FedInvent™ Patent Applications

Application Details for Thursday, March 03, 2022 

This page was updated on Monday, March 07, 2022 at 10:38 AM GMT

Department of Health and Human Services (HHS) 

US 20220061311 Johnson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) The Regents of the University of Colorado, a body (Denver, Colorado)
ASSIGNEE(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado)
INVENTOR(S) Thomas E. Johnson (Louisville, Colorado);  James R. Cypser (Westminster, Colorado);  Wallace S. Chick (Centennial, Colorado);  Garrett J. Schumacher (Sterling, Colorado)
ABSTRACT Compositions and methods for reducing the toxic effects of cryopreservation in living materials undergoing standard cryopreservation procedures. In embodiments of the present invention such methods including blocking or reducing the function of the Gm14005, Nrg2/Pura, Fgd2/Pim1, Opa1/Hes1, Myh9, and Hsbp1/Ywhag genes, their gene products, or their downstream effectors. In embodiments, cells, tissues, organs, or organisms are treated with Afatinib, Staurosporine, UCN-01, Quercetagetin, LY294002, Quercetin, Adenosine monophosphate, Blebbistatin, or Agalloside prior to, during, or after the cryopreservation process to reduce cryopreservation toxicity.
FILED Monday, November 04, 2019
APPL NO 17/291204
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 1/0221 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220061331 Dimopoulos et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) George Dimopoulos (Baltimore, Maryland);  Sarah M. Short (Baltimore, Maryland);  Jose L. Ramirez (Rockville, Maryland)
ABSTRACT The present invention relates to the fields of malaria and dengue virus. More specifically, the present invention provides compositions and methods useful for the treatment and prevention of malaria and dengue virus. In particular embodiments, a composition comprises mosquito nectar feed and Chromobacterium sp_Panamam (Csp_P).
FILED Thursday, July 29, 2021
APPL NO 17/388392
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 63/20 (20200101) Original (OR) Class

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7004 (20130101)
A61K 35/74 (20130101)
A61K 2300/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
C12N 1/205 (20210501)

Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms
C12R 2001/01 (20210501)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220061725 KLIN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) Children's Healthcare of Atlanta, Inc. (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Ami KLIN (Atlanta, Georgia);  Warren Jones (Decatur, Georgia);  Sarah Shultz (Atlanta, Georgia)
ABSTRACT The present systems and methods provide a mechanism to assess viewer behavior, features of stimuli, and the interaction between viewer behavior and stimuli. The systems and methods described herein for quantifying blink response and blink inhibition provide moment-by-moments measurements of viewer engagement by measuring what is or is not engaging enough to warrant viewers' inhibition of blinking. The present disclosure describes measures of visual scanning, eye movements, blink data, and blink timing data to derive a measure of how engaged a person is with what he or she is looking at. Blink-related data as a measure of viewer engagement provides a mechanism for determining the most engaging spatial and temporal aspects of a stimulus.
FILED Monday, March 22, 2021
APPL NO 17/208177
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 3/0025 (20130101)
A61B 3/0041 (20130101)
A61B 3/112 (20130101)
A61B 3/113 (20130101)
A61B 5/163 (20170801)
A61B 5/165 (20130101) Original (OR) Class
A61B 5/167 (20130101)
A61B 5/168 (20130101)
A61B 5/1103 (20130101)
A61B 5/4088 (20130101)
A61B 5/7275 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220061807 Yen
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
ASSIGNEE(S)
INVENTOR(S) Jesse Tong-Pin Yen (La Crescenta, California)
ABSTRACT An ultrasound system is disclosed that utilizes an arbitrary waveform generator, memory, and an ultrasound transducer. A plurality of excitation waveforms are stored in the memory and may be output from the arbitrary waveform generator to an ultrasound transducer. At least one first excitation waveform is stored in the memory and includes an excitation portion with no damping portion (e.g., for one ultrasound procedure; such that an output from the ultrasound transducer is of a first bandwidth). At least one second excitation waveform is stored in the memory and includes an excitation portion and a damping portion (e.g., for another ultrasound procedure; such that an output from the ultrasound transducer is of a second bandwidth that is larger than the first bandwidth).
FILED Thursday, August 26, 2021
APPL NO 17/412696
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 8/463 (20130101)
A61B 8/469 (20130101)
A61B 8/4483 (20130101) Original (OR) Class

Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General
B06B 1/0644 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220061831 Byju et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) The Texas A and M University System (College Station, Texas);  Baylor College of Medicine (Houston, Texas);  Fannin Partners, LLC (Houston, Texas)
ASSIGNEE(S) The Texas A and M University System (College Station, Texas);  Baylor College of Medicine (Houston, Texas);  Fannin Partners, LLC (Houston, Texas)
INVENTOR(S) Achu Geetha Byju (College Station, Texas);  Balakrishna Haridas (College Station, Texas);  Jimmy Espinoza (Houston, Texas);  Michael J. Belfort (Houston, Texas);  Michael J. Heffernan (Katy, Texas)
ABSTRACT An approximating anchor device, corresponding kits, and methods for implementing the device are described herein. In one embodiment, the approximating anchor device includes a first cylindrical fastener defining a first set of cross lumens, each of the first set of cross lumens extending substantially perpendicular to a central axis of the first cylindrical fastener, a second cylindrical fastener defining a second set of cross lumens, each of the second set of cross lumens extending substantially perpendicular to a central axis of the second cylindrical fastener, and a string running through the first set of cross lumens of the first cylindrical fastener and the second set of cross lumens of the second cylindrical fastener. Tightening of the string will draw the first cylindrical fastener and the second cylindrical fastener towards each other.
FILED Friday, January 03, 2020
APPL NO 17/420212
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 1/3132 (20130101)
A61B 17/0401 (20130101) Original (OR) Class
A61B 2017/4216 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220061929 Tao et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Yuankai Tao (Nashville, Tennessee);  Mohamed T. El-Haddad (Nashville, Tennessee)
ABSTRACT Systems and methods for image-based guidance using automated instrument tracking. An en face image frame, generated from en face image data captured by a first imaging system (e.g., an SER imaging system), is analyzed to determine a location of an instrument in the first imaging plane. A control signal is then generated for the movement stage to control the scanning movement of a depth-based imaging system (e.g., an OCT imaging system) based on the determined location of the instrument. In some implementations, a trained neural-network is used to determine the location of the instrument based on the en face image frame and, in some implementations, the control signal adjusts the speed of the scanning movement to capture image data at a higher density7 at areas corresponding to the determined location of the instrument.
FILED Friday, January 10, 2020
APPL NO 17/421558
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 34/20 (20160201) Original (OR) Class
A61B 2034/2055 (20160201)
A61B 2034/2065 (20160201)

Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 9/02091 (20130101)

Optical Elements, Systems, or Apparatus
G02B 26/101 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)

Image Data Processing or Generation, in General
G06T 3/40 (20130101)
G06T 7/70 (20170101)
G06T 2207/10028 (20130101)
G06T 2207/10101 (20130101)
G06T 2207/20084 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 30/40 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062180 Slocum et al.
FUNDED BY
Department of Health and Human Services (HHS)
Food and Drug Administration (FDA)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Alexander H. Slocum (Bow, New Hampshire);  Bernhardt Levy Trout (Lexington, Massachusetts)
ABSTRACT System and methods related to lyophilization of pharmaceutical products are disclosed. In some embodiments, vials of product are moved through a system using one or more movers which are electromagnetically levitated and moved through the system without making mechanical contact with each other or the system. Load lock chambers may allow a mover to enter from one process region's environment and then be brought to an environment condition of the next process region to allow materials to be passed through conditioning, nucleation, and/or vacuum drying regions prior to finally exit the system to an unloading zone. The movers may then be cleaned or reloaded with vials to begin the process again with a new load of vials.
FILED Friday, June 25, 2021
APPL NO 17/359394
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/19 (20130101) Original (OR) Class

Drying Solid Materials or Objects by Removing Liquid Therefrom
F26B 5/06 (20130101)

Electric Machines Not Otherwise Provided for
H02N 15/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062212 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) University of Cincinnati (Cincinnati, Ohio)
ASSIGNEE(S)
INVENTOR(S) Jianjun Chen (Cincinnati, Ohio);  Rui Su (Cincinnati, Ohio)
ABSTRACT Pharmaceutical compositions, kits and methods for treating tumors such as glioma and cancers such as leukemia with (R)-2-hydroxyglutarate (R-2HG) are provided, along with therapeutic regimens including treatment of a patient suffering from glioma or leukemia with a MYC-signaling inhibitor followed by or cotemporaneous with treatment with R-2HG, and optionally other chemotherapeutic agents.
FILED Thursday, October 14, 2021
APPL NO 17/501692
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 31/194 (20130101) Original (OR) Class
A61K 31/203 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/02 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062222 Elmaleh et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) David R. Elmaleh (Newton, Massachusetts);  Timothy M. Shoup (Franklin, Massachusetts)
ABSTRACT Described herein are compounds and methods of treating or imaging a disease or disorder, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, ischemic stroke, and prion disease, comprising administering a therapeutically effective amount of a cromolyn ester.
FILED Tuesday, December 10, 2019
APPL NO 17/312810
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/352 (20130101) Original (OR) Class
A61K 51/0421 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062230 Thatcher et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois)
ASSIGNEE(S)
INVENTOR(S) Gregory R. Thatcher (Chicago, Illinois);  Rui Xiong (Chicago, Illinois);  Jiong Zhao (Chicago, Illinois);  Yunlong Lu (Chicago, Illinois);  Lauren Gutgesell (Chicago, Illinois);  Carlo Ivan Rosales (Chicago, Illinois);  Yanfeng Li (Chicago, Illinois)
ABSTRACT In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
FILED Wednesday, February 06, 2019
APPL NO 16/967188
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/138 (20130101)
A61K 31/167 (20130101)
A61K 31/277 (20130101)
A61K 31/397 (20130101) Original (OR) Class
A61K 31/565 (20130101)
A61K 31/566 (20130101)
A61K 31/573 (20130101)
A61K 31/4025 (20130101)
A61K 31/4196 (20130101)
A61K 31/4535 (20130101)
A61K 38/09 (20130101)
A61K 39/3955 (20130101)
A61K 45/06 (20130101)

General Methods of Organic Chemistry; Apparatus Therefor
C07B 2200/05 (20130101)

Heterocyclic Compounds
C07D 409/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062234 NGO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
ASSIGNEE(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
INVENTOR(S) John T. NGO (Cambridge, Massachusetts);  Mary DUNLOP (Newton, Massachusetts);  Elliot Parker TAGUE (Brookline, Massachusetts);  Nathan Michael TAGUE (Brookline, Massachusetts);  Alexander Michael MARZILLI (Cambridge, Massachusetts)
ABSTRACT The technology described herein is directed to polypeptide systems using drug-controlled peptide docking domains and cognate docking domain-binding peptides and their use to control cellular signaling, activity, and/or gene expression.
FILED Tuesday, August 31, 2021
APPL NO 17/462185
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/404 (20130101) Original (OR) Class
A61K 31/4965 (20130101)
A61K 31/5377 (20130101)
A61K 47/6425 (20170801)

Peptides
C07K 14/02 (20130101)
C07K 14/47 (20130101)
C07K 14/705 (20130101)
C07K 14/43595 (20130101)
C07K 2319/03 (20130101)
C07K 2319/60 (20130101)
C07K 2319/80 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062235 Kashyap et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Mayo Foundation for Medical Education and Research (Rochester, Minnesota);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Purna C. Kashyap (Rochester, Minnesota);  Michael Fischbach (Portola Valley, California);  Brianna B. Williams (Oakland, California)
ABSTRACT This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
FILED Thursday, April 08, 2021
APPL NO 17/225513
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/405 (20130101) Original (OR) Class
A61K 35/74 (20130101)
A61K 35/741 (20130101)
A61K 35/742 (20130101)
A61K 2035/115 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062243 GLENN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Jeffrey S. GLENN (Palo Alto, California);  Mark SMITH (San Francisco,, California);  Edward PHAM (Palo Alto, California);  The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Jeffrey S. GLENN (Palo Alto, California);  Mark SMITH (Stanford, California);  Edward PHAM (Stanford, California)
ABSTRACT Methods of treating a subject for cancer using a PI4-kinase inhibitor are provided. Also provided are methods of inhibiting PI4-kinase in a cancer cell to reduce cellular proliferation. The PI4-kinase inhibitor can be a compound that is a 5-aryl or heteroaryl-thiazole, e.g., as described herein. In certain embodiments, the PI4-kinase inhibitor is a substituted 2-amino-5-phenylthiazole or substituted 2-amino-5-pyridylthiazole compound. The subject compounds may be formulated or provided to a subject in combination with one or more additional anti-cancer agents. Use of PI4-kinase inhibitors in methods of reducing cellular proliferation and methods of treatment is provided in a variety of cancer cells and cancer subjects.
FILED Thursday, January 09, 2020
APPL NO 17/420252
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/426 (20130101) Original (OR) Class
A61K 31/427 (20130101)
A61K 31/4439 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062248 CRAVATT et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Vividion Therapeutics, Inc. (San Diego, California);  The Scripps Research Institute (La Jolla, California)
ASSIGNEE(S)
INVENTOR(S) Benjamin F. CRAVATT (La Jolla, California);  Matthew PATRICELLI (San Diego, California);  Dean STAMOS (San Diego, California);  Gabe SIMON (San Diego, California);  Benjamin HORNING (San Diego, California);  David WEINSTEIN (San Diego, California);  Ekaterina VINOGRADOVA (San Diego, California)
ABSTRACT Disclosed herein are compositions and methods for modulating cereblon neosubstrates. A small molecule modulator of Formula (I*), or a pharmaceutically acceptable salt or solvate thereof can be used to modulate cereblon neosubstrates.
FILED Tuesday, November 17, 2020
APPL NO 16/950697
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/397 (20130101)
A61K 31/439 (20130101)
A61K 31/445 (20130101) Original (OR) Class
A61K 31/501 (20130101)
A61K 31/4545 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062274 Liggett et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) University of South Florida (Tampa, Florida);  Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Stephen Liggett (Tampa, Florida);  James Leahy (Tampa, Florida);  Donghwa Kim (Tampa, Florida);  Steven An (Highland Park, New Jersey)
ABSTRACT Disclosed herein are compounds useful for treating obstructive lung diseases. The compounds are TAS2Rs agonists and may further be used to treat disorders and conditions implicated by TAS2R. In some instances the disclosed compounds can be used to treat asthma.
FILED Wednesday, September 01, 2021
APPL NO 17/464233
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/122 (20130101)
A61K 31/444 (20130101)
A61K 31/4745 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062278 Hulme et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) Arizona Board of Regents on Behalf of the Univeristy of Arizona (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S) Christopher Hulme (Tucson, Arizona);  Yeng-Jeng Shaw (Tucson, Arizona);  Vijay Gokhale (Tucson, Arizona)
ABSTRACT This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperazine (or similar) structure which function as antagonists of androgen receptor activity, and their use as therapeutics for the treatment of cancer (e.g., castration-resistant prostate cancer) and other conditions characterized with androgen receptor activity and/or androgen receptor expression.
FILED Wednesday, December 11, 2019
APPL NO 17/413139
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/454 (20130101)
A61K 31/496 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Heterocyclic Compounds
C07D 213/74 (20130101)
C07D 257/04 (20130101)
C07D 401/12 (20130101)
C07D 401/14 (20130101)
C07D 405/12 (20130101)
C07D 405/14 (20130101)
C07D 409/14 (20130101)
C07D 413/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062291 Look et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S) Alfred T. Look (North Reading, Massachusetts);  Ken Morita (Boston, Massachusetts);  Eric S. Fischer (Chestnut Hill, Massachusetts);  Nathanael S. Gray (Boston, Massachusetts);  Shuning He (Boston, Massachusetts)
ABSTRACT Disclosed are compositions and methods of treating cancers by constitutively activating protein phosphatase 2A (PP2A) without blocking signaling through the dopamine D2 receptor, that entail administering a therapeutically effective amount of an analog of perphenazine (PPZ) of formula (I) or (II), or a related PPZ analog lacking dopamine receptor D2 inhibitory activity, or a pharmaceutically acceptable salt thereof.
FILED Thursday, December 19, 2019
APPL NO 17/415429
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/538 (20130101)
A61K 31/5415 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 7/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062296 Gallagher et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) AGENEBIO, INC. (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Michela Gallagher (Baltimore, Maryland);  Sharon Rosenzweig-Lipson (East Brunswick, New Jersey)
ABSTRACT This disclosure relates to methods, uses, combinations, pharmaceutical compositions, combinations for use, and pharmaceutical compositions for use useful for treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), in combination with GABAA α5 receptor agonists, in treating cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, mild cognitive impairment (MCI), amnestic MCI (aMCI), age-associated memory impairment (AAMI), age related cognitive decline (ARCD), dementia, Alzheimer's disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, bipolar disorder, amyotrophic lateral sclerosis, cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease, autism, compulsive behavior, and substance addiction. Further, the disclosure relates to methods, uses, combinations, pharmaceutical compositions, combinations for use, and pharmaceutical compositions for use useful for treating cognitive impairment associated with brain cancer or for treating brain cancer itself in a subject in need thereof. Additionally, the disclosure relates to methods, uses, combinations, pharmaceutical compositions, combinations for use, and pharmaceutical compositions for use useful for treating Parkinson's disease psychosis in a subject in need thereof.
FILED Friday, July 09, 2021
APPL NO 17/372405
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/5517 (20130101) Original (OR) Class
A61K 45/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062299 Quattrocelli et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) NORTHWESTERN UNIVERSITY (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Mattia Quattrocelli (Chicago, Illinois);  Alexis R. Demonbreun (Mokena, Illinois);  Elizabeth M. McNally (Oak Park, Illinois)
ABSTRACT Chronic glucocorticoid steroids produce muscle atrophy, but intermittent steroid exposure can promote muscle growth and function. It is disclosed herein that, in contrast to daily administration of a steroid, once-weekly steroid administration improved muscle mass and exercise tolerance in normal subjects as well as multiple models of muscle disease.
FILED Thursday, December 26, 2019
APPL NO 17/416792
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/573 (20130101) Original (OR) Class
A61K 38/1709 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 21/06 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062307 Miller et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
ASSIGNEE(S) Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
INVENTOR(S) Jordan D. Miller (Rochester, Minnesota);  Bin Zhang (Rochester, Minnesota)
ABSTRACT This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.
FILED Monday, November 08, 2021
APPL NO 17/521453
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/197 (20130101)
A61K 31/416 (20130101)
A61K 31/506 (20130101)
A61K 31/519 (20130101)
A61K 31/635 (20130101) Original (OR) Class
A61K 31/4985 (20130101)
A61K 31/5377 (20130101)
A61K 45/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062320 WISNIEWSKI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Non-Profit Organization (NPO)
Alzheimer's Disease and Related Disorders Association, Inc. (ADRDA)
APPLICANT(S) NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Thomas WISNIEWSKI (Staten Island, New York);  Daryl SPINNER (Staten Island, New York);  Henrieta SCHOLTZOVA (Fords, New Jersey);  Richard KASCSAK (Morganville, New Jersey)
ABSTRACT The present invention is directed to a method of preventing or reducing amyloid deposition in a subject. This method involves selecting a subject with amyloid deposits and stimulating the innate immune system of the selected subject under conditions effective to reduce the amyloid deposits. Also disclosed is a method of preventing or treating cerebral amyloidosis and Alzheimer's Disease in a subject by administering to the selected subject an agent that stimulates the innate immune system. In addition, a composition useful for the stimulation of the innate immune system of a subject exhibiting symptoms associated with amyloid deposition is disclosed.
FILED Thursday, February 25, 2021
APPL NO 17/184758
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7088 (20130101) Original (OR) Class
A61K 48/00 (20130101)
A61K 2039/57 (20130101)
A61K 2039/545 (20130101)
A61K 2039/55561 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101)
C12N 15/117 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062322 Ray et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Anuradha Ray (Pittsburgh, Pennsylvania);  Prabir Ray (Pittsburgh, Pennsylvania);  Sally Ellen Wenzel (Pittsburgh, Pennsylvania);  Timothy B. Oriss (Pittsburgh, Pennsylvania)
ABSTRACT Methods are provided for treating corticosteroid-resistant asthma in a patient, comprising decreasing Interferon Regulatory Factor 5 (IRF5) activity in the patient. Antisense or RNA interference reagents and methods can be used to decrease IRF5 activity in the patient.
FILED Friday, September 03, 2021
APPL NO 17/466454
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/573 (20130101)
A61K 31/713 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 11/06 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062324 Singh et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Anirudha Singh (Baltimore, Maryland);  Shimon Unterman (Brookline, Massachusetts);  Michael Corvelli (Baltimore, Maryland);  Jennifer Elisseeff (Baltimore, Maryland)
ABSTRACT The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (HA). The biomaterial compositions utilize small HA binding peptides and extracellular matrix binding (ECM) peptides that are tethered to synthetic biocompatible polymers. When tethered to the polymers, the peptide region allows the polymers to bind to HA and to tissues such as cartilage. The novel biomaterial compositions can be used to coat or chemically modify cartilage or tissues with a biologically compatible polymer having HA binding peptides, which allow HA to bind to the surface of the cartilage or tissues. Methods of using same are also provided.
FILED Friday, August 27, 2021
APPL NO 17/459201
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/0048 (20130101)
A61K 31/728 (20130101) Original (OR) Class
A61K 38/08 (20130101)
A61K 38/10 (20130101)
A61K 47/60 (20170801)
A61K 47/6957 (20170801)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/20 (20130101)
A61L 27/227 (20130101)
A61L 2400/10 (20130101)
A61L 2400/18 (20130101)
A61L 2430/06 (20130101)
A61L 2430/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062325 Boye et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S) Shannon E. Boye (Gainesville, Florida);  Sanford L. Boye (Gainesville, Florida)
ABSTRACT Disclosed herein are compositions of rAAV particles and methods for administrating rAAV particles having enhanced transduction properties.
FILED Tuesday, September 07, 2021
APPL NO 17/467555
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 9/5184 (20130101)
A61K 31/728 (20130101) Original (OR) Class
A61K 35/761 (20130101)
A61K 2039/5258 (20130101)
A61K 2800/91 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 17/00 (20180101)

Peptides
C07K 16/2875 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062336 Morrison
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltmore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Brett Morrison (Baltimore, Maryland)
ABSTRACT Provided herein are methods and compositions for increasing nerve regeneration activity of a macrophage, and for inducing and accelerating nerve regeneration of an injured or damaged nerve. Methods and compositions provided herein include upregulating the expression of an MCT1 gene in a macrophage.
FILED Wednesday, August 25, 2021
APPL NO 17/412127
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/15 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/00 (20180101)

Peptides
C07K 14/47 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062337 Jain
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S) Sandeep Jain (Chicago, Illinois)
ABSTRACT The present disclosure provides an ophthalmic formulation comprising one or more pharmaceutically acceptable excipients; a pharmaceutically active compound that is capable of reducing the amount or deleterious actions of autoantibodies on the ocular surface, such as IgG; In particular, the present disclosure provides an ophthalmic formulation where the pharmaceutically active compound is capable of treating a clinical condition selected from the group consisting of inflammatory, infectious and immunological ocular surface or intraocular disease that can cause symptoms of ocular discomfort, keratitis, dry eye disease, symblepheron formation, fornix foreshortening, eyelid margin/conjunctival keratinization, subconjunctival fibrosis, retinal gliosis and glaucoma.
FILED Friday, November 08, 2019
APPL NO 17/292094
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/16 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/02 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062357 Suresh et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Purdue Research Foundation (West Lafayetter, Indiana);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Rockville, Maryland)
ASSIGNEE(S) Purdue Research Foundation (West Lafayetter, Indiana);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Rockville, Maryland)
INVENTOR(S) Mittal Suresh (West Lafayette, Indiana);  Suryaprakash Sambhara (Atlanta, Georgia);  Weiping Cao (Atlanta, Georgia);  Wadzanai Mboko (Atlanta, Georgia);  Ekramy Sayedahmed (West Lafayette, Indiana)
ABSTRACT The present disclosure provides method and composition for protection, prevention, and/or treatment against viral infections via activation of ILCs induced by certain virus, including but not limited to, influenza and/or non-replicating adenoviruses. The present disclosure further provides that activation of ILCs is an intervention strategy against not only influenza viral infectious epidemic and/or pandemic before a strain-matched vaccine is available but also against other viruses for which prophylactic vaccines may not be available.
FILED Tuesday, August 24, 2021
APPL NO 17/409962
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/761 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/12 (20180101)
A61P 31/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062375 STINCHCOMB et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) TAKEDA VACCINES, INC. (Cambridge, Massachusetts);  THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT (Atlanta, Georgia)
ASSIGNEE(S) TAKEDA VACCINES, INC. (Cambridge, Massachusetts);  THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT (Atlanta, Georgia)
INVENTOR(S) Dan T. STINCHCOMB (Enumclaw, Washington);  Claire KINNEY (Fort Collins, Colorado);  Richard M. KINNEY (Fort Collins, Colorado);  Jill A. LIVENGOOD (Fort Collins, Colorado)
ABSTRACT Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition. In certain embodiments, compositions can include constructs of one or more serotypes of dengue virus, such as dengue-1 (DEN-1) virus, dengue-2 (DEN-2) virus, dengue-3 (DEN-3) or dengue-4 (DEN-4) virus constructs. In other embodiments, constructs disclosed herein can be combined in a composition to generate a vaccine against more one or more dengue virus constructs that may or may not be subsequently passaged in mammalian cells.
FILED Friday, September 17, 2021
APPL NO 17/478537
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101)
A61K 31/7048 (20130101)
A61K 38/162 (20130101) Original (OR) Class
A61K 39/12 (20130101)
A61K 2039/5254 (20130101)

Peptides
C07K 14/005 (20130101)
C07K 14/1825 (20130101)
C07K 19/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/09 (20130101)
C12N 15/8613 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062376 Debinski et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Wake Forest University Health Sciences (Winston-Salem, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Waldemar Debinski (Winston-Salem, North Carolina);  Jill Wykosky (La Jolla, California);  Denise Mazess Herpai (Winston-Salem, North Carolina)
ABSTRACT The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
FILED Tuesday, November 16, 2021
APPL NO 17/527835
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 38/45 (20130101)
A61K 38/177 (20130101) Original (OR) Class
A61K 38/2086 (20130101)
A61K 45/06 (20130101)
A61K 47/64 (20170801)
A61K 47/642 (20170801)
A61K 47/6801 (20170801)
A61K 49/0002 (20130101)

Peptides
C07K 14/52 (20130101)
C07K 14/705 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062385 Gladwin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Mark Gladwin (Pittsburgh, Pennsylvania);  Michael Jurczak (Pittsburgh, Pennsylvania);  Courtney E. Sparacino-Watkins (Pittsburgh, Pennsylvania)
ABSTRACT A method of treating hyperglycemia, diabetes, metabolic syndrome, insulin resistance (insulin insensitivity), impaired glucose tolerance, high glucose levels, pulmonary hypertension, and/or a condition arising from any of the foregoing in a patient is provided. The method comprises knocking down mARC2 or mARC1 expression in the patient, or otherwise decreasing mARC2 and mARC1 activity in the patient.
FILED Tuesday, July 27, 2021
APPL NO 17/386127
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7105 (20130101)
A61K 38/28 (20130101) Original (OR) Class
A61K 48/0016 (20130101)
A61K 48/0066 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/10 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062389 Spiegelman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Bruce M. Spiegelman (Waban, Massachusetts);  Christiane D. Wrann (Medford, Massachusetts)
ABSTRACT The invention provides methods for identifying, assessing, preventing, and treating neurological disorders and diseases using Fndc5 and modulators of Fndc5 expression or activity.
FILED Monday, September 13, 2021
APPL NO 17/473362
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/39 (20130101) Original (OR) Class
A61K 38/1709 (20130101)
A61K 48/00 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5023 (20130101)
G01N 33/5058 (20130101)
G01N 33/6896 (20130101)
G01N 2333/78 (20130101)
G01N 2800/28 (20130101)
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062391 Dean
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) UNIVERSITY OF ROCHESTER (Rochester, New York)
ASSIGNEE(S)
INVENTOR(S) David Dean (Rochester, New York)
ABSTRACT The present invention relates to improvement of epithelial or endothelial barrier function by increasing a level of myotonic dystrophy kinase-related Cdc42-binding kinases a (MRCKalpha) in one or more cells in the barrier.
FILED Wednesday, January 15, 2020
APPL NO 17/420732
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/45 (20130101) Original (OR) Class
A61K 38/46 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 11/00 (20180101)

