FedInvent™ Patent Applications
Application Details for Thursday, January 20, 2022
This page was updated on Saturday, January 22, 2022 at 01:04 AM GMT
Department of Health and Human Services (HHS)
| US 20220015363 | Gitai et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Zemer Gitai (Princeton, New Jersey); Robert J. Scheffler (Baltimore, Maryland); Mohamed Abou Donia (Princeton, New Jersey); Yuki Sugimoto (Cambridge, Massachusetts) |
| ABSTRACT | A system and method for dispersing pathogens having Type IV pili that are surface-attached to a surface or preventing pathogens from surface-attaching to a surface, using a certain quinolone compounds (such as 2-methyl-4-hydroxyquinolone (MHQ)) as dispersing agents. |
| FILED | Monday, July 12, 2021 |
| APPL NO | 17/372952 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/04 (20130101) A01N 43/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220015832 | DiMaio et al. |
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| FUNDED BY |
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| APPLICANT(S) | Intuitive Surgical Operations, Inc. (Sunnyvale, California); The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simon P. DiMaio (San Carlos, California); Christopher J. Hasser (Los Altos, California); Russell H. Taylor (Severna Park, Maryland); David Q. Larkin (Menlo Park, California); Peter Kazanzides (Towson, Maryland); Anton Deguet (Baltimore, Maryland); Balazs Peter Vagvolgyi (Baltimore, Maryland); Joshua Leven (San Francisco, California) |
| ABSTRACT | A minimally invasive surgical system is disclosed including a processor coupled to a stereoscopic endoscope and a stereoscopic video display device. The processor generates an operative image of an anatomic structure in the surgical site, overlays the operative image onto the captured stereo video images for display on the stereoscopic video display device, generates and overlays a pointer onto the operative image or the captured stereo video images to display the pointer on the stereoscopic video display device with a three dimensional appearance, and switches between a first mode for input devices of a surgeon console used to couple motion into surgical instruments and a second mode used to control an interactive graphical user interface to allow interactions with the pointer and the operative image in three dimensions using input devices having at least three degrees of freedom. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/468198 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00193 (20130101) A61B 8/00 (20130101) A61B 8/12 (20130101) A61B 8/4245 (20130101) A61B 34/10 (20160201) Original (OR) Class A61B 34/30 (20160201) A61B 34/37 (20160201) A61B 34/70 (20160201) A61B 34/71 (20160201) A61B 34/76 (20160201) A61B 2017/00203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016051 | LOPACHIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | MONTEFIORE MEDICAL CENTER (Bronx, New York) |
| ASSIGNEE(S) | MONTEFIORE MEDICAL CENTER (Bronx, New York) |
| INVENTOR(S) | Richard LOPACHIN (New York, New York); Brian C. GEOHEGAN (New York, New York) |
| ABSTRACT | Methods and compositions are disclosed for reducing neuropathy or ototoxicity associated with chemotherapeutic agents by administering one or more enol compounds to a subject. |
| FILED | Friday, December 27, 2019 |
| APPL NO | 17/309702 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 31/122 (20130101) Original (OR) Class A61K 31/167 (20130101) A61K 31/282 (20130101) A61K 33/243 (20190101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016056 | GURTNER et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey C. GURTNER (Portola Valley, California); Jayakumar RAJADAS (Cupertino, California); Michael Gabriel GALVEZ (Palo Alto, California); Evgenios NEOFYTOU (Stanford, California) |
| ABSTRACT | Compositions and methods are provided for the prevention and treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1α in the wound. |
| FILED | Tuesday, September 28, 2021 |
| APPL NO | 17/487856 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0014 (20130101) A61K 9/1075 (20130101) A61K 9/7023 (20130101) A61K 9/7053 (20130101) A61K 9/7069 (20130101) A61K 31/16 (20130101) Original (OR) Class A61K 47/26 (20130101) A61K 47/32 (20130101) A61K 47/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016063 | VIDYASAGAR et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORDIA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sadasivan VIDYASAGAR (Gainesville, Florida); James COLLINS (Gainesville, Florida); Regina WOLOSHUN (Gainesville, Florida) |
| ABSTRACT | Amino acid compositions useful for increasing the amount of the divalent metal-ion transporter 1, DMT1 (encoded by the gene SLC11A2), on the duodenal bmsh border membrane (BBM) are described herein. Methods for increasing the concentration of DMT1 on the duodenal BBM (on trafficking) and increasing iron uptake are also presented. Compositions and methods described herein are useful for treating a disorder or disease associated with iron deficiency in subjects afflicted with such disorders or diseases. Use of these compositions for the treatment of disorders or diseases associated with iron deficiency and in the preparation of a medicament for the treatment of disorders or diseases associated with iron deficiency are also encompassed herein. |
| FILED | Friday, December 06, 2019 |
| APPL NO | 17/311234 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016075 | Baker et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bill J. Baker (Temple Terrace, Florida); Kyle Rohde (Orlando, Florida); Bingjie Yang (Temple Terrace, Florida); Marisa Fuse (Winter Springs, Florida) |
| ABSTRACT | The present disclosure provides methods for the treatment of infections with Mycobacterium such as tuberculosis or leprosy. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375403 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/12 (20130101) A61K 31/44 (20130101) A61K 31/133 (20130101) A61K 31/145 (20130101) A61K 31/192 (20130101) A61K 31/235 (20130101) A61K 31/343 (20130101) A61K 31/352 (20130101) A61K 31/365 (20130101) A61K 31/366 (20130101) Original (OR) Class A61K 31/454 (20130101) A61K 31/472 (20130101) A61K 31/496 (20130101) A61K 31/498 (20130101) A61K 31/505 (20130101) A61K 31/4015 (20130101) A61K 31/4045 (20130101) A61K 31/4409 (20130101) A61K 31/7036 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016100 | Edge et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert Edge (Brookline, Massachusetts); Yenfu Cheng (Boston, Massachusetts) |
| ABSTRACT | Methods for treating hearing loss that include administering an inhibitor, e.g., a small molecule inhibitor, of casein kinase 1, preferably in combination with a treatment that stimulates Atoh1 gene expression, e.g., a gamma-secretase inhibitor, an Atoh1 stimulatory compound, or a GSK-3-beta inhibitor. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/450377 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0046 (20130101) A61K 31/437 (20130101) A61K 31/4439 (20130101) Original (OR) Class A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) Heterocyclic Compounds C07D 401/04 (20130101) C07D 403/04 (20130101) C07D 405/14 (20130101) C07D 413/14 (20130101) C07D 487/04 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016106 | Sykes et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); THE GENERAL HOSPITAL CORPORATION (BOSTON, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts); BAYER PHARMA AKTIENGESELLSCHAFT (BERLIN, Germany) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); THE GENERAL HOSPITAL CORPORATION (BOSTON, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts); BAYER PHARMA AKTIENGESELLSCHAFT (BERLIN, Germany) |
| INVENTOR(S) | David B. Sykes (Boston, Massachusetts); David Scadden (Boston, Massachusetts); Timothy A. Lewis (Cambridge, Massachusetts); Andreas Janzer (Berlin, Germany); Hanna Meyer (Berlin, Germany); Detlef Stöckigt (Potsdam, Germany) |
| ABSTRACT | The present invention includes methods of treating patients with acute myeloid leukemia across a range of genetic subtypes with DHODH inhibitors, such as 6-fluoro-2-(2′-fluoro-[1,1′-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid). |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/383161 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/27 (20130101) A61K 31/42 (20130101) A61K 31/47 (20130101) Original (OR) Class A61K 31/277 (20130101) A61K 31/505 (20130101) A61K 33/36 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016130 | Huang |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
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| INVENTOR(S) | Haojie Huang (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials involved in identifying and treating mammals having a cancer resistant to BET inhibitors. For example, methods and materials for administering (a) one or more AKT inhibitors and/or one or more CDK inhibitors and/or one or more CBP/p300 inhibitors in combination with (b) one or more BET inhibitors to mammals identified as having a cancer resistant to treatment with one or more BET inhibitors in the absence of AKT, CDK, and CBP/p300 inhibitors are provided. |
| FILED | Thursday, July 25, 2019 |
| APPL NO | 17/263010 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/551 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016131 | Mitra et al. |
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| FUNDED BY |
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| APPLICANT(S) | Robi Mitra (St. Louis, Missouri); Arnav Moudgil (St. Louis, Missouri); Michael Nathaniel Wilkinson (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Robi Mitra (St. Louis, Missouri); Arnav Moudgil (St. Louis, Missouri); Michael Nathaniel Wilkinson (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of a methods for increasing chemotherapy sensitivity or decreasing chemotherapy resistance using BET inhibitors. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/371750 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/551 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016135 | Ince |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
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| INVENTOR(S) | Tan Ince (Miami, Florida) |
| ABSTRACT | The invention provides a classification and treatment system for breast cancer using measurements of and ligands for estrogen receptor, androgen receptor, vitamin D receptor, and optionally HER2 receptor. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 16/931303 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/337 (20130101) A61K 31/517 (20130101) A61K 31/565 (20130101) A61K 31/567 (20130101) A61K 31/593 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016138 | Devlin et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Flarvard College (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Abigail Sloan Devlin (Cambridge, Massachusetts); Snehal N. Chaudhari (Cambridge, Massachusetts); Eric Garland Sheu (Brookline, Massachusetts); David A. Harris (Arlington, Massachusetts); Jinbo Lee (Cambridge, Massachusetts) |
| ABSTRACT | The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), or an inflammatory disease (e.g., Crohn's disease, inflammatory bowel disease, ulcerative colitis, pancreatitis, hepatitis, appendicitis, gastritis, diverticulitis, celiac disease, food intolerance, enteritis, ulcer, gastroesophageal reflux disease (GERD), psoriatic arthritis, psoriasis, and rheumatoid arthritis) in a subject in need thereof comprising administering to a subject a compound of Formulae (I)-(XVII). |
| FILED | Wednesday, December 04, 2019 |
| APPL NO | 17/309520 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/575 (20130101) A61K 31/664 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016139 | Heneine et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| INVENTOR(S) | Walid Heneine (Atlanta, Georgia); Thomas M. Folks (Helotes, Texas); Robert Janssen (Atlanta, Georgia); Ronald A. Otten (Villa Rica, Georgia); Jose Gerardo Garcia Lerma (Decatur, Georgia) |
| ABSTRACT | A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host. A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 9/0053 (20130101) A61K 31/513 (20130101) A61K 31/675 (20130101) Original (OR) Class A61K 31/683 (20130101) A61K 31/7072 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016140 | Heneine et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Walid Heneine (Atlanta, Georgia); Thomas M. Folks (Helotes, Texas); Robert Janssen (Atlanta, Georgia); Ronald A. Otten (Villa Rica, Georgia); Jose Gerardo Garcia Lerma (Decatur, Georgia) |
| ABSTRACT | A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host. A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186559 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 9/0053 (20130101) A61K 31/513 (20130101) A61K 31/675 (20130101) Original (OR) Class A61K 31/683 (20130101) A61K 31/7072 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016141 | Heneine et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland) |
| INVENTOR(S) | Walid Heneine (Atlanta, Georgia); Thomas M. Folks (Helotes, Texas); Robert Janssen (Atlanta, Georgia); Ronald A. Otten (Villa Rica, Georgia); Jose Gerardo Garcia Lerma (Decatur, Georgia) |
| ABSTRACT | A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host. A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186583 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0034 (20130101) A61K 9/0053 (20130101) A61K 31/513 (20130101) A61K 31/675 (20130101) Original (OR) Class A61K 31/683 (20130101) A61K 31/7072 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016148 | Burridge |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul W. Burridge (Chicago, Illinois) |
| ABSTRACT | Disclosed are methods, pharmaceutical compositions, kits, and systems for treating or preventing cardiotoxicity in a subject undergoing treatment with an anthracycline chemotherapeutic agent. The methods, pharmaceutical compositions, kits, and systems typically include or utilize an agonist of the retinoic acid receptor gamma (RARG). |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493571 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 31/196 (20130101) A61K 31/381 (20130101) A61K 31/415 (20130101) A61K 31/704 (20130101) Original (OR) Class A61K 31/4436 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016153 | PAINTER et al. |
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| FUNDED BY |
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| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George R. PAINTER (Atlanta, Georgia); Gregory R. Bluemling (Decatur, Georgia); Michael G. Natchus (Alpharetta, Georgia); David Guthrie (Avondale Estates, Georgia) |
| ABSTRACT | This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds. |
| FILED | Thursday, September 02, 2021 |
| APPL NO | 17/465344 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7068 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016170 | Sadelain et al. |
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| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Michel Sadelain (New York, New York); Matthias Stephan (Boston, Massachusetts) |
| ABSTRACT | The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381587 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/217 (20130101) A61K 38/2013 (20130101) A61K 39/0011 (20130101) A61K 45/06 (20130101) A61K 2035/122 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 7/00 (20130101) C12N 15/85 (20130101) C12N 2501/25 (20130101) C12N 2501/51 (20130101) C12N 2501/599 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016175 | Shen |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hua Shen (St. Louis, Missouri) |
| ABSTRACT | Disclosed herein are bionanoparticles of adipose-derived stem cell extracellular vesicles, a tissue repair matrix comprising the bionanoparticles, and methods of use thereof for enhanced tendon healing. |
| FILED | Friday, November 15, 2019 |
| APPL NO | 17/294006 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3834 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0667 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016191 | Weiss et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ron Weiss (Newton, Massachusetts); Jin Huh (Watertown, Massachusetts); Yingzhong Li (Quincy, Massachusetts) |
| ABSTRACT | Disclosed herein are genetically modified herpesviruses for the treatment of cancer. Also provided are methods of treating cancer using genetically modified herpesviruses. |
| FILED | Friday, May 14, 2021 |
| APPL NO | 17/320965 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/763 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2710/16632 (20130101) C12N 2710/16643 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016199 | RADISIC et al. |
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| FUNDED BY |
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| APPLICANT(S) | Quthero, Inc. (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milica RADISIC (Toronto, Canada); Yun XIAO (Toronto, Canada); Lewis REIS (Toronto, Canada); Serena MANDLA (Toronto, Canada) |
| ABSTRACT | The invention provides a composition and pharmaceutical formulation including a peptide immobilized in a hydro gel. Compositions and formulations of the invention are useful in reducing the size, severity or duration of a wound, ameliorating of one or more symptoms associated with a wound without necessarily curing the wound, or lessening in the growth or severity of a wound. Compositions and formulations of the invention are particularly useful in the treatment of a wound associated with diabetes, such as a diabetic ulcer. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/184745 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/7084 (20130101) A61K 38/08 (20130101) Original (OR) Class A61K 47/6903 (20170801) A61K 47/6953 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/44 (20130101) A61L 26/008 (20130101) A61L 26/0066 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016203 | Weeraratna |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashani T. Weeraratna (Merion Station, Pennsylvania) |
| ABSTRACT | Compositions and methods for the prevention or reduction of metastasis are provided. Such compositions and methods include increasing the level or expression of HAPLN 1. |
| FILED | Wednesday, October 02, 2019 |
| APPL NO | 17/281796 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/15032 (20130101) C12N 2740/15043 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5743 (20130101) G01N 33/6887 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016206 | TING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Kang TING (Beverly Hills, California); B. Chia SOO (Beverly Hills, California) |
| ABSTRACT | This application is drawn to a method of using an isoform NELL-1 peptide, and compositions thereof for bone formation or for treating, preventing, or ameliorating osteoporosis. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/315593 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/32 (20130101) A61K 38/1709 (20130101) Original (OR) Class Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0092 (20130101) A61M 2037/0007 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/303 (20130101) Peptides C07K 14/47 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016224 | Wyss-Coray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton Wyss-Coray (Palo Alto, California); Joseph M. Castellano (Tuckahoe, New York) |
| ABSTRACT | Methods of treating an adult mammal for an aging-associated condition are provided. Aspects of the methods include enhancing a TIMP activity, e.g., a TIMP2 activity, in the mammal in a manner sufficient to treat the adult mammal for the aging-associated condition. Also provided are compositions for use in practicing methods of the invention. A variety of aging-associated conditions may be treated by practice of the methods, which conditions include cognitive impairments. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/496986 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/55 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016241 | Balu-Iyer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Amherst, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sathy Balu-Iyer (Amherst, New York); Matthew Pierson Kosloski (Wilmette, Illinois); Krithika Arun Shetty (Buffalo, New York); Jennifer Leigh Schneider (Buffalo, New York); Anas M. Fathallah (San Diego, California) |
| ABSTRACT | Provided are methods for inducing immune tolerance to antigens including therapeutic antigens. The present methods comprise administering to an individual OPLS or other lipidic compositions and the antigen, either in a single formulation or as separate formulations where the separate formulations are administered concomitantly or sequentially. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/443562 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 2039/54 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016250 | SCHNEIDER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Joel SCHNEIDER (Frederick, Maryland); Poulami MAJUMDER (Frederick, Maryland); Giorgio RAIMONDI (Sevenma, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joel P. SCHNEIDER (Frederick, Maryland); Poulami MAJUMDER (Frederick, Maryland); Giorgio RAIMONDI (Severna Park, Maryland) |
| ABSTRACT | Compositions that include a cationic peptide hydrogel and an immunosuppressive small molecule drug are described. The small molecule drug is crystallized and dispersed in the peptide hydrogel to allow for slow release of the drug. Methods of inhibiting allograft rejection and treating autoimmune-mediated organ damage by local administration of the peptide hydrogel compositions are described. |
| FILED | Friday, May 03, 2019 |
| APPL NO | 17/051574 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 47/20 (20130101) A61K 47/42 (20130101) Original (OR) Class A61K 47/6903 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 14/001 (20130101) C07K 14/70503 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016267 | HABER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CITY OF HOPE (Duarte, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tom HABER (Pasadena, California); Pengpeng CAO (Duarte, California); Jacob BERLIN (Monrovia, California); Karen ABOODY (Arcadia, California) |
| ABSTRACT | Disclosed herein, inter alia, are methods for detecting cancer using nanoparticles. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/408972 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/005 (20130101) Original (OR) Class A61K 49/0017 (20130101) A61K 49/0093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016271 | Farokhzad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omid C. Farokhzad (Waban, Massachusetts); Na Kong (Boston, Massachusetts); Jinjun Shi (Boston, Massachusetts); Wei Tao (Brookline, Massachusetts) |
