FedInvent™ Patent Applications
Application Details for Thursday, March 24, 2022
This page was updated on Saturday, March 26, 2022 at 04:19 PM GMT
Department of Health and Human Services (HHS)
| US 20220087285 | Guo et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tai L. Guo (Bogart, Georgia); Yingjia Chen (Bogart, Georgia) |
| ABSTRACT | Therefore, disclosed herein is a composition comprising dietary early glycation products (EGPs) with less than 1 wt % advanced glycation end products (AGEs). Also disclosed is a method for treating or preventing diabetes in a subject, such as type 1 diabetes, type 2 diabetes, or gestational diabetes, that involves administering to a subject in need thereof a composition disclosed herein. |
| FILED | Wednesday, January 15, 2020 |
| APPL NO | 17/420411 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 1/20 (20130101) A23J 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087595 | Egorov |
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| FUNDED BY |
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| APPLICANT(S) | Vladimir Egorov (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Egorov (Princeton, New Jersey) |
| ABSTRACT | The Biomechanical Integrity Score and its five components are calculated as a result of vaginal tactile probe insertion, elevation, rotation, Valsalva maneuver, voluntary pelvic muscle contraction, reflex contraction, and relaxation while the probe is in contact with vaginal walls for a comprehensive biomechanical characterization of the pelvic floor. The probe is equipped with a plurality of tactile sensors recording various static and dynamic pressure patterns during a vaginal examination. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526271 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0053 (20130101) A61B 5/4337 (20130101) Original (OR) Class A61B 5/4884 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087651 | Alizad et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azra Alizad (Rochester, Minnesota); Mostafa Fatemi (Rochester, Minnesota); Rohit Nayak (Rochester, Minnesota) |
| ABSTRACT | Described here are systems and methods for generating microvessel images from image data acquired with an ultrasound system while analyzing the image data in realtime, or retrospectively, to generate a performance descriptor that can be used to assess data quality and/or motion correction quality; to adaptively suppress noise in the data; or both. |
| FILED | Monday, January 13, 2020 |
| APPL NO | 17/422384 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/06 (20130101) A61B 8/0891 (20130101) A61B 8/5207 (20130101) Original (OR) Class A61B 8/5223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087813 | BURGE et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania); CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (Madrid, Spain) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Johannes Daniel BURGE (Philadelphia, Pennsylvania); Carlos Dorronsoro DIAZ (Madrid, Spain); Victor Rodriguez LOPEZ (Madrid, Spain) |
| ABSTRACT | Methods, systems, and ophthalmic devices are described for correcting a misperception of depth of a moving object. An example ophthalmic device may comprise a first lens having a first optical characteristic that increases a distance of a focal point of a first eye. The ophthalmic device may comprise a second lens having a second optical characteristic that decreases a distance of a focal point of a second eye. The second lens may have a third optical characteristic that reduces a misperception of a distance of an moving object. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 17/425144 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/1451 (20150401) A61F 2/1621 (20130101) Original (OR) Class Spectacles; Sunglasses or Goggles Insofar as They Have the Same Features as Spectacles; Contact Lenses G02C 7/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087817 | Dasi et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| INVENTOR(S) | Lakshmi Prasad Dasi (Dublin, Ohio); Atieh Yousefi Koupaei (Columbus, Ohio); Megan Kristine Heitkemper (Columbus, Ohio) |
| ABSTRACT | A transcatheter prosthetic heart valve includes a stent frame and at least one sheet of leaflet material formed in to a tube, which includes a lower portion disposed on an exterior of the stent frame and an upper edge portion disposed within the stent frame. The upper edge portion includes at least a portion configured to wrap around a first portion of the top edge of the stent frame and fold towards an exterior of the stent frame. The upper edge portion also includes at least another portion configured to weave through the stent frame and fold towards the interior of the stent frame. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544194 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2415 (20130101) A61F 2/2418 (20130101) Original (OR) Class A61F 2/2433 (20130101) A61F 2210/0004 (20130101) A61F 2240/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087860 | Santa Maria et al. |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Santa Maria (Redwood City, California); Brian Hsueh (Pacifica, California); Brian Kannard (Mountain View, California); Ritu Lal (Palo Alto, California); Abhinav Ramani (Herndon, Virginia); John Paderi (San Francisco, California) |
| ABSTRACT | A method for maintaining and/or increasing body temperature of a patient may involve delivering heat to a first location on a limb of the patient, delivering heat to a second location on the limb, apart from the first location, and applying intermittent compression to a third location on the limb, located between the first location and the second location. A device for maintaining and/or increasing body temperature of a patient may include a sleeve for positioning over at least part of one of the patient's limbs, first and second heat delivery members coupled with the sleeve, and an intermittent compression member coupled with the sleeve between the first and second heat delivery members. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/543442 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 7/02 (20130101) Original (OR) Class Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 9/00 (20130101) A61H 9/005 (20130101) A61H 9/0057 (20130101) A61H 9/0078 (20130101) A61H 9/0092 (20130101) A61H 39/04 (20130101) A61H 2201/02 (20130101) A61H 2201/0103 (20130101) A61H 2201/0184 (20130101) A61H 2230/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087930 | Gambotto et al. |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
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| INVENTOR(S) | Andrea Gambotto (Pittsburgh, Pennsylvania); Louis Falo, JR. (Wexford, Pennsylvania); Eun Kim (Allison Park, Pennsylvania) |
| ABSTRACT | A recombinant coronavirus vaccine is provided. Methods of making and delivering the coronavirus vaccine also are provided. A microneedle array is provided, along with methods of making and using the microneedle array. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/538412 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/150984 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0021 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 47/58 (20170801) A61K 2039/505 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087950 | Chen et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianzhu Chen (Lexington, Massachusetts); Guangan Hu (Westwood, Massachusetts) |
| ABSTRACT | Disclosed are methods of modulating macrophage activation to treat various diseases, such as cancer, fibrosis, infectious diseases, inflammatory diseases, metabolic diseases, or autoimmune diseases. Also disclosed are methods of identifying compounds useful for modulating macrophage activation as means to treat cancer, fibrosis, infectious diseases, inflammatory diseases, metabolic diseases, or autoimmune diseases. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/381857 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/03 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087954 | Harrison et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David G. Harrison (Nashville, Tennessee); David M. Patrick (Nashville, Tennessee) |
| ABSTRACT | The invention relates to compounds, compositions, and methods for the treatment of lupus. The compounds of the present invention are isoLG savaging compounds. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/031642 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/137 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087970 | Johns et al. |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roger A. Johns (Baltimore, Maryland); Michele Schaefer (Baltimore, Maryland) |
| ABSTRACT | Methods for treating or preventing a cognitive impairment in a subject in need of treatment thereof, the method comprising administering to the subject a therapeutically effective amount of an agent that enhances the NO-cGMP-PKG pathway are disclosed. |
| FILED | Saturday, January 18, 2020 |
| APPL NO | 17/421497 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/04 (20130101) A61K 31/34 (20130101) A61K 31/53 (20130101) A61K 31/165 (20130101) A61K 31/197 (20130101) A61K 31/295 (20130101) Original (OR) Class A61K 31/397 (20130101) A61K 31/502 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/555 (20130101) A61K 31/4155 (20130101) A61K 31/4985 (20130101) A61K 31/5377 (20130101) A61K 33/00 (20130101) A61K 38/10 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087977 | PANIGRAHY et al. |
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| FUNDED BY |
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| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dipak PANIGRAHY (Boston, Massachusetts); Allison GARTUNG (Boston, Massachusetts); Anna FISHBEIN (Boston, Massachusetts); Bruce HAMMOCK (Davis, California); Sung Hee HWANG (Davis, California); Vikas P. SUKHATME (Atlanta, Georgia) |
| ABSTRACT | The invention provides methods for treating, suppressing, or preventing detrimental cytokine and/or lipid mediator surges that can result from a variety of different diseases, conditions, and therapeutic treatments, e.g., by inhibition of cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH). |
| FILED | Friday, January 10, 2020 |
| APPL NO | 17/421785 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/196 (20130101) A61K 31/415 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/06 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087992 | Palczewski et al. |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Krzysztof Palczewski (Cleveland, Ohio); Yuanyuan Chen (Cleveland, Ohio) |
| ABSTRACT | A method of treating retinal degeneration in a subject includes administering to the subject a therapeutically effective amount of a compound of formula (I). |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544454 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) A61K 31/381 (20130101) A61K 31/4402 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088010 | Accili et al. |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Domenico Accili (New York, New York); Takumi Kitamoto (Tokyo, Japan); Hua V. Lin (Zionsville, Indiana) |
| ABSTRACT | Methods are described for producing enteroendocrine cells that make and secrete insulin in a subject by co-administering a Foxo1 inhibitor in combination with a Notch inhibitor or ROCK inhibitor, or both. Also described are pharmaceutical compositions comprising a combination of a Foxo1 inhibitor with a Notch inhibitor or ROCK inhibitor, or both. The described methods and compositions may be used to treat a disorder associated with impaired pancreatic function such as diabetes. |
| FILED | Friday, January 03, 2020 |
| APPL NO | 17/420955 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/192 (20130101) A61K 31/417 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/551 (20130101) A61K 31/4184 (20130101) A61K 31/4409 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088019 | HERGENROTHER et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Paul J. HERGENROTHER (Champaign, Illinois); Jessie PEH (Champaign, Illinois) |
| ABSTRACT | Compositions and methods for the induction of cancer cell death. The compositions and methods include use of compositions in therapy for the treatment of cancer and for the selective induction of apoptosis in cancer cells. The drug combinations described herein can be synergistic and can have lower neurotoxicity effects than the same amounts of other compounds and combinations of compounds and can be effective when a particular cancer has become resistant to previously administered therapies. |
| FILED | Tuesday, September 28, 2021 |
| APPL NO | 17/487473 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/12 (20130101) A61K 9/0019 (20130101) A61K 9/2027 (20130101) A61K 9/2054 (20130101) A61K 9/2059 (20130101) A61K 9/4866 (20130101) A61K 31/437 (20130101) A61K 31/495 (20130101) A61K 31/506 (20130101) Original (OR) Class A61K 31/519 (20130101) A61K 31/4184 (20130101) A61K 31/4439 (20130101) A61K 45/06 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088026 | VERKMAN |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alan S. VERKMAN (San Francisco, California) |
| ABSTRACT | The disclosure is directed to methods of treating tyrosine kinase inhibitor-induced diarrhea by administering a potassium channel inhibitor, or a CFTR chloride channel inhibitor, or a combination thereof. |
| FILED | Thursday, January 16, 2020 |
| APPL NO | 17/423444 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) A61K 31/4164 (20130101) A61K 31/5383 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088031 | Chandra et al. |
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| APPLICANT(S) | Health Research, Inc. (Buffalo, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dhyan Chandra (Buffalo, New York); Rahul Kumar (Buffalo, New York); Neelu Yadav (Buffalo, New York) |
| ABSTRACT | A method for treating prostate cancer in a subject involves selecting a subject having prostate cancer and cytochrome c-deficiency, and administering, to the selected subject, a therapeutically effective amount of one or more agents capable of restoring cytochrome-c activity. Also presented is a method of inducing apoptosis in drug resistant cancer cells involving selecting drug resistant cancer cells having cytochrome-c deficiency, and administering to the selected cells, one or more agents that restore cytochrome-c activity in an amount effective to sensitize said cancer cells to drug induced apoptosis. A combination therapeutic comprising one or more agents increases cytochrome-c activity and efficacy of a chemotherapeutic agent. Another method involves selecting a subject having cancer, and obtaining a cell sample including tumor tissues/biopsy and blood samples from said subject, and further involves measuring cytochrome-c expression levels and Drp1 phosphorylation levels in said sample. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 17/423959 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/136 (20130101) A61K 31/337 (20130101) A61K 31/426 (20130101) A61K 31/555 (20130101) Original (OR) Class A61K 31/565 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088053 | Parker et al. |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roy R. Parker (Boulder, Colorado); Siddharth Shukla (Boulder, Colorado); Luis F.Z. Batista (Clayton, Missouri); Hochang Jeong (St. Louis, Missouri) |
| ABSTRACT | The invention includes methods and compositions for the treatment and prevention of a disease or condition resulting from dysregulation of USB1 and resulting expression of downstream miRNAs. In one preferred embodiment, the invention may include inhibiting the expression or activity of USB1 resulting in the downregulation of downstream miRNA expression. In alternative embodiments, the invention includes methods and compositions for the treatment and prevention of a disease or condition resulting from dysregulation of miRNAs downstream of USB1, namely through the inhibition of PAPD5 and/or PAPD7, resulting in the upregulation of said downstream miRNA expression. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/466448 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 31/4375 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088058 | Aznarez et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cold Spring Harbor Laboratory (Cold Spring Harbor, New York); Stoke Therapeutics, Inc. (Bedford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isabel Aznarez (Jamaica Plain, Massachusetts); Huw M. Nash (Lexington, Massachusetts); Adrian Krainer (East Northport, New York) |
| ABSTRACT | Provided herein are methods and compositions for treating a subject in need thereof, such as a subject with deficient SYNGAP1 protein or SCN1A protein expression or a subject having AD mental retardation 5 or Dravet syndrome. |
| FILED | Wednesday, June 23, 2021 |
| APPL NO | 17/356147 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/712 (20130101) A61K 31/713 (20130101) A61K 31/7125 (20130101) Original (OR) Class A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2310/315 (20130101) C12N 2310/346 (20130101) C12N 2320/33 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088065 | Gladwin et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Thomas Gladwin (Pittsburgh, Pennsylvania); Edwin Parsley (Houston, Texas); Hunter Clay Champion (Midland, Georgia) |
| ABSTRACT | Disclosed herein are methods for treating acute or chronic heart failure using inorganic nitrite, such as sodium nitrite. The method includes administering to a subject in need of treatment a therapeutically effective amount of inorganic nitrite. The nitrite may be administered by inhalation and may be nebulized. The nitrite may be administered at an emitted dose or in an escalated titrated dose. The nitrite may be a liquid formulation or a dry powder formulation. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/540965 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/007 (20130101) A61K 9/0073 (20130101) A61K 31/04 (20130101) A61K 33/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088117 | Lucas et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandra Lucas (Tempe, Arizona); Jordan Yaron (Scottsdale, Arizona); Efrem Lim (Phoenix, Arizona) |
| ABSTRACT | Disclosed herein is are methods of preventing, reducing or inhibiting a viral or immune disorder, comprising administering to a subject at risk or that has acquired a viral or immune disorder an effective amount of a composition comprising a polypeptide derived from a reactive center loop of a serine protease inhibitor or a biologically active variant thereof, wherein the subject has not been administered antibiotics within at least one day of administering the composition. Also disclosed are compositions and kits for preventing, reducing or inhibiting a viral or immune disorder. |
| FILED | Monday, January 13, 2020 |
| APPL NO | 17/422718 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/005 (20130101) A61K 38/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088119 | Dana et al. |
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| FUNDED BY |
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| APPLICANT(S) | SCHEPENS EYE RESEARCH INSTITUTE (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Reza Dana (Cambridge, Massachusetts); Sunil Chauhan (Somerville, Massachusetts) |
| ABSTRACT | Described herein are materials and methods of treating dry eye disease in a subject. |
| FILED | Friday, April 09, 2021 |
| APPL NO | 17/226996 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/44 (20130101) A61K 31/404 (20130101) A61K 31/444 (20130101) A61K 31/502 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/4439 (20130101) A61K 38/12 (20130101) A61K 38/13 (20130101) Original (OR) Class A61K 38/179 (20130101) A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 16/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088127 | Gordon et al. |
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| FUNDED BY |
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| APPLICANT(S) | Temple University - of the Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer Gordon (Philadelphia, Pennsylvania); Kamel Khalili (Bala Cynwyd, Pennsylvania); T. Dianne Langford (Bala Cynwyd, Pennsylvania); Taha Mohseni Ahooyi (Philadelphia, Pennsylvania) |
| ABSTRACT | Compositions in the prevention or treatment of neurodegenerative diseases or disorders associated with human immunodeficiency virus infection include agents which modulate the interactions of HIV Tat and Bcl-2 associated athanogene (BAG) molecules. |
| FILED | Wednesday, January 15, 2020 |
| APPL NO | 17/422628 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088145 | Elson et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| INVENTOR(S) | Charles O. Elson (Birmingham, Alabama); Wayne Duck (Pell City, Alabama); Qing Zhao (Birmingham, Alabama); Katie Alexander (Homewood, Alabama) |
| ABSTRACT | Provided herein are methods and compositions for treating and preventing inflammatory bowel disease. |
| FILED | Friday, February 07, 2020 |
| APPL NO | 17/426234 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 38/164 (20130101) A61K 38/2013 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088152 | Mikati et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | DUKE UNIVERSITY (Durham, North Carolina) |
| INVENTOR(S) | Mohamad Mikati (Durham, North Carolina); Arsen Hunanyan (Durham, North Carolina); Boris Kantor (Durham, North Carolina); Aravind Asokan (Durham, North Carolina); Ram Puranam (Durham, North Carolina); Dwight Koeberl (Durham, North Carolina) |
| ABSTRACT | The present disclosure provides nucleic acid expression cassettes, vectors, compositions and methods for the treatment of ATPase-mediated diseases in a subject. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/524466 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/48 (20130101) Original (OR) Class A61K 48/0058 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088163 | BLAKE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tim R. BLAKE (Palo Alto, California); Robert M. WAYMOUTH (Palo Alto, California); Paul WENDER (Palo Alto, California); Ronald LEVY (Palo Alto, California); Ole Audun Werner HAABETH (Palo Alto, California); Matthew FRANK (Palo Alto, California); Adrienne SALLETS (Palo Alto, California) |
| ABSTRACT | There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo. |
| FILED | Monday, November 11, 2019 |
| APPL NO | 17/292370 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001112 (20180801) Original (OR) Class A61K 47/6935 (20170801) A61K 2039/545 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) A61K 2039/6025 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088164 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Qiong J. Wang (Highland Park, New Jersey); Zhiya Yu (Potomac, Maryland); James C. Yang (Bethesda, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for an HLA-A11-restricted epitope of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) (KRAS7-16), Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog (NRAS), or Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS). Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/535318 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 39/001164 (20180801) Original (OR) Class Peptides C07K 14/82 (20130101) C07K 14/7051 (20130101) Enzymes C12Y 306/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5748 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088170 | VOLKMANN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bavarian Nordic A/S (Kvistgaard, Denmark); Janssen Vaccines and Prevention B.V. (Leiden, Netherlands); The United States of America, as represented by The Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ariane VOLKMANN (Andechs, Germany); Robin STEIGERWALD (Munich, Germany); Ulrike DIRMEIER (Starnberg, Germany); Maria Grazia PAU (Leiden, Netherlands); Benoit Christophe Stephan CALLENDRET (Den Haag, Netherlands); Lucy A. WARD (Silver Spring, Maryland) |
| ABSTRACT | The present invention provides compositions, vaccines and methods for inducing protective immunity against filovirus infection, particularly protective immunity against infection of one or more subtypes of Ebola viruses and Marburg virus. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/450465 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 2039/5256 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088171 | CROYLE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| INVENTOR(S) | Maria A. CROYLE (Austin, Texas); Stephen Clay SCHAFER (Austin, Texas) |
| ABSTRACT | Immunogenic compositions comprising viral vectors and surfactants are provided. Methods for administration and preparation of such compositions are also provided. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/547901 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/543 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/88 (20130101) C12N 2760/14134 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088174 | Marasco et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne A. Marasco (Wellesley, Massachusetts); Corey Watson (Louisville, Kentucky) |
| ABSTRACT | The present invention is directed to methods for mining genotype-repertoire-disease associations. Aspects of the disclosure are also drawn to methods of preparing a vaccine composition. For example, the vaccine composition can be specific to a subject or a group of subjects with a genotype responsive to the vaccine composition. Aspects of the disclosure are further drawn towards methods of vaccinating a subject or a population of subjects. |
| FILED | Monday, October 28, 2019 |
| APPL NO | 17/288684 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088180 | SABETI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (CAMBRIDGE, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (CAMBRIDGE, Massachusetts); THE GENERAL HOSPITAL CORPORATION (BOSTON, Massachusetts); TRUSTEES OF BOSTON UNIVERSITY (BOSTON, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pardis SABETI (Cambridge, Massachusetts); Shira Weingarten-Gabbay (Cambridge, Massachusetts); Susan Klaeger (Cambridge, Massachusetts); Jenn Abelin (Cambridge, Massachusetts); Mohsan Saeed (Boston, Massachusetts); Nir Hacohen (Boston, Massachusetts); Siranush Sarkizova (Cambridge, Massachusetts); Steven Carr (Cambridge, Massachusetts); Karl Clauser (Cambridge, Massachusetts) |
| ABSTRACT | Immunogenic compositions comprising one or more polypeptides, wherein the one or more polypeptides: is capable of binding to Major Histocompatibility Complex (MHC) class I, and is derived from one or more proteins of SARS-CoV-2. Also provided include methods of treating and preventing diseases using the immunogenic compositions. |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/463429 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6818 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088183 | Cassady et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin A. Cassady (Columbus, Ohio); Justin C. Roth (Birmingham, Alabama) |
