FedInvent™ Patent Applications
Application Details for Thursday, February 17, 2022
This page was updated on Friday, February 18, 2022 at 02:56 PM GMT
Department of Health and Human Services (HHS)
| US 20220047213 | Apkarian et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Apkar Vania Apkarian (Chicago, Illinois); Etienne Vachon-Presseau (Montreal, Canada); Sara E. Berger (Evanston, Illinois); Thomas J. Schnitzer (Chicago, Illinois) |
| ABSTRACT | Systems as described herein can include diagnosing and treating patients with chronic conditions, such as chronic back pain. A transition to chronic pain can include brain adaptations that can carve the state of chronic pain. Additionally, pain characteristics, pain related disability, and responses to treatment can be at least partially determined by psychological factors and/or personality properties. Patients can be classified into a plurality (e.g., five) neuropsychotypes based on set of brain imaging data and psychological assessment. Once classified, personalized treatment options can be developed for chronic pain patients. However, it should be noted that any of a variety of patients with any of a variety of chronic disorders such as, but not limited to, chronic negative mood disorders, such as PTSD, depression, and anxiety, can be diagnosed and treated using any of the systems and processes described herein. |
| FILED | Monday, October 28, 2019 |
| APPL NO | 17/289801 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/165 (20130101) A61B 5/4815 (20130101) A61B 5/4824 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4806 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 10/60 (20180101) G16H 20/70 (20180101) G16H 30/20 (20180101) G16H 50/20 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047228 | Hull |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
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| INVENTOR(S) | Holly Hull (Leawood, Kansas) |
| ABSTRACT | A medical imaging support includes a substantially flat radiotransparent platform, a plurality of radiotransparent flaps, and closure mechanisms. The platform has a longitudinal direction between a top edge and a bottom edge. The plurality of sets of radiotransparent flaps have a first set of the radiotransparent flaps positioned closer to the top edge in the longitudinal direction than the second set of radiotransparent flaps, and at least one set of flaps includes a first flap and a second flap where the first flap is fixed to the platform proximate a first side edge and the second flap is fixed to the platform proximate a second side edge. The closure mechanisms are positioned on the first flap or second flap of each set of radiotransparent flaps, wherein the closure mechanism selectively fixes the first flap to the second flap of each set of radiotransparent flaps. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399626 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/0421 (20130101) Original (OR) Class A61B 2503/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047318 | Curley |
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| FUNDED BY |
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| APPLICANT(S) | Thermedical, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | Thermedical, Inc. (Waltham, Massachusetts); Thermedical, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Michael G. Curley (Weston, Massachusetts) |
| ABSTRACT | Devices, systems, and methods for degassing fluid prior to applying fluid to a treatment site during ablation therapy are provided. In one embodiment, an ablation system can include an elongate body, an ablation element, a heating assembly, and a fluid source. Fluid in the fluid source can be at least partially degassed prior to being provided as part of the system, or, in some embodiments, a degassing apparatus can be provided that can be configured to degas fluid within the system prior to applying the fluid to the treatment site. The degassing apparatus can include one or more gas-permeable and fluid-impermeable tubes disposed therein, which can allow gas to be removed from fluid passing through the apparatus. Other exemplary devices, systems, and methods are also provided. |
| FILED | Thursday, September 02, 2021 |
| APPL NO | 17/465780 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 18/04 (20130101) A61B 18/16 (20130101) A61B 18/082 (20130101) Original (OR) Class A61B 18/1477 (20130101) A61B 2018/00773 (20130101) Positive-displacement Machines for Liquids; Pumps F04B 17/03 (20130101) F04B 41/02 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49016 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047538 | BANERJEE et al. |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
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| INVENTOR(S) | Amrita BANERJEE (Nashville, Tennessee); Ken S. LAU (Nashville, Tennessee) |
| ABSTRACT | Methods for preventing, treating or suppressing an inflammatory bowel disease, particularly Crohn's Disease are disclosed. The methods include administering a pharmaceutical composition that enhances tuft cell specification. The pharmaceutical composition can comprise succinic acid or a pharmaceutically acceptable salt, ester, solvate, or prodrug thereof. |
| FILED | Thursday, February 06, 2020 |
| APPL NO | 17/428734 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/10 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/194 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047546 | Benbrook et al. |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
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| INVENTOR(S) | Doris Mangiaracina Benbrook (Oklahoma City, Oklahoma); Satish Kumar Ramraj (Oklahoma City, Oklahoma) |
| ABSTRACT | Drug combinations of a heteroarotinoid (e.g., SHetA2), and an Azabicyclooctan-3-one derivative (e.g., PRIMA-1 or PRIMAMET) and/or, a CDK4/6 inhibitor (e.g., Palbociclib, Abemaciclib, or Ribociclib), which are synergistically-effective as anti-cancer treatments, and kits and methods of use of such drug combinations. |
| FILED | Thursday, September 12, 2019 |
| APPL NO | 17/276032 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/382 (20130101) Original (OR) Class A61K 31/439 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047571 | Olaleye |
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| APPLICANT(S) | Texas Southern University (Houston, Texas) |
| ASSIGNEE(S) | Texas Southern University (Houston, Texas) |
| INVENTOR(S) | Omonike A. Olaleye (Houston, Texas) |
| ABSTRACT | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has emerged as an ongoing global pandemic. Presently, there are no clinically approved vaccines nor drugs for COVID-19. Hence, there is an urgent need to accelerate the development of effective antivirals. One or more members of the 8-Hydroxyquinoline and Benzylamine structural classes inhibited SARS-CoV-2 infection induced cytopathic effect in vitro, inhibited the exopeptidase activity of angiotensin converting enzyme 2 (ACE2), and disrupted the binding between ACE2 and the Spike protein of SARS-CoV-2. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/402419 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) Original (OR) Class A61K 31/137 (20130101) A61K 33/30 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047576 | MIRANKER et al. |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
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| INVENTOR(S) | Andrew MIRANKER (Guilford, Connecticut); Sunil KUMAR (New York, New York) |
| ABSTRACT | The present invention provides novel compounds that are quinoline foldamers. Such foldamers stabilize and bind to islet amyloid polypeptide (IAPP). In certain embodiments, the quinoline foldamers of the invention are soluble and cross biological membranes without cellular assistance. The present invention further provides novel method of preventing or treating diabetes in a subject in need thereof by administering to the subject an effective amount of at least one quinoline foldamer of the invention. The present invention further provides novel method of preventing or treating a neurodegenerative disease caused by a misfolded and/or unstructured protein in a subject in need thereof by administering to the subject an effective amount of at least one quinoline foldamer of the invention. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461489 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) Original (OR) Class A61K 45/06 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047616 | NEWMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | PHOENIX BIOTECHNOLOGY, INC. (San Antonio, Texas) |
| ASSIGNEE(S) | PHOENIX BIOTECHNOLOGY, INC. (San Antonio, Texas) |
| INVENTOR(S) | Robert A. NEWMAN (St. Helena, South Carolina); Otis C. ADDINGTON (San Antonio, Texas) |
| ABSTRACT | A method of treating HTLV-1 virus infection. A composition having at least one cardiac glycoside is used to treat viral infection. The composition can further include at least one triterpene. Alternatively, the composition comprises the combination of at least one cardiac glycoside and at least one, at least two, or at least three triterpenes. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512183 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047631 | SCHREIBER et al. |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Hans SCHREIBER (Chicago, Illinois); David KRANZ (Champaign, Illinois); Karin SCHREIBER (Chicago, Illinois); Yanran HE (Chicago, Illinois); Preeti SHARMA (Urbana, Illinois) |
| ABSTRACT | The disclosure provides Tn epitope-specific chimeric antigen receptors and scFvs, including soluble scFvs and multimeric scFvs, as well as methods of identifying cancer subjects and cancer subject sub-populations amenable to anti-Tn immunotherapy and methods of treating cancer. |
| FILED | Wednesday, September 11, 2019 |
| APPL NO | 17/250832 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70535 (20130101) C07K 16/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047639 | TAMPLIN et al. |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
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| INVENTOR(S) | Owen James TAMPLIN (Middleton, Wisconsin); Kostandin PAJCINI (Chicago, Illinois) |
| ABSTRACT | Disclosed are methods of preparing hematopoietic stem cells and progenitor cells (HSPCs) for transplant into a subject and to methods of using the treated cells. More particularly, methods of the invention comprise treating HSPCs ex vivo with an effective amount of a GABBR1 agonist and administering the treated HSPCs to the subject. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401657 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) C12N 2501/999 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047653 | LYNCH et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Susan V. LYNCH (Piedmont, California); Elze RACKAITYTE (San Francisco, California) |
| ABSTRACT | Provided herein are, inter alia, methods and compositions for treating, preventing, or reducing the risk of dysbiosis, inflammation, inflammatory diseases, childhood obesity, and premature birth. Included are methods and compositions for increasing or promoting healthy or normal immune system maturation. In aspects, provided herein are methods and compositions for detecting and isolating bacterial strains. Isolated bacterial strains and culture methods are also provided. |
| FILED | Tuesday, August 06, 2019 |
| APPL NO | 17/266952 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/741 (20130101) A61K 35/747 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 2502/30 (20130101) C12N 2502/1157 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047672 | Rosenblum et al. |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Michael D. Rosenblum (San Francisco, California); Kelly M. Mahuron (San Francisco, California); Joshua M. Moreau (San Francisco, California); Mariela Pauli (San Francisco, California); Pooja Mehta (San Francisco, California) |
| ABSTRACT | The present disclosure provides compositions and methods for treating an autoimmune disorder or cancer in a subject. In some embodiments, the methods include the use of modified T cells (e.g., CD8+ T cells) that have high layilin expression. In other embodiments, the methods include the use of layilin-binding proteins. Also provided herein are methods and compositions for identifying modulators of layilin or beta-integrin complex interaction. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/396475 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 38/1709 (20130101) Original (OR) Class A61K 39/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/06 (20180101) Peptides C07K 16/18 (20130101) C07K 2317/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047683 | STONE |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Everett STONE (Austin, Texas) |
| ABSTRACT | Disclosed herein are compositions related to conjugated polypeptides with MTA/ADO-degrading enzyme activity. The conjugated polypeptides are engineered to allow for maximal conjugation while maintaining catalytic activities. Also disclosed are nucleic acids, expression vectors, and host cells related to the conjugated polypeptides. Further disclosed are methods of using the pharmaceutical formulations comprising above to treat cancer. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516639 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047695 | Xu et al. |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Ziyang Xu (Philadelphia, Pennsylvania); Daniel W. Kulp (Moorestown, New Jersey); David B. Weiner (Merion, Pennsylvania) |
| ABSTRACT | Disclosed are compositions comprising an expressible nucleic acid sequence comprising a first nucleic acid sequence comprising a leader sequence or a pharmaceutically acceptable salt thereof; and a second nucleic acid sequence comprising a sequence that encodes a self-assembling polypeptide or a pharmaceutically acceptable salt thereof. In some embodiments, the expressible nucleic acid sequence further comprises a nucleic acid sequence encoding at least one viral antigen or a pharmaceutically acceptable salt thereof. In some embodiments, the expressible nucleic acid sequence further comprises at least one nucleic acid sequence encoding a linker. Also disclosed are pharmaceutical compositions comprising these compositions and methods of using the disclosed compositions. |
| FILED | Monday, December 23, 2019 |
| APPL NO | 17/417096 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Original (OR) Class A61K 2039/53 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Enzymes C12Y 205/01078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047709 | Gray et al. |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); David Scott (Newton, Massachusetts); Zhengnian Li (Brookline, Massachusetts); Benika J. Pinch (Brookline, Massachusetts); Calla Olson (Brookline, Massachusetts); Eric S. Fischer (Chestnut Hill, Massachusetts); Radoslaw P. Nowak (Boston, Massachusetts); Katherine A. Donovan (Brookline, Massachusetts) |
| ABSTRACT | Disclosed are bifunctional compounds (degraders) that target Wee1 tyrosine kinase for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease. |
| FILED | Thursday, September 26, 2019 |
| APPL NO | 17/278890 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/502 (20130101) A61K 31/519 (20130101) A61K 47/55 (20170801) Original (OR) Class A61K 47/545 (20170801) A61K 47/555 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047719 | Scott et al. |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan Alexander Scott (Evanston, Illinois); Trevor Stack (Evanston, Illinois) |
| ABSTRACT | Provided herein are multi-nanoparticle formulations. Also provided herein are methods for enhancing circulation time and/or cell-targeting efficacy of an effector nanoparticle by administering an endocytosis inhibitory nanoparticle and an effector nanoparticle. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/445285 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/6907 (20170801) A61K 47/6935 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047721 | Hirsch et al. |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
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| INVENTOR(S) | Matthew Louis Hirsch (Chapel Hill, North Carolina); Richard Jude Samulski (Chapel Hill, North Carolina) |
| ABSTRACT | This invention relates to viral vectors for delivery of alpha-L-iduronidase to the cornea of a subject and methods of using the same for treatment and prevention of corneal clouding and blindness in a subject due to mucopolysaccharidosis I. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/407718 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0048 (20130101) A61K 35/76 (20130101) A61K 48/00 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/00 (20180101) Peptides C07K 14/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) C12N 9/2411 (20130101) C12N 15/86 (20130101) C12N 2710/10044 (20130101) C12N 2750/14141 (20130101) C12N 2750/14143 (20130101) C12N 2800/22 (20130101) Enzymes C12Y 302/01076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047728 | GUO et al. |
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| APPLICANT(S) | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (Lexington, Kentucky) |
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| INVENTOR(S) | Peixuan GUO (Columbus, Ohio); Hui LI (Columbus, Ohio); Wei LUO (Lexington, Kentucky) |
| ABSTRACT | The presently-disclosed subject matter relates to an artificial RNA nanostructure and method of use thereof. In particular, the presently-disclosed subject matter relates to RNA nanoparticles and RNA dendrimers, and methods of disease diagnosis and treatments using the RNA nanostructure and RNA dendrimers. |
| FILED | Monday, November 09, 2020 |
| APPL NO | 17/093038 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/12 (20130101) A61K 51/0491 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047729 | Fiser et al. |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andras Fiser (New York, New York); Rojan Shrestha (Bronx, New York); Steven C. Almo (Pelham, New York); Sarah, C. Garrett (Bronx, New York) |
| ABSTRACT | Disclosed are human Programmed Cell Death-1 (PD-1) receptor mutants having selectivity for PD-L1 compared to PD-L2, methods of obtaining the mutants, and uses of the mutants for treatment and imaging. |
| FILED | Wednesday, September 18, 2019 |
| APPL NO | 17/278869 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/08 (20130101) Original (OR) Class Peptides C07K 14/70532 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047730 | Tang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yng Tang (Davis, California); Julie L. Sutcliffe (Davis, California) |
| ABSTRACT | The present invention provides peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates comprise a moiety such as a PEG moiety, an imaging agent, or a therapeutic agent. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue. Compositions and kits containing the peptide conjugates of the present invention are also provided herein. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504072 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/1777 (20130101) A61K 47/60 (20170801) A61K 47/62 (20170801) A61K 51/088 (20130101) Original (OR) Class Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047778 | Shah et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Nisarg J. Shah (San Diego, California); Angelo S. Mao (Cambridge, Massachusetts); Matthew D. Kerr (Carlsbad, California); David J. Mooney (Sudbury, Massachusetts); David T. Scadden (Weston, Massachusetts) |
| ABSTRACT | The present invention provides compositions and methods that modulate the immune system in a subject. |