| ABSTRACT | The present application provides a method of treating a cancer, including administering to a subject in need of cancer treatment a therapeutically effective amount of an mRNA encoding tumor suppressor protein p53 in combination with an anticancer therapeutic agent, or a pharmaceutically acceptable salt thereof, wherein the anticancer therapeutic agent is selected from an mTOR inhibitor, a platinum-based antineoplastic agent, and an AMPK activating agent. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 17/413061 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/155 (20130101) A61K 31/436 (20130101) A61K 33/243 (20190101) A61K 38/1758 (20130101) A61K 51/0408 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016277 | Babich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | John W. Babich (New York, New York); Justin WILSON (Ithaca, New York); Nikki THIELE (Kingston, Tennessee); James M. Kelly (New York, New York); Shashikanth Ponnala (New York, New York) |
| ABSTRACT | The present technology provides compounds as well as compositions including such compounds useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing prostate specific membrane antigen (“PSMA”) where the compounds are represented by the following Formulas (I), or a pharmaceutically acceptable salt thereof (IA), or a pharmaceutically acceptable salt thereof (II), or a pharmaceutically acceptable salt thereof, wherein M1 is independently at each occurrence an alpha-emitting radionuclide. Equivalents of such compounds are also disclosed. |
| FILED | Wednesday, November 20, 2019 |
| APPL NO | 17/294375 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0482 (20130101) A61K 51/1072 (20130101) Original (OR) Class Heterocyclic Compounds C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016316 | BITAR |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wake Forest University Health Sciences (Winston-Salem, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Khalil BITAR (Winston-Salem, North Carolina) |
| ABSTRACT | The present disclosure provides methods of bioengineering sphincters having autologous smooth muscle cells isolated from human internal anal sphincter and autologous enteric neurospheres (neural progenitor cells) isolated from human small intestine (jejunum). The isolated neural progenitor cells and smooth muscle cells are co -cultured using dual layered hydrogels and allowed to form circular, intrinsically innervated internal anal sphincter constructs. Such innervated internal anal sphincter constructs, bioengineered internal anal sphincter constructs are useful as additive implants in the treatment of fecal incontinence. |
| FILED | Thursday, November 14, 2019 |
| APPL NO | 17/294312 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/04 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/367 (20130101) Original (OR) Class A61L 27/3629 (20130101) A61L 27/3687 (20130101) A61L 27/3691 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016318 | Maninishkis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATE OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARMENT OF HEALTH AND HUMAN SERVICE (Bethesda, Maryland) |
| ASSIGNEE(S) | THE UNITED STATE OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARMENT OF HEALTH AND HUMAN SERVICES (Bethesda, Maryland) |
| INVENTOR(S) | Arvydas Maninishkis (Washington, District of Columbia); Kapil Bharti (Potomac, Maryland) |
| ABSTRACT | Tissue replacement implants are disclosed that include polarized retinal pigment epithelial cells on a polylactic-co-glycolic acid) (PLGA) scaffold, wherein the PLGA scaffold is 20-30 microns in thickness, has a DL-lactide/glycotide ratio of about 1:1, an average pore size of less than about 1 micron, and a fiber diameter of about 150 to about 650 nm. Also disclosed are methods of treating a subject with a retinal degenerative disease, retinal or retinal pigment epithelium dysfunction, retinal degradation, retinal damage, or loss of retinal pigment epithelium. These methods include locally administering to the eye of the subject the tissue replacement implant. In further embodiments, methods are disclosed for producing the tissue replacement implant. |
| FILED | Monday, November 18, 2019 |
| APPL NO | 17/295030 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 27/3813 (20130101) Original (OR) Class A61L 27/3834 (20130101) A61L 27/3869 (20130101) A61L 2430/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016420 | Lo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Yi-Kai Lo (Los Angeles, California); Wentai Liu (Los Angeles, California); Victor R. Edgerton (Los Angeles, California); Chih-Wei Chang (Los Angeles, California) |
| ABSTRACT | A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/459483 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/08 (20130101) A61N 1/0551 (20130101) A61N 1/3787 (20130101) A61N 1/36003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016424 | Ayata et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cenk Ayata (Sudbury, Massachusetts); Aman B. Patel (Cambridge, Massachusetts) |
| ABSTRACT | A system and method is provided for improving the patient outcome for a subject having an aneurysm. The method includes determining that the subject has the aneurysm, positioning a vagus nerve stimulation system on the subject, the vagus nerve stimulation system being configured to provide an electrical stimulation to the vagus nerve of the subject. Stimulating the vagus nerve of the subject with the vagus nerve stimulation system to at least one of: prevent further growth of the aneurysm; decrease the likelihood that the aneurysm ruptures; and decrease effects of rupture, when the aneurysm of the subject ruptures. |
| FILED | Wednesday, November 20, 2019 |
| APPL NO | 17/295099 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36034 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016434 | IVRY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | RICHARD IRWIN IVRY (El Cerrito, California); DANIEL J. SHELTRAW (Albany, California); LUDOVICA LABRUNA (Kensington, California); BENJAMIN A. INGLIS (Lafayette, California) |
| ABSTRACT | A magnetic stimulation system includes a magnetic coil to generate an electric field of a magnitude having a desired effect on a brain, a voltage to current source to generate a current waveform having an amplitude and frequency to produce the electric field, and a controller to control the voltage to current source and to apply the current to the magnetic coil to provide perturbation of brain tissue using one or more periods of either continuously induced electric field with constant amplitude and frequency, or periods of electric field with at least one of amplitude and frequency modulation. A method of magnetically stimulating a brain includes placing a coil near a brain, and applying a current having an amplitude and frequency to the coil to produce an electric field having a desired effect on the brain, wherein the amplitude and frequency are applied using one of either one or more periods of continuously induced electric fields with constant amplitude and frequency, or periods of an electric field with at least one of either amplitude and frequency modulation. |
| FILED | Wednesday, November 27, 2019 |
| APPL NO | 17/311596 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) A61N 2/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016612 | Zhao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Zhao (Ames, Iowa) |
| ABSTRACT | The disclosure relates to molecularly-imprinted cross-linked micelles that can selectively hydrolyze carbohydrates. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/368257 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/067 (20130101) Original (OR) Class B01J 35/0013 (20130101) B01J 37/04 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) Polysaccharides; Derivatives Thereof C08B 15/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016613 | Betley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Theodore Alexander Betley (Cambridge, Massachusetts); Alexandre Mikhailine (Cambridge, Massachusetts); Claudia Kleinlein (Cambridge, Massachusetts); Yuyang Dong (Cambridge, Massachusetts); Yunjung Baek (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed are compounds, methods, reagents, systems, and kits for the preparation and utilization of monomeric or polymeric metal-based compounds. These metal-based compounds are organometallic catalysts composed of substituted dipyrrin ligands bound to transition metals. C—H bond functionalization catalysis can be performed with the disclosed organometallic catalysts to yield C—N bonds to generate substituted bicyclic, spiro, and fused nitrogen-containing heterocycles, all common motifs in various pharmaceutical and bioactive molecules. |
| FILED | Thursday, September 19, 2019 |
| APPL NO | 17/276855 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1815 (20130101) Original (OR) Class B01J 31/2243 (20130101) B01J 2231/4283 (20130101) B01J 2531/0216 (20130101) B01J 2531/842 (20130101) B01J 2531/845 (20130101) B01J 2531/847 (20130101) B01J 2540/66 (20130101) Heterocyclic Compounds C07D 207/06 (20130101) C07D 209/04 (20130101) C07D 209/44 (20130101) C07D 209/54 (20130101) C07D 211/70 (20130101) C07D 263/04 (20130101) C07D 401/04 (20130101) C07D 403/04 (20130101) C07D 471/04 (20130101) C07D 471/08 (20130101) C07D 487/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016617 | Mendoza et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Estevan Mendoza (Mountain View, California); Eric Warner (Oceanside, California) |
| ABSTRACT | Embodiments in accordance with the present disclosure are directed to sample collecting and dispensing methods and apparatuses. An example apparatus includes a capillary sampler disposed on a device first end, wherein the capillary sampler is configured to collect a fluid sample via an opening and a capillary body. The apparatus further includes a reagents chamber in fluid communication with the capillary sampler, and a barrier assembly disposed between the capillary sampler and the reagents chamber, wherein the barrier assembly is configured to separate fluid in the reagents chamber from the capillary sampler. A plunger assembly disposed on a device second end opposite the device first end, may modify the barrier assembly to dispense the fluid from the reagents chamber to the capillary sampler responsive to application of a force in the direction of the device first end. |
| FILED | Wednesday, August 21, 2019 |
| APPL NO | 17/295195 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/022 (20130101) Original (OR) Class B01L 3/502 (20130101) B01L 2200/16 (20130101) B01L 2200/026 (20130101) B01L 2200/0684 (20130101) B01L 2300/14 (20130101) B01L 2300/044 (20130101) B01L 2300/048 (20130101) B01L 2300/123 (20130101) B01L 2300/161 (20130101) B01L 2300/0838 (20130101) B01L 2400/0406 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/14 (20130101) G01N 2001/149 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017453 | Ruprecht et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisiana at Lafayette (Lafayette, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruth Ruprecht (San Antonio, Texas); Siqi Gong (San Antonio, Texas) |
| ABSTRACT | Described herein are methods of inducing an immune response directed towards preventing or reducing the risk of a human immunodeficiency virus (HIV) infection in a mammalian subject. The subject is administered an effective amount of a composition containing IgM antibodies directed to an epitope of an envelope protein of the HIV virus. Also disclosed here are vaccine compositions comprising IgM antibodies directed to one or more epitopes of one or more human immunodeficiency virus envelope proteins. Also disclosed are recombinant immunoglobulin M compositions containing a Fcγ fragment of an immunoglobulin G. |
| FILED | Monday, May 06, 2019 |
| APPL NO | 17/052671 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1805 (20130101) Acyclic or Carbocyclic Compounds C07C 209/68 (20130101) Original (OR) Class C07C 211/48 (20130101) C07C 227/32 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017454 | RAJ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Ganesh RAJ (Plano, Texas); Jung-Mo AHN (Plano, Texas); Ratna K. VADLAMUDI (Helotes, Texas) |
| ABSTRACT | The present disclosure compounds of the formulae: wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods for the use of said compounds and/or pharmaceutical compositions, such as in the treatment of cancer. |
| FILED | Thursday, June 03, 2021 |
| APPL NO | 17/337830 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 235/56 (20130101) Original (OR) Class Heterocyclic Compounds C07D 215/38 (20130101) C07D 231/56 (20130101) C07D 233/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017495 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaoyuan CHEN (Bethesda, Maryland); Gang NIU (Bethesda, Maryland); Lixin LANG (Bethesda, Maryland); Rui TIAN (Bethesda, Maryland); Dale O. KIESEWETTER (Bethesda, Maryland) |
| ABSTRACT | A compound of Formula (I) or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt, is disclosed. Compositions comprising the compound and methods of use are also disclosed. Those dimeric Evans Blue derivatives, denoted as N(tEB)2, reversibly bind two molecules of albumin via the two albumin binding regions of each NtEB in the dimer, resulting in significantly increased binding affinity to albumin and extended circulation half-life in vivo. Further, when the N(tEB)2 is conjugated to a peptide therapeutic, the in situ formation of the complex of N(tEB)2 with two albumin molecules resulted in increased resistance of the peptide therapeutic from proteolysis. |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 17/294914 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/545 (20170801) A61K 47/547 (20170801) A61K 51/0461 (20130101) A61K 51/0482 (20130101) A61K 51/0497 (20130101) Acyclic or Carbocyclic Compounds C07C 309/50 (20130101) Heterocyclic Compounds C07D 251/50 (20130101) C07D 403/12 (20130101) Original (OR) Class C07D 403/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017497 | RIDKY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd RIDKY (Bryn Mawr, Pennsylvania); Christopher NATALE (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention includes compounds, compositions comprising the same, and methods using the compounds and/or compositions therein, for modulating skin pigmentation in a mammalian subject. In certain embodiments, the compounds of the invention treat or prevent skin disorders or diseases associated with hyperpigmentation in the subject. In other embodiments, the compounds of the invention act as antagonist to the non-canonical sex steroid hormone receptor GPRE1 and do not bind to a canonical nuclear estrogen receptor (ER). In yet other embodiments, the compounds of the invention comprise acts as agonists to the non-canonical sex steroid hormone receptor PAQR7 and do not bind to a canonical nuclear progesterone receptor (PR). |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/480948 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/49 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/00 (20180101) A61P 17/06 (20180101) A61P 17/14 (20180101) A61P 17/16 (20180101) A61P 17/18 (20180101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101) A61Q 19/02 (20130101) Heterocyclic Compounds C07D 221/16 (20130101) C07D 405/04 (20130101) Original (OR) Class C07D 491/048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017507 | Glenn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey S. Glenn (Palo Alto, California); Michael A. Gelman (New York, New York); Brandon Tavshanjian (San Francisco, California); Kevan Shokat (San Francisco, California); Ingrid Choong (Los Altos, California); Mark Smith (San Francisco, California) |
| ABSTRACT | Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole or a 5-heteroaryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/371653 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Heterocyclic Compounds C07D 277/42 (20130101) C07D 277/44 (20130101) C07D 277/46 (20130101) C07D 417/04 (20130101) C07D 417/12 (20130101) Original (OR) Class C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017509 | Winkler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alyssa Winkler (Ann Arbor, Michigan); Brian Linhares (Ann Arbor, Michigan); Dymytrii Listunov (Ann Arbor, Michigan); Jolanta Grembecka (Ann Arbor, Michigan); Tomasz Cierpicki (Ann Arbor, Michigan); EunGi Kim (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are small molecules that bind to GAS41 and inhibit GAS41 activity, and methods of use thereof for the treatment of cancer. |
| FILED | Wednesday, January 27, 2021 |
| APPL NO | 17/159916 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 409/06 (20130101) C07D 409/14 (20130101) C07D 417/14 (20130101) Original (OR) Class C07D 487/10 (20130101) C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017510 | GRAY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (BOSTON, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | NATHANAEL S. GRAY (JAMAICA PLAIN, Massachusetts); JAEBONG JANG (BOSTON, Massachusetts); DRIES DE CLERCQ (BOSTON, Massachusetts); MICHAEL ECK (BOSTON, Massachusetts); PASI JANNE (NEEDHAM, Massachusetts) |
| ABSTRACT | The present application provides bifunctional compounds of Formula (I): which act as protein degradation inducing moieties for EGFR and/or a mutant thereof. The present application also describes methods for the targeted degradation of EGFR and/or a mutant thereof through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to EGFR and/or a mutant thereof which can be utilized in the treatment of disorders modulated by EGFR or a mutant thereof. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/449027 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/18 (20130101) A61K 47/545 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 417/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017559 | Renslo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam R. Renslo (Oakland, California); Erica M.W. Lauterwasser (Wachenheim, Germany); Shaun D. Fontaine (Walnut Creek, California); Benjamin B. Spangler (San Francisco, California); James A. Wells (Burlingame, California) |
| ABSTRACT | Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237525 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/357 (20130101) A61K 31/404 (20130101) A61K 31/427 (20130101) A61K 31/435 (20130101) A61K 31/437 (20130101) A61K 31/444 (20130101) A61K 31/496 (20130101) A61K 31/513 (20130101) A61K 31/662 (20130101) A61K 31/4025 (20130101) A61K 31/4192 (20130101) A61K 31/4709 (20130101) A61K 31/4745 (20130101) A61K 31/4985 (20130101) A61K 31/7072 (20130101) A61K 31/7076 (20130101) A61K 31/7135 (20130101) A61K 47/64 (20170801) A61K 47/6803 (20170801) A61K 51/0459 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Heterocyclic Compounds C07D 323/02 (20130101) C07D 405/12 (20130101) C07D 405/14 (20130101) C07D 407/12 (20130101) C07D 417/12 (20130101) C07D 417/14 (20130101) C07D 471/14 (20130101) C07D 487/04 (20130101) C07D 491/107 (20130101) C07D 491/113 (20130101) C07D 491/153 (20130101) C07D 493/04 (20130101) C07D 493/14 (20130101) C07D 519/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/1804 (20130101) C07F 9/65517 (20130101) C07F 9/65586 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/06 (20130101) C07H 19/16 (20130101) Original (OR) Class C07H 19/167 (20130101) Peptides C07K 7/06 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017575 | Agbandje-McKenna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Mavis Agbandje-McKenna (Gainesville, Florida); Mario Mietzsch (Gainesville, Florida) |
| ABSTRACT | This disclosure relates to variant AAVrh 10 particles engineered to escape host neutralizing antibodies but retain or improve transduction efficiency, and their use as gene delivery vehicles. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/359324 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2015/8518 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017577 | Kennedy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Kennedy (Denver, Colorado); Chandra Tucker (Denver, Colorado) |
| ABSTRACT | The present invention includes light-controlled and light-independent neurotoxin systems and methods for using such neurotoxin systems for rapidly and locally silencing distinct populations of neurons. |
| FILED | Thursday, November 21, 2019 |
| APPL NO | 17/295736 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/33 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) C12N 15/62 (20130101) Enzymes C12Y 304/24069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017578 | REED et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Infectious Disease Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven G. REED (Bellevue, Washington); Rhea N. COLER (Seattle, Washington); Gregory C. IRETON (Seattle, Washington); Sylvie BERTHOLET (Gaithersburg, Maryland) |
| ABSTRACT | The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sr) antigens, and polynucleotides encoding such compositions and fusion proteins, The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/367812 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/04 (20130101) A61K 2039/55561 (20130101) Peptides C07K 14/35 (20130101) Original (OR) Class C07K 14/285 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/5695 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017579 | CHEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zibo CHEN (Seattle, Washington); Scott BOYKEN (Seattle, Washington); Sherry BERMEO (Seattle, Washington); Robert A. LANGAN (Seattle, Washington); David BAKER (Seattle, Washington) |
| ABSTRACT | Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/482713 |
| CURRENT CPC | Peptides C07K 14/435 (20130101) Original (OR) Class C07K 2319/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017604 | Ellebedy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Ali Ellebedy (St. Louis, Missouri); Aaron Schmitz (St. Louis, Missouri); Jackson Turner (St. Louis, Missouri); Wafaa Al Soussi (St. Louis, Missouri); Michael Diamond (St. Louis, Missouri); Daved Fremont (St. Louis, Missouri); James Brett Case (St. Louis, Missouri); Haiyan Zhao (St. Louis, Missouri); Adrianus Boon (St. Louis, Missouri); Sean Whelan (St. Louis, Missouri); Andrew McCluskey (Holden, Massachusetts); Christopher Negron (Worcester, Massachusetts) |
| ABSTRACT | The present invention relates to antibodies or antigen-binding fragments that are useful for treating coronavirus infections (e.g., COVID-19 caused by SARS-CoV-2). The present invention also relates to various pharmaceutical compositions and methods of treating coronavirus using the antibodies or antigen-binding fragments. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/232796 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017609 | Hansen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut); The Regents of the University of California (Oakland, California); The United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. Hansen (Guilford, Connecticut); Peter M. Glazer (Guilford, Connecticut); Richard H. Weisbart (Los Angeles, California); Robert N. Nishimura (Santa Monica, California); Grace Chan (Monterey Park, California) |
