FedInvent™ Patent Applications
Application Details for Thursday, February 03, 2022
This page was updated on Saturday, February 05, 2022 at 04:24 PM GMT
Department of Health and Human Services (HHS)
| US 20220030837 | Leinwand et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leslie Leinwand (Boulder, Colorado); Massimo Buvoli (Boulder, Colorado); Ada Buvoli (Boulder, Colorado); Genevieve Wilson (Arvada, Colorado) |
| ABSTRACT | The inventive technology is directed to the generation of a novel transgenic mammalian model for the study of Laing distal myopathy. The novel animal model of the invention may include a transgenic animal, and preferably a transgenic mouse, expressing the β-myosin R1500P mutation transgene that produces one or more phenotypes associated with MPD1. The β-myosin R1500P mutation transgene may further be selectively expressed in fast muscle tissue of the transgenic animal. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392641 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Original (OR) Class A01K 2217/052 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8509 (20130101) C12N 2015/8527 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220030850 | Hubel et al. |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
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| INVENTOR(S) | Allison Hubel (St. Paul, Minnesota); Kathryn Lindsay Pollock (Seattle, Washington) |
| ABSTRACT | This disclosure describes a cryopreservative composition and methods for storing cells. Generally, the cryopreservative composition includes a sugar component and a sugar alcohol component, and is effective for storing and recovering cells without requiring dimethyl sulfoxide (DMSO). |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/371811 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class A01N 1/0284 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031166 | BOCTOR et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Emad M. BOCTOR (Ellicott City, Maryland); Jeeun KANG (Baltimore, Maryland); Arthur L. BURNETT (Baltimore, Maryland); Jin U. KANG (Glenelg, Maryland); Maged HARRAZ (Ellicott City, Maryland) |
| ABSTRACT | A device may obtain imaging data. The imaging data that is obtained depicts one or more body parts of a patient. A voltage sensitive dye may be applied to stain nerve tissue associated with the one or more body parts of the patient. The voltage sensitive dye may be activated by neuromodulation applied to stimulate the nerve tissue. The imaging data may capture a fluorescence of the nerve tissue based on the voltage sensitive dye being activated by neuromodulation. The device may provide the imaging data for display. |
| FILED | Tuesday, September 17, 2019 |
| APPL NO | 17/277224 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/004 (20130101) A61B 5/0071 (20130101) Original (OR) Class A61B 5/0095 (20130101) A61B 5/407 (20130101) A61B 5/4381 (20130101) A61B 90/37 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031224 | BOCTOR et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Emad M. BOCTOR (Ellicott City, Maryland); Maged HARRAZ (Ellicott City, Maryland); Ernest M. GRAHAM (Clarksville, Maryland); Jeeun KANG (Baltimore, Maryland); Raymond C. KOEHLER (Catonsville, Maryland); Adarsha MALLA (Dublin, Georgia) |
| ABSTRACT | The present disclosure is associated with monitoring health of a patient. An example electromagnetic-evoked acoustic device includes an electromagnetic component to emit energy toward tissue of a patient to cause the energy to be absorbed by the tissue; an ultrasound transmission component to transmit acoustic energy toward the tissue to cause a biological response from the tissue; and an ultrasound sensing component to sense the biological response from the tissue to permit a status of the tissue to be determined, wherein the biological response is sensed based on the energy absorbed by the tissue during the biological response. |
| FILED | Monday, November 25, 2019 |
| APPL NO | 17/309382 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0095 (20130101) A61B 5/377 (20210101) Original (OR) Class A61B 5/0507 (20130101) A61B 5/4362 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031287 | Ebbini et al. |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (MINNEAPOLIS, Minnesota) |
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| INVENTOR(S) | Emad S. Ebbini (Edina, Minnesota); Andrew J. Casper (Eau Claire, Wisconsin); Dalong Liu (Saint Paul, Minnesota); John R. Ballard (Saint Bonifacius, Minnesota) |
| ABSTRACT | A dual-mode ultrasound system provides real-time imaging and therapy delivery using the same transducer elements of a transducer array. The system may use a multi-channel driver to drive the elements of the array. The system uses a real-time monitoring and feedback image control of the therapy based on imaging data acquired using the dual-mode ultrasound array (DMUA) of transducer elements. Further, for example, multi-modal coded excitation may be used in both imaging and therapy modes. Still further, for example, adaptive, real-time refocusing for improved imaging and therapy can be achieved using, for example, array directivity vectors obtained from DMUA pulse-echo data. |
| FILED | Friday, July 09, 2021 |
| APPL NO | 17/371513 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/00 (20130101) A61B 8/08 (20130101) A61B 8/14 (20130101) A61B 8/54 (20130101) Original (OR) Class A61B 8/485 (20130101) A61B 8/0891 (20130101) A61B 8/4438 (20130101) A61B 8/4488 (20130101) A61B 8/5207 (20130101) A61B 8/5223 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 7/02 (20130101) A61N 2007/0052 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/5202 (20130101) G01S 7/52046 (20130101) G01S 15/8915 (20130101) G01S 15/8952 (20130101) G01S 15/8959 (20130101) G01S 15/8997 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031617 | Fahmy et al. |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
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| INVENTOR(S) | Tarek M. Fahmy (New Haven, Connecticut); Eric Stern (Jamaica Plain, Massachusetts); Richard A. Flavell (Guillford, Connecticut); Jason Park (New York, New York); Alyssa Siefert (Naugatuck, Connecticut); Stephen H. Wrzesinski (Slingerlands, New York) |
| ABSTRACT | A “nanolipogel” is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can be constructed so as to incorporate a variety of different chemical entities that can subsequently be released in a controlled fashion. These different incorporated chemical entities can differ dramatically with respect to size and composition. Nanolipogels have been constructed to contain co-encapsulated proteins as well as small hydrophobic drugs within the interior of the lipid bilayer. Agents incorporated within nanolipogels can be released into the milieu in a controlled fashion, for example, nanolipogels provide a means of achieving simultaneous sustained release of agents that differ widely in chemical composition and molecular weight. Additionally, nanolipogels can favorably modulate biodistribution. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399544 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) Original (OR) Class A61K 9/1271 (20130101) A61K 9/1273 (20130101) A61K 9/1277 (20130101) A61K 9/5153 (20130101) A61K 31/343 (20130101) A61K 38/1841 (20130101) A61K 38/2013 (20130101) A61K 47/24 (20130101) A61K 47/40 (20130101) A61K 47/58 (20170801) A61K 47/6849 (20170801) A61K 47/6937 (20170801) A61K 47/6951 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 16/2812 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031630 | KARP et al. |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey M. KARP (Boston, Massachusetts); Wen LI (Boston, Massachusetts); Nitin JOSHI (Boston, Massachusetts); Robert S. LANGER (Boston, Massachusetts); Rebekah MANNIX (Boston, Massachusetts); Jianhua QIU (Boston, Massachusetts); Sezin ADAY (Boston, Massachusetts) |
| ABSTRACT | Disclosed are pharmaceutical compositions formulated for delivery to the brain of a subject. The compositions include a plurality of nanoparticles (NPs) containing a brain therapeutic agent, poly(lactic-co-glycolic acid) (PLGA), and a pharmaceutically acceptable excipient selected from the group consisting of a surfactant, peptide, and combinations thereof. Also disclosed are methods of their use. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/275266 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0085 (20130101) A61K 9/5123 (20130101) A61K 9/5153 (20130101) Original (OR) Class A61K 31/7088 (20130101) A61K 38/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031633 | Saltzman et al. |
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| APPLICANT(S) | Yale University (New Haven, Connecticut) |
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| INVENTOR(S) | W. Mark Saltzman (New Haven, Connecticut); Daniel Greif (Guilford, Connecticut); Aglaia Ntokou (New Haven, Connecticut); Amy Kauffman (Kennebunkport, Maine) |
| ABSTRACT | Poly(amine-co-ester) polymers, methods of forming active agent-load polyplexes and particles therefrom, and methods of using them for delivery of nucleic acid agents with optimal uptake have been developed. Examples demonstrate critical molecular weights in combination with exposed carboxylic and/or hydroxyl groups, and methods of making. Typically, the compositions are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the compositions are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332175 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 9/5153 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031644 | DALERBA et al. |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (NEW YORK, New York) |
| INVENTOR(S) | PIERO D. DALERBA (NEW YORK, New York); SARA VIRAGOVA (NEW YORK, New York) |
| ABSTRACT | The method of treating adenoid cystic carcinoma or other cancer tumors includes the administration of an effective dosage of an inverse agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling to a patient in need thereof, alone or in combination with other cancer treatment. Non-limiting examples of an inverse agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling include 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid (commonly referred to as “BMS493”) and 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl] ethynyl]benzoic acid (commonly referred to as “AGN193109”). Alternatively, prior to administration of the inverse agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling, a direct agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling may be administered to the patient. Non-limiting examples of a direct agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling include all-trans retinoic acid (ATRA), isotretinoin, alitretinoin, and bexarotene. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/391853 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) Original (OR) Class A61K 31/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031646 | Rabinowitz et al. |
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| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); The Trustees of Princeton University (Princeton, New Jersey) |
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| INVENTOR(S) | Joshua D. Rabinowitz (Princeton, New Jersey); Craig B. Thompson (New York, New York); Jiangbin Ye (New York, New York); Jing Fan (Princeton, New Jersey); Jurre Kamphorst (Princeton, New Jersey) |
| ABSTRACT | Methods and compositions for treating cancer and other disorders associated with undesired cellular proliferation are provided comprising administering to a subject in need thereof an amino acid mixture, wherein the amino acid mixture comprises glycine, optionally comprising at least a 2:1 molar ratio of glycine to serine. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502665 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/175 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0056 (20130101) A61K 31/198 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/7068 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031656 | MOELLERING et al. |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Raymond MOELLERING (Chicago, Illinois); John COUKOS (Chicago, Illinois); Gihoon LEE (Chicago, Illinois); Jae Won CHANG (Chicago, Illinois); Gokhan MUTLU (Chicago, Illinois) |
| ABSTRACT | Embodiments are directed to a series of novel small molecule activators of NRF2 dependent gene expression that are evaluated in an effort to develop therapeutic methods against diseases with deregulated KEAP1-NRF2 signaling. |
| FILED | Monday, October 14, 2019 |
| APPL NO | 17/309017 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031661 | RIVERA et al. |
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| APPLICANT(S) | UNIVERSITY OF KANSAS (Lawrence, Kansas); OKLAHOMA STATE UNIVERSITY (Stillwater, Oklahoma) |
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| INVENTOR(S) | Mario RIVERA (Baton Rouge, Louisiana); Huili YAO (Baton Rouge, Louisiana); Richard A. BUNCE (Stillwater, Oklahoma); Baskar NAMMALWAR (San Diego, California); Krishna Kumar GNANASEKARAN (Mississauga, Canada); Kate ESHELMAN (Alexandria, Virginia); Achala N.D. PUNCHI HEWAGE (Lawrence, Kansas); Scott LOVELL (Shawnee, Kansas) |
| ABSTRACT | The present technology provides compounds of Formula I and related methods for treating a bacterial infection as well as methods for inhibiting interaction of a bacterioferritin and a bacterioferritin-associated ferredoxin. |
| FILED | Tuesday, December 03, 2019 |
| APPL NO | 17/299267 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/502 (20130101) A61K 31/4035 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 209/48 (20130101) C07D 237/32 (20130101) C07D 401/12 (20130101) C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031665 | Mousa et al. |
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| APPLICANT(S) | SHIFA BIOMEDICAL CORPORATION (Malvern, Pennsylvania) |
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| INVENTOR(S) | Shaker A. Mousa (Wynantskill, New York); Nabil A. Elshourbagy (West Chester, Pennsylvania); Harold V. Meyers (Weston, Massachusetts); Sherin Salaheldin Abdel-Meguid (Exton, Pennsylvania) |
| ABSTRACT | Disclosed are Nanoformulated compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), as well as therapeutic methods for use of such compounds to reduce LDL- and related cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia. |
| FILED | Tuesday, November 05, 2019 |
| APPL NO | 17/276543 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5138 (20130101) A61K 9/5153 (20130101) A61K 9/5161 (20130101) A61K 31/422 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/55 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031672 | Bulterys et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Philip Bulterys (Los Angeles, California); Jeffery F. Miller (Santa Monica, California); Robert D. Damoiseaux (Beverly Hills, California); Christopher Todd French (Los Angeles, California) |
| ABSTRACT | Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) are Tier-1 select pathogens that cause highly lethal human infections with limited therapeutic options. Intercellular spread is a hallmark of Burkholderia pathogenesis and its prominent ties to virulence make it an attractive therapeutic target. We developed a high-throughput cell-based phenotypic assay and screened ˜220,000 small molecules for their ability to disrupt intercellular spread by Burkholderia thailandensis, a BSL-2 surrogate for these pathogens. 268 hits were identified, and cross-species validation found 32 hits that also disrupt intercellular spread by Bp and/or Bm. In a fulminant murine model of respiratory melioidosis, treatment with a number of these agents was significantly more effective than ceftazidime, the current drug of choice, for improving patient survival and decreasing bacterial counts in major organs. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/279015 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031673 | Sell et al. |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Christian Sell (Conshohocken, Pennsylvania); Timothy Nacarelli (Norristown, Pennsylvania); Ashley Azar (North Wales, Pennsylvania) |
| ABSTRACT | The present invention includes compositions and methods for treating or preventing certain dermal disorders including dermal atrophy, pseudoscars, actinic keratosis, seborrheic or actinic keratoses, lentigines, focal areas of dermal thickening, and coarse wrinkles. In certain embodiments, the compositions useful within the invention comprise a therapeutically effective amount of a mTORC1 inhibitor and a dermatologically acceptable carrier. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399763 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) Original (OR) Class A61K 31/501 (20130101) A61K 31/519 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031674 | Schultz et al. |
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| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
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| INVENTOR(S) | Michael K. Schultz (Iowa City, Iowa); Somya Kapoor (Iowa City, Iowa); Douglas R. Spitz (Iowa City, Iowa) |
| ABSTRACT | The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 16/945323 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/66 (20130101) A61K 31/198 (20130101) A61K 31/437 (20130101) Original (OR) Class A61K 31/4706 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031711 | Coghill et al. |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James M. Coghill (Wake Forest, North Carolina); Kenneth A. Fowler (Durham, North Carolina) |
| ABSTRACT | The present invention relates to methods for attenuating graft-versus-host disease after transplantation of a graft comprising hematopoietic stem cells in a subject. The invention further relates to methods of limiting opportunistic microbial infections in a subject after transplantation of a graft comprising hematopoietic stem cells. |
| FILED | Tuesday, December 03, 2019 |
| APPL NO | 17/298776 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/575 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031731 | Singh et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ionis Pharmaceuticals, Inc. (Carlsbad, California); THE UNITED STATES OF AMERICA , AS REPRESENTED BY THE SECRETARY , DEPARTMENT OF HEALTH AND HUMAN SERV (Rockville, California) |
| ASSIGNEE(S) | Ionis Pharmaceuticals, Inc. (Carlsbad, California); Ionis Pharmaceuticals, Inc. (Rockville, Maryland) |
| INVENTOR(S) | Priyam Singh (San Diego, California); Frank Rigo (Carlsbad, California); Tom Misteli (Bethesda, Maryland); Madaiah Puttaraju (Bethesda, Maryland) |
| ABSTRACT | The present disclosure provides compounds comprising oligonucleotides complementary to a portion of the LMNA gene. Such compounds are useful for modulating the expression of LMNA in a cell or animal, and in certain instances reducing the amount of progerin mRNA and/or progerin protein. Progerin mRNA results from aberrant splicing of LMNA and is translated to generate progerin protein. Accumulation of progerin protein causes Hutchinson-Gilford progeria syndrome (HOPS), a premature aging disease. In certain embodiments, hybridization of oligonucleotides complementary to a portion of the LMNA gene results in a decrease in the amount of progerin mRNA and/or progerin protein. In certain embodiments, oligonucleotides are used to treat Hutchinson-Gilford Progeria Syndrome. |
| FILED | Friday, September 20, 2019 |
| APPL NO | 17/277397 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220031771 — MICROENCAPSULATED AND CHROMOSOME INTEGRATED COMPOSITIONS FOR L-DOPA MICROBIOME THERAPY
| US 20220031771 | Kanthasamy et al. |
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| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anumantha G. Kanthasamy (Ames, Iowa); Gregory Phillips (Ames, Iowa); Ahmed Abdalla (Ames, Iowa); Nicholas John Backes (Ames, Iowa); Piyush Padhi (Ames, Iowa) |
| ABSTRACT | The present invention generally provides methods and compositions for the treatment of Parkinson's disease, Alzheimer's disease, depression, anxiety, and memory deficits. The invention relates to recombinant microorganisms, particularly gut-colonizing probiotics, modified to produce L-DOPA as well as microcapsules and lyophilized formulations comprising the same. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/304444 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 9/5036 (20130101) A61K 31/165 (20130101) A61K 31/198 (20130101) A61K 35/741 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031821 | Munshi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikhil C. Munshi (Needham, Massachusetts); Kenneth C. Anderson (Wellesley, Massachusetts); Jooeun Bae (West Roxbury, Massachusetts) |
| ABSTRACT | The disclosure features, inter alia, immunogenic XBP1-, CD138-, and CS1-derived peptides (and pharmaceutical compositions thereof). The peptides can be used in a variety of methods such as methods for inducing an immune response, methods for producing an antibody, and methods for treating a cancer (e.g., a plasma cell disorder such as multiple myeloma or Waldenstrom's macroglobulinemia). The peptides can also be included in WIC molecule multimer compositions and used in, e.g., methods for detecting a T cell in a population of cells. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370412 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/0011 (20130101) Original (OR) Class Peptides C07K 14/4702 (20130101) C07K 14/70507 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031827 | Sampson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | Duke University (Durham, North Carolina) |
| INVENTOR(S) | John H Sampson (Durham, North Carolina); Duane A Mitchell (Durham, North Carolina); Kristen A Batich (Durham, North Carolina); Michael D Gunn (Durham, North Carolina) |
| ABSTRACT | Pre-conditioning a vaccine site with a potent recall antigen such as tetanus/diphtheria (Td) toxoid can significantly improve the lymph node homing and efficacy of tumor antigen-specific DC vaccines. Patients given Td had enhanced DC migration bilaterally and significantly improved survival. In mice, Td pre-conditioning also enhanced bilateral DC migration and suppressed tumor growth in a manner dependent on the chemokines CCL3 and CCL21 and Td-activated CD4+ T cells. Interference with any component of this axis markedly reduced Td-mediated DC migration and antitumor responses. Our clinical studies and corroborating investigations in mice suggest that pre-conditioning with a potent recall antigen represents a viable strategy to increase DC homing to lymph nodes and improve antitumor immunotherapy. |
| FILED | Sunday, July 11, 2021 |
| APPL NO | 17/372475 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/195 (20130101) A61K 39/05 (20130101) A61K 39/08 (20130101) Original (OR) Class A61K 39/0011 (20130101) A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/092 (20130101) A61K 39/102 (20130101) A61K 49/06 (20130101) A61K 49/0008 (20130101) A61K 2039/53 (20130101) A61K 2039/54 (20130101) A61K 2039/58 (20130101) A61K 2039/70 (20130101) A61K 2039/545 (20130101) A61K 2039/585 (20130101) A61K 2039/5154 (20130101) A61K 2039/5158 (20130101) A61K 2039/55544 (20130101) Peptides C07K 14/33 (20130101) C07K 14/34 (20130101) C07K 14/285 (20130101) C07K 14/523 (20130101) C07K 14/3156 (20130101) C07K 14/4748 (20130101) C07K 2319/55 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16134 (20130101) C12N 2710/16171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031834 | MASCOLA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | John R. MASCOLA (Rockville, Maryland); Jeffrey C. BOYINGTON (Clarksburg, Maryland); Hadi M. YASSINE (Doha, Qatar); Peter D. KWONG (Washington, District of Columbia); Barney S. GRAHAM (Rockville, Maryland); Masaru KANEKIYO (Chevy Chase, Maryland) |
| ABSTRACT | Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504002 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/55555 (20130101) Peptides C07K 14/005 (20130101) C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031835 | He et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Linling He (San Diego, California); Jiang Zhu (San Diego, California) |
| ABSTRACT | The present invention provides novel nanoparticle presented vaccine compositions that are stabilized with a locking domain. Various immunogens can be employed in the preparation of the vaccine compositions, including viral immunogens such as HIV-1 and Ebola viral immunogens, and non-viral immunogens such as immunogens derived from bacteria, parasites and mammalian species. The invention also provides methods of using such vaccine compositions in various therapeutic applications, e.g., for preventing or treating viral infections. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/386289 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031848 | Ogle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brenda M. Ogle (Edina, Minnesota); Wei-Han Lin (Minneapolis, Minnesota); Molly E. Kupfer (Minneapolis, Minnesota); Didarul Bhuiyan (Milwaukee, Wisconsin) |
| ABSTRACT | Example bioinks that can be used for three-dimensional (3D) printing of structures are described. In one example, a bioink composition may include gelatin methacrylate and collagen methacrylate. In some examples, the bioink may also include additional components such as lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP). The bioink may promote stem cell differentiation into cardiomyocytes to generate functional 3D structures, for example. |
| FILED | Friday, October 18, 2019 |
| APPL NO | 17/309037 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/24 (20130101) A61K 47/32 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3834 (20130101) A61L 27/3895 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031867 | Nedergaard et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maiken Nedergaard (Rochester, New York); Benjamin Plog (Rochester, New York); Humberto Mestre (Rochester, New York) |
| ABSTRACT | This invention relates to improving delivery of agents to the central nervous system. |
| FILED | Monday, September 30, 2019 |
| APPL NO | 17/280606 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0085 (20130101) A61K 45/06 (20130101) A61K 49/0058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031913 | Vegas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arturo Vegas (Belmont, Massachusetts); Joshua C. Doloff (Quincy, Massachusetts); Omid Veiseh (Bellaire, Texas); Minglin Ma (Ithaca, New York); Robert S. Langer (Newton, Massachusetts); Daniel G. Anderson (Framingham, Massachusetts) |
| ABSTRACT | Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/377124 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/4816 (20130101) A61K 9/5036 (20130101) A61K 35/39 (20130101) A61K 47/36 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/085 (20130101) Original (OR) Class A61L 31/10 (20130101) A61L 33/08 (20130101) Heterocyclic Compounds C07D 487/04 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0084 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 5/0677 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032023 | AKSIT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aykut AKSIT (New York, New York); Jeffrey W. KYSAR (New York, New York); Anil K. LALWANI (New York, New York) |
| ABSTRACT | A microneedle having a body including a base, shaft and pointed tip, and at least one lumen disposed within the shaft. The lumen having an opening that is offset from the tip and open to the exterior of the microneedle. |
| FILED | Saturday, October 16, 2021 |
| APPL NO | 17/503304 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0045 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/87 (20210501) A61M 31/00 (20130101) Original (OR) Class A61M 2210/0662 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032060 | BHADRA et al. |
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| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Narendra BHADRA (Cleveland, Ohio); Tina L. VRABEC (Cleveland, Ohio); Niloy BHADRA (Cleveland, Ohio); Kevin L. KILGORE (Cleveland, Ohio) |
| ABSTRACT | The present disclose relates to intravertebral electrical block of spinal transmission of neural signals (at least a portion of sensory signals from the peripheral nervous system and/or at least a portion of motor signals to the peripheral nervous system). At least one intravertebral electrode can be located at a level of a spinal cord of a subject. At least one waveform generator can be coupled to the at least one intravertebral electrode and configured to generate an electrical signal that is sent to the at least one intravertebral electrode for application to the level of the spinal cord of the subject. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 17/278843 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/20 (20130101) A61N 1/0551 (20130101) A61N 1/36071 (20130101) Original (OR) Class A61N 1/36139 (20130101) A61N 1/37247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032074 | Akbari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yama Akbari (Irvine, California); Robert H. Wilson (Irvine, California); Christian Crouzet (Irvine, California); Bernard Choi (Irvine, California); Bruce J. Tromberg (Irvine, California) |
| ABSTRACT | Electrophysiologic biomarkers for prognostication of neurological outcome are described herein. An inverse correlation was found between timing of a cortical spreading depolarization (SD) wave and neurological outcome as tested at 24 hours post-CPR. Additionally, a minor image of this SD was identified as a “repolarization (RP) wave.” Quantifying features of SD and RP during cardiac arrest and cardiopulmonary resuscitation (CPR) provide important metrics for diagnosis and prognosis of neurological injury from hypoxia-ischemia and can serve as an early prognostication tool for predicting outcome at subsequent days after successful CPR. This discovery may also allow for novel therapeutic interventions to improve neurological recovery after hypoxia-ischemia insults. |
