are disclosed. Also disclosed are nonwoven mats formed from the composites and methods of making and using the composites. The composites enable the deployment of nanostructured materials for water treatment within a self-contained membrane with high water fluxes, as well as a number uses. |
| FILED | Friday, May 26, 2017 |
| APPL NO | 16/303807 |
| ART UNIT | 1764 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Separation B01D 39/1623 (20130101) B01D 39/2079 (20130101) B01D 2239/025 (20130101) B01D 2239/0631 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) C08K 3/041 (20170501) C08K 5/19 (20130101) C08K 2003/2227 (20130101) C08K 2003/2268 (20130101) C08K 2003/2272 (20130101) Compositions of Macromolecular Compounds C08L 33/20 (20130101) Original (OR) Class Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/43 (20130101) D04H 1/4242 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136525 | Berman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (Denton, Texas); BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska); INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Indianapolis, Indiana); HUAZHONG AGRICULUTRUAL UNIVERSITY (Wuhan, China PRC) |
| ASSIGNEE(S) | University of North Texas (Denton, Texas); Board of Regents of the University of Nebraska (Lincoln, Nebraska); Indiana University Research and Technology Corp (Indianapolis, Indiana); Huazhong Agricultural University (Wuhan, China PRC) |
| INVENTOR(S) | Diana Berman (Denton, Texas); Kent Dean Chapman (Denton, Texas); Tervor Bradley Romsdahl (Denton, Texas); Edgar Benjamin Cahoon (Lincoln, Nebraska); Robert Earl Minto (Indianapolis, Indiana); Chunyu Zhang (Wuhan, China PRC) |
| ABSTRACT | Various liquid and semisolid lubricant compositions are provided, in particular lubricant compositions containing oil from the seeds of the Brassicaceae Orychophragmus violaceus, preferably those that have been esterified with one or more fatty acids such as palmitoleic acid, oleic acid, linoleic acid, lauric acid, palmitic acid, stearic acid, or a combination thereof. In various aspects, lubricant compositions are provided that include a petroleum or a synthetic base oil and about 40% or less by weight of a liquid lubricant composition containing oil from the seeds of the Brassicaceae Orychophragmus violaceus, preferably those that have been esterified with one or more fatty acids. In various aspects, semisolid lubricant composition are provided containing an emulsion of (i) a thickener and (ii) an oil from the seeds of the Brassicaceae Orychophragmus violaceus, preferably those that have been esterified with one or more fatty acids. |
| FILED | Friday, December 14, 2018 |
| APPL NO | 16/772110 |
| ART UNIT | 1771 — Chemical Apparatus, Separation and Purification, Liquid and Gas Contact Apparatus |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 105/40 (20130101) C10M 109/02 (20130101) C10M 117/04 (20130101) C10M 119/20 (20130101) C10M 169/00 (20130101) Original (OR) Class C10M 2207/401 (20130101) C10M 2207/1265 (20130101) C10M 2207/1285 (20130101) C10M 2207/2835 (20130101) C10M 2209/126 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2030/02 (20130101) C10N 2030/04 (20130101) C10N 2030/06 (20130101) C10N 2030/10 (20130101) C10N 2030/12 (20130101) C10N 2030/14 (20130101) C10N 2050/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136553 | Yarmush et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Martin Yarmush (Newton, Massachusetts); Basak E. Uygun (Cambridge, Massachusetts); Korkut Uygun (Cambridge, Massachusetts); Maria-Louisa Izamis (Boston, Massachusetts); Alejandro Soto-Gutierrez (Boston, Massachusetts); Herman Tolboom (Zurich, Switzerland); Hiroshi Yagi (Brookline, Massachusetts); Carley Shulman (Sudbury, Massachusetts); Jack Milwid (Denver, Colorado) |
| ABSTRACT | One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ. |
| FILED | Tuesday, April 07, 2015 |
| APPL NO | 14/645527 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/021 (20130101) A01N 1/0247 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/407 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/067 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136559 | Maeda et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| INVENTOR(S) | Hiroshi A. Maeda (Madison, Wisconsin); Craig Albert Schenck (Madison, Wisconsin) |
| ABSTRACT | The invention generally relates to engineered prephenate dehydrogenases and arogenate dehydrogenases and methods of using the same. More specifically, the invention relates in part to compositions including engineered prephenate dehydrogenases (PDH) polypeptides and engineered arogenate dehydrogenase (ADH) polypeptides with altered substrate preferences and tyrosine sensitivities and methods of using the same. |
| FILED | Monday, January 29, 2018 |
| APPL NO | 15/882636 |
| ART UNIT | 1663 — Plants |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/001 (20130101) Original (OR) Class C12N 15/8251 (20130101) Enzymes C12Y 103/01012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136573 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | David Baker (Seattle, Washington); David Younger (Seattle, Washington); Eric Klavins (Seattle, Washington) |
| ABSTRACT | The present invention relates to methods and compositions for the high throughput screening of protein-protein interactions in yeast liquid culture. Protein fusions non-native to yeast may be expressed to replace endogenous sexual agglutination proteins and mediate library-by-library interrogation of protein interactions. The methods and compositions of the invention can be utilized for the characterization of protein interaction networks in high throughput for both binding affinity and specificity, which is crucial for understanding cellular functions, screening therapeutic candidates, and evaluating engineered protein networks. |
| FILED | Friday, November 06, 2020 |
| APPL NO | 17/091847 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1055 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136574 | Jewett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Michael Christopher Jewett (Evanston, Illinois); Brian R. Fritz (Chicago, Illinois) |
| ABSTRACT | Disclosed are methods, components, compositions, and kits for preparing and identifying engineered E. coli ribosomes. The E. coli ribosomes may be prepared and identified under a set of defined conditions, such as in the presences of antibiotics, in order to obtain an engineered ribosome that is resistant to the antibiotic. |
| FILED | Monday, October 07, 2019 |
| APPL NO | 16/595438 |
| ART UNIT | 1639 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1041 (20130101) C12N 15/1058 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 30/04 (20130101) C40B 40/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136595 | Salaita et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | Emory University (Atlanta, Georgia) |
| INVENTOR(S) | Khalid Salaita (Decatur, Georgia); Jessica Petree (Lawrenceville, Georgia); Kevin Yehl (Quincy, Massachusetts) |
| ABSTRACT | This disclosure relates to compositions comprising particles conjugated to one or more catalytically cleaving nucleic acids and optionally an RNA ligating enzyme. In certain embodiments, particles reported herein are used for splicing nucleic acid sequences. |
| FILED | Monday, November 05, 2018 |
| APPL NO | 16/180786 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/93 (20130101) C12N 15/52 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/902 (20130101) Original (OR) Class C12N 2310/127 (20130101) C12N 2320/33 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6823 (20130101) Enzymes C12Y 301/00 (20130101) C12Y 605/01004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136597 | Saltzman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yale University (New Haven, Connecticut); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | Yale University (New Haven, Connecticut); Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | W. Mark Saltzman (New Haven, Connecticut); Peter Glazer (Guilford, Connecticut); Raman Bahal (Hamden, Connecticut); Nicole Ali McNeer (Westport, Connecticut); Danith H. Ly (Pittsburgh, Pennsylvania); Elias Quijano (New Haven, Connecticut) |