Enzymes
C12Y 207/11001 (20130101)
C12Y 306/01 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062393 Byrne et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
ASSIGNEE(S) Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
INVENTOR(S) Guerard W. Byrne (Rochester, Minnesota);  Christopher G.A. McGregor (Rochester, Minnesota)
ABSTRACT This document provides methods and materials involved in reducing cardiac xenograft rejection. For example, methods and materials for preparing transgenic pigs expressing reduced or no endogenous Sda or SDa-like glycans derived from the porcine β1,4 N-acetyl-galactosaminyl transferase 2 (B4GALNT2) glycosyltransferase and/or reduced or no endogenous α-Gal antigens, methods and materials for modifying the xenograft recipient's immunological response to non-Gal antigens (e.g. CD46, CD59, CD9, PROCR, and ANXA2) to reduce cardiac xenograft rejection, and methods and materials for monitoring the progress of xenotransplant immunologic rejection are provided.
FILED Friday, August 27, 2021
APPL NO 17/459410
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0276 (20130101)
A01K 2207/30 (20130101)
A01K 2227/108 (20130101)
A01K 2267/02 (20130101)
A01K 2267/025 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 35/34 (20130101)
A61K 38/00 (20130101)
A61K 39/001 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/8509 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062394 Ouspenskaia et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  The General Hospital Corporation (Boston, Massachusetts);  Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Tamara Ouspenskaia (Cambridge, Massachusetts);  Travis Law (Cambridge, Massachusetts);  Aviv Regev (Cambridge, Massachusetts);  Steven Carr (Cambridge, Massachusetts);  Karl Clauser (Cambridge, Massachusetts);  Susan Klaeger (Cambridge, Massachusetts);  Nir Haochen (Boston, Massachusetts);  Catherine J. Wu (Boston, Massachusetts);  Derin Keskin (Boston, Massachusetts)
ABSTRACT Disclosed herein are polypeptides and compositions comprising one or more neoantigens, methods of identifying neoantigens, and methods for preparing a neoantigen for an immunogenic pharmaceutical composition. The neoantigen can be specific to a subject that has a cancer, disease, or other disorder.
FILED Thursday, December 12, 2019
APPL NO 17/414480
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/0005 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6869 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6848 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062401 Jin et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Rongsheng Jin (Irvine, California);  Philip Felgner (Irvine, California);  Peng Chen (Irvine, California)
ABSTRACT Methods and compositions for treating or preventing C. difficile infection (CDI) through TcdB or TcdA holotoxins. The compositions feature immunogens or binding agents, such as antibodies, nanobodies (VHHs), single-domain antibodies (sdAbs), etc., based on one or a combination of neutralizing epitopes of TcdB or TcdA. Where immunogens inhibit the conformational changes necessary for pore formation by TcdB at an endosomal pH. Additionally, immunogens inhibit the movement of the scissile bond into the CPD cleavage side and a proper orientation of GTD relative to CPD, thus inhibiting cleavage of the GTD, which is required to activate the toxin. The present invention also describes vaccines for treatment of CDI, e.g., vaccines that target TcdB or TcdA.
FILED Friday, November 19, 2021
APPL NO 17/531058
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/08 (20130101) Original (OR) Class

Peptides
C07K 14/33 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062428 Miller et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Miles A. Miller (Medford, Massachusetts);  Ralph Weissleder (Peabody, Massachusetts);  Hannes Mikula (Pixendorf, Austria)
ABSTRACT The present application provides a compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein L1, L2, L3, n, m, p, X, T, TR, and D are as described herein. Methods of using of these compounds to treat diseases advantageously treatable by drug D are also described.
FILED Thursday, December 12, 2019
APPL NO 17/312712
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/60 (20170801) Original (OR) Class
A61K 47/542 (20170801)
A61K 47/6937 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062432 Shah et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Sagar Ramesh Shah (Clemson, South Carolina);  Juan Carlos Martinez-Gutierrez (Baltimore, Maryland);  Alejandro Ruiz-Valls (Baltimore, Maryland);  Ran Lin (Baltimore, Maryland);  Honggang Cui (Lutherville, Maryland);  Alfredo Quinones-Hinojosa (Bel Air, Maryland)
ABSTRACT The present invention provides compositions comprising Verteporfin and other anticancer compounds linked to a hydrophilic peptide through a degradable linker molecule to allow the anticancer compounds to penetrate tissues via in situ administration. The compounds of the present invention are useful for sensitizing tumor cells to radiotherapy, preventing recurrence of tumors after surgical resection and for treating remaining unremoved cancer cells at the site of the tumor.
FILED Friday, September 10, 2021
APPL NO 17/471592
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/409 (20130101)
A61K 41/0038 (20130101)
A61K 47/64 (20170801) Original (OR) Class
A61K 47/6903 (20170801)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/10 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062440 Muschol
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of South Florida (Tampa, Florida)
ASSIGNEE(S)
INVENTOR(S) Martin Matthias Muschol (Tampa, Florida)
ABSTRACT Amyloids have been known to arise from many different proteins and polypeptides. These polypeptide chains generally form β-sheet structures that aggregate into long fibers; however, identical polypeptides can fold into multiple distinct amyloid conformations. The diversity of the conformations may have led to different forms of the prion diseases. In particular, large populations of small globular amyloid oligomers (gOs) and curvilinear fibrils (CFs) precede the formation of late-stage rigid fibrils (RFs), and have been implicated in amyloid toxicity. As disclosed herein, triarylmethane f dye crystal violet is a highly selective indicator of gOs and CFs. Therefore, disclosed herein are compositions, kits, and methods for detecting amyloids in a tissue, either in vitro or in vivo.
FILED Friday, December 13, 2019
APPL NO 17/312690
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0023 (20130101) Original (OR) Class

Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 11/08 (20130101)
C09B 11/12 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6839 (20130101)
G01N 2333/4709 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062547 El-Khatib et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) BETA BIONICS, INC. (Irvine, California)
ASSIGNEE(S)
INVENTOR(S) Firas H. El-Khatib (Allston, Massachusetts);  Edward R. Damiano (Acton, Massachusetts)
ABSTRACT A blood glucose control system can generate an indication of total carbohydrate therapy over a period during use by a subject. The system can be connected to a medicament pump configured to deliver insulin therapy, other types of medicament therapy, or a combination of medicament therapies to the subject. The system can determine an amount of a counter-regulatory agent to respond to an impending risk of hypoglycemia or an episode of hypoglycemia and determine a dose of carbohydrate therapy based at least in part on the amount of the counter-regulatory agent. The system can track determined doses of carbohydrate therapy to generate the indication of total carbohydrate therapy over the period.
FILED Wednesday, June 16, 2021
APPL NO 17/349219
CURRENT CPC
Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/1723 (20130101) Original (OR) Class
A61M 5/14244 (20130101)
A61M 2005/1726 (20130101)
A61M 2005/14208 (20130101)
A61M 2205/16 (20130101)
A61M 2205/50 (20130101)
A61M 2205/52 (20130101)
A61M 2205/502 (20130101)
A61M 2205/505 (20130101)
A61M 2205/3553 (20130101)
A61M 2205/3561 (20130101)
A61M 2205/3584 (20130101)
A61M 2205/3592 (20130101)
A61M 2230/201 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/40 (20180101)
G16H 20/17 (20180101)
G16H 20/60 (20180101)
G16H 40/67 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062637 Joyner et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Research Resources (NCRR)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
ASSIGNEE(S) Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
INVENTOR(S) Michael J. Joyner (Rochester, Minnesota);  Bruce D. Johnson (Rochester, Minnesota);  Thomas P. Olson (Cannon Falls, Minnesota)
ABSTRACT This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.
FILED Friday, November 19, 2021
APPL NO 17/531379
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/245 (20130101)
A61K 31/4468 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/3611 (20130101)
A61N 1/36057 (20130101)
A61N 1/36114 (20130101) Original (OR) Class
A61N 1/36117 (20130101)
A61N 1/36146 (20130101)
A61N 2/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062906 Rosenberg
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S) PlantVax, Inc. (, None)
ASSIGNEE(S) PlantVax, Inc. (Rockville, Maryland);  PlantVax, Inc. (Rockville, Maryland)
INVENTOR(S) Yvonne J. Rosenberg (Washington, District of Columbia)
ABSTRACT This invention relates to a device that can be used is used to detect organophosphates and carbamate on surfaces including food, clothing (including as wearable pesticide detectors) and machinery.
FILED Wednesday, May 06, 2020
APPL NO 17/609376
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/523 (20130101)
B01L 3/527 (20130101) Original (OR) Class
B01L 2200/10 (20130101)
B01L 2200/16 (20130101)
B01L 2200/026 (20130101)
B01L 2200/0689 (20130101)
B01L 2300/043 (20130101)
B01L 2300/123 (20130101)
B01L 2300/0609 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/18 (20130101)
C12N 9/0071 (20130101)
C12N 9/80 (20130101)

Enzymes
C12Y 114/14001 (20130101)
C12Y 301/01001 (20130101)
C12Y 305/01005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220063110 KONG et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Development Command (USAMRDC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) The Board of Trustees of the University of Illinois (Urbana, Illinois);  Purdue Research Foundation (, None)
ASSIGNEE(S)
INVENTOR(S) Hyunjoon KONG (Urbana, Illinois);  Byoungsoo KIM (Urbana, Illinois);  Jonghwi LEE (Urbana, Illinois);  Chi Hwan LEE (West Lafayette, Indiana);  Min Ku KIM (Lafayette, Indiana)
ABSTRACT Provided herein are manipulators for handling fragile layers and related methods of handling using the manipulators. The manipulators comprise a contact surface with thermally responsive recess features and a microelectric heater in thermal contact with the contact surface. In this manner, the manipulator is an electrothermal manipulator, with changes in temperature providing a contact force to pick-up a transferable layer material and a release force to facilitate release of the transferable from the manipulator.
FILED Tuesday, August 31, 2021
APPL NO 17/462862
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 7/00 (20130101)
B25J 11/0095 (20130101)
B25J 15/008 (20130101) Original (OR) Class
B25J 19/0025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064112 Messick et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Troy E. Messick (Upper Darby, Pennsylvania);  Garry R. Smith (King of Prussia, Pennsylvania);  Allen B. Reitz (Lansdale, Pennsylvania);  Paul M. Lieberman (Wynnewood, Pennsylvania);  Mark E. McDonnell (Lansdale, Pennsylvania);  Yan Zhang (Fort Washington, Pennsylvania);  Marianne Carlsen (Yardley, Pennsylvania);  Shuai Chen (Philadelphia, Pennsylvania)
ABSTRACT The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.
FILED Friday, April 16, 2021
APPL NO 17/232511
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/41 (20130101)
A61K 31/404 (20130101)
A61K 31/422 (20130101)
A61K 31/426 (20130101)
A61K 31/427 (20130101)
A61K 31/433 (20130101)
A61K 31/435 (20130101)
A61K 31/437 (20130101)
A61K 31/454 (20130101)
A61K 31/496 (20130101)
A61K 31/501 (20130101)
A61K 31/506 (20130101)
A61K 31/517 (20130101)
A61K 31/519 (20130101)
A61K 31/541 (20130101)
A61K 31/551 (20130101)
A61K 31/4155 (20130101)
A61K 31/4375 (20130101)
A61K 31/4439 (20130101)
A61K 31/4725 (20130101)
A61K 31/5377 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/20 (20180101)
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 209/08 (20130101) Original (OR) Class
C07D 277/62 (20130101)
C07D 401/10 (20130101)
C07D 401/12 (20130101)
C07D 401/14 (20130101)
C07D 403/10 (20130101)
C07D 403/12 (20130101)
C07D 403/14 (20130101)
C07D 405/12 (20130101)
C07D 405/14 (20130101)
C07D 409/12 (20130101)
C07D 413/10 (20130101)
C07D 417/10 (20130101)
C07D 417/12 (20130101)
C07D 471/04 (20130101)
C07D 471/08 (20130101)
C07D 471/10 (20130101)
C07D 487/04 (20130101)
C07D 487/08 (20130101)
C07D 491/107 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064118 Amaravadi et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Trustees of the University ofPennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Ravi K. Amaravadi (Media, Pennsylvania);  Jeffrey D. Winkler (Wynnewood, Pennsylvania)
ABSTRACT The invention provides novel asymmetric and symmetric bisaminoquinolmes and related compounds, methods of treatment and syntheses. The novel compounds exhibit effective anticancer activity and are useful in the treatment of a variety of autophagy-related disorders.
FILED Tuesday, April 13, 2021
APPL NO 17/229012
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/436 (20130101)
A61K 31/506 (20130101)
A61K 31/517 (20130101)
A61K 31/519 (20130101)
A61K 31/704 (20130101)
A61K 31/4375 (20130101)
A61K 31/4545 (20130101)
A61K 31/4706 (20130101)
A61K 31/4709 (20130101)
A61K 31/4745 (20130101)
A61K 31/4995 (20130101)
A61K 31/7056 (20130101)

Heterocyclic Compounds
C07D 215/46 (20130101) Original (OR) Class
C07D 401/12 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064151 Tsai et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts)
INVENTOR(S) Li-Huei Tsai (Cambridge, Massachusetts);  Ling Pan (Charlestown, Massachusetts);  Stephen J. Haggarty (Gloucester, Massachusetts);  Debasis Patnaik (Weymouth, Massachusetts)
ABSTRACT The present invention provides compounds of Formulae (A), (B), (C), and (D), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, pharmaceutical compositions thereof, and kits thereof. The present invention further provides methods of using the compounds to treat or prevent neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS (amyotrophic lateral sclerosis), traumatic brain injury, ischemic brain injury, stroke, frontal temporal dementia, Pick's disease, corticobasal degeneration, supra cerebral palsy, prion diseases (e.g., Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinker syndrome, Fatal Familial Insomnia, and Kuru), Nieman Pick type C, spinal cerebellar ataxia, spinal muscular dystrophy, ataxia telangiectasia, hippocampal sclerosis, Cockayne syndrome, Werner syndrome, xeroderma pigmentosaum, and Bloom syndrome. In one aspect, the methods include administering to a subject in need of treatment for a neurological disorder a therapeutically effective amount of DAC-001, DAC-002, DAC-003, DAC-009, or DAC-012, or a compound of Formula (A), (B), (C), or (D).
FILED Monday, August 09, 2021
APPL NO 17/397752
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 217/58 (20130101)
C07C 219/28 (20130101)

Heterocyclic Compounds
C07D 307/40 (20130101)
C07D 307/52 (20130101)
C07D 405/12 (20130101) Original (OR) Class
C07D 409/12 (20130101)
C07D 411/12 (20130101)
C07D 487/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064152 BROWN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
ASSIGNEE(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
INVENTOR(S) Lauren E. BROWN (Waltham, Massachusetts);  Kaddy CAMARA (Revere, Massachusetts);  Leah E. COWEN (ON, Canada);  John A. PORCO, JR. (Brookline, Massachusetts)
ABSTRACT The present invention is directed to compounds, compositions, and methods for inhibiting drug-efflux pumps. The compounds, compositions, and methods can be used for enhancing the activity of therapeutic agents that are efflux pump substrates and for the treatment of drug-resistant diseases or disorders, such as microbial infections and cancers.
FILED Tuesday, August 31, 2021
APPL NO 17/462550
CURRENT CPC
Heterocyclic Compounds
C07D 405/14 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064174 Natarajan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) CITY OF HOPE (Duarte, California)
ASSIGNEE(S)
INVENTOR(S) Rama Natarajan (Hacienda Heights, California);  Feng Miao (Alhambra, California);  Nagarajan Vaidehi (Arcadia, California);  Supriyo Bhattacharya (Monrovia, California)
ABSTRACT Disclosed herein, inter alia, are compounds and methods for inhibiting the thioredoxin-thioredoxin-interacting-protein (TXNIP-TRX) complex.
FILED Thursday, April 15, 2021
APPL NO 17/231743
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 3/10 (20180101)
A61P 37/06 (20180101)

Heterocyclic Compounds
C07D 491/048 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064176 SARLAH et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) David SARLAH (Champaign, Illinois);  Tanner W. BINGHAM (Urbana, Illinois);  Lucas William HERNANDEZ (Urbana, Illinois);  The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S) The Board of Trustees of the University of Illinois (Urbana, Illinois)
INVENTOR(S) David SARLAH (Champaign, Illinois);  Tanner W. BINGHAM (Urbana, Illinois);  Lucas William HERNANDEZ (Urbana, Illinois)
ABSTRACT Enantioselective total syntheses of the anticancer isocarbostyril alkaloids (+)-7-deoxypancratistatin, (+)-pancratistatin, (+)-lycoricidine, and (+)-narciclasine are described. Our strategy for accessing this unique class of natural products is based on the development of a Ni-catalyzed dearomative trans-1,2-carboamination of benzene. The effectiveness of this dearomatization approach is notable, as only two additional olefin functionalizations are needed to construct the fully decorated aminocyclitol cores of these alkaloids. Installation of the lactam ring has been achieved through several pathways and a direct interconversion between natural products was established via a late-stage C-7 cupration. Using this synthetic blueprint, we were able to produce natural products on a gram scale and provide tailored analogs with improved activity, solubility, and metabolic stability.
FILED Wednesday, December 04, 2019
APPL NO 17/299365
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 31/22 (20130101)
B01J 2531/16 (20130101)

Heterocyclic Compounds
C07D 491/056 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064177 Nathanson et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) David A. Nathanson (Los Angeles, California);  Michael E. Jung (Los Angeles, California);  Jonathan Tsang (Los Angeles, California);  Lorenz Urner (Los Angeles, California);  Peter M. Clark (Los Angeles, California);  Timothy F. Cloughesy (Calabasas, California);  Gyudong Kim (Seoul, South Korea)
ABSTRACT The present disclosure relates to compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating glioblastoma and other EGFR-mediated cancers, such as those that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.
FILED Tuesday, September 14, 2021
APPL NO 17/475144
CURRENT CPC
General Methods of Organic Chemistry; Apparatus Therefor
C07B 2200/05 (20130101)

Heterocyclic Compounds
C07D 239/94 (20130101)
C07D 239/95 (20130101)
C07D 405/04 (20130101)
C07D 491/056 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064214 DEWJI
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) CENNA BIOSCIENCES INC. (La Jolla, California)
ASSIGNEE(S) CENNA BIOSCIENCES INC. (La Jolla, California)
INVENTOR(S) Nazneen DEWJI (San Diego, California)
ABSTRACT A peptide comprising a sequence of Ac-DEEEDEEL-NH2, a sequence of dEEEDEEL-NH2 or a sequence of Ac-dEEEDEEL-NH2, a pharmaceutical composition comprising the peptide, and use of the peptide for treating a disease or disorder.
FILED Monday, January 06, 2020
APPL NO 17/420927
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Peptides
C07K 7/06 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064222 Kwong et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
ASSIGNEE(S) The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
INVENTOR(S) Peter Kwong (Washington, District of Columbia);  Barney Graham (Rockville, Maryland);  John Mascola (Rockville, Maryland);  Li Ou (Potomac, Maryland);  Aliaksandr Druz (Germantown, Maryland);  Man Chen (Bethesda, Maryland);  Wing-Pui Kong (Germantown, Maryland);  Ivelin Stefanov Georgiev (Nashville, Tennessee);  Emily Rundlet (New York, New York);  Michael Gordon Joyce (Washington, District of Columbia);  Yaroslav Tsybovsky (Frederick, Maryland);  Paul Thomas (Washington, District of Columbia);  Marie Pancera (Seattle, Washington);  Mallika Sastry (Rockville, Maryland);  Cinque Soto (Nashville, Tennessee);  Joseph Van Galen (North Wales, Pennsylvania);  Guillaume Stewart-Jones (Cambridge, Massachusetts);  Yongping Yang (Potomac, Maryland);  Baoshan Zhang (Bethesda, Maryland);  Ulrich Baxa (Frederick, Maryland)
ABSTRACT Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.
FILED Thursday, November 11, 2021
APPL NO 17/524380
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 2039/5252 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)
A61P 37/04 (20180101)

Peptides
C07K 14/005 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 2760/18522 (20130101)
C12N 2760/18534 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064236 KO et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) Elixirgen, LLC (Baltimore, Maryland);  The United States of America, as Represented by the Secretary for the Department of Health and Human (Bethesda, Maryland)
ASSIGNEE(S) Elixirgen, LLC (Baltimore, Maryland);  The United States of America, as Represented by the Secretary for the Department of Health and Human (Bethesda, Maryland)
INVENTOR(S) Minoru S.H. KO (Cockeysville, Maryland);  Tomokazu AMANO (Parkville, Maryland)
ABSTRACT Described herein is the finding that increasing the frequency of Zscan4 activation in mouse ES cells not only enhances, but also maintains their developmental potency in long-term cell culture. As the potency increases, even a whole animal can be produced from a single ES cell injected into a 4N blastocyst at an unexpectedly high success rate. The studies disclosed herein indicate that ES cells acquire higher potency by going through the transient Zscan4 activation state more frequently than the regular state. Particularly disclosed herein is the finding that the constitutive presence of Zscan4-ERT2, even in the absence of its usual activator tamoxifen, can increase the frequency of endogenous Zscan4 activation in ES cells, resulting in the increase of developmental potency of the ES cells. Accordingly, provided herein are Zscan4-ERT2 fusion proteins and nucleic acid molecules and vectors encoding Zscan4-ERT2 fusion proteins. Further provided are methods of prolonging and/or enhancing stem cell pluripotency using the disclosed Zscan4-ERT2 nucleic acid molecules and fusion proteins.
FILED Monday, November 15, 2021
APPL NO 17/527006
CURRENT CPC
Peptides
C07K 14/47 (20130101) Original (OR) Class
C07K 14/721 (20130101)
C07K 14/70567 (20130101)
C07K 2319/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0606 (20130101)
C12N 5/0696 (20130101)
C12N 15/62 (20130101)
C12N 15/79 (20130101)
C12N 15/85 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064238 Taatjes et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado);  Yale University (New Haven, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Dylan Taatjes (Boulder, Colorado);  Alanna Schepartz Shrader (Berkeley, California)
ABSTRACT The invention includes novel systems, methods, and compositions to inhibit TF function by disrupting the TF-Mediator interaction. In this preferred aspect, functional mimics of TF activation domains may be rationally designed to block TF-Mediator binding and selectively inhibited TF-dependent transcription and may further incorporate a penta-arg motif for enhanced cell penetration. In one preferred embodiment of the invention novel stapled mimetic peptides of p53 activation domains incorporating a penta-arg motif were rationally designed to block p53 function by disrupting the p53-Mediator interaction. Additional aspects of the invention include methods of treating cancer in a subject, and other diseases related to the activity of the TFs, such as p53, and the Mediator complex, and its downstream TF-dependent transcription.
FILED Wednesday, September 01, 2021
APPL NO 17/464469
CURRENT CPC
Peptides
C07K 14/4703 (20130101) Original (OR) Class
C07K 2317/31 (20130101)
C07K 2319/70 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064252 TAGUE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
ASSIGNEE(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
INVENTOR(S) Elliot Parker TAGUE (Brookline, Massachusetts);  John T. NGO (Boston, Massachusetts);  Jeffrey Blye MCMAHAN (Cambrige, Massachusetts)
ABSTRACT Described herein are methods and compositions related to modular engineered receptor polypeptide constructs and their use in modulating the activity of a cell.
FILED Friday, August 27, 2021
APPL NO 17/458739
CURRENT CPC
Peptides
C07K 14/705 (20130101) Original (OR) Class
C07K 2319/03 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064259 Liotta et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) GEORGE MASON RESEARCH FOUNDATION, INC. (Fairfax, Virginia)
ASSIGNEE(S)
INVENTOR(S) Lance Liotta (Fairfax, Virginia);  Alessandra Luchini Kunkel (Fairfax, Virginia);  Amanda Still (Fairfax, Virginia);  Mikell Paige (Fairfax, Virginia)
ABSTRACT The present disclosure relates to compounds, complexes, compositions, kits and methods for determining interacting and/or binding sites between e.g., proteins, proteins and nucleic acids, proteins and small molecules, or intrachain protein domains. The disclosure provides rapid and direct positive identification of the contact interface region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions.
FILED Friday, January 03, 2020
APPL NO 17/415190
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Acyclic or Carbocyclic Compounds
C07C 303/22 (20130101)
C07C 309/50 (20130101)

Peptides
C07K 7/06 (20130101)
C07K 7/08 (20130101)
C07K 14/70521 (20130101)
C07K 14/70532 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6845 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064293 Ring et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Aaron Michael Ring (New Haven, Connecticut);  Kenan Christopher Garcia (Menlo Park, California);  Kipp Andrew Weiskopf (Brookline, Massachusetts);  Aron M. Levin (Cambridge, Massachusetts);  Irving L. Weissman (Stanford, California)
ABSTRACT High affinity SIRP-α reagent are provided, which (i) comprise at least one amino acid change relative to the wild-type protein; and (ii) have an increased affinity for CD47 relative to the wild-type protein. Compositions and methods are provided for modulating phagocytosis in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity SIRPα reagent, which blocks the physiological binding interaction between SIRPα and its ligand CD47.
FILED Thursday, November 18, 2021
APPL NO 17/530287
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/16 (20130101)

Peptides
C07K 14/4703 (20130101)
C07K 16/2803 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064309 Durum et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland);  University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S) University of Maryland, College Park (College Park, Maryland);  The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland)
INVENTOR(S) Scott Durum (Frederick, Maryland);  Julie Hixon (Hagerstown, Maryland);  Wen Qing Li (Frederick, Maryland);  Scott Walsh (College Park, Maryland);  Lila Kashi (College Park, Maryland)
ABSTRACT Antibodies and antigen binding fragments that specifically bind to IL-7Rα are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7Rα using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7Rα, such as acute lymphoblastic leukemia.
FILED Monday, August 02, 2021
APPL NO 17/392075
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/39558 (20130101)
A61K 45/06 (20130101)

Peptides
C07K 16/2809 (20130101)
C07K 16/2866 (20130101) Original (OR) Class
C07K 2317/21 (20130101)
C07K 2317/31 (20130101)
C07K 2317/51 (20130101)
C07K 2317/54 (20130101)
C07K 2317/55 (20130101)
C07K 2317/76 (20130101)
C07K 2317/515 (20130101)
C07K 2317/565 (20130101)
C07K 2317/567 (20130101)
C07K 2317/622 (20130101)
C07K 2317/732 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57492 (20130101)
G01N 2333/7155 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064324 Ho et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
ASSIGNEE(S) The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland)
INVENTOR(S) Mitchell Ho (Urbana, Maryland);  Ira H. Pastan (Potomac, Maryland);  Jessica D. Hong (Herndon, Virginia);  Nan Li (Laurel, Maryland)
ABSTRACT Camel single-domain monoclonal antibodies that specifically bind human and mouse mesothelin are described. Chimeric antigen receptor (CAR) T cells and antibody conjugates based on the mesothelin-specific antibodies are also described. The disclosed CAR T cells, mesothelin-specific antibodies and conjugates thereof can be used, for example, in the diagnosis or treatment of mesothelin-positive cancers.
FILED Thursday, January 02, 2020
APPL NO 17/421334
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6851 (20170801)
A61K 47/6929 (20170801)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/71 (20130101)
C07K 14/7051 (20130101)
C07K 14/7153 (20130101)
C07K 14/70517 (20130101)
C07K 14/70578 (20130101)
C07K 16/30 (20130101) Original (OR) Class
C07K 16/2809 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064326 LIU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Rihe LIU (Chapel Hill, North Carolina);  Gianpietro DOTTI (Chapel Hill, North Carolina);  JingJing LI (Chapel Hill, North Carolina);  Jiyoung AHN (Chapel Hill, North Carolina)
ABSTRACT Provided herein are biepitopic or bispecific chimeric antigen receptors. The chimeric antigen receptors comprise a combination of single domain antibody mimics The single domain antibody mimics may be monobodies, affibodies, or DARPins. The disclosed chimeric antigen receptors may recognize two different epitopes of the same tumor antigen. For example, the chimeric antigen receptor may recognize two different epitopes of HER-2 or EGFR. The disclosed chimeric antigen receptors may recognize two epitopes of two different tumor antigens. For example, the chimeric antigen receptor may recognize HER-2 and EGFR. The disclosed chimeric antigen receptors may be expressed in immune cells for use in cancer immunotherapy.
FILED Friday, January 10, 2020
APPL NO 17/420251
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/7051 (20130101)
C07K 14/70517 (20130101)
C07K 14/70521 (20130101)
C07K 16/32 (20130101) Original (OR) Class
C07K 16/2863 (20130101)
C07K 2317/31 (20130101)
C07K 2317/569 (20130101)
C07K 2319/02 (20130101)
C07K 2319/03 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064451 HELGASON et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Office of Research and Development (DVAORD)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Non-Profit Organization (NPO)
Dystrophic Epidermolysis Bullosa Research Association of America (DEBRA of America)
APPLICANT(S) VitroLabs Inc (San Jose, California);  King's College London (London, United Kingdom)
ASSIGNEE(S)
INVENTOR(S) Ingvar HELGASON (San Jose, California);  Dusko ILIC (London, United Kingdom)
ABSTRACT Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.
FILED Friday, July 02, 2021
APPL NO 17/366550
CURRENT CPC
Compositions of Macromolecular Compounds
C08L 89/06 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0625 (20130101)
C12N 5/0629 (20130101)
C12N 5/0698 (20130101)
C12N 11/02 (20130101)
C12N 2501/155 (20130101)
C12N 2501/385 (20130101)
C12N 2502/13 (20130101)
C12N 2502/091 (20130101)
C12N 2502/094 (20130101)
C12N 2506/45 (20130101)
C12N 2533/30 (20130101)
C12N 2533/54 (20130101)