| ABSTRACT | Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193933 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/475 (20130101) A61K 31/513 (20130101) A61K 31/704 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/44 (20130101) C07K 2317/73 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017610 | Aikawa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Masanori Aikawa (Chestnut Hill, Massachusetts); Toshiaki Nakano (Fukuoka, Japan); Shunsuke Katsuki (Brookline, Massachusetts) |
| ABSTRACT | The present invention is directed to antibodies that interact with DLL4 and inhibit it from binding to NOTCH receptors. The invention also includes nucleic acids encoding the antibodies and methods of using the antibodies in research and in the prevention or treatment of various diseases and conditions. |
| FILED | Thursday, November 14, 2019 |
| APPL NO | 17/294147 |
| CURRENT CPC | Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/563 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017613 | Lukacs et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas W. Lukacs (Brighton, Michigan); Vladislav A. Dolgachev (Ann Arbor, Michigan); Steven L. Kunkel (Ann Arbor, Michigan); Cory M. Hogaboam (Ann Arbor, Michigan); Sem H. Phan (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell factor and methods for treating fibrotic and tissue remodeling diseases. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493411 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 9/08 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/22 (20130101) C07K 16/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017715 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DOW GLOBAL TECHNOLOGIES LLC (Midland, Michigan); DOW BRASIL SUDESTE INDUSTRIAL LTDA. (Sao Paulo/Sp, Brazil); ROHM AND HAAS COMPANY (Collegeville, Pennsylvania); YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sidi Chen (Milford, Connecticut); Matthew Dong (San Francisco, California) |
| ABSTRACT | The present invention includes compositions and methods for enhancing T cell based immunotherapy. In certain aspects, the invention includes modified T cells and inhibitors of Dhx37 for use in enhancing T cell based immunotherapy and treating cancer. |
| FILED | Friday, June 22, 2018 |
| APPL NO | 16/625542 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 7/048 (20200101) Original (OR) Class C08J 7/0427 (20200101) C08J 2323/08 (20130101) C08J 2323/14 (20130101) C08J 2475/04 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/62 (20180101) C09D 175/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017863 | Kim |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | H. Lee Moffitt Cancer Center and Research Institute, Inc. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sungjune Kim (Tampa, Florida) |
| ABSTRACT | Disclosed herein are lymphocytes for use in adoptive cell transfer that have chemically- or genetically-inhibited Sirt2 expression. Also disclosed are methods of inhibiting or ablating Sirt2 expression in a T cell ex vivo. Also disclosed are methods of treating cancer in a subject that involves collecting lymphocytes, such as tumor infiltrating lymphocytes (TILs), from the subject, treating the lymphocytes ex vivo to inhibit Sirt2 expression, and transferring the modified lymphocytes back to the subject. |
| FILED | Thursday, February 06, 2020 |
| APPL NO | 17/298257 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/39558 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 2501/065 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017865 | FRAZÃO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts); UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts) |
| INVENTOR(S) | Josias Brito FRAZÃO (Boston, Massachusetts); Scot A. WOLFE (Boston, Massachusetts); Daniel E. BAUER (Boston, Massachusetts); Shuquan RAO (Boston, Massachusetts); Peter E. NEWBURGER (Boston, Massachusetts) |
| ABSTRACT | Provided herein are reagents and methods for targeting the ELANE gene for inhibition. Further provided herein is a method for producing a progenitor cell or a population of progenitor cells having decreased ELANE mRNA or protein expression. |
| FILED | Wednesday, November 27, 2019 |
| APPL NO | 17/297925 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0642 (20130101) Original (OR) Class C12N 9/22 (20130101) C12N 15/907 (20130101) C12N 15/1137 (20130101) C12N 2310/20 (20170501) C12N 2501/22 (20130101) C12N 2501/26 (20130101) C12N 2501/125 (20130101) C12N 2501/2306 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017873 | Thomson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. Thomson (Madison, Wisconsin); William L. Murphy (Waunakee, Wisconsin); Charles D. Page (Sun Prairie, Wisconsin); Michael P. Schwartz (Madison, Wisconsin); Zhonggang Hou (Madison, Wisconsin) |
| ABSTRACT | The present invention relates to three-dimensional (3D) tissue constructs and methods of using such 3D tissue constructs to screen for neurotoxic agents. In particular, provided herein are methods of producing and using complex, highly uniform human tissue models comprising physiologically relevant human cells, where the tissue models have the degree of sample uniformity and reproducibility required for use in quantitative high-throughput screening applications. |
| FILED | Monday, July 12, 2021 |
| APPL NO | 17/373523 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 5/0622 (20130101) C12N 5/0697 (20130101) Original (OR) Class C12N 2502/28 (20130101) C12N 2502/1358 (20130101) C12N 2503/02 (20130101) C12N 2506/02 (20130101) C12N 2533/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017876 | Schaffer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David V. Schaffer (Danville, California); Melissa A. Kotterman (Berkeley, California); Bum-Yeol Hwang (Moraga, California); James T. Koerber (San Mateo, California) |
| ABSTRACT | The present disclosure provides infectious recombinant adeno-associated virus (rAAV) virions that comprise a variant capsid protein and a heterologous nucleic acid. The present disclosure further provides the variant adeno-associated virus (AAV) capsid proteins (and/or a nucleic acid encoding the variant AAV capsid proteins), which confer to an infectious rAAV virion an increased resistance to human AAV neutralizing antibodies. The present disclosure further provides host cells comprising an infectious rAAV virion and/or a nucleic acid encoding a subject variant AAV capsid protein. The present disclosure further provides methods of delivering a heterologous nucleic acid to a target cell where the target cell is contacted with a subject infectious rAAV virion. The present disclosure further provides methods of delivering a gene product to an individual, the methods generally involving administering an effective amount of a subject rAAV virion to an individual in need thereof. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/468290 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 35/761 (20130101) A61K 48/005 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 15/1058 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017882 | Marson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Marson (Oakland, California); Theodore Lee Roth (Oakland, California); Daniel Goodman (Oakland, California); David-Huy Nhu Nguyen (Oakland, California); Francis C. Szoka (Oakland, California) |
| ABSTRACT | The disclosure provides compositions and methods for modifying a target nucleic acid. In some embodiments, a composition can include a targetable nuclease, a DNA-binding protein, and a donor template comprising a homology directed repair (HDR) template and one or more DNA-binding protein target sequences. In some embodiments, a composition can include a Cas protein, one or more single guide RNAs (sgRNAs), and an anionic polymer. |
| FILED | Thursday, December 12, 2019 |
| APPL NO | 17/312191 |
| CURRENT CPC | Peptides C07K 2319/09 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017883 | Joung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Benjamin Kleinstiver (Boston, Massachusetts) |
| ABSTRACT | Engineered CRISPR from Prevotella and Francisella 1 (Cpf1) nucleases with altered and improved target specificity and their use in genomic engineering, epigenomic engineering, genome targeting, genome editing, and in vitro diagnostics. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/450588 |
| CURRENT CPC | Peptides C07K 14/39 (20130101) C07K 2319/00 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/0071 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 114/11 (20130101) C12Y 301/21004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017905 | KEMP et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fred Huchinson Cancer Research Center (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher KEMP (Seattle, Washington); Carla GRANDORI (Seattle, Washington); Eduardo MENDEZ (Seattle, Washington); Russell MOSER (Seattle, Washington); Chang XU (Mercer Island, Washington) |
| ABSTRACT | The present invention provides methods for treating cancers having a mutation in one or more tumor suppressor genes, comprising providing to a subject in need thereof an inhibitor of a kinase, as well as related methods and compositions. |
| FILED | Monday, January 25, 2021 |
| APPL NO | 17/157565 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/407 (20130101) A61K 31/426 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/713 (20130101) A61K 31/4535 (20130101) A61K 31/5377 (20130101) A61K 33/24 (20130101) A61K 33/243 (20190101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017938 | MIKKELSEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (BOSTON, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (BOSTON, Massachusetts) |
| INVENTOR(S) | TARJEI MIKKELSEN (CAMBRIDGE, Massachusetts); BENJAMIN LEVINE EBERT (BOSTON, Massachusetts); QUINLAN SIEVERS (BOSTON, Massachusetts) |
| ABSTRACT | In one aspect, the invention features a method for identifying a drug-modulated polypeptide substrate of cereblon (CRBN). In another aspect, the invention features a method of identifying a polypeptide target of a modulator of CRBN. In yet another aspect, the invention provides methods of monitoring or characterizing the sensitivity of a subject to a modulator of CRBN. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496578 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/025 (20130101) Original (OR) Class C12Q 1/68 (20130101) C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/136 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017945 | DEAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Hospital and Research Center at Oakland (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deborah Anne DEAN (San Anselmo, California); Noor ALNABELSEYA (Oakland, California) |
| ABSTRACT | Disclosed herein are novel methods and compositions for rapidly extracting and amplifying nucleic acids from a sample where the sample is combined with an extraction reagent comprising a reducing agent to form a mixture and incubating said mixture at ambient temperature for a period of time not exceeding 30 minutes to generate a nucleic acid extract. In certain embodiments of the method, the nucleic acid extract is subjected to a nucleic acid amplification reaction. In certain aspects, oligonucleotide primers specific for nucleic acids of Chlamydia species and/or Neisseria species are added prior to initiating the amplification reaction. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 17/374255 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/06 (20130101) C07H 21/00 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017946 | Okereke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ikenna Okereke (Galveston, Texas); Richard Pyles (Galveston, Texas); Aaron Miller (Galveston, Texas); Catherine Hamilton (Galveston, Texas) |
| ABSTRACT | The present invention includes a method of detecting and treating a patient suspected of having Barrett's esophagus comprising: obtaining a biological sample from an esophagus of the patient; determining a microbiome in the biological sample by detecting the presence of bacteria by plasmid dilution verification or quantitative polymerase chain reaction (qPCR); wherein if the patient has a microbiome indicative of an increased risk of esophageal cancer threating the patient with at least one of: removing at least part of the esophagus, esophagectomy probiotic therapy, or chemically targeting elimination of bacteria indicative of an increased risk of esophageal cancer. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375966 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Original (OR) Class C12Q 2600/112 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017961 | SALK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (SEATTLE, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse SALK (Seattle, Washington); Lawrence A. LOEB (Bellevue, Washington); Michael SCHMITT (Seattle, Washington) |
| ABSTRACT | Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/448985 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017965 | Aliferis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Konstantinos Aliferis (Minneapolis, Minnesota); Boris Jan Nils Winterhoff (Minneapolis, Minnesota); Sisi Ma (Minneapolis, Minnesota); Jinhua Wang (Edina, Minnesota) |
| ABSTRACT | This disclosure describes methods of predicting the response of a patient with ovarian cancer to platinum-based chemotherapy and/or treatment with bevacizumab using clinical and molecular tumor characteristics in patients, methods of treating patients with ovarian cancer, and kits for performing all or part of the methods described herein. This disclosure also describes methods that include determining a prediction of an outcome for a patient having ovarian cancer based on one or more signatures and patient test data comprising clinical data, gene expression data, or both. |
| FILED | Thursday, October 31, 2019 |
| APPL NO | 17/290172 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 20/10 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017969 | Curiel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona); George Mason University (Manassas, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clara N. Curiel (Tucson, Arizona); Amanda Fern Baker (Tucson, Arizona); Sally E. Dickinson (Tucson, Arizona); Emanuel F. Petricoin, III (Manassas, Virginia) |
| ABSTRACT | The present invention relates to a method of using family and/or regulatory members of the PD-1/PD-L1 pathway as predictive markers for risk of skin cancer development and as targets for therapeutic prevention of pre-malignant (or pre-cancerous) skin lesions and non-melanoma skin cancer (NMSC). This invention will allow for quantitative measurements of UV-induced expression of PD-1/PD-Li signaling pathway family members (e.g., PD-1, PD-L1, PD-L2) and/or PD-1/PD-L1 regulatory factors including AP-1 and NFκB family members in skin tissue of individuals to determine an individual's 1) risk for skin cancer development and 2) appropriate prophylactic treatment strategy to prevent skin cancer development. This information will facilitate identification of those patients at risk for pre-malignant (or pre-cancerous) skin lesions or subsequent NMSC lesions who would benefit from a PD-1/PD-L1 pathway suppressing therapy to prevent skin cancer development. |
| FILED | Friday, December 06, 2019 |
| APPL NO | 17/311538 |
| CURRENT CPC | Peptides C07K 14/705 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017978 | Koralnik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Igor J. Koralnik (Chicago, Illinois); Barbara A. Hanson (Chicago, Illinois); Xin Dang (Burr Ridge, Illinois) |
| ABSTRACT | The invention relates to methods, systems, and components thereof for detecting and discovering viruses in a clinical sample. In particular, the invention relates to methods, systems, and components thereof for detecting and discovering a plurality of viruses in a clinical sample. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/305796 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018759 | PHAL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Yamuna PHAL (Champaign, Illinois); Kevin Lee YEH (Corvallis, Oregon); Rohit BHARGAVA (Urbana, Illinois) |
| ABSTRACT | Methods and apparatus for obtaining a vibrational circular dichroism (VCD) image using a discrete frequency infrared (DFIR) microscope are disclosed. The method includes generating a pulsed laser beam comprising a spectral frequency, which may be tunable; modulating the laser beam to generate circularly polarized light; illuminating a sample and collecting, and detecting an optical signal transmitted or transflected from the location of the sample. The detected signal is demodulated at, for example, both the pulse frequency and the sum or difference of the pulse frequency and the modulating frequency to obtain an intensity value that correspond to the absorbance, and a polarization-dependent value that corresponds to the VCD. Other configurations of the apparatus may be employed to measure VCB and VLD. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/377096 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/108 (20130101) G01J 3/433 (20130101) G01J 3/447 (20130101) G01J 3/2823 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/19 (20130101) Original (OR) Class G01N 21/23 (20130101) G01N 21/39 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018779 | YAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CLEMSON UNIVERSITY (Clemson, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HAI YAO (CLEMSON, South Carolina); TONG YE (CLEMSON, South Carolina); PENG CHEN (CLEMSON, South Carolina); XUN CHEN (CLEMSON, South Carolina) |
| ABSTRACT | Herein are described data acquisition systems and methods applying such systems to determine three-dimensional (3D) diffusion tensors, and simultaneously, to perform 3D structure imaging. Example data acquisition systems can include computing systems in communication with modified light sheet microscopes that are configured for high-speed volumetric imaging to record 3D diffusion processes and high-resolution 3D structural imaging. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/378093 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 21/6486 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 21/008 (20130101) G02B 21/0032 (20130101) G02B 21/0076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018808 | Tao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Shaopeng Wang (Chandler, Arizona); Runli Liang (Mesa, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nongjian Tao (Fountain Hills, Arizona); Shaopeng Wang (Chandler, Arizona); Runli Liang (Mesa, Arizona) |
| ABSTRACT | A system for detecting target molecules includes a sample well defining a sensing region and two electrode regions, a sensor positioned in the sensing region and sensitized to the target molecules, an electrode positioned in each electrode region and configured to expose the sensor to a frequency-modulated electric field, and a detector configured to detect both an amplitude of oscillation of the sensor at a frequency of the modulated electric field and a direction of a displacement of the sensor. The sensing region defines a channel between the electrodes, and a ratio of a current density at a center of the sensing region to a current density at one of the electrodes is at least 2. The system allows detection of target molecules in a normal ionic strength buffer (e.g., having an ionic strength in a range of about 10 mM to about 1 M). |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375231 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 27/44791 (20130101) Original (OR) Class G01N 2021/6439 (20130101) G01N 2201/088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018920 | Stautner |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ernst Wolfgang Stautner (Niskayuna, New York) |
| ABSTRACT | The present disclosure relates to a cooling system that includes a superconducting unit and a reservoir configured to store liquid coolant to cool the superconducting unit. The cooling system also includes an auxiliary storage system that includes one or more storage tanks fluidly coupled to the reservoir. The auxiliary storage system is configured to provide additional coolant to the reservoir as well as receive and store coolant from the reservoir. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 16/928858 |
| CURRENT CPC | Vessels for Containing or Storing Compressed, Liquefied or Solidified Gases; Fixed-capacity Gas-holders; Filling Vessels With, or Discharging From Vessels, Compressed, Liquefied, or Solidified Gases F17C 7/04 (20130101) F17C 2221/017 (20130101) F17C 2227/0337 (20130101) F17C 2270/0536 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3856 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018922 | Shim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); University of Miami (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyunsuk Shim (Atlanta, Georgia); Lee Cooper (Atlanta, Georgia); Saumya Gurbani (Atlanta, Georgia); Andrew Maudsley (Miami, Florida); Sulaiman Sheriff (Miami, Florida) |
| ABSTRACT | Systems and methods provide a parallelized deep learning approach to spectral fitting for magnetic resonance spectroscopy data enabling accurate and rapid spectral fitting and determination of metabolite measurements using a conventional computer. The method may include processing multi-spectra magnetic resonance (MR) spectroscopy data of a region of interest through a series of neural networks. The method may include determining baseline components of each spectrum using a first neural network of the series, generating baseline-corrected components for each spectrum using the baseline components; and determining one or more peak components of each spectrum using a second neural network of the series and the baseline-corrected components. The method may further include determining one or more metabolite measurements of the one or more metabolites in the region of interest using the one or more peak components. |
| FILED | Wednesday, November 20, 2019 |
| APPL NO | 17/295528 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/485 (20130101) Original (OR) Class G01R 33/4625 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019861 | DURR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Nicholas J. DURR (Baltimore, Maryland); Taylor L. BOBROW (Chesapeake, Virginia); Faisal MAHMOOD (Baltimore, Maryland) |
| ABSTRACT | A device may receive a coherent energy illuminated image, of a particular object, that includes laser speckle. The device may process, using a laser speckle reduction model, the coherent energy illuminated image to generate a laser speckle-reduced image. The device may provide the laser speckle-reduced image as output to permit diagnostics based on the laser speckle-reduced image. |