| FILED | Monday, September 23, 2019 |
| APPL NO | 17/277616 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 31/005 (20130101) A61H 2201/5094 (20130101) A61H 2230/085 (20130101) A61H 2230/105 (20130101) A61H 2230/255 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/39044 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032088 | FRIEDMAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Integrated Sensors, LLC (Ottawa Hills, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter S. FRIEDMAN (Ottawa Hills, Ohio) |
| ABSTRACT | Embodiments are directed generally to an ionizing-radiation beamline monitoring system that includes a vacuum chamber structure with vacuum compatible flanges through which an incident ionizing-radiation beam enters the monitoring system. Embodiments further include at least one scintillator within the vacuum chamber structure that can be at least partially translated in the ionizing-radiation beam while oriented at an angle greater than 10 degrees to a normal of the incident ionizing-radiation beam, a machine vision camera coupled to a light-tight structure at atmospheric/ambient pressure that is attached to the vacuum chamber structure by a flange attached to a vacuum-tight viewport window with the camera and lens optical axis oriented at an angle of less than 80 degrees with respect to a normal of the scintillator, and at least one ultraviolet (“UV”) illumination source facing the scintillator in the ionizing-radiation beam for monitoring a scintillator stability comprising scintillator radiation damage. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/451517 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/00 (20130101) A61N 5/1045 (20130101) A61N 5/1048 (20130101) A61N 5/1049 (20130101) A61N 5/1064 (20130101) A61N 5/1067 (20130101) Original (OR) Class Measurement of Nuclear or X-radiation G01T 1/29 (20130101) G01T 1/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032119 | Adamczyk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Gabriel Adamczyk (Madison, Wisconsin); Alexander Raymond Dawson-Elli (Madison, Wisconsin) |
| ABSTRACT | Aspects of the present disclosure are directed toward apparatuses and methods for rendering haptic environments, such as may be used in rehabilitation. As may be implemented in accordance with one or more embodiments, haptic rehabilitative movement is effected by providing feedback signals characterizing sensed engagement of a user's lower extremity with a crank coupled to a shaft that is driven by a motor, and controlling movement of the crank in response to the feedback signals. Force may be provided by the motor and shaft, by applying control inputs to the motor that cause the motor and crank to render respective haptic environments while engaged with the user's lower extremity, via rotation of the shaft. The haptic environments may include one or both of impedance-based haptic environments and admittance-based haptic environments. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/393197 |
| CURRENT CPC | Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 22/0605 (20130101) Original (OR) Class A63B 24/0062 (20130101) A63B 24/0075 (20130101) A63B 24/0087 (20130101) A63B 2022/0611 (20130101) A63B 2022/0652 (20130101) A63B 2220/30 (20130101) A63B 2220/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032257 | Love et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Christopher Love (Somerville, Massachusetts); Hidde L. Ploegh (Brookline, Massachusetts); Jehnna Ronan (Chester, New Hampshire) |
| ABSTRACT | Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody. |
| FILED | Monday, September 20, 2021 |
| APPL NO | 17/479515 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Original (OR) Class B01J 2219/0074 (20130101) B01J 2219/00317 (20130101) B01J 2219/00527 (20130101) B01J 2219/00585 (20130101) B01J 2219/00675 (20130101) B01J 2219/00722 (20130101) B01J 2219/00725 (20130101) B01J 2219/00734 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/50853 (20130101) B01L 2200/12 (20130101) B01L 2200/025 (20130101) B01L 2300/12 (20130101) B01L 2300/0819 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6452 (20130101) G01N 33/505 (20130101) G01N 33/531 (20130101) G01N 33/543 (20130101) G01N 33/577 (20130101) G01N 33/5052 (20130101) G01N 33/6854 (20130101) G01N 33/54366 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 436/809 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/24 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032295 | Kirkpatrick et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LUMINOSTICS, INC. (Milpitas, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Kirkpatrick (San Jose, California); Balakrishnan Raja (San Jose, California); Andrew Paterson (Fremont, California) |
| ABSTRACT | Methods, apparatuses, and computer program products for preparation of samples for use with in vitro diagnostic tests or analytical assays for detecting one or more analytes. For example, certain embodiments may relate to diagnostic tests performed on human subjects for a variety of applications related to health, medical, and wellness testing. Other embodiments may relate to testing in various applications. Further embodiments may relate to processing environmental samples for detection of various analytes of biological or non-biological origin. Additional embodiments may relate to various applications that require mixing an arbitrary sample with a precise amount of one or more reagents. |
| FILED | Friday, April 30, 2021 |
| APPL NO | 17/246562 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2200/16 (20130101) B01L 2200/0684 (20130101) B01L 2200/0689 (20130101) B01L 2300/042 (20130101) B01L 2300/044 (20130101) B01L 2400/0481 (20130101) B01L 2400/0487 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033372 | Volpe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Matthew R. Volpe (Cambridge, Massachusetts); Emily Patricia Balskus (Somerville, Massachusetts); Matthew Ryan Wilson (Cambridge, Massachusetts) |
| ABSTRACT | The technology described herein is directed to compounds which are substrates for ClbP, acting as fluorescent probes for ClbP activity. Further provided herein are methods for measuring ClbP activity, screening for ClbP inhibitors, detecting colibactin, and/or diagnosing cancer, which utilize the substrate compounds. |
| FILED | Thursday, May 20, 2021 |
| APPL NO | 17/325747 |
| CURRENT CPC | Heterocyclic Compounds C07D 311/16 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033382 | El-Deiry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wafik S. El-Deiry (Philadelphia, Pennsylvania); Xiaobing Tian (Philadelphia, Pennsylvania) |
| ABSTRACT | Prodigiosin analogs which reactivate the p53 pathway are provided, as well as compositions of these compounds, and methods for reactivation of the p53 pathway using these compounds are provided. The prodigiosin analogs may be used to treat cancer in which p53 mutation plays a role, including prostate cancer, breast cancer, kidney cancer, ovarian cancer, lymphoma, leukemia, and glioblastoma, among others. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/076469 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 403/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033385 | NATALE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Linnaeus Therapeutics, Inc. (Haddonfield, New Jersey) |
| ASSIGNEE(S) | Linnaeus Therapeutics, Inc. (Haddonfield, New Jersey) |
| INVENTOR(S) | Christopher NATALE (Philadelphia, Pennsylvania); Patrick T. MOONEY (Haddonfield, New Jersey); Tina GARYANTES (Warren, New Jersey); Wayne LUKE (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure provides 1) an enantiomerically purified compound SRR G-1, or a derivative thereof, including specific crystal forms, salts and co-crystals that modulates G protein-coupled estrogen receptor activity, 2) pharmaceutical and cosmetic compositions comprising an enantiomerically purified SRR G-1, or a derivative thereof, and 3) methods of treating or preventing disease states and conditions and cosmetic conditions mediated through these receptors and related methods thereof in humans and animals. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/184870 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/07 (20130101) C07B 2200/13 (20130101) Heterocyclic Compounds C07D 405/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033387 | Morris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (Bethesda, Massachusetts) |
| ASSIGNEE(S) | The USA, as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Joel Morris (Rockville, Maryland); Donn G. Wishka (Middletown, Maryland); Omar Diego Lopez (Walkersville, Maryland) |
| ABSTRACT | Halogenated analogs of 5-aza-2′-deoxycytidine, such as halogenated analogs of 5-aza-4′-thio-2′-deoxycytidine (5-aza-T-dCyd) are described. Pharmaceutical compositions including a halogenated analog and methods of using the halogenated analogs to inhibit neoplasia are described. In some examples, the halogenated analogs have a structure according to formula Ia, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof: |
| FILED | Monday, September 23, 2019 |
| APPL NO | 17/278625 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Heterocyclic Compounds C07D 409/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033393 | Makriyannis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MAKScientific, LLC (Burlington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandros Makriyannis (Watertown, Massachusetts); Kiran Vemuri (Boston, Massachusetts) |
| ABSTRACT | The present invention relates to novel compounds that can act as antidotes for treating “Acute Cannabinoid Overdose” produced by classical cannabinoids such as Δ9-tetrahydrocannabinol (THC) and several synthetic psychoactive cannabinoids (SPCs). The cannabis constituent THC exerts its psychotropic effects via CB1 receptor activation and SPCs mimic the effects of THC with higher potency and severe neurotoxicity. Compounds disclosed in this invention, their enantiomers, diastereomers, geometric isomers, racemates, tautomers, rotamers, atropisomers, metabolites, N-oxides, salts, solvates, hydrates, isotopic variations and their polymorphic forms can be therapeutically useful in an emergency setting for counteracting the intoxicating effects of acute THC ingestion and SPC overdose. Also, aspects of the invention are concerned with pyrazoles, imidazoles, triazoles, thiazoles, oxazoles, dihydropyrazoles, pyrrolidinones, azetidines, oxyazetidines and azaspiro[3.3]heptanes with unique pharmacokinetic and pharmacodynamic properties for treating “Acute Cannabinoid Overdose”. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/392191 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/02 (20180101) Heterocyclic Compounds C07D 205/04 (20130101) C07D 207/273 (20130101) C07D 231/14 (20130101) C07D 417/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033404 | SIBLEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WASHINGTON UNIVERSITY (ST. LOUIS, Missouri); THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts) |
| ASSIGNEE(S) | WASHINGTON UNIVERSITY (ST. LOUIS, Missouri); THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts) |
| INVENTOR(S) | L. DAVID SIBLEY (ST. LOUIS, Missouri); JOSHUA RADKE (ST. LOUIS, Missouri); EAMON COMER (CAMBRIDGE, Massachusetts); MARSHALL MORNINGSTAR (CAMBRIDGE, Massachusetts); BRUNO MELILLO (CAMBRIDGE, Massachusetts) |
| ABSTRACT | Provided herein are compounds useful for the treatment of diseases caused by infections of T. gondii, and closely related parasites. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions including veterinary compositions and may be used in methods of treatment and/or prophylaxis of disease. |
| FILED | Wednesday, September 18, 2019 |
| APPL NO | 17/276997 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/505 (20130101) A61K 31/635 (20130101) A61K 31/7056 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/10 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033424 | Ahrens et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric T. Ahrens (Encinitas, California); Stephen Adams (Poway, California); Chao Wang (La Jolla, California) |
| ABSTRACT | This disclosure provides compositions of SALTAME core containing compounds and associated methods for use in tracking cells by magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and related methods. |
| FILED | Monday, December 09, 2019 |
| APPL NO | 17/311299 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/106 (20130101) A61K 49/1806 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 11/005 (20130101) Original (OR) Class C07F 15/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033426 | Zakaria et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | A B M Zakaria (Danbury, Connecticut); Fahmeed Hyder (Cheshire, Connecticut); Samuel Maritim (Cambridge, Massachusetts); Jelena Milhailovic (New Haven, Connecticut); Daniel Coman (New Haven, Massachusetts) |
| ABSTRACT | In one aspect, the present disclosure relates to a Magnetic Resonance Imaging (MRI) and Spectroscopic Imaging (MRSI) agent wherein the agent comprises a polyazamacrocyclic ligand coordinated to a first row transition metal ion. In another aspect, the disclosure relates to a method of using the MRI/MRSI agents of the present disclosure to monitor tissue temperature and/or pH in a patient in need thereof. In another aspect, the disclosure relates to a method of using the MRI/MRSI agents of the present disclosure to monitor the efficacy of a cancer treatment in a patient in need thereof. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387258 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/17 (20130101) A61K 31/44 (20130101) A61K 31/436 (20130101) A61K 31/495 (20130101) A61K 39/3955 (20130101) A61K 49/106 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 15/025 (20130101) C07F 15/045 (20130101) C07F 15/065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033429 | Rohr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jurgen Rohr (Lexington, Kentucky); Oleg Tsodikov (Lexington, Kentucky); Markos Leggas (Lexington, Kentucky); Caixia Hou (Lexington, Kentucky); Joseph Eckenrode (Lexington, Tennessee); Prithiba Mitra (Lexington, Kentucky); Abhisek Mandal (Lexington, Kentucky) |
| ABSTRACT | Mithramycin (MTM) short side chain ketone (SK) derivatives and MTM short side chain diketone (SDK) derivatives are provided. The MTM SK and MTM SDK derivatives are useful for treatment of cancer or neuro-diseases associated with an aberrant erythroblast transformation-specific transcription factor. Unique MTM SK and MTM SDK derivatives have increased selectively toward ETS transcription factor. |
| FILED | Friday, September 20, 2019 |
| APPL NO | 17/278070 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033437 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guangshun Wang (Omaha, Nebraska); Biswajit Mishra (Omaha, Nebraska); Jayaram Lakshmaiah Narayana (Omaha, Nebraska) |
| ABSTRACT | Antimicrobial peptides and methods of use are provided. |
| FILED | Friday, June 28, 2019 |
| APPL NO | 17/278532 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033447 | Dong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min Dong (Weatogue, Connecticut); Liang Tao (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein are botulinum neurotoxin (BoNT) polypeptides with a modified BoNT/B4 receptor binding domain (B4-HC) having amino acid mutations that modify the binding of the BoNT to the human SytII receptor. Specific mutations and combinations of mutations are disclosed. Isolated modified HCs, polypeptides comprising such modified HCs, chimeric molecules, pharmaceutical compositions, and methods of making and using the same are also disclosed. Methods of identifying additional such modified receptor binding domains, are further disclosed. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400441 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/33 (20130101) Original (OR) Class C07K 2319/55 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Enzymes C12Y 304/24069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033449 | PAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhuo-Hua PAN (Troy, Michigan) |
| ABSTRACT | The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant ChR2 protein. Methods of the invention include administering a composition comprising a mutant ChR2 to a subject to preserve, improve, or restore phototransduction. Preferably, the compositions and methods of the invention are provided to a subject having impaired vision, thereby restoring vision to normal levels. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/202064 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/00 (20130101) C07K 14/405 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033453 | Cochran et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer R. Cochran (Stanford, California); Douglas S. Jones, II (Stanford, California); Ping-Chuan Tsai (Stanford, California) |
| ABSTRACT | The NK1 fragment of hepatocyte growth factor (HGF) binds to and activates the Met receptor, a transmembrane receptor tyrosine kinase that plays a critical role in embryonic development and organ formation. The instant application discloses NK1 variant polypeptides which act as agonists or antagonists of HGF. Further disclosed are covalently linked NK1 variant polypeptides. Many of the disclosed variant polypeptides possess improved stability characteristics. |
| FILED | Monday, March 22, 2021 |
| APPL NO | 17/208483 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/4753 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033464 | VIJAYANAND et al. |
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| FUNDED BY |
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| APPLICANT(S) | La Jolla Institute for Immunology (La Jolla, California); University of Southampton (Southampton Hampshire, United Kingdom) |
| ASSIGNEE(S) | La Jolla Institute for Immunology (La Jolla, California); University of Southampton (Southampton Hampshire, United Kingdom) |
| INVENTOR(S) | Pandurangan VIJAYANAND (La Jolla, California); Ferhat AY (La Jolla, California); Divya SINGH (La Jolla, California); Anusha Preethi GANESAN (La Jolla, California); Bharat PANWAR (La Jolla, California); Christian OTTENSMEIER (Southampton Hampshire, United Kingdom) |
| ABSTRACT | Disclosed herein are isolated follicular helper T cell (TFH) and engineered follicular helper T cell (TFH) and methods of isolating or engineering such cells. Further disclosed herein are methods of using such cells for treating diseases, such as cancer. |
| FILED | Friday, August 23, 2019 |
| APPL NO | 17/270403 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/521 (20130101) C07K 14/7051 (20130101) C07K 14/70514 (20130101) Original (OR) Class C07K 2319/02 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6467 (20130101) Enzymes C12Y 304/21079 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033475 | Arruda et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Valder R. Arruda (Philadelphia, Pennsylvania); Benjamin Samelson-Jones (Philadelphia, Pennsylvania) |
| ABSTRACT | Factor VIII variants and methods of use thereof are disclosed. |
| FILED | Wednesday, October 23, 2019 |
| APPL NO | 17/279961 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/755 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033489 | CHATILA et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Talal Amine CHATILA (Belmont, Massachusetts); Hani HARB (Boston, Massachusetts); Brittany ESTY (Boston, Massachusetts); Wanda PHIPATANAKUL (Boston, Massachusetts); Lisa M. BARTNIKAS (Boston, Massachusetts) |
| ABSTRACT | Described herein are methods and compositions for treating asthma. Aspects of the invention relates to administering to a subject an agent that inhibits IL-6 signaling. Another aspect of the invention relates to administering the anti-IL-6R antibody, tocilizumab, to a subject in need thereof. |
| FILED | Wednesday, December 04, 2019 |
| APPL NO | 17/299664 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/06 (20180101) Peptides C07K 16/248 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033493 | Morgenstern et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Travis Morgenstern (New York, New York); Henry M Colecraft (New Jersey, New Jersey) |
| ABSTRACT | The present disclosure provides, inter alia, nanobodies targeting a CaVβ auxiliary subunit and compositions thereof. Methods for blocking a High-Voltage Activated Calcium Channel (HVACC) using such compositions, methods for selectively targeting a population of cells in a subject, and methods for treating or ameliorating the effects of a disease in a subject are also provided. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/486394 |
| CURRENT CPC | Peptides C07K 16/28 (20130101) Original (OR) Class C07K 2317/22 (20130101) C07K 2317/569 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 9/104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033502 | Freeman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gordon J. Freeman (Brookline, Massachusetts); Yanping Xiao (Brookline, Massachusetts) |
| ABSTRACT | The present invention relates to methods for upregulating immune responses using combinations of anti-RGMb and anti-PD-1 agents. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/409118 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/28 (20130101) C07K 16/2818 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033506 | Weissman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Irving L. Weissman (Stanford, California); Stephen Willingham (Mountain View, California); Doris Po Yi Ho (Daly City, California); Piero D. Dalerba (New York, New York); Kelly Marie McKenna (Palo Alto, California); Jens-Peter Volkmer (Menlo Park, California) |
| ABSTRACT | Methods are provided for targeting cells for depletion, including without limitation cancer cells, in a regimen comprising contacting the targeted cells with a combination of agents, including (i) an agent that blockades CD47 activity; and (ii) an antibody that specifically binds to EGFR. In some embodiments the cancer cells have a mutated form of one or more of KRAS, NRAS or BRAF. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/411953 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39558 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2803 (20130101) C07K 16/2839 (20130101) C07K 16/2863 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033512 | Deb |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arjun Deb (Los Angeles, California) |
| ABSTRACT | In certain aspects, provided herein are inhibitory anti-ENPP1 antibodies and antigen binding fragments thereof. In some aspects, provided herein are methods of treating myocardial infarction using the antibodies provided herein. In certain aspects, provided herein are nucleic acid molecules encoding the antibodies provided herein, host cells comprising such nucleic acids, and methods of making the antibodies provided herein using such host cells. In some aspects, also provided herein are pharmaceutical compositions comprising the antibodies provided herein. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306544 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 16/40 (20130101) C07K 16/2896 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/52 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033773 | Thomson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. Thomson (Madison, Wisconsin); Nicholas E. Propson (Houston, Texas); Michael P. Schwartz (Madison, Wisconsin); Zhonggang Hou (Madison, Wisconsin); Gene I. Uenishi (Madison, Wisconsin); Igor I Slukvin (Verona, Wisconsin); William L. Murphy (Waunakee, Wisconsin); Jue Zhang (Madison, Wisconsin) |
| ABSTRACT | The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405579 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 5/0622 (20130101) Original (OR) Class C12N 5/0645 (20130101) C12N 5/0647 (20130101) C12N 5/0697 (20130101) C12N 2501/22 (20130101) C12N 2501/999 (20130101) C12N 2506/02 (20130101) C12N 2513/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5014 (20130101) G01N 33/5058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033774 | OH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David OH (San Francisco, California); Lawrence FONG (San Francisco, California); Serena KWEK MACPHEE (San Francisco, California); Chun Jimmie YE (San Francisco, California); Chien-Chun Steven PAI (San Francisco, California) |
| ABSTRACT | Provided herein, inter alia, are compositions and methods for treating bladder cancer, including CD4+T cells that can be cultured ex vivo to generate a population of cytotoxic CD4+T cells capable of killing bladder cancer tumor cells. Pharmaceutical compositions containing such a cytotoxic CD4+T cell population, as well as methods for treating an individual having or suspected of having bladder cancer are also provided. |
| FILED | Tuesday, April 16, 2019 |
| APPL NO | 17/047975 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) Original (OR) Class C12N 2501/2302 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033783 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); Nationwide Children's Hospital (Columbus, Ohio); The Ohio State University (Columbus, Ohio) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois); Nationwide Children's Hospital (Columbus, Ohio); The Ohio State University (Columbus, Ohio) |
| INVENTOR(S) | Jianrong LI (Dublin, Ohio); Mark E. PEEPLES (Bexley, Ohio); Chuan HE (Chicago, Illinois); Stefan NIEWIESK (Dublin, Ohio); Mijia LU (Columbus, Ohio); Miaoge XUE (Columbus, Ohio); Zijie ZHANG (Chicago, Illinois); Boxuan ZHAO (Palo Alto, California) |
| ABSTRACT | The current disclosure relates to methods, compositions and kits for detecting modified adenosine in a target RNA molecule. Aspects relate to a method for detecting modified adenosine in a target ribonucleic acid (RNA) comprising contacting the target RNA with an adenosine deaminase enzyme (adenosine deaminase, RNA-specific) to generate a target RNA with deaminated adenosines and sequencing the target RNA with deaminated adenosines; wherein the modified adenosine is detected when the nucleotide sequence includes adenosine within a m6A motif. |
| FILED | Friday, October 18, 2019 |
| APPL NO | 17/309038 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2760/18522 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033785 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Christopher Gerard Wilson (Waltham, Massachusetts); Peter J. Chen (Somerville, Massachusetts) |
| ABSTRACT | The disclosure provides programmable methylation “writers” and demethylation “erasers” for editing the methylation state of RNA targets, e.g., an RNA transcriptome. In particular, the disclosure provides RNA methylation editor polynucleotide contracts and vectors comprising (i) an RNA programmable RNA binding domain (RNApRNAbd); and (ii) an effector domain, wherein the effector domain is capable of adding or removing a methyl group in an RNA. The disclosed RNA methylation editor constructs are capable of achieving limited off-target modifications in RNA molecules. Further, the disclosure provides methods for making and using the programmable methylation editors to modifying the methylation state of RNA. The disclosure further provides complexes comprising a methylation writer protein and a guide RNA molecule and complexes comprising a demethylation eraser protein and a guide RNA molecule. The disclosure further provides pharmaceutical compositions and cells comprising the disclosed fusion proteins and complexes. |
| FILED | Tuesday, July 09, 2019 |
| APPL NO | 17/259147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 2319/09 (20130101) C07K 2319/095 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/0071 (20130101) C12N 9/1007 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 114/11 (20130101) C12Y 201/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033794 | Batlle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Batlle (Chicago, Illinois); Jan Wysocki (Chicago, Illinois) |