Chemical Treatment of Hides, Skins or Leather, e.g Tanning, Impregnating, Finishing; Apparatus Therefor; Compositions for Tanning
C14C 3/02 (20130101)
C14C 13/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064584 Sharei et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Armon R. Sharei (Watertown, Massachusetts);  Shirley Mao (Cambridge, Massachusetts);  George Hartoularos (Boston, Massachusetts);  Sophia Liu (Boston, Massachusetts);  Megan Heimann (Baltimore, Maryland);  Pamela Basto (Somerville, Massachusetts);  Gregory Szeto (Baltimore, Maryland);  Siddharth Jhunjhunwala (Bengaluru, India);  Darrell J. Irvine (Arlington, Massachusetts);  Robert S. Langer (Newton, Massachusetts);  Klavs F. Jensen (Lexington, Massachusetts);  Ulrich H. Von Andrian (Chestnut Hill, Massachusetts)
ABSTRACT A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
FILED Wednesday, August 04, 2021
APPL NO 17/394125
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/00 (20130101)
A61K 45/06 (20130101)
A61K 49/0017 (20130101)
A61K 2039/5158 (20130101)

Apparatus for Enzymology or Microbiology;
C12M 23/16 (20130101)
C12M 35/00 (20130101)
C12M 35/04 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0635 (20130101)
C12N 5/0636 (20130101)
C12N 5/0639 (20130101)
C12N 15/87 (20130101)
C12N 2501/05 (20130101)
C12N 2501/998 (20130101)
C12N 2510/00 (20130101)
C12N 2527/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5047 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064602 Wells et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Children's Hospital Medical Center (Cincinnati, Ohio)
ASSIGNEE(S)
INVENTOR(S) James Wells (Cincinnati, Ohio);  Kyle McCracken (Cincinnati, Ohio)
ABSTRACT The instant disclosure relates to methods for converting mammalian definitive endoderm (DE) cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the disclosure relates to formation of gastric fundus tissue and/or organoids formed from differentiated definitive endoderm.
FILED Wednesday, July 14, 2021
APPL NO 17/375293
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0606 (20130101)
C12N 5/0607 (20130101)
C12N 5/0609 (20130101)
C12N 5/0679 (20130101) Original (OR) Class
C12N 2501/11 (20130101)
C12N 2501/115 (20130101)
C12N 2501/155 (20130101)
C12N 2501/385 (20130101)
C12N 2501/415 (20130101)
C12N 2506/03 (20130101)
C12N 2506/025 (20130101)
C12N 2506/45 (20130101)
C12N 2513/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064603 Vogt et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Caleb Darwin Vogt (Minneapolis, Minnesota);  Angela Panoskaltsis-Mortari (Woodbury, Minnesota)
ABSTRACT Devices, systems, and techniques are described for printing pre-aligned microtissues into larger tissue constructs. For example, a method of printing a tissue construct includes aligning cells in a first direction to create pre-aligned microtissues, suspending the pre-aligned microtissues in a liquid to create a bioink, and depositing the pre-aligned microtissues in a second direction to create the tissue construct.
FILED Tuesday, August 31, 2021
APPL NO 17/446563
CURRENT CPC
Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 80/00 (20141201)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0062 (20130101)
C12N 5/0697 (20130101) Original (OR) Class
C12N 2502/23 (20130101)
C12N 2502/28 (20130101)
C12N 2502/1347 (20130101)
C12N 2533/54 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064615 Fischetti et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Rockefeller University (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Vincent A. Fischetti (New York, New York);  Jonathan Schmitz (New York, New York);  Daniel Gilmer (New York, New York);  Chad Euler (New York, New York)
ABSTRACT The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.
FILED Wednesday, September 15, 2021
APPL NO 17/476030
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/47 (20130101)
A61K 38/50 (20130101)
A61K 38/162 (20130101)
A61K 45/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/2462 (20130101) Original (OR) Class

Enzymes
C12Y 302/01017 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064653 Roth et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Theodore Lee Roth (San Francisco, California);  Alexander Marson (San Francisco, California)
ABSTRACT Provided herein are methods and compositions for editing the genome of a cell. In some embodiments, a nucleotide sequence of at least 200 nucleotides in length is inserted into a target region in the genome of a cell.
FILED Monday, October 11, 2021
APPL NO 17/498531
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/90 (20130101)
C12N 15/102 (20130101)
C12N 15/1138 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
C12N 2320/53 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064669 Sullivan et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The Gov. of the U.S.A as Represented by the Secretary of the Department of Health and Human Services (Rockville, Maryland);  Sabin Vaccine Institute (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Nancy J. Sullivan (Kensington, Maryland);  Gary J. Nabel (Washington, District of Columbia);  Clement Asiedu (Olney, Maryland);  Cheng Cheng (Rockville, Maryland);  Alfredo Nicosia (Rome, Italy);  Riccardo Cortese (Rome, Italy);  Virginia Ammendola (Napoli, Italy);  Stefano Colloca (Rome, Italy)
ABSTRACT This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).
FILED Friday, July 30, 2021
APPL NO 17/389421
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 2039/545 (20130101)
A61K 2039/5254 (20130101)
A61K 2039/5256 (20130101)

Peptides
C07K 14/005 (20130101)
C07K 14/08 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 15/86 (20130101) Original (OR) Class
C12N 15/861 (20130101)
C12N 15/8636 (20130101)
C12N 2710/10341 (20130101)
C12N 2710/10343 (20130101)
C12N 2710/24111 (20130101)
C12N 2710/24141 (20130101)
C12N 2760/14111 (20130101)
C12N 2760/14134 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064676 Dever et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) Daniel P. Dever (Stanford, California);  Rasmus O. Bak (Stanford, California);  Ayal Hendel (Stanford, California);  Waracharee Srifa (Stanford, California);  Matthew H. Porteus (Stanford, California)
ABSTRACT In certain aspects, the present invention provides methods for inducing a stable gene modification of a target nucleic acid via homologous recombination in a primary cell, such as a primary blood cell and/or a primary mesenchymal cell. In certain other aspects, the present invention provides methods for enriching a population of genetically modified primary cells having targeted integration at a target nucleic acid. The methods of the present invention rely on the introduction of a DNA nuclease such as a Cas polypeptide and a homologous donor adeno-associated viral (AAV) vector into the primary cell to mediate targeted integration of the target nucleic acid. Also provided herein are methods for preventing or treating a disease in a subject in need thereof by administering to the subject any of the genetically modified primary cells or pharmaceutical compositions described herein to prevent the disease or ameliorate one or more symptoms of the disease.
FILED Friday, October 15, 2021
APPL NO 17/502479
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7115 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 7/00 (20180101)

Peptides
C07K 14/805 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0635 (20130101)
C12N 5/0636 (20130101)
C12N 5/0665 (20130101)
C12N 9/22 (20130101)
C12N 15/113 (20130101)
C12N 15/907 (20130101) Original (OR) Class
C12N 15/8645 (20130101)
C12N 2310/20 (20170501)
C12N 2310/311 (20130101)
C12N 2310/313 (20130101)
C12N 2310/3125 (20130101)
C12N 2750/14143 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064693 Justice et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California (UC BERKELEY) at Berkeley, CA
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Nicholas B. Justice (Oakland, California);  Adam P. Arkin (San Francisco, California)
ABSTRACT Disclosed herein are methods, compositions, and systems for determining specific microbial taxa, within a complex consortia of mixed taxa, which are interacting with each other in an environment of interest. In some embodiments, after diluting a sample comprising multiple different taxa of microorganisms, dilutions of the sample are cultivated for determining taxonomic information and interactions of multiple taxa of microorganisms in the sample.
FILED Monday, May 24, 2021
APPL NO 17/328167
CURRENT CPC
Beer; Preparation of Beer by Fermentation; Preparation of Malt for Making Beer; Preparation of Hops for Making Beer
C12C 1/02 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/02 (20130101) Original (OR) Class
C12Q 1/025 (20130101)
C12Q 1/689 (20130101)
C12Q 2600/158 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 40/00 (20190201)
G16B 40/20 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064697 Zhuang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Xiaowei Zhuang (Cambridge, Massachusetts);  Chenglong Xia (Cambridge, Massachusetts);  Jeffrey R. Moffitt (Cambridge, Massachusetts)
ABSTRACT The present invention generally relates to systems and methods for imaging or determining nucleic acids in cells or other samples. In some cases, the transcriptome of a cell may be determined. Certain embodiments are generally directed to determining nucleic acids and other targets in a sample at relatively high resolutions. For instance, nucleic acid probes may be applied to sample, and binding of the nucleic acid probes to a target may be amplified using primary and secondary amplifier nucleic acids. In some cases, there is a maximum number of amplifier nucleic acids that can be bound to a target, e.g., the binding is saturatable, and cannot grow indefinitely, even in the presence of abundant reagents. This may be advantageous, for example, for controlling the brightness of each binding event, controlling the size of the amplified regions (e.g., during imaging), and/or for limiting the degree of amplification noise (i.e. the final variation in amplified signal from molecule to molecule), etc. In addition, in some embodiments, the primary and/or secondary amplifier nucleic acids may be formed from only 3 of the 4 naturally-occurring nucleotides, which may result in less secondary structure, faster binding rates, etc. These properties can in some cases facilitate the rapid design of multiple orthogonal amplification sequences, allowing the extension of such an approach to many distinct molecular targets.
FILED Thursday, December 12, 2019
APPL NO 17/413148
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/682 (20130101) Original (OR) Class
C12Q 1/6841 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/64 (20130101)
G01N 2021/6439 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064699 Xuan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Feng Xuan (Cambridge, Massachusetts);  Peng Yin (Cambrige, Massachusetts);  Mingjie Dai (Cambrige, Massachusetts);  Xi Chen (Cambridge, Massachusetts)
ABSTRACT The present disclosure provides, in some embodiments, methods and compositions for single-molecule detection.
FILED Wednesday, November 10, 2021
APPL NO 17/523611
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6804 (20130101) Original (OR) Class

Combinatorial Chemistry; Libraries, e.g Chemical Libraries
C40B 70/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064715 Alland et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
INVENTOR(S) David Alland (Bernardsville, New Jersey);  Soumitesh Chakravorty (Somerset, New Jersey)
ABSTRACT The present invention relates to novel primers and sloppy molecular beacon and molecular beacon probes for amplifying segments from different genes in Mycobacterium tuberculosis for identifying the presence of M.tb DNA and/or resistance to anti-tuberculosis drugs.
FILED Tuesday, November 16, 2021
APPL NO 17/527576
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/686 (20130101)
C12Q 1/689 (20130101) Original (OR) Class
C12Q 1/6865 (20130101)
C12Q 2525/143 (20130101)
C12Q 2525/185 (20130101)
C12Q 2600/16 (20130101)
C12Q 2600/112 (20130101)
C12Q 2600/156 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064717 SIMS et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S) The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S) Peter A. SIMS (Ardsley, New York);  Sayantan BOSE (Collegeville, Pennsylvania);  Jinzhou YUAN (Edgewater, New Jersey)
ABSTRACT Many important biological questions demand single-cell transcriptions on a large scale. Hence, new tools are urgently needed for efficient, inexpensive manipulation of RNA from individual cells. Described herein are devices, systems and methods for trapping single-cell lysates in sealed, microwells capable of priming RNA on glass or capturing RNA on beads.
FILED Tuesday, September 21, 2021
APPL NO 17/480839
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6834 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064736 Hoque et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Mohammad O. Hoque (Towson, Maryland);  Masamichi Hayashi (Nagoya City, Japan);  Elisa Guida (Trieste, Italy)
ABSTRACT The invention provides methods for detecting a cellular proliferative disorder (e.g., urothelial cancer) in a subject by assessing the methylation status of the GULP1 promoter in a nucleic acid sample. The methods of the invention are useful for diagnostic, prognostic as well as therapeutic regimen predictions.
FILED Thursday, January 21, 2021
APPL NO 17/154249
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/711 (20130101)
A61K 31/7068 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/118 (20130101)
C12Q 2600/154 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064738 Ghobrial et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Irene Ghobrial (Wellesley, Massachusetts);  Salomon Manier (Lille, France);  Yuji Mishima (Tokyo, Japan)
ABSTRACT Provided herein are non-invasive methods and biomarkers that identify progression and clonal evolution of plasma cell dyscrasias. Also provided are materials and methods for the diagnosis, prognosis, staging, and monitoring of plasma cell dyscrasias based on the presence of the biomarkers in a blood biopsy, as well as methods for monitoring the progression of a plasma cell dyscrasia, determining the efficacy of a therapeutic agent, determining a targeted therapy related to a plasma cell dyscrasia, and/or treating a plasma cell dyscrasia. The methods provided herein provide several advantages over invasive biopsies.
FILED Friday, August 13, 2021
APPL NO 17/402018
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/02 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101)
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/112 (20130101)
C12Q 2600/118 (20130101)
C12Q 2600/154 (20130101)
C12Q 2600/156 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/574 (20130101)
G01N 33/5011 (20130101)
G01N 33/5038 (20130101)
G01N 33/5044 (20130101)
G01N 2570/00 (20130101)
G01N 2800/22 (20130101)
G01N 2800/52 (20130101)
G01N 2800/56 (20130101)
G01N 2800/60 (20130101)
G01N 2800/7028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065761 COON et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Joshua COON (Middleton, Wisconsin);  Michael WESTPHALL (Fitchburg, Wisconsin)
ABSTRACT The present invention provides methods for controllably forming a layer of amorphous ice and other amorphous solids on a substrate, and also provides cryo-electron microscopy (cryo-EM) sample preparation methods and systems that utilize in vacuo formation of amorphous ice and other solids. Formation of the amorphous solid layer can be independent of the deposition of sample molecules to be analyzed using electron microscopy, and allows for the generation of a uniformly thick layer. Optionally, mass spectrometry instruments are used to generate and purify molecules deposited on the generated amorphous solid layer. The techniques and systems described herein can deliver near ideal cryo-EM sample preparation to greatly increase resolution, sensitivity, scope, and throughput of cryo-EM protein imaging, and therefore greatly impact the field of structural biology.
FILED Thursday, July 01, 2021
APPL NO 17/365698
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/36 (20130101)
G01N 1/42 (20130101) Original (OR) Class
G01N 15/1468 (20130101)

Electric Discharge Tubes or Discharge Lamps
H01J 37/26 (20130101)
H01J 37/28 (20130101)
H01J 49/164 (20130101)
H01J 49/165 (20130101)
H01J 2237/31745 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065783 Cui
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Meng Cui (West Lafayette, Indiana)
ABSTRACT Systems and methods for analyzing samples, such as tissue samples, and measuring the emissions when these samples are exposed to light are disclosed. Embodiments include illuminating multiple target locations on a sample with laser light, which may first be manipulated by a scanner, and receiving decaying emissions from the target location. At least some embodiments include the emissions traveling backwards along a substantial portion of the laser light pathway and being received by a detector. Additional embodiments include converting the received emissions into streak lines of position versus time, converting the streak lines to plots of signal strength versus time, and curve fitting the plots to determine representative decay times. In some embodiments, the decay times are presented as plots of position on the surface of the sample versus emission strength, which may be color coded. Some embodiment dwell on each target location for multiple scans of the laser.
FILED Wednesday, August 25, 2021
APPL NO 17/445945
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6408 (20130101) Original (OR) Class
G01N 2201/1053 (20130101)
G01N 2201/06113 (20130101)

Image Data Processing or Generation, in General
G06T 11/001 (20130101)
G06T 11/206 (20130101)

Pictorial Communication, e.g Television
H04N 5/2256 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065816 Ibrahim et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Pacific Northwest National Laboratory (PNNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Memorial Institute (BMI) at Richland, WA
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Yehia M. Ibrahim (West Richland, Washington);  Adam L. Hollerbach (Richland, Washington);  Ailin Li (Richland, Washington)
ABSTRACT An apparatus includes multiple levels of ion transport channels, with successive levels coupled by elevator channels. Efficient three dimensional packing provides long path lengths in practical volumes for ion mobility separation with high resolving power. Disclosed elevator configurations provide efficient routing of ion transport channels across levels with low ion loss, enabling ion mobility separation over 100 levels or more. Elevator configurations include (i) opposed traveling waves meeting at an elevator entrance, (ii) external elevator with a wrap-around electrode bank, (iii) external elevator with electrode banks on parallel extension plates, or (iv) elevator operating in surfing mode, in various combinations. Manufacture is aided by printed wiring boards, with interchangeable boards. Assembly with motherboard, spacer block(s), and alignment pins provides efficient distribution of electrode excitations and accurate reproducible positioning.
FILED Wednesday, August 11, 2021
APPL NO 17/399629
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/68 (20130101)
G01N 27/622 (20130101) Original (OR) Class

Electric Discharge Tubes or Discharge Lamps
H01J 49/061 (20130101)
H01J 49/062 (20130101)
H01J 49/4225 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065829 Hazen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Cleveland Clinic Foundation (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Stanley L. Hazen (Pepper Pike, Ohio);  Zeneng Wang (Shaker Heights, Ohio);  Bruce S. Levison (Twinsburg, Ohio)
ABSTRACT The present invention provides markers and methods for determining whether a subject, particularly a human subject, has or is at risk of developing, a disease such as cardiovascular disease, diabetes mellitus, insulin resistance, metabolic syndrome, NAFLD (Nonalcoholic Fatty Liver Disease) or NASH (Nonalcoholic Steatohepatitis) (e.g., within the ensuing year, two years, and/or three years). The present application also relates to the use of such markers and methods for monitoring the status of such diseases in a subject or the effects of therapeutic agents on subjects with such diseases.
FILED Monday, April 19, 2021
APPL NO 17/234229
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/43 (20130101)
A61K 31/496 (20130101)
A61K 31/4164 (20130101)
A61K 31/7036 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/18 (20130101)
C12Q 1/025 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 30/88 (20130101) Original (OR) Class
G01N 30/7233 (20130101)
G01N 33/6893 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065857 Eshleman et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltmore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Susan H. Eshleman (Lutherville, Maryland);  Oliver Laeyendecker (Baltimore, Maryland);  Harry B. Larman (Baltimore, Maryland);  Kai Kammers (Baltimore, Maryland)
ABSTRACT Described are methods for estimating the cross-sectional incidence or duration of infection of a virus. Method steps include obtaining a biological sample with antibodies from a subject having a viral infection. The biological sample is mixed with two or more epitopes or peptides from the proteins of a vims responsible for the viral infection. The amount of antibody binding to the epitopes or peptides is quantified and the cross-sectional incidence or duration of infection of a virus is estimated.
FILED Monday, December 09, 2019
APPL NO 17/312916
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56988 (20130101) Original (OR) Class
G01N 2333/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065863 Dritschilo et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Georgetown University (Washington, District of Columbia)
ASSIGNEE(S) Georgetown University (Washington, District of Columbia)
INVENTOR(S) Anatoly Dritschilo (Bethesda, Maryland);  Amrita K. Cheema (Potomac, Maryland);  Scott Grindrod (Falls Church, Virginia);  Xiaogang Zhong (Greenbelt, Maryland)
ABSTRACT Methods of treating with radiation therapy a subject having cancer, in which the method comprises administering radiation therapy to the subject. The subject does not have an increased risk of having an adverse reaction to radiation therapy. The subject has an increased risk of an adverse reaction to radiation therapy when the subject's level of each component in a component profile from a sample of the subject is altered as compared to the normal level of each component. The component profile may comprise a metabolite panel of geranyl pyrophosphate, glucose-1-phosphate, and 3-hydroxy-3-methylglutaryl-CoA; a lipid panel of LPA 18:0, LPA 16:0, LPC 20:2, CER 24:0, and LPI 16:1; or a combination of these panels. The component profile may also comprise a metabolite panel of metanephrine, tryptophan, xanthurenic acid, and pantothenate; a lipid panel of LPA 18:0, DAG 16:0/18:0, LPA 16:0, and DAG 18:1/18:1; or a combination of these panels.
FILED Wednesday, September 15, 2021
APPL NO 17/476148
CURRENT CPC
Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/10 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57484 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065867 Tarca et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) Wayne State University (Detroit, Michigan);  The United States of America, as Represented by the Secretary, Department of Health and Human Service (Bethesda, Maryland)
ASSIGNEE(S) Wayne State University (Detroit, Michigan);  The United States of America, as Represented by the Secretary, Department of Health and Human Service (Bethesda, Maryland)
INVENTOR(S) Adi L. Tarca (South Lyon, Michigan);  Piya Chaemsaithong (Shatin, China Hong Kong);  Tinnakorn Chaiworapongsa (Grosse Pointe Park, Michigan);  Sonia S. Hassan (Novi, Michigan);  Roberto Romero (Grosse Pointe, Michigan)
ABSTRACT Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.
FILED Friday, November 12, 2021
APPL NO 17/525717
CURRENT CPC
Enzymes
C12Y 101/01205 (20130101)
C12Y 504/02 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/543 (20130101)
G01N 33/689 (20130101) Original (OR) Class
G01N 2333/4727 (20130101)
G01N 2800/368 (20130101)

Electric Digital Data Processing
G06F 17/18 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 5/00 (20190201)
G16B 5/20 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065870 Horton et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S) Shriners Hospitals for Children (Tampa, Florida)
ASSIGNEE(S)
INVENTOR(S) William A. Horton (Portland, Oregon);  Gregory P. Lunstrum (Portland, Oregon);  Ryan F. Coghlan (Portland, Oregon);  Jon A. Oberdorf (Warren, Oregon)
ABSTRACT The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.
FILED Thursday, November 11, 2021
APPL NO 17/524166
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Peptides
C07K 14/78 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/535 (20130101)
G01N 33/566 (20130101)
G01N 33/5029 (20130101)
G01N 33/5044 (20130101)
G01N 33/5082 (20130101)
G01N 33/6887 (20130101) Original (OR) Class
G01N 33/54306 (20130101)
G01N 33/57488 (20130101)
G01N 2800/10 (20130101)
G01N 2800/52 (20130101)
G01N 2800/60 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065874 Oh et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Center for Research Resources (NCRR)
National Institute on Aging (NIA)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland);  WAKE FOREST UNIVERSITY (Winston-Salem, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Esther Oh (Baltimore, Maryland);  Constantine Lyketsos (Baltimore, Maryland);  Suzanne Craft (Winston-Salem, North Carolina)
ABSTRACT Described herein are methods of identifying a mammal having a neurological disease or disorder, such as AD or MCI, or at risk for developing a neurological disease or disorder, such as AD or MCI. Provided herein are also methods of monitoring the progression of a neurological disease or disorder in a patient or monitoring the effectiveness of therapeutic agent or treatment of a patient having a neurological disease or disorder.
FILED Tuesday, September 08, 2020
APPL NO 17/013974
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/488 (20130101)

Peptides
C07K 16/18 (20130101)
C07K 2317/76 (20130101)

Enzymes
C12Y 304/23046 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/48 (20130101)
G01N 33/66 (20130101)
G01N 33/6896 (20130101) Original (OR) Class
G01N 2333/62 (20130101)
G01N 2333/605 (20130101)
G01N 2333/4709 (20130101)
G01N 2800/50 (20130101)
G01N 2800/52 (20130101)
G01N 2800/2814 (20130101)
G01N 2800/2821 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065962 ZHOU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Research Resources (NCRR)
APPLICANT(S) The Board of Trustees of the University of llinois (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S) Xiaohong Joe ZHOU (Chicago, Illinois);  Zheng ZHONG (Chicago, Illinois);  Meryem Muge KARAMAN (Chicago, Illinois)
ABSTRACT A system and method for producing a series of time-resolved magnetic resonance (MR) images is set forth. The system can perform method steps of encoding spatial information into an MRI signal by manipulating a phase of the MRI signal within an MRI system, generating and outputting a phase-encoded MRI signal over time by digitizing a plurality of time points in the MRI signal, repeating the generating and outputting step for a plurality of phase-encoded signals, each phase-encoded signal in synchrony with a trigger, producing a plurality of digitized time points, and reconstructing a series of time resolved MR images, each image of the series of MR images at one specific time point selected from the plurality of digitized time points for each phase-encoded step. Each image in the series of time-resolved MR images corresponding to a specific time point in a cyclic event.
FILED Tuesday, January 21, 2020
APPL NO 17/423729
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/4824 (20130101) Original (OR) Class
G01R 33/5608 (20130101)
G01R 33/5611 (20130101)
G01R 33/5616 (20130101)
G01R 33/5673 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220066027 Pang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) FUJIFILM SONOSITE, INC. (Bothell, Washington)
ASSIGNEE(S) FUJIFILM SONOSITE, INC. (Bothell, Washington)
INVENTOR(S) Guofeng Pang (Ajax, Canada);  Oleg Ivanytskyy (Toronto, Canada);  Hossein Amini (Toronto, Canada);  Robert Kolaja (Toronto, Canada)
ABSTRACT A dual frequency ultrasound transducer includes a high frequency (HF) transducer and a low frequency (LF) transducer that is positioned behind the high frequency transducer. An intermediate layer is positioned between the low frequency transducer and the high frequency transducer to absorb high frequency ultrasound signals. An alignment feature on the low frequency transducer is positioned with respect to a fiducial that is marked at a known position with respect to high frequency transducer elements of the HF transducer to align low frequency transducer elements of the LF transducer with the HF transducer elements.
FILED Tuesday, November 09, 2021
APPL NO 17/522293
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 15/8915 (20130101)
G01S 15/8952 (20130101) Original (OR) Class
G01S 15/8956 (20130101)
G01S 15/8979 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220066186 Kang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
Fogarty International Center (FIC)
APPLICANT(S) Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S) Dongkyun Kang (Tucson, Arizona);  Cheng Gong (Tucson, Arizona)
ABSTRACT Devices, systems and methods are described that can be used to develop confocal microscopes with high lateral resolution. One example confocal microscope includes a first dispersion element that receives a light beam and to produce illumination beams with different spectral components, and an objective that receives reflected light upon reflection of the illumination beams from a target. The confocal microscope further includes a second dispersion element that receives the reflected light after propagation through in the objective lens, and a third dispersion element that receives the dispersed light associated with the second dispersion element and provides an output light to a camera lens for focusing onto a detector. The second and the third dispersion elements are positioned such that each point on the detector is conjugate to a corresponding single point on the target. Some applications of the disclosed confocal microscopes include skin disease diagnosis and imaging of freshly-excised tissues.
FILED Friday, January 17, 2020
APPL NO 17/419921
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 3/28 (20130101)

Optical Elements, Systems, or Apparatus
G02B 21/02 (20130101)
G02B 21/0032 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067105 Vodovotz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Yoram Vodovotz (Sewickley, Pennsylvania);  Fayten El-Dehaibi (Pittsburgh, Pennsylvania);  Qi Mi (Pittsburgh, Pennsylvania)
ABSTRACT This document describes a search engine that accepts as input different types of data files and conditions for search parameters, including both single and multiple time points, concatenates these data, and outputs data from the different types of files that satisfies the specified search conditions. In one aspect, a method includes receiving a selection of a multiple input data files that each include data on which a search is to be performed. The input data files include different types of data files having different data formats. An in-memory data structure that includes the data of the input data files arranged in a common format is generated. For each of one or more search parameters, data indicating a condition for the search parameter is received. A set of data that satisfies the condition of each of the one or more search parameters is identified in the in-memory data structure.
FILED Wednesday, August 26, 2020
APPL NO 17/003661
CURRENT CPC
Electric Digital Data Processing
G06F 16/90344 (20190101) Original (OR) Class

