FedInvent™ Patent Applications
Application Details for Thursday, January 27, 2022
This page was updated on Friday, January 28, 2022 at 06:36 AM GMT
Department of Health and Human Services (HHS)
| US 20220022765 | Chon et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ki H. Chon (Mansfield, Connecticut); Dong Han (Tolland, Connecticut); Syed Khairul Bashar (Mansfield Center, Connecticut); Fahimeh Mohagheghian (Storrs, Connecticut) |
| ABSTRACT | The present disclosure relates to techniques for the estimating anomalies within photoplethysmographic signals. The techniques may include use of instruments that include photoplethysmographic and acceleration sensors. Time-frequency spectra may be used to determine the anomalies. Corrupted signals may be detected and corrected through applications of machine learning and feature extraction. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/364684 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/341 (20210101) A61B 5/02416 (20130101) Original (OR) Class A61B 5/4836 (20130101) A61B 5/7264 (20130101) A61B 2562/0219 (20130101) Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220022829 | Oakes et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Terrence R. Oakes (Middleton, Wisconsin); Azam Syed Ahmed (Madison, Wisconsin); Joseph A. Kiel (Newport, Minnesota); Jordan Henry (Oregon, Wisconsin); Andrew Culp (Madison, Wisconsin) |
| ABSTRACT | A shield for the bore of radiology scanners provides a resilient sheet material that can be compressed against the inner surface of the bore by a circumference expander greatly simplifying installation. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 17/378860 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/4423 (20130101) Original (OR) Class A61B 46/10 (20160201) A61B 46/40 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220022836 | Contijoch et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francisco Contijoch (La Jolla, California); Brendan Colvert (La Jolla, California); Elliot McVeigh (La Jolla, California) |
| ABSTRACT | Methods, devices, and systems for computed tomography (CT) imaging technologies that are tailored to specific regions of interest and provide a reduced radiation dose. An imaging system for cardiac CT comprises a beam-shaping filtration and exposure control technologies specifically tailored to imaging of the heart. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375895 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/503 (20130101) A61B 6/542 (20130101) Original (OR) Class A61B 6/4035 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/40 (20180101) X-ray Technique H05G 1/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220022955 | KONOFAGOU et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Elisa E. KONOFAGOU (New York, New York); Vincent SAYSENG (Long Island City, New York); Elaine WAN (Fresh Meadows, New York) |
| ABSTRACT | System and methods for monitoring cardiac ablation procedures are disclosed. The system can comprise an imaging device and an image processor. The imaging device can be configured to acquire successive frames and radio frequency signal data of a heart. The image process, coupled to the imaging device, can be configured to obtain a signal envelope of the radio frequency signal data, generate a strain map based on the signal envelope, apply a strain threshold to the strain map for classification of lesion tissue, and provide an image which visualizes lesion formation during the cardiac ablation procedures in real-time. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493108 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/12 (20130101) A61B 8/0883 (20130101) A61B 18/1492 (20130101) Original (OR) Class A61B 2018/00357 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 40/63 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023049 | Flusberg et al. |
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| FUNDED BY |
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| APPLICANT(S) | Pacific Biosciences of California, Inc. (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Flusberg (Atlanta, Georgia); Stephen Turner (Eugene, Oregon); Jon Sorenson (Alameda, California); Kevin Travers (Menlo Park, California); Cheryl Heiner (La Honda, California) |
| ABSTRACT | Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid. |
| FILED | Wednesday, August 26, 2020 |
| APPL NO | 17/003388 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/32 (20130101) A61F 2/30721 (20130101) Original (OR) Class A61F 2002/30062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023119 | Reinkensmeyer et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Reinkensmeyer (Irvine, California); Daniel Zondervan (Irvine, California); Marti Comellas Andres (Irvine, California) |
| ABSTRACT | In one embodiment, a wheelchair device includes a frame adapted to be removably mounted to a wheelchair, a slide member supported by the frame that is configured to be pushed in a forward direction away from a user of the device with the user's arm, a transmission mechanism including a rotatable reel and a spring associated with the reel that resists rotation of the reel in a first direction and assists rotation of the reel in a second direction, and a cable having first and second ends, the first end of the cable being attached to the slide member and the second end being attached to the rotatable reel. With such a configuration, movement of the slide member in the forward direction causes the rotatable reel to rotate in the first direction and movement of the slide member in a backward direction opposite to the forward direction causes the rotatable reel to rotate in the second direction. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/383113 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 5/045 (20130101) Original (OR) Class A61G 5/125 (20161101) A61G 2203/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023230 | Sharp et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); Southwest Research Institute (San Antonio, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zelton Dave Sharp (San Antonio, Texas); John R. Strong (San Antonio, Texas); Veronica Galvan (San Antonio, Texas); Salvatore Oddo (San Antonio, Texas); Herbert G. Wheeler (Boerne, Texas) |
| ABSTRACT | Disclosed are microcapsules that include an inhibitor of the mammalian target of rapamycin (mTOR) within the microcapsules, and pharmaceutical compositions and kits that include the microcapsules. Also disclosed are methods for treating or preventing an age-related disease, condition, or disorder in a subject that involve administering to a subject a pharmaceutically effective amount of microcapsules that includes an inhibitor of mTOR within the microcapsules. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387129 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1635 (20130101) A61K 9/5026 (20130101) A61K 31/00 (20130101) Original (OR) Class A61K 31/436 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023241 | SLAGA et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, the University of Texas System (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas J. SLAGA (San Antonio, Texas); Jacob JUNCO (San Antonio, Texas); Huiyun LIANG (San Antonio, Texas); Sara REYNA (San Antonio, Texas) |
| ABSTRACT | Certain embodiments are directed to methods and compositions for treating obesity, diabetes, and/or cancer with a combination of ursolic acid and resveratrol. |
| FILED | Saturday, April 17, 2021 |
| APPL NO | 17/233455 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/30 (20160801) A23L 33/105 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/19 (20130101) Original (OR) Class A61K 2300/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023245 | Snyder et al. |
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| APPLICANT(S) | Arizona Board Regents on Behalf of the University of Arizona (Tucson, Arizona) |
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| INVENTOR(S) | Robert Snyder (Tucson, Arizona); Brian McKay (Tucson, Arizona) |
| ABSTRACT | The disclosure provides methods for treating or limiting development age-related macular degeneration, comprising (a) a GPR143 receptor agonist, including but not limited to L-DOPA, L-DOPA analogues, or a pharmaceutically acceptable salt thereof, and (b) melatonin, a melatonin analogue, or a pharmaceutically acceptable salt thereof, and related compositions. |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 17/427370 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/165 (20130101) A61K 31/198 (20130101) Original (OR) Class A61K 31/222 (20130101) A61K 31/343 (20130101) A61K 31/4045 (20130101) A61K 38/05 (20130101) A61K 38/06 (20130101) A61K 47/554 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023255 | Kim et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Paul M. Kim (Baltimore, Maryland); Michael D. Kornberg (Baltimore, Maryland); Peter A. Calabresi (Baltimore, Maryland); Solomon H. Snyder (Baltimore, Maryland) |
| ABSTRACT | The disclosure provides methods for (i) treating multiple sclerosis in patient, (ii) treating a patient having symptoms of multiple sclerosis, (iii) preventing the onset of multiple sclerosis symptoms in patient having multiple sclerosis or predisposed to multiple sclerosis; (iv) promoting or enhancing immunomodulation and remyelination and/or myelin repair in a subject in need thereof; (v) a neuroinflammatory disorder; (vi) Amyotrophic Lateral Sclerosis; or (vii) a demyelinating disease or disorder or a hypomyelinating condition, each method comprising administering a therapeutically effective amount of a bryostatin compound to the patient. |
| FILED | Friday, December 06, 2019 |
| APPL NO | 17/311684 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/366 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023291 | Rosen et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Dorian A. Rosen (Charlottesville, Virginia); Alban Gaultier (Charlottesville, Virginia) |
| ABSTRACT | Provided are methods for treating inflammation in subject in need thereof. In some embodiments, the methods include administering to the subject an effective amount of a Sigma-1 receptor (S1R) activity modulator to thereby treat inflammation in the subject. Also provided are pharmaceutical compositions that include an effective amount of a Sigma-1 receptor (S1R) activity modulator and uses of the pharmaceutical compositions to treat inflammation in a subject in need thereof. |
| FILED | Thursday, December 05, 2019 |
| APPL NO | 17/311624 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/341 (20130101) A61K 31/438 (20130101) A61K 31/445 (20130101) A61K 31/495 (20130101) A61K 31/4748 (20130101) Original (OR) Class A61K 31/5375 (20130101) A61K 31/7088 (20130101) A61K 38/54 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023312 | Gallitano-Mendel |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
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| INVENTOR(S) | Amelia L. Gallitano-Mendel (Phoenix, Arizona) |
| ABSTRACT | Methods for detecting psychotic disorders such as but not limited to schizophrenia or bipolar I disorder featuring administering to a patient a dose of an antipsychotic medication; and subjecting the patient to an evaluation at a time point following administration of the dose of the antipsychotic medication. The evaluation is adapted to determine responsiveness or sleepiness (or amount of sleep) resulting from the dose of the antipsychotic medication. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497517 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/4515 (20130101) A61K 31/5415 (20130101) A61K 31/5513 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023328 | Desimone et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Joseph Desimone (Glen Ellyn, Illinois); Yogen Saunthararajah (Cleveland, Ohio) |
| ABSTRACT | Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly. |
| FILED | Wednesday, July 14, 2021 |
| APPL NO | 17/375585 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7068 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023341 | Glimcher et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laurie H. Glimcher (Boston, Massachusetts); Han Dong (Boston, Massachusetts) |
| ABSTRACT | The present invention is based, in part, on the identification of an IRE1α-XBP1-cMyc axis in NK cell immunity. The present invention provides compositions and methods for treating conditions that would benefit from modulating (e.g., upregulating or downregulating) an immune response using an agent that modulates the IRE1α-XBP1 pathway, or a composition comprising modified NK cells. |
| FILED | Monday, November 11, 2019 |
| APPL NO | 17/294477 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023347 | Mitsialis et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | S. Alexander Mitsialis (Newton, Massachusetts); Stella Kourembanas (Newton, Massachusetts) |
| ABSTRACT | Provided herein are isolated exosomes from mesenchymal stem cells (MSC). Such isolated exosomes are substantially CT free of contaminants and are therapeutically active in treating various diseases (e.g., lung diseases such as BPD). The isolated MSC exosomes are identified by one or more protein markers described herein. Methods of purifying such MSC exosomes are also provided. |
| FILED | Wednesday, August 15, 2018 |
| APPL NO | 16/639474 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 33/00 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0662 (20130101) C12N 2502/1352 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023354 | Fischbach et al. |
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| FUNDED BY |
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| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California); The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. Fischbach (Redwood City, California); Ariel R. Brumbaugh (Redwood City, California); Alice G. Cheng (Redwood City, California); Dylan Dodd (Redwood City, California); Justin L. Sonnenburg (Redwood City, California); Kerwyn C. Huang (Redwood City, California); Andres Jesus Aranda-Diaz (Redwood City, California); Steve Higginbottom (Redwood City, California); Min Wang (Redwood City, California); Feiqiao Brian Yu (San Francisco, California) |
| ABSTRACT | The present invention provides high-complexity defined gut microbial communities capable of achieving substantial engraftment and having stability following human fecal community microbial challenge and methods of producing the same. Also provided are methods of using high-complexity defined gut microbial communities for the treatment of dysbiosis or a pathological condition in an animal. |
| FILED | Thursday, November 21, 2019 |
| APPL NO | 17/296012 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023381 | SHOSHAN-BARMATZ et al. |
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| FUNDED BY |
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| APPLICANT(S) | NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD. (Beer-Sheva, Israel); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH and HUMAN SERVICES (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Varda SHOSHAN-BARMATZ (Omer, Israel); Jay CHANG (Bethesda, Maryland); Jeonghan KIM (Andong-si, Gyeongsangbuk-do, South Korea) |
| ABSTRACT | The present invention relates to a method for treating diseases associated with type-1 interferon signaling. Particularly, the present invention is directed to use of specific inhibitors of Voltage-Dependent Anion Channel (VDAC1), such as piperazine- and/or piperidine-derivatives, among others, e.g., peptides and oligonucleotides, for treating an autoimmune disease. |
| FILED | Tuesday, November 26, 2019 |
| APPL NO | 17/297017 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/438 (20130101) A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/4468 (20130101) A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023384 | Pu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | William T. Pu (Chestnut Hill, Massachusetts); Fujian Lu (Brookline, Massachusetts); Vassilios Bezzerides (Brookline, Massachusetts) |
| ABSTRACT | Provided herein are compositions and methods for treating a disorder associated with abnormal RYR2 function (e.g., arrhythmia or heart failure). In some embodiments, method comprises administering to a subject in need thereof an effective amount of a polypeptide comprising a C-terminal domain of Cardiac Myosin binding protein C (MYBPC3) or a nucleic acid or an rAAV encoding such polypeptide. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/371017 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1719 (20130101) Original (OR) Class A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023395 | Bishai et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. Bishai (Baltimore, Maryland); John R. Murphy (Tilghman, Maryland); Drew M. Pardoll (Brookeville, Maryland); Laurene Chung (Baltimore, Maryland); Juan Fu (Lutherville, Maryland); Pankaj Kumar (New Delhi, India); Amit Kumar (Baltimore, Maryland); Sadiya Parveen (Baltimore, Maryland); Cynthia Korin Bullen (Baltimore, Maryland); Vijayan Sambasivam (Puducherry, India); Sumit Siddharth (Baltimore, Maryland); Dipali Sharma (Baltimore, Maryland) |
| ABSTRACT | The present invention is related to a method of treating or preventing cancer in a subject comprising administering to a subject having cancer or prone of getting cancer a first agent that depletes the subject's regulatory T cells (Tregs); followed by administering to the subject a second agent comprising a checkpoint inhibitor. |
| FILED | Wednesday, March 06, 2019 |
| APPL NO | 16/978949 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) Original (OR) Class A61K 38/2013 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) Enzymes C12Y 204/02036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023402 | Nussenblatt et al. |
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| FUNDED BY |
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| APPLICANT(S) | Enzo Biochem, Inc. (New York, New York) |
| ASSIGNEE(S) | Enzo Biochem, Inc. (New York, New York) |
| INVENTOR(S) | Robert Nussenblatt (Bethesda, Maryland); Baoying Liu (North Potomac, Maryland); Lai Wei (Rockville, Maryland); Elazar Rabbani (New York, New York); James J. Donegan (Amesbury, Massachusetts) |
| ABSTRACT | The invention provides immunomodulatory pharmaceutical compositions that include a synthetic peptide and one or more immune tolerance enhancers. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/498834 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0008 (20130101) Original (OR) Class A61K 2039/577 (20130101) A61K 2039/55583 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023410 | Bergeron et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia); THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia); THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Eric Bergeron (Atlanta, Georgia); Scott D. Pegan (Watkinsville, Georgia); Stephen R. Welch (Atlanta, Georgia); Florine E.M. Scholte (Atlanta, Georgia); Christina F. Spiropoulou (Atlanta, Georgia); Stuart T. Nichol (Atlanta, Georgia); Jessica R. Spengler (Atlanta, Georgia) |
| ABSTRACT | Crimean-Congo hemorrhagic fever (CCHF) virus replicon particles (VRP) are described. These VRP are capable of undergoing a single round of virus replication, but are unable to produce new particles or spread to neighboring cells due to the lack of the glycoprotein-encoding M genome segment. In some instances, the VRP contain one or more mutations in the viral ovarian tumor domain protease encoded by the L genome segment or heterologous antigens within its S genome segment. The VRP are shown to elicit a protective immune response against lethal CCHF virus challenge in an animal model. |
| FILED | Friday, December 13, 2019 |
| APPL NO | 17/413304 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023413 | Rubin et al. |
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| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Silver Spring, Maryland) |
| INVENTOR(S) | Steven A. Rubin (Buckeystown, Maryland); Trent J. Bosma (Silver Spring, Maryland); Christian J. Sauder (Rockville, Maryland); Tahir H. Malik (Silver Spring, Maryland) |
| ABSTRACT | A recombinant, attenuated mumps virus is described. The recombinant virus is based on the genotype A Jeryl Lynn vaccine strain, but is modified to express genotype G consensus fusion (F) and hemagglutinin-neuraminidase (HN) proteins. The recombinant virus optionally includes a mutation that prevents expression of viral protein V. The recombinant mumps virus can be used as a vaccine to inhibit mumps virus infection and the development of mumps disease. |
| FILED | Thursday, December 12, 2019 |
| APPL NO | 17/413331 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/165 (20130101) Original (OR) Class A61K 2039/522 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2760/18721 (20130101) C12N 2760/18734 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023417 | O'Reilly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Richard J. O'Reilly (Roxbury, Connecticut); Ekaterina Doubrovina (Bronx, New York); Guenther Koehne (New York, New York); Aisha N. Hasan (Blue Bell, Pennsylvania); Susan E. Prockop (New York, New York) |
| ABSTRACT | Disclosed herein are methods of selecting an allogeneic T cell line for therapeutic administration to a patient having or suspected of having a pathogen or cancer. Also disclosed are methods of selecting a donor from whom to derive an allogeneic T cell line for therapeutic administration to a patient having or suspected of having a pathogen or cancer. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497439 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0011 (20130101) A61K 39/25 (20130101) Original (OR) Class A61K 39/001153 (20180801) A61K 2039/572 (20130101) A61K 2039/5158 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) C12Q 2600/136 (20130101) C12Q 2600/172 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/574 (20130101) G01N 33/57407 (20130101) G01N 2333/03 (20130101) G01N 2333/05 (20130101) G01N 2333/045 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 35/00 (20190201) G16B 35/20 (20190201) G16B 45/00 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/60 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023427 | Manoharan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARBUTUS BIOPHARMA CORPORATION (Burnaby, Canada) |
| ASSIGNEE(S) | ARBUTUS BIOPHARMA CORPORATION (Burnaby, Canada) |
| INVENTOR(S) | Muthiah Manoharan (Cambridge, Massachusetts); Muthusamy Jayaraman (Cambridge, Massachusetts); Kallanthottathil G. Rajeev (Cambridge, Massachusetts); Laxman Eltepu (Cambridge, Massachusetts); Steven Ansell (Cambridge, Massachusetts); Jianxin Chen (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention formula (I) provides lipids having the following structure XXXIII wherein: R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; and E is C(O)O or OC(O). |
| FILED | Thursday, June 24, 2021 |
| APPL NO | 17/357122 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 31/713 (20130101) A61K 31/7088 (20130101) A61K 39/00 (20130101) A61K 39/39 (20130101) A61K 47/10 (20130101) A61K 47/18 (20130101) A61K 47/20 (20130101) A61K 47/28 (20130101) A61K 47/44 (20130101) Original (OR) Class A61K 2039/55555 (20130101) A61K 2039/55561 (20130101) Acyclic or Carbocyclic Compounds C07C 229/08 (20130101) C07C 229/30 (20130101) C07C 237/16 (20130101) C07C 251/38 (20130101) C07C 251/78 (20130101) C07C 271/12 (20130101) C07C 271/20 (20130101) C07C 323/25 (20130101) Heterocyclic Compounds C07D 203/10 (20130101) C07D 317/28 (20130101) C07D 317/44 (20130101) C07D 317/46 (20130101) C07D 317/72 (20130101) C07D 319/06 (20130101) C07D 405/12 (20130101) C07D 491/056 (20130101) C07D 491/113 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/3515 (20130101) C12N 2320/32 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023428 | Spiegel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); Ryan Murelli (Belleville, New Jersey); Andrew Zhang (Waltham, Massachusetts) |
| ABSTRACT | The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule. |
| FILED | Monday, May 17, 2021 |
| APPL NO | 17/322124 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/545 (20170801) A61K 47/549 (20170801) Original (OR) Class A61K 47/6803 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023434 | Bertozzi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carolyn Bertozzi (Menlo Park, California); Steven Banik (Stanford, California); Kayvon Pedram (Stanford, California); Green Ahn (Stanford, California) |
| ABSTRACT | Provided are bifunctional molecules that include a first moiety that specifically binds a cell surface molecule or extracellular molecule, and a second moiety that specifically binds a lysosomal targeting molecule. The bifunctional molecules find use, e.g., for targeted degradation of cell surface and extracellular molecules (e.g., proteins) via the endosomal/lysosomal pathway. Also provided are compositions and kits that include the bifunctional molecules, as well as methods of using the bifunctional molecules. Methods of making bifunctional molecules are also provided. |
| FILED | Wednesday, December 18, 2019 |
| APPL NO | 17/311779 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6425 (20170801) Original (OR) Class A61K 47/6849 (20170801) A61K 47/6855 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023444 | Roy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Subhojit Roy (Madison, Wisconsin); Jichao Sun (Madison, Wisconsin) |
| ABSTRACT | Described herein are CRISPR/Cas9 constructs designed for the C-terminal truncation of human amyloid precursor protein (APP) as well as methods of making and using such a construct. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494457 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 48/0008 (20130101) A61K 48/0058 (20130101) A61K 48/0066 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/4711 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2740/16043 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023445 | Tanifum et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Children's Hospital (Houston, Texas) |
| ASSIGNEE(S) | Texas Children's Hospital (Houston, Texas) |
| INVENTOR(S) | Eric A. Tanifum (Richmond, None); Ketankumar B. Ghaghada (Sugar Land, None); Ananth V. Annapragada (Manvel, None) |
| ABSTRACT | A liposomal composition (“ADx-001”) is provided, ADx-001 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be conjugated to a fourth phospholipid. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403058 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/24 (20130101) A61K 49/108 (20130101) A61K 49/1812 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023450 | Pillarsetty et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Naga Vara Kishore Pillarsetty (Jackson Heights, New York); Steven M. Larson (New York, New York); Sang-gyu Lee (New York, New York) |