| ABSTRACT | A chimeric oncolytic virus is described that includes a herpesvirus having a modified nucleic acid sequence, including a modification of the herpesvirus gamma (1)34.5 gene (γ134.5) or a nucleic acid with at least about 70% homology to the γ134.5 gene that reduces its expression; a second viral nucleic acid sequence encoding a PKR evasion protein that does not cause virulence; and a third nucleic acid sequence encoding a tumor-associated antigen. Methods of using the chimeric oncolytic virus to treat subjects having cancer, or to vaccinate subjects at risk of developing cancer, are also described. |
| FILED | Friday, August 30, 2019 |
| APPL NO | 17/271403 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0011 (20130101) A61K 39/245 (20130101) Original (OR) Class A61K 2039/80 (20180801) A61K 2039/5254 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088185 | HEROLD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Betsy HEROLD (Rowayton, Connecticut); William JACOBS, JR. (Pelham, New York); Pablo A. GONZALEZ-MUNOZ (Santiago, Chile); Christopher PETRO (Pleasanton, California) |
| ABSTRACT | Methods for passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such. |
| FILED | Friday, January 03, 2020 |
| APPL NO | 17/420529 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/245 (20130101) Original (OR) Class A61K 2039/54 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16671 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088204 | DEACON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (NEW HAVEN, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John DEACON (Tolland, Connecticut); Venkatareddy SABBASANI (Gaithersburg, Maryland); Denton HOYER (West Haven, Connecticut) |
| ABSTRACT | The present invention provides drug modifications for improving biodistribution and/or specificity of an anticancer drug. In certain embodiments, the compound of the invention comprises a drug, a linker and a core acid. The core acid can be varied to tune the properties of the compound within the body such that the compound more selectively distributes to tumors and is, or becomes active in the cytosol. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/425629 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/145 (20130101) A61K 31/196 (20130101) A61K 31/704 (20130101) A61K 47/555 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088208 | Reshetnyak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rhode Island Board of Trustees (Kingston, Rhode Island); Yale University (New Haven, Connecticut) |
| ASSIGNEE(S) | University of Rhode Island Board of Trustees (Kingston, Rhode Island); Yale University (New Haven, Connecticut) |
| INVENTOR(S) | Yana K. Reshetnyak (Saunderstown, Rhode Island); Oleg A. Andreev (Saunderstown, Rhode Island); Donald M. Engelman (New Haven, Connecticut); Anna Moshnikova (Warwick, Rhode Island); John Deacon (Tolland, Connecticut) |
| ABSTRACT | The invention features a composition comprising an immuno-stimulatory compound and a pHLIP® peptide, e.g., an immunostimulatory compound that comprises a cyclic purine dinucleotide, which binds to a stimulator of interferon genes (STING) such as a cGAMP cyclic compound inside a cell. |
| FILED | Tuesday, January 28, 2020 |
| APPL NO | 17/423849 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/39 (20130101) A61K 47/42 (20130101) A61K 47/64 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088211 | HARDING |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VAXNEWMO LLC (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian HARDING (St. Louis, Missouri) |
| ABSTRACT | Provided herein are glycoproteins containing O-linked glycosylation recognition motifs, and methods of making, for example, for use in the production of conjugate vaccines. |
| FILED | Tuesday, November 05, 2019 |
| APPL NO | 17/416106 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/385 (20130101) A61K 47/65 (20170801) A61K 47/646 (20170801) A61K 47/6415 (20170801) Original (OR) Class A61K 2039/6037 (20130101) Peptides C07K 14/212 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088215 | Roberts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arthur Roberts (Athens, Georgia); Mandi Murph (Athens, Georgia); Sudeepti Kuppa (Athens, Georgia); Pragati Jain (Athens, Georgia) |
| ABSTRACT | Functionalized lipid vesicles having a lipid membrane and a functional element, and methods of making them are provided. The methods of making the vesicles typically include mixing lipid vesicles formed of one or more lipids with one or more lipid conjugates and dialyzing the mixture for an effective amount of time and under conditions suitable for the lipid conjugate to insert into the membrane of lipid vesicles and form functionalized lipid vesicles that include the lipid conjugate as a functional element. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/486381 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6901 (20170801) Original (OR) Class A61K 47/6913 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/141 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088216 | de los Pinos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aura Biosciences, Inc. (Cambridge, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Silver Spring, Maryland) |
| ASSIGNEE(S) | Aura Biosciences, Inc. (Cambridge, Massachusetts); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Silver Spring, Maryland) |
| INVENTOR(S) | Elisabet de los Pinos (Brookline, Massachusetts); John Todd Schiller (Kensington, Maryland); Rhonda C. Kines (Washington, District of Columbia); John MacDougall (Hingham, Massachusetts) |
| ABSTRACT | The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/540549 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 41/0057 (20130101) A61K 41/0071 (20130101) A61K 47/64 (20170801) A61K 47/6901 (20170801) Original (OR) Class A61K 2039/545 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/062 (20130101) Peptides C07K 1/13 (20130101) C07K 14/025 (20130101) C07K 16/32 (20130101) C07K 16/084 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088222 | Cepko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Massachusetts Ear and Eye Infirmary (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Constance L. Cepko (Newton, Massachusetts); David Mingdar Wu (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides compositions, e.g., pharmaceutical compositions, which include a recombinant adeno-associated viral (AAV) expression construct, AAV vectors, AAV particles, and methods of treating a subject having a degenerative ocular disorder, e.g., retinitis pigmentosa. |
| FILED | Wednesday, December 18, 2019 |
| APPL NO | 17/414425 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/00 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/12 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14133 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088228 | Steinmetz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (CLEVELAND, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Steinmetz (San Diego, California); Michael Bruckman (Cleveland, Ohio) |
| ABSTRACT | A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335557 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/1884 (20130101) A61K 49/1896 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/00031 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088229 | Pomper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin G. Pomper (Baltimore, Maryland); Ronnie Charles Mease (Fairfax, Virginia); Ying Chen (Lutherville-Timonium, Maryland) |
| ABSTRACT | Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237850 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 51/0402 (20130101) A61K 51/0455 (20130101) Original (OR) Class General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 275/16 (20130101) C07C 275/18 (20130101) Heterocyclic Compounds C07D 213/61 (20130101) C07D 213/74 (20130101) C07D 213/82 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/2208 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/55 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088268 | Alsberg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eben Alsberg (Cleveland, Ohio); Rui Tang (Solon, Ohio) |
| ABSTRACT | A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544544 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5084 (20130101) A61K 47/02 (20130101) A61K 47/42 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) Original (OR) Class A61L 27/36 (20130101) A61L 27/54 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 14/78 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0068 (20130101) C12N 2533/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088274 | Myung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The U.S. Government Represented by the Department of Veterans Affairs (Washington, District of Columbia); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Myung (Menlo Park, California); Gabriella Fernandes-Cunha (Redwood City, California); Hyun Jong Lee (Redwood City, California); Ali Djalilian (Redwood City, California) |
| ABSTRACT | Compositions and methods for repairing or regenerating damaged tissue are disclosed. In particular, the invention relates to methods of delivering secreted factors from stem cells to tissues in order to immobilize and concentrate such secreted factors at or under the surface of damaged tissue to promote tissue regeneration. |
| FILED | Friday, May 18, 2018 |
| APPL NO | 16/614205 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/51 (20130101) A61K 35/545 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/36 (20130101) A61L 27/52 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 2300/43 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088304 | DASSAU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Eyal DASSAU (Boston, Massachusetts); Ankush CHAKRABARTY (Boston, Massachusetts); Francis J. DOYLE, III (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides for systems and methods for maintaining glycemic control of a patient. An exemplary method can provide for first receiving glucose data from at least one sensor in an intraperitoneal space of the patient. The method can then provide for processing the received glucose data at a glucose monitoring system to yield processed data. The method can then provide for instructing, by the glucose monitoring system, an insulin infusion pump. Instructing the insulin infusion pump can be based on a closed-loop PID control algorithm and the processed data. |
| FILED | Tuesday, November 26, 2019 |
| APPL NO | 17/298417 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4839 (20130101) A61B 5/14532 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 2005/1726 (20130101) A61M 2210/1017 (20130101) A61M 2230/201 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088417 | Stayman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland); Koninklijke Philips NV. (Eindhoven, Netherlands) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Webster Stayman (Baltimore, Maryland); Aswin John Mathews (Baltimore, Maryland); Reuven Levinson (Haifa, Israel) |
| ABSTRACT | The present invention is directed to multiple aperture devices (MADs) for beam shaping in x-ray imaging. Two or more of these binary filters can be placed in an x-ray beam in series to permit a large number of x-ray fluence profiles. However, the relationship between particular MAD designs and the achievable fluence patterns is complex. The present invention includes mathematical and physical models that are used within an optimization framework to find optimal MAD designs. Specifically, given a set of target fluence patterns, the present invention finds, for example, a dual MAD design that is a “best fit” in generating the desired fluence patterns. This process provides a solution for both the design of MAD filters as well as the control actuation that is required (relative motion between MADs) that needs to be specified as part of the operation of a MAD-based fluence field modulation system. |
| FILED | Wednesday, December 08, 2021 |
| APPL NO | 17/545030 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1077 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/00 (20130101) G01N 2223/316 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088556 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daeyeon Lee (Wynnewood, Pennsylvania); Kathleen J. Stebe (Penn Valley, Pennsylvania); Sarah D. Hann (Yardley, Pennsylvania) |
| ABSTRACT | In one aspect of the invention, a microcapsule includes a film encapsulating a material. The film is formed by complexation of at least two mutually attractive components initially present in an aqueous dispersion comprising a continuous phase and a dispersed phase. The at least one first component is initially present in the continuous phase and the at least one second component is initially present in the dispersed phase. According to another aspect of the invention, provided is a process for forming microcapsules including the step of injecting a dispersed phase having at least a first component into a continuous phase having at least a second component, where the first component and the second component are mutually attractive, such that a film is formed by complexation of the first charged component and the second charged component. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/537840 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5031 (20130101) A61K 9/5036 (20130101) A61K 35/74 (20130101) A61K 2035/128 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/04 (20130101) B01J 13/10 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) C12N 11/10 (20130101) C12N 11/082 (20200101) C12N 11/087 (20200101) C12N 11/089 (20200101) C12N 11/098 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088588 | Han et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jongyoon Han (Bedford, Massachusetts); Hyungkook Jeon (Cambridge, Massachusetts) |
| ABSTRACT | Described is a multi-dimensional double spiral (MDDS) microfluidic device comprising a first spiral microchannel and a second microchannel, wherein the wherein the first spiral microchannel and second spiral microchannel have different cross-sectional areas. Also described is a device comprising a multi-dimensional double spiral and system for recirculation. The invention also encompasses methods of separating particles from a sample fluid comprising a mixture of particles comprising the use of the multi-dimensional double spiral microfluidic device. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/488463 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0809 (20130101) B01L 2300/0864 (20130101) B01L 2300/0883 (20130101) B01L 2400/0487 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088601 | SCOTT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MicroGEM International Plc (Southampton, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ORION SCOTT (CHARLOTTESVILLE, Virginia); CHRISTOPHER BIRCH (CHARLOTTESVILLE, Virginia); DANIEL MILLS (CHARLOTTESVILLE, Virginia); BRIAN ROOT (CHARLOTTESVILLE, Virginia); JAMES LANDERS (CHARLOTTESVILLE, Virginia); JINGYI LI (CHARLOTTESVILLE, Virginia); MATTHEW YEUNG (MOUNT WAVERLEY, Australia); DAVID SAUL (DUNEDIN, New Zealand); DAVID VIGIL (MOUNT WAVERLEY, Australia); ANDREW GUY . (MOUNT WAVERLEY, Australia); STAN WADA (MOUNT WAVERLEY, Australia); BETINA DE GORORDO (MOUNT WAVERLEY, Australia); STEWARD DODMAN (MOUNT WAVERLEY, Australia); TOM MORAN (Southampton, United Kingdom); STUART KNOWLES (Mount Waverley, Australia); FERNANDO DIAS (Mount Waverley, Australia); RICK GARDNER (Mount Waverley, Australia) |
| ABSTRACT | A collection device for a biological sample to capture target compounds such as viruses or other pathogens or particles for testing from within the sample and move the captured target compound to a separate chamber for subsequent processing. The collection device can include an openable substance blister including capture particles located in a cup interior. Capture particles can attract and bind the target compounds from the sample. An extraction tube extracts any nucleic acid from the target compound for storage or subsequent amplification and testing to confirm presence of known microorganisms. The extraction tube can comprise a heat-deformable material and can be connected to a microfluidic cartridge for further processing of nucleic acid including, amplification and detection. The microfluidic cartridge includes valves and a plurality of chambers for amplification. |
| FILED | Thursday, August 26, 2021 |
| APPL NO | 17/412354 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502738 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 7/52 (20130101) B01L 2300/18 (20130101) B01L 2300/0832 (20130101) B01L 2300/0864 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/18 (20130101) G01N 1/4022 (20130101) G01N 33/54326 (20130101) G01N 33/56983 (20130101) G01N 2001/1056 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089537 | Koehler et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (, None); President and Fellows of Harvard College (, None) |
| INVENTOR(S) | Angela N. Koehler (Belmont, Massachusetts); Christina Woo (Cambridge, Massachusetts); Catherine Henry (Keswick, Virginia); Chia-Fu Chang (Cambridge, Massachusetts); Sebastian Pomplun (Cambridge, Massachusetts); Jasmin Kruell (Cambridge, Massachusetts); Brice Curtin (Cambridge, Massachusetts) |
| ABSTRACT | Organic compounds for target identification, drug discovery, chemical library production, high-throughput screening, fluorophore conjugation, chemiluminescent compound conjugation, creation of proximity induced modulators (e.g., protein degraders)/chimeric molecules, or a combination thereof are described. The compounds can contain small molecule moieties for identification of their potential targets; an isocyanate, photoactivatable groups; chemical moieties for enrichment and detection of target-small molecule moiety interactions; proximity induced modulator element; fluorophores; chemiluminescent groups; or combinations thereof. |
| FILED | Monday, July 12, 2021 |
| APPL NO | 17/373475 |
| CURRENT CPC | Heterocyclic Compounds C07D 203/04 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/04 (20130101) C40B 50/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089549 | Thompson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul R. Thompson (Wellesley, Massachusetts); Aaron Muth (Brighton, Massachusetts); Venkataraman Subramanian (Worcester, Massachusetts) |
| ABSTRACT | The invention provides novel inhibitors or inactivators of protein arginine deiminases, pharmaceutical compositions and methods of use thereof. The invention also relates to molecular probes based on such compounds and methods of use thereof. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/520603 |
| CURRENT CPC | Heterocyclic Compounds C07D 235/14 (20130101) Original (OR) Class C07D 403/12 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/34 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/582 (20130101) G01N 2333/978 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089565 | Huryn et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Donna M. Huryn (Allentown, Pennsylvania); Peter Wipf (Pittsburgh, Pennsylvania); Matthew G. LaPorte (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present technology is directed to methods of inhibiting or modulating p97 and compounds and compositions useful in such methods. Diseases and conditions that can be treated with the compounds and compositions of the present technology include, but are not limited to, antibacterial infection, antiviral infection, cancer and neurodegenerative disorders susceptible to treatment by inhibition or modulation of p97. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544863 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/04 (20130101) Original (OR) Class C07D 401/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089576 | NATALE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Linnaeus Therapeutics, Inc. (Haddonfield, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher NATALE (Philadelphia, Pennsylvania); Patrick T. MOONEY (Haddonfield, New Jersey); Tina GARYANTES (Warren, New Jersey); Wayne LUKE (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure provides 1) an enantiomerically purified compound SRR G-1, or a derivative thereof, including specific crystal forms, salts and co-crystals that modulates G protein-coupled estrogen receptor activity, 2) pharmaceutical and cosmetic compositions comprising an enantiomerically purified SRR G-1, or a derivative thereof, and 3) methods of treating or preventing disease states and conditions and cosmetic conditions mediated through these receptors and related methods thereof in humans and animals. |
| FILED | Monday, May 24, 2021 |
| APPL NO | 17/328590 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/07 (20130101) C07B 2200/13 (20130101) Heterocyclic Compounds C07D 405/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089577 | TURCHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John J. TURCHI (Indianapolis, Indiana); Navnath GAVANDE (Indianapolis, Indiana); Pamela S. VANDERVERE-CAROZZA (Zionsville, Indiana) |
| ABSTRACT | The present disclosure relates to certain compounds having binding affinity for Ku, and uses thereof. Specifically, the present disclosure relates to the use of Ku inhibitors as described herein in site-specific genome engineering technologies, including but not limited to CRISPR/Cas9, Zinc finger nuclease (ZFN), Transcription activator-like effector nuclease (TALEN), and meganuclease. The present disclosure also relates to kits useful for site-specific genome engineering that include at least one compound as described herein. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/388906 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Heterocyclic Compounds C07D 405/06 (20130101) C07D 405/14 (20130101) Original (OR) Class C07D 409/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089579 | Spiegel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (NEW HAVEN, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Spiegel (New Haven, Connecticut); Christopher Parker (Medina, Ohio) |
| ABSTRACT | The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein. |
| FILED | Thursday, September 09, 2021 |
| APPL NO | 17/470393 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0014 (20130101) A61K 31/496 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 405/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089581 | Lynch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia); Virginia Tech Intellectual Properties, Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin R. Lynch (Charlottesville, Virginia); Yugesh Kharel (Charlottesville, Virginia); Webster L. Santos (Blacksburg, Virginia); Ashley Peralta (Blacksburg, Virginia); Russell G. Fritzemeier (Christiansburg, Virginia); Daniel Foster (Blacksburg, Virginia) |
| ABSTRACT | The present disclosure provides SPNS2 inhibitor compounds according to Formula I and their pharmaceutically acceptable salts, and/or tautomers as described in the disclosure, and the disclosure provides their pharmaceutical compositions and methods of use in therapy. |
| FILED | Wednesday, January 22, 2020 |
| APPL NO | 17/310179 |
| CURRENT CPC | Heterocyclic Compounds C07D 413/04 (20130101) Original (OR) Class C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089602 | Hergenrother et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Paul J. Hergenrother (Champaign, Illinois); Evijola Llabani (Chicago, Illinois) |
| ABSTRACT | The diterpene natural product pleuromutilin was subjected to reaction sequences focused on creating ring system diversity in few synthetic steps. This effort resulted in a collection of compounds with previously unreported ring systems, providing a novel set of structurally diverse and highly complex compounds suitable for screening in a variety of different settings. Biological evaluation identified the novel compound ferroptocide, a small molecule that rapidly and robustly induces ferroptotic death of cancer cells. Target identification efforts and CRISPR knockout studies reveal that ferroptocide is an inhibitor of thioredoxin, a key component of the antioxidant system in the cell. Ferroptocide positively modulates the immune system in a murine model of breast cancer and will be a useful tool to study the utility of pro-ferroptotic agents for treatment of cancer. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/494110 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 487/04 (20130101) Original (OR) Class C07D 521/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089616 | Spokoyny et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Spokoyny (Los Angeles, California); Jessica K. Logan (Los Angeles, California); Azin Saebi (Los Angeles, California); Rafal Dziedzic (Los Angeles, California); Pamela J. Kennedy (Los Angeles, California) |
| ABSTRACT | The present disclosure provides compounds and compositions capable of treating cancer, a disease of the central nervous system, and an inflammatory autoimmune disease, and methods of use thereof. |
| FILED | Wednesday, December 04, 2019 |
| APPL NO | 17/298225 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 211/38 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089638 | LU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (BALTIMORE, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wuyuan LU (Shanghai, China PRC); Xiang LI (Shanghai, China PRC) |
| ABSTRACT | Dithiocarbamate stapled peptides and methods of making and using the same for treating a condition associated with p53, such as cancer, are provided. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/078016 |
| CURRENT CPC | Peptides C07K 1/1077 (20130101) Original (OR) Class C07K 7/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089644 | Diamond |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Feinstein Institutes for Medical Research (Manhasset, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Betty A. Diamond (Bronx, New York) |
| ABSTRACT | Fusion proteins of C1q peptides and HMBG1 A-box or HMBG1 B-box, or C1q peptides and DWESY peptide are provided, and methods of use thereof. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499043 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 7/08 (20130101) Original (OR) Class C07K 14/472 (20130101) C07K 14/4702 (20130101) C07K 16/46 (20130101) C07K 16/2803 (20130101) C07K 2319/00 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089651 | Asokan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aravind Asokan (Chapel Hill, North Carolina); Mavis Agbandje-McKenna (Gainesville, Florida); Long Ping Victor Tse (Carrboro, North Carolina); Brittney Gurda (Collegeville, Pennsylvania) |
| ABSTRACT | The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526510 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/507 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class C07K 16/081 (20130101) C07K 2317/34 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089660 | Pan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wayne State University (Detroit, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhuo-Hua Pan (Troy, Michigan) |
| ABSTRACT | The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant CoChop protein. Methods of the invention include administering a composition comprising a mutant CoChop to a subject to preserve, improve, or restore phototransduction. Preferably, the compositions and methods of the invention are provided to a subject having impaired vision, thereby restoring vision to normal levels. |