| FILED | Thursday, December 12, 2019 |
| APPL NO | 17/414037 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/32 (20130101) A61K 38/19 (20130101) A61K 38/1841 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/20 (20130101) A61L 27/26 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) Original (OR) Class A61L 27/56 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) A61L 2400/06 (20130101) A61L 2400/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047781 | Bocks et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (CLEVELAND, Ohio); MICHIGAN TECHNOLOGY UNIVERSITY (Houghton, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Bocks (Shaker Heights, Ohio); Jaroslaw Drelich (Houghton, Michigan); Jeremy Goldman (Hougton, Michigan); Ehsan Mostaed (Hougton, Michigan) |
| ABSTRACT | An endoluminal prosthesis includes an implantable scaffold and/or stent substrate which is convertible from a compressed first geometric shape to a radially dilated dimensionally stable second tubular second geometric shape, the scaffold and/or stent substrate comprising a bioresorbable zinc alloy, the zinc alloy including at least at least four alloying elements selected from the group consisting of silver (Ag) in an amount of about 1.0 wt. % to about 6.0 wt. %, manganese (Mn) in an amount of about 0.1 wt. to about 2.0 wt. %, zirconium (Zr) in an amount of about 0.05 wt. % to about 1.0 wt. %, copper (Cu) in an amount of about 0.5 wt. % to about 1.2 wt. %, and optionally titanium (Ti) in an amount of 0 to about 0.4 wt. %, with the balance of the alloy being zinc and incidental impurities. |
| FILED | Saturday, August 14, 2021 |
| APPL NO | 17/402513 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/08 (20130101) A61L 31/16 (20130101) A61L 31/022 (20130101) Original (OR) Class A61L 31/148 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047837 | Zapol et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David G. Zapol (San Francisco, California); Gregory W. Hall (Belmont, Massachusetts); Wolfgang Scholz (Beverly, Massachusetts); Benjamin Apollonio (Lunenburg, Massachusetts); Frank Heirtzler (Londonderry, New Hampshire); Andrew Ferencz (Southborough, Massachusetts) |
| ABSTRACT | Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332915 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/00 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/04 (20130101) A61M 16/12 (20130101) Original (OR) Class A61M 16/022 (20170801) A61M 16/024 (20170801) A61M 16/0057 (20130101) A61M 16/0093 (20140204) A61M 16/101 (20140204) A61M 16/107 (20140204) A61M 16/202 (20140204) A61M 16/0666 (20130101) A61M 2202/0275 (20130101) A61M 2202/0283 (20130101) A61M 2205/05 (20130101) A61M 2205/054 (20130101) A61M 2205/80 (20130101) A61M 2205/125 (20130101) A61M 2205/502 (20130101) A61M 2205/3584 (20130101) A61M 2205/8206 (20130101) A61M 2209/088 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048033 | ZHANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William Marsh Rice University (Houston, Texas) |
| ASSIGNEE(S) | William Marsh Rice University (Houston, Texas) |
| INVENTOR(S) | David Yu ZHANG (Houston, Texas); Dmitriy A. KHODAKOV (Houston, Texas); Xuemeng ZHANG (Houston, Texas) |
| ABSTRACT | The disclosure describes apparatus and methods for multiplexed amplification and detection of nucleic acid targets in a sample. Embodiments of the present disclosure include a mechanical system configured to provide loading, vertical positioning and clamping of a chip; a thermal control system configured to maintain distinct temperatures of the chip, and an optical fluorescence imaging system. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/276098 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 7/525 (20130101) Original (OR) Class B01L 9/52 (20130101) B01L 2200/04 (20130101) B01L 2200/147 (20130101) B01L 2200/0663 (20130101) B01L 2200/0689 (20130101) B01L 2300/027 (20130101) B01L 2300/1805 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048788 | CHAKRAVARTY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Shatadru CHAKRAVARTY (Rolla, Missouri); Erik M. SHAPIRO (Okemos, Michigan) |
| ABSTRACT | A nanoparticle composition is provided. The nanoparticle composition includes a plurality of nanoparticles, each nanoparticle of the plurality having a core including tantalum oxide, and a covalent coating covalently bound to the core. The covalent coating includes a surface modifier selected from the group consisting of (3-aminopropyl)trimethoxy silane (APTMS), (3-aminopropyl)triethoxy silane (APTES), APTMS-methoxy-poly(ethylene-glycol)-succinimidyl glutarate (APTMS-m-PEG-glutarate), APTES-methoxy-poly(ethylene-glycol)-succinimidyl glutarate (APTES-m-PEG-glutarate), 2-[methoxy (polyethyleneoxy)-9-12-propyl] trimethoxysilane (PEG-Silane), hexadecyltriethoxy silane, and combinations thereof. Methods of synthesizing and using the nanoparticle composition are also provided. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/367919 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0428 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 35/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048863 | Shen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | City of Hope (Duarte, California); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Binghui Shen (La Verne, California); Judith Campbell (Pasadena, California); Li Zheng (Arcadia, California); Hongzhi Li (Duarte, California); David Horne (Duarte, California); Jun Xie (Duarte, California); Kenneth Karanja (Maple Grove, Minnesota) |
| ABSTRACT | Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/515252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 215/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048872 | Pomper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin G. Pomper (Baltimore, Maryland); Ronnie C. Mease (Fairfax, Virginia); Ying Chen (Timonium, Maryland); Sangeeta Ray (Ellicott City, Maryland) |
| ABSTRACT | Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed. |
| FILED | Wednesday, May 26, 2021 |
| APPL NO | 17/331113 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0032 (20130101) A61K 49/0052 (20130101) A61K 51/044 (20130101) A61K 51/0421 (20130101) A61K 51/0446 (20130101) A61K 51/0453 (20130101) A61K 51/0472 (20130101) Heterocyclic Compounds C07D 209/12 (20130101) C07D 209/14 (20130101) C07D 209/24 (20130101) C07D 213/04 (20130101) C07D 249/04 (20130101) C07D 255/02 (20130101) C07D 257/02 (20130101) Original (OR) Class C07D 311/14 (20130101) C07D 311/20 (20130101) C07D 311/82 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/027 (20130101) C07F 13/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 2800/342 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048879 | Ali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Worcester Polytechnic Institute (Worcester, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rameez Ali (Worcester, Massachusetts); Anita Mattson (Holden, Massachusetts) |
| ABSTRACT | Methods, compositions, and kits are provided for synthesizing bioactive chromane, the method including: constructing a tertiary ether stereocenter enantioselectively by catalyzed alkynylation of a substituted chromenone to obtain a chromanone; reducing alkyne and ketone in the chromanone to obtain a chroman; and converting ester to methyl group thereby obtaining chromane. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400468 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/545 (20170801) Heterocyclic Compounds C07D 311/22 (20130101) C07D 311/66 (20130101) Original (OR) Class C07D 409/06 (20130101) C07D 411/06 (20130101) C07D 413/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048924 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CRINETICS PHARMACEUTICALS, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sangdon Han (San Diego, California); Sun Hee KIM (San Diego, California); Yunfei ZHU (San Diego, California) |
| ABSTRACT | Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511326 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/08 (20130101) A61K 9/2013 (20130101) A61K 9/2054 (20130101) A61K 9/4825 (20130101) Heterocyclic Compounds C07D 401/14 (20130101) C07D 498/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048942 | Armstrong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Scott Armstrong (Wayland, Massachusetts); Jun Qi (Sharon, Massachusetts) |
| ABSTRACT | Provided herein are bifunctional compounds with a moiety or domain that is a binder of the ubiquitin receptor RPN13 and another moiety or domain that is a binder of a target protein DOT1L to induce degradation of DOT1L. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers). Provided also are methods of inducing the degradation of DOT1L by administering a bifunctional compound or composition described herein, wherein one domain of the bifunctional compound is a binder of the ubiquitin receptor RPN13 and another domain of the compound is a binder of the target protein DOT1L in a subject. |
| FILED | Thursday, January 09, 2020 |
| APPL NO | 17/421285 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048946 | Aldrich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jane V. Aldrich (Lawrence, Kansas); S P Sanjeewa Nilendra Senadheera (Lawrence, Kansas) |
| ABSTRACT | Cyclic tetrapeptide stereochemical isomers of CJ-15,208, pharmaceutical compositions from such cyclic tetrapeptides, and methods of using such pharmaceutical compositions. The cyclic tetrapeptide compounds and pharmaceutical compositions disclosed herein are potent analgesics active in several pain models with generally minimal tolerance and reduced likelihood to induce addiction relative to other known opiates. |
| FILED | Monday, April 26, 2021 |
| APPL NO | 17/240638 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 5/12 (20130101) C07K 5/126 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048961 | CROOK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | FRED HUTCHINSON CANCER RESEARCH CENTER (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary CROOK (Bothell, Washington); Mi-Youn BRUSNIAK (Lynnwood, Washington); James OLSON (Seattle, Washington); Andrew James MHYRE (Kenmore, Washington); Chunfeng YIN (Redmond, Washington); Gene Gregory HOPPING (Seattle, Washington); Roland STRONG (Seattle, Washington) |
| ABSTRACT | Described herein are peptides and variants thereof as well as peptide constructs comprising peptides conjugated to, linked to, or fused to agents, wherein the peptides and peptide constructs are capable of binding TfR. Binding of a peptide or peptide construct as described herein to TfR can enable transcytosis across an endothelial layer, e.g., the blood brain barrier, or the crossing of a cell membrane. Pharmaceutical compositions and uses of peptides and peptide constructs, as well as methods of designing and manufacturing such peptides and peptide constructs, to treat a disease or condition are also described herein. |
| FILED | Friday, December 13, 2019 |
| APPL NO | 17/312703 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/645 (20170801) A61K 49/0056 (20130101) A61K 51/088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) A61P 25/04 (20180101) A61P 25/28 (20180101) A61P 35/00 (20180101) Peptides C07K 14/47 (20130101) Original (OR) Class C07K 2319/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048962 | DICKINSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | The University of Chicago (Chicago, Illinois) |
| INVENTOR(S) | Bryan C. DICKINSON (Chicago, Illinois); Simone RAUCH (Chicago, Illinois) |
| ABSTRACT | Aspects of the disclosure relate to a RNA regulatory system comprising at least one of each: i) a RNA hairpin binding domain; ii) a RNA targeting molecule comprising a RNA targeting region and at least one hairpin structure, wherein the hairpin structure of the RNA targeting molecule specifically binds to i; and iii) a RNA regulatory domain. |
| FILED | Friday, January 03, 2020 |
| APPL NO | 17/309936 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/4702 (20130101) Original (OR) Class C07K 2319/85 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048965 | Merchant et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Medicenna Therapeutics Inc. (Toronto, Canada); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Silver Spring, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fahar Merchant (Vancouver, Canada); Raj K. Puri (Potomac, Maryland); Bharatkumar H. Joshi (Rockville, Maryland) |
| ABSTRACT | The present invention relates to interleukin-4 receptor binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that include an interleukin-4 receptor binding protein moiety joined to a pro-apoptotic Bcl-2 family member protein moiety. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397287 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/193 (20130101) A61K 38/1761 (20130101) A61K 38/2026 (20130101) Peptides C07K 14/4747 (20130101) C07K 14/5406 (20130101) Original (OR) Class C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101) C12N 5/0636 (20130101) C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048970 | Shemesh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Or A. Shemesh (Cambridge, Massachusetts); Changyang Linghu (Cambridge, Massachusetts); Kiryl D. Piatkevich (Cambridge, Massachusetts); Edward S. Boyden (Cambridge, Massachusetts); Won Min Park (Cambridge, Massachusetts) |
| ABSTRACT | The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to direct and localize sensor molecules in the soma of cells in which they are expressed. Compositions of the invention may be delivered to cells and subjects and used in methods to determine activity in cells in which they are expressed. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 17/312445 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0071 (20130101) Peptides C07K 14/705 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5091 (20130101) G01N 2500/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048971 | He et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Augusta University Research Institute, Inc. (Augusta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yukai He (Martinez, Georgia); Wei Zhu (Augusta, Georgia); Esteban Celis (Augusta, Georgia); Yibing Peng (Augusta, Georgia); Lan Wang (Augusta, Georgia) |
| ABSTRACT | T cell receptors that specifically recognize hAFP158 and methods of their use are provided. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353409 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 16/462 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048977 | Kapp et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Omniox, Inc. (San Carlos, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Kapp (San Francisco, California); Laura Serwer (Brisbane, California); Natacha Le Moan (San Francisco, California); Stephen P. L. Cary (San Mateo, California) |
| ABSTRACT | The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397577 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/41 (20130101) A61K 38/164 (20130101) A61K 45/06 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/10 (20130101) Peptides C07K 14/795 (20130101) Original (OR) Class C07K 2319/21 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) G01N 33/57407 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048978 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Dongfang Liu (Millburn, New Jersey); Minh Ma (New Brunswick, New Jersey); Saiaditya Badeti (New Brunswick, New Jersey) |
| ABSTRACT | Chimeric antigen receptors (CARs) including an antigen binding domain specifically binding to coronavirus spike protein, nucleic acids encoding the CARs, vectors including nucleic acids encoding the CARs, and immune cells expressing the CARs are provided. Methods of treating a subject with coronavirus, including administering to the subject an immune cell expressing a disclosed CAR are also provided. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399993 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) A61K 35/17 (20130101) A61K 39/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/7151 (20130101) C07K 14/70521 (20130101) C07K 16/10 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/53 (20130101) C07K 2317/56 (20130101) C07K 2317/565 (20130101) C07K 2319/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6472 (20130101) Enzymes C12Y 304/22062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048979 | Nunez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gabriel Nunez (Ann Arbor, Michigan); Jon Oscherwitz (Ann Arbor, Michigan); Kemp Cease (Ann Arbor, Michigan); Yumi Nakamura (Ann Arbor, Michigan); Tyler Nygaard (Bozeman, Montana) |
| ABSTRACT | Materials and methods are provided for treatment and/or prevention of Staphylococcal diseases and disorders such as infection and dermal inflammation. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508692 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/18 (20130101) A61K 31/37 (20130101) A61K 31/47 (20130101) A61K 31/192 (20130101) A61K 31/196 (20130101) A61K 31/235 (20130101) A61K 31/277 (20130101) A61K 31/366 (20130101) A61K 31/713 (20130101) A61K 39/40 (20130101) A61K 39/085 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/1271 (20130101) Original (OR) Class C07K 2317/34 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048980 | HICKEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RLL, LLC (Lutherville, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert J. HICKEY (Lakeview Terrace, California); Linda H. MALKAS (Lakeview Terrace, California); Lauren SCHNAPER (Lutherville, Maryland) |
| ABSTRACT | Antibodies specifically bind only to a cancer specific proliferating cell nuclear antigen (csPCNA) isoform and not to the non-malignant proliferating cell nuclear antigen (nmPCNA) isoform. Methods and compositions to detect the presence of csPCNA isoform are disclosed. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209983 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/44 (20130101) C07K 16/3015 (20130101) C07K 2317/34 (20130101) C07K 2317/73 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57496 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048987 | Andreasson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Katrin Andreasson (Stanford, California); Paras Minhas (Stanford, California) |
| ABSTRACT | In aging mice, myeloid cell bioenergetics are suppressed in response to increased signaling by the lipid messenger prostaglandin E2 (PGE2), a major modulator of inflammation. In aging macrophages and microglia, PGE2 signaling through its EP2 receptor promotes the sequestration of glucose into glycogen, reducing glucose flux and mitochondrial respiration. Inhibition of myeloid EP2 signaling restores youthful energy metabolism in peripheral macrophages and microglia, rejuvenates systemic and brain inflammatory states, and prevents loss of hippocampal synaptic plasticity and spatial memory. Blockade of peripheral myeloid EP2 signaling is sufficient to restore cognition in aged mice. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401879 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Peptides C07K 16/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048989 | Edge |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Eye and Ear Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert Edge (Brookline, Massachusetts) |