| FILED | Tuesday, October 22, 2019 |
| APPL NO | 17/309100 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6267 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) G06N 3/0454 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220015339 | Maselko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maciej Bozyslaw Maselko (Sydney, Australia); Przemyslaw Bajer (New Brighton, Minnesota); Siba Ranjan Das (Falcon Heights, Minnesota); James Parker (Minneapolis, Minnesota); Michael Joseph Smanski (Falcon Heights, Minnesota); Ambuj Upadhyay (Falcon Heights, Minnesota) |
| ABSTRACT | A system for controlling population of a biological species includes a population of genetically-modified individuals of the biological species, where both males and females in the genetically-modified population carry two mutations. The first mutation is a repressible genetic mutation that results in death of a juvenile individual of the first sex when the juvenile individual of the first sex comprises the repressible lethal mutation and is reared in the absence of a repressor or causes an individual to be sterile when reared in the absence of a repressor. The second mutation is an underdominant genetic mutation. |
| FILED | Tuesday, November 05, 2019 |
| APPL NO | 17/288628 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) Original (OR) Class A01K 67/0333 (20130101) A01K 2217/072 (20130101) A01K 2227/40 (20130101) A01K 2227/706 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016153 | PAINTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EMORY UNIVERSITY (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George R. PAINTER (Atlanta, Georgia); Gregory R. Bluemling (Decatur, Georgia); Michael G. Natchus (Alpharetta, Georgia); David Guthrie (Avondale Estates, Georgia) |
| ABSTRACT | This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds. |
| FILED | Thursday, September 02, 2021 |
| APPL NO | 17/465344 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7068 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016185 | Hsiao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elaine Hsiao (Rowland Heights, California); Sara McBride (Pasadena, California); Sarkis K. Mazmanian (Porter Ranch, California); Paul H. Patterson (Altadena, California) |
| ABSTRACT | Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The bacterial species can include Bacteroides (e.g., B. fragilis, B. thetaiotaomicron, and/or B. vulgatus), and/or Enterococcus (e.g., E. faecalis, E. faecium, E. hirae, E. avium, E. durans, E. gallinarum, or E. casseliflavus). Upon treatment, one or more ASD-related behaviors can be improved in the subject. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/303946 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 35/744 (20130101) Original (OR) Class A61K 2035/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016622 | Hunt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SiO2 Medical Products, Inc. (Auburn, Alabama); Sanaria Inc. (Rockville, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Hunt (Auburn, Alabama); Chase Bryan Jackson (Auburn, Alabama); Eric R. James (Rockville, New York) |
| ABSTRACT | Disclosed are container and cap assemblies for cryogenic storage of materials at temperatures below negative 150° C. The container and cap assemblies disclosed maintain container closure integrity and fluid-tightness at ambient and cryogenic temperatures, optionally to preserve biologically active substances stored therein. |
| FILED | Tuesday, December 17, 2019 |
| APPL NO | 17/309723 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50825 (20130101) Original (OR) Class B01L 2300/042 (20130101) B01L 2300/044 (20130101) B01L 2300/0858 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016760 | KARTALOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emil Paskalev KARTALOV (Pacific Grove, California); Michelangelo COLTELLI (Marina, California); Jeffrey CATTERLIN (Salinas, California) |
| ABSTRACT | A microcapacitor array for providing artificial muscles is described. The microcapacitor array includes a dielectric body with electrode chambers, positive electrodes in positive electrode chambers, the positive electrodes being connected by a first set of channels in the dielectric frame; negative electrodes in negative electrode chambers, the negative electrodes being connected by a second set of channels in the dielectric frame. The first and second set of channels are arranged so that application of a voltage differential between the positive electrodes and the negative electrodes generates an attractive force between each set of adjacent positive and negative electrodes. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/376068 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 9/12 (20130101) B25J 9/1075 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017017 | Mueller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Mueller (Yorktown, Virginia); ALEXANDER ORSI (DAYTON, Ohio); JOHN BALES (BEAVERCREEK, Ohio) |
| ABSTRACT | A firearm rack assembly for securing at least one firearm that is removably attachable to a vehicle. The rack including a rifle attachment assembly, a pistol attachment assembly, an assembly post assembly wherein the rifle attachment assembly and pistol attachment assembly are removably joined to the assembly post and the assembly post is removably attachable to the vehicle. |
| FILED | Sunday, May 23, 2021 |
| APPL NO | 17/327735 |
| CURRENT CPC | Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 7/14 (20130101) Original (OR) Class Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 23/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017063 | Shukla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oshkosh Defense, LLC (Oshkosh, Wisconsin) |
| ASSIGNEE(S) | Oshkosh Defense, LLC (Oshkosh, Wisconsin) |
| INVENTOR(S) | Deepak Shukla (Oshkosh, Wisconsin); Rongjun Zhang (Neenah, Wisconsin); Nader Nasr (Neenah, Wisconsin) |
| ABSTRACT | A drive train for a vehicle includes a first electromagnetic device, a second electromagnetic device electrically coupled to the first electromagnetic device by an electrical power transmission system, and an engine coupled to the first electromagnetic device and configured to drive the first electromagnetic device to provide electrical energy. In all modes of operation where the engine drives the first electromagnetic device to provide the electrical energy, the first electromagnetic device operates without providing the electrical energy to an energy storage device. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492081 |
| CURRENT CPC | Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 6/26 (20130101) B60K 6/34 (20130101) B60K 6/52 (20130101) B60K 6/365 (20130101) B60K 6/387 (20130101) B60K 6/445 (20130101) B60K 6/543 (20130101) Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/11 (20190201) Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 10/02 (20130101) B60W 10/06 (20130101) B60W 10/08 (20130101) B60W 20/10 (20130101) Original (OR) Class B60W 2510/06 (20130101) B60W 2510/08 (20130101) B60W 2510/081 (20130101) B60W 2510/0604 (20130101) B60W 2510/0638 (20130101) B60W 2520/10 (20130101) B60W 2710/06 (20130101) B60W 2710/08 (20130101) B60W 2710/021 (20130101) B60W 2710/083 (20130101) B60W 2710/0644 (20130101) B60W 2710/0677 (20130101) Indexing Scheme Relating to Aspects Cross-cutting Vehicle Technology B60Y 2200/92 (20130101) B60Y 2300/42 (20130101) B60Y 2300/43 (20130101) B60Y 2300/60 (20130101) B60Y 2300/72 (20130101) B60Y 2400/72 (20130101) B60Y 2400/73 (20130101) Gearing F16H 1/28 (20130101) F16H 3/72 (20130101) F16H 3/727 (20130101) F16H 3/728 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/62 (20130101) Y02T 10/92 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 903/91 (20130101) Y10S 903/93 (20130101) Y10S 903/906 (20130101) Y10S 903/914 (20130101) Y10S 903/916 (20130101) Y10S 903/918 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017213 | Parsons |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric S. Parsons (Middlebury, Connecticut) |
| ABSTRACT | A structural member for use in a rotor system which rotates about a rotational axis includes a pin which extends substantially perpendicular to the rotational axis, a filler component positioned adjacent the pin, and a plurality of layers of composite material having fibers oriented lengthwise along a central axis which is perpendicular to the rotational axis. The plurality of fibers in the layers of composite material is wrapped about the pin and the filler component such that the fibers extend along the central axis and the plurality of layers form an opening filled by the filler component and which decreases as a function of distance from the pin along the central axis. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 16/928605 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/33 (20130101) Original (OR) Class B64C 27/48 (20130101) B64C 27/82 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017214 | Orbon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Breen Orbon (New Haven, Connecticut); James McCollough (Fort Worth, Texas); Evan S. Tobin (Newtown, Connecticut); Xiaole Xie (Westport, Connecticut); Jonathan Frydman (New Haven, Connecticut) |
| ABSTRACT | A propeller system for a tail section of an aircraft includes a propeller hub located at the tail section of the aircraft, a plurality of propeller blades mounted to and extending outwardly from the propeller hub, a propeller shaft coupled to the propeller hub and operable to rotate the propeller hub about an axis of rotation, and a propeller gearbox connected to the propeller shaft. The propeller gearbox is fluidly cooled by an airflow within the tail section. A spinner assembly surrounds the propeller hub. The spinner assembly includes at least one outlet opening formed therein downstream from the propeller hub relative to the airflow. The spinner assembly is rotatable to draw the airflow into at least one cooling flow inlet formed in the tail section and across the propeller gearbox to cool the propeller gearbox and out the at least one outlet opening. |
| FILED | Monday, July 20, 2020 |
| APPL NO | 16/933019 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/12 (20130101) B64C 27/46 (20130101) Original (OR) Class B64C 2027/8272 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 13/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017215 | Dunn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Dunn (Trumbull, Connecticut); Keith M. Schenone (Fairfield, Connecticut); Sven R. Lofstrom (Irving, Texas) |
| ABSTRACT | According to an aspect, a method of assembling a mandrel includes assembling a plurality of members via interlocking features arranged at opposing edges of each member of the plurality of members to form a compartment, the assembled members having a collective outer surface that conforms to an inner surface of the spar. A support member is inserted into the compartment formed radially inward from the assembled members, the support member making contact with a portion of each member of the plurality of members. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 16/928453 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) Aeroplanes; Helicopters B64C 27/06 (20130101) B64C 27/473 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017216 | Schmaling et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David N. Schmaling (Southbury, Connecticut); James Breen Orbon (New Haven, Connecticut); Pedro L. Cabrera (West Haven, Connecticut); David H. Hunter (Cheshire, Connecticut); John D. Carroll (Fort Worth, Texas) |
| ABSTRACT | A rotor blade assembly of an aircraft having a rotor hub including a structural member having an inboard end and an outboard end, the structural member being connectable with the rotor hub. A spar surrounds the structural member and extends at least partially along a rotor blade axis. A pitch bearing assembly supports the spar relative to the structural member. The pitch bearing assembly includes an inboard pitch bearing mounted to the inboard end of the structural member and an outboard pitch bearing mounted to the outboard end of the structural member. The rotor blade assembly additionally includes a centrifugal assembly including a centrifugal bearing disposed between the inboard pitch bearing and the outboard pitch bearing relative to the rotor blade axis. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 16/929889 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/10 (20130101) B64C 27/473 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017217 | Cox |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LOCKHEED MARTIN CORPORATION (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John C. Cox (Jupiter, Florida) |
| ABSTRACT | A swashplate assembly of a rotary wing aircraft includes a first component, a second component arranged concentrically with the first component, and a bearing disposed between the first component and the second component. The bearing includes a spherical bearing and at least one bearing roller element and is operable to transmit torque between the first component and the second component. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 16/928626 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/605 (20130101) Original (OR) Class Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/02 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/90 (20130101) F05D 2240/50 (20130101) F05D 2240/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017230 | Speller |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Textron Innovations Inc. (, None) |
| INVENTOR(S) | Charles Hubert Speller (Flower Mound, Texas) |
| ABSTRACT | A clutch that has a synchronizer for matching a rotational velocity of a drive input with a rotational velocity of a driven output prior to engagement of a locking mechanism. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/323547 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 11/28 (20130101) B64C 27/12 (20130101) B64C 27/30 (20130101) B64C 29/0033 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 35/00 (20130101) Original (OR) Class Couplings for Transmitting Rotation; Clutches; Brakes F16D 23/04 (20130101) F16D 23/06 (20130101) F16D 25/061 (20130101) F16D 25/0632 (20130101) F16D 2023/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017238 | Mehra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NOVI LLC (Arlington, Virginia) |
| ASSIGNEE(S) | NOVI LLC (Arlington, Virginia) |
| INVENTOR(S) | Amit Mehra (Arlington, Virginia); Scott Steffan (Hamburg, New York); Evan Sandler (Fairfax, Virginia) |
| ABSTRACT | A process for rapid re-configuration and customization of small satellites using additively manufactured chassis customized to create a more conformal and integrated bus design adapted to a particular payload. The additional components or subsystems of the bus required are are integrated either on the sidewalls of the additively manufactured chassis, or as the sidewalls of such chassis, while the payload is also secured or integrated via custom features that are part of the additively manufactured chassis. Chassis can be rapidly reconfigured in the design stage to adapt to a preferred vendor's application, components and subsystems, or payload specifications, an engineering change to the bus and/or payload, responsive to test data, or the like, thereafter additively manufacturing a new chassis and rapidly producing the entire small satellite. |
| FILED | Sunday, July 11, 2021 |
| APPL NO | 17/372477 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Cosmonautics; Vehicles or Equipment Therefor B64G 1/10 (20130101) Original (OR) Class B64G 1/22 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 12/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017341 | Henderson |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Integrated Solution for Systems, Inc. (Huntsville, Alabama) |
| ASSIGNEE(S) | Integrated Solutions for Systems, Inc. (Huntsville, Alabama) |
| INVENTOR(S) | Robert D. Henderson (Huntsville, Alabama) |
| ABSTRACT | The present disclosure is an autonomous robotic cargo system for moving and accurately positioning cargo inside an aircraft or at any other designated location in an austere environment. The system has a chassis coupled to one or more tracks for moving the chassis from a first location to a second location. The chassis is also coupled to one or more forks for loading cargo and unloading the cargo. In addition, the chassis has a laser scanner positioned on the chassis to capture data indicative of the chassis' environment. The system further has a control processor that pre-generates a preliminary pathway for the chassis to travel from the first location to the second location based upon laser scanner data received from the laser scanner. The control processor also controls the one or more forks to pick up cargo and controls the one or more tracks to move the cargo from the first location to the second location. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 16/930073 |
| CURRENT CPC | Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/063 (20130101) Original (OR) Class B66F 9/0755 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/024 (20130101) G05D 1/027 (20130101) G05D 1/0236 (20130101) G05D 1/0242 (20130101) G05D 2201/0216 (20130101) Image Data Processing or Generation, in General G06T 7/579 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017534 | Lazo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John S. Lazo (Charlottesville, Virginia); Elizabeth Sharlow (Butler, Pennsylvania); Peter Wipf (Pittsburgh, Pennsylvania); Nikhil Tasker (Trumbull, Connecticut); Ettore Rastelli (Pittsburgh, Pennsylvania) |
| ABSTRACT | The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4 A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers. |
| FILED | Tuesday, November 12, 2019 |
| APPL NO | 17/309259 |
| CURRENT CPC | Heterocyclic Compounds C07D 495/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017602 | LAWRENCE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Silk Technologies, Ltd. (Plymouth, Minnesota) |
| ASSIGNEE(S) | Silk Technologies, Ltd. (Plymouth, Minnesota) |
| INVENTOR(S) | Brian D. LAWRENCE (Plymouth, Minnesota); David W. INFANGER (Plymouth, Minnesota); Yue BAI (Plymouth, Minnesota); Nicholas PAULSON (Plymouth, Minnesota) |
| ABSTRACT | A biotherapeutic ophthalmic solution that may include a silk-derived protein as an active ingredient. The specific formulation of an ophthalmic composition is critical to meeting user requirements, to the delivery of dosage forms, and to maintaining product stability. The formulations described herein are ophthalmic solutions that are comfortable to the user while product stability is maintained, even after long-term storage. Numerous excipients, manufacturing processes, and container closures were evaluated for their ability to stabilize silk-derived protein under ambient and accelerated conditions. Analyses showed that only a very small subset of vehicle formulations were able to meet the high physiochemical property standards required for stabilizing protein-containing therapeutic ophthalmic solution formulations. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/377159 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 47/183 (20130101) Peptides C07K 14/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017604 | Ellebedy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Ali Ellebedy (St. Louis, Missouri); Aaron Schmitz (St. Louis, Missouri); Jackson Turner (St. Louis, Missouri); Wafaa Al Soussi (St. Louis, Missouri); Michael Diamond (St. Louis, Missouri); Daved Fremont (St. Louis, Missouri); James Brett Case (St. Louis, Missouri); Haiyan Zhao (St. Louis, Missouri); Adrianus Boon (St. Louis, Missouri); Sean Whelan (St. Louis, Missouri); Andrew McCluskey (Holden, Massachusetts); Christopher Negron (Worcester, Massachusetts) |
| ABSTRACT | The present invention relates to antibodies or antigen-binding fragments that are useful for treating coronavirus infections (e.g., COVID-19 caused by SARS-CoV-2). The present invention also relates to various pharmaceutical compositions and methods of treating coronavirus using the antibodies or antigen-binding fragments. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/232796 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018045 | Lundin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia); The United States of America, as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Jeffrey G. Lundin (Burke, Virginia); Justin Ryan, III (Chapel Hill, North Carolina); Riccardo Casalini (Hyattsville, Maryland); Joshua Alan Orlicki (Havre de Grace, Maryland) |
| ABSTRACT | Disclosed herein are fibers having a polymer, such as a textile polymer, and an insect repellant, such as picaridin. The fiber may have a core of the polymer and repellant surrounded by a sheath of the polymer. The fiber may be made by electrospinning a solution of the polymer and the repellant. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/377795 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/34 (20130101) A01N 43/40 (20130101) Crimping or Curling Fibres, Filaments, Threads, or Yarns; Yarns or Threads D02G 3/36 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2331/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018377 | Travis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (, None) |
| INVENTOR(S) | Robert D. Travis (Tucson, Arizona); Justin Powell (Tucson, Arizona) |
| ABSTRACT | A frangible detent pin comprising a base a pin head and an elastic member. The base is configured to be secured within a bore. The pin head and the base are interconnected through a frangible connection. The elastic member is configured to bias the pin head away from the base. The frangible detent pin has a rigid stage in which the pin head is rigidly positioned relative to the base and a spring-loaded stage in which the pin head is moveable relative to the base under a compression load between pin head and the base. The frangible detent pin is configured to transition from the rigid stage to the spring-loaded stage in response to the compression load exceeding a predetermined threshold sufficient to cause the frangible connection to fail. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 16/930233 |
| CURRENT CPC | Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 19/002 (20130101) F16B 31/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018624 | Seghi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Steven Seghi (Bloomington, Indiana); Kevin Kellar (Crane, Indiana) |