| FILED | Wednesday, May 19, 2021 |
| APPL NO | 17/324501 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/405 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089665 | Pereira et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heloise Anne Pereira (Edmond, Oklahoma); Anne KASUS-JACOBI (Midwest City, Oklahoma); Gina L. GRIFFITH (McAlester, Oklahoma) |
| ABSTRACT | Peptide compounds and compositions containing the peptide compounds and methods for treating various infections, wounds, and skin conditions such as atopic dermatitis. Examples of wounds that may be treated include surface wounds such as lacerations, abrasions, avulsions, incisions, and amputations, pressure sores, bed sores, wounds due to peripheral vascular disease, post-surgical wounds, diabetic ulcers and wounds, burns, ocular wounds and abrasions, ocular ulcers, and treatment of inflammatory conditions such as dry eye. The peptide compounds and compositions may be used as treatments to enhance acceptance of grafts such as skin grafts and organ grafts. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532307 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/17 (20130101) A61K 38/1729 (20130101) A61K 45/06 (20130101) Peptides C07K 14/4723 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089670 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF ROCHESTER (Rochester, New York); THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tingting Yang (Rochester, New York); Yu Zhang (Rochester, New York); Stephen Tsang (New York, New York) |
| ABSTRACT | The present invention provides compositions and methods for treatment of bestrophinopathies. In certain embodiments, the invention treats, improves retinal function, and prevents progression of disorder in a subject with retinal degenerative disorder. The present invention comprises administration of a composition comprising wild-type BEST1 gene to subjects with a BEST1 mutation, in need of improved retinal function. |
| FILED | Friday, December 27, 2019 |
| APPL NO | 17/415858 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) Peptides C07K 14/705 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/062 (20130101) C12N 2510/00 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089673 | Yoseph et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Rami Yoseph (Gaithersburg, Maryland); Maria R. Parkhurst (Ellicott City, Maryland); Anna Pasetto (Stockholm, Sweden); Steven A. Rosenberg (Potomac, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated human RAS amino acid sequence with a substitution of glycine at position 12 with arginine. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Tuesday, January 21, 2020 |
| APPL NO | 17/424591 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/7051 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089677 | Tran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Eric Tran (Portland, Oregon); Yong-Chen Lu (Rockville, Maryland); Anna Pasetto (Stockholm, Sweden); Paul F. Robbins (Chevy Chase, Maryland); Steven A. Rosenberg (Potomac, Maryland); Zhili Zheng (Gaithersburg, Maryland) |
| ABSTRACT | Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/541619 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/82 (20130101) C07K 14/7051 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) G01N 2333/7051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089694 | Sullivan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Nancy J. Sullivan (Kensington, Maryland); John Misasi (Kensington, Maryland); Brandon Dekosky (Lawrence, Kansas); Kendra Elizabeth Leigh (Frankfurt, Germany) |
| ABSTRACT | Human monoclonal antibodies that specifically bind Ebola virus glycoprotein with nanomolar affinity are described. The monoclonal antibodies were isolated by bulk sorting of plasmablasts from a human Ebola virus vaccinee and pairing of the immunoglobulin heavy and light chain genes using emulsion PCR. The paired immunoglobulin genes were expressed using Fab yeast display to screen and characterize the antibodies. The Ebola virus-specific monoclonal antibodies can be used, for example, to diagnose and treat Ebola virus infection or Ebola virus disease in a subject. |
| FILED | Thursday, December 19, 2019 |
| APPL NO | 17/415412 |
| CURRENT CPC | Peptides C07K 16/10 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/08 (20130101) G01N 2800/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089696 | BRANCO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana); THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California); THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas); ZALGEN LABS, LLC (Germantown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis M. BRANCO (Germantown, Maryland); Robert F. GARRY (New Orleans, Louisiana); James E. ROBINSON (New Orleans, Louisiana); Erica O. SAPHIRE (La Jolla, California); Kathryn M. HASTIE (La Jolla, California); Thomas W. GEISBERT (Albany, Texas) |
| ABSTRACT | Disclosed herein are compositions comprising arenavirus monoclonal antibodies, as well as therapeutic, diagnostic, and preventative methods using the novel antibodies. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules, peptides) that inhibit Old World arenavirus infectivity, including LASV and LCMV. In some embodiments, the antibodies provide pan-arenavirus protection against a number of arenavirus types and strains. Diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses are also disclosed, as well as new tools and methods for the design, production, and use of arenavirus monoclonal antibodies, including expression in engineered bacterial- and mammalian-based systems. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/520338 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 16/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089717 | McNally et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | IKAIKA THERAPEUTICS, INC. (Oak Park, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth McNally (Oak Park, Illinois); Ahlke Heydemann (Oak Park, Illinois); Ermelinda Ceco (Chicago, Illinois) |
| ABSTRACT | The disclosure relates to compositions and methods of mitigating tissue damage and fibrosis in a patient by modulating latent transforming growth factor beta binding protein (LTBP4)-induced proteolysis of a TGFβ superfamily protein. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/536768 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) A61K 39/3955 (20130101) A61K 39/39533 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Peptides C07K 7/08 (20130101) C07K 16/18 (20130101) C07K 16/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089752 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin Liu (San Francisco, California); Namkyung Lee (San Francisco, California); Yang Su (San Francisco, California); Scott Bidlingmaier (San Francisco, California) |
| ABSTRACT | Provided herein are compositions and methods for modulating internalization properties of cell surface molecules, e.g., converting a non-internalizing cell surface antigen into an internalizing one, and vice versa. In some embodiments, provided are engineered antibodies each containing an antigen binding moiety specific for a guide-antigen and another antigen binding moiety specific for an effector antigen, wherein the internalization property of the engineered antibody or functional fragment thereof is determined by a relative surface density ratio of the guide antigen to the effector antigen. Also provided are recombinant cells, recombinant nucleic acids encoding such engineered antibodies, as well as pharmaceutical compositions containing same. The disclosure also provides methods useful for modulating cellular internalization in a cell or a subject, as well as methods for modulating cell-type selective signaling in a subject and/or for the treatment of diseases. |
| FILED | Tuesday, January 14, 2020 |
| APPL NO | 17/422591 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) A61K 47/6805 (20170801) A61K 47/6809 (20170801) A61K 47/6817 (20170801) A61K 47/6849 (20170801) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2803 (20130101) C07K 16/2866 (20130101) Original (OR) Class C07K 2317/56 (20130101) C07K 2317/73 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089777 | Gruber et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aronora, Inc. (Portland, Oregon); Oregon Health and Science University (Portland, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andras Gruber (Portland, Oregon); Erik I Tucker (Portland, Oregon); Christina U Lorentz (Portland, Oregon) |
| ABSTRACT | Novel binding molecules, comprising humanized antibodies, fragments, variants, and derivatives thereof, compositions, methods, and kits comprising the same, are described, wherein the binding molecules specifically bind to FXI and FXIa. The binding molecules are capable of binding to and forming an immune complex with the factor XI A2 domain, and thereby disrupting the contact activation molecular complex without affecting hemostatic factor XI activity or activation. The binding molecule of this disclosure is useful in safely inhibiting thrombosis and inflammation without compromising hemostasis. The binding molecules, compositions, methods, and kits provided herein are therefore intended to treat, inter alia, thrombosis- and inflammation-related diseases and conditions. Moreover, polynucleotides encoding the binding molecules of this disclosure, vectors comprising the polynucleotides, and host cells for producing the polynucleotides are provided. |
| FILED | Monday, January 20, 2020 |
| APPL NO | 17/424338 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) A61K 31/4709 (20130101) A61K 38/58 (20130101) A61K 38/482 (20130101) A61K 39/3955 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/02 (20180101) Peptides C07K 16/36 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/92 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089784 | Marks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James D. Marks (Kensington, California); Maria Consuelo Garcia Rodriguez (San Francisco, California) |
| ABSTRACT | The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/541837 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 16/1282 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089821 | OAKEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John OAKEY (Laramie, Wyoming); Benjamin NOREN (Laramie, Wyoming); Zhongliang JIANG (Laramie, Wyoming); Kun JIANG (Laramie, Wyoming) |
| ABSTRACT | Embodiments of the present disclosure generally relate to compositions comprising hydrogel-encapsulated/dispersed beta cells, compositions comprising hydrogel-encapsulated/dispersed beta-cell spheroids, processes for forming such compositions, and uses of the compositions. In an embodiment, a composition is provided that includes a first component comprising a hydrogel, the hydrogel comprising, in polymerized form, one or more photoreactive monomers and a thiol linker. The composition further comprises a second component comprising a plurality of beta cells dispersed or encapsulated within the hydrogel. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/482143 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/28 (20130101) C08J 3/075 (20130101) Original (OR) Class C08J 2333/02 (20130101) C08J 2371/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/37 (20130101) Compositions of Macromolecular Compounds C08L 33/02 (20130101) C08L 71/08 (20130101) C08L 2203/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0676 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090000 | OAKEY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John OAKEY (Laramie, Wyoming); John KISIDAY (Fort Collins, Colorado); Benjamin NOREN (Laramie, Wyoming) |
| ABSTRACT | Embodiments of the present disclosure generally relate to apparatus for isolating biological material, processes for fabricating such apparatus, and processes for using such apparatus. In an embodiment, an apparatus for isolating a biological material is provided. The apparatus includes a fluidic channel disposed over a portion of a substrate. The apparatus further includes a hydrogel structure disposed in the fluidic channel, the hydrogel structure comprising a plurality of wells, wherein each well of the plurality of wells has a diameter from about 1 μm to about 500 μm, the hydrogel structure comprising, in polymerized form, one or more photoreactive monomers. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484381 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502761 (20130101) B01L 2200/12 (20130101) B01L 2200/0647 (20130101) B01L 2300/123 (20130101) B01L 2300/0829 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 47/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090009 | Thomson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James A. Thomson (Madison, Wisconsin); Jue Zhang (Madison, Wisconsin) |
| ABSTRACT | The present invention relates to chemically defined and xenogeneic material-free methods for deriving endothelial cells from human pluripotent stem cells. In particular, the present invention provides highly efficient and reproducible methods of obtaining human endothelial cells from human pluripotent stem cells, where endothelial cells derived from the methods provided herein are suitable for clinically relevant therapeutic applications. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/540023 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/069 (20130101) Original (OR) Class C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) C12N 2501/415 (20130101) C12N 2501/727 (20130101) C12N 2506/45 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090021 | Tsai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Li-Huei Tsai (Cambridge, Massachusetts); Joel Blanchard (Arlington, Massachusetts) |
| ABSTRACT | The present disclosure provides, in some embodiments, in vitro blood brain barrier (iBBB) having functional properties of in vivo BBB as well as methods of identifying compounds capable of traversing the iBBB. Compounds capable of crossing the iBBB and therapeutic uses of such compounds are also described. |
| FILED | Wednesday, January 22, 2020 |
| APPL NO | 17/424529 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0622 (20130101) C12N 5/0691 (20130101) Original (OR) Class C12N 2502/28 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) G01N 33/5064 (20130101) G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090026 | Steinmetz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (Cleveland, Ohio); Amy M. Wen (Cleveland, Ohio) |
| ABSTRACT | Virus particle multimers and methods of making and using such virus particle multimer are described. Virus particle multimers are constructed by preparing a plurality of asymmetrically functionalized virus particles bearing one or more functional groups and contacting the asymmetrically functionalized virus particles with a first linker molecule that reacts with the functional groups to form a virus particle multimer that includes a plurality of asymmetrically functionalized virus particles connected by the linker molecule. The asymmetrically functionalized virus particles are typically prepared by attaching the virus particles to a support surface to allow asymmetrical functionalization to be introduced. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544518 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2770/32023 (20130101) C12N 2770/32051 (20130101) C12N 2770/32142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090055 | KRAUSS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRANDEIS UNIVERSITY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Isaac J. KRAUSS (Needham Heights, Massachusetts); Satoru HORIYA (Somerville, Massachusetts); Jennifer BAILEY (Waltham, Massachusetts) |
| ABSTRACT | The invention relates to a glycopeptide that includes one or more modified amino acid residues having a sidechain comprising a monosaccharide or an oligosaccharide, wherein the glycopeptide binds specifically to a carbohydrate-binding monoclonal antibody from PGT128 family, preferably with an affinity of less than 100 nM. Immunogenic conjugates that include the glycopeptide, and pharmaceutical compositions that include the glycopeptide or the immunogenic conjugate are also disclosed. Various method of using the glycopeptides, immunogenic conjugates, and pharmaceutical compositions are disclosed, including inducing an immune response, inhibiting viral infection, treating a cancerous condition, and detecting a neutralizing antibody. |
| FILED | Thursday, October 24, 2019 |
| APPL NO | 17/288414 |
| CURRENT CPC | Peptides C07K 19/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1058 (20130101) Original (OR) Class C12N 15/1062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090070 | Lieberman Aiden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); BAYLOR COLLEGE OF MEDICINE (Houston, Texas) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (, None); BAYLOR COLLEGE OF MEDICINE (, None) |
| INVENTOR(S) | Erez Lieberman Aiden (Houston, Texas); Eric S. Lander (Cambridge, Massachusetts); Suhas Rao (Houston, Texas); Su-Chen Huang (Houston, Texas); Adrian L. Sanborn (Houston, Texas); Neva C. Durand (Houston, Texas); Miriam Huntley (Houston, Texas); Andrew Jewett (Houston, Texas) |
| ABSTRACT | Chromatin 3D structure modulating agents in the context of the present invention are intended to interfere or manipulate the function of loop anchor motifs, such as CTCF motifs. In certain example embodiments, the present invention may block formation of an loop anchor or chromatin domain or induce formation of a loop anchor or chromatin domain at a targeted genomic location. For instance, a loop anchor motif can be altered, such as by mutating (including inverting) a binding motif so as to remove such a motif, or by adding new binding motifs in new locations within a loop domain, so as to reduce the size of an existing loop, so as to modify the size of an existing loop, or combinations thereof. Alternatively, the chromatin 3D structure modulating agent may bind a target region and mask a loop anchor motif, thereby preventing a loop anchor or chromatin domain from forming. The chromatin 3D structure modulating agent may bind a target region and cause a loop anchor of chromatin domain to form. |
| FILED | Tuesday, August 10, 2021 |
| APPL NO | 17/398951 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090071 | Singh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ravindra N. Singh (Shrewsbury, Massachusetts); Natalia N. Singh (Shrewsbury, Massachusetts); Nirmal K. Singh (Temple, Texas); Elliot J. Androphy (Natick, Massachusetts) |
| ABSTRACT | The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the SMN2 ISS-N1 site in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The ISS-N1 blocking agents of the invention cause elevated expression of SMN protein, thus compensating for the loss of SMN protein expression commonly observed in subjects with spinal muscular atrophy (SMA). |
| FILED | Thursday, August 19, 2021 |
| APPL NO | 17/406718 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/315 (20130101) C12N 2310/322 (20130101) C12N 2320/30 (20130101) C12N 2320/33 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) G01N 2500/04 (20130101) G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090076 | Ju et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Jingfang Ju (East Setauket, New York); Andrew Fesler (Sound Beach, New York); Younghwa Song (Port Jefferson Station, New York); Jun Chung (Setauket, New York) |
| ABSTRACT | The present disclosure provides nucleic acid compositions that incorporate one or more halouracil molecules. More specifically, the present disclosure reveals that the replacement of uracil nucleotides within a microRNA nucleotide sequence with a 5-halouracil increases the ability of the micro-RNA to inhibit cancer progression and tumorigenesis. As such, the present disclosure provides various nucleic acid (e.g., microRNA) compositions having 5-halouracil molecules incorporated in their nucleic acid sequences and methods for using the same. The present disclosure further provides pharmaceutical compositions comprising the modified nucleic acid compositions, and methods for treating cancers using the same. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/534520 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090079 | Jo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hanjoong Jo (Atlanta, Georgia); Joan Fernandez Esmerats (Atlanta, Georgia); Nicolas Villa-Roel (Brookhaven, Georgia) |
| ABSTRACT | This disclosure relates to the use of miRNA-483 and its target genes, UBE2C, pVHL and HIF1alpha, in managing the treatment of cardiovascular and inflammatory diseases. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a miR-483 mimic and/or an HIF inhibitor and a pharmaceutically acceptable excipient for use in treating or preventing a vascular disease or condition. In certain embodiments, the miR-483 mimic is a double stranded nucleobase polymer or an expression vector that expresses mature human miR-483-5p and miR-483-3p sequences or operable fragments and variants. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544801 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/713 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/113 (20130101) C12N 2310/141 (20130101) C12N 2310/3231 (20130101) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090083 | Hahn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); INSTITUTO CARLOS SLIM DE LA SALUD, A.C. (Mexico, D.F., Mexico, Mexico) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts); INSTITUTO CARLOS SLIM DE LA SALUD, A.C. (Mexico, D.F., Mexico, Mexico) |
| INVENTOR(S) | William Hahn (Boston, Massachusetts); Francisca Vazquez (Cambridge, Massachusetts); Colles Price (Boston, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of EGLN1-dependent cancers. In particular, the instant disclosure provides for identification of a cancer as EGLN1-dependent, and selection and/or administration of an inhibitor of EGLN1 or VHL (Von Hippel-Lindau Tumor Suppressor) as a therapeutic agent for such a cancer and/or subject having or at risk of developing such a cancer. |
| FILED | Wednesday, September 11, 2019 |
| APPL NO | 17/275061 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1135 (20130101) Original (OR) Class C12N 15/1137 (20130101) C12N 2320/11 (20130101) C12N 2320/30 (20130101) Enzymes C12Y 114/11029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090086 | Zack et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald J. Zack (Baltimore, Maryland); Derek S. Welsbie (Lutherville-Timonium, Maryland) |
| ABSTRACT | Drug targets, pathways, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502311 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/553 (20130101) A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2320/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) C12Q 1/6883 (20130101) C12Q 2600/136 (20130101) Enzymes C12Y 207/10 (20130101) C12Y 207/11 (20130101) C12Y 207/99 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2500/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090089 | Regev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aviv Regev (Cambridge, Massachusetts); Evgenij Fiskin (Cambridge, Massachusetts) |
| ABSTRACT | Described in several embodiments herein are engineered phagemids and bacteriophages containing the same. Also described in several embodiments herein are methods of using the engineered phagemids and bacteriophages containing the same. In some embodiments, the engineered phagemids and bacteriophages containing the same are capable of providing multi-omic information at the single-cell level. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484067 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Original (OR) Class C12N 15/1037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090097 | Curtiss, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Arizona Board of Regents for and on Behalf of Arizona State University (Scottsdale, Arizona); The Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roy Curtiss, III (Gainesville, Florida); Shifeng Wang (Gainesville, Florida); Soo-Young Wanda (Gainesville, Florida); Wei Kong (Phoenix, Arizona) |
| ABSTRACT | The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/500940 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 39/00 (20130101) A61K 2035/11 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/36 (20130101) C12N 15/74 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090137 | Asokan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aravind Asokan (Chapel Hill, North Carolina); Erin Borchardt (Naperville, Illinois); Rita Meganck (Raleigh, North Carolina); William F. Marzluff (Hillsborough, North Carolina) |
| ABSTRACT | This invention is directed to AAV compositions for circular RNA expression and methods of expressing covalently closed, circular RNA. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506089 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090139 | RAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Catholic University of America (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venigalla B. RAO (Washington, District of Columbia); Jingen ZHU (Washington, District of Columbia) |
| ABSTRACT | Described is an “artificial virus” (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546183 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2795/00043 (20130101) C12N 2795/00051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090145 | Joung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Morgan Maeder (Brookline, Massachusetts) |
| ABSTRACT | Methods and constructs for RNA-guided targeting of heterologous functional domains such as transcriptional activators to specific genomic loci. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/450135 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 2319/00 (20130101) C07K 2319/01 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/22 (20130101) C12N 9/0071 (20130101) C12N 9/96 (20130101) C12N 9/1007 (20130101) C12N 15/01 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/1031 (20130101) C12N 2310/20 (20170501) C12N 2710/00033 (20130101) C12N 2770/00033 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 114/11 (20130101) C12Y 201/01 (20130101) C12Y 301/00 (20130101) C12Y 301/21004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090146 | Jacobs, Jr. et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Albert Einstein College of Medicine (Bronx, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William R. Jacobs, Jr. (Bronx, New York); Lawrence Leung (Flushing, New York); Regy Lukose (Flanders, New Jersey); Anna Paula de Oliveira (Bronx, New York) |
| ABSTRACT | A genetically modified mammalian cell and genetically modified mammalian cell line comprise a recombination sequence inserted in a target locus on a chromosome of the mammalian cell genome, wherein the recombination sequence comprises Bxb1attB sequence from Mycobacterium smegmatis. A transgenic mammalian cell and transgenic mammalian cell line comprise a heterologous nucleic acid stably integrated in a target locus on a chromosome of the mammalian genome, wherein the heterologous nucleic comprises a heterologous gene configured for expression by the transgenic mammalian cell. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484476 |