| ABSTRACT | Described herein are compositions comprising liposome-based nanocarriers and associated drugs that selectively target bone marrow, minimize tumor delivery, and maintain high drug concentrations in bone marrow when compared to conventional systemic delivery. The compositions also selectively target lymph nodes and other reticuloendothelial system organs (e.g., spleen, e.g., liver), while minimizing delivery to the tumor in order to deliver drugs that prevent bone marrow suppression (BMS) or aid recovery post exposure to radiation. There are a wide range of scenarios for which such radiation protection is useful, e.g., protection from radiation delivered as part of cancer therapy, radiation from weapons, radiation from materials at a nuclear power plant or nuclear waste site, natural radiation in outer space (e.g., for astronauts), and the like. The described compositions are stable for prolonged periods of time, in some cases over a year in a kit formulation. |
| FILED | Tuesday, September 10, 2019 |
| APPL NO | 17/274952 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 31/355 (20130101) A61K 47/24 (20130101) A61K 51/0482 (20130101) A61K 51/1234 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023484 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Yang (State College, Pennsylvania); Kytai T. Nguyen (Grand Prairie, Texas); Zhiwei Xie (State College, Pennsylvania) |
| ABSTRACT | In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499221 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/26 (20130101) A61L 15/44 (20130101) A61L 15/64 (20130101) A61L 15/225 (20130101) Original (OR) Class A61L 15/425 (20130101) A61L 2300/252 (20130101) A61L 2300/404 (20130101) A61L 2300/414 (20130101) A61L 2300/604 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023496 | XIE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingwei XIE (Omaha, Nebraska); Shixuan CHEN (Omaha, Nebraska) |
| ABSTRACT | Nanofiber structures are provided as well as methods of use thereof and methods of making. |
| FILED | Monday, December 16, 2019 |
| APPL NO | 17/413147 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/18 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0656 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023602 | Langer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Robert S. Langer (Newton, Massachusetts); Carlo Giovanni Traverso (Newton, Massachusetts); Sahab Babaee (Arlington, Massachusetts); Simo Pajovic (Mississauga, Canada); Ester Caffarel Salvador (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods related to reconfigurable medical devices are described. In some embodiments, a reconfigurable medical device may include a central core and a plurality of arms. The arms may be rotatably coupled to the central core such that the plurality of arms may rotate outwards away from the central core to selectively reconfigure the reconfigurable device between a retracted configuration and an expanded configuration. In an initial state, the arms may be biased outwards away from the central core into the expanded configuration. When the reconfigurable device is exposed to a temperature greater than a threshold temperature, the arms may be biased towards the central core into the retracted configuration. In some embodiments, a reconfigurable medical device may include therapeutic compound-loaded needles coupled to distal portions of the arms. |
| FILED | Friday, November 15, 2019 |
| APPL NO | 17/293804 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 31/002 (20130101) Original (OR) Class A61M 2205/0266 (20130101) A61M 2210/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023662 | Flynn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (lowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan T. Flynn (lowa City, Iowa); Yusung Kim (lowa City, Iowa); Xiaodong Wu (Coralville, Iowa); Karolyn M. Hopfensperger (lowa City, Iowa); Quentin E. Adams (lowa City, Iowa) |
| ABSTRACT | Methods and systems are described for a rotating shield brachytherapy device. As disclosed herein, the rotating shield brachytherapy (RSBT) apparatus may comprise a radiation source, a drive assembly, a catheter, and an applicator. The applicator can have an outer surface and opposed proximal and distal end portions and a longitudinal axis extending along a length of the catheter. The distal end portion of the catheter can comprise one or more radiation shields and is configured to receive the radiation source. The drive assembly can be configured to engage the proximal end portion of the catheter to selectively rotate the catheter about the longitudinal axis. |
| FILED | Wednesday, September 25, 2019 |
| APPL NO | 17/277506 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1002 (20130101) Original (OR) Class A61N 2005/1005 (20130101) A61N 2005/1094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023667 | Sheng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Radiabeam Systems, LLC (Santa Monica, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ke Sheng (Los Angeles, California); Salime M. Boucher (Santa Monica, California) |
| ABSTRACT | A radiotherapy system and method for delivering radiotherapy are provided. In some aspects, the radiotherapy system includes beam director comprising a radiation source configured to generate radiation for irradiating a patient, the beam director having at least four degrees of freedom of movement. The radiotherapy system also includes a controller configured to operate the beam director to irradiate the patient in accordance with a radiation treatment plan, wherein the radiation treatment plan is generated based on a solution space determined by the at least four degrees of freedom of movement of the beam director. |
| FILED | Monday, June 07, 2021 |
| APPL NO | 17/341076 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1031 (20130101) A61N 5/1083 (20130101) Original (OR) Class A61N 2005/0626 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023859 | Hung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Combinati Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ju-Sung Hung (Palo Alto, California); Andrew Zayac (San Leandro, California); Megan Dueck (Brisbane, California) |
| ABSTRACT | In some aspects, the present disclose provides methods for amplifying and quantifying nucleic acids. Methods for amplifying and quantifying nucleic acids comprise isolating a sample comprising nucleic acid molecules into a plurality of microchambers, performing a polymerase chain reaction on the plurality of microchambers, and analyzing the results of the polymerase chain reaction. In some aspects, the present disclosure provides devices consistent with the methods herein. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175021 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 7/52 (20130101) B01L 2200/0605 (20130101) B01L 2300/18 (20130101) B01L 2300/0609 (20130101) B01L 2300/0851 (20130101) B01L 2300/0864 (20130101) B01L 2400/049 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024869 | Mishra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas); University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanket Jaiprakash Mishra (Mishawaka, Indiana); Brian S.J. Blagg (Niles, Michigan); Chad Anthony Dickey (Tampa, Florida) |
| ABSTRACT | The present technology provides compounds according to Formula I or Formula III as well as compositions including such compounds useful for the treatment of metastatic cancer and/or glaucoma. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226359 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/06 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 207/325 (20130101) Original (OR) Class C07D 401/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024876 | Deiters et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); Albert Einstein College of Medicine (Bronx, New York) |
| INVENTOR(S) | Alexander Deiters (Pittsburgh, Pennsylvania); Kristie E. Darrah (Pittsburgh, Pennsylvania); Mary Frances Cacace (Pittsburgh, Pennsylvania); Ian Cook (Bronx, New York); Thomas Leyh (Bronx, New York); Ting Wang (Bronx, New York) |
| ABSTRACT | Provided herein are small molecule compounds and methods inhibiting human sulfotransferase 1A3 (SULT1A3) using these small molecule compounds. Methods of manufacturing and treatment are also disclosed. |
| FILED | Tuesday, December 10, 2019 |
| APPL NO | 17/299733 |
| CURRENT CPC | Heterocyclic Compounds C07D 215/04 (20130101) C07D 215/48 (20130101) C07D 219/06 (20130101) Original (OR) Class C07D 249/06 (20130101) C07D 401/04 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024877 | Bossmann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas); The UAB Research Foundation (Birmingham, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stefan H. Bossmann (Manhattan, Kansas); Madumali Kalubowilage (Manhattan, Kansas); Man Zhang (Cohoes, New York); Anjana Delpe-Acharige (Manhattan, Kansas); Kayla Eschliman (Manhattan, Kansas); Frank Wolschendorf (Birmingham, Alabama); Olaf Kutsch (Birmingham, Alabama); Alex Dalecki (Birmingham, Alabama); Whitney Narmore (Birmingham, Alabama) |
| ABSTRACT | Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using same. |
| FILED | Friday, September 20, 2019 |
| APPL NO | 17/277631 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 231/22 (20130101) C07D 231/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024884 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Health Research, Inc. (Menands, New York); Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongmin LI (Tucson, Arizona); Zhong LI (Tucson, Arizona); Jia ZHOU (League City, Texas); Jimin XU (Galveston, Texas); Qing-Yu ZHANG (Tucson, Arizona) |
| ABSTRACT | The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of inhibiting viral replication including contacting one or more cells that have been infected with a virus with an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the virus comprises a flavivirus. Also disclosed is a method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection including administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/384051 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Acyclic or Carbocyclic Compounds C07C 233/75 (20130101) Heterocyclic Compounds C07D 211/46 (20130101) C07D 213/75 (20130101) C07D 265/30 (20130101) Original (OR) Class C07D 333/54 (20130101) C07D 409/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024904 | Zeglis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Research Foundation of the City University of New York (New York, New York); University of Saskatchewan (Saskatoon, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Zeglis (New York, New York); Guillaume Dewaele-Le Roi (New York, New York); Eric W. Price (Saskatoon, Canada); Elaheh Khozeimeh Sarbisheh (Saskatoon, Canada) |
| ABSTRACT | A label that permits rebridging of disulfide linkages in antibodies or proteins. The label has a general formula given by wherein R1 is methyl, ethyl or propyl and R2 is a metal chelator, a fluorophore or a click-chemistry synthon. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/368272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/547 (20170801) A61K 47/6851 (20170801) A61K 47/6889 (20170801) A61K 49/0043 (20130101) A61K 49/0058 (20130101) A61K 51/0482 (20130101) A61K 51/1045 (20130101) A61K 51/1093 (20130101) Heterocyclic Compounds C07D 413/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024912 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ONCTERNAL THERAPEUTICS, INC. (San Diego, California); UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| ASSIGNEE(S) | ONCTERNAL THERAPEUTICS, INC. (San Diego, California); UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| INVENTOR(S) | Wei LI (Germantown, Tennessee); Min XIAO (Memphis, Tennessee); James DALTON (Ann Arbor, Michigan); Sunjoo AHN (Daejeon, South Korea); Duane D. MILLER (Collierville, Tennessee); Jin WANG (Memphis, Tennessee) |
| ABSTRACT | The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370201 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 49/786 (20130101) Heterocyclic Compounds C07D 211/14 (20130101) C07D 213/76 (20130101) C07D 217/04 (20130101) C07D 233/64 (20130101) C07D 277/24 (20130101) C07D 405/06 (20130101) C07D 417/04 (20130101) C07D 417/12 (20130101) C07D 417/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024926 | Jacobson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Kenneth A. Jacobson (Silver Spring, Maryland); Dilip K. Tosh (Rockville, Maryland); Marc L. Reitman (Potomac, Maryland); Oksana Gavrilova (Bethesda, Maryland) |
| ABSTRACT | Disclosed are compounds of the formulas (I), (II), and (II): which are A1 adenosine receptor agonists, pharmaceutical compositions comprising such compounds, and a method of use of these compounds, wherein Y, R1-R6, R10-R15, and R20-R22 are as defined in the specification. These compounds are selective to the A1 adenosine receptor, and are contemplated for use in the treatment or prevention of a number of diseases or conditions, for example, for inducing and/or maintaining a hypothermic and/or hypometabolic state for treatment of a mammal. |
| FILED | Friday, December 06, 2019 |
| APPL NO | 17/299890 |
| CURRENT CPC | Heterocyclic Compounds C07D 249/10 (20130101) C07D 471/04 (20130101) C07D 473/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024929 | Gray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); Yanke Liang (Belmont, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Nicholas Paul Kwiatkowski (Brookline, Massachusetts) |
| ABSTRACT | The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject. |
| FILED | Monday, September 28, 2020 |
| APPL NO | 17/034822 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/4162 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class C07D 487/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024949 | Baran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Phil Baran (San Diego, California); Chao Li (San Diego, California); Jie Wang (San Diego, California); Amab K. Chatterjee (San Diego, California); Manoj Kumar (San Diego, California); Shan Yu (San Diego, California); Kristen Johnson (Santee, California); Tian Qin (San Diego, California); Ming Shang (San Diego, California) |
| ABSTRACT | The invention is directed to methods of converting a carboxylic acid group in a compound, via a redox active ester, to a corresponding boronic ester by treatment with bis(pinacolato)diboron-alkyllithium complex in the presence of a ligand, a Ni(II) salt or a copper salt, and an Mg(II) salt, in the presence of an alkyllithium or a lithium hydroxide or alkoxide salt. The product pinacolato boronate ester can be cleaved to provide a boronic acid. The invention is also directed to methods of preparing various compounds of medical value comprising boronic acid groups, and to novel boronic-acid containing compounds of medicinal value, including an atorvastatin boronic acid analog, a vancomycin aglycone boronic acid analog, and boronic acid containing elastase inhibitors mCBK319, mCBK320, mCBK323, and RPX-7009. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/449509 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/0212 (20130101) B01J 2231/344 (20130101) B01J 2531/16 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 47/00 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/027 (20130101) Original (OR) Class Peptides C07K 7/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024978 | Hruby et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| INVENTOR(S) | Victor J. Hruby (Tucson, Arizona); Aswini K. Giri (Tucson, Arizona) |
| ABSTRACT | The present invention relates generally to a compound having both agonist activity at opioid receptor(s) and antagonist activity at NK1 receptor, and methods for producing and using the same. This combination of activities provides several synergistic and/or beneficial effects such as enhanced potency in analgesic effect and reduction or inhibition of tolerance. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499464 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024987 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland); Institute for Research in Biomedicine (Bellinzona, Switzerland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human (Bethesda, Maryland); Institute for Research in Biomedicine (Bellinzona, Switzerland) |
| INVENTOR(S) | Baoshan Zhang (Bethesda, Maryland); Guillaume Stewart-Jones (Bethesda, Maryland); John Mascola (Rockville, Maryland); Kai Xu (Bethesda, Maryland); Gwo-Yu Chuang (Rockville, Maryland); Li Ou (Bethesda, Maryland); Peter Kwong (Washington, District of Columbia); Yaroslav Tsybovsky (Jefferson, Maryland); Wing-Pui Kong (Germantown, Maryland); Aliaksandr Druz (Germantown, Maryland); Davide Corti (Bellinzona, Switzerland); Antonio Lanzavecchia (Bellinzona, Switzerland) |
| ABSTRACT | Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/378587 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/155 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2760/18622 (20130101) C12N 2760/18623 (20130101) C12N 2760/18634 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025001 | Sentman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles L. Sentman (Grantham, New Hampshire); Albert Gacerez (Lebanon, New Hampshire) |
| ABSTRACT | Nucleic acid constructs, vectors, and recombinant cells harboring the nucleic acid constructs or vectors are disclosed. The nucleic acid constructs include genes encoding a chimeric antigen receptor (CAR) and/or one or more transcription factors, optionally mutated. The transcription factors include those that mediate proinflammatory cytokine expression, e.g., T-bet, STAT1, or STAT4. Methods are disclosed of co-expression of the CAR and the transcription factor in a human or non-human immune cell, preferably human T cells. Also disclosed are methods for using these cells for immunotherapy, e.g., in treating cancer, infection, autoimmunity, allergy or inflammation diseases by the administration of a prophylactically or therapeutically effective amount of one or more of the nucleic acid constructs, vectors, and/or immune cells, e.g., human CAR-T cells, described herein. |
| FILED | Friday, April 28, 2017 |
| APPL NO | 16/096562 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4702 (20130101) Original (OR) Class C07K 14/7051 (20130101) C07K 14/70521 (20130101) C07K 16/2827 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/10043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025003 | BAKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David BAKER (Seattle, Washington); Daniel CUNNINGHAM-BRYANT (Seattle, Washington); Emily DIETER (Seattle, Washington); Glenna FOIGHT (Seattle, Washington); Per GREISEN (Seattle, Washington); Dustin MALY (Seattle, Washington); Keunwan PARK (Seattle, Washington); Zhizhi WANG (Seattle, Washington); Cindy WEI (Seattle, Washington) |
| ABSTRACT | The present disclosure provides danoprevir/NS3a complex reader (DNCR) and grazoprevir/NS3a complex readers (GNCR) polypeptides, fusion proteins, and combinations and their use. |
| FILED | Tuesday, December 03, 2019 |
| APPL NO | 17/297606 |
| CURRENT CPC | Peptides C07K 14/4703 (20130101) Original (OR) Class C07K 2319/01 (20130101) C07K 2319/70 (20130101) C07K 2319/81 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/506 (20130101) Enzymes C12Y 304/21098 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025004 | He et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chuan He (Chicago, Illinois); Ralph R. Weichselbaum (Chicago, Illinois); Dali Han (Beijing, China PRC); Meng Xu (Beijing, China PRC) |
| ABSTRACT | The present disclosure provides compositions and methods related to cancer immunotherapy. In particular, the present disclosure identifies YTH N6-Methyladenosine RNA Binding Protein 1 (YTHDF1) as a novel therapeutic target for cancer immunotherapy. Embodiments of the present disclosure provide methods of enhancing cancer immunotherapy that involve attenuating YTHDF1 activity in various cells of the immune system (e.g., APCs) to induce a sufficient and lasting antitumor immune response. |
| FILED | Friday, December 20, 2019 |
| APPL NO | 17/311448 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4703 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025017 | WARE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La jolla, California); PFIZER INC. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl F. WARE (Solana Beach, California); John SEDY (San Diego, California); Tigran AIVAZIAN (San Diego, California); Brian MILLER (San Diego, California); Natasha K. CRELLIN (San Carlos, California) |
| ABSTRACT | The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling. The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188912 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/17 (20130101) A61K 38/177 (20130101) A61K 38/1793 (20130101) A61K 45/06 (20130101) Peptides C07K 14/71 (20130101) Original (OR) Class C07K 14/70578 (20130101) C07K 14/70596 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025028 | Hajishengallis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgios Hajishengallis (Philadelphia, Pennsylvania); John D. Lambris (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Georgios Hajishengallis (Philadelphia, Pennsylvania); John D. Lambris (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure describes methods for preventing or treating periodontitis or diseases associated with periodontitis. The present disclosure also describes methods of screening for compounds that can be used to prevent or treat periodontitis or diseases associated with periodontitis. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493158 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/02 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025040 | Blumberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard S. Blumberg (Weston, Massachusetts); Yu-Hwa Huang (Weston, Massachusetts); Amit Gandhi (Billerica, Massachusetts); Monica Bertagnolli (Newton, Massachusetts); Charles Yoon (Brookline, Massachusetts); Robert George Edward Holgate (Royston, United Kingdom); Arron Robert Hearn (Ely, United Kingdom); Susan Dana Jones (Boston, Massachusetts) |
| ABSTRACT | Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer. |
| FILED | Monday, December 09, 2019 |
| APPL NO | 17/311258 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/30 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/41 (20130101) C07K 2317/73 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025041 | Majeti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravindra Majeti (Palo Alto, California); Irving L. Weissman (Stanford, California); Siddhartha Jaiswal (San Francisco, California); Mark P. Chao (Mountain View, California) |
| ABSTRACT | Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/350963 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Peptides C07K 16/28 (20130101) C07K 16/30 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/2896 (20130101) C07K 2317/73 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0093 (20130101) C12N 5/0694 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/57426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025053 | Kreeger et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pamela Kay Kreeger (Middleton, Wisconsin); Molly Jane Carroll (Madison, Wisconsin); Kaitlin C. Fogg (Fitchburg, Wisconsin) |
| ABSTRACT | As described herein, a method of inhibiting metastasis in cancer includes administering to a human subject diagnosed with a cancer of an organ of the peritoneal cavity a therapeutically effective amount of an inhibitor of CCR5 or P-selectin. Preferably the subject has a tumor positive for a ligand of P-selectin such as a CD24+ or PSGL-1+ tumor. Analysis of samples from HGSOC patients confirmed increased MIP-1β and P-selectin, suggesting that this novel multi-cellular mechanism can be targeted to slow or stop metastasis in cancers such as high-grade serous ovarian cancer, for example by using anti-CCR5 and P-selectin therapies developed for other indications. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/495893 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/439 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/24 (20130101) C07K 16/2854 (20130101) Original (OR) Class C07K 16/2866 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025057 | Bertozzi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carolyn Bertozzi (Menlo Park, California); Steven Banik (Stanford, California); Kayvon Pedram (Stanford, California); Green Ahn (Stanford, California) |
| ABSTRACT | Provided are bifunctional molecules that include a first moiety that specifically binds a cell surface molecule or extracellular molecule, and a second moiety that specifically binds a lysosomal targeting molecule. The bifunctional molecules find use, e.g., for targeted degradation of cell surface and extracellular molecules (e.g., proteins) via the endosomal/lysosomal pathway. Also provided are compositions and kits that include the bifunctional molecules, as well as methods of using the bifunctional molecules. Methods of making bifunctional molecules are also provided. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499272 |
| CURRENT CPC | Peptides C07K 16/2827 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 16/2881 (20130101) C07K 2317/55 (20130101) C07K 2317/77 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025111 | Chiu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Daniel T. Chiu (Seattle, Washington); Lei Chen (Seattle, Washington); Jiangbo Yu (Seattle, Washington) |
| ABSTRACT | Polymers, monomers, narrow-band absorbing polymers, narrow-band absorbing monomers, absorbing units, polymer dots, and related methods are provided. Bright, luminescent polymer nanoparticles with narrow-band absorptions are provided. Methods for synthesizing absorbing monomers, methods for synthesizing the polymers, preparation methods for forming the polymer nanoparticles, and applications for using the polymer nanoparticles are also provided. |
| FILED | Monday, September 16, 2019 |
| APPL NO | 17/276690 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/02 (20130101) C08G 61/122 (20130101) Original (OR) Class C08G 79/08 (20130101) C08G 2261/1434 (20130101) C08G 2261/3244 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6486 (20130101) G01N 33/54346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025308 | Rogers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hunter B. Rogers (Chicago, Illinois); Teresa K. Woodruff (Chicago, Illinois) |
| ABSTRACT | Tissue culture platforms that may be configured for tissue culture or biological cell culture, and methods for use thereof, are described. In general, the tissue culture platforms include multiple well chambers that are fluidically coupled by one or more channels Flow between the different well chambers is controlled via one or more selector valves, enabling a single tissue culture platform that can provide multiple integrated culture subsystems, multiple non-interacting culture subsystems, or combinations thereof. |
| FILED | Wednesday, October 16, 2019 |