| ABSTRACT | Disclosed are variants of ACE2, pharmaceutical compositions comprising the variants of ACE2, and treatment methods for reducing Angiotensin II (1-8) plasma levels and/or increasing Angiotensin (1-7) plasma levels in a subject in need thereof. The disclosed variants of ACE2 may include polypeptide fragments of ACE2 having ACE2 activity for converting AngII(1-8) to Ang(1-7). Suitable subjects suitable for the disclosed methods of treatment may include subjects having or at risk for developing diabetic and non-diabetic chronic kidney disease, acute renal failure and its prevention, chronic kidney disease, severe hypertension, scleroderma and its skin, pulmonary, kidney and hypertensive complications, malignant hypertension, renovascular hypertension secondary to renal artery stenosis, idiopathic pulmonary fibrosis, liver fibrosis such as in liver cirrhosis patients, an aortic aneurysm, cardiac fibrosis and remodeling, left ventricular hypertrophy, and an acute stroke. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/391680 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/4813 (20130101) A61K 47/60 (20170801) A61K 47/68 (20170801) A61K 47/6929 (20170801) Peptides C07K 14/315 (20130101) C07K 14/765 (20130101) C07K 2319/21 (20130101) C07K 2319/30 (20130101) C07K 2319/31 (20130101) C07K 2319/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) Original (OR) Class Enzymes C12Y 304/17023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033804 | Garcia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia); The Regents of the University of Michigan (Ann Arbor, Michigan); Bolder BioTechnology, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andres J. Garcia (Atlanta, Georgia); George N. Cox (Louisville, Colorado); Jose Garcia (Atlanta, Georgia); Asma Nusrat (Ann Arbor, Michigan); Miguel Angel Quiros Quesada (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are methods and compositions for enhancement of stem-cell based immunomodulation and promotion of tissue repair. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390190 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) C12N 15/1044 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033805 | Srivatsan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanjay SRIVATSAN (Seatle, Washington); Jose MCFALINE-FIGUEROA (Seatle, Washington); Vijay RAMANI (Seatle, Washington); Junyue CAO (Seatle, Washington); Gregory BOOTH (Seatle, Washington); Jay SHENDURE (Seatle, Washington); Cole TRAPNELL (Seatle, Washington); Frank STEEMERS (San Diego, California); ILLUMINA, INC. (San Diego, California); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanjay Srivatsan (Seattle, Washington); Jose McFaline-Figueroa (Seattle, Washington); Vijay Ramani (Seattle, Washington); Junyue Cao (Seattle, Washington); Gregory Booth (Seattle, Washington); Jay Shendure (Seattle, Washington); Cole Trapnell (Seattle, Washington); Frank J. Steemers (San Diego, California) |
| ABSTRACT | Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the method includes nuclear or cellular hashing which permits increased sample throughput and increased doublet detection at high collision rates. In one embodiment, the method includes normalization hashing which aids in estimating and removing technical noise in cell to cell variation and increases sensitivity and specificity. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 17/276667 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033819 | Brar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jaan Biotherapeutics LLC (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bhawanjit Kaur Brar (La Jolla, California); Eric G. Marcusson (San Francisco, California) |
| ABSTRACT | Disclosed herein include microRNA antagonists, therapeutic compositions that include one or more of such microRNA antagonists, and methods of treating and/or ameliorating cardiac diseases and/or muscular dystrophy disorders with the microRNA antagonists. Also included are combination therapies, wherein a therapeutic composition disclosed herein and an additional therapy agent are provided to a subject having or suspected of having cardiac disease and/or muscular dystrophy disorder. In particular, some embodiments disclosed herein relate to compositions and methods for transiently administering a mixture of microRNA antagonists for promoting cardiomyocyte proliferation and cardiac regeneration. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397713 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/113 (20130101) C12N 2310/141 (20130101) C12N 2310/315 (20130101) C12N 2310/344 (20130101) C12N 2310/346 (20130101) C12N 2310/3231 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033826 | Hauswirth et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | William W. Hauswirth (Gainesville, Florida); Alfred S. Lewin (Gainesville, Florida); Cristhian J. Ildefonso (Gainesville, Florida); Brianna M. Young (Ocklawaha, Florida) |
| ABSTRACT | Aspects of the disclosure relate to methods and compositions useful for treating bestrophinopathies, such as Best Disease. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 17/272203 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Peptides C07K 14/705 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/531 (20130101) C12N 2320/30 (20130101) C12N 2750/14143 (20130101) C12N 2800/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033830 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Boston University (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Trustees of Boston University (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Timothy Kuan-Ta Lu (Cambridge, Massachusetts); Robert James Citorik (Somerville, Massachusetts); James Collins (Newton, Massachusetts); Russell-John Krom (Boston, Massachusetts) |
| ABSTRACT | Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/189113 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/70 (20130101) C12N 15/74 (20130101) Original (OR) Class C12N 2795/14132 (20130101) C12N 2795/14143 (20130101) C12N 2795/14171 (20130101) C12N 2830/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033850 | RAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Catholic University of America (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venigalla B. RAO (Washington, District of Columbia); Jingen ZHU (Washington, District of Columbia) |
| ABSTRACT | Described is an “artificial virus” (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/359711 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2795/00043 (20130101) C12N 2795/00051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033889 | Straus |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | First Light Diagnostics, Inc. (Chelmsford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Don Straus (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides a version of fluorescent in situ hybridization (FISH) in which all the steps are performed at physiological temperatures, i.e., body temperature, to detect and identify pathogenic bacteria in clinical samples. Methods of the invention use species-specific fluorescent probes to label clinically important infectious bacteria. A sample such as a urine sample is loaded into a cartridge, fluorescently labeled, and imaged with a microscope. Labelled bacteria are pulled down onto an imaging surface and a dye cushion is used to keep unbound probes off of the imaging surface. A microscopic image of the surface shows whether and in what quantities the infectious bacteria are present in the clinical sample. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/282630 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/20 (20130101) C12Q 1/689 (20130101) C12Q 1/6841 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54333 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033890 | HE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Chuan HE (Chicago, Illinois); Boxuan Simen ZHAO (Chicago, Illinois); Pradnya NARKHEDE (Chicago, Illinois); Chang LIU (Chicago, Illinois); Xiaolong CUI (Chicago, Illinois) |
| ABSTRACT | Methods, compositions and kits are provided to amplify the amount of genomic methylated DNA can by subsequently analyzed and/or sequenced. It has particular use with small amounts of DNA, including, but not limited to cell free DNA samples. In some embodiments, the ratio of polymerase and methyltransferase is controlled in order to provide maximum yields. In some embodiments, a dual primase/polymerase is used. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/448958 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6844 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033893 | Lan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Freeman Lan (San Francisco, California); Benjamin Demaree (Berkeley, California); Iain Clark (San Francisco, California); Adam R. Abate (Daly City, California) |
| ABSTRACT | The present disclosure provides ultrahigh-throughput single cell genomic sequencing methods, referred to herein as “SiC-seq”, which methods include encapsulating single cells in molten gel droplets to facilitate bulk cell lysis and purification of genomic DNA in microgels. Systems and devices for practicing the subject methods are also provided. |
| FILED | Thursday, December 21, 2017 |
| APPL NO | 16/468652 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1044 (20130101) C12N 15/1068 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033908 | RABINOWITZ et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Natera, Inc. (San Carlos, California) |
| ASSIGNEE(S) | Natera, Inc. (San Carlos, California) |
| INVENTOR(S) | Matthew RABINOWITZ (San Francisco, California); Milena BANJEVIC (Los Altos Hills, California); Zachary DEMKO (San Francisco, California); David JOHNSON (San Francisco, California); Dusan KIJACIC (Los Altos Hills, California); Dimitri PETROV (Stanford, California); Joshua SWEETKIND-SINGER (San Jose, California); Jing XU (Jersey City, New Jersey) |
| ABSTRACT | Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/503182 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) C12Q 1/6869 (20130101) C12Q 1/6876 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2537/149 (20130101) C12Q 2545/114 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 25/00 (20190201) G16B 30/00 (20190201) G16B 40/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033910 | Ting et al. |
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| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David T. Ting (Dover, Massachusetts); Irun Bhan (Brookline, Massachusetts); Kelly Mosesso (Boston, Massachusetts); Martin Aryee (Cambridge, Massachusetts) |
| ABSTRACT | The present invention relates to methods for diagnosing, determining, or monitoring liver diseases and conditions based on the blood concentration of circulating epithelial cells in and their gene expression. |
| FILED | Wednesday, September 11, 2019 |
| APPL NO | 17/274955 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/112 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/34 (20130101) G01N 33/582 (20130101) G01N 33/5005 (20130101) G01N 33/6893 (20130101) G01N 2800/52 (20130101) G01N 2800/56 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033914 | Nikiforov et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yuri E. Nikiforov (, None); UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuri E. Nikiforov (Pittsburgh, Pennsylvania); Marina N. Nikiforova (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure provides systems and methods for the highly sensitive and effective treatment and diagnosis of cancer. The methods disclosed herein take advantage of the discovery of a series of newly identified, inter-chromosomal genetic fusion events that occur upstream from the IGF2BP3 gene, which result in elevated expression of IGF2BP3 protein. The present disclosure utilizes biomarkers developed using this set of newly discovered genetic fusion events and elevated expression of IGF2BP3 protein to not only diagnosis cancer with high sensitivity and reliability, but also to pre-select patient populations that are expected to display an elevated likelihood of success when treated with any of numerous inhibitors of IGF1R-mediated signaling. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/346540 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) G01N 33/57407 (20130101) G01N 33/57419 (20130101) G01N 33/57423 (20130101) G01N 33/57438 (20130101) G01N 33/57449 (20130101) G01N 33/57496 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034715 | RAM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rajeev J. RAM (Arlington, Massachusetts); Amir H. Atabaki (San Francisco, California); Nili Persits (Cambridge, Massachusetts); Jaehwan Kim (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rajeev J. RAM (Arlington, Massachusetts); Amir H. Atabaki (San Francisco, California); Nili Persits (Cambridge, Massachusetts); Jaehwan Kim (Cambridge, Massachusetts) |
| ABSTRACT | Swept-source Raman spectroscopy uses a tunable laser and a fixed-wavelength detector instead of a spectrometer or interferometer to perform Raman spectroscopy with the throughput advantage of Fourier transform Raman spectroscopy without bulky optics or moving mirrors. Although the tunable laser can be larger and more costly than a fixed wavelength diode laser used in other Raman systems, it is possible to split and switch the laser light to multiple ports simultaneously and/or sequentially. Each site can be monitored by its own fixed-wavelength detector. This architecture can be scaled by cascading fiber switches and/or couplers between the tunable laser and measurement sites. By multiplexing measurements at different sites, it is possible to monitor many sites at once. Moreover, each site can be meters to kilometers from the tunable laser. This makes it possible to perform swept-source Raman spectroscopy at many points across a continuous flow manufacturing environment with a single laser. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335299 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/0218 (20130101) Original (OR) Class G01J 3/4412 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) G01N 2201/06113 (20130101) Optical Elements, Systems, or Apparatus G02B 6/4206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034780 | SWAMI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nathan SWAMI (Charlottesville, Virginia); John MCGRATH (Charlottesville, Virginia); Walter VARHUE (Glen Allen, Virginia); Carlos HONRADO (Charlottesville, Virginia); Vahid FARMEHINI (Charlottesville, Virginia); Yi LIU (Charlottesville, Virginia); UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan SWAMI (Charlottesville, Virginia); John MCGRATH (Charlottesville, Virginia); Walter VARHUE (Glen Allen, Virginia); Carlos HONRADO (Charlottesville, Virginia); Vahid FARMEHINI (Charlottesville, Virginia); Yi LIU (Charlottesville, Virginia) |
| ABSTRACT | An exemplary method and system is disclosed that facilitate the integration of multiplexed single-cell impedance cytometry in a high throughput format, which can be deployed upstream from microfluidic sample preparation and/or downstream to microfluidic cell separation. In exemplary method and system may employ impedance-based quantification of cell electrophysiology on the same microfluidic chip (i.e., “on-chip”) to provide distinguishing phenotypic information on the sample, without the need for additional sample handling, preparation or dilution steps as would be needed for other flow cytometry techniques. |
| FILED | Thursday, September 26, 2019 |
| APPL NO | 17/280480 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/10 (20130101) B01L 2200/027 (20130101) B01L 2200/0652 (20130101) B01L 2300/0645 (20130101) B01L 2400/0424 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) G01N 15/1056 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034785 | LO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu-Hwa LO (San Diego, California); Yi Gu (La Jolla, California) |
| ABSTRACT | A cell sorting system is provided to comprise: an imaging device including abeam scanner scanning abeam along a first direction to obtain a cell image data including fluorescent information or cell image information of a cell, the beam applied to the cell flowing in a channel along a second direction with an angle to the first direction; a data processing and control device in communication with the imaging device, the data processing and control device including a processor configured to process the cell image data obtained by the imaging device to determine one or more properties associated with the cell from the processed cell image data and to produce a control command based on a comparison of the determined one or more properties with a sorting criteria, and a cell sorting device in communication with the imaging device and the data processing and control device. |
| FILED | Monday, September 16, 2019 |
| APPL NO | 17/275994 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 47/04 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/147 (20130101) G01N 15/1436 (20130101) G01N 15/1475 (20130101) Original (OR) Class G01N 2015/1006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034869 | Blainey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Paul Blainey (Cambridge, Massachusetts); Dwayne Vickers (San Diego, California); Nir Hacohen (Brookline, Massachusetts) |
| ABSTRACT | A system and method for isolating target substrates includes a microfluidic chip, comprising a plurality of processing units, each processing unit comprising: an inlet port, a plurality of first chambers connected to the inlet port by a fluid channel, the fluid channel comprising a plurality of valves, a plurality of second chambers, each of the second chambers connected to a respective first chamber by a fluid channel, each fluid channel including a controllable blocking valve, and a plurality of respective outlet ports, each outlet port in fluid communication with a respective one of said second chambers and each outlet port including a blocking valve. A magnet is adjacent the microfluidic chip and is movable relative to the microfluidic chip. A valve control is capable of actuating certain ones of the controllable blocking valves in response to a control signal. |
| FILED | Friday, January 29, 2021 |
| APPL NO | 17/163054 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) B01L 2300/0861 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/536 (20130101) G01N 33/543 (20130101) G01N 33/587 (20130101) G01N 33/5044 (20130101) Original (OR) Class G01N 33/54326 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034870 | Boehm et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jesse Boehm (Cambridge, Massachusetts); Yuen-Yi Tseng (Cambridge, Massachusetts) |
| ABSTRACT | Described in certain embodiments herein are combinatorial addressable arrays configured for high-throughput analysis of a sample and methods of using said combinatorial addressable arrays. Also described herein in certain embodiments are computer-implemented methods of training a statistical or machine learning model for determining and/or predicting culture conditions effective for growth of a biologic sample and computer-implemented method to determine and/or predict culture conditions effective growth for growth of a biologic sample. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387548 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034887 | Zayed et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mohamed Zayed (St. Louis, Missouri); Clay Semenkovich (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Mohamed Zayed (St. Louis, Missouri); Clay Semenkovich (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of a method of detection, treatment, and monitoring of cardiovascular disease or a foot wound by detection of a novel biomarker, Fatty Acid Synthase (FAS). Briefly, therefore, the present disclosure is directed to methods that allow for improved, noninvasive, and reliable diagnosis of these conditions, particularly in subjects suffering from Type 2 Diabetes (T2D). |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501059 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 33/573 (20130101) Original (OR) Class G01N 2333/91057 (20130101) G01N 2800/32 (20130101) G01N 2800/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034901 | Prasad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington); Washington State University (Pullman, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington); Washington State University (Pullman, Washington) |
| INVENTOR(S) | Bhagwat Prasad (Seattle, Washington); Kenneth E. Thummel (Seattle, Washington); Abdul Basit Shaikh (Seattle, Washington); Allan E. Rettie (Seattle, Washington) |
| ABSTRACT | Methods of LC-MS/MS quantification of γ-carboxylated proteins in plasma, serum, or blood, including dried blood spots, are disclosed. The methods can be used to determine patient-specific dosing of anticoagulant drugs and diagnosis of liver diseases, such as hepatocellular carcinoma. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/386234 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034903 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Schepens Eye Research Institute, Inc. (Boston, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dong Feng Chen (Newtonville, Massachusetts); Jianzhu Chen (Lexington, Massachusetts); Huihui Chen (Hunan, China PRC) |
| ABSTRACT | The present invention comprises a composition with means to inhibit an autoimmune response and methods for using this composition to treat glaucoma and optic neuropathy. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/451194 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 9/0051 (20130101) A61K 31/382 (20130101) A61K 31/433 (20130101) A61K 31/436 (20130101) A61K 31/683 (20130101) A61K 31/4168 (20130101) A61K 31/4178 (20130101) A61K 31/4704 (20130101) A61K 31/5377 (20130101) A61K 31/5575 (20130101) A61K 38/13 (20130101) A61K 38/21 (20130101) A61K 38/1793 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/2809 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 33/6893 (20130101) G01N 33/56972 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034913 | Wang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (CLEVELAND, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xinglong Wang (Cleveland, Ohio) |
| ABSTRACT | A method of identifying a subject at risk of a disease or disorder associated with amyloid aggregation includes assaying for Aggregatin in a bodily sample obtained from the subject, wherein the subject is at risk of having the disease or disorder if the Aggregatin is present above a threshold level. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 17/435516 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/4709 (20130101) G01N 2800/2821 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034915 | Everson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Thomas Everson (Englewood, Colorado); Steve Mark Helmke (Denver, Colorado) |
| ABSTRACT | A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/504788 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/575 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) Original (OR) Class G01N 2800/085 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034986 | Dosenbach et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri); Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nico Dosenbach (St. Louis, Missouri); Jonathan Koller (St. Louis, Missouri); Andrew Van (St. Louis, Missouri); Abraham Snyder (St. Louis, Missouri); Amy Mirro (St. Louis, Missouri); Damien Fair (, None); Eric Earl (, None); Rachel Klein (, None); Oscar Miranda Dominguez (, None); Anders Perrone (, None) |
| ABSTRACT | Methods, computer-readable storage devices, and systems are described for reducing movement of a patient undergoing a magnetic resonance imaging (MRI) scan by aligning MRI data, the method implemented on a Framewise Integrated Real-time MRI Monitoring (“FIRMM”) computing device including at least one processor in communication with at least one memory device. Aspects of the method comprise receiving a data frame from the MRI system, aligning the received data frame to a preceding data frame, calculating motion of a body part between the received data frame and the preceding data frame, calculating total frame displacement, and excluding data frames with a cutoff above a pre-identified threshold of the total frame displacement. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/451539 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0041 (20130101) G01R 33/4831 (20130101) G01R 33/5608 (20130101) G01R 33/56509 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220036546 | Muller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marie Muller (Raleigh, North Carolina); Thomas Egan (Raleigh, North Carolina); Kaustav Mohanty (Raleigh, North Carolina) |
| ABSTRACT | An ultrasound system and method are provided for detecting lesions and/or abnormalities in a heterogeneous medium. An array of ultrasound transducer elements configured to emit ultrasound signals and to receive backscattered ultrasound signals. A processor performs a lesion detection algorithm that processes the backscattered ultrasound signals to obtain an Inter-element Response Matrix (IRM), splits the IRM into a plurality of sub-IRMs corresponding to subsets of the ultrasound transducer elements, and then performs additional processing that includes performing a depression detection algorithm to identify one or more lesions and/or abnormalities. |
| FILED | Tuesday, December 03, 2019 |
| APPL NO | 17/299676 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/08 (20130101) A61B 8/4488 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 7/136 (20170101) G06T 2207/10132 (20130101) G06T 2207/20024 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220030869 | LYNN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David M. LYNN (Middleton, Wisconsin); Harshit AGARWAL (Madison, Wisconsin) |
| ABSTRACT | The present invention provides materials and methods of making materials, where at least one surface of the material utilizes an emulsion to controllably release active agents, which can include hydrophilic agents, into the surrounding environment. Preferably, the materials are ‘slippery’ in that liquid droplets and other compounds, such as aqueous fluids, organic compounds and microorganisms, are able to easily slide off the surface without adhering to the surface. The active agents released by the emulsion may include antimicrobial agents, antifungal agents, antibacterial agents and other molecules that can kill or otherwise reduce the number of the pathogens. The resulting materials have improved anti-fouling behaviors compared to many other existing types of anti-fouling surfaces. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390568 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/04 (20130101) A01N 25/10 (20130101) A01N 43/08 (20130101) A01N 43/52 (20130101) Original (OR) Class Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220030985 | VISELL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yon VISELL (Santa Barbara, California); Elliot HAWKES (Goleta, California); Do Thanh NHO (Goleta, California); Mengjia ZHU (Goleta, California) |
| ABSTRACT | A selectively actuated textile includes one or more pieces of fabric having one or more circumferentially constrained channels and one or more hollow elastic tubes located within the circumferentially constrained channels and configured to receive a working fluid. Selectively providing or removing working fluid from the hollow elastic tubes provides for selective actuation of the textile. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/275731 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 1/002 (20130101) A41D 19/0024 (20130101) Original (OR) Class Characteristic Features of Footwear; Parts of Footwear A43B 3/0005 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 6/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031187 | MATTHEWS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cardiac Motion, LLC (Sacramento, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis MATTHEWS (Truckee, California); Xiaoguang LIU (Davis, California); Sonjie BI (Davis, California) |
| ABSTRACT | The present disclosure describes a method and device to monitor the heart of a subject using radio signals. Availability of a portable heart monitor that can be used in a subject's home can increase patient compliance and improve diagnosis rates of cardiac conditions. A mobile heart monitor can be especially useful to those subjects who are elderly, incapacitated, or do not have easy access to a clinic, doctor's office, or hospital. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399140 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/024 (20130101) A61B 5/361 (20210101) A61B 5/0507 (20130101) Original (OR) Class A61B 5/7282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031347 | Seymour et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brigham Young University (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kendall H. Seymour (Springville, Utah); Jacob Sheffield (Provo, Utah); Lance Hyatt (Provo, Utah); Scott Cunnington (Provo, Utah); Spencer P. Magleby (Provo, Utah); Larry L. Howell (Orem, Utah) |
| ABSTRACT | A hollow rod developable actuator tool including a first link comprising an outer cylinder, a second link comprising a first tool member pivotably connected to the first link at a first joint mounted in a first cavity in the wall of the outer cylinder, a third link comprising a second tool member pivotably connected to the first tool member at a second link, and a fourth link comprising an inner cylinder to which the second tool member is also pivotably connected at a third link mounted in a second cavity in the wall of the inner cylinder. When the inner cylinder of the fourth link is rotated in relation to the outer cylinder of the first link the actuator tool transitions from a first state where the tool is closed to a second state where the tool is open. |
| FILED | Wednesday, September 18, 2019 |
| APPL NO | 17/277010 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/32002 (20130101) Original (OR) Class A61B 2017/32004 (20130101) A61B 2017/320032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031617 | Fahmy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tarek M. Fahmy (New Haven, Connecticut); Eric Stern (Jamaica Plain, Massachusetts); Richard A. Flavell (Guillford, Connecticut); Jason Park (New York, New York); Alyssa Siefert (Naugatuck, Connecticut); Stephen H. Wrzesinski (Slingerlands, New York) |
| ABSTRACT | A “nanolipogel” is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can be constructed so as to incorporate a variety of different chemical entities that can subsequently be released in a controlled fashion. These different incorporated chemical entities can differ dramatically with respect to size and composition. Nanolipogels have been constructed to contain co-encapsulated proteins as well as small hydrophobic drugs within the interior of the lipid bilayer. Agents incorporated within nanolipogels can be released into the milieu in a controlled fashion, for example, nanolipogels provide a means of achieving simultaneous sustained release of agents that differ widely in chemical composition and molecular weight. Additionally, nanolipogels can favorably modulate biodistribution. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399544 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) Original (OR) Class A61K 9/1271 (20130101) A61K 9/1273 (20130101) A61K 9/1277 (20130101) A61K 9/5153 (20130101) A61K 31/343 (20130101) A61K 38/1841 (20130101) A61K 38/2013 (20130101) A61K 47/24 (20130101) A61K 47/40 (20130101) A61K 47/58 (20170801) A61K 47/6849 (20170801) A61K 47/6937 (20170801) A61K 47/6951 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 16/2812 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031661 | RIVERA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF KANSAS (Lawrence, Kansas); OKLAHOMA STATE UNIVERSITY (Stillwater, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mario RIVERA (Baton Rouge, Louisiana); Huili YAO (Baton Rouge, Louisiana); Richard A. BUNCE (Stillwater, Oklahoma); Baskar NAMMALWAR (San Diego, California); Krishna Kumar GNANASEKARAN (Mississauga, Canada); Kate ESHELMAN (Alexandria, Virginia); Achala N.D. PUNCHI HEWAGE (Lawrence, Kansas); Scott LOVELL (Shawnee, Kansas) |
| ABSTRACT | The present technology provides compounds of Formula I and related methods for treating a bacterial infection as well as methods for inhibiting interaction of a bacterioferritin and a bacterioferritin-associated ferredoxin. |
| FILED | Tuesday, December 03, 2019 |
| APPL NO | 17/299267 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/454 (20130101) A61K 31/496 (20130101) A61K 31/502 (20130101) A61K 31/4035 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 209/48 (20130101) C07D 237/32 (20130101) C07D 401/12 (20130101) C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032119 | Adamczyk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Gabriel Adamczyk (Madison, Wisconsin); Alexander Raymond Dawson-Elli (Madison, Wisconsin) |
| ABSTRACT | Aspects of the present disclosure are directed toward apparatuses and methods for rendering haptic environments, such as may be used in rehabilitation. As may be implemented in accordance with one or more embodiments, haptic rehabilitative movement is effected by providing feedback signals characterizing sensed engagement of a user's lower extremity with a crank coupled to a shaft that is driven by a motor, and controlling movement of the crank in response to the feedback signals. Force may be provided by the motor and shaft, by applying control inputs to the motor that cause the motor and crank to render respective haptic environments while engaged with the user's lower extremity, via rotation of the shaft. The haptic environments may include one or both of impedance-based haptic environments and admittance-based haptic environments. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/393197 |
| CURRENT CPC | Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 22/0605 (20130101) Original (OR) Class A63B 24/0062 (20130101) A63B 24/0075 (20130101) A63B 24/0087 (20130101) A63B 2022/0611 (20130101) A63B 2022/0652 (20130101) A63B 2220/30 (20130101) A63B 2220/51 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032290 | Sun et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gongchen Sun (Atlanta, Georgia); Hang Lu (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a fluidic device comprising a substrate, an applicator, and a spacer. The substrate can comprise a plurality of wells. The applicator can be used for manipulating a biological substance in at least a portion of the plurality of wells. The spacer can be positioned between the substrate and the applicator. The spacer can be configured to allow the applicator to apply the biological substance to at least a portion of the plurality of wells while maintaining a space between the substrate and the applicator. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499515 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5085 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2200/0642 (20130101) B01L 2300/161 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032338 | LYNN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David M. LYNN (Middleton, Wisconsin); Harshit AGARWAL (Madison, Wisconsin) |
| ABSTRACT | This invention discloses spray-based methods for generating polymer-based coatings with a range of morphologies, chemical reactivities, and physical stabilities useful for a broad range of applications, such as for the fabrication of non-wetting and slippery surfaces. Certain embodiments of this invention provide coatings with nanoscale morphologies, physical stabilities, and chemical reactivities that are similar to or improved compared to analogous coatings and materials made using conventional dip coating or flow-based methods. These spray-based methods can also be used to fabricate coatings with substantially similar functional properties, but with improved consistency, efficiency, additional functionality, and reproducibility. In an aspect of the invention, two or more chemically reactive polymer solutions are sprayed onto a substrate to form a crosslinked polymer coating on the substrate. The polymer solutions may be applied to the substrate sequentially or simultaneously. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390559 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/02 (20130101) Original (OR) Class B05D 3/105 (20130101) B05D 3/108 (20130101) B05D 5/00 (20130101) B05D 7/5485 (20130101) B05D 2401/10 (20130101) B05D 2401/21 (20130101) B05D 2518/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/63 (20180101) C09D 7/67 (20180101) C09D 137/00 (20130101) C09D 179/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032350 | SAMBROTTO |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond SAMBROTTO (Blauvelt, New York) |
| ABSTRACT | Systems and methods for performing bioremediation using the Geobacillus sp. bacterial strain are provided which are capable of effectively degrading Benzo[a]pyrene (BaP) and efficiently degrading other ring-based organic contaminants. The exemplary bioremediation methods include steps for administering an effective, degrading amount of the bacteria to soil containing excess amounts of BaP and incubating the bacteria administered to the soil at a given temperature and for a duration that are suitable for promoting incubation and reducing and the concentration of BaP below a maximum concentration, as might be specified by a regulatory body. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502595 |
| CURRENT CPC | Reclamation of Contaminated Soil B09C 1/06 (20130101) B09C 1/10 (20130101) Original (OR) Class Treatment of Water, Waste Water, Sewage, or Sludge C02F 3/34 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/01 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032442 | Sheffield et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brigham Young University (Provo, Utah) |
| ASSIGNEE(S) | Brigham Young University (Provo, Utah) |
| INVENTOR(S) | Jacob Sheffield (Provo, Utah); Kendall Hal Seymour (Springville, Utah); Lance Hyatt (Provo, Utah); Scott Cunnington (Provo, Utah); Spencer Magleby (Provo, Utah); Larry L. Howell (Orem, Utah); Robert Lang (Alamo, California) |
| ABSTRACT | A hollow rod developable actuator tool including a first link comprising an outer cylinder, a deployment ring including second link comprising a first portion pivotably connected to the first link at a first joint mounted in a first cavity in the wall of the outer cylinder and a third link comprising a second tool portion pivotably connected to the first portion at a second link, and a fourth link comprising an inner cylinder to which the second portion of the deployment ring is also pivotably connected at a third link mounted in a second cavity in the wall of the inner cylinder. When the inner cylinder of the fourth link is rotated in relation to the outer cylinder of the first link the actuator tool transitions from a first state where the deployment ring is stowed within the tool to a second state where the deployment ring is deployed externally. |
| FILED | Wednesday, September 18, 2019 |
| APPL NO | 17/277026 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) Handles for Hand Implements B25G 1/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032458 | CHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Diligent Robotics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Diligent Robotics, Inc. (Austin, Texas) |
| INVENTOR(S) | Vivian Yaw-Wen CHU (Austin, Texas); Shuai LI (Sammamish, Washington); Forrest GREEN (Austin, Texas); Peter WORSNOP (Bethesda, Maryland); Andrea Lockerd THOMAZ (Austin, Texas) |
| ABSTRACT | Systems, apparatus, and methods are described for robotic learning and execution of skills. A robotic apparatus can include a memory, a processor, sensors, and one or more movable components (e.g., a manipulating element and/or a transport element). The processor can be operatively coupled to the memory, the movable elements, and the sensors, and configured to obtain information of an environment, including one or more objects located within the environment. In some embodiments, the processor can be configured to learn skills through demonstration, exploration, user inputs, etc. In some embodiments, the processor can be configured to execute skills and/or arbitrate between different behaviors and/or actions. In some embodiments, the processor can be configured to learn an environmental constraint. In some embodiments, the processor can be configured to learn using a general model of a skill. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504130 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 5/00 (20130101) B25J 9/06 (20130101) B25J 9/0081 (20130101) B25J 9/163 (20130101) B25J 9/1661 (20130101) Original (OR) Class B25J 9/1694 (20130101) B25J 11/0005 (20130101) B25J 15/00 (20130101) B25J 19/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032485 | Hyatt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Brigham Young University (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lance Hyatt (Provo, Utah); Jacob Sheffield (Provo, Utah); Kendall Hal Seymour (Springville, Utah); Scott Cunnington (Provo, Utah); Spencer Magleby (Provo, Utah); Larry L. Howell (Orem, Utah) |
| ABSTRACT | A hollow rod developable actuator tool including a cylinder defining the outer circumference of the hollow rod, a first tool mechanism, and a second tool mechanism. The hollow rod developable actuator tool transitions from a first closed state wherein the first tool mechanism and second tool mechanism are contained entirely within the outer circumference of the hollow rod to a second open state wherein the first tool mechanism and second tool mechanism extent outside the outer circumference of the hollow rod. |
| FILED | Wednesday, September 18, 2019 |
| APPL NO | 17/277014 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/295 (20130101) Hand-held Cutting Tools Not Otherwise Provided for B26B 27/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033341 | ABU-OMAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SPERO RENEWABLES, LLC (Goleta, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mahdi M. ABU-OMAR (Goleta, California); Daniel H. COLLER (Goleta, California); Ian M. KLEIN (Goleta, California) |
| ABSTRACT | A process for a reactive separation of organic molecules from biomass includes a reaction step for the biomass, a simultaneous extraction step using a solvent, and a filtration step to recover products, wherein the products comprise ferulic acid and/or coumaric acid. The products are extracted from the biomass in a pressurized stirred batch reactor using a liquid extraction solvent and a base in which the ferulate and the coumarate remain. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/481563 |
| CURRENT CPC | Separation B01D 11/028 (20130101) B01D 11/0288 (20130101) B01D 11/0292 (20130101) B01D 15/08 (20130101) Acyclic or Carbocyclic Compounds C07C 51/09 (20130101) C07C 51/47 (20130101) C07C 51/48 (20130101) C07C 67/56 (20130101) Original (OR) Class C07C 67/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033451 | Bondos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BONDWELL TECHNOLOGIES LP (College Station, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah E. Bondos (College Station, Texas); Alexandra M. Whiteley (Houston, Texas); Kathleen S. Matthews (Houston, Texas); Zhao Huang (Houston, Texas); Autumn Brawley (College Station, Texas); Jan Patterson (College Station, Texas) |
| ABSTRACT | The present disclosure relates, in some embodiments, to a composition comprising a biomaterial. A biomaterial may comprise, for example, one or more molecules capable of self-association and/or self-assembly. In some embodiments, a biomaterial may comprise one or more polypeptides and/or proteins. A biomaterial may comprise, for example, two or more self-assembled Ultrabithorax (Ubx) protein molecules. A Ubx protein, in some embodiments, may be any wild type Drosophila melanogaster Ultrabithorax protein, including any natural or non-natural isoforms (e.g., alternative splicing isoforms). The present disclosure relates, in some embodiments, to a method of making a biomaterial comprising contacting two or more Ubx protein molecules under conditions that permit self-assembly to form a first fibril and contacting the first fibril to a second fibril. |
| FILED | Wednesday, June 09, 2021 |
| APPL NO | 17/343380 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033574 | MILLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen A. MILLER (Gainesville, Florida); Olivier NSENGIYUMVA (Washington, District of Columbia) |
| ABSTRACT | In one aspect, the disclosure relates to biorenewable polyesters and polyester copolymers derived from camphoric acid, methods of making same, and articles comprising same. The disclosed biorenewable polyesters can have a Mn of from about 5,000 Da to about 500,000 Da. Also disclosed herein is the preparation of various monomers useful in the reactions disclosed herein, e.g., cis-1,4-anhydroerythritol and bis(2-hydroxyethyl) camphorate. In various aspects, the disclosed biorenewable polyesters and polyester copolymers can be used to the production of various articles utilizing a conventional polyester or polyester copolymer, that is, to replace, in part or in whole, a conventional nonbiorenewable polyester or polyester copolymer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/414173 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 67/08 (20130101) Heterocyclic Compounds C07D 307/20 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 63/199 (20130101) Original (OR) Class C08G 2230/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033729 | Kraus et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George A. Kraus (Ames, Iowa); Kyle Podolak (Ames, Iowa); Derek Lee White (Lakewood, Colorado); Sriram Sundararajan (Ames, Iowa) |
| ABSTRACT | The present invention is toward a base oil or lubricant additives, methods of using the same, lubricant compositions including the same, and methods of forming the lubricant compositions. A base oil or lubricant additive has Structure I or Structure II as described herein. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/380766 |
| CURRENT CPC | Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 129/70 (20130101) Original (OR) Class C10M 169/04 (20130101) C10M 2203/003 (20130101) C10M 2207/281 (20130101) C10M 2207/284 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2030/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033768 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico); Jacob Ongudi Agola (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico); Jacob Ongudi Agola (Albuquerque, New Mexico) |
| ABSTRACT | An encapsulated living (viable) mammalian cell, and methods of making and using that cell, are provided. |
| FILED | Tuesday, September 24, 2019 |
| APPL NO | 17/277256 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) Original (OR) Class C12N 5/0602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033785 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Christopher Gerard Wilson (Waltham, Massachusetts); Peter J. Chen (Somerville, Massachusetts) |
| ABSTRACT | The disclosure provides programmable methylation “writers” and demethylation “erasers” for editing the methylation state of RNA targets, e.g., an RNA transcriptome. In particular, the disclosure provides RNA methylation editor polynucleotide contracts and vectors comprising (i) an RNA programmable RNA binding domain (RNApRNAbd); and (ii) an effector domain, wherein the effector domain is capable of adding or removing a methyl group in an RNA. The disclosed RNA methylation editor constructs are capable of achieving limited off-target modifications in RNA molecules. Further, the disclosure provides methods for making and using the programmable methylation editors to modifying the methylation state of RNA. The disclosure further provides complexes comprising a methylation writer protein and a guide RNA molecule and complexes comprising a demethylation eraser protein and a guide RNA molecule. The disclosure further provides pharmaceutical compositions and cells comprising the disclosed fusion proteins and complexes. |
| FILED | Tuesday, July 09, 2019 |
| APPL NO | 17/259147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 2319/09 (20130101) C07K 2319/095 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/0071 (20130101) C12N 9/1007 (20130101) Original (OR) Class C12N 15/11 (20130101) C12N 2310/20 (20170501) Enzymes C12Y 114/11 (20130101) C12Y 201/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033805 | Srivatsan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Sanjay SRIVATSAN (Seatle, Washington); Jose MCFALINE-FIGUEROA (Seatle, Washington); Vijay RAMANI (Seatle, Washington); Junyue CAO (Seatle, Washington); Gregory BOOTH (Seatle, Washington); Jay SHENDURE (Seatle, Washington); Cole TRAPNELL (Seatle, Washington); Frank STEEMERS (San Diego, California); ILLUMINA, INC. (San Diego, California); UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanjay Srivatsan (Seattle, Washington); Jose McFaline-Figueroa (Seattle, Washington); Vijay Ramani (Seattle, Washington); Junyue Cao (Seattle, Washington); Gregory Booth (Seattle, Washington); Jay Shendure (Seattle, Washington); Cole Trapnell (Seattle, Washington); Frank J. Steemers (San Diego, California) |
| ABSTRACT | Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the method includes nuclear or cellular hashing which permits increased sample throughput and increased doublet detection at high collision rates. In one embodiment, the method includes normalization hashing which aids in estimating and removing technical noise in cell to cell variation and increases sensitivity and specificity. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 17/276667 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033850 | RAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Catholic University of America (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venigalla B. RAO (Washington, District of Columbia); Jingen ZHU (Washington, District of Columbia) |
| ABSTRACT | Described is an “artificial virus” (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV. |
| FILED | Monday, June 28, 2021 |
| APPL NO | 17/359711 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2795/00043 (20130101) C12N 2795/00051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033893 | Lan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Freeman Lan (San Francisco, California); Benjamin Demaree (Berkeley, California); Iain Clark (San Francisco, California); Adam R. Abate (Daly City, California) |
| ABSTRACT | The present disclosure provides ultrahigh-throughput single cell genomic sequencing methods, referred to herein as “SiC-seq”, which methods include encapsulating single cells in molten gel droplets to facilitate bulk cell lysis and purification of genomic DNA in microgels. Systems and devices for practicing the subject methods are also provided. |
| FILED | Thursday, December 21, 2017 |
| APPL NO | 16/468652 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1044 (20130101) C12N 15/1068 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033963 | MASCHMANN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MATTHEW R. MASCHMANN (COLUMBIA, Missouri); MATTHIAS J. YOUNG (COLUMBIA, Missouri) |
| ABSTRACT | The present disclosure relates to a method of depositing a nanoscale-thin film onto a substrate. The method generally comprises depositing a layer of a solid or gaseous state functionalizing molecule onto or adjacent to the first surface of the substrate and exposing the first surface to a source of ionizing radiation, thereby functionalizing the first surface of the substrate. Once the layer of functionalizing molecule is removed, a nanoscale-thin film is then deposited onto the functionalized first surface of the substrate. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387185 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/20 (20130101) C23C 16/0263 (20130101) Original (OR) Class C23C 16/403 (20130101) C23C 16/45527 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033985 | WEST et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Alan WEST (Tenafly, New Jersey); Scott BANTA (Fairfield, Connecticut); Jon VARDNER (New York, New York); Campbell DONNELLY (New York, New York); Zhengyan ZHANG (Changshu, China PRC) |
| ABSTRACT | An electrochemical system and process are provided to convert an amount of chalcopyrite (CuFeS2) to a product including copper ions. In an electrochemical reactor, a potential is applied across an anode and a cathode to convert the chalcopyrite to an intermediate, chalcocite (Cu2S). The anode is covered to prevent contact with the intermediate, thus limiting subsequent conversion of the intermediate to covellite (CuS) in favor of conversion to a material more suited to chemical oxidation, cuprite (Cu2O). For example, the anode can be covered with one or more layers of filter paper. Upon application of an oxidizing agent, the cuprite is oxidized to produce a product including copper ions. The cathode and covered anode allow for efficient and inexpensive processing. The cost of this technique is comparable to industry standards, and moreover, has a much smaller environmental footprint than heat-based copper extraction. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390087 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 15/0004 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/01 (20210101) C25B 9/47 (20210101) C25B 11/037 (20210101) C25B 11/042 (20210101) C25B 13/02 (20130101) C25B 15/081 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033995 | Schiros et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York); FASHION INSTITUTE OF TECHNOLOGY (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theanna Schiros (New York, New York); Asta Skocir (New York, New York); Aaron Nesser (New York, New York); Tessa Callaghan (New York, New York); Aleksandra Gosiewski (New York, New York); Sebastian Thomas Russell (New York, New York); Dong An (New York, New York); Romare Antrobus (New York, New York); Chris Mosher (New York, New York); Helen Lu (New York, New York) |
| ABSTRACT | An alginate-based fiber is made of a composition comprising an alginate, a cellulose and a polyol plasticizer, such as glycerol. The fiber is produced through extrusion in a curing bath containing calcium. The fiber provides excellent strength and flexibility in its unhydrated state for textile applications. The fiber can be used to produce textiles as compostable alternatives to petrochemical based polymers. |
| FILED | Thursday, December 05, 2019 |
| APPL NO | 17/299563 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 1/28 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/10 (20130101) D01F 2/28 (20130101) Original (OR) Class Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2401/063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034651 | Narasimhan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania); THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Toronto, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srinivasa Narasimhan (McDonald, Pennsylvania); Supreeth Achar (Seattle, Washington); Matthew O'Toole (Palo Alto, California); Kiriakos Neoklis Kutulakos (Toronto, Canada) |
| ABSTRACT | An energy optimized imaging system that includes a light source that has the ability to illuminate specific pixels in a scene, and a sensor that has the ability to capture light with specific pixels of its sensor matrix, temporally synchronized such that the sensor captures light only when the light source is illuminating pixels in the scene. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495000 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/2513 (20130101) Original (OR) Class G01B 11/2518 (20130101) G01B 11/2545 (20130101) Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 21/2033 (20130101) Image Data Processing or Generation, in General G06T 17/00 (20130101) Pictorial Communication, e.g Television H04N 5/30 (20130101) H04N 9/3129 (20130101) H04N 13/271 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034731 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Lu Li (Pittsburgh, Pennsylvania); H. Benjamin Brown (Pittsburgh, Pennsylvania); Michael Schwerin (Pittsburgh, Pennsylvania); Howie Choset (Pittsburgh, Pennsylvania) |
| ABSTRACT | A force sensor comprising a force sensitive resistor having a common electrode and an electrode array separated by a force sensitive resistor material. The sensor includes a preload structure, where the preload structure imparts a force on the force sensitive resistor material. The sensor may also include a signal conditioning board to read a signal from the electrode array and convert it to a digital output. |
| FILED | Monday, September 23, 2019 |
| APPL NO | 17/277382 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/22 (20130101) Original (OR) Class G01L 5/1627 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034947 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | YILU LIU (Knoxville, Tennessee); WEIKANG WANG (Knoxville, Tennessee); WENPENG YU (Knoxville, Tennessee); CHUJIE ZENG (Knoxville, Tennessee); LIN ZHU (Knoxville, Tennessee) |
| ABSTRACT | A method includes performing by a processor: receiving a plurality of synchrophasor measurements of a power system signal associated with a time interval from a plurality of phasor measurement units (PMUs), respectively, each of the plurality of synchrophasor measurements including a phase angle, frequency value, and a timestamp associated with the synchrophasor measurement; determining, for each of the plurality of PMUs, a dominant mode frequency of a forced oscillation signal component of the power system signal based on the frequency value and the phase angle; determining, for each of the plurality of PMUs, a mode angle of the forced oscillation signal component at the dominant mode frequency; and determining a geographic forced oscillation source location for a source of the forced oscillation signal component based on the plurality of mode angles associated with each of the plurality of PMUs, respectively, and geographic locations of the plurality of PMUs. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 16/947410 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 19/2513 (20130101) Original (OR) Class G01R 29/18 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220035224 | LEUENBERGER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MICHAEL N. LEUENBERGER (ORLANDO, Florida); MUHAMMAD WAQAS SHABBIR (ORLANDO, Florida) |
| ABSTRACT | An IR source may also include an electrically conductive layer defining a back contact. The IR source may also include a first dielectric layer over the electrically conductive layer, a transparent electrically conductive layer over the first dielectric layer, and a second dielectric layer over the transparent electrically conductive layer. The IR source may include a graphene layer over the second dielectric layer and having a perforated pattern, a protective layer over the graphene layer, and first and second electrically conductive contacts coupled to the graphene layer. The graphene layer may be configured to emit IR radiation when a voltage signal is applied between the first and second electrically conductive contacts. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/444087 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/292 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220035927 | LYSECKY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of th University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roman LYSECKY (Tucson, Arizona); Jerzy ROZENBLIT (Tucson, Arizona); Johannes SAMETINGER (Linz, Austria); Aakarsh RAO (Tucson, Arizona); Nadir CARREON (Tucson, Arizona) |