| ABSTRACT | The invention relates to quick acting interfaces that allow for easier transportation and maintenance of precision rifles. Embodiments include an interface with an engaging segment and a receiving segment that engage one another and lock together. The engaging segment may have a series of connective bearings that fit into indentations inside the receiving segment. Embodiments allow a firearm to be modulated such that a barrel of the firearm may be disassembled without the need of any specialized equipment and reassembled without impacting the firearm's accuracy or reliability. Embodiments are scalable such that multiple interfaces can be used to adjust the total length of the firearm barrel. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/202819 |
| CURRENT CPC | Functional Features or Details Common to Both Smallarms and Ordnance, e.g Cannons; Mountings for Smallarms or Ordnance F41A 21/482 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018746 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Flex Ltd. (Singapore, Singapore) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weifeng Liu (Dublin, California); Jesus A. Tan (Fremont, California); William L. Uy (San Jose, California); Dongkai Shangguan (San Jose, California) |
| ABSTRACT | Methods, devices, and systems for testing the flexibility of a sample such as an electronic device are provided herein. A testing system can have a motor operably connected to a mandrel such that the motor causes the mandrel to accurately and precisely rotate and cause the sample to conform to an outer surface of the mandrel. Moreover, a proximal end of the sample is secured to the outer surface of the mandrel, and the opposing distal end is controlled by a retractable holder such that the entire sample is subjected to a constant bend radius as the mandrel rotates. Other aspects and features such as controlling the environment around the mandrel and securing small samples to the mandrel are also described herein. |
| FILED | Wednesday, October 07, 2020 |
| APPL NO | 17/065403 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/02 (20130101) G01N 3/20 (20130101) Original (OR) Class G01N 2203/0023 (20130101) G01N 2203/0037 (20130101) G01N 2203/0058 (20130101) G01N 2203/0222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018786 | Wilson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of the Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebekah C Wilson (Mahomet, Illinois); Benjamin C Masters (Urbana, Illinois) |
| ABSTRACT | Disclosed are methods that, by not physically touching a material being measured, can measure the material's differential response quite accurately. A collimated light shines on the material under test, is reflected off it, and is then captured by a device that records the position where the reflected light is captured. This process is done both before and after the material is processed in some way (e.g., by applying a coat of paint). The change in position where the reflected light is captured is used in calculating the deflection of the material as induced b the process. This measured induced deflection is then used to accurately determinate the stress introduced into the material by the process. Other characteristics of the material under test, such as aspects of the material composition of a bi-metallic strip, for example, may also be determined from a deflection measurement. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/488320 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/24 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/86 (20130101) Original (OR) Class G01N 21/8422 (20130101) G01N 2021/8438 (20130101) G01N 2021/8636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019020 | Popovic |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milos A. Popovic (Boulder, Colorado) |
| ABSTRACT | A grating coupler couples a waveguide to a beam and is formed of patterned shapes in a first and second layer of planar material, the shapes embedded in background material, the layers separated by less than one wavelength. The shapes are organized as a plurality of adjacent unit cells arranged along a direction of propagation of light with each unit cell including a shape of the first material and a shape of the second material, each unit cell having design parameters including a period, a width wb of the shape of first planar material, a width wt of the shape of second planar material, and an offset between the shapes. The coupler has a directivity ratio D is at least 10 dB between “up” and “down” radiation; and unit cells differ in at least one parameter selected from period, wb, wt, and offset to provide a predetermined beam shape. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/232677 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/34 (20130101) G02B 6/124 (20130101) Original (OR) Class G02B 6/305 (20130101) G02B 6/1228 (20130101) G02B 27/4266 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019048 | Hall et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harris J Hall (Yellow Springs, Ohio); David Torres Reyes (Mason, Ohio); Michael E McConney (Dayton, Ohio) |
| ABSTRACT | A tunable optical filter for a detector is presented including a plate having a top side and a bottom side. The plate has material properties making it transparent to a range of optical frequencies. A transparent metasurface is proximate the top side of the plate. The transparent metasurface is configured to have a transmissive pass band and a stop band. An undercarriage support structure is proximate the bottom side of the plate. The undercarriage support is responsive to photothermal heating. The undercarriage support is configured to deform from the photothermal heating caused by an undesired signal thereby shifting the stop band in frequency toward the undesired signal to block reception of the undesired signal by the detector. |
| FILED | Monday, July 20, 2020 |
| APPL NO | 16/933078 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/29359 (20130101) G02B 7/008 (20130101) Original (OR) Class G02B 7/1815 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019514 | Gu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ronghui Gu (New York, New York); Jason Nieh (New York, New York); Runzhou Tao (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronghui Gu (New York, New York); Jason Nieh (New York, New York); Runzhou Tao (New York, New York) |
| ABSTRACT | Mechanisms for proving the correctness of software on relaxed memory hardware are provided, the mechanisms comprising: receiving a specification, a hardware model, and an implementation for the software to be executed on the relaxed memory hardware; evaluating the software using a sequentially consistent hardware model; evaluating the software using a relaxed memory hardware model and at least one of the following conditions: a data-race-free (DRF)-kernel condition; a no-barrier-misuse condition; a memory-isolation condition; a transactional-page-table condition; a write-once-kernel-mapping condition; and a weak-memory-isolation condition; and outputting an indication of whether the software is correct based on the evaluating the software using the sequentially consistent hardware model and the evaluating the software using the relaxed memory hardware model. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/376120 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/3604 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019545 | BERTACCO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| INVENTOR(S) | Valeria BERTACCO (Ann Arbor, Michigan); Abraham ADDISIE (Ann Arbor, Michigan) |
| ABSTRACT | The increased use of graph algorithms in diverse fields has highlighted their inefficiencies in current chip-multiprocessor (CMP) architectures, primarily due to their seemingly random-access patterns to off-chip memory. Here, a novel computer memory architecture is proposed that processes operations on vertex data in on-chip memory and off-chip memory. The hybrid computer memory architecture utilizes a vertex's degree as a proxy to determine whether to process related operations in on-memory or off-chip memory. The proposed computer memory architecture manages to provide up to 4.0× improvement in performance and 3.8× in energy benefits, compared to a baseline CMP, and up to a 2.0× performance boost over state-of-the-art specialized solutions. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 16/932183 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/1668 (20130101) Original (OR) Class G06F 13/4027 (20130101) G06F 13/4282 (20130101) G06F 16/9558 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019580 | Mirhaji |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Parsa Mirhaji (Pearland, Texas) |
| ABSTRACT | Embodiments of methods and systems for informatics systems are disclosed. Such informatics systems may utilize a unifying format to represent text to facilitate linking between data from the text and one or more ontologies, and the commensurate ability to mine such data. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/489533 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/22 (20190101) G06F 16/248 (20190101) G06F 16/367 (20190101) G06F 16/2465 (20190101) Original (OR) Class G06F 16/3329 (20190101) G06F 16/3344 (20190101) G06F 16/9024 (20190101) G06F 40/211 (20200101) G06F 40/253 (20200101) G06F 40/284 (20200101) G06F 40/289 (20200101) Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019657 | Sethumadhavan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lakshminarasimhan Sethumadhavan (Niskayuna, New York); Miguel Arroyo (New York, New York); Mohamed Tarek Bnziad Mohamed Hassan (New York, New York); Evgeny Manzhosov (New York, New York) |
| ABSTRACT | Disclosed are methods, systems, devices, media, circuits, and other implementations, including a method that includes generating for a code block of a process executing on a controller-based device one or more code block copies defined in a virtual address space of the controller-based device, with the code block of the process being stored in a particular segment of a physical address space of the controller-based device, and with the code block configured to separately map to each of the one or more of the code block copies in the virtual address space. The method further includes processing at least a portion of one of the one or more code block copies defined in the virtual address space when the corresponding code block of the process is to be processed. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/030785 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/53 (20130101) G06F 21/54 (20130101) Original (OR) Class G06F 2221/2135 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019716 | Kiarashinejad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yashar Kiarashinejad (Atlanta, Georgia); Sajjad Abdollahramezani (Atlanta, Georgia); Ali Adibi (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yashar Kiarashinejad (Atlanta, Georgia); Sajjad Abdollahramezani (Atlanta, Georgia); Ali Adibi (Atlanta, Georgia) |
| ABSTRACT | Disclosed are systems and method for enhanced engineering design and optimization incorporating double-step dimensionality-reduction in order to provide customized, automated solutions to the design and optimization of electromagnetic nanostructures. The system can train a multi-stage neural network reduce the response space of a design problem. The system can train a second neural network to reduce the design space of the design problem. As a result of these reductions, the system can generate a one-to-one relationship between the design and response spaces of complex design problems. The system can subsequently solve both the forward design and the inverse problem. Additionally, the system can utilize the generated neural networks to determine a plurality of analytical relationships between the design space and the response space. The system can then utilize the determined relationship to arrive at optimal design solutions. |
| FILED | Wednesday, November 20, 2019 |
| APPL NO | 17/294837 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/27 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) G06N 3/088 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019787 | Diienno |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Diienno (Avondale, Pennsylvania) |
| ABSTRACT | Various embodiments are described that relate to classification of an unknown object. A time series signal associated with an unknown object can be obtained from a sensor. The time series signal can be subjected to a transform set, such as a Fourier transform and a discrete cosine transform, to produce a transform outcome. Based, at least in part, on the transform outcome, the unknown object can be classified. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 16/928280 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/147 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00536 (20130101) Original (OR) Class G06K 9/6202 (20130101) G06K 9/6268 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220020635 | Mohseni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hooman Mohseni (Wilmette, Illinois); Simone Bianconi (Evanston, Illinois) |
| ABSTRACT | Methods for creating a conductive feature in a dielectric material are provided. In an embodiment, such a method comprises irradiating a region of a dielectric material having a resistivity of at least 108 W cm with a focused ion beam, the irradiated region corresponding to a conductive feature embedded in the dielectric material, the conductive feature having a conductivity greater than that of the dielectric material; and forming one or more contact pads of a conductive material in electrical communication with the conductive feature, the one or more contact pads configured to apply a voltage across the conductive feature using a voltage source. |
| FILED | Thursday, November 07, 2019 |
| APPL NO | 17/293276 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/42 (20130101) H01L 21/76823 (20130101) Original (OR) Class H01L 21/76825 (20130101) H01L 21/76843 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220020914 | Shabani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NEW YORK UNIVERSITY (New York, New York) |
| ASSIGNEE(S) | NEW YORK UNIVERSITY (New York, New York) |
| INVENTOR(S) | Javad Shabani (Briarcliff Manor, New York); Matthieu C. Dartiailh (New York, New York) |
| ABSTRACT | The method of performing braiding operations can include providing a first Josephson junction including first gates. The method can include providing a second Josephson junction including second gates. The method can include tuning the first gates to dispose a first pair of Majorana fermions a first region. The method can include tuning the second gates to dispose a second pair of Majorana fermions in a second region. The method can include tuning the first gates to dispose a first Majorana fermion in the first region and to dispose a second Majorana fermion in a third region. The method can include tuning the second gates to dispose a third Majorana fermion in a fourth region and to dispose a fourth Majorana fermion in the second region. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/378375 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/223 (20130101) Original (OR) Class H01L 39/228 (20130101) H01L 39/2493 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220020942 | Colbert et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Adam E. Colbert (Alexandria, Virginia); Diogenes Placencia (Alexandria, Virginia); Janice E. Boercker (Fairfax, Virginia); Edward E. Aifer (Arlington, Virginia); Joseph G. Tischler (Alexandria, Virginia); Erin L. Ratcliff (Tucson, Arizona) |
| ABSTRACT | Photodiodes configured to convert incident photons in the short-wave infrared (SWIR) to electric current, where the photodiodes have a PbS/PbClx core/shell nanocrystal absorber layer. The PbClx shell in the PbS/PbClx nanocrystals provide native passivation in the (100) crystal facets and enable removal of native ligands and ligand exchange on the (111) crystal facets of the PbS/PbClx nanocrystals such that the photodiode exhibits reduced current densities under reverse bias and greater infrared photoresponse, providing improved device performance as compared to photodiodes having absorber layers formed from PbS core nanocrystals alone. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375050 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0077 (20130101) H01L 51/426 (20130101) H01L 51/447 (20130101) Original (OR) Class H01L 51/4293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220021216 | Perry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | N. Christopher Perry (Manchester, New Hampshire); Stewart M. Coulter (Bedford, New Hampshire); Thomas A. Doyon (Manchester, New Hampshire) |
| ABSTRACT | A system for powering a device is disclosed. The system includes at least one internal battery located in a device, at least one external battery connected to the device, and a master controller configured to connect either the at least one internal battery or the at least one external battery to a power bus to power the device. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/491660 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/382 (20190101) Electric Digital Data Processing G06F 1/263 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/425 (20130101) H01M 10/482 (20130101) H01M 10/4207 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/38 (20130101) Original (OR) Class H02J 7/0013 (20130101) H02J 7/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220021391 | PASANDI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ghasem PASANDI (Los Angeles, California); Massoud PEDRAM (Beverly Hills, California) |
| ABSTRACT | An SFQ circuit system includes at least one SFQ block having a plurality of SFQ logic gates. Characteristically, at least a portion of the SFQ logic gates are arranged in series. The SFQ circuit system includes a timing system configured to provide a first set of inputs and collect a first set of outputs of the at least one SFQ block at a rate defined by a slow clock frequency while the SFQ logic gates are clocked at a fast clock frequency. Advantageously, the rate is sufficiently slow to allow the first set of inputs to propagate through all levels of the SFQ logic gates to produce the first set of outputs of the at least one SFQ block without colliding with a second set of inputs to the at least one SFQ block. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/221998 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Pulse Technique H03K 19/20 (20130101) H03K 19/096 (20130101) H03K 19/195 (20130101) Original (OR) Class H03K 19/17744 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220021464 | Beun |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Josh Beun (Alexandria, Virginia) |
| ABSTRACT | A finite rate of innovation (FRI) communications system includes a reference signal generator, an FRI modulator configured to apply an FRI kernel and encode information onto the reference signal, and a transmitter configured to transmit the encoded signal. The FRI kernel is one of a sinc function kernel or a Gaussian kernel. A receiver unit is configured to receive an encoded signal, convert the encoded signal into a digital signal, and demodulate and recover information from finite rate of innovation parameters in the digital signal. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/376083 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/548 (20130101) Transmission H04B 10/50 (20130101) H04B 10/60 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220021620 | Halepovic et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AT and T INTELLECTUAL PROPERTY I, L.P. (Atlanta, Georgia); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emir Halepovic (Somerset, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Muhammad Usama Chaudhry (Milpitas, California); Shanyu Zhou (Chicago, Illinois); Balajee Vamanan (Chicago, Illinois); Hulya Seferoglu (Chicago, Illinois) |
| ABSTRACT | In various aspects, a system that comprises detecting a congestion event in a network that transmits a first group of data packets and a second group of data packets, wherein the detecting the congestion event comprises detecting the congestion event has initiated in response to a data packet throughput value of the network having been determined to have decreased below a threshold value; in response to the detecting of the congestion event, determine a transmission rate of the second group of data packets based on a transmission priority of the second group of data packets; determining a data packet dropping rate for the second group of data packets based on the transmission rate of the second group of data packets and a size of the first group of data packets and transmitting the second group of data packets utilizing the transmission rate and the data packet dropping rate. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492351 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/062 (20130101) H04L 43/0829 (20130101) H04L 43/0894 (20130101) H04L 47/24 (20130101) Original (OR) Class H04L 47/6215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220021710 | Eskridge et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts); Florida Institute of Technology, Inc. (Melbourne, Florida) |
| ASSIGNEE(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts); Florida Institute of Technology, Inc. (Melbourne, Florida) |
| INVENTOR(S) | Thomas C. Eskridge (Satellite Beach, Florida); Marco M. Carvalho (Satellite Beach, Florida); Brett Benyo (Ayer, Massachusetts); Michael Atighetchi (Framingham, Massachusetts); Fusun Yaman (Arlington, Massachusetts) |
| ABSTRACT | A decision engine includes: a genetic algorithm framework including a knowledge base of standard configurations, a candidate selector generator and a selector to select a candidate configuration from a plurality of preferred standard configurations in response to the candidate selector generator; a parallelized reasoning framework including an attack surface reasoning algorithm module to compute the security and cost tradeoffs of an attack surface associated with each candidate configuration; and a user interface framework including a web service engine where users can interact and provide feedback on direction of an evolution used in a genetic algorithm search for evolving defenses. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375580 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2423 (20190101) Computer Systems Based on Specific Computational Models G06N 3/126 (20130101) G06N 5/022 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 41/08 (20130101) H04L 41/22 (20130101) H04L 63/20 (20130101) Original (OR) Class H04L 63/1433 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220022044 | D'ORO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Salvatore D'ORO (Allston, Massachusetts); Tommaso MELODIA (Newton, Massachusetts); Francesco RESTUCCIA (Boston, Massachusetts); Leonardo BONATI (Boston, Massachusetts) |