| ABSTRACT | Compositions and methods for enhancing targeted gene editing and methods of use thereof are disclosed. In the most preferred embodiments, gene editing is carried out utilizing a gene editing composition such as triplex-forming oligonucleotides, CRISPR, zinc finger nucleases, TALENS, or others, in combination with a gene modification potentiating agent such as stem cell factor (SCF), a CHK1 or ATR inhibitor, or a combination thereof. A particular preferred gene editing composition is triplex-forming peptide nucleic acids (PNAs) substituted at the γ position for increased DNA binding affinity. Nanoparticle compositions for intracellular delivery of the gene editing composition are also provided and particular advantageous for use with in vivo applications. |
| FILED | Thursday, February 16, 2017 |
| APPL NO | 15/434978 |
| ART UNIT | 1635 — Molecular Biology, Bioinformatics, Nucleic Acids, Recombinant DNA and RNA, Gene Regulation, Nucleic Acid Amplification, Animals and Plants, Combinatorial/ Computational Chemistry |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1647 (20130101) A61K 48/005 (20130101) Peptides C07K 14/003 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/15 (20130101) C12N 2310/152 (20130101) C12N 2310/318 (20130101) C12N 2310/334 (20130101) C12N 2310/351 (20130101) C12N 2310/3181 (20130101) C12N 2310/3519 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136632 | Lavrentovich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kent State University (Kent, Ohio) |
| ASSIGNEE(S) | KENT STATE UNIVERSITY (Kent, Ohio) |
| INVENTOR(S) | Oleg D. Lavrentovich (Kent, Ohio); Chenhui Peng (Kent, Ohio); Taras Turiv (Kent, Ohio); Yubing Guo (Kent, Ohio); Qi-Huo Wei (Hudson, Ohio) |
| ABSTRACT | A method for controlling self-propelled particles includes providing the particles to a liquid crystalline medium having predesigned local ordering. The method may control at least one of: a local concentration, trajectory, and net flow of self-propelled particles. |
| FILED | Friday, August 10, 2018 |
| APPL NO | 16/100394 |
| ART UNIT | 1653 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/52 (20130101) C09K 19/56 (20130101) C09K 19/544 (20130101) C09K 19/601 (20130101) C09K 2019/0448 (20130101) C09K 2019/2078 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 1/08 (20130101) C12R 1/09 (20130101) C12R 1/10 (20130101) C12R 1/11 (20130101) C12R 1/12 (20130101) C12R 1/075 (20130101) C12R 1/085 (20130101) C12R 1/125 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136666 | Nasseri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| INVENTOR(S) | Mohsen Nasseri (Lexington, Kentucky); Armin Ansary (Lexington, Kentucky); Mathias J. Boland (Lexington, Kentucky); Douglas R. Strachan (Lexington, Kentucky) |
| ABSTRACT | A nanoscale conductor/semiconductor/insulator device includes a substrate with a lattice and a plurality of nanotubes in crystallographic alignment with the lattice at an interface between the plurality of nanotubes and the substrate. Another such device includes a substrate, meandering tracks in the substrate and a plurality of nanotubes adhering to cut-atomic-step edges of the meandering tracks. Methods of making the nanoscale conductor/semiconductor/insulator devices are also disclosed. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 16/557777 |
| ART UNIT | 1783 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/26 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) Original (OR) Class C23C 16/0227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136688 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Li Yang (Crestwood, Kentucky); Yan Wu (Louisville, Kentucky); Christopher O'Neil (Louisville, Kentucky); Austin Lassell (Georgetown, Kentucky); Hengfeng Gu (South Jordan, Utah) |
| ABSTRACT | Systems and processes for treating surfaces of metal components are provided. The systems can include a container for containing a metal workpiece having a surface with a complex external geometry and for containing a solution that has electrolytes at a flow rate that varies according to a local shape of the surface to thereby treat the surface of the metal workpiece; optionally one or more electrodes for creating an electrical field; and optionally a temperature control device configured to provide a predetermined temperature or range of temperatures. The processes can include providing a metal workpiece having a surface with a complex external geometry; and contacting the workpiece in the presence of a predetermined electrical field at a predetermined temperature with a solution containing electrolytes at a flow rate that varies according to a local shape of the surface to thereby treat the surface of the metal workpiece. |
| FILED | Thursday, August 08, 2019 |
| APPL NO | 16/536164 |
| ART UNIT | 1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/16 (20130101) Original (OR) Class C25F 3/26 (20130101) C25F 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136734 | Thota et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of The University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Manoj Thota (Ann Arbor, Michigan); Suyi Li (Clemson, South Carolina); Kon-Well Wang (Ann Arbor, Michigan) |
| ABSTRACT | A sound barrier system for use in mitigating noise having an origami sheet or origami-inspired mechanism that can use folding to change configuration and lattice topology; and a plurality of cylindrical inclusions disposed on top of the origami sheet. The plurality of cylindrical inclusions being periodically arranged such that folding kinematics of the origami sheet induces reconfiguration of the periodicity of the plurality of cylindrical inclusions and associated wave blocking of the noise. |
| FILED | Wednesday, September 19, 2018 |
| APPL NO | 16/135538 |
| ART UNIT | 2837 — Electrical Circuits and Systems |
| CURRENT CPC | Additional Work, Such as Equipping Roads or the Construction of Platforms, Helicopter Landing Stages, Signs, Snow Fences, or the Like E01F 8/0011 (20130101) E01F 8/0023 (20130101) Original (OR) Class E01F 8/0041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137298 | Pan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Tingrui Pan (Woodland, California); Ruya Li (Beijing, China PRC); Benjamin Arthur Bazor (Davis, California) |
| ABSTRACT | An all-fabric iontronic supercapacitive pressure sensing device utilizing a novel iontronic nanofabric as the sensing element is disclosed. The sensing device can be applied in several various wearable health and biomedical applications on complex body topologies. As an alternative to conventional flexible sensors, the all-fabric iontronic pressure sensor provides an ultrahigh device sensitivity with a single Pascale resolution. The device also allows rapid mechanical responses (in the milliseconds range) for high-frequency biomechanical signals, e.g., blood pressure pulses and body movements. The fabrication process for the device is low-cost highly compatible with existing industrial manufacturing processes. |
| FILED | Monday, November 18, 2019 |
| APPL NO | 16/687484 |