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/20 (20190201)
G16B 50/30 (20190201)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/60 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067442 Masse et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Institute of Mental Health (NIMH)
National Science Foundation (NSF)
Directorate for Social, Behavioral and Economic Sciences (SBE)
Division of Behavioral and Cognitive Sciences (BCS)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S) The University of Chicago (Chicago, Illinois)
INVENTOR(S) Nicolas Y. Masse (Chicago, Illinois);  Gregory D. Grant (Chicago, Illinois);  David J. Freedman (Chicago, Illinois)
ABSTRACT A computing device may receive a first set of training data for training an ANN to predict output data for a first task, and may train the ANN with the first set of training data by only adjusting values of weights associated with a first subset of neurons, the first subset selected based on an identity of the first task. The computing device may receive a second, different set of training data for training the ANN to predict output data for a second task, and may train the ANN with the second set of training data by only adjusting values of weights associated with a second subset of neurons, the second subset selected based on an identity of the second task. During training, adjusting of the value of any weight may entail weight stabilization that depends on whether there has been any training for one or more previous tasks.
FILED Thursday, November 11, 2021
APPL NO 17/524338
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6228 (20130101)
G06K 9/6257 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067933 Alizad et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Azra Alizad (Rochester, Minnesota);  Mostafa Fatemi (Rochester, Minnesota);  Redouane Ternifi (Rochester, Minnesota);  Yinong Wang (Rochester, Minnesota)
ABSTRACT The present disclosure addresses a quantitative analysis of tumor vascularity patterns, with the goal of identifying biomarkers correlated with malignancy. Herein, we identify new types of quantitative ultrasound biomarkers of microvessel morphology that correlate with the state of the disease in question. We propose a novel method to automatically extract quantitative features related to the morphology and distribution of the vascular networks reconstructed from contrast-free ultrasound data. For instance, spatial vascularity pattern, bifurcation angle, Murray's deviation, fractal dimension and closet vessel distance were clearly depicted.
FILED Friday, September 03, 2021
APPL NO 17/466773
CURRENT CPC
Image Data Processing or Generation, in General
G06T 7/0012 (20130101) Original (OR) Class
G06T 7/73 (20170101)
G06T 7/155 (20170101)
G06T 2207/10132 (20130101)
G06T 2207/20024 (20130101)
G06T 2207/30068 (20130101)
G06T 2207/30096 (20130101)
G06T 2207/30101 (20130101)
G06T 2207/30172 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 50/20 (20180101)
G16H 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068432 Ruderfer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Douglas Ruderfer (Nashville, Tennessee);  Theodore Morley (Nashville, Tennessee)
ABSTRACT Systems and methods of evaluating electronic health record data to identify genetic disorders. Electronic health record (EHR) data for a patient is accessed from a non-transitory computer-readable memory and an input data set is generated indicative of one or more phenotypes indicated by the EHR data. A trained artificial intelligence model is then applied to the input data set and produces an output indicating whether the patient is a candidate for genetic testing based on the one or more phenotypes indicated by the electronic health record data. An output signal is then transmitted in response to determining that the patient is a candidate for the genetic testing. In some implementations, a computer-based system is configured to automatically schedule the patient for a genetic testing procedure and/or to notify a medical care provider that the patient is a candidate for genetic testing in response to the output signal.
FILED Friday, August 27, 2021
APPL NO 17/459652
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/00 (20190201) Original (OR) Class
G16B 20/10 (20190201)
G16B 20/20 (20190201)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/40 (20180101)
G16H 10/60 (20180101)
G16H 40/20 (20180101)
G16H 50/20 (20180101)
G16H 50/30 (20180101)
G16H 70/60 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068438 Regev et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Aviv Regev (Cambridge, Massachusetts);  Tommaso Biancalani (Cambridge, Massachusetts);  Gabriele Scalia (Cambridge, Massachusetts);  Lorenzo Buffoni (Cambridge, Massachusetts)
ABSTRACT The present invention provides for methods, systems and computer products for aligning single cell data with spatial data to generate spatial maps of cell types and gene expression at single cell resolution. The invention further provides for mapping to common coordinate frameworks.
FILED Friday, August 27, 2021
APPL NO 17/459368
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 3/088 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 40/30 (20190201) Original (OR) Class
G16B 45/00 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068501 Gholami et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
APPLICANT(S) Autonomous Healthcare, Inc. (Hoboken, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Behnood Gholami (Hoboken, New Jersey);  Amir Avnit (New Haven, Connecticut);  Deepak Khemraj (South Ozone Park, New York)
ABSTRACT The present disclosure describes a system, apparatus, and method involving immutable databases such as blockchains to track and document transportation and administration of sensitive medications and identify potential cases of drug diversion. The disclosed invention uses a transaction recording module to scan unique tags for sensitive medications packs during the transport process. The invention also comprises an image and video capture module, an immutable database, a computation engine, a graphical user interface, and a notification module.
FILED Wednesday, September 01, 2021
APPL NO 17/463851
CURRENT CPC
Electric Digital Data Processing
G06F 21/32 (20130101)

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 20/10 (20180101)
G16H 70/40 (20180101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 20220062012 Altobelli et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Research, Development and Engineering Command (RDECOM)
APPLICANT(S) DEKA Products Limited Partnership (Manchester, New Hampshire)
ASSIGNEE(S)
INVENTOR(S) David E. Altobelli (Hollis, New Hampshire);  N. Christopher Perry (Manchester, New Hampshire)
ABSTRACT A dynamic support apparatus having a frame, a dynamic interface, a temperature control mechanism, and a control system. The dynamic interface is capable of changing its geometry and is disposed on the top surface of the frame. The control system is operably connected to the dynamic interface and controls the changing geometry of the dynamic interface. There is also a temperature control mechanism disposed on the top surface of the frame for maintaining a comfortable temperature and moisture environment between the apparatus and the user's body.
FILED Monday, November 15, 2021
APPL NO 17/526101
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/7843 (20130101) Original (OR) Class
A61F 5/012 (20130101)
A61F 2002/5012 (20130101)

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 33/3842 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062379 WARREN et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Luis BARREIRO (Montreal, Canada);  The General Hospital Corporation (Boston, Massachusetts);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Howland Shaw WARREN (Boston, Massachusetts);  David GREGORY (Boston, Massachusetts);  Wenzhong XIAO (Boston, California);  Feifei HAN (Boston, Massachusetts);  Luis BARREIRO (Montreal, Canada);  Judith HELLMAN (Oakland, California)
ABSTRACT The invention relates to a method for treating a disease of immune dysregulation or altering an immune response or both in a mammal Such methods include administering to the mammal a therapeutically effective amount of a modulating agent or subjecting the mammal to a modulating process, wherein the modulating agent or process alters the expression or activity of a gene target associated with a sensitive response or a resistant response to an inflammatory stimulus.
FILED Friday, January 17, 2020
APPL NO 17/423244
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/403 (20130101)
A61K 31/4965 (20130101)
A61K 31/4985 (20130101)
A61K 38/1709 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6883 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6893 (20130101)
G01N 2800/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062396 COOPER et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Laurence JN COOPER (Houston, Texas);  Hiroki TORIKAI (Houston, Texas);  Ling ZHANG (Houston, Texas);  Helen HULS (Houston, Texas);  Feng WANG-JOHANNING (Bastrop, Texas);  Lenka HURTON (Houston, Texas);  Simon OLIVARES (Houston, Texas);  Janani KRISHNAMURTHY (Houston, Texas)
ABSTRACT The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.
FILED Tuesday, April 06, 2021
APPL NO 17/223597
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101)
A61K 39/0011 (20130101) Original (OR) Class
A61K 39/00111 (20180801)
A61K 39/00117 (20180801)
A61K 39/00119 (20180801)
A61K 39/001104 (20180801)
A61K 39/001106 (20180801)
A61K 39/001109 (20180801)
A61K 39/001112 (20180801)
A61K 39/001113 (20180801)
A61K 39/001119 (20180801)
A61K 39/001124 (20180801)
A61K 39/001129 (20180801)
A61K 39/001151 (20180801)
A61K 39/001164 (20180801)
A61K 39/001168 (20180801)
A61K 39/001171 (20180801)
A61K 39/001174 (20180801)
A61K 39/001181 (20180801)
A61K 39/001182 (20180801)
A61K 39/001194 (20180801)
A61K 2039/505 (20130101)
A61K 2039/5158 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 37/00 (20180101)

Peptides
C07K 14/5443 (20130101)
C07K 14/7051 (20130101)
C07K 14/70521 (20130101)
C07K 16/30 (20130101)
C07K 2317/622 (20130101)
C07K 2319/02 (20130101)
C07K 2319/03 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062401 Jin et al.
FUNDED BY
Department of Defense (DOD)
Defense Threat Reduction Agency (DTRA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Rongsheng Jin (Irvine, California);  Philip Felgner (Irvine, California);  Peng Chen (Irvine, California)
ABSTRACT Methods and compositions for treating or preventing C. difficile infection (CDI) through TcdB or TcdA holotoxins. The compositions feature immunogens or binding agents, such as antibodies, nanobodies (VHHs), single-domain antibodies (sdAbs), etc., based on one or a combination of neutralizing epitopes of TcdB or TcdA. Where immunogens inhibit the conformational changes necessary for pore formation by TcdB at an endosomal pH. Additionally, immunogens inhibit the movement of the scissile bond into the CPD cleavage side and a proper orientation of GTD relative to CPD, thus inhibiting cleavage of the GTD, which is required to activate the toxin. The present invention also describes vaccines for treatment of CDI, e.g., vaccines that target TcdB or TcdA.
FILED Friday, November 19, 2021
APPL NO 17/531058
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/08 (20130101) Original (OR) Class

Peptides
C07K 14/33 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062404 GARRISON et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Development Command (USAMRDC)
Medical Research Institute of Infectious Diseases (USAMRIID)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Aura Rae GARRISON (Knoxville, Maryland);  Charles Jason SHOEMAKER (Stephens City, Virginia);  Joseph Walter GOLDEN (Hagerstown, Maryland)
ASSIGNEE(S)
INVENTOR(S) Aura Rae GARRISON (Knoxville, Maryland);  Charles Jason SHOEMAKER (Stephens City, Virginia);  Joseph Walter GOLDEN (Hagerstown, Maryland)
ABSTRACT Crimean-Congo hemorrhagic fever virus (CCHFV) is an important human pathogen. Limited evidence suggests that antibodies can protect humans against lethal CCHFV disease, but the protective efficacy of antibodies has never been evaluated in adult animal models. Here adult mice were used to investigate the protection provided by glycoprotein-targeting neutralizing and non-neutralizing monoclonal antibodies (mAbs) against CCHFV infection. A single non-neutralizing antibody (mAb-13G8) was identified that protected adult type I interferon deficient mice >90% when treatment was initiated prior to virus exposure and >60% when administered after virus exposure. Neutralizing antibodies known to protect neonatal mice from lethal CCHFV infection, failed to confer protection regardless of IgG subclass. The target of mAb-13G8 was identified as GP38, one of multiple proteolytically-cleaved glycoproteins derived from the CCHFV glycoprotein precursor polyprotein. Robust protection required complement activity, but not Fc-receptor functionality. Consistently, it was found that GP38 previously identified as a secreted molecule also localizes to viral envelope and cellular plasma membranes. This study reveals GP38 as an important antibody target for CCHFV and lays the foundation to develop novel vaccines and immunotherapeutic against CCHFV in human.
FILED Tuesday, January 07, 2020
APPL NO 17/418357
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 16/10 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062501 Galiano et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Development Command (USAMRDC)
Armed Forces Institute of Regenerative Medicine (AFIRM)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Robert D. Galiano (Glenview, Illinois);  Seok Jong Hong (Northbrook, Illinois);  Thomas A. Mustoe (Evanston, Illinois)
ABSTRACT The present invention provides methods of regenerating muscle tissue and methods of treating volumetric muscle loss comprising administering decellularized fetal matrix scaffold. Also provided are methods for treating soft tissue injury and improving reconstructive surgery.
FILED Tuesday, July 27, 2021
APPL NO 17/443590
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/367 (20130101)
A61L 27/3604 (20130101) Original (OR) Class
A61L 27/3687 (20130101)
A61L 27/3826 (20130101)
A61L 27/3873 (20130101)
A61L 2430/04 (20130101)
A61L 2430/30 (20130101)
A61L 2430/40 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062948 Glavin et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S) Nicholas R. Glavin (Springboro, Ohio);  Christopher Muratore (Kettering, Ohio);  Melani K. Muratore (Kettering, Ohio)
ABSTRACT A process of making sensors and sensor arrays that provided real time notification of any centerline deviation. Such production process can be adjusted in real time. Thus, large numbers of units can be made—even in millions of per day—with few if any out of specification units being produced. Such process does not require large-scale clean rooms and is easily configurable.
FILED Wednesday, November 10, 2021
APPL NO 17/523721
CURRENT CPC
Processes for Applying Fluent Materials to Surfaces, in General
B05D 1/28 (20130101) Original (OR) Class
B05D 3/06 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 29/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220063110 KONG et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Development Command (USAMRDC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) The Board of Trustees of the University of Illinois (Urbana, Illinois);  Purdue Research Foundation (, None)
ASSIGNEE(S)
INVENTOR(S) Hyunjoon KONG (Urbana, Illinois);  Byoungsoo KIM (Urbana, Illinois);  Jonghwi LEE (Urbana, Illinois);  Chi Hwan LEE (West Lafayette, Indiana);  Min Ku KIM (Lafayette, Indiana)
ABSTRACT Provided herein are manipulators for handling fragile layers and related methods of handling using the manipulators. The manipulators comprise a contact surface with thermally responsive recess features and a microelectric heater in thermal contact with the contact surface. In this manner, the manipulator is an electrothermal manipulator, with changes in temperature providing a contact force to pick-up a transferable layer material and a release force to facilitate release of the transferable from the manipulator.
FILED Tuesday, August 31, 2021
APPL NO 17/462862
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 7/00 (20130101)
B25J 11/0095 (20130101)
B25J 15/008 (20130101) Original (OR) Class
B25J 19/0025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220063183 Simpson et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) NDSU RESEARCH FOUNDATION (Fargo, North Dakota)
ASSIGNEE(S)
INVENTOR(S) Patrick Simpson (Fargo, North Dakota);  Michael Holthaus (Fargo, North Dakota);  Chad Ulven (Fargo, North Dakota)
ABSTRACT Suspending fibers within a substantially similar direction within flow field allows for an even dispersion of fibers in a manufactured composite. The flow field can be established within a resin tank so as to control orientation of the fibers. An advantage of this approach is that fiber orientation can be changed layer by layer during printing. No matter where the reinforcements need to be, the fibers can be aligned on the fly to accommodate. 3D prints can made stronger for a very wide range of objects and opportunities.
FILED Thursday, July 01, 2021
APPL NO 17/305224
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801) Original (OR) Class
B29C 64/321 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 70/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220063986 Suresh et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Nanyang Technological University (Singapore, Singapore)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Nanyang Technological University (Singapore, Singapore)
INVENTOR(S) Subra Suresh (Singapore, Singapore);  Ming Dao (West Roxbury, Massachusetts);  Ju Li (Weston, Massachusetts);  Zhe Shi (Cambridge, Massachusetts)
ABSTRACT Compositions and methods related to multiaxially straining defect doped materials as well as their use in electrical circuits are generally described.
FILED Wednesday, August 25, 2021
APPL NO 17/411707
CURRENT CPC
Microstructural Devices or Systems, e.g Micromechanical Devices
B81B 3/0062 (20130101) Original (OR) Class
B81B 2201/018 (20130101)
B81B 2203/051 (20130101)
B81B 2203/053 (20130101)
B81B 2203/056 (20130101)
B81B 2203/0118 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064666 Ma et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S)
INVENTOR(S) Yitong Ma (Pasadena, California);  Mark W. Budde (Pasadena, California);  Michaelle N. Mayalu (Pasadena, California);  Michael B. Elowitz (Pasadena, California)
ABSTRACT Disclosed herein include circuits, compositions, nucleic acids, populations, systems, and methods enabling cells to sense, control, and/or respond to their own population size. In some embodiments, an orthogonal communication channel allows specific communication between engineered cells. Also described herein, in some embodiments, is an evolutionarily robust ‘paradoxical’ regulatory circuit architecture in which orthogonal signals both stimulate and inhibit net cell growth at different signal concentrations. In some embodiments, engineered cells autonomously reach designed densities and/or activate therapeutic or safety programs at specific density thresholds. Methods of treatment are also provided in some embodiments.
FILED Friday, August 27, 2021
APPL NO 17/460120
CURRENT CPC
Peptides
C07K 14/415 (20130101)
C07K 2319/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0069 (20130101)
C12N 9/86 (20130101)
C12N 15/11 (20130101)
C12N 15/85 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
C12N 2800/107 (20130101)
C12N 2810/10 (20130101)

Enzymes
C12Y 113/12003 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064699 Xuan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Feng Xuan (Cambridge, Massachusetts);  Peng Yin (Cambrige, Massachusetts);  Mingjie Dai (Cambrige, Massachusetts);  Xi Chen (Cambridge, Massachusetts)
ABSTRACT The present disclosure provides, in some embodiments, methods and compositions for single-molecule detection.
FILED Wednesday, November 10, 2021
APPL NO 17/523611
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6804 (20130101) Original (OR) Class

Combinatorial Chemistry; Libraries, e.g Chemical Libraries
C40B 70/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065739 Giurgiutiu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) University of South Carolina (Columbia, South Carolina)
ASSIGNEE(S) University of South Carolina (Columbia, South Carolina)
INVENTOR(S) Victor Giurgiutiu (Columbia, South Carolina);  Yeasin Bhuiyan (Vergennes, Vermont);  Matthew Droghini (Aiken, South Carolina)
ABSTRACT A new vibration test-cell that allows a static load to be applied simultaneously with lateral vibration coupled with in-situ microscopy that allows for the ability to open a fatigue crack up to a desired gap, as well as generate acoustic emission (AE) from vibration excitation, micro-fracture events are captured by the AE measurement while the physical observation of the crack faying surfaces is performed in-situ with an optical microscope embedded in the test cell.
FILED Thursday, September 03, 2020
APPL NO 17/010988
CURRENT CPC
Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for
G01M 7/022 (20130101)
G01M 7/025 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 3/32 (20130101)
G01N 2203/0067 (20130101)
G01N 2203/0658 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065793 Postelnicu et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E)
MIT Lincoln Laboratory (MITLL)
Federally Funded Research and Development Center (FFRDC)
Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Eveline Postelnicu (Somerville, Massachusetts);  Samarth Aggarwal (Ghaziabad, India);  Kazumi WADA (Lexington, Massachusetts);  Jurgen MICHEL (Arlington, Massachusetts);  Lionel C. KIMERLING (Concord, Massachusetts);  Michelle L. Clark (Pelham, New Hampshire);  Anuradha M. AGARWAL (Weston, Massachusetts)
ABSTRACT A layer of amorphous Ge is formed on a substrate using electron-beam evaporation. The evaporation is performed at room temperature. The layer of amorphous Ge has a thickness of at least 50 nm and a purity of at least 90% Ge. The substrate is complementary metal-oxide-semiconductor (CMOS) compatible and is transparent at Long-Wave Infrared (LWIR) wavelengths. The layer of amorphous Ge can be used as a waveguide in chemical sensing and data communication applications. The amorphous Ge waveguide has a transmission loss in the LWIR of 11 dB/cm or less at 8 μm.
FILED Tuesday, November 09, 2021
APPL NO 17/522819
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/7746 (20130101) Original (OR) Class

Optical Elements, Systems, or Apparatus
G02B 6/125 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 2021/60165 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065912 KELLER, III et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Sea Systems Command (NAVSEA)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) NOKOMIS, INC (Charleroi, Pennsylvania)
ASSIGNEE(S) NOKOMIS, INC (Charleroi, Pennsylvania)
INVENTOR(S) Walter John KELLER, III (Bridgeville, Pennsylvania);  Andrew Richard PORTUNE (Oakdale, Pennsylvania);  Todd Eric CHORNENKY (Carmichaels, Pennsylvania);  William Anthony DAVIS (Perrysburg, Ohio)
ABSTRACT An apparatus for detecting a condition or authenticity of one or more electronic devices includes an enclosure having an antenna integrated therewithin, a fixture mounted within a hollow interior of the enclosure, the fixture being configured to receive the one or more electronic devices and connect one or more signals to each of the one or more electronic devices and a sensor and controller assembly connected to the antenna and configured to process a signature of an emission of a radiofrequency (RF) energy from of one or more electronic devices having the one or more signals connected thereto.
FILED Monday, April 26, 2021
APPL NO 17/240081
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/002 (20130101) Original (OR) Class

Electric Digital Data Processing
G06F 21/73 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 2924/0002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065926 Chakrabarty et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Krishnendu Chakrabarty (Durham, North Carolina);  Arjun Chaudhuri (Durham, North Carolina)
ABSTRACT A method for identifying observation points for integrated circuit (IC) testing includes receiving a netlist for an IC that includes a first subcircuit and a second subcircuit; determining, from the netlist, one or more observation points, each determined observation point corresponding to an output node which provides observability, into at least the first subcircuit, of an effective number of gates above a specified threshold; and inserting a design for test element into a layout file of the IC at each determined observation point. Observation points can be determined by transforming the netlist into a node graph; assigning a same initial value to a value field of each node; and propagating values in the value fields of the nodes until all nodes with a succeeding edge have a value of zero in their value fields.
FILED Tuesday, August 24, 2021
APPL NO 17/410654
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/3177 (20130101) Original (OR) Class

Electric Digital Data Processing
G06F 30/327 (20200101)
G06F 30/392 (20200101)
G06F 2119/02 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220066082 YOUNG et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S) Steve YOUNG (Ann Arbor, Michigan);  Anthony GRBIC (Ann Arbor, Michigan);  Moshen JAFARI (Ann Arbor, Michigan)
ABSTRACT Transmissive and reflective all-dielectric metastructures are presented that offer tailored polarization conversions and spectral responses. The metastructures consist of stacked deeply subwavelength, high contrast gratings of different fill factors and rotations. Broadband metastructures that perform a given polarization conversion over a wide continuous bandwidth will be shown, as well as multiband metastructures that perform a common polarization conversion over different bands. Unlike conventional stacked grating geometries, the transmissive metastructures do not require antireflection layers since impedance matching is incorporated into their design. The subwavelength gratings are modeled as homogeneous anisotropic layers, allowing an overall metastructure to be treated as a stratified dielectric medium. Quasi-static analysis is used to homogenize the subwavelength gratings and represent them with effective dielectric constants. Plane-wave transfer matrix techniques are employed to model the interactions between gratings, allowing for rapid design and optimization.
FILED Thursday, September 02, 2021
APPL NO 17/464825
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 5/3041 (20130101) Original (OR) Class
G02B 5/3083 (20130101)
G02B 27/281 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220066189 Yakovlev
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) The Texas A and M University System (College Station, Texas)
ASSIGNEE(S)
INVENTOR(S) Vladislav V. Yakovlev (College Station, Texas)
ABSTRACT A spectroscopy device includes an incoherent light source, tunable to a predetermined emission wavelength; a microscope platform comprising a microscope objective comprising a deep-UV optimized objective and a focal plane defined thereon; a notch filter having an absorption frequency matched to the emission wavelength; and a frequency-selective optical path from the wide-field UV light source to the microscope platform onto the focal plane and from the focal plane through the notch filter.
FILED Friday, May 21, 2021
APPL NO 17/326576
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 3/2823 (20130101)

Optical Elements, Systems, or Apparatus
G02B 21/08 (20130101)
G02B 21/16 (20130101) Original (OR) Class
G02B 21/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220066279 Spence et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Scott E. Spence (Fredericksburg, Virginia);  Allen D. Parks (Spotsylvania, Virginia)
ASSIGNEE(S) United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S) Scott E. Spence (Fredericksburg, Virginia);  Allen D. Parks (Spotsylvania, Virginia)
ABSTRACT A Mach-Zehnder interferometer (MZI) is provided to receive a coherent input photon in an initial pointer state along an emission direction for producing a continuous variable “faux qubit” in a magic state. The MZI apparatus includes first and second ports, first and second beam-splitters, first and second mirrors, and a modular interaction operator. The emitter produces an input coherent photon in an initial pointer state along an emission direction. The first and second ports are respectively disposed parallel and perpendicular to the emission direction. The first port has a detector. The first beam-splitter is disposed collinearly with the emission direction. The second beam-splitter is disposed between the first and second ports in parallel to and offset from the emission direction. The input photon reflects from the mirrors. Each beam-splitter either passes through or else reflects the input photon. The first mirror is disposed from the first and second beam-splitters respectively perpendicular and parallel to the emission direction. The second mirror is disposed from the first and second beam-splitters respectively collinearly with and perpendicular to the emission direction. The modular interaction operator is disposed between the first mirror and the second beam-splitter for measuring interaction therebetween to thereby generate a post-selected magic state photon. Further embodiments include an actuator that translates the first mirror diagonally to and from the beam-splitters to set coupling strength. Additional embodiments enable a phase angle shift between the first beam-splitter and the first mirror.
FILED Tuesday, September 01, 2020
APPL NO 17/008812
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 9/02 (20130101)

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/225 (20130101) Original (OR) Class
G02F 2001/212 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220066513 Mooney et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) Dephy, Inc. (Maynard, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Luke Mooney (Sudbury, Massachusetts);  Jonathan Cummings (Concord, Massachusetts);  Jean-François Duval (Belmont, Massachusetts)
ABSTRACT An apparatus for a water resistant active exoskeleton boot includes a shin pad and one or more housings. The one or more housings enclose electronic circuitry and an electric motor that generate torque about an axis of rotation of an ankle joint of the user. A sealant is placed in contact with the one or more housings to close the one or more housings and prevent an ingress of water into the one or more housings. The apparatus includes an output shaft coupled to the electric motor and extending through a bore in a housing of the one or more housings enclosing the electric motor. The apparatus includes a seal to prevent an ingress of the water into the one or more housings. The apparatus includes a rotary encoder enclosed within the one or more housings to measure an angle of the electric motor.
FILED Tuesday, August 25, 2020
APPL NO 17/002556
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 9/0006 (20130101)

Electric Digital Data Processing
G06F 1/1656 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220066869 Hornung et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Bryan Hornung (Plano, Texas);  David Patrick (McKinney, Texas)
ABSTRACT Systems, apparatuses, and methods related to chiplets are described. A chiplet-based system may include a memory controller chiplet to control accesses to a storage array, and the memory controller chiplet can facilitate error correction and cache management in a manner to minimize interruptions to a sequence of data reads to write corrected data from a prior read back into the storage array. For example, a read command may be received at a memory controller device of the memory system from a requesting device. Data responsive to the read command may be obtained and determined to include a correctable error. The data may be corrected, transmitted to the requesting device and written to cache of the memory controller device with an indication that data is valid and dirty (e.g., includes an error or corrected error). The data is written back to the memory array in response to a cache eviction event.
FILED Monday, August 31, 2020
APPL NO 17/007811
CURRENT CPC
Electric Digital Data Processing
G06F 11/106 (20130101)
G06F 11/1068 (20130101) Original (OR) Class
G06F 11/3037 (20130101)
G06F 12/0246 (20130101)
G06F 12/0891 (20130101)
G06F 13/1668 (20130101)
G06F 2212/7209 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220066967 Brewer
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Tony Brewer (Plano, Texas)
ABSTRACT Implementations of the present disclosure are directed to systems and methods for reducing design complexity and critical path timing challenges of credit return logic. A wide bus supports simultaneous transmission of multiple flits, one per lane of the wide bus. A source device transmitting flits on a wide bus selects from among multiple credit return options to ensure that only one of the multiple flits being simultaneously transmitted includes a credit return value. In some example embodiments, the receiving device checks only the flit of one lane of the wide bus (e.g., lane 0) for credit return data. In other example embodiments, the receiving device uses a bitwise-OR to combine the credit return data of all received flits in a single cycle.
FILED Monday, August 31, 2020
APPL NO 17/007814
CURRENT CPC
Electric Digital Data Processing
G06F 13/364 (20130101) Original (OR) Class
G06F 30/3953 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220066969 Patrick et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) David Patrick (McKinney, Texas);  Tony Brewer (Plano, Texas)
ABSTRACT Implementations of the present disclosure are directed to systems and methods for mapping point-to-point channels to packet virtual channels. A chip with an point-to-point interface converts point-to-point data to a packet format. The point-to-point channels are mapped to virtual channels of the packet transmission protocol. Information from multiple point-to-point channels may be combined in a single packet. Among the benefits of implementations of the present disclosure is that point-to-point devices may be connected to a packetized network without losing the benefits of separate channels for different types of communication. This allows existing point-to-point devices to communicate using a packetized network without internal modification or performance degradation.
FILED Monday, August 31, 2020
APPL NO 17/007592
CURRENT CPC
Electric Digital Data Processing
G06F 13/385 (20130101) Original (OR) Class
G06F 13/4031 (20130101)
G06F 13/4282 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 45/74 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067140 Cambou et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
APPLICANT(S) Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona)
ASSIGNEE(S)
INVENTOR(S) Bertrand F Cambou (Flagstaff, Arizona);  Mohammad Mohammadinodoushan (Flagstaff, Arizona)
ABSTRACT Systems and methods for improving security in computer-based authentication systems by using physical unclonable functions are presented. A computing device used to provide authentication includes multiple arrays of physical unclonable function devices. Rather than storing user passwords or message digests of passwords, the computing device generates a message digest based on a user's credentials. A challenge response generated by measuring physical parameters of set of physical unclonable function devices specified by the message digest. The computing device can provide authentication without storing information which could be used by an attacker to compromise user credentials. Redundancy and robustness to varying loads are provided by the use of multiple PUF arrays which may be used as backups or to provide load balancing. Backdoor access may be provided to trusted parties without exposing user credentials.
FILED Thursday, April 15, 2021
APPL NO 17/231914
CURRENT CPC
Electric Digital Data Processing
G06F 21/46 (20130101) Original (OR) Class