| APPL NO | 17/309061 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) Original (OR) Class C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/26 (20130101) C12M 23/34 (20130101) C12M 23/48 (20130101) C12M 23/58 (20130101) C12M 27/00 (20130101) C12M 29/00 (20130101) C12M 41/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025312 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Abraham P. Lee (Irvine, California); Xiaolin Wang (Shanghai, China PRC); Duc Phan (Fountain Valley, California); Christopher C.W. Hughes (Irvine, California); Steven C. George (St. Louis, Missouri) |
| ABSTRACT | A pressure regulator module for a chip-based microfluidic platform is provided. The module includes a microfluidic channel for passing flowable material from the inlet region through the outlet region and into a downstream compartment; one or more microvalves fluidly connected to the microfluidic channel and upstream of the outlet region; and one or more reservoirs fluidly connected to the microvalves, for receiving flowable material diverted by the microvalves, where a flow of flowable material passing from the inlet region toward the downstream compartment is at least partially diverted by the microvalves into the reservoirs as a result of a pressure increase in the microfluidic channel. In some versions, the microvalves are capillary burst valves. A microfluidic chip containing the module and a method of using the module are provided. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492263 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502738 (20130101) B01L 3/502761 (20130101) B01L 2200/0647 (20130101) B01L 2300/0864 (20130101) B01L 2400/0688 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) Original (OR) Class C12M 29/10 (20130101) C12M 41/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025331 | Athanasiou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyriacos A. Athanasiou (Irvine, California); Jerry C. Hu (Irvine, California); Wendy E. Brown (Irvine, California) |
| ABSTRACT | Methods and systems for enhancing cell populations such as chondrocytes for tissue engineering applications, e.g., for production of neocartilage. The methods and systems of the present invention feature the introduction of a hypotonic buffer to the cells during the cell isolation process, which results in neotissue (e.g., neocartilage) constructs that are significantly more mechanically robust as compared to those not treated with hypotonic buffer. The methods and systems may further comprise introducing cytochalasin D to cells purified with a hypotonic buffer, which can further bolster the mechanical properties and matrix deposition of the cells. The methods and systems result in neocartilage engineered from chondrocytes, for example, from fetal aged tissue, having compressive properties on par with native adult articular cartilage. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496391 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0655 (20130101) Original (OR) Class C12N 2501/10 (20130101) C12N 2501/30 (20130101) C12N 2501/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025339 | Kawaoka et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (WARF) (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yoshihiro Kawaoka (Middleton, Wisconsin); Satoshi Fukuyama (Kanagawa, Japan); Shinji Watanabe (Tokyo, Japan) |
| ABSTRACT | The disclosure provides for an isolated recombinant influenza virus having at least one of: a PA gene segment encoding PA with a residue at position 443 that is not arginine, a PB1 gene segment encoding PB1 with a residue at position 737 that is not lysine, a PB2 gene segment encoding PB2 with a residue at position 25 that is not valine or a residue at position 712 that is not glutamic acid, a NS gene segment encoding a NS1 with a residue at position 167 that is not proline, a HA gene segment encoding a HA with a residue at position 380 that is not threonine, or any combination thereof, and methods of making and using the virus. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/352845 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025347 | Joung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Benjamin Kleinstiver (Boston, Massachusetts) |
| ABSTRACT | Engineered CRISPR from Prevotella and Francisella 1 (Cpf1) nucleases with altered and improved target specificity and their use in genomic engineering, epigenomic engineering, genome targeting, genome editing, and in vitro diagnostics. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/450593 |
| CURRENT CPC | Peptides C07K 14/39 (20130101) C07K 2319/00 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/0071 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 114/11 (20130101) C12Y 301/21004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025349 | Henrich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ian Henrich (Philadelphia, Pennsylvania); Margaret M. Chou (Bala Cynwyd, Pennsylvania) |
| ABSTRACT | Compositions and methods for treating cancer are provided. In accordance with the instant invention, methods of inhibiting or treating cancer, particularly a “cold” cancer or a cancer lacking CD8+ tumor infiltrating lymphocytes (TILs) and/or other immunostimulatory features, in a subject are provided. In a particular embodiment, the method comprises administering an agent which increases ubiquitin-specific protease 6 (USP6) activity and/or expression to the subject. |
| FILED | Wednesday, November 27, 2019 |
| APPL NO | 17/296722 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/215 (20130101) A61K 38/4813 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) Original (OR) Class Enzymes C12Y 304/19012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025378 | Gomez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher M. Gomez (Chicago, Illinois); Yu Miyazaki (Chicago, Illinois); Xiaofei Du (Chicago, Illinois) |
| ABSTRACT | The invention provides methods of treating polyglutamine diseases, e.g., spinocerebellar ataxia Type 6, in a subject, comprising administering to the subject an IRES inhibitor in an amount effective for treating the SCA6 in the subject. Also provided herein are the IRES inhibitors, and pharmaceutical compositions comprising the same. |
| FILED | Tuesday, June 15, 2021 |
| APPL NO | 17/348090 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2330/50 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025379 | GOLDMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. GOLDMAN (Webster, New York); Zhengshan LIU (Rochester, New York) |
| ABSTRACT | The present disclosure relates to methods of restoring K+ uptake by glial cells in a subject. These methods involve administering, to the subject, a SMAD4 inhibitor under conditions effective to restore K+ uptake by said glial cells. The present disclosure is also directed to methods of treating or inhibiting the onset of a neuropsychiatric disorder in a subject. These methods involve administering, to a subject in need thereof, a SMAD4 inhibitor under conditions effective to treat or inhibit the onset of the neuropsychiatric disorder in the subject. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 17/413384 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/18 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/122 (20130101) C12N 2310/531 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025395 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts) |
| ABSTRACT | Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492512 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025397 | MORIZONO |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (OAKLAND, California) |
| INVENTOR(S) | Kouki MORIZONO (LOS ANGELES, California) |
| ABSTRACT | Described is a targeting construct encoding a modified Sindbis virus envelope protein, comprising mutations in the E1, E2 and/or E3 proteins, fused with a monomeric biotin-binding molecule. Lentiviral vectors pseudotyped with the novel envelope proteins, such as E2 71 eMA and E2 71 mSAH, can be conjugated with biotinylated targeting ligands The conjugated ligands mediate specific binding and transduction of the target cell types. This lentiviral transduction system can be used to selectively deliver transgenes into specific cell types in vivo, which increases the numbers of vectors reaching the targeted cells and tissues and decreases adverse effects in non-targeted cells and tissues. The vectors transduce B cells without conjugation of targeting ligands. The B cell type most efficiently transduced in this manner is long-lived plasma cells, and thus can be used for long-term transgene expression. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 17/250921 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/64 (20170801) A61K 47/6811 (20170801) Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 2319/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2740/15043 (20130101) C12N 2770/36122 (20130101) C12N 2770/36142 (20130101) C12N 2810/855 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025398 | HRVATIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Sinisa HRVATIN (Cambridge, Massachusetts); Mark Aurel NAGY (Cambridge, Massachusetts); Michael E. GREENBERG (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to adeno-associated vims (AAV) vectors comprising at least one gene regulatory element (GRE) and cells comprising said vectors. In another aspect, described herein are methods of screening for said gene regulatory elements. In another aspect, described herein are nucleic acid compositions comprising a GRE as described herein. |
| FILED | Thursday, December 05, 2019 |
| APPL NO | 17/311255 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/1065 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025399 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guangping Gao (Westborough, Massachusetts); James M. Wilson (Philadelphia, Pennsylvania); Mauricio R. Alvira (Philadelphia, Pennsylvania) |
| ABSTRACT | Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492229 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/761 (20130101) A61K 38/45 (20130101) A61K 38/177 (20130101) A61K 38/4846 (20130101) A61K 48/00 (20130101) Peptides C07K 14/005 (20130101) C07K 14/705 (20130101) C07K 14/755 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/644 (20130101) C12N 9/1018 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 15/8645 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2750/14152 (20130101) C12N 2830/008 (20130101) C12N 2830/48 (20130101) C12N 2830/85 (20130101) Enzymes C12Y 201/03003 (20130101) C12Y 304/21021 (20130101) C12Y 304/21022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025407 | Doudna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emmanuelle Charpentier (Berlin, Germany); The Regents of the University of California (Oakland, California); University of Vienna (Vienna, Austria) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Martin Jinek (Berkeley, California); Krzysztof Chylinski (Vienna, Austria); Emmanuelle Charpentier (Berlin, Germany) |
| ABSTRACT | The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/481085 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/4684 (20180501) Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/746 (20130101) C12N 15/902 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/13 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Enzymes C12Y 301/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025408 | DEVER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (STANFORD, California) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (STANFORD, California) |
| INVENTOR(S) | DANIEL P. DEVER (STANFORD, California); RASMUS O. BAK (STANFORD, California); AYAL HENDEL (STANFORD, California); WARACHAREE SRIFA (STANFORD, California); MATTHEW H. PORTEUS (STANFORD, California) |
| ABSTRACT | In certain aspects, the present invention provides methods for inducing a stable gene modification of a target nucleic acid via homologous recombination in a primary cell, such as a primary blood cell and/or a primary mesenchymal cell. In certain other aspects, the present invention provides methods for enriching a population of genetically modified primary cells having targeted integration at a target nucleic acid. The methods of the present invention rely on the introduction of a DNA nuclease such as a Cas polypeptide and a homologous donor adeno-associated viral (AAV) vector into the primary cell to mediate targeted integration of the target nucleic acid. Also provided herein are methods for preventing or treating a disease in a subject in need thereof by administering to the subject any of the genetically modified primary cells or pharmaceutical compositions described herein to prevent the disease or ameliorate one or more symptoms of the disease. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502402 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025409 | Dever et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | Daniel P. Dever (Stanford, California); Rasmus O. Bak (Stanford, California); Ayal Hendel (Stanford, California); Waracharee Srifa (Stanford, California); Matthew H. Porteus (Stanford, California) |
| ABSTRACT | In certain aspects, the present invention provides methods for inducing a stable gene modification of a target nucleic acid via homologous recombination in a primary cell, such as a primary blood cell and/or a primary mesenchymal cell. In certain other aspects, the present invention provides methods for enriching a population of genetically modified primary cells having targeted integration at a target nucleic acid. The methods of the present invention rely on the introduction of a DNA nuclease such as a Cas polypeptide and a homologous donor adeno-associated viral (AAV) vector into the primary cell to mediate targeted integration of the target nucleic acid. Also provided herein are methods for preventing or treating a disease in a subject in need thereof by administering to the subject any of the genetically modified primary cells or pharmaceutical compositions described herein to prevent the disease or ameliorate one or more symptoms of the disease. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502421 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2750/14143 (20130101) C12N 2800/80 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025442 | Zhuang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Xiaowei Zhuang (Cambridge, Massachusetts); Kok-Hao Chen (Cambridge, Massachusetts); Alistair Boettiger (Cambridge, Massachusetts); Jeffrey R. Moffitt (Cambridge, Massachusetts); Siyuan Wang (Cambridge, Massachusetts) |
| ABSTRACT | The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 17/374000 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6811 (20130101) C12Q 1/6816 (20130101) Original (OR) Class C12Q 1/6876 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025444 | Samusik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolay Samusik (Mountain View, California); Garry P. Nolan (Redwood City, California); Yury Goltsev (Stanford, California); David Robert McIlwain (Palo Alto, California) |
| ABSTRACT | A method for analyzing planar sample is provided. In some cases the method comprises: (a) labelling the planar sample with a capture agent that is linked to a nucleic acid, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the nucleic acid, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185757 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6818 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025448 | Levner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Levner (Boston, Massachusetts); Je-Hyuk Lee (Allston, Massachusetts); George M. Church (Brookline, Massachusetts); Michael Super (Lexington, Massachusetts) |
| ABSTRACT | The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/498829 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6816 (20130101) C12Q 1/6837 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025463 | Abudayyeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar Abudayyeh (Cambridge, Massachusetts); James Joseph Collins (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Feng Zhang (Cambridge, Massachusetts); Eric S. Lander (Cambridge, Massachusetts); Aviv Regev (Cambridge, Massachusetts) |
| ABSTRACT | The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect both DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495219 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6804 (20130101) C12Q 1/6827 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025465 | Watson-Hurthig et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Watson-Hurthig (Tucson, Arizona); Ghassan Mouneimne (Tucson, Arizona); Casey Romanoski (Tucson, Arizona); Adam Grant (Tucson, Arizona); Megha Padi (Tucson, Arizona) |
| ABSTRACT | Provided herein are compositions and methods for characterizing and treating cancer. In particular, provided herein are compositions and methods for identifying subjects with breast cancer with increased likelihood of bone metastasis and providing treatment to prevent such metastases. |
| FILED | Thursday, November 14, 2019 |
| APPL NO | 17/293578 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026275 | ASGHAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES (Boca Raton, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Waseem ASGHAR (Boca Raton, Florida); Benjamin COLEMAN (Houston, Texas); Chad COARSEY (Boca Raton, Florida) |
| ABSTRACT | A video processing method improves the repeatability of point-of-care (POC) mean pixel intensity (MPI) analysis, for example by rejecting low-quality input data using image features. Using these features, the method selects high-quality frames and achieves an improvement in correlation and standard error for the MPI-absorbance relationship. In another example, a mobile device (e.g., smartphone) based image processing method produces an MPI output with smaller variances, lower limits of detection (LODs), and a higher dynamic range than existing methods. This method has improved performance in the presence of additive and multiplicative ambient light noise. |
| FILED | Monday, October 21, 2019 |
| APPL NO | 17/311893 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/2823 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/22 (20130101) G06K 9/036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026331 | Simpson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Garth Jason Simpson (West Lafayette, Indiana); Chen Li (West Lafayette, Indiana); Changqin Li (West Lafayette, Indiana) |
| ABSTRACT | A method of obtaining a measurement signal representative of the particle size distributions in nanocrystal suspensions that includes a step of providing a first light beam along a first axis to a first micro-retarder array to generate polarization wavefront shaped light. The shaped light is applied to an objective configured to focus two orthogonally polarized components of the polarization wavefront shaped light to produce first and second axially offset foci along the first axis. A sample having particles in suspension is disposed in one foci to produce a measurement optical signal having phase and intensity values corresponding to at least some of the particles in suspension. The method also includes determining intensity and quantitative phase information as a function of time based on the optical signals. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/329017 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0224 (20130101) G01J 3/457 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0211 (20130101) Original (OR) Class G01N 15/0227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026332 | Hering et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| ASSIGNEE(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| INVENTOR(S) | Susanne Vera Hering (Berkeley, California); Gregory Stephen Lewis (Berkeley, California); Steven Russel Spielman (Oakland, California) |
| ABSTRACT | A method and apparatus to create water vapor supersaturation and particulate counts from an air sample. The method and apparatus include introducing an air sample into a chamber by passing a flow into the chamber through the inlet by pumping at the outlet. The method further includes closing the inlet while continuing the pumping to exhaust the air sample from the chamber through the outlet. The pumping is performed at a rate operable to reduce pressure inside the chamber such that the air sample in the central portion of the chamber cools, and water vapor from walls of the chamber has time to diffuse into the air sample in the chamber from the walls. The cycles are repeated by continuously repeating the introducing and closing. The walls of the chamber may be wet or dry. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/492955 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/065 (20130101) Original (OR) Class G01N 2015/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026333 | Hering et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| ASSIGNEE(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| INVENTOR(S) | Susanne Vera Hering (Berkeley, California); Gregory Stephen Lewis (Berkeley, California); Steven Russel Spielman (Oakland, California) |
| ABSTRACT | A method and apparatus to create water vapor supersaturation and particulate counts from an air sample. The method and apparatus include introducing an air sample into a chamber by passing a flow into the chamber through the inlet by pumping at the outlet. The method further includes closing the inlet while continuing the pumping to exhaust the air sample from the chamber through the outlet. The pumping is performed at a rate operable to reduce pressure inside the chamber such that the air sample in the central portion of the chamber cools, and water vapor from walls of the chamber has time to diffuse into the air sample in the chamber from the walls. The cycles are repeated by continuously repeating the introducing and closing. The walls of the chamber may be wet or dry. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494449 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026412 | Di Carlo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Dino Di Carlo (Los Angeles, California); Peter Tseng (Saratoga, California); Ivan Pushkarsky (San Diego, California) |
| ABSTRACT | A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496752 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) B01L 2300/168 (20130101) B01L 2300/0654 (20130101) B01L 2300/0829 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/247 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 33/487 (20130101) G01N 33/582 (20130101) G01N 33/5026 (20130101) Original (OR) Class G01N 2021/6419 (20130101) G01N 2021/6441 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026429 | Halvorsen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for the State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Anders Halvorsen (Glenmont, New York); Arun Richard Chandrasekaran (Albany, New York) |
| ABSTRACT | The present disclosure is directed to a polynucleotide capable of signaling under preselected conditions. For example, the present disclosure relates to a method of reconfiguring a nucleic acid or polynucleotide, including: contacting a deoxyribonucleic acid (DNA) nanoswitch and nucleic acid to form a DNA nanoswitch-nucleic acid complex having a first conformation, wherein the first conformation is characterized as locked; contacting the DNA nanoswitch-nucleic acid complex with a biological specimen to form a mixture, wherein when the nucleic acid is ribonucleic acid (RNA) and the biological specimen includes one or more ribonucleases, the first conformation changes to a second conformation characterized as open; processing the mixture under conditions sufficient to separate the first conformation, and when present, the second conformation; and reacting the first conformation, and when present, the second conformation with an indicator under conditions sufficient to form a signal. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381836 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/447 (20130101) G01N 33/573 (20130101) Original (OR) Class G01N 2333/922 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026433 | GUO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia GUO (Tempe, Arizona); Manas MONDAL (Tempe, Arizona); Renjie LIAO (Tempe, Arizona); Lu XIAO (Tempe, Arizona) |
| ABSTRACT | Provided herein are methods for multiplexed in situ analysis of biomolecules in a tissue. In particular, provided herein are methods for multiplexed single-cell in situ protein and nucleic acid profiling in fixed or fresh tissues, and also allows the investigation of the different cell compositions and their spatial organizations in intact tissues through consecutive cycles of probe hybridization, fluorescence imaging, and signal removal. |
| FILED | Monday, November 11, 2019 |
| APPL NO | 17/294281 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/64 (20130101) G01N 33/582 (20130101) Original (OR) Class G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220028067 | Alizad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azra Alizad (Rochester, Minnesota); Mahdi Bayad (Cleveland, Ohio); Mostafa Fatemi (Rochester, Minnesota); Seyed Siavash Ghavami Roudsari (Rochester, Minnesota) |
| ABSTRACT | Described here are systems and methods for quantifying vessel features in non-contrast microvasculature images obtained with an ultrasound imaging system. Vessel features that are quantified include, but are not limited to, vessel structure features (e.g., number of vessels, vessel density, number of branch points), vessel diameter, and vessel tortuosity. Morphological filtering is used to generate vessel segments from which the quantitative vessel features can be reliably quantified. |
| FILED | Monday, December 09, 2019 |
| APPL NO | 17/299907 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/483 (20130101) A61B 8/0891 (20130101) A61B 8/4461 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) Original (OR) Class G06T 7/155 (20170101) G06T 2200/24 (20130101) G06T 2207/10136 (20130101) G06T 2207/20036 (20130101) G06T 2207/30101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220028131 | HELM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Medtronic Navigation, Inc. (Louisville, Colorado); Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick A. HELM (Milton, Massachusetts); Jeffrey H. SIEWERDSEN (Baltimore, Maryland); Ali UNERI (Baltimore, Maryland); Wojciech ZBIJEWSKI (Baltimore, Maryland); Xiaoxuan ZHANG (Baltimore, Maryland); Joseph W. STAYMAN, IV (Baltimore, Maryland) |