| ART UNIT | 2855 — Printing/Measuring and Testing |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 1/002 (20130101) A41D 13/1281 (20130101) A41D 19/0027 (20130101) A41D 25/00 (20130101) A41D 27/205 (20130101) Characteristic Features of Footwear; Parts of Footwear A43B 3/0005 (20130101) A43B 7/147 (20130101) A43B 13/02 (20130101) A43B 23/0205 (20130101) Diagnosis; Surgery; Identification A61B 5/447 (20130101) A61B 5/6803 (20130101) A61B 5/6804 (20130101) A61B 5/6806 (20130101) A61B 2503/10 (20130101) A61B 2505/05 (20130101) A61B 2562/0247 (20130101) A61B 2562/0285 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/022 (20130101) B32B 5/024 (20130101) B32B 2307/202 (20130101) B32B 2437/02 (20130101) Woven Fabrics; Methods of Weaving; Looms D03D 1/0088 (20130101) D03D 15/00 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2401/16 (20130101) D10B 2501/041 (20130101) D10B 2501/043 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/146 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137310 | White et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Thomas P. White (Lubbock, Texas); Satish Shetty (Fayetteville, Arkansas); Morgan E. Ware (Fayetteville, Arkansas); H. Alan Mantooth (Fayetteville, Arkansas); Gregory J. Salamo (Fayetteville, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas P. White (Lubbock, Texas); Satish Shetty (Fayetteville, Arkansas); Morgan E. Ware (Fayetteville, Arkansas); H. Alan Mantooth (Fayetteville, Arkansas); Gregory J. Salamo (Fayetteville, Arkansas) |
| ABSTRACT | GaN/Al0.20Ga0.80N/GaN heterostructures Micro-Hall effect sensors providing simultaneous current and temperature detection over at least a best performance temperature range of −183° C. and 252° C. |
| FILED | Tuesday, October 16, 2018 |
| APPL NO | 16/161260 |
| ART UNIT | 2867 — Printing/Measuring and Testing |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/36 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 19/0092 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 15/202 (20130101) G01R 33/07 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137394 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Pengyu Chen (Ann Arbor, Michigan); Katsuo Kurabayashi (Ann Arbor, Michigan); Timothy T. Cornell (Ann Arbor, Michigan); Thomas P. Shanley (Ann Arbor, Michigan); Meng Ting Chung (Ann Arbor, Michigan); Yujing Song (Ann Arbor, Michigan); Walker M. McHugh (Dexter, Michigan) |
| ABSTRACT | Provided herein are systems and methods for assays. In particular, provided herein are systems and methods for performing high throughput immunoassays. Embodiments of the present disclosure provide multiplex capable LSPR immunoassays that meet a need for rapid (e.g., near real time), accurate immunoassays (e.g. for use in beside diagnostics). The LSPR assays are as accurate as existing ELISA assays but provide the advantage of increased speed and multiplex capability. In addition, the LSPR immunoassays are able to analyze small volumes of complex patient samples (e.g., serum). |
| FILED | Tuesday, February 16, 2016 |
| APPL NO | 15/551164 |
| ART UNIT | 1641 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) B01L 2300/123 (20130101) B01L 2300/161 (20130101) B01L 2300/0636 (20130101) B01L 2300/0645 (20130101) B01L 2300/0816 (20130101) B01L 2300/0861 (20130101) B01L 2300/0877 (20130101) B01L 2400/043 (20130101) B01L 2400/0406 (20130101) B01L 2400/0415 (20130101) B01L 2400/0442 (20130101) B01L 2400/0457 (20130101) B01L 2400/0487 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54346 (20130101) G01N 33/54373 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137719 | Chakravarthula et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| INVENTOR(S) | Praneeth Kumar Chakravarthula (Carrboro, North Carolina); Felix Heide (Palo Alto, California) |
| ABSTRACT | A method for digital holography includes modeling a hologram using a forward propagation model that models propagation of a light field from a hologram plane to an image plane. The method further includes computing the hologram as a solution to an optimization problem that is based on the model. The method further includes configuring at least one spatial light modulator using the hologram. The method further includes illuminating the spatial light modulator using a light source to create a target image. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 16/710845 |
| ART UNIT | 2872 — Optics |
| CURRENT CPC | Holographic Processes or Apparatus G03H 1/0808 (20130101) G03H 1/0866 (20130101) Original (OR) Class G03H 2226/02 (20130101) G03H 2240/61 (20130101) G03H 2240/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139853 | Eletreby et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Rashad Eletreby (Pittsburgh, Pennsylvania); Swarun Kumar (Pittsburgh, Pennsylvania); Osman Yagan (Pittsburgh, Pennsylvania); Diana Zhang (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described herein is a system that overcomes challenges pertaining to density and range of urban LP-WANs despite the limited capabilities of base station and client hardware. The invention proposes a novel technique that aims to disentangle and decode large numbers of interfering transmissions at a simple, single-antenna LP-WAN base station by exploiting the hardware imperfections of low-cost LP-WAN clients to its advantage Second, the present invention exploits the correlation of sensed data collected by LP-WAN nodes to collaboratively reach a far-away base station, even if individual clients are beyond its range. |
| FILED | Wednesday, July 03, 2019 |
| APPL NO | 17/053406 |
| ART UNIT | 2632 — Digital Communications |
| CURRENT CPC | Transmission H04B 1/69 (20130101) Original (OR) Class H04B 2001/6912 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0202 (20130101) H04L 27/103 (20130101) H04L 27/144 (20130101) H04L 27/265 (20130101) Wireless Communication Networks H04W 52/0209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139899 | Oelze et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Michael L. Oelze (Champaign, Illinois); Thomas Riedl (Urbana, Illinois); Andrew Singer (Champaign, Illinois) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, receiving, by a receiver through a medium from a transmitter, signals over an acoustic channel, where the receiving over the acoustic channel utilizes a high center frequency and provides for a high data rate, and where the medium is a fluid or a semi-solid medium. The device can receive power from the transmitter over the acoustic channel. Other embodiments are disclosed. |
| FILED | Thursday, May 26, 2016 |
| APPL NO | 15/576083 |
| ART UNIT | 3645 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0002 (20130101) A61B 5/0028 (20130101) A61B 5/0031 (20130101) Transmission H04B 11/00 (20130101) Original (OR) Class H04B 13/02 (20130101) H04B 13/005 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/34 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 367/904 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11140086 | Halepovic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AT and T INTELLECTUAL PROPERTY I, L.P. (Atlanta, Georgia); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | AT and T INTELLECTUAL PROPERTY I, L.P. (Atlanta, Georgia); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Emir Halepovic (Somerset, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Muhammad Usama Chaudhry (Milpitas, California); Shanyu Zhou (Chicago, Illinois); Balajee Vamanan (Chicago, Illinois); Hulya Seferoglu (Chicago, Illinois) |
| ABSTRACT | In various aspects, a system that comprises detecting a congestion event in a network that transmits a first group of data packets and a second group of data packets, wherein the detecting the congestion event comprises detecting the congestion event has initiated in response to a data packet throughput value of the network having been determined to have decreased below a threshold value; in response to the detecting of the congestion event, determine a transmission rate of the second group of data packets based on a transmission priority of the second group of data packets; determining a data packet dropping rate for the second group of data packets based on the transmission rate of the second group of data packets and a size of the first group of data packets and transmitting the second group of data packets utilizing the transmission rate and the data packet dropping rate. |
| FILED | Thursday, August 15, 2019 |
| APPL NO | 16/542278 |
| ART UNIT | 2472 — Multiplex and VoIP |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/062 (20130101) H04L 43/0829 (20130101) H04L 43/0894 (20130101) H04L 47/24 (20130101) Original (OR) Class H04L 47/6215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11140595 | Jamieson |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Kyle Jamieson (Princeton, New Jersey) |