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/3278 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067153 Roy
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Radhika Roy (Howell, New Jersey)
ABSTRACT Various embodiments that pertain to augmented reality security. A user interface can disclose an augmented reality. The user interface and/or augmented reality can be subjected to security protections. In one example, a check can be made on if an unknown party is viewing the augmented reality. If this occurs, then a notification can be emitted announcing a potential security breach.
FILED Thursday, September 03, 2020
APPL NO 17/011243
CURRENT CPC
Electric Digital Data Processing
G06F 21/554 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Image Data Processing or Generation, in General
G06T 19/006 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067247 Suresh et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Nanyang Technological University (Singapore, Singapore)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts);  Nanyang Technological University (Singapore, Singapore)
INVENTOR(S) Subra Suresh (Singapore, Singapore);  Ming Dao (West Roxbury, Massachusetts);  Ju Li (Weston, Massachusetts);  Zhe Shi (Cambridge, Massachusetts)
ABSTRACT Methods for training statistical models for modeling phononic energy and/or frequency dispersion, as well as phononic stability of materials as a function of an applied strain, as well as uses of these trained statistical models for elastic strain engineering of materials, are described.
FILED Wednesday, August 25, 2021
APPL NO 17/411748
CURRENT CPC
Electric Digital Data Processing
G06F 30/27 (20200101) Original (OR) Class
G06F 2111/10 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067249 Steingrimsson
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S) Baldur Andrew Steingrimsson (Wilsonville, Oregon)
ASSIGNEE(S) Imagars LLC (Wilsonville, Oregon)
INVENTOR(S) Baldur Andrew Steingrimsson (Portland, Oregon)
ABSTRACT This invention presents an innovative framework for the application of machine learning (ML) for identification of energetic materials with desired properties of interest. For the output properties of interest, we identify the corresponding driving (input) factors. We present a framework for a generic engine for predicting properties of energetic materials, once capable of interacting with and receiving support from physics-based prediction models, supporting joint optimization, accounting for properties both at macro- and micro-level, supporting multi-linear regression of descriptors, and offering physics-based interpretation of the descriptors. We present an approach for formulating descriptors, capable of both capturing properties and behavior of complex molecular structures, and that can be imported into ML algorithms for analysis. We show how combustion temperature and density can be analytically accounted for in a hybrid ML and physics-based model for optimizing a specific impulse, for purpose of making the most of the usually limited input data available.
FILED Saturday, October 09, 2021
APPL NO 17/497900
CURRENT CPC
Electric Digital Data Processing
G06F 30/27 (20200101) Original (OR) Class
G06F 30/28 (20200101)
G06F 2111/04 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067250 Chakrabarty et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Krishnendu Chakrabarty (Durham, North Carolina);  Sanmitra Banerjee (Durham, North Carolina)
ABSTRACT Variation-aware delay fault testing suitable for carbon nanotube field-effect transistor circuits can be accomplished using an electronic design automation tool that performs long path selection by generating random variation scenarios, wherein a random variation scenario (RVS) is an instance of an input netlist where values for a set of process parameters for each gate are chosen from a set of values for each process parameter of the set of process parameters for that gate, the set of values being sampled from a distribution of that particular process parameter for that gate and includes a nominal value for that particular process parameter; calculating a total delay through a path for each RVS; and selecting at least two paths having highest total delays for each fault site under random variations of the RVSs. Delay test patterns can then be generated for the selected paths.
FILED Wednesday, August 25, 2021
APPL NO 17/411346
CURRENT CPC
Electric Digital Data Processing
G06F 30/31 (20200101) Original (OR) Class
G06F 30/3308 (20200101)
G06F 2117/06 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067417 Banerjee et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Srutarshi Banerjee (Chicago, Illinois);  Henry H. Chopp (Glencoe, Illinois);  Juan Gabriel Serra Pérez (Evanston, Illinois);  Zihao Wang (Evanston, Illinois);  Oliver Strider Cossairt (Evanston, Illinois);  Aggelos K. Katsaggelos (Chicago, Illinois)
ABSTRACT A system to process imaging data includes an imaging system configured to capture image data and event data of a scene, compress the image data and the event data, and transmit the compressed image data and compressed event data to a host. The host is operatively coupled to the imaging system, and includes a processor configured to perform object detection on the compressed image data and the compressed event data to identify one or more objects. The processor is also configured to perform object tracking on the one or more objects. The processor is also configured to predict one or more regions of interest for subsequent data capture based on the object detection and the object tracking. The processor is further configured to provide the one or more regions of interest to the imaging system to control capture of additional image data and additional event data by the imaging system.
FILED Tuesday, August 31, 2021
APPL NO 17/462423
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00771 (20130101)
G06K 9/3233 (20130101) Original (OR) Class

Image Data Processing or Generation, in General
G06T 7/277 (20170101)
G06T 2207/20084 (20130101)
G06T 2207/20192 (20130101)
G06T 2207/30232 (20130101)

Pictorial Communication, e.g Television
H04N 5/23218 (20180801)
H04N 5/23222 (20130101)
H04N 7/183 (20130101)
H04N 7/188 (20130101)
H04N 19/46 (20141101)
H04N 19/96 (20141101)
H04N 19/132 (20141101)
H04N 19/147 (20141101)
H04N 19/167 (20141101)
H04N 19/176 (20141101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067997 Gupta et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
INVENTOR(S) Mohit Gupta (Madison, Wisconsin);  Sizhuo Ma (Madison, Wisconsin)
ABSTRACT In accordance with some embodiments, systems, methods and media for high dynamic range quanta burst imaging are provided. In some embodiments, the system comprises: an image sensor comprising single photon detectors in an array; a processor programmed to: generate a sequence of binary images representing a scene; divide the sequence of binary images into blocks; generate block-sum images from the blocks; determine alignments between the block-sum images and a reference block-sum image; warp the sequence of binary images based on the alignments; generate warped block-sum images using warped binary images; merge the warped block-sum images; display a final image of the scene based on the merged warped block-sum images.
FILED Monday, November 08, 2021
APPL NO 17/521177
CURRENT CPC
Image Data Processing or Generation, in General
G06T 3/0093 (20130101)
G06T 5/009 (20130101)
G06T 5/20 (20130101)
G06T 7/30 (20170101)
G06T 11/60 (20130101) Original (OR) Class
G06T 2207/20208 (20130101)
G06T 2207/20221 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068324 Walker et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Dean E. Walker (Allen, Texas);  Tony Brewer (Plano, Texas)
ABSTRACT A system comprises an interposer including multiple conductive interconnects; multiple chiplets arranged on the interposer and interconnected by the interposer; each chiplet including a die-to-die physical layer interface including one or more pads to engage the interconnect of the interposer; and wherein at least one chiplet includes multiple input-output channels organized into at least one column and arranged in an order at a periphery of the chiplet forming a die-to-die physical layer interface to engage the interconnects of the interposer, wherein the order of the channels of the column is programmable.
FILED Monday, August 31, 2020
APPL NO 17/007876
CURRENT CPC
Electric Digital Data Processing
G06F 9/30101 (20130101)
G06F 13/1694 (20130101)

Static Stores
G11C 7/1006 (20130101) Original (OR) Class
G11C 7/1069 (20130101)
G11C 7/1096 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 23/5382 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068448 Myers et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Medical Research Acquisition Activity (USAMRAA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Vivonics, Inc. (Bedford, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Ryan Myers (North Andover, Massachusetts);  Gordon B. Hirschman (Cohoes, New York)
ABSTRACT A system to electronically coordinate and document pattern care regardless of physical setting. The system includes a wearable subsystem attached to a patient at the point of injury and configured to remain attached to the patient at the point of injury and during one or more encounters with medical personnel or to a time the patient reaches a clinical health care facility. The wearable subsystem is configured to store patient identification information and critical health care information received via wireless communication from an end user computing device at the point of injury and is configured to store added health care information provided by medical personnel from or at the point of injury and during the one or more encounters with the medical personnel or to a time the patient reaches a clinical care facility.
FILED Thursday, November 11, 2021
APPL NO 17/524138
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/6833 (20130101)

Electric Digital Data Processing
G06F 1/163 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/65 (20180101) Original (OR) Class

Wireless Communication Networks
H04W 4/80 (20180201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068536 Guo et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) Boston Applied Technologies, Inc. (Woburn, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Xiaomei Guo (West Roxbury, Massachusetts);  Kewen Kevin Li (Andover, Massachusetts);  Yingyin Kevin Zou (Lexington, Massachusetts);  Hua Jiang (Sharon, Massachusetts)
ABSTRACT A monolithic multiferroic heterostructure fabricated using CSD (chemical solution deposition) is disclosed. The monolithic heterostructure includes a substrate, a ferromagnetic layer, a ferroelectric layer, and one or more seed layers that enhance crystallinity and promote high frequency performance.
FILED Monday, August 31, 2020
APPL NO 17/007321
CURRENT CPC
Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 10/28 (20130101)
H01F 10/30 (20130101)
H01F 10/205 (20130101) Original (OR) Class
H01F 10/265 (20130101)
H01F 41/24 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068584 Connelly et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) US Govt as represented by Secretary of Air Force (Kirtland AFB, New Mexico)
ASSIGNEE(S) Government of the United States, as represented by the Secretary of the Air Force (Kirtland AFB, New Mexico)
INVENTOR(S) Joseph M. Connelly (Albuquerque, New Mexico);  John R. Harris (Albuquerque, New Mexico);  John W. Lewellen (Albuquerque, New Mexico)
ABSTRACT A method for making field emission devices so that they have emitter tips in the form of a needle-like point with a width and length configured such that ratio of the width to the length ranges from about 0.001 to about 0.05, and associated methods for making the tips by 3-D printing.
FILED Thursday, August 26, 2021
APPL NO 17/458158
CURRENT CPC
Electric Discharge Tubes or Discharge Lamps
H01J 9/025 (20130101) Original (OR) Class
H01J 2209/012 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068623 Smith et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E)
MIT Lincoln Laboratory (MITLL)
Federally Funded Research and Development Center (FFRDC)
Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Melissa Alyson Smith (Cambridge, Massachusetts);  Donna-Ruth Yost (Acton, Massachusetts);  Daniel Freeman (Reading, Massachusetts);  Noah Siegel (Las Vegas, Nevada);  Paulo C. Lozano (Arlington, Massachusetts)
ABSTRACT Electrospray devices and methods of fabricating electrospray devices are described
FILED Monday, August 31, 2020
APPL NO 17/007890
CURRENT CPC
Electric Discharge Tubes or Discharge Lamps
H01J 49/165 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069349 KOTOV et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S) Nicholas A. KOTOV (Ypsilanti, Michigan);  Mingqiang WANG (Harbin, China PRC);  Ahmet Emrehan EMRE (Ann Arbor, Michigan)
ABSTRACT A composite solid electrolyte for a solid-state electrochemical cell is provided. The electrolyte may include a plurality of aramid nanofibers, such as a branched aramid nanofiber network, an ionically conductive polymer, such as poly(ethylene oxide) or quaternary ammonia functionalized polyvinyl alcohol (QAFPVA), and an optional divalent ion salt. The electrolyte is particularly suitable for use with zinc ions, where the divalent ion salt may comprise zinc trifluoromethanesulfonate Zn(CF3SO3)2 An electrochemical cell or battery is provided incorporating such a composite solid electrolyte that cycles ions, such as zinc ions or hydroxide ions, suppresses or minimizes dendrite formation, while having good ionic conductivity and being flexible. This flexibility provides the ability to create deformations in the electrochemical cell, such as protrusions and recesses that may define a corrugated pattern. Such a battery may be a rechargeable structural battery with a corrugated surface profile that can be used to form load-bearing structural components.
FILED Monday, January 06, 2020
APPL NO 17/420331
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/502 (20130101)
H01M 10/0565 (20130101) Original (OR) Class
H01M 12/08 (20130101)
H01M 2300/0082 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069479 Wangsvick et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Sea Systems Command (NAVSEA)
APPLICANT(S) Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Chad M. Wangsvick (Tucson, Arizona);  Michael E. Gomez (Tucson, Arizona);  William D. Ake (Tucson, Arizona);  Leonard Santa-Cruz (Tucson, Arizona)
ABSTRACT A datalink such as used on high-speed vehicles (missiles, guided-projectiles, manned or unmanned aircraft) includes an integrated conformal antenna array and out-of-band rejection filter for use with an RF radio. Integration of a single rejection filter between the EME power received by the antenna array and the coaxial RF connector effectively protects the connector as well as the radio. The connector can now be designed based solely on the transmit power requirements of the radio. The resultant connector is smaller and takes up less space inside the vehicle.
FILED Thursday, August 27, 2020
APPL NO 17/004870
CURRENT CPC
Antennas, i.e Radio Aerials
H01Q 1/28 (20130101)
H01Q 5/47 (20150115)
H01Q 21/065 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069523 Hartman et al.
FUNDED BY
Department of Defense (DOD)
Defense MicroElectronics Activity (DMEA)
APPLICANT(S) Raytheon Company (Waltham, Massachusetts)
ASSIGNEE(S) Raytheon Company (, None)
INVENTOR(S) Ryan M. Hartman (Tucson, Arizona);  James F. Morris (Tucson, Arizona)
ABSTRACT A connector retention clip is disclosed. The connector retention clip can include a connector housing having a plurality of connector walls defining a connector opening operable to receive a coupled receptacle and plug connector therein. The plurality of connector walls can include a receptacle end wall and a plug end wall operable to extend about ends of the receptacle and plug, respectively, to provide a mechanical barrier preventing uncoupling of the coupled receptacle and plug connector. In addition, the connector retention clip can include a cable housing extending from the connector housing. The cable housing can have at least one cable wall defining a cable opening operable to receive a cable therein that extends from the coupled receptacle and plug connector.
FILED Friday, August 28, 2020
APPL NO 17/006655
CURRENT CPC
Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors
H01R 12/716 (20130101)
H01R 13/58 (20130101)
H01R 13/508 (20130101)
H01R 13/639 (20130101) Original (OR) Class
H01R 24/76 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069771 CHOU et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E)
MIT Lincoln Laboratory (MITLL)
Federally Funded Research and Development Center (FFRDC)
Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S) Jeffrey CHOU (Walnut Creek, California);  Suraj Deepak BRAMHAVAR (Arlington, Massachusetts);  Siddhartha Ghosh (Cambridge, Massachusetts);  William Herzog (Bedford, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Jeffrey CHOU (Walnut Creek, California);  Suraj Deepak BRAMHAVAR (Arlington, Massachusetts);  Siddhartha Ghosh (Cambridge, Massachusetts);  William Herzog (Bedford, Massachusetts)
ABSTRACT An analog computing system with coupled non-linear oscillators can solve complex combinatorial optimization problems using the weighted Ising model. The system is composed of a fully-connected LC oscillator network with low-cost electronic components and compatible with traditional integrated circuit technologies. Each LC oscillator, or node, in the network can be coupled to each other node in the array with a multiply and accumulate crossbar array or optical interconnects. When implemented with four nodes, the system performs with single-run ground state accuracies of 98% on randomized MAX-CUT problem sets with binary weights and 84% with five-bit weight resolutions. The four-node system can obtain solutions within five oscillator cycles with a time-to-solution that scales directly with oscillator frequency. A scaling analysis suggests that larger coupled oscillator networks may be used to solve computationally intensive problems faster and more efficiently than conventional algorithms.
FILED Friday, March 27, 2020
APPL NO 16/832056
CURRENT CPC
Generation of Oscillations, Directly or by Frequency-changing, by Circuits Employing Active Elements Which Operate in a Non-switching Manner; Generation of Noise by Such Circuits
H03B 5/1212 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069785 Chang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Tammy Chang (San Ramon, California);  Adam Conway (Livermore, California);  Victor Valeryevich Khitrov (San Ramon, California);  Lars Voss (Livermore, Idaho);  Benjamin Fasenfest (Redding, California);  Peter Asbeck (Del Mar, California)
ABSTRACT Power amplifier apparatuses and techniques for optimizing the design of power amplifiers are disclosed. In one aspect, a method for optimizing a power amplifier includes selecting a circuit topology for the power amplifier. The circuit topology includes one or more photoconductive switches and an impedance matching network including one or more parameter values representative of the impedance matching network or the photoconductive switches that can be adjusted. The method further includes selecting one or more optimization goals for the impedance matching network and the one or more photoconductive switches, and adjusting the one or more parameter values according to the one or more optimization goals. The one or more optimization goals include an efficiency at a particular power output.
FILED Tuesday, March 16, 2021
APPL NO 17/202691
CURRENT CPC
Amplifiers
H03F 1/565 (20130101)
H03F 3/195 (20130101)
H03F 3/245 (20130101) Original (OR) Class
H03F 2200/318 (20130101)
H03F 2200/421 (20130101)
H03F 2200/423 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069987 MEDARD et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Muriel MEDARD (Belmont, Massachusetts);  Alejandro COHEN (Brookline, Massachusetts);  Rafael Gregorio Lucas D'OLIVEIRA (Somerville, Massachusetts);  Salman SALAMATIAN (Boston, Massachusetts)
ABSTRACT A system and method provide a hybrid communication scheme that achieves high communication rates with post-quantum computational security guarantees. Messages to be securely communicated are first mixed using an individually secure encoding, such as a linear network code, and some of the encoded messages are further encrypted. The encrypted and unencrypted messages are sent via different communications channels. Each unencrypted message becomes almost as secure as the encrypted messages because of the pre-mixing, since decoding any one of the messages requires all of the messages, including the encrypted messages. Thus, a very few encrypted messages may be used, allowing the rate of communication to approach one as the number of channels increases. This is particularly beneficial when a classical public-key cryptosystem can only be used in part of the data transmitted or stored, in the presence of noisy channels, in distributed data storage, and other applications.
FILED Monday, August 30, 2021
APPL NO 17/460991
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/302 (20130101)
H04L 9/0825 (20130101)
H04L 9/0858 (20130101) Original (OR) Class
H04L 9/3215 (20130101)
H04L 2209/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069990 RYCKMAN et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) CLEMSON UNIVERSITY (Clemson, South Carolina)
ASSIGNEE(S)
INVENTOR(S) JUDSON D. RYCKMAN (CLEMSON, South Carolina);  YINGJIE LAO (CLEMSON, South Carolina);  FARHAN BIN-TARIK (CLEMSON, South Carolina);  AZADEH GHOLAMREZAZADEH-FAMILI (CLEMSON, South Carolina)
ABSTRACT Systems and methods of producing unclonable devices are disclosed. Robust optical physical unclonable function devices use disordered photonic integrated circuits. Optical physical unclonable functions based on speckle patterns, chaos, or ‘strong’ disorder are so far notoriously sensitive to probing and/or environmental variations. A presently disclosed optical physical unclonable function is designed for robustness against fluctuations in optical angular/spatial alignment, polarization, and temperature using an integrated quasicrystal interferometer which sensitively probes disorder. All modes are engineered to exhibit approximately the same confinement factor in the predominant thermo-optic medium (e.g., silicon) and for constraining the transverse spatial-mode and polarization degrees of freedom. Silicon photonic quasicrystal interferometry is used for secure hardware applications.
FILED Tuesday, June 22, 2021
APPL NO 17/354314
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 9/02015 (20130101)

Electric Digital Data Processing
G06F 21/75 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 9/0866 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220070089 Brewer
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Tony Brewer (Plano, Texas)
ABSTRACT Implementations of the present disclosure are directed to systems and methods for flow control using a multiple flit interface. A credit return field is used in a credit-based flow control system to indicate that one or more credits are being returned to a sending device from a receiving device. Based on the number of credits available, the sending device determines whether to send device or wait until more credits are returned. The amount of buffer space used by the receiver to store the packet is determined by the number of transfer cycles used to receive the packet, not the number of flits comprising the packet. This is enabled by having the buffer be as wide as the bus. The receiver returns credits to the sender based on the number of buffer rows used to store the received packet, not the number of flits comprising the packet.
FILED Monday, August 31, 2020
APPL NO 17/007468
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 45/38 (20130101) Original (OR) Class
H04L 45/74 (20130101)
H04L 45/586 (20130101)
H04L 69/22 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220070096 Brewer
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Tony Brewer (Plano, Texas)
ABSTRACT Implementations of the present disclosure are directed to systems and methods for reducing the size of packet headers by using a single field to encode multiple elements. Instead of including separate fields for each element, one or more encoded fields may be used, each of which is decoded to determine two or more values for the data packet. A receiving device decodes the encoded data field to retrieve the two or more values.
FILED Monday, August 31, 2020
APPL NO 17/007354
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 45/302 (20130101)
H04L 45/745 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220070105 Brewer
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) MicronTechnology, Inc (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Tony Brewer (Plano, Texas)
ABSTRACT A transmitting device generates multiple small packets for a large packet and transmits them to a receiving device. Routing devices forward the multiple small packets to the receiving device. Each of the smaller packets, except the last packet, has a sequence indicator set. As a result, the receiving device is able to determine that each of the smaller packets is part of a larger packet and buffer the smaller packets or their payloads. When the last packet is received, the larger packet is complete and may be processed by the receiving device. The routing devices delay requests from other transmitting devices to transmit data to the receiving device until the last packet is sent to the receiving device. The routing devices may continue to route traffic to the receiving device on all virtual channels other than a virtual channel being used for the large packet.
FILED Monday, August 31, 2020
APPL NO 17/007492
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 45/74 (20130101)
H04L 47/34 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220070106 Brewer
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Tony Brewer (Plano, Texas)
ABSTRACT Implementations of the present disclosure are directed to systems and methods for reducing the size of packet headers without reducing the range of packet lengths supported. A packet header includes a fixed-width length field. Using a linear encoding, the maximum packet size is a linear function of the fixed-width length field. Thus, to expand the range of sizes available, either the granularity of the field must be decreased (e.g., by changing the measure of the field from flits to double-flits) or the size of the field must be increased (e.g., by changing the size of the field from 4 bits to 5 bits). However, by using a non-linear encoding, the difference between the minimum and maximum size can be increased without decreasing the granularity within a first range of field values and without increasing the size of the length field.
FILED Monday, August 31, 2020
APPL NO 17/007376
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 45/74 (20130101)
H04L 47/365 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220070107 Pospesel
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Kirk D. Pospesel (Clinton Corners, New York)
ABSTRACT A device allocates buffer space for storing data received from another device. The other device has a credit balance corresponding to the amount of buffer space. A sending device reduces its number of credits by a cost of a packet and sends the packet. To ensure that the buffer does not overflow, the sending device spends a credit for each entry in the buffer that could be consumed by the sent data packet. When received data is added to the buffer without consuming a new entry, a response packet that returns a credit is sent to the sending device before the data is read from the buffer. Thus, the sending device is enabled to continue sending data without waiting for the buffer to be read, enabling the communication between the two devices to make more efficient use of the buffer.
FILED Monday, August 31, 2020
APPL NO 17/007516
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 47/39 (20130101) Original (OR) Class
H04L 47/527 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220070108 Brewer et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) Tony Brewer (Plano, Texas);  David Patrick (McKinney, Texas)
ABSTRACT A credit return field is used in a credit-based flow control system to indicate that one or more credits are being returned to a sending device from a receiving device. Based on the number of credits available, the sending device determines whether to send device or wait until more credits are returned. A write enable mask allows a wide data field to be used even when a smaller amount of data is to be written. A novel data packet uses a combined write enable mask and credit return field. In one mode, the field contains a write enable mask. In another mode, the field contains credit return data. If the field contains credit return data, a default value (e.g., all ones) is used for the write enable mask. The mode may be selected based on another value in the data packet.
FILED Monday, August 31, 2020
APPL NO 17/007701
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 47/39 (20130101) Original (OR) Class
H04L 49/9026 (20130101)
H04L 61/6095 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220070149 Sellers, JR. et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Information Warfare Center (NIWC)
Naval Information Warfare Center Pacific (NIWCPACIFIC)
APPLICANT(S) The United States of America as Represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) William Albert Sellers, JR. (Virginia Beach, Virginia);  James M. Mengert (Virginia Beach, Virginia)
ABSTRACT A secure communication network includes interconnected switches including a source switch, a destination switch, and an intermediate switch. Packets are transferred over the secure communication network from a start node to an end node. The source switch replaces an original payload of each packet with an encrypted payload that combines the original payload and a respective random pad for the packet. The source switch then discards the respective random pad. The source and intermediate switches forward each packet toward the destination switch. The destination switch replaces the encrypted payload of each packet with a decrypted payload, which combines the encrypted payload and the respective random pad so as to match the original payload, discards the respective random pad, and transmits the packet with the decrypted payload to the end node. A controller sends the respective random pad for each packet to the source and destination switches via secure management links.
FILED Tuesday, August 25, 2020
APPL NO 17/002342
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 63/20 (20130101)
H04L 63/0263 (20130101)
H04L 63/0428 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220070196 Sarkar et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona)
ASSIGNEE(S)
INVENTOR(S) Soumajyoti Sarkar (Tempe, Arizona);  Mohammed Almukaynizi (Chandler, Arizona);  Jana Shakarian (Chandler, Arizona);  Paulo Shakarian (Chanlder, Arizona)
ABSTRACT Systems and methods for predicting enterprise cyber incidents using social network analysis on the darkweb hacker forums are disclosed.
FILED Tuesday, October 15, 2019
APPL NO 16/653899
CURRENT CPC
Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 50/01 (20130101)

Transmission of Digital Information, e.g Telegraphic Communication
H04L 63/1433 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220070284 Patrick et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) Micron Technology, Inc. (Boise, Idaho)
ASSIGNEE(S)
INVENTOR(S) David Patrick (McKinney, Texas);  Tony Brewer (Plano, Texas)
ABSTRACT Implementations of the present disclosure are directed to systems and methods for processing headers that support multiple protocols. A header of a packet includes a bridge type (BTYPE) field that indicates the protocol of the packet. A command field of the packet is interpreted differently based on the value of the BTYPE field. Among the benefits of implementations of the present disclosure is that a single network may be used to carry packets of different protocols without the overhead of encapsulation.
FILED Monday, August 31, 2020
APPL NO 17/007748
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 47/2441 (20130101)
H04L 69/16 (20130101)
H04L 69/22 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 20220061236 Guan et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S) Kaiyu Guan (Champaign, Illinois);  Bin Peng (Urbana, Illinois);  Chongya Jiang (Urbana, Illinois);  Wang Zhou (Urbana, Illinois);  Jingwen Zhang (Urbana, Illinois);  Yizhi Huang (Champaign, Illinois);  Jian Peng (Champaign, Illinois);  Sibo Wang (Champaign, Illinois)
ABSTRACT An integrated multi-scale modeling platform is utilized to assess agricultural productivity and sustainability. The model is used to assess the environmental impacts of agricultural management from individual fields to watershed/basin to continental scales. In addition, an integrated irrigation system is developed using data and a machine-learning model that includes weather forecast and soil moisture simulation to determine an irrigation amount for farmers. Next, crop cover classification prediction can be established for an ongoing growing system using a machine learning or statistical model to predict the planted crop type in an area. Finally, a method of predicting key phenology dates of crops for individual field parcels, farms, or parts of a field parcel, in a growing season, can be established.
FILED Wednesday, August 25, 2021
APPL NO 17/445928
CURRENT CPC
Soil Working in Agriculture or Forestry; Parts, Details, or Accessories of Agricultural Machines or Implements, in General
A01B 79/005 (20130101)

Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering
A01G 25/16 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220061321 Piotrowski et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
ASSIGNEE(S) WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin)
INVENTOR(S) Jeff S. Piotrowski (Madison, Wisconsin);  Fachuang Lu (Madison, Wisconsin);  Mehdi Kabbage (Sun Prairie, Wisconsin);  John Ralph (Madison, Wisconsin);  Robert C. Landick (Madison, Wisconsin)
ABSTRACT Antimicrobial diferulates, compositions containing same, and uses of same for inhibiting growth of microorganisms. The antimicrobial diferulates can be used alone or in combination with other antimicrobial agents to inhibit growth of microorganisms such as fungi, oomycetes, and other microorganisms having a glucan-containing cell wall. The antimicrobial diferulates can be included in pharmaceutical compositions for treatment of animals or included in agricultural compositions for treatment of plants, crops, and soils.
FILED Friday, August 27, 2021
APPL NO 17/459180
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 37/38 (20130101) Original (OR) Class
A01N 43/08 (20130101)
A01N 43/12 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/192 (20130101)
A61K 31/343 (20130101)
A61K 45/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062858 CUI et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Renewable Energy Laboratory (NREL)
Federally Funded Research and Development Center (FFRDC)
Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Shuang CUI (Dallas, Texas);  Jason David WOODS (Boulder, Colorado);  Renkun CHEN (San Diego, California);  Paul William MEYER (Lakewood, Colorado)
ABSTRACT The present disclosure relates to thermo-responsive hydrogel composite (TRHC) desiccants having high adsorption capacities, fast adsorption/desorption rates, and low regeneration temperatures (Treg) compared to traditional desiccants. In some embodiments of the present disclosure, TRHC desiccants may be synthesized by freeze drying. In some embodiments of the present disclosure, the porous structures resulting from freeze drying copolymers of thermo-responsive polymers and/or hygroscopic agents may be combined with hygroscopic inorganic salts, resulting in TRHC desiccants having superior performance properties.
FILED Friday, September 03, 2021
APPL NO 17/466054
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/223 (20130101)
B01J 20/264 (20130101) Original (OR) Class
B01J 20/267 (20130101)
B01J 20/28035 (20130101)
B01J 2220/46 (20130101)
B01J 2220/66 (20130101)
B01J 2220/86 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/24 (20130101)
C08J 2333/26 (20130101)
C08J 2351/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062864 Liu et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
INVENTOR(S) Di-Jia Liu (Elmhurst, Illinois);  Tao Xu (Naperville, Illinois);  Haiping Xu (DeKalb, Illinois)
ABSTRACT Electrocatalysts composed of single atoms or metal clusters dispersed over porous carbon support were prepared by a lithium-melt method. The new catalysts demonstrated high selectivity, high Faradic efficiency and low overpotential toward to the electrocatalytic reduction of carbon dioxide to chemicals.
FILED Tuesday, September 01, 2020
APPL NO 17/008853
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 21/18 (20130101)
B01J 23/14 (20130101) Original (OR) Class
B01J 23/18 (20130101)
B01J 35/0033 (20130101)
B01J 37/04 (20130101)
B01J 37/0018 (20130101)