| ABSTRACT | Methods and systems are provided for allocating resources to users in a wireless network including a plurality of edge nodes that provide wireless network access and multi-access edge computing functions. Slice requests are received from the users for a type of resource, including one or more of networking resources, storage resources, and computation resources. A set of slice requests to be admitted is determined based on resource availability constraints among one or more of the networking resources, the storage resources, and the computation resources at each edge node. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 17/365070 |
| CURRENT CPC | Wireless Communication Networks H04W 4/021 (20130101) H04W 16/10 (20130101) Original (OR) Class H04W 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220022287 | Pirlo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Russell Kirk Pirlo (Oakwood, Ohio); Joel D. Gaston (Alexandria, Virginia) |
| ABSTRACT | A device having: an article having a flat surface and a lower surface opposed to the flat surface; a cavity formed in the lower surface forming a complete loop surrounding a central portion of the article; a heating element having the same shape as the complete loop in the cavity and positioned to warm a portion of the flat surface adjacent to the heating element when the heating element is activated; a cooling device positioned to cool a portion of the flat surface in the central portion; and a release layer on the flat surface. A device having: an article having an upper surface; a heating element on the upper surface forming a complete loop surrounding a central portion of the article; and an electrically insulating material on the upper surface within the central portion. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/488738 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0015 (20130101) D01D 5/0061 (20130101) D01D 5/0076 (20130101) Electric Heating; Electric Lighting Not Otherwise Provided for H05B 3/40 (20130101) Original (OR) Class H05B 3/64 (20130101) H05B 2213/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220015500 | Pretzer-Aboff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ingrid Pretzer-Aboff (Newark, Delaware); Richard D. Martin (Newark, Delaware); David Bruce Chase (Newark, Delaware); Scott Jones (Newark, Delaware); John F. Rabolt (Greenville, Delaware) |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware) |
| INVENTOR(S) | Ingrid Pretzer-Aboff (Newark, Delaware); Richard D. Martin (Newark, Delaware); David Bruce Chase (Newark, Delaware); Scott Jones (Newark, Delaware); John F. Rabolt (Greenville, Delaware) |
| ABSTRACT | A device adapted to be secured to the foot of a user includes one or more vibration actuators configured to provide vibrations to the user's foot, one or more force or acceleration sensors configured to sense forces or acceleration exerted by the user's foot, and a controller configured to operate the vibration actuators in a continuous mode to provide intermittent vibration to the user's foot independent of information sensed by the force or acceleration sensors. The vibration includes a first period of continuous vibration followed by a second period of no vibration followed by a third period of continuous vibration. The device may also be configured to operate in a feedback mode. |
| FILED | Thursday, December 12, 2019 |
| APPL NO | 17/413337 |
| CURRENT CPC | Characteristic Features of Footwear; Parts of Footwear A43B 3/0005 (20130101) A43B 7/147 (20130101) Original (OR) Class Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 3/00 (20130101) A61H 23/02 (20130101) A61H 2201/165 (20130101) A61H 2201/1642 (20130101) A61H 2201/5061 (20130101) A61H 2201/5084 (20130101) A61H 2201/5097 (20130101) A61H 2205/12 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220015832 | DiMaio et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intuitive Surgical Operations, Inc. (Sunnyvale, California); The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simon P. DiMaio (San Carlos, California); Christopher J. Hasser (Los Altos, California); Russell H. Taylor (Severna Park, Maryland); David Q. Larkin (Menlo Park, California); Peter Kazanzides (Towson, Maryland); Anton Deguet (Baltimore, Maryland); Balazs Peter Vagvolgyi (Baltimore, Maryland); Joshua Leven (San Francisco, California) |
| ABSTRACT | A minimally invasive surgical system is disclosed including a processor coupled to a stereoscopic endoscope and a stereoscopic video display device. The processor generates an operative image of an anatomic structure in the surgical site, overlays the operative image onto the captured stereo video images for display on the stereoscopic video display device, generates and overlays a pointer onto the operative image or the captured stereo video images to display the pointer on the stereoscopic video display device with a three dimensional appearance, and switches between a first mode for input devices of a surgeon console used to couple motion into surgical instruments and a second mode used to control an interactive graphical user interface to allow interactions with the pointer and the operative image in three dimensions using input devices having at least three degrees of freedom. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/468198 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00193 (20130101) A61B 8/00 (20130101) A61B 8/12 (20130101) A61B 8/4245 (20130101) A61B 34/10 (20160201) Original (OR) Class A61B 34/30 (20160201) A61B 34/37 (20160201) A61B 34/70 (20160201) A61B 34/71 (20160201) A61B 34/76 (20160201) A61B 2017/00203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016612 | Zhao |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Zhao (Ames, Iowa) |
| ABSTRACT | The disclosure relates to molecularly-imprinted cross-linked micelles that can selectively hydrolyze carbohydrates. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/368257 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/067 (20130101) Original (OR) Class B01J 35/0013 (20130101) B01J 37/04 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) Polysaccharides; Derivatives Thereof C08B 15/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016626 | Chiou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Pei-Yu E. Chiou (Los Angeles, California); Kuo-Wei Huang (Los Angeles, California); Igor Y. Khandros (Orinda, California); Ming C. Wu (Moraga, California) |
| ABSTRACT | Microfluidic devices in which electrokinetic mechanisms move droplets of a liquid or particles in a liquid are described. The devices include at least one electrode that is optically transparent and/or flexible. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401478 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2300/123 (20130101) B01L 2300/165 (20130101) B01L 2400/0415 (20130101) B01L 2400/0424 (20130101) B01L 2400/0427 (20130101) B01L 2400/0638 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 5/005 (20130101) B03C 5/026 (20130101) B03C 2201/26 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017418 | Akono et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ange-Therese Akono (Evanston, Illinois); Jiaxin Chen (Evanston, Illinois) |
| ABSTRACT | Methods for the dispersion and synthesis of multi-walled carbon nanotube-cement composites with high concentrations of multi-walled carbon nanotubes that do not require chemical dispersion aids or dispersion-enhancing chemical surface functionalization are provided. Also provided are multi-walled carbon nanotube-cement composites made using the methods. Methods for the dispersion and synthesis of carbon nanofiber-cement composites with high concentrations of carbon nanofibers that do not require chemical dispersion aids or dispersion-enhancing chemical surface functionalization are further provided. Also provided are carbon nanofiber-cement composites made using the methods. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/376426 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/026 (20130101) C04B 14/386 (20130101) C04B 28/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017556 | Pemberton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (TUCSON, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| INVENTOR(S) | Jeanne E. Pemberton (Tucson, Arizona); Tyler Roberts (Tucson, Arizona) |
| ABSTRACT | The present disclosure discusses methods for producing stereoisomerically enriched carbohydrate-based surfactants. In particular, methods of the invention include producing stereoisomerically enriched hydrophobic portion of the carbohydrate-based surfactants. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/489477 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 3/003 (20130101) C07F 9/94 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 1/00 (20130101) C07H 15/04 (20130101) C07H 15/06 (20130101) C07H 15/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018060 | Subramaniam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anand Bala Subramaniam (Merced, California); Joseph Pazzi (Merced, California); Vaishnavi Girish (Merced, California) |
| ABSTRACT | Methods and compositions for rapid and efficient assembly of fibers coated with lamellar vesicles are provided. Cosmetic and therapeutic uses of vesicle-coated fibers are also provided. |
| FILED | Thursday, November 14, 2019 |
| APPL NO | 17/293905 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 9/1273 (20130101) A61K 9/1277 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 13/203 (20130101) D06M 15/647 (20130101) D06M 23/02 (20130101) Original (OR) Class Pulp Compositions; Preparation Thereof Not Covered by Subclasses D21C or D21D; Impregnating or Coating of Paper; Treatment of Finished Paper Not Covered by Class B31 or Subclass D21G; Paper Not Otherwise Provided for D21H 19/82 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018826 | Rege et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); BANNER HEALTH (Phoenix, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); BANNER HEALTH (Phoenix, Arizona) |
| INVENTOR(S) | Kaushal Rege (Chandler, Arizona); Karthik Subramaniam Pushpavanam (Tempe, Arizona); Eshwaran Narayanan (Tempe, Arizona); Stephen Sapareto (Apache Junction, Arizona); John C. Chang (Gilbert, Arizona) |
| ABSTRACT | An apparatus includes a solution including a metallic compound, a surfactant, and an acid. The solution is substantially colorless. A container holds the solution. A radiated solution is formed when the solution receives a low dose of ionizing radiation |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357138 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/02 (20130101) G01N 33/48 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019020 | Popovic |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Milos A. Popovic (Boulder, Colorado) |
| ABSTRACT | A grating coupler couples a waveguide to a beam and is formed of patterned shapes in a first and second layer of planar material, the shapes embedded in background material, the layers separated by less than one wavelength. The shapes are organized as a plurality of adjacent unit cells arranged along a direction of propagation of light with each unit cell including a shape of the first material and a shape of the second material, each unit cell having design parameters including a period, a width wb of the shape of first planar material, a width wt of the shape of second planar material, and an offset between the shapes. The coupler has a directivity ratio D is at least 10 dB between “up” and “down” radiation; and unit cells differ in at least one parameter selected from period, wb, wt, and offset to provide a predetermined beam shape. |
| FILED | Friday, April 16, 2021 |
| APPL NO | 17/232677 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/34 (20130101) G02B 6/124 (20130101) Original (OR) Class G02B 6/305 (20130101) G02B 6/1228 (20130101) G02B 27/4266 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019434 | Gu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Gu (Evanston, Illinois); Zhengyu Chen (Evanston, Illinois) |
| ABSTRACT | Systems and/or methods can include a ring based inverter chain that constructs multi-bit flip-flops that store time. The time flip-flops serve as storage units and enable pipeline operations. Single cells used in time series analysis, such as dynamic time warping are rendered by the time-domain circuits. The circuits include time flip-flops, Min, and ABS circuits. A and the matrix can be constructed through the single cells. |
| FILED | Wednesday, December 18, 2019 |
| APPL NO | 17/311849 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/605 (20130101) G06F 9/3001 (20130101) G06F 9/3555 (20130101) G06F 9/30029 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019441 | Rosing et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tajana Simunic Rosing (San Diego, California); Justin Morris (San Diego, North Carolina); Mohsen Imani (San Diego, California); Yeseong Kim (La Jolla, California); John Messerly (Danville, California); Yunhui Guo (San Diego, California); Behnam Khaleghi (La Jolla, California); Saransh Gupta (La Jolla, California); Sahand Salamat (San Diego, California); Joonseop Sim (San Diego, California) |
| ABSTRACT | A hyperdimensional processing system can be configured to process hyperdimensional (HD) data, where the system can include a CPU configured to receive compiled binary executable data including CPU native instructions and hyperdimensional processing unit (HPU) native instructions, wherein the CPU is configured to store the CPU native instructions in a main memory coupled to the CPU for retrieval and execution by the CPU, the CPU further configured to forward the HPU native instructions to a HPU. The HPU can be configured to receive HPU native instructions native instructions and to store the HPU native instructions in a hyperdimensional memory coupled to the HPU for retrieval and execution by the CPU. Other aspects and embodiments according to the present invention are also disclosed herein. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/376105 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3836 (20130101) Original (OR) Class G06F 9/30036 (20130101) Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Static Stores G11C 13/0026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019514 | Gu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ronghui Gu (New York, New York); Jason Nieh (New York, New York); Runzhou Tao (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronghui Gu (New York, New York); Jason Nieh (New York, New York); Runzhou Tao (New York, New York) |
| ABSTRACT | Mechanisms for proving the correctness of software on relaxed memory hardware are provided, the mechanisms comprising: receiving a specification, a hardware model, and an implementation for the software to be executed on the relaxed memory hardware; evaluating the software using a sequentially consistent hardware model; evaluating the software using a relaxed memory hardware model and at least one of the following conditions: a data-race-free (DRF)-kernel condition; a no-barrier-misuse condition; a memory-isolation condition; a transactional-page-table condition; a write-once-kernel-mapping condition; and a weak-memory-isolation condition; and outputting an indication of whether the software is correct based on the evaluating the software using the sequentially consistent hardware model and the evaluating the software using the relaxed memory hardware model. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/376120 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/3604 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220020896 | Brown et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wright State University (Dayton, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elliott R. Brown (Beavercreek, Ohio); Weidong Zhang (Cary, North Carolina); Tyler Growden (Dublin, Ohio); Paul Berger (Columbus, Ohio) |
| ABSTRACT | A unipolar-doped light emitting diode or laser diode is described. The diode includes a bottom region having an n-type layer, a top region having an n-type layer, and a middle region between the top and bottom regions having at least one material different from the top or bottom region forming two or more heterojunctions. The top and bottom regions create light emission by interband tunneling-induced photon emission. Systems including the unipolar-doped diode including LIDAR are also taught. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/083286 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) H01L 33/0025 (20130101) Original (OR) Class H01L 33/0029 (20130101) H01L 33/145 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/347 (20130101) H01S 5/0657 (20130101) H01S 5/34313 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220021110 | Yoon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong-Kyu Yoon (Gainesville, Florida); Seahee Hwangbo (Gainesville, Florida) |
| ABSTRACT | Various examples are provided for meander line (ML) slots, which can be used for mutual coupling reduction. In one example, an antenna array includes first and second patch antenna elements disposed on a first side of a substrate, the first and second patch antenna elements separated by a gap. The antenna array can include a meander line (ML) slot formed in a ground plane disposed on a second side of the substrate. A plurality of ML slots can be aligned with the gap between the first and second patch antenna elements. In another example, a method includes forming first and second antenna elements on a first side of a substrate and forming a ML slot in a ground plane disposed on a second side of the substrate aligned with a gap between the first and second antenna elements. |
| FILED | Monday, May 10, 2021 |
| APPL NO | 17/315964 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/52 (20130101) H01Q 1/523 (20130101) Original (OR) Class H01Q 3/00 (20130101) H01Q 9/0407 (20130101) H01Q 21/06 (20130101) H01Q 21/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220021620 | Halepovic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AT and T INTELLECTUAL PROPERTY I, L.P. (Atlanta, Georgia); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emir Halepovic (Somerset, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Muhammad Usama Chaudhry (Milpitas, California); Shanyu Zhou (Chicago, Illinois); Balajee Vamanan (Chicago, Illinois); Hulya Seferoglu (Chicago, Illinois) |
| ABSTRACT | In various aspects, a system that comprises detecting a congestion event in a network that transmits a first group of data packets and a second group of data packets, wherein the detecting the congestion event comprises detecting the congestion event has initiated in response to a data packet throughput value of the network having been determined to have decreased below a threshold value; in response to the detecting of the congestion event, determine a transmission rate of the second group of data packets based on a transmission priority of the second group of data packets; determining a data packet dropping rate for the second group of data packets based on the transmission rate of the second group of data packets and a size of the first group of data packets and transmitting the second group of data packets utilizing the transmission rate and the data packet dropping rate. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492351 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/062 (20130101) H04L 43/0829 (20130101) H04L 43/0894 (20130101) H04L 47/24 (20130101) Original (OR) Class H04L 47/6215 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220021887 | Banerjee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suman Banerjee (Madison, Wisconsin); Peng Liu (Cupertino, California); Varun Chandrasekaran (Madison, Wisconsin) |
| ABSTRACT | A video compression/decompression system employs a machine learning model to extract regions of interest from the input video to define relatively higher bit rate portions of the video frames that are transmitted. The resulting compressed data may be transmitted using standard protocols without specialized decoders but may optionally include a second machine learning model trained at the transmitter to boost the resolution of the reconstructed compressed data emphasizing the region of interest. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 16/928690 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Pictorial Communication, e.g Television H04N 19/146 (20141101) H04N 19/167 (20141101) Original (OR) Class H04N 19/176 (20141101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220022044 | D'ORO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Salvatore D'ORO (Allston, Massachusetts); Tommaso MELODIA (Newton, Massachusetts); Francesco RESTUCCIA (Boston, Massachusetts); Leonardo BONATI (Boston, Massachusetts) |
| ABSTRACT | Methods and systems are provided for allocating resources to users in a wireless network including a plurality of edge nodes that provide wireless network access and multi-access edge computing functions. Slice requests are received from the users for a type of resource, including one or more of networking resources, storage resources, and computation resources. A set of slice requests to be admitted is determined based on resource availability constraints among one or more of the networking resources, the storage resources, and the computation resources at each edge node. |
| FILED | Thursday, July 01, 2021 |
| APPL NO | 17/365070 |
| CURRENT CPC | Wireless Communication Networks H04W 4/021 (20130101) H04W 16/10 (20130101) Original (OR) Class H04W 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220016598 | Pang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simon Hoching Pang (Fremont, California); Melinda Lia Wah Jue (Livermore, California) |
| ABSTRACT | A resin includes a functionalized aminopolymer having amine sites for capturing carbon dioxide molecules, where each aminopolymer molecule has at least one functional group amenable to crosslinking, a porogen, and a crosslinking initiator. A product includes an aminopolymer material formed into a self-supporting structure, the aminopolymer material including crosslinked aminopolymers having amine sites for the capture of carbon dioxide molecules. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/368598 |
| CURRENT CPC | Separation B01D 53/62 (20130101) B01D 53/81 (20130101) B01D 53/96 (20130101) B01D 2253/34 (20130101) B01D 2253/202 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/267 (20130101) Original (OR) Class B01J 20/3064 (20130101) B01J 20/3085 (20130101) B01J 20/3425 (20130101) B01J 20/3483 (20130101) B01J 20/3491 (20130101) B01J 20/28033 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/50 (20170801) C01B 2210/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016675 | Kumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sortera Alloys, Inc. (Forth Worth, Texas) |
| ASSIGNEE(S) | Sortera Alloys, Inc. (Forth Worth, Texas) |
| INVENTOR(S) | Nalin Kumar (Fort Worth, Texas); Manuel Gerardo Garcia, JR. (Lexington, Kentucky) |