| ABSTRACT | A security framework for life-critical and safety-critical devices, specifically medical devices, using: a) runtime, adaptive methods that dynamically assess the risk of newly discovered vulnerabilities and threats, and b) automatic mitigation methods that reduce system risk by seamlessly reconfiguring the device to operate within different execution modes. This technology automatically isolates threats by disabling affected system components. A multi-modal software design uses adaptive software in which operational modes have monotonically decreasing cumulative risk. Formal risk models are used to model the individual risk of accessing or controlling system components and to automatically calculate the cumulative risk of software modes. The automated detection of potential threats by the system or reporting of known vulnerabilities will dynamically change the system risk. To support an accurate and fine grained adaptive risk model, novel statistical methods non-intrusively detect potential threats, isolate the threat to a specific component, and estimate the threat probability. |
| FILED | Friday, November 01, 2019 |
| APPL NO | 17/290627 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/0031 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/14276 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/362 (20130101) A61N 1/37223 (20130101) Electric Digital Data Processing G06F 21/566 (20130101) G06F 21/577 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/17 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220036150 | HASSANTABAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Shayan HASSANTABAR (Ewing, New Jersey); Zeyu WANG (Princeton, New Jersey); Niraj K. JHA (Princeton, New Jersey) |
| ABSTRACT | According to various embodiments, a method for generating a compact and accurate neural network for a dataset is disclosed. The method includes providing an initial neural network architecture; performing a dataset modification on the dataset, the dataset modification including reducing dimensionality of the dataset; performing a first compression step on the initial neural network architecture that results in a compressed neural network architecture, the first compression step including reducing a number of neurons in one or more layers of the initial neural network architecture based on a feature compression ratio determined by the reduced dimensionality of the dataset; and performing a second compression step on the compressed neural network architecture, the second compression step including one or more of iteratively growing connections, growing neurons, and pruning connections until a desired neural network architecture has been generated. |
| FILED | Friday, July 12, 2019 |
| APPL NO | 17/275949 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Original (OR) Class G06N 3/082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220036904 | TRAYNOR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick G. TRAYNOR (Gainesville, Florida); Kevin BUTLER (Gainesville, Florida); Logan E. BLUE (Gainesville, Florida); Luis VARGAS (Gainesville, Florida); Kevin S. WARREN (Gainesville, Florida); Hadi ABDULLAH (Gainesville, Florida); Cassidy GIBSON (Gainesville, Florida); Jessica Nicole ODELL (Gainesville, Florida) |
| ABSTRACT | A method is provided for identifying synthetic “deep-fake” audio samples versus organic audio samples. Methods may include: generating a model of a vocal tract using one or more organic audio samples from a user; identifying a set of bigram-feature pairs from the one or more audio samples; estimating the cross-sectional area of the vocal tract of the user when speaking the set of bigram-feature pairs; receiving a candidate audio sample; identifying bigram-feature pairs of the candidate audio sample that are in the set of bigram-feature pairs; calculating a cross-sectional area of a theoretical vocal tract of a user when speaking the identified bigram-feature pairs; and identifying the candidate audio sample as a deep-fake audio sample in response to the calculated cross-sectional area of the theoretical vocal tract of a user failing to correspond within a predetermined measure of the estimated cross sectional area of the vocal tract of the user. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/443654 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 17/06 (20130101) Original (OR) Class G10L 17/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220036974 | Xu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa); The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | University of Iowa Research Foundation (Iowa City, Iowa); The Penn State Research Foundation (University Park, Pennsylvania) |
| INVENTOR(S) | Weiyu Xu (Iowa City, Iowa); Xiaodong Wu (Iowa City, Iowa); Jirong Yi (Iowa City, Iowa); Raghu Mudumbai (Iowa City, Iowa); Myung Cho (Erie, Pennsylvania) |
| ABSTRACT | A method for pooled sample testing for a target substance using compressed sensing includes receiving a plurality of individual samples, determining a mixing matrix for a plurality of pooled sample mixtures to create by mixing portions of selected ones of the plurality of individual samples, and determining an allocation matrix for the plurality of pooled samples, wherein the allocation matrix allocations portions of each of the plurality of pooled samples for each test, performing mixing to create the plurality of pooled sample mixtures based on the mixing matrix and the allocation matrix, performing quantitative tests on the plurality of pooled sample mixtures so as to estimate an amount of the target substance contained within each of the plurality of pooled sample mixtures, and decoding results of the quantitative tests to determine quantitative estimates of amount of the target substance in each of the plurality of individual samples. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387863 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/00 (20190201) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037408 | Azoulay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Southern Mississippi (Hattiesburg, Mississippi); Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | The University of Southern Mississippi (Hattiesburg, Mississippi); Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Jason D. Azoulay (Hattiesburg, Mississippi); Jarrett Vella (New Carlisie, Ohio); Mohammed I. Vakil (Beavercreek, Ohio); Lifeng Huang (Hattiesburg, Mississippi); Naresh Eedugurala (Hattiesburg, Mississippi) |
| ABSTRACT | A photoconductive infrared detector comprising a substrate, an electrode geometry, and a layer of intrinsically conductive or photoconductive donor-acceptor conjugated polymer. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390277 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/307 (20130101) Original (OR) Class H01L 51/0003 (20130101) H01L 51/0036 (20130101) H01L 51/0043 (20130101) H01L 51/441 (20130101) H01L 51/448 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220038032 | Boamah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois); CALIFORNIA INSTITUTE OF TECHNOLOGY (PASADENA, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mavis D. Boamah (Evanston, Illinois); Franz M. Geiger (Evanston, Illinois); Thomas F. Miller, III (South Pasadena, California); Jeongmin Kim (Pasadena, California) |
| ABSTRACT | Energy harvesting devices and methods for converting the mechanical energy of a flowing ionic solution, such as rainwater or seawater, into electric energy are provided. The energy harvesting devices include an electric current generating device that includes a metal layer and an amphoteric metal oxide film disposed over a surface of the metal layer. By moving an electric double layer across the surface of the amphoteric metal oxide film, an electric current is generated in the metal layer. |
| FILED | Tuesday, September 17, 2019 |
| APPL NO | 17/276684 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/026 (20130101) Electric Machines Not Otherwise Provided for H02N 1/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220038035 | Cappelleri et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | David J. Cappelleri (West Lafayette, Indiana); Maria Guix Noguera (Barcelona, Spain); Song Zhang (West Lafayette, Indiana) |
| ABSTRACT | A microrobot is disclosed. The microrobot includes a magnet configured to provide a motive force when magnetic force of one or more electrical coils act upon the magnet, a support member coupled to the magnet, a thermo-responsive polymer member coupled to each end of the support member at a proximal end, the thermo-responsive polymer member configured to articulate when heated, wherein the thermo-responsive polymer members configured to receive light from a microrobot structured light system and convert the received light into heat. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501944 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 7/00 (20130101) B25J 9/0009 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0024 (20130101) B81B 3/0029 (20130101) B81B 2201/031 (20130101) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06 (20130101) Electric Machines Not Otherwise Provided for H02N 10/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220038374 | Koral et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yaron Koral (Cherry Hill, New Jersey); Simon Tse (Holmdel, New Jersey); Steven A. Monetti (Mountain Lakes, New Jersey); Tzuu-Yi Wang (Newtown, Pennsylvania); Jennifer L. Rexford (Princeton, New Jersey); Xiaoqi Chen (Princeton, New Jersey); Shir Landau Feibish (Princeton, New Jersey) |
| ABSTRACT | Systems, methods, and apparatuses provide a scalable framework for analyzing queuing and transient congestion in network switches. The system reports which flows contributed to the queue buildup and enables direct per-packet action in the data plane to prevent transient congestion. The system may be configured to analyze queuing in legacy network switches. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501372 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 43/16 (20130101) H04L 43/062 (20130101) H04L 47/11 (20130101) Original (OR) Class H04L 47/32 (20130101) H04L 47/125 (20130101) H04L 47/2483 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220031051 | Ross |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | First-Light USA, LLC (Seymour, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy B. Ross (Monticello, Illinois) |
| ABSTRACT | A harness system for a clip. The clip has a base portion and a pair of elongated members, the elongated members folded over the base portion, thereby defining a gap configured to receive portions of a harness. The elongated members are separated from one another by a longitudinal opening for accommodating a rib between the portions of the harness. A gate is securably engaged to a first one of the elongated members and rotatable between an open position in which the gate does not obstruct said longitudinal opening and a closed position in which said gate obstructs said longitudinal opening. The harness is fashioned from a strip of webbing secured to a base along its midline and edges. The webbing thereby forms two pockets, each sized to accommodate one of the elongated members of the clip. |
| FILED | Monday, August 03, 2020 |
| APPL NO | 16/947468 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 27/008 (20130101) Outerwear; Protective Garments; Accessories A41D 13/0007 (20130101) Travelling or Camp Equipment: Sacks or Packs Carried on the Body A45F 3/04 (20130101) A45F 5/02 (20130101) Original (OR) Class Vehicles, Vehicle Fittings, or Vehicle Parts, Not Otherwise Provided for B60R 11/00 (20130101) B60R 2011/0003 (20130101) B60R 2011/0063 (20130101) B60R 2011/0071 (20130101) Devices for Fastening or Securing Constructional Elements or Machine Parts Together, e.g Nails, Bolts, Circlips, Clamps, Clips, Wedges, Joints or Jointing F16B 1/00 (20130101) F16B 2/22 (20130101) F16B 11/006 (20130101) F16B 2001/0028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031204 | Sonkusale et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sameer Sonkusale (Lincoln, Massachusetts); Trupti Terse (Natick, Massachusetts) |
| ABSTRACT | A wearable sensor for monitoring an external bodily fluid includes a sensor thread, a wick, a substrate, and a communication interface all of which are disposed on a substrate. The wick wicks the external bodily fluid to a functionalized region of the thread. The communication interface transmits, to an external device, data indicative of what the sensor thread has measured in said external bodily fluid. The external device can then carry out real-time analysis or storage. |
| FILED | Wednesday, September 18, 2019 |
| APPL NO | 17/276970 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1477 (20130101) A61B 5/14517 (20130101) Original (OR) Class Electric Digital Data Processing G06F 1/163 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031672 | Bulterys et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Philip Bulterys (Los Angeles, California); Jeffery F. Miller (Santa Monica, California); Robert D. Damoiseaux (Beverly Hills, California); Christopher Todd French (Los Angeles, California) |
| ABSTRACT | Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) are Tier-1 select pathogens that cause highly lethal human infections with limited therapeutic options. Intercellular spread is a hallmark of Burkholderia pathogenesis and its prominent ties to virulence make it an attractive therapeutic target. We developed a high-throughput cell-based phenotypic assay and screened ˜220,000 small molecules for their ability to disrupt intercellular spread by Burkholderia thailandensis, a BSL-2 surrogate for these pathogens. 268 hits were identified, and cross-species validation found 32 hits that also disrupt intercellular spread by Bp and/or Bm. In a fulminant murine model of respiratory melioidosis, treatment with a number of these agents was significantly more effective than ceftazidime, the current drug of choice, for improving patient survival and decreasing bacterial counts in major organs. |
| FILED | Friday, October 04, 2019 |
| APPL NO | 17/279015 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031867 | Nedergaard et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maiken Nedergaard (Rochester, New York); Benjamin Plog (Rochester, New York); Humberto Mestre (Rochester, New York) |
| ABSTRACT | This invention relates to improving delivery of agents to the central nervous system. |
| FILED | Monday, September 30, 2019 |
| APPL NO | 17/280606 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0085 (20130101) A61K 45/06 (20130101) A61K 49/0058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031913 | Vegas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arturo Vegas (Belmont, Massachusetts); Joshua C. Doloff (Quincy, Massachusetts); Omid Veiseh (Bellaire, Texas); Minglin Ma (Ithaca, New York); Robert S. Langer (Newton, Massachusetts); Daniel G. Anderson (Framingham, Massachusetts) |
| ABSTRACT | Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body. |
| FILED | Thursday, July 15, 2021 |
| APPL NO | 17/377124 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/4816 (20130101) A61K 9/5036 (20130101) A61K 35/39 (20130101) A61K 47/36 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 29/085 (20130101) Original (OR) Class A61L 31/10 (20130101) A61L 33/08 (20130101) Heterocyclic Compounds C07D 487/04 (20130101) Polysaccharides; Derivatives Thereof C08B 37/0084 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 5/0677 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031976 | Greenblatt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elliot E. Greenblatt (Boston, Massachusetts); Jose G. Venegas (Swampscott, Massachusetts) |
| ABSTRACT | A system and method for providing a therapy to a subject may include a lumen configured to be coupled to a portion of a respiration passage of the subject to receive air respired by the subject. A sensor is configured to monitor the lumen and generate a signal based on the air respired by the subject. A pressure pulse delivery system is configured to deliver a pressure pulse along the lumen to the subject and a reservoir of therapeutic agent is coupled to the lumen. A processor is configured to receive the signal from the sensor, determine, from at least the signal, an exhalation period of the subject, and based on the exhalation period, cause the pressure pulse delivery system to deliver a pressure pulse to the subject. Following the pressure pulse, the processor can cause the therapeutic agent to be delivered from the reservoir. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186266 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 11/00 (20130101) A61M 11/02 (20130101) A61M 15/0091 (20130101) Original (OR) Class A61M 15/0098 (20140204) A61M 16/14 (20130101) A61M 16/0051 (20130101) A61M 16/0057 (20130101) A61M 16/0096 (20130101) A61M 2016/0027 (20130101) A61M 2202/0468 (20130101) A61M 2205/502 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032271 | GULIASHVILI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CytoSorbents Corporation (Monmouth Junction, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tamaz GULIASHVILI (Monmouth Junction, New Jersey); Maryann GRUDA (Monmouth Junction, New Jersey); Thomas GOLOBISH (Monmouth Junction, New Jersey); David JAMES (Monmouth Junction, New Jersey); Karl-Gustav RUGGEBERG (Monmouth Junction, New Jersey); Pamela O'SULLIVAN (Monmouth Junction, New Jersey); Sarah PATTERSON (Monmouth Junction, New Jersey) |
| ABSTRACT | The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions. |
| FILED | Monday, December 02, 2019 |
| APPL NO | 17/298968 |
| CURRENT CPC | Separation B01D 15/3809 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/3212 (20130101) B01J 20/3274 (20130101) Original (OR) Class B01J 20/28019 (20130101) B01J 20/28078 (20130101) Peptides C07K 1/22 (20130101) C07K 16/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032340 | Diez-Garias et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Francisco J. Diez-Garias (Bridgewater, New Jersey); Thomas E. Hansen (Newport, Rhode Island) |
| ABSTRACT | An acoustic transducer system for projecting and sensing acoustic waves or sound in fluid is disclosed in accordance with the present disclosure and figures herein. The system includes a transducer array of a plurality of channels, each channel having an inlet and an outlet, and a reservoir containing a liquid solution. A first electrode is disposed proximate to the inlet and a second electrode is disposed proximate to the outlet. A voltage source, connected to the first and second electrodes, is configured to apply voltage across a length of the array of the channels to generate an electric field parallel to each channel. The electric field causes an electroosmotic flow of ions from the reservoir to the outlet, producing a plurality of acoustic waves or sound at the outlet. A method for projecting and sensing acoustic waves or sound in fluid using the acoustic transducer system is also disclosed herein. |
| FILED | Wednesday, July 17, 2019 |
| APPL NO | 17/277056 |
| CURRENT CPC | Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/02 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/44791 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032469 | Khripin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Boston Dynamics, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | Boston Dynamics, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Alex Khripin (Waltham, Massachusetts); Stephen Berard (Waltham, Massachusetts); Alfred Rizzi (Cambridge, Massachusetts) |
| ABSTRACT | An example robot includes a hydraulic actuator cylinder controlling motion of a member of the robot. The hydraulic actuator cylinder comprises a piston, a first chamber, and a second chamber. A valve system controls hydraulic fluid flow between a hydraulic supply line of pressurized hydraulic fluid, the first and second chambers, and a return line. A controller may provide a first signal to the valve system so as to begin moving the piston based on a trajectory comprising moving in a forward direction, stopping, and moving in a reverse direction. The controller may provide a second signal to the valve system so as to cause the piston to override the trajectory as it moves in the forward direction and stop at a given position, and then provide a third signal to the valve system so as to resume moving the piston in the reverse direction based on the trajectory. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/451669 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 5/00 (20130101) B25J 9/20 (20130101) Original (OR) Class Motor Vehicles; Trailers B62D 57/032 (20130101) Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 9/09 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 901/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032481 | Shelley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Etegent Technologies LTD. (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stuart J. Shelley (Cincinnati, Ohio); Richard Allan Roth, II (Goshen, Ohio); Kevin Joseph Sigmund (Newtown, Ohio) |
| ABSTRACT | A strut suitable for use in parallel manipulator and other applications utilizes an actuation member that is subjected to a quasi-static axial tensioning force to effectively preload the strut to provide axial stiffness and bending flexibility at one or more ends of the strut. |
| FILED | Thursday, December 12, 2019 |
| APPL NO | 17/298843 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 17/0216 (20130101) B25J 19/0091 (20130101) Original (OR) Class Springs; Shock-absorbers; Means for Damping Vibration F16F 1/44 (20130101) F16F 1/366 (20130101) F16F 2224/025 (20130101) F16F 2224/0241 (20130101) F16F 2228/08 (20130101) F16F 2230/0005 (20130101) F16F 2236/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033064 | Oltheten et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| ASSIGNEE(S) | Textron Innovations Inc. (Providence, Rhode Island) |
| INVENTOR(S) | Erik Oltheten (Fort Worth, Texas); Darren Gregory Lang (Dallas, Texas); Charles Eric Covington (Colleyville, Texas) |
| ABSTRACT | An aircraft includes an electronically controlled engine (ECE) and a first and a second throttle control assembly. The first throttle control assembly includes a first throttle fly button configured to command a FLY mode and a first throttle idle button configured to command an IDLE mode. The second throttle control assembly includes a second throttle fly button configured to command the FLY mode and a second throttle idle button configured to command the IDLE mode. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/336264 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 13/0421 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033257 | Plochowietz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne Plochowietz (Palo Alto, California); Matthew Shreve (Mountain View, California) |
| ABSTRACT | Disclosed are methods and systems of controlling the placement of micro-objects on the surface of a micro-assembler. Control patterns may be used to cause phototransistors or electrodes of the micro-assembler to generate dielectrophoretic (DEP) and electrophoretic (EP) forces which may be used to manipulate, move, position, or orient one or more micro-objects on the surface of the micro-assembler. A set of micro-object may be analyzed. Geometric properties of the set of micro-objects may be identified. The set of micro-objects may be divided into multiple sub-sets of micro-objects based on the one or more geometric properties and one or more control patterns. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506247 |
| CURRENT CPC | Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 99/002 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/67271 (20130101) H01L 21/67294 (20130101) H01L 24/95 (20130101) H01L 2224/95133 (20130101) H01L 2224/95145 (20130101) H01L 2924/1461 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49133 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033429 | Rohr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jurgen Rohr (Lexington, Kentucky); Oleg Tsodikov (Lexington, Kentucky); Markos Leggas (Lexington, Kentucky); Caixia Hou (Lexington, Kentucky); Joseph Eckenrode (Lexington, Tennessee); Prithiba Mitra (Lexington, Kentucky); Abhisek Mandal (Lexington, Kentucky) |
| ABSTRACT | Mithramycin (MTM) short side chain ketone (SK) derivatives and MTM short side chain diketone (SDK) derivatives are provided. The MTM SK and MTM SDK derivatives are useful for treatment of cancer or neuro-diseases associated with an aberrant erythroblast transformation-specific transcription factor. Unique MTM SK and MTM SDK derivatives have increased selectively toward ETS transcription factor. |
| FILED | Friday, September 20, 2019 |
| APPL NO | 17/278070 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033512 | Deb |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arjun Deb (Los Angeles, California) |
| ABSTRACT | In certain aspects, provided herein are inhibitory anti-ENPP1 antibodies and antigen binding fragments thereof. In some aspects, provided herein are methods of treating myocardial infarction using the antibodies provided herein. In certain aspects, provided herein are nucleic acid molecules encoding the antibodies provided herein, host cells comprising such nucleic acids, and methods of making the antibodies provided herein using such host cells. In some aspects, also provided herein are pharmaceutical compositions comprising the antibodies provided herein. |
| FILED | Monday, May 03, 2021 |
| APPL NO | 17/306544 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 16/40 (20130101) C07K 16/2896 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/52 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033530 | Gurtowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luke A. Gurtowski (Vicksburg, Mississippi); Manoj K. Shukla (Clinton, Mississippi); David P. Martin (Clinton, Mississippi); Christopher S. Griggs (Vicksburg, Mississippi) |
| ABSTRACT | The invention is a renewable adsorbent material, amine-functionalized chitin (AFC) that can remove the following munitions compounds from solution while providing a concentration-dependent color change: NTO, DNAN, and TNT. Adsorption of the munitions constituents can be adjusted by pH; neutral pH provides maximum adsorption. NTO can desorb from the AFC at pH levels of 2 and 12; DNAN and TNT remain attached to AFC once adsorbed. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/503258 |
| CURRENT CPC | Polysaccharides; Derivatives Thereof C08B 37/003 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 5/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033639 | Macfarlane et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Robert J. Macfarlane (Cambridge, Massachusetts); Jianyuan Zhang (Cambridge, Massachusetts); Peter Jeffries Santos (Cambridge, Massachusetts); Paul Anthony Gabrys (Cambridge, Massachusetts) |
| ABSTRACT | Nanostructures and associated compositions, systems, and methods are provided. In some embodiments, a nanostructure may comprise polymers, intermolecular bonding groups, and a particle. The polymers may be associated with the particle and the intermolecular bonding groups may be associated with at least some of the polymers. In some embodiments, at least some of the intermolecular bonding groups may have a different chemical composition and/or chemical property than the polymers. In some embodiments, nanostructures may reversibly associate with each other via the intermolecular bonding groups to form a material. In some such cases, the intermolecular bonding groups on different nanostructures may reversibly associate with each other. In some embodiments, the nanostructures may be designed, such that the energy required to disassociate at least a portion of the nanostructures in the material is greater than the energy required to dissociate a single association between intermolecular bonding groups. |
| FILED | Thursday, August 05, 2021 |
| APPL NO | 17/394964 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Compositions of Macromolecular Compounds C08L 51/00 (20130101) C08L 51/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033768 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico); Jacob Ongudi Agola (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico); Jacob Ongudi Agola (Albuquerque, New Mexico) |
| ABSTRACT | An encapsulated living (viable) mammalian cell, and methods of making and using that cell, are provided. |
| FILED | Tuesday, September 24, 2019 |
| APPL NO | 17/277256 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) Original (OR) Class C12N 5/0602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033800 | Miller et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | Zymergen Inc. (Emeryville, California) |
| INVENTOR(S) | Aaron Miller (Emeryville, California); Zhihao Wang (Emeryville, California); Jeffrey Mellin (Emeryville, California); Murtaza Shabbir Hussain (Emeryville, California); Steven M. Edgar (Albany, California) |
| ABSTRACT | The present disclosure describes the engineering of microbial cells for fermentative production of 1,5-diaminopentane and provides novel engineered microbial cells and cultures, as well as related 1,5-diaminopentane production methods. |
| FILED | Thursday, November 21, 2019 |
| APPL NO | 17/297383 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/88 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/001 (20130101) Enzymes C12Y 401/01018 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033862 | Chowdhury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | Zymergen Inc. (Emeryville, California) |
| INVENTOR(S) | Anupam Chowdhury (Emeryville, California); Steven M. Edgar (Albany, California); Alexander Glennon Shearer (San Francisco, California); Cara Ann Tracewell (Walnut Creek, California); Stepan Tymoshenko (Emeryville, California); Zhihao Wang (Emeryville, California) |
| ABSTRACT | The present disclosure describes the engineering of microbial cells for fermentative production of 2-oxoadipate and provides novel engineered microbial cells and cultures, as well as related 2-oxoadipate production methods. |