| ABSTRACT | Selected artifacts, which may be based on distortions or selected attenuation features, may be reduced or removed from a reconstructed image. Various artifacts may occur due to the presence of a metal object in a field of view. The metal object may be identified and removed from a data that is used to generate a reconstruction. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/493208 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/5282 (20130101) A61B 34/10 (20160201) A61B 90/37 (20160201) A61B 2034/102 (20160201) A61B 2090/376 (20160201) A61B 2090/3764 (20160201) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/005 (20130101) G06T 7/60 (20130101) G06T 11/006 (20130101) Original (OR) Class G06T 2207/10124 (20130101) G06T 2207/20081 (20130101) G06T 2207/20182 (20130101) G06T 2207/20221 (20130101) G06T 2207/30052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220028480 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Baker (South Bend, Indiana); Tim Riley (South Bend, Indiana) |
| ABSTRACT | Described are methods for predicting affinity of a candidate molecule for a second molecule. The method comprises obtaining a three-dimensional candidate structural representation of the candidate molecule bound to a second molecule; obtaining a plurality of candidate measurements, wherein each candidate measurement is associated with at least one feature of the candidate structural representation; and predicting, with an electronic processor, the affinity of the candidate molecule for the second molecule, wherein the electronic processor is configured to predict the affinity of the candidate molecule for the second molecule based upon the plurality of candidate measurements. The candidate molecule may be a peptide, such as a neoantigen, a viral peptide, a non-mutated self peptide, or a post-translationally modified peptide. The second molecule may be an antigen presenting molecule, such as a class I MHC molecule or a class II MHC molecule. |
| FILED | Friday, December 06, 2019 |
| APPL NO | 17/312107 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/30 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220028674 | Cooks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Graham Cooks (West Lafayette, Indiana); Zheng Ouyang (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/395909 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/91 (20130101) G01N 30/95 (20130101) G01N 33/49 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0031 (20130101) Original (OR) Class H01J 49/167 (20130101) H01J 49/168 (20130101) H01J 49/0404 (20130101) H01J 49/0409 (20130101) H01J 49/0431 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029567 | Trumper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Trumper (Plaistow, New Hampshire); Benjamin Weinreb (Boston, Massachusetts) |
| ABSTRACT | A motor system can include a bearingless stator having a plurality of magnetic windings including rotation windings and suspension windings; a dipole interior permanent magnet (IPM) rotor positioned within the stator, the rotor having a plurality of permanent magnets disposed within a cylindrical structure; one or more position sensors to measure radial and angular position of the rotor; and a controller configured to receive measurements from the one or more position sensors and to generate current commands for the stator to excite the rotation windings to generate torque and to excite the suspension windings to stabilize the rotor within the stator. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/331712 |
| CURRENT CPC | Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 21/18 (20160201) H02P 21/22 (20160201) Original (OR) Class H02P 2207/05 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029897 | Han et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Han (Bridgewater, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Muhammad Bilal Anwer (Branchburg, New Jersey); Zhi-Li Zhang (Eden Prairie, Minnesota); Yang Zhang (Saint Paul, Minnesota) |
| ABSTRACT | Systems, computer-readable media, and methods are disclosed for parallel data processing for service function chains with network functions spanning multiple servers. An example system includes a first server hosting a first network function of a service function chain, a second server hosting a second network function of the service function chain, a mirror function deployed in a first switch to replicate a plurality of packets received by the system and to send respective copies of the plurality of packets to the first network function and to at least one of the second network function and a third network function of the service function chain, and a merge function deployed in a second switch to merge respective outputs of the first network function and the at least one of the second network function and the third network function. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498440 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/5054 (20130101) Original (OR) Class H04L 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220022801 | Wendelken et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Utah Research Foundation (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suzanne Wendelken (Salt Lake City, Utah); Tyler Davis (Salt Lake City, Utah); David Page (Salt Lake City, Utah); David Kluger (Salt Lake City, Utah); David Warren (Salt Lake City, Utah); Gregory Clark (Salt Lake City, Utah); Christopher Duncan (Salt Lake City, Utah); Jacob Nieveen (Salt Lake City, Utah) |
| ABSTRACT | A technology is described for determining an intended movement from neuromuscular signals. An example method (800) includes receiving electromyography (EMG) data corresponding to single-ended channels of an electrode array (810), where EMG signals are detected by electrodes comprising the single-ended channels of the electrode array and the EMG signals are converted to the EMG data. Determining differential channel pairs for the single-ended channels of the electrode array (820) and extracting feature data from the EMG data of the differential channel pairs (830). Thereafter a feature data set is selected from the feature data of the differential channel pairs (840) and the feature data set is input to a decode model configured to correlate the feature data set to an intended movement (850). Decode output is received from the decode model indicating the intended movement (860) and the decode output is provided to a device (870). |
| FILED | Tuesday, August 01, 2017 |
| APPL NO | 16/322855 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/389 (20210101) Original (OR) Class A61B 2562/046 (20130101) A61B 2562/0252 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023922 | Dhau et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Molekule Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jaspreet S. Dhau (San Francisco, California); Chatura Wickramaratne (San Francisco, California) |
| ABSTRACT | A system for removing a coating from an underlying layer can include a wave-based weakening system configured to weaken the coating by decreasing a coupling force between the coating and the substrate, a coating removal mechanism configured to remove the weakened coating from the underlying layer, and a sensor configured to determine a property associated with the coating. A method for removing a coating from an underlying layer can include generating a weakened coating and removing the weakened coating. |
| FILED | Tuesday, December 10, 2019 |
| APPL NO | 17/296902 |
| CURRENT CPC | Cleaning in General; Prevention of Fouling in General B08B 7/04 (20130101) B08B 7/005 (20130101) B08B 7/028 (20130101) Original (OR) Class B08B 7/0071 (20130101) B08B 13/00 (20130101) B08B 2220/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024325 | Pettey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Response Technologies, LLC (Coventry, Rhode Island) |
| ASSIGNEE(S) | Response Technologies, LLC (Coventry, Rhode Island) |
| INVENTOR(S) | David Allen Pettey (Westport, Massachusetts); Edmund F. Bard (Cumberland, Rhode Island); Lao Vang (Providence, Rhode Island) |
| ABSTRACT | A fuel cell containing fuel for an aircraft includes an innermost layer configured to contact the fuel, an outermost layer and a containment gel formed from isocyanate and polyol interposed between the innermost and outermost layers. The containment gel is configured to self-seal a ballistically formed hole therein, thereby reducing leakage of the fuel from the fuel cell. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/228993 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 1/00 (20130101) B32B 5/02 (20130101) B32B 7/12 (20130101) B32B 27/12 (20130101) B32B 27/40 (20130101) B32B 2250/40 (20130101) B32B 2307/762 (20130101) B32B 2605/18 (20130101) Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/71 (20190201) B60L 50/72 (20190201) Original (OR) Class B60L 2200/10 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025195 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinsong Huang (Chapel Hill, North Carolina); Guang Yang (Chapel Hill, North Carolina); Wuqiang Wu (Chapel Hill, North Carolina) |
| ABSTRACT | Described herein is an ink solution, comprising: i. a composition having the formula ABX3; ii. a compound having the formula NH2—R1—NH2; and iii. a solvent. Methods for producing polycrystalline perovskite films using the ink solutions described herein in a fast blading process and the use of the films in photoactive and photovoltaic applications are additionally described. |
| FILED | Tuesday, January 14, 2020 |
| APPL NO | 17/422842 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 17/42 (20130101) C03C 17/3447 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/033 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/448 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025209 | WEBSTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean C. WEBSTER (Fargo, North Dakota); Teluka GALHENAGE (Chestnut Hill, Massachusetts); Ryan BURGETT (Maple Grove, Minnesota) |
| ABSTRACT | The invention relates to a curable amphiphilic siloxane polyurethane coating composition. The invention also relates to methods of making and using the curable amphiphilic siloxane polyurethane coating composition of the invention. The invention also relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the use of the curable amphiphilic siloxane polyurethane coating composition of the invention. |
| FILED | Friday, December 11, 2020 |
| APPL NO | 17/119334 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/10 (20130101) C08G 18/61 (20130101) C08G 18/78 (20130101) C08G 18/771 (20130101) C08G 18/3221 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1675 (20130101) C09D 5/1687 (20130101) C09D 7/63 (20180101) C09D 175/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025257 | Stracuzzi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Luis Stand Stracuzzi (Knoxville, Tennessee); Mao-Hua Du (Knoxville, Tennessee); Edgar V. Van Loef (Watertown, Massachusetts); Merry A. Koschan (Knoxville, Tennessee); Mariya Zhuravleva (Knoxville, Tennessee); Charles L. Melcher (Oak Ridge, Tennessee); Kanai S. Shah (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis Stand Stracuzzi (Knoxville, Tennessee); Mao-Hua Du (Knoxville, Tennessee); Edgar V. Van Loef (Watertown, Massachusetts); Merry A. Koschan (Knoxville, Tennessee); Mariya Zhuravleva (Knoxville, Tennessee); Charles L. Melcher (Oak Ridge, Tennessee); Kanai S. Shah (Watertown, Massachusetts) |
| ABSTRACT | Ternary transition metal halides are described herein. The ternary transition metal halides may be used as scintillator materials. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240344 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/62 (20130101) C09K 11/616 (20130101) Original (OR) Class C09K 11/7733 (20130101) Measurement of Nuclear or X-radiation G01T 1/2018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025267 | Safir et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zymergen Inc. (Emeryville, California); Kent State University (Kent, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Safir (Berkeley, California); Shilpa Naresh Raja (Emeryville, California); Arjan Zoombelt (Emeryville, California); Robert J. Twieg (Kent, Ohio); Pawan Nepal (Kent, Ohio); Ashani Wedige-Fernando (Kent, Ohio); Peter Palffy-Muhoray (Kent, Ohio) |
| ABSTRACT | The disclosure discusses chiral dopants for liquid-crystalline materials. Chiral dopants can be bioreachable compounds, i.e. compounds produced from microbes through fermentation. Chiral dopants can also include bioreachable materials that are further modified by chemical synthetic steps. Chiral dopants as discussed herein can include biomolecules such as glycyrrhetinic acid (1), S-narigenin (2), shikimic acid (3), alpha-phellandrene (4), betulin (5), malic acid (6), valencene (7), or nootkatone (8), and any stereoisomers or chemically modified derivatives thereof. The disclosure further shows optical properties of such compounds in a liquid-crystalline material. |
| FILED | Friday, December 06, 2019 |
| APPL NO | 17/299777 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 19/588 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025395 | Anderson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel G. Anderson (Framingham, Massachusetts); Robert Alexander Wesselhoeft (Boston, Massachusetts); Piotr S. Kowalski (Allston, Massachusetts) |
| ABSTRACT | Methods and constructs for engineering circular RNA are disclosed. In some embodiments, the methods and constructs comprise a vector for making circular RNA, the vector comprising the following elements operably connected to each other and arranged in the following sequence: a.) a 5′ homology arm, b.) a 3′ group I intron fragment containing a 3′ splice site dinucleotide, c.) optionally, a 5′ spacer sequence, d.) a protein coding or noncoding region, e.) optionally, a 3′ spacer sequence, f) a 5′ Group I intron fragment containing a 5′ splice site dinucleotide, and g.) a 3′ homology arm, the vector allowing production of a circular RNA that is translatable or biologically active inside eukaryotic cells. Methods for purifying the circular RNA produced by the vector and the use of nucleoside modifications in circular RNA produced by the vector are also disclosed. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492512 |
| CURRENT CPC | Peptides C07K 16/2803 (20130101) C07K 2317/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/85 (20130101) Original (OR) Class C12N 2015/859 (20130101) C12N 2015/8518 (20130101) C12N 2800/70 (20130101) C12N 2800/107 (20130101) C12N 2800/202 (20130101) C12N 2840/55 (20130101) C12N 2840/60 (20130101) C12N 2840/203 (20130101) C12N 2999/007 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025404 | PERKINS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CarryGenes Bioengineering (Savannah, Georgia) |
| ASSIGNEE(S) | CarryGenes Bioengineering (Savannah, Georgia) |
| INVENTOR(S) | Edward PERKINS (Savannah, Georgia); Amy GREENE (Savannah, Georgia) |
| ABSTRACT | The present invention encompasses compositions and methods to allow one to monitor formation of synthetic chromosomes in real-time via standardized fluorescent technology, eliminating the need for cumbersome, expensive, and possibly mutagenic analysis. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/482307 |
| CURRENT CPC | Peptides C07K 2319/60 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/90 (20130101) Original (OR) Class C12N 2800/208 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025425 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Haitian Zhang (Lafayette, Indiana); Fan Zuo (Terre Haute, Indiana); Feiran Li (West Lafayette, Indiana); Jong Hyun Choi (West Lafayette, Indiana); Shriram Ramanathan (West Lafayette, Indiana) |
| ABSTRACT | Disclosed herein is an ultralow concentration sensor of biomarkers, and the use thereof to help heath industry, medical centers and food industry to sense biomarkers by catalyst assisted charge transfer from the biomarkers to the sensor device, resulting increased electrical resistance of the sensor. Specifically, perovskite nickelate RNiO3 is used to sense biological material facilitated by specific enzymatic activity in the proximity. |
| FILED | Tuesday, December 10, 2019 |
| APPL NO | 17/311707 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1486 (20130101) A61B 5/14532 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) Original (OR) Class C12Q 1/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025444 | Samusik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikolay Samusik (Mountain View, California); Garry P. Nolan (Redwood City, California); Yury Goltsev (Stanford, California); David Robert McIlwain (Palo Alto, California) |
| ABSTRACT | A method for analyzing planar sample is provided. In some cases the method comprises: (a) labelling the planar sample with a capture agent that is linked to a nucleic acid, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the nucleic acid, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185757 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6804 (20130101) C12Q 1/6818 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025463 | Abudayyeh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Omar Abudayyeh (Cambridge, Massachusetts); James Joseph Collins (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Feng Zhang (Cambridge, Massachusetts); Eric S. Lander (Cambridge, Massachusetts); Aviv Regev (Cambridge, Massachusetts) |
| ABSTRACT | The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect both DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495219 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6804 (20130101) C12Q 1/6827 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 1/6888 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025673 | Michaelchuck et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Navy (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Michaelchuck (Alexandria, Virginia); Scott Ramsey (Fredericksburg, Virginia); Christopher Strem (Alexandria, Virginia) |
| ABSTRACT | A rapidly deployable structure comprising a first hub, a second hub, a plurality of legs and a rod connected to the first hub. The first hub includes a first plurality of recesses. The second hub includes a second plurality of recesses and an alignment guide. Each of the plurality of legs is connected to the first hub and the second hub. The rod connected is to the first hub and comprises a plurality of pins that are movable between an extended state and a retracted state. In the extended state, pins protrude from the rod. In a retracted state, the pins are retracted within the rod. The first hub is movable relative to the second hub between a first state in which the rod is disposed above the alignment guide in an axial direction defined by an opening in the alignment guide and a second state in which a portion of the rod comprising the plurality of pins is located below the alignment guide in the axial direction. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/386513 |
| CURRENT CPC | Walking Sticks; Umbrellas; Ladies\' or Like Fans A45B 23/00 (20130101) A45B 25/02 (20130101) A45B 25/06 (20130101) A45B 25/10 (20130101) A45B 2023/0006 (20130101) Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General E04H 15/28 (20130101) E04H 15/48 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025835 | Carmody et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph A. Carmody (Tucson, Arizona); Benjamin C. Hulbert (Tucson, Arizona); Ryan J. Paffenroth (Tucson, Arizona); Andrew J. Harris (Tucson, Arizona) |
| ABSTRACT | A rocket motor for a gun-fired projectile is configured stiffen the burnable propellant in the rocket motor during burning and/or protect the rocket motor from the pressure that occurs during firing of the projectile from the gun. The rocket motor may include a rigid structure that is integrated into the burnable propellant grain to stabilize the burnable propellant grain during burning of the burnable propellant grain. The rigid structure has a matrix or truss-like shape that extends into the depth of the burnable propellant grain. The rocket motor may include a baffled end cap that covers a nozzle of the rocket motor. The end cap defines a baffled path through the end cap to dampen gas flow into the nozzle and prevent particles of the gun propellant from entering the rocket motor. A rocket motor may implement the rigid structure or the baffled end cap, or both structures. |
| FILED | Wednesday, February 24, 2021 |
| APPL NO | 17/184470 |
| CURRENT CPC | Jet-propulsion Plants F02K 9/26 (20130101) F02K 9/32 (20130101) Original (OR) Class Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 15/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025941 | Olson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bell Textron Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | Bell Textron Inc. (Fort Worth, Texas) |
| INVENTOR(S) | Eric Stephen Olson (Fort Worth, Texas); David Andrew Prater (Hurst, Texas) |
| ABSTRACT | A failsafe multimode clutch assembly positioned in a powertrain of a rotorcraft. The clutch assembly includes a freewheeling having a driving mode in which torque applied to the input race is transferred to the output race and an overrunning mode in which torque applied to the output race is not transferred to the input race. A bypass assembly has an engaged position that couples the input and output races of the freewheeling unit. An actuator assembly uses pressurized lubricating oil to shift the bypass assembly between the engaged position and a disengaged position. A lock assembly enables and disables actuation of the bypass assembly. In the disengaged position, the overrunning mode of the freewheeling unit enables a unidirectional torque transfer mode of the clutch assembly. In the engaged position, the overrunning mode of the freewheeling unit is disabled such that the clutch assembly is configured for bidirectional torque transfer. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494356 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/14 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 35/04 (20130101) B64D 35/08 (20130101) B64D 2027/026 (20130101) Couplings for Transmitting Rotation; Clutches; Brakes F16D 11/14 (20130101) F16D 25/14 (20130101) F16D 25/061 (20130101) F16D 25/083 (20130101) F16D 41/04 (20130101) F16D 41/07 (20130101) Original (OR) Class F16D 41/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026192 | Sinclair et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laura Cathleen Sinclair (Boulder, Colorado); Nathan Reynolds Newbury (Boulder, Colorado); William Charles Swann (Boulder, Colorado); Jean-Daniel Deschenes (Chatelets, Canada) |
| ABSTRACT | A synchronizer for synchronizing transfer over an optical link includes a frequency reference oscillator; a tracking optical timing source; a tracking comb signal; a signal processor-controller; a comb timing discriminator; a clock frequency comb; a bidirectional terminal; a time-frequency offset measurement system; and a second comb timing discriminator. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209285 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02004 (20130101) Original (OR) Class G01B 9/02008 (20130101) G01B 9/02014 (20130101) G01B 9/02069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026199 | Rastegar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Omnitek Partners LLC (RONKONKOMA, New York) |
| ASSIGNEE(S) | Omnitek Partners LLC (RONKONKOMA, New York) |
| INVENTOR(S) | Jahangir S. Rastegar (Stony Brook, New York) |
| ABSTRACT | A method for determining angular orientation of an object in two or more directions. The method includes: generating a scanning polarized RF source signal; receiving the scanning polarized RF source signal at one or more cavities of a sensor disposed on the object; measuring the scanning polarized RF source signal at a first portion of the sensor; reflecting the scanning polarized RF source signal toward a second portion of the sensor; measuring the scanning polarized RF source signal at the second portion of the sensor; and determining the angular orientation of the object in the two or more directions based on the measured signal at the first and second portions of the sensor. |
| FILED | Sunday, March 14, 2021 |
| APPL NO | 17/200842 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 15/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026279 | Zeibel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason G. Zeibel (Fairfax Station, Virginia); William Paul Blase (Alexandria, Virginia); John K. Delaney (Bethesda, Maryland) |
| ABSTRACT | A cold-tunnel system is disclosed for recovery of thermal emissivity of extended targets. The cold-tunnel system is comprised of an infrared camera having a thermal imaging lens; an aperture plate having a hole aligned with the thermal imaging lens; four cold-wall panels assembled in a box pattern as a cold-tunnel assembly to form a cold tunnel; an air-blowing desiccator affixed to each cold-wall panel; an external liquid chiller to chill a reservoir of working fluid; a target under test; and an extended source blackbody reference disposed directly behind the target under test. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361499 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/061 (20130101) Original (OR) Class G01J 5/0806 (20130101) G01J 2005/0077 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026287 | Murray et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph B. Murray (Ellicott City, Maryland); Brandon F. Redding (University Park, Maryland) |
| ABSTRACT | A dynamic Brillouin fiber sensor that is immune to fluctuations in the power, frequency, or polarizing state of the pump and probe beams is described herein. A new measurand that combines information from the complex Stokes and anti-Stokes interactions is provided to extract the absolute Brillouin frequency shift while rejecting the majority of noise sources that may limit the performance of current slope-assisted Brillouin optical time domain analysis systems. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/383263 |
| CURRENT CPC | Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 3/00 (20130101) G01K 11/322 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026340 | Di Carlo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Dino Di Carlo (Los Angeles, California); Daniel R. Gossett (Los Angeles, California); Henry T.K. Tse (San Francisco, California) |
| ABSTRACT | A system is disclosed that enables the automated measurement of cellular mechanical parameters at high throughputs. The microfluidic device uses intersecting flows to create an extensional flow region where the cells undergo controlled stretching. Cells are focused into streamlines prior to entering the extensional flow region. In the extensional region, each cell's deformation is measured with an imaging device. Automated image analysis extracts a range of independent biomechanical parameters from the images. These may include cell size, deformability, and circularity. The single cell data that is obtained may then be used to in a variety of ways. Scatter density plots of deformability and circularity may be developed and displayed for the user. Mechanical parameters such as deformability and circularity may be gated or thresholded to identify certain cells of interest or sub-populations of interest. Similarly, the mechanical data obtained using the device may be used as cell signatures. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496758 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 3/502776 (20130101) B01L 2200/0605 (20130101) B01L 2200/0647 (20130101) B01L 2200/0652 (20130101) B01L 2300/0654 (20130101) B01L 2300/0864 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) G01N 15/1459 (20130101) G01N 15/1463 (20130101) Original (OR) Class G01N 15/1484 (20130101) G01N 33/487 (20130101) G01N 33/574 (20130101) G01N 2015/0065 (20130101) G01N 2015/1495 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 99/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026580 | Crouch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Amida Technology Solutions, Inc. (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfred Larry Crouch (Cedar Park, Texas); Peter Lawrence Levin (Silver Springs, Maryland); John David Akin (Plano, Texas); Adam Wade Ley (Allen, Texas); Matthew McKinnon Ritonia (Arlington, Virginia); Wesley Layton Ellington (Dallas, Texas); Maria Anne Spasojevic (Palo Alto, California) |
| ABSTRACT | A method and system for analysis of a facility may include providing an emulation host system, generating a pristine circuit model on the emulation host system, inserting a first hardware trojan model, emulating operation of the golden circuit model, and emulating operation of the first hardware trojan model, and determine a set of machine-learning models, detecting the presence of an unknown trojan as a function of the set of machine learning models and using the same to authenticate the integrity of a GPS signal. |
| FILED | Sunday, December 27, 2020 |
| APPL NO | 17/134441 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/23 (20130101) Original (OR) Class G01S 19/42 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026727 | Sitter, Jr. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (Waltham, Massachusetts) |
| INVENTOR(S) | David N. Sitter, Jr. (El Segundo, California) |
| ABSTRACT | A beam splitter configured to split incident light includes a polarization grating having a liquid crystal layer and a reflective sub-aperture beam splitter. The liquid crystal layer is configured to switch between an “on” state and an “off” state in response to an applied voltage. In the “off” state, the polarization grating angularly deviates and polarizes a portion of received incident light passing therethrough. In the “on” state, crystals of the polarization grating align with the incident light, allowing it to pass therethrough unimpeded and unpolarized. The beam splitter includes a plurality of sub-aperture mirrors which are spaced at randomly varying distances from one another, the mirrors being configured to reflect a portion of the incident light. |
| FILED | Thursday, July 23, 2020 |
| APPL NO | 16/937224 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/3016 (20130101) G02B 27/283 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026932 | Streeter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander D. Streeter (Concord, New Hampshire); David E. Altobelli (Hollis, New Hampshire); N. Christopher Perry (Manchester, New Hampshire) |
| ABSTRACT | A control unit system. The system includes a control unit which includes a control unit charging interface, at least one magnet located proximate to the control unit charging interface, at least one actuator, a detachable manifold including at least one magnet, fluidly coupled to the at least one actuator, a pump connected to the at least one actuator for causing actuation thereof, and a control system for controlling the pump, wherein the control system controls the pump to actuate the at least one actuator at least in response to a signal received by the control system. The system also includes a recharging device configured to receive the control unit, the recharging device including a reed switch, wherein when the magnet in the control unit is located proximate to the reed switch, the switch is activated. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492186 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/7843 (20130101) A61F 5/012 (20130101) A61F 5/024 (20130101) A61F 5/34 (20130101) A61F 2002/5083 (20130101) Pipes; Joints or Fittings for Pipes; Supports for Pipes, Cables or Protective Tubing; Means for Thermal Insulation in General F16L 39/00 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 15/02 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 7/0623 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026972 | Shah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Parth Sanjaybhai Shah (Bangalore, India); Ranjal Gautham Shenoy (Bangalore, India); Vaidyanathan Srinivasan (Bangalore, India); Alper Buyuktosunoglu (White Plains, New York); Augusto Vega (Mount Vernon, New York); Pradip Bose (Yorktown Heights, New York) |
| ABSTRACT | A method, computer program product, and/or system associates a number of tokens with a plurality of frequency domains (for example, cores) of a central processing unit (CPU) computer chip. The number of tokens allotted to the CPU is based on the CPU power budget. Cores are organized as a ring topology. A token pool traverses the ring, picks up excess tokens from cores having excess tokens, and gives the tokens to cores that need additional tokens. Tokens acquired by a core allows the core to increase operating frequency by an increment represented by the tokens. Consequently, power usage is weighted toward heavily loaded cores and away from lightly loaded cores. Overall power usage of the CPU remains within a power budget. The method budgets power optimally to sustain turbo frequencies for longer durations by not allowing control units to increase frequency in absence of any useful high frequency benefiting workload. |
| FILED | Monday, July 27, 2020 |
| APPL NO | 16/940171 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/263 (20130101) G06F 1/324 (20130101) Original (OR) Class G06F 1/3237 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220027775 | Cornelio et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cristina Cornelio (Kilchberg, Switzerland); Lior Horesh (North Salem, New York); Achille Belly Fokoue-Nkoutche (White Plains, New York); Sanjeeb Dash (Croton on Hudson, New York) |
| ABSTRACT | Aspects of the invention include obtaining a set of data that includes inputs and outputs to be modelled and performing a symbolic regression to find a symbolic model that fits the inputs and the outputs of the set of data. The symbolic model is a symbolic expression discovered by the symbolic regression in a search space. Automated reasoning is performed to affect a final symbolic model that is used to obtain new outputs from new inputs based on the final symbolic model. |
| FILED | Tuesday, July 21, 2020 |
| APPL NO | 16/934574 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/00 (20130101) G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220027811 | Agrawal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Anand Agrawal (Irvine, California); Benny Cheng (Chino Hills, California); James Dai (Crane, Indiana); Nicholas Hymer (Upland, California); Raymond Ward (Cypress, California) |
| ABSTRACT | Systems and methods for part prioritization in accordance with embodiments of the invention are illustrated. One embodiment includes a method for determining part priorities. The method includes steps for receiving part data for a set of one or more parts, the part data includes part failure data and part repair data, computing predicted lifecycle data based on the received part data, determining failure impact data based on the received part data, and generating an output based on the predicted lifecycle data and the failure impact data. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/385190 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/20 (20130101) G06Q 10/0635 (20130101) Original (OR) Class G06Q 10/06313 (20130101) G06Q 50/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220028533 | KULKARNI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KONINKLIJKE PHILIPS N.V. (EINDHOVEN, Netherlands) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chaitanya KULKARNI (Bangalore, India); Mohammad Shahed SOROWER (Natick, Massachusetts); Bryan CONROY (Garden City South, New York); Claire Yunzhu ZHAO (Cambridge, Massachusetts); David Paul NOREN (Sharon, Massachusetts); Kailash SWAMINATHAN (Chennai, India); Ting FENG (Cambridge, Massachusetts); Kristen TGAVALEKOS (Cambridge, Massachusetts); Daniel Craig MCFARLANE (Reading, Massachusetts); Erina GHOSH (Boston, Massachusetts); Vinod KUMAR (Bangalore, India); Vikram SHIVANNA (Bangalore, India); Shraddha BARODIA (Bangalore, India); Emma Holdrich SCHWAGER (Cambridge, Massachusetts); Prasad RAGHOTHAM VENKAT (Bangalore, India) |
| ABSTRACT | A method for processing medical information includes identifying a first patient in a first state, identifying a second patient in a second state, calculating a first risk score for the first patient, calculating a first risk score for the second patient, and determining a risk prone area in a medical facility based on the first risk score for the first patient and the first risk score for the second patient. The first state is an infected state and the second state is different from the first state. The first risk score of the first patient provides an indication of a severity of the infected state of the first patient, and the first risk score of the second patient provides an indication of the second patient being infected by the first patient. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 17/267615 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/20 (20180101) Original (OR) Class G16H 50/30 (20180101) G16H 50/80 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220028621 | GOLOVINA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Iryna S. GOLOVINA (Philadelphia, Pennsylvania); Aleksandr V. PLOKHIKH (Philadelphia, Pennsylvania); Jonathan E. SPANIER (Bala Cynwyd, Pennsylvania); Mattias FALMBIGL (Syosset, New York) |
| ABSTRACT | Provided is the dielectric response of atomic layer-deposited and annealed polymorphic BaTiO3 and BaTiO3—AlO3 bi-layer thin films based on nanocrystalline BaTiO3 containing the perovskite and hexagonal polymorphs. Also provided are BaTiCb films having tuned Curie temperatures. Also provide are nano-grained films, comprising: a BaTiO3 film component comprising a Ba/Ti ratio of between about 0.8 and 1.06, a transition temperature of the nano-grained film being dependent on the Ba/Ti ratio, and the nano-grained film exhibiting a diffused phase transition, optionally whereby a temperature density of a dielectric constant of the nano-grained film is minimized. |
| FILED | Wednesday, November 13, 2019 |
| APPL NO | 17/293558 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 4/10 (20130101) H01G 7/04 (20130101) Original (OR) Class H01G 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029293 | Mak et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United State, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bing Mak (Marlboro, New Jersey); Adam Melber (Churchville, Maryland); Daniel Heinz (Perry Hall, Maryland); Michael Brennan (North East, Maryland) |
| ABSTRACT | Various embodiments that pertain to a loop antenna are described. The loop antenna can be a single loop antenna that switches between a first phase and a second phase. While operating at different phases, the loop antenna can function at the same frequency. The loop antenna can observe a response to the frequency at the first phase and the frequency at the second phase. This can provide a wider range of information over operation in a single phase. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496121 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029594 | XIANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intelligent Fusion Technology, Inc. (Germantown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingyu XIANG (Germantown, Maryland); Dan SHEN (Germantown, Maryland); Genshe CHEN (Germantown, Maryland); Khanh PHAM (Kirtland AFB, New Mexico) |
| ABSTRACT | Embodiments of the present disclosure provide a method, a device, and a storage medium for hybrid automatic gain control in a communication system. The method includes amplifying an input signal to generate an amplified signal which is converted into a plurality of output signals; obtaining a moving average amplitude of a plurality of output signals of a current input signal; and calculating a signal amplitude difference according to the moving average amplitude and a desired output signal amplitude level; calculating a signal amplitude ratio according to a plurality of output signals of two previous output signal blocks and AGC gains corresponding to the plurality of output signals of the two previous output signal blocks; obtaining a step size according to the signal amplitude difference and the signal amplitude ratio; and calculating an AGC gain of the current input signal according to the step size and a corresponding previous AGC gain. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/382838 |
| CURRENT CPC | Amplifiers H03F 3/21 (20130101) Control of Amplification H03G 3/3089 (20130101) Original (OR) Class H03G 2201/103 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029642 | Helmboldt |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Helmboldt (Crofton, Maryland) |
| ABSTRACT | A radio telescope array is provided for tracking radio sources that are essentially infinitely stable and resilient transmitters. The radio telescope array may be implemented with just a few antennas in different applications, such as an ionospheric density gradiometer or an imaging scintillometer. Data received at the radio telescope array may be utilized for various purposes, for example, to analyze ionospheric variations, study bursts of radio emission or monitor cosmic objects. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/383233 |
| CURRENT CPC | Transmission H04B 1/0003 (20130101) Original (OR) Class H04B 7/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029839 | Flajslik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mario Flajslik (Hopkinton, Massachusetts); Eric R. Borch (Fort Collins, Colorado); Michael A. Parker (Santa Clara, California); Richard J. Dischler (Bolton, Massachusetts) |
| ABSTRACT | Technologies for densely packaging network components for large scale indirect topologies include group of switches. The group of switches includes a stack of node switches that includes a first set of ports and a stack of global switches that includes a second set of ports. The stack of node switches are oriented orthogonally to the stack of global switches. Additionally, the first set of ports are oriented towards the second set of ports and the node switches are connected to the global switches through the first and second sets of ports. Other embodiments are also described and claimed. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494712 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 12/12 (20130101) Original (OR) Class H04L 12/44 (20130101) H04L 41/12 (20130101) H04L 41/0803 (20130101) H04L 45/12 (20130101) H04L 49/15 (20130101) Wireless Communication Networks H04W 40/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029845 | Klenk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NVIDIA Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Klenk (San Jose, California); Nan Jiang (Santa Clara, California); Larry Robert Dennison (Menden, Massachusetts); Gregory M. Thorson (Palo Alto, California) |
| ABSTRACT | A network device configured to perform scalable, in-network computations is described. The network device is configured to process pull requests and/or push requests from a plurality of endpoints connected to the network. A collective communication primitive from a particular endpoint can be received at a network device. The collective communication primitive is associated with a multicast region of a shared global address space and is mapped to a plurality of participating endpoints. The network device is configured to perform an in-network computation based on information received from the participating endpoints before forwarding a response to the collective communication primitive back to one or more of the participating endpoints. The endpoints can inject pull requests (e.g., load commands) and/or push requests (e.g., store commands) into the network. A multicast capability enables tasks, such as a reduction operation, to be offloaded to hardware in the network device. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495547 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5083 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 12/18 (20130101) H04L 12/1886 (20130101) Original (OR) Class H04L 45/74 (20130101) H04L 47/20 (20130101) H04L 47/39 (20130101) H04L 47/806 (20130101) H04L 67/26 (20130101) H04L 67/2842 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029897 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Han (Bridgewater, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Muhammad Bilal Anwer (Branchburg, New Jersey); Zhi-Li Zhang (Eden Prairie, Minnesota); Yang Zhang (Saint Paul, Minnesota) |
| ABSTRACT | Systems, computer-readable media, and methods are disclosed for parallel data processing for service function chains with network functions spanning multiple servers. An example system includes a first server hosting a first network function of a service function chain, a second server hosting a second network function of the service function chain, a mirror function deployed in a first switch to replicate a plurality of packets received by the system and to send respective copies of the plurality of packets to the first network function and to at least one of the second network function and a third network function of the service function chain, and a merge function deployed in a second switch to merge respective outputs of the first network function and the at least one of the second network function and the third network function. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498440 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/5054 (20130101) Original (OR) Class H04L 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029926 | Le et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thai Franck Le (White Plains, New York); Erich M. Nahum (New York, New York) |
| ABSTRACT | A queue management method, system, and recording medium include Selective Acknowledgments (SACK) examining to examine SACK blocks of a forwarder to selectively drop packets in a forward flow queue based on a reverse flow queue and MultiPath Transmission Control Protocol (MPTCP) examining configured to perform a first examining to examine multipath headers to recognize MPTCP flows based on a comparison between two subflows being a part of a same superflow and a second examining to examine the reverse flow queue to determine if redundant data has been sent based on a result of the first examining, a packet in the forward flow queue from a prior transmission being dropped from the forward flow queue sent from the forwarder to a receiver if a metadata of the packet does not match a metadata of an acknowledged packet in the reverse flow queue. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345289 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/24 (20130101) H04L 47/12 (20130101) H04L 47/323 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220030013 | Crouch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Amida Technology Solutions, Inc. (Washinton, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfred Larry Crouch (Cedar Park, Texas); Peter Lawrence Levin (Silver Springs, Maryland); John David Akin (Plano, Texas); Adam Wade Ley (Allen, Texas); Matthew McKinnon Ritonia (Arlington, Virginia); Wesley Layton Ellington (Dallas, Texas); Maria Anne Spasojevic (Palo Alto, California) |
| ABSTRACT | A method and system for analysis of a facility may include providing an emulation host system, generating a pristine circuit model on the emulation host system, inserting a first hardware trojan model, emulating operation of the golden circuit model, and emulating operation of the first hardware trojan model, and determine a set of machine-learning models, detecting the presence of an unknown trojan as a function of the set of machine learning models. |
| FILED | Sunday, December 27, 2020 |
| APPL NO | 17/134438 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2379 (20190101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220030131 | Zeibel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason G. Zeibel (Fairfax Station, Virginia); William Paul Blase (Alexandria, Virginia); John K. Delaney (Bethesda, Maryland) |
| ABSTRACT | An apparatus detects a transient thermal gradient in a substrate. The apparatus is comprised of an electromagnetic radiation source configured to emit source electromagnetic radiation; a fast shutter configured to block the source electromagnetic radiation when closed, and open in response to a command to pulse the source electromagnetic radiation; a substrate support that supports a substrate disposed to emit a pulsed radiation from a back side of the substrate when the source electromagnetic radiation is pulsed through the substrate; and a detector configured to face the back side of the substrate. The detector is used to detect a transient thermal gradient in the pulsed radiation. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/361389 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0834 (20130101) G01J 2005/0077 (20130101) Pictorial Communication, e.g Television H04N 1/32149 (20130101) Original (OR) Class H04N 5/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220022783 | Polsky et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); UNM Rainforest Innovations (Albuquerque, New Mexico) |
| ASSIGNEE(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); UNM Rainforest Innovations (Albuquerque, New Mexico) |
| INVENTOR(S) | Ronen Polsky (Albuquerque, New Mexico); Philip R. Miller (Albuquerque, New Mexico); Justin T. Baca (Albuquerque, New Mexico) |
| ABSTRACT | A microneedle device comprising a hollow microneedle protruding from the rim of an outer open holder can be used for the extraction of interstitial fluid (ISF). Dermal ISF can be extracted with the microneedle device with minimal pain and no blistering for human subjects. Extracted ISF volumes are sufficient for determining transcriptome and proteome signatures. Similar profiles in ISF, serum, and plasma samples, suggest that ISF can be a proxy for direct blood sampling. This minimally-invasive microneedle device enables real-time health monitoring applications using extracted ISF. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497831 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/14514 (20130101) Original (OR) Class A61B 5/15142 (20130101) A61B 5/150022 (20130101) A61B 5/150068 (20130101) A61B 5/150312 (20130101) A61B 5/150396 (20130101) A61B 5/150412 (20130101) A61B 5/150503 (20130101) A61B 5/150984 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220022883 | Ortega et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jonathan Hartman (Sacramento, California); Lawrence Livermore National Security, Inc. (Livermore, California); The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason M. Ortega (Pacifica, California); William J. Benett (Livermore, California); Ward Small (Livermore, California); Thomas S. Wilson (San Leandro, California); Duncan J. Maitland (College Station, Texas); Jonathan Hartman (Sacramento, California) |
| ABSTRACT | A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496328 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/12022 (20130101) A61B 17/12031 (20130101) A61B 17/12113 (20130101) Original (OR) Class A61B 17/12181 (20130101) A61B 2017/0061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023794 | Panaccione et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ION Clean Energy, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | ION Clean Energy, Inc. (Boulder, Colorado) |
| INVENTOR(S) | Charles Panaccione (Boulder, Colorado); Erik Everhardus Bernardus Meuleman (Boulder, Colorado); Gregory Allan Staab (Arvada, Colorado); Nathan R. Brown (Oslo, Norway) |
| ABSTRACT | A carbon dioxide capture system, fluid contactor and method are disclosed. In embodiments, a gas-liquid contactor unit is disposed along a process fluid flow axis and includes a contactor of network flow diversions barriers with flow voids for movement of process fluids therebetween. A plurality of heat exchange channels are provided in the flow diversion barriers to transport a heat exchange fluid through the contactor network. A heat exchange feed channel is provided to deliver feed of the heat exchange fluid to the heat exchange channels at multiple feed locations spaced along the flow axis. At least one heat exchange bypass channel may extend beyond the multiple feed locations to deliver a portion of the feed of the heat exchange fluid to additional heat exchange channels located downstream from the multiple feed locations for the heat exchange channels. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494205 |
| CURRENT CPC | Separation B01D 47/14 (20130101) Original (OR) Class B01D 53/18 (20130101) B01D 53/1475 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023813 | Ye et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Congwang Ye (Livermore, California); Roger D. Aines (Livermore, California); Sarah E. Baker (Dublin, California); Caitlyn Christian Cook (Livermore, California); Eric B. Duoss (Dublin, California); Joshua D. Kuntz (Livermore, California); Elaine Lee (Brooklyn, New York); James S. Oakdale (Castro Valley, California); Andrew J. Pascall (Livermore, California); Joshuah K. Stolaroff (Oakland, California); Marcus A. Worsley (Hayward, California); Carlos J. Martinez (West Layfayette, Indiana) |
| ABSTRACT | Fabrication of functional polymer-based particles by crosslinking UV-curable polymer drops in mid-air and collecting crosslinked particles in a solid container, a liquid suspension, or an air flow. The particles can contain different phases in the form or layered structures that contain one to multiple cores, or structures that are blended with dissolved or emulsified smaller domains. A curing system produces ultraviolet rays that are directed onto the particles in the jet stream from one side. A reflector positioned on other side of the jet stream reflects the ultraviolet rays back onto the particles in the jet stream. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/450731 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 2/04 (20130101) Original (OR) Class B01J 13/14 (20130101) B01J 13/206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023817 | Aytug et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tolga Aytug (Knoxville, Tennessee); Kai Li (Farragut, Tennessee); Meghan E. Lamm (Oak Ridge, Tennessee); Diana Hun (Lenoir City, Tennessee); Kaushik Biswas (Davis, California) |
| ABSTRACT | An insulation medium invention includes a plurality of microspheres. Each microsphere comprises a porous core comprising a porous core material and having an exterior surface, a gas within the porous core, and a coating layer coating all of the exterior surface of the porous core. The coating layer comprises a coating material which transitions from a first state to a second state. In the first state, the coating material is permeable to the gas. In the second state the material is impermeable to the gas. The coating material in the second state is configured to encapsulate and maintain partial vacuum of the gas inside the porous core. In one embodiment, in the second state the coating is impermeable to air. Insulated structures, a method of making an insulation medium, a fluid storage media, and a method of delivering a fluid are also disclosed. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/384317 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0004 (20130101) A61K 9/5073 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/22 (20130101) B01J 13/203 (20130101) Original (OR) Class Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 27/10 (20130101) B32B 27/20 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 20/0032 (20130101) C04B 20/1029 (20130101) C04B 2111/00612 (20130101) Pulp Compositions; Preparation Thereof Not Covered by Subclasses D21C or D21D; Impregnating or Coating of Paper; Treatment of Finished Paper Not Covered by Class B31 or Subclass D21G; Paper Not Otherwise Provided for D21H 17/74 (20130101) General Building Constructions; Walls, e.g Partitions; Roofs; Floors; Ceilings; Insulation or Other Protection of Buildings E04B 1/806 (20130101) Structural Elements; Building Materials E04C 2/288 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023918 | Kumar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sortera Alloys, Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | Sortera Alloys, Inc. (Fort Worth, Texas) |
| INVENTOR(S) | Nalin Kumar (Fort Worth, Texas); Manuel Gerardo Garcia, JR. (Lexington, Kentucky); Kanishka Tyagi (Meerut, India) |
| ABSTRACT | Systems and methods for classifying materials utilizing one or more sensor systems, which may implement a machine learning system in order to identify or classify each of the materials, which may then be sorted into separate groups based on such an identification or classification. The machine learning system may utilize a neural network, and be previously trained to recognize and classify certain types of materials. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495291 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024154 | Sinha et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanjiv Sinha (Champaign, Illinois); Placid M. Ferreira (Champaign, Illinois); Nenad Miljkovic (Urbana, Illinois); Manjunath C. Rajagopal (Champaign, Illinois); Gowtham Kuntumalla (McKinney, Texas); Akhilesh Sanjay Somani (McKinney, Texas) |
| ABSTRACT | An apparatus for fabricating a hybrid tube includes a rotatable mandrel and a first housing configured to translate alongside the rotatable mandrel while dispensing a first strip to be helically wound about the mandrel. The first housing includes an angle adjustment mechanism to control a dispensation angle of the first strip. The apparatus also includes least one energy or adhesive source for bonding overlapping strip portions on the rotatable mandrel and forming the hybrid tube. The at least one energy or adhesive source is configured for translation alongside the rotatable mandrel. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 17/379056 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/32 (20130101) Original (OR) Class Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2023/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024206 | Secor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ethan Benjamin Secor (Albuquerque, New Mexico); Adam Wade Cook (Albuquerque, New Mexico); Bryan James Kaehr (Albuquerque, New Mexico); Rebecca Rosa Tafoya (Corrales, New Mexico) |
| ABSTRACT | Aerosol jet printing is a popular digital fabrication method for flexible and hybrid electronics, but it lacks sophisticated process control architectures that would enable more widespread adoption in manufacturing environments. An optical measurement system can be used to track the aerosol density upstream of the printhead. For example, the measured optical extinction combined with the aerosol flow rate, is directly related to deposition rate and accurately predicts functional properties, for example electrical resistance. This real-time system offers a compelling solution for process drift and batch-to-batch variability, a valuable tool for more fundamental studies of the process science, and a viable technology to support real-time control of aerosol jet printing. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 16/935823 |
| CURRENT CPC | Typewriters; Selective Printing Mechanisms,, i.e Mechanisms Printing Otherwise Than From a Forme; Correction of Typographical Errors B41J 2/125 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024437 | Gosala et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dheeraj B. Gosala (Columbus, Indiana); Carlos A. Lana (Columbus, Indiana) |
| ABSTRACT | At least some embodiments of the present disclosure are directed to systems and methods of online power management for hybrid powertrains. In some embodiments, the hybrid powertrain control system is configured to conduct a brake-thermal-efficiency (BTE) estimation procedure when the powertrain is in operation by operating the hybrid powertrain at a plurality of speeds for a plurality of designated power levels and select certain BTE operating conditions to update the power management. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 16/935346 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 20/00 (20130101) Original (OR) Class B60W 2510/18 (20130101) B60W 2510/244 (20130101) B60W 2510/0657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024954 | ZHU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Board of Trustees of Northern Illinois University (DeKalb, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai ZHU (Littleton, Colorado); Tao XU (Naperville, Illinois) |
| ABSTRACT | The present disclosure relates to a composition that includes a sequestering material capable of binding a target material, where the sequestering material includes a first component that includes at least one of a functional group, a molecule, an oligomer, or a polymer, and the target material includes at least one of an element, a chemical, and/or a compound. In some embodiments of the present disclosure, the element may include at least one element from at least one of Rows 4, 5, 6, and 7 of the Periodic Table and/or an inner transition metal. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498268 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/3873 (20130101) C07F 9/4006 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 71/02 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/042 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/38 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025195 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinsong Huang (Chapel Hill, North Carolina); Guang Yang (Chapel Hill, North Carolina); Wuqiang Wu (Chapel Hill, North Carolina) |
| ABSTRACT | Described herein is an ink solution, comprising: i. a composition having the formula ABX3; ii. a compound having the formula NH2—R1—NH2; and iii. a solvent. Methods for producing polycrystalline perovskite films using the ink solutions described herein in a fast blading process and the use of the films in photoactive and photovoltaic applications are additionally described. |
| FILED | Tuesday, January 14, 2020 |
| APPL NO | 17/422842 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 17/42 (20130101) C03C 17/3447 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/033 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/448 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025257 | Stracuzzi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Luis Stand Stracuzzi (Knoxville, Tennessee); Mao-Hua Du (Knoxville, Tennessee); Edgar V. Van Loef (Watertown, Massachusetts); Merry A. Koschan (Knoxville, Tennessee); Mariya Zhuravleva (Knoxville, Tennessee); Charles L. Melcher (Oak Ridge, Tennessee); Kanai S. Shah (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis Stand Stracuzzi (Knoxville, Tennessee); Mao-Hua Du (Knoxville, Tennessee); Edgar V. Van Loef (Watertown, Massachusetts); Merry A. Koschan (Knoxville, Tennessee); Mariya Zhuravleva (Knoxville, Tennessee); Charles L. Melcher (Oak Ridge, Tennessee); Kanai S. Shah (Watertown, Massachusetts) |
| ABSTRACT | Ternary transition metal halides are described herein. The ternary transition metal halides may be used as scintillator materials. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240344 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/62 (20130101) C09K 11/616 (20130101) Original (OR) Class C09K 11/7733 (20130101) Measurement of Nuclear or X-radiation G01T 1/2018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025287 | SAHA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Basudeb SAHA (Newark, Delaware); Sibao LIU (Newark, Delaware); Angela M. NORTON (Newark, Delaware); Dionisios G. VLACHOS (Voorhees, New Jersey) |
| ASSIGNEE(S) | University of Delaware (Newark, Delaware) |
| INVENTOR(S) | Basudeb SAHA (Newark, Delaware); Sibao LIU (Newark, Delaware); Angela M. NORTON (Newark, Delaware); Dionisios G. VLACHOS (Voorhees, New Jersey) |
| ABSTRACT | Disclosed herein are lubricant compositions containing 75-99% by weight of a base oil that includes one or more branched aliphatic compounds having the following formula: R1R2HC—CH2—CHR3R4 (I) wherein R1 and R3 are independently selected from alkyl groups having 8 to 26 carbon atoms, and R2 and R4 are independently selected from the group consisting of H and alkyl groups having 5 to 7 carbon atoms, with a proviso that at least one of R2 and R4 is not hydrogen. The alkyl groups are substituted or unsubstituted, or branched or unbranched; R1 and R3 may be the same or different; and the total carbon content of the branched aliphatic compound of formula (I) is in the range of 26 to 66. The lubricant compositions also include an effective amount of one or more additives. Also, disclosed herein are processes for making such compositions and their uses in pharmaceutical and personal care products. |
| FILED | Tuesday, November 26, 2019 |
| APPL NO | 17/297027 |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 105/04 (20130101) Original (OR) Class C10M 169/04 (20130101) C10M 2203/0206 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2020/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025340 | Malik et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YIELD10 BIOSCIENCE, INC. (Woburn, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meghna Malik (Saskatoon, Canada); Jihong TANG (West Roxbury, Massachusetts); Kristi D. SNELL (Belmont, Massachusetts) |
| ABSTRACT | Transgenic plants having enhanced yield and having enhanced seed yield are disclosed. The transgenic plants are transformed with a transgenic polynucleotide encoding one or more metabolic enzymes. The metabolic enzymes can be from any biological source. The transgenic polynucleotide(s) comprises a nucleic acid sequences encoding the metabolic enzymes under the control of functional plant promoters, the one or more metabolic enzymes are targeted to the plastids by the addition of plastid targeting signals. Optionally the functional plant promoters are seed specific promoters and the metabolic enzymes are targeted to the plastids by the addition of plastid targeting peptide heterologous to the metabolic enzymes. Methods of making the transgenic plants and transgenic polynucleotides are disclosed. The magnitude of the increases in seed yield achieved with these transgenic plants are unprecedented. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498240 |
| CURRENT CPC | Peptides C07K 14/415 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) Original (OR) Class C12N 15/52 (20130101) C12N 15/8243 (20130101) C12N 15/8247 (20130101) C12N 15/8261 (20130101) Enzymes C12Y 101/01082 (20130101) Technologies for Adaptation to Climate Change Y02A 40/146 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025380 | Haushalter et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. Haushalter (Emeryville, California); Ee-Been Goh (Emeryville, California); Jorge Alonso-Gutierrez (San Francisco, California); Leonard Katz (Oakland, California); Jay D. Keasling (Berkeley, California) |
| ABSTRACT | This present invention provides a genetically modified host cell, such as an E. coli host cell, capable of producing or overproducing a hydroxylated methyl ketone (HMK), such as an omega-hydroxy and/or omega-1-hydroxy methyl ketone. |
| FILED | Thursday, July 22, 2021 |
| APPL NO | 17/383352 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/52 (20130101) Original (OR) Class C12N 2510/02 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025502 | Durham et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Jessica L. Durham (Frankfort, Illinois); Joseph A. Libera (Clarendon Hills, Illinois); Albert L. Lipson (Forest Park, Illinois); Yujia Liang (Lisle, Illinois) |
| ABSTRACT | A dry process for coating Ni-rich cathode powder with cubic LLZO powder prepared by flame spray pyrolysis. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 16/938037 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 4/11 (20160101) Original (OR) Class C23C 4/129 (20160101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/0402 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220025537 — THREE-DIMENSIONAL ELECTROCHEMICAL MANUFACTURING AND SENSING SYSTEM AND RELATED METHODS
| US 20220025537 | Jiang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junhua Jiang (Idaho Falls, Idaho); Robert D. Mariani (Idaho Falls, Idaho) |
| ABSTRACT | An electrochemical system includes at least one electrochemical cell with a receptacle containing an electrolytic bath in which is disposed a counter electrode. At least one nozzle opens from the receptacle toward and proximate a substrate configured as a working electrode. The at least one electrochemical cell is selectively configurable between a configuration for electrodeposition of a material onto the substrate and a configuration for electrodissolution of material from a structure on the substrate. In a method of using an electrochemical cell, a metal salt—of the electrolytic bath—is flowed through the nozzle in the presence of at least one of a voltage difference and a current flow between the working electrode and the counter electrode. The system may be configured for relative movement between the at least one nozzle and the substrate, and the electrochemical cell(s) may be usable for any of electrodeposition, electrodissolution, and electrochemical sensing. |
| FILED | Tuesday, December 10, 2019 |
| APPL NO | 17/309577 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 1/003 (20130101) Original (OR) Class C25D 3/665 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026332 | Hering et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| ASSIGNEE(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| INVENTOR(S) | Susanne Vera Hering (Berkeley, California); Gregory Stephen Lewis (Berkeley, California); Steven Russel Spielman (Oakland, California) |
| ABSTRACT | A method and apparatus to create water vapor supersaturation and particulate counts from an air sample. The method and apparatus include introducing an air sample into a chamber by passing a flow into the chamber through the inlet by pumping at the outlet. The method further includes closing the inlet while continuing the pumping to exhaust the air sample from the chamber through the outlet. The pumping is performed at a rate operable to reduce pressure inside the chamber such that the air sample in the central portion of the chamber cools, and water vapor from walls of the chamber has time to diffuse into the air sample in the chamber from the walls. The cycles are repeated by continuously repeating the introducing and closing. The walls of the chamber may be wet or dry. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/492955 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/065 (20130101) Original (OR) Class G01N 2015/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026333 | Hering et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| ASSIGNEE(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| INVENTOR(S) | Susanne Vera Hering (Berkeley, California); Gregory Stephen Lewis (Berkeley, California); Steven Russel Spielman (Oakland, California) |
| ABSTRACT | A method and apparatus to create water vapor supersaturation and particulate counts from an air sample. The method and apparatus include introducing an air sample into a chamber by passing a flow into the chamber through the inlet by pumping at the outlet. The method further includes closing the inlet while continuing the pumping to exhaust the air sample from the chamber through the outlet. The pumping is performed at a rate operable to reduce pressure inside the chamber such that the air sample in the central portion of the chamber cools, and water vapor from walls of the chamber has time to diffuse into the air sample in the chamber from the walls. The cycles are repeated by continuously repeating the introducing and closing. The walls of the chamber may be wet or dry. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494449 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026649 | VALLANCE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CUDOQUANTA FLORIDA, INC. (SARASOTA, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Ryan VALLANCE (Newbury Park, California); Shuhe LI (Pasadena, California); Rand D. DANNENBERG (Newbury Park, California); Michael K. BARNOSKI (Pacific Palisades, California) |
| ABSTRACT | To couple light between an optical fiber and a grating coupler of a photonic integrated circuits, a mirror is provided to turn light to/from the optical fiber to allow the axis of the optical fiber to be oriented at small angles or parallel to the surface of the PIC, and lowered close to the surface of the PIC. The mirror is further configured to reshape light from a flat polished optical fiber to produce a mode field resembling the mode field of an angled polished optical fiber, to match the design angle of existing grating couplers that are designed to work with angled polished optical fibers. The mirror and optical fiber alignment structure in the optical connector are integrally/simultaneous formed by precision stamping. |
| FILED | Tuesday, March 16, 2021 |
| APPL NO | 17/203565 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/14 (20130101) G02B 6/32 (20130101) G02B 6/34 (20130101) G02B 6/124 (20130101) G02B 6/305 (20130101) G02B 6/3838 (20130101) G02B 6/4214 (20130101) Original (OR) Class G02B 6/4248 (20130101) G02B 6/4249 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49 (20150115) Y10T 29/49119 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220027712 | Aimone |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Bradley Aimone (Keller, Texas) |
| ABSTRACT | A programmable logic unit is provided. The logic unit comprises a number of crossbar arrays. A control circuit connected to the crossbar arrays is configured to provide inputs to a specified subset of crossbar arrays according to a program. A layer of spiking neurons is connected to the crossbar arrays, wherein respective outputs from the crossbar arrays are summed together and input into the spiking neurons. A temporal buffer circuit is configured to hold spiking activation signals from the spiking neurons for a delay time specified by the program before routing the spiking activation signals back to the crossbar arrays as input through the control circuit. |
| FILED | Monday, July 27, 2020 |
| APPL NO | 16/939372 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) Original (OR) Class Static Stores G11C 11/54 (20130101) G11C 13/004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220027731 | YILMAZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Alper YILMAZ (Lewis Center, Ohio); Nima AJAM GARD (Dublin, Ohio); Ji Hyun LEE (Columbus, Ohio); Tunc ALDEMIR (Columbus, Ohio); Richard DENNING (Columbus, Ohio) |
| ABSTRACT | Systems and methods are described herein for real-time data processing and for emergency planning. Scenario test data may be collected in real-time based on monitoring local or regional data to ascertain any anomaly phenomenon that may indicate an imminent danger or of concern. A computer-implemented method may include filtering a plurality of different test scenarios to identify a sub-set of test scenarios from the plurality of different test scenarios that may have similar behavior characteristics. A sub-set of test scenarios is provided to a trained neural network to identify one or more sub-set of test scenarios. The one or more identified sub-set of test scenarios may correspond to one or more anomaly test scenarios from the sub-set of test scenarios that is most likely to lead to an undesirable outcome. The neural network may be one of: a conventional neural network and a modular neural network. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/371940 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/3495 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029038 | HARLEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SunPower Corporation (San Jose, California) |
| ASSIGNEE(S) | SunPower Corporation (San Jose, California) |
| INVENTOR(S) | Gabriel HARLEY (Mountain View, California); David D. SMITH (Campbell, California); Peter John COUSINS (Menlo Park, California) |
| ABSTRACT | The formation of solar cell contacts using a laser is described. A method of fabricating a back-contact solar cell includes forming a poly-crystalline material layer above a single-crystalline substrate. The method also includes forming a dielectric material stack above the poly-crystalline material layer. The method also includes forming, by laser ablation, a plurality of contacts holes in the dielectric material stack, each of the contact holes exposing a portion of the poly-crystalline material layer; and forming conductive contacts in the plurality of contact holes. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/498979 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/186 (20130101) H01L 31/0516 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029114 | Ke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weijun Ke (Evanston, Illinois); Konstantinos Stoumpos (Chicago, Illinois); Ioannis Spanopoulos (Evanston, Illinois); Mercouri G. Kanatzidis (Wilmette, Illinois) |
| ABSTRACT | Photoactive materials comprising organic-inorganic hybrid halide perovskite compounds are provided. Photovoltaic cells and light-emitting devices incorporating the photoactive materials into their light-absorbing and light-emitting layers, respectively, are also provided. The halide perovskites have an amAMX3 perovskite crystal structure, wherein am is an alkyl diamine cation, an aromatic diamine cation, an aromatic azole cation, a cyclic alkyl diamine cation or a hydrazinediium cation; A is a monovalent alkylammonium cation or an alkali metal cation; X is a halide ion or a combination of halide ions; and M is an octahedrally coordinated bivalent metal atom. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495121 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/24 (20130101) C07F 7/2284 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/44 (20130101) H01L 51/4213 (20130101) Original (OR) Class H01L 2251/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029146 | Cui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yi Cui (Stanford, California); Zheng Liang (Stanford, California); Yayuan Liu (Stanford, California); Dingchang Lin (Stanford, California) |
| ABSTRACT | A lithium battery includes a cathode, a composite lithium metal anode, and an electrolyte in contact with the cathode and the composite lithium metal anode. The composite lithium metal anode includes a porous matrix and lithium metal disposed within the porous matrix. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498119 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/382 (20130101) H01M 4/0402 (20130101) H01M 4/0483 (20130101) Original (OR) Class H01M 4/663 (20130101) H01M 4/1395 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029149 | CROY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason R. CROY (Plainfield, Illinois); Mahalingam BALASUBRAMANIAN (Naperville, Illinois) |
| ABSTRACT | Stabilized layered lithium metal oxide cathode materials are described which include excess lithium, Ni, Mn, and at least one other metal ion. The materials comprise a layered LiMO2-type material in which M comprises a combination of Ni, Mn, and at least one other metal ion that includes less than about 6 mol % Co; and which has about 1 to 6 percent excess lithium. In one embodiment, the stabilized lithium metal oxide cathode material comprises a composition having the empirical formula xLi2MnO3.(1−x)LiNi0.5+δ/2Mn0.5−δCoδ/2O2, wherein 0<x≤0.1; and 0≤δ≤0.2. In another embodiment, the stabilized lithium metal oxide cathode material comprises a composition having the empirical formula Li1+3y[NiaMnbM′c]1−yO2, wherein M′ is one of more metal selected from the group consisting of Co, Al, Fe, Mg, and Ti; 0<y≤0.02; 0.85≤a≤0.96; 0.03≤b≤0.1; and 0.01≤c≤0.1. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 16/937806 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/134 (20130101) Original (OR) Class H01M 4/366 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029156 | THACKERAY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Michael M. THACKERAY (Naperville, Illinois); Eungje LEE (Naperville, Illinois); Jason R, CROY (Plainfield, Illinois); Boyu SHI (Willowbrook, Illinois); Jihyeon GIM (Naperville, Illinois) |
| ABSTRACT | Cobalt-free lithium-manganese-nickel-oxide electrode materials for lithium cells and batteries, notably rechargeable Li-ion batteries, are described herein. These electrode materials have a lithiated-spinel structure with the general formula LiMnxNiyMzO2, or alternatively in lithiated-spinel notation, Li2Mn2xNi2yM2zO4, in which x+y+z=1, 0<x<1.0, 0<y<1.0, 0≤z≤0.5, and in which M is selected from one or more metal cations other than Mn, Ni and Co. In general, the Mn:Ni ratio in the lithiated-spinel structures described herein is less than 2:1 and greater than 1:2, preferably close to 1:1, and more preferably 1:1. Optionally, the cobalt-free lithiated spinel materials can be blended or structurally-integrated with other cathode materials that may include cobalt. |
| FILED | Tuesday, December 29, 2020 |
| APPL NO | 17/136234 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/58 (20130101) H01M 4/366 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 4/623 (20130101) H01M 4/663 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029160 | THACKERAY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Michael M. THACKERAY (Naperville, Illinois); Eungje LEE (Naperville, Illinois); Jason R, CROY (Plainfield, Illinois); Boyu SHI (Willowbrook, Illinois); Jihyeon GIM (Naperville, Illinois) |
| ABSTRACT | Lithium-manganese-nickel-oxide electrode materials for lithium cells and batteries, notably rechargeable Li-ion batteries, are described herein. These electrode materials are comprised of crystalline, structurally-integrated, lithium-metal-oxides of empirical formula LiM1O2 wherein M1 comprises a combination of Mn and Ni transition metal ions; the crystal structure of the materials comprises domains of a disordered lithiated-spinel component, a disordered layered component, and a disordered rock salt component, in which the oxygen lattice of the components is cubic-close packed. In general, the Mn:Ni ratio in the lithiated-spinel structures described herein is less than 2:1 and preferably close to 1:1, and more preferably 1:1. Optionally, the lithium-manganese-nickel-oxide electrode materials can be blended or structurally-integrated with other cathode materials and structures. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313752 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 4/623 (20130101) H01M 4/663 (20130101) H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029161 | THACKERAY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Michael M. THACKERAY (Naperville, Illinois); Eungje LEE (Naperville, Illinois); Jason R, CROY (Plainfield, Illinois); Joseph A. LIBERA (Clarendon Hills, Illinois); Kyojin KU (Daejeon, South Korea) |
| ABSTRACT | Lithium-manganese-nickel-oxide electrode materials are described herein, which are crystalline, structurally-integrated, lithium-metal-oxides of empirical formula LiM1O2 wherein M1 comprises a combination of Mn and Ni transition metal ions; the crystal structure of the materials comprises domains of a disordered lithiated-spinel component, a disordered layered component, and optionally a disordered rock salt component, in which the oxygen lattice of the components is cubic-close packed. In general, the Mn:Ni ratio in the lithiated-spinel structures described herein is less than 2:1 and preferably close to 1:1. Preferably, M1 is M2(1-w)M3w, wherein M2 is a combination of Mn and Ni transition metal ions in a ratio of Mn to Ni ions of about 2:1 to about 1:1; M3 is one or more metal cations selected from the group consisting of an Al cation, a Ga cation, a Mg cation, a Ti cation; and a Co cation; and 0<w≤0.5. |
| FILED | Friday, June 18, 2021 |
| APPL NO | 17/351944 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) Original (OR) Class H01M 4/623 (20130101) H01M 4/663 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029362 | Shen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zheng Shen (Chicago, Illinois); Zhixi Deng (Chicago, Illinois); Yuanfeng Zhou (Chicago, Illinois) |
| ASSIGNEE(S) | ILLINOIS INSTITUTE OF TECHNOLOGY (CHICAGO, Illinois) |
| INVENTOR(S) | Zheng Shen (Chicago, Illinois); Zhixi Deng (Chicago, Illinois); Yuanfeng Zhou (Chicago, Illinois) |
| ABSTRACT | A wireless-controlled smart plug device and methods of use and operation, using a solid state switch to provide electrical power from an outlet to a load, and provide protection against overload, short circuit, ground, arc, or voltage surge faults. The switch includes a bidirectional semiconductor switch with two back-to-back connected transistors, such as silicon power MOSFETs, silicon insulated-gate bipolar transistors (IGBTs), silicon carbide (SiC) transistors, or gallium nitride (GaN) transistors, each configured to control the current flow from the electrical receptacle to the external electrical load. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/386051 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/6666 (20130101) H01R 13/6683 (20130101) H01R 13/7038 (20130101) Original (OR) Class H01R 13/7135 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029549 | Ravi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lakshmi Ravi (Blacksburg, Virginia); Joshua Stewart (Blacksburg, Virginia); Dong Dong (Blacksburg, Virginia); Rolando Burgos (Blacksburg, Virginia) |
| ABSTRACT | An inverter with a modular bus assembly is described. In various embodiments, the modular bus assembly includes a laminated motherboard and a plurality of capacitor daughtercards. The laminated motherboard can be configured to interface a plurality of phase-leg modules and a plurality of capacitor daughtercards through a plurality of terminals and connectors located on a bottom side or a top side of the laminated motherboard. The laminated motherboard includes a layer stack with a plurality of conductor layers. Each of the plurality of conductor layers is implemented with a net spacing from a neighboring plated through hole (PTH) based at least in part on differences in potential to be applied to each of the plurality of conductor layers as compared to a potential to be applied to the PTH. Embedded shield polygons can be implemented on the laminated motherboard to mitigate surface discharge at surface terminal (PTH/SMT) triple junctions. |
| FILED | Monday, July 27, 2020 |
| APPL NO | 16/939914 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/003 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/116 (20130101) H05K 1/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220022765 | Chon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ki H. Chon (Mansfield, Connecticut); Dong Han (Tolland, Connecticut); Syed Khairul Bashar (Mansfield Center, Connecticut); Fahimeh Mohagheghian (Storrs, Connecticut) |
| ABSTRACT | The present disclosure relates to techniques for the estimating anomalies within photoplethysmographic signals. The techniques may include use of instruments that include photoplethysmographic and acceleration sensors. Time-frequency spectra may be used to determine the anomalies. Corrupted signals may be detected and corrected through applications of machine learning and feature extraction. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/364684 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/341 (20210101) A61B 5/02416 (20130101) Original (OR) Class A61B 5/4836 (20130101) A61B 5/7264 (20130101) A61B 2562/0219 (20130101) Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023227 | Khan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Southern University Research and Service Foundation, Inc. (Statesboro, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mujibur Rahman Khan (Martinez, Georgia); Md Mahmudul Hasan (Urbana, Illinois); Ali S. Arbab (Martinez, Georgia); Mohammad Harun Rashid (Augusta, Georgia) |
| ABSTRACT | Disclosed herein are nano-encapsulated compositions and systems and methods of preparing the same. The compositions may be obtained through co-axial electrospraying with pulsating voltage. The nano-encapsulated composition exhibit improved pharmacokinetic properties. Various embodiments include systems and methods that apply a constant voltage and/or a pulsating voltage at a frequency to a plate having co-axial outlets through which a core solution and capsule solution flow. In some implementations, the pulsating voltage fluctuates between a minimum pulsating voltage and a maximum pulsating voltage, wherein the minimum pulsating voltage is 0 KV or greater and the maximum pulsating voltage is greater than 0 KV and the minimum pulsating voltage. The constant voltage is greater than 0 KV, and a total maximum applied voltage to the plate is the sum of the maximum pulsating voltage and the constant voltage. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/328708 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5192 (20130101) Original (OR) Class A61K 31/337 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/04 (20130101) Spraying Apparatus; Atomising Apparatus; Nozzles B05B 5/0255 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023484 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania); BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian Yang (State College, Pennsylvania); Kytai T. Nguyen (Grand Prairie, Texas); Zhiwei Xie (State College, Pennsylvania) |
| ABSTRACT | In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499221 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 15/26 (20130101) A61L 15/44 (20130101) A61L 15/64 (20130101) A61L 15/225 (20130101) Original (OR) Class A61L 15/425 (20130101) A61L 2300/252 (20130101) A61L 2300/404 (20130101) A61L 2300/414 (20130101) A61L 2300/604 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220023996 | Kavanaugh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jack Kavanaugh (Los Angeles, California); Richard B. Kaner (Pacific Pallsades, California); Chris Turner (Lancaster, California); Georgly Alkopov (Greenwood, South Carolina) |
| ABSTRACT | Disclosed herein, in certain embodiments, are composite materials, methods, tools and abrasive materials comprising a tungsten-based metal composition and an alloy. In some cases, the composite materials or material are resistant to oxidation. |
| FILED | Tuesday, May 04, 2021 |
| APPL NO | 17/307600 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/105 (20130101) Tools for Grinding, Buffing, or Sharpening B24D 3/06 (20130101) Original (OR) Class B24D 18/0009 (20130101) Alloys C22C 9/06 (20130101) C22C 29/14 (20130101) C22C 30/02 (20130101) C22C 32/0073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024583 | Barawkar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shraddha Barawkar (Cincinnati, Ohio); Manish Kumar (Cincinnati, Ohio); Kelly Cohen (Mason, Ohio) |
| ABSTRACT | Systems, methods, and computer program products for controlling a drone using a tether. A drone is coupled to a distal end of the tether, and a force sensor measures one or more force parameters exerted on the drone by the tether. The force parameters are in turn used to generate control parameters, and the control parameters provided to a flight controller. The flight controller generates one or more propulsion parameters based on the control parameters, and provides the propulsion parameters to respective propulsion units of the drone. The drone can thereby be controlled by manipulating a proximate end of the tether, which changes the force parameters measured by the force sensor. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/385026 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/022 (20130101) B64C 39/024 (20130101) Original (OR) Class B64C 2201/141 (20130101) B64C 2201/148 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 3/02 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0808 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024768 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wenzhi Li (Miami, Florida); Arun Thapa (Miami, Florida) |
| ASSIGNEE(S) | The Florida International University Board of Trustees (Miami, Florida) |
| INVENTOR(S) | Wenzhi Li (Miami, Florida); Arun Thapa (Miami, Florida) |
| ABSTRACT | Copper-filled carbon nanotubes and methods of synthesizing the same are provided. Plasma-enhanced chemical vapor deposition can be used to synthesize vertically aligned carbon nanotubes filled with copper nanowires. The copper filling can occur concurrently with the carbon nanotube growth, and the carbon nanotubes can be completely filled by copper. The filling of Cu inside the CNTs can be controlled by tuning the synthesis temperature. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/201464 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/16 (20170801) Original (OR) Class C01B 32/178 (20170801) C01B 2202/08 (20130101) C01B 2202/10 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2002/85 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) C23C 16/50 (20130101) C23C 16/0227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024954 | ZHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Board of Trustees of Northern Illinois University (DeKalb, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kai ZHU (Littleton, Colorado); Tao XU (Naperville, Illinois) |
| ABSTRACT | The present disclosure relates to a composition that includes a sequestering material capable of binding a target material, where the sequestering material includes a first component that includes at least one of a functional group, a molecule, an oligomer, or a polymer, and the target material includes at least one of an element, a chemical, and/or a compound. In some embodiments of the present disclosure, the element may include at least one element from at least one of Rows 4, 5, 6, and 7 of the Periodic Table and/or an inner transition metal. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498268 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/3873 (20130101) C07F 9/4006 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 71/02 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/042 (20130101) Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 40/38 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025173 | Chu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Qianli Chu (Grand Forks, North Dakota); Rahul Shahni (Grand Forks, North Dakota) |
| ASSIGNEE(S) | The University of North Dakota (Grand Forks, North Dakota) |
| INVENTOR(S) | Qianli Chu (Grand Forks, North Dakota); Rahul Shahni (Grand Forks, North Dakota) |
| ABSTRACT | A polymer includes a plurality of repeated polymerized units according to scheme (2): |
| FILED | Tuesday, August 25, 2020 |
| APPL NO | 17/001966 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/193 (20130101) C08G 63/199 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/22 (20130101) C08K 5/57 (20130101) Compositions of Macromolecular Compounds C08L 67/02 (20130101) Original (OR) Class C08L 2203/10 (20130101) C08L 2203/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025356 | BAKER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David BAKER (Seattle, Washington); David YOUNGER (Seattle, Washington); Eric KLAVINS (Seattle, Washington) |
| ABSTRACT | The present invention relates to methods and compositions for the high throughput screening of protein-protein interactions in yeast liquid culture. Protein fusions non-native to yeast may be expressed to replace endogenous sexual agglutination proteins and mediate library-by-library interrogation of protein interactions. The methods and compositions of the invention can be utilized for the characterization of protein interaction networks in high throughput for both binding affinity and specificity, which is crucial for understanding cellular functions, screening therapeutic candidates, and evaluating engineered protein networks. |
| FILED | Monday, September 20, 2021 |
| APPL NO | 17/480078 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1055 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025373 | LaBean et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thom LaBean (Raleigh, North Carolina); Abhichart Krissanaprasit (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure provides compositions and methods related to nucleic acid molecules having therapeutic aptamers. In particular, the present disclosure provides nucleic acids molecules comprising one or more aptamers having anticoagulant activity, as well as corresponding nucleic acid antidotes, for the modulation of blood coagulation in the context of disease and surgical intervention. |
| FILED | Friday, October 25, 2019 |
| APPL NO | 17/285371 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2310/322 (20130101) C12N 2310/531 (20130101) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025381 | WONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts) |
| INVENTOR(S) | Wilson Wai Chun WONG (Brookline, Massachusetts); Yage DING (Allston, Massachusetts) |
| ABSTRACT | The technology described herein is directed to inducible and repressible polypeptides and polypeptide systems. In particular, described herein are split sequence-specific nucleases and split recombinases that are linked to drug-inducible or drug-repressible dimerization domains. In some embodiments, the polypeptides comprise sequestering domains and/or have their expression controlled by an inducible promoter. In multiple aspects described herein are polynucleotides, vectors, cells, and pharmaceutical compositions comprising said polypeptides or polypeptide systems. Also described herein are methods of using said polypeptide systems to modulate the expression of a target polypeptide or to treat a subject in need of a cell therapy. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381780 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/1241 (20130101) C12N 15/63 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025385 | Wu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fuqing Wu (Tempe, Arizona); Samat Bayakhmetov (Tempe, Arizona); Changhan He (Tempe, Arizona); Qi Zhang (Tempe, Arizona); Xingwen Chen (Tempe, Arizona); Yang Kuang (Tempe, Arizona); Xiao Wang (Chandler, Arizona) |
| ASSIGNEE(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| INVENTOR(S) | Fuqing Wu (Tempe, Arizona); Samat Bayakhmetov (Tempe, Arizona); Changhan He (Tempe, Arizona); Qi Zhang (Tempe, Arizona); Xingwen Chen (Tempe, Arizona); Yang Kuang (Tempe, Arizona); Xiao Wang (Chandler, Arizona) |
| ABSTRACT | Synthetic gene circuits and methods for modeling complex spatial patterns (for example, in somitogenesis) and related plasmids are disclosed herein. Also disclosed herein are methods of generating an expression pattern using the synthetic gene circuit described herein. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/382305 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/72 (20130101) Original (OR) Class C12N 2800/101 (20130101) C12N 2830/002 (20130101) C12N 2830/003 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025425 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Haitian Zhang (Lafayette, Indiana); Fan Zuo (Terre Haute, Indiana); Feiran Li (West Lafayette, Indiana); Jong Hyun Choi (West Lafayette, Indiana); Shriram Ramanathan (West Lafayette, Indiana) |
| ABSTRACT | Disclosed herein is an ultralow concentration sensor of biomarkers, and the use thereof to help heath industry, medical centers and food industry to sense biomarkers by catalyst assisted charge transfer from the biomarkers to the sensor device, resulting increased electrical resistance of the sensor. Specifically, perovskite nickelate RNiO3 is used to sense biological material facilitated by specific enzymatic activity in the proximity. |
| FILED | Tuesday, December 10, 2019 |
| APPL NO | 17/311707 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1486 (20130101) A61B 5/14532 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/005 (20130101) Original (OR) Class C12Q 1/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025428 | Hughes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boise State University (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William Hughes (Boise, Idaho); Elton Graugnard (Boise, Idaho); Wan Kuang (Meridian, Idaho); Timothy Andersen (Boise, Idaho); Eric Hayden (Boise, Idaho); Reza Zadegan (Greensboro, North Carolina); George Dickinson (Boise, Idaho); Luca Piantanida (Boise, Idaho); William Clay (Boise, Idaho); Christopher Green (Alexandria, Virginia); Golam Mortuza (Boise, Idaho) |
| ABSTRACT | Compositions and methods for encoding and retrieving data into nucleic acid memory for storage. More specifically, data is encoded into spatial locations within a nucleic acid architecture, which allows the data to be retrieved using super resolution microscopy. The data is then interrogated for errors, the errors corrected, and the data is then decoded. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/443312 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/123 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026340 | Di Carlo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Dino Di Carlo (Los Angeles, California); Daniel R. Gossett (Los Angeles, California); Henry T.K. Tse (San Francisco, California) |
| ABSTRACT | A system is disclosed that enables the automated measurement of cellular mechanical parameters at high throughputs. The microfluidic device uses intersecting flows to create an extensional flow region where the cells undergo controlled stretching. Cells are focused into streamlines prior to entering the extensional flow region. In the extensional region, each cell's deformation is measured with an imaging device. Automated image analysis extracts a range of independent biomechanical parameters from the images. These may include cell size, deformability, and circularity. The single cell data that is obtained may then be used to in a variety of ways. Scatter density plots of deformability and circularity may be developed and displayed for the user. Mechanical parameters such as deformability and circularity may be gated or thresholded to identify certain cells of interest or sub-populations of interest. Similarly, the mechanical data obtained using the device may be used as cell signatures. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496758 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502715 (20130101) B01L 3/502776 (20130101) B01L 2200/0605 (20130101) B01L 2200/0647 (20130101) B01L 2200/0652 (20130101) B01L 2300/0654 (20130101) B01L 2300/0864 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) G01N 15/1459 (20130101) G01N 15/1463 (20130101) Original (OR) Class G01N 15/1484 (20130101) G01N 33/487 (20130101) G01N 33/574 (20130101) G01N 2015/0065 (20130101) G01N 2015/1495 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 99/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026704 | SHIAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SOLCHROMA TECHNOLOGIES, INC. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel SHIAN (Arlington, Massachusetts); Roger DIEBOLD (Somerville, Massachusetts) |
| ABSTRACT | Display devices and actuators and other components for a display device are provided. Display devices are provided configured to alter an optical property by moving an amount of a first fluid through which light can pass. In some aspects, the first fluid is movable within a cavity by varying an amount of pressure on the cavity; and the display includes a means of varying the amount of pressure. The means can include an actuator. An actuator is provided that has a first cavity containing fluid and bounded at least in part by a first elastomer; a second cavity containing fluid and bounded at least in by part by a second elastomer; a channel connecting the first cavity to the second cavity; and a valve configured to be electrically operated into an open state or a closed state and thereby allow or block flow of the fluid through the channel. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/396479 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 26/004 (20130101) Original (OR) Class Arrangements or Circuits for Control of Indicating Devices Using Static Means to Present Variable Information G09G 3/344 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220028497 | Keung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | North Carolina State University (Raleigh, North Carolina) |
| INVENTOR(S) | Albert Jun Qi Keung (Cary, North Carolina); James M. Tuck, III (Raleigh, North Carolina); Kevin Volkel (Raleigh, North Carolina); Kyle Tomek (Raleigh, North Carolina); Kevin Lin (Raleigh, North Carolina) |
| ABSTRACT | Processes and systems for non-destructively storing, accessing, and editing information using nucleic acids are disclosed. Representative processes include a process for extracting a data file from a database, wherein the data file comprises information encoded into one or more polynucleotide strands and wherein the database comprises a plurality of polynucleotide strands; a process for expanding a number of unique data files in a database that can be addressed with a predetermined number of oligonucleotide primers, wherein the unique data files each comprise information encoded into one or more polynucleotide strands and wherein the database comprises a plurality of polynucleotide strands; a process for differentially reading information encoded into one or more polynucleotide strands; a process for manipulating files while in storage; and a process for extracting a data file from a database, wherein the data file comprises information encoded into a polynucleotide strand. Systems for carrying out the processes are also disclosed. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 17/291517 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/10 (20190201) G16B 25/20 (20190201) G16B 50/30 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220028572 | Ndukaife |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justus C. Ndukaife (Nashville, Tennessee) |
| ABSTRACT | A nanotweezer and method of trapping and dynamic manipulation thereby are provided. The nanotweezer comprises a first metastructure including a first substrate, a first electrode, and a plurality of plasmonic nanostructures arranged in an array, and a trapping region laterally displaced from the array; a second metastructure including a second substrate and a second electrode; a microfluidic channel between the first metastructure and the second metastructure; a voltage source configured to selectively apply an electric field between the first electrode and the second electrode; and a light source configured to selectively apply an excitation light to the microfluidic channel at a first location corresponding to the array, thereby to trap a nanoparticle at a second location corresponding to the trapping region. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/443682 |
| CURRENT CPC | Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029173 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huixin He (New Brunswick, New Jersey); Qingdong Li (New Brunswick, New Jersey); Jenny Lockard (New Brunswick, New Jersey) |
| ABSTRACT | Provided herein are single atom catalysts embedded in carbon nanomaterials and microwave assisted methods of preparing the same. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381811 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/9008 (20130101) Original (OR) Class H01M 4/9083 (20130101) H01M 2004/8689 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029677 | Sur et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Sanjib Sur (Cayce, South Carolina); Moh. S. Saadat (West Columbia, South Carolina); Srihari Nelakuditi (Columbia, South Carolina) |
| ABSTRACT | Described herein are systems, methods and devices for implementing a temperature-aware, multi-antenna scheduler that cools mmWave devices by preventing heat buildup via switching or distributing a data stream to other redundant antennas, allowing for dissipation of heat as well as providing reliable connectivity. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/327881 |
| CURRENT CPC | Transmission H04B 7/0608 (20130101) Original (OR) Class H04B 7/0693 (20130101) Wireless Communication Networks H04W 52/0277 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029897 | Han et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Han (Bridgewater, New Jersey); Vijay Gopalakrishnan (Edison, New Jersey); Muhammad Bilal Anwer (Branchburg, New Jersey); Zhi-Li Zhang (Eden Prairie, Minnesota); Yang Zhang (Saint Paul, Minnesota) |
| ABSTRACT | Systems, computer-readable media, and methods are disclosed for parallel data processing for service function chains with network functions spanning multiple servers. An example system includes a first server hosting a first network function of a service function chain, a second server hosting a second network function of the service function chain, a mirror function deployed in a first switch to replicate a plurality of packets received by the system and to send respective copies of the plurality of packets to the first network function and to at least one of the second network function and a third network function of the service function chain, and a merge function deployed in a second switch to merge respective outputs of the first network function and the at least one of the second network function and the third network function. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498440 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/5054 (20130101) Original (OR) Class H04L 47/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220030080 | Parra et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IPPM Venture, LLC (Brooklyn, New York) |
| ASSIGNEE(S) | IPPM Venture, LLC (Brooklyn, New York) |
| INVENTOR(S) | Lucas C. Parra (Brooklyn, New York); Jens Madsen (New York, New York) |
| ABSTRACT | A method to assess a human subject's attention while experiencing dynamic media. An attention-predictive response (e.g. time course of gaze position, or pupil size, or heart-rate, etc.) is monitored while the subject watches the media. Similarity of the time course of this response to the time course of a predicted response provides a quantitative measure of the subject's attention to the media |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/450415 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/013 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220022388 | Gurau et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Southern University Research and Service Foundation, Inc. (Statesboro, Georgia); B and L Naval Stores Inc. (Hinesville, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Gurau (Statesboro, Georgia); Lloyd Busby (Hinesville, Georgia) |
| ABSTRACT | Provided are robotic systems and methods for identifying a particular type of tree or plant (e.g., slash pine trees), for tapping them and collect their oleoresin for processing using an autonomous, long-range robotic forest rover. One aspect of the system comprises an autonomous vehicle equipped with an industrial robot, automated tool changer, a plurality of tools required for robotic operations, vision and navigation systems and powertrain for long-range operation. The rover identifies healthy, mature trees or plants, approaches them and performs the robotic operations required for tapping the trees or plants. In addition to these tasks, the Global Navigation Satellite System (GNSS) coordinates of the tree or plant is recorded along with its diameter, and a digital image of the tree or plant. This information is communicated to a base station for creating and updating a tree farm database. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331124 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 23/14 (20130101) Original (OR) Class Manipulators; Chambers Provided With Manipulation Devices B25J 5/00 (20130101) B25J 9/1679 (20130101) B25J 9/1697 (20130101) B25J 15/04 (20130101) Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/60 (20190201) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 2219/40298 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0214 (20130101) G05D 1/0231 (20130101) G05D 1/0278 (20130101) G05D 2201/0201 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220022430 | Wagoner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of North Carolina at Greensboro (Greensboro, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kaira Wagoner (Greensboro, North Carolina); Olav Rueppell (Greensboro, North Carolina) |
| ABSTRACT | The presently disclosed subject matter provides synergistic mixtures for inducing hygienic behavior in honey bees and related compositions and methods. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498741 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 51/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220022498 | RICHARDS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin); Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin); Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| INVENTOR(S) | Mark P. RICHARDS (Madison, Wisconsin); Mark HARGROVE (Ames, Iowa); Nantawat TATIYABORWORNTHAM (Bangkok, Thailand); Jie YIN (Madison, Wisconsin); Wenjing ZHANG (Madison, Wisconsin) |
| ABSTRACT | The disclosure provides for compositions and methods for the preservation of meat substitutes containing plant heme protein. In particular, small molecules that can fit in the unique heme pocket of plant heme proteins are provided to stabilize and preserve meat substitutes the products. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495336 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 3/227 (20130101) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 3/34 (20130101) Original (OR) Class A23L 3/3418 (20130101) A23L 3/3463 (20130101) A23L 19/00 (20160801) A23L 33/185 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025132 | Scher et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Herbert B. Scher (Moraga, California); Scott Strobel (Davis, California); Tina Jeoh Zicari (Davis, California); Dana Wong (Davis, California) |
| ABSTRACT | Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336766 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/14 (20130101) B01J 13/043 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) Original (OR) Class C08J 2305/04 (20130101) C08J 2305/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/16 (20130101) C08K 3/28 (20130101) C08K 5/095 (20130101) C08K 5/5357 (20130101) C08K 2003/162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220025360 | Raman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srivatsan Raman (Middleton, Wisconsin); Phil Huss (Madison, Wisconsin) |
| ABSTRACT | Described herein is a method of preparing an unbiased library of phage variants, comprising (a) preparing a population of “acceptor phage”; (b) removing an endogenous target gene and inserting gene variants into the acceptor phage genomes; (c) enriching the recombined phages; and (d) expressing the library for selection. The acceptor phage is a lytic phage comprising a synthetic genome wherein the target gene of interest is flanked by recombinase sites. The acceptor phage infects a first host bacteria expressing a recombination plasmid facilitating recombination. The phages then infect a second host bacteria expressing a counterselection system that accumulates recombined phage variants and selecting against non-recombined phages. The accumulated phage variants infect a third host bacteria. The phage library may then be sequenced and characterized. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/386176 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/102 (20130101) C12N 15/1093 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2795/10052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220023856 | Peyvan |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kianoosh Peyvan (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kianoosh Peyvan (Seattle, Washington) |
| ABSTRACT | A cell capture, disruption, and extraction method includes a introducing a plurality of abrasives in a disruption chamber, which can include diamond powder, variably and multi dimensionally disbursed therein, and a pestle positioned in the disruption chamber. The method includes agitating the abrasives by moving the disruption chamber and/or pestle, agitation of the abrasives tearing cell structure in the solution to access its contents. A binding column or size exclusion column can be positioned downstream of the disruption chamber. Cell solution can first be introduced in the disruption chamber, the abrasives capturing the cells and allowing therethrough and purging the waste content, then breaking the cell content. The lysate can then bind to an extraction matrix downstream of the disruption chamber or it can be mixed in with the abrasives. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 16/557137 |
| CURRENT CPC | Separation B01D 15/34 (20130101) B01D 24/007 (20130101) B01D 24/105 (20130101) B01D 2101/00 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2300/06 (20130101) B01L 2300/0832 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/286 (20130101) G01N 1/4077 (20130101) G01N 2001/2873 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024797 | Finger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Paragon Space Development Corporation (Tucson, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Barry Wynns Finger (Santa Fe, Texas); Laura Katrina Kelsey (Erie, Colorado); Chad E. Bower (Littleton, Colorado) |
| ABSTRACT | This disclosure provides an integrated system and method for producing purified water, hydrogen, and oxygen from contaminated water. The contaminated water may be derived from regolith-based resources on the moon, Mars, near-Earth asteroids, or other destination in outer space. The integrated system and method utilize a cold trap to receive the contaminated water in a vapor phase and selectively freeze out water from one or more volatiles. A heat source increases temperature in the cold trap to vaporize the frozen contaminated water to produce a gas stream of water vapor and volatiles. A chemical scrubber may remove one or more volatiles. The integrated system and method utilize ionomer membrane technology to separate the water vapor from remaining volatiles. The water vapor is delivered for crew use or delivered to an electrolyzer to produce hydrogen and oxygen. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495424 |
| CURRENT CPC | Separation B01D 5/006 (20130101) B01D 8/00 (20130101) B01D 19/0031 (20130101) B01D 53/58 (20130101) B01D 53/229 (20130101) B01D 71/00 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/02 (20130101) C02F 1/22 (20130101) C02F 1/447 (20130101) C02F 1/448 (20130101) C02F 9/00 (20130101) Original (OR) Class C02F 2101/101 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220028907 | KAPADIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (LOS ANGELES, California) |
| ASSIGNEE(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (LOS ANGELES, California); CALIFORNIIA INSTITUTE OF TECHNOLOGY (PASADENA, California); InPi, LLC (LOS ANGELES, California) |
| INVENTOR(S) | Rehan Rashid KAPADIA (Los Angeles, California); Khaled AHMED (San Jose, California); Frank GREER (Pasadena, California) |
| ABSTRACT | A method for forming a composite substrate containing layers of dissimilar materials is provided. The method includes a step of disposing a release layer over a base substrate where the base substrate is composed of a first material. A template layer is attached to the release layer. Characteristically, the template layer is composed of a second material and adapted to form a compound semiconductor device thereon. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/443380 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1469 (20130101) Original (OR) Class H01L 27/14634 (20130101) H01L 31/1852 (20130101) H01L 31/03046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220030031 | KOCSIS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jin KOCSIS (Lafayette, Indiana); Mututhanthrige Praveen Sameera FERNANDO (Akron, Ohio); Yifu WU (Akron, Ohio) |
| ASSIGNEE(S) | The University of Akron (Akron, Ohio) |
| INVENTOR(S) | Jin KOCSIS (Lafayette, Indiana); Mututhanthrige Praveen Sameera FERNANDO (Akron, Ohio); Yifu WU (Akron, Ohio) |
| ABSTRACT | In one or more embodiments, the present invention is directed to a blockchain secured, software-defined network and monitoring system comprising: a multi-controller software-defined network (SDN) network layer; a blockchain based security and autonomy layer; a deep learning-driven decision making layer comprising the one or more computational centers and a horizontal data plane layer. In some embodiments, the present invention is directed to methods for ensuring the integrity of a control commands and optimizing performance and security using the blockchain secured, software-defined network and monitoring system. In various embodiments, the present invention relates to methods for extracting useful features from said labelled and non-labelled data contained in the horizontal data plane layer in the blockchain secured, software-defined network and monitoring system using a knowledge domain-enabled hybrid semi-supervision learning method. |
| FILED | Tuesday, November 19, 2019 |
| APPL NO | 17/297270 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/64 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/3236 (20130101) H04L 9/3297 (20130101) H04L 41/20 (20130101) H04L 63/20 (20130101) Original (OR) Class H04L 2209/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220023859 | Hung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Combinati Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ju-Sung Hung (Palo Alto, California); Andrew Zayac (San Leandro, California); Megan Dueck (Brisbane, California) |
| ABSTRACT | In some aspects, the present disclose provides methods for amplifying and quantifying nucleic acids. Methods for amplifying and quantifying nucleic acids comprise isolating a sample comprising nucleic acid molecules into a plurality of microchambers, performing a polymerase chain reaction on the plurality of microchambers, and analyzing the results of the polymerase chain reaction. In some aspects, the present disclosure provides devices consistent with the methods herein. |
| FILED | Friday, February 12, 2021 |
| APPL NO | 17/175021 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 7/52 (20130101) B01L 2200/0605 (20130101) B01L 2300/18 (20130101) B01L 2300/0609 (20130101) B01L 2300/0851 (20130101) B01L 2300/0864 (20130101) B01L 2400/049 (20130101) B01L 2400/0487 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220024325 | Pettey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Response Technologies, LLC (Coventry, Rhode Island) |
| ASSIGNEE(S) | Response Technologies, LLC (Coventry, Rhode Island) |
| INVENTOR(S) | David Allen Pettey (Westport, Massachusetts); Edmund F. Bard (Cumberland, Rhode Island); Lao Vang (Providence, Rhode Island) |
| ABSTRACT | A fuel cell containing fuel for an aircraft includes an innermost layer configured to contact the fuel, an outermost layer and a containment gel formed from isocyanate and polyol interposed between the innermost and outermost layers. The containment gel is configured to self-seal a ballistically formed hole therein, thereby reducing leakage of the fuel from the fuel cell. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/228993 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 1/00 (20130101) B32B 5/02 (20130101) B32B 7/12 (20130101) B32B 27/12 (20130101) B32B 27/40 (20130101) B32B 2250/40 (20130101) B32B 2307/762 (20130101) B32B 2605/18 (20130101) Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/71 (20190201) B60L 50/72 (20190201) Original (OR) Class B60L 2200/10 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220026580 | Crouch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Amida Technology Solutions, Inc. (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfred Larry Crouch (Cedar Park, Texas); Peter Lawrence Levin (Silver Springs, Maryland); John David Akin (Plano, Texas); Adam Wade Ley (Allen, Texas); Matthew McKinnon Ritonia (Arlington, Virginia); Wesley Layton Ellington (Dallas, Texas); Maria Anne Spasojevic (Palo Alto, California) |
| ABSTRACT | A method and system for analysis of a facility may include providing an emulation host system, generating a pristine circuit model on the emulation host system, inserting a first hardware trojan model, emulating operation of the golden circuit model, and emulating operation of the first hardware trojan model, and determine a set of machine-learning models, detecting the presence of an unknown trojan as a function of the set of machine learning models and using the same to authenticate the integrity of a GPS signal. |
| FILED | Sunday, December 27, 2020 |
| APPL NO | 17/134441 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/23 (20130101) Original (OR) Class G01S 19/42 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220030013 | Crouch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Amida Technology Solutions, Inc. (Washinton, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfred Larry Crouch (Cedar Park, Texas); Peter Lawrence Levin (Silver Springs, Maryland); John David Akin (Plano, Texas); Adam Wade Ley (Allen, Texas); Matthew McKinnon Ritonia (Arlington, Virginia); Wesley Layton Ellington (Dallas, Texas); Maria Anne Spasojevic (Palo Alto, California) |
| ABSTRACT | A method and system for analysis of a facility may include providing an emulation host system, generating a pristine circuit model on the emulation host system, inserting a first hardware trojan model, emulating operation of the golden circuit model, and emulating operation of the first hardware trojan model, and determine a set of machine-learning models, detecting the presence of an unknown trojan as a function of the set of machine learning models. |
| FILED | Sunday, December 27, 2020 |
| APPL NO | 17/134438 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2379 (20190101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/00 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220029839 | Flajslik et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mario Flajslik (Hopkinton, Massachusetts); Eric R. Borch (Fort Collins, Colorado); Michael A. Parker (Santa Clara, California); Richard J. Dischler (Bolton, Massachusetts) |
| ABSTRACT | Technologies for densely packaging network components for large scale indirect topologies include group of switches. The group of switches includes a stack of node switches that includes a first set of ports and a stack of global switches that includes a second set of ports. The stack of node switches are oriented orthogonally to the stack of global switches. Additionally, the first set of ports are oriented towards the second set of ports and the node switches are connected to the global switches through the first and second sets of ports. Other embodiments are also described and claimed. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494712 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 12/12 (20130101) Original (OR) Class H04L 12/44 (20130101) H04L 41/12 (20130101) H04L 41/0803 (20130101) H04L 45/12 (20130101) H04L 49/15 (20130101) Wireless Communication Networks H04W 40/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220029845 | Klenk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NVIDIA Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Klenk (San Jose, California); Nan Jiang (Santa Clara, California); Larry Robert Dennison (Menden, Massachusetts); Gregory M. Thorson (Palo Alto, California) |
| ABSTRACT | A network device configured to perform scalable, in-network computations is described. The network device is configured to process pull requests and/or push requests from a plurality of endpoints connected to the network. A collective communication primitive from a particular endpoint can be received at a network device. The collective communication primitive is associated with a multicast region of a shared global address space and is mapped to a plurality of participating endpoints. The network device is configured to perform an in-network computation based on information received from the participating endpoints before forwarding a response to the collective communication primitive back to one or more of the participating endpoints. The endpoints can inject pull requests (e.g., load commands) and/or push requests (e.g., store commands) into the network. A multicast capability enables tasks, such as a reduction operation, to be offloaded to hardware in the network device. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495547 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5083 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 12/18 (20130101) H04L 12/1886 (20130101) Original (OR) Class H04L 45/74 (20130101) H04L 47/20 (20130101) H04L 47/39 (20130101) H04L 47/806 (20130101) H04L 67/26 (20130101) H04L 67/2842 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220026192 | Sinclair et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Laura Cathleen Sinclair (Boulder, Colorado); Nathan Reynolds Newbury (Boulder, Colorado); William Charles Swann (Boulder, Colorado); Jean-Daniel Deschenes (Chatelets, Canada) |
| ABSTRACT | A synchronizer for synchronizing transfer over an optical link includes a frequency reference oscillator; a tracking optical timing source; a tracking comb signal; a signal processor-controller; a comb timing discriminator; a clock frequency comb; a bidirectional terminal; a time-frequency offset measurement system; and a second comb timing discriminator. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209285 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02004 (20130101) Original (OR) Class G01B 9/02008 (20130101) G01B 9/02014 (20130101) G01B 9/02069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220025814 | Wood et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trevor Howard Wood (Clifton Park, New York); Nikolai N. Pastouchenko (Glenville, New York); Kishore Ramakrishnan (Rexford, New York); Timothy Richard DePuy (Liberty Township, Ohio); Wendy Wenling Lin (Montgomery, Ohio); Robert William Davidoff (Pittsburgh, Pennsylvania) |
| ABSTRACT | An acoustic core includes an array of resonant cells. The array may include a plurality of coupled resonant cells respectively defining an antecedent resonant space and a subsequent resonant space, with at least one cell wall having one or more wall-apertures defining a pathway between the antecedent resonant space and the subsequent resonant space. The array may include a plurality of high-frequency resonant cells respectively defining a high-frequency resonant space and being matched with respective ones of the plurality of coupled resonant cells. A cross-sectional dimension of the one or more wall-apertures defining the pathway between the antecedent resonant space and the subsequent resonant space may be less than a cross-sectional dimension of the antecedent resonant space and/or a cross-sectional dimension of the subsequent resonant space. The array may include a plurality of partitioned resonant cells that have a partition integrally formed with at least one of a corresponding one or more cell walls and transecting the corresponding resonant space with at least one surface of the partition having an interface angle that is oblique or perpendicular relative to a plane parallel to a top face and/or a bottom face of the array of resonant cells. |
| FILED | Friday, July 24, 2020 |
| APPL NO | 16/938150 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/12 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/045 (20130101) Original (OR) Class Jet-propulsion Plants F02K 1/827 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2250/282 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/172 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220023506 | Boden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott D. Boden (Atlanta, Georgia); Sreedhara Sangadala (Dallas, Georgia) |
| ABSTRACT | This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501463 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/46 (20130101) A61L 27/54 (20130101) Original (OR) Class A61L 2300/414 (20130101) A61L 2430/02 (20130101) A61L 2430/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20220024891 | De Brabander et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jef K. De Brabander (Austin, Texas); Wentian Wang (Austin, Texas) |
| ABSTRACT | The present disclosure reports an extensive medicinal chemistry evaluation of a large collection of Truncating APC-Selective Inhibitor (TASIN) compounds. The compounds were evaluated for activity against a series of colon cancer cell lines with and without truncating APC-mutations, as well as in an isogenic cell line pair reporting on the status of APC-dependent selectivity. A number of very potent and selective compounds were identified, including compounds with good metabolic stability and PK properties. The small molecules reported herein thus represent a first-in-class genotype-selective series that specifically target ape mutations present in the vast majority of CRC patients, and therefore serves as a translational platform towards a potential targeted therapy for colon cancer. |
| FILED | Wednesday, December 04, 2019 |
| APPL NO | 17/299760 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 211/10 (20130101) C07D 211/14 (20130101) C07D 211/58 (20130101) C07D 211/96 (20130101) C07D 211/98 (20130101) C07D 295/04 (20130101) C07D 401/04 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 405/04 (20130101) C07D 407/14 (20130101) C07D 413/14 (20130101) C07D 417/14 (20130101) C07D 491/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220026586 | Fertig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| ASSIGNEE(S) | Honeywell International Inc. (Morris Plains, New Jersey) |
| INVENTOR(S) | Chad Fertig (Bloomington, Minnesota); Karl D. Nelson (Plymouth, Minnesota) |
| ABSTRACT | Systems and methods for direct measurement of imbalanced optical paths using entangled photons are provided. A system includes an optical source for generating a pair of simultaneously produced photons. The system also includes first and second emitter/receivers that emit first and second photons in the pair of simultaneously produced photons towards a first and second remote reflector and receives the reflected first and second photons along first and second optical paths. Further, the system includes a mode combiner for combining the reflected first and second photons into first and second output ports. Moreover, the system includes photodetectors that detect photons from the first and second output ports. Also, the system includes a processor that measures a difference in time delay between the first and second optical paths based on a time difference of arrival of signals from the photodetectors. |
| FILED | Wednesday, July 22, 2020 |
| APPL NO | 16/936295 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/485 (20200501) Original (OR) Class Transmission H04B 10/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, January 27, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page