| ABSTRACT | A material sorting system sorts materials utilizing multiple stages of classification and sorting, including a vision system that implements a machine learning system in order to identify or classify each of the materials, and Laser Induced Breakdown Spectroscopy to perform a subsequent classification and sorting of the remaining materials. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/491415 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016829 | Selter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Thomas Matthew Selter (Blue Springs, Missouri); Jamie Michael Messman (Leawood, Kansas) |
| ABSTRACT | A system and method of additively manufacturing a part including electrically conductive or static dissipating fluorine-containing polymers. The method includes depositing fluorine-containing polymer additive manufacturing material onto a build platform, selectively cross-linking portions of the deposited additive manufacturing material, and curing the selectively cross-linked portions such that the part is at least one of electrically conductive and static dissipating. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/490210 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/20 (20170801) B29C 64/135 (20170801) Original (OR) Class Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2027/12 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016856 | Kiefer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Seth M. Kiefer (Kansas City, Missouri); Phillip C. Davis (Independence, Missouri) |
| ABSTRACT | A caul for debulking a composite part broadly includes opposing first and second surfaces, a plurality of through-holes, and a coating. The first surface may have a curvature complementary to a shape of the composite part. The through-holes pass through the caul from the first surface to the second surface. The coating may be a chemically inert material to ensure the caul does not affect the composite part. The caul is configured to be positioned against the composite part for debulking. The caul may be made out of silicone rubber or any other suitable material and may be reusable. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 16/930438 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/3842 (20130101) B29C 70/54 (20130101) Original (OR) Class B29C 70/342 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2819/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017494 | Bara et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Edward Bara (Tuscaloosa, Alabama); Kathryn Elizabeth O'Harra (Tuscaloosa, Alabama) |
| ABSTRACT | The present disclosure provide synthetic methods for the synthesis of N-substituted vinylidene and alkene compounds in addition to compounds formed from such methods. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/322332 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017670 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chen WANG (Superior, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); Nicholas A. RORRER (Golden, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes where R includes a reactive end group, R1 includes a first bridging group, 1≤x≤100, and 1≤y≤100. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/371421 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 216/36 (20130101) Original (OR) Class C08F 236/14 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/14 (20130101) C08J 2367/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017992 | Stuckman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mengling Stuckman (Bethel Park, Pennsylvania); Christina L. Lopano (Bethel Park, Pennsylvania); Thomas Tarka (Pittsburgh, Pennsylvania) |
| ABSTRACT | The invention provides a method for extracting REEs from ash having the steps of contacting ash with a first acid solution to generate leachate having a pH between approximately 5.0 and approximately 5.5; contacting the ash with a second acid solution to generate leachate having a pH between approximately 2.8 and approximately 3.5; and contacting the ash with a third acid solution to generate leachate having a pH between approximately −0.6 and approximately 0.5. The invention also provides a method for leaching REEs from ash having the steps of: contacting ash with a first amount of acid sufficient to leach Ca and AJ from the ash without leaching REEs; contacting the ash with a second amount of acid sufficient to leach REEs from the ash without leaching Fe and Sc; and contacting ash with a third amount of acid sufficient to leach Fe and Sc from the ash. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/376715 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 7/007 (20130101) C22B 59/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018034 | Jiang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junhua Jiang (ldaho Falls, Idaho); Robert D. Mariani (Idaho Falls, Idaho) |
| ABSTRACT | An electrodeposition system, for additive manufacturing of a three-dimensional structure, includes at least one electrochemical cell. The at least one electrochemical cell includes a receptacle containing an electrolytic bath. At least one nozzle opens from the receptacle toward and proximate a substrate, which is configured as a working electrode of the at least one electrochemical cell. The at least one electrochemical cell also includes a counter electrode disposed in the electrolytic bath. In a method for forming a three-dimensional structure, a metal salt, dissolved in the electrolytic salt, flows through the nozzle to deposit a metal of the metal salt on a surface of the substrate configured as the working electrode. The system may be configured for relative movement between the at least one nozzle and the substrate, enabling additive manufacturing of a three-dimensional structure by electrodeposition. |
| FILED | Tuesday, December 10, 2019 |
| APPL NO | 17/309574 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018603 | MA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiwen MA (Golden, Colorado); Jeffrey Clayton GIFFORD (Denver, Colorado); Patrick Gordon DAVENPORT (Boulder, Colorado); Xingchao WANG (Highlands Ranch, Colorado) |
| ABSTRACT | The present disclosure describes heat exchangers for converting thermal energy stored in solid particles to electricity. Electro-thermal energy storage converts off-peak electricity into heat for thermal energy storage, which may be converted back to electricity, for example during peak-hour power generation. The heat exchanger for converting thermal energy stored in solid particles to electricity enables the conversion of thermal energy into electrical energy for redistribution to the grid. In some embodiments, pressurized fluidized-bed heat exchangers may achieve efficient conversion of thermal energy to electricity by providing direct contact of the solid particles with a gas stream. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/376367 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 1/04 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2220/76 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Come into Direct Contact Without Chemical Interaction F28C 3/16 (20130101) Original (OR) Class Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/0056 (20130101) F28D 2020/0069 (20130101) F28D 2020/0078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220020110 | Woo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryana Lynn Woo (Belen, New Mexico); Gabriel Carlisle Birch (Albuquerque, New Mexico); Jaclynn Javonna Stubbs (Albuquerque, New Mexico); Camron G. Kouhestani (Albuquerque, New Mexico) |
| ABSTRACT | A method and system for temporal frequency analysis for identification of unmanned aircraft systems. The method includes obtaining a sequence of video image frames and providing a pixel from an output frame of the video; generating a fluctuating pixel value vector; examining the fluctuating pixel value vector over a period of time; obtaining the frequency information present in the pixel fluctuations; summing the frequency coefficients for the vectorized pixel values from the fluctuating pixel value vector; obtaining an image representing a two dimensional space based on the summed center frequency coefficients; generating a series of still frames equal to a summation of the center frequency coefficients for pixel variations; and combining the temporal information into spatial locations in a matrix to provide a single image containing the spatial and temporal information present in the sequence of video image frame. |
| FILED | Friday, March 12, 2021 |
| APPL NO | 17/200488 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 3/00 (20130101) G06T 3/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220020203 | PAGLIERONI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David W. PAGLIERONI (Pleasanton, California); Harry E. MARTZ, JR. (Livermore, California) |
| ABSTRACT | An automatic threat recognition system and method is disclosed for scanning the x-ray CT image of an article to identify the objects of interest (OOIs) contained within the article, which are otherwise not always quickly apparent or discernable to an individual. The system uses a computer to receive information from two-dimensional (2D) image slices from a reconstructed computed tomography (CT) scan image and to produce a plurality of voxels for each slice of the 2D image. The computer analyzes the voxels to create a likelihood map (LM) representing likelihoods that voxels making up the CT image are associated with a material of interest (MOI). The computer further analyzes the LM to construct neighborhoods of voxels within the LM, and classifies each voxel neighborhood based on its features, thereby decluttering the LM to facilitate the process of connecting voxels of a like MOI together to form segments. The computer classifies each candidate segment based on its features, thereby identifying those segments that correspond to objects of interest. |
| FILED | Tuesday, July 14, 2020 |
| APPL NO | 16/928653 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) G06K 9/6267 (20130101) Image Data Processing or Generation, in General G06T 7/0002 (20130101) G06T 15/005 (20130101) G06T 15/08 (20130101) Original (OR) Class G06T 2207/10081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220020511 | Yin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GE Aviation Systems LLC (Grand Rapids, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weijun Yin (Niskayuna, New York) |
| ABSTRACT | A method of manufacturing an insulated conductive component having an electrically conductive element is provided. The method includes applying a first layer of a first material comprising a thermally conductive ceramic on a portion of the conductive element, and applying a second layer of a second material comprising a polymeric resin over the first layer. The method includes curing the conductive element to infuse the second material into the first material to define an electrically insulative, thermally conductive coating on the portion of the electrically conductive element. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 16/929571 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/185 (20130101) B05D 3/067 (20130101) B05D 3/068 (20130101) Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 13/02 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 13/003 (20130101) H01B 13/16 (20130101) Original (OR) Class H01B 13/0036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220021239 | MA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Purdue Research Foundation - Office of Technology Commercialization (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiwen MA (Golden, Colorado); Jeffrey Clayton GIFFORD (Denver, Colorado); Patrick Gordon DAVENPORT (Boulder, Colorado); Dening JIA (Lakewood, Colorado); Jason SCHIRCK (West Lafayette, Indiana); Aaron MORRIS (West Lafayette, Indiana) |
| ABSTRACT | The disclosure relates to particle heaters for heating solid particles to store electrical energy as thermal energy. Thermal energy storage directly converts off-peak electricity into heat for thermal energy storage, which may be converted back to electricity, for example during peak-hour power generation. The particle heater is an integral part of an electro-thermal energy storage system, as it enables the conversion of electrical energy into thermal energy. As described herein, particle heater designs are described that provide efficient heating of solid particles in an efficient and compact configuration to achieve high energy density and low cost. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375105 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 20/0056 (20130101) F28D 2020/0004 (20130101) F28D 2020/0069 (20130101) F28D 2020/0078 (20130101) F28D 2020/0082 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 15/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220015342 | DUNHAM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AUBURN UNIVERSITY (Auburn, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rex A. DUNHAM (Auburn, Alabama); Zhenkui QIN (Auburn, Alabama); Guyu QIN (Auburn, Alabama) |
| ABSTRACT | Disclosed are fish with impaired reproductive capacity and methods and compositions for producing the same. The reproductively impaired fish may include catfish, such as Ictalurus punctatus. The disclosed methods may be generally useful for mitigating environmental impact of escaped genetically engineered fish. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498110 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Original (OR) Class A01K 2217/00 (20130101) A01K 2217/075 (20130101) A01K 2227/40 (20130101) A01K 2267/02 (20130101) Peptides C07K 14/461 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/8509 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220015348 | Bizati et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nitto, Inc. (Lakewood, New Jersey); Nitto Denko Corporation (Osaka, Japan); The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kujtim Bizati (Kingsport, Tennessee); Yosuke Asamoto (Lakewood, New Jersey); Junwei J. Zhu (Lincoln, Nebraska); Hironao Otake (Osaka, Japan); LIU JEN-CHIEH (Lakewood, New Jersey) |
| ABSTRACT | An adhesive film for attracting and capturing flying insects and method of use are disclosed. The adhesive film includes an adhesive material, an olfactory attractant, a visual attractant and a tackifier. The method of use includes a barrier style trap or a log roll comprised of an adhesive film for attracting and capturing flying insects wound onto a central cylindrical core. The adhesive film may be unwound and attached to a second mounting apparatus. The log roll may be comprised of a continuous sheet of perforated adhesive film which comprises individual sheets wound, which may be removed from the log roll when the adhesiveness of the outer sheet is exhausted, exposing a fresh sheet. |
| FILED | Saturday, October 26, 2019 |
| APPL NO | 17/311316 |
| CURRENT CPC | Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants A01M 1/02 (20130101) A01M 1/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220015367 | HART-COOPER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); Method Products, PBC (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | WILLIAM M. HART-COOPER (RICHMOND, California); WILLIAM J. ORTS (BURLINGAME, California); KAJ JOHNSON (SAUSALITO, California); LAUREN E. LYNN (GLEN GARDNER, New Jersey); DIANA M. FRANQUIVILLANUEVA (CONCORD, California) |
| ABSTRACT | A self-assembled active agent may be formed by a process including covalently bonding at least a first component molecule and a second component molecule, the two component molecules displaying synergy such that the effective amount of the self-assembled active agent is lower than the sum of the effective amounts of the first component molecule and the second component molecule. The component molecules may be chosen such that the covalent bonding is reversible, for example through a hydrazone bond between an amine and an aldehyde. The active agent may thus have controllable activity such as an antimicrobial agent, a biocide, an antiviral agent, a preservative, an antifouling agent, a disinfectant, or a sensor agent, such as for a particular molecule or for pH. |
| FILED | Wednesday, September 08, 2021 |
| APPL NO | 17/469773 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 31/00 (20130101) A01N 47/44 (20130101) Original (OR) Class A01N 49/00 (20130101) A01N 55/08 (20130101) Acyclic or Carbocyclic Compounds C07C 279/18 (20130101) C07C 281/16 (20130101) C07C 281/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016225 | Miller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lowell A. Miller (Greeley, Colorado); Jack C. Rhyan (Fort Collins, Colorado) |
| ABSTRACT | The immune response of an animal to a target immunogen may be enhanced by use of an adjuvant which includes low concentrations of killed cells of Mycobacterium avium subspecies avium in combination with mineral oil. The adjuvant may be used in vaccine compositions for the immunization of an animal against any target immunogen and is particularly preferred for use with immunocontraceptive vaccines such as GnRH immunocontraceptive vaccines conjugated with a Blue carrier protein. |
| FILED | Monday, July 20, 2020 |
| APPL NO | 16/933157 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0006 (20130101) Original (OR) Class A61K 47/62 (20170801) A61K 2039/54 (20130101) A61K 2039/521 (20130101) A61K 2039/552 (20130101) A61K 2039/55505 (20130101) A61K 2039/55594 (20130101) Peptides C07K 14/59 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017430 | Slater et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | S2G Ventures Fund II, L.P. (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven C. Slater (Manchester, Washington); Mauricio Avila-Segura (Madison, Wisconsin); Margaret F. Phillips (McFarland, Wisconsin); Lisa Leilani Z. Durand (Madison, Wisconsin); Gary F. Zimmer (Madison, Wisconsin) |
| ABSTRACT | Provided herein is technology relating to organic fertilizers and particularly, but not exclusively, to organic and/or biodegradable flocculants, methods of preparing organic fertilizers using an organic and/or biodegradable flocculant, and systems for treating water using an organic and/or biodegradable flocculant to prepare an organic fertilizer. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/472205 |
| CURRENT CPC | Organic Fertilisers Not Covered by Subclasses C05B, C05C, e.g Fertilisers From Waste or Refuse C05F 17/10 (20200101) Original (OR) Class C05F 17/40 (20200101) Mixtures of Fertilisers Covered Individually by Different Subclasses of Class C05; Mixtures of One or More Fertilisers With Materials Not Having a Specific Fertilising Activity, e.g Pesticides, Soil-conditioners, Wetting Agents; Fertilisers Characterised by Their Form C05G 5/12 (20200201) C05G 5/45 (20200201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017914 | WINTERMANTEL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | WILLIAM M. WINTERMANTEL (SALINAS, California); NAVNEET KAUR (SALINAS, California); WAYNE B. HUNTER (PORT SAINT LUCIE, Florida) |
| ABSTRACT | The present disclosure provides compositions and methods utilizing double strand ribonucleic acid (dsRNA) to control insects, including whiteflies. More particularly, the present invention relates to several specific synthetic dsRNAs that induce RNA interference (RNAi) in the target insects and methods of delivering the dsRNAs to them, such as allowing feeding on plants treated with, or transgenically expressing, the dsRNAs. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/385172 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/8286 (20130101) Original (OR) Class C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018836 | Nitin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Nitin Nitin (Davis, California); Mahmoudreza Ovissipour (Davis, California) |
| ABSTRACT | Systems, surrogates, indicators and methods for rapid assessment of sanitation processes are provided. Non-living and non-toxic surrogates applied to a platform or encapsulated in a biological material mounted to a platform are exposed to a sanitation process to be evaluated. Responses to sanitation are measured and quantified using FTIR and chemometrics including principal component analysis (PCA), partial least squares regression (PLSR), loading plots and predictive models. An artificial leaf platform with one or more types of surrogates on one surface and an anchor such as an adhesive film on a second surface is described. Surrogate types include nucleic acid, phage, yeast and algae surrogates. Surrogates may also be attached directly or through a polymer to the platform surface. Surrogates may also be encapsulated or attached to the outside of a biological carrier such as a yeast cell that is free or coupled to the platform. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344202 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/44 (20130101) G01J 3/108 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) G01N 33/56911 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220016702 | Spradling et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Millennitek, LLC (Knoxville, Tennessee) |
| ASSIGNEE(S) | Millennitek, LLC (Knoxville, Tennessee) |
| INVENTOR(S) | Andrew M. Spradling (Knoxville, Tennessee); Lawrence W. Townsend (Knoxville, Tennessee) |
| ABSTRACT | A method of forming tungsten tetraboride, by combining tungsten and boron in a molar ratio of from about 1:6 to about 1:12, respectively, and firing the combined tungsten and boron in the hexagonal boron nitride crucible at a temperature of from about 1600 C to about 2000C, to form tungsten tetraboride. |
| FILED | Wednesday, July 15, 2020 |
| APPL NO | 16/947015 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/12 (20130101) B22F 9/04 (20130101) Original (OR) Class B22F 2009/041 (20130101) B22F 2201/11 (20130101) B22F 2201/20 (20130101) B22F 2202/13 (20130101) B22F 2302/05 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017243 | Barber et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey) |
| INVENTOR(S) | Timothy Barber (Litchfield Park, Arizona); Ken E. Young (Peoria, Arizona); Timothy Hindle (Peoria, Arizona) |
| ABSTRACT | A launch lock system includes a first portion rigidly coupled to the second portion in a first state and the first portion movable in all directions relative to the second portion in a second state. The launch lock system includes a fastener subassembly coupled to the second portion, and the fastener subassembly is movable relative to the second portion from a first position to a second position. The launch lock system includes at least one pivot arm subassembly having a pivot arm movable between a first position and a second position. The pivot arm is coupled to the first portion in the first position. In the first state, the pivot arm is in the first position and cooperates with the fastener subassembly in the first position, and in the second state, the pivot arm is uncoupled from the first portion and the fastener subassembly. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 16/930990 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/64 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017479 | Wohl, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as represented by the Adminstrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. Wohl, JR. (Chesapeake, Virginia); John W. Connell (Yorktown, Virginia); Emilie J. Siochi (Newport News, Virginia); Joseph G. Smith, JR. (Smithfield, Virginia) |