| ABSTRACT | Disclosed is a design and implementation of a Wi-Fi based network (e.g., roadside hotspot network designed to operate at vehicular speeds and picocell, meter-sized, cells). The disclosed access points (APs) make delivery decisions to the vehicular clients they serve at millisecond-level granularities, exploiting path diversity in roadside networks. In order to accomplish this, buffer management algorithms are employed that allow participating APs to manage each other's queues, rapidly quenching each other's transmissions and flushing each other's queues. An example embodiment of the disclosed approach employs an eight-AP network alongside a nearby road, and was evaluated with mobile clients moving at up to 25 mph. Depending on mobility speed, the disclosed approach achieves a 2.4-4.7 times TCP throughput improvement over a baseline fast handover protocol that captures the state of the art in Wi-Fi roaming, the IEEE 802.11k and 802.11r standards. |
| FILED | Friday, March 02, 2018 |
| APPL NO | 16/488693 |
| ART UNIT | 2644 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Wireless Communication Networks H04W 36/04 (20130101) H04W 36/08 (20130101) Original (OR) Class H04W 84/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 11135582 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178824 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 2400/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11135669 | Stabach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cree Fayetteville, Inc. (Fayetteville, Arkansas) |
| ASSIGNEE(S) | CREE, INC. (Durham, North Carolina) |
| INVENTOR(S) | Jennifer Stabach (Rogers, Arkansas); Brice McPherson (Fayetteville, Arkansas); Chad B. O'Neal (Springdale, Arkansas) |
| ABSTRACT | A process for manufacturing an electronic component having attaches includes providing a first component having a first attach, forming trenches on a portion of the first attach with a laser to form a solder stop, and providing a second component comprising a second attach. The process further includes providing solder between the first attach and the second attach to form a connection between the first component and the second component, where the trenches contain the solder to a usable area. A device produced by the process is disclosed as well. |
| FILED | Monday, September 17, 2018 |
| APPL NO | 16/133411 |
| ART UNIT | 2848 — Electrical Circuits and Systems |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0016 (20130101) B23K 1/20 (20130101) Original (OR) Class B23K 26/361 (20151001) B23K 26/362 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/13 (20130101) H01L 23/3735 (20130101) H01L 23/49894 (20130101) H01L 2224/32225 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0263 (20130101) H05K 3/027 (20130101) H05K 3/243 (20130101) H05K 3/341 (20130101) H05K 2201/09363 (20130101) H05K 2203/0315 (20130101) H05K 2203/1173 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136601 | Beckham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| INVENTOR(S) | Gregg Tyler Beckham (Golden, Colorado); Christopher W. Johnson (Denver, Colorado); Sandra Fabienne Notonier (Golden, Colorado) |
| ABSTRACT | The present disclosure relates to a genetically modified microbial cell that includes a genetic modification resulting in the expression of a vanillate demethylase, where the microbial cell is capable of metabolizing at least one S-lignin decomposition molecule including at least one of syringate and/or 3-O-methyl gallate, and the genetically modified microbial cell is capable of producing gallate. In some embodiments of the present disclosure, the vanillate demethylase may include VanAB. |
| FILED | Friday, August 02, 2019 |
| APPL NO | 16/530539 |
| ART UNIT | 1656 — Fermentation, Microbiology, Isolated and Recombinant Proteins/Enzymes |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 15/78 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/002 (20130101) C12P 7/22 (20130101) Original (OR) Class C12P 7/42 (20130101) C12P 2203/00 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 1/39 (20130101) C12R 1/40 (20130101) Enzymes C12Y 114/13082 (20130101) C12Y 301/01057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136666 | Nasseri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| INVENTOR(S) | Mohsen Nasseri (Lexington, Kentucky); Armin Ansary (Lexington, Kentucky); Mathias J. Boland (Lexington, Kentucky); Douglas R. Strachan (Lexington, Kentucky) |
| ABSTRACT | A nanoscale conductor/semiconductor/insulator device includes a substrate with a lattice and a plurality of nanotubes in crystallographic alignment with the lattice at an interface between the plurality of nanotubes and the substrate. Another such device includes a substrate, meandering tracks in the substrate and a plurality of nanotubes adhering to cut-atomic-step edges of the meandering tracks. Methods of making the nanoscale conductor/semiconductor/insulator devices are also disclosed. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 16/557777 |
| ART UNIT | 1783 — Miscellaneous Articles, Stock Material |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/26 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) Original (OR) Class C23C 16/0227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136679 | Choi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Kyoung-Shin Choi (Fitchburg, Wisconsin); Hyun Gil Cha (Madison, Wisconsin) |
| ABSTRACT | Photoelectrochemical cells for the oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid and/or 2,5-diformylfuran are provided. Also provided are methods of using the cells to carry out the electrochemical and photoelectrochemical oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid and/or 2,5-diformylfuran. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 16/844437 |
| ART UNIT | 1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/21 (20210101) C25B 3/23 (20210101) Original (OR) Class C25B 9/00 (20130101) C25B 9/17 (20210101) C25B 11/043 (20210101) C25B 11/051 (20210101) C25B 11/073 (20210101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2004 (20130101) H01G 9/2027 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/542 (20130101) Y02E 60/36 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/133 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136686 | Tripathy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BATTELLE ENERGY ALLIANCE, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | BATTELLE ENERGY ALLIANCE, LLC. (Idaho Fall, Idaho) |
| INVENTOR(S) | Prabhat K. Tripathy (Ammon, Idaho); Guy L. Fredrickson (Idaho Falls, Idaho); Eric J. Dufek (Ammon, Idaho); Laura A. Wurth (Ferndale, Washington); J. Stephen Herring (Idaho Falls, Idaho) |
| ABSTRACT | Systems and methods for coating a metallic component are provided. In one embodiment, a metallic coating may be disposed in a plating bath comprising AlBr3. The metallic coating may be coupled with, or configured as, a working electrode. A counter electrode formed of aluminum may be disposed within the plating bath. An electric current may be applied between the two electrodes resulting in the electrodeposition of aluminum on the metallic component. In one particular embodiment, the plating bath may include LiBr, KBr and CsBr, with AlBr3 being present in an amount of approximately 80 percent or greater by weight. Various types of metals may be coated with aluminum using embodiments of the present disclosure. Additionally, the methods and systems described herein are amenable to coating of complex geometries. |
| FILED | Friday, July 15, 2016 |
| APPL NO | 15/744022 |
| ART UNIT | 1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 3/44 (20130101) C25D 3/66 (20130101) Original (OR) Class C25D 5/50 (20130101) C25D 17/04 (20130101) C25D 17/10 (20130101) C25D 21/02 (20130101) C25D 21/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137112 | Kuczek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Andrzej Ernest Kuczek (Bristol, Connecticut); Wenping Zhao (Glastonbury, Connecticut); Paul F. Croteau (Columbia, Connecticut); Ellen Y. Sun (South Windsor, Connecticut) |
| ABSTRACT | A pressure vessel assembly includes a vessel including a wall defining a chamber and a circumferentially continuous lip projecting into the chamber from the wall. The lip defines a through-bore in fluid communication with the chamber. A nozzle assembly including a tube and a flange projecting radially outward from the tube. The tube includes a first portion projecting from the flange and through the through-bore and an opposite second portion projecting outward from the flange. The flange is in contact with the wall and the first portion includes an outer surface having a contour configured to produce sealing friction between the lip and the outer surface. |
| FILED | Wednesday, November 25, 2015 |
| APPL NO | 15/779161 |
| ART UNIT | 3733 — Sheet Container Making, Package Making, Receptacles, Shoes, Apparel, and Tool Driving or Impacting |
| CURRENT CPC | Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 1/06 (20130101) Original (OR) Class F17C 1/16 (20130101) F17C 11/007 (20130101) F17C 13/00 (20130101) F17C 13/002 (20130101) F17C 2201/0152 (20130101) F17C 2201/0171 (20130101) F17C 2203/066 (20130101) F17C 2203/0604 (20130101) F17C 2203/0629 (20130101) F17C 2203/0631 (20130101) F17C 2203/0663 (20130101) F17C 2203/0673 (20130101) F17C 2205/013 (20130101) F17C 2205/0142 (20130101) F17C 2205/0305 (20130101) F17C 2209/2118 (20130101) F17C 2209/2127 (20130101) F17C 2221/012 (20130101) F17C 2221/031 (20130101) F17C 2221/033 (20130101) F17C 2221/035 (20130101) F17C 2260/012 (20130101) F17C 2260/013 (20130101) F17C 2270/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137169 | Buscheck et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Thomas A. Buscheck (Pleasanton, California); Ravindra Shrikrishna Upadhye (Pleasanton, California) |
| ABSTRACT | The present disclosure relates to a method for storing excess energy from at least one energy producing source, as thermal energy, using an existing geologic formation. First and second storage zones formed in a geologic region may be used to store high temperature and medium high temperature brine. When excess energy is available from the energy producing source, a quantity of the medium high temperature brine is withdrawn and heated using the energy supplied by the energy source to form a first new quantity of high temperature brine, which is then injected back into the first storage zone. This forces a quantity of medium high temperature brine present in the first storage zone into the second storage zone, to maintain a desired quantity of high temperature brine in the first storage zone and a desired quantity of medium high temperature brine in the second storage zone. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 16/711288 |
| ART UNIT | 3746 — Thermal & Combustion Technology, Motive & Fluid Power Systems |
| CURRENT CPC | Steam Engine Plants; Steam Accumulators; Engine Plants Not Otherwise Provided For; Engines Using Special Working Fluids or Cycles F01K 27/00 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/04 (20130101) F03G 7/06 (20130101) Geothermal Collectors; Geothermal Systems F24T 10/20 (20180501) Original (OR) Class Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/0052 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 6/34 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 20/16 (20130101) Y02E 60/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137458 | Mehta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Hardeep S. Mehta (Richland, Washington); Jesse A. Sears, Jr. (Kennewick, Washington); Eric D. Walter (West Richland, Washington); Nancy M. Washton (Richland, Washington); Karl T. Mueller (Richland, Washington); Ying Chen (Richland, Washington) |
| ABSTRACT | A rotor housing assembly for NMR spectroscopy. An elongate rotor has a distal drive end, a proximal end and an internal sample space positioned along its length between the drive and proximal ends. The rotor is driveable about a rotation axis by a drive gas flow. A rotor housing has an interior space in which the rotor is at least partially received. At least one first heated gas flow inlet is positioned opposite the internal sample space, through which a first heated gas flow is controllably flowable into the interior space to heat it and the rotor. At least a pair of spaced apart second heated gas flow outlets are axially spaced from the first heated gas flow inlet to controllably convey a second heated gas flow to heat distal and proximal areas of the sample space to minimize a temperature gradient extending axially within the sample space. |
| FILED | Friday, May 29, 2020 |
| APPL NO | 16/888374 |
| ART UNIT | 2852 — Printing/Measuring and Testing |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/088 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/31 (20130101) Original (OR) Class G01R 33/46 (20130101) G01R 33/307 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137516 | Whittaker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | William Lawrence Whittaker (Pittsburgh, Pennsylvania); Siri Katrina Maley (Pittsburgh, Pennsylvania); Heather Louise Jones (Pittsburgh, Pennsylvania); Oleg Borisovich Sapunkov (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein are a method, apparatus, and software for passive, non-destructive assay of holdup deposits in nuclear piping by in-pipe apparatus. A detector deployed within a pipe is collimated to observe radiation impinging radially inward from decay of deposits that lie on the pipe wall. A radiation detector is centered in the pipe and collimated by a pair of coaxial shielding discs disposed equidistant from the detector. This arrangement causes radiation from a truncated cylinder of pipe deposit within a field of regard to impinge on the detector, while precluding radiation emanating from pipe walls beyond the field of regard from reaching the detector. Hence, observations are unique to a known cylindrical length of pipe. The detector assembly is translated through pipes by an autonomous mobile robotic apparatus. Computer software controls the robotic apparatus, logs data, and post-processes to assay deposits. |
| FILED | Friday, September 21, 2018 |
| APPL NO | 16/649305 |
| ART UNIT | 2884 — Optics |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/202 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 5/0091 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137591 | Panas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Goverment of the United States, as represented by the Secretary of the Air Force (Washington, District of Columbia) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Robert Matthew Panas (Dublin, California); Harris J. Hall (Yellow Springs, Ohio); Lavern A. Starman (Dayton, Ohio) |
| ABSTRACT | The present disclosure relates to an imaging system which may make use of an electronic controller, a digital micromirror array, an aperture control system and a detector to image a desired scene. The digital micromirror array has a plurality of micromirror elements responsive to control signals generated by the electronic controller for electronically aiming the micromirror elements in a desired direction to image the desired area, and for receiving and reflecting light emanating from the desired area. The aperture control system receives light reflected from the digital micromirror array and passes a predetermined subportion of the received light therethrough. The detector is responsive to the predetermined subportion of light. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 16/817213 |
| ART UNIT | 2637 — Optical Communications |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 26/0833 (20130101) Original (OR) Class Transmission H04B 10/11 (20130101) H04B 10/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11137809 | Rao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | Karthik Rao (Austin, Texas); Wei Huang (Frisco, Texas); Xudong An (Irving, Texas); Manish Arora (Dublin, California); Joseph L. Greathouse (Austin, Texas) |
| ABSTRACT | A plurality of thermal electric cooler (TEC) elements are formed in a TEC grid structure. Control logic dynamically varies a supply current supplied to each TEC element (or group of TEC elements) in the TEC grid based on changes in power density respectively associated with areas cooled by each of the TEC elements or group of TEC elements. |
| FILED | Thursday, December 20, 2018 |
| APPL NO | 16/228036 |
| ART UNIT | 2186 — Computer Architecture and I/O |
| CURRENT CPC | Electric Digital Data Processing G06F 1/26 (20130101) G06F 1/206 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11138063 | Diao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | OHIO STATE INNOVATION FOUNDATION (Columbus, Ohio) |
| INVENTOR(S) | Xiaoxu Diao (Columbus, Ohio); Carol Smidts (Columbus, Ohio); Chetan Mutha (Arlington, Virginia) |
| ABSTRACT | Systems and methods are provided for generating faults and analyzing fault propagation and its effects. Starting from the ontologies of components, functions, flows, and faults, systems and methods are provided that describe, generate and track faults in a computer system across multiple domains throughout design and/or development. In order to construct the system and fault models, a series of concepts is introduced in the form of ontologies and their dependencies. An investigation is performed into the faults, including their type, cause, life-cycle aspects, and effect. Principles and rules are created to generate various faults based on system configurations. After the modeling process, a simulation engine is described to execute actions and simulate the process of fault generation and propagation. As a result, fault paths that impact components and functions can be obtained. |
| FILED | Tuesday, July 07, 2020 |
| APPL NO | 16/922488 |
| ART UNIT | 2114 — Computer Error Control, Reliability, & Control Systems |
| CURRENT CPC | Electric Digital Data Processing G06F 11/0721 (20130101) G06F 11/0793 (20130101) Original (OR) Class G06F 30/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11138902 | White et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Gregory K. White (Livermore, California); William H. Dunlop (Livermore, California); TR Koncher (Brentwood, California); Steve Kreek (Livermore, California) |
| ABSTRACT | An incident simulation system supports an incident exercise in a virtual environment. The incident simulation system accesses a simulation plan defining an incident within a theater of operation. The incident simulation system simulates the incident exercise by displaying, to a participant in the incident exercise, images representing what the participant would see within the theater of operation as the participant moves within the theater of operation. The incident simulation system further simulates the incident by generating incident data indicating effects of the incident at target locations and at target times as the participant moves within the theater of operation. The incident simulation system further simulates the incident by displaying to the participant images representing the user experience that a detector would provide based on the generated incident data. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 16/834907 |
| ART UNIT | 3715 — Amusement and Education Devices |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/02 (20130101) G09B 19/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139403 | Lin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SUNPOWER CORPORATION (San Jose, California) |
| ASSIGNEE(S) | SunPower Corporation (San Jose, California) |
| INVENTOR(S) | Yafu Lin (San Jose, California); Benjamin Francois (San Jose, California) |
| ABSTRACT | A high efficiency configuration for a solar cell module comprises solar cells arranged in an overlapping shingled manner and conductively bonded to each other in their overlapping regions to form super cells, which may be arranged to efficiently use the area of the solar module. |
| FILED | Wednesday, August 14, 2019 |
| APPL NO | 16/540372 |
| ART UNIT | 2812 — Semiconductors/Memory |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/028 (20130101) H01L 31/042 (20130101) H01L 31/188 (20130101) H01L 31/0201 (20130101) Original (OR) Class H01L 31/0504 (20130101) H01L 31/1804 (20130101) H01L 31/022433 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139840 | Deng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Z. Daniel Deng (Richland, Washington); Jun Lu (Richland, Washington); Huidong Li (Richland, Washington); Chuan Tian (Richland, Washington); Mitchell J. Myjak (Richland, Washington); Brian J. Bellgraph (Richland, Washington); Sam Cartmell (Richland, Washington); Jie Xiao (Richland, Washington) |
| ABSTRACT | Methods for attaching a radio frequency (RF) transmitter to an animal are provided. The methods can include providing an RF transmitter and providing an injection device having a needle of gauge of 9 or smaller; providing the RF transmitter into the injection device; and providing the RF transmitter through the 9 gauge or smaller needle and into the animal. |
| FILED | Friday, November 16, 2018 |
| APPL NO | 16/193968 |
| ART UNIT | 2648 — Telecommunications: Analog Radio Telephone; Satellite and Power Control; Transceivers, Measuring and Testing; Bluetooth; Receivers and Transmitters; Equipment Details |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 11/006 (20130101) A01K 11/008 (20130101) A01K 61/90 (20170101) A01K 99/00 (20130101) Diagnosis; Surgery; Identification A61B 5/1112 (20130101) A61B 5/6861 (20130101) A61B 2503/40 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 1/02 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/0723 (20130101) G06K 19/07762 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/5835 (20130101) H01M 2220/30 (20130101) Transmission H04B 1/034 (20130101) Original (OR) Class H04B 2001/3894 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139963 | Bush |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | General Electric Company (Schenectady, New York) |
| INVENTOR(S) | Stephen Francis Bush (Latham, New York) |
| ABSTRACT | A communication system is provided that includes a first quantum key distribution device configured to be coupled to a second quantum key distribution device over a quantum channel that communicates a quantum state via the quantum channel, a classical device coupled to the first quantum key distribution device with a connection cable to provide a communication path between the classical device and the first quantum key distribution device, and a quantum channel carrier engaging the connection cable. The quantum channel carrier is configured to, responsive to movement of the connection cable, disrupt a quantum state within the quantum channel. |
| FILED | Thursday, September 12, 2019 |
| APPL NO | 16/569272 |
| ART UNIT | 2636 — Optical Communications |
| CURRENT CPC | Transmission H04B 10/25 (20130101) H04B 10/70 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0858 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 11135582 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178824 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 2400/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11136453 | Cwiertny et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | David Michael Cwiertny (Iowa City, Iowa); Nosang Vincent Myung (Riverside, California); Katherine Tanya Peter (Iowa City, Iowa); Katherine Elizabeth Greenstein (Iowa City, Iowa); Gene Francis Parkin (Iowa City, Iowa) |
| ABSTRACT | Composites comprising polymeric nanofibers, metal oxide nanoparticles, and optional surface-segregating surfactants and precursor compositions are disclosed. Also disclosed are nonwoven mats formed from the composites and methods of making and using the composites. The composites enable the deployment of nanostructured materials for water treatment within a self-contained membrane with high water fluxes, as well as a number uses. |
| FILED | Friday, May 26, 2017 |
| APPL NO | 16/303807 |
| ART UNIT | 1764 — Organic Chemistry, Polymers, Compositions |
| CURRENT CPC | Separation B01D 39/1623 (20130101) B01D 39/2079 (20130101) B01D 2239/025 (20130101) B01D 2239/0631 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) C08K 3/041 (20170501) C08K 5/19 (20130101) C08K 2003/2227 (20130101) C08K 2003/2268 (20130101) C08K 2003/2272 (20130101) Compositions of Macromolecular Compounds C08L 33/20 (20130101) Original (OR) Class Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/43 (20130101) D04H 1/4242 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 11136688 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Li Yang (Crestwood, Kentucky); Yan Wu (Louisville, Kentucky); Christopher O'Neil (Louisville, Kentucky); Austin Lassell (Georgetown, Kentucky); Hengfeng Gu (South Jordan, Utah) |
| ABSTRACT | Systems and processes for treating surfaces of metal components are provided. The systems can include a container for containing a metal workpiece having a surface with a complex external geometry and for containing a solution that has electrolytes at a flow rate that varies according to a local shape of the surface to thereby treat the surface of the metal workpiece; optionally one or more electrodes for creating an electrical field; and optionally a temperature control device configured to provide a predetermined temperature or range of temperatures. The processes can include providing a metal workpiece having a surface with a complex external geometry; and contacting the workpiece in the presence of a predetermined electrical field at a predetermined temperature with a solution containing electrolytes at a flow rate that varies according to a local shape of the surface to thereby treat the surface of the metal workpiece. |
| FILED | Thursday, August 08, 2019 |
| APPL NO | 16/536164 |
| ART UNIT | 1794 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/16 (20130101) Original (OR) Class C25F 3/26 (20130101) C25F 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139086 | Howe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HOWE INDUSTRIES, LLC (Tempe, Arizona) |
| ASSIGNEE(S) | HOWE INDUSTRIES, LLC (Scottsdale, Arizona) |
| INVENTOR(S) | Troy M. Howe (Tempe, Arizona); Steven D. Howe (Tempe, Arizona) |
| ABSTRACT | A customizable thin plate fuel form and reactor core therefor are disclosed. The thin plate fuel will comprise a fuel material embedded within a matrix material, with the entire unit having a coating. The thin plate fuel may be flat or curved and will have flow channels formed within at least the top surface of the fuel plate. The structure of the thin plate fuel will make it easier for coating with Tungsten or any other suitable material that will help contain any byproducts, prevent reactions with the working fluid, and potentially provide structural support to the thin plate fuel. |
| FILED | Thursday, December 07, 2017 |
| APPL NO | 15/834922 |
| ART UNIT | 3646 — Aeronautics, Agriculture, Fishing, Trapping, Vermin Destroying, Plant and Animal Husbandry, Weaponry, Nuclear Systems, and License and Review |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/408 (20130101) Nuclear Reactors G21C 3/20 (20130101) G21C 3/36 (20130101) Original (OR) Class G21C 3/64 (20130101) G21C 3/626 (20130101) G21C 5/16 (20130101) G21C 5/18 (20130101) G21C 5/126 (20130101) G21C 15/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Classified Government Agency
| US 11139217 | Zimmerman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Jeffrey A. Zimmerman (Manassas, Virginia); Landon J. Caley (Fredricksburg, Virginia); Richard J. Ferguson (Bealeton, Virginia) |
| ABSTRACT | A method for modifying a portion of a substrate after production is described herein. The method can include diagnosing a circuit operation error causing a malfunction, identifying a first contact on the substrate, and connecting, electrically, the first contact to a second contact with at least one trace. The trace is done with a focused ion beam. The method can include diagnosing an error on an operative area of a post-manufacture circuit board causing a malfunction; introducing a metal precursor into a focused ion beam chamber; ionizing the metal precursor by contacting it with a gallium ion beam into a conductive metal and a further ion; depositing a first portion of a conductive metal onto a substrate to form a first trace; and forming the first trace between the operative area and a non-operative area thereby connecting the operative area and the non-operative area. |
| FILED | Monday, September 09, 2019 |
| APPL NO | 16/564676 |
| ART UNIT | 1715 — Coating, Etching, Cleaning, Single Crystal Growth |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 5/12 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/14 (20130101) C23C 14/221 (20130101) C23C 16/06 (20130101) C23C 16/047 (20130101) C23C 16/486 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/485 (20130101) H01L 22/22 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 3/225 (20130101) H05K 2203/092 (20130101) H05K 2203/162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 11136355 | Vu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | NUtech Ventures (Lincoln, Nebraska) |
| INVENTOR(S) | Hiep Lai Xuan Vu (Lincoln, Nebraska); Fernando Osorio (Lincoln, Nebraska); William W. Laegreid (Laramie, Wyoming); Asit K. Pattnaik (Lincoln, Nebraska); Fangrui Ma (Lincoln, Nebraska) |
| ABSTRACT | A non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) is provided herein, and methods of making and using the non-naturally occurring PRRSV also are provided. |
| FILED | Thursday, May 28, 2020 |
| APPL NO | 16/886387 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/552 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/10021 (20130101) C12N 2770/10022 (20130101) C12N 2770/10034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 11140476 | Chiu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Norman Chiu (New York, New York); Paul Goldhagen (New York, New York) |
| ABSTRACT | In an example, a circuit includes: an AC piezoelectric audio transducer configured to receive an audio output signal of a source; a step-up transformer having a primary winding to receive the audio output signal of the source; a bridge rectifier having an input connected to a secondary winding of the step-up transformer; and a DC piezoelectric audio transducer connected to an output of the bridge rectifier. The AC piezoelectric audio transducer, the step-up transformer, the bridge rectifier, and the DC piezoelectric audio transducer are configured to produce an audible alarm signal based on the audio output signal of the source without powered amplification, which includes an audible sound from the AC piezoelectric audio transducer and another audible sound from the DC piezoelectric audio transducer. |
| FILED | Tuesday, February 23, 2021 |
| APPL NO | 17/182995 |
| ART UNIT | 2688 — Dynamic Storage Systems; Mechanical parts of Disk Drives |
| CURRENT CPC | Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 3/10 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/14 (20130101) H02M 7/06 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 3/00 (20130101) Original (OR) Class H04R 17/00 (20130101) H04R 29/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 11136053 | Plotnikov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GE Global Sourcing LLC (Norwalk, Connecticut) |
| ASSIGNEE(S) | TRANSPORTATION IP HOLDINGS, LLC (Norwalk, Connecticut) |
| INVENTOR(S) | Yuri Alexeyevich Plotnikov (Niskayuna, New York); Brett Alexander Matthews (Niskayuna, New York); Ajith Kuttannair Kumar (Erie, Pennsylvania); Jeffrey Michael Fries (Grain Valley, New York); Joseph Forrest Noffsinger (Grain Valley, New York); Samhitha Palanganda Poonacha (Bangalore, India); Tannous Frangieh (Niskayuna, New York); Frederick Wilson Wheeler (Niskayuna, New York); Brian Lee Staton (Palm Bay, Florida); Timothy Robert Brown (Erie, Pennsylvania); Gregory Boverman (Niskayuna, New York); Majid Nayeri (Niskayuna, New York) |
| ABSTRACT | Systems for examining a route inject one or more electrical examination signals into a conductive route from onboard a vehicle system traveling along the route, detect one or more electrical characteristics of the route based on the one or more electrical examination signals, and detect a break in conductivity of the route responsive to the one or more electrical characteristics decreasing by more than a designated drop threshold for a time period within a designated drop time period. Feature vectors may be determined for the electrical characteristics and compared to one or more patterns in order to distinguish between breaks in the conductivity of the route and other causes for changes in the electrical characteristics. |
| FILED | Wednesday, July 10, 2019 |
| APPL NO | 16/507919 |
| ART UNIT | 3669 — Computerized Vehicle Controls and Navigation, Radio Wave, Optical and Acoustic Wave Communication, Robotics, and Nuclear Systems |
| CURRENT CPC | Guiding Railway Traffic; Ensuring the Safety of Railway Traffic B61L 3/08 (20130101) B61L 3/10 (20130101) B61L 23/34 (20130101) B61L 23/044 (20130101) Original (OR) Class B61L 23/045 (20130101) B61L 2205/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 11138500 | Mountain |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States as represented by the Director, National Security Agency (Ft. George G. Meade, Maryland) |
| ASSIGNEE(S) | U.S. Government as represented by the Director, National Security Agency (Washington, District of Columbia) |
| INVENTOR(S) | David J. Mountain (Baltimore, Maryland) |
| ABSTRACT | A computer processor includes an on-chip network and a plurality of tiles. Each tile includes an input circuit to receive a voltage signal from the network, and a crossbar array, including at least one neuron. The neuron includes first and second bit lines, a programmable resistor connecting the voltage signal to the first bit line, and a comparator to receive inputs from the two bit lines and to output a voltage, when a bypass condition is not active. Each tile includes a programming circuit to set a resistance value of the resistor, a pass-through circuit to provide the voltage signal to an input circuit of a first additional tile, when a pass-through condition is active, a bypass circuit to provide values of the bit lines to a second additional tile, when the bypass condition is active; and at least one output circuit to provide an output signal to the network. |
| FILED | Tuesday, March 05, 2019 |
| APPL NO | 16/293020 |
| ART UNIT | 2842 — Electrical Circuits and Systems |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) G06N 3/0635 (20130101) Original (OR) Class Static Stores G11C 13/0069 (20130101) Amplifiers H03F 3/45269 (20130101) Pulse Technique H03K 5/2481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 11135582 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| INVENTOR(S) | David K. Schaffer (Nashville, Tennessee); Dmitry A. Markov (Nashville, Tennessee); Ronald S. Reiserer (Nashville, Tennessee); Lisa McCawley (Nashville, Tennessee); Michael Geuy (Nashville, Tennessee); Clayton M. Britt (Franklin, Kentucky); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | The invention relates to a cartridge of a fluidic device. The fluidic device includes a fluidic chip, a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a fluidic chip registration means formed on the first surface for aligning the fluidic chip with a support structure; and an actuator configured to engage with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flowrates. |
| FILED | Thursday, February 18, 2021 |
| APPL NO | 17/178824 |
| ART UNIT | 1797 — Food, Analytical Chemistry, Sterilization, Biochemistry, Electrochemistry |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/527 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502738 (20130101) B01L 3/502746 (20130101) B01L 2400/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 11134950 | Blatter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advent Access Pte. Ltd. (Singapore, Singapore) |
| ASSIGNEE(S) | Advent Access Pte. Ltd. (Singapore, Singapore) |
| INVENTOR(S) | Duane D. Blatter (Salt Lake, Utah); Trent J. Perry (Kaysville, Utah); Nathaniel P. Young (Salt Lake City, Utah); Jeffrey E. Ransden (Fairfield, Connecticut) |
| ABSTRACT | A method of attaching an implant to a vessel can include clamping a portion of a wall of a vessel within a patient. The method can also include positioning an implant adjacent to an outer surface of the wall of the vessel, and the implant can include an access port. The method can also include cutting the wall of the vessel about the portion of the wall that has been clamped, passing the portion of the wall that has been clamped and that has been cut about through the implant to remove the portion of the wall from the patient and to provide an opening in the vessel, and securing the implant to the vessel such that the access port is in direct fluid communication with an interior of the vessel via the opening in the vessel. |
| FILED | Wednesday, March 13, 2019 |
| APPL NO | 16/352693 |
| ART UNIT | 3771 — Medical & Surgical Instruments, Treatment Devices, Surgery and Surgical Supplies |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/11 (20130101) Original (OR) Class A61B 17/115 (20130101) A61B 17/0218 (20130101) A61B 2017/1107 (20130101) A61B 2017/1135 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 39/02 (20130101) A61M 39/0247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 11135282 | Marasco |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Wayne A. Marasco (Wellesley, Massachusetts) |
| ABSTRACT | The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection. |
| FILED | Friday, April 08, 2016 |
| APPL NO | 15/564897 |
| ART UNIT | 1648 — Immunology, Receptor/Ligands, Cytokines Recombinant Hormones, and Molecular Biology |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/1018 (20130101) C07K 2317/21 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 11139883 | Zalucki et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc (Nashua, New Hampshire) |
| INVENTOR(S) | Michael A. Zalucki (Hollis, New Hampshire); Tyler Hayslett (Nashua, New Hampshire) |
| ABSTRACT | A combined spatial and time multiplexer device is disclosed. The device organizes and selects any signal(s), including past data, from amongst a plurality of time division multiplexed (TDM) data streams. The data streams are collected by memory devices that are configured to separately store the multiplexed signals such that different time portions of the signals from each data stream are stored in different addressable sections. This allows for the current time data and past time data for a given signal to be selected and outputted by the device. According to an embodiment, each of the memory devices receives an address select signal and selects a signal group based on the address select signal. The device also includes a multiplexer that selects one of the signal groups from amongst the memory devices to output as the requested signal group. |
| FILED | Friday, September 11, 2020 |
| APPL NO | 17/018308 |
| ART UNIT | 2633 — Digital Communications |
| CURRENT CPC | Transmission H04B 7/0891 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0025 (20130101) Wireless Communication Networks H04W 72/046 (20130101) H04W 72/0446 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Tuesday, October 05, 2021.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week’s taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract as it appears on the patent.
FILED
The date of the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full-text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page