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 3/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062885 Fornasiero et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Francesco Fornasiero (Oakland, California);  Edmond Y. Lau (Dublin, California);  Carlos A. Valdez (San Ramon, California)
ABSTRACT A membrane includes a first layer, and a second layer coupled to the first layer. The second layer includes a network of catalytic sites, each catalytic site having a catalytic center characterized by promoting a chemical reaction of a target material. A method of forming a chemically reactive membrane includes applying a first solution to a structure, the first solution includes a macrocyclic ligand having electron-donating ligands and a side functional group for crosslinking, crosslinking a plurality of the macrocyclic ligand to form a first network of crosslinked macrocyclic ligands, and applying a second solution to the structure, the second solution comprising a catalytic center. Each catalytic center complexes with the electron-donating ligands of each macrocyclic ligand to form catalytic sites in the first network of crosslinked macrocyclic ligands.
FILED Tuesday, September 01, 2020
APPL NO 17/009582
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 35/065 (20130101) Original (OR) Class
B01J 35/1061 (20130101)
B01J 35/1066 (20130101)
B01J 35/1071 (20130101)
B01J 35/1076 (20130101)
B01J 37/0215 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220063186 Selter
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Kansas City National Security Campus (KCNSC)
NNSA Critical Mission Site
Operated by Honeywell Federal Manufacturing & Technologies (FM&T) at Kansas City, MO
APPLICANT(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S) Thomas Matthew Selter (Blue Springs, Missouri)
ABSTRACT A system and method of additively manufacturing a part including fluorine-containing polymers and an additive. The additive may include stainless steel, bronze, molybdenum disulfide, polyimide, or any other suitable additive. The method includes depositing fluorine-containing polymer additive manufacturing material onto a build platform, selectively cross-linking portions of the deposited additive manufacturing material, and curing the selectively cross-linked portions such that at least one characteristic of the part is improved via the additive.
FILED Wednesday, October 13, 2021
APPL NO 17/500191
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/153 (20170801) Original (OR) Class

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 70/10 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064066 Sant et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) The Regents of the University of California (Oakland, California);  Yara International ASA (Oslo, Norway);  BASF Corporation (Beachwood, Ohio)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  Yara International ASA (Oslo, Norway);  BASF Corporation (Beachwood, Ohio)
INVENTOR(S) Gaurav Sant (Los Angeles, California);  Gabriel Falzone (Los Angeles, California);  Tandre Oey (Los Angeles, California);  Wolfram Franke (Los Angeles, California);  Paul Seiler (Los Angeles, California);  Erika La Plante (Los Angeles, California)
ABSTRACT A manufacturing method includes: (1) incorporating at least one soluble, calcium, magnesium, or other divalent cation-containing additive into a concrete mixture including aggregates prone to alkali-silica reaction; and (2) curing the concrete mixture to form a concrete product.
FILED Tuesday, November 16, 2021
APPL NO 17/527948
CURRENT CPC
Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 14/06 (20130101)
C04B 14/22 (20130101)
C04B 20/1074 (20130101)
C04B 22/085 (20130101) Original (OR) Class
C04B 22/124 (20130101)
C04B 28/02 (20130101)
C04B 2103/603 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064140 CHENG et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Zhen CHENG (Mountain View, California);  Hao CHEN (Shanghai, China PRC)
ABSTRACT Provided are delocalized lipophilic cation (DLC) compounds and methods of using such compounds. Also provided are pharmaceutical compositions that include a DLC compound. Provided methods include methods of killing cells and methods of fluorescently labeling mitochondria by contacting the cells with a DLC compound of the present disclosure. Also provided are methods of imaging cell mitochondria, methods of determining whether a patient has a mitochondria related disease, and methods of treating a patient for a mitochondria related disease. Kits that include compounds of the present disclosure are also provided.
FILED Friday, January 10, 2020
APPL NO 17/420254
CURRENT CPC
Heterocyclic Compounds
C07D 401/06 (20130101) Original (OR) Class

Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 23/105 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064391 MURDOCK et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) UNIVERSITY OF SOUTH CAROLINA (COLUMBIA, South Carolina)
ASSIGNEE(S)
INVENTOR(S) LAURA A. MURDOCK (COLUMBIA, South Carolina);  LIHUI WANG (WEST COLUMBIA, South Carolina);  FEI HUANG (WEST COLUMBIA, South Carolina);  BRIAN C. BENICEWICZ (COLUMBIA, South Carolina)
ABSTRACT A novel process for making PBI films starting from gel PBI membranes polymerized and casted in the PPA process wherein acid-imbibed gel PBIs are neutralized in a series of water baths and undergo controlled drying in association with a substrate material, yielding a PBI film without the use of organic solvents.
FILED Tuesday, November 09, 2021
APPL NO 17/522160
CURRENT CPC
Separation
B01D 67/0011 (20130101)
B01D 67/0013 (20130101)
B01D 67/0093 (20130101)
B01D 2323/30 (20130101)
B01D 2323/40 (20130101)
B01D 2325/02 (20130101)
B01D 2325/42 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/2256 (20130101) Original (OR) Class
C08J 2379/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064427 Oakdale et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) James Oakdale (Castro Valley, California);  Sarah E. Baker (Dublin, California);  Nikola Dudukovic (Hayward, California);  Eric B. Duoss (Dublin, California);  Melinda Lia Wah Jue (Livermore, California)
ABSTRACT According to one embodiment, a mixture includes a fluoropolymer monomer having at least one functional group amenable to polymerization, a pore-forming material, and a polymerization initiator. According to another embodiment, a product includes a porous three-dimensional structure comprising a crosslinked fluoropolymer, where at least 20% of a volume measured within an outer periphery of the porous three-dimensional structure corresponds to the pores.
FILED Friday, August 28, 2020
APPL NO 17/006462
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 39/003 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 9/008 (20130101)
C08J 9/228 (20130101)

Compositions of Macromolecular Compounds
C08L 27/18 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064437 OZCAN et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee);  FiberLean Technologies Limited (Par Cornwall, United Kingdom)
ASSIGNEE(S)
INVENTOR(S) Soydan OZCAN (Oak Ridge, Tennessee);  Kai LI (Knoxville, None);  Halil TEKINALP (Knoxville, Tennessee);  Xianhui ZHAO (Oak Ridge, Tennessee);  Jon PHIPPS (Gorran Haven Cornwall, United Kingdom);  Sean IRELAND (Hampden, Maine)
ABSTRACT A process for producing dried, vinyl carboxylate surface-modified microfibrillated cellulose having improved mechanical properties and a microfibril structure and a process for producing a vinyl carboxylate, surface-modified microfibrillated cellulose—thermoplastic polyester or thermoplastic polyolefin composite material having improved mechanical strength properties utilizing dried, vinyl carboxylate surface-modified microfibrillated cellulose.
FILED Friday, July 09, 2021
APPL NO 17/371581
CURRENT CPC
Polysaccharides; Derivatives Thereof
C08B 3/08 (20130101)

Compositions of Macromolecular Compounds
C08L 1/10 (20130101)
C08L 67/04 (20130101) Original (OR) Class
C08L 2205/16 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064463 Perez et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S) Lawrence Livermore National Security, LLC (, None)
INVENTOR(S) Lemuel Perez Perez (Livermore, California);  Eric B. Duoss (Dublin, California);  Jeremy Lenhardt (Tracy, California);  Thomas S. Wilson (San Leandro, California)
ABSTRACT A product of additive manufacturing with a silicone-based ink includes a plurality of continuous filaments comprised of a siloxane matrix, wherein the continuous filaments are arranged in a geometric pattern, a plurality of inter-filament pores defined by the geometric pattern of the continuous filaments, and a plurality of intra-filament pores having an average diameter in a range of greater than 1 micron to less than 50 microns.
FILED Tuesday, October 12, 2021
APPL NO 17/499641
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 70/00 (20141201)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 77/20 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 9/26 (20130101)
C08J 2201/042 (20130101)

Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients
C08K 3/013 (20180101)
C08K 3/36 (20130101)
C08K 5/21 (20130101)
C08K 7/22 (20130101)
C08K 9/06 (20130101)
C08K 2201/003 (20130101)
C08K 2201/006 (20130101)

Compositions of Macromolecular Compounds
C08L 71/02 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 11/16 (20130101) Original (OR) Class
C09D 11/101 (20130101)
C09D 11/102 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064481 Rodriguez et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Kansas City National Security Campus (KCNSC)
NNSA Critical Mission Site
Operated by Honeywell Federal Manufacturing & Technologies (FM&T) at Kansas City, MO
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California);  Honeywell Federal Manufacturing and Technologies, LLC. (Kansas City, Missouri)
ASSIGNEE(S)
INVENTOR(S) Jennifer Nicole Rodriguez (Lathrop, California);  Eric B. Duoss (Dublin, California);  Alexandra Golobic (Pleasanton, California);  Jeremy M. Lenhardt (Tracy, California);  Lemuel Perez Perez (Livermore, California);  Ward Small, IV (Livermore, California);  Thomas S. Wilson (San Leandro, California);  Amanda Wu (Dublin, California);  Timothy Dexter Yee (Alameda, California);  Stephanie Schulze (Lenexa, Kansas)
ABSTRACT A product includes a porous three-dimensional printed structure having printed filaments arranged in a geometric pattern. The printed filaments include a material having a plurality of gas-filled microballoons. The printed structure has hierarchical porosity including an inter-filament porosity defined by the arrangement of the printed filaments, and an intra-filament porosity of the material. The intra-filament porosity is defined by the plurality of gas-filled microballoons in the material of the printed filament.
FILED Tuesday, November 09, 2021
APPL NO 17/522677
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 70/00 (20141201)
B33Y 80/00 (20141201)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 7/70 (20180101)
C09D 183/04 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064625 Qian et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Renewable Energy Laboratory (NREL)
Federally Funded Research and Development Center (FFRDC)
Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California);  Alliance for Sustainable Energy, LLC. (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Fang Qian (Santa Cruz, California);  Sarah E. Baker (Dublin, California);  Joshua R. Deotte (Livermore, California);  Eric B. Duoss (Dublin, California);  Nathan C. Ellebracht (Oakland, California);  Jennifer Marie Knipe (Oakland, California);  Samantha Ruelas (Newberry Springs, California);  Hawi Bacha Gemeda (San Leandro, California);  Michael Guarnieri (Denver, Colorado)
ABSTRACT A method for forming a product from a gas includes flowing a gas through a bioreactor for contacting the gas with polymer-immobilized whole cells and collecting the product from the bioreactor. The bioreactor includes a plurality of printed three-dimensional structures, each printed three-dimensional structure having at least one sidewall being a lattice, and the polymer-immobilized whole cells being present in the lattice.
FILED Tuesday, November 09, 2021
APPL NO 17/522726
CURRENT CPC
Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)

Apparatus for Enzymology or Microbiology;
C12M 21/02 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 11/04 (20130101)
C12N 11/089 (20200101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064693 Justice et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California (UC BERKELEY) at Berkeley, CA
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Nicholas B. Justice (Oakland, California);  Adam P. Arkin (San Francisco, California)
ABSTRACT Disclosed herein are methods, compositions, and systems for determining specific microbial taxa, within a complex consortia of mixed taxa, which are interacting with each other in an environment of interest. In some embodiments, after diluting a sample comprising multiple different taxa of microorganisms, dilutions of the sample are cultivated for determining taxonomic information and interactions of multiple taxa of microorganisms in the sample.
FILED Monday, May 24, 2021
APPL NO 17/328167
CURRENT CPC
Beer; Preparation of Beer by Fermentation; Preparation of Malt for Making Beer; Preparation of Hops for Making Beer
C12C 1/02 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/02 (20130101) Original (OR) Class
C12Q 1/025 (20130101)
C12Q 1/689 (20130101)
C12Q 2600/158 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 40/00 (20190201)
G16B 40/20 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064759 Zhang et al.
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S) University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)
INVENTOR(S) Wencai Zhang (Lexington, Kentucky);  Rick Q. Honaker (Lexington, Kentucky)
ABSTRACT The present invention concerns a process of selective precipitation for the purpose of recovering rare earth elements from acidic media derived from coal and coal byproducts via two main steps of sequential precipitation and selective precipitation. An intermediary step of re-precipitation can be included to further increase RRE concentrations, as well as improve contaminant metal removal.
FILED Thursday, September 09, 2021
APPL NO 17/470690
CURRENT CPC
Production and Refining of Metals; Pretreatment of Raw Materials
C22B 3/22 (20130101)
C22B 3/44 (20130101)
C22B 59/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064806 Feaster et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Jeremy Taylor Feaster (Fremont, California);  Sarah Baker (Dublin, California);  Daniel Corral (Fremont, California);  Eric Duoss (Dublin, California)
ABSTRACT System and method relates to an advanced manufactured vapor-fed electrochemical reactor (AM-VFR) system comprising a cathode gas compartment comprising a first inlet, and a first outlet, a catholyte compartment having a centrally located window for a cathode and a membrane, a second inlet, a second outlet, and a reference electrode, an anolyte compartment having a centrally located window for the membrane and an anode, a third inlet and a third outlet and an anode gas compartment having a fourth inlet and a fourth outlet, wherein the cathode, wherein the cathode is disposed between the cathode gas compartment and the catholyte compartment, wherein the membrane is disposed between the catholyte compartment and the anolyte compartment, wherein the anode is disposed between the anolyte compartment and the anode gas compartment, and wherein one or more of the cathode gas compartment, the catholyte compartment, the anolyte compartment and the anode gas compartment are made of a 3D printing plastic. Methods for making and using the system are also disclosed.
FILED Wednesday, September 02, 2020
APPL NO 17/010680
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/124 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 80/00 (20141201)

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 1/00 (20130101)
C25B 9/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065452 Berry et al.
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) Jonathan Dwight Berry (Simpsonville, South Carolina);  Jerome Walter Goike (Greenville, South Carolina);  Clay Thomas Griffis (Greenville, South Carolina)
ABSTRACT An integrated combustor nozzle includes a combustion liner that extends between an inner liner segment and an outer liner segment along a radial direction. The combustion liner including a forward end portion, an aft end portion, a first side wall, and a second side wall. An impingement panel having an impingement plate disposed along an exterior surface of one of the inner liner segment or the outer liner segment. The impingement plate defines a plurality of impingement apertures that direct coolant in discrete jets towards the exterior surface of the inner liner segment or the outer liner segment. The impingement panel includes an inlet portion that extends from the impingement plate to a collection duct. The impingement panel further includes a plurality of supports spaced apart from one another. The plurality of supports extend between, and are coupled to, the inlet portion, the collection duct, and the impingement plate
FILED Monday, August 31, 2020
APPL NO 17/007108
CURRENT CPC
Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 9/02 (20130101)
F01D 25/12 (20130101)

Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants
F05D 2220/323 (20130101)
F05D 2260/201 (20130101)
F05D 2260/22141 (20130101)

Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers
F23R 3/002 (20130101) Original (OR) Class
F23R 2900/03044 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065453 Berry et al.
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) Jonathan Dwight Berry (Simpsonville, South Carolina);  Michael John Hughes (State College, Pennsylvania)
ABSTRACT An integrated combustor nozzle includes a combustion liner that extends radially between an inner liner segment and an outer liner segment. The combustion liner includes a forward end portion, an aft end portion, a first side wall, and a second side wall. The aft end portion of the combustion liner defines a turbine nozzle. The integrated combustor nozzle further includes an impingement panel having an impingement plate disposed along an exterior surface of one of the inner liner segment or the outer liner segment. The impingement plate defines a plurality of impingement holes that direct coolant in discrete jets towards the exterior surface of the inner liner segment or the outer liner segment. The impingement panel is radially spaced from the exterior surface to form a cooling flow gap therebetween. The impingement panel includes a collection duct that extends from the impingement panel and defines a collection passage.
FILED Monday, August 31, 2020
APPL NO 17/007068
CURRENT CPC
Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers
F23R 3/06 (20130101) Original (OR) Class
F23R 3/26 (20130101)
F23R 3/283 (20130101)
F23R 2900/03044 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065454 Berry et al.
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S) General Electric Company (Schenectady, New York)
ASSIGNEE(S)
INVENTOR(S) Jonathan Dwight Berry (Simpsonville, South Carolina);  Michael John Hughes (State College, Pennsylvania)
ABSTRACT Integrated combustor nozzles and turbomachines are provided. An integrated combustor nozzle includes a cooling insert having a flange. The cooling insert further includes a first wall and a second wall that each define respective passages therein. The first wall and the second wall each extend from an open end defined within the flange to a closed end. The first wall and the second wall each include an impingement side spaced apart from a solid side. Each impingement side defines a plurality of impingement apertures configured to direct coolant from the respective passage towards a side wall of the combustion liner. The cooling inserts further includes a collection passageway that is defined between the solid sides of the first wall and the second wall.
FILED Monday, August 31, 2020
APPL NO 17/007076
CURRENT CPC
Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers
F23R 3/06 (20130101) Original (OR) Class
F23R 3/26 (20130101)
F23R 2900/03044 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065816 Ibrahim et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Pacific Northwest National Laboratory (PNNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Memorial Institute (BMI) at Richland, WA
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Yehia M. Ibrahim (West Richland, Washington);  Adam L. Hollerbach (Richland, Washington);  Ailin Li (Richland, Washington)
ABSTRACT An apparatus includes multiple levels of ion transport channels, with successive levels coupled by elevator channels. Efficient three dimensional packing provides long path lengths in practical volumes for ion mobility separation with high resolving power. Disclosed elevator configurations provide efficient routing of ion transport channels across levels with low ion loss, enabling ion mobility separation over 100 levels or more. Elevator configurations include (i) opposed traveling waves meeting at an elevator entrance, (ii) external elevator with a wrap-around electrode bank, (iii) external elevator with electrode banks on parallel extension plates, or (iv) elevator operating in surfing mode, in various combinations. Manufacture is aided by printed wiring boards, with interchangeable boards. Assembly with motherboard, spacer block(s), and alignment pins provides efficient distribution of electrode excitations and accurate reproducible positioning.
FILED Wednesday, August 11, 2021
APPL NO 17/399629
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/68 (20130101)
G01N 27/622 (20130101) Original (OR) Class

Electric Discharge Tubes or Discharge Lamps
H01J 49/061 (20130101)
H01J 49/062 (20130101)
H01J 49/4225 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065919 Ahmed et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Moinuddin Ahmed (Darien, Illinois);  John N. Hryn (Hawthorn Woods, Illinois);  Christopher Stankus (Hampshire, Illinois)
ABSTRACT A method for predicting failure parameters of semiconductor devices can include receiving a set of data that includes (i) characteristics of a sample semiconductor device, and (ii) parameters characterizing a stress condition. The method further includes extracting a plurality of feature values from the set of data and inputting the plurality of feature values into a trained model executing on the one or more processors, wherein the trained model is configured according to an artificial intelligence (AI) algorithm based on a previous plurality of feature values, and wherein the trained model is operable to output a failure prediction based on the plurality of feature values. Further, the method includes generating, via the trained model, a predicted failure parameter of the sample semiconductor device due to the stress condition.
FILED Friday, July 23, 2021
APPL NO 17/383776
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/2642 (20130101) Original (OR) Class
G01R 31/2848 (20130101)
G01R 31/2874 (20130101)
G01R 31/2879 (20130101)
G01R 31/2881 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220066070 Kozodoy et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) Glint Photonics, Inc. (Burlingame, California)
ASSIGNEE(S)
INVENTOR(S) Peter Kozodoy (Palo Alto, California);  John Lloyd (San Mateo, California)
ABSTRACT Methods for forming optical articles with antireflective nanostructured (ARN) surfaces. An aluminum layer is deposited or otherwise applied to the cavity of an injection mold tool. Sequential chemical treatments such as anodization and etching steps form an ARN mold texture on the interior surface of the cavity. The ARN mold texture is a negative of a desired surface texture of the article. During injection molding, the desired ARN surface is thereby produced in the optical article.
FILED Tuesday, April 27, 2021
APPL NO 17/241151
CURRENT CPC
Producing Particular Articles From Plastics or From Substances in a Plastic State
B29D 11/00865 (20130101)

Optical Elements, Systems, or Apparatus
G02B 1/118 (20130101) Original (OR) Class
G02B 2207/101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068511 LAHODA et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
APPLICANT(S) Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania)
ASSIGNEE(S) Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania)
INVENTOR(S) Edward J. LAHODA (Edgewood, Pennsylvania);  Peng XU (Columbia, South Carolina);  Robert L. OELRICH, JR. (Columbia, South Carolina);  Hemant SHAH (Columbia, South Carolina);  Jonathan WRIGHT (Vasteras, Sweden);  Lu CAI (Columbia, South Carolina)
ABSTRACT A method of forming a water resistant boundary on a fissile material for use in a water cooled nuclear reactor is described. The method comprises mixing a powdered fissile material selected from the group consisting of UN and U3Si2 with an additive selected from oxidation resistant materials having a melting or softening point lower than the sintering temperature of the fissile material, pressing the mixed fissile and additive materials into a pellet, sintering the pellet to a temperature greater than the melting point of the additive. Alternatively, if the melting point of the oxidation resistant particles is greater than the sintering temperature of UN or U3Si2, then the oxidation resistant particles can have a particle size distribution less than that of the UN or U3Si2
FILED Monday, September 13, 2021
APPL NO 17/473433
CURRENT CPC
Nuclear Reactors
G21C 3/22 (20130101)
G21C 3/045 (20190101)
G21C 3/62 (20130101)
G21C 3/626 (20130101) Original (OR) Class
G21C 21/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068513 Stauff et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
APPLICANT(S) UCHICAGO ARGONNE, LLC (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Nicolas E. Stauff (Oak Park, Illinois);  Yinbin Miao (Naperville, Illinois);  Abdellatif M. Yacout (Naperville, Illinois);  Taek K. Kim (Naperville, Illinois)
ABSTRACT A heat transfer module can include an envelope sealed to define an internal volume that contains a working fluid and a wick disposed on an internal surface of the envelope. The wick and envelope each has a first portion extending through an evaporator region and a second portion extending through adiabatic and condenser regions. The first portion of the wick is a metal hydride. The first portion of the envelope includes a metal liner surrounding the first portion of the wick, a first diffusion barrier layer disposed between the first portion of the wick and the metal liner, and a ceramic matrix composite cladding surrounding the metal liner. The second portions of the wick and envelope each includes a refractory metal and/or stainless steel.
FILED Thursday, September 03, 2020
APPL NO 17/011744
CURRENT CPC
Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact
F28D 15/046 (20130101)

Details of Heat-exchange and Heat-transfer Apparatus, of General Application
F28F 21/081 (20130101)

Nuclear Reactors
G21C 15/257 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068632 MONAVARIAN et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Morteza MONAVARIAN (Albuquerque, New Mexico);  Daniel FEEZELL (Albuquerque, New Mexico);  Andrew ARAGON (Albuquerque, New Mexico);  Saadat MISHKAT-UL-MASABIH (Albuquerque, New Mexico);  Andrew ALLERMAN (Tijeras, New Mexico);  Andrew ARMSTRONG (Albuquerque, New Mexico);  Mary CRAWFORD (Albuquerque, New Mexico)
ABSTRACT A method comprises providing a substrate comprising an n-type Al/In/GaN semiconductor material. A surface of the substrate is dry-etched to form a trench therein and cause dry-etch damage to remain on the surface. The surface of the substrate is immersed in an electrolyte solution and illuminated with above bandgap light having a wavelength that generates electron-hole pairs in the n-type Al/In/GaN semiconductor material, thereby photoelectrochemically etching the surface to remove at least a portion of the dry-etch damage.
FILED Friday, November 12, 2021
APPL NO 17/525516
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/0254 (20130101)
H01L 21/02057 (20130101) Original (OR) Class
H01L 21/02389 (20130101)
H01L 21/02433 (20130101)
H01L 21/3065 (20130101)
H01L 21/30612 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069157 SCHULTE et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
Office of Energy Efficiency and Renewable Energy (EERE)
National Renewable Energy Laboratory (NREL)
Federally Funded Research and Development Center (FFRDC)
Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado);  MASSACHUSETTS INSTITUTE OF TECHNONLOGY (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Kevin Louis SCHULTE (Denver, Colorado);  Myles Aaron STEINER (Denver, Colorado);  Daniel Joseph FRIEDMAN (Lakewood, Colorado);  Ryan Matthew FRANCE (Golden, Colorado);  Asegun HENRY (Boston, Massachusetts)
ABSTRACT The present disclosure relates to a method for manufacturing a device, where the device includes, in order, a metamorphic contact layer, a first metamorphic junction, a metamorphic tunnel junction, and a second metamorphic junction. To produce the device, the manufacturing includes, in order, a first depositing of a buffer layer onto a substrate, a second depositing of the metamorphic contact layer, a third depositing of the first metamorphic junction, a fourth depositing of the metamorphic tunnel junction, a fifth depositing of the second metamorphic junction, and the removing of the buffer layer and the substrate.
FILED Monday, August 30, 2021
APPL NO 17/460829
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 31/1844 (20130101) Original (OR) Class
H01L 31/1892 (20130101)
H01L 31/06875 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069270 Yersak et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) GM Global Technology Operations LLC (Detroit, Michigan)
ASSIGNEE(S)
INVENTOR(S) Thomas A. Yersak (Royal Oak, Michigan);  James R. Salvador (East Lansing, Michigan);  Fang Hao (Sterling Heights, Michigan);  Chansoon Kang (Troy, Michigan)
ABSTRACT A battery comprises a positive current collector that contacts a composite cathode and a negative current collector that supports an anode. The anode is opposedly disposed to the composite cathode. A compliant interlayer and a separator are located between the anode and the composite cathode, where the compliant interlayer comprises a compliant electrolyte. The separator is in a protective relationship with the cathode and prevents the compliant electrolyte from contacting the composite cathode.
FILED Thursday, September 03, 2020
APPL NO 17/011640
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 2/1646 (20130101)
H01M 2/1666 (20130101) Original (OR) Class
H01M 4/134 (20130101)
H01M 10/0525 (20130101)
H01M 10/0563 (20130101)
H01M 2004/027 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069315 Wu et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) The Research Foundation for The State University of New York (Buffalo, New York);  Giner, Inc. (Newton, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Gang Wu (Clarence Center, New York);  Hui Xu (Acton, Massachusetts);  Mengjie Chen (Buffalo, New York);  Fan Yang (Acton, Massachusetts)
ABSTRACT Atomically dispersed platinum-group metal-free catalyst and method for synthesizing the same. According to one embodiment, the catalyst is made by a method in which, in a first step, an Mn-doped ZIF-8 catalyst precursor is prepared by reacting a first solution comprising zinc nitrate hexahydrate and manganese chloride dissolved in an acid/water solution with a second solution comprising 2-methylimidazole dissolved in water. Then, in a second step, the Mn-doped ZIF-8 catalyst precursor is thermally activated, i.e., carbonized, to form an Mn—N—C catalyst. Preferably, the thermal activation is performed in a multistep fashion, first at a lower temperature of about 800° C. and then at a higher temperature of about 1100° C. After carbonization, the catalyst material may optionally be subjected to an absorption process, followed by a second thermal activation. The absorption process may involve dispersing the catalyst material in a solution of manganese chloride and urea in hydrochloric acid and isopropanol.
FILED Wednesday, September 01, 2021
APPL NO 17/464458
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/90 (20130101) Original (OR) Class
H01M 8/1004 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069577 DeSalvo et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) Delphire Inc. (PASADENA, California)
ASSIGNEE(S)
INVENTOR(S) Gilberto DeSalvo (Pasadena, California);  Matthew D. Smalley (Newhall, California)
ABSTRACT Electrical transmission lines (e.g. overhead lines), associated equipment, and proximal environment monitoring by data acquisition units (DAUs) that provide information that (1) can directly indicate a critical event occurrence or that can trigger operator review, (2) can be processed alone or in combination to ascertain the occurrence of such an event or that can trigger operator review, and/or (3) can be processed by trained AI software to provide an event inference. In some embodiments, enhanced risk of event occurrence can be ascertained to provide modified system behavior and/or to provide a proactive advanced mitigation response. Events of interest include, for example: fire, powerline obstruction or interference, physical line failure, excessive line movement, excessive ground movement, excessive arcing, and the like.
FILED Wednesday, September 01, 2021
APPL NO 17/446696
CURRENT CPC
Meteorology
G01W 1/10 (20130101)