| ABSTRACT | Copoly(imide oxetane) materials are disclosed that can exhibit a low surface energy while possessing the mechanical, thermal, chemical and optical properties associated with polyimides. The copoly(imide oxetane)s are prepared using a minor amount of fluorinated oxetane-derived oligomer with sufficient fluorine-containing segments of the copoly(imide oxetane)s migrate to the exterior surface of the polymeric material to yield low surface energies. Thus the coatings and articles of manufacture made with the copoly(imide oxetane)s of this invention are characterized as having an anisotropic fluorine composition. The low surface energies can be achieved with very low content of fluorinated oxetane-derived oligomer. The copolymers of this invention can enhance the viability of polyimides for many applications and may be acceptable where homopolyimide materials have been unacceptable. |
| FILED | Tuesday, September 28, 2021 |
| APPL NO | 17/487803 |
| CURRENT CPC | Heterocyclic Compounds C07D 305/08 (20130101) Original (OR) Class Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/16 (20130101) C08G 65/18 (20130101) C08G 65/322 (20130101) C08G 65/33389 (20130101) C08G 73/02 (20130101) C08G 73/105 (20130101) C08G 73/1042 (20130101) Compositions of Macromolecular Compounds C08L 67/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 179/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017697 | Ghose et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sayata Ghose (Sammamish, Washington); Marcus Anthony Belcher (Sammamish, Washington); John W. Connell (Yorktown, Virginia) |
| ABSTRACT | Compositions including a polyimide and one or more thermally conductive fillers, and compaction rollers for an automated fiber placement machine incorporating the compositions are provided. The polyimide may be a polymeric reaction product of a dianhydride and one or more diamines. The one or more diamines may include a fluorine-containing alkyl ether diamine. The one or more thermally conductive fillers may include one or more of a carbon-based filler, boron nitride, a metal, or combinations thereof. The compositions may have a thermal conductivity of from about 0.2 to about 50 Watts per meter Kelvin (Wm−1 K−1). |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/377116 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/384 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/105 (20130101) C08G 73/1007 (20130101) Original (OR) Class C08G 73/1078 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/08 (20130101) C08K 3/38 (20130101) C08K 3/041 (20170501) C08K 3/046 (20170501) C08K 9/02 (20130101) C08K 2003/085 (20130101) C08K 2003/385 (20130101) C08K 2003/0806 (20130101) C08K 2003/0812 (20130101) C08K 2003/0862 (20130101) C08K 2201/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018060 | Subramaniam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anand Bala Subramaniam (Merced, California); Joseph Pazzi (Merced, California); Vaishnavi Girish (Merced, California) |
| ABSTRACT | Methods and compositions for rapid and efficient assembly of fibers coated with lamellar vesicles are provided. Cosmetic and therapeutic uses of vesicle-coated fibers are also provided. |
| FILED | Thursday, November 14, 2019 |
| APPL NO | 17/293905 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 9/1273 (20130101) A61K 9/1277 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 13/203 (20130101) D06M 15/647 (20130101) D06M 23/02 (20130101) Original (OR) Class Pulp Compositions; Preparation Thereof Not Covered by Subclasses D21C or D21D; Impregnating or Coating of Paper; Treatment of Finished Paper Not Covered by Class B31 or Subclass D21G; Paper Not Otherwise Provided for D21H 19/82 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018741 | Mathies et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Richard A. Mathies (Walnut Creek, California); Anna Butterworth (Berkeley, California); Matin Golozar (Berkeley, California); Jeremy McCauley (Martinez, California); James Stephen Oliver New (London, United Kingdom) |
| ABSTRACT | In various embodiments a capture surface for capturing high velocity and hypervelocity dust and ice particles is provided. In certain embodiments the capture surface is comprised of a soft metal that is chosen to optimize particle capture efficiency, to minimize thermal degradation of chemicals and biochemical in the particles, and to present the captured particles to an analyzer for chemical and biochemical analysis of the particles and their contents. In various embodiments capture chambers comprising one or more such capture surfaces are provided as well as methods of use thereof. |
| FILED | Monday, December 02, 2019 |
| APPL NO | 17/298502 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 1/00 (20130101) B01L 3/52 (20130101) B01L 3/567 (20130101) B01L 3/502715 (20130101) B01L 2200/16 (20130101) B01L 2300/043 (20130101) B01L 2300/045 (20130101) B01L 2300/088 (20130101) B01L 2300/0883 (20130101) B01L 2400/06 (20130101) B01L 2400/0421 (20130101) B01L 2400/0487 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 47/00 (20130101) Cosmonautics; Vehicles or Equipment Therefor B64G 1/66 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2273 (20130101) Original (OR) Class G01N 1/4055 (20130101) G01N 33/6809 (20130101) G01N 35/1095 (20130101) G01N 2001/2279 (20130101) G01N 2001/4061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220017884 | Pillai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Segaran Pillai (Laurel, Maryland); Linda Weigel (Decatur, Georgia); Bernard Quigley (Atlanta, Georgia); David R. Hodge (Washington, District of Columbia) |
| ABSTRACT | Novel Bacillus lysin proteins have been identified and characterized. Methods to detect the presence or absence of bacteria in a sample, methods for lysing bacteria, and methods for decontaminating or disinfecting areas contaminated with bacteria that utilize these lysin proteins have also been developed. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/491845 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 47/44 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) A61K 38/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2405 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Enzymes C12Y 302/01 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220018738 | Cho |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Inho Cho (Egg Harbor Township, New Jersey) |
| ABSTRACT | In an example, a thermal extraction apparatus includes: a housing having a gas inlet and a gas outlet to receive a gas flow through the housing from the gas inlet to the gas outlet, and a side opening to receive a sample collector, having a sample collector adsorbent containing a vapor sample, into a sample collector location; a pump to generate the gas flow; a heater to heat the sample collector adsorbent of the sample collector to a temperature sufficient to release the vapor sample; a thermal desorption (TD) tube connected with the gas outlet of the housing to receive the gas flow downstream of the sample collector and collect the vapor sample released from the sample collector adsorbent of the sample collector; and a cooling member in heat exchange with the TD tube to cool the TD tube. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/162984 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/44 (20130101) G01N 1/2214 (20130101) Original (OR) Class G01N 1/2247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220019649 | Boyd et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Daniel A. Boyd (Arlington, Virginia); Kelli L. Biegger (McLean, Virginia); Chang Ellison (Arlington, Virginia); Brandon P. Gutierrez (Burke, Virginia); Jason Lim (Alexandria, Virginia); William Washington (North Potomac, Maryland) |
| ABSTRACT | An online host method to verify hosted information associated with a user includes establishing, by the online host serving as a relying party system (RPS), a secure connection between the RPS and a user mobile-identification-credential device (UMD). The RPS sends a mobile identification credential (MIC) user information request to the UMD, via the secure connection, seeking release of MIC user information (official information). The RPS obtains from authorizing party system (APS) verification of the MIC user information received in response to the MIC user information request. The RPS stores the MIC user information as hosted information pertaining to the user. The RPS designates the hosted information as base truth information representing the user. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180421 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/32 (20130101) Original (OR) Class G06F 2221/2133 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00288 (20130101) G06K 9/00906 (20130101) G06K 9/6202 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220016224 | Wyss-Coray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton Wyss-Coray (Palo Alto, California); Joseph M. Castellano (Tuckahoe, New York) |
| ABSTRACT | Methods of treating an adult mammal for an aging-associated condition are provided. Aspects of the methods include enhancing a TIMP activity, e.g., a TIMP2 activity, in the mammal in a manner sufficient to treat the adult mammal for the aging-associated condition. Also provided are compositions for use in practicing methods of the invention. A variety of aging-associated conditions may be treated by practice of the methods, which conditions include cognitive impairments. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/496986 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/55 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220016425 | Urbin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. Urbin (Pittsburgh, Pennsylvania) |
| ABSTRACT | A method of acutely activating the noradrenergic systems in a subject can comprise applying one or more electrical pulses to an ear canal (e.g., the left ear canal) of the subject, wherein the one or more electrical pulses are sufficient to acutely activate the noradrenergic system of the subject. Apparatuses and systems for applying one or more electrical pulses to an ear canal are also disclosed. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/378098 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/0484 (20130101) A61N 1/36036 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220017609 | Hansen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Yale University (New Haven, Connecticut); The Regents of the University of California (Oakland, California); The United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James E. Hansen (Guilford, Connecticut); Peter M. Glazer (Guilford, Connecticut); Richard H. Weisbart (Los Angeles, California); Robert N. Nishimura (Santa Monica, California); Grace Chan (Monterey Park, California) |
| ABSTRACT | Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193933 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/337 (20130101) A61K 31/475 (20130101) A61K 31/513 (20130101) A61K 31/704 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/44 (20130101) C07K 2317/73 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220018914 | Holloway et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Lee Holloway (Boulder, Colorado); John Edward Kitching (Boulder, Colorado); Alexandra Brae Artusio-Glimpse (Boulder, Colorado); Vladimir Anatolyevich Aksyuk (Gaithersburg, Maryland); Matthew Thomas Simons (Lafayette, Colorado); Omar Daniel Lopez (Gaithersburg, Maryland) |
| ABSTRACT | An atomic vapor cell for performing RF measurements includes: a first optical window of transparent nonconducting material free of electrically conductive materials; an intermediate frame of transparent nonconducting material free of electrically conductive materials; a second optical window disposed on the intermediate frame and including transparent nonconducting material free of electrically conductive materials to minimize distortion of radiofrequency fields by the windows and frame; and a cell aperture, wherein the atomic vapor cell is hermetically sealed by bonding between the first optical window and the second optical window to the intermediate frame. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 17/374537 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220020979 | Loveness et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Amprius, Inc. (Fremont, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ghyrn E. Loveness (Mountain View, California); William S. Delhagen (San Francisco, California); Rainer J. Fasching (Mill Valley, California); Song Han (Foster City, California); Zuqin Liu (Sunnyvale, California) |
| ABSTRACT | Provided are examples of electrochemically active electrode materials, electrodes using such materials, and methods of manufacturing such electrodes. Electrochemically active electrode materials may include a high surface area template containing a metal silicide and a layer of high capacity active material deposited over the template. The template may serve as a mechanical support for the active material and/or an electrical conductor between the active material and, for example, a substrate. Due to the high surface area of the template, even a thin layer of the active material can provide sufficient active material loading and corresponding battery capacity. As such, a thickness of the layer may be maintained below the fracture threshold of the active material used and preserve its structural integrity during battery cycling. |
| FILED | Tuesday, May 18, 2021 |
| APPL NO | 17/323575 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/58 (20130101) H01M 4/66 (20130101) H01M 4/75 (20130101) H01M 4/134 (20130101) H01M 4/136 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/0428 (20130101) H01M 4/587 (20130101) H01M 4/661 (20130101) H01M 4/667 (20130101) H01M 4/1395 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49108 (20150115) Y10T 29/49115 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220021441 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yan Zhang (Norman, Oklahoma); Hernan A. Suarez Montalvo (Norman, Oklahoma); Sudantha Perera (Broomfield, Colorado) |
| ABSTRACT | An instrument landing system comprises: a wideband antenna configured to receive signals in a VHF band; and a receiver coupled to the wideband antenna and configured to implement SDR functions to analyze the signals for a flight inspection. A UAS comprises: an instrument landing system comprising: a wideband antenna configured to receive signals in a VHF band; and a receiver coupled to the wideband antenna and configured to implement SDR functions to analyze the signals for a flight inspection. A method comprises: receiving, using a wideband antenna, signals in a VHF band; and implementing, using a receiver coupled to the wideband antenna, SDR functions to analyze the signals for a flight inspection. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380960 |
| CURRENT CPC | Transmission H04B 1/16 (20130101) H04B 7/18506 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20220017385 | YIP et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Ngai Yin YIP (Summit, New Jersey); Chanhee BOO (New York, New York); Kinnari SHAH (New York, New York); Ian BILLINGE (New York, New York); Robert Winton (New York, New York); Eliza DACH (New York, New York) |
| ABSTRACT | Systems and methods of performing temperature swing solvent extraction (TSSE) descaling of produced water and desalination of high-salinity brines, e.g., those having a total dissolved solids (TDS) greater than about 250,000 ppm are capable of producing descaled water products including less than about 5% weight percent TDS. The brine/produced water feedstreams and combined with a solvent having temperature-dependent water solubility at a temperature TL. Water is extracted from the feedstream into the solvent to form a water-in-solvent extract component and a raffinate component, from which a solid phase can be precipitated as more water is portioned in the solvent and basicity increases. Heating of the water-in-solvent extract component reduces the solubility of the water therein, producing a biphasic mixture of dewatered solvent and descaled water that can be separated. Because these systems and methods do not require a phase change of water, these products are achieved with significantly higher energy efficiencies when compared to evaporation-based thermal methods. |
| FILED | Monday, May 18, 2020 |
| APPL NO | 17/346915 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/042 (20130101) C02F 1/265 (20130101) Original (OR) Class C02F 2209/02 (20130101) C02F 2209/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20220016178 | Thomson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. Thomson (Madison, Wisconsin); Srikumar Sengupta (Madison, Wisconsin) |
| ABSTRACT | This disclosure relates generally to new methods of maintaining the expression of hepatic genes in human hepatocytes and method for maintaining the functional hepatic enzyme activity of primary hepatocytes in culture. The disclosure also encompasses new methods of deriving a population of pure hepatocytes without selecting or sorting the cells from the cultured pluripotent cells. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/443786 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/407 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/00 (20130101) C12N 5/067 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Geospatial Intelligence Agency (NGA)
| US 20220020169 | Warnaar |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Applied Research Associates, Inc. (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dirk B. Warnaar (Raleigh, North Carolina) |
| ABSTRACT | Systems and techniques for determining a list of geographic location candidates from an image of an environment are described. Open source data indicative of the earth's surface may be obtained and combined into grids to create region data to gain a representation of the earth's surface within each grid cell. An image of an environment may be obtained from an unknown camera. Image characteristics may be compared to the region data to determine error between the image characteristics and projections of the region data. A list of lowest error geographic location candidates may be determined and provided to the user. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/490578 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/04 (20130101) Image Data Processing or Generation, in General G06T 7/73 (20170101) Original (OR) Class G06T 7/80 (20170101) G06T 2207/30244 (20130101) Pictorial Communication, e.g Television H04N 13/111 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220021459 | Kurczveil et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geza Kurczveil (Santa Barbara, California); Di Liang (Santa Barbara, California); Sudharsanan Srinivasan (Santa Barbara, California); Raymond G. Beausoleil (Seattle, Washington) |
| ABSTRACT | Examples herein relate to optical systems. In particular, implementations herein relate to an optical system including an optical transmitter configured to transmit optical signals. The optical transmitter includes a first optical source and a second optical source coupled to the first optical source and injection seeded by the first optical source. The optical transmitter further includes an output coupler, the second optical source coupled to the optical coupler via an output waveguide and configured to emit light having multiple different wavelengths through the output waveguide. In some implementations, the second optical source is self-injection seeded. |
| FILED | Thursday, July 16, 2020 |
| APPL NO | 16/947056 |
| CURRENT CPC | Transmission H04B 10/506 (20130101) Original (OR) Class H04B 10/5057 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220016406 | So et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ViaCyte, Inc. (San Diego, California) |
| ASSIGNEE(S) | ViaCyte, Inc. (San Diego, California) |
| INVENTOR(S) | Vincent So (San Diego, California); Laura Martinson (San Diego, California); Chad Green (San Diego, California); Michael Scott (San Diego, California); Mario Zamarripa (San Diego, California) |
| ABSTRACT | Disclosed herein are implantable 3-dimensional large capacity device assemblies, specifically, large capacity device assemblies for encapsulating pancreatic progenitor cells for treatment of diabetes. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387855 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/022 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 31/002 (20130101) Original (OR) Class A61M 2202/09 (20130101) A61M 2205/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20220021391 | PASANDI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ghasem PASANDI (Los Angeles, California); Massoud PEDRAM (Beverly Hills, California) |
| ABSTRACT | An SFQ circuit system includes at least one SFQ block having a plurality of SFQ logic gates. Characteristically, at least a portion of the SFQ logic gates are arranged in series. The SFQ circuit system includes a timing system configured to provide a first set of inputs and collect a first set of outputs of the at least one SFQ block at a rate defined by a slow clock frequency while the SFQ logic gates are clocked at a fast clock frequency. Advantageously, the rate is sufficiently slow to allow the first set of inputs to propagate through all levels of the SFQ logic gates to produce the first set of outputs of the at least one SFQ block without colliding with a second set of inputs to the at least one SFQ block. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/221998 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Pulse Technique H03K 19/20 (20130101) H03K 19/096 (20130101) H03K 19/195 (20130101) Original (OR) Class H03K 19/17744 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, January 20, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
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THE PANEL
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FUNDED BY
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Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
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FILED
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APPL NO
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3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
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CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
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