| ABSTRACT | This invention relates to methods for promoting reinnervation of auditory hair cells, specifically, by inhibiting Repulsive Guidance Molecule a (RGMa), a repulsive axonal guidance molecule that is expressed in the cochlea, or its receptor, neogenin. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332509 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/7088 (20130101) A61K 31/7105 (20130101) A61K 35/30 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) C07K 16/22 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1138 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049014 | Kufe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); GENUS ONCOLOGY, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); GENUS ONCOLOGY, LLC (Chicago, Illinois) |
| INVENTOR(S) | Donald W. Kufe (Wellesley, Massachusetts); Surender Kharbanda (Natick, Massachusetts) |
| ABSTRACT | The present invention is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494577 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) A61K 45/06 (20130101) A61K 47/6803 (20170801) A61K 47/6811 (20170801) A61K 47/6849 (20170801) A61K 47/6851 (20170801) A61K 47/6855 (20170801) A61K 47/6889 (20170801) Peptides C07K 16/2809 (20130101) C07K 16/3015 (20130101) C07K 16/3023 (20130101) C07K 16/3061 (20130101) C07K 16/3092 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/73 (20130101) C07K 2317/77 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/32 (20130101) C07K 2319/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049015 | Lyerly et al. |
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| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Herbert Lyerly (Durham, North Carolina); Zachary Hartman (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides compositions and methods for the treatment of HER2+ cancers in a subject. The present disclosure provides a combination therapy of a HER2 antibody and a CD47 antagonist. The method activate an anti-tumor response that comprises activating the antibody dependent cellular phagocytosis (ADCP) within the subject. |
| FILED | Wednesday, November 27, 2019 |
| APPL NO | 17/297821 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/70503 (20130101) C07K 16/32 (20130101) Original (OR) Class C07K 16/2803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049098 | Wagner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. Wagner (Gibsonia, Pennsylvania); Sang Ho Ye (Cheswick, Pennsylvania); Seungil Kim (Pittsburgh, Pennsylvania); Sung Kwon Cho (Pittsburgh, Pennsylvania) |
| ABSTRACT | A zwitterionic polysiloxane polymer (e.g., a polyurethane elastomer) composition having poly(dialkylsiloxane) blocks and a zwitterionic moiety is prepared by the copolymerization of a poly(dialkylsiloxane) diol, a diisocyanate, a tertiary amine alkyl diol, and a poly(dialkylsiloxane) diamine to form a poly(urethane urea) copolymer. A substituted saturated heterocylic compound is reacted with the tertiary amine of the poly(urethane urea) copolymer to introduce a zwitterionic group into the poly(urethane urea) copolymer backbone. A polysiloxane polymer having a zwitterionic moiety is prepared by reacting a diallyl tertiary amine compound and a substituted saturated heterocylic compound to form a diallyl zwitterionic macromer and cross-linking a vinyl terminated poly(dialkylsiloxane) and the diallyl zwitterionic macromer with a curing agent to introduce a zwitterionic group into the poly(dialkylsiloxane) polymer. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 17/398618 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/06 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/17 (20130101) Compositions of Macromolecular Compounds C08L 83/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049215 | Wilson |
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| FUNDED BY |
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| APPLICANT(S) | Wilson Wolf Manufacturing Corporation (New Brighton, Minnesota) |
| ASSIGNEE(S) | Wilson Wolf Manufacturing Corporation (New Brighton, Minnesota) |
| INVENTOR(S) | John R. Wilson (New Brighton, Minnesota) |
| ABSTRACT | This invention relates to methods and devices that improve cell culture efficiency. They include the use of gas permeable culture compartments that reduce the use of space while maintaining uniform culture conditions, and are more suitable for automated liquid handling. They include the integration of gas permeable materials into the traditional multiple shelf format to resolve the problem of non-uniform culture conditions. They include culture devices that use surfaces comprised of gas permeable, plasma charged silicone and can integrate traditional attachment surfaces, such as those comprised of traditional tissue culture treated polystyrene. They include culture devices that integrate gas permeable, liquid permeable membranes. A variety of benefits accrue, including more optimal culture conditions during scale up and more efficient use of inventory space, incubator space, and disposal space. Furthermore, labor and contamination risk are reduced. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/516773 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/08 (20130101) C12M 23/24 (20130101) C12M 23/34 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049221 | Shah et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts); Children`s Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dhvanit I. Shah (Chestnut Hill, Massachusetts); George Q. Daley (Weston, Massachusetts) |
| ABSTRACT | Described in the present application are methods for preparing populations of hematopoietic stem cells (HSCs), e.g., autologous and/or allogenic HSCs, using mechanical stretching or Trpv4 agonisists, and methods of use of the HSCs in transplantation. In some embodiments, the methods include providing a population comprising hemogenic endothelial (HE) cells, and (i) contacting the HE cells with an amount of an agonist of transient receptor potential cation channel-subfamily vanilloid member 4 (Trpv4); and/or (ii) subjecting the cells to cyclic 2-dimensional stretching, for a time and under conditions sufficient to stimulating endothelial-to-HSC transition. Also provided herein are methods for treating subjects who have, bone marrow, metabolic, and immune diseases; the methods include administering to the subject a therapeutically effective amount of hematopoietic stem cells (HSCs) obtained by a method described herein. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/452511 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0271 (20130101) A01K 2207/12 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 2501/999 (20130101) C12N 2506/00 (20130101) C12N 2506/28 (20130101) C12N 2506/45 (20130101) C12N 2533/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049224 | ALEXANDER et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan ALEXANDER (Shreveport, Louisiana); Mansoureh BARZEGAR (Shreveport, Louisiana); Yuping WANG (Shreveport, Louisiana) |
| ABSTRACT | Therapeutics comprising Cells and methods of creating enhanced human Placenta Mesenchymal Stem Cells (hPMSCs) comprising culturing the hPMSCs with cholesterol for one of between 24 and 96 hours and between 48 and 72 hours. Therapeutics comprising microparticles and methods of creating enhanced microparticles from hPMSCs comprising culturing the hPMSCs with cholesterol for one of between 24 and 96 hours and between 48 and 72 hours, and then separating the enhanced microparticles from the hPMSCs. Therapeutics comprising exosomes and methods of creating enhanced exosomes from hPMSCs comprising culturing the hPMSCs with cholesterol for one of between 24 and 96 hours and between 48 and 72 hours, and then separating the enhanced microparticles from the hPMSCs. Therapeutic comprising extracellular vesicles and methods of creating enhanced EVs from hPMSCs comprising culturing the hPMSCs with cholesterol for one of between 24 and 96 hours and between 48 and 72 hours. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/086315 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0668 (20130101) Original (OR) Class C12N 2500/36 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049227 | Schrepfer et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Sonja Schrepfer (Burlingame, California); Tobias Deuse (Burlingame, California) |
| ABSTRACT | The invention discloses for the first time pluripotent cells, including hypoimmune pluripotent ABO blood type O Rhesus Factor negative (HIPO−) cells, that evade rejection by the host allogeneic immune system and avoid blood antigen type rejection. The HIPO− cells comprise reduced HLA-I and HLA-II expression, increased CD47 expression, and a universal blood group O Rh− (“O−”) blood type. The universal blood type is achieved by eliminating ABO blood group A and B antigents as well as eliminating Rh factor expression, or by starting with an O− parent cell line. These new, novel HIPO− cells evade host immune rejection because they have an impaired antigen presentation capacity, protection from innate immune clearance, and lack blood group rejection. The cells of the invention also include O− pluripotent stem cells (iPSCO−) and O− embryonic stem cells (ESCO−). The invention further provides universally acceptable “off-the-shelf” pluripotent cells and derivatives thereof for generating or regenerating specific tissues and organs. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/504502 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) C12N 5/0657 (20130101) C12N 5/0696 (20130101) Original (OR) Class C12N 2500/00 (20130101) C12N 2501/115 (20130101) C12N 2501/165 (20130101) C12N 2506/02 (20130101) C12N 2506/45 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049246 | Chee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Encodia, Inc. (San Diego, California) |
| ASSIGNEE(S) | Encodia, Inc. (San Diego, California) |
| INVENTOR(S) | Mark S Chee (San Diego, California); Kevin L. Gunderson (San Diego, California); Norihito Muranaka (San Diego, California); Brian T. Weinert (San Diego, California) |
| ABSTRACT | Provided herein are methods for preparing and treating an analyte (e.g., a macromolecule or a plurality of macromolecules, peptides, polypeptides, and proteins) for analysis. In some embodiments, the analyte is prepared and treated in a method that includes the use of bait and capture nucleic acids, solid supports, and reaction mixtures including the bait and capture nucleic acids. In some embodiments, the analyte is coupled to a solid support. Also provided are kits containing components for performing the provided methods for preparing the analytes. In some embodiments, the methods are for preparing an analyte for sequencing. Provided herein are methods for preparing and treating an analyte (e.g., a macromolecule or a plurality of macromolecules, peptides, polypeptides, and proteins) for analysis. In some embodiments, the analyte is prepared and treated in a method that includes the use of bait and capture nucleic acids, solid supports, and reaction mixtures including the bait and capture nucleic acids. In some embodiments, the analyte is coupled to a solid support. Also provided are kits containing components for performing the provided methods for preparing the analytes. In some embodiments, the methods are for preparing an analyte for sequencing. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/458199 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049255 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeannie T. Lee (Boston, Massachusetts); Athanasios Zovoilis (Cambridge, Massachusetts) |
| ABSTRACT | Methods of using B2 or Alu nucleic acids, or antisense oligonucleotides that modulate the EZH2/B2 or EZH2/Alu interaction and have the capacity to alter cleavage of B2 and Alu RNA, for increasing or decreasing cell and organismal viability. |
| FILED | Wednesday, August 25, 2021 |
| APPL NO | 17/411313 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/113 (20130101) C12N 2310/314 (20130101) C12N 2310/321 (20130101) C12N 2310/341 (20130101) C12N 2310/3145 (20130101) C12N 2310/3231 (20130101) C12N 2310/3233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049276 | Doudna et al. |
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| FUNDED BY |
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| APPLICANT(S) | Emmanuelle Charpentier (Berlin, Germany); The Regents of the University of California (Oakland, California); University of Vienna (Vienna, Austria) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer A. Doudna (Berkeley, California); Martin Jinek (Berkeley, California); Krzysztof Chylinski (Vienna, Austria); Emmanuelle Charpentier (Berlin, Germany) |
| ABSTRACT | The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/481052 |
| CURRENT CPC | New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques A01H 6/4684 (20180501) Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/90 (20130101) C12N 15/102 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 15/746 (20130101) C12N 15/902 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/13 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Enzymes C12Y 301/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049281 | Koo et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sophia Koo (Brookline, Massachusetts); Horatio R. Thomas (Cambridge, Massachusetts); Lindsey R. Baden (Brookline, Massachusetts); Francisco M. Marty (Chestnut Hill, Massachusetts) |
| ABSTRACT | Methods for diagnosing, treating, and monitoring the treatment of invasive aspergillosis (IA) are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having IA. |
| FILED | Monday, April 12, 2021 |
| APPL NO | 17/228382 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/08 (20130101) A61B 5/082 (20130101) A61B 5/14546 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/04 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/497 (20130101) G01N 2800/18 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049304 | Kaminsky et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); UNIVERSITY OF MARYLAND (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary Kaminsky (Ottawa, ON, Canada); Jennifer L. Payne (Baltimore, Maryland); Todd Gould (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to the field of post-partum depression. More specifically, the present invention relates to the use of biomarkers to diagnose post-partum depression or predict a risk thereof. In a specific embodiment, a method for identifying a likelihood of PPD in a patient comprises the steps of (a) providing a sample from the patient; (b) measuring white blood cell type counts and DNA methylation levels of a panel of biomarkers in the sample collected from the patient, wherein the panel of biomarkers comprises HP1BP3 and TTC9B and the white blood cell type counts comprise monocytes and non-monocytes; and (c) identifying the patient as likely to develop PPD based on the relative DNA methylation levels at the biomarker loci relative to the ratio of monocytes:non-monocytes. |
| FILED | Tuesday, August 11, 2020 |
| APPL NO | 16/990572 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/118 (20130101) C12Q 2600/154 (20130101) C12Q 2600/158 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050096 | Lakowicz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University Of Maryland, Baltimore (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph R. Lakowicz (Ellicot City, Maryland); Ramachandram Badugu (Ellicott City, Maryland); E. Albert Reece (Lutherville, Maryland) |
| ABSTRACT | A probe compound, contact lens containing bound probe, and method are disclosed for use in detecting analytes in basal tears on the surface of the eye of a subject. The probe composition preferably includes a hydrophilic portion, an analyte-sensitive portion and a fluorophore portion as well as a hydrophobic portion that allows binding to the contact lens material and optionally can modify the binding affinity of the fluorophore probe. The analyte-sensitive portion is configured to bind to a specific analyte in aqueous solution or to be quenched by the analyte. The fluorophore portion is configured to change an optical property of fluorescent light emitted in response to incident excitation light when the probe composition changes between a first state in which the analyte is not bound to the analyte-binding portion and a second state in which the analyte binds to the analyte-binding portion. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/402092 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/6821 (20130101) A61B 5/14507 (20130101) A61B 5/14546 (20130101) A61B 2562/0233 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/52 (20130101) Original (OR) Class G01N 2800/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050106 | Ball et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Quanterix Corporation (Billerica, Massachusetts) |
| ASSIGNEE(S) | Quanterix Corporation (Billerica, Massachusetts) |
| INVENTOR(S) | Andrew Ball (Billerica, Massachusetts); Lei Chang (Billerica, Massachusetts); Syrena Fernandes (Billerica, Massachusetts); Kevin Hrusovsky (Billerica, Massachusetts); Joseph Johnson (Billerica, Massachusetts); Dawn Mattoon (Billerica, Massachusetts); Tatiana Plavina (Billerica, Massachusetts); Dandan Shan (Billerica, Massachusetts); David Wilson (Billerica, Massachusetts) |
| ABSTRACT | The present disclosure relates to methods and compositions, e.g., kits, for assessing or detecting SARS-CoV-2 antigen(s), e.g., SARS-CoV-2 nucleocapsid protein (N-protein), in a sample or a blood sample, e.g., serum, plasma, dried blood spots (DBS) and/or a saliva sample. Certain applications and uses of the present methods and compositions, e.g., kits, are also provided. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/400086 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54366 (20130101) G01N 33/56983 (20130101) Original (OR) Class G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050112 | Hergenrother et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Paul J. Hergenrother (Champaign, Illinois); Bryon S. DROWN (Champaign, Illinois) |
| ABSTRACT | The post-translational modification (PTM) and signaling molecule poly(ADP-ribose) (PAR) has an impact on diverse biological processes. PTM is regulated by a series of ADP-ribosyl glycohydrolases (PARG enzymes) that cleave polymers and/or liberate monomers from their protein targets. Disclosed herein is a substrate for monitoring PARG activity, TFMU-ADPr, which directly reports on total PAR hydrolase activity via release of a fluorophore; this substrate has excellent reactivity, generality, stability, and usability. A second substrate, TFMU-IDPr, selectively reports on PARG activity only from the enzyme ARH3. Use of these probes in whole-cell lysate experiments has revealed a mechanism by which ARH3 is inhibited by cholera toxin. TFMU-ADPr and TFMU-IDPr are versatile tools for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes. |
| FILED | Monday, September 09, 2019 |
| APPL NO | 17/274395 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1022 (20130101) C09K 2211/1059 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 33/582 (20130101) Original (OR) Class G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050279 | Grunwald et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Grunwald (Worcester, Massachusetts); Maximiliaan Huisman (North Brookfield, Massachusetts) |
| ABSTRACT | The invention provides for a system and methods of directly delivering excitation light to a sample by a path that avoids traveling though the objective and dichroic mirror. Certain embodiments of the system may include an excitation light source, and a series of mirrors and lenses to direct the excitation light to a diffuser unit. The diffuser unit may then generate a configurable illumination profile to evenly illuminate a sample. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/274627 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) Original (OR) Class G02B 21/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050280 | Glaser et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Adam K. Glaser (Seattle, Washington); Jonathan T.C. Liu (Seattle, Washington); Nicholas Reder (Seattle, Washington) |
| ABSTRACT | Apparatuses, systems, and methods for modular sample holders. The microscope may direct illumination light along an illumination path towards a sample and collect light from the sample along a collection path. Light along the illumination path may pass through an immersion fluid and the material of the sample holder to reach the sample. Light along collection path may pass through the material of the sample holder and the immersion fluid. The sample holder may have a first optical surface along the illumination path which is generally perpendicular to an optical axis of the illumination path. The sample holder may have a second optical surface along the collection path which is generally perpendicular to an optical axis of the collection path. The sample holder may be modular. The sample holder may contain the sample in an enclosed channel. |
| FILED | Wednesday, February 12, 2020 |
| APPL NO | 17/310309 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) Original (OR) Class G02B 21/26 (20130101) G02B 21/33 (20130101) G02B 21/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050282 | Grunwald et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Grunwald (Worcester, Massachusetts); Maximiliaan Huisman (North Brookfield, Massachusetts); Karina Jouravleva (Worcester, Massachusetts); Carlas Smith (Delft, Netherlands); Phillip D. Zamore (Northborough, Massachusetts) |
| ABSTRACT | The invention is directed to a heated stage assembly that can achieve high temperatures (i.e., 40 degrees Celsius and higher and more specifically, 55 degrees Celsius and higher) for use in microscopy including fluorescence microscopy. The microscope stage heater assembly includes a mounting adapter element, a sample holder element mounted within the mounting adapter element, one or more heating elements attached to the sample holder element, and an optical window holder element disposed on a surface of the sample holder element that encloses an optical window element. The optical window element may be in contact with a microscope sample such that the optical window element is heated by the sample holder element to uniformly distribute heat to the specimen. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/274625 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) G02B 21/26 (20130101) G02B 21/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220051431 | JAGADEESAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jayender JAGADEESAN (Boston, Massachusetts); Haoyin ZHOU (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for creating images of an environment includes controlling at least one camera to acquire imaging data from the environment and selecting, from the imaging data, a three-dimensional-two-dimensional correspondence as a control point for use in a perspective-n-point problem to determine a position and orientation of the at least one camera from n known correspondences between three-dimensional object points and their two-dimensional image projections in the environment. The method also includes reprojecting at least a selected number of the projections, determining a reprojection error for each of the projections, and performing a weight assignment of reprojection errors to distinguish the inliers form outliers. These steps of the method are repeated to apply the weight assignment to outliers in a decreased fashion during iterations to reduce an impact of outliers in the real-time display of the environment. |
| FILED | Tuesday, December 17, 2019 |
| APPL NO | 17/414640 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/73 (20170101) Original (OR) Class G06T 17/00 (20130101) G06T 2207/10021 (20130101) G06T 2207/10056 (20130101) G06T 2207/10068 (20130101) G06T 2207/30004 (20130101) G06T 2207/30244 (20130101) Pictorial Communication, e.g Television H04N 13/204 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220051455 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Ge Wang (Loudonville, New York); Wenxiang Cong (Albany, New York) |
| ABSTRACT | A machine-learning-based monochromatic CT image reconstruction method is described for quantitative CT imaging. The neural network is configured to learn a nonlinear mapping function from a training data set to map a CT image, which is reconstructed from a single spectral current-integrating projection data set, to monochromatic projections at a pre-specified energy level, realizing monochromatic CT imaging and overcoming beam hardening. An apparatus, method and/or system are configured to determine, by a trained artificial neural network (ANN), a monochromatic projection data set based, at least in part, on a measured CT image. The measured CT image may be reconstructed based, at least in part, on measured projection data. The measured projection data may be polychromatic. The apparatus, method and/or system may be further configured to reconstruct a monochromatic CT image based, at least in part, on the monochromatic projection data set. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/460470 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Image Data Processing or Generation, in General G06T 11/006 (20130101) Original (OR) Class G06T 2207/10081 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220051752 | Baker et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Baker (South Bend, Indiana); Tim Riley (South Bend, Indiana) |
| ABSTRACT | Disclosed herein are methods for predicting immunogenicity of a candidate peptide. The method comprises obtaining a three-dimensional candidate structural representation of the candidate peptide bound to an antigen presenting molecule; obtaining a plurality of candidate measurements; and predicting, with an electronic processor, the immunogenicity of the candidate peptide based upon the plurality of candidate measurements. Further disclosed herein are methods for producing vaccines. The method for producing a vaccine comprises predicting immunogenicity of one or more candidate peptides using the methods described herein, and producing a vaccine comprising one or more peptides predicted to be immunogenic. |
| FILED | Friday, December 06, 2019 |
| APPL NO | 17/312134 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/00 (20190201) Original (OR) Class G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220047859 | Nejad et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hojatollah Rezaei Nejad (Boston, Massachusetts); Aydin Sadeqi (Boston, Massachusetts); Sameer Sonkusale (Boston, Massachusetts) |
| ABSTRACT | Systems and methods for creating microneedle arrays capable of delivering a suitable drug dosages to subjects are provided. In one aspect, a method comprises creating at least one forming mold using laser ablation in a cross-over line pattern. The method further comprises casting a first material onto the at least one forming mold to create at least one microneedle mold. The method further comprises casting a second material onto the at least one microneedle mold to create at least one hollow microneedle. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461165 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0015 (20130101) Original (OR) Class A61M 2037/0046 (20130101) A61M 2037/0053 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 33/405 (20130101) B29C 33/3842 (20130101) B29C 39/02 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/7544 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048002 | Stroud et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy Arlingto (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Rhonda M. Stroud (Washington, District of Columbia); Matthew J. Crane (Seattle, Washington); Peter J. Pauzauskie (Seattle, Washington) |
| ABSTRACT | A method of making molecularly doped nanodiamond. A versatile method for doping diamond by adding dopants into a carbon precursor and producing diamond at high pressure, high temperature conditions. Molecularly doped nanodiamonds that have direct incorporation of dopants and therefore without the need for ion implantation. Molecularly-doped diamonds that have fewer lattice defects than those made with ion implantation. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/512929 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 3/062 (20130101) Original (OR) Class B01J 13/0091 (20130101) B01J 2203/062 (20130101) B01J 2203/0625 (20130101) B01J 2203/0655 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/26 (20170801) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/52 (20130101) C01P 2002/82 (20130101) C01P 2002/84 (20130101) C01P 2004/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048110 | Sherman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Powdermet, Inc. (Euclid, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Sherman (Mentor, Ohio); Brian Doud (Euclid, Ohio) |
| ABSTRACT | A syntactic metal foam composite that is substantially fully dense except for syntactic porosity is formed from a mixture of ceramic microballoons and matrix forming metal. The ceramic microballoons have a uniaxial crush strength and a much higher omniaxial crush strength. The mixture is continuously constrained while it is consolidated. The constraining force is less than the omniaxial crush strength. The substantially fully dense syntactic metal foam composite is then constrained and deformation worked at a substantially constant volume. The deformation working is typically performed at a yield strength that is adjusted by way of selecting a working temperature at which the yield strength is approximately less than the omniaxial crush strength of the included ceramic microballoons. This deformation causes at least work hardening and grain refinement in the matrix metal. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513374 |
| CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 31/00 (20130101) Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/16 (20130101) B22F 3/1112 (20130101) Original (OR) Class B22F 2003/1106 (20130101) B22F 2998/10 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 5/16 (20130101) B32B 5/18 (20130101) B32B 5/20 (20130101) Alloys C22C 1/1084 (20130101) C22C 32/0031 (20130101) C22C 32/0036 (20130101) C22C 32/0078 (20130101) C22C 49/00 (20130101) C22C 49/06 (20130101) C22C 49/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048147 | Bafna et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (, None) |
| INVENTOR(S) | Sudhir Bafna (Tucson, Arizona); David R. Smith (Green Valley, Arizona); Kohl Leger (Sahuarita, Arizona); Read L. Bryant (Tucson, Arizona) |
| ABSTRACT | A separable component assembly is disclosed. The separable component assembly can include a first component having a first interface portion. The separable component assembly can also include a second component coupled to the first component. The second component can have a second interface portion. In addition, the separable component assembly can include a seal disposed between the first and second interface portions. The seal can have a first interface surface associated with the first interface portion. The seal can also have a second interface surface in contact with the second interface portion. Additionally, the seal can have a peel initiator defining a discontinuity in a portion of the second interface surface. Upon separation of the first and second components from one another, the discontinuity can create a stress concentration in the second interface surface that initiates peeling of the second interface surface away from the second interface portion. |
| FILED | Monday, August 17, 2020 |
| APPL NO | 16/995737 |
| CURRENT CPC | Metal-working Not Otherwise Provided For; Combined Operations; Universal Machine Tools B23P 19/04 (20130101) Original (OR) Class Pistons; Cylinders; Sealings F16J 15/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048255 | Iliopoulos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Athanasios Iliopoulos (Bethesda, Maryland); John G. Michopoulos (Washington, District of Columbia); John C. Steuben (Washington, District of Columbia); Benjamin D. Graber (College Park, Maryland); Andrew J. Birnbaum (Washington, District of Columbia) |
| ABSTRACT | An additive manufacturing device includes a container bed configured to contain material powder; a printing bed over which material is deposited and heat applied; one or more heating elements configured to hold material on the printing bed and material on the container bed at temperatures higher than ambient; one or more actuators; and a two-dimensional array of heat deposition devices configured for a 2D space filling movement by the one or more actuators in a plane generally perpendicular to an optical axis of the heat deposition devices. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403798 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/85 (20210101) B22F 12/41 (20210101) B22F 12/45 (20210101) B22F 12/47 (20210101) B22F 12/224 (20210101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) B29C 64/236 (20170801) B29C 64/268 (20170801) B29C 64/282 (20170801) B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220048764 — BROADBAND ACHROMATIC POLARIZATION-INSENSITIVE METALENS WITH ANISOTROPIC NANOSTRUCTURES
| US 20220048764 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Wei-Ting CHEN (Cambridge, Massachusetts); Alexander Yutong ZHU (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | Polarization-insensitive metasurfaces using anisotropic nanostructures are disclosed. These anisotropic structures allow for an accurate implementation of phase, group delay, and group delay dispersion, while simultaneously making it possible to realize a polarizationinsensitive, diffraction-limited and achromatic metalens for wavelength, e.g., λ=from about 460 nm to about 700 nm. The approach of polarization-insensitivity can be also applied for other metasurface devices with applications in, e.g., imaging and virtual or augmented reality. |
| FILED | Tuesday, September 24, 2019 |
| APPL NO | 17/279060 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Original (OR) Class B82Y 40/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 5/1814 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048863 | Shen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | City of Hope (Duarte, California); California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Binghui Shen (La Verne, California); Judith Campbell (Pasadena, California); Li Zheng (Arcadia, California); Hongzhi Li (Duarte, California); David Horne (Duarte, California); Jun Xie (Duarte, California); Kenneth Karanja (Maple Grove, Minnesota) |
| ABSTRACT | Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/515252 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 215/56 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048870 | Piercey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Davin Glenn Piercey (Lafayette, Indiana); Dominique Wozniak (Lafayette, Indiana) |
| ABSTRACT | The present disclosure relates to a novel compound suitable for a metal-free primary explosive, and the method of making and using the novel compound. The novel compound can undergo a deflagration to detonation transition (DDT) to initiate detonation of a larger body of secondary explosive. The compound has a structure of Formula I: |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/221866 |
| CURRENT CPC | Explosives or Thermic Compositions; Manufacture Thereof; Use of Single Substances as Explosives C06B 25/00 (20130101) Heterocyclic Compounds C07D 249/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048934 | Chaloux et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian L. Chaloux (Alexandria, Virginia); Albert Epshteyn (Potomac, Maryland); Thomas J. Dabrow (College Park, Maryland) |
| ABSTRACT | Described herein is the preparation of carbon phosphonitride pre-polymers that are soluble in organic solvents and can be further thermoset into carbon phosphonitride extended solids (i.e. films, monoliths, etc.) with an approximate empirical formula of C3N3P. |
| FILED | Tuesday, July 27, 2021 |
| APPL NO | 17/443750 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/5036 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049015 | Lyerly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Herbert Lyerly (Durham, North Carolina); Zachary Hartman (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides compositions and methods for the treatment of HER2+ cancers in a subject. The present disclosure provides a combination therapy of a HER2 antibody and a CD47 antagonist. The method activate an anti-tumor response that comprises activating the antibody dependent cellular phagocytosis (ADCP) within the subject. |
| FILED | Wednesday, November 27, 2019 |
| APPL NO | 17/297821 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/70503 (20130101) C07K 16/32 (20130101) Original (OR) Class C07K 16/2803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049081 | Reed et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julian H. Reed (Champaign, Illinois); Donald M. Cropek (Champaign, Illinois) |
| ABSTRACT | In one embodiment, a hydrogel-enzyme construct for performing high temperature enzymatic reaction on paraoxon, and/or for performing enzymatic reaction on paraoxon following exposure to high temperature, includes a hydrogel having multiple layers of poly(methacrylic acid) (PMAA) and a plurality of dPTE2 enzyme molecules. Individual dPTE2 enzyme molecules are embedded between adjacent PMAA layers and are covalently bonded with respective individual PMAA layers. The hydrogel-enzyme construct is capable of performing enzymatic reaction on the paraoxon when the paraoxon is exposed to the hydrogel-enzyme construct under a temperature condition of up to above 99° C. and below 100° C. or when the paraoxon is exposed to the hydrogel-enzyme construct after the hydrogel-enzyme construct has been heated to a temperature condition of up to 550° C., where the enzymatic reaction on the paraoxon by individual dPTE2 molecules embedded within the hydrogel occurs at a residual activity of between 20% and 100%. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397967 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 33/10 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) Enzymes C12Y 301/08001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049214 | GURTNER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Geoffrey C. GURTNER (Portola Valley, California); Jayakumar RAJADAS (Cupertino, California); Robert C. RENNERT (Palo Alto, California); Dominik DUSCHER (Linz, Austria) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Geoffrey C. GURTNER (Portola Valley, California); Jayakumar RAJADAS (Cupertino, California); Robert C. RENNERT (Palo Alto, California); Dominik DUSCHER (Linz, Austria) |
| ABSTRACT | Efficient stem cell delivery into biomaterials using capillary driven encapsulation are disclosed herein where stem/progenitor and/or tissue specific cells are rapidly and efficiently seeded via capillary driven encapsulation into a porous scaffold for cell delivery in the skin or any other organ. The rapid capillary force approach maximizes both seeding time and efficiency by combining hydrophobic, entropic and capillary forces to promote active, ‘bottom-up’ cell engraftment. This methodology uses micro domain patterned biopolymers in a porous dry gel to generate capillary pressure to move a viscous stem cell mix from a hydrophobic reservoir into the polymer matrix to promote active cell seeding within the entire gel volume. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513200 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) Original (OR) Class C12N 2527/00 (20130101) C12N 2533/30 (20130101) C12N 2533/54 (20130101) C12N 2533/70 (20130101) C12N 2535/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049242 | ISMAGILOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rustem ISMAGILOV (Altadena, California); Erik JUE (Pasadena, California); Daan WITTERS (San Diego, California) |
| ABSTRACT | Methods and systems and related compositions for separating through a solid matrix a mixture comprising a nucleic acid together with a target compound having a water solubility equal to or greater than 0.01 mg per 100 mL, which can be used for managing fluid flow, biochemical reactions and purification of the nucleic acid or other target analytes. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511235 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/508 (20130101) B01L 3/50851 (20130101) B01L 3/502753 (20130101) B01L 7/52 (20130101) B01L 2200/0631 (20130101) B01L 2200/0689 (20130101) B01L 2300/04 (20130101) B01L 2300/18 (20130101) B01L 2300/069 (20130101) B01L 2300/0672 (20130101) B01L 2400/0605 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1003 (20130101) Original (OR) Class C12N 15/1006 (20130101) C12N 15/1013 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6456 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049358 | Heigl et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PPG Industries Ohio, Inc. (C;leveland, Ohio) |
| ASSIGNEE(S) | PPG Industries Ohio, Inc. (Cleveland, Ohio) |
| INVENTOR(S) | Julia Heigl (Butler, Pennsylvania); Nicole Lynn Rakers (Delmont, Pennsylvania); Mark W. McMillen (Cabot, Pennsylvania); Kees Van der Kolk (Uitgeest, Netherlands); Arif Mubarok (Allison Park, Pennsylvania); Daniel Connor (Evans City, Pennsylvania); Melinda J. Shearer (Pittsburgh, Pennsylvania); Mary Lyn C. Lim (Allison Park, Pennsylvania) |
| ABSTRACT | The present invention is directed to a particle having a chemical conversion coating on at least a portion of the particle surface. The present invention is further directed to a coated substrate comprising: (a) a surface that has been contacted with a particle having a chemical conversion coating on at least a portion of the particle surface such that at least some portion of the substrate becomes treated with the conversion coating. |
| FILED | Wednesday, December 04, 2019 |
| APPL NO | 17/311030 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/02 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 22/12 (20130101) Original (OR) Class C23C 22/73 (20130101) C23C 22/78 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049442 | Johnson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | August N Johnson (Raymond, Mississippi); Bowen G Woodson (Clinton, Mississippi); Austin C Hopkins (Vicksburg, Mississippi) |
| ABSTRACT | In one embodiment, a deployable barrier container apparatus includes: in folded position, a container and, in unfolded position, a vertical barrier component is deployable on a base placed on the ground to oppose vehicle traffic approaching from an upstream side, a second side wall and a ceiling top are disposed on the downstream side of the base, a first side wall and a stowed top are disposed on the upstream side of the base and on which approaching vehicles move, the horizontal barrier component is disposed upstream of the stowed top and on which the approaching vehicles move, and the horizontal barrier component comprises an elongated sliding friction mat which creates a sliding friction interface with the ground upon contact of a moving vehicle with the deployed vertical barrier component in the deployed position. The base, side walls, and tops are rotatably connected to unfold to form the barrier apparatus. |
| FILED | Tuesday, August 11, 2020 |
| APPL NO | 16/990692 |
| CURRENT CPC | Additional Work, Such as Equipping Roads or the Construction of Platforms, Helicopter Landing Stages, Signs, Snow Fences, or the Like E01F 13/123 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049614 | Baldiga et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan D. Baldiga (Lynn, Massachusetts); David W. Bogdan (Lynn, Massachusetts) |
| ABSTRACT | Example apparatus, systems, and articles of manufacture to control deflection mismatch are disclosed herein. Further examples and combinations thereof include: A deflection limiter comprising an inner shroud segment to support a stator structure, the inner shroud segment including a first end face and a first outer upper portion, the first end face positioned radially inward and aft relative to the first outer upper portion, and an outer shroud segment to support the inner shroud segment, the outer shroud segment including a second end face and a second outer upper portion, the second end face positioned aft relative to the first end face and the second outer upper portion positioned aft relative to the first outer upper portion of the inner shroud segment, the second end face coupled to the first end face of the inner shroud segment and the second outer upper portion coupled to the first outer upper portion. |
| FILED | Monday, August 17, 2020 |
| APPL NO | 16/995467 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/12 (20130101) F01D 9/00 (20130101) F01D 11/22 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2240/11 (20130101) F05D 2240/12 (20130101) F05D 2240/55 (20130101) F05D 2240/60 (20130101) F05D 2270/303 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049977 | Claytor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin E. Claytor (Columbia, Maryland); David M. Hull (Adelphi, Maryland) |
| ABSTRACT | A non-contact power meter system for measuring power in an energized cable is provided. It includes: at least one electric field sensor; a plurality of magnetic field sensors, wherein the at least two magnetic field sensors together are configured to measure a magnetic field in a tangential direction and a radial direction with respect the energized cable measured; and a processor, which receives measurement signals from the various sensors, and is configured to measure power in the energized cable. A method of determining twist in an energized cable using non-contact power meter system(s) is also provided. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 16/992174 |
| CURRENT CPC | Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/145 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 21/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050012 | Redding et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon F. Redding (University Park, Maryland); Joseph B. Murray (Ellicott City, Maryland) |
| ABSTRACT | Brillouin fiber sensors can provide distributed measurements of parameters of interest over long distances in a fiber by measuring the Brillouin frequency shift as a function of position along the fiber. The Brillouin frequency shift may be determined, to within a small fraction of the Brillouin linewidth, by establishing a series of lasing modes that experience Brillouin amplification at discrete spatial locations in a test fiber. A linewidth narrowing and high intensity associated with the lasing transition enable precise measurements of the lasing frequency associated with each of the lasing modes. The Brillouin frequency may be determined based on the lasing frequency. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/400107 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 11/3109 (20130101) Original (OR) Class Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/302 (20130101) H01S 3/08036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050043 | Ozdemir et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sahin Kaya Ozdemir (St. Louis, Missouri); Lan Yang (St. Louis, Missouri); Bo Peng (St. Louis, Missouri); Faraz Monifi (San Diego, California) |
| ABSTRACT | An a system and method for chaos transfer between multiple detuned signals in a resonator mediated by chaotic mechanical oscillation induced stochastic resonance where at least one signal is strong and where at least one signal is weak and where the strong and weak signal follow the same route, from periodic oscillations to quasi-periodic and finally to chaotic oscillations, as the strong signal power is increased. |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/446525 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) Original (OR) Class G01N 21/7746 (20130101) G01N 2021/655 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050140 | DICKENS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GRAMMATECH, INC. (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Alvin DICKENS (Newfield, New York) |
| ABSTRACT | Systems, methods, and computer readable medium described herein relate to techniques for characterizing and/or anomaly detection in integrated circuits such as, but not limited to, field programmable gate arrays (FPGAs) and application-specific integrated circuits (ASICs). In one example aspect of certain example embodiments, a fully digital technique relies on the pulse width of signals propagated through a path under test. In another example aspect, the re-configurability of the integrated circuit is leveraged to combine the pulse propagation technique with a delay characterization technique to yield better detection of certain type of Trojans and the like. Another example aspect provides for running the test through reconfigurable path segments in order to isolate and identify anomalous circuit elements. Yet another example aspect provides for performing the characterization and anomaly detection without requiring golden references and the like. |
| FILED | Monday, August 09, 2021 |
| APPL NO | 17/397417 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/3177 (20130101) G01R 31/31706 (20130101) G01R 31/31725 (20130101) G01R 31/318519 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050215 | Weighton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James K. Weighton (Central City, Iowa); Kenneth Cogan (Cedar Rapids, Iowa); Benjamin Graubard (Alburnett, Iowa); Troy V. Mundt (North Liberty, Iowa); Jimmey Stultz (Cedar Rapids, Iowa); Meraj Choudhury (Cedar Rapids, Iowa) |
| ABSTRACT | A navigation satellite receiver system is disclosed. The system includes a host receiver. The host receiver includes a user interface, a module connector, and a controller coupled to the user interface and the module connector. The system further includes a receiver module operably coupled to the receiver module. The receiver module includes an antenna configured to receive one or more satellite navigation signal. The receiver module further includes an interface receiver card operably coupled to the module antenna. The interface receiver card is configured to process the one or more navigation signals. The receiver module further includes a host connector communicatively coupled to the interface receiver card and is configured to couple to the module connector. The module includes a housing configured to receive and protect the interface receiver card, the antenna, and the host connector. |
| FILED | Wednesday, August 12, 2020 |
| APPL NO | 16/991898 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/10 (20130101) G01S 19/36 (20130101) G01S 19/37 (20130101) Original (OR) Class Antennas, i.e Radio Aerials H01Q 1/241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050280 | Glaser et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Adam K. Glaser (Seattle, Washington); Jonathan T.C. Liu (Seattle, Washington); Nicholas Reder (Seattle, Washington) |
| ABSTRACT | Apparatuses, systems, and methods for modular sample holders. The microscope may direct illumination light along an illumination path towards a sample and collect light from the sample along a collection path. Light along the illumination path may pass through an immersion fluid and the material of the sample holder to reach the sample. Light along collection path may pass through the material of the sample holder and the immersion fluid. The sample holder may have a first optical surface along the illumination path which is generally perpendicular to an optical axis of the illumination path. The sample holder may have a second optical surface along the collection path which is generally perpendicular to an optical axis of the collection path. The sample holder may be modular. The sample holder may contain the sample in an enclosed channel. |
| FILED | Wednesday, February 12, 2020 |
| APPL NO | 17/310309 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) Original (OR) Class G02B 21/26 (20130101) G02B 21/33 (20130101) G02B 21/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220051053 | De La Houssaye et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States Government as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul R. De La Houssaye (San Diego, California); Benjamin J. Migliori (Santa Fe, New Mexico); Adi Ratan Bulsara (San Diego, California); Chriswell Hutchens (San Diego, California); Justin M. Mauger (San Diego, California) |
| ABSTRACT | A pattern recognition device comprising: a coupled network of damped, nonlinear, dynamic elements configured to generate an output response in response to at least one environmental condition, wherein each element has an associated multi-stable potential energy function that defines multiple energy states of an individual element, and wherein the elements are tuned such that environmental noise triggers stochastic resonance between energy levels of at least two elements; a processor configured to monitor the output response over time and to determine a probability that the pattern recognition device is in a given state based on the monitored output response; and detecting a pattern in the at least one environmental condition based on the probability. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/384338 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00986 (20130101) G06K 9/6248 (20130101) Original (OR) Class G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220051565 | Hui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Leo Ho Chi Hui (Alhambra, California); Haig Francis Krikorian (Fullerton, California) |
| ABSTRACT | A computer-implemented method performed by a centralized coordinated vehicle guidance system may include: obtaining analytics data for a plurality of vehicles or objects centrally communicating with or detected by the centralized coordinated vehicle guidance system; detecting, based on the analytics data, a collision event within one or more vehicle-object pairs; determining trajectory adjustment information for one or more vehicle in the vehicle-object pairs involved in the collision event; and outputting the trajectory adjustment information to cause the vehicle to modify its trajectory. |
| FILED | Friday, June 18, 2021 |
| APPL NO | 17/352075 |
| CURRENT CPC | Traffic Control Systems G08G 1/052 (20130101) G08G 1/056 (20130101) G08G 1/0133 (20130101) G08G 1/164 (20130101) Original (OR) Class G08G 1/166 (20130101) G08G 1/096725 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220051566 | Hui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Leo Ho Chi Hui (Alhambra, California); Haig Francis Krikorian (Fullerton, California) |
| ABSTRACT | A computer-implemented method performed by a centralized coordinated vehicle guidance system may include: obtaining analytics data for a plurality of vehicles or objects centrally communicating with or detected by the centralized coordinated vehicle guidance system; detecting, based on the analytics data, a predicted collision event involving multiple pairs of the plurality of vehicles or objects; determining trajectory adjustment information for a first vehicle of the plurality of vehicles involved in the collision event; and outputting the trajectory adjustment information to cause the first vehicle to modify its trajectory. |
| FILED | Friday, June 18, 2021 |
| APPL NO | 17/352144 |
| CURRENT CPC | Traffic Control Systems G08G 1/052 (20130101) G08G 1/056 (20130101) G08G 1/0133 (20130101) G08G 1/164 (20130101) Original (OR) Class G08G 1/166 (20130101) G08G 1/096725 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220051651 | Yeboah |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Department of the Army (, None) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jackson Yeboah (Fort Bragg, North Carolina) |
| ABSTRACT | An advanced acoustic awareness platform configured to classify environmental sounds. The advanced acoustic awareness platform comprises an audio signal acquisition sensor array and one or more processors programmed to augment the audio signal, extract features for the audio signal, visualize, and classify the signal using one or more labels. In at least one embodiment, the signal is classified based on transfer learning associated with a pretrained machine learning model. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401667 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/22 (20130101) B64C 2201/162 (20130101) B64C 2220/00 (20130101) Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 11/1785 (20180101) Original (OR) Class G10K 2210/1281 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220051894 | Muratore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Christopher Muratore (Dayton, Ohio); Michael E. McConney (Beavercreek, Ohio); Travis E. Shelton (Dayton, Ohio); Nicholas R. Glavin (Beavercreek, Ohio); John E. Bultman (Huber Heights, Ohio); Andrey A. Voevodin (Dayton, Ohio) |
| ASSIGNEE(S) | University of Dayton (Dayton, Ohio) |
| INVENTOR(S) | Christopher Muratore (Dayton, Ohio); Michael E. McConney (Beavercreek, Ohio); Travis E. Shelton (Dayton, Ohio); Nicholas R. Glavin (Beavercreek, Ohio); John E. Bultman (Huber Heights, Ohio); Andrey A. Voevodin (Dayton, Ohio) |
| ABSTRACT | Methods of making molybdenum sulfide (MoS2) on a stretchable substrate are disclosed. The method includes magnetron sputtering MoS2 onto a stretchable substrate, such as a stretchable polymeric material, at low temperatures to form a film precursor, and illumination annealing the film precursor to form high quality MoS2. The illumination source may be a laser or other source of radiation. Also, two-dimensional nanoelectronic devices made by the methods and/or from the high quality MoS2 are disclosed. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403265 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02422 (20130101) H01L 21/02485 (20130101) H01L 21/02568 (20130101) H01L 21/02631 (20130101) H01L 21/02675 (20130101) Original (OR) Class H01L 29/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052365 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zhongyang Wang (St. Louis, Missouri); Vijay K. Ramani (St. Louis, Missouri); Shrihari Sankarasubramanian (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Zhongyang Wang (St. Louis, Missouri); Vijay K. Ramani (St. Louis, Missouri); Shrihari Sankarasubramanian (St. Louis, Missouri) |
| ABSTRACT | Described herein are direct liquid fuel cells with an alkaline anodic fuel stream including a solution of liquid fuel such as alcohols, ethers, glycols or compounds of hydrazine, and an acidic cathode oxidant stream including a solution of a suitable oxidant such as hydrogen peroxide or a gas steam with 1% to 100% O2. These cells are used as primary stationary and/or mobile power sources and also function in a secondary role as range extenders when coupled with a primary power source. |
| FILED | Tuesday, October 27, 2020 |
| APPL NO | 17/081174 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/926 (20130101) H01M 4/8892 (20130101) H01M 8/083 (20130101) Original (OR) Class H01M 8/1004 (20130101) H01M 2004/8694 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052368 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peiwen Li (Tucson, Arizona); Xinhai Xu (Tucson, Arizona); Shuyang Zhang (Tucson, Arizona); Xiaoxin Wang (Tucson, Arizona) |
| ABSTRACT | A novel electrochemical hydrogen compressor material technology system comprising a composite polymer membrane made from a blend of inorganic and organic polymers, the preparation and the use thereof. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/221744 |
| CURRENT CPC | Positive-displacement Machines for Liquids; Pumps F04B 43/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/92 (20130101) H01M 4/8605 (20130101) H01M 8/0258 (20130101) H01M 8/0267 (20130101) H01M 8/1213 (20130101) Original (OR) Class H01M 8/04029 (20130101) H01M 8/04074 (20130101) H01M 2008/1095 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052388 | Fortier |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aleksandra Fortier (Coppell, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aleksandra Fortier (Coppell, Texas) |
| ABSTRACT | The disclosed principles provide for techniques for the 3D fabrication of sensing systems that are embedded inside battery cells and provide cell parameter data for a comprehensive and an robust battery management system. The disclosed principles provide for online and real-time monitoring of battery state-of-health down to the individual cell level of each battery using embedded sensors on one or more of the internal layers of a cell, such as the dielectric separators found in such battery cells. The implementation of the disclosed principles in individual battery cells therefore provides an increased likelihood to mitigate catastrophic failures in batteries. In addition, the disclosed fabrication processes for printing sensors directly on one or more of the components or layers within each individual battery cell, significantly reduce manufacturing steps required by conventional battery management systems. The disclosed principles also provided for a unique silica-based ink for use in the 3D printing of such embedded cell sensing components. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403726 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/48 (20130101) Original (OR) Class H01M 10/486 (20130101) H01M 2010/4278 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052835 | Eldefrawy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karim Eldefrawy (Palo Alto, California); Tancrède Lepoint (New York, New York) |
| ABSTRACT | Systems and methods for selectively sharing of portion of unstructured data containers/documents based on security attributes or policies used to encrypt/decrypt data within the unstructured data containers using standard encryption schemes are provided herein. In some embodiments, a system includes a key generation authority to generate encryption keys based on a selected cryptographic security scheme and one or more security attributes or security policies; an encryption service to selectively encrypt one or more data subgroups using the one or more public keys and based on one or more security attributes or security policies assigned to the one or more data subgroups with the unstructured data containers; and a decryption service to decrypt the one or more data subgroups within unstructured data containers using the one or more secret keys and the one or more public keys. |
| FILED | Wednesday, November 11, 2020 |
| APPL NO | 17/095324 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/31 (20190101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0618 (20130101) Original (OR) Class H04L 9/0819 (20130101) H04L 9/0861 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052959 | ROSEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The MITRE Corporation (Mclean, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | Andrew ROSEN (Westford, Massachusetts); Chelsea GEORGAN (Cambridge, Massachusetts); Jon AHO (Somerville, Massachusetts); Venkatesh RAMASWAMY (Westford, Massachusetts) |
| ABSTRACT | A system for establishing and maintaining a communications network includes: one or more programs including instructions for: receiving a first set of data associated with a first set of communication links, the first set of communication links configured to establish connection between devices; receiving a second set of data associated with a second set of communication links; receiving a determination of whether one or more communication links of the first set satisfy a pre-determined quality level; receiving a determination of whether one or more communication links of the second set satisfy the pre-determined quality level; receiving a selection from the one or more communication links of the second set that have been determined to satisfy the pre-determined quality level; and connecting the devices via the selected one or more communication links if one or more communication links of the first set is determined to not satisfy the pre-determined quality level. |
| FILED | Monday, August 17, 2020 |
| APPL NO | 16/995327 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/5025 (20130101) H04L 43/087 (20130101) H04L 43/0811 (20130101) H04L 47/70 (20130101) Original (OR) Class Wireless Communication Networks H04W 76/10 (20180201) H04W 88/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220053250 | Proietti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Roberto Proietti (Davis, California); Sung-Joo Ben Yoo (Davis, California) |
| ABSTRACT | The disclosed system implements a bandwidth-reconfigurable optical interconnect, which couples optical signals between N interconnect inputs and N interconnect outputs. The system includes an arrayed waveguide grating router (AWGR), which provides cyclic, single-wavelength, all-to-all routing between N AWGR inputs and N AWGR outputs. The system also includes a wavelength-insensitive switch, which provides all-wavelength, all-to-all connectivity between N wavelength-insensitive inputs and N wavelength-insensitive outputs. The system additionally includes a wavelength-selective input switch, which selectively directs up to L wavelengths from each of the N interconnect inputs into a corresponding input of the wavelength-insensitive switch, wherein unselected wavelengths from each of the N interconnect inputs pass into a corresponding AWGR input. Finally, the system includes a wavelength-selective output switch, which selectively directs up to L wavelengths from each of the N wavelength-insensitive outputs into a corresponding interconnect output, wherein each of the N AWGR outputs pass into a corresponding interconnect output. |
| FILED | Wednesday, September 25, 2019 |
| APPL NO | 16/582902 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/2935 (20130101) G02B 6/12019 (20130101) Selecting H04Q 11/0005 (20130101) Original (OR) Class H04Q 2011/0016 (20130101) H04Q 2011/0032 (20130101) H04Q 2011/0039 (20130101) H04Q 2011/0058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220047169 | SMITH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Barbara S. SMITH (Tempe, Arizona); Christopher MIRANDA (Mesa, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Barbara S. SMITH (Tempe, Arizona); Christopher MIRANDA (Mesa, Arizona) |
| ABSTRACT | A system for automated navigation to a target neuron is disclosed. The system comprises a recording electrode including a pipette with a hollow glass tip and a headstage for detecting electrical resistance measurements at the glass tip. The system further comprises an actuator, a light source configured to emit light from the glass tip, an ultrasound transducer for detecting photoacoustic signals in response to the light, a light sensor for detecting optical signals in response to the light, and a processor. The processor iteratively receives the photoacoustic and optical feedback and moves the glass tip via the actuator based on a calculated distance of the target neuron. When the distance at or below a predetermined threshold, the processor maintains the position of the hollow glass tip with respect to the target neuron. Upon successful navigation, the recording electrode may be used to perform single-unit neural recording of the target neuron. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401640 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0042 (20130101) A61B 5/0095 (20130101) Original (OR) Class A61B 2576/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047334 | Meinhold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Waiman Meinhold (Atlanta, Georgia); Ai-Ping Hu (Atlanta, Georgia); John N. Oshinski (Atlanta, Georgia); Jun Ueda (Atlanta, Georgia); Daniel E. Martinez (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides an MRI-compatible robot comprising one or more fiducial markers, a first planar stage comprising a first joint configured to receive a surgical tool and a first mechanism configured to move the surgical tool, a second planar stage comprising a second joint configured to receive the surgical tool and a second mechanism configured to move the surgical tool, and wherein the second planar stage is generally parallel with the first planar stage. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404619 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/20 (20160201) Original (OR) Class A61B 34/30 (20160201) A61B 2034/2051 (20160201) A61B 2090/3954 (20160201) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/427 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/1694 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/287 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047397 | Howell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brigham Young University (BYU) (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Larry L. Howell (Orem, Utah); Collin Ynchausti (Provo, Utah); Anton E. Bowden (Lindon, Utah); Nathan Brown (Orem, Utah) |
| ABSTRACT | Deployable Euler Spiral Connectors (DESCs) are introduced as compliant deployable flexures that can span gaps between segments in a mechanism and then lay flat when under strain in a stowed position. This paper presents models of Euler spiral beams combined in series and parallel that can be used to design compact compliant mechanisms. Constraints on the flexure parameters of DESCs are also presented. Analytic models developed for the force-deflection behavior and stress were compared to finite element analysis and experimental data. A spinal implant and a linear ratcheting system are presented as illustrative applications of DESCs. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/445017 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/442 (20130101) Original (OR) Class A61F 2/468 (20130101) A61F 2/4455 (20130101) A61F 2/30942 (20130101) A61F 2002/30522 (20130101) A61F 2002/30943 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047444 | Walsh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Conor J. Walsh (Cambridge, Massachusetts); Ciaran O'Neill (Cambridge, Massachusetts); Nathan Phipps (Somerville, Massachusetts) |
| ABSTRACT | A textile actuator and harness system can include a harness configured to be worn with a portion extending across a wearer's joint. The harness comprises a substantially inextensible section and at least two mounting locations spaced for positioning across the joint, with at least one located along the substantially inextensible section of the harness. A textile envelope defines a chamber and is made fluid-impermeable by (a) a fluid-impermeable bladder contained in the textile envelope and/or (b) a fluid-impermeable structure incorporated into the textile envelope. The textile envelope is secured to the harness at each mounting location, and the textile envelope has a pre-determined geometry configured to produce assistance to the joint due to inflation of the textile envelope during a relative increase in pressure inside the chamber. |
| FILED | Wednesday, December 04, 2019 |
| APPL NO | 17/298728 |
| CURRENT CPC | Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0281 (20130101) A61H 3/00 (20130101) Original (OR) Class A61H 2201/1238 (20130101) A61H 2201/1409 (20130101) A61H 2201/1638 (20130101) A61H 2201/1652 (20130101) A61H 2201/1659 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 9/0006 (20130101) B25J 9/14 (20130101) Systems Acting by Means of Fluids in General; Fluid-pressure Actuators, e.g Servomotors; Details of Fluid-pressure Systems, Not Otherwise Provided for F15B 15/02 (20130101) F15B 15/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047719 | Scott et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan Alexander Scott (Evanston, Illinois); Trevor Stack (Evanston, Illinois) |
| ABSTRACT | Provided herein are multi-nanoparticle formulations. Also provided herein are methods for enhancing circulation time and/or cell-targeting efficacy of an effector nanoparticle by administering an endocytosis inhibitory nanoparticle and an effector nanoparticle. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/445285 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 47/6907 (20170801) A61K 47/6935 (20170801) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048861 | Odom et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Odom (East Lansing, Michigan); Jetze J. Tepe (East Lansing, Michigan); Theresa A. Lansdell (East Lansing, Michigan) |
| ABSTRACT | Described herein are quinoline compounds useful for, among other things, inhibition of the proteasome and for treatment of cancer and inflammation. |
| FILED | Thursday, February 04, 2021 |
| APPL NO | 17/167271 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/47 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 215/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048866 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chao Zhang (Los Angeles, California); Feng Ni (Los Angeles, California); Arunika Ekanayake (Los Angeles, California); Biancha Espinosa (Los Angeles, California) |
| ABSTRACT | The invention provides a series of GMPS enzyme inhibitors. The invention includes potent GMPS inhibitors that specifically and covalently bind to GMPS, exhibit broad anti-cancer activity, block the infection efficiency of viruses, and have the potentials to suppress undesired immune responses. These novel inhibitors of GMPS, and their derivatives, have tremendous potentials to be used as therapeutic agents for the treatment of cancers, viral infection and immune disorders. |
| FILED | Friday, July 12, 2019 |
| APPL NO | 17/274736 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/517 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 235/56 (20130101) C07C 237/42 (20130101) Heterocyclic Compounds C07D 239/94 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048911 | Shtein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Max Shtein (Ann Arbor, Michigan); Siddharth Borsadia (Ann Arbor, Michigan); Eugene Shteyn (Ann Arbor, Michigan) |
| ABSTRACT | Disclosed herein is a method and apparatus for synthesizing co-crystals from the vapor phase without the need for liquid solvent. Also disclosed herein are co-crystals formed from the vapor phase, substrates coated with said co-crystals, pharmaceutical compositions thereof and apparatuses for producing said co-crystals. |
| FILED | Wednesday, December 11, 2019 |
| APPL NO | 17/312966 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/08 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/13 (20130101) Acyclic or Carbocyclic Compounds C07C 51/43 (20130101) Heterocyclic Compounds C07D 473/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050031 | Anand et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robbyn K. Anand (Ames, Iowa); Beatrise Berzina (Ames, Iowa) |
| ABSTRACT | High-throughput microfluidic devices comprising one or more fluidic microchannels each with at least one flow-through 3D structure comprising a 3D electrode, or alternatively a 3D permselective structure, and optional secondary bead bed(s) are disclosed. Such devices can be used for counter-flow focusing of charged species via ion concentration polarization and in situ quantification of electrokinetically enriched charged species from an ionically conductive solution by both optical and electrical detection. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/445059 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/1603 (20140204) A61M 1/1656 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/40 (20130101) Original (OR) Class G01N 1/2202 (20130101) G01N 2001/4038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050043 | Ozdemir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sahin Kaya Ozdemir (St. Louis, Missouri); Lan Yang (St. Louis, Missouri); Bo Peng (St. Louis, Missouri); Faraz Monifi (San Diego, California) |
| ABSTRACT | An a system and method for chaos transfer between multiple detuned signals in a resonator mediated by chaotic mechanical oscillation induced stochastic resonance where at least one signal is strong and where at least one signal is weak and where the strong and weak signal follow the same route, from periodic oscillations to quasi-periodic and finally to chaotic oscillations, as the strong signal power is increased. |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/446525 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1434 (20130101) Original (OR) Class G01N 21/7746 (20130101) G01N 2021/655 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050299 | Hua et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona); AUGMENTED VISION, INC (TUCSON, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hong Hua (Tucson, Arizona); Chunyu Gao (Tucson, Arizona) |
| ABSTRACT | Eye-tracked head-mounted displays are provide which, in one aspect, may utilize the same optics for eyetracking and image viewing, with a selected portion of the optics used for an eyetracking optical path and a selected portion of the display optics used for an image viewing optical path. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514335 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) G02B 17/086 (20130101) G02B 17/0896 (20130101) G02B 27/017 (20130101) G02B 27/0093 (20130101) G02B 27/0172 (20130101) Original (OR) Class G02B 2027/011 (20130101) G02B 2027/0138 (20130101) G02B 2027/0187 (20130101) Electric Digital Data Processing G06F 3/013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050686 | Gu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (EVANSTON, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jie Gu (Evanston, Illinois); Russell E. Joseph (Evanston, Illinois) |
| ABSTRACT | Systems and/or methods can include techniques to exploit dynamic timing slack on the chip. By using a special clock generator, the clock period can be shrunk as needed at every cycle. The clock period is determined during operation by checking “critical path messengers” to indicate how much dynamic timing slack exists. Elastic pipeline timing can also be introduced to redistribute timing among pipeline stages to bring further benefits. |
| FILED | Wednesday, December 18, 2019 |
| APPL NO | 17/415494 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/08 (20130101) G06F 9/3869 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220051437 | OSTADABBAS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah OSTADABBAS (Watertown, Massachusetts); Shuangjun LIU (Boston, Massachusetts); Xiaofei HUANG (Lynnfield, Massachusetts); Nihang FU (Malden, Massachusetts) |