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 3/0012 (20200101)
H02J 3/0073 (20200101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069785 Chang et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S) Tammy Chang (San Ramon, California);  Adam Conway (Livermore, California);  Victor Valeryevich Khitrov (San Ramon, California);  Lars Voss (Livermore, Idaho);  Benjamin Fasenfest (Redding, California);  Peter Asbeck (Del Mar, California)
ABSTRACT Power amplifier apparatuses and techniques for optimizing the design of power amplifiers are disclosed. In one aspect, a method for optimizing a power amplifier includes selecting a circuit topology for the power amplifier. The circuit topology includes one or more photoconductive switches and an impedance matching network including one or more parameter values representative of the impedance matching network or the photoconductive switches that can be adjusted. The method further includes selecting one or more optimization goals for the impedance matching network and the one or more photoconductive switches, and adjusting the one or more parameter values according to the one or more optimization goals. The one or more optimization goals include an efficiency at a particular power output.
FILED Tuesday, March 16, 2021
APPL NO 17/202691
CURRENT CPC
Amplifiers
H03F 1/565 (20130101)
H03F 3/195 (20130101)
H03F 3/245 (20130101) Original (OR) Class
H03F 2200/318 (20130101)
H03F 2200/421 (20130101)
H03F 2200/423 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220071003 WANG et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Joseph WANG (San Diego, California);  Rajan Kumar (La Jolla, California);  Ying Shirley Meng (San Diego, California);  Jae Wook Shin (La Jolla, California);  Lu Yin (San Diego, California)
ABSTRACT Disclosed are compositions, devices, systems and fabrication methods for stretchable composite materials and stretchable electronics devices. In some aspects, an elastic composite material for a stretchable electronics device includes a first material having a particular electrical, mechanical or optical property; and a multi-block copolymer configured to form a hyperelastic binder that creates contact between the first material and the multi-block copolymer, in which the elastic composite material is structured to stretch at least 500% in at least one direction of the material and to exhibit the particular electrical, mechanical or optical property imparted from the first material. In some aspects, the stretchable electronics device includes a stretchable battery, biofuel cell, sensor, supercapacitor or other device able to be mounted to skin, clothing or other surface of a user or object.
FILED Wednesday, October 13, 2021
APPL NO 17/500931
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/1477 (20130101)
A61B 5/14865 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 297/046 (20130101)

Compositions of Macromolecular Compounds
C08L 53/02 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/38 (20130101)
H01M 4/48 (20130101)
H01M 4/622 (20130101)
H01M 4/663 (20130101)
H01M 4/666 (20130101)
H01M 4/668 (20130101)
H01M 10/24 (20130101)

Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/16 (20130101)
H05K 1/028 (20130101)
H05K 1/118 (20130101)
H05K 1/0283 (20130101) Original (OR) Class
H05K 1/0393 (20130101)
H05K 3/326 (20130101)
H05K 2201/0133 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 20220061236 Guan et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S) Kaiyu Guan (Champaign, Illinois);  Bin Peng (Urbana, Illinois);  Chongya Jiang (Urbana, Illinois);  Wang Zhou (Urbana, Illinois);  Jingwen Zhang (Urbana, Illinois);  Yizhi Huang (Champaign, Illinois);  Jian Peng (Champaign, Illinois);  Sibo Wang (Champaign, Illinois)
ABSTRACT An integrated multi-scale modeling platform is utilized to assess agricultural productivity and sustainability. The model is used to assess the environmental impacts of agricultural management from individual fields to watershed/basin to continental scales. In addition, an integrated irrigation system is developed using data and a machine-learning model that includes weather forecast and soil moisture simulation to determine an irrigation amount for farmers. Next, crop cover classification prediction can be established for an ongoing growing system using a machine learning or statistical model to predict the planted crop type in an area. Finally, a method of predicting key phenology dates of crops for individual field parcels, farms, or parts of a field parcel, in a growing season, can be established.
FILED Wednesday, August 25, 2021
APPL NO 17/445928
CURRENT CPC
Soil Working in Agriculture or Forestry; Parts, Details, or Accessories of Agricultural Machines or Implements, in General
A01B 79/005 (20130101)

Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering
A01G 25/16 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220061319 Marenda et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Organismal Systems (IOS)
APPLICANT(S) Drexel University (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Daniel R. Marenda (Elkins Park, Pennsylvania);  Sean O'Donnell (Swarthmore, Pennsylvania)
ABSTRACT The disclosure provides a human-safe method of killing or controlling insects using a non-toxic composition comprising erythritol ((2R,3S)-butane-1,2,3,4-tetraol). The disclosure also provides non-toxic compositions comprising erythritol suitable for killing insects in residential, commercial, and agricultural locales.
FILED Friday, September 03, 2021
APPL NO 17/466977
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 25/006 (20130101)
A01N 25/10 (20130101)
A01N 25/30 (20130101)
A01N 31/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220061705 EMAMINEJAD et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) The Regents of the University of California (, None)
ASSIGNEE(S)
INVENTOR(S) Sam EMAMINEJAD (Los Angeles, California);  Haisong LIN (Los Angeles, California);  Jiawei TAN (Los Angeles, California)
ABSTRACT Active biofluid management may be advantageous to the realization of wearable bioanalytical platforms that can autonomously provide frequent, real-time, and accurate measures of biomarkers in epidermally-retrievable biofluids (e.g., sweat). Accordingly, exemplary implementations include a programmable epidermal microfluidic valving system capable of biofluid sampling, routing, and compartmentalization for biomarker analysis. An exemplary system includes a network of individually-addressable microheater-controlled thermo-responsive hydrogel valves, augmented with a pressure regulation mechanism to accommodate pressure built-up, when interfacing sweat glands. The active biofluid control achieved by this system may be harnessed to create unprecedented wearable bioanalytical capabilities at both the sensor level (decoupling the confounding influence of flow rate variability on sensor response) and the system level (facilitating context-based sensor selection/protection). Through integration with a wireless flexible printed circuit board and seamless bilateral communication with consumer electronics (e.g., smartwatch), contextually-relevant (scheduled/on-demand) on-body biomarker data acquisition/display may be achieved.
FILED Wednesday, August 04, 2021
APPL NO 17/394208
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0002 (20130101)
A61B 5/259 (20210101)
A61B 5/681 (20130101)
A61B 5/14517 (20130101) Original (OR) Class

Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502707 (20130101)
B01L 3/502715 (20130101)
B01L 3/502738 (20130101)
B01L 7/00 (20130101)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 40/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0006 (20130101)
C12N 9/0069 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/14 (20130101)
G01N 27/301 (20130101)
G01N 27/3273 (20130101)
G01N 33/48707 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062234 NGO et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
ASSIGNEE(S) TRUSTEES OF BOSTON UNIVERSITY (Boston, Massachusetts)
INVENTOR(S) John T. NGO (Cambridge, Massachusetts);  Mary DUNLOP (Newton, Massachusetts);  Elliot Parker TAGUE (Brookline, Massachusetts);  Nathan Michael TAGUE (Brookline, Massachusetts);  Alexander Michael MARZILLI (Cambridge, Massachusetts)
ABSTRACT The technology described herein is directed to polypeptide systems using drug-controlled peptide docking domains and cognate docking domain-binding peptides and their use to control cellular signaling, activity, and/or gene expression.
FILED Tuesday, August 31, 2021
APPL NO 17/462185
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/404 (20130101) Original (OR) Class
A61K 31/4965 (20130101)
A61K 31/5377 (20130101)
A61K 47/6425 (20170801)

Peptides
C07K 14/02 (20130101)
C07K 14/47 (20130101)
C07K 14/705 (20130101)
C07K 14/43595 (20130101)
C07K 2319/03 (20130101)
C07K 2319/60 (20130101)
C07K 2319/80 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1241 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062432 Shah et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Sagar Ramesh Shah (Clemson, South Carolina);  Juan Carlos Martinez-Gutierrez (Baltimore, Maryland);  Alejandro Ruiz-Valls (Baltimore, Maryland);  Ran Lin (Baltimore, Maryland);  Honggang Cui (Lutherville, Maryland);  Alfredo Quinones-Hinojosa (Bel Air, Maryland)
ABSTRACT The present invention provides compositions comprising Verteporfin and other anticancer compounds linked to a hydrophilic peptide through a degradable linker molecule to allow the anticancer compounds to penetrate tissues via in situ administration. The compounds of the present invention are useful for sensitizing tumor cells to radiotherapy, preventing recurrence of tumors after surgical resection and for treating remaining unremoved cancer cells at the site of the tumor.
FILED Friday, September 10, 2021
APPL NO 17/471592
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/409 (20130101)
A61K 41/0038 (20130101)
A61K 47/64 (20170801) Original (OR) Class
A61K 47/6903 (20170801)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/10 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062507 Cao et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S) Qing Cao (Urbana, Illinois);  Yi Zhang (Urbana, Illinois)
ABSTRACT Nanostructured thin films and methods of their manufacture are disclosed. An example method of manufacturing includes forming a colloidal crystal mask on a template substrate so as to partially mask the template substrate. The method additionally includes etching the exposed potions of the template substrate to form a plurality of holes within the template substrate corresponding to the plurality of holes in the first thin film. The method yet further includes depositing a second thin film on the etched template substrate to form a nanostructured thin film. The nanostructured thin film includes a nanopillar array disposed along a first surface of a flexible substrate. The flexible substrate and the nanopillar array comprise a polymer material.
FILED Monday, August 30, 2021
APPL NO 17/460561
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/16 (20130101)
A61L 27/34 (20130101)
A61L 27/54 (20130101) Original (OR) Class
A61L 2300/404 (20130101)
A61L 2300/606 (20130101)
A61L 2400/12 (20130101)
A61L 2420/02 (20130101)

Processes for Applying Fluent Materials to Surfaces, in General
B05D 1/005 (20130101)
B05D 1/322 (20130101)
B05D 3/145 (20130101)
B05D 5/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062959 Campanella et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Wareham, Massachusetts)
ASSIGNEE(S) Loci Controls, Inc. (Wareham, Massachusetts)
INVENTOR(S) Andrew Campanella (Somerville, Massachusetts);  Joseph G. Michels (New York, New York);  Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts)
ABSTRACT A control system for controlling extraction of landfill gas, comprising: at least one sensor configured to measure one or more characteristics of landfill gas; at least one flow control mechanism disposed in well piping and configured to control flow of the landfill gas through the well piping; and at least one processor configured to: obtain a measured concentration of a first gas in landfill gas; determine whether the measured concentration of the first gas is either less than a first threshold concentration or greater than a second threshold concentration; when it is determined that the measured concentration is less than the first threshold concentration, control the at least one flow control mechanism to reduce flow rate of landfill gas; and when it is determined that the concentration is greater than the second threshold concentration, control the at least one flow control mechanism to increase the flow rate of landfill gas.
FILED Wednesday, July 07, 2021
APPL NO 17/369318
CURRENT CPC
Disposal of Solid Waste
B09B 1/006 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 43/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220063110 KONG et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Development Command (USAMRDC)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) The Board of Trustees of the University of Illinois (Urbana, Illinois);  Purdue Research Foundation (, None)
ASSIGNEE(S)
INVENTOR(S) Hyunjoon KONG (Urbana, Illinois);  Byoungsoo KIM (Urbana, Illinois);  Jonghwi LEE (Urbana, Illinois);  Chi Hwan LEE (West Lafayette, Indiana);  Min Ku KIM (Lafayette, Indiana)
ABSTRACT Provided herein are manipulators for handling fragile layers and related methods of handling using the manipulators. The manipulators comprise a contact surface with thermally responsive recess features and a microelectric heater in thermal contact with the contact surface. In this manner, the manipulator is an electrothermal manipulator, with changes in temperature providing a contact force to pick-up a transferable layer material and a release force to facilitate release of the transferable from the manipulator.
FILED Tuesday, August 31, 2021
APPL NO 17/462862
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 7/00 (20130101)
B25J 11/0095 (20130101)
B25J 15/008 (20130101) Original (OR) Class
B25J 19/0025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064012 Gounder et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
ASSIGNEE(S) PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana)
INVENTOR(S) Rajamani Gounder (West Lafayette, Indiana);  Claire Townsend Nimlos (Lakewood, Colorado);  Byung Jin Lee (SEOUL, South Korea)
ABSTRACT An oligomerization catalyst, oligomer products, methods for making and using same. The catalyst is synthesized MFI zeolite (ZSM-5) made from a combination of DABCO and methylamine (MEA) in the presence of Na cations.
FILED Tuesday, August 31, 2021
APPL NO 17/462597
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 39/48 (20130101) Original (OR) Class

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2006/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064028 Mauter et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Meagan S. Mauter (Palo Alto, California);  Shiqiang Zou (Auburn, Alabama)
ABSTRACT Methods for selenium removal from wastewater are provided using direct electrochemical reduction. Advantageously, the technique can efficiently and continuously treat weakly acidic wastewater (pH 4-7) with 0.001-10 mM Se(IV) concentrations in a weakly acidic solution. Embodiments of the invention include Se(IV) electrochemically removed from the aqueous phase through either a four- or six-electron pathway, with the former generating Se(0) directly attached to the electrode surface and the latter producing Se(-II) that is subsequently converted to Se(0). A key feature of these embodiments is the use of moderate heating to ensure the process takes place at an elevated temperature (e.g., temperatures above the amorphous-to-crystalline transition for Se(0)), which the inventors discovered results in the creation of conductive crystalline Se on an electrode surface, thereby avoiding self-limiting nature of prior techniques which result in insulative amorphous deposition of Se(0) on the electrode.
FILED Monday, August 30, 2021
APPL NO 17/461478
CURRENT CPC
Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/4691 (20130101) Original (OR) Class
C02F 2101/106 (20130101)
C02F 2209/02 (20130101)
C02F 2209/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064066 Sant et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) The Regents of the University of California (Oakland, California);  Yara International ASA (Oslo, Norway);  BASF Corporation (Beachwood, Ohio)
ASSIGNEE(S) The Regents of the University of California (Oakland, California);  Yara International ASA (Oslo, Norway);  BASF Corporation (Beachwood, Ohio)
INVENTOR(S) Gaurav Sant (Los Angeles, California);  Gabriel Falzone (Los Angeles, California);  Tandre Oey (Los Angeles, California);  Wolfram Franke (Los Angeles, California);  Paul Seiler (Los Angeles, California);  Erika La Plante (Los Angeles, California)
ABSTRACT A manufacturing method includes: (1) incorporating at least one soluble, calcium, magnesium, or other divalent cation-containing additive into a concrete mixture including aggregates prone to alkali-silica reaction; and (2) curing the concrete mixture to form a concrete product.
FILED Tuesday, November 16, 2021
APPL NO 17/527948
CURRENT CPC
Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone
C04B 14/06 (20130101)
C04B 14/22 (20130101)
C04B 20/1074 (20130101)
C04B 22/085 (20130101) Original (OR) Class
C04B 22/124 (20130101)
C04B 28/02 (20130101)
C04B 2103/603 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064202 Pemberton et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S) Arizona Board of Regents on behalf of the University of Arizona (Tucson, Arizona)
INVENTOR(S) Jeanne E. Pemberton (Tucson, Arizona);  Bhushan Deodhar (Tucson, Arizona)
ABSTRACT The present invention provides ionic liquids (ILs) comprising a carbohydrate anionic moiety and a cationic counter-ion moiety (Q+) and methods for producing and using the same. In one particular embodiment, the carbohydrate anionic moiety portion of ILs of the present invention is of the formula: (I) wherein G is selected from the group consisting of a monosaccharide, a disaccharide, a trisaccharide, and a derivative thereof; and L is a moiety selected from the group consisting of: (IIA) (IIB) wherein each of Ra, Rb, and Rc is independently hydrogen, C1-18 alkyl, or C2-20 mono- or di-unsaturated alkenyl; ATM is —CO2TM, —PO3HTM, or —SO3TM; and each of * marked carbon atom is independently a chiral center when said carbon atom has four different groups attached thereto.
FILED Sunday, February 09, 2020
APPL NO 17/429346
CURRENT CPC
Separation
B01D 53/1493 (20130101)
B01D 2252/30 (20130101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 3/04 (20130101)
C07H 3/06 (20130101) Original (OR) Class

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 8/144 (20130101)
H01M 2300/0002 (20130101)
H01M 2300/0028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064227 Ercek et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Danielle Tullman Ercek (Wilmette, Illinois);  Lisa A. Burdette (Evanston, Illinois);  Han Teng Wong (Evanston, Illinois)
ABSTRACT The present disclosure provides a recombinant Salmonella strain having a Type III secretion system (T3SS) comprising mutation which enhance protein expression and production. Additionally, methods and kits for using the recombinant Salmonella strain for producing a protein of interest are provided. Additionally, an optimized medium that increases protein expression in a Salmonella strain having a Type III secretion system (T3SS) is provided.
FILED Thursday, January 16, 2020
APPL NO 17/310094
CURRENT CPC
Peptides
C07K 14/255 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/20 (20130101)
C12N 15/74 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 21/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064431 Bailey et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Colorado State University Research Foundation (Fort Collins, Colorado)
ASSIGNEE(S) Colorado State University Research Foundation (Fort Collins, Colorado)
INVENTOR(S) Travis S. Bailey (Fort Collins, Colorado);  Allee S. Klug (Loveland, Colorado)
ABSTRACT The present disclosure relates to triblock and pentablock copolymers and methods of making thereof. Aspects of the disclosure further relate to block copolymer hydrogels that exhibit both fatigue resistance and fracture resistance with superior rates of recovery.
FILED Wednesday, August 25, 2021
APPL NO 17/445910
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 13/0065 (20130101)

Compositions of Macromolecular Compounds
C08L 25/06 (20130101)
C08L 53/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064531 Caram et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Justin Caram (Los Angeles, California);  Stephanie Tenney (Los Angeles, California)
ABSTRACT Many embodiments implement quantum confined nanoplatelets (NPLs) that can be induced to emit bright and tunable infrared emission from attached quantum dot (QD). Some embodiments provide mesoscale NPLs with a largest dimension of greater than 1 micron. Certain embodiments provide methods for growing mesoscale NPLs and QD on mesoscale NPLs heterostructures. Several embodiments provide near unity energy transfer from NPLs to QDs, which can quench NPL emission and emit with high quantum yield through the shortwave infrared. The QD defect emission can be kinetically tunable, enabling controlled mid-gap emission from NPLs.
FILED Thursday, September 02, 2021
APPL NO 17/465444
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 20/00 (20130101)

Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 11/00 (20130101)
C01G 13/00 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/883 (20130101)
C09K 11/892 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064624 NOREN et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) UNIVERSITY OF WYOMING (Laramie, Wyoming)
ASSIGNEE(S)
INVENTOR(S) Benjamin NOREN (Laramie, Wyoming);  John OAKEY (Laramie, Wyoming);  Zhongliang JIANG (Laramie, Wyoming);  Kun JIANG (Laramie, Wyoming)
ABSTRACT Embodiments of the present disclosure generally relate to compositions that include hydrogel-encapsulated/dispersed cells, compositions including hydrogel-encapsulated/dispersed cells, and to processes for forming such hydrogel-encapsulated/dispersed cells and compositions thereof. The compositions can be used for, e.g., therapeutic applications. In some examples, the hydrogel-encapsulated/dispersed cells are formed using photoreactive groups chemically attached to polyethylene glycol to form a material which, upon exposure to a desired wavelength or wavelength range of light, reacts to form a cross-linked hydrogel network.
FILED Tuesday, August 31, 2021
APPL NO 17/463362
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 11/087 (20200101)
C12N 11/089 (20200101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064629 Daugherty et al.
FUNDED BY
National Science Foundation (NSF)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Patrick Sean Daugherty (Santa Barbara, California);  Kevin Todd Boulware (Atlanta, Georgia)
ABSTRACT The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme.
FILED Monday, April 12, 2021
APPL NO 17/227738
CURRENT CPC
Peptides
C07K 14/245 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1037 (20130101)
C12N 15/1044 (20130101) Original (OR) Class

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/37 (20130101)

Combinatorial Chemistry; Libraries, e.g Chemical Libraries
C40B 30/04 (20130101)
C40B 40/02 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6486 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064699 Xuan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
INVENTOR(S) Feng Xuan (Cambridge, Massachusetts);  Peng Yin (Cambrige, Massachusetts);  Mingjie Dai (Cambrige, Massachusetts);  Xi Chen (Cambridge, Massachusetts)
ABSTRACT The present disclosure provides, in some embodiments, methods and compositions for single-molecule detection.
FILED Wednesday, November 10, 2021
APPL NO 17/523611
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6804 (20130101) Original (OR) Class

Combinatorial Chemistry; Libraries, e.g Chemical Libraries
C40B 70/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065926 Chakrabarty et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Krishnendu Chakrabarty (Durham, North Carolina);  Arjun Chaudhuri (Durham, North Carolina)
ABSTRACT A method for identifying observation points for integrated circuit (IC) testing includes receiving a netlist for an IC that includes a first subcircuit and a second subcircuit; determining, from the netlist, one or more observation points, each determined observation point corresponding to an output node which provides observability, into at least the first subcircuit, of an effective number of gates above a specified threshold; and inserting a design for test element into a layout file of the IC at each determined observation point. Observation points can be determined by transforming the netlist into a node graph; assigning a same initial value to a value field of each node; and propagating values in the value fields of the nodes until all nodes with a succeeding edge have a value of zero in their value fields.
FILED Tuesday, August 24, 2021
APPL NO 17/410654
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/3177 (20130101) Original (OR) Class

Electric Digital Data Processing
G06F 30/327 (20200101)
G06F 30/392 (20200101)
G06F 2119/02 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220066189 Yakovlev
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) The Texas A and M University System (College Station, Texas)
ASSIGNEE(S)
INVENTOR(S) Vladislav V. Yakovlev (College Station, Texas)
ABSTRACT A spectroscopy device includes an incoherent light source, tunable to a predetermined emission wavelength; a microscope platform comprising a microscope objective comprising a deep-UV optimized objective and a focal plane defined thereon; a notch filter having an absorption frequency matched to the emission wavelength; and a frequency-selective optical path from the wide-field UV light source to the microscope platform onto the focal plane and from the focal plane through the notch filter.
FILED Friday, May 21, 2021
APPL NO 17/326576
CURRENT CPC
Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry
G01J 3/2823 (20130101)

Optical Elements, Systems, or Apparatus
G02B 21/08 (20130101)
G02B 21/16 (20130101) Original (OR) Class
G02B 21/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067249 Steingrimsson
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S) Baldur Andrew Steingrimsson (Wilsonville, Oregon)
ASSIGNEE(S) Imagars LLC (Wilsonville, Oregon)
INVENTOR(S) Baldur Andrew Steingrimsson (Portland, Oregon)
ABSTRACT This invention presents an innovative framework for the application of machine learning (ML) for identification of energetic materials with desired properties of interest. For the output properties of interest, we identify the corresponding driving (input) factors. We present a framework for a generic engine for predicting properties of energetic materials, once capable of interacting with and receiving support from physics-based prediction models, supporting joint optimization, accounting for properties both at macro- and micro-level, supporting multi-linear regression of descriptors, and offering physics-based interpretation of the descriptors. We present an approach for formulating descriptors, capable of both capturing properties and behavior of complex molecular structures, and that can be imported into ML algorithms for analysis. We show how combustion temperature and density can be analytically accounted for in a hybrid ML and physics-based model for optimizing a specific impulse, for purpose of making the most of the usually limited input data available.
FILED Saturday, October 09, 2021
APPL NO 17/497900
CURRENT CPC
Electric Digital Data Processing
G06F 30/27 (20200101) Original (OR) Class
G06F 30/28 (20200101)
G06F 2111/04 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067442 Masse et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
National Institute of Mental Health (NIMH)
National Science Foundation (NSF)
Directorate for Social, Behavioral and Economic Sciences (SBE)
Division of Behavioral and Cognitive Sciences (BCS)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S) The University of Chicago (Chicago, Illinois)
INVENTOR(S) Nicolas Y. Masse (Chicago, Illinois);  Gregory D. Grant (Chicago, Illinois);  David J. Freedman (Chicago, Illinois)
ABSTRACT A computing device may receive a first set of training data for training an ANN to predict output data for a first task, and may train the ANN with the first set of training data by only adjusting values of weights associated with a first subset of neurons, the first subset selected based on an identity of the first task. The computing device may receive a second, different set of training data for training the ANN to predict output data for a second task, and may train the ANN with the second set of training data by only adjusting values of weights associated with a second subset of neurons, the second subset selected based on an identity of the second task. During training, adjusting of the value of any weight may entail weight stabilization that depends on whether there has been any training for one or more previous tasks.
FILED Thursday, November 11, 2021
APPL NO 17/524338
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6228 (20130101)
G06K 9/6257 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067453 Farhadi et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) Mohammad Farhadi (Tempe, Arizona);  Yezhou Yang (Phoenix, Arizona)
ASSIGNEE(S) Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona)
INVENTOR(S) Mohammad Farhadi (Tempe, Arizona);  Yezhou Yang (Phoenix, Arizona)
ABSTRACT Adaptive and hierarchical convolutional neural networks (AH-CNNs) using partial reconfiguration on a field-programmable gate array (FPGA) are provided. An AH-CNN is implemented to adaptively switch between shallow and deep networks to reach a higher throughput on resource-constrained devices, such as a multiprocessor system on a chip (MPSoC) with a central processing unit (CPU) and FPGA. To this end, the AH-CNN includes a novel CNN architecture having three parts: 1) a shallow part which is a light-weight CNN model, 2) a decision layer which evaluates the shallow part's performance and makes a decision whether deeper processing would be beneficial, and 3) one or more deep parts which are deep CNNs with a high inference accuracy.
FILED Wednesday, September 01, 2021
APPL NO 17/464069
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6232 (20130101)
G06K 9/6267 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 3/0454 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067953 Zimmerman
FUNDED BY
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)
INVENTOR(S) Thomas Guthrie Zimmerman (Cupertino, California)
ABSTRACT A single camera can be used to determine a height of an object. The camera captures an image of the object against a reflective surface backdrop. The distance from the camera and the reflective surface, combined with the distance between the object and the reflection of the object, can be used to determine the distance from the object and the reflective surface.
FILED Wednesday, September 02, 2020
APPL NO 17/010102
CURRENT CPC
Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours
G01B 11/022 (20130101)
G01B 11/026 (20130101)

Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry
G01C 3/08 (20130101)

Image Data Processing or Generation, in General
G06T 7/62 (20170101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068306 Singer et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio)
ASSIGNEE(S)
INVENTOR(S) Kenneth D. Singer (Pepper Pike, Ohio);  Irina Shiyanovskaya (Cleveland, Ohio)
ABSTRACT An optical information storage medium includes a substrate and a multilayer polymeric film. The multilayer polymeric film has a first surface and an opposite second surface that extend the length of the multilayer polymeric film. The second surface is adhered to a surface of the substrate. The multilayer polymeric film includes a plurality of coextruded alternating polymeric active data storage layers and polymeric buffer layers.
FILED Thursday, November 11, 2021
APPL NO 17/524227
CURRENT CPC
Information Storage Based on Relative Movement Between Record Carrier and Transducer
G11B 7/26 (20130101)
G11B 7/0052 (20130101)
G11B 7/0079 (20130101)
G11B 7/242 (20130101)
G11B 7/245 (20130101)
G11B 7/24027 (20130101)
G11B 7/24038 (20130101) Original (OR) Class
G11B 7/24044 (20130101)
G11B 7/24056 (20130101)
G11B 7/24065 (20130101)
G11B 2007/0013 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068482 Zimmerman et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Information and Intelligent Systems (IIS)
APPLICANT(S) Carnegie Mellon University (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) John Zimmerman (Pittsburgh, Pennsylvania);  Adam Perer (Pittsburgh, Pennsylvania);  Lisa C. Lohmueller (Pittsburgh, Pennsylvania)
ABSTRACT Systems and methods for treating a patient for a medical condition using an interactive treatment pathway interface associated with the medical condition include receiving, through an interface, patient data representing a medical status of a patient. Treatment pathway data representing a sequence of actions for a particular treatment or diagnosis of a medical condition of the patient are retrieved. The interface guides the particular treatment or diagnosis of the medical condition by a traversal of the treatment pathway. A data trace is generated from additional patient data received during the traversal. The represents the instance of the particular treatment or diagnosis of the medical condition of the patient. The data are used to affect the particular treatment or diagnosis for the medical condition to the patient and inform machine learning operations for diagnosis or treatment of the medical condition.
FILED Friday, February 28, 2020
APPL NO 17/435431
CURRENT CPC
Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/60 (20180101)
G16H 20/00 (20180101)
G16H 50/20 (20180101) Original (OR) Class
G16H 70/20 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220068495 Spilker et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computing and Communication Foundations (CCF)
APPLICANT(S) The Board of Trustees of Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S) The Board of Trustees of Leland Stanford Junior University (, None)
INVENTOR(S) Ryan Leonard Spilker (Arlington, Massachusetts);  Charles Anthony Taylor, JR. (Atherton, California)
ABSTRACT Computational methods are used to create cardiovascular simulations having desired hemodynamic features. Cardiovascular modeling methods produce descriptions of blood flow and pressure in the heart and vascular networks. Numerical methods optimize and solve nonlinear equations to find parameter values that result in desired hemodynamic characteristics including related flow and pressure at various locations in the cardiovascular system, movements of soft tissues, and changes for different physiological states. The modeling methods employ simplified models to approximate the behavior of more complex models with the goal of to reducing computational expense. The user describes the desired features of the final cardiovascular simulation and provides minimal input, and the system automates the search for the final patient-specific cardiovascular model.
FILED Thursday, August 05, 2021
APPL NO 17/394591
CURRENT CPC
Electric Digital Data Processing
G06F 30/20 (20200101)
G06F 2111/10 (20200101)