| FILED | Monday, November 25, 2019 |
| APPL NO | 17/297371 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 1/20 (20130101) C12N 9/1025 (20130101) C12N 15/77 (20130101) C12N 15/81 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/50 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/865 (20210501) Enzymes C12Y 203/03014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033893 | Lan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Freeman Lan (San Francisco, California); Benjamin Demaree (Berkeley, California); Iain Clark (San Francisco, California); Adam R. Abate (Daly City, California) |
| ABSTRACT | The present disclosure provides ultrahigh-throughput single cell genomic sequencing methods, referred to herein as “SiC-seq”, which methods include encapsulating single cells in molten gel droplets to facilitate bulk cell lysis and purification of genomic DNA in microgels. Systems and devices for practicing the subject methods are also provided. |
| FILED | Thursday, December 21, 2017 |
| APPL NO | 16/468652 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1044 (20130101) C12N 15/1068 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033913 | DOBI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (BETHESDA, Maryland); CHILDREN'S MEDICAL CENTER CORPORATION (BOSTON, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert DOBI (Rockville, Maryland); Gyorgy PETROVICS (Bethesda, Maryland); Shiv K. SRIVASTAVA (Potomac, Maryland); Hua LI (Bethesda, Maryland); Zoltan SZALLASI (Boston, Massachusetts) |
| ABSTRACT | The present disclosure provides methods of identifying or characterizing prostate cancer comprising detecting in a biological sample the presence or absence of a genomic rearrangement that results in a deletion of an LSAMP gene and detecting in a biological sample the presence or absence of a genomic rearrangement that results in a deletion of a CHD1 gene. In certain embodiments, the patient self-identifies as being of African descent. Also disclosed herein are methods of testing for the presence of genomic rearrangements in an LSAMP gene and a CHD1 gene in a biological sample. The LSAMP and CHD1 genomic rearrangements serves as a biomarker for prostate cancer and can be used to stratify prostate cancer based on ethnicity or the severity or aggressiveness of prostate cancer and/or identify a patient for prostate cancer treatment. Also provided are kits for diagnosing and prognosing prostate cancer and methods of selecting a targeted prostate cancer treatment for a patient. |
| FILED | Thursday, December 12, 2019 |
| APPL NO | 17/312248 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033998 | Wetzel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Research Laboratory ATTN: RDRL-LOC-I (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric D. Wetzel (Baltimore, Maryland); Kevin R. Hart (Milwaukee, Wisconsin); Ryan M. Dunn (Belcamp, Maryland) |
| ABSTRACT | A thermoplastic filament comprising multiple polymers of differing flow temperatures in a geometric arrangement is described. A method for producing such a filament is also described. Because of the difference in flow temperatures, there exists a temperature range at which one polymer is mechanically stable while the other is flowable. This property is extremely useful for creating thermoplastic monofilament feedstock for three-dimensionally printed parts, wherein the mechanically stable polymer enables geometric stability while the flowable polymer can fill gaps and provide strong bonding and homogenization between deposited material lines and layers. These multimaterial filaments can be produced via thermal drawing from a thermoplastic preform, which itself can be three-dimensionally printed. Furthermore, the preform can be printed with precisely controlled and complex geometries, enabling the creation of a filament or fiber with a wide range of applications. A method is also described for including an interior thread that adds structural reinforcement or functional properties, such as electrical conductivity or optical waveguiding, to the filament. |
| FILED | Tuesday, March 10, 2020 |
| APPL NO | 16/814353 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 35/02 (20130101) B29C 55/00 (20130101) B29C 64/106 (20170801) B29C 64/118 (20170801) B29C 65/565 (20130101) B29C 66/53 (20130101) B29C 66/61 (20130101) B29C 66/5241 (20130101) Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/00663 (20130101) B29D 11/00701 (20130101) B29D 11/00721 (20130101) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2069/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/00 (20141201) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/24 (20130101) D01D 5/30 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 8/00 (20130101) D01F 8/10 (20130101) D01F 8/14 (20130101) Original (OR) Class D01F 8/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034491 | Ross et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | First-Light USA, LLC (Seymour, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy B. Ross (Monticello, Illinois); Blake S. Good (Urbana, Illinois); Jacob A. Flagle (New Palestine, Indiana) |
| ABSTRACT | A frame having a clip for securing the frame to an article of clothing or other object. The frame includes a mount for receiving a removable module and a rotatably attached clip. The clip includes an opening for accommodating sewing ribs between portions of a webbing and a gate (which may be a locking wire) moveable between an open position and a closed position at one end of the opening. In the open position, the locking wire removably engages one of a pair of elongated members defining the opening, e.g., by removably engaging that elongated member at a recess in an outside edge thereof, and does not obstruct the opening. When in the closed position, the locking wire removably engages the other of the elongated members, for example by removably engaging that other elongated member at a recess in its outside edge, and obstructs the longitudinal opening. |
| FILED | Monday, August 03, 2020 |
| APPL NO | 16/983252 |
| CURRENT CPC | Lighting Devices or Systems Thereof, Being Portable or Specially Adapted for Transportation F21L 4/027 (20130101) Functional Features or Details of Lighting Devices or Systems Thereof; Structural Combinations of Lighting Devices With Other Articles, Not Otherwise Provided for F21V 21/0885 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses F21K, F21L, F21S and F21V, Relating to Uses or Applications of Lighting Devices or Systems F21W 2111/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034651 | Narasimhan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania); THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Toronto, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srinivasa Narasimhan (McDonald, Pennsylvania); Supreeth Achar (Seattle, Washington); Matthew O'Toole (Palo Alto, California); Kiriakos Neoklis Kutulakos (Toronto, Canada) |
| ABSTRACT | An energy optimized imaging system that includes a light source that has the ability to illuminate specific pixels in a scene, and a sensor that has the ability to capture light with specific pixels of its sensor matrix, temporally synchronized such that the sensor captures light only when the light source is illuminating pixels in the scene. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495000 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/2513 (20130101) Original (OR) Class G01B 11/2518 (20130101) G01B 11/2545 (20130101) Apparatus or Arrangements for Taking Photographs or for Projecting or Viewing Them; Apparatus or Arrangements Employing Analogous Techniques Using Waves Other Than Optical Waves; Accessories Therefor G03B 21/2033 (20130101) Image Data Processing or Generation, in General G06T 17/00 (20130101) Pictorial Communication, e.g Television H04N 5/30 (20130101) H04N 9/3129 (20130101) H04N 13/271 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034848 | Dioumaev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Metrolaser, Inc. (Laguna Hills, California) |
| ASSIGNEE(S) | Metrolaser, Inc. (, None) |
| INVENTOR(S) | Andrei K. Dioumaev (Irvine, California) |
| ABSTRACT | Described herein are systems and methods for Young's modulus and Poisson's ratio determination of an object of arbitrary geometry. A measured vibrational response spectrum of the object is collected, and a simulated vibrational response spectrum of the object is generated. The measured vibrational response spectrum is compared with the simulated vibrational response spectrum. The comparison is treated as a global nonlinear optimization problem. An objective function is proposed to enable comparison of two spectra, which are available on two incompatible frequency scales, and have different number of peaks. The actual values of the Young's modulus and the Poisson's ratio are identified as the best-fitting values that minimize a mismatch between the simulated vibrational response spectrum and the measured vibrational response spectrum. Suitable systems for performing the methods are also provided. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388515 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/045 (20130101) Original (OR) Class G01N 2291/02827 (20130101) Electric Digital Data Processing G06F 30/23 (20200101) G06F 2119/14 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034884 | Oh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia); The Government of the United States of America, as represented by the Secretary, Department of Healt (Rockville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eunkeu Oh (Alexandria, Virginia); Kimihiro Susumu (Alexandria, Virginia); Mason A. Wolak (Alexandria, Virginia); Kirill Gorshkov (Gaithersburg, Maryland) |
| ABSTRACT | Quantum dots conjugated to SARS-CoV-2 Spike protein receptor binding domain (RBD) interact with gold nanoparticles bound to angiotensin converting enzyme 2 (ACE2) and thus undergo energy transfer. This energy transfer indicates RBD/ACE binding and can be used to assay for inhibitors thereof. Moreover, these labeled quantum dots were found to undergo endocytosis in cells expressing ACE2. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/389645 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/588 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2333/165 (20130101) G01N 2500/02 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220036118 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Mohit Gupta (Madison, Wisconsin); Jongho Lee (Madison, Wisconsin) |
| ABSTRACT | In accordance with some embodiments, systems, methods and media for directly recovering planar surfaces in a scene using structured light are provided. In some embodiments, a system comprises: a light source; an image sensor; a processor programmed to: cause the light source to emit a pattern comprising a pattern feature with two line segments that intersect on an epipolar line; cause the image sensor to capture an image including the pattern; identify an image feature in the image, the image feature comprising two intersecting line segments that intersect at a point in the image that corresponds to the first epipolar line; estimate a plane hypothesis associated with the pattern feature based on properties of the pattern feature and properties of the image feature, the plane hypothesis associated with a set of parameters characterizing a plane; and identify a planar surface in the scene based on the plane hypothesis. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 16/945449 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/4604 (20130101) G06K 9/4661 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/521 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220036270 | Benyo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon BBN Technologies Corp. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett Benyo (Ayer, Massachusetts); Fusun Yaman-Sirin (Arlington, Massachusetts) |
| ABSTRACT | Techniques for graph-based handling of service requests are disclosed. The techniques include: receiving a service request that requires at least one resource from multiple available resources; computing a graph-based opportunity cost metric associated with satisfying the service request; and handling the service request based at least on the graph-based opportunity cost metric. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166574 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/5038 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06315 (20130101) Original (OR) Class G06Q 10/06375 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037104 | Rameau et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Physical Sciences, Inc. (Andover, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan D. Rameau (Somerville, Massachusetts); Nicholas R. Craig (Somerville, Massachusetts) |
| ABSTRACT | A triple-point cathode coating and method wherein electrically conductive NEA diamond particles cast or mixed with the adhesive medium and electrically insulative NEA diamond particles are cast or mixed with the adhesive medium to form a plurality of exposed junctions between electrically conductive diamond particles and electrically insulative diamond particles to reduce any electrical charges on a structure coated with the coating. |
| FILED | Friday, July 02, 2021 |
| APPL NO | 17/366552 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 1/3044 (20130101) Original (OR) Class H01J 3/022 (20130101) H01J 9/025 (20130101) H01J 2201/30411 (20130101) H01J 2201/30457 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037408 | Azoulay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Southern Mississippi (Hattiesburg, Mississippi); Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | The University of Southern Mississippi (Hattiesburg, Mississippi); Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Jason D. Azoulay (Hattiesburg, Mississippi); Jarrett Vella (New Carlisie, Ohio); Mohammed I. Vakil (Beavercreek, Ohio); Lifeng Huang (Hattiesburg, Mississippi); Naresh Eedugurala (Hattiesburg, Mississippi) |
| ABSTRACT | A photoconductive infrared detector comprising a substrate, an electrode geometry, and a layer of intrinsically conductive or photoconductive donor-acceptor conjugated polymer. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390277 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/307 (20130101) Original (OR) Class H01L 51/0003 (20130101) H01L 51/0036 (20130101) H01L 51/0043 (20130101) H01L 51/441 (20130101) H01L 51/448 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037469 | Dao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Nanyang Technological University (Singapore, Singapore) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Nanyang Technological University (Singapore, Singapore) |
| INVENTOR(S) | Ming Dao (West Roxbury, Massachusetts); Ju Li (Weston, Massachusetts); Zhe Shi (Cambridge, Massachusetts); Subra Suresh (Singapore, Singapore) |
| ABSTRACT | Compositions and methods related to straining defect doped materials as well as their methods of use in electrical circuits are generally described. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/400097 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 7/008 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02664 (20130101) H01L 29/1054 (20130101) Original (OR) Class H01L 41/0536 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220038032 | Boamah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); CALIFORNIA INSTITUTE OF TECHNOLOGY (PASADENA, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mavis D. Boamah (Evanston, Illinois); Franz M. Geiger (Evanston, Illinois); Thomas F. Miller, III (South Pasadena, California); Jeongmin Kim (Pasadena, California) |
| ABSTRACT | Energy harvesting devices and methods for converting the mechanical energy of a flowing ionic solution, such as rainwater or seawater, into electric energy are provided. The energy harvesting devices include an electric current generating device that includes a metal layer and an amphoteric metal oxide film disposed over a surface of the metal layer. By moving an electric double layer across the surface of the amphoteric metal oxide film, an electric current is generated in the metal layer. |
| FILED | Tuesday, September 17, 2019 |
| APPL NO | 17/276684 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/026 (20130101) Electric Machines Not Otherwise Provided for H02N 1/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220038262 | Blakely |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United State of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | The United State of America as represented by the Secretary of the Army (Washington, District of Columbia) |
| INVENTOR(S) | Jonathan N. Blakely (Madison, Alabama) |
| ABSTRACT | The present disclosure provides a system for securing wireless data communication. The system includes a launcher and a projectile. The launcher has a random number generator, a launcher memory, a launcher encryption/decryption module, and a launcher transceiver. The projectile has a projectile memory, a projectile encryption/decryption module, and a projectile transceiver. Both the launcher encryption/decryption module and the projectile encryption/decryption module are configured to use the one-time pad to encrypt and to decrypt data. The system is configured to establish a temporary datalink at a point in time in which the projectile and the launcher are substantially collocated so that the one-time pad can be transmitted from random number generator located in the launcher to the projectile memory using the temporary datalink. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 16/945168 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 30/006 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0656 (20130101) Original (OR) Class H04L 9/0869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220039095 | Pham |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | the Government of the United States as Represented by the Secretary of the Air Force (Wright Patterson Air Force Base, Ohio) |
| ASSIGNEE(S) | the Government of the United States as Represented by the Secretary of the Air Force (Wright Patterson AFB, Ohio) |
| INVENTOR(S) | Khanh Dai Pham (Albuquerque, New Mexico) |
| ABSTRACT | A system comprising an orbiting transponder in bilateral communication with a hub and a plurality of terminals. The hub automatically allocates power to the transponder based upon prequalification criteria, then dynamically adjusts an uplink carrier to noise ratio to prevent loss of weak signals. The system, and method of operation may further minimize variance in uplink adjustments according to a predictive algorithm. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/305381 |
| CURRENT CPC | Wireless Communication Networks H04W 72/08 (20130101) H04W 72/042 (20130101) H04W 72/0413 (20130101) H04W 72/0473 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220032088 | FRIEDMAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Integrated Sensors, LLC (Ottawa Hills, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter S. FRIEDMAN (Ottawa Hills, Ohio) |
| ABSTRACT | Embodiments are directed generally to an ionizing-radiation beamline monitoring system that includes a vacuum chamber structure with vacuum compatible flanges through which an incident ionizing-radiation beam enters the monitoring system. Embodiments further include at least one scintillator within the vacuum chamber structure that can be at least partially translated in the ionizing-radiation beam while oriented at an angle greater than 10 degrees to a normal of the incident ionizing-radiation beam, a machine vision camera coupled to a light-tight structure at atmospheric/ambient pressure that is attached to the vacuum chamber structure by a flange attached to a vacuum-tight viewport window with the camera and lens optical axis oriented at an angle of less than 80 degrees with respect to a normal of the scintillator, and at least one ultraviolet (“UV”) illumination source facing the scintillator in the ionizing-radiation beam for monitoring a scintillator stability comprising scintillator radiation damage. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/451517 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/00 (20130101) A61N 5/1045 (20130101) A61N 5/1048 (20130101) A61N 5/1049 (20130101) A61N 5/1064 (20130101) A61N 5/1067 (20130101) Original (OR) Class Measurement of Nuclear or X-radiation G01T 1/29 (20130101) G01T 1/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032221 | Gangloff, JR. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John J. Gangloff, JR. (Middletown, Connecticut); Bart Antonie van Hassel (Weatogue, Connecticut); Yehia F. Khalil (Glastonbury, Connecticut); Jagadeswara Reddy Karra (Ellington, Connecticut); Ying She (East Hartford, Connecticut); Zissis A. Dardas (Worcester, Massachusetts) |
| ABSTRACT | An air purification device for use in an air management system includes a housing formed from a polymer matrix composite structure and a filter arranged within the housing. The filter is formed from a porous composite structure including a plurality of filter fibers such that air is configured to flow through the filter. Microbes within the air are configured to contact the plurality of filter fibers. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 16/945273 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 9/014 (20130101) A61L 9/18 (20130101) A61L 2209/14 (20130101) A61L 2209/16 (20130101) Separation B01D 46/0002 (20130101) B01D 46/0028 (20130101) Original (OR) Class B01D 46/4263 (20130101) B01D 2279/40 (20130101) B01D 2279/50 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 13/08 (20130101) B64D 2013/0614 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032233 | CHERTOK |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESOLUTE MARINE ENERGY, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Allan CHERTOK (Bedford, Massachusetts) |
| ABSTRACT | An ocean wave-driven sea water desalination plant employs ocean bottom mounted and hinged flaps driven in oscillating motion by wave surge force to drive rotary pumps which directly pressurize filtered sea water for use by a reverse osmosis (RO) plant and a hydraulic motor-generator set which provides electrical power to RO plant peripheral devices. Means are provided to control the filtered sea water pressure presented to the RO membranes to a preferred set point value. Means are also provided to control the pump reaction torque presented to the flap independently of water pressure by adjusting the effective pump displacement with a pulse width modulated valve shunting the pump ports to maximize captured wave power. Control of pump reaction torque may be effected slowly according to average sea state conditions or in real-time to further enhance captured wave power. |
| FILED | Tuesday, September 24, 2019 |
| APPL NO | 17/278494 |
| CURRENT CPC | Separation B01D 61/06 (20130101) B01D 61/08 (20130101) B01D 61/12 (20130101) B01D 61/025 (20130101) Original (OR) Class B01D 2311/04 (20130101) B01D 2311/14 (20130101) B01D 2311/2649 (20130101) B01D 2313/34 (20130101) B01D 2313/36 (20130101) B01D 2313/243 (20130101) B01D 2313/246 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/004 (20130101) C02F 1/008 (20130101) C02F 1/441 (20130101) C02F 2103/08 (20130101) Machines or Engines for Liquids F03B 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032239 | HO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | W.S. Winston HO (Columbus, Ohio); Yang HAN (Columbus, Ohio) |
| ABSTRACT | Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membranes can comprise a support layer, and a selective polymer layer disposed on the support layer. The selective polymer layer can comprise a selective polymer matrix and carbon nanotubes dispersed within the selective polymer matrix. The carbon nanotubes can comprise multi-walled carbon nanotubes wrapped in a hydrophilic polymer, such as polyvinylpyrrolidone or a copolymer thereof, such as poly(1-vinylpyrrolidone-co-vinyl acetate). The membranes can exhibit selective permeability to gases. As such, the membranes can be for the selective removal of carbon dioxide and/or hydrogen sulfide from hydrogen and/or nitrogen. |
| FILED | Monday, September 16, 2019 |
| APPL NO | 17/276368 |
| CURRENT CPC | Separation B01D 53/228 (20130101) B01D 67/0079 (20130101) B01D 69/10 (20130101) B01D 69/148 (20130101) Original (OR) Class B01D 71/021 (20130101) B01D 71/44 (20130101) B01D 71/60 (20130101) B01D 2257/504 (20130101) B01D 2258/0283 (20130101) B01D 2311/13 (20130101) B01D 2315/10 (20130101) B01D 2323/30 (20130101) B01D 2325/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032240 | Fokema et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aspen Products Group, Inc. (Marlborough, Massachusetts) |
| ASSIGNEE(S) | Aspen Products Group, Inc. (Marlborough, Massachusetts) |
| INVENTOR(S) | Mark D. Fokema (Northborough, Massachusetts); Decio Coutinho (Marlborough, Massachusetts) |
| ABSTRACT | A membrane for fluid species transport includes a porous substrate and a selective-transport layer comprising 2-D-material flakes. The porous substrate defines surface pores with dimensions larger than 2 microns, and the selective-transport layer coats the porous substrate and spans across the surface pores. The porous substrate can be contacted with a liquid or coating to fill or coat the surface pores of the porous substrate. Next, a 2-D-material-flake solution is deposited on the porous substrate. Evaporation of solvent from the deposited 2-D-material-flake solution forms the selective-transport layer. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/303363 |
| CURRENT CPC | Separation B01D 67/0079 (20130101) B01D 67/0088 (20130101) B01D 67/0095 (20130101) B01D 69/02 (20130101) B01D 69/12 (20130101) B01D 69/148 (20130101) Original (OR) Class B01D 71/021 (20130101) B01D 71/024 (20130101) B01D 71/48 (20130101) B01D 2323/04 (20130101) B01D 2323/08 (20130101) B01D 2323/14 (20130101) B01D 2323/28 (20130101) B01D 2323/36 (20130101) B01D 2323/46 (20130101) B01D 2325/02 (20130101) B01D 2325/04 (20130101) B01D 2325/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032369 | QI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhen QI (Tracy, California); Juergen BIENER (Castro Valley, California); Wen CHEN (Livermore, California); Eric DUOSS (Danville, California); Christopher SPADACCINI (Oakland, California); Marcus A. WORSLEY (Hayward, California); Jianchao YE (Tracy, California); Cheng ZHU (Livermore, California) |
| ABSTRACT | The present disclosure relates to a system for using a feedstock to form a three dimensional, hierarchical, porous metal structure with deterministically controlled 3D multiscale porous architectures. The system may have a reservoir for holding the feedstock, the feedstock including a rheologically tuned alloy ink. A printing stage may be used for receiving the feedstock. A processor may be incorporated which has a memory, and which is configured to help carry out an additive manufacturing printing process to produce a three dimensional (3D) structure using the feedstock in a layer-by-layer fashion, on the printing stage. A nozzle may be included for applying the feedstock therethrough onto the printing stage. A de-alloying subsystem may be used for further processing the 3D structure through a de-alloying operation to form a de-alloyed 3D structure having several distinct, differing pore length scales ranging from a digitally controlled macroporous architecture to a nanoporosity introduced by the de-alloying operation. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502538 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/1115 (20130101) B22F 3/1121 (20130101) B22F 3/1146 (20130101) Original (OR) Class B22F 10/10 (20210101) B22F 10/38 (20210101) B22F 10/62 (20210101) B22F 2301/255 (20130101) B22F 2998/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033272 | Treadwell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LaRico Juan Treadwell (Albuquerque, New Mexico); Avi Gabriel Bregman (Albuquerque, New Mexico); Marissa Ringgold (Albuquerque, New Mexico) |
| ABSTRACT | Lanthanide oxides and mixed lanthanide oxides can be produced using furnace or microwave assisted solid-state synthesis. The use of Ln-tri(methylsilyl)amide-based precursors yields spherical nanoparticles. The formation of spherical shaped nanoparticles is likely due to the preferential single-step decomposition of the Ln-TMS as well as the low activation energy to overcome decomposition. Reaction temperature, initial metal ion ratio, and reaction dwell time can be used to control the final nanoparticle size. The method enables solvent-free, high-yield synthesis of morphology-controlled lanthanide oxides. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387417 |
| CURRENT CPC | Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/235 (20200101) C01F 17/241 (20200101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/72 (20130101) C01P 2002/82 (20130101) C01P 2002/88 (20130101) C01P 2004/03 (20130101) C01P 2004/32 (20130101) C01P 2004/62 (20130101) C01P 2004/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033423 | Qu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Qu (Oak Ridge, Tennessee); Huimin Luo (Knoxville, Tennessee); Xin He (Knoxville, Tennessee) |
| ABSTRACT | An ionic liquid composition having the following generic structural formula: wherein Z is N or P, and R1, R2, R3, and R4 are independently selected from hydrogen atom and hydrocarbon groups having one to four carbon atoms with optional interconnection to form a cyclic group that includes Z, and wherein R1, R2, R3, and R4 are all hydrocarbon groups when Z is P, and X− is a phosphorus-containing or carboxylate anion, particularly an organophosphate, organophosphonate, or organophosphinate anion, or a thio-substituted analog thereof containing hydrocarbon groups with at least three carbon atoms. Also described are lubricant compositions comprising the above ionic liquid and a base lubricant, wherein the ionic liquid is dissolved in the base lubricant. Further described are methods for applying the ionic liquid or lubricant composition onto a mechanical device for which lubrication is beneficial, with resulting improvement in friction reduction, wear rate, and/or corrosion inhibition. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/078668 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/5463 (20130101) Original (OR) Class Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 101/04 (20130101) C10M 105/14 (20130101) C10M 107/02 (20130101) C10M 133/04 (20130101) C10M 137/04 (20130101) C10M 137/14 (20130101) C10M 169/04 (20130101) C10M 2201/082 (20130101) C10M 2201/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033768 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico); Jacob Ongudi Agola (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jimin Guo (Albuquerque, New Mexico); C. Jeffrey Brinker (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico); Jacob Ongudi Agola (Albuquerque, New Mexico) |
| ABSTRACT | An encapsulated living (viable) mammalian cell, and methods of making and using that cell, are provided. |
| FILED | Tuesday, September 24, 2019 |
| APPL NO | 17/277256 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) Original (OR) Class C12N 5/0602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033994 | Bidhar |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sujit Bidhar (Carol Stream, Illinois) |
| ABSTRACT | An electrospinning system, method, and apparatus comprises a dual polarity high voltage power supply with much less power out for safe operation, a solution dispensing assembly held at high positive potential by the dual polarity power supply, a Corona discharge assembly held at high negative potential by the dual polarity power supply, and a drum collector held at ground potential wherein a solution is drawn from the solution dispensing assembly to the drum collector thereby forming a fiber mat. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502611 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0038 (20130101) D01D 5/0061 (20130101) D01D 5/0069 (20130101) D01D 5/0076 (20130101) D01D 5/0084 (20130101) Original (OR) Class D01D 5/0092 (20130101) D01D 10/00 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/09 (20130101) D01F 6/94 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034257 | Jordan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | The University of Connecticut (Farmington, Connecticut) |
| INVENTOR(S) | Eric Jordan (Storrs, Connecticut); Chen Jiang (Willimantic, Connecticut); Rishi Kumar (Ashford, Connecticut); Balakrishnan Nair (Sandy, Utah) |
| ABSTRACT | A thermal barrier coating for an internal combustion engine includes an insulating thermal spray coating, where a chosen material of the insulating thermal spray coating has a thermal conductivity lower than 2 W/mK in fully dense form and the chosen material includes a coefficient of thermal expansion within 5 ppm/K of a coefficient of thermal expansion of a material of a component of the internal combustion engine upon which the coating is placed. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/505759 |
| CURRENT CPC | Internal-combustion Piston Engines; Combustion Engines in General F02B 77/11 (20130101) Original (OR) Class Cylinders, Pistons or Casings, for Combustion Engines; Arrangements of Sealings in Combustion Engines F02F 3/12 (20130101) Indexing Scheme Relating to Materials, Material Properties or Material Characteristics for Machines, Engines or Pumps Other Than Non-positive-displacement Machines or Engines F05C 2203/08 (20130101) F05C 2251/048 (20130101) F05C 2253/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034362 | Bolton |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Consolidated Nuclear Security, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin T. Bolton (Clinton, Tennessee) |
| ABSTRACT | A self-governing bearing assembly is disclosed. The self-governing bearing assembly includes a stator and a rotor. The stator includes a brake contacting surface. The stator is one of an outer ring and an inner ring. The rotor includes the other of the outer ring and the inner ring, brake pads, and a circular spring. The brake pads are positioned radially from the brake contacting surface and adapted to rotate with the other of the outer ring and the inner ring. Each of the brake pads includes a pad retention slot. The circular spring is positioned within the pad retention slot of each of the brake pads. The bearing elements are axially aligned with a first bearing portion of the stator and a second bearing portion of the rotor. The bearing elements are adapted to rotationally support the rotor relative to the stator. |
| FILED | Thursday, July 30, 2020 |
| APPL NO | 16/942834 |
| CURRENT CPC | Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 19/06 (20130101) F16C 25/083 (20130101) Original (OR) Class F16C 2380/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034483 | Gladden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Glint Photonics, Inc. (Burlingame, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Gladden (San Mateo, California); Andrew Kim (San Jose, California); Peter Kozodoy (Palo Alto, California); Barbara Kruse (San Francisco, California) |
| ABSTRACT | A luminaire for providing configurable static lighting or dynamically-adjustable lighting. The luminaire uses an array of focusing elements that act on light provided via a corresponding array of sources or via an edge-lit lightguide. Designs are provided for adjusting the number of distinct beams produced by the luminaire, as well as the angular width, angular profile, and pointing angle of the beams. Designs are also provided for systems utilizing the adjustable luminaires in various applications. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 17/476616 |
| CURRENT CPC | Non-electric Light Sources Using Luminescence; Light Sources Using Electrochemiluminescence; Light Sources Using Charges of Combustible Material; Light Sources Using Semiconductor Devices as Light-generating Elements; Light Sources Not Otherwise Provided for F21K 9/61 (20160801) Functional Features or Details of Lighting Devices or Systems Thereof; Structural Combinations of Lighting Devices With Other Articles, Not Otherwise Provided for F21V 5/007 (20130101) F21V 7/0008 (20130101) F21V 14/06 (20130101) Original (OR) Class F21V 17/02 (20130101) Optical Elements, Systems, or Apparatus G02B 3/0006 (20130101) G02B 6/005 (20130101) G02B 6/0036 (20130101) G02B 6/0055 (20130101) G02B 19/0028 (20130101) G02B 19/0066 (20130101) G02B 26/0875 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220034598 — METHODS AND SYSTEMS FOR THERMAL ENERGY STORAGE AND THEIR USE IN BUILDINGS APPLICATIONS
| US 20220034598 | MA |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiwen MA (Golden, Colorado) |
| ABSTRACT | The present disclosure relates to particle-based thermal energy storage (TES) systems employed for the heating and cooling applications for residential and/or commercial buildings. Particle-based TES systems may store thermal energy in the particles during off-peak times (i.e., when electricity demand and/or costs are relatively low) and remove the stored thermal energy for heating or cooling applications for buildings during peak times (i.e., when electricity demand and/or costs are relatively high). |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/386759 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 13/00 (20130101) F28D 19/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034600 | MA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiwen MA (Golden, Colorado); Patrick Gordon DAVENPORT (Boulder, Colorado); Janna MARTINEK (Lafayette, Colorado) |
| ABSTRACT | Methods and devices for long-duration electricity storage using low-cost thermal energy storage and high-efficiency power cycle, are disclosed. In some embodiments it has the potential for superior long-duration, low-cost energy storage. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502138 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 17/005 (20130101) F28D 20/0043 (20130101) Original (OR) Class F28D 20/0056 (20130101) F28D 2020/0078 (20130101) F28D 2020/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034873 | Lindsey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan S. Lindsey (Raleigh, North Carolina); Gongfang Hu (Cary, North Carolina); Rui Liu (Cary, North Carolina); Sijia Liu (Raleigh, North Carolina) |
| ABSTRACT | Described herein are polymeric chromophores that include a dye, a polymer, and optionally a bioconjugate group. A polymeric chromophore may have a structure represented by: A-B-C or C-A-B, wherein A is a dye; B is a polymer comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s); and optionally C, wherein C, when present, comprises a bioconjugate group. Also described herein are compositions comprising the polymeric chromophores and methods of preparing and using the same. |
| FILED | Tuesday, October 01, 2019 |
| APPL NO | 17/280936 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 69/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/533 (20130101) Original (OR) Class G01N 33/582 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220035632 | Cain, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Marvell Asia Pte, Ltd. (Singapore, Singapore) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harold Wade Cain, III (Raleigh, North Carolina); Rabin Andrew Sugumar (Sunnyvale, California); Nagesh Bangalore Lakshminarayana (San Jose, California); Daniel Jonathan Ernst (West St. Paul, Minnesota); Sanyam Mehta (Hopkins, Minnesota) |
| ABSTRACT | A system for processing gather and scatter instructions can implement a front-end subsystem, a back-end subsystem, or both. The front-end subsystem includes a prediction unit configured to determine a predicted quantity of coalesced memory access operations required by an instruction. A decode unit converts the instruction into a plurality of access operations based on the predicted quantity, and transmits the plurality of access operations and an indication of the predicted quantity to an issue queue. The back-end subsystem includes a load-store unit that receives a plurality of access operations corresponding to an instruction, determines a subset of the plurality of access operations that can be coalesced, and forms a coalesced memory access operation from the subset. A queue stores multiple memory addresses for a given load-store entry to provide for execution of coalesced memory accesses. |
| FILED | Thursday, July 30, 2020 |
| APPL NO | 16/944141 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/30043 (20130101) Original (OR) Class G06F 9/30145 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220035633 | Cain, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Marvell Asia Pte, Ltd. (Singapore, Singapore) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harold Wade Cain, III (Raleigh, North Carolina); Nagesh Bangalore Lakshminarayana (San Jose, California); Daniel Jonathan Ernst (West St. Paul, Minnesota); Sanyam Mehta (Hopkins, Minnesota) |
| ABSTRACT | A system for processing gather and scatter instructions can implement a front-end subsystem, a back-end subsystem, or both. The front-end subsystem includes a prediction unit configured to determine a predicted quantity of coalesced memory access operations required by an instruction. A decode unit converts the instruction into a plurality of access operations based on the predicted quantity, and transmits the plurality of access operations and an indication of the predicted quantity to an issue queue. The back-end subsystem includes a load-store unit that receives a plurality of access operations corresponding to an instruction, determines a subset of the plurality of access operations that can be coalesced, and forms a coalesced memory access operation from the subset. A queue stores multiple memory addresses for a given load-store entry to provide for execution of coalesced memory accesses. |
| FILED | Thursday, July 30, 2020 |
| APPL NO | 16/944146 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/546 (20130101) G06F 9/3834 (20130101) G06F 9/30043 (20130101) G06F 9/30047 (20130101) G06F 9/30145 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220035832 | Kannan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramakrishnan Kannan (Oak Ridge, Tennessee); Piyush K. Sao (Oak Ridge, Tennessee); Hao Lu (Oak Ridge, Tennessee); Drahomira Herrmannova (Oak Ridge, Tennessee); Vijay Thakkar (Oak Ridge, Tennessee); Robert M. Patton (Oak Ridge, Tennessee); Richard W. Vuduc (Oak Ridge, Tennessee); Thomas E. Potok (Oak Ridge, Tennessee) |
| ABSTRACT | Data mining large-scale corpora of scholarly publications, such as the full biomedical literature, which may consist of tens of millions of papers spanning decades of research. The present disclosure provides a Distributed Accelerated Semiring All-Pairs Shortest Path (DSNAPSHOT) algorithm for computing shortest paths of a knowledge graph using distributed-memory parallel computers accelerated by GPUs. DSNAPSHOT implementations can analyze connected input graphs with millions of vertices using a large number graphics processing units (e.g., the 24,576 GPUs of the Oak Ridge National Laboratory's Summit supercomputer system). DSNAPSHOT provides sustained performance of about 136*1015 floating-point operations per second (136 petaflop/s) at a parallel efficiency of about 90% under weak scaling and, in absolute speed, 70% of the performance given our computation (in the single-precision tropical semiring or “min-plus” algebra). DSNAPSHOT may enable mining of scholarly knowledge corpora when embedded and integrated into artificial intelligence-driven natural language processing workflows at scale. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/389862 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/26 (20190101) Original (OR) Class G06F 16/24578 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/70 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220035961 | Ziabari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amir Ziabari (Knoxville, Tennessee); Singanallur Venkatakrishnan (Knoxville, Tennessee); Philip R. Bingham (Knoxville, Tennessee); Michael M. Kirka (Knoxville, Tennessee); Vincent C. Paquit (Knoxville, Tennessee); Ryan R. Dehoff (Knoxville, Tennessee); Abhishek Dubey (Rockville, Maryland) |
| ABSTRACT | Nondestructive evaluation (NDE) of objects can elucidate impacts of various process parameters and qualification of the object. Computed tomography (CT) enables rapid NDE and characterization of objects. However, CT presents challenges because of artifacts produced by standard reconstruction algorithms. Beam-hardening artifacts especially complicate and adversely impact the process of detecting defects. By leveraging computer-aided design (CAD) models, CT simulations, and a deep-neutral network high-quality CT reconstructions that are affected by noise and beam-hardening can be simulated and used to improve reconstructions. The systems and methods of the present disclosure can significantly improve the reconstruction quality, thereby enabling better detection of defects compared with the state of the art. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/392645 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/10 (20200101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) Image Data Processing or Generation, in General G06T 7/0002 (20130101) G06T 19/20 (20130101) G06T 2207/10081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220036913 | Candy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jim Candy (Danville, California); Karl A. Fisher (Brentwood, California); Christopher Roland Candy (San Ramon, California) |
| ABSTRACT | A system determines an event location of an event within an indoor environment based on an event sound generated by the event. The system employs time-reversal techniques based on a received event sound to identify the event location as being in the vicinity of one of a plurality of locator devices at locator locations in the environment. The system includes a base array located within the environment that receives an indication that an event has been detected. Upon receiving the event sound, the system generates a time-reversed event sound for each transceiver and transmits via each transceiver the time-reversed event sound for that transceiver. When a locator device receives a time-reversed event sound, the locator device determines whether the event is in the vicinity of that locator location of the locator device and, if so, outputs an indication that the event occurred at that locator location. |
| FILED | Thursday, July 30, 2020 |
| APPL NO | 16/943250 |
| CURRENT CPC | Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 21/04 (20130101) G10L 25/48 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0048 (20130101) H04L 65/601 (20130101) H04L 65/607 (20130101) Wireless Communication Networks H04W 4/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220036943 | Frank et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. Frank (Albuquerque, New Mexico); Erik Debenedictis (Albuquerque, New Mexico) |
| ABSTRACT | A reversible memory element is provided. The reversible memory element comprises a reversible memory cell comprising a Josephson junction and a passive inductor. A ballistic interconnect is connected to the reversible memory cell by a bidirectional input/output port. A polarized input fluxon propagating along the ballistic interconnect exchanges polarity with a stationary stored fluxon in the reversible memory cell in response to the input fluxon reflecting off the reversible memory cell. |
| FILED | Thursday, July 30, 2020 |
| APPL NO | 16/943613 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0354 (20130101) Static Stores G11C 11/44 (20130101) Original (OR) Class G11C 11/1673 (20130101) G11C 11/1675 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/025 (20130101) H01L 39/223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037069 | Kashikhin |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FERMI RESEARCH ALLIANCE, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Kashikhin (Aurora, Illinois) |
| ABSTRACT | Systems and methods for superconducting magnets are disclosed, such systems and methods comprising a primary coil and short-circuited secondary coil. The secondary coil can be made from a stack of superconducting tapes having longitudinal cuts forming closed superconductor loops without splices. The primary coil is used to pump the current into the secondary coil where it circulates continuously generating a permanent magnetic field. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/389252 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 6/04 (20130101) H01F 6/005 (20130101) H01F 6/06 (20130101) Original (OR) Class H01F 41/048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037138 | Schwede et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Spark Thermionics, Inc. (Emeryville, California); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jared William Schwede (Emeryville, California); Igor Bargatin (Wynnewood, Pennsylvania); Samuel M. Nicaise (Philadelphia, Pennsylvania); Chen Lin (Santa Clara, California); John Provine (Emeryville, California) |
| ABSTRACT | A small-gap device system, preferably including two or more electrodes and one or more spacers maintaining a gap between two or more of the electrodes. A spacer for a small-gap device system, preferably including a plurality of legs defining a mesh structure. A method of spacer and/or small-gap device fabrication, preferably including: defining lateral features, depositing spacer material, selectively removing spacer material, separating the spacer from a fabrication substrate, and/or assembling the small-gap device. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497342 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037597 | PALMSTROM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Axel Finn PALMSTROM (Golden, Colorado); Kai ZHU (Littleton, Colorado); Fei ZHANG (Tianjin, China PRC); Joseph Jonathan BERRY (Boulder, Colorado) |
| ABSTRACT | The present disclosure relates to a composition that includes a first layer that includes a perovskite defined by ABX3 and a second layer that includes a perovskite-like material defined by at least one of A′2B′X′4, A′3B′2X′9, A′B′X′4, A′2B′X′6, and/or A′2AB′2X′7, where the first layer is adjacent to the second layer, A is a first cation, B is a second cation, X is a first anion, A′ is a third cation, B′ is a fourth cation, X′ is a second anion, and A′ is different than A. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388235 |
| CURRENT CPC | Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/0036 (20130101) H01G 9/2009 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0002 (20130101) H01L 51/0077 (20130101) Original (OR) Class H01L 51/4253 (20130101) H01L 51/5032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037645 | YUSHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies Inc. (Alameda, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Bogdan ZDYRKO (Atlanta, Georgia); Eugene BERDICHEVSKY (Alameda, California); Alexander JACOBS (Atlanta, Georgia); Alper NESE (Alameda, California); Adam KAJDOS (Stockton, California); Justin YEN (Alameda, California); Justin DOANE (Alameda, California) |
| ABSTRACT | A battery electrode composition is provided that comprises composite particles. Each of the composite particles in the composition (which may represent all or a portion of a larger composition) may comprise a porous electrode particle and a filler material. The porous electrode particle may comprise active material provided to store and release ions during battery operation. The filler material may occupy at least a portion of the pores of the electrode particle. The filler material may be liquid and not substantially conductive with respect to electron transport. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/451022 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/387 (20130101) H01M 4/463 (20130101) H01M 4/582 (20130101) H01M 4/628 (20130101) H01M 4/5815 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037646 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UChicago Argonne, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hsien-Hau Wang (Downers Grove, Illinois); Ritesh Jagatramka (Chicago, Illinois); Samuel Plunkett (Chicago, Illinois); Larry A. Curtiss (Downers Grove, Illinois); Khalil Amine (Oakbrook, Illinois) |
| ABSTRACT | An electrochemical device includes a lithium anode having a red poly(benzonitrile) coating covering at least a portion of the anode; a separator and an air cathode comprising reduced graphene oxide over gas diffusion layer; and an electrolyte comprising an ether solvent, benzonitrile, and a lithium salt. |
| FILED | Tuesday, July 28, 2020 |
| APPL NO | 16/941249 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0562 (20130101) H01M 2004/027 (20130101) H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037698 | DU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhijia DU (Oak Ridge, Tennessee); Ilias BELHAROUAK (Oak Ridge, Tennessee); David L. WOOD III (Oak Ridge, Tennessee) |
| ABSTRACT | A lithium-ion battery comprising: (a) an anode; (b) a cathode; and (c) an electrolyte composition comprising lithium bis(fluorosulfonyl)imide (LiFSI) dissolved in the following solvent system containing at least the following solvent components: (i) ethylene carbonate and/or propylene carbonate in an amount of 5-70 wt % by weight of the solvent system; and (ii) at least one additional solvent selected from acyclic carbonate, acyclic or cyclic ester, and acyclic or cyclic ether solvents having a molecular weight of no more than 110 g/mol, wherein said at least one additional solvent is in an amount of 30-70 wt % by weight of the solvent system; wherein the wt % amounts for solvent components (i) and (ii), or any additional solvent components (if present) sum to 100 wt %, and wherein LiFSI is present in the solvent system in a concentration of 1.2 M to about 2 M. |
| FILED | Monday, December 16, 2019 |
| APPL NO | 17/414149 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/587 (20130101) H01M 10/0525 (20130101) H01M 10/0568 (20130101) Original (OR) Class H01M 10/0569 (20130101) H01M 2300/0025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037751 | Evans et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ESS Tech, Inc. (Wilsonville, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig Evans (West Linn, Oregon); Yang Song (West Linn, Oregon) |
| ABSTRACT | In one example, a system for a flow cell for a flow battery, comprising: a first flow field; and a polymeric frame, comprising: a top face; a bottom face, opposite the top face; a first side; a second side, opposite the first side; a first electrolyte inlet located on the top face and the first side of the polymeric frame; a first electrolyte outlet located on the top face and the second side of the polymeric frame; a first electrolyte inlet flow path located within the polymeric frame and coupled to the first electrolyte inlet; and a first electrolyte outlet flow path located within the polymeric frame and coupled to the first electrolyte outlet. In this way, shunt currents may be minimized by increasing the length and/or reducing the cross-sectional area of the electrolyte inlet and electrolyte outlet flow paths. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/450970 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/20 (20130101) H01M 8/188 (20130101) H01M 8/04186 (20130101) H01M 50/60 (20210101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) Technical Subjects Covered by Former US Classification Y10T 137/4757 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037916 | Abbaszadeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Masoud Abbaszadeh (Clifton Park, New York); Pierino Gianni Bonanni (Loudonville, New York); Reza Ghaemi (Watervliet, New York) |
| ABSTRACT | A method for controlling a distributed power system is provided, the system including an aggregator communicatively coupled to a plurality of nodes, each of the plurality of nodes including an associated load. The method includes receiving, at the aggregator, a commanded power profile from an independent service operator, the commanded power profile including a commanded power deviation for the distributed power system, calculating, using the aggregator, a score for each of the plurality of nodes based on a current operating power of each node, selecting, using the aggregator, a subset of the plurality of nodes based on the calculated scores, and commanding, using the aggregator, each node in the subset to adjust its current power by a respective predetermined amount, the predetermined amounts determined based on the commanded power deviation. |
| FILED | Thursday, September 13, 2018 |
| APPL NO | 17/274980 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/041 (20130101) G05B 13/048 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 13/00002 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220038185 | Passian |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ali Passian (Oak Ridge, Tennessee) |
| ABSTRACT | A system senses analytes through one or more sensors that detect or measure a physical characteristic. The one or more sensor generate a spectroscopic-data signal corresponding to the detection. An edge device communicatively couples the one or more sensors that communicatively couples a wide-area network coupling a cloud service. The edge device includes a data acquisition device that receives spectroscopic data signals from the one or more sensor and a processor that processes the spectroscopic-data signals to identify an analyte. The edge device also includes a transceiver that transmits data identifying the analytes to the cloud service. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381826 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) G01N 21/636 (20130101) Transmission H04B 10/27 (20130101) H04B 10/5057 (20130101) Original (OR) Class Wireless Communication Networks H04W 84/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220038228 | Palmer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRIAD National Security, LLC. (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Palmer (Los Alamos, New Mexico) |
| ABSTRACT | Techniques for framing data in various data transmission contexts are described. A data framing technique may include a transmitter sending a data stream including repeating bits in alternating forward and reverse order. A receiver of the data stream may fold the data stream, and correlate portions of the folded data stream for purposes of validating the data stream and/or identifying an ID in the data stream. In at least some instances, once the receiver validates the data stream, the receiver may accept payload accompanying the data stream. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500211 |
| CURRENT CPC | Multiplex Communication H04J 13/0003 (20130101) H04J 2011/0006 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0006 (20130101) H04L 5/0044 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220039246 | Agustsson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RadiaBeam Technologies, LLC (Santa Monica, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald Agustsson (Venice, California); Salime Boucher (Santa Monica, California); Sergey Kutsaev (Santa Monica, California) |
| ABSTRACT | A particle accelerator can include a first waveguide portion and a second waveguide portion. The first waveguide portion can include a first plurality of cell portions and a first iris portion that is disposed between two of the first plurality of cell portions. The first iris portion can include a first portion of an aperture such that the aperture is configured to be disposed about a beam axis. The first waveguide portion can further include a first bonding surface. The second waveguide portion can include a second plurality of cell portions and a second iris portion that is disposed between two of the second plurality of cell portions. The second iris portion can include a second portion of the aperture. The second waveguide portion can include a second bonding surface. |
| FILED | Wednesday, September 18, 2019 |
| APPL NO | 17/276446 |
| CURRENT CPC | Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 7/18 (20130101) H05H 7/22 (20130101) H05H 9/02 (20130101) Original (OR) Class H05H 2007/225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220031187 | MATTHEWS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cardiac Motion, LLC (Sacramento, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis MATTHEWS (Truckee, California); Xiaoguang LIU (Davis, California); Sonjie BI (Davis, California) |
| ABSTRACT | The present disclosure describes a method and device to monitor the heart of a subject using radio signals. Availability of a portable heart monitor that can be used in a subject's home can increase patient compliance and improve diagnosis rates of cardiac conditions. A mobile heart monitor can be especially useful to those subjects who are elderly, incapacitated, or do not have easy access to a clinic, doctor's office, or hospital. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399140 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0022 (20130101) A61B 5/024 (20130101) A61B 5/361 (20210101) A61B 5/0507 (20130101) Original (OR) Class A61B 5/7282 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220031665 | Mousa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SHIFA BIOMEDICAL CORPORATION (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shaker A. Mousa (Wynantskill, New York); Nabil A. Elshourbagy (West Chester, Pennsylvania); Harold V. Meyers (Weston, Massachusetts); Sherin Salaheldin Abdel-Meguid (Exton, Pennsylvania) |
| ABSTRACT | Disclosed are Nanoformulated compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (PCSK9), as well as therapeutic methods for use of such compounds to reduce LDL- and related cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (CVD), including treatment of hypercholesterolemia. |
| FILED | Tuesday, November 05, 2019 |
| APPL NO | 17/276543 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5138 (20130101) A61K 9/5153 (20130101) A61K 9/5161 (20130101) A61K 31/422 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/55 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032088 | FRIEDMAN |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Integrated Sensors, LLC (Ottawa Hills, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter S. FRIEDMAN (Ottawa Hills, Ohio) |
| ABSTRACT | Embodiments are directed generally to an ionizing-radiation beamline monitoring system that includes a vacuum chamber structure with vacuum compatible flanges through which an incident ionizing-radiation beam enters the monitoring system. Embodiments further include at least one scintillator within the vacuum chamber structure that can be at least partially translated in the ionizing-radiation beam while oriented at an angle greater than 10 degrees to a normal of the incident ionizing-radiation beam, a machine vision camera coupled to a light-tight structure at atmospheric/ambient pressure that is attached to the vacuum chamber structure by a flange attached to a vacuum-tight viewport window with the camera and lens optical axis oriented at an angle of less than 80 degrees with respect to a normal of the scintillator, and at least one ultraviolet (“UV”) illumination source facing the scintillator in the ionizing-radiation beam for monitoring a scintillator stability comprising scintillator radiation damage. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/451517 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/00 (20130101) A61N 5/1045 (20130101) A61N 5/1048 (20130101) A61N 5/1049 (20130101) A61N 5/1064 (20130101) A61N 5/1067 (20130101) Original (OR) Class Measurement of Nuclear or X-radiation G01T 1/29 (20130101) G01T 1/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032458 | CHU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Diligent Robotics, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Diligent Robotics, Inc. (Austin, Texas) |
| INVENTOR(S) | Vivian Yaw-Wen CHU (Austin, Texas); Shuai LI (Sammamish, Washington); Forrest GREEN (Austin, Texas); Peter WORSNOP (Bethesda, Maryland); Andrea Lockerd THOMAZ (Austin, Texas) |
| ABSTRACT | Systems, apparatus, and methods are described for robotic learning and execution of skills. A robotic apparatus can include a memory, a processor, sensors, and one or more movable components (e.g., a manipulating element and/or a transport element). The processor can be operatively coupled to the memory, the movable elements, and the sensors, and configured to obtain information of an environment, including one or more objects located within the environment. In some embodiments, the processor can be configured to learn skills through demonstration, exploration, user inputs, etc. In some embodiments, the processor can be configured to execute skills and/or arbitrate between different behaviors and/or actions. In some embodiments, the processor can be configured to learn an environmental constraint. In some embodiments, the processor can be configured to learn using a general model of a skill. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504130 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 5/00 (20130101) B25J 9/06 (20130101) B25J 9/0081 (20130101) B25J 9/163 (20130101) B25J 9/1661 (20130101) Original (OR) Class B25J 9/1694 (20130101) B25J 11/0005 (20130101) B25J 15/00 (20130101) B25J 19/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033341 | ABU-OMAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SPERO RENEWABLES, LLC (Goleta, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mahdi M. ABU-OMAR (Goleta, California); Daniel H. COLLER (Goleta, California); Ian M. KLEIN (Goleta, California) |
| ABSTRACT | A process for a reactive separation of organic molecules from biomass includes a reaction step for the biomass, a simultaneous extraction step using a solvent, and a filtration step to recover products, wherein the products comprise ferulic acid and/or coumaric acid. The products are extracted from the biomass in a pressurized stirred batch reactor using a liquid extraction solvent and a base in which the ferulate and the coumarate remain. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/481563 |
| CURRENT CPC | Separation B01D 11/028 (20130101) B01D 11/0288 (20130101) B01D 11/0292 (20130101) B01D 15/08 (20130101) Acyclic or Carbocyclic Compounds C07C 51/09 (20130101) C07C 51/47 (20130101) C07C 51/48 (20130101) C07C 67/56 (20130101) Original (OR) Class C07C 67/58 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220032174 | STEPHENS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHAD L. STEPHENS (POQUOSON, Virginia); ALAN T. POPE (POQUOSON, Virginia); WILLIAM HOLLINGSWORTH (FARMVILLE, Virginia) |
| ABSTRACT | A method of providing physiological self-regulation challenges prior to participating in a series of activities or exercises at a series of predefined locations includes determining a physiological goal associated with each location. A sensing device measures a physiological state of a user, and a mobile communication device communicates to a user whether or not the user has achieved the physiological goal for the challenge. The level of difficulty of the physiological goal may be reduced if the user does not meet the goal. The physiological goal may comprise a brain state that is conducive to learning, and the sensing device may be configured to measure brain state values representing cognitive engagement. Upon achievement of each physiological goal, the participant is provided with a reward such as information concerning the current predefined location and/or information concerning the next predefined location. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499431 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/165 (20130101) A61B 5/375 (20210101) A61B 5/1176 (20130101) Card, Board, or Roulette Games; Indoor Games Using Small Moving Playing Bodies; Video Games; Games Not Otherwise Provided for A63F 13/67 (20140902) A63F 13/212 (20140902) Original (OR) Class A63F 13/216 (20140902) A63F 2300/8023 (20130101) Merry-go-rounds; Swings; Rocking-horses; Chutes; Switchbacks; Similar Devices for Public Amusement A63G 31/00 (20130101) A63G 33/00 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00268 (20130101) G06K 9/00288 (20130101) G06K 9/00302 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 19/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220035048 | Schmidt |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | D.K. Schmidt and Associates LLC (Monument, Colorado) |
| ASSIGNEE(S) | D.K. Schmidt and Associates LLC (Monument, Colorado) |
| INVENTOR(S) | David K. Schmidt (Monument, Colorado) |
| ABSTRACT | Disclosed are methods of navigation by satellite positioning system without the aid of any ground-based facilities or supplemental data. An aircraft can autonomously define an approach path for navigation to a landing location by surveying a desired landing area prior to flight, and spatially and mathematically defining a vertical and inclined horizontal plane of interest, along with the target landing point. Also disclosed is a system for using satellite-derived position and velocity information to navigate an aircraft without ground-based facilities or data. Methods defining the approach path through alternate vertical geometries of interest are also disclosed. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/393009 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/47 (20130101) G01S 19/393 (20190801) Original (OR) Class Systems for Controlling or Regulating Non-electric Variables G05D 1/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220036741 | Ozturk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ender Ozturk (Raleigh, North Carolina); Fatih Erden (Raleigh, North Carolina); Haluk Celebi (Raleigh, North Carolina); Ismail Guvenc (Raleigh, North Carolina); Ozgur Ozdemir (Raleigh, North Carolina) |
| ABSTRACT | The present disclosure describes various embodiments of systems and methods of detecting, classifying, and making a threat assessment of an unmanned aerial vehicle (UAV). One such method comprises detecting a radio frequency (RF) signal; determining that the RF signal is generated from an unmanned aerial vehicle (UAV) based on the detected RF signal; classifying at least a make and model of the UAV based on the detected RF signal; sensing for a remote identification field data broadcasted by the UAV; receiving remote identification information of the UAV from a network database, if the network database is available; assessing a threat likelihood of the UAV based on joint processing of at least the RF signal based classification of the UAV and the received remote identification information of the UAV; and signaling an alert containing a description of the UAV and the threat if the UAV is assessed as a harmful threat. |
| FILED | Wednesday, July 28, 2021 |
| APPL NO | 17/387140 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/412 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) G06K 9/6293 (20130101) Traffic Control Systems G08G 5/0004 (20130101) Original (OR) Class G08G 5/0073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220037652 | CHOU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONDA MOTOR CO., LTD. (Tokyo, Japan); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nam Hawn CHOU (New Berlin, Wisconsin); Kaoru OMICHI (Tochigi, Japan); Ryan MCKENNEY (Roseville, Minnesota); Qingmin XU (Dublin, Ohio); Christopher BROOKS (Dublin, Ohio); Simon C. JONES (Whittier, California); Isabelle M. DAROLLES (Azusa, California); Hongjin TAN (Pasadena, California) |
| ABSTRACT | The present disclosure relates to a method of making core-shell and yolk-shell nanoparticles, and to electrodes comprising the same. The core-shell and yolk-shell nanoparticles and electrodes comprising them are suitable for use in electrochemical cells, such as fluoride shuttle batteries. The shell may protect the metal core from oxidation, including in an electrochemical cell. In some embodiments, an electrochemically active structure includes a dimensionally changeable active material forming a particle that expands or contracts upon reaction with or release of fluoride ions. One or more particles are at least partially surrounded with a fluoride-conducting encapsulant and optionally one or more voids are formed between the active material and the encapsulant using sacrificial layers or selective etching. When the electrochemically active structures are used in secondary batteries, the presence of voids can accommodate dimensional changes of the active material. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502246 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/62 (20130101) H01M 4/134 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/582 (20130101) H01M 4/1395 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220031641 | Monje-Deisseroth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Pharmatrophix, Inc. (Menlo Park, California); The Board and Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle Leigh Monje-Deisseroth (Stanford, California); Frank M. Longo (Menlo Park, California) |
| ABSTRACT | Provided are compositions and methods comprising agonists. Also disclosed are agonist compounds, pharmaceutical compositions of agonists, and methods of using the same. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/382045 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/166 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220032257 | Love et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Christopher Love (Somerville, Massachusetts); Hidde L. Ploegh (Brookline, Massachusetts); Jehnna Ronan (Chester, New Hampshire) |
| ABSTRACT | Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody. |
| FILED | Monday, September 20, 2021 |
| APPL NO | 17/479515 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Original (OR) Class B01J 2219/0074 (20130101) B01J 2219/00317 (20130101) B01J 2219/00527 (20130101) B01J 2219/00585 (20130101) B01J 2219/00675 (20130101) B01J 2219/00722 (20130101) B01J 2219/00725 (20130101) B01J 2219/00734 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/50853 (20130101) B01L 2200/12 (20130101) B01L 2200/025 (20130101) B01L 2300/12 (20130101) B01L 2300/0819 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6452 (20130101) G01N 33/505 (20130101) G01N 33/531 (20130101) G01N 33/543 (20130101) G01N 33/577 (20130101) G01N 33/5052 (20130101) G01N 33/6854 (20130101) G01N 33/54366 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 436/809 (20130101) Technical Subjects Covered by Former US Classification Y10T 436/24 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220034913 | Wang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (CLEVELAND, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xinglong Wang (Cleveland, Ohio) |
| ABSTRACT | A method of identifying a subject at risk of a disease or disorder associated with amyloid aggregation includes assaying for Aggregatin in a bodily sample obtained from the subject, wherein the subject is at risk of having the disease or disorder if the Aggregatin is present above a threshold level. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 17/435516 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2333/4709 (20130101) G01N 2800/2821 (20130101) G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220038064 | Kareppagoudr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | Manjunath Kareppagoudr (Corvallis, Oregon); Gabor Temes (Corvallis, Oregon); Jyotindra Shakya (Corvallis, Oregon); Emanuel Caceres (Corvallis, Oregon) |
| ABSTRACT | A slewing mitigation technique is presented where just the right amount of charge is provided at the switching instant to a switch capacitor circuit so that operational transconductance amplifier (OTA) does not need to provide high peak current. This eliminates slewing altogether and allows using OTAs with less static current for the same settling accuracy. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388365 |
| CURRENT CPC | Amplifiers H03F 1/0216 (20130101) H03F 3/005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220031674 | Schultz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael K. Schultz (Iowa City, Iowa); Somya Kapoor (Iowa City, Iowa); Douglas R. Spitz (Iowa City, Iowa) |
| ABSTRACT | The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition. |
| FILED | Friday, July 31, 2020 |
| APPL NO | 16/945323 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/66 (20130101) A61K 31/198 (20130101) A61K 31/437 (20130101) Original (OR) Class A61K 31/4706 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Peptides C07K 16/2818 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220033993 | Kanatzidis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mercouri G. Kanatzidis (Wilmette, Illinois); Wenwen Lin (Willowbrook, Illinois) |
| ABSTRACT | Methods for purifying reaction precursors used in the synthesis of inorganic compounds and methods for synthesizing inorganic compounds from the purified precursors are provided. Also provided are methods for purifying the inorganic compounds and methods for crystallizing the inorganic compounds from a melt. γ and X-ray detectors incorporating the crystals of the inorganic compounds are also provided. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/341899 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 19/007 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 15/00 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/40 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 13/06 (20130101) C30B 13/14 (20130101) C30B 13/34 (20130101) C30B 23/06 (20130101) C30B 35/007 (20130101) Original (OR) Class Measurement of Nuclear or X-radiation G01T 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220035003 | Mosier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bruce P. Mosier (Baltimore, Maryland); Lee S. Stearns (Laurel, Maryland); Daniel D. Winker (Columbia, Maryland); Nicolas Norena Acosta (Silver Spring, Maryland) |
| ABSTRACT | A detector may include processing circuitry configured to receive monitoring data associated with an environment being monitored, where the monitoring data includes a series of frames of three-dimensional point cloud information. The processing circuitry may be further configured to perform image segmentation on the monitoring data to generate segmented three-dimensional data associated with the environment, identify one or more objects in the environment based on subtracting background from the segmented three-dimensional data, convert data associated with the one or more objects from the segmented three-dimensional data into two-dimensional object data, and perform object classification on the two-dimensional object data. |
| FILED | Friday, March 19, 2021 |
| APPL NO | 17/206577 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4802 (20130101) Original (OR) Class G01S 17/42 (20130101) G01S 17/89 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 29/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220035948 | Bentley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel M. Bentley (Washington, District of Columbia); Robert E. Dixon, JR. (Washington, District of Columbia); Ryan M. Luckay (Washington, District of Columbia) |
| ABSTRACT | A method and system of providing material based on a user-initiated request utilizing an electronic database includes receiving search keywords to conduct a search and accessing a first database having previously stored contact information for the particular user in an initial table record. The method includes transforming data in the fields of the record for the particular user in the initial table to generate a record in a sanitized table, accessing a second electronic database having previously stored data structures corresponding to businesses, where each data structure maps selected keyword combinations to corresponding icons, and to particular material corresponding to each keyword combination, and displaying icons associated with search results having corresponding selected keywords near associated result items on an electronic display. The method includes initiating sending of particular material corresponding to the request based on the selected icon and contact data for the user obtained from the sanitized table. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501931 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0481 (20130101) G06F 3/04817 (20130101) G06F 3/04842 (20130101) G06F 16/2282 (20190101) G06F 16/2379 (20190101) G06F 16/9535 (20190101) G06F 21/42 (20130101) G06F 21/6227 (20130101) G06F 21/6245 (20130101) Original (OR) Class G06F 21/6254 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/107 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 67/306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220036675 | McLellan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles P. McLellan (Fairfax, Virginia); Gabriel Michael Yessin (Arlington, Virginia); William Albert Tartal (Baltimore, Maryland) |
| ABSTRACT | Embodiments of a system and method for using a mobile device to assist with the efficient and secure delivery of item. The mobile device can assist an item deliver to lock or unlock secure item delivery receptacles. The mobile device can also notify an item deliverer about particular delivery conditions associated with particular delivery endpoints. The mobile device can further help the item deliverer to determine whether or not he or she is delivering the item to the correct location. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/451301 |
| CURRENT CPC | Locks; Accessories Therefor; Handcuffs E05B 47/00 (20130101) E05B 2047/0072 (20130101) Electric Digital Data Processing G06F 21/44 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/083 (20130101) G06Q 50/32 (20130101) Time or Attendance Registers; Registering or Indicating the Working of Machines; Generating Random Numbers; Voting or Lottery Apparatus; Arrangements, Systems or Apparatus for Checking Not Provided for Elsewhere G07C 9/00571 (20130101) G07C 9/00896 (20130101) Original (OR) Class Wireless Communication Networks H04W 4/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220031831 | Mwangi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Waithaka Mwangi (Manhattan, Kansas); Shehnaz Lokhandwala (Manhattan, Kansas) |
| ABSTRACT | The present disclosure provides immunogenic compositions or vaccines against African Swine Fever Virus (ASFV), methods of making and using such immunogenic compositions or vaccines, and methods of administering such immunogenic compositions or vaccines. In some forms, a plurality of ASFV antigens are combined together into a live-vectored multivalent immunogenic composition. In some forms, the live-vectored multivalent immunogenic composition is a multicistronic expression cassette. |
| FILED | Wednesday, November 13, 2019 |
| APPL NO | 17/309272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220035225 | Aksyuk et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Anatolyevich Aksyuk (Gaithersburg, Maryland); Christian Haffner (Binningen, Switzerland); Henri J. Lezec (Silver Spring, Maryland); Andreas Joerg (Bern, Switzerland); Mikael Mazur (Gothenburg, Sweden); Daniel Chelladurai (Zurich, Switzerland); Jueg Leuthold (Neerach, Switzerland) |
| ABSTRACT | Disclosed is an optoelectromechanical switch that includes: an optical feedline disposed on an isolation substrate that receives resonator light that is subject to optical communication to a resonator when a cavity length of the resonator supports an electromagnetic mode at the wavelength of the resonator light; a resonator including: a low refractive index optical layer and receives substrate electrical counter potential; a non-conductive spacer; the electrically conductive membrane and that receives a membrane electrical potential and deflects toward and away from the electrically conductive high-index optical waveguide based on a difference in potential between the membrane electrical potential and the substrate electrical counter potential; the cavity length that is variable and under electromechanical control. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/490841 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/295 (20130101) Original (OR) Class Multiplex Communication H04J 14/0212 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220032924 | Jeihani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Morgan State University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mansoureh Jeihani (Timonium, Maryland); Samira Ahangari (Baltimore, Maryland); Abdollah Dehzangi (Baltimore, Maryland); Arsalan Hassan Pour (Baltimore, Maryland) |
| ABSTRACT | Systems and methods are disclosed for detecting both the occurrence and type of driver distraction experienced by a driver, determined through evaluation of sensed vehicle conditions or activities, such as steering, braking, lane changing, etc. as detected by one or more sensors on or associated with the vehicle. That detection of the occurrence and type of driver distraction may then be used to initiate another action, including initiating an audible or visual alert to the driver, taking measures to interfere with or stop operation of the device that is causing the distraction, log the occurrence and type of distraction that occurred, and report the occurrence and type of distraction to an outside monitoring computer (such as one associated with a guardian of the driver, an insurer of the vehicle, a law enforcement authority, or the like). To allow such detection, the system and method set forth herein employ machine learning methods to first train a classifier to classify certain driver behaviors (as evidenced by sensed vehicle movements and conditions) as a distraction or non-distraction event, and if a distraction event is detected then to further classify a type of such distraction event, and then to apply the trained classifier to classify the driver's ongoing driving activity. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/389741 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 40/02 (20130101) B60W 40/09 (20130101) Original (OR) Class B60W 50/14 (20130101) B60W 2050/143 (20130101) B60W 2050/146 (20130101) B60W 2540/30 (20130101) B60W 2540/229 (20200201) B60W 2552/00 (20200201) B60W 2756/10 (20200201) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00845 (20130101) G06K 9/6267 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220031653 | Uhl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | George Richard Uhl (Albuquerque, New Mexico); Ian M. Henderson (Sandia Park, New Mexico) |
| ABSTRACT | Provided are compounds capable of enhancing the ability of receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase. Also disclosed is a method of treating a tauopathy or restless leg syndrome in a subject comprising administering to the subject an effective amount of a disclosed compound. Also disclosed are kits comprising the compounds together with instructions for treating a condition and/or a compound known for treating the condition. Finally, disclosed herein is a screening method suitable for identifying positive allosteric modulators of the ability of a receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390497 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/42 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2333/91205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of the Interior (DOI)
| US 20220032241 | YU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | New Mexico Tech University Research Park Corporation (Socorro, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianjia YU (Socorro, New Mexico); Lusi Zou (Socorro, New Mexico); Pri GUSNAWAN (Socorro, New Mexico); Guoyin ZHANG (Socorro, New Mexico); Robert BALCH (Socorro, New Mexico) |
| ABSTRACT | Disclosed herein are compositions, systems, and methods of using dual-layer hollow fiber membranes. The compositions and systems of the disclosure can be used to desalinate water from an underground formation. The compositions and systems of the disclosure can be further used to capture carbon dioxide from a gaseous sample. |
| FILED | Friday, July 16, 2021 |
| APPL NO | 17/377844 |
| CURRENT CPC | Separation B01D 69/02 (20130101) B01D 69/08 (20130101) B01D 71/34 (20130101) Original (OR) Class B01D 2325/02 (20130101) B01D 2325/04 (20130101) B01D 2325/38 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/44 (20130101) C02F 2101/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, February 03, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
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FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
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