| ABSTRACT | Methods and systems for providing a dataset of human in-bed poses include simultaneously gathered images of in-bed poses of humans from imaging modalities including red-green-blue (RGB) and one or more of long wavelength infrared (LWIR), depth imaging, and pressure mapping. The images are obtained under a lighting condition and a cover condition. The dataset can be used to train a model of estimating human in-bed poses and for methods of estimating human in-bed poses. Methods and systems of estimating three-dimensional human poses from two-dimensional input images are provided. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/403933 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/50 (20170101) G06T 7/75 (20170101) Original (OR) Class G06T 2207/10024 (20130101) G06T 2207/10028 (20130101) G06T 2207/10048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220051798 | Doryab et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Afsaneh Doryab (Charlottesville, Virginia); Runze Yan (Charlottesville, Virginia); Xinwen Liu (Charlottesville, Virginia) |
| ABSTRACT | A technique for providing biobehavioral rhythm models that generate a series of characteristic features which are further used for measuring stability in biobehavioral rhythms and to predict different outcomes such as health status through a machine learning component. A computational framework is provided for modeling biobehavioral rhythms from mobile and wearable data streams that rigorously processes sensor streams, detects periodicity in data, models rhythms from that data and uses the cyclic model parameters to predict an outcome. The framework can reliably discover various periods of different length in data, extract cyclic biobehavioral characteristics through exhaustive modeling of rhythms for each sensor feature; and provide the ability to use different combination of sensors and data features to predict an outcome. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 17/398097 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4857 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/483 (20130101) Electric Digital Data Processing G06F 30/27 (20200101) G06F 2111/10 (20200101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101) G16H 50/20 (20180101) Original (OR) Class G16H 50/30 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052323 | Mangolini et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lorenzo Mangolini (Yorba Linda, California); Giorgio Nava (Riverside, California); Joseph Schwan (Riverside, California) |
| ABSTRACT | Discussed herein are methods for making an anode material comprising silicon nanoparticles and a graphite carbon coating thereon. The method can include providing silicon nanoparticles, applying an amorphous carbon coating thereon to create an amorphous carbon shell on the silicon nanoparticles at a first temperature, and converting the amorphous carbon shell to a graphite carbon shell at a second temperature higher than the first temperature. The method can optionally include producing silicon nanoparticles by providing an argon-silane mixture, exposing the argon-silane mixture to a non-thermal plasma to convert the silane mixture to amorphous clusters, and passing the amorphous clusters through a furnace at a first temperature so as to agglomerate them to silicon nanoparticles. |
| FILED | Wednesday, February 26, 2020 |
| APPL NO | 17/434164 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 33/02 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/26 (20130101) C23C 16/56 (20130101) C23C 16/4417 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/366 (20130101) Original (OR) Class H01M 4/386 (20130101) H01M 4/625 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052431 | Friedman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Amherst College (Amherst, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan R. Friedman (Amherst, Massachusetts) |
| ABSTRACT | Improved loop-gap resonators applicable to Electron-Spin Resonance spectroscopy and to quantum computing employ interdigitated capacitor structures to dramatically increase the capacitance of the resonator, along with corresponding decreases in loop size to enable measurements of small-volume samples or individual quantum bits (qubits). The interdigitated-capacitor structures are designed to minimize parasitic inductance. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514188 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/60 (20130101) G01R 33/343 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/06 (20130101) Original (OR) Class H01P 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052898 | Walk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California); Technische Universität Berlin (Berlin, Germany) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California); Technische Universität Berlin (Berlin, Germany) |
| INVENTOR(S) | Philipp Walk (Pasadena, California); Babak Hassibi (San Marino, California); Peter Jung (Berlin, Germany) |
| ABSTRACT | Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros. |
| FILED | Monday, March 15, 2021 |
| APPL NO | 17/202221 |
| CURRENT CPC | Multiplex Communication H04J 11/00 (20130101) H04J 2011/0096 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/0204 (20130101) H04L 27/2627 (20130101) Original (OR) Class H04L 27/2639 (20130101) H04L 27/2649 (20130101) H04L 27/2663 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220053250 | Proietti et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Roberto Proietti (Davis, California); Sung-Joo Ben Yoo (Davis, California) |
| ABSTRACT | The disclosed system implements a bandwidth-reconfigurable optical interconnect, which couples optical signals between N interconnect inputs and N interconnect outputs. The system includes an arrayed waveguide grating router (AWGR), which provides cyclic, single-wavelength, all-to-all routing between N AWGR inputs and N AWGR outputs. The system also includes a wavelength-insensitive switch, which provides all-wavelength, all-to-all connectivity between N wavelength-insensitive inputs and N wavelength-insensitive outputs. The system additionally includes a wavelength-selective input switch, which selectively directs up to L wavelengths from each of the N interconnect inputs into a corresponding input of the wavelength-insensitive switch, wherein unselected wavelengths from each of the N interconnect inputs pass into a corresponding AWGR input. Finally, the system includes a wavelength-selective output switch, which selectively directs up to L wavelengths from each of the N wavelength-insensitive outputs into a corresponding interconnect output, wherein each of the N AWGR outputs pass into a corresponding interconnect output. |
| FILED | Wednesday, September 25, 2019 |
| APPL NO | 16/582902 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/2935 (20130101) G02B 6/12019 (20130101) Selecting H04Q 11/0005 (20130101) Original (OR) Class H04Q 2011/0016 (20130101) H04Q 2011/0032 (20130101) H04Q 2011/0039 (20130101) H04Q 2011/0058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220046929 | Craven et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Noble Research Institute, LLC (ARDMORE, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelly Craven (Ardmore, Oklahoma); Prasun Ray (Ardmore, Oklahoma) |
| ABSTRACT | The present disclosure provides a novel endophyte, Serendipita vermifera ssp. bescii (“S. bescii”), uses thereof and methods incorporating the use thereof for enhancement of plant performance, particularly the use of S. bescii with phosphite as a phosphorous source. The present disclosure also provides methods for detecting the presence of and identifying S. bescii. |
| FILED | Friday, June 05, 2020 |
| APPL NO | 16/894573 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/08 (20130101) A01N 63/30 (20200101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220047730 | Tang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Yng Tang (Davis, California); Julie L. Sutcliffe (Davis, California) |
| ABSTRACT | The present invention provides peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates comprise a moiety such as a PEG moiety, an imaging agent, or a therapeutic agent. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue. Compositions and kits containing the peptide conjugates of the present invention are also provided herein. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504072 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) A61K 38/10 (20130101) A61K 38/1777 (20130101) A61K 47/60 (20170801) A61K 47/62 (20170801) A61K 51/088 (20130101) Original (OR) Class Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048007 | O'Malley |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kyle O'Malley (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyle O'Malley (Albuquerque, New Mexico) |
| ABSTRACT | Oxygen carriers for chemical looping and scalable methods of preparation thereof. Wet impregnation of active metal precursors into porous substrates, together with selective adsorption of the precursors on the pore surfaces, enables transition metal oxides derived from the precursors to disperse throughout the substrate, even at the nanoscale, without increased sintering or agglomeration. The porous substrate can be an oxide, for example SiO2. The oxygen carriers can comprise relatively large oxide loadings of over about 20 wt % and exhibit high reactivity over many regeneration cycles with substantially no loss in oxygen transport capacity or decrease in kinetics. The use of multiple transition metals, for example NiO in addition to CuO, can greatly enhance chemical looping performance. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/402342 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/103 (20130101) B01J 20/223 (20130101) B01J 20/0225 (20130101) B01J 20/0237 (20130101) Original (OR) Class B01J 20/28069 (20130101) B01J 2220/42 (20130101) B01J 2220/46 (20130101) Methods or apparatus for combustion using fluid fuel or Solid Fuel Suspended In Air F23C 99/00 (20130101) F23C 2900/99008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048138 | Kustas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Lehigh University (Bethlehem, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Kustas (Albuquerque, New Mexico); Donald F. Susan (Albuquerque, New Mexico); Tomas Farley Babuska (Tallahassee, Florida); Kyle Johnson (Starkville, Mississippi); Brandon Krick (Tallahassee, Florida); Trevor Verdonik (Schuylkill Haven, Pennsylvania) |
| ABSTRACT | The present invention provides an additive manufacturing (AM) processing and design approach using removable “heat sink” artifacts to tailor the mechanical properties of traditionally low strength and low ductility alloys. As an example, the design approach was demonstrated with the Fe-50 at. % Co alloy, as a model material of interest for electromagnetic applications. AM-processed components exhibited unprecedented performance, with a 300% increase in strength and an order-of-magnitude improvement in ductility relative to conventional wrought material. The method enables the design and processing of high-performance, next-generation components and alloys. |
| FILED | Wednesday, August 12, 2020 |
| APPL NO | 16/991203 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/082 (20151001) B23K 26/342 (20151001) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Alloys C22C 38/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048243 | Gould et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin J. Gould (Chicago, Illinois); Aaron C. Greco (Chicago, Illinois); Sarah J. Wolff (Chicago, Illinois) |
| ABSTRACT | A method for performing sub-surface porosity detection in an additively manufactured part. The method includes providing, by a laser radiation source, a first radiation to a region of a powder bed along a beam of the first radiation, the region of the powder bed being part of a corresponding region of an additively manufactured part. Infrared imaging of the region of the powder bed is performed while the first radiation is being provided to the powder bed. A processor generates data sets indicative of the temperature of the region of the powder bed; and the processor further detects, from the data sets, a defect signature indicative of the formation and/or presence of a sub-surface defect in the region of the additively manufactured part. |
| FILED | Thursday, August 13, 2020 |
| APPL NO | 16/992496 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) Original (OR) Class B29C 64/188 (20170801) B29C 64/245 (20170801) B29C 64/268 (20170801) B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048766 | Granovskiy |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SOUTHERN RESEARCH INSTITUTE (Birmingham, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mikhail Granovskiy (Fultondale, Alabama) |
| ABSTRACT | Disclosed herein is a method and a reactor for the conversion of a hydrocarbon gas to syngas. The method and reactor utilizes a oxy-hydrogen flame to partially oxidize hydrocarbon gas to syngas by provide an excess flow of oxygen gas. The oxy-hydrogen flame is generated by a multi-tubular oxy-hydrogen burner. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399462 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 12/00 (20130101) B01J 19/0013 (20130101) B01J 19/242 (20130101) B01J 2219/00157 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/363 (20130101) Original (OR) Class C01B 3/382 (20130101) C01B 2203/0233 (20130101) C01B 2203/0238 (20130101) C01B 2203/0255 (20130101) C01B 2203/0816 (20130101) C01B 2203/0822 (20130101) C01B 2203/1241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220048834 | RUDDY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel RUDDY (Arvada, Colorado); Jesse Evan HENSLEY (Arvada, Colorado); Joshua A. SCHAIDLE (Arvada, Colorado); Connor Patrick NASH (Lakewood, Colorado); Anh The TO (Denver, Colorado) |
| ABSTRACT | The present disclosure relates to a method that includes converting a gas stream that contains hydrogen (H2) and carbon monoxide (CO) to a second mixture that contains a hydrocarbon, for example, a hydrocarbon having between 3 and 15 carbon atoms, where the converting is performed using a first catalyst configured to convert H2 and CO to methanol, a second catalyst configured to convert methanol to dimethyl ether (DME), and a third catalyst configured to convert DME to the hydrocarbon. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401778 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 8/04 (20130101) B01J 21/04 (20130101) B01J 21/08 (20130101) B01J 21/066 (20130101) B01J 23/72 (20130101) B01J 23/80 (20130101) B01J 29/7007 (20130101) B01J 35/0006 (20130101) B01J 2208/025 (20130101) B01J 2208/027 (20130101) Acyclic or Carbocyclic Compounds C07C 1/22 (20130101) Original (OR) Class C07C 29/154 (20130101) C07C 41/09 (20130101) C07C 2521/04 (20130101) C07C 2521/06 (20130101) C07C 2521/08 (20130101) C07C 2523/06 (20130101) C07C 2523/72 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049328 | Saw et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cheng K. Saw (Livermore, California); ByoungWoo William Choi (Livermore, California) |
| ABSTRACT | A product includes a ternary alloy consisting essentially of Sn4Li(4+x)Zn(8−x), where x=0 to <8. A method includes forming a ternary alloy using a mechanical alloying process. The ternary alloy consists essentially of Sn4Li(4+x)Zn(8−x), where x=0 to <8. |
| FILED | Friday, August 14, 2020 |
| APPL NO | 16/994324 |
| CURRENT CPC | Alloys C22C 1/0408 (20130101) C22C 24/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049368 | Tripathy |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prabhat K. Tripathy (Idaho Falls, Idaho) |
| ABSTRACT | A method of forming a metal alloy. The method comprises forming a metal oxide precursor and conducting cathodic polarization of the metal oxide precursor in a molten salt electrolyte to form a metal alloy. In an additional method, a metal oxide precursor is formed. The metal oxide precursor is reduced to a metal in an electrochemical cell that comprises a working electrode, a counter electrode, and an electrolyte. The metal is reacted with a metal of the working electrode to form a metal alloy. In another method, a metal oxide precursor is formed on a base material. The base material is introduced into a molten salt electrolyte of an electrochemical cell and the metal oxide precursor is reduced to a metal in the electrochemical cell. The metal is reacted with the base material to form a metal alloy on the base material. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399648 |
| CURRENT CPC | Production and Refining of Metals; Pretreatment of Raw Materials C22B 1/16 (20130101) C22B 4/06 (20130101) Alloys C22C 27/02 (20130101) Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050697 | Oesch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy S. Oesch (Oak Ridge, Tennessee); Robert A. Bridges (Oak Ridge, Tennessee); Jeffrey A. Nichols (Oak Ridge, Tennessee); Jared M. Smith (Oak Ridge, Tennessee); Kiren E. Verma (Oak Ridge, Tennessee); Brian Weber (Oak Ridge, Tennessee); Oumar Souleymane Diallo (Oak Ridge, Tennessee) |
| ABSTRACT | Whether testing intrusion detection systems, conducting training exercises, or creating data sets to be used by the broader cybersecurity community, realistic user behavior is a desirable component of a cyber-range. Existing methods either rely on network level data or replay recorded user actions to approximate real users in a network. Probabilistic models can be fit to actual user data (sequences of application usage) collected from endpoints. Once trained to the user's behavioral data, these models can generate novel sequences of actions from the same distribution as the training data. These sequences of actions can be fed to emulator software via configuration files, which replicate those behaviors on end devices. The models are platform agnostic and can generate behavior data for any emulation software package. In some embodiments a latent variable is added to faithfully capture and leverage time-of-day trends. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 17/398358 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/455 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052325 | Xiao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Jie Xiao (Richland, Washington); Jun Liu (Richland, Washington); Hongkyung Lee (Richland, Washington); Dianying Liu (Richland, Washington); Chaojiang Niu (Richland, Washington) |
| ABSTRACT | A lithium metal pouch cell having a specific energy ≥300 Wh·kg−1 includes an anode comprising lithium metal and an anode current collector, the anode having an areal capacity N (mAh·cm−2); a cathode comprising a cathode material and a cathode current collector, the cathode having an a real capacity P (mAh·cm−2), wherein a ratio of N/P is within a range of 0.02 to 5; an electrolyte having an electrolyte mass E and comprising a lithium active salt and a solvent, the lithium metal pouch cell having an electrolyte mass to cell capacity (E/C) ratio within a range of 1 to 6 g·Ah−1; a separator positioned between the anode and the cathode; and a packaging material defining a pouch enclosing the anode, cathode, electrolyte, and separator; wherein a protruding tab of the anode current collector and a protruding tab of the cathode current collector are external to the pouch. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512197 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/661 (20130101) H01M 10/0525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052357 | Bae et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chulsung Bae (Cohoes, New York); Ding Tian (Troy, New York) |
| ABSTRACT | Ion exchange membranes materials according to the present disclosure exhibit improved conductivity at low and intermediate relative humidity without sacrificing mechanical strength. Polymers are provided that include a backbone with one or more aryl groups, a halocarbyl group, and a halocarbyl side chain attached to the backbone, wherein the halocarbyl side chain includes a halide separated from the backbone by a hydrocarbyl chain, a hydrocarbyl ring, or combinations thereof. The halide is substituted with a tertiary amine and halide anions are then exchanged with hydroxide anions. The polymers are then contacted with phosphoric acid, which is deprotonated by the hydroxide ions, forming anions which enhance interactions with adjacent quaternary ammonium groups and induce excess phosphoric acid molecules to cluster around those quaternary ammonium groups. The membranes exhibit negligible dopant leaching even at high relative humidity. |
| FILED | Tuesday, November 26, 2019 |
| APPL NO | 17/309401 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2281 (20130101) C08J 5/2293 (20130101) C08J 2300/106 (20130101) C08J 2423/04 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0289 (20130101) Original (OR) Class H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052363 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ESS Tech, Inc. (Wilsonville, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Song (West Linn, Oregon); Evan Doremus (Portland, Oregon) |
| ABSTRACT | Systems and methods for operating a redox flow battery system may include switching the redox flow battery system to an idle mode, wherein the idle mode includes operation of the redox flow battery system outside of a charging mode and outside of a discharge mode; in response to switching to the idle mode, repeatedly cycling operation of an electrolyte pump between an idling threshold flow rate less than a charging threshold flow rate and a deactivation threshold flow rate; and in response to switching to the charging mode, maintaining operation of the electrolyte pump at the charging threshold flow rate greater than the idling threshold flow rate. In this way, a responsiveness of the redox flow battery system to charging and discharging commands can be maintained while in idle, while reducing parasitic pumping losses due to pumping and heating, and reducing shunt current losses. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/453324 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/18 (20130101) H01M 8/043 (20160201) H01M 8/188 (20130101) H01M 8/2455 (20130101) H01M 8/04201 (20130101) H01M 8/04753 (20130101) Original (OR) Class Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220052626 | Xue et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lingxiao Xue (Oak Ridge, Tennessee); Gui-Jia Su (Oak Ridge, Tennessee) |
| ABSTRACT | A control system and method for an inverter that reduces capacitor current through a DC bus capacitor of the inverter. The control system and method may generate switching signals for a plurality of switching circuits in a manner that reduces capacitor current through the DC bus capacitor. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400169 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/5387 (20130101) H02M 7/5395 (20130101) Original (OR) Class Control or Regulation of Electric Motors, Electric Generators or Dynamo-electric Converters; Controlling Transformers, Reactors or Choke Coils H02P 5/74 (20130101) H02P 27/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220049419 | Zhu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Junyong Zhu (Madison, Wisconsin); Roland Gleisner (Jefferson, Wisconsin) |
| ABSTRACT | Methods of fractionating lignocellulosic biomass using maleic acids are provided. Also provided are methods of forming lignin particles, furans, sugars, and/or lignocellulosic micro- and nanofibrils from the liquid and solid fractions produced by fractionation process. The fractionation can be carried out at low temperatures with short reaction times to carboxylate and dissolve lignin with a low degree of condensation. |
| FILED | Tuesday, August 11, 2020 |
| APPL NO | 16/990459 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/02 (20130101) C12P 19/14 (20130101) Production of Cellulose by Removing Non-cellulose Substances From Cellulose-containing Materials; Regeneration of Pulping Liquors; Apparatus Therefor D21C 3/04 (20130101) Original (OR) Class D21C 9/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220049428 | GLENN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); WORLD CENTRIC (Rohnert Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | GREGORY M. GLENN (GRAND JUNCTION, Colorado); XING JIN (ALBANY, California); RANDAL L. SHOGREN (COLUMBIA FALLS, Montana) |
| ABSTRACT | The invention relates to uncoated, fiber/starch composite materials manufactured without the use of fluorochemicals or additional binders that offer superior oil and grease resistance properties. Addition of an internal sizing agent in the preparation of the fiber/starch composite materials results in superior hot water and cold water resistance properties. The fiber/starch composite materials may be used for the manufacture of food service containers. The invention also relates to methods of preparation of the fiber/starch composite materials. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401712 |
| CURRENT CPC | Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 65/38 (20130101) Pulp Compositions; Preparation Thereof Not Covered by Subclasses D21C or D21D; Impregnating or Coating of Paper; Treatment of Finished Paper Not Covered by Class B31 or Subclass D21G; Paper Not Otherwise Provided for D21H 17/17 (20130101) D21H 17/28 (20130101) Original (OR) Class D21H 21/16 (20130101) D21H 23/04 (20130101) Fibreboard; Manufacture of Articles From Cellulosic Fibrous Suspensions or From Papier-mache D21J 3/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220051569 | LARSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ACTA, LLC (Torrance, California) |
| ASSIGNEE(S) | ACTA, LLC (Torrance, California) |
| INVENTOR(S) | Erik LARSON (Torrance, California); Tyler GRAS (Torrance, California); Steven CARBON (Torrance, California) |
| ABSTRACT | Described are techniques for determining measures of risk through a medium fidelity, fast running flight risk analysis system, for evaluating risk of a launch or reentry. The method may include receiving trajectory information associated with a planned flight, wherein the trajectory information comprises a series of trajectory vectors, each trajectory vector comprising time information, position information and velocity information. Identification of consequences of interest, and an extent of a region of interest for potential hazard areas may also be received. The method may include determining an upper bound of expected consequence for each population center based on a number of people in each population center subject to different consequences, determining one or more collective risk metrics for each population center, and a collective risk metric for all population centers. |
| FILED | Wednesday, April 07, 2021 |
| APPL NO | 17/224445 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/242 (20130101) Traffic Control Systems G08G 5/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220051584 | Kirkman |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The MITRE Corporation (McLean, Virginia) |
| ASSIGNEE(S) | The MITRE Corporation (McLean, Virginia) |
| INVENTOR(S) | Robin Kirkman (Centreville, Virginia) |
| ABSTRACT | A method of performing a flight simulation is provided. The method includes retrieving a flight action, mapping the flight action to an instruction, the instruction being configured to bring about a desired state of a flight simulator, identifying a command based on the desired state of the flight simulator and a first state of the flight simulator, and determining if a second state of the flight simulator after executing the command matches the desired state of the flight simulator. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405291 |
| CURRENT CPC | Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 9/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220050279 | Grunwald et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Grunwald (Worcester, Massachusetts); Maximiliaan Huisman (North Brookfield, Massachusetts) |
| ABSTRACT | The invention provides for a system and methods of directly delivering excitation light to a sample by a path that avoids traveling though the objective and dichroic mirror. Certain embodiments of the system may include an excitation light source, and a series of mirrors and lenses to direct the excitation light to a diffuser unit. The diffuser unit may then generate a configurable illumination profile to evenly illuminate a sample. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/274627 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) Original (OR) Class G02B 21/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220050282 | Grunwald et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Grunwald (Worcester, Massachusetts); Maximiliaan Huisman (North Brookfield, Massachusetts); Karina Jouravleva (Worcester, Massachusetts); Carlas Smith (Delft, Netherlands); Phillip D. Zamore (Northborough, Massachusetts) |
| ABSTRACT | The invention is directed to a heated stage assembly that can achieve high temperatures (i.e., 40 degrees Celsius and higher and more specifically, 55 degrees Celsius and higher) for use in microscopy including fluorescence microscopy. The microscope stage heater assembly includes a mounting adapter element, a sample holder element mounted within the mounting adapter element, one or more heating elements attached to the sample holder element, and an optical window holder element disposed on a surface of the sample holder element that encloses an optical window element. The optical window element may be in contact with a microscope sample such that the optical window element is heated by the sample holder element to uniformly distribute heat to the specimen. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/274625 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/16 (20130101) G02B 21/26 (20130101) G02B 21/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. Agency for International Development (USAID)
| US 20220046869 | SOKOL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julia SOKOL (Cambridge, Massachusetts); Jaya NARAIN (Santa Clara, California); Amos Greene WINTER, V (Somerville, Massachusetts); Jeffrey COSTELLO (Brighton, Massachusetts); Dheekshita KUMAR (East Walpole, Massachusetts); Tristan J. MCLAURIN (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for modeling ways to best design pressure-controlled drip irrigation emitters are provided. The systems and methods are designed to help reduce activation pressure while maintaining a substantially constant, desirable flow rate in an irrigation system. Various parameters that impact the activation pressure and the flow rate can be adjusted to assist in finding optimal designs. The parameters can at least include one or more of resistances in a flow path, resistances in a membrane cavity, a membrane, or placement of a membrane with respect to a membrane cavity. Optimal designs for such emitters based on the discloses systems and methods are provided, including at least one exemplary embodiment in which a length of a flow path is substantially reduced as compared to known emitters. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/402209 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 25/023 (20130101) Original (OR) Class A01G 2025/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220046870 | SOKOL et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julia SOKOL (Cambridge, Massachusetts); Jaya NARAIN (Santa Clara, California); Amos Greene WINTER, V (Somerville, Massachusetts); Jeffrey COSTELLO (Brighton, Massachusetts); Dheekshita KUMAR (East Walpole, Massachusetts); Tristan J. MCLAURIN (Cambridge, Massachusetts) |
| ABSTRACT | Drip irrigation emitters having low activation pressures, desirable flow rates, and are configured to clog less than existing emitters are provided. The disclosed emitters include membrane cavities that are devoid of a channel and a land to help advance fluid through the cavity, to an outlet, and to an outside environment. Instead, the membrane cavities have various shapes and configurations that, in conjunction with a depressed membrane, help to drive fluid out of the membrane cavity and to an outside environment. The shapes of the membrane cavities include a sinusoidal configuration, a cylindrical shape configuration, and a flat bottom configuration. Various features of such emitters, and methods of using the same, are also provided. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/402234 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 25/023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220049905 | Pounds et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ThermAvant Technologies, LLC (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel A. Pounds (Columbia, Missouri); Joe Boswell (San Francisco, California); Brian Adams (Columbia, Missouri); Benjamin Alexander (Columbia, Missouri); Joshua Schorp (Columbia, Missouri) |
| ABSTRACT | A monolithic oscillating heat pipe (OHP) device comprising a monolithic body and an oscillating heat pipe (OHP) circuit integrally formed within the body. The OHP circuit is structured and operable to isothermally spread throughout the body heat from a heat source disposed on a heat source portion of the body and in thermally conductive contact with a portion of the OHP circuit. The monolithic OHP device further comprising a pumped fluid (PF) circuit integrally formed within the body and in thermally conductive contact with at least portion of the OHP circuit internally within the body. The PF circuit is structured and operable to remove heat from the portion of the OHP circuit in which the PF circuit is in thermally conductive contact with. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404772 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/04 (20130101) F28D 15/0233 (20130101) F28D 15/0275 (20130101) Original (OR) Class Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 13/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220053250 | Proietti et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Roberto Proietti (Davis, California); Sung-Joo Ben Yoo (Davis, California) |
| ABSTRACT | The disclosed system implements a bandwidth-reconfigurable optical interconnect, which couples optical signals between N interconnect inputs and N interconnect outputs. The system includes an arrayed waveguide grating router (AWGR), which provides cyclic, single-wavelength, all-to-all routing between N AWGR inputs and N AWGR outputs. The system also includes a wavelength-insensitive switch, which provides all-wavelength, all-to-all connectivity between N wavelength-insensitive inputs and N wavelength-insensitive outputs. The system additionally includes a wavelength-selective input switch, which selectively directs up to L wavelengths from each of the N interconnect inputs into a corresponding input of the wavelength-insensitive switch, wherein unselected wavelengths from each of the N interconnect inputs pass into a corresponding AWGR input. Finally, the system includes a wavelength-selective output switch, which selectively directs up to L wavelengths from each of the N wavelength-insensitive outputs into a corresponding interconnect output, wherein each of the N AWGR outputs pass into a corresponding interconnect output. |
| FILED | Wednesday, September 25, 2019 |
| APPL NO | 16/582902 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/2935 (20130101) G02B 6/12019 (20130101) Selecting H04Q 11/0005 (20130101) Original (OR) Class H04Q 2011/0016 (20130101) H04Q 2011/0032 (20130101) H04Q 2011/0039 (20130101) H04Q 2011/0058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Nuclear Regulatory Commission (NRC)
| US 20220047704 | GARNER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); Nanovis, LLC (Columbia City, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Allen Lawrence GARNER (West Lafayette, Indiana); Ram Anand VADLAMANI (West Lafayette, Indiana); David Alan DETWILER (Columbia City, Indiana) |
| ABSTRACT | Provided is a method of reducing a number of viable microbes, including contacting microbes with an antibiotic compound and applying pulses of electricity having a duration of between about 50 nanoseconds and about 900 nanoseconds. The pulses of electricity may have an intensity between about 20 kV/cm and about 40 kV/cm. The pulses of electricity may be applied at a frequency of between about 0.1 Hz and about 10 Hz. The microbes may be a gram-negative or a gram-positive strain of bacteria and the antibiotic may be applied at a concentration for a duration, wherein applying the antibiotic to the strain at the concentration for the duration does not reduce a viable number of bacteria of the strain as much, or at all, when the pulses of electricity are not also applied. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461143 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/341 (20130101) A61K 31/496 (20130101) A61K 31/575 (20130101) A61K 31/702 (20130101) A61K 31/5377 (20130101) A61K 31/7048 (20130101) A61K 38/14 (20130101) A61K 41/0023 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220052357 | Bae et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rensselaer Polytechnic Institute (Troy, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chulsung Bae (Cohoes, New York); Ding Tian (Troy, New York) |
| ABSTRACT | Ion exchange membranes materials according to the present disclosure exhibit improved conductivity at low and intermediate relative humidity without sacrificing mechanical strength. Polymers are provided that include a backbone with one or more aryl groups, a halocarbyl group, and a halocarbyl side chain attached to the backbone, wherein the halocarbyl side chain includes a halide separated from the backbone by a hydrocarbyl chain, a hydrocarbyl ring, or combinations thereof. The halide is substituted with a tertiary amine and halide anions are then exchanged with hydroxide anions. The polymers are then contacted with phosphoric acid, which is deprotonated by the hydroxide ions, forming anions which enhance interactions with adjacent quaternary ammonium groups and induce excess phosphoric acid molecules to cluster around those quaternary ammonium groups. The membranes exhibit negligible dopant leaching even at high relative humidity. |
| FILED | Tuesday, November 26, 2019 |
| APPL NO | 17/309401 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2281 (20130101) C08J 5/2293 (20130101) C08J 2300/106 (20130101) C08J 2423/04 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/0289 (20130101) Original (OR) Class H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220052457 | ARUMUGAM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Darmindra D. ARUMUGAM (Pasadena, California); Jack D. BUSH (Pasadena, California) |
| ABSTRACT | An electrically small electroquasistatic antenna having a structure that reduces radiated magnetic fields and maintains suitable radiated electrical fields. The electroquasistatic antenna is a dipole antenna that is electrically short, which presents as a capacitor for use as an electroquasistatic antenna, with one or multiple counterposed inductive elements to resonate the antenna and provide high efficiency while simultaneously canceling the external magnetic fields. The electroquasistatic antenna may be configured for operation as an electroquasistatic exciter or electroquasistatic detector. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511464 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/362 (20130101) H01Q 11/08 (20130101) Original (OR) Class H01Q 19/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, February 17, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2021/details-patents-20210427.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page