Image Data Processing or Generation, in General
G06T 17/20 (20130101)
G06T 19/20 (20130101)
G06T 2210/24 (20130101)
G06T 2210/41 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/60 (20180101)
G16H 30/40 (20180101)
G16H 50/50 (20180101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069349 KOTOV et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
INVENTOR(S) Nicholas A. KOTOV (Ypsilanti, Michigan);  Mingqiang WANG (Harbin, China PRC);  Ahmet Emrehan EMRE (Ann Arbor, Michigan)
ABSTRACT A composite solid electrolyte for a solid-state electrochemical cell is provided. The electrolyte may include a plurality of aramid nanofibers, such as a branched aramid nanofiber network, an ionically conductive polymer, such as poly(ethylene oxide) or quaternary ammonia functionalized polyvinyl alcohol (QAFPVA), and an optional divalent ion salt. The electrolyte is particularly suitable for use with zinc ions, where the divalent ion salt may comprise zinc trifluoromethanesulfonate Zn(CF3SO3)2 An electrochemical cell or battery is provided incorporating such a composite solid electrolyte that cycles ions, such as zinc ions or hydroxide ions, suppresses or minimizes dendrite formation, while having good ionic conductivity and being flexible. This flexibility provides the ability to create deformations in the electrochemical cell, such as protrusions and recesses that may define a corrugated pattern. Such a battery may be a rechargeable structural battery with a corrugated surface profile that can be used to form load-bearing structural components.
FILED Monday, January 06, 2020
APPL NO 17/420331
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/502 (20130101)
H01M 10/0565 (20130101) Original (OR) Class
H01M 12/08 (20130101)
H01M 2300/0082 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220071003 WANG et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Joseph WANG (San Diego, California);  Rajan Kumar (La Jolla, California);  Ying Shirley Meng (San Diego, California);  Jae Wook Shin (La Jolla, California);  Lu Yin (San Diego, California)
ABSTRACT Disclosed are compositions, devices, systems and fabrication methods for stretchable composite materials and stretchable electronics devices. In some aspects, an elastic composite material for a stretchable electronics device includes a first material having a particular electrical, mechanical or optical property; and a multi-block copolymer configured to form a hyperelastic binder that creates contact between the first material and the multi-block copolymer, in which the elastic composite material is structured to stretch at least 500% in at least one direction of the material and to exhibit the particular electrical, mechanical or optical property imparted from the first material. In some aspects, the stretchable electronics device includes a stretchable battery, biofuel cell, sensor, supercapacitor or other device able to be mounted to skin, clothing or other surface of a user or object.
FILED Wednesday, October 13, 2021
APPL NO 17/500931
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/1477 (20130101)
A61B 5/14865 (20130101)

Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 297/046 (20130101)

Compositions of Macromolecular Compounds
C08L 53/02 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/38 (20130101)
H01M 4/48 (20130101)
H01M 4/622 (20130101)
H01M 4/663 (20130101)
H01M 4/666 (20130101)
H01M 4/668 (20130101)
H01M 10/24 (20130101)

Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 1/16 (20130101)
H05K 1/028 (20130101)
H05K 1/118 (20130101)
H05K 1/0283 (20130101) Original (OR) Class
H05K 1/0393 (20130101)
H05K 3/326 (20130101)
H05K 2201/0133 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 20220061236 Guan et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S) Kaiyu Guan (Champaign, Illinois);  Bin Peng (Urbana, Illinois);  Chongya Jiang (Urbana, Illinois);  Wang Zhou (Urbana, Illinois);  Jingwen Zhang (Urbana, Illinois);  Yizhi Huang (Champaign, Illinois);  Jian Peng (Champaign, Illinois);  Sibo Wang (Champaign, Illinois)
ABSTRACT An integrated multi-scale modeling platform is utilized to assess agricultural productivity and sustainability. The model is used to assess the environmental impacts of agricultural management from individual fields to watershed/basin to continental scales. In addition, an integrated irrigation system is developed using data and a machine-learning model that includes weather forecast and soil moisture simulation to determine an irrigation amount for farmers. Next, crop cover classification prediction can be established for an ongoing growing system using a machine learning or statistical model to predict the planted crop type in an area. Finally, a method of predicting key phenology dates of crops for individual field parcels, farms, or parts of a field parcel, in a growing season, can be established.
FILED Wednesday, August 25, 2021
APPL NO 17/445928
CURRENT CPC
Soil Working in Agriculture or Forestry; Parts, Details, or Accessories of Agricultural Machines or Implements, in General
A01B 79/005 (20130101)

Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering
A01G 25/16 (20130101) Original (OR) Class

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062407 Chowdhury
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Shafiqul I. Chowdhury (Baton Rouge, Louisiana)
ASSIGNEE(S) BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHAN (Baton Rouge, Louisiana)
INVENTOR(S) Shafiqul I. Chowdhury (Baton Rouge, Louisiana)
ABSTRACT The application describes recombinant BoHV-1 triple mutant viruses that express protective antigens of other bovine respiratory viruses associated with Bovine respiratory disease complex (BRDC).
FILED Friday, July 09, 2021
APPL NO 17/372044
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/12 (20130101)
A61K 39/39 (20130101)
A61K 39/245 (20130101) Original (OR) Class
A61K 2039/543 (20130101)

Peptides
C07K 14/005 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064664 Bent et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin);  The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S) Andrew Bent (Madison, Wisconsin);  Matthew Hudson (Urbana, Illinois);  Brian Diers (Urbana, Illinois);  Sara Melito (Sassari, Italy);  David Cook (Madison, Wisconsin);  Teresa Hughes (Lafayette, Indiana);  Adam Bayless (Madison, Wisconsin);  Jianping Wang (Gainesville, Florida);  Tong Geon Lee (Champaign, Illinois);  Xiaoli Guo (Madison, Wisconsin)
ABSTRACT Methods of increasing the resistance of plants, in particular soybeans, to nematodes, in particular soybean cyst nematodes, are provided herein. The methods include increasing the expression of Glyma18g02580, Glyma18g02590 and/or Glyma18g2610 in cells of a plant and in particular in root cells of a plant to increase the resistance of the plant and plant cells to nematodes. The methods include increasing the expression using constitutive promoters or by increasing the copy number of the polynucleotides. Constructs for expressing these polypeptides, transgenic cells, transgenic plants and methods of generating the same are also provided. Methods of screening plant cells for resistance or susceptibility to nematodes are also provided.
FILED Monday, May 03, 2021
APPL NO 17/246903
CURRENT CPC
New Plants or Processes for Obtaining Them; Plant Reproduction by Tissue Culture Techniques
A01H 5/10 (20130101)
A01H 6/542 (20180501)

Peptides
C07K 14/415 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/8285 (20130101) Original (OR) Class

Technologies for Adaptation to Climate Change
Y02A 40/146 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064678 DEMIRCI et al.
FUNDED BY
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) The Penn State Research Foundation (University Park, Pennsylvania);  UNIVERSITY OF WAIKATO (Hillcrest, New Zealand)
ASSIGNEE(S)
INVENTOR(S) Ali DEMIRCI (Port Matilda, Pennsylvania);  Ehsan MAHDINIA (Albany, New York);  Aydin BERENJIAN (Hamilton East, New Zealand)
ABSTRACT Provided are improved methods for Vitamin K, including but not necessarily limited to MK-7 production through bacterial fermentation using biofilm reactors. Fed-batch addition of carbon sources, such as glucose, are used as the base media in biofilm reactors. Fed-batch strategies are shown to be significantly effective in glucose-based medium, increasing the end-product concentrations to more than 2-fold higher than the level produced in suspended-cell bioreactors.
FILED Tuesday, December 10, 2019
APPL NO 17/312673
CURRENT CPC
Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/66 (20130101) Original (OR) Class

Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms
C12R 2001/125 (20210501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067336 Fuentes Ponce et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) Board of Trustees of the University of Arkansas (Little Rock, Arkansas);  The United States of America, as represented by The Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S) Board of Trustees of the University of Arkansas (Little Rock, Arkansas);  The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia)
INVENTOR(S) Bryan Andre Fuentes Ponce (Fayetteville, Arkansas);  Phillip Ray Owens (Fayetteville, Arkansas);  Minerva Justine Dorantes (Fayetteville, Arkansas)
ABSTRACT An integrative computational soil mapping system and process that reduces the required number of soil property measurements without jeopardizing the statistical precision of the resulting digital soil maps. The integrative computational soil mapping system and process saves monetary resources and time by reducing the number of soil property measurements required to produce digital soil maps and by offering soil sample locations which capture the maximum amount of representativeness of the soil characteristics in a determined area. In addition, the inventive system and process are integrative computational soil mapping that utilize algorithms based on state-of-the-art computational statistics and machine learning methods for the production of digital soil property maps and also provides soil sampling locations to collect new soil property measurements. These soil property measurements can be used to update and potentially improve previous versions of digital soil property maps, produced by the computational process.
FILED Monday, August 30, 2021
APPL NO 17/461281
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/0063 (20130101) Original (OR) Class
G06K 9/6218 (20130101)
G06K 9/6232 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067614 Guan et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S) Kaiyu Guan (Champaign, Illinois);  Jian Peng (Champaign, Illinois);  Xiangtao Xu (Arlington, Massachusetts);  Sibo Wang (Champaign, Illinois);  Bin Peng (Savoy, Illinois)
ABSTRACT Aspects of the subject disclosure may include, for example, a device comprising: a processing system including a processor; and a memory that stores executable instructions that, when executed by the processing system, perform operations, the operations comprising: identifying an occurrence of one or multiple phenology stages of a crop, resulting in identified occurrences; optimizing, based upon the identified occurrences, a yield model, wherein the yield model produces, after the optimizing, a first predicted yield for a first region; and generating a second predicted yield based upon the first predicted yield, wherein the second predicted yield covers a second region that is smaller than the first region. Additional embodiments are disclosed.
FILED Wednesday, December 18, 2019
APPL NO 17/415598
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00657 (20130101)
G06K 2009/00644 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/04 (20130101)
G06Q 10/06315 (20130101) Original (OR) Class
G06Q 50/02 (20130101)

Image Data Processing or Generation, in General
G06T 7/97 (20170101)
G06T 2207/10036 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 20220065318 Petschow et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
ASSIGNEE(S) HONEYWELL INTERNATIONAL INC. (Morris Plains, New Jersey)
INVENTOR(S) Daniel Petschow (Gilbert, Arizona);  Stephen Abel (Chandler, Arizona);  Kevin Gardner (Tempe, Arizona)
ABSTRACT In exemplary embodiments, a caged spring assembly is provided that includes a first end cap, a second end cap, a helical spring, and a locking post. The second end cap is opposite the first end cap. The helical spring extends between the first and second end caps. The locking post is disposed inside the helical spring between the first and second end caps. The locking post allows limited compression of the helical spring and prevents extension of the helical spring beyond a set point.
FILED Friday, August 28, 2020
APPL NO 17/006372
CURRENT CPC
Springs; Shock-absorbers; Means for Damping Vibration
F16F 1/122 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067614 Guan et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S) Kaiyu Guan (Champaign, Illinois);  Jian Peng (Champaign, Illinois);  Xiangtao Xu (Arlington, Massachusetts);  Sibo Wang (Champaign, Illinois);  Bin Peng (Savoy, Illinois)
ABSTRACT Aspects of the subject disclosure may include, for example, a device comprising: a processing system including a processor; and a memory that stores executable instructions that, when executed by the processing system, perform operations, the operations comprising: identifying an occurrence of one or multiple phenology stages of a crop, resulting in identified occurrences; optimizing, based upon the identified occurrences, a yield model, wherein the yield model produces, after the optimizing, a first predicted yield for a first region; and generating a second predicted yield based upon the first predicted yield, wherein the second predicted yield covers a second region that is smaller than the first region. Additional embodiments are disclosed.
FILED Wednesday, December 18, 2019
APPL NO 17/415598
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00657 (20130101)
G06K 2009/00644 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/04 (20130101)
G06Q 10/06315 (20130101) Original (OR) Class
G06Q 50/02 (20130101)

Image Data Processing or Generation, in General
G06T 7/97 (20170101)
G06T 2207/10036 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220067863 Sheth et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
APPLICANT(S) United States of America as Represented by the Administrator of NASA (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Kapil S. Sheth (Campbell, California);  Parimal Hemchandra Kopardekar (Cupertino, California)
ABSTRACT Identifying geographical locations suitable for a vertiport. Suitability factors across a geographical area are identified for consideration including, without limitation, noise, zoning, transit stations, fire stations, and hospitals. The suitability factors have suitability values that are based on characteristics, including location-based suitability values (i.e., proximity to mass transit stations), level-based suitability values (i.e., noise levels), and characteristic-based suitability values (i.e., residential zoning). The vertiport assessment system divides the geographical area into subregions, identifies a set of candidate vertiport locations using suitability values, weights for scaling the impact of the suitability factor, and identifies a particular subregion as a candidate location if a composite value exceeds a threshold value. The candidate subregions are shown on a user interface map overlay in a color-coded gradient that reflects the composite values for a subregion. These candidate vertiport locations are refined by establishing feasibility of flight between them.
FILED Wednesday, December 23, 2020
APPL NO 17/133424
CURRENT CPC
Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/06315 (20130101)
G06Q 30/018 (20130101)
G06Q 30/0205 (20130101)
G06Q 50/26 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069475 Patriotis et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
APPLICANT(S) Marios Patriotis (Albuquerque, New Mexico);  Christos G. Christodoulou (Albuquerque, New Mexico);  Sudharman Jayaweera (Albuquerque, New Mexico);  Firas Nazem Ayoub (Albuquerque, New Mexico)
ASSIGNEE(S) UNM Rainforest Innovations (Albuquerque, New Mexico);  BlueCom Systems and Consulting, LLC (Albuquerque, New Mexico)
INVENTOR(S) Marios Patriotis (Albuquerque, New Mexico);  Christos G. Christodoulou (Albuquerque, New Mexico);  Sudharman Jayaweera (Albuquerque, New Mexico);  Firas Nazem Ayoub (Albuquerque, New Mexico)
ABSTRACT A circularly polarized antenna having a plurality of arrays. The arrays comprised of a plurality of antenna elements which are consecutively orthogonal to each other.
FILED Friday, December 13, 2019
APPL NO 17/416462
CURRENT CPC
Antennas, i.e Radio Aerials
H01Q 21/0006 (20130101) Original (OR) Class
H01Q 21/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220069645 Cantemir et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Glenn Research Center (GLENN)
NASA Shared Services Center (NSSC)
APPLICANT(S) Olivia Bruj (, None);  Ohio State Innovation Foundation (Columbus, Ohio)
ASSIGNEE(S)
INVENTOR(S) Codrin Cantemir (Columbus, Ohio);  Olivia Bruj (Cluj, Romania)
ABSTRACT Improved electric machines with tuned coils, integrated power electronics, and stator and rotor cooling assemblies.
FILED Monday, August 30, 2021
APPL NO 17/461956
CURRENT CPC
Dynamo-electric Machines
H02K 1/20 (20130101) Original (OR) Class
H02K 1/165 (20130101)
H02K 3/12 (20130101)
H02K 3/24 (20130101)
H02K 3/28 (20130101)
H02K 3/48 (20130101)
H02K 5/203 (20210101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 20220061831 Byju et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) The Texas A and M University System (College Station, Texas);  Baylor College of Medicine (Houston, Texas);  Fannin Partners, LLC (Houston, Texas)
ASSIGNEE(S) The Texas A and M University System (College Station, Texas);  Baylor College of Medicine (Houston, Texas);  Fannin Partners, LLC (Houston, Texas)
INVENTOR(S) Achu Geetha Byju (College Station, Texas);  Balakrishna Haridas (College Station, Texas);  Jimmy Espinoza (Houston, Texas);  Michael J. Belfort (Houston, Texas);  Michael J. Heffernan (Katy, Texas)
ABSTRACT An approximating anchor device, corresponding kits, and methods for implementing the device are described herein. In one embodiment, the approximating anchor device includes a first cylindrical fastener defining a first set of cross lumens, each of the first set of cross lumens extending substantially perpendicular to a central axis of the first cylindrical fastener, a second cylindrical fastener defining a second set of cross lumens, each of the second set of cross lumens extending substantially perpendicular to a central axis of the second cylindrical fastener, and a string running through the first set of cross lumens of the first cylindrical fastener and the second set of cross lumens of the second cylindrical fastener. Tightening of the string will draw the first cylindrical fastener and the second cylindrical fastener towards each other.
FILED Friday, January 03, 2020
APPL NO 17/420212
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 1/3132 (20130101)
A61B 17/0401 (20130101) Original (OR) Class
A61B 2017/4216 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220062959 Campanella et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Loci Controls, Inc. (Wareham, Massachusetts)
ASSIGNEE(S) Loci Controls, Inc. (Wareham, Massachusetts)
INVENTOR(S) Andrew Campanella (Somerville, Massachusetts);  Joseph G. Michels (New York, New York);  Peter Quigley (Duxbury, Massachusetts);  Ian Martin (Sharon, Massachusetts)
ABSTRACT A control system for controlling extraction of landfill gas, comprising: at least one sensor configured to measure one or more characteristics of landfill gas; at least one flow control mechanism disposed in well piping and configured to control flow of the landfill gas through the well piping; and at least one processor configured to: obtain a measured concentration of a first gas in landfill gas; determine whether the measured concentration of the first gas is either less than a first threshold concentration or greater than a second threshold concentration; when it is determined that the measured concentration is less than the first threshold concentration, control the at least one flow control mechanism to reduce flow rate of landfill gas; and when it is determined that the concentration is greater than the second threshold concentration, control the at least one flow control mechanism to increase the flow rate of landfill gas.
FILED Wednesday, July 07, 2021
APPL NO 17/369318
CURRENT CPC
Disposal of Solid Waste
B09B 1/006 (20130101) Original (OR) Class

Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells
E21B 43/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220065912 KELLER, III et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Sea Systems Command (NAVSEA)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) NOKOMIS, INC (Charleroi, Pennsylvania)
ASSIGNEE(S) NOKOMIS, INC (Charleroi, Pennsylvania)
INVENTOR(S) Walter John KELLER, III (Bridgeville, Pennsylvania);  Andrew Richard PORTUNE (Oakdale, Pennsylvania);  Todd Eric CHORNENKY (Carmichaels, Pennsylvania);  William Anthony DAVIS (Perrysburg, Ohio)
ABSTRACT An apparatus for detecting a condition or authenticity of one or more electronic devices includes an enclosure having an antenna integrated therewithin, a fixture mounted within a hollow interior of the enclosure, the fixture being configured to receive the one or more electronic devices and connect one or more signals to each of the one or more electronic devices and a sensor and controller assembly connected to the antenna and configured to process a signature of an emission of a radiofrequency (RF) energy from of one or more electronic devices having the one or more signals connected thereto.
FILED Monday, April 26, 2021
APPL NO 17/240081
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 31/002 (20130101) Original (OR) Class

Electric Digital Data Processing
G06F 21/73 (20130101)

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 2924/0002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 20220061536 Cooper et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania);  The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Rory Alan Cooper (Gibsonia, Pennsylvania);  Michael A. Shulock (Murrysville, Pennsylvania);  Joshua D. Brown (Pittsburgh, Pennsylvania);  Garrett G. Grindle (Pittsburgh, Pennsylvania);  Benjamin Todd Gebrosky (Gibsonia, Pennsylvania);  Sayeedur Rahman (Issaquah, Washington);  Sivan Almosnino (Snoqualmie, Washington);  Lisa Garamella (Charlotte, North Carolina);  Daniel Robin (Seattle, Washington)
ABSTRACT An access system includes a laterally extending frame, a carriage in operative connection with the laterally extending frame and including a drive to move the carriage laterally on the frame, a seat support attached to the carriage including a seat assembly interface and a lift to raise and lower the seat assembly interface within a range of positions, a seat assembly attached to the seat assembly interface, a controller in operative connection with the drive of the carriage and the lift of the seat support via which the position of the seat support is controllable, and a controller interface in operative connection with the controller.
FILED Tuesday, August 31, 2021
APPL NO 17/462462
CURRENT CPC
Chairs; Sofas; Beds
A47C 1/025 (20130101)
A47C 1/0242 (20130101)
A47C 3/20 (20130101)
A47C 7/62 (20130101) Original (OR) Class
A47C 7/5064 (20180801)

Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices
A61G 5/04 (20130101)
A61G 5/128 (20161101)
A61G 5/1059 (20130101)
A61G 5/1067 (20130101)
A61G 2200/34 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064451 HELGASON et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Office of Research and Development (DVAORD)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Non-Profit Organization (NPO)
Dystrophic Epidermolysis Bullosa Research Association of America (DEBRA of America)
APPLICANT(S) VitroLabs Inc (San Jose, California);  King's College London (London, United Kingdom)
ASSIGNEE(S)
INVENTOR(S) Ingvar HELGASON (San Jose, California);  Dusko ILIC (London, United Kingdom)
ABSTRACT Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.
FILED Friday, July 02, 2021
APPL NO 17/366550
CURRENT CPC
Compositions of Macromolecular Compounds
C08L 89/06 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0625 (20130101)
C12N 5/0629 (20130101)
C12N 5/0698 (20130101)
C12N 11/02 (20130101)
C12N 2501/155 (20130101)
C12N 2501/385 (20130101)
C12N 2502/13 (20130101)
C12N 2502/091 (20130101)
C12N 2502/094 (20130101)
C12N 2506/45 (20130101)
C12N 2533/30 (20130101)
C12N 2533/54 (20130101)

Chemical Treatment of Hides, Skins or Leather, e.g Tanning, Impregnating, Finishing; Apparatus Therefor; Compositions for Tanning
C14C 3/02 (20130101)
C14C 13/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Non-Profit Organization (NPO) 

US 20220062320 WISNIEWSKI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Non-Profit Organization (NPO)
Alzheimer's Disease and Related Disorders Association, Inc. (ADRDA)
APPLICANT(S) NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Thomas WISNIEWSKI (Staten Island, New York);  Daryl SPINNER (Staten Island, New York);  Henrieta SCHOLTZOVA (Fords, New Jersey);  Richard KASCSAK (Morganville, New Jersey)
ABSTRACT The present invention is directed to a method of preventing or reducing amyloid deposition in a subject. This method involves selecting a subject with amyloid deposits and stimulating the innate immune system of the selected subject under conditions effective to reduce the amyloid deposits. Also disclosed is a method of preventing or treating cerebral amyloidosis and Alzheimer's Disease in a subject by administering to the selected subject an agent that stimulates the innate immune system. In addition, a composition useful for the stimulation of the innate immune system of a subject exhibiting symptoms associated with amyloid deposition is disclosed.
FILED Thursday, February 25, 2021
APPL NO 17/184758
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7088 (20130101) Original (OR) Class
A61K 48/00 (20130101)
A61K 2039/57 (20130101)
A61K 2039/545 (20130101)
A61K 2039/55561 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/85 (20130101)
C12N 15/117 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220064451 HELGASON et al.
FUNDED BY
Department of Veterans Affairs (DVA)
Office of Research and Development (DVAORD)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Non-Profit Organization (NPO)
Dystrophic Epidermolysis Bullosa Research Association of America (DEBRA of America)
APPLICANT(S) VitroLabs Inc (San Jose, California);  King's College London (London, United Kingdom)
ASSIGNEE(S)
INVENTOR(S) Ingvar HELGASON (San Jose, California);  Dusko ILIC (London, United Kingdom)
ABSTRACT Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.
FILED Friday, July 02, 2021
APPL NO 17/366550
CURRENT CPC
Compositions of Macromolecular Compounds
C08L 89/06 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0625 (20130101)
C12N 5/0629 (20130101)
C12N 5/0698 (20130101)
C12N 11/02 (20130101)
C12N 2501/155 (20130101)
C12N 2501/385 (20130101)
C12N 2502/13 (20130101)
C12N 2502/091 (20130101)
C12N 2502/094 (20130101)
C12N 2506/45 (20130101)
C12N 2533/30 (20130101)
C12N 2533/54 (20130101)

Chemical Treatment of Hides, Skins or Leather, e.g Tanning, Impregnating, Finishing; Apparatus Therefor; Compositions for Tanning
C14C 3/02 (20130101)
C14C 13/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Commerce (DOC) 

US 20220065675 Brown et al.
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)
INVENTOR(S) Christopher Uriah Brown (Frederick, Maryland);  Gregory William Vogl (Gaithersburg, Maryland);  Wai Cheong Tam (Germantown, Maryland)
ABSTRACT A wireless flow rate apparatus measures flow rate in a fluid-conductive conduit and includes: the fluid conductive conduit comprising a non-rigid wall; a wireless sensor network including a flow sensor that detects vibrations of the fluid-conductive conduit, produces a sensor signal; and a wireless node that receives the sensor signal and wirelessly communicates the sensor signal; a base station that wirelessly receives the sensor signal; and a flow rate analyzer that receives the sensor signal from the base station and determines the flow rate of fluid in the fluid-conductive conduit from the sensor signal.
FILED Thursday, August 19, 2021
APPL NO 17/406187
CURRENT CPC
Fire-fighting
A62C 31/28 (20130101)

Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume
G01F 1/8468 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Nuclear Regulatory Commission (NRC) 

US 20220069361 Surampudi et al.
FUNDED BY
Nuclear Regulatory Commission (NRC)
Center for Nuclear Waste Regulatory Analyses (CNWRA)
Federally Funded Research and Development Center (FFRDC)
Operated by Southwest Research Institute (SWRI) at San Antonio, TX
APPLICANT(S) Southwest Research Institute (San Antonio, Texas)
ASSIGNEE(S)
INVENTOR(S) Bapiraju Surampudi (San Antonio, Texas);  Kevin Jones (San Antonio, Texas)
ABSTRACT A method of controlling the charge current during charging of a lithium-ion battery. A battery charging controller is based on a Kalman filter, which uses estimated battery states to generate a feedback metric to continually adjust a battery cell model. The battery cell model then delivers data to an optimization process that generates the charge current.
FILED Tuesday, August 25, 2020
APPL NO 17/002380
CURRENT CPC
Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 10/425 (20130101) Original (OR) Class
H01M 10/484 (20130101)
H01M 2010/4271 (20130101)
H01M 2220/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Government Rights Acknowledged 

US 20220065950 Cao et al.
FUNDED BY
APPLICANT(S) VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia)
ASSIGNEE(S)
INVENTOR(S) Yuliang Cao (Blacksburg, Virginia);  Minh Ngo (Blacksburg, Virginia);  Dong Dong (Blacksburg, Virginia);  Rolando Burgos (Blacksburg, Virginia)
ABSTRACT Various examples of a high frequency, inductor and transformer core loss characterization and measurement method and system for arbitrary waveforms are disclosed herein. A system and method for determining core loss of a magnetic core can include generating a waveform to excite a first test circuit which comprises an excitation circuit, a circuit under test (CUT) comprising the magnetic core, and an inductance circuit having an inductor connected in parallel to the CUT. The method includes measuring a first current, when the first test circuit is excited. The method includes disconnecting the CUT from the first test circuit to form a second test circuit. The method includes generating the waveform to excite the second test circuit, and measuring a second current, when the second test circuit is excited. The power loss for the magnetic core is calculated based on an input voltage and the first and second measured current.
FILED Friday, August 28, 2020
APPL NO 17/006058
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables