FedInvent™ Patent Applications

Application Details for Thursday, January 13, 2022 

This page was updated on Monday, January 17, 2022 at 04:35 PM GMT

Department of Health and Human Services (HHS) 

US 20220007939 Dave et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) PlenOptika, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Shivang R. Dave (Boston, Massachusetts);  Daryl Lim (Singapore, Singapore);  Nicholas James Durr (Baltimore, Maryland)
ABSTRACT An apparatus, and corresponding method, for determining a property of an eye includes a housing with a proximal port that receives an eye and also light from the eye. The housing further includes a distal port, and the two ports together form a visual channel providing an open view to enable the eye to see target indicia external to and spaced away from the housing. A wavefront sensor within the housing is configured to receive the light from the eye via the optical path and to measure a wavefront of the light. A determination module determines an objective refractive correction based on the wavefront and predicts a subjective refractive preference of a person having the eye based on the objective refractive correction. Embodiments can be handheld, and binocular, and predict subjective refraction based on demographic and other information.
FILED Tuesday, July 20, 2021
APPL NO 17/380891
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 3/005 (20130101)
A61B 3/0008 (20130101)
A61B 3/09 (20130101)
A61B 3/18 (20130101) Original (OR) Class
A61B 3/028 (20130101)
A61B 3/0033 (20130101)
A61B 3/103 (20130101)
A61B 3/0285 (20130101)
A61B 3/1208 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220007943 Sanchez et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) ENSPECTRA HEALTH, INC. (Mountain View, California)
ASSIGNEE(S)
INVENTOR(S) Gabriel Sanchez (Menlo Park, California);  Fred Landavazo, IV (Redwood City, California);  Kathryn Montgomery (Mountain View, California);  Piyush Arora (San Carlos, California)
ABSTRACT Provided herein are methods, devices, and systems that may improve optical resolution when imaging through a thickness of samples. A method for generating a depth profile of a tissue of a subject may comprise using an optical probe to transmit an excitation light beam from a light source towards a surface of the tissue; using one or more focusing units in the optical probe to simultaneously adjust a depth and a position of a focal point of the excitation light beam along a scanning path; detecting at least a subset of the signals generated upon contacting the tissue with the excitation light beam; and using one or more computer processors programmed to process the at least the subset of the signals to generate the depth profile of the tissue.
FILED Tuesday, May 11, 2021
APPL NO 17/317661
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0071 (20130101)
A61B 5/0075 (20130101) Original (OR) Class
A61B 5/0084 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 2207/10016 (20130101)
G06T 2207/10028 (20130101)
G06T 2207/30024 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220007969 Balter et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) James Balter (Ann Arbor, Michigan);  Yue Cao (Ann Arbor, Michigan);  Lianli Liu (Ann Arbor, Michigan);  Adam Johnsson (Uppsala, Sweden)
ABSTRACT The following relates generally to motion prediction in magnetic resonance (MR) imaging. In some embodiments, a “modular” approach is taken to motion correction. That is, individual motion sources (e.g., a patient's breathing, heartbeat, stomach contractions, peristalsis, and so forth) are accounted for individually in the motion correction. In some embodiments, to correct for a particular motion source, a reference state is created from a volume of interest (VOI), and other states are created and deformably aligned to the reference state.
FILED Wednesday, June 30, 2021
APPL NO 17/364845
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/113 (20130101)
A61B 5/1107 (20130101) Original (OR) Class
A61B 5/1128 (20130101)
A61B 6/466 (20130101)
A61B 6/4042 (20130101)

Image Data Processing or Generation, in General
G06T 7/207 (20170101)
G06T 2207/10088 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220007991 ROBERTS et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) The Trustees of Dartmouth College (Hanover, New Hampshire)
ASSIGNEE(S)
INVENTOR(S) David W. ROBERTS (Lyme, New Hampshire);  Keith D. PAULSEN (Hanover, New Hampshire);  Alexander HARTOV (Enfield, New Hampshire);  Songbai JI (Hanover, New Hampshire);  Xiaoyao FAN (Lebanon, New Hampshire)
ABSTRACT A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.
FILED Monday, September 27, 2021
APPL NO 17/486839
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0042 (20130101)
A61B 5/0077 (20130101)
A61B 5/377 (20210101) Original (OR) Class
A61B 2034/104 (20160201)

Image Data Processing or Generation, in General
G06T 3/0068 (20130101)
G06T 7/33 (20170101)

Pictorial Communication, e.g Television
H04N 13/239 (20180501)
H04N 13/257 (20180501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220007997 MANNOH et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Emmanuel A. MANNOH (Nashville, Tennessee);  Anita MAHADEVAN-JANSEN (Nashville, Tennessee)
ABSTRACT A combined auto-fluorescence imaging and laser speckle contrast imaging (LSCI) system to enable intra-operative parathyroid identification and viability assessment with the same tool. The system includes a light source for emitting a beam of light to illuminate a target of interest, and an imaging head positioned over the target of interest for individually acquiring auto-fluorescence images and LSCI images of light from the illuminated target of interest responsive to the illumination. Auto-fluorescence imaging helps identify the parathyroid, while LSCI helps assess its viability.
FILED Monday, November 04, 2019
APPL NO 17/289323
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0071 (20130101)
A61B 5/0075 (20130101)
A61B 5/0086 (20130101)
A61B 5/415 (20130101) Original (OR) Class
A61B 5/418 (20130101)
A61B 5/742 (20130101)
A61B 5/4227 (20130101)
A61B 34/20 (20160201)
A61B 2034/2055 (20160201)
A61B 2505/05 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/65 (20130101)
G01N 21/6456 (20130101)
G01N 2021/6439 (20130101)
G01N 2201/0221 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008060 Gittard et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Muffin Incorporated (West Lafayette, Indiana);  National Institutes of Health, an Agency of the Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) Muffin Incorporated (West Lafayette, Indiana);  National Institutes of Health, an Agency of the Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Shaun Davis Gittard (Winston-Salem, North Carolina);  Gregory James Hardy (Asheville, North Carolina);  John C. Sigmon, JR. (Winston-Salem, North Carolina);  Jeremy T. Newkirk (West Lafayette, Indiana);  William J. Havel (West Lafayette, Indiana);  Neal E. Fearnot (West Lafayette, Indiana);  Toby Rogers (Washington, District of Columbia);  Kanishka Ratnayaka (Bethesda, Maryland);  Robert L. Lederman (Chevy Chase, Maryland)
ABSTRACT Among other things, there is disclosed structure and methods for maintaining access to a location in the body while reducing or eliminating the potential for pulling an access device (e.g. a catheter) back through an opening. An introducer sheath includes a distal indented portion and a balloon, so that once placed in a desired location through tissue, the balloon can be inflated to anchor the sheath against retraction. In particular embodiments, structure and methods for accessing the pericardial cavity via the right atrial appendage are shown.
FILED Monday, July 26, 2021
APPL NO 17/385230
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 17/0218 (20130101) Original (OR) Class
A61B 90/39 (20160201)
A61B 2017/3486 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 25/10 (20130101)
A61M 25/0041 (20130101)
A61M 25/0045 (20130101)
A61M 2025/0047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008346 Wilson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Congressionally Directed Medical Research Programs (CDMRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) John T. Wilson (Nashville, Tennessee);  Daniel Shae (Nashville, Tennessee);  Dinh Chuong Nguyen (Phu Nhuan District, Ho Chi Minh, Viet Nam)
ABSTRACT A graft copolymer and a method of delivering an active agent to a subject are provided. The graft copolymer includes a polymer backbone, a hydrophilic segment grafted to the polymer backbone, a pH-responsive segment grafted to the polymer backbone, and an endosomal disruption segment grafted to the polymer backbone. The method of delivering an active agent to a subject includes encapsulating the active agent with the graft copolymer and administering the encapsulated active agent to the subject.
FILED Wednesday, October 30, 2019
APPL NO 17/290618
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5026 (20130101) Original (OR) Class

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 290/062 (20130101)
C08F 2438/03 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008350 VISHWANATHA et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) University of North Texas Health Science Center (Fort Worth, Texas)
ASSIGNEE(S) University of North Texas Health Science Center (Fort Worth, Texas)
INVENTOR(S) Jamboor K. VISHWANATHA (Fort Worth, Texas);  Andrew GDOWSKI (Fort Worth, Texas);  Amalendu Prakash RANJAN (Fort Worth, Texas);  Anindita MUKERJEE (Fort Worth, Texas)
ABSTRACT Certain embodiments are directed to methods for making programmable bioinspired nanoparticles (P-BiNP). Nanoparticles are coated with a cell membrane derived from a cell stimulated to express or overexpress a protein identified as being expressed in a target cell, forming a homotypic and organ targeted nanoparticle delivery vehicle.
FILED Wednesday, October 16, 2019
APPL NO 17/309030
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5153 (20130101)
A61K 9/5176 (20130101) Original (OR) Class
A61K 9/5192 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008365 Daniels et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Anthony B. Daniels (Nashville, Tennessee);  Debra L. Friedman (Nashville, Tennessee)
ABSTRACT Methods of treating a proliferative conditions of the eye, comprising administering to a patient a therapeutically effective amount of a composition that comprises a compound that inhibits the biological activity of a mammalian histone deacetylase (HDAC), or a pharmaceutically acceptable salt thereof; and a pharmaceutical carrier.
FILED Thursday, November 14, 2019
APPL NO 17/294339
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/165 (20130101) Original (OR) Class
A61K 31/4045 (20130101)
A61K 31/4406 (20130101)
A61K 38/15 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008368 CHUN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
ASSIGNEE(S) PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts)
INVENTOR(S) Eunyoung CHUN (Brookline, Massachusetts);  Wendy Sarah GARRETT (Brookline, Massachusetts)
ABSTRACT Described herein are methods, assays, and compositions and uses thereof related to treating, preventing, and detecting a gastrointestinal disease with an agent that targets Ffar2. The agents described herein can further increase populations of group 3 innate lymphoid cells (ILC3s) in the gut.
FILED Thursday, November 14, 2019
APPL NO 17/293840
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/19 (20130101) Original (OR) Class
A61K 31/426 (20130101)
A61K 31/513 (20130101)
A61K 38/177 (20130101)
A61K 48/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/04 (20180101)
A61P 29/00 (20180101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/92 (20130101)
G01N 33/5047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008376 LU
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Maryland, Baltimore (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Wuyuan LU (Clarkville, Maryland)
ABSTRACT Type 3 Secretion System (T3 SS) inhibitors, tanshinones and tanshinone analogs, and methods of using the same for the treatment of disease are disclosed. The invention relates generally to antibiotic compounds and methods of treating or preventing bacterial infections using the same, and more particularly, but not exclusively, to compounds that inhibit biogenesis of the Type 3 Secretion System (T3 SS) needle, including tanshinone and tanshinone analogs, and methods of using the same.
FILED Friday, November 01, 2019
APPL NO 17/290691
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/343 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008408 Zhou et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) DUKE UNIVERSITY (Durham, North Carolina)
ASSIGNEE(S) DUKE UNIVERSITY (Durham, North Carolina)
INVENTOR(S) Pei Zhou (Durham, North Carolina);  Jiyong Hong (Durham, North Carolina)
ABSTRACT This invention relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to translesion synthesis (TLS) pathway. More particularly, this disclosure relates to small molecule inhibitors of TLS, methods of inhibiting TLS pathway with these compounds, and methods of treating diseases related to the TLS pathway.
FILED Wednesday, October 09, 2019
APPL NO 17/283461
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4706 (20130101) Original (OR) Class
A61K 33/243 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008418 Rawat et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The McLean Hospital Corporation (Belmont, Massachusetts);  University of Delhi (Delhi, India)
ASSIGNEE(S)
INVENTOR(S) Diwan S. Rawat (Delhi, India);  Sunny Manohar (Delhi, India);  Ummadisetty Chinna Rajesh (Delhi, India);  DEEPAK KUMAR (Delhi, India);  Anuj Thakur (Delhi, India);  Mohit Tripathi (Delhi, India);  Panyala Linga Reddy (Delhi, India);  Shamseer Kulangara Kandi (Delhi, India);  Satyapavan Vardhineni (Delhi, India);  Kwang-Soo Kim (Lexington, Massachusetts);  Chun-Hyung Kim (Lexington, Massachusetts)
ABSTRACT Described herein are aminoquinoline and aminoacridine based hybrids, pharmaceutical compositions and medicaments that include such aminoquinoline and aminoacridine based hybrids, and methods of using such compounds for diagnosing and/or treating infections, neurodegerative diseases or disorders, inflammation, inflammation associated diseases and disorders, and/or diseases or disorders that are treatable with dopamine agonists such as the restless leg syndrome.
FILED Monday, April 26, 2021
APPL NO 17/240886
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/506 (20130101) Original (OR) Class
A61K 31/5355 (20130101)
A61K 31/5377 (20130101)
A61K 45/06 (20130101)

Heterocyclic Compounds
C07D 401/12 (20130101)
C07D 401/14 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0619 (20130101)
C12N 2506/02 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008420 BRADNER et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts);  DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S) THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts);  DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S) James BRADNER (Weston, Massachusetts);  Jun QI (Sharon, Massachusetts);  Dennis BUCKLEY (Cambridge, Massachusetts);  Leonard I. ZON (Brookline, Massachusetts);  Elizabeth MACARI (Wilmington, Massachusetts)
ABSTRACT The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.
FILED Friday, February 12, 2021
APPL NO 17/175079
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/55 (20130101)
A61K 31/225 (20130101)
A61K 31/403 (20130101)
A61K 31/506 (20130101)
A61K 31/517 (20130101) Original (OR) Class
A61K 31/519 (20130101)
A61K 31/5415 (20130101)
A61K 31/7048 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 7/06 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008429 UEHARA et al.
FUNDED BY
Department of Health and Human Services (HHS)
Assistant Secretary for Preparedness and Response (ASPR)
Biomedical Advanced Research and Development Authority (BARDA)
APPLICANT(S) Shionogi and Co., Ltd. (Osaka-shi, Osaka, Japan);  F. HOFFMANN-LA ROCHE AG (Basel, Switzerland)
ASSIGNEE(S)
INVENTOR(S) Takeki UEHARA (Osaka, Japan);  Toru ISHIBASHI (Osaka, Japan);  Takao SHISHIDO (Osaka, Japan);  Keita FUKAO (Osaka, Japan);  Motoyasu OONISHI (Osaka, Japan);  Barry CLINCH (Welwyn Garden City, United Kingdom);  Jaspinder RANDHAWA (Welwyn Garden City, United Kingdom)
ABSTRACT A method for treating an influenza virus infection is described. The disclosed method generally involves administering an effective amount of a compound (A), for example baloxavir marboxil, and a compound (B), for example a neuraminidase inhibor, to a subject that (1) has an influenza virus infection, (2) has been symptomatic of the influenza virus infection for no more than 96 hours, and (3) further has at least one severe influenza condition selected from the following: (a) being hospitalized due to severe influenza virus infection, (b) requiring an extension of hospitalization because of the influenza virus infection during the hospitalization, (c) having a National Early Warning Score 2 of four or more, (d) being on support for respiration, and (e) having at least one complication attributable to the influenza virus infection that necessitates hospitalization.
FILED Friday, March 20, 2020
APPL NO 16/825263
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/215 (20130101)
A61K 31/5383 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008433 Edge et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Massachusetts Eye and Ear Infirmary (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Albert Edge (Brookline, Massachusetts);  Niliksha Gunewardene (Boston, Massachusetts)
ABSTRACT Methods for the generation of sensorineural hair cells, and more particularly to the use of epigenetic modulation of Atoh1 expression using a combination of Histone Lysine Demethylase (KDM) inhibitors and Wnt activators to generate sensorineural hair cells.
FILED Tuesday, November 26, 2019
APPL NO 17/296764
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/55 (20130101) Original (OR) Class
A61K 31/137 (20130101)
A61K 31/506 (20130101)
A61K 45/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008442 Otto et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Mario Otto (Fitchburg, Wisconsin);  Dana C. Baiu (Madison, Wisconsin);  Bryan P. Bednarz (Madison, Wisconsin);  Jamey Paul Weichert (Sun Prairie, Wisconsin)
ABSTRACT It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by malignant pediatric tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and R2 is —N+(CH3)3. The compounds can be used to treat pediatric solid tumors or to detect pediatric solid tumors. In therapeutic treatment, R1 includes a radioactive iodine isotope that locally delivers therapeutic dosages of radiation to the malignant pediatric tumor cells that preferentially take up the compound. In detection/imaging applications, R1 includes a detection moiety, such as a fluorophore or a radioactive iodine isotope.
FILED Tuesday, September 21, 2021
APPL NO 17/480239
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/69 (20130101)
A61K 31/685 (20130101) Original (OR) Class
A61K 31/6615 (20130101)
A61K 33/18 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57407 (20130101)
G01N 33/57484 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008443 O'CONNOR et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
Fogarty International Center (FIC)
National Center for Complementary and Integrative Health (NCCIH)
APPLICANT(S) Washington State University (Pullman, Washington);  Tufts Medical Center, Inc. (Boston, Massachusetts);  University of Utah Research Foundation (Salt Lake City, Utah)
ASSIGNEE(S)
INVENTOR(S) Roberta O'CONNOR (Pullman, Washington);  Eric W. SCHMIDT (Salt Lake City, Utah)
ABSTRACT Methods and compositions for preventing and/or treating diseases and conditions caused by certain apicomplexan infections are provided. The methods involve administering/providing to a subject one or more of tartrolon D and E, including isomers thereof. Exemplary apicomplexan infections that are prevented/treated by the compounds of the invention include those caused by Cryptosporidium, Babesia, Cyclospora, Isospora, Plasmodium, Sarcocystis, Besnoitia, Hammondia, Neospora, Theileria and Toxoplasma.
FILED Friday, August 27, 2021
APPL NO 17/459985
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/69 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 33/06 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008452 CHUN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) YALE UNIVERSITY (NEW HAVEN, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Hyung CHUN (Guilford, Connecticut);  Takaomi ADACHI (East Haven, Connecticut)
ABSTRACT In various aspects and embodiments the invention provides compositions and methods useful in the treatment of certain metabolic diseases, such as but not limited to NASH, NAFLD, diabetes, atherosclerosis, and/or obesity.
FILED Friday, December 06, 2019
APPL NO 17/311502
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7105 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/04 (20180101)
A61P 3/10 (20180101)
A61P 9/10 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008500 Kay et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The George Washington University (Washington, District of Columbia);  The U.S. Government as represented by The Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Matthew Kay (Kensington, Maryland);  Kara Garrott (Washington, District of Columbia);  Jhansi Dyavanapalli (Gaithersburg, Maryland);  David Mendelowitz (Vienna, Virginia);  Gregory Trachiotis (Arlington, Virginia)
ABSTRACT Methods of treating a subject having heart failure including heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, and left ventricular hypertrophy-induced heart failure. The methods include activating hypothalamic oxytocin neurons in the brain of the subject and/or administering intranasally to the subject a therapeutically effective amount of oxytocin. Intranasal formulations for the treatment of a subject diagnosed with heart failure are also provided.
FILED Wednesday, June 16, 2021
APPL NO 17/349771
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0043 (20130101)
A61K 38/095 (20190101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/10 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008504 Fang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Methodist Hospital (Houston, Texas)
ASSIGNEE(S) The Methodist Hospital (Houston, Texas)
INVENTOR(S) Longhou Fang (Katy, Texas);  Qilin Gu (Quincy, Massachusetts)
ABSTRACT Embodiments of the present disclosure pertain to methods of reducing hematopoiesis in a subject by administering to the subject a therapeutically effective amount of an inhibitor of Srebp2. Additional embodiments of the present disclosure pertain to compositions for reducing hematopoiesis in a subject. In some embodiments, the compositions include a therapeutically effective amount of an inhibitor of Srebp2. Further embodiments of the present disclosure pertain to methods of enhancing hematopoiesis in a subject by administering to the subject a therapeutically effective amount of an active ingredient. Additional embodiments of the present disclosure pertain to compositions for enhancing hematopoiesis in a subject. In some embodiments, the compositions of the present disclosure include active ingredients that enhance hematopoiesis in the subject.
FILED Wednesday, January 29, 2020
APPL NO 17/297543
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/22 (20130101)
A61K 31/40 (20130101)
A61K 31/047 (20130101)
A61K 31/47 (20130101)
A61K 31/366 (20130101)
A61K 31/405 (20130101)
A61K 31/505 (20130101)
A61K 31/4418 (20130101)
A61K 31/4439 (20130101)
A61K 31/7105 (20130101)
A61K 38/177 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 7/06 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008512 SHIRWAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (Louisville, Kentucky);  FASCURE THERAPEUTICS, LLC (Louisville, Kentucky)
ASSIGNEE(S) UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (Louisville, Kentucky);  FASCURE THERAPEUTICS, LLC (Louisville, Kentucky)
INVENTOR(S) Haval SHIRWAN (Columbia, Missouri);  Esma S. YOLCU (Columbia, Missouri);  Rajesh SHARM (San Diego, California)
ABSTRACT Described herein are methods for treating and preventing cancer. In particular, described herein are methods using SA-4-1BBL as a monotherapy agent to treat, prevent or reduce the risk of cancer, treat, prevent, or reduce the risk of tumorigenesis, and treat, prevent, or reduce the risk of post-surgical tumor recurrence. SA-4-1BBL for use as a monotherapy in such methods also is provided.
FILED Friday, November 15, 2019
APPL NO 17/294157
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 38/191 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008520 Ambrosio et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Fabrisia Ambrosio (Pittsburgh, Pennsylvania);  Aaron Barchowsky (Pittsburgh, Pennsylvania);  Amin Cheikhi (Pittsburgh, Pennsylvania);  Rada Koldamova (Bethel Park, Pennsylvania);  Iliya Lefterov (Bethel Park, Pennsylvania);  Amrita Sahu (Pittsburgh, Pennsylvania)
ABSTRACT This document provides methods and materials for treating aging. For example, a mammal having, or at risk for developing, an age-related impairment (e.g., age-related cognitive decline) can be treated by increasing the level of one or more myokine polypeptides (e.g., one or more Klotho polypeptides) within cells within the mammal. This document also provides methods and materials for increasing the ability of muscle progenitor cells to regenerate muscle cells by increasing the level(s) of one or more myokine polypeptides (e.g., an α-Klotho polypeptide) within a muscle progenitor cell.
FILED Thursday, November 21, 2019
APPL NO 17/294726
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/127 (20130101)
A61K 38/47 (20130101) Original (OR) Class
A61K 48/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/06 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008523 Shea et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Lonnie D. Shea (Evanston, Illinois);  Stephen D. Miller (Evanston, Illinois);  Jonathan Woon Teck Yap (Evanston, Illinois);  Daniel R. Getts (Northbrook, Illinois);  Derrick McCarthy (Evanston, Illinois)
ABSTRACT The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
FILED Wednesday, September 22, 2021
APPL NO 17/482043
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/19 (20130101)
A61K 9/1647 (20130101)
A61K 9/5153 (20130101)
A61K 39/00 (20130101)
A61K 39/0008 (20130101) Original (OR) Class
A61K 47/58 (20170801)
A61K 47/6911 (20170801)
A61K 47/6935 (20170801)
A61K 47/6937 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008535 Zaghouani
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Curators of the University of Missouri (Columbia, Missouri)
ASSIGNEE(S)
INVENTOR(S) Habib Zaghouani (Columbia, Missouri)
ABSTRACT The disclosure relates generally to methods and compositions of treating or preventing diabetes mellitus by administering to a subject a composition comprising an amount of stem and/or progenitor cells and at least one antigen-specific therapy.
FILED Friday, September 03, 2021
APPL NO 17/466097
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/28 (20130101)
A61K 35/545 (20130101)
A61K 38/10 (20130101)
A61K 38/51 (20130101)
A61K 38/1774 (20130101)
A61K 39/39533 (20130101) Original (OR) Class
A61K 2039/505 (20130101)

Peptides
C07K 16/18 (20130101)
C07K 2318/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008543 Wang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Board of Regents of the University of Nebraska (Lincoln, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Dong Wang (Omaha, Nebraska);  Steven R. Goldring (Auburndale, Massachusetts);  Gang Zhao (Omaha, Nebraska);  Rongguo Ren (Omaha, Nebraska);  Zhenshan Jia (Omaha, Nebraska);  Xin Wei (Omaha, Nebraska)
ABSTRACT This application discloses prodrug-based thermosensitive gel (“ProGel”) comprised of conjugates of dmg molecules with water-soluble polymeric carriers, which are capable of controlled release of the dmg molecules into the tissue of a subject. Use of the ProGel-Drug conjugates for treatment of various diseases or disorders and methods of preparing them are also disclosed.
FILED Sunday, October 27, 2019
APPL NO 17/288814
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/55 (20170801)
A61K 47/58 (20170801) Original (OR) Class
A61K 47/545 (20170801)
A61K 47/554 (20170801)
A61K 47/6903 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008560 KAPILOFF et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) University of Miami (Miami, Florida);  The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) University of Miami (Miami, Florida);  The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) Michael KAPILOFF (Los Altos, California);  Jinliang LI (Palo Alto, California)
ABSTRACT The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAPβ. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAPβ to which PP2A binds.
FILED Friday, March 13, 2020
APPL NO 16/818771
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/761 (20130101)
A61K 48/0066 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/04 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008563 Mukherjee et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Jogeshwar Mukherjee (Irvine, California);  Christopher Liang (Irvine, California);  Phuc Quang Lam (Irvine, California);  Rommani Mondal (Chino Hills, California);  Stephanie Martinez (Irvine, California)
ABSTRACT The disclosure provides compounds for detecting neurodegeneration and/or identifying and monitoring the progression of inflammation in neurodegenerative diseases. The disclosure further provides compounds that inhibit the activity of monoamine oxidases, and uses thereof.
FILED Friday, July 09, 2021
APPL NO 17/372410
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 51/0455 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

General Methods of Organic Chemistry; Apparatus Therefor
C07B 59/002 (20130101)

Heterocyclic Compounds
C07D 471/04 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/60 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008567 Chilkoti et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Ashutosh Chilkoti (Durham, North Carolina);  Jeffrey L. Schaal (Durham, North Carolina);  Wenge Liu (Durham, North Carolina)
ABSTRACT Described herein are compositions for liquidly injectable, self-stabilizing biopolymers for the delivery of radionuclide brachytherapy. Also described herein are methods of using the compositions.
FILED Wednesday, November 13, 2019
APPL NO 17/294368
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 51/088 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008701 Langer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Brigham and Women's Hospital, Inc. (Boston, Massachusetts)
INVENTOR(S) Robert S. Langer (Newton, Massachusetts);  Carlo Giovanni Traverso (Newton, Massachusetts);  Ester Caffarel Salvador (Cambridge, Massachusetts);  Sahab Babaee (Arlington, Massachusetts);  Simo Pajovic (Mississauga, Canada)
ABSTRACT Systems and methods related to reconfigurable medical devices are described. In some embodiments, a reconfigurable medical device may include a central core and a plurality of arms. The arms may be rotatably coupled to the central core such that the plurality of arms may rotate outwards away from the central core to selectively reconfigure the reconfigurable device between a retracted configuration and an expanded configuration. In an initial state, the arms may be biased outwards away from the central core into the expanded configuration. When the reconfigurable device is exposed to a temperature greater than a threshold temperature, the arms may be biased towards the central core into the retracted configuration. In some embodiments, a reconfigurable medical device may include therapeutic compound-loaded needles coupled to distal portions of the arms.
FILED Friday, November 15, 2019
APPL NO 17/293799
CURRENT CPC
Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 31/002 (20130101) Original (OR) Class
A61M 37/00 (20130101)
A61M 2205/0266 (20130101)
A61M 2210/105 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008748 Huang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Charles Huang (San Diego, California);  Lei Xing (Palo Alto, California)
ABSTRACT A method for radiation therapy treatment planning includes: a) defining a decision variable search space by projecting an initial seed point onto a pareto front, where the pareto front and decision variable search space are defined in the same coordinate space; b) projecting search points in the decision variable search space to the pareto front using a one-dimensional search algorithm to produce projected points on the pareto front; c) updating the search points by performing a gradient-free optimization that evaluates a treatment planning scoring function at the projected points on the pareto front; and d) repeating steps (b), (c) to search within the decision variable search space until a convergence criterion is satisfied, thereby producing a pareto optimal and clinically acceptable treatment plan.
FILED Thursday, July 08, 2021
APPL NO 17/370383
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/1031 (20130101) Original (OR) Class
A61N 5/1077 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008926 Cameron et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S) The Penn State Research Foundation (University Park, Pennsylvania)
INVENTOR(S) Craig Eugene Cameron (State College, Pennsylvania);  Wu Liu (State College, Pennsylvania)
ABSTRACT The present invention provides microfluidic devices capable of sequestering single particles in individual microchambers and isolating the particles from one another. The devices provide a plurality of channels fluidly connected to a plurality of microchambers. A fluid suspension comprising particles of interest can be passed through the devices in a first direction to sequester single particles in each microchamber. An isolating fluid can be passed through the devices in a second, reverse direction to isolate the particles from one another. The devices can selectively isolate several particles in each microchamber.
FILED Tuesday, July 06, 2021
APPL NO 17/367827
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502761 (20130101) Original (OR) Class
B01L 2200/0652 (20130101)
B01L 2300/16 (20130101)
B01L 2300/168 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/405 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009124 Xiao et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Office of Fossil Energy and Carbon Management (FE)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Clemson University Research Foundation (Clemson, South Carolina)
ASSIGNEE(S)
INVENTOR(S) Hai Xiao (Clemson, South Carolina);  Jianhua Tong (Central, South Carolina);  Fei Peng (Clemson, South Carolina);  Kyle S. Brinkman (Clemson, South Carolina);  Shenglong Mu (Clemson, South Carolina);  Jincheng Lei (Clemson, South Carolina);  Yuzhe Hong (Clemson, South Carolina);  Hua Huang (Clemson, South Carolina);  Rajendra Bordia (Seneca, South Carolina)
ABSTRACT A method for fabricating a protonic ceramic energy device includes: coating an electrolyte layer on an anode layer; and densifying the electrolyte layer by a rapid laser reactive sintering (RLRS) process on the electrolyte layer and/or the anode layer to form a half-cell comprising a dense electrolyte and a porous anode.
FILED Wednesday, December 30, 2020
APPL NO 17/138173
CURRENT CPC
Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam
B23K 26/402 (20130101)
B23K 2103/52 (20180801)

Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster
B28B 1/001 (20130101) Original (OR) Class

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 40/20 (20200101)

Manufacture, Shaping, or Supplementary Processes
C03B 19/01 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009891 KWON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Oyhun KWON (Los Angeles, California);  Qihai XU (Los Angeles, California);  Nathan J. DUPPER (Los Angeles, California);  Jau-Nian CHEN (Los Angeles, California);  Adam D. LANGENBACHER (Los Angeles, California)
ABSTRACT R-aplexone, methods of preparing R-aplexone, or aplexone substantially free of its S-stereoisomer are disclosed. Methods of using R-aplexone or a pharmaceutically acceptable salt or solvate thereof to treat and/or prevent disease are disclosed. Methods of preparing 6-substituted tetrahydropyridine motifs with high enantiomeric excess are also disclosed.
FILED Thursday, September 19, 2019
APPL NO 17/278230
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Heterocyclic Compounds
C07D 211/96 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009905 ARANCIO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York);  Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Ottavio ARANCIO (New York, New York);  Daniel Martin WATTERSON (Douglas, Michigan);  Jeffrey Claude PELLETIER (Lafayette Hill, Pennsylvania);  Saktimayee Mitra ROY (Evanston, Illinois)
ABSTRACT The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.
FILED Thursday, September 16, 2021
APPL NO 17/476648
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Heterocyclic Compounds
C07D 401/04 (20130101)
C07D 401/14 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009914 Johnson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Trustees of Indiana University (Indianapolis, Indiana);  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S) Steven Johnson (Indianapolis, Indiana);  Eli Chapman (Tucson, Arizona)
ABSTRACT Novel compounds and methods of killing or inhibiting the growth of bacteria.
FILED Thursday, July 01, 2021
APPL NO 17/365390
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/04 (20180101)

Acyclic or Carbocyclic Compounds
C07C 251/86 (20130101)
C07C 2602/10 (20170501)

Heterocyclic Compounds
C07D 215/12 (20130101)
C07D 215/26 (20130101)
C07D 215/28 (20130101)
C07D 307/52 (20130101)
C07D 307/73 (20130101)
C07D 401/12 (20130101)
C07D 405/12 (20130101)
C07D 409/12 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009941 Natarajan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Amarnath Natarajan (Elkhorn, Nebraska);  Sandeep Rana (Omaha, Nebraska)
ABSTRACT Provided herein are compounds and methods for modulating the NFκB pathway. More particularly, provided are inhibitors of the NFκB pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.
FILED Wednesday, July 21, 2021
APPL NO 17/382083
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 487/10 (20130101)
C07D 491/107 (20130101) Original (OR) Class
C07D 519/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009967 Franzblau
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S) Scott G. Franzblau (Chicago, Illinois)
ABSTRACT Provided herein are compounds having a structure according to formula I, pharmaceutical compositions thereof, and methods of treating a bacterial infection thereof.
FILED Tuesday, July 13, 2021
APPL NO 17/305713
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 7/64 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009977 Cherqui
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Stephanie Cherqui (La Jolla, California)
ABSTRACT Provided herein are methods for treating a disease or disorder associated with mitochondrial dysfunction through ex vivo introduction of a nucleic acid molecule into hematopoietic stem and progenitor cells (HSPCs) followed by transplantation of the HSPCs into a subject in need of treatment. The nucleic acid molecule may include a functional human frataxin (hFXN) or may include a gene editing system that when transfected into the cells removes a trinucleotide extension mutation of endogenous hFXN.
FILED Friday, September 24, 2021
APPL NO 17/484324
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0276 (20130101)
A01K 67/0278 (20130101)
A01K 2207/15 (20130101)
A01K 2217/05 (20130101)
A01K 2217/15 (20130101)
A01K 2217/075 (20130101)
A01K 2227/105 (20130101)
A01K 2267/0318 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 35/28 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Peptides
C07K 14/47 (20130101) Original (OR) Class
C07K 2319/60 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/11 (20130101)
C12N 15/86 (20130101)
C12N 2310/20 (20170501)
C12N 2740/16043 (20130101)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009980 Zhuang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Zhengping Zhuang (Bethesda, Maryland);  Emeline Tabouret (Marseille, France);  Herui Wang (McLean, Virginia);  Harish Pant (Rockville, Maryland);  Niranjana D. Amin (Clarksburg, Maryland)
ABSTRACT Methods of decreasing cell viability of cancer cells, increasing apoptosis of cancer cells, and treating cancer in a mammal with cancer are provided. The methods include administering (i) a polypeptide comprising an amino acid sequence with at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 1, (ii) a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide, (iii) a vector comprising the nucleic acid molecule, (iv) a recombinant cell comprising any one of (i)-(iii), and/or (v) a composition comprising any one of (i)-(iv).
FILED Wednesday, November 13, 2019
APPL NO 17/294011
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/4745 (20130101)
A61K 38/00 (20130101)

Peptides
C07K 14/4703 (20130101) Original (OR) Class
C07K 14/4738 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/63 (20130101)
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US 20220009991 Antipov et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Silver Creek Pharmaceuticals, Inc. (San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) Laura D.J. Antipov (Oakland, California);  Shawdee Eshghi (Oakland, California);  Kristopher M. Kuchenbecker (Phoenix, Arizona);  Bjorn L. Millard (Orinda, California);  Matthew D. Onsum (El Cerrito, California);  Andrea D. Nickerson (San Francisco, California);  Timothy R. Stowe (San Francisco, California);  Yan Zhang (San Francisco, California)
ABSTRACT Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue.
FILED Tuesday, September 28, 2021
APPL NO 17/487120
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/47 (20130101)
C07K 14/65 (20130101) Original (OR) Class
C07K 14/765 (20130101)
C07K 2319/035 (20130101)
C07K 2319/75 (20130101)
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US 20220010019 Swirski et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Filip K. Swirski (Swampscott, Massachusetts);  Shun He (Malden, Massachusetts)
ABSTRACT Methods and compositions of treating patients with metabolic syndrome or a disease associated with metabolic syndrome using inhibitors that target natural intraepithelial lymphocytes.
FILED Tuesday, November 26, 2019
APPL NO 17/297153
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/26 (20130101)
A61K 2039/505 (20130101)

Peptides
C07K 16/2839 (20130101) Original (OR) Class
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US 20220010273 Gabrilovich
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Dmitry I. Gabrilovich (Villanova, Pennsylvania)
ABSTRACT Provided herein are methods of generating MDSCs ex vivo. The methods include culturing blood cells with lactoferrin.
FILED Tuesday, August 13, 2019
APPL NO 17/291808
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/15 (20130101)
A61K 38/40 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 37/06 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0634 (20130101) Original (OR) Class
C12N 2501/73 (20130101)
C12N 2501/2306 (20130101)
C12N 2506/11 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010279 QUACH et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) CORNELL UNIVERSITY (Ithaca, New York);  THE GEORGE WASHINGTON UNIVERSITY (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Bonnie QUACH (Ithaca, New York);  Trine KROGH-MADSEN (Ithaca, New York);  David J. CHRISTINI (Ithaca, New York);  Emilia ENTCHEVA (Washington, District of Columbia)
ABSTRACT The present disclosure is directed to kits and methods for performing optical dynamic clamping on an excitable cell. In some embodiments, the excitable cell is selected from the group consisting of a neuron, a muscle cell and an excitable cell derived from an induced Pluripotent Stem Cell (IPSC). In a specific embodiment, the muscle cell is a cardiomyocyte.
FILED Tuesday, October 01, 2019
APPL NO 17/282181
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0068 (20130101)
C12N 5/0657 (20130101) Original (OR) Class
C12N 5/0696 (20130101)
C12N 2506/45 (20130101)
C12N 2529/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010282 Karp et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
ASSIGNEE(S) THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts);  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts)
INVENTOR(S) Jeffrey Karp (Boston, Massachusetts);  Amit Choudhary (Boston, Massachusetts);  Kisuk Yang (Boston, Massachusetts);  Miseon Lee (Cambridge, Massachusetts);  Peter Jones (Cambridge, Massachusetts)
ABSTRACT 3D cell cultures and devices for 3D cell culture, and methods of use thereof are provided. In some embodiments, the 3D cell culture comprise pancreatic β cells and can be generated in multi-well plates, allowing for high throughput assays on the cell culture.
FILED Wednesday, June 16, 2021
APPL NO 17/349646
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 23/12 (20130101)
C12M 23/24 (20130101)
C12M 23/48 (20130101)
C12M 25/04 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0677 (20130101) Original (OR) Class
C12N 2513/00 (20130101)
C12N 2533/30 (20130101)
C12N 2533/52 (20130101)
C12N 2533/54 (20130101)
C12N 2533/90 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010284 Silpe et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S) The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S) The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S) Justin E. Silpe (Lawrenceville, New Jersey);  Bonnie L. Bassler (Princeton, New Jersey)
ABSTRACT Disclosed are recombinant phages that infect and kill bacterial hosts in response to user-defined inputs. The components that encode the user-defined inputs can be combined, such that multiple inputs are maintained on a single recombinant phage, enabling precise control over the targeting strategy. The phages can be engineered to kill a specific bacterial species or multiple species simultaneously. Recombinant phages can also be engineered to harbor fluorescent and bioluminescent reporter genes that enable them to be used for tracking, detection, and in biosensing applications. Recombinant phages can also be used to lyse bacterial cells that produce recombinant proteins, as a rapid method to enable extraction and high-level purification of potentially valuable and/or industrially important proteins. Also disclosed is a system that can also be used to control the activity of a protein of interest, by taking advantage of an interaction between Qtip and a phage repressor protein; a phage repressor protein can be fused to a protein-of-interest, and by controlling the expression of qtip, the phage repressor protein fused to a protein-of-interest will be inactivated when Qtip is expressed and interacts with the phage repressor protein.
FILED Thursday, October 31, 2019
APPL NO 17/289336
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101) Original (OR) Class
C12N 15/73 (20130101)
C12N 15/74 (20130101)
C12N 2795/10121 (20130101)
C12N 2795/10122 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010285 LIU
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) BioVentures, LLC (Little Rock, Arkansas)
ASSIGNEE(S) BioVentures, LLC (Little Rock, Arkansas)
INVENTOR(S) Jia LIU (Little Rock, Arkansas)
ABSTRACT The present disclosure provides compositions and methods for increasing the production of virus in vitro. Modified cells which are modified to eliminate or reduce as compared to a control cell the activity or expression of a Sterile a motif-domain containing protein 9 (SAMD9) polypeptide are provided. Methods of using these cells are also provided.
FILED Wednesday, November 20, 2019
APPL NO 17/295761
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101) Original (OR) Class
C12N 9/22 (20130101)
C12N 15/111 (20130101)
C12N 2710/24052 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010299 Das et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) Rhiju Das (Palo Alto, California);  Christian A. Choe (Stanford, California);  Hannah K. Wayment-Steele (Stanford, California);  Wipapat Kladwang (Stanford, California)
ABSTRACT Embodiments herein describe systems and methods to enhance RNA translation and stability and uses thereof. Many embodiments generate RNA molecules possessing increased structure and/or reduced free energy over an initial sequence. Such RNA molecules can be used as therapeutics and/or vaccines.
FILED Thursday, July 01, 2021
APPL NO 17/364890
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7115 (20130101)

Peptides
C07K 14/005 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/102 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010300 Wyss-Coray et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Anton Wyss-Coray (Palo Alto, None);  Carolyn R. Bertozzi (Menlo Park, California);  Julia Marschallinger (Palo Alto, California);  Michael S. Haney (Mountain View, California)
ABSTRACT Methods of treating a subject for a neurodegenerative disorder are provided. Aspects of the methods include administering to a subject in need thereof an effective amount of an agent that reduces the prevalence of lipid droplet accumulating microglia (LAM) to treat the subject for the neurodegenerative disorder. A variety of neurodegenerative disorders may be treated by practice of the methods. Also provided are methods of identifying lipid droplet-associated target genes, including target genes that are positive and negative regulators of lipid droplet formation, as well as methods of treating a neurodegenerative disorder in a subject by administering to the subject an antagonist of a positive regulator of lipid droplet formation and/or an agonist of a negative regulator of lipid droplet formation.
FILED Thursday, January 09, 2020
APPL NO 17/413360
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/1709 (20130101)

Peptides
C07K 16/18 (20130101)
C07K 2317/76 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)
C12N 15/1037 (20130101) Original (OR) Class
C12N 2310/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010302 Mirkin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Chad A. Mirkin (Wilmette, Illinois);  Gokay Yamankurt (Chicago, Illinois);  Milan Mrksich (Hinsdale, Illinois);  Eric J. Berns (Park Ridge, Illinois);  Neda Bagheri (Chicago, Illinois);  Albert Xue (Chicago, Illinois);  Andrew Lee (Evanston, Illinois)
ABSTRACT The present disclosure provides methods for the rapid synthesis of large libraries of spherical nucleid acid (SNA) nanoparticles, their screening for activity, and a machine learning algorithm to analyze the data.
FILED Friday, April 12, 2019
APPL NO 17/046482
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1086 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010307 Mischel et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Human Genome Research Institute (NHGRI)
National Institute of General Medical Sciences (NIGMS)
NIH Office of the Director (NIHOD)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) The Regents of the University of California (Oakland, California);  Ludwig Institute for Cancer Research Ltd (La Jolla, California);  The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Paul Mischel (La Jolla, California);  Bing Ren (La Jolla, California);  Kristen Turner (La Jolla, California);  Sihan Wu (La Jolla, California);  Vineet Bafna (Oakland, California);  Nam-phuong Nguyen (Oakland, California);  Howard Chang (Stanford, California)
ABSTRACT Provided herein are, inter alia, methods and compositions to detect, monitor and treat cancer, wherein the cancer includes amplified extrachromosomal oncogenes. The methods are useful for personalized treatment and exploit differential expression and chromatin structure of extrachromosomal oncogenes in cancer cells.
FILED Tuesday, December 10, 2019
APPL NO 17/311980
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7105 (20130101)
A61K 45/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/111 (20130101) Original (OR) Class
C12N 15/113 (20130101)
C12N 2310/11 (20130101)
C12N 2310/20 (20170501)
C12N 2320/31 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010309 Khvorova et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Anastasia Khvorova (Westborough, Massachusetts);  Loïc Maurice René Jean Roux (Worcester, Massachusetts);  Ken Yamada (Boston, Massachusetts)
ABSTRACT This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.
FILED Friday, March 26, 2021
APPL NO 17/213852
CURRENT CPC
Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 19/067 (20130101)
C07H 21/02 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/314 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010310 Feinberg et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Mark W. Feinberg (Newton, Massachusetts);  Stefan Haemmig (Brookline, Massachusetts)
ABSTRACT Methods and compositions for use in treating subjects suffering from a disease associated with a malfunction in DNA repair response using compositions that comprise or encode SNHG12 long non-coding RNA.
FILED Tuesday, November 12, 2019
APPL NO 17/291922
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/317 (20130101)
C12N 2310/321 (20130101)
C12N 2310/3521 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010312 Mueller et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S) University of Massachusetts (Boston, Massachusetts)
INVENTOR(S) Christian Mueller (Concord, Massachusetts);  Neil Aronin (Newtonville, Massachusetts);  Edith L. Pfister (Boxborough, Massachusetts)
ABSTRACT Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and methods of treating Huntington's disease using the same.
FILED Friday, May 21, 2021
APPL NO 17/326400
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 15/86 (20130101)
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/141 (20130101)
C12N 2310/3519 (20130101)
C12N 2330/51 (20130101)
C12N 2750/14121 (20130101)
C12N 2750/14141 (20130101)
C12N 2750/14143 (20130101)
C12N 2750/14171 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010313 Friedland et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) EDITAS MEDICINE, INC. (Cambridge, Massachusetts)
ASSIGNEE(S) EDITAS MEDICINE, INC. (Cambridge, Massachusetts)
INVENTOR(S) Ari E. Friedland (Boston, Massachusetts);  Penrose O'Donnell (Yarmouth, Maine);  David A. Bumcrot (Belmont, Massachusetts)
ABSTRACT CRISPR/CAS-related systems, compositions and methods for editing RS1, RL2, and/or LAT genes in human cells are described, as are cells and compositions including cells edited according to the same.
FILED Monday, April 19, 2021
APPL NO 17/234145
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/102 (20130101)
C12N 15/1133 (20130101) Original (OR) Class
C12N 2310/10 (20130101)
C12N 2310/20 (20170501)
C12N 2800/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010317 BORDENSTEIN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Organismal Systems (IOS)
APPLICANT(S) VANDERBILT UNIVERSITY (Nashville, Tennessee);  lNSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNI (Paris, France);  THE UNIVERSITY OF CHICAGO (Chicago, Israel)
ASSIGNEE(S)
INVENTOR(S) Sarah BORDENSTEIN (Nashville, Tennessee);  Julie REVEILLAUD (Montpellier, France);  A. Murat EREN (Chicago, Illinois);  Seth BORDENSTEIN (Nashville, Tennessee)
ABSTRACT The present disclosure relates to plasmids, systems, and methods for the transformation of Wolbachia. Disclosed herein are plasmids and systems for use in methods of transforming Wolbachia. The inventors have identified extrachromosomal plasmids within Wolbachia. Disclosed herein is a non-naturally occurring plasmid comprising a nucleic acid encoding a transposase. Disclosed herein is a method for transforming a Wolbachia cell, comprising introducing a non-naturally occurring plasmid into the cell, wherein the plasmid comprises a nucleic acid sequence capable of transforming a Wolbachia cell.
FILED Friday, November 15, 2019
APPL NO 17/293634
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/74 (20130101) Original (OR) Class
C12N 2800/101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010331 Thomson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Research Resources (NCRR)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Wisconsin Alumni Resarch Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) James Thomson (Madison, Wisconsin);  Junying Yu (Middleton, Wisconsin)
ABSTRACT Methods for reprogramming primate somatic cells to pluripotency using an episomal vector that does not encode an infectious virus are disclosed. Pluripotent cells produced in the methods are also disclosed.
FILED Monday, June 21, 2021
APPL NO 17/352873
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0696 (20130101)
C12N 15/85 (20130101) Original (OR) Class
C12N 2501/602 (20130101)
C12N 2501/603 (20130101)
C12N 2501/604 (20130101)
C12N 2501/605 (20130101)
C12N 2501/606 (20130101)
C12N 2501/608 (20130101)
C12N 2510/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010333 Mali et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Human Genome Research Institute (NHGRI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Prashant Mali (La Jolla, California);  Dhruva Katrekar (La Jolla, California);  Dario Meluzzi (La Jolla, California);  Genghao Chen (La Jolla, California);  Kyle M. Ford (La Jolla, California)
ABSTRACT Disclosed herein is a system to recruit ADARs to catalyze therapeutic editing of point mutations via the use of engineered RNA scaffolds, engineered DNA scaffolds or DNA-RNA hybrid scaffolds. The system comprises an engineered ADAR2 guide RNA (adRNA) that bears a 20-100 bp complementarity with the target RNA and ADAR2 recruiting domain from the GluR2 mRNA at either or both the 5′ end or the 3′ end.
FILED Friday, September 06, 2019
APPL NO 17/273885
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7088 (20130101)
A61K 48/0066 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/00 (20180101)
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101) Original (OR) Class
C12N 15/111 (20130101)
C12N 15/113 (20130101)
C12N 2310/11 (20130101)
C12N 2310/16 (20130101)
C12N 2310/531 (20130101)
C12N 2320/31 (20130101)
C12N 2320/32 (20130101)
C12N 2320/33 (20130101)
C12N 2320/35 (20130101)
C12N 2750/14343 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010335 RAO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Catholic University of America (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Venigalla B. RAO (Silver Spring, Maryland);  Jingen ZHU (Washington, District of Columbia)
ABSTRACT Described is hybrid viral vector comprising: a first virus such as bacteriophage T4; one or more second virus such as adeno-associated virus (AAV) attached to the first virus through cross-bridges, such as avidin-biotin cross-bridges; one or more DNA molecules packaged in the first virus; one or more nucleic acid molecules packaged in the second virus; and one or more proteins displayed on the surface of the first virus. Also described are methods of making and using such a hybrid viral vector.
FILED Wednesday, September 29, 2021
APPL NO 17/488542
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101) Original (OR) Class
C12N 2750/14133 (20130101)
C12N 2750/14134 (20130101)
C12N 2795/10133 (20130101)
C12N 2795/10134 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010338 Doudna et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Emmanuelle Charpentier (Berlin, Germany);  The Regents of the University of California (Oakland, California);  University of Vienna (Vienna, Austria)
ASSIGNEE(S)
INVENTOR(S) Jennifer A. Doudna (Berkeley, California);  Martin Jinek (Berkeley, California);  Krzysztof Chylinski (Vienna, Austria);  Emmanuelle Charpentier (Berlin, Germany)
ABSTRACT The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
FILED Tuesday, September 21, 2021
APPL NO 17/481063
CURRENT CPC
New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques
A01H 6/4684 (20180501)

Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/027 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 38/465 (20130101)
A61K 48/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/63 (20130101)
C12N 15/70 (20130101)
C12N 15/90 (20130101)
C12N 15/102 (20130101)
C12N 15/111 (20130101)
C12N 15/113 (20130101)
C12N 15/746 (20130101)
C12N 15/902 (20130101)
C12N 15/907 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2310/13 (20130101)
C12N 2310/20 (20170501)
C12N 2310/531 (20130101)
C12N 2310/3519 (20130101)
C12N 2800/80 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101)

Enzymes
C12Y 301/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010339 ZHANG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Feng ZHANG (Cambridge, Massachusetts);  Omar O. ABUDAYYEH (Cambridge, Massachusetts);  James E. DAHLMAN (Cambridge, Massachusetts);  Patrick HSU (Cambridge, Massachusetts);  David A. SCOTT (Cambridge, Massachusetts)
ABSTRACT The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems, wherein the guide sequence is modified by secondary structure to increase the specificity of the CRISPR-Cas system and whereby the secondary structure can protect against exonuclease activity and allow for 5′ additions to the guide sequence.
FILED Wednesday, September 29, 2021
APPL NO 17/489308
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0275 (20130101)
A01K 2217/07 (20130101)
A01K 2227/105 (20130101)

Peptides
C07K 14/4702 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 9/96 (20130101)
C12N 15/11 (20130101)
C12N 15/111 (20130101)
C12N 15/907 (20130101) Original (OR) Class
C12N 2310/20 (20170501)

Enzymes
C12Y 301/21004 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010365 Wolff et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The Government of the USA as represented by the Secretary of the Dept. of Health and Human Services (Atlanta, Georgia)
ASSIGNEE(S) The Government of the USA as represented by the Secretary of the Dept. of Health and Human Services (Atlanta, Georgia)
INVENTOR(S) Bernard J. Wolff (Roswell, Georgia);  Jonas M. Winchell (Lilburn, Georgia);  Maureen Diaz (Atlanta, Georgia)
ABSTRACT Methods for detecting presence of one or more of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumooniae, Toxoplasma gondii, Moraxella catarrhalis, Escherichia coli, Shigella, Staphylococcus aureus, Pneumocystis jirovecii, Chlamydia trachomatis, Ureaplasma urealyticum, Ureaplasma parvum, Ureaplasma spp., Bartonella spp., Streptococcus agalactiae, and Neisseria meningitidis nucleic acids in a sample, such as a biological sample obtained from a subject, or an environmental sample, are provided. This disclosure also provides probes, primers, and kits for detecting one or more of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Toxoplasma gondii, Moraxella catarrhalis, Escherichia coli, Shigella, Staphylococcus aureus, Pneumocystis jirovecii, Chlamydia trachomatis, Ureaplasma urealyticum, Ureaplasma parvum, Ureaplasma spp., Bartonella spp., Streptococcus agalactiae, and Neisseria meningitidis in a sample.
FILED Monday, September 27, 2021
APPL NO 17/485953
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101) Original (OR) Class
C12Q 1/6895 (20130101)
C12Q 2600/16 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010376 SALK et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute on Aging (NIA)
APPLICANT(S) UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (SEATTLE, Washington)
ASSIGNEE(S)
INVENTOR(S) Jesse SALK (Seattle, Washington);  Lawrence A. LOEB (Bellevue, Washington);  Michael SCHMITT (Seattle, Washington)
ABSTRACT Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands.
FILED Monday, September 27, 2021
APPL NO 17/448973
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6806 (20130101)
C12Q 1/6869 (20130101)
C12Q 1/6876 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010380 Hoyo et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute of Environmental Health Sciences (NIEHS)
National Institute on Minority Health and Health Disparities (NIMHD)
APPLICANT(S) North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S) North Carolina State University (Raleigh, North Carolina)
INVENTOR(S) Cathrine Hoyo (Raleigh, North Carolina);  David Skaar (Raleigh, North Carolina);  Dereje Jima (Raleigh, North Carolina);  Randy L. Jirtle (Raleigh, North Carolina)
ABSTRACT Provided are compositions and methods for determining an imprinting status of a gene subject to parent-of-origin, monoalleleic expression in a subject, and for using the information derived therefrom to detect a presence of and/or a susceptibility to a medical condition associated with monoallelic expression in a subject, predict a susceptibility to future development of a medical condition prior to the onset of any symptoms, monitor the development of such a medical condition and/or the effectiveness of a treatment, and for treating such a medical condition. In some embodiments, a composition for use in the disclosed methods is nucleic acid array, which in some embodiments can include one or more interrogatable nucleotide molecules, wherein the interrogatable nucleotide molecules are designed to allow identification of the DNA methylation status of one or more imprint control regions (ICRs) that regulate one or more genes subject to monoalleleic expression in subjects.
FILED Friday, July 09, 2021
APPL NO 17/372113
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101) Original (OR) Class
C12Q 2600/154 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011216 Lo et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Yu-Hwa Lo (San Diego, California);  Yuanyuan Han (San Diego, California);  Yi Gu (San Diego, California);  Ce Zhang (La Jolla, California)
ABSTRACT Disclosed are systems, devices and methods for imaging and image-based sorting of particles in a flow system, including cells in a flow cytometer. In some aspects, a system includes a particle flow device to flow particles through a channel, an imaging system to obtain image data of a particle during flow through the channel, a processing unit to determine a property associated with the particle and to produce a control command for sorting the particle based on sorting criteria associated with particle properties, and an actuator to direct the particle into one of a plurality of output paths of the particle flow device in real-time.
FILED Thursday, May 20, 2021
APPL NO 17/326312
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 3/36 (20130101)
G01J 3/46 (20130101)
G01J 3/51 (20130101)
G01J 3/0208 (20130101)
G01J 3/0229 (20130101)
G01J 3/4406 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/147 (20130101)
G01N 15/1429 (20130101)
G01N 15/1475 (20130101) Original (OR) Class
G01N 15/1484 (20130101)
G01N 2015/1006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011270 Arvanitis et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Costas Arvanitis (Atlanta, Georgia);  Arpit Patel (Atlanta, Georgia);  Scott Joseph Schoen, Jr. (Atlanta, Georgia);  Zhigen Zhao (Atlanta, Georgia)
ABSTRACT This disclosure describes systems and methods for ultrasound imaging and targeting. In one example, the systems and methods improve targeting and imaging through a heterogenous medium by using the angular spectrum approach (ASA) alone or in combination with passive acoustic mapping (PAM). In another example, the systems and methods improve the ultrasound imaging of vessels using microbubbles. The imaging of the vessels is also aided by the ASA and PAM. A closed loop controller is described that adjusts the ultrasound pressure provided to a region of interest to a desired pressure based at least in part on the harmonic, ultra-harmonic, sub-harmonic, or broadband frequency ranges for the microbubbles.
FILED Thursday, November 07, 2019
APPL NO 17/291504
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 29/221 (20130101)
G01N 29/348 (20130101)
G01N 29/0654 (20130101) Original (OR) Class
G01N 2291/102 (20130101)
G01N 2291/02475 (20130101)
G01N 2291/02483 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011296 Ligon et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Keith Ligon (Brookline, Massachusetts);  Seth William Malinowski (Boston, Massachusetts);  Scott R. Manalis (Cambridge, Massachusetts);  Selim Olcum (Cambridge, Massachusetts);  Robert J. Kimmerling (Cambridge, Massachusetts);  Nicholas L. Calistri (New Fairfield, Connecticut);  David Weinstock (Jamaica Plain, Massachusetts);  Mark Murakami (Cambridge, Massachusetts);  Mark M. Stevens (Seattle, Washington)
ABSTRACT Aspects of the application relate to methods and systems for evaluating treatment response by measuring treatment-induced changes at the single cell level. The disclosure provides methods for isolating single cells that are primary cancer cells, including primary cancer cells from solid tumors, and detecting in minutes to hours from their removal from the body the response of such cells to anti-cancer agents such as radiation, small molecules, biologies, DNA damaging agents and the like.
FILED Thursday, November 14, 2019
APPL NO 17/293890
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5017 (20130101) Original (OR) Class
G01N 33/5085 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011304 Hu et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) UNIVERSITY OF NOTRE DAME DU LAC (Notre Dame, Indiana)
ASSIGNEE(S)
INVENTOR(S) Jiayun Hu (Notre Dame, Indiana);  Paul W. Bohn (Notre Dame, Indiana);  Marvin J. Miller (South Bend, Indiana);  Manuka Ghosh (Granger, Indiana)
ABSTRACT Described is a biosensor for detection of analytes and methods of using the same for detecting bacterial infection in a subject. The biosensor comprises an array of gold nanoparticles, biotinylated polyethylene glycol thiol, polyethylene glycol thiol, at least one neutravidin molecule, and at least one affinity reagent immobilized on a surface of the at least one neutravidin molecule. The affinity reagent may be an aptamer or a siderophore. The biosensors demonstrate extraordinary selectively and sensitivity for rapid detection of whole-cell bacteria.
FILED Thursday, December 20, 2018
APPL NO 17/297385
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/115 (20130101)
C12N 2310/16 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/658 (20130101)
G01N 33/54373 (20130101) Original (OR) Class
G01N 33/56911 (20130101)
G01N 2333/21 (20130101)
G01N 2333/22 (20130101)
G01N 2800/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011325 Krishnan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Yamuna Krishnan (Chicago, Illinois);  Kasturi Chakraborty (Chicago, Illinois);  Ka Ho Leung (Chicago, Illinois);  Anand Saminathan (Chicago, Illinois)
ABSTRACT This disclosure relates to methods for determining pH and also calcium (Ca2+) concentration or chloride (Cl) concentration in biological samples. More particularly, this disclosure relates to methods capable of simultaneously determining pH and Ca2+ concentration, or pH and Cl concentration using nucleic acid complexes.
FILED Monday, December 02, 2019
APPL NO 17/295704
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6825 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/84 (20130101) Original (OR) Class
G01N 33/582 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011386 Knappe et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Yoshio OKADA (Denver, Colorado);  The Regents of the University of Colorado, a body corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Svenja Knappe (Boulder, Colorado);  Yoshio Okada (Brookline, Massachusetts);  Sean Krzyzewski (Boulder, Colorado)
ABSTRACT Various embodiments of the present technology relate generally to the field of imaging the spatial distribution of magnetic field of biologic and non-biologic materials that may change over time and more particularly to the apparatus and methods for making such a static or dynamic spatial imaging of magnetic field distributions. Some embodiments provide for apparatus and methods for a novel magnetographic camera which enables a unique ability to determine the spatial distribution of magnetic field in a biological or non-biological sample with high spatial and temporal resolutions and high sensitivity. The use of these embodiments will greatly expand the applications of OPM-based cameras in medicine, science and industry.
FILED Thursday, November 21, 2019
APPL NO 17/296179
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/26 (20130101) Original (OR) Class
G01R 33/246 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012875 Arnaout
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Rima Arnaout (San Francisco, California)
ABSTRACT Systems and methods for medical image diagnoses in accordance with embodiments of the invention are illustrated. One embodiment includes a method for evaluating multimedia content. The method includes steps for receiving multimedia content and identifying a set of one or more image frames for each of several target views from the received multimedia content. For each target view, the method includes steps for evaluating the corresponding set of image frames to generate an intermediate result. The method includes steps for determining a composite result based on the intermediate results for each of the several target views.
FILED Wednesday, September 18, 2019
APPL NO 17/281883
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/628 (20130101)
G06K 9/6262 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101) Original (OR) Class
G06T 7/13 (20170101)
G06T 2207/10016 (20130101)
G06T 2207/20132 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012902 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
National Eye Institute (NEI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Jacob Antunes (Cincinnati, Ohio);  Zhouping Wei (Cleveland, Ohio);  Pallavi Tiwari (Wexford, Pennsylvania);  Satish E. Viswanath (Pepper Pike, Ohio);  Charlems Alvarez Jimenez (Bogotá, Colombia)
ABSTRACT The present disclosure, in some embodiments, relates to a non-transitory computer-readable medium storing computer-executable instructions. The computer readable medium is configured to cause a processor to access an image volume of a rectum comprising a rectal tumor. A forward mapping is generated based on non-rigidly registering a healthy rectal atlas to the image volume. The forward mapping is inverted to generate an inverse mapping from the image volume to the healthy rectal atlas. Based on the inverse mapping, a plurality of deformation vectors, associated with a deformation within a rectal wall of the rectum, are determined. Magnitude based deformation features and orientation based deformation features are computed from the plurality of deformation vectors. One or more of the magnitude based deformation features and one or more of the orientation based deformation features are utilized to determine a response of a patient to a chemoradiation treatment.
FILED Wednesday, September 22, 2021
APPL NO 17/481625
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/33 (20170101) Original (OR) Class
G06T 7/38 (20170101)
G06T 2207/10088 (20130101)
G06T 2207/30096 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/40 (20180101)
G16H 50/70 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 20220007819 O'Brien
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Secretary of the Air Force (SECAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S) Justin O'Brien (Huber Heights, Ohio)
ABSTRACT Personal hydration systems with cooling and/or warming capability, and the components thereof are disclosed. The personal hydration systems may include a liquid transport system for transporting cooling or heating fluid between a reservoir and a pad, which pad is configured for wearing adjacent to a wearer's body. A pump is provided for pumping the liquid through the system. A drinking tube is connected to the system for removing liquid from the system. Liquid can be removed from the system for drinking by sucking on the end of the drinking tube. A check valve is used to bypass the pump so the user will not have to suck the liquid through the pump. Alternatively, liquid can be removed by spraying the liquid out of the drinking tube using the power of the pump.
FILED Friday, April 16, 2021
APPL NO 17/232183
CURRENT CPC
Travelling or Camp Equipment: Sacks or Packs Carried on the Body
A45F 3/20 (20130101) Original (OR) Class
A45F 2003/166 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008001 Argenta et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
Army Medical Research Acquisition Activity (USAMRAA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Applied Research Associates, Inc. (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Christopher Argenta (Albuquerque, New Mexico);  Aaron Williams (Albuquerque, New Mexico);  Greg Foderaro (Albuquerque, New Mexico);  Thomas Paniagua (Albuquerque, New Mexico)
ABSTRACT A system and method of generating an enhanced Lund and Browder chart and total body surface area burn score is described herein. In some embodiments, a plurality of images is obtained from of a patient using a camera system. The images may be taken by aligning the patient's body with pose templates presented on a display of the camera system. The non-skin portions of the images may be removed, and skin analysis performed on the skin portion to determine burn location, coverage, and depth. Further, landmarks may be detected in the images to morph and align the images with the pose templates to obtain standard poses. The plurality of images may be combined and presented in two-dimensional and three-dimensional models with labels and the total surface area burn score.
FILED Tuesday, July 07, 2020
APPL NO 16/922598
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0013 (20130101)
A61B 5/0075 (20130101)
A61B 5/0077 (20130101)
A61B 5/445 (20130101) Original (OR) Class
A61B 5/743 (20130101)
A61B 5/744 (20130101)
A61B 5/6898 (20130101)
A61B 5/7264 (20130101)
A61B 5/7282 (20130101)
A61B 2576/02 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/52 (20130101)
G06K 9/00671 (20130101)
G06K 9/2018 (20130101)
G06K 9/4604 (20130101)
G06K 2209/05 (20130101)

Image Data Processing or Generation, in General
G06T 11/206 (20130101)
G06T 19/20 (20130101)
G06T 2219/2016 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 50/20 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008346 Wilson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Congressionally Directed Medical Research Programs (CDMRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) John T. Wilson (Nashville, Tennessee);  Daniel Shae (Nashville, Tennessee);  Dinh Chuong Nguyen (Phu Nhuan District, Ho Chi Minh, Viet Nam)
ABSTRACT A graft copolymer and a method of delivering an active agent to a subject are provided. The graft copolymer includes a polymer backbone, a hydrophilic segment grafted to the polymer backbone, a pH-responsive segment grafted to the polymer backbone, and an endosomal disruption segment grafted to the polymer backbone. The method of delivering an active agent to a subject includes encapsulating the active agent with the graft copolymer and administering the encapsulated active agent to the subject.
FILED Wednesday, October 30, 2019
APPL NO 17/290618
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5026 (20130101) Original (OR) Class

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 290/062 (20130101)
C08F 2438/03 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008383 Yee et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Amy Yee (Brookline, Massachusetts);  Eric Paulson (Brookline, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Amy Yee (Brookline, Massachusetts);  Eric Paulson (Brookline, Massachusetts)
ABSTRACT The present invention relates to compositions and methods of treating a subject having cancer by stimulating the subject's immune system and/or enhancing immunotherapies. Specifically, the present invention relates to methods of treating a subject by administering (1) a catechin ester or a derivative or metabolite thereof (e.g., EGCG) and (2) a nucleoside analogue (e.g., DAC), in combination with a checkpoint inhibitor or T-cell therapy.
FILED Wednesday, November 13, 2019
APPL NO 17/293648
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/353 (20130101) Original (OR) Class
A61K 31/7068 (20130101)

Peptides
C07K 16/2818 (20130101)
C07K 16/2827 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008918 ISMAGILOV et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Rustem F. ISMAGILOV (Altadena, California);  Travis S. SCHLAPPI (Pasadena, California);  Stephanie E. MCCALLA (Bozeman, Montana);  Nathan G. SCHOEPP (Pasadena, California)
ABSTRACT Methods and devices for detecting a low concentration analyte in a sample are provided herein. The methods include flowing a sample through a porous membrane coated with a capture matrix to capture the low concentration analyte. The methods also can include detecting the captured analyte, such as by performing in-situ amplification of the analyte.
FILED Friday, July 07, 2017
APPL NO 16/316193
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/5023 (20130101)
B01L 3/502715 (20130101) Original (OR) Class
B01L 7/52 (20130101)
B01L 2300/069 (20130101)
B01L 2300/163 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009199 Smith et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
United States Air Force (USAF)
APPLICANT(S) SWIFT TEXTILE METALIZING LLC (Bloomfield, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Alexander T. Smith (Knoxville, Tennessee);  Jared DG Butlin (Longmeadow, Massachusetts)
ABSTRACT A composite structure is provided that includes a polymer layer and an auxetic material layer disposed within or partially within the polymer layer. The auxetic material layer provides increased conductivity and elastomeric reinforcement to the polymer layer.
FILED Wednesday, June 16, 2021
APPL NO 17/349762
CURRENT CPC
Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 5/026 (20130101)
B32B 7/12 (20130101)
B32B 7/022 (20190101) Original (OR) Class
B32B 7/025 (20190101)
B32B 27/12 (20130101)
B32B 27/20 (20130101)
B32B 2255/02 (20130101)
B32B 2255/26 (20130101)
B32B 2262/02 (20130101)
B32B 2307/202 (20130101)
B32B 2307/212 (20130101)
B32B 2307/706 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009300 Benedict et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) The Texas A and M University System (College Station, Texas)
ASSIGNEE(S) The Texas A and M University System (College Station, Texas)
INVENTOR(S) Moble Benedict (College Station, Texas);  Sean M. McHugh (San Jose, California);  Chase B. Wiley (Keller, Texas);  Ramsay A. Ramsey (College Station, Texas);  Adam Kellen (San Antonio, Texas);  Yin Lu Young (Ann Arbor, Michigan)
ABSTRACT An amphibious vehicle for traversing land and bodies of water includes a chassis, and a cycloidal propeller coupled to the chassis and which includes a plurality of cycloidal propeller blades rotatably coupled to the chassis and each extending parallel a rotational axis of the cycloidal propeller, and an extension/retraction system configured to extend the plurality of cycloidal propeller blades away from the chassis and to retract the plurality of cycloidal propeller blades towards the chassis.
FILED Friday, May 14, 2021
APPL NO 17/321048
CURRENT CPC
Vehicles for Use Both on Rail and on Road; Amphibious or Like Vehicles; Convertible Vehicles
B60F 3/0007 (20130101) Original (OR) Class

Marine Propulsion or Steering
B63H 1/06 (20130101)
B63H 3/00 (20130101)
B63H 21/17 (20130101)
B63H 25/42 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009532 Notomista et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Gennaro Notomista (Atlanta, Georgia);  Magnus B. Egerstedt (Atlanta, Georgia);  Yousef A. Emam (Atlanta, Georgia)
ABSTRACT An exemplary embodiment of the present disclosure provides a robot comprising a body, a processor, and a memory. The memory further comprising instructions that, when executed by the processor cause the body to engage a first wire to support the robot from the first wire, traverse the first wire, engage a second wire simultaneously while engaging the first wire, the second wire branching from the first wire, then after engaging the second wire, disengage the first wire and traverse the second wire.
FILED Tuesday, February 16, 2021
APPL NO 17/176927
CURRENT CPC
Railway Systems; Equipment Therefor Not Otherwise Provided for
B61B 3/02 (20130101)

Guiding Railway Traffic; Ensuring the Safety of Railway Traffic
B61L 3/006 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009651 Lampazzi et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Lockheed Martin Corporation (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S) Margaret MacIsaac Lampazzi (Newtown, Connecticut);  Carl John Pankok, JR. (Philadelphia, Pennsylvania);  Igor Cherepinsky (Sandy Hook, Connecticut)
ABSTRACT A technique relates to interactive aircraft operation. An interactive electronic checklist is selected from a plurality of interactive electronic checklists, the interactive electronic checklists each comprising checklist tasks. It is perceived that one or more of the checklist tasks in the interactive electronic checklist is executable by an autonomous system. The one or more of the checklist tasks is performed using the autonomous system, an operator being designated to perform any other ones of the checklist tasks.
FILED Wednesday, July 08, 2020
APPL NO 16/923143
CURRENT CPC
Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for
B64F 5/60 (20170101) Original (OR) Class

Electric Digital Data Processing
G06F 3/0482 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010055 Nuckolls et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
INVENTOR(S) Colin Nuckolls (New York, New York);  Xavier Roy (New York, New York);  Jake Carter Russell (New York, New York);  Samuel R. Peurifoy (New York, New York)
ABSTRACT The present disclosure provides organic compounds having pseudocapacitive performance and methods of preparing said compounds. The organic compounds can include perylene diamine (PDI) subunits and hexaazatrinaphthylene (HATN) subunits.
FILED Friday, February 19, 2021
APPL NO 17/180046
CURRENT CPC
Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 61/122 (20130101) Original (OR) Class
C08G 2261/12 (20130101)
C08G 2261/228 (20130101)
C08G 2261/411 (20130101)
C08G 2261/3241 (20130101)

Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 11/48 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010165 Lukus et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) PPG Industries Ohio, Inc. (Cleveland, Ohio)
ASSIGNEE(S) PPG Industries Ohio, Inc. (Cleveland, Ohio)
INVENTOR(S) Peter Alan Lukus (Sarver, Pennsylvania);  Michael J. Pawlik (Glenshaw, Pennsylvania);  Silvia Bezer (Gibsonia, Pennsylvania);  Steven R. Zawacky (Cranberry Township, Pennsylvania);  Diane Jean Schillinger (Allison Park, Pennsylvania);  Samuel Logan Esarey (Allison Park, Pennsylvania)
ABSTRACT The present invention is directed to an aqueous curable film-forming composition comprising: (a) a film-forming component comprising an aliphatic di- or higher functional polyisocyanate; and (b) a catalyst additive comprising: (i) a catalytic organic compound comprising iron (II) and optionally tin; and (ii) a beta-diketone. The present invention is further directed to a method of controlling the rate of cure of an aqueous curable film-forming composition. The method comprises adding to the aqueous curable film-forming composition the catalyst additive described above; the aqueous curable film-forming composition comprises a film-forming component comprising an aliphatic di- or higher functional polyisocyanate. The present invention is additionally directed to a coated article comprising a cured coating layer applied on at least one surface of a substrate to form a coated substrate; wherein the cured coating layer is deposited from the aqueous curable film-forming composition described above.
FILED Thursday, November 08, 2018
APPL NO 17/292413
CURRENT CPC
Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 18/222 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 5/002 (20130101)
C09D 7/20 (20180101)
C09D 175/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010228 Collett et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Air Systems Command (NAVAIR)
United States Navy (USN)
APPLICANT(S) METSS Corp. (Westerville, Ohio)
ASSIGNEE(S) METSS Corp. (Westerville, Ohio)
INVENTOR(S) Brian R. Collett (Columbus, Ohio);  Angela Theys (Kansas City, Missouri);  Michelle Docter (Columbus, Ohio);  Joseph Sanders (Powell, Ohio);  Kenneth J. Heater (Delaware, Ohio)
ABSTRACT Lubricating compositions are described, the lubricating compositions comprising a base oil component and an additive component, wherein the additive component comprises a non-silicone anti-foaming agent.
FILED Tuesday, July 06, 2021
APPL NO 17/367964
CURRENT CPC
Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition
C10M 101/00 (20130101)
C10M 107/10 (20130101)
C10M 129/34 (20130101)
C10M 133/12 (20130101)
C10M 133/44 (20130101)
C10M 137/04 (20130101)
C10M 145/14 (20130101) Original (OR) Class
C10M 169/044 (20130101)
C10M 2205/0285 (20130101)
C10M 2207/123 (20130101)
C10M 2209/084 (20130101)
C10M 2215/06 (20130101)
C10M 2215/223 (20130101)
C10M 2223/041 (20130101)

Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions
C10N 2020/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010269 Cullen et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Veterans Affairs (DVA)
APPLICANT(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania);  The United States of America as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Daniel Kacy Cullen (Media, Pennsylvania);  Suradip Das (Philadelphia, Pennsylvania);  Wisberty Gordian-Velez (Philadelphia, Pennsylvania)
ABSTRACT In various aspects and embodiments, the present invention provides methods for preparing innervated tissue. In various embodiments the invention further provides innervated tissue generated using the methods described herein. In various embodiments the inclusion of optogenetically transducible TENGs or Micro-TENNs in the innervated tissue allows the modulation of tissue or organs by using light to stimulate the optogenetically transducible TENGs or Micro-TENNs.
FILED Friday, November 08, 2019
APPL NO 17/291869
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/34 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0068 (20130101) Original (OR) Class
C12N 5/0619 (20130101)
C12N 5/0633 (20130101)
C12N 5/0648 (20130101)
C12N 5/0657 (20130101)
C12N 5/0658 (20130101)
C12N 5/0677 (20130101)
C12N 5/0679 (20130101)
C12N 5/0685 (20130101)
C12N 2502/081 (20130101)
C12N 2513/00 (20130101)
C12N 2533/76 (20130101)
C12N 2533/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010391 Lloyd et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Office (CCDC ARO)
APPLICANT(S) U.S. Army Combat Capabilities Development Command, Army Research Labortary (Adelphi, Maryland)
ASSIGNEE(S)
INVENTOR(S) Jeffrey T. Lloyd (Aberdeen, Maryland);  Phillip A. Jannotti (Baltimore, Maryland);  Daniel J. Magagnosc (Baltimore, Maryland)
ABSTRACT A metal structure includes an alloy material containing structural deformation twins embedded during a manufacturing process of the alloy material along defined directions, a defined deformation sequence, and defined strain levels. The embedded structural deformation twins mitigate failure and fracture in the alloy material.
FILED Friday, July 10, 2020
APPL NO 16/925697
CURRENT CPC
Modifying the Physical Structure of Ferrous Metals; General Devices for Heat Treatment of Ferrous or Non-ferrous Metals or Alloys; Making Metal Malleable, e.g by Decarburisation or Tempering
C21D 7/10 (20130101) Original (OR) Class

Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys
C22F 1/06 (20130101)
C22F 1/183 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010981 Narayanan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Vinod Narayanan (Davis, California);  Erfan Rasouli (Davis, California)
ABSTRACT The disclosed embodiments relate to a system that provides a polymer heat exchanger with internal microscale flow passages. The system includes a set of plates comprised of a polymer that includes internal microscale flow passages, which are configured to carry a liquid. The set of plates is organized into a stack, wherein consecutive plates in the stack are separated by fins to form intervening air passages. The system includes a liquid flow pathway, which flows from a liquid inlet, through the internal microscale flow passages in the stack of plates, to a liquid outlet. It also includes an airflow pathway, which flows from an airflow inlet, through the intervening air passages between the consecutive plates in the stack of plates, to an airflow outlet. The liquid flow pathway flows in a direction opposite to a direction of the airflow pathway to provide a counterflow design that optimizes heat transfer between the liquid flow pathway and the airflow pathway.
FILED Wednesday, January 13, 2021
APPL NO 17/148359
CURRENT CPC
Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening
F24F 1/0067 (20190201) Original (OR) Class
F24F 1/00077 (20190201)

Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems
F25B 9/002 (20130101)
F25B 30/02 (20130101)

Details of Heat-exchange and Heat-transfer Apparatus, of General Application
F28F 3/022 (20130101)
F28F 3/048 (20130101)
F28F 2250/106 (20130101)
F28F 2255/143 (20130101)
F28F 2260/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011057 Brown et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
United States Army (USA)
Department of the Navy (DON)
Naval Research Laboratory (NRL)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)
INVENTOR(S) Robert F. Brown (Summerland Key, Florida);  Gregory M. Smith (Alexandria, Virginia);  Christopher Brady (Bradenton, Florida)
ABSTRACT A cooling system for a cold spray nozzle or a thermal spray barrel and a fabrication method thereof are provided. The cooling system includes a sleeve with cooling fins that encapsulate a spray nozzle or barrel to enable heat transfer from the nozzle or barrel to the fins and then to the external ambient environment. The sleeve may optionally include one or more channels with cooling tubes to enable enhanced cooling with a cooling medium flowing through the tubes and across the fins.
FILED Tuesday, June 22, 2021
APPL NO 17/354780
CURRENT CPC
Details of Heat-exchange and Heat-transfer Apparatus, of General Application
F28F 1/26 (20130101) Original (OR) Class

Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance
F41A 21/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011089 Garan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
U.S. Navy
Office of Naval Research (ONR)
United States Navy (USN)
APPLICANT(S) BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S) BAE Systems Information and Electronic Systems Integration Inc. (, None)
INVENTOR(S) Jacob D. Garan (Honolulu, Hawaii);  Mark S. Branham (Oro Valley, Arizona);  Christopher E. Saxer (Southport, North Carolina)
ABSTRACT A splitting and recombining optical component with an increased field of view while maintaining or only minimally increasing the space requirements therefor is provided. Further, the combination of the changes in physical geometry and refractive index of the beam splitting and recombining optical device can increase the field of view of a system while maintaining, or even reducing, the mass of the system in which the present beam splitting and recombining optic may be utilized
FILED Thursday, July 09, 2020
APPL NO 16/924876
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 9/02022 (20130101) Original (OR) Class
G01B 9/02068 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011161 Han et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea);  CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
ASSIGNEE(S) SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea);  CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California)
INVENTOR(S) Seunghoon Han (Seoul, South Korea);  Amir Arbabi (Pasadena, California);  Andrei Faraon (Pasadena, California);  Ehsan Arbabi (Pasadena, California)
ABSTRACT A spectrometer includes a transparent substrate including a first surface and a second surface that face each other and are substantially parallel to each other; a slit provided on the first surface and through which light is incident onto the transparent substrate; a spectrum optical system including metasurface including a plurality of nanostructures that are two-dimensionally arranged and satisfy a sub-wavelength scattering condition, wherein the metasurface includes a focusing metasurface which includes first nanostructures of the plurality of nanostructures, and is configured to reflect, disperse, and focus the light incident thereon through the slit, at different angles based on respective wavelengths; and a sensor configured to receive the light from the focusing metasurface. When L is a total length of an optical path from the slit to the sensor and D is a thickness of the transparent substrate, L and D satisfy the following inequality: L/D>3.
FILED Monday, September 27, 2021
APPL NO 17/486326
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 20/00 (20130101)

Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 3/0205 (20130101)
G01J 3/0208 (20130101) Original (OR) Class
G01J 3/0224 (20130101)
G01J 3/0256 (20130101)
G01J 3/0259 (20130101)
G01J 3/447 (20130101)
G01J 3/2803 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011163 Shi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) University of South Florida (Tampa, Florida)
ASSIGNEE(S) The University of Rochester (Rochester, New York);  University of South Florida (Tampa, Florida)
INVENTOR(S) Zhimin Shi (Tampa, Florida);  Darrick Hay (Brandon, Florida);  Ziyi Zhu (Tampa, Florida);  Yiyu Zhou (Rochester, New York);  Robert W. Boyd (Webster, New York)
ABSTRACT An apparatus measures the transverse profile of vectorial optical field beams, including both the phase and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.
FILED Monday, July 19, 2021
APPL NO 17/379507
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 4/04 (20130101) Original (OR) Class
G01J 11/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011300 Ramsey et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) The University of North Carolina at Chapel Hill (Chapel Hil, North Carolina)
ASSIGNEE(S)
INVENTOR(S) John Michael Ramsey (Chapel Hill, North Carolina);  William Hampton Henley (Chapel Hill, North Carolina);  Thomas Linz (Chapel Hill, North Carolina)
ABSTRACT Decoding methods are provided for identifying populations in assays, particularly multiplexing assays and those associated with fluidic devices.
FILED Thursday, April 29, 2021
APPL NO 17/244257
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/542 (20130101) Original (OR) Class
G01N 33/54313 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011363 Rupper et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Secretary of the Army (SECARMY)
APPLICANT(S) The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Greg Rupper (Silver Spring, Maryland);  John Suarez (Brooklyn, New York);  Sergey Rudin (Dayton, Maryland);  Meredith Reed (Perry Hall, Maryland);  Michael Shur (Latham, New York)
ABSTRACT Various embodiments are described that relate to failure determination for an integrated circuit. An integrated circuit can be tested to determine if the integrated circuit is functioning properly. The integrated circuit can be subjected to a specific radiation such that the integrated circuit produces a response. This response can be compared against an expected response to determine if the response matches the expected response. If the response does not match the expected response, then the integrated circuit fails the test. If the response matches the expected response, then the integrated circuit passes the test.
FILED Tuesday, December 15, 2020
APPL NO 17/121851
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/311 (20130101) Original (OR) Class
G01R 31/2656 (20130101)
G01R 31/2815 (20130101)
G01R 31/318533 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011383 Barry et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Materiel Command (AFMC)
U.S. Air Force
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) John F. Barry (Arlington, Massachusetts);  Reed Anderson Irion (Belmont, Massachusetts);  Jessica Kedziora (Shirley, Massachusetts);  Matthew Steinecker (Medford, Massachusetts);  Daniel K. Freeman (Reading, Massachusetts);  Danielle A. Braje (Winchester, Massachusetts)
ABSTRACT Ferrimagnetic oscillator magnetometers do not use lasers to stimulate fluorescence emission from defect centers in solid-state hosts (e.g., nitrogen vacancies in diamonds). Instead, in a ferrimagnetic oscillator magnetometer, the applied magnetic field shifts the resonance of entangled electronic spins in a ferrimagnetic crystal. These spins are entangled and can have an ensemble resonance linewidth of approximately 370 kHz to 10 MHz. The resonance shift produces microwave sidebands with amplitudes proportional to the magnetic field strength at frequencies proportional to the magnetic field oscillation frequency. These sidebands can be coherently averaged, digitized, and coherently processed, yielding magnetic field measurements with sensitivities possibly approaching the spin projection limit of 1 attotesla/√{square root over (Hz)}. The encoding of magnetic signals in frequency rather than amplitude relaxes or removes otherwise stringent requires on the digitizer.
FILED Wednesday, May 12, 2021
APPL NO 17/317983
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/02 (20130101) Original (OR) Class

Electric Digital Data Processing
G06F 3/046 (20130101)

Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits
H03B 15/006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011512 Ramachandran et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Siddharth Ramachandran (Boston, Massachusetts);  Zelin Ma (Boston, Massachusetts)
ABSTRACT An optical fiber system exploits a principle of topological confinement for guided higher-order modes, in contrast to more conventional total-internal-reflection (TIR) confinement. The optical fiber has a geometry and index profile defining a cutoff wavelength for a predetermined L-mode of optical signal propagation in the optical fiber, where L is azimuthal mode index. An optical source subsystem is coupled to the optical fiber to establish an optical signal propagating in the optical fiber, wherein the optical signal has the predetermined L-mode and a wavelength being either (1) at least 15% above the cutoff wavelength such that the optical beam propagates as a topologically confined mode, or (2) sufficiently above the cutoff wavelength that, based on the L-mode of the optical beam, the optical beam propagates as a topologically confined mode having propagation loss less than 3 dB/meter.
FILED Sunday, May 09, 2021
APPL NO 17/315314
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/14 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011646 Semmlinger et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Defense Threat Reduction Agency (DTRA)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) William Marsh Rice University (Houston, Texas);  Academia Sinica (Taipei, Taiwan)
ASSIGNEE(S) William Marsh Rice University (Houston, Texas);  Academia Sinica (Taipei, Taiwan)
INVENTOR(S) Michael Semmlinger (Houston, Texas);  Ming Lun Tseng (Taipei, Taiwan);  Jian Yang (Houston, Texas);  Ming Zhang (Houston, Texas);  Din Ping Tsai (Taipei, Taiwan);  Liangliang Dong (Houston, Texas);  Arash Ahmadivand (Houston, Texas);  Peter Nordlander (Houston, Texas);  Nancy Jean Halas (Houston, Texas)
ABSTRACT A harmonic light-generating metasurface includes a base substrate and a plurality of structures, that include nonlinear material, that are disposed in a pattern on a surface of the base substrate. Each structure of the plurality of structures individually supports a magnetic dipole mode. An electromagnetic field enhancement of the magnetic dipole mode induces generation of a harmonic signal by the plurality of structures. Alternatively, a harmonic light-generating metasurface, includes a base substrate, a supporting substrate that includes a nonlinear material, and a plurality of paired structures disposed in a pattern on a surface of the supporting substrate. Each paired structure, of the plurality of paired structures, collectively supports a toroidal dipole mode. An electromagnetic field enhancement of the toroidal dipole mode penetrates the supporting substrate to induce generation of a harmonic signal by the supporting substrate.
FILED Tuesday, October 01, 2019
APPL NO 17/281814
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/37 (20130101) Original (OR) Class
G02F 1/354 (20210101)
G02F 2202/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011664 Talapin et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Dmitri V. Talapin (La Grange Park, Illinois);  Yuanyuan Wang (Nanjing, China PRC);  Jia-Ahn Pan (Chicago, Illinois);  Haoqi Wu (Chicago, Illinois)
ABSTRACT Ligand-capped inorganic particles, dispersions of the ligand-capped inorganic particles, and films composed of the ligand-capped inorganic particles are provided. Also provided are methods of patterning the films and electronic, photonic, and optoelectronic devices that incorporate the films. The ligands include bifunctional ligands and two-component ligand systems that include a photosensitive group, cation, or molecule.
FILED Friday, October 11, 2019
APPL NO 17/283457
CURRENT CPC
Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor;
G03F 7/008 (20130101)
G03F 7/20 (20130101)
G03F 7/32 (20130101)
G03F 7/0045 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012060 Fok et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Femtosense, Inc. (Palo Alto, California)
ASSIGNEE(S) Femtosense, Inc. (Palo Alto, California)
INVENTOR(S) Sam Brian Fok (San Leandro, California);  Alexander Smith Neckar (Redwood City, California)
ABSTRACT Systems, apparatus, and methods for thread-based scheduling within a multicore processor. Neural networking uses a network of connected nodes (aka neurons) to loosely model the neuro-biological functionality found in the human brain. Various embodiments of the present disclosure use thread dependency graphs analysis to decouple scheduling across many distributed cores. Rather than using thread dependency graphs to generate a sequential ordering for a centralized scheduler, the individual thread dependencies define a count value for each thread at compile-time. Threads and their thread dependency count are distributed to each core at run-time. Thereafter, each core can dynamically determine which threads to execute based on fulfilled thread dependencies without requiring a centralized scheduler.
FILED Monday, July 05, 2021
APPL NO 17/367521
CURRENT CPC
Electric Digital Data Processing
G06F 9/3802 (20130101)
G06F 9/3818 (20130101)
G06F 9/3838 (20130101) Original (OR) Class
G06F 11/3024 (20130101)
G06F 11/3433 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/063 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012213 Ganti et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)
INVENTOR(S) Raghu Kiran Ganti (Elmsford, New York);  Shen Li (Urbana, Illinois);  Mudhakar Srivatsa (White Plains, New York)
ABSTRACT A spatial-temporal storage method, system, and non-transitory computer readable medium include dynamically managing a plurality of region servers for querying spatiotemporal data in noSQL databases.
FILED Thursday, September 23, 2021
APPL NO 17/482651
CURRENT CPC
Electric Digital Data Processing
G06F 16/275 (20190101)
G06F 16/284 (20190101)
G06F 16/1844 (20190101) Original (OR) Class
G06F 16/2452 (20190101)
G06F 16/2453 (20190101)
G06F 16/2477 (20190101)
G06F 16/9537 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012575 Fok et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Femtosense, Inc. (Palo Alto, California)
ASSIGNEE(S) Femtosense, Inc. (Palo Alto, California)
INVENTOR(S) Sam Brian Fok (San Leandro, California);  Alexander Smith Neckar (Redwood City, California);  Scott Henry Reid (Palo Alto, California)
ABSTRACT Methods and apparatus for localized processing within multicore neural networks. Unlike existing solutions that rely on commodity software and hardware to perform “brute force” large scale neural network processing the various techniques described herein map and partition a neural network into the hardware limitations of a target platform. Specifically, the various implementations described herein synergistically leverage localization, sparsity, and distributed scheduling, to enable neural network processing within embedded hardware applications. As described herein, hardware-aware mapping/partitioning enhances neural network performance by e.g., avoiding pin-limited memory accesses, processing data in compressed formats/skipping unnecessary operations, and decoupling scheduling between cores.
FILED Monday, July 05, 2021
APPL NO 17/367512
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/063 (20130101) Original (OR) Class
G06N 3/0454 (20130101)
G06N 3/0481 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012598 Fok et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Femtosense, Inc. (Palo Alto, California)
ASSIGNEE(S) Femtosense, Inc. (Palo Alto, California)
INVENTOR(S) Sam Brian Fok (San Leandro, California);  Alexander Smith Neckar (Redwood City, California);  Manish Shrivastava (Pleasanton, California)
ABSTRACT Methods and apparatus for matrix and vector storage and operations are disclosed. Vectors and matrices may be represented differently to further enhance performance of operations. Exemplary embodiments compress sparse neural network data structures based on actual, non-null, connectivity (rather than all possible connections). This greatly reduces storage requirements as well as computational complexity. In some variants, the compression and reduction in complexity is sized to fit within the memory footprint and processing capabilities of a core. The exemplary compression schemes represent sparse matrices with links to compressed column data structures, where each compressed column data structure only stores non-null entries to optimize column-based lookups of non-null entries. Similarly, sparse vector addressing skips nulled entries to optimize for vector-specific non-null multiply-accumulate operations.
FILED Monday, July 05, 2021
APPL NO 17/367517
CURRENT CPC
Electric Digital Data Processing
G06F 16/901 (20190101)
G06F 17/16 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/10 (20130101) Original (OR) Class

Coding; Decoding; Code Conversion in General
H03M 7/702 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012619 ROQUES-CARMES et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Charles ROQUES-CARMES (Cambridge, Massachusetts);  Yichen Shen (Cambridge, Massachusetts);  Li JING (Cambridge, Massachusetts);  Tena DUBCEK (Cambridge, Massachusetts);  Scott A. SKIRLO (Boston, Massachusetts);  Hengameh BAGHERIANLEMRASKI (Cambridge, Massachusetts);  Marin SOLJACIC (Belmont, Massachusetts)
ABSTRACT A photonic parallel network can be used to sample combinatorially hard distributions of Ising problems. The photonic parallel network, also called a photonic processor, finds the ground state of a general Ising problem and can probe critical behaviors of universality classes and their critical exponents. In addition to the attractive features of photonic networks—passivity, parallelization, high-speed and low-power—the photonic processor exploits dynamic noise that occurs during the detection process to find ground states more efficiently.
FILED Monday, April 26, 2021
APPL NO 17/239830
CURRENT CPC
Electric Digital Data Processing
G06F 17/16 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/084 (20130101)
G06N 3/0445 (20130101)
G06N 3/0454 (20130101)
G06N 3/0472 (20130101)
G06N 3/0675 (20130101)
G06N 7/005 (20130101)
G06N 10/00 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012646 RUBENSTEIN et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) BROWN UNIVERSITY (, None)
ASSIGNEE(S)
INVENTOR(S) Brenda RUBENSTEIN (Providence, Rhode Island);  Jacob Karl ROSENSTEIN (Providence, Rhode Island);  Christopher ARCADIA (Providence, Rhode Island);  Shui Ling CHEN (Harrisburg, Pennsylvania);  Amanda Doris DOMBROSKI (Cranston, Rhode Island);  Joseph D. GEISER (Barrington, Rhode Island);  Eamonn KENNEDY (West Warwick, Rhode Island);  Eunsuk KIM (Providence, Rhode Island);  Kady M. OAKLEY (North Attleboro, Massachusetts);  Sherief REDA (Barrington, Rhode Island);  Christopher ROSE (Providence, Rhode Island);  Jason Kelby SELLO (Tiverton, Rhode Island);  Hokchhay TANN (Providence, Rhode Island);  Peter WEBER (Barrington, Rhode Island)
ABSTRACT The invention provides methods for computing with chemicals by encoding digital data into a plurality of chemicals to obtain a dataset; translating the dataset into a chemical form; reading the data set; querying the dataset by performing an operation to obtain a perceptron; and analyzing the perceptron for identifying chemical structure and/or concentration of at least one of the chemicals, thereby developing a chemical computational language. The invention demonstrates a workflow for representing abstract data in synthetic metabolomes. Also presented are several demonstrations of kilobyte-scale image data sets stored in synthetic metabolomes, recovered at >99% accuracy.
FILED Monday, July 19, 2021
APPL NO 17/378988
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 99/007 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012902 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
National Eye Institute (NEI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Jacob Antunes (Cincinnati, Ohio);  Zhouping Wei (Cleveland, Ohio);  Pallavi Tiwari (Wexford, Pennsylvania);  Satish E. Viswanath (Pepper Pike, Ohio);  Charlems Alvarez Jimenez (Bogotá, Colombia)
ABSTRACT The present disclosure, in some embodiments, relates to a non-transitory computer-readable medium storing computer-executable instructions. The computer readable medium is configured to cause a processor to access an image volume of a rectum comprising a rectal tumor. A forward mapping is generated based on non-rigidly registering a healthy rectal atlas to the image volume. The forward mapping is inverted to generate an inverse mapping from the image volume to the healthy rectal atlas. Based on the inverse mapping, a plurality of deformation vectors, associated with a deformation within a rectal wall of the rectum, are determined. Magnitude based deformation features and orientation based deformation features are computed from the plurality of deformation vectors. One or more of the magnitude based deformation features and one or more of the orientation based deformation features are utilized to determine a response of a patient to a chemoradiation treatment.
FILED Wednesday, September 22, 2021
APPL NO 17/481625
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/33 (20170101) Original (OR) Class
G06T 7/38 (20170101)
G06T 2207/10088 (20130101)
G06T 2207/30096 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/40 (20180101)
G16H 50/70 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012937 Lilley et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Undersea Warfare Center (NUWC)
APPLICANT(S) Cesium GS, Inc. (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Ian Lilley (Philadelphia, Pennsylvania);  Sean Lilley (Philadelphia, Pennsylvania);  Patrick Cozzi (Drexel Hill, Pennsylvania)
ABSTRACT Systems, methods, devices, and non-transitory media of various embodiments enable rendering of a time-dynamic (4D) volume dataset. Various embodiments may provide a method for responsive and high quality rendering of time-dynamic hierarchical level-of-detail voxel datasets. Various embodiments may provide a prioritization system that balances visual quality and temporal responsiveness even with slow network or filesystem speeds. Various embodiments may provide a compact and efficient storage format for time-dynamic and mixed-resolution voxel rendering on a graphics processing unit (GPU).
FILED Friday, July 09, 2021
APPL NO 17/372344
CURRENT CPC
Image Data Processing or Generation, in General
G06T 15/04 (20130101)
G06T 15/005 (20130101)
G06T 15/08 (20130101) Original (OR) Class
G06T 15/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013288 SPANIER et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Jonathan E. SPANIER (Bala Cynwyd, Pennsylvania);  Iryna S. GOLOVINA (Philadelphia, Pennsylvania);  Aleksandr V. PLOKHIKH (Philadelphia, Pennsylvania);  Mattias FALMBIGL (Syosset, New York)
ASSIGNEE(S)
INVENTOR(S) Jonathan E. SPANIER (Bala Cynwyd, Pennsylvania);  Iryna S. GOLOVINA (Philadelphia, Pennsylvania);  Aleksandr V. PLOKHIKH (Philadelphia, Pennsylvania);  Mattias FALMBIGL (Syosset, New York)
ABSTRACT Provided is the dielectric response of atomic layer-deposited and annealed polymorphic BaTiO3 and BaTiO3—Al2O3 bi-layer thin films based on nanocry stalline BaTiO3 containing the perovskite and hexagonal polymorphs. Also provided are BaTiO3 films having tuned Curie temperatures. Further provided are capacitive components, comprising: a plurality of films, the plurality of films comprising: a first grained film component, the first grained film component comprising at least one of SrTiO3, BaTiO3, and (Ba, Sr)TiO3, and the first grained film component being characterized as being at least partially polymorphic crystalline in nature; a second film component contacting the first grained film component, the second film component optionally comprising Al2O3, and the first grained film component optionally defining an average grain size of less than about 10 micrometers.
FILED Wednesday, November 13, 2019
APPL NO 17/293575
CURRENT CPC
Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 4/008 (20130101)
H01G 4/10 (20130101)
H01G 4/33 (20130101)
H01G 4/306 (20130101)
H01G 4/1227 (20130101) Original (OR) Class

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 28/56 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013719 CADY et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Secretary of the Air Force (SECAF)
APPLICANT(S) The Research Foundation for the State University of New York (Albany, New York);  GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S) Nathaniel CADY (Delmar, New York);  Karsten BECKMANN (Albany, New York);  Joseph VAN NOSTRAND (Rome, New York)
ABSTRACT A resistive random access memory (ReRAM) device includes a bottom electrode and a top electrode with a switching layer disposed therebetween. The bottom electrode has a top surface in contact with a bottom surface of the switching layer. The bottom electrode also has first and second sidewalls spaced apart by a first distance where the sidewalls contact the bottom surface of the switching layer. The switching layer has first and second sidewalls spaced apart by a second distance that is larger than the first distance. The top electrode is disposed over the switching layer. The first sidewall of the switching layer overhangs the first sidewall of the bottom electrode by an overhang distance of 5 nanometers or more. The second sidewall of the switching layer overhangs the second sidewall of the bottom electrode by an overhang distance of 5 nanometers or more.
FILED Monday, September 23, 2019
APPL NO 17/295920
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 45/08 (20130101)
H01L 45/146 (20130101)
H01L 45/1233 (20130101)
H01L 45/1253 (20130101) Original (OR) Class
H01L 45/1675 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013977 Zhou et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) Board of Regents, The University of Texas System (UsAustin, Texas)
ASSIGNEE(S)
INVENTOR(S) Weidong Zhou (Southlake, Texas);  Xiaochen Ge (Sugar Land, Texas)
ABSTRACT In one embodiment, a nanobeam cavity device includes an elongated waveguide having a central optical cavity, first and second lateral substrates that are positioned on opposed lateral sides of the waveguide, and carrier-injection beams that extend from the first and second lateral substrates to the central optical cavity of the elongated waveguide.
FILED Wednesday, July 07, 2021
APPL NO 17/369789
CURRENT CPC
Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical
H01S 5/11 (20210101)
H01S 5/026 (20130101) Original (OR) Class
H01S 5/1042 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220014280 Hutchinson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Secretary of the Navy (SECNAV)
APPLICANT(S) The Government of the United States, as represented by the Secretary of the Navy (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Meredith N. Hutchinson (Washington, District of Columbia);  Jonathan M. Nichols (Crofton, Maryland)
ABSTRACT Methods, apparatuses, and systems for removing noise from a received signal. A signal is received, at a controller, that was recorded by a sensor and emitted by a source. The signal includes a signal of interest component and a noise component. The noise component of the signal is sampled, and the sampled noise component of the signal is used to estimate a variance in the noise component. An energy of the signal of interest component of the signal is determined. A cumulative distribution function for the received signal is calculated, and a cumulative distribution function of the signal of interest component of the received signal is then calculated based on the estimated variance in the sampled noise component, the determined energy of the signal of interest component of the signal, and the calculated cumulative distribution function for the received signal.
FILED Monday, June 21, 2021
APPL NO 17/353766
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 29/26 (20130101)

Transmission
H04B 15/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220014347 TIAN et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
United States Air Force (USAF)
APPLICANT(S) INTELLIGENT FUSION TECHNOLOGY, INC. (Germantown, Maryland)
ASSIGNEE(S)
INVENTOR(S) Xin TIAN (Germantown, Maryland);  Genshe CHEN (Germantown, Maryland);  Khanh PHAM (Kirtland AFB, New Mexico);  Erik BLASCH (Arlington, Virginia)
ABSTRACT A method for emulating a communication system with fast changing link condition, applied to a testbed system including an interference emulator, a transmitter, and a receiver, includes: by the transmitter, generating code-word symbols, in an initial symbol sequence, according to information bits; evaluating an interference condition and a time duration for each code-word symbol; reordering the code-word symbols to a reordered symbol sequence based on interference conditions; evaluating a total time duration of code-word symbols under each interference condition; and transmitting the code-word symbols in the reordered symbol sequence. The method also includes: by the interference emulator, obtaining the total time duration of code-word symbols under each interference condition from the transmitter; and providing an emulated interference environment by ordering the time durations of different interference conditions. The start time for transmitting code-word symbols with an interference condition is synchronized with the start time for emulating the interference condition.
FILED Thursday, July 09, 2020
APPL NO 16/924853
CURRENT CPC
Transmission
H04B 17/373 (20150115)
H04B 17/3913 (20150115)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 5/1453 (20130101) Original (OR) Class
H04L 25/0204 (20130101)
H04L 25/03343 (20130101)
H04L 2025/03401 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 20220007677 Gibbons et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) PRAIRIE AQUATECH LLC (Brookings, South Dakota)
ASSIGNEE(S) PRAIRIE AQUATECH LLC (Brookings, South Dakota)
INVENTOR(S) William Gibbons (Brookings, South Dakota);  Michael L. Brown (Volga, South Dakota)
ABSTRACT The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.
FILED Friday, September 17, 2021
APPL NO 17/477676
CURRENT CPC
Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs
A23J 1/14 (20130101)
A23J 1/125 (20130101) Original (OR) Class
A23J 1/148 (20130101)

Fodder
A23K 10/14 (20160501)
A23K 10/38 (20160501)
A23K 20/147 (20160501)
A23K 40/20 (20160501)
A23K 40/25 (20160501)
A23K 50/80 (20160501)

Technologies for Adaptation to Climate Change
Y02A 40/818 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220007958 Grayson et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Matthew Allen Grayson (Evanston, Illinois);  Chulin Wang (Evanston, Illinois);  Claire Cecelia Onsager (Stoughton, Wisconsin);  Can Cenap Aygen (Chicago, Illinois);  Charles M. Costakis (Evanston, Illinois);  Lauren E. Lang (Boulder, Colorado);  Andreas Tzavelis (Demarest, New Jersey);  John Ashley Rogers (Wilmette, Illinois)
ABSTRACT The disclosed 2-D and 3-D tomographic resistance imaging method improves tomographic resistance image resolution by adopting an orthogonal basis with the maximum number of elements N to describe the maximum resolution resistivity map ρ(r), where this number of elements N is set according to the number of electrodes Q; by defining the orthogonal basis according to any known constraints in the problem, thereby enhancing the resolution where it is needed; by positioning electrodes to be sensitive to these basis functions; and by choosing current I and voltage V contact electrode pairs that maximize signal-to-noise ratio.
FILED Friday, November 29, 2019
APPL NO 17/295318
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0536 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008346 Wilson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Congressionally Directed Medical Research Programs (CDMRP)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) John T. Wilson (Nashville, Tennessee);  Daniel Shae (Nashville, Tennessee);  Dinh Chuong Nguyen (Phu Nhuan District, Ho Chi Minh, Viet Nam)
ABSTRACT A graft copolymer and a method of delivering an active agent to a subject are provided. The graft copolymer includes a polymer backbone, a hydrophilic segment grafted to the polymer backbone, a pH-responsive segment grafted to the polymer backbone, and an endosomal disruption segment grafted to the polymer backbone. The method of delivering an active agent to a subject includes encapsulating the active agent with the graft copolymer and administering the encapsulated active agent to the subject.
FILED Wednesday, October 30, 2019
APPL NO 17/290618
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5026 (20130101) Original (OR) Class

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 290/062 (20130101)
C08F 2438/03 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008347 Baxter et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Human Resource Development (HRD)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Ryan Baxter (Merced, California);  Sayantani Ghosh (Merced, California)
ABSTRACT Self-assembled organic ligand functionalized microcapsules encapsulating one or more substrates, which release the substrates upon activation with a power source, are provided. Compositions that include these microcapsules, as well as methods of making the microcapsules and releasing the encapsulated substrates are also provided. The structures, compositions and methods find use in a variety of applications, such as drug and cell encapsulation technologies, for direct delivery, control, and activation of medicines and therapies to specific tissues in a living host.
FILED Wednesday, November 20, 2019
APPL NO 17/296187
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0009 (20130101)
A61K 9/143 (20130101)
A61K 9/5015 (20130101)
A61K 9/5089 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008736 Babakhani et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California);  Texas Heart Institute (Houston, Texas)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  Texas Heart Institute (Houston, Texas)
INVENTOR(S) Aydin Babakhani (Los Angeles, California);  Hongming Lyu (Los Angeles, California);  Razavi Mehdi (Houston, Texas);  Mathews M. John (Houston, Texas);  Allison Post (Houston, Texas)
ABSTRACT Systems and methods for heart stimulation in accordance with embodiments of the invention are illustrated. One embodiment includes a heart stimulation system, including a first wirelessly powered, leadless pacemaker, including a wireless power receiver tuned to a first frequency, an energy harvesting circuitry, a stimulation circuitry, and a stimulation electrode, a controller, including a wireless power signal generator, a wireless power transmitter tuned to the frequency, a processor, and a memory containing a stimulation control application, where the stimulation control application directs the processor to generate a power transfer signal using the first wireless power signal generator, and transmit the power transfer signal using the wireless power transmitter, wherein the wirelessly powered, leadless pacemaker receives the power transfer signal using the first wireless power receiver, and when receiving the power transfer signal, the energy harvesting circuitry stores power received via the wireless power receiver in at least one capacitor.
FILED Wednesday, November 20, 2019
APPL NO 17/295005
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/3684 (20130101)
A61N 1/3756 (20130101) Original (OR) Class
A61N 1/3787 (20130101)
A61N 1/37288 (20130101)
A61N 1/37512 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008970 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Fall River, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Jack Rowbottom (Swansea, Massachusetts);  Nicole Neff (Colorado Springs, Colorado)
ABSTRACT Systems and methods for controlling extraction of landfill gas from a landfill via a gas extraction system are provided herein. According to some aspects of the technology, there is provided site-level control methods for globally controlling one or more wells based on one or more characteristics of aggregate landfill gas collected from a plurality of wells at a gas output. According to some aspects of the technology, there is provided well-level control methods for locally controlling a first well based on or more characteristics of landfill gas collected from the first well. According to further aspects of the technology, there is provided hybrid control methods for making adjustments to a respective well based on both site-level and well-level control methods.
FILED Monday, July 13, 2020
APPL NO 16/927471
CURRENT CPC
Disposal of Solid Waste
B09B 1/006 (20130101)
B09B 3/0016 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 43/123 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008971 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Fall River, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Jack Rowbottom (Swansea, Massachusetts);  Nicole Neff (Colorado Springs, Colorado)
ABSTRACT Systems and methods for controlling extraction of landfill gas from a landfill via a gas extraction system are provided herein. According to some aspects of the technology, there is provided site-level control methods for globally controlling one or more wells based on one or more characteristics of aggregate landfill gas collected from a plurality of wells at a gas output. According to some aspects of the technology, there is provided well-level control methods for locally controlling a first well based on or more characteristics of landfill gas collected from the first well. According to further aspects of the technology, there is provided hybrid control methods for making adjustments to a respective well based on both site-level and well-level control methods.
FILED Monday, July 13, 2020
APPL NO 16/927479
CURRENT CPC
Reclamation of Contaminated Soil
B09C 1/005 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 34/00 (20130101)
E21B 47/06 (20130101)
E21B 49/0875 (20200501)

Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure
G01L 11/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/004 (20130101)
G01N 33/0044 (20130101)
G01N 33/0047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008972 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Fall River, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Jack Rowbottom (Swansea, Massachusetts);  Nicole Neff (Colorado Springs, Colorado)
ABSTRACT Systems and methods for controlling extraction of landfill gas from a landfill via a gas extraction system are provided herein. According to some aspects of the technology, there is provided site-level control methods for globally controlling one or more wells based on one or more characteristics of aggregate landfill gas collected from a plurality of wells at a gas output. According to some aspects of the technology, there is provided well-level control methods for locally controlling a first well based on or more characteristics of landfill gas collected from the first well. According to further aspects of the technology, there is provided hybrid control methods for making adjustments to a respective well based on both site-level and well-level control methods.
FILED Monday, July 13, 2020
APPL NO 16/927482
CURRENT CPC
Reclamation of Contaminated Soil
B09C 1/005 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 34/00 (20130101)
E21B 47/06 (20130101)
E21B 49/0875 (20200501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/004 (20130101)
G01N 33/0044 (20130101)
G01N 33/0047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008973 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Fall River, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Jack Rowbottom (Swansea, Massachusetts);  Nicole Neff (Colorado Springs, Colorado)
ABSTRACT Systems and methods for controlling extraction of landfill gas from a landfill via a gas extraction system are provided herein. According to some aspects of the technology, there is provided site-level control methods for globally controlling one or more wells based on one or more characteristics of aggregate landfill gas collected from a plurality of wells at a gas output. According to some aspects of the technology, there is provided well-level control methods for locally controlling a first well based on or more characteristics of landfill gas collected from the first well. According to further aspects of the technology, there is provided hybrid control methods for making adjustments to a respective well based on both site-level and well-level control methods.
FILED Monday, July 13, 2020
APPL NO 16/927488
CURRENT CPC
Reclamation of Contaminated Soil
B09C 1/005 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 34/00 (20130101)
E21B 47/06 (20130101)
E21B 49/0875 (20200501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/004 (20130101)
G01N 33/0044 (20130101)
G01N 33/0047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009940 Guo
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Maolin Guo (Dartmouth, Massachusetts)
ABSTRACT The present disclosure relates to compounds of Formula I, II, or III and compositions of the same, which are reversible off-on or ratiometric fluorescent iron sensors and are useful in live-cell imaging of labile iron ions and their quantification in subcellular compartments, as well as treatment of diseases associated with iron dyshomoestasis.
FILED Thursday, February 01, 2018
APPL NO 16/485469
CURRENT CPC
Heterocyclic Compounds
C07D 491/22 (20130101)
C07D 491/107 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/643 (20130101)
G01N 33/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009944 Beaudry et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Oregon State University (Corvallis, Oregon)
ASSIGNEE(S) Oregon State University (Corvallis, Oregon)
INVENTOR(S) Christopher M. Beaudry (Corvallis, Oregon);  Xuan Ju (Danbury, Connecticut)
ABSTRACT Disclosed herein are embodiments of a compound having a Formula I or a salt, solvate, N-oxide, prodrug, diastereomer or enantiomer thereof. Also disclosed are derivative compounds made from the compound of Formula I. Certain derivative compounds have a Formula V-2, or a salt, solvate, N-oxide, prodrug, diastereomer or enantiomer thereof. Also disclosed are method for making and using the disclosed compounds. Certain disclosed embodiments are useful for treating and/or preventing certain diseases and/or disorders, including proliferation diseases, such as leukemia.
FILED Thursday, September 09, 2021
APPL NO 17/470608
CURRENT CPC
Heterocyclic Compounds
C07D 491/153 (20130101)
C07D 498/06 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010055 Nuckolls et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
INVENTOR(S) Colin Nuckolls (New York, New York);  Xavier Roy (New York, New York);  Jake Carter Russell (New York, New York);  Samuel R. Peurifoy (New York, New York)
ABSTRACT The present disclosure provides organic compounds having pseudocapacitive performance and methods of preparing said compounds. The organic compounds can include perylene diamine (PDI) subunits and hexaazatrinaphthylene (HATN) subunits.
FILED Friday, February 19, 2021
APPL NO 17/180046
CURRENT CPC
Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 61/122 (20130101) Original (OR) Class
C08G 2261/12 (20130101)
C08G 2261/228 (20130101)
C08G 2261/411 (20130101)
C08G 2261/3241 (20130101)

Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 11/48 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010160 Zhong et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
Division of Industrial Innovation and Partnerships (IIP)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) The Research Foundation for The State University of new York (Binghamton, New York)
ASSIGNEE(S)
INVENTOR(S) Chuan-Jian Zhong (Endwell, New York);  Shan Yan (Medford, New York);  Shiyao Shan (Vestal, New York);  Ning He (Xiamen, China PRC);  Ning Kang (Irvine, California);  Jin Luo (Vestal, New York)
ABSTRACT A low temperature sinterable copper nanoparticle or nanowire, comprising gold, zinc, nickel, tin, or aluminum as an alloying metal, and a capping agent. The nanoparticles or nanowires may be deposited on porous or fibrous substrates, the capping agent desorbed, and sintered at low temperature to form conductive traces or sensing elements. The nanoparticles or nanowires may be deposited by aerosol jet, inkjet or dispenser printers, for example.
FILED Friday, July 09, 2021
APPL NO 17/305583
CURRENT CPC
Printing, Duplicating, Marking, or Copying Processes; Colour Printing,
B41M 5/0023 (20130101)
B41M 7/009 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 11/033 (20130101)
C09D 11/037 (20130101)
C09D 11/52 (20130101) Original (OR) Class

Alloys
C22C 9/00 (20130101)

Pulp Compositions; Preparation Thereof Not Covered by Subclasses D21C or D21D; Impregnating or Coating of Paper; Treatment of Finished Paper Not Covered by Class B31 or Subclass D21G; Paper Not Otherwise Provided for
D21H 19/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010284 Silpe et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Molecular and Cellular Biosciences (MCB)
APPLICANT(S) The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S) The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S) Justin E. Silpe (Lawrenceville, New Jersey);  Bonnie L. Bassler (Princeton, New Jersey)
ABSTRACT Disclosed are recombinant phages that infect and kill bacterial hosts in response to user-defined inputs. The components that encode the user-defined inputs can be combined, such that multiple inputs are maintained on a single recombinant phage, enabling precise control over the targeting strategy. The phages can be engineered to kill a specific bacterial species or multiple species simultaneously. Recombinant phages can also be engineered to harbor fluorescent and bioluminescent reporter genes that enable them to be used for tracking, detection, and in biosensing applications. Recombinant phages can also be used to lyse bacterial cells that produce recombinant proteins, as a rapid method to enable extraction and high-level purification of potentially valuable and/or industrially important proteins. Also disclosed is a system that can also be used to control the activity of a protein of interest, by taking advantage of an interaction between Qtip and a phage repressor protein; a phage repressor protein can be fused to a protein-of-interest, and by controlling the expression of qtip, the phage repressor protein fused to a protein-of-interest will be inactivated when Qtip is expressed and interacts with the phage repressor protein.
FILED Thursday, October 31, 2019
APPL NO 17/289336
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101) Original (OR) Class
C12N 15/73 (20130101)
C12N 15/74 (20130101)
C12N 2795/10121 (20130101)
C12N 2795/10122 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010307 Mischel et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Human Genome Research Institute (NHGRI)
National Institute of General Medical Sciences (NIGMS)
NIH Office of the Director (NIHOD)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) The Regents of the University of California (Oakland, California);  Ludwig Institute for Cancer Research Ltd (La Jolla, California);  The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Paul Mischel (La Jolla, California);  Bing Ren (La Jolla, California);  Kristen Turner (La Jolla, California);  Sihan Wu (La Jolla, California);  Vineet Bafna (Oakland, California);  Nam-phuong Nguyen (Oakland, California);  Howard Chang (Stanford, California)
ABSTRACT Provided herein are, inter alia, methods and compositions to detect, monitor and treat cancer, wherein the cancer includes amplified extrachromosomal oncogenes. The methods are useful for personalized treatment and exploit differential expression and chromatin structure of extrachromosomal oncogenes in cancer cells.
FILED Tuesday, December 10, 2019
APPL NO 17/311980
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7105 (20130101)
A61K 45/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/111 (20130101) Original (OR) Class
C12N 15/113 (20130101)
C12N 2310/11 (20130101)
C12N 2310/20 (20170501)
C12N 2320/31 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010317 BORDENSTEIN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Organismal Systems (IOS)
APPLICANT(S) VANDERBILT UNIVERSITY (Nashville, Tennessee);  lNSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNI (Paris, France);  THE UNIVERSITY OF CHICAGO (Chicago, Israel)
ASSIGNEE(S)
INVENTOR(S) Sarah BORDENSTEIN (Nashville, Tennessee);  Julie REVEILLAUD (Montpellier, France);  A. Murat EREN (Chicago, Illinois);  Seth BORDENSTEIN (Nashville, Tennessee)
ABSTRACT The present disclosure relates to plasmids, systems, and methods for the transformation of Wolbachia. Disclosed herein are plasmids and systems for use in methods of transforming Wolbachia. The inventors have identified extrachromosomal plasmids within Wolbachia. Disclosed herein is a non-naturally occurring plasmid comprising a nucleic acid encoding a transposase. Disclosed herein is a method for transforming a Wolbachia cell, comprising introducing a non-naturally occurring plasmid into the cell, wherein the plasmid comprises a nucleic acid sequence capable of transforming a Wolbachia cell.
FILED Friday, November 15, 2019
APPL NO 17/293634
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/74 (20130101) Original (OR) Class
C12N 2800/101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011249 Yao et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Berkeley National Laboratory (LBNL)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Norman Ying Yao (Berkeley, California);  Raymond Jeanloz (Berkeley, California);  Thomas Mittiga (Berkeley, California);  Prabudhya Bhattacharyya (Berkeley, California);  Thomas J. Smart (Berkeley, California);  Francisco Machado (Berkeley, California);  Bryce Kobrin (Berkeley, California);  Soonwon Choi (Berkeley, California);  Joel Moore (Berkeley, California);  Satcher Hsieh (Berkeley, California);  Chong Zu (Berkeley, California)
ABSTRACT A pressure chamber has a chamber wall. The chamber wall includes a sensor integrated within the chamber wall, wherein the sensor integrated in the chamber wall comprises defects. A method of determining an effect of pressure on a material is further described. The method includes applying pressure to a material within a pressure chamber and to a pressure chamber wall of the pressure chamber, where the pressure chamber wall has defects. A signal from the defects is sensed while the material and the pressure chamber wall are under pressure. A property of the material is determined based on the sensed signal.
FILED Thursday, December 19, 2019
APPL NO 17/312893
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 32/28 (20170801)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 3/12 (20130101)
G01N 23/20041 (20130101) Original (OR) Class
G01N 2203/0488 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/46 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011270 Arvanitis et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Costas Arvanitis (Atlanta, Georgia);  Arpit Patel (Atlanta, Georgia);  Scott Joseph Schoen, Jr. (Atlanta, Georgia);  Zhigen Zhao (Atlanta, Georgia)
ABSTRACT This disclosure describes systems and methods for ultrasound imaging and targeting. In one example, the systems and methods improve targeting and imaging through a heterogenous medium by using the angular spectrum approach (ASA) alone or in combination with passive acoustic mapping (PAM). In another example, the systems and methods improve the ultrasound imaging of vessels using microbubbles. The imaging of the vessels is also aided by the ASA and PAM. A closed loop controller is described that adjusts the ultrasound pressure provided to a region of interest to a desired pressure based at least in part on the harmonic, ultra-harmonic, sub-harmonic, or broadband frequency ranges for the microbubbles.
FILED Thursday, November 07, 2019
APPL NO 17/291504
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 29/221 (20130101)
G01N 29/348 (20130101)
G01N 29/0654 (20130101) Original (OR) Class
G01N 2291/102 (20130101)
G01N 2291/02475 (20130101)
G01N 2291/02483 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011302 Johnson, JR. et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Graduate Education (DGE)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Alan T. Johnson, JR. (Philadelphia, Pennsylvania);  Ye Lu (Philadelphia, Pennsylvania);  Joseph J. Mitala, JR. (Rockville, Maryland);  Bohdana Discher (Philadelphia, Pennsylvania);  Brett R. Goldsmith (Philadelphia, Pennsylvania)
ABSTRACT Provided are devices and methods featuring a nanoelectronic interface between graphene devices (for example, field effect transistors or FETs) and biomolecules such as proteins, which in turn provides a pathway for production of bioelectronic devices that combine functionalities of the biomolecular and inorganic components. In one exemplary application, one may functionalize graphene FETs with fluorescent proteins to yield hybrids that respond to light at wavelengths defined by the optical absorption spectrum of the protein. The devices may also include graphene in electronic communication with a bio-molecule that preferentially binds to a particular analyte.
FILED Monday, September 13, 2021
APPL NO 17/473412
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/582 (20130101)
G01N 33/54306 (20130101) Original (OR) Class
G01N 33/54353 (20130101)
G01N 33/54373 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011512 Ramachandran et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Siddharth Ramachandran (Boston, Massachusetts);  Zelin Ma (Boston, Massachusetts)
ABSTRACT An optical fiber system exploits a principle of topological confinement for guided higher-order modes, in contrast to more conventional total-internal-reflection (TIR) confinement. The optical fiber has a geometry and index profile defining a cutoff wavelength for a predetermined L-mode of optical signal propagation in the optical fiber, where L is azimuthal mode index. An optical source subsystem is coupled to the optical fiber to establish an optical signal propagating in the optical fiber, wherein the optical signal has the predetermined L-mode and a wavelength being either (1) at least 15% above the cutoff wavelength such that the optical beam propagates as a topologically confined mode, or (2) sufficiently above the cutoff wavelength that, based on the L-mode of the optical beam, the optical beam propagates as a topologically confined mode having propagation loss less than 3 dB/meter.
FILED Sunday, May 09, 2021
APPL NO 17/315314
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/14 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011535 Monroe et al.
FUNDED BY
Department of Energy (DOE)
Basic Energy Sciences (BES)
Los Alamos National Laboratory (LANL)
Los Alamos National Security, LLC (LANS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) James Alan Monroe (College Station, Texas);  David Scott Content (Spring, Texas);  Jeremy Sean McAllister (Bryan, Texas);  Jay Russell Zgarba (Sugar Land, Texas)
ASSIGNEE(S)
INVENTOR(S) James Alan Monroe (College Station, Texas);  David Scott Content (Spring, Texas);  Jeremy Sean McAllister (Bryan, Texas);  Jay Russell Zgarba (Sugar Land, Texas)
ABSTRACT A lens alignment system and method is disclosed. The disclosed system/method integrates one or more lens retaining members/tubes (LRM/LRT) and focal length spacers (FLS) each comprising a metallic material product (MMP) specifically manufactured to have a thermal expansion coefficient (TEC) in a predetermined range via selection of the individual MMP materials and an associated MMP manufacturing process providing for controlled TEC. This controlled LRM/LRT TEC enables a plurality of optical lenses (POL) fixed along a common optical axis (COA) by the LRM/LRT to maintain precise interspatial alignment characteristics that ensure consistent and/or controlled series focal length (SFL) within the POL to generate a thermally neutral optical system (TNOS). Integration of the POL using this LRM/LRT/FLS lens alignment system reduces the overall TNOS implementation cost, reduces the overall TNOS mass, reduces TNOS parts component count, and increases the reliability of the overall optical system.
FILED Tuesday, September 07, 2021
APPL NO 17/467719
CURRENT CPC
Alloys
C22C 14/00 (20130101)

Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys
C22F 1/183 (20130101)

Optical Elements, Systems, or Apparatus
G02B 7/003 (20130101)
G02B 7/028 (20130101) Original (OR) Class
G02B 23/2407 (20130101)
G02B 27/0012 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011646 Semmlinger et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Defense Threat Reduction Agency (DTRA)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) William Marsh Rice University (Houston, Texas);  Academia Sinica (Taipei, Taiwan)
ASSIGNEE(S) William Marsh Rice University (Houston, Texas);  Academia Sinica (Taipei, Taiwan)
INVENTOR(S) Michael Semmlinger (Houston, Texas);  Ming Lun Tseng (Taipei, Taiwan);  Jian Yang (Houston, Texas);  Ming Zhang (Houston, Texas);  Din Ping Tsai (Taipei, Taiwan);  Liangliang Dong (Houston, Texas);  Arash Ahmadivand (Houston, Texas);  Peter Nordlander (Houston, Texas);  Nancy Jean Halas (Houston, Texas)
ABSTRACT A harmonic light-generating metasurface includes a base substrate and a plurality of structures, that include nonlinear material, that are disposed in a pattern on a surface of the base substrate. Each structure of the plurality of structures individually supports a magnetic dipole mode. An electromagnetic field enhancement of the magnetic dipole mode induces generation of a harmonic signal by the plurality of structures. Alternatively, a harmonic light-generating metasurface, includes a base substrate, a supporting substrate that includes a nonlinear material, and a plurality of paired structures disposed in a pattern on a surface of the supporting substrate. Each paired structure, of the plurality of paired structures, collectively supports a toroidal dipole mode. An electromagnetic field enhancement of the toroidal dipole mode penetrates the supporting substrate to induce generation of a harmonic signal by the supporting substrate.
FILED Tuesday, October 01, 2019
APPL NO 17/281814
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/37 (20130101) Original (OR) Class
G02F 1/354 (20210101)
G02F 2202/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011664 Talapin et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Dmitri V. Talapin (La Grange Park, Illinois);  Yuanyuan Wang (Nanjing, China PRC);  Jia-Ahn Pan (Chicago, Illinois);  Haoqi Wu (Chicago, Illinois)
ABSTRACT Ligand-capped inorganic particles, dispersions of the ligand-capped inorganic particles, and films composed of the ligand-capped inorganic particles are provided. Also provided are methods of patterning the films and electronic, photonic, and optoelectronic devices that incorporate the films. The ligands include bifunctional ligands and two-component ligand systems that include a photosensitive group, cation, or molecule.
FILED Friday, October 11, 2019
APPL NO 17/283457
CURRENT CPC
Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor;
G03F 7/008 (20130101)
G03F 7/20 (20130101)
G03F 7/32 (20130101)
G03F 7/0045 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012850 Ozcan et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Aydogan Ozcan (Los Angeles, California);  Yair Rivenson (Los Angeles, California);  Yichen Wu (Los Angeles, California)
ABSTRACT A trained deep neural network transforms an image of a sample obtained with a holographic microscope to an image that substantially resembles a microscopy image obtained with a microscope having a different microscopy image modality. Examples of different imaging modalities include bright-field, fluorescence, and dark-field. For bright-field applications, deep learning brings bright-field microscopy contrast to holographic images of a sample, bridging the volumetric imaging capability of holography with the speckle-free and artifact-free image contrast of bright-field microscopy. Holographic microscopy images obtained with a holographic microscope are input into a trained deep neural network to perform cross-modality image transformation from a digitally back-propagated hologram corresponding to a particular depth within a sample volume into an image that substantially resembles a microscopy image of the sample obtained at the same particular depth with a microscope having the different microscopy image modality.
FILED Thursday, November 14, 2019
APPL NO 17/294384
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 21/0008 (20130101)
G02B 21/365 (20130101)

Holographic Processes or Apparatus
G03H 1/0005 (20130101)
G03H 1/268 (20130101)
G03H 2001/005 (20130101)

Image Data Processing or Generation, in General
G06T 5/002 (20130101) Original (OR) Class
G06T 7/50 (20170101)
G06T 2207/10056 (20130101)
G06T 2207/10064 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012890 Wu et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) University of Iowa Research Foundation (Iowa City, Iowa)
ASSIGNEE(S) University of Iowa Research Foundation (Iowa City, Iowa)
INVENTOR(S) Xiaodong Wu (Iowa City, Iowa);  Leixin Zhou (Iowa City, Iowa);  John M Buatti (Iowa City, Iowa);  Hui Xie (North Liberty, Iowa)
ABSTRACT An automated method for segmentation includes steps of receiving at a computing device an input image representing at least one surface and performing by the computing device image segmentation on the input image based on a graph surface segmentation model with deep learning. The deep learning may be used to parameterize the graph surface segmentation model.
FILED Thursday, July 01, 2021
APPL NO 17/365572
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/11 (20170101) Original (OR) Class
G06T 7/0012 (20130101)
G06T 7/162 (20170101)
G06T 2207/10072 (20130101)
G06T 2207/10132 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012901 Sun et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) University of South Florida (Tampa, Florida)
ASSIGNEE(S) University of South Florida (Tampa, Florida)
INVENTOR(S) Yu Sun (Tampa, Florida);  David Andres Paulius (Tampa, Florida);  Maxat Alibayev (Tampa, Florida)
ABSTRACT A method for motion recognition and embedding is disclosed. The method may include receiving a plurality of frames of an input video for extracting a feature vector of a motion in the plurality of frames, generating a plurality of sets of one or more motion component bits based on the feature vector and a plurality of classifiers, the plurality of sets corresponding to the plurality of classifiers, each set of one or more motion component bits representing a physical or mechanical attribute of the motion; and generating a motion code for a machine to execute the motion by combining the plurality of sets of one or more motion component bits. Other aspects, embodiments, and features are also claimed and described.
FILED Monday, July 12, 2021
APPL NO 17/373276
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00718 (20130101)
G06K 9/00744 (20130101)

Image Data Processing or Generation, in General
G06T 7/248 (20170101) Original (OR) Class
G06T 2207/10016 (20130101)
G06T 2207/30241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012923 LEBECK et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Kiron LEBECK (Seattle, Washington);  Tadayoshi KOHNO (Seattle, Washington);  Franziska ROESNER (Seattle, Washington)
ABSTRACT In some embodiments, an augmented reality system is provided. The augmented reality system is configured to detect real-world objects, create software objects that represent the real-world objects, receive requests from applications to present virtual objects at locations associated with the real-world objects, and to present the virtual objects. In some embodiments, an operating system of the augmented reality system is configured to resolve conflicts between requests from multiple applications. In some embodiments, the operating system of the augmented reality system is configured to provide information to applications to allow the applications to avoid or resolve conflicts amongst themselves.
FILED Wednesday, December 11, 2019
APPL NO 17/413516
CURRENT CPC
Image Data Processing or Generation, in General
G06T 11/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013247 Watkins et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S) University of Massachusetts (Boston, Massachusetts)
INVENTOR(S) James Watkins (South Hadley, Massachusetts);  Michael R. Beaulieu (Chicopee, Massachusetts);  Nicholas R. Hendricks (South Deerfield, Massachusetts)
ABSTRACT Aspects relate to patterned nanostructures having a feature size not including film thickness of below 5 microns. The patterned nanostructures are made up of nanoparticles having an average particle size of less than 100 nm. A nanoparticle composition, which, in some cases, includes a binder, is applied to a substrate. A patterned mold used in concert with electromagnetic radiation function to manipulate the nanoparticle composition in forming the patterned nanostructure. In some embodiments, the patterned mold nanoimprints a pattern onto the nanoparticle composition and the composition is cured through UV or thermal energy, Three-dimensional patterned nanostructures may be formed. A number of patterned nanostructure layers may be prepared and joined together. In some cases, a patterned nanostructure may be formed as a layer that is releasable from the substrate upon which it is initially formed. Such releasable layers may be arranged to form a three-dimensional patterned nanostructure for suitable applications.
FILED Friday, September 24, 2021
APPL NO 17/485281
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 30/00 (20130101)

Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties
H01B 1/08 (20130101) Original (OR) Class
H01B 3/10 (20130101)
H01B 13/003 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/0015 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/04 (20130101)
H01M 6/40 (20130101)
H01M 8/124 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013324 FAN
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
INVENTOR(S) Qi Hua FAN (Okemos, Michigan)
ABSTRACT A single beam plasma or ion source apparatus, including multiple and different power sources, is provided. An aspect of the present apparatus and method employs simultaneous excitation of an ion source by DC and AC, or DC and RF power supplies. Another aspect employs an ion source including multiple magnets and magnetic shunts arranged in a generally E cross-sectional shape.
FILED Thursday, September 23, 2021
APPL NO 17/482833
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/35 (20130101)
C23C 14/46 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 37/08 (20130101) Original (OR) Class
H01J 2237/0815 (20130101)
H01J 2237/3146 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013349 JARROLD et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana)
ASSIGNEE(S)
INVENTOR(S) Martin F. JARROLD (Bloomington, Indiana);  Aaron R. TODD (Bloomington, Indiana)
ABSTRACT An orbitrap may include elongated inner and outer electrodes, wherein the inner and outer electrodes each define two axially spaced apart electrode halves with a central transverse plane extending through the electrodes also passing between both sets of electrode halves, a cavity defined radially about and axially along the inner electrode between the two inner electrode halves and the two outer electrode halves, means for establishing an electric field configured to trap an ion in the cavity and to cause the trapped ion to rotate about, and oscillate axially along, the inner electrode, wherein the rotating and oscillating ion induces charges on the inner and outer electrode halves, and charge detection circuitry configured to detect the charges induced on the inner and on outer electrode halves, and to combine the detected charges for each oscillation to produce a measured ion charge signal.
FILED Friday, January 11, 2019
APPL NO 17/293850
CURRENT CPC
Electric Discharge Tubes or Discharge Lamps
H01J 49/425 (20130101) Original (OR) Class
H01J 49/4255 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013350 JARROLD et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana)
ASSIGNEE(S)
INVENTOR(S) Martin F. JARROLD (Bloomington, Indiana);  Daniel BOTAMANENKO (Bloomington, Indiana)
ABSTRACT A charge detection mass spectrometer may include an ion source, an electrostatic linear ion trap (ELIT) including a charge detection cylinder disposed between a pair of coaxially aligned ion mirrors, means for selectively establishing electric fields within the ion mirrors configured to cause the trapped ions in the ELIT to oscillate back and forth between the ion mirrors each time passing through the charge detection cylinder, and means for controlling a trajectory of the beam of ions entering the ELIT to cause the subsequently trapped ions to oscillate with different planar ion oscillation trajectories angularly offset from one another about the longitudinal axis with each extending along and crossing the longitudinal axis in each of the ion mirrors or with different cylindrical ion oscillation trajectories radially offset from one another about the longitudinal axis to form nested cylindrical trajectories each extending along the longitudinal axis.
FILED Friday, January 11, 2019
APPL NO 17/293852
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/623 (20210101)

Electric Discharge Tubes or Discharge Lamps
H01J 49/022 (20130101)
H01J 49/025 (20130101)
H01J 49/426 (20130101)
H01J 49/4245 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013417 Sreenivasan et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Sidlgata V. Sreenivasan (Austin, Texas);  Shrawan Singhal (Austin, Texas);  Lawrence R. Dunn (Austin, Texas)
ABSTRACT Various embodiments of the present technology generally relate to substrate planarization. More specifically, some embodiments of the present technology relate a versatile systems and methods for precision surface topography optimization known as planarization on nominally planar substrates. In some embodiments, a method for planarization of a patterned substrate using inkjets can determine the global and nanoscale topography and pattern information of the patterned substrate. Based upon the global and nanoscale topography and pattern information, a drop pattern can be determined and then dispensed on the patterned substrate. A gap between the patterned substrate and a superstrate causing the dispensed drops can be closed to form a substantially contiguous film. The substantially contiguous film can be cured and the superstrate can be separated from the patterned substrate with substantially contiguous film on the patterned substrate.
FILED Friday, December 13, 2019
APPL NO 17/413523
CURRENT CPC
Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor;
G03F 7/0002 (20130101)
G03F 7/16 (20130101)

Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 13/042 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/31051 (20130101)
H01L 22/12 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013765 Weng et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Guoming Weng (Guangdong, China PRC);  Hang Wang (Brooklyn, New York);  André D. Taylor (Brooklyn, New York)
ABSTRACT A composition comprising a graphitic carbon nitride material and a conductive carbon material coating may be used in electrodes or in batteries such as sodium ion batteries. The composition may be prepared using a method comprising the steps of providing a nitrogenous compound; adding a carbonaceous material to the nitrogenous compound to form a slurry; drying the slurry to form a coated mixture; and carbonizing the coated mixture.
FILED Friday, July 09, 2021
APPL NO 17/371613
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 21/0605 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/133 (20130101) Original (OR) Class
H01M 4/1393 (20130101)
H01M 10/054 (20130101)
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013807 Li et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) Xiaowei Li (Philadelphia, Pennsylvania);  Yongwei Zheng (Philadelphia, Pennsylvania);  Christopher Li (Bala Cynwyd, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Xiaowei Li (Philadelphia, Pennsylvania);  Yongwei Zheng (Philadelphia, Pennsylvania);  Christopher Li (Bala Cynwyd, Pennsylvania)
ABSTRACT Ionic liquid N-methyl-N-propyl-pyrrolidinium bis(fluorosulfonyl)imide (Pyr13FSI) was introduced into a hybrid network to obtain a series of gel polymer electrolytes (GPEs). Mechanical and electrochemical properties of the GPEs were tuned through controlling the network structure and ionic liquid contents, and ionic conductivity higher than 1 mS cm−1 at room temperature was achieved. The newly developed GPEs are flame-retardant and show excellent thermal and electrochemical stability as well as ultra-stability with lithium metal anode. Symmetrical lithium cells with the GPEs exhibit a stable cycling over 6800 h at a current density of 0.1 mA cm−2 and stable lithium stripping-plating at 1 mA cm−2, the highest current density reported for ionic liquid-based GPEs. Moreover, Li/LiFePO4 batteries with the obtained GPEs exhibit desirable cycling stability and rate performance over a wide temperature range from 0° C. to 90° C.
FILED Sunday, May 02, 2021
APPL NO 17/246681
CURRENT CPC
Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 65/336 (20130101)
C08G 2220/00 (20130101)
C08G 2650/20 (20130101)
C08G 2650/50 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/0525 (20130101)
H01M 10/0565 (20130101) Original (OR) Class
H01M 10/0567 (20130101)
H01M 10/4235 (20130101)
H01M 2004/027 (20130101)
H01M 2300/0085 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220014158 Bameri et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Hadi Bameri (Davis, California);  Omeed Momeni (Davis, California)
ABSTRACT A power amplifier (amp) is disclosed. This power amp can include a first transistor configured in the common source (CS) amplification mode, wherein the gate terminal of the first transistor is used as the input port of the power amp; and a second transistor configured in the common gate (CG) amplification mode, wherein the drain terminal of the second transistor is used as the output port of the power amp. The power amp also includes a first inductive component coupled between the drain terminal of the first transistor and the ground to increase the impedance between the drain terminal of the first transistor and the ground, thereby increasing an output power at the output port. The power amp additionally includes a second inductive component coupled between the drain terminal of the first transistor and the source terminal of the second transistor to increase the conductance in the output admittance at the output port, thereby further increasing the output power at the output port.
FILED Wednesday, July 07, 2021
APPL NO 17/369879
CURRENT CPC
Amplifiers
H03F 3/211 (20130101) Original (OR) Class
H03F 2200/451 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220014764 Mazumdar et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S) University of Washington (Seattle, Washington)
INVENTOR(S) Amrita Mazumdar (Seattle, Washington);  Luis Ceze (Seattle, Washington);  Mark H. Oskin (Seattle, Washington)
ABSTRACT Examples of systems and methods described herein may provide saliency-based video compression. A saliency map associated with a video may be generated and/or provided. A tile configuration may be selected for the video and quality settings assigned to each tile in accordance with the saliency map. The video may then be compressed (e.g., encoded) in tiles in accordance with the quality settings. Compressed videos may be stored together with saliency metadata, facilitating storage management and/or re-compression.
FILED Tuesday, August 06, 2019
APPL NO 17/281915
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/036 (20130101)
G06K 9/00765 (20130101)
G06K 9/4671 (20130101)

Pictorial Communication, e.g Television
H04N 19/40 (20141101)
H04N 19/115 (20141101)
H04N 19/119 (20141101)
H04N 19/176 (20141101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 20220008380 Jacobson et al.
FUNDED BY
Department of Energy (DOE)
UT-Battelle, LLC (UT-BATTELLE)
Oak Ridge National Laboratory (ORNL)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Daniel A. Jacobson (Oak Ridge, Tennessee);  Erica Teixeira Prates (Oak Ridge, Tennessee);  John I. Miller (Oak Ridge, Tennessee);  Michael R. Garvin (Oak Ridge, Tennessee)
ABSTRACT This disclosure provides methods for treating a SARS-CoV-2 infection in a subject comprising administering to the subject an effective amount of an inhibitor of COVID-induced RAS imbalance, that downregulates, for example, the Bradykinin system, the Renin-Angiotensin system, the hyaluronan synthesis pathway, or the fibrinogenesis pathway.
FILED Wednesday, July 07, 2021
APPL NO 17/368911
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/58 (20130101)
A61K 31/59 (20130101)
A61K 31/352 (20130101) Original (OR) Class
A61K 38/08 (20130101)
A61K 38/2292 (20130101)
A61K 45/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008898 BECKHAM et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Alliance for Sustainable Energy, LLC (ASE)
National Renewable Energy Laboratory (NREL)
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Gregg Tyler BECKHAM (Golden, Colorado);  Lucas Delano ELLIS (Boulder, Colorado)
ABSTRACT The present disclosure relates to a composition that includes a dehydrogenation (D) catalyst and a cross metathesis (CM) catalyst, where both catalysts are positioned on a support.
FILED Thursday, July 08, 2021
APPL NO 17/370244
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 6/001 (20130101)
B01J 21/04 (20130101)
B01J 23/42 (20130101) Original (OR) Class
B01J 37/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009124 Xiao et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Office of Fossil Energy and Carbon Management (FE)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Clemson University Research Foundation (Clemson, South Carolina)
ASSIGNEE(S)
INVENTOR(S) Hai Xiao (Clemson, South Carolina);  Jianhua Tong (Central, South Carolina);  Fei Peng (Clemson, South Carolina);  Kyle S. Brinkman (Clemson, South Carolina);  Shenglong Mu (Clemson, South Carolina);  Jincheng Lei (Clemson, South Carolina);  Yuzhe Hong (Clemson, South Carolina);  Hua Huang (Clemson, South Carolina);  Rajendra Bordia (Seneca, South Carolina)
ABSTRACT A method for fabricating a protonic ceramic energy device includes: coating an electrolyte layer on an anode layer; and densifying the electrolyte layer by a rapid laser reactive sintering (RLRS) process on the electrolyte layer and/or the anode layer to form a half-cell comprising a dense electrolyte and a porous anode.
FILED Wednesday, December 30, 2020
APPL NO 17/138173
CURRENT CPC
Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam
B23K 26/402 (20130101)
B23K 2103/52 (20180801)

Shaping Clay or Other Ceramic Compositions; Shaping Slag; Shaping Mixtures Containing Cementitious Material, e.g Plaster
B28B 1/001 (20130101) Original (OR) Class

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 40/20 (20200101)

Manufacture, Shaping, or Supplementary Processes
C03B 19/01 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009813 Kostecki et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Berkeley National Laboratory (LBNL)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Robert Kostecki (Lafayette, California);  Ravi S. Prasher (Danville, California);  Akanksha K. Menon (Berkeley, California);  Andrew Z. Haddad (Berkeley, California);  Jeffrey J. Urban (Emeryville, California)
ABSTRACT This disclosure provides systems, methods, and apparatus related to water desalination. In one aspect, a method includes generating a diluted draw solution using forward osmosis. Wastewater is on a first side of an osmotic membrane and a draw solution is on a second side of the osmotic membrane. The draw solution comprises a mixture of water and an ionic liquid. Water in the wastewater diffuses across the osmotic membrane to the draw solution to form the diluted draw solution. The diluted draw solution is heated using a photonic heater to a temperature above a lower critical solution temperature (LCST) of the ionic liquid to phase separate the diluted draw solution into the ionic liquid and treated water.
FILED Thursday, July 08, 2021
APPL NO 17/370379
CURRENT CPC
Separation
B01D 61/04 (20130101)
B01D 61/005 (20130101)
B01D 61/027 (20130101)
B01D 61/58 (20130101)

Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/445 (20130101)
C02F 9/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010137 Naskar et al.
FUNDED BY
Department of Energy (DOE)
UT-Battelle, LLC (UT-BATTELLE)
Oak Ridge National Laboratory (ORNL)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
INVENTOR(S) Amit K. Naskar (Knoxville, Tennessee);  Ngoc A. Nguyen (Oak Ridge, Tennessee)
ABSTRACT A solid polymer blend material comprising: (i) a lignin-acrylonitrile component containing a homogeneous blend of a lignin component and an acrylonitrile-containing rubber component; and (ii) a styrene-containing thermoplastic component that is non-elastomeric; wherein components (i) and (ii) are homogeneously dispersed in the polymer blend material. Methods for producing the blend material are also described. Methods for producing objects made of the blend material by melt extrusion are also described, comprising: (a) melt blending components (i) and (ii) to form a polymer blend in which components (i) and (ii) are homogeneously blended, wherein the polymer blend exhibits a melt viscosity of no more than 2000 Pa·s at a shear rate of 100-1000 s−1 and when heated to a temperature of no more than 240° C.; and (b) forming an object made of said polymer blend material.
FILED Tuesday, September 28, 2021
APPL NO 17/487061
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/106 (20170801)
B29C 64/118 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 70/00 (20141201)

Derivatives of Natural Macromolecular Compounds
C08H 6/00 (20130101)

Compositions of Macromolecular Compounds
C08L 9/02 (20130101)
C08L 25/06 (20130101)
C08L 25/14 (20130101)
C08L 55/02 (20130101)
C08L 97/005 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010429 Yacout et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Abdellatif M. Yacout (Naperville, Illinois);  Sumit Bhattacharya (Darien, Illinois);  Yinbin Miao (Naperville, Illinois);  Nicolas E. Stauff (Oak Park, Illinois)
ABSTRACT Provided herein is a hydrogen permeation barrier coating, a coated substrate, and methods of coating a substrate.
FILED Friday, July 10, 2020
APPL NO 16/925782
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 16/06 (20130101)
C23C 16/403 (20130101)
C23C 16/45529 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010437 Kuhl et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Berkeley National Laboratory (LBNL)
APPLICANT(S) Opus 12 Incorporated (Berkeley, California);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Kendra P. Kuhl (Oakland, California);  Etosha R. Cave (Berkeley, California);  George Leonard (Oakland, California)
ABSTRACT A platform technology that uses a novel membrane electrode assembly including a cathode layer comprising a reduction catalyst and a first anion-and-cation-conducting polymer, an anode layer comprising an oxidation catalyst and a cation-conducting polymer, a membrane layer comprising a cation-conducting polymer, the membrane layer arranged between the cathode layer and the anode layer and conductively connecting the cathode layer and the anode layer, in a COx reduction reactor has been developed. The reactor can be used to synthesize a broad range of carbon-based compounds from carbon dioxide.
FILED Thursday, July 08, 2021
APPL NO 17/369952
CURRENT CPC
Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 3/25 (20210101)
C25B 9/23 (20210101) Original (OR) Class
C25B 11/051 (20210101)
C25B 11/057 (20210101)
C25B 13/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010623 Su et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
National Technology and Engineering Solutions of Sandia, LLC (NTESS)
Sandia National Laboratories (SNL)
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Jiann-Cherng Su (Albuquerque, New Mexico);  Somuri V. Prasad (Albuquerque, New Mexico);  Rand Garfield (Corrales, New Mexico)
ABSTRACT A coating architecture is disclosed that includes a substrate having a surface finish Ra of 0.3μ or finer, an intermediate layer overlying and in contact with the substrate; and a solid lubricant layer overlying and in contact with the intermediate layer. The test results of applying the coating architecture to a reciprocating hammer drill utilizing the coating is also disclosed.
FILED Monday, September 27, 2021
APPL NO 17/485749
CURRENT CPC
Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form
B32B 9/007 (20130101)
B32B 15/18 (20130101)
B32B 2311/18 (20130101)
B32B 2313/04 (20130101)
B32B 2315/02 (20130101)

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 4/003 (20130101) Original (OR) Class
E21B 4/14 (20130101)
E21B 17/1007 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010662 Guyer et al.
FUNDED BY
Department of Energy (DOE)
Los Alamos National Laboratory (LANL)
National Nuclear Security Administration (NNSA)
Triad National Security, LLC (Triad)
APPLICANT(S) Chevron U.S.A. Inc. (San Ramon, California);  Triad National Security, LLC (Los Alamos, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Robert A. Guyer (Los Alamos, New Mexico);  Timothy James Ulrich, II (Los Alamos, New Mexico);  James A. Ten Cate (Los Alamos, New Mexico);  Harvey Edwin Goodman (Houston, Texas)
ABSTRACT Strain information may define strain of a material to stress. The strain of the material may be decomposed into classical strain, hysteretic strain, and residual strain. The classical strain, the hysteretic strain, and the residual strain may be used to facilitate modeling of the material. For example, the classical strain, the hysteretic strain, and the residual strain of a rock may be used to facilitate modeling of a subsurface region that includes the rock such as a reservoir simulation to predict hydrocarbon recovery.
FILED Friday, July 09, 2021
APPL NO 17/371566
CURRENT CPC
Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 43/16 (20130101) Original (OR) Class

Electric Digital Data Processing
G06F 30/20 (20200101)
G06F 2111/10 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010684 BALDWIN et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) Donald Joseph BALDWIN (Galway, New York);  Joshua Lee MARGOLIES (Niskayuna, New York);  Jacob John Kittleson (Greenville, South Carolina)
ABSTRACT A method of protecting a gas turbine component for operation in a high temperature environment that includes the gas turbine component including a substrate having a silicon-containing layer, wherein the gas turbine component has a curved surface; forming a flexible mask configured to cover the curved surface of the gas turbine component, the flexible mask including a plurality of slots disposed in a pattern; disposing the flexible mask in direct contact with the curved surface of the gas turbine component; applying a bondcoat onto the flexible mask and the gas turbine component, such that bondcoat fills the plurality of slots and contacts the curved surface; and removing the flexible mask by heat or chemical reaction, such that, after removing the flexible mask, the curved surface of the gas turbine component comprises a patterned bondcoat layer in the pattern defined by the flexible mask.
FILED Monday, September 27, 2021
APPL NO 17/485732
CURRENT CPC
Spraying Apparatus; Atomising Apparatus; Nozzles
B05B 12/20 (20180201)

Processes for Applying Fluent Materials to Surfaces, in General
B05D 1/322 (20130101)
B05D 3/12 (20130101)

Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 41/009 (20130101)
C04B 41/52 (20130101)
C04B 41/89 (20130101)

Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 5/288 (20130101) Original (OR) Class

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2220/32 (20130101)
F05D 2300/611 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010833 RIOT et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Vincent RIOT (Oakland, California);  Darrell CARTER (Livermore, California);  Todd Alan DECKER (Grants Pass, Oregon)
ABSTRACT The present disclosure relates to a reduced friction torsion component system that makes use of a first frame portion adapted to be coupled to, or integrally formed with, a first object, and forming a first bore, and a second frame portion adapted to be coupled to, or integrally formed with, a second object, and forming a second bore. The two bores are axially aligned and receive at least one elongated hinge component. The elongated hinge component operates to both couple the first and second frame portions together for pivoting movement relative to one another, and also provides a torsional biasing force to enable pivotal deployment from a first position to a second position of one of the first or second frame portions.
FILED Monday, July 13, 2020
APPL NO 16/927235
CURRENT CPC
Cosmonautics; Vehicles or Equipment Therefor
B64G 1/443 (20130101)

Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for
F03G 7/065 (20130101)

Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings
F16C 11/12 (20130101) Original (OR) Class
F16C 2202/28 (20130101)
F16C 2204/42 (20130101)
F16C 2204/52 (20130101)
F16C 2226/00 (20130101)
F16C 2226/60 (20130101)
F16C 2229/00 (20130101)
F16C 2240/70 (20130101)
F16C 2326/47 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010929 Miao et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Yinbin Miao (Naperville, Illinois);  Nicolas E. Stauff (Oak Park, Illinois);  Sumit Bhattacharya (Darien, Illinois);  Abdellatif M. Yacout (Naperville, Illinois);  Taek K. Kim (Naperville, Illinois)
ABSTRACT A gas enclosure of can include a refractory metal liner adapted to surround and enclose a gas to be contained; a ceramic matrix composite cladding; and a diffusion barrier layer disposed between the refractory metal liner and the ceramic matrix composite cladding.
FILED Friday, July 10, 2020
APPL NO 16/925839
CURRENT CPC
Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases
F17C 1/10 (20130101) Original (OR) Class
F17C 1/14 (20130101)
F17C 2203/0604 (20130101)
F17C 2203/0607 (20130101)
F17C 2203/0639 (20130101)
F17C 2203/0646 (20130101)
F17C 2203/0648 (20130101)
F17C 2209/225 (20130101)
F17C 2221/011 (20130101)
F17C 2221/012 (20130101)
F17C 2221/017 (20130101)
F17C 2260/053 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011188 Kotovsky et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Jack Kotovsky (Alameda, California);  Taylor Bevis (Bothell, Washington)
ABSTRACT Measurement of pressure of a fluid in a vessel using a cantilever spring in the vessel; a magnet connected to the cantilever spring in the vessel; an electromagnet outside of the vessel operatively connected to the magnet and the cantilever spring in the vessel, wherein the electromagnet induces movement of the magnet and the cantilever spring in the vessel, and wherein the movement is related to the pressure of the fluid in the vessel; a receiving coil operatively positioned relative to the magnet, wherein movement of the cantilever spring and the magnet in the vessel creates an electromotive response in the coil; and a controller analyzer connected to the receiving coil, wherein the controller analyzer uses the electromotive response in the coil for measuring the pressure of the fluid in the vessel.
FILED Tuesday, September 28, 2021
APPL NO 17/449168
CURRENT CPC
Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure
G01L 9/02 (20130101)
G01L 9/007 (20130101)
G01L 9/10 (20130101)
G01L 9/12 (20130101)
G01L 9/14 (20130101) Original (OR) Class
G01L 9/0051 (20130101)
G01L 9/0072 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011249 Yao et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Berkeley National Laboratory (LBNL)
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Norman Ying Yao (Berkeley, California);  Raymond Jeanloz (Berkeley, California);  Thomas Mittiga (Berkeley, California);  Prabudhya Bhattacharyya (Berkeley, California);  Thomas J. Smart (Berkeley, California);  Francisco Machado (Berkeley, California);  Bryce Kobrin (Berkeley, California);  Soonwon Choi (Berkeley, California);  Joel Moore (Berkeley, California);  Satcher Hsieh (Berkeley, California);  Chong Zu (Berkeley, California)
ABSTRACT A pressure chamber has a chamber wall. The chamber wall includes a sensor integrated within the chamber wall, wherein the sensor integrated in the chamber wall comprises defects. A method of determining an effect of pressure on a material is further described. The method includes applying pressure to a material within a pressure chamber and to a pressure chamber wall of the pressure chamber, where the pressure chamber wall has defects. A signal from the defects is sensed while the material and the pressure chamber wall are under pressure. A property of the material is determined based on the sensed signal.
FILED Thursday, December 19, 2019
APPL NO 17/312893
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 32/28 (20170801)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 3/12 (20130101)
G01N 23/20041 (20130101) Original (OR) Class
G01N 2203/0488 (20130101)

Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/46 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011512 Ramachandran et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) Trustees of Boston University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Siddharth Ramachandran (Boston, Massachusetts);  Zelin Ma (Boston, Massachusetts)
ABSTRACT An optical fiber system exploits a principle of topological confinement for guided higher-order modes, in contrast to more conventional total-internal-reflection (TIR) confinement. The optical fiber has a geometry and index profile defining a cutoff wavelength for a predetermined L-mode of optical signal propagation in the optical fiber, where L is azimuthal mode index. An optical source subsystem is coupled to the optical fiber to establish an optical signal propagating in the optical fiber, wherein the optical signal has the predetermined L-mode and a wavelength being either (1) at least 15% above the cutoff wavelength such that the optical beam propagates as a topologically confined mode, or (2) sufficiently above the cutoff wavelength that, based on the L-mode of the optical beam, the optical beam propagates as a topologically confined mode having propagation loss less than 3 dB/meter.
FILED Sunday, May 09, 2021
APPL NO 17/315314
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 6/14 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011535 Monroe et al.
FUNDED BY
Department of Energy (DOE)
Basic Energy Sciences (BES)
Los Alamos National Laboratory (LANL)
Los Alamos National Security, LLC (LANS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) James Alan Monroe (College Station, Texas);  David Scott Content (Spring, Texas);  Jeremy Sean McAllister (Bryan, Texas);  Jay Russell Zgarba (Sugar Land, Texas)
ASSIGNEE(S)
INVENTOR(S) James Alan Monroe (College Station, Texas);  David Scott Content (Spring, Texas);  Jeremy Sean McAllister (Bryan, Texas);  Jay Russell Zgarba (Sugar Land, Texas)
ABSTRACT A lens alignment system and method is disclosed. The disclosed system/method integrates one or more lens retaining members/tubes (LRM/LRT) and focal length spacers (FLS) each comprising a metallic material product (MMP) specifically manufactured to have a thermal expansion coefficient (TEC) in a predetermined range via selection of the individual MMP materials and an associated MMP manufacturing process providing for controlled TEC. This controlled LRM/LRT TEC enables a plurality of optical lenses (POL) fixed along a common optical axis (COA) by the LRM/LRT to maintain precise interspatial alignment characteristics that ensure consistent and/or controlled series focal length (SFL) within the POL to generate a thermally neutral optical system (TNOS). Integration of the POL using this LRM/LRT/FLS lens alignment system reduces the overall TNOS implementation cost, reduces the overall TNOS mass, reduces TNOS parts component count, and increases the reliability of the overall optical system.
FILED Tuesday, September 07, 2021
APPL NO 17/467719
CURRENT CPC
Alloys
C22C 14/00 (20130101)

Changing the Physical Structure of Non-ferrous Metals and Non-ferrous Alloys
C22F 1/183 (20130101)

Optical Elements, Systems, or Apparatus
G02B 7/003 (20130101)
G02B 7/028 (20130101) Original (OR) Class
G02B 23/2407 (20130101)
G02B 27/0012 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220011742 Shusteff et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Livermore National Laboratory (LLNL)
Lawrence Livermore National Security LLC (LLNS)
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Maxim Shusteff (Piedmont, California);  Kyle Champley (Pleasanton, California);  Erika Jo Fong (San Ramon, California);  Hayden Taylor (Berkeley, California);  Chi Chung Li (Berkeley, California);  Trevor Rongey, JR. (Livermore, California);  Sui Man Luk (Berkeley, California);  Heting Fu (Berkeley, California);  Samira Feili (Berkeley, California);  Joseph Toombs (Berkeley, California);  Hossein Heidari (Berkeley, California)
ABSTRACT A system for determining a light intensity field for use in manufacturing a 3D object from a volume of material. The system receives a 3D specification of a 3D geometry for the 3D object that specifies voxels within the volume that contain material that is to be part of the 3D object. The system employs a cost function for effectiveness of a light intensity field in manufacturing the 3D object. The cost function may be an adjoint of an Attenuated Radon Transform that models an energy dose that each voxel would receive during manufacture of the 3D object using the light intensity field. The system applies an optimization technique that employs the cost function to generate a measure of the effectiveness of possible light intensity fields and outputs an indication of a light intensity field that will be effective in manufacturing the 3D object.
FILED Monday, July 13, 2020
APPL NO 16/927469
CURRENT CPC
Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 19/4099 (20130101) Original (OR) Class
G05B 2219/49023 (20130101)

Image Data Processing or Generation, in General
G06T 7/0004 (20130101)
G06T 2207/30108 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012178 Michelogiannakis et al.
FUNDED BY
Department of Energy (DOE)
Lawrence Berkeley National Laboratory (LBNL)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Georgios Michelogiannakis (Berkeley, California);  John Shalf (Oakland, California)
ABSTRACT A last-level collective hardware prefetcher (LLCHP) is described. The LLCHP is to detect a first off-chip memory access request by a first processor core of a plurality of processor cores. The LLCHP is further to determine, based on the first off-chip memory access request, that first data associated with the first off-chip memory access request is associated with second data of a second processor core of the plurality of processor cores. The LLCHP is further to prefetch the first data and the second data based on the determination.
FILED Wednesday, November 06, 2019
APPL NO 17/295797
CURRENT CPC
Electric Digital Data Processing
G06F 12/0811 (20130101)
G06F 12/0835 (20130101)
G06F 12/0862 (20130101) Original (OR) Class
G06F 15/7825 (20130101)
G06F 2212/6026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012367 Ramanan et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Paritosh P. Ramanan (Atlanta, Georgia);  Nagi Z. Gebraeel (Marietta, Georgia)
ABSTRACT An exemplary blockchain-based decentralized computing system and method are disclosed for industrial analytics applications. The exemplary system and method leverage blockchain technology to deliver and execute privacy-preserving decentralized predictive analytics, machine learning, and optimization operations for various industrial applications using a set of self-contained analytics block smart contracts that can be readily utilized and in analytics applications to deploy across multiple sites.
FILED Friday, July 09, 2021
APPL NO 17/372064
CURRENT CPC
Electric Digital Data Processing
G06F 8/41 (20130101)
G06F 11/3688 (20130101)
G06F 16/27 (20190101)
G06F 16/2379 (20190101)
G06F 21/64 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013243 Miao et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
UChicago Argonne, LLC (UCHICAGO)
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Yinbin Miao (Naperville, Illinois);  Nicolas E. Stauff (Oak Park, Illinois);  Sumit Bhattacharya (Darien, Illinois);  Abdellatif M. Yacout (Naperville, Illinois);  Taek K. Kim (Naperville, Illinois)
ABSTRACT Provided herein is a moderation module and a thermal neutron micro-reactor.
FILED Friday, July 10, 2020
APPL NO 16/926132
CURRENT CPC
Nuclear Reactors
G21C 5/12 (20130101) Original (OR) Class
G21C 15/08 (20130101)

Nuclear Power Plant
G21D 5/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013268 GE et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Shencheng GE (Boston, Massachusetts);  George M. WHITESIDES (Newton, Massachusetts)
ABSTRACT A magnetic levitation system is described, including a first cylinder-shaped magnet; a second cylinder-shaped magnet coaxially aligned with the first cylinder-shaped magnet; and a first cavity coaxially aligned with the first cylinder-shaped magnet; wherein the surfaces of the like-poles of the first and second cylinder-shaped magnets are parallel to each other and face each other to result in a linear magnetic field between the first and the second magnets. Methods of using a magnetic levitation system for analyzing a diamagnetic or paramagnetic sample are also described.
FILED Thursday, September 26, 2019
APPL NO 17/279419
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 9/00 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 7/0236 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013671 Zhao et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Yuji Zhao (Chandler, Arizona);  Chen Yang (Tempe, Arizona);  Houqiang Fu (Tempe, Arizona);  Xuanqi Huang (Tempe, Arizona);  Kai Fu (Tempe, Arizona)
ASSIGNEE(S)
INVENTOR(S) Yuji Zhao (Chandler, Arizona);  Chen Yang (Tempe, Arizona);  Houqiang Fu (Tempe, Arizona);  Xuanqi Huang (Tempe, Arizona);  Kai Fu (Tempe, Arizona)
ABSTRACT Fabricating a vertical-channel junction field-effect transistor includes forming an unintentionally doped GaN layer on a bulk GaN layer by metalorganic chemical vapor deposition, forming a Cr/SiO2 hard mask on the unintentionally doped GaN layer, patterning a fin by electron beam lithography, defining the Cr and SiO2 hard masks by reactive ion etching, improving a regrowth surface with inductively coupled plasma etching, removing hard mask residuals, regrowing a p-GaN layer, selectively etching the p-GaN layer, forming gate electrodes by electron beam evaporation, and forming source and drain electrodes by electron beam evaporation. The resulting vertical-channel junction field-effect transistor includes a doped GaN layer, an unintentionally doped GaN layer on the doped GaN layer, and a p-GaN regrowth layer on the unintentionally doped GaN layer. Portions of the p-GaN regrowth layer are separated by a vertical channel of the unintentionally doped GaN layer.
FILED Monday, July 12, 2021
APPL NO 17/372810
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/3065 (20130101)
H01L 21/3081 (20130101)
H01L 29/1058 (20130101)
H01L 29/2003 (20130101)
H01L 29/8083 (20130101) Original (OR) Class
H01L 29/66446 (20130101)
H01L 29/66909 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013704 Chen et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Renkun Chen (San Diego, California);  Sahngki Hong (La Jolla, California)
ABSTRACT Thermoelectric devices (TE) devices may be used to power wearable electronics, such as watches and sensors by harvesting heat from the body. These TE devices may fully power or partially power the wearable devices to extend a usage time, or to recharge a battery. In other example embodiments, TE devices can be used to provide heating and/or cooling. The TE devices can be integrated into garments such as clothes, vests, and armbands for outdoor and indoor environments. For outdoor environments, applications include, but are not limited to, sports such as golfing, bicycling, running, walking, training, soccer, hiking, and other outdoor activities related to occupations, such as construction, fire-fighting, military operations, law enforcement, farming, underground mining, and so on. In other example embodiments, TE devices can be used to provide thermal camouflaging for people and objects so as to not be seen by thermal imaging devices.
FILED Wednesday, November 20, 2019
APPL NO 17/295851
CURRENT CPC
Outerwear; Protective Garments; Accessories
A41D 31/04 (20190201)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 35/30 (20130101)
H01L 35/32 (20130101) Original (OR) Class
H01L 35/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013733 Li
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona)
ASSIGNEE(S)
INVENTOR(S) Jian Li (Tempe, Arizona)
ABSTRACT A white organic light emitting device comprises a first electrode; a hole transporting layer in contact with the first electrode; a second electrode; an electron transporting layer in contact with the second electrode; and an emissive layer between the hole transporting layer and the electron transporting layer. The emissive layer comprises a host, a fluorescent emitter, and a phosphorescent emitter. The fluorescent emitter harvests singlet excitons and emits blue light, and the phosphorescent emitter harvests triplet excitons and emits yellow-amber light.
FILED Tuesday, June 15, 2021
APPL NO 17/347716
CURRENT CPC
Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/06 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 51/008 (20130101)
H01L 51/0084 (20130101) Original (OR) Class
H01L 51/5056 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013787 Gleason et al.
FUNDED BY
Department of Energy (DOE)
Argonne National Laboratory (ANL)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Karen K. Gleason (Cambridge, Massachusetts);  Fikile Brushett (Cambridge, Massachusetts);  Charles Wan (Cambridge, Massachusetts);  Antoni Forner-Cuenca (Eindhoven, Netherlands);  Meysam Heydari Gharahcheshmeh (Somerville, Massachusetts);  Yasser Ashraf Gandomi (Somerville, Massachusetts)
ABSTRACT The present disclosure relates to electrodes comprising a polymer film and a substrate, wherein the polymer film has a thickness of about 5 nm to about 600 nm. The present disclosure also relates to electrochemical cells and batteries comprising the electrodes disclosed herein. The present disclosure also relates to methods of making the electrodes disclosed herein.
FILED Thursday, July 08, 2021
APPL NO 17/370611
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/366 (20130101)
H01M 4/368 (20130101)
H01M 4/0404 (20130101)
H01M 4/624 (20130101) Original (OR) Class
H01M 4/663 (20130101)
H01M 8/188 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013800 Sankarasubramanian et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S)
INVENTOR(S) Shrihari Sankarasubramanian (St. Louis, Missouri);  Vijay Ramani (St. Louis, Missouri)
ABSTRACT Described herein is a novel electrode-decoupled redox flow battery, a novel reinforced electrode-decoupled redox flow battery, and methods of using same to store energy. Advantages of these novel electrode-decoupled redox flow batteries include long life, excellent rate capability, and stability.
FILED Wednesday, July 07, 2021
APPL NO 17/305422
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/94 (20130101)
H01M 8/188 (20130101) Original (OR) Class
H01M 2300/0011 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013857 Visco et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) PolyPlus Battery Company (Berkeley, California)
ASSIGNEE(S) PolyPlus Battery Company (Berkeley, California)
INVENTOR(S) Steven J. Visco (Berkeley, California);  Yevgeniy S. Nimon (Danville, California);  Bruce D. Katz (Moraga, California)
ABSTRACT Manufacturing methods for making a substantially rectangular and flat glass preform for manufacturing a Li ion conducting glass separator can involve drawing the preform to a thin sheet and may involve one or more of slumping, rolling or casting the glass within a frame that defines a space filling region and therewith the shape and size of the preform. The thickness of the rectangular flat preform so formed may be about 2 mm or less. The frame may be slotted having a back surface and widthwise wall portion that define the height and width of the space filling region. The flat backing surface and surfaces of the widthwise wall portions are defined may be coated by a material that is inert in direct contact with the heated glass material, such as gold.
FILED Tuesday, May 04, 2021
APPL NO 17/302491
CURRENT CPC
Manufacture, Shaping, or Supplementary Processes
C03B 15/02 (20130101)
C03B 19/02 (20130101)

Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials
C03C 17/22 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/0525 (20130101)
H01M 10/0562 (20130101)
H01M 50/403 (20210101) Original (OR) Class
H01M 50/437 (20210101)
H01M 50/449 (20210101)
H01M 50/466 (20210101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220014378 Duncan et al.
FUNDED BY
Department of Energy (DOE)
UT-Battelle, LLC (UT-BATTELLE)
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Andrew M. Duncan (Oak Ridge, Tennessee);  Andrew Harter (Oak Ridge, Tennessee);  Charles K. Roberts, II (Oak Ridge, Tennessee);  Brad J. Stinson (Oak Ridge, Tennessee);  Thad Thompson (Oak Ridge, Tennessee);  Bogdan Vacaliuc (Oak Ridge, Tennessee)
ABSTRACT A multimodal communication system includes a vehicle controller that controls one or more systems or subsystems of an unmanned vehicle. The communication controller manages communication and logical access to the unmanned vehicle. One or more sensors in communication with the communication controller detects and measures physical properties in proximity to the unmanned vehicle. Transceivers receive the unmanned vehicle commands that are transmitted simultaneously or concurrently and a monotonic generator generates a monotonic object each time the unmanned vehicle's operating state changes. The communication controller executes the first unmanned vehicle command received that has the correct cryptographic hash validating knowledge of the unmanned vehicle's current operating state.
FILED Friday, April 23, 2021
APPL NO 17/239067
CURRENT CPC
Systems for Controlling or Regulating Non-electric Variables
G05D 1/0022 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/3236 (20130101) Original (OR) Class

Wireless Communication Networks
H04W 12/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 20220007939 Dave et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) PlenOptika, Inc. (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Shivang R. Dave (Boston, Massachusetts);  Daryl Lim (Singapore, Singapore);  Nicholas James Durr (Baltimore, Maryland)
ABSTRACT An apparatus, and corresponding method, for determining a property of an eye includes a housing with a proximal port that receives an eye and also light from the eye. The housing further includes a distal port, and the two ports together form a visual channel providing an open view to enable the eye to see target indicia external to and spaced away from the housing. A wavefront sensor within the housing is configured to receive the light from the eye via the optical path and to measure a wavefront of the light. A determination module determines an objective refractive correction based on the wavefront and predicts a subjective refractive preference of a person having the eye based on the objective refractive correction. Embodiments can be handheld, and binocular, and predict subjective refraction based on demographic and other information.
FILED Tuesday, July 20, 2021
APPL NO 17/380891
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 3/005 (20130101)
A61B 3/0008 (20130101)
A61B 3/09 (20130101)
A61B 3/18 (20130101) Original (OR) Class
A61B 3/028 (20130101)
A61B 3/0033 (20130101)
A61B 3/103 (20130101)
A61B 3/0285 (20130101)
A61B 3/1208 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220007943 Sanchez et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) ENSPECTRA HEALTH, INC. (Mountain View, California)
ASSIGNEE(S)
INVENTOR(S) Gabriel Sanchez (Menlo Park, California);  Fred Landavazo, IV (Redwood City, California);  Kathryn Montgomery (Mountain View, California);  Piyush Arora (San Carlos, California)
ABSTRACT Provided herein are methods, devices, and systems that may improve optical resolution when imaging through a thickness of samples. A method for generating a depth profile of a tissue of a subject may comprise using an optical probe to transmit an excitation light beam from a light source towards a surface of the tissue; using one or more focusing units in the optical probe to simultaneously adjust a depth and a position of a focal point of the excitation light beam along a scanning path; detecting at least a subset of the signals generated upon contacting the tissue with the excitation light beam; and using one or more computer processors programmed to process the at least the subset of the signals to generate the depth profile of the tissue.
FILED Tuesday, May 11, 2021
APPL NO 17/317661
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0071 (20130101)
A61B 5/0075 (20130101) Original (OR) Class
A61B 5/0084 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101)
G06T 2207/10016 (20130101)
G06T 2207/10028 (20130101)
G06T 2207/30024 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008970 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Fall River, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Jack Rowbottom (Swansea, Massachusetts);  Nicole Neff (Colorado Springs, Colorado)
ABSTRACT Systems and methods for controlling extraction of landfill gas from a landfill via a gas extraction system are provided herein. According to some aspects of the technology, there is provided site-level control methods for globally controlling one or more wells based on one or more characteristics of aggregate landfill gas collected from a plurality of wells at a gas output. According to some aspects of the technology, there is provided well-level control methods for locally controlling a first well based on or more characteristics of landfill gas collected from the first well. According to further aspects of the technology, there is provided hybrid control methods for making adjustments to a respective well based on both site-level and well-level control methods.
FILED Monday, July 13, 2020
APPL NO 16/927471
CURRENT CPC
Disposal of Solid Waste
B09B 1/006 (20130101)
B09B 3/0016 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 43/123 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008971 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Fall River, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Jack Rowbottom (Swansea, Massachusetts);  Nicole Neff (Colorado Springs, Colorado)
ABSTRACT Systems and methods for controlling extraction of landfill gas from a landfill via a gas extraction system are provided herein. According to some aspects of the technology, there is provided site-level control methods for globally controlling one or more wells based on one or more characteristics of aggregate landfill gas collected from a plurality of wells at a gas output. According to some aspects of the technology, there is provided well-level control methods for locally controlling a first well based on or more characteristics of landfill gas collected from the first well. According to further aspects of the technology, there is provided hybrid control methods for making adjustments to a respective well based on both site-level and well-level control methods.
FILED Monday, July 13, 2020
APPL NO 16/927479
CURRENT CPC
Reclamation of Contaminated Soil
B09C 1/005 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 34/00 (20130101)
E21B 47/06 (20130101)
E21B 49/0875 (20200501)

Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure
G01L 11/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/004 (20130101)
G01N 33/0044 (20130101)
G01N 33/0047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008972 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Fall River, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Jack Rowbottom (Swansea, Massachusetts);  Nicole Neff (Colorado Springs, Colorado)
ABSTRACT Systems and methods for controlling extraction of landfill gas from a landfill via a gas extraction system are provided herein. According to some aspects of the technology, there is provided site-level control methods for globally controlling one or more wells based on one or more characteristics of aggregate landfill gas collected from a plurality of wells at a gas output. According to some aspects of the technology, there is provided well-level control methods for locally controlling a first well based on or more characteristics of landfill gas collected from the first well. According to further aspects of the technology, there is provided hybrid control methods for making adjustments to a respective well based on both site-level and well-level control methods.
FILED Monday, July 13, 2020
APPL NO 16/927482
CURRENT CPC
Reclamation of Contaminated Soil
B09C 1/005 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 34/00 (20130101)
E21B 47/06 (20130101)
E21B 49/0875 (20200501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/004 (20130101)
G01N 33/0044 (20130101)
G01N 33/0047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220008973 Quigley et al.
FUNDED BY
National Science Foundation (NSF)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Fall River, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts);  Jack Rowbottom (Swansea, Massachusetts);  Nicole Neff (Colorado Springs, Colorado)
ABSTRACT Systems and methods for controlling extraction of landfill gas from a landfill via a gas extraction system are provided herein. According to some aspects of the technology, there is provided site-level control methods for globally controlling one or more wells based on one or more characteristics of aggregate landfill gas collected from a plurality of wells at a gas output. According to some aspects of the technology, there is provided well-level control methods for locally controlling a first well based on or more characteristics of landfill gas collected from the first well. According to further aspects of the technology, there is provided hybrid control methods for making adjustments to a respective well based on both site-level and well-level control methods.
FILED Monday, July 13, 2020
APPL NO 16/927488
CURRENT CPC
Reclamation of Contaminated Soil
B09C 1/005 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 34/00 (20130101)
E21B 47/06 (20130101)
E21B 49/0875 (20200501)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/004 (20130101)
G01N 33/0044 (20130101)
G01N 33/0047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220009991 Antipov et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Silver Creek Pharmaceuticals, Inc. (San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) Laura D.J. Antipov (Oakland, California);  Shawdee Eshghi (Oakland, California);  Kristopher M. Kuchenbecker (Phoenix, Arizona);  Bjorn L. Millard (Orinda, California);  Matthew D. Onsum (El Cerrito, California);  Andrea D. Nickerson (San Francisco, California);  Timothy R. Stowe (San Francisco, California);  Yan Zhang (San Francisco, California)
ABSTRACT Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue.
FILED Tuesday, September 28, 2021
APPL NO 17/487120
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/47 (20130101)
C07K 14/65 (20130101) Original (OR) Class
C07K 14/765 (20130101)
C07K 2319/035 (20130101)
C07K 2319/75 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013767 YUSHIN et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Glenn Research Center (GLENN)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Sila Nanotechnologies Inc. (Alameda, California)
ASSIGNEE(S)
INVENTOR(S) Gleb YUSHIN (Atlanta, Georgia);  Oleksandr MAGAZYNSKYY (Atlanta, Georgia);  Patrick DIXON (Dunwoody, Georgia);  Benjamin HERTZBERG (New York, New York)
ABSTRACT Described herein are improved composite anodes and lithium-ion batteries made therefrom. Further described are methods of making and using the improved anodes and batteries. In general, the anodes include a porous composite having a plurality of agglomerated nanocomposites. At least one of the plurality of agglomerated nanocomposites is formed from a dendritic particle, which is a three-dimensional, randomly-ordered assembly of nanoparticles of an electrically conducting material and a plurality of discrete non-porous nanoparticles of a non-carbon Group 4A element or mixture thereof disposed on a surface of the dendritic particle. At least one nanocomposite of the plurality of agglomerated nanocomposites has at least a portion of its dendritic particle in electrical communication with at least a portion of a dendritic particle of an adjacent nanocomposite in the plurality of agglomerated nanocomposites.
FILED Friday, September 24, 2021
APPL NO 17/484451
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/38 (20130101)
H01M 4/133 (20130101)
H01M 4/134 (20130101)
H01M 4/137 (20130101)
H01M 4/366 (20130101) Original (OR) Class
H01M 4/587 (20130101)
H01M 4/602 (20130101)
H01M 4/625 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 20220008500 Kay et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The George Washington University (Washington, District of Columbia);  The U.S. Government as represented by The Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Matthew Kay (Kensington, Maryland);  Kara Garrott (Washington, District of Columbia);  Jhansi Dyavanapalli (Gaithersburg, Maryland);  David Mendelowitz (Vienna, Virginia);  Gregory Trachiotis (Arlington, Virginia)
ABSTRACT Methods of treating a subject having heart failure including heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, and left ventricular hypertrophy-induced heart failure. The methods include activating hypothalamic oxytocin neurons in the brain of the subject and/or administering intranasally to the subject a therapeutically effective amount of oxytocin. Intranasal formulations for the treatment of a subject diagnosed with heart failure are also provided.
FILED Wednesday, June 16, 2021
APPL NO 17/349771
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0043 (20130101)
A61K 38/095 (20190101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/10 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220010269 Cullen et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Veterans Affairs (DVA)
APPLICANT(S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania);  The United States of America as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Daniel Kacy Cullen (Media, Pennsylvania);  Suradip Das (Philadelphia, Pennsylvania);  Wisberty Gordian-Velez (Philadelphia, Pennsylvania)
ABSTRACT In various aspects and embodiments, the present invention provides methods for preparing innervated tissue. In various embodiments the invention further provides innervated tissue generated using the methods described herein. In various embodiments the inclusion of optogenetically transducible TENGs or Micro-TENNs in the innervated tissue allows the modulation of tissue or organs by using light to stimulate the optogenetically transducible TENGs or Micro-TENNs.
FILED Friday, November 08, 2019
APPL NO 17/291869
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/34 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0068 (20130101) Original (OR) Class
C12N 5/0619 (20130101)
C12N 5/0633 (20130101)
C12N 5/0648 (20130101)
C12N 5/0657 (20130101)
C12N 5/0658 (20130101)
C12N 5/0677 (20130101)
C12N 5/0679 (20130101)
C12N 5/0685 (20130101)
C12N 2502/081 (20130101)
C12N 2513/00 (20130101)
C12N 2533/76 (20130101)
C12N 2533/80 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220012902 Madabhushi et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Center for Research Resources (NCRR)
National Eye Institute (NEI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Case Western Reserve University (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Anant Madabhushi (Shaker Heights, Ohio);  Jacob Antunes (Cincinnati, Ohio);  Zhouping Wei (Cleveland, Ohio);  Pallavi Tiwari (Wexford, Pennsylvania);  Satish E. Viswanath (Pepper Pike, Ohio);  Charlems Alvarez Jimenez (Bogotá, Colombia)
ABSTRACT The present disclosure, in some embodiments, relates to a non-transitory computer-readable medium storing computer-executable instructions. The computer readable medium is configured to cause a processor to access an image volume of a rectum comprising a rectal tumor. A forward mapping is generated based on non-rigidly registering a healthy rectal atlas to the image volume. The forward mapping is inverted to generate an inverse mapping from the image volume to the healthy rectal atlas. Based on the inverse mapping, a plurality of deformation vectors, associated with a deformation within a rectal wall of the rectum, are determined. Magnitude based deformation features and orientation based deformation features are computed from the plurality of deformation vectors. One or more of the magnitude based deformation features and one or more of the orientation based deformation features are utilized to determine a response of a patient to a chemoradiation treatment.
FILED Wednesday, September 22, 2021
APPL NO 17/481625
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/33 (20170101) Original (OR) Class
G06T 7/38 (20170101)
G06T 2207/10088 (20130101)
G06T 2207/30096 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/40 (20180101)
G16H 50/70 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 20220011179 RYU
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) New Mexico Tech University Research Park Corporation (Socorro, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Donghyeon RYU (Socorro, New Mexico)
ABSTRACT Disclosed herein is a composition and a method for energy harvesting and the autonomous detection of structural failure. This method can be used to monitor, for example, the structural integrity of unmanned aircraft systems.
FILED Monday, May 17, 2021
APPL NO 17/321830
CURRENT CPC
Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for
B64F 5/60 (20170101)

Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure
G01L 1/24 (20130101) Original (OR) Class

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 41/082 (20130101)
H01L 41/193 (20130101)
H01L 41/1132 (20130101)
H01L 51/004 (20130101)
H01L 51/0035 (20130101)
H01L 51/0036 (20130101)
H01L 51/0037 (20130101)
H01L 51/0047 (20130101)
H01L 51/0048 (20130101)
H01L 51/0094 (20130101)
H01L 51/5287 (20130101)

Electric Machines Not Otherwise Provided for
H02N 2/186 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013706 Greer et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Jet Propulsion Laboratory (JPL)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S) California Institute of Technology (Pasadena, California)
INVENTOR(S) Harold Frank Greer (Pasadena, California);  Andrew D. Beyer (Pasadena, California);  Matthew D. Shaw (Pasadena, California);  Daniel P. Cunnane (Pasadena, California)
ABSTRACT A method for etching a surface including obtaining a structure comprising a plurality of nanowires on or above a substrate and a dielectric layer on or above the nanowires, wherein the dielectric layer comprises protrusions formed by the underlying nanowires; reacting a surface of the dielectric layer with a reactant, comprising a gas or a plasma, to form a reactive layer on the dielectric layer, wherein the reactive layer comprises a chemical compound including the reactant and elements of the dielectric layer and the reactive layer comprises sidewalls defined by the protrusions; and selectively etching the reactive layer, wherein the etching etches the protrusions laterally through the sidewalls so as to planarize the surface and remove or shrink the protrusions.
FILED Monday, July 12, 2021
APPL NO 17/373619
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 39/08 (20130101)
H01L 39/24 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220013767 YUSHIN et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Glenn Research Center (GLENN)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Sila Nanotechnologies Inc. (Alameda, California)
ASSIGNEE(S)
INVENTOR(S) Gleb YUSHIN (Atlanta, Georgia);  Oleksandr MAGAZYNSKYY (Atlanta, Georgia);  Patrick DIXON (Dunwoody, Georgia);  Benjamin HERTZBERG (New York, New York)
ABSTRACT Described herein are improved composite anodes and lithium-ion batteries made therefrom. Further described are methods of making and using the improved anodes and batteries. In general, the anodes include a porous composite having a plurality of agglomerated nanocomposites. At least one of the plurality of agglomerated nanocomposites is formed from a dendritic particle, which is a three-dimensional, randomly-ordered assembly of nanoparticles of an electrically conducting material and a plurality of discrete non-porous nanoparticles of a non-carbon Group 4A element or mixture thereof disposed on a surface of the dendritic particle. At least one nanocomposite of the plurality of agglomerated nanocomposites has at least a portion of its dendritic particle in electrical communication with at least a portion of a dendritic particle of an adjacent nanocomposite in the plurality of agglomerated nanocomposites.
FILED Friday, September 24, 2021
APPL NO 17/484451
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/38 (20130101)
H01M 4/133 (20130101)
H01M 4/134 (20130101)
H01M 4/137 (20130101)
H01M 4/366 (20130101) Original (OR) Class
H01M 4/587 (20130101)
H01M 4/602 (20130101)
H01M 4/625 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 20220007608 Hankoua et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Bertrand B. Hankoua (Dover, Delaware);  Ayalew Ligaba Osena (Dover, Delaware)
ASSIGNEE(S) Delaware State University (Dover, Delaware)
INVENTOR(S) Bertrand B. Hankoua (Dover, Delaware);  Ayalew Ligaba Osena (Dover, Delaware)
ABSTRACT The present invention provides a longitudinally split immature tiller separated from a rhizome (LSITR), a cluster of multiple in vitro shoots (CMIT), a cluster of stem segments containing shoot primordia (CSSSP) and an in vitro tiller of Miscanthus x giganteus (Giant Miscanthus), and their uses in propagating Miscanthus x giganteus (Giant Miscanthus).
FILED Thursday, September 23, 2021
APPL NO 17/482723
CURRENT CPC
Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering
A01G 20/00 (20180201)

New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques
A01H 4/005 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220007652 SMITH et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Mississippi State University (Starkville, Mississippi);  The Texas A and M University System (College Station, Texas)
ASSIGNEE(S) Mississippi State University (Starkville, Mississippi);  The Texas A and M University System (College Station, Texas)
INVENTOR(S) JAMES LEIF SMITH (COLLEGE STATION, Texas);  AKSHAYA RAVICHANDRAN (COLLEGE STATION, Texas);  SHIEN LU (STARKVILLE, Mississippi);  GANYU GU (PAINTER, Virginia)
ABSTRACT Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
FILED Monday, December 07, 2020
APPL NO 17/113764
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 43/713 (20130101)
A01N 63/50 (20200101) Original (OR) Class

Preparations for Medical, Dental, or Toilet Purposes
A61K 38/12 (20130101)

Peptides
C07K 7/54 (20130101)
C07K 7/56 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/16 (20130101)

Enzymes
C12Y 301/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Homeland Security (DHS) 

US 20220012752 Ellison et al.
FUNDED BY
Department of Homeland Security (DHS)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S) Chang Ellison (Arlington, Virginia);  Kelli L. Biegger (McLean, Virginia);  Daniel A. Boyd (Arlington, Virginia);  Brandon P. Gutierrez (Burke, Virginia);  Jason Lim (Alexandria, Virginia)
ABSTRACT In an example, a subject using a user mobile-identification-credential device (UMD) requests vetting by a vetting system, which receives verified subject information associated with a level-n mobile identification credential (MIC-n) that UMD received from a level-n authorizing party system (APS-n). MIC-n is linked to lower level MIC-0 to MIC-(n−1). The vetting system, as level-n relying party system (RPS-n), uses the verified subject information associated with the linked MIC-0 to MIC-n to verify or not verify the identity of the subject, develops an identity profile of the subject, and determines a vetting result of the subject by calculating a composite trust score based on MIC trust values for the multiple levels of MIC. MIC-i (i=1 to n) is linked to MIC-(i−1) which UMD received from APS-(i−1), and APS-i is RPS-(i−1) which verified the identity of the subject using verified subject information associated with MIC-(i−1), such that MIC-0 to MIC-n are linked.
FILED Thursday, July 22, 2021
APPL NO 17/383151
CURRENT CPC
Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 30/018 (20130101) Original (OR) Class

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/3213 (20130101)

Wireless Communication Networks
H04W 12/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220014907 Boyd et al.
FUNDED BY
Department of Homeland Security (DHS)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S) Daniel A. Boyd (Arlington, Virginia);  Kelli L. Biegger (McLean, Virginia);  Chang Ellison (Arlington, Virginia);  Brandon P. Gutierrez (Burke, Virginia);  Jason Lim (Alexandria, Virginia);  William Washington (North Potomac, Maryland)
ABSTRACT A stopped vehicle information remote retrieval method includes an emergency personnel or first responder vehicle (FRV) establishing a vehicle connection between an infotainment system of a stopped vehicle and the FRV. The FRV sends a vehicle information request to the infotainment system of the stopped vehicle, via the vehicle connection, seeking release of vehicle information. The FRV obtains authentication of the vehicle information received in response to the vehicle information request. The FRV determines occupant status based on the vehicle information. The FRV communicates the passenger status to a first responder.
FILED Friday, February 19, 2021
APPL NO 17/180334
CURRENT CPC
Wireless Communication Networks
H04W 4/46 (20180201)
H04W 12/02 (20130101)
H04W 12/04 (20130101) Original (OR) Class
H04W 12/033 (20210101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Transportation (USDOT) 

US 20220009834 Fatmehsari et al.
FUNDED BY
Department of Transportation (USDOT)
Federal Highway Administration (FHWA)
APPLICANT(S) NUtech Ventures (Lincoln, Nebraska)
ASSIGNEE(S) NUtech Ventures (Lincoln, Nebraska)
INVENTOR(S) Hamzeh Haghshenas Fatmehsari (Lincoln, Nebraska);  Robert Rea (Ashland, Nebraska)
ABSTRACT An asphalt pavement modification system and method for improving aging resistance of asphalt pavement and a method of manufacturing reclaimed asphalt pavement. The asphalt pavement modification system and method include using one or more antioxidants and one or more recycling agents in a blended binder to provide improved short term and long term performance of the asphalt pavement. The method of manufacturing reclaimed asphalt pavement includes mixing at least one antioxidant with at least one recycling agent to form a binder that constitutes a portion of the reclaimed asphalt pavement. One of the antioxidants may be zinc diethyldithiocarbamate.
FILED Friday, July 09, 2021
APPL NO 17/371478
CURRENT CPC
Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 26/003 (20130101) Original (OR) Class
C04B 26/26 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

United States Postal Service (USPS) 

US 20220012911 TOWNSEND et al.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) UNITED STATES POSTAL SERVICE (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Andrew TOWNSEND (Clifton, Virginia);  David LIN (Merrifield, Virginia);  Barry E. RUSSELL (Falls Church, Virginia);  Roger WORNER (Saint Peters, Missouri)
ABSTRACT A computer-implemented system, method and computer-program product are configured to receive an image of a location from at least one image sensor device; analyze the image to determine a distance between a person and an object in the image; and output a control signal when the determined distance between the person and the object is below a predetermined threshold distance. The control signal causes an electronic device at the location to perform an action related to the distance between the person and the object. The object may be another person.
FILED Tuesday, July 13, 2021
APPL NO 17/373847
CURRENT CPC
Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements
G05B 15/02 (20130101)

Image Data Processing or Generation, in General
G06T 7/74 (20170101) Original (OR) Class
G06T 2207/30196 (20130101)

Signalling or Calling Systems; Order Telegraphs; Alarm Systems
G08B 21/182 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Government Rights Acknowledged 

US 20220009633 Budd et al.
FUNDED BY
APPLICANT(S) Sky Launch Corporation (Lancaster, California)
ASSIGNEE(S)
INVENTOR(S) Gerald D. Budd (Lancaster, California);  Charles E. Rogers (Lancaster, California)
ABSTRACT Embodiments of a system and method for carrying an aeronautical or launch vehicle to altitude for release to flight are disclosed. The system may comprise a multiplicity of mounting elements configured to be affixed to a carrier aircraft in distributed fashion along a mounting axis. Each mounting element may include a cradle and a retention strap. Each retention strap may be suspendedly attached to a respective said cradle, and actuatable from a retention configuration to a release configuration. The retention configuration may enable the retention straps to clampingly secure the vehicle to the respective cradles. The actuation of the retention straps from the retention configuration to the release configuration may disable the clamping securement and thereby release the vehicle to drop away from the cradles. For one or more of the retention straps, the actuation may be by way of detonating at least one corresponding pyrotechnic fastener.
FILED Friday, July 09, 2021
APPL NO 17/372388
CURRENT CPC
Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft
B64D 1/02 (20130101)
B64D 5/00 (20130101) Original (OR) Class
B64D 27/023 (20130101)

Explosive Charges, e.g for Blasting, Fireworks, Ammunition
F42B 3/006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

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THE FEDINVENT PATENT APPLICATION DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Thursday, January 13, 2022.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
     National Institutes of Health (NIH)
         National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
     Defense Advanced Research Projects Agency (DARPA)
         Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
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FILED
The date the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

  • A61B 1/149 (20130101)
  • A61B 1/71 (20130101)
  • A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
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You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html

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