| CURRENT CPC | Peptides C07K 14/35 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2710/16652 (20130101) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090163 | Pierce et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Niles A Pierce (Pasadena, California); Harry M.T. Choi (Pasadena, California) |
| ABSTRACT | The present disclosure relates to methods and compositions involving HCR reactions that involve initiators that are split into two or more parts. Effective HCR is dependent upon two or more of these split initiators being brought into proximity (e.g., via binding events mediated by a target) such that a full initiator is formed that is capable of triggering HCR signal amplification. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/457572 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) Original (OR) Class C12Q 1/6816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090164 | AIDEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (, None); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (, None); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (, None) |
| INVENTOR(S) | Erez Lieberman AIDEN (Houston, Texas); Mitchell GUTTMAN (West Hollywood, California); Elena STAMENOVA (Reading, Massachusetts); Eric S. LANDER (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed is a method for detecting spatial proximity relationships between RNA and DNA molecules in a cell. The method includes: providing a sample of RNA and DNA wherein the RNA and DNA have ends capable ofjoining to other DNA and RNA, respectively; joining at least one end of the fragmented RNA to the end of at least one fragmented DNA, to create at least one joined RNA-DNA hybrid molecule, wherein the join encodes the information about the proximity of the RNA and DNA in the cell; reverse transcribing the at least one joined rRNA-DNA hybrid molecule to create least one target join DNA molecule that retains the information of the join, and determining the sequence of the target join thereby detecting spatial proximity relationships between RNA and DNA molecules in a cell. |
| FILED | Monday, March 29, 2021 |
| APPL NO | 17/216570 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6841 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090167 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Notre Dame du Lac (Notre Dame, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ceming Wang (South Bend, Indiana); Hsueh-Chia Chang (South Bend, Indiana) |
| ABSTRACT | Described herein is a method for high-efficiency virus enrichment and purification using an asymmetric nanopore membrane (ANM) filtration technology. The ANM design prevents viral particle deformation, lysing, and fusion due to the strong external force and thus significant increases the yield while preserving other advantages of size-based ultrafiltration. It also offers a unique feature of being able to flush the contaminating proteins from the viral particles. It offers higher throughput, yield, sample purity, concentration factor, and more precise size fractionation than current approaches. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474296 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2740/15051 (20130101) C12N 2770/18051 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/6806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090176 | Rao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Children's Medical Center Corporation (Boston, Massachusetts); The United States of America, As Represented by the Secretary, Department of Health and Human Servies (Bethesda, Maryland) |
| ASSIGNEE(S) | The Children's Medical Center Corporation (Boston, Massachusetts); The United States of America, As Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Anjana Rao (La Jolla, California); Mamta Tahiliani (New York, New York); Kian Peng Koh (Jamaica Plain, Massachusetts); Suneet Agarwal (Belmont, Massachusetts); Aravind Iyer (Bethesda, Maryland) |
| ABSTRACT | The present invention provides for methods of epigenetic analysis. In some cases, the methods may include obtaining a sample comprising a nucleic acid sequence. In some cases, the nucleic acid sequence may comprise one or more epigenetic marks. The methods may include performing a sequencing. The methods may include distinguishing a hydroxymethylated base from a methylated base. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528492 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1007 (20130101) C12N 2501/70 (20130101) C12N 2501/71 (20130101) C12N 2501/724 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/26 (20130101) C12Q 1/6806 (20130101) C12Q 1/6827 (20130101) Original (OR) Class C12Q 1/6869 (20130101) C12Q 2521/531 (20130101) C12Q 2522/10 (20130101) C12Q 2537/164 (20130101) C12Q 2600/154 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090178 | Abudayyeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Omar Abudayyeh (Cambridge, Massachusetts); James Joseph Collins (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Feng Zhang (Cambridge, Massachusetts); Eric S. Lander (Cambridge, Massachusetts) |
| ABSTRACT | The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/241382 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 7/52 (20130101) B01L 2300/0825 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6816 (20130101) C12Q 1/6823 (20130101) C12Q 1/6827 (20130101) C12Q 1/6832 (20130101) Original (OR) Class C12Q 1/6876 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/558 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090201 | Wang |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wang-Xia Wang (Lexington, Kentucky) |
| ABSTRACT | A treatment method for cerebral vasospasm involves determining amounts of let-7b-5p, miR-9-3p, miR-142-3p, miR-15b-5p, miR-17-5p, miR-19b-3p, miR-20a-5p, miR-24-3p, miR-29a-3p, miR-125b-5p, and miR-142-3p in a biological sample obtained from a subject following aneurysmal subarachnoid hemorrhage (aSAH) to identify the subject as having an elevated risk of cerebral vasospasm, and administering a treatment to the subject when the elevated risk of cerebral vasospasm is identified. |
| FILED | Tuesday, September 07, 2021 |
| APPL NO | 17/468439 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4422 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/178 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090203 | Janne et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Pasi A. Janne (Needham, Massachusetts); Cloud P. Paweletz (Boston, Massachusetts); Geoffrey Oxnard (Arlington, Massachusetts); Yanan Kuang (Belmont, Massachusetts) |
| ABSTRACT | The invention provides methods to monitor cell free nucleic acids. The method comprises obtaining a plasma sample from a subject known to have a cancer characterized by a pair of mutually exclusive mutations specific to the cancer; isolating cell free nucleic acids from the plasma sample obtained from the subject; measuring the amount a housekeeping gene and/or total DNA in the cell free nucleic acids isolated from the plasma sample to confirm that the amount of housekeeping gene and/or total DNA in the sample is within a selected range; measuring the amount of a first of the pair of mutually exclusive mutations specific to the cancer in the cell free nucleic acids isolated from the plasma sample; and indicating in a report that the subject has the first mutation when (a) the amount of the housekeeping gene and/or total DNA in the cell free nucleic acids isolated from the plasma sample is within the selected range and (b) the amount of the first mutation is increased as compared to a control amount, wherein the control amount is determined by measuring the apparent amount of the first mutation in control cell free nucleic acids isolated from plasma samples obtained from control subjects known to have the second of the pair of mutually exclusive mutations specific to the cancer using measuring conditions substantially the same as those used to measure the amount of the first mutation in the cell free nucleic acids isolated from the plasma sample from the subject. |
| FILED | Thursday, November 12, 2020 |
| APPL NO | 17/096817 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/517 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090206 | Schell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); Gibbs Cancer Center and Research Institute (Spartanburg, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Schell (Temple Terrace, Florida); Timothy Yeatman (Greenville, South Carolina) |
| ABSTRACT | Disclosed are gene signatures that may be used to predict the recurrence of colorectal cancer in a human patient. These signatures can be used to determine when to treat a patient with post-operative adjuvant chemotherapy, i.e., when a high risk of colorectal cancer recurrence is predicted. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/347003 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091014 | SWAMI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan SWAMI (Charlottesville, Virginia); Walter VARHUE (Charlottesville, Virginia); Vahid FARMEHINI (Charlottesville, Virginia) |
| ABSTRACT | An exemplary method and system is disclosed that facilitate the integration of on-chip impedance sensors and measurement circuitries, e.g., in characterizing internal microfluidic structures and/or in cell or particle cytometry, for quantifying the impedance/frequency response of microfluidic device under the same, or similar, conditions used for particle manipulation. In some embodiments, the exemplary method and system employs a circuit configured for automated determination and quantification of parasitic voltage drops during AC electrokinetic particle manipulation, without the need to use valuable biological samples or model particles. The determined impedance response can be used to assess efficacy of the microfluidic device geometry as well as to provide control signals to inform downstream cell separation decisions. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/425414 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502761 (20130101) B01L 2200/0647 (20130101) B01L 2300/0627 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1031 (20130101) Original (OR) Class G01N 33/4833 (20130101) G01N 2015/0065 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 27/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091040 | KRISHNASWAMY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bhuvana KRISHNASWAMY (Madison, Wisconsin); Megan N. MCCLEAN (Madison, Wisconsin) |
| ABSTRACT | Devices, systems and methods for biological sensing and communication using optogenetics and electronics are described. One example method includes generating a light beam incident on multiple regions in a device, wherein each region comprises an optogenetic system to generate, upon interacting with the light beam, biosensors, wherein an interaction between the biosensors and stimulus molecules in each region is associated with a threshold for a production of an output molecule or an alteration of an output property of the output molecule, the biosensors, or the stimulus molecules, wherein the production or the alteration is based on a value associated with an information source, detecting an output received from one or more of the multiple regions corresponding to the output molecule or the output property in that region, and generating an electric signal associated therewith, and processing the electrical signal to determine the value associated with the information source. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/480654 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 2300/0663 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/02 (20130101) C12M 23/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 15/81 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/865 (20210501) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) Original (OR) Class G01N 33/533 (20130101) Transmission H04B 10/80 (20130101) H04B 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091044 | NGUYEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| INVENTOR(S) | Phuong-Diem NGUYEN (Tucson, Arizona); Judith SU (Tucson, Arizona); Adley GIN (Tucson, Arizona); Erol OZGUR (Tucson, Arizona) |
| ABSTRACT | An optical system includes an optical resonant cavity, an optical source, an optical detector, and a signal processing circuit. The optical source is arranged to provide a source beam of light to be at least partially coupled into the optical resonant cavity. The optical detector is arranged to detect light from the source beam of light after the source beam of light has coupled into the optical resonant cavity to provide a detection signal. The signal processing circuit is configured to communicate with the optical detector to receive the detection signal. The optical resonant cavity has a bioconjugatable lipid membrane on a surface thereof. The bioconjugatable lipid membrane is functionalized to capture a specific biomolecule, and the signal processing circuit is further configured to determine a presence of the specific biomolecule when captured by the functionalized bioconjugatable lipid membrane based on processing the detection signal. |
| FILED | Monday, January 27, 2020 |
| APPL NO | 17/425243 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/7746 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091099 | Sharei et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Armon R. Sharei (Cambridge, Massachusetts); Marc Lajoie (Seattle, Washington); Klavs F. Jensen (Lexington, Massachusetts); Robert S. Langer (Newton, Massachusetts) |
| ABSTRACT | Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404286 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5002 (20130101) Original (OR) Class G01N 33/48721 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091100 | Anderson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clifford Anderson (Tempe, Arizona); Dmitry Derkach (Gilbert, Arizona); Deirdre Meldrum (Phoenix, Arizona); Laimonas Kelbauskas (Gilbert, Arizona) |
| ABSTRACT | A method for analyzing cells through measurement of live-cell parameters followed by measurement of gene and protein expression is disclosed herein. The method comprises measuring one or more live-cell parameters for a plurality of cells contained in at least one liquid in a plurality of isolated microchambers of a microarray device. The method further comprises removing a lid bounding the plurality of isolated microchambers. The method further comprises microdispensing a quantity of lysate into each microchamber of the plurality of isolated microchambers. The method further comprises microdispensing a quantity of reverse transcription polymerase chain reaction mix into each microchamber of the plurality of isolated microchambers. The method further comprises microdispensing a quantity of oil into each microchamber of the plurality of isolated microchambers. The method further comprises incorporating the microarray device into a thermal cycling apparatus with a window permitting epifluorescence imaging of the plurality of isolated microchambers. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/538353 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6452 (20130101) G01N 21/6486 (20130101) G01N 33/5005 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091111 | Gendelman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of the Regents of the University of Nebraska (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Howard E. Gendelman (Omaha, Nebraska); R. Lee Mosley (Omaha, Nebraska); Jessica A. Saunders (Stanford, California) |
| ABSTRACT | Methods and compositions for detecting and diagnosing Parkinson's disease are disclosed. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544007 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/53 (20130101) G01N 33/6896 (20130101) G01N 33/54306 (20130101) Original (OR) Class G01N 2800/2835 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091129 | ZHAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jingjie PTM Biolab (Hangzhou) Co., Inc (Hangzhou, China PRC) |
| ASSIGNEE(S) | Jingjie PTM Biolab (Hangzhou) Co., Inc (Hangzhou, China PRC) |
| INVENTOR(S) | Yingming ZHAO (Chicago, Illinois); Di Zhang (Hangzhou, China PRC); Lunzhi DAI (Chicago, Illinois) |
| ABSTRACT | The invention provides an isolated peptide comprising a lactylated lysine and a specific affinity reagent that specifically binds to a lactylated lysine in a peptide. Also provided are a method for detecting a lactylated lysine in a protein or a fragment thereof using the affinity reagent and a method for isolating the affinity reagent. |
| FILED | Thursday, December 19, 2019 |
| APPL NO | 17/416955 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6812 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091130 | MARCOTTE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward MARCOTTE (Austin, Texas); Eric V. ANSLYN (Austin, Texas); Andrew ELLINGTON (Austin, Texas); Jagannath SWAMINATHAN (Austin, Texas); Erik HERNANDEZ (Austin, Texas); Amber JOHNSON (Austin, Texas); Alexander BOULGAKOV (Austin, Texas); James L. BACHMAN (Austin, Texas); Helen SEIFERT (Austin, Texas) |
| ABSTRACT | Identifying proteins and peptides, and more specifically large-scale sequencing of single peptides in a mixture of diverse peptides at the single molecule level is an unmet challenge in the field of protein sequencing. Herein are methods for identifying amino acids in peptides, including peptides comprising unnatural amino acids. In one embodiment, the N-terminal amino acid is labeled with a first label and an internal amino acid is labeled with a second label. In some embodiments, the labels are fluorescent labels. In other embodiments, the internal amino acid is Lysine. In other embodiments, amino acids in peptides are identified based on the fluorescent signature for each peptide at the single molecule level. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/491797 |
| CURRENT CPC | Peptides C07K 17/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/582 (20130101) G01N 33/6818 (20130101) G01N 33/6824 (20130101) Original (OR) Class G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091133 | Hotchkiss et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri); University of Cincinnati (Cincinnati, Ohio); University of Florida Research Foundation, Incorporated (Gainsville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Hotchkiss (St. Louis, Missouri); Isaiah Turnbull (St. Louis, Missouri); Monty Mazer (St. Louis, Missouri); Kenneth Remy (St. Louis, Missouri); Charles Caldwell (Cincinnati, Ohio); Lyle Moldawer (Gainesville, Florida); Scott Brakenridge (Seattle, Washington) |
| ABSTRACT | A method of immune phenotyping (evaluating adaptive and innate immune status) a subject is disclosed that includes providing a biological sample comprising diluted whole blood or isolated peripheral blood mononuclear cells (PBMCs), quantitating T cell interferon-gamma (IFN-γ) and monocyte TNF-α production using ELISpot in the biological sample comprising diluted whole blood, and determining that the subject has an immunosuppressive immunological endotype if T cell interferon-gamma (IFN-γ) and/or monocyte TNF-α production are decreased or low compared to a healthy subject. The disclosed method may be used to evaluating drug efficacy by measuring immune function in a subject after administering a drug to the subject to determine changes in the immune function of the subject in response to the drug. |
| FILED | Monday, September 20, 2021 |
| APPL NO | 17/479326 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) Original (OR) Class G01N 33/6893 (20130101) G01N 2333/57 (20130101) G01N 2333/525 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091134 | ZHAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PTM Biolab Inc. (Hangzhou, China PRC) |
| ASSIGNEE(S) | PTM Biolab Inc. (Hangzhou, China PRC) |
| INVENTOR(S) | Yingming ZHAO (Chicago, Illinois); Lunzhi DAI (Chicago, Illinois) |
| ABSTRACT | The invention provides an isolated peptide comprising a lysine 2-hydroxyisobutyrylation site, a lysine 2-hydroxyisobutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 2-hydroxyisobutyrylation in a sample using the reagent. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526241 |
| CURRENT CPC | Peptides C07K 16/18 (20130101) C07K 16/44 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6875 (20130101) Original (OR) Class G01N 2440/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091200 | Gerginov |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladislav Gerginov (Boulder, Colorado) |
| ABSTRACT | The disclosure describes optically pumped magnetometers and systems incorporating, and methods of operating, the same. An optically pumped magnetometer according to one embodiment of the present technology includes a vapor cell configured to contain an atomic absorber such as rubidium—87, and at least one light source in optical communication with the vapor cell. The optically pumped magnetometer includes components positioned and configured to provide a bias field, and induce a zeroing field, within the vapor cell. Among other useful and advantageous ends, embodiments of the present technology provide for increasing the degree of atomic polarization in optically pumped magnetometers based on zeroing the bias magnetic field during the optical pumping process. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166594 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093271 | Huang |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Hospital Medical Center (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin Huang (Cincinnati, Ohio) |
| ABSTRACT | Computer implemented methods, systems, and computer readable medium are provided for performing causal inference analyses to determine the more effective treatment among alternative treatments in the healthcare setting using real world observational data. Both binary treatment and adaptive treatment strategies are considered in the analysis. The methods comprise generating a Bayesian marginal structural model and performing a single step of Bayesian regression that incorporates matching, weighting, and estimation processes and in which the matching process is performed using a Guassian process (“GP”) prior covariance function. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/310176 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/20 (20180101) G16H 50/70 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093380 | Xia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu Xia (West Lafayette, Indiana); Zheng Ouyang (West Lafayette, Indiana); Xiaoxiao Ma (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to methods for analyzing a tissue sample. In certain aspects, the invention provides methods that involve obtaining a tissue sample including an unsaturated compound, conducting a radical reaction on the tissue sample that targets a carbon-carbon double bond within the unsaturated compound to thereby produce a plurality of compound isomers, subjecting the plurality of compound isomers to mass spectrometry analysis to identify a location of the carbon-carbon double bond within the unsaturated compound, and quantifying the plurality of compound isomers in order to distinguish normal tissue from diseased tissue. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231224 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0241 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 1/405 (20130101) G01N 30/00 (20130101) G01N 30/88 (20130101) G01N 30/7233 (20130101) G01N 33/92 (20130101) G01N 2030/8813 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0004 (20130101) H01J 49/04 (20130101) H01J 49/0031 (20130101) H01J 49/0409 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220087565 | Loh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth Loh (San Diego, California); Yun-An Lin (San Diego, California) |
| ABSTRACT | Systems and methods relating to a smart elastic fabric tape are disclosed. For example, a method may include interrogating a sensing mesh using an electrical impedance tomography (EIT) device, wherein the sensing mesh is affixed onto skin nearby a musculoskeletal (MSK) region of interest, wherein the sensing mesh comprises a nanocomposite thin film disposed on elastic fabric tape, and wherein the sensing mesh forms a geometrical pattern on the skin; generating, in real-time, EIT conductivity maps from interrogating the sensing mesh; and generating, in real time, strain distribution and strain directionality data of the MSK region of interest based on the EIT conductivity maps. |
| FILED | Monday, July 19, 2021 |
| APPL NO | 17/379522 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0536 (20130101) Original (OR) Class A61B 5/6831 (20130101) A61B 2562/046 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220087595 | Egorov |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vladimir Egorov (Princeton, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Egorov (Princeton, New Jersey) |
| ABSTRACT | The Biomechanical Integrity Score and its five components are calculated as a result of vaginal tactile probe insertion, elevation, rotation, Valsalva maneuver, voluntary pelvic muscle contraction, reflex contraction, and relaxation while the probe is in contact with vaginal walls for a comprehensive biomechanical characterization of the pelvic floor. The probe is equipped with a plurality of tactile sensors recording various static and dynamic pressure patterns during a vaginal examination. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526271 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0053 (20130101) A61B 5/4337 (20130101) Original (OR) Class A61B 5/4884 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088028 | Caspary et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Southern Illinois University (Springfield, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald Caspary (Springfield, Illinois); Thomas Brozoski (Springfield, Illinois); Brandon Cox (Springfield, Illinois) |
| ABSTRACT | A method for treating a subject with symptoms of tinnitus and pharmaceutical compositions for treating tinnitus, the pharmaceutical compositions comprising one or more of the following: sazetidine, a pharmaceutically acceptable salt of sazetidine, varenicline, a pharmaceutically acceptable salt of varenicline, or any combination thereof. |
| FILED | Thursday, February 06, 2020 |
| APPL NO | 17/428164 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) Original (OR) Class A61K 31/4427 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088092 | Collins et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Daniel S. Collins (Cambridge, Massachusetts); Jonathan M. Stokes (Cambridge, Massachusetts); Luis R. Soenksen (Cambridge, Massachusetts); James J. Collins (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure relates to compositions, methods, and kits for increasing the viability of bacteria that have been subjected to freeze-drying/lyophilization. In particular, the disclosure relates to compositions and methods for increasing the viability of living medicines (e.g., probiotics) during lyophilization, oral rehydration, and passage through the gastrointestinal tract |
| FILED | Tuesday, January 21, 2020 |
| APPL NO | 17/424291 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/19 (20130101) A61K 9/0053 (20130101) A61K 35/741 (20130101) A61K 35/744 (20130101) A61K 35/745 (20130101) A61K 35/747 (20130101) Original (OR) Class A61K 36/064 (20130101) A61K 47/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088133 | Migrino et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); Midwestern University (Downers Grove, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond Q. Migrino (Phoenix, Arizona); Volkmar Weissig (Glendale, Arizona) |
| ABSTRACT | Disclosed herein are compositions comprising nanoliposomes useful for the treatment and prevention of stroke. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/472324 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 31/7105 (20130101) A61K 38/1709 (20130101) A61K 38/1761 (20130101) Original (OR) Class A61K 47/24 (20130101) A61K 47/28 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088229 | Pomper et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin G. Pomper (Baltimore, Maryland); Ronnie Charles Mease (Fairfax, Virginia); Ying Chen (Lutherville-Timonium, Maryland) |
| ABSTRACT | Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237850 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 51/0402 (20130101) A61K 51/0455 (20130101) Original (OR) Class General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 275/16 (20130101) C07C 275/18 (20130101) Heterocyclic Compounds C07D 213/61 (20130101) C07D 213/74 (20130101) C07D 213/82 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/2208 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/55 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088274 | Myung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The U.S. Government Represented by the Department of Veterans Affairs (Washington, District of Columbia); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Myung (Menlo Park, California); Gabriella Fernandes-Cunha (Redwood City, California); Hyun Jong Lee (Redwood City, California); Ali Djalilian (Redwood City, California) |
| ABSTRACT | Compositions and methods for repairing or regenerating damaged tissue are disclosed. In particular, the invention relates to methods of delivering secreted factors from stem cells to tissues in order to immobilize and concentrate such secreted factors at or under the surface of damaged tissue to promote tissue regeneration. |
| FILED | Friday, May 18, 2018 |
| APPL NO | 16/614205 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/51 (20130101) A61K 35/545 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/36 (20130101) A61L 27/52 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 2300/43 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089611 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Nicholas Paul Kwiatkowski (Brookline, Massachusetts); Jie Jiang (Brookline, Massachusetts); Mingfeng Hao (Hefei, China PRC); Zhixiang He (Brookline, Massachusetts) |
| ABSTRACT | The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The compounds of the present disclosure are inhibitors of kinases (e.g., a cyclin-dependent kinase (CDK) (e.g., CDK7)). The compounds may be selective for inhibiting the activity of a kinase (e.g., CDK7) over certain other kinases (e.g., CDK2, CDK9, CDK12). Also provided are pharmaceutical compositions, kits, methods of use, and uses that involve the compounds. The compounds may be useful in inhibiting the activity of a kinase, down-regulating the transcription of MYC or MCL-1, inhibiting the growth of a cell, inducing apoptosis of a cell, treating a disease, and/or preventing a disease (e.g., proliferative disease, cystic fibrosis). |
| FILED | Friday, December 27, 2019 |
| APPL NO | 17/418353 |
| CURRENT CPC | Heterocyclic Compounds C07D 487/04 (20130101) C07D 519/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089784 | Marks et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James D. Marks (Kensington, California); Maria Consuelo Garcia Rodriguez (San Francisco, California) |
| ABSTRACT | The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/541837 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 16/1282 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089989 | Ingber et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald E. Ingber (Boston, Massachusetts); Andries Van der Meer (Enschede, Netherlands); Anna Herland (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for producing and using a body having a first structure defining a first chamber, a second structure defining a second chamber, a membrane located at an interface region between the first chamber and the second chamber to separate the first chamber from the second chamber. The first chamber comprises a first permeable matrix disposed therein and the first permeable matrix comprises at least one or a plurality of lumens each extending therethrough, which is optionally lined with at least one layer of cells. The second chamber can comprise cells cultured therein. The systems and methods described herein can be used for various applications, including, e.g., growth and/or differentiation of primary cells, and/or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents). The systems and methods can also permit co-cultures of two or more different cell types. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/540619 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) C12M 25/14 (20130101) C12M 29/10 (20130101) C12M 35/08 (20130101) C12M 41/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0618 (20130101) C12N 5/0622 (20130101) C12N 2502/081 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090092 | THESS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CureVac AG (Tübingen, Germany) |
| ASSIGNEE(S) | CureVac AG (Tübingen, Germany) |
| INVENTOR(S) | Andreas THESS (Kusterdingen, Germany); Thomas SCHLAKE (Gundelfingen, Germany); Stefanie GRUND (Stuttgart, Germany) |
| ABSTRACT | The invention relates to an artificial nucleic acid molecule comprising an open reading frame and a 3′-UTR comprising at least one poly(A) sequence or a polyadenylation signal. The invention further relates to a vector comprising the artificial nucleic acid molecule comprising an open reading frame and a 3′-UTR comprising at least one poly(A) sequence or a polyadenylation signal, to a cell comprising the artificial nucleic acid molecule or the vector, to a pharmaceutical composition comprising the artificial nucleic acid molecule or the vector and to a kit comprising the artificial nucleic acid molecule, the vector and/or the pharmaceutical composition. The invention also relates to a method for increasing protein production from an artificial nucleic acid molecule and to the use of a 3′-UTR for a method for increasing protein production from an artificial nucleic acid molecule. Moreover, the invention concerns the use of the artificial nucleic acid molecule, the vector, the kit or the pharmaceutical composition as a medicament, as a vaccine or in gene therapy. |
| FILED | Sunday, December 05, 2021 |
| APPL NO | 17/542430 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) A61K 39/205 (20130101) A61K 48/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 15/68 (20130101) C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090136 | HOOPER |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of The United States, as represented by The Secretary of The Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jay HOOPER (New Market, Maryland) |
| ABSTRACT | The invention contemplates a new synthetic, codon-optimized Sin Nombre virus (SNV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The SNV ORF was cloned into a plasmid to form the first stable recombinant SNV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a vaccine system, and is useful to protect mammals against infection with Sin Nombre virus. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492291 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 2039/70 (20130101) Peptides C07K 14/005 (20130101) C07K 16/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2760/12111 (20130101) C12N 2760/12121 (20130101) C12N 2760/12122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090145 | Joung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | J. Keith Joung (Winchester, Massachusetts); Morgan Maeder (Brookline, Massachusetts) |
| ABSTRACT | Methods and constructs for RNA-guided targeting of heterologous functional domains such as transcriptional activators to specific genomic loci. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/450135 |
| CURRENT CPC | Peptides C07K 14/005 (20130101) C07K 14/195 (20130101) C07K 2319/00 (20130101) C07K 2319/01 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/22 (20130101) C12N 9/0071 (20130101) C12N 9/96 (20130101) C12N 9/1007 (20130101) C12N 15/01 (20130101) C12N 15/11 (20130101) C12N 15/63 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 15/1031 (20130101) C12N 2310/20 (20170501) C12N 2710/00033 (20130101) C12N 2770/00033 (20130101) C12N 2800/80 (20130101) Enzymes C12Y 114/11 (20130101) C12Y 201/01 (20130101) C12Y 301/00 (20130101) C12Y 301/21004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090163 | Pierce et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Niles A Pierce (Pasadena, California); Harry M.T. Choi (Pasadena, California) |
| ABSTRACT | The present disclosure relates to methods and compositions involving HCR reactions that involve initiators that are split into two or more parts. Effective HCR is dependent upon two or more of these split initiators being brought into proximity (e.g., via binding events mediated by a target) such that a full initiator is formed that is capable of triggering HCR signal amplification. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/457572 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) Original (OR) Class C12Q 1/6816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090178 | Abudayyeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Omar Abudayyeh (Cambridge, Massachusetts); James Joseph Collins (Cambridge, Massachusetts); Jonathan Gootenberg (Cambridge, Massachusetts); Feng Zhang (Cambridge, Massachusetts); Eric S. Lander (Cambridge, Massachusetts) |
| ABSTRACT | The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA. |
| FILED | Tuesday, April 27, 2021 |
| APPL NO | 17/241382 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 7/52 (20130101) B01L 2300/0825 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6816 (20130101) C12Q 1/6823 (20130101) C12Q 1/6827 (20130101) C12Q 1/6832 (20130101) Original (OR) Class C12Q 1/6876 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/558 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090587 | Perna et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Accion Systems, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Louis Perna (Boston, Massachusetts); Bradley Kaanta (Boston, Massachusetts); Russell Merrick (Boston, Massachusetts); Adam Zachar (Boston, Massachusetts); Kellen Blake (Boston, Massachusetts); William Maulbetsch (Boston, Massachusetts); Dakota Freeman (Boston, Massachusetts); Andrew Wollman (Boston, Massachusetts); Joseph Zimo (Boston, Massachusetts); Myles Greenough (Boston, Massachusetts) |
| ABSTRACT | A system can include a reservoir configured to hold working material, a decontamination module configured to remove contaminants from the working material, a flow control mechanism configured to regulate working material flow between the reservoir and the decontamination module, and a manifold fluidly connecting the reservoir to the decontamination module. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/410157 |
| CURRENT CPC | Producing a Reactive Propulsive Thrust, Not Otherwise Provided for F03H 1/0012 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090788 | Duncan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beverly Stephenson Duncan (West Chester, Ohio); Steven Joseph Lohmueller (Reading, Ohio); Eric John Stevens (Mason, Ohio) |
| ABSTRACT | A trapped vortex combustor for use in a gas turbine engine includes an outer vortex chamber wall and a dome attached to, or formed integrally with, the outer vortex chamber wall. The dome, the outer vortex chamber wall, or both define at least in part an outer trapped vortex chamber and a channel. The channel extends along the circumferential direction at a forward end of the outer vortex chamber wall, the channel configured to receive an airflow through or around the outer vortex chamber wall, the dome, or both and provide such airflow as a continuous annular airflow to the inner surface of the outer vortex chamber wall. The dome further defines a fuel nozzle opening, with all openings in the dome outward of the fuel nozzle opening along the radial direction, excepting any effusion cooling holes having a diameter less than about 0.035 inches, being in airflow communication with the channel. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/542900 |
| CURRENT CPC | Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/002 (20130101) F23R 3/06 (20130101) Original (OR) Class F23R 3/12 (20130101) F23R 3/286 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090882 | Howell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRIGHAM YOUNG UNIVERSITY (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Larry L. Howell (Provo, Utah); Spencer P. Magleby (Provo, Utah); David C. Morgan (Provo, Utah); Terri Bateman (Provo, Utah); Jeffrey E. Niven (Provo, Utah); Alex Avila (Provo, Utah); Erica Crampton (Provo, Utah); Kyler Tolman (Provo, Utah); Jacob Greenwood (Provo, Utah); Peter Schleede (Provo, Utah) |
| ABSTRACT | An example barrier can be switchable between an at least partially collapsed state and at least partially expanded state (e.g., a deployed state). For example, the barrier can be formed from a continuous sheet and a plurality of rigid sections (e.g., rigid panels) attached or incorporated into the continuous sheet. The barrier can also include a plurality of hinges, such as hinge lines, between the panels that are formed from the continuous sheet. The hinges enable the barrier to be rigid foldable (e.g., the hinges can fold and unfold while the rigid sections remain stiff and rigid) between the expanded and collapsed states. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539436 |
| CURRENT CPC | Additional Work, Such as Equipping Roads or the Construction of Platforms, Helicopter Landing Stages, Signs, Snow Fences, or the Like E01F 13/02 (20130101) Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 9/06 (20130101) E06B 2009/007 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/04 (20130101) F41H 5/06 (20130101) Original (OR) Class F41H 5/013 (20130101) F41H 5/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090917 | NAJAFI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Khalil NAJAFI (Ann Arbor, Michigan); Sajal SINGH (Ann Arbor, Michigan); Jae Yoong CHO (Ann Arbor, Michigan) |
| ABSTRACT | Three-dimensional (3D) micro-scale shells are presented with openings of various sizes and geometries on the surface. The shell consist of a suspended ring-shaped resonator, multiple support beams, a support post, and a cap region that connects the support beams to the support post. Shells with openings of various sizes and geometries allow the creation of micro electromechanical systems (MEMS) sensors and actuators with a wide range of engineered mechanical and electrical properties. The openings on the shell surface can, for example, control the mechanical quality factor (Q) and resonance frequencies of the shell when the shell is used as a suspended proof mass of a mechanical resonator of a vibratory gyroscope. The shells can also serve as mechanical supporting layers and/or an electrode connection layer for MEMS actuators and sensors that use 3D shells as proof masses. |
| FILED | Thursday, March 18, 2021 |
| APPL NO | 17/205562 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/005 (20220101) G01C 19/5783 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091019 | Berg et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew J. Berg (Manhattan, Kansas); Osku P. Kemppinen (Hyattsville, Maryland); Gorden W. Videen (Silver Spring, Maryland) |
| ABSTRACT | A device includes a filter that enhances a beam profile of a received pulsed laser; a first optical element to direct the pulsed laser as a reference wave towards an optical sensor; an open cavity positioned between the first optical element and the optical sensor. The open cavity receives an aerosol particle, which enters the open cavity from any direction. The reference wave illuminates the aerosol particle. An illuminated particle generates and directs an object wave towards the optical sensor. A pixel array is connected to the optical sensor. The pixel array receives the reference wave and the object wave. The optical sensor creates a contrast hologram comprising an interference pattern of the illuminated particle. A processor creates an image of the illuminated particle based on the contrast hologram. |
| FILED | Monday, September 21, 2020 |
| APPL NO | 17/027131 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0205 (20130101) G01N 15/1463 (20130101) Original (OR) Class G01N 2015/0065 (20130101) G01N 2015/0233 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091105 | Beshay et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intelligent Optical Systems, Inc. (Torrance, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manal Beshay (Rancho Palos Verdes, California); Janet L Jensen (Aberdeen, Maryland); James M Cress (Aberdeen, Maryland) |
| ABSTRACT | Transparent indicator tape is used for the detection of airborne chemicals in a suspect environment. In various embodiments, the indicator tape is affixed to a window or lens wherein one or more colorimetric indicators clad to the tape are exposed to the environment while humans or detection devices on the other side of the window or lens are not necessarily subjected to the suspect environment. In various embodiments the colorimetric indicator is sensitive to chemical warfare agents. Airborne chemicals including chemical warfare agents may detected by visual review or autonomous measurement of sensor color changes when in the presence of a target chemical. In various embodiments, the an indicator spot is split into sensitive and insensitive regions such that colorimetric changes may be more readily identified against a visually changing background. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/543684 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/783 (20130101) G01N 33/52 (20130101) Original (OR) Class G01N 33/0057 (20130101) G01N 2021/7759 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091110 | Hunt |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Joseph R. Hunt (King George, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Joseph R. Hunt (King George, Virginia) |
| ABSTRACT | A method is provided for detecting a biological analyte in a medium. The method includes enclosing a catalyst in an encapsulate that includes an associated binder; adding reactants to the medium, followed by adding the encapsulate that contains the encapsulate to the medium. In response to presence of the analyte in the medium, the binder attaches to the analyte and opens the encapsulate to release the catalyst. The catalyst accelerates chemical change of the reactants into products. The method continues by detecting the products to register presence of the analyte. |
| FILED | Tuesday, September 22, 2020 |
| APPL NO | 17/027970 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5432 (20130101) G01N 33/54306 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091121 | NAKSHATRI |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Harikrishna NAKSHATRI (Zionsville, Indiana) |
| ABSTRACT | Methods and compositions are provided for detecting and/or determining a patient's risk of cancer. The methods utilize categorizing the source of biopsy samples based on patient ancestry mapping in combination with cancer markers to identify patients at higher risk of cancer. |
| FILED | Monday, November 25, 2019 |
| APPL NO | 17/298234 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091130 | MARCOTTE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward MARCOTTE (Austin, Texas); Eric V. ANSLYN (Austin, Texas); Andrew ELLINGTON (Austin, Texas); Jagannath SWAMINATHAN (Austin, Texas); Erik HERNANDEZ (Austin, Texas); Amber JOHNSON (Austin, Texas); Alexander BOULGAKOV (Austin, Texas); James L. BACHMAN (Austin, Texas); Helen SEIFERT (Austin, Texas) |
| ABSTRACT | Identifying proteins and peptides, and more specifically large-scale sequencing of single peptides in a mixture of diverse peptides at the single molecule level is an unmet challenge in the field of protein sequencing. Herein are methods for identifying amino acids in peptides, including peptides comprising unnatural amino acids. In one embodiment, the N-terminal amino acid is labeled with a first label and an internal amino acid is labeled with a second label. In some embodiments, the labels are fluorescent labels. In other embodiments, the internal amino acid is Lysine. In other embodiments, amino acids in peptides are identified based on the fluorescent signature for each peptide at the single molecule level. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/491797 |
| CURRENT CPC | Peptides C07K 17/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/58 (20130101) G01N 33/582 (20130101) G01N 33/6818 (20130101) G01N 33/6824 (20130101) Original (OR) Class G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091200 | Gerginov |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladislav Gerginov (Boulder, Colorado) |
| ABSTRACT | The disclosure describes optically pumped magnetometers and systems incorporating, and methods of operating, the same. An optically pumped magnetometer according to one embodiment of the present technology includes a vapor cell configured to contain an atomic absorber such as rubidium—87, and at least one light source in optical communication with the vapor cell. The optically pumped magnetometer includes components positioned and configured to provide a bias field, and induce a zeroing field, within the vapor cell. Among other useful and advantageous ends, embodiments of the present technology provide for increasing the degree of atomic polarization in optically pumped magnetometers based on zeroing the bias magnetic field during the optical pumping process. |
| FILED | Wednesday, February 03, 2021 |
| APPL NO | 17/166594 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091232 | Foreman |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Terry Lee Foreman (Colonial Beach, Virginia) |
| ASSIGNEE(S) | United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Terry Lee Foreman (Colonial Beach, Virginia) |
| ABSTRACT | A computer-implemented method is provided for detecting a target amidst clutter by a radar system able to transmit an electromagnetic signal, receive first and second echoes respectively from the target and the clutter, and process the echoes. The method includes determining signal convolution matrix for the target and a target return phase, clutter amplitude by spatial correlation matrix of clutter, clutter correlation matrix, receive noise power; querying whether the clutter moves as a motion condition if satisfied and as a stationary condition otherwise; calculating signal convolution matrix and target return phase from the signal convolution matrix and the target return phase for target motion; querying whether the target has range migration as a migration condition if satisfied and as a non-migration condition otherwise; and forming a target detector for the radar. The motion condition further includes calculating signal convolution matrix from clutter motion, clutter range migration matrix from the clutter motion, and interference correlation matrix. The stationary condition further includes calculating the interference correlation. The migration condition further includes calculating range migration matrix from the target motion. |
| FILED | Tuesday, June 30, 2020 |
| APPL NO | 16/916525 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/414 (20130101) Original (OR) Class G01S 13/003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091249 | Raghavan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramachandran S. Raghavan (Centerville, Ohio) |
| ABSTRACT | A radar system provides a transmitter that transmits a sequence of transmitted pulses in a transmit beam, receiving antenna array comprised of more than one element, and a receiver communicatively coupled to the receiving antenna area to receive received signal that comprises in-phase and quadrature samples collected of a reflected version of the sequence of transmitted pulses. A signal processing and target detection module resolves a received signal-plus-interference into different range cells based on a time delay between the transmitted pulse and the received signal, wherein a response from a range cell to a transmitted pulse is due to a target within the transmit beam and moving at an unknown velocity. An interference suppression module suppresses interference and test for presence of a target tested at each of a set of hypothesized azimuth angles and Doppler frequencies. |
| FILED | Monday, September 20, 2021 |
| APPL NO | 17/479641 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/023 (20130101) G01S 7/292 (20130101) G01S 13/5244 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091281 | Romanyukha |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland) |
| ASSIGNEE(S) | The United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland) |
| INVENTOR(S) | Alexander A. Romanyukha (Rockville, Maryland) |
| ABSTRACT | An alanine criticality accident dosimeter comprising at least two alanine pellets and at least two alanine pellets enhanced with moderator, and each pair of alanine pellet and enhanced alanine pellet is covered with a neutron filer or a photon filter. An improved method to determine radiation dose of a subject after an accident by measuring alanine pellets from a criticality accident dosimeter with neutron sensitivity, and improved discrimination between photon and neutron dose contributions. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484531 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091312 | Kunz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Kunz (Washington, District of Columbia); Fredrik Fatemi (McLean, Virginia); Kevin Cox (Laurel, Maryland); David Meyer (Burtonsville, Maryland) |
| ABSTRACT | A conical mirror concentrator is disclosed which is configured for use as a laser-cooled cooled atom source. According to embodiments, the conical mirror concentrator may comprise a body; a reflective inner conical surface formed on the body tapering from a large diameter at a first side of body inward to a smaller dimeter in an interior space of the body, wherein the inner conical surface focuses light to an axis within the interior space of the body; a hole extending from the interior space of the body near a pinnacle of the inner conical surface to a second, opposite side of body; and a structure configured to mount the concentrator to an ultra-high vacuum chamber, such as a CF (or Conflat) flange or an anodicly bonded glass plate. |
| FILED | Wednesday, September 23, 2020 |
| APPL NO | 17/029585 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 15/00 (20130101) Optical Elements, Systems, or Apparatus G02B 5/10 (20130101) Original (OR) Class Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 3/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091474 | CHOI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Hyeongrak CHOI (Cambridge, Massachusetts); Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | It remains a challenge to generate coherent radiation in the spectral range of 0.1-10 THz (“the THz gap”), a band for applications ranging from spectroscopy to security and high-speed wireless communications. Here, we disclose how to produce coherent radiation spanning the THz gap using efficient second-harmonic generation (SHG) in low-loss dielectric structures, starting from an electronic oscillator (EO) that generates coherent radiation at frequencies of about 100 GHz. The EO is coupled to cascaded, hybrid THz-band dielectric cavities that combine (1) extreme field concentration in high-quality-factor resonators with (2) nonlinear materials enhanced by phonon resonances. These cavities convert the input radiation into higher-frequency coherent radiation at conversion efficiencies of >103%/W, making it possible to bridge the THz gap with 1 W of input power. This approach enables efficient, cascaded parametric frequency converters, representing a new generation of light sources extensible into the mid-IR spectrum and beyond. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/384861 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/37 (20130101) G02F 1/392 (20210101) Original (OR) Class G02F 1/3503 (20210101) G02F 1/3551 (20130101) G02F 2202/32 (20130101) G02F 2203/13 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091634 | Martin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Shea T Martin (Dayton, Ohio); Peter J Voland (Beavercreek, Ohio); Patrick E Assef (Dayton, Ohio) |
| ABSTRACT | A field-operable tactical operations management system. The system includes a case and a field interface within the case. The case has a rigid base and a rigid lid that is pivotally coupled to the rigid base. The field interface includes a power management system, a plurality of compartments, a user input device, and a display. The power management system stores energy, powers the field interface, or both. Each of the plurality of compartments receives a peripheral device. The display is operably coupled to the rigid lid of the case. The field interface is configured to be operably coupled to an end user device, which enables the end user device to be operated by way of the field interface with the user input device. |
| FILED | Friday, September 18, 2020 |
| APPL NO | 17/025250 |
| CURRENT CPC | Purses; Luggage; Hand Carried Bags A45C 5/00 (20130101) A45C 13/02 (20130101) A45C 15/00 (20130101) A45C 2013/026 (20130101) Electric Digital Data Processing G06F 1/1628 (20130101) Original (OR) Class Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 5/0017 (20130101) H05K 5/0239 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220092366 | Chiu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Han-Pang Chiu (West Windsor, New Jersey); Junjiao Tian (Atlanta, Georgia); Zachary Seymour (Pennington, New Jersey); Niluthpol C. Mithun (Lawrenceville, New Jersey) |
| ABSTRACT | Techniques are disclosed for an image understanding system comprising a machine learning system that applies a machine learning model to perform image understanding of each pixel of an image, the pixel labeled with a class, to determine an estimated class to which the pixel belongs. The machine learning system determines, based on the classes with which the pixels are labeled and the estimated classes, a cross entropy loss of each class. The machine learning system determines, based on one or more region metrics, a weight for each class and applies the weight to the cross entropy loss of each class to obtain a weighted cross entropy loss. The machine learning system updates the machine learning model with the weighted cross entropy loss to improve a performance metric of the machine learning model for each class. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/478177 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/628 (20130101) G06K 9/6256 (20130101) G06K 9/6265 (20130101) G06K 9/6277 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220092420 | LU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intelligent Fusion Technology, Inc. (Germantown, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jingyang LU (Germantown, Maryland); Erik BLASCH (Arlington, Virginia); Roman ILIN (Dayton, Ohio); Hua-mei CHEN (Germantown, Maryland); Dan SHEN (Germantown, Maryland); Nichole SULLIVAN (Germantown, Maryland); Genshe CHEN (Germantown, Maryland) |
| ABSTRACT | Embodiments of the present disclosure provide a method, a device, and a storage medium for domain adaptation for efficient learning fusion (DAELF). The method includes acquiring data from a plurality of data sources of a plurality of sensors; for each of the plurality of sensors, training an auxiliary classifier generative adversarial network (AC-GAN) by a hardware processor with data from each data source of the plurality of data sources, thereby obtaining a trained feature extraction network and a trained label prediction network for each data source; forming a decision-level fusion network or a feature-level fusion network; and training the decision-level fusion network or the feature-level fusion network with a source-only mode or a generate to adapt (GTA) mode; and applying the trained decision-level fusion network or the trained feature-level fusion network to detect a target of interest. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/480999 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00624 (20130101) G06K 9/629 (20130101) G06K 9/6232 (20130101) G06K 9/6256 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093302 | Murdoch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Army Combat Capabilities Development Command, Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heather A. Murdoch (Baltimore, Maryland); Efrain Hernandez (Bel Air, Maryland); Denise Yin (Columbia, Maryland) |
| ABSTRACT | An apparatus includes an electrochemical cell with an electrolyte solution containing particles and metal ions; an electrode system disposed in the electrolyte solution, wherein the electrode system includes a counter electrode, a reference electrode, and a working electrode, and wherein the counter electrode and the working electrode are arranged to allow electric current to flow therebetween; and an open-bore magnet arrangement having at least one permanent magnet connected to the electrochemical cell and arranged to produce a magnetic field in the electrolyte solution to interact with the electric current to produce an electrodeposition of the particles with metal derived from the metal ions onto the working electrode. |
| FILED | Tuesday, September 22, 2020 |
| APPL NO | 17/028081 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 7/021 (20130101) H01F 7/0221 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093376 | Christian |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Leidoc, Inc. (Reston, Virginia) |
| ASSIGNEE(S) | Leidos, Inc. (Reston, Virginia) |
| INVENTOR(S) | Noah Peter Christian (San Diego, California) |
| ABSTRACT | A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544599 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/004 (20130101) Original (OR) Class H01J 49/0013 (20130101) H01J 49/16 (20130101) H01J 49/20 (20130101) H01J 49/24 (20130101) H01J 49/025 (20130101) H01J 49/30 (20130101) H01J 49/067 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093484 | HERRAULT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Florian G. HERRAULT (Agoura Hills, California); Chia-Ming CHANG (Agoura Hills, California) |
| ABSTRACT | An electronic assembly including: (a) wafer defining at least one cavity; (b) a chip disposed in the cavity; and (c) a metal heat spreader disposed in the cavity, the chip being embedded in the metal heat spreader; wherein the metal heat spreader has at least one elongate microstructure separated from a remainder of the metal heat spreader by at least one channel; wherein the metal heat spreader occupies an area within the cavity that is not occupied by the chip; and wherein the at least one elongate microstructure is configured and arranged in the cavity so as to improve thermal management of the chip by reducing stress across the chip as compared with a configuration and arrangement in which a heat spreader made of the metal and occupying the area within the cavity is a solid without channels. Also, a method for forming the electronic assembly. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345927 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/4882 (20130101) H01L 21/6835 (20130101) H01L 23/3672 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093530 | KIM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jinsang KIM (Ann Arbor, Michigan); Parag Deotare (Ann Arbor, Michigan); Da Seul Yang (Ann Arbor, Michigan); Che-Hsuan Cheng (Ann Arbor, Michigan) |
| ABSTRACT | An anti-tamper module includes a substrate and a photoisomerization (PI) layer formed on the substrate. The PI layer comprises molecules configured to transition from a first state to a second state in response to exposure to a first type of light and transition from the second state to the first state in response to exposure to a second type of light, and transitioning a selected portion of the PI layer to the first state while surrounding portions of the PI layer remain in the second state causes physical deformation of the PI layer. An excitonic layer is arranged on the PI layer. An electrical characteristic of the excitonic layer is sensitive to strain caused by the physical deformation of the PI layer such that an excitonic property of the excitonic layer changes in a region corresponding to the selected portion of the PI layer. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/471799 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/573 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093823 | PRINEAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (IOWA CITY, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JOHN P. PRINEAS (IOWA CITY, Iowa); DENNIS NORTON (IOWA CITY, Iowa); THOMAS F. BOGGESS (IOWA CITY, Iowa); RUSSELL J. RICKER (CORALVILLE, Iowa) |
| ABSTRACT | A method and a device for cascading broadband emission is described. The device may comprise a substrate, a bottom contact layer above at least a portion of the substrate, and a plurality of emission regions above the bottom contact layer. The plurality of emission regions may be disposed one above another. Each of the plurality of emission regions may be configured with different respective bandgaps to emit radiation of different wavelengths. The device may comprise a plurality of tunnel junctions and a top contact layer above the plurality of emission regions. The plurality of emission regions may comprise a W-superlattice comprising an electron-well layer, a hole-well layer and an electron confinement layer. Semiconductor layers of the W-superlattice may include AlAsSb, InAs, InGaSb, and InAs. Exemplary embodiments of the W-superlattice may comprise a W-quantum well. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539260 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 33/06 (20130101) Original (OR) Class H01L 33/30 (20130101) H01L 33/0062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220094305 | Tang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (CLEVELAND, Ohio) |
| ASSIGNEE(S) | VIRTUAL EM INC. (Ann Arbor, Michigan) |
| INVENTOR(S) | Xinyao Tang (Cleveland Heights, Ohio); Soumyajit Mandal (Gainesville, Florida); Tayfun Ozdemir (Ann Arbor, Michigan) |
| ABSTRACT | An example sensing system includes a non-contact sensing electrode configured to sense an electric potential and provide a sensor signal at an output of the sensing electrode based on the sensed electric potential. The output of the sensing electrode is coupled to a first input of an amplifier. The amplifier is configured to provide an amplified output signal representative of at least one measured biosignal based on the sensor signal and a feedback signal provided to the second input of the amplifier. A compensation signal generator is coupled between the output of the amplifier and the second input. The compensation signal generator is configured to estimate corresponding noise and provide the feedback signal to include a filtered signal representative of the estimated noise to the second input to the corresponding noise at the first input of the amplifier and mitigate saturation of the amplifier. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/481574 |
| CURRENT CPC | Amplifiers H03F 1/26 (20130101) H03F 1/0266 (20130101) Original (OR) Class H03F 1/3288 (20130101) H03F 2200/171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220094512 | KOLODZIEJ |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth E. KOLODZIEJ (Lexington, Massachusetts) |
| ABSTRACT | A system for canceling signal interference (SI) includes a transceiver configured to concurrently transmit signals and receive signals within a single frequency band, which causes signal interference between the transmitted and received signals. The SI canceller is configured to use a set of cancellation coefficients to generate a cancellation signal to mitigate the SI. The system is configured to iteratively change the cancellation coefficients by a step factor to produce tuned cancellation coefficients. The step factor is determined by a cancellation error gradient and one or more of: a tunable coefficient step aggressiveness factor; and a time-based forgetting factor; and cause the SI canceller to cancel the SI using the tuned cancellation coefficients. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186894 |
| CURRENT CPC | Transmission H04B 1/1081 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 5/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220094861 | Gruev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viktor Gruev (Champaign, Illinois); Nimrod Missael Garcia Hernandez (Urbana, Illinois) |
| ABSTRACT | A multispectral imaging sensor includes at least one superpixel including a plurality of pixels. Each pixel includes an imaging element, and each imaging element includes at least one photodetector. Each pixel further includes a spectral filter associated with the imaging element. The spectral filter permits light to pass to its associated imaging element only within a plurality of passbands. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/457955 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 5/332 (20130101) Original (OR) Class H04N 9/04553 (20180801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220095017 | Eberle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NVIDIA Corp. (Santa Clara, California) |
| ASSIGNEE(S) | NVIDIA Corp. (Santa Clara, California) |
| INVENTOR(S) | Hans Eberle (Mountain View, California); Larry Robert Dennison (Mendon, Massachusetts) |
| ABSTRACT | A communication method between a source device and a target device utilizes speculative connection setup between the source device and the target device, target-device-side packet ordering, and fine-grained ordering to remove packet dependencies. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539947 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/20 (20130101) H04L 45/7453 (20130101) H04L 47/283 (20130101) H04L 47/624 (20130101) Pictorial Communication, e.g Television H04N 21/2387 (20130101) H04N 21/4302 (20130101) H04N 21/6583 (20130101) H04N 21/23406 (20130101) H04N 21/47217 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220088163 | BLAKE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tim R. BLAKE (Palo Alto, California); Robert M. WAYMOUTH (Palo Alto, California); Paul WENDER (Palo Alto, California); Ronald LEVY (Palo Alto, California); Ole Audun Werner HAABETH (Palo Alto, California); Matthew FRANK (Palo Alto, California); Adrienne SALLETS (Palo Alto, California) |
| ABSTRACT | There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo. |
| FILED | Monday, November 11, 2019 |
| APPL NO | 17/292370 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001112 (20180801) Original (OR) Class A61K 47/6935 (20170801) A61K 2039/545 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) A61K 2039/6025 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088868 | DUOSS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric B. DUOSS (Danville, California); James OAKDALE (Castro Valley, California); Nicholas Anthony RODRIGUEZ (Austin, Texas); Hongtao SONG (Austin, Texas); Richard CRAWFORD (Austin, Texas); Carolyn SEEPERSAD (Austin, Texas); Morgan CHEN (Richardson, Texas) |
| ABSTRACT | The present disclosure relates to a tensioning system for use in a stereolithography manufacturing application. The system may have a build plate for supporting a three dimensional part being formed using a photo responsive resin, a base plate and a release element extending over the base plate. The release element is configured to receive a quantity of photo responsive resin for forming a new material layer of the three dimensional part. A pair of tensioning components are secured to opposite ends of the release element, and apply a controlled tension force to the release element during peeling of the release element to reduce a separation force required to separate the release element from the new material layer after the new material layer is cured. |
| FILED | Tuesday, September 22, 2020 |
| APPL NO | 17/028543 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/214 (20170801) B29C 64/245 (20170801) Original (OR) Class B29C 64/264 (20170801) B29C 64/393 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2901/12 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088876 | Ivanov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilia N. Ivanov (Knoxville, Tennessee); Eric S. Muckley (San Diego, California) |
| ABSTRACT | An additive manufacturing system comprising at least one electronic nose (e-nose) is provided. The e-nose may comprise a housing and gas sensors. The housing may have an air channel. The active sensor portion of the sensors are positioned in the air channel. The housing may be mounted to an extruder head of an additive manufacturing device. The system may also comprise a processor. The processor may determine whether there is an abnormality in an additive manufacturing process based on one or more combinations of outputs from the gas sensors received during the additive manufacturing process input into a deployed machine learning model; and generate a report for the additive manufacturing process containing the determination. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/483170 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/364 (20170801) B29C 64/386 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088881 | Kim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seokpum Kim (Knoxville, Tennessee); Ahmed A. Hassen (Knoxville, Tennessee); John M. Lindahl (Knoxville, Tennessee); Lonnie J. Love (Knoxville, Tennessee); Vlastimil Kunc (Knoxville, Tennessee); Thomas Feldhausen (Knoxville, Tennessee) |
| ABSTRACT | A simulation-assisted additive manufacturing system and method for generating an anisotropic compensation to account for non-uniform deformation due to additive manufacturing and service loading. The predicted deformation may not be fully defined. The present disclosure provides a system and method for estimating the missing deformation data through regression analysis. The present disclosure also provides an integrated framework where the various simulated-assisted design modules are configured for two-way communication and sharing access to changes to the model. |
| FILED | Wednesday, September 15, 2021 |
| APPL NO | 17/475512 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/236 (20170801) B29C 64/393 (20170801) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089483 | Jackson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Marie D. Jackson (Salt Lake City, Utah); Philip F. Brune (Parkland, Florida); Thomas Adams (Reno, Nevada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marie D. Jackson (Salt Lake City, Utah); Philip F. Brune (Parkland, Florida); Thomas Adams (Reno, Nevada) |
| ABSTRACT | The described systems, methods, and compositions relate to systems, methods, and compositions for forming one or more cementitious materials that cure into one or more mortars and/or concretes. More particularly, some embodiments relate to systems, methods, and compositions for forming cured mortars and/or concretes that tend to have an increased strength over time due to the use of one or more reactive aggregates, activator materials, and/or alkaline compounds for conditioning the aggregate. In some cases, a cementitious mixture that is configured to form a mortar that can receive one or more filler aggregates (e.g., reactive filler aggregates) to make a concrete. Additionally, in some cases, the reactive aggregate is conditioned with an aqueous solution comprising one or more alkaline compounds having a concentration in the aqueous solution of between about 0.001 mol/L and about 10 mol/L, or within any subrange thereof (e.g., between about 0.25 molar and about 5 molar). |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/483520 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 7/12 (20130101) Original (OR) Class C04B 22/064 (20130101) C04B 22/0093 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089654 | JOHNSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher W. JOHNSON (Denver, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); Isabel PARDO MENDOZA (Dos Hermanas, Spain); Ellen Lee NEIDLE (Dacula, Georgia) |
| ABSTRACT | The present disclosure relates to a non-naturally occurring microorganism that includes a gene encoding a MucK transporter protein, where the microorganism is capable of catabolizing terephthalic acid (TPA). In some embodiments of the present disclosure, the gene encoding the MucK transporter protein may contain at least one mutation, relative to a reference gene encoding a reference MucK transporter protein. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/472936 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091032 | Wessel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Frank Joseph Wessel (Irvine, California); Fernando Brandi (Genova, Italy) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank Joseph Wessel (Irvine, California); Fernando Brandi (Genova, Italy) |
| ABSTRACT | An interferometer having a fundamental beam generator, a first second harmonic generator, a waveplate, a second second harmonic generator, a harmonic separator, and a polarizing beam splitter, mounted uniaxially, (i.e., the components are aligned along one optical axis), wherein the interferometer is adapted to change a diameter of a beam to match a diameter of a sample, and to change the diameter of the beam back to its original diameter. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/457237 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02 (20130101) G01B 9/02001 (20130101) G01B 9/02011 (20130101) G01B 9/02012 (20130101) G01B 9/02024 (20130101) G01B 9/02097 (20130101) G01B 11/0675 (20130101) G01B 2290/70 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/45 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091064 | Gervasio et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominic Francis Gervasio (Tucson, Arizona); Kalin Danton (Tucson, Arizona); Gil-Pyo Kim (Tucson, Arizona); Vlad Alex Sasaran (Tucson, Arizona); Nicholas Michael McEvoy (Tucson, Arizona); Alexis Gary (Tucson, Arizona) |
| ABSTRACT | This present disclosure is directed to a silver metal wire coated with silver sulfide reference electrode, the preparation via anodization of a silver metal wire in a sodium and/or potassium sulfide solution and use thereof, including test methods to measure corrosion in test articles such as metal pipes. The reference electrode exhibits good stability characteristics, including stability under high temperature conditions. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/461771 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 11/34 (20130101) Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 7/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 17/02 (20130101) G01N 27/48 (20130101) G01N 27/301 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091081 | Ivanov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilia N. Ivanov (Knoxville, Tennessee); Eric S. Muckley (San Diego, California); Reinaldo C. Reina (Brooklyn, Maryland) |
| ABSTRACT | A system for determining an age and/or quality of food or beverage based on one or more combinations of outputs from gas sensors input into a deployed machine learning model is provided. The system may comprise an electronic nose which may comprise a housing and the gas sensors. The housing may have an air channel. Each sensor has its active sensor portion in the air channel. A system for predicting one or more natural language descriptors associated with aromas of an item based on one or more outputs of the gas sensors and calculated one or more ratios input into a logistic regression model is also provided. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/483187 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0001 (20130101) Original (OR) Class G01N 33/02 (20130101) Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 5/022 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091083 | Ivanov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilia N. Ivanov (Knoxville, Tennessee); Eric S. Muckley (San Diego, California); Nicholas West (Knoxville, Tennessee) |
| ABSTRACT | A system for predicting one or more analytes based on outputs from thin film gas sensors is provided. The system may comprise an electronic nose (e-nose). The e-nose may comprise the gas sensors and a first processor. The system may further comprise a second processor. The second processor may be configured to receive the output from each of the gas sensors, evaluate a prediction accuracy using an evaluation parameter of each of a plurality of models which are trained and tested and select a model from among the plurality of models to deploy based on a comparison of the evaluation parameter for each of the plurality of models and use the same. The second processor may also receive, an output of each of the gas sensors caused by unknown one or more analytes; and predict, using the deployed model, the one or more analytes that causes the output. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/483153 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/0816 (20130101) A61B 5/6891 (20130101) A61B 2562/046 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0031 (20130101) Original (OR) Class G01N 33/0063 (20130101) G01N 33/0073 (20130101) G01N 33/497 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091099 | Sharei et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Armon R. Sharei (Cambridge, Massachusetts); Marc Lajoie (Seattle, Washington); Klavs F. Jensen (Lexington, Massachusetts); Robert S. Langer (Newton, Massachusetts) |
| ABSTRACT | Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described. |
| FILED | Tuesday, August 17, 2021 |
| APPL NO | 17/404286 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5002 (20130101) Original (OR) Class G01N 33/48721 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091174 | Karin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd Karin (Los Gatos, California); Peter Kiesel (Palo Alto, California); Ajay Raghavan (Mountain View, California) |
| ABSTRACT | A partial discharge (PD) transducer that includes a PD sensor configured to sense a PD event of an electrical system. At least one light emitting device (LED) is arranged in series with the PD sensor. The LED is configured to receive the electrical sensor signal from the PD sensor and to generate a light signal in response to the electrical sensor signal. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/538441 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 15/16 (20130101) G01R 15/22 (20130101) G01R 19/0084 (20130101) G01R 31/1218 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091288 | Derenzo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen Derenzo (Pinole, California); Edith Bourret (Berkeley, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to neutron detection and gamma ray detection. In one aspect, a detector comprises a scintillator structure that comprises an organic scintillator and an inorganic scintillator. The organic scintillator is in the form of one or more elements of a specified length. The inorganic scintillator is in the form of one or more elements of the specified length. First ends of the one or more organic scintillator elements and first ends of the one or more inorganic scintillator elements define a first surface. Second ends of the one or more organic scintillator elements and second ends of the one or more inorganic scintillator elements define a second surface. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474256 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 3/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091446 | Cheung et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanley Cheung (Milpitas, California); Di Liang (Santa Barbara, California); Sudharsanan Srinivasan (Santa Barbara, California) |
| ABSTRACT | Examples described herein relate to an optical coupler. The optical coupler may include a first optical waveguide base layer, a second optical waveguide base layer, an insulating layer disposed over at least a portion of both the first optical waveguide base layer and the second optical waveguide base layer, and a semiconductor material layer disposed over the insulating layer. Overlapping portions of the first optical waveguide base layer, the insulating layer, and the semiconductor material layer form a first optical waveguide, and overlapping portions of the second optical waveguide base layer, the insulating layer, and the semiconductor material layer form a second optical waveguide. Moreover, the optical coupler may include a plurality of metal contacts to receive one or more first biasing voltages to operate one of the first optical waveguide base layer and the second optical waveguide base layer in an accumulation mode. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 16/948579 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/025 (20130101) Original (OR) Class G02F 2001/0152 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091571 | Ivanov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ilia N. Ivanov (Knoxville, Tennessee); Eric S. Muckley (San Diego, California) |
| ABSTRACT | An integrated multifunctional environmental characterization system (IMECS) is provided. The IMECS may comprises a memory, one or more interfaces and a processor. The processor may be configured to predict an environment condition adjacent to a thin film using one or more machine learned models from one or more measured properties of the thin film received via the one or more interfaces; and/or predict values for one or more properties of the thin film using the one or more machine learned models from an environmental condition received via one of the one or more interfaces; and display the predicted environment condition and/or the predicted one or more properties. The processor may also adjust the acquisition parameters used to acquire values of one or more properties of the thin film from received acquisition parameters via a user interface based on measured values for the same properties. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/483226 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/00 (20130101) G01N 21/25 (20130101) G01N 27/026 (20130101) G01N 2203/0094 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/042 (20130101) Original (OR) Class G05B 2219/2614 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091844 | Cai et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Drexel University (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Yuanfang Cai (Paoli, Pennsylvania); Frederick Kazman (Pittsburgh, Pennsylvania); Hongzhou Fang (Philadelphia, Pennsylvania) |
| ABSTRACT | The method and system is called I-FAR: Interactive, Facet-based Architecture Recovery. Inspired by the idea that each system feature, pattern, or concern may have its own design space, the method defines a “facet” as a set of files that have one primary purpose, such as the implementation of a feature or the management of a cross-cutting concern such as performance, security, logging, etc. |
| FILED | Monday, August 02, 2021 |
| APPL NO | 17/391186 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/74 (20130101) G06F 8/75 (20130101) Original (OR) Class G06F 8/433 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091880 | Dutu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| INVENTOR(S) | Alexandru Dutu (Bellevue, Washington); Marcus Nathaniel Chow (San Diego, California); Matthew D. Sinclair (Bellevue, Washington); Bradford M. Beckmann (Bellevue, Washington); David A. Wood (Austin, Texas) |
| ABSTRACT | Techniques for executing workgroups are provided. The techniques include executing, for a first workgroup of a first kernel dispatch, a workgroup dependency instruction that includes an indication to prioritize execution of a second workgroup of a second kernel dispatch, and in response to the workgroup dependency instruction, dispatching the second workgroup of the second kernel dispatch prior to dispatching a third workgroup of the second kernel dispatch, wherein no workgroup dependency instruction including an indication to prioritize execution of the third workgroup has been executed. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/031424 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/545 (20130101) G06F 9/3838 (20130101) G06F 9/4881 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091980 | Kayiran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Micro Devices, Inc. (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Onur Kayiran (Santa Clara, California); Yasuko Eckert (Bellevue, Washington); Mark Henry Oskin (Bellevue, Washington); Gabriel H. Loh (Bellevue, Washington); Steven E. Raasch (Austin, Texas); Maxim V. Kazakov (San Diego, California) |
| ABSTRACT | A system and method for efficiently processing memory requests are described. A computing system includes multiple compute units, multiple caches of a memory hierarchy and a communication fabric. A compute unit generates a memory access request that misses in a higher level cache, which sends a miss request to a lower level shared cache. During servicing of the miss request, the lower level cache merges identification information of multiple memory access requests targeting a same cache line from multiple compute units into a merged memory access response. The lower level shared cache continues to insert information into the merged memory access response until the lower level shared cache is ready to issue the merged memory access response. An intermediate router in the communication fabric broadcasts the merged memory access response into multiple memory access responses to send to corresponding compute units. |
| FILED | Thursday, September 24, 2020 |
| APPL NO | 17/031706 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/3037 (20130101) G06F 12/084 (20130101) G06F 12/0811 (20130101) Original (OR) Class G06F 12/0877 (20130101) G06F 13/1668 (20130101) G06F 2212/1021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220092390 | RACKAUCKAS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Julia Computing, Inc. (Newton, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher RACKAUCKAS (Newton, Massachusetts); Viral B. SHAH (Newton, Massachusetts); Yingbo MA (Newton, Massachusetts) |
| ABSTRACT | Systems and methods of component-based modeling using trained surrogates are disclosed. A component architecture is made up of composable subsystem components. The composable subsystem components are reusable, such that the subsystem components are trained, and a library of trained model-reduced forms is created, which allows for large-scale models to be automatically accelerated for modeling. In this way, complex models are built by stitching together pre-designed, pre-shrunk components consisting of self-contained systems. A novel combination of using surrogates for modeling purposes and accelerated solving is provided to create an architecture that simulates complex physical processes that were previously infeasible to simulate in a commercially reasonable time. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/491823 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220092609 | Giera et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian Giera (San Mateo, California); Kerry G. Krauter (Livermore, California); Brian Matthew Wihl (Pleasanton, California); Michael E. Zelinski (Oakland, California) |
| ABSTRACT | A system for evaluating the effectiveness of an anti-counterfeiting measure employed for an item is provided. The system trains a classifier to indicate whether the anti-counterfeiting measure of an evaluation item is genuine or counterfeit. For evaluation items that have been classified as genuine or counterfeit, the system applies the classifier to determine whether the anti-counterfeiting measure of that evaluation item is genuine or counterfeit. The system then generates an effectiveness metric that indicates whether the anti-counterfeiting measure is effective based on evaluation items that are assessed as being genuine whose anti-counterfeiting measures are classified as being counterfeit. |
| FILED | Tuesday, September 22, 2020 |
| APPL NO | 17/028897 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00671 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0185 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093283 | Brown et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Michael A. Brown (Chicago, Illinois); Jerry A. Nolen, JR. (Chciago, Illinois); Walter F. Henning (St. Charles, Illinois); David A. Rotsch (Montgomery, Illinois); Sergey D. Chemerisov (Lisle, Illinois); Jeongseog Song (Lisle, Illinois) |
| ABSTRACT | The invention provides a method for generating medical isotopes, the method comprising contacting a primary radiation beam with a converter for a time sufficient to produce a secondary beam of gamma particles, and contacting the beam of gamma particles to a target, where the cross section dimension of the beam of gamma particles is similar to the cross section dimension of the target. Both the converter and target are small in diameter and very closely spaced. Also provided is a system for producing medical isotopes, the device comprising a housing having a first upstream end and a second downstream end, a radiotransparent channel (collimator) with a first upstream end and a downstream end, wherein the upstream end is adapted to receive a radiation beam, a target positioned downstream of the downstream end of the channel and coaxially aligned with the channel, wherein the target has a cross section that is similar to the cross section of the channel. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544843 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 1/001 (20130101) G21G 1/10 (20130101) Original (OR) Class G21G 2001/0084 (20130101) G21G 2001/0089 (20130101) G21G 2001/0094 (20130101) Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 5/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093296 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian-Ping WANG (Shoreview, Minnesota); YanFeng JIANG (Minneapolis, Minnesota) |
| ABSTRACT | A permanent magnet may include a Fe16N2 phase in a strained state. In some examples, strain may be preserved within the permanent magnet by a technique that includes etching an iron nitride-containing workpiece including Fe16N2 to introduce texture, straining the workpiece, and annealing the workpiece. In some examples, strain may be preserved within the permanent magnet by a technique that includes applying at a first temperature a layer of material to an iron nitride-containing workpiece including Fe16N2, and bringing the layer of material and the iron nitride-containing workpiece to a second temperature, where the material has a different coefficient of thermal expansion than the iron nitride-containing workpiece. A permanent magnet including an Fe16N2 phase with preserved strain also is disclosed. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/543863 |
| CURRENT CPC | Alloys C22C 38/001 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 8/02 (20130101) C23C 8/18 (20130101) C23C 8/24 (20130101) C23C 8/26 (20130101) C23C 8/60 (20130101) C23C 8/80 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/047 (20130101) Original (OR) Class H01F 1/0063 (20130101) H01F 41/0253 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093306 | Ketterson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John B. Ketterson (Evanston, Illinois); Anupam K. Garg (Wilmette, Illinois); Jinho Lim (Evanston, Illinois); Zhaohui Zhang (Oak Park, Illinois) |
| ABSTRACT | Systems and methods for reversing a magnetization in a ferromagnet include a nanometer-scale cylindrical ferromagnetic sample having a height to diameter aspect ratio on the order of 2 or greater. A temporally-varying external field comprising an r.f. Pi pulse is applied to the ferromagnetic sample to cause a precession magnetization vector inclined at an angle with respect to the longest axis of the ferromagnetic sample to continuously rotate around the longest axis. One or more parameters of the temporally-varying external field is continuously adjusted based on at least magnetization dynamics of the ferromagnetic sample and/or an angular dependence of a precession frequency of the ferromagnetic sample. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/483405 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 13/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093904 | Tucker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Michael Tucker (Piedmont, California); Fengyu Shen (San Leandro, California) |
| ABSTRACT | Compositions and methods for the fabrication of electrode and porous lithium-garnet electrolyte scaffolds for use in solid state batteries and other devices are provided. The methods produce porous structures using phase inversion or high shear compaction processes to fabricate a solid-state battery electrode material from LLZO electrolytes. Engineered electrode structures with a porous scaffold of solid electrolyte material provide lower interfacial resistances and a mechanical support for a thin solid electrode layer improving performance. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/478509 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/131 (20130101) Original (OR) Class H01M 4/664 (20130101) H01M 4/801 (20130101) H01M 10/058 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093935 | ABDUL JABBAR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland) |
| INVENTOR(S) | Mohammed Hussain ABDUL JABBAR (Farmington Hills, Michigan); Eric D. WACHSMAN (Fulton, Maryland) |
| ABSTRACT | The present disclosure provides a stable ceramic anode for a solid oxide fuel cell (SOFC) and a method for producing and using the same. In particular, anodes for solid oxide fuel cells disclosed herein can be operated at a significantly lower temperature than conventional SOFCs, and allow thermal and anode gas cycling under transient conditions. More significantly, anodes described in the present disclosure have a significantly higher long-term operability compared to a similar anode having a higher amount of electrocatalyst. In one particular embodiment, the stable ceramic anodes comprise (i) strontium-iron-cobalt-molybdenum oxide (SFCM) material; (ii) a first ion-conductor composition comprising an oxide of cerium or cerium that is doped with a rare-earth metal; and (iii) nanoparticles of an electrocatalyst comprising (a) a second ion-conductor and (b) nickel, a nickel alloy, or a combination thereof. The amount of electrocatalyst in said stable ceramic anode is less than 10 wt %. |
| FILED | Monday, September 20, 2021 |
| APPL NO | 17/479654 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/8621 (20130101) Original (OR) Class H01M 4/9033 (20130101) H01M 8/12 (20130101) H01M 2004/8684 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093960 | Jonson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Robert Jonson (Berkeley, California); Michael Tucker (Piedmont, California) |
| ABSTRACT | Slurry compositions, tape casting binder systems and fabrication methods for the fabrication of lithium-garnet electrolyte scaffolds for use in solid state batteries and other devices are provided. Slurry compositions may be optimized mixtures of LLZO powder, a dispersant, a lithium salt, a wetting agent a binder, a plasticizer and at least one solvent. The optimized ceramic slurry compositions may include MgO as a sintering additive to improve density and ionic conductivity of the doped-LLZO sheets and produce a fine-grained microstructure. Sintering protocols for cast slurries of commercially available doped LLZO powders eliminate the requirement of mother-powder coverings or externally applied pressure. An environmentally friendly water-based system using methylcellulose as a binder is also provided producing green tape and final properties comparable to those obtained with organic solvent-based systems. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/480855 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/056 (20130101) Original (OR) Class H01M 10/058 (20130101) H01M 2300/002 (20130101) H01M 2300/0088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093967 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Hui Wang (Louisville, Kentucky); Yang Li (Louisville, Kentucky); Thad Druffel (Louisville, Kentucky) |
| ABSTRACT | Methods for wet chemical synthesis of lithium argyrodites are provided, which in some embodiments include dissolving a stoichiometric mixture of precursors in a small quantity of solvent in an argon atmosphere, drying the mixture under vacuum or an inert gas atmosphere to evaporate the solvent, and then annealing to obtain a final lithium argyrodite product. Further embodiments comprise synthesizing the precursors, excess halide doping to achieve higher ionic conductivity, and the use of carboxylic acid esters to enhance the interfacial properties of high-performance lithium batteries. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544279 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0562 (20130101) Original (OR) Class H01M 2300/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220094013 | Paiss |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Matthew D. Paiss (Soquel, California) |
| ABSTRACT | A system including a container defining a chamber in which an energy storage device is housed contains openings in the sides of the container dimensioned to be covered with doors connected to opening mechanisms that open the door when a latching mechanism is released as a result of a signal received from any of a variety of sensors and take selected action based upon that preselected signal. Monitoring and selective opening of the doors to allow venting allows for preventing fires and explosions is enabled by such a system and device. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/483202 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/425 (20130101) H01M 50/375 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220094014 | Marr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Altect, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Altect, Inc. (Austin, Texas) |
| INVENTOR(S) | Kevin Marr (Austin, Texas); Paul Lee (Frisco, Texas) |
| ABSTRACT | Apparatus and associated methods relate to a neutralization and circulation module (NCM) configured to generate a combustion suppressant stream from a flammable intake stream. In an illustrative example, the NCM includes an intake port and an output port, each in fluid communication with a chamber containing (electro)chemical energy storage units capable of emitting combustible gases. The NCM may, for example, include a reactor in fluid communication between the intake and output port. The reactor may, for example, selectively apply an oxygen-containing stream from an oxygen source to the intake stream to generate, from the stream containing combustible gases, a combustion suppressant gas stream that is discharged through the output port into the chamber such that an upper flammability limit approaches a lower flammability limit in the chamber. Various embodiments may advantageously eliminate a flammable regime in a chemical energy storage environment. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/448260 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 50/143 (20210101) H01M 50/383 (20210101) Original (OR) Class H01M 2200/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220094220 | Islam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | North Carolina State University (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Md Sariful Islam (Raleigh, North Carolina); Iqbal Husain (Raleigh, North Carolina); Ritvik Chattopadhyay (Raleigh, North Carolina); Gregory D. Buckner (Raleigh, North Carolina) |
| ABSTRACT | Various examples are provided related to 3D airgap electric machines and winding embedded liquid cooling. In one example, an electric machine includes a stator assembly with stator windings supported by a stator core and an outer rotor assembly includes a radial plate surrounding the stator assembly and an endplate at a first end of the radial plate adjacent to the first end of the stator core. The stator windings can include a first portion extending along an axial length of the stator core and a second portion at a first end of the stator core that extends radially inward towards a shaft of the electric machine. The radial plate can include magnets distributed about the radial plate. In another example, a stator assembly includes stator windings supported by a stator core with a winding support including cooling channels distributed between the stator windings. The winding support can be nonmagnetic. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/482645 |
| CURRENT CPC | Dynamo-electric Machines H02K 1/16 (20130101) H02K 1/17 (20130101) H02K 1/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220094396 | Bhuyan |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Energy, United States Department of (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arupjyoti Bhuyan (Idaho Falls, Idaho) |
| ABSTRACT | A system and methods for selective transmission and reception for stationary wireless networks. The system and method include an end user equipment, a primary base station, a core network, and a selective server. The end user equipment transmits a request for transmission to the primary base station receiver. The primary base station authenticates the end user equipment using a cellular network authentication process. The primary base station then searches for a time slot data for the end user equipment from the selective server and determines whether the time slot is open for transmission, steers a beam towards the end user equipment when time slot is open for transmission. The primary base station then enables transmission from the end user equipment, wherein the enabling is performed by the primary base station. The core network receives the transmission from the end user equipment. |
| FILED | Tuesday, September 22, 2020 |
| APPL NO | 17/028005 |
| CURRENT CPC | Transmission H04B 7/043 (20130101) Original (OR) Class H04B 7/0617 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1466 (20130101) Wireless Communication Networks H04W 12/12 (20130101) H04W 12/00503 (20190101) H04W 12/00512 (20190101) H04W 72/046 (20130101) H04W 72/0446 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220087607 | Ganesan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deepak Ganesan (Amherst, Massachusetts); Trisha L. Andrew (Hadley, Massachusetts); Ali Kiaghadi (Amherst, Massachusetts); Seyedeh Zohreh Homayounfar (Amherst, Massachusetts); Jeremy Gummeson (Belchertown, Massachusetts) |
| ABSTRACT | A garment system comprises a garment substrate formed from one or more textile-based sheets, a distributed array of a plurality of resistive pressure sensors coupled to the garment substrate at a set of first specified locations. Each of the plurality of resistive sensors comprises a pair of first textile-based outer layers each having an electrical resistance of no more than 100 ohms and a textile-based inner layer sandwiched between the pair of first textile-based outer layers having an electrical resistance of at least 1 mega-ohm. The system also includes electronics configured to process signals from the distributed array of resistive pressure sensors to determine one or more physiological properties of a wearer of the garment substrate. |
| FILED | Tuesday, March 31, 2020 |
| APPL NO | 17/593940 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 1/005 (20130101) A41D 31/04 (20190201) Diagnosis; Surgery; Identification A61B 5/1102 (20130101) A61B 5/1116 (20130101) A61B 5/6804 (20130101) Original (OR) Class A61B 5/6823 (20130101) A61B 2562/0247 (20130101) Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/08 (20130101) B32B 5/024 (20130101) B32B 5/26 (20130101) B32B 7/025 (20190101) B32B 2250/20 (20130101) B32B 2255/02 (20130101) B32B 2255/26 (20130101) B32B 2255/205 (20130101) B32B 2262/062 (20130101) B32B 2262/0261 (20130101) B32B 2307/73 (20130101) B32B 2307/202 (20130101) B32B 2307/204 (20130101) B32B 2307/206 (20130101) B32B 2437/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088163 | BLAKE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tim R. BLAKE (Palo Alto, California); Robert M. WAYMOUTH (Palo Alto, California); Paul WENDER (Palo Alto, California); Ronald LEVY (Palo Alto, California); Ole Audun Werner HAABETH (Palo Alto, California); Matthew FRANK (Palo Alto, California); Adrienne SALLETS (Palo Alto, California) |
| ABSTRACT | There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo. |
| FILED | Monday, November 11, 2019 |
| APPL NO | 17/292370 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001112 (20180801) Original (OR) Class A61K 47/6935 (20170801) A61K 2039/545 (20130101) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) A61K 2039/6025 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088226 | PURSE et al. |
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| FUNDED BY |
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| APPLICANT(S) | San Diego State University Foundation (San Diego, California) |
| ASSIGNEE(S) | San Diego State University Foundation (San Diego, California) |
| INVENTOR(S) | Byron W. PURSE (San Diego, California); George SAMAAN (San Diego, California); Mckenzie WYLLIE (San Diego, California); Julian CIZMIC (San Diego, California); Katrina NGO (San Diego, California); Susan ANDERSEN (San Diego, California) |
| ABSTRACT | Fluorescent nucleobase surrogates capable of Watson-Crick hydrogen bonding are essential probes of nucleic acid structure and dynamics. Their limited brightness and short absorption and emission wavelengths have rendered them unsuitable for single-molecule detection. Herein, we synthesized a new tricyclic pyrimidine nucleoside analogue with a push-pull conjugated system. The resulting C-linked 8-(diethylamino)benzo[b][1,8] naphthyridin-2(1H)-one nucleoside (ABN), exhibits ε442=20,000 M−1 cm−1 and Φem,540=0.39 in water, increasing to Φem=0.50-0.53 when base paired with adenine in duplex DNA oligonucleotides. Single-molecule fluorescence measurements of ABN using both one-photon and two-photon excitation demonstrate its excellent photostability and indicate that the nucleoside is present to >95% in a bright state with count rates of at least 15 kHz per molecule. This new fluorescent nucleobase analogue, which, in duplex DNA, is the brightest and most red-shifted known, is first to offer robust single-molecule fluorescence detection capabilities. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 17/476852 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0021 (20130101) Original (OR) Class Heterocyclic Compounds C07D 471/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/6561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088228 | Steinmetz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (CLEVELAND, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole Steinmetz (San Diego, California); Michael Bruckman (Cleveland, Ohio) |
| ABSTRACT | A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335557 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/1884 (20130101) A61K 49/1896 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2770/00031 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088555 | Shull et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth R. Shull (Evanston, Illinois); Yaoyao Chen (Evanston, Illinois) |
| ABSTRACT | A thermothickening fluid is provided which comprises a liquid phase; a first polymer comprising functional groups and having a room temperature solubility in the liquid phase; and a second, different polymer comprising functional groups and having a room temperature solubility in the liquid phase, wherein functional groups on the first polymer are capable of associating with functional groups on the second polymer to form complexes, and the room temperature solubility of the first polymer is greater than the room temperature solubility of the second polymer. The fluid is a colloid at room temperature, a solution at an elevated temperature, and exhibits a thermothickening/thinning transition viscosity value at a thermo-thickening/thinning transition temperature between room temperature and the elevated temperature. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/420952 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0082 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 33/02 (20130101) C08L 39/08 (20130101) C08L 2201/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088556 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daeyeon Lee (Wynnewood, Pennsylvania); Kathleen J. Stebe (Penn Valley, Pennsylvania); Sarah D. Hann (Yardley, Pennsylvania) |
| ABSTRACT | In one aspect of the invention, a microcapsule includes a film encapsulating a material. The film is formed by complexation of at least two mutually attractive components initially present in an aqueous dispersion comprising a continuous phase and a dispersed phase. The at least one first component is initially present in the continuous phase and the at least one second component is initially present in the dispersed phase. According to another aspect of the invention, provided is a process for forming microcapsules including the step of injecting a dispersed phase having at least a first component into a continuous phase having at least a second component, where the first component and the second component are mutually attractive, such that a film is formed by complexation of the first charged component and the second charged component. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/537840 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5031 (20130101) A61K 9/5036 (20130101) A61K 35/74 (20130101) A61K 2035/128 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/04 (20130101) B01J 13/10 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/04 (20130101) C12N 11/10 (20130101) C12N 11/082 (20200101) C12N 11/087 (20200101) C12N 11/089 (20200101) C12N 11/098 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088846 | Baer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Baer (Cleveland Heights, Ohio); Andy Olah (Spencer, Ohio); Zhenpeng Li (Shaker Heights, Ohio); Michael Hore (Shaker Heights, Ohio); Cong Zhang (Cleveland, Ohio) |
| ABSTRACT | A security marking has a physically unclonable function (PUF) wherein the PUF includes a disordered multilayer photonic crystal structure having an electromagnetic transmission and/or reflection spectrum and/or spectra upon receipt of electromagnetic radiation within a photonic bandgap region of the structure that is unique to the structure. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/543272 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 48/001 (20190201) Original (OR) Class B29C 48/08 (20190201) B29C 48/21 (20190201) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2105/0032 (20130101) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2007/008 (20130101) Books; Book Covers; Loose Leaves; Printed Matter Characterised by Identification or Security Features; Printed Matter of Special Format or Style Not Otherwise Provided For; Devices for Use Therewith and Not Otherwise Provided For; Movable-strip Writing or Reading Apparatus B42D 25/21 (20141001) B42D 25/45 (20141001) B42D 25/324 (20141001) B42D 25/328 (20141001) B42D 25/378 (20141001) B42D 25/382 (20141001) B42D 25/387 (20141001) Optical Elements, Systems, or Apparatus G02B 1/04 (20130101) G02B 5/1814 (20130101) G02B 2005/1804 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089487 | Burton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Marvin Burton (Glendale, Arizona); Christian Hoover (Chandler, Arizona); Elham Fini (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marvin Burton (Glendale, Arizona); Christian Hoover (Chandler, Arizona); Elham Fini (Phoenix, Arizona) |
| ABSTRACT | Treating plastic particles for use in concrete includes combining plastic particles with oil to yield a mixture, heating the mixture to yield a heated mixture, cooling the heated mixture to yield a cooled mixture, and removing excess oil from the cooled mixture to yield oil-treated plastic particles (e.g., oil-treated plastic particles for concrete). In one example, the oil is vegetable oil. The vegetable oil can be soybean oil, corn oil, canola oil, safflower oil, peanut oil, olive oil, grape seed oil, cocoa butter, palm oil, rice bran oil, or a combination thereof. The oil can be waste oil (e.g., waste vegetable oil, such as that recovered from restaurants). The plastic particles can be derived from post-consumer plastic, such as recycled plastic. In one example, the post-consumer plastic includes mixed plastics. A concrete composition can include rocks, sand, cement, and the oil-treated plastic particles. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484834 |
| CURRENT CPC | Disposal of Solid Waste B09B 3/0033 (20130101) B09B 3/0083 (20130101) Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 18/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089496 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ping Guo (Northfield, Illinois); Ange-Therese Akono (Evanston, Illinois); Yunzhi Xu (Evanston, Illinois) |
| ABSTRACT | Methods for the production of ceramic composites in which three-dimensional (3D) printed organic polymer fibers are embedded in an amorphous inorganic ceramic matrix are provided. The composites are made by electrospinning the organic polymer fibers and collecting them in a liquid or gel collector. Ceramic precursors added to the liquid collector after the fibers are collected, or present in the gel collector during the electrospinning, are then cured to form a solid ceramic matrix around the organic polymer fibers to produce an organic polymer fiber-reinforced ceramic. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/477892 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 16/0658 (20130101) C04B 28/008 (20130101) Original (OR) Class Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089508 | Koide et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kazunori Koide (Pittsburgh, Pennsylvania); James Proviano Burrows (West Homestead, Pennsylvania) |
| ABSTRACT | A method of reducing an aromatic ring or a cyclic, allylic ether in a compound includes preparing a reaction mixture including a compound including an aromatic moiety or a cyclic, allylic ether moiety, an alkali metal, and either ethylenediamine, diethylenetriamine, triethylenetetramine, or a combination thereof, in an ether solvent; and reacting the reaction mixture at from −20° C. to 30° C. for a time sufficient to reduce a double bond in the aromatic moiety to a single bond or to reduce the cyclic, allylic ether moiety. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/477900 |
| CURRENT CPC | General Methods of Organic Chemistry; Apparatus Therefor C07B 31/00 (20130101) Original (OR) Class Acyclic or Carbocyclic Compounds C07C 51/347 (20130101) C07C 67/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089537 | Koehler et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (, None); President and Fellows of Harvard College (, None) |
| INVENTOR(S) | Angela N. Koehler (Belmont, Massachusetts); Christina Woo (Cambridge, Massachusetts); Catherine Henry (Keswick, Virginia); Chia-Fu Chang (Cambridge, Massachusetts); Sebastian Pomplun (Cambridge, Massachusetts); Jasmin Kruell (Cambridge, Massachusetts); Brice Curtin (Cambridge, Massachusetts) |
| ABSTRACT | Organic compounds for target identification, drug discovery, chemical library production, high-throughput screening, fluorophore conjugation, chemiluminescent compound conjugation, creation of proximity induced modulators (e.g., protein degraders)/chimeric molecules, or a combination thereof are described. The compounds can contain small molecule moieties for identification of their potential targets; an isocyanate, photoactivatable groups; chemical moieties for enrichment and detection of target-small molecule moiety interactions; proximity induced modulator element; fluorophores; chemiluminescent groups; or combinations thereof. |
| FILED | Monday, July 12, 2021 |
| APPL NO | 17/373475 |
| CURRENT CPC | Heterocyclic Compounds C07D 203/04 (20130101) Original (OR) Class Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/04 (20130101) C40B 50/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089821 | OAKEY et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John OAKEY (Laramie, Wyoming); Benjamin NOREN (Laramie, Wyoming); Zhongliang JIANG (Laramie, Wyoming); Kun JIANG (Laramie, Wyoming) |
| ABSTRACT | Embodiments of the present disclosure generally relate to compositions comprising hydrogel-encapsulated/dispersed beta cells, compositions comprising hydrogel-encapsulated/dispersed beta-cell spheroids, processes for forming such compositions, and uses of the compositions. In an embodiment, a composition is provided that includes a first component comprising a hydrogel, the hydrogel comprising, in polymerized form, one or more photoreactive monomers and a thiol linker. The composition further comprises a second component comprising a plurality of beta cells dispersed or encapsulated within the hydrogel. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/482143 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/28 (20130101) C08J 3/075 (20130101) Original (OR) Class C08J 2333/02 (20130101) C08J 2371/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/37 (20130101) Compositions of Macromolecular Compounds C08L 33/02 (20130101) C08L 71/08 (20130101) C08L 2203/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0676 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090000 | OAKEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John OAKEY (Laramie, Wyoming); John KISIDAY (Fort Collins, Colorado); Benjamin NOREN (Laramie, Wyoming) |
| ABSTRACT | Embodiments of the present disclosure generally relate to apparatus for isolating biological material, processes for fabricating such apparatus, and processes for using such apparatus. In an embodiment, an apparatus for isolating a biological material is provided. The apparatus includes a fluidic channel disposed over a portion of a substrate. The apparatus further includes a hydrogel structure disposed in the fluidic channel, the hydrogel structure comprising a plurality of wells, wherein each well of the plurality of wells has a diameter from about 1 μm to about 500 μm, the hydrogel structure comprising, in polymerized form, one or more photoreactive monomers. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484381 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502761 (20130101) B01L 2200/12 (20130101) B01L 2200/0647 (20130101) B01L 2300/123 (20130101) B01L 2300/0829 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 47/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090026 | Steinmetz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicole F. Steinmetz (Cleveland, Ohio); Amy M. Wen (Cleveland, Ohio) |
| ABSTRACT | Virus particle multimers and methods of making and using such virus particle multimer are described. Virus particle multimers are constructed by preparing a plurality of asymmetrically functionalized virus particles bearing one or more functional groups and contacting the asymmetrically functionalized virus particles with a first linker molecule that reacts with the functional groups to form a virus particle multimer that includes a plurality of asymmetrically functionalized virus particles connected by the linker molecule. The asymmetrically functionalized virus particles are typically prepared by attaching the virus particles to a support surface to allow asymmetrical functionalization to be introduced. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544518 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2770/32023 (20130101) C12N 2770/32051 (20130101) C12N 2770/32142 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090027 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Han Li (Irvine, California); Justin B. Siegel (Davis, California); Youtian Cui (Davis, California); Wai Shun Mak (Davis, California) |
| ABSTRACT | Provided herein are engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and use of said polypeptides in engineered unnatural redox cofactor systems for whole-cell biomanufacturing and in cell-free applications. |
| FILED | Tuesday, December 10, 2019 |
| APPL NO | 17/297976 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/001 (20130101) C12N 9/0006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090139 | RAO et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Catholic University of America (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Venigalla B. RAO (Washington, District of Columbia); Jingen ZHU (Washington, District of Columbia) |
| ABSTRACT | Described is an “artificial virus” (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546183 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2795/00043 (20130101) C12N 2795/00051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090163 | Pierce et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Niles A Pierce (Pasadena, California); Harry M.T. Choi (Pasadena, California) |
| ABSTRACT | The present disclosure relates to methods and compositions involving HCR reactions that involve initiators that are split into two or more parts. Effective HCR is dependent upon two or more of these split initiators being brought into proximity (e.g., via binding events mediated by a target) such that a full initiator is formed that is capable of triggering HCR signal amplification. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/457572 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) Original (OR) Class C12Q 1/6816 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090200 | Horvath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); ILLUMINA, INC. (San Diego, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); ILLUMINA, INC. (San Diego, California) |
| INVENTOR(S) | Stefan Horvath (Los Angeles, California); Jason Ernst (Los Angeles, California); Adriana Cristina Arneson (Los Angeles, California); Bret Barnes (Carlsbad, California) |
| ABSTRACT | While methylation chips have been widely used in human studies over the last ten years, methylation chips for non-human species have not, perhaps due to lack of sufficient demand and/or because species specific methylation chips may be suboptimal for cross-species comparisons. To address challenges in this technology, we developed an algorithm, Conserved Methylation Array Probe Selector (CMAPS), which repurposes the degenerate base technology used to tolerate within-human variation to tolerate cross-species mutations. CMAPS performs a greedy search to obtain a maximal number of species that can be targeted using a probe for any CpG in the human genome, based on a multiple sequence alignment. CMAPS then ranks all the probes and chooses a final set so that arrays can be made that can query a large number of mammalian species and varied genomic positions based on external annotations of exons, CpG islands and hyper versus hypo methylated regions. |
| FILED | Monday, January 20, 2020 |
| APPL NO | 17/421573 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090300 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qihan Liu (Cambridge, Massachusetts); Kevin Kit Parker (Cambridge, Massachusetts); Huibin Chang (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for focused direction deposition of a micron or nanometer dimension polymeric fiber and materials of such fibers are described herein. Systems and methods employ one or more gas flows to entrain and deflect fibers produced by a rotary jet spinning system forming a focused fiber stream. Some embodiments enable control of alignment and distribution of the fibers with a relatively high fiber throughput. |
| FILED | Tuesday, January 14, 2020 |
| APPL NO | 17/421047 |
| CURRENT CPC | Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/14 (20130101) Original (OR) Class D01D 5/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090811 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Da LI (Clemson, South Carolina); Carol C. MENASSA (Ann Arbor, Michigan); Vineet KAMAT (Ann Arbor, Michigan) |
| ABSTRACT | A method of making a thermal comfort estimation of one or more human occupants in a built space in real-time is presented. The method employs one or more thermographic cameras and one or more red, green, and blue depth (RGB-D) sensors. The method has several steps. In an example, the method involves capturing thermal images of the human occupant(s) via the thermographic camera(s) and capturing RGB-D images of the human occupant(s) via the RGB-D camera(s). The method further involves extracting facial skin temperatures of the human occupant(s) using the captured thermal images and using the captured RGB-D images. And the method involves estimating the thermal comfort of the human occupant(s) using the extracted facial skin temperatures. |
| FILED | Thursday, January 09, 2020 |
| APPL NO | 17/422142 |
| CURRENT CPC | Arrangements of Heating, Cooling, Ventilating or Other Air-treating Devices Specially Adapted for Passenger or Goods Spaces of Vehicles B60H 1/00742 (20130101) Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 11/63 (20180101) Original (OR) Class F24F 2120/10 (20180101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 5/0025 (20130101) Image Data Processing or Generation, in General G06T 7/33 (20170101) G06T 2207/10024 (20130101) G06T 2207/10028 (20130101) G06T 2207/10048 (20130101) G06T 2207/30201 (20130101) G06T 2207/30232 (20130101) Image or Video Recognition or Understanding G06V 40/10 (20220101) Pictorial Communication, e.g Television H04N 5/247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090882 | Howell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRIGHAM YOUNG UNIVERSITY (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Larry L. Howell (Provo, Utah); Spencer P. Magleby (Provo, Utah); David C. Morgan (Provo, Utah); Terri Bateman (Provo, Utah); Jeffrey E. Niven (Provo, Utah); Alex Avila (Provo, Utah); Erica Crampton (Provo, Utah); Kyler Tolman (Provo, Utah); Jacob Greenwood (Provo, Utah); Peter Schleede (Provo, Utah) |
| ABSTRACT | An example barrier can be switchable between an at least partially collapsed state and at least partially expanded state (e.g., a deployed state). For example, the barrier can be formed from a continuous sheet and a plurality of rigid sections (e.g., rigid panels) attached or incorporated into the continuous sheet. The barrier can also include a plurality of hinges, such as hinge lines, between the panels that are formed from the continuous sheet. The hinges enable the barrier to be rigid foldable (e.g., the hinges can fold and unfold while the rigid sections remain stiff and rigid) between the expanded and collapsed states. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539436 |
| CURRENT CPC | Additional Work, Such as Equipping Roads or the Construction of Platforms, Helicopter Landing Stages, Signs, Snow Fences, or the Like E01F 13/02 (20130101) Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 9/06 (20130101) E06B 2009/007 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 5/04 (20130101) F41H 5/06 (20130101) Original (OR) Class F41H 5/013 (20130101) F41H 5/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091093 | WANUNU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts); Auburn University (Auburn, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Meni WANUNU (Needham, Massachusetts); Mehrnaz MOJTABAVI (Allston, Massachusetts); Armin VAHID MOHAMMADI (Auburn, Alabama); Majid BEIDAGHI (Auburn, Alabama) |
| ABSTRACT | The present technology provides a nanopore electrode sequencer for the characterization and sequencing of biomolecules. Two or more ultrathin MXene sheets containing nanopores serve as electrodes that bind and store cations which can be released to provide ionic current through the nanopore during sequencing, thereby eliminating access resistance to ions at the entrance to the nanopore from bulk solution. Resolution of ionic current changes caused by biopolymer components within the nanopore is thereby substantially improved, providing more sensitive and robust sequencing of biopolymers. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 17/424636 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/4473 (20130101) G01N 27/44791 (20130101) G01N 33/48721 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091624 | LUMB |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Polaris Semiconductor LLC (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew P. LUMB (Arlington, Virginia) |
| ABSTRACT | Disclosed is a linear voltage regulator with an input terminal, an output terminal, a pass device electrically connected to the input terminal and the output terminal, and an error amplifier that controls the output voltage at the output terminal by controlling the voltage drop across the pass device. The disclosed linear voltage regulator includes a light emitting section electrically connected in series with the pass device between the input terminal and the output terminal and a photovoltaic section, electrically connected to the output terminal, that receives photons emitted by the light emitting section and outputs a current to output terminal. The disclosed linear voltage regulator is more efficient than conventional linear voltage regulators because, unlike in those convention linear voltage regulators, the voltage drop across the pass device is only a fraction of the total potential difference between the input terminal and the output terminal. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198738 |
| CURRENT CPC | Systems for Regulating Electric or Magnetic Variables G05F 1/575 (20130101) Original (OR) Class Electric Heating; Electric Lighting Not Otherwise Provided for H05B 45/375 (20200101) H05B 45/395 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093380 | Xia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yu Xia (West Lafayette, Indiana); Zheng Ouyang (West Lafayette, Indiana); Xiaoxiao Ma (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to methods for analyzing a tissue sample. In certain aspects, the invention provides methods that involve obtaining a tissue sample including an unsaturated compound, conducting a radical reaction on the tissue sample that targets a carbon-carbon double bond within the unsaturated compound to thereby produce a plurality of compound isomers, subjecting the plurality of compound isomers to mass spectrometry analysis to identify a location of the carbon-carbon double bond within the unsaturated compound, and quantifying the plurality of compound isomers in order to distinguish normal tissue from diseased tissue. |
| FILED | Thursday, April 15, 2021 |
| APPL NO | 17/231224 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 10/0241 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 1/405 (20130101) G01N 30/00 (20130101) G01N 30/88 (20130101) G01N 30/7233 (20130101) G01N 33/92 (20130101) G01N 2030/8813 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 49/0004 (20130101) H01J 49/04 (20130101) H01J 49/0031 (20130101) H01J 49/0409 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093885 | Thomas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| INVENTOR(S) | Jayan Thomas (Orlando, Florida); Basudev Pradhan (Kolkata, India); Farzana Chowdhury (Orlando, Florida) |
| ABSTRACT | Techniques for growing, at least one of: (a) quantum dots and (b) nano-crystals, on a surface of a material are provided. One method comprises placing a precursor on the surface; adding an antisolvent to the precursor; and growing at least one of the quantum dots and the nanocrystals on the surface. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/538386 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0007 (20130101) H01L 51/428 (20130101) H01L 51/4213 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093967 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Hui Wang (Louisville, Kentucky); Yang Li (Louisville, Kentucky); Thad Druffel (Louisville, Kentucky) |
| ABSTRACT | Methods for wet chemical synthesis of lithium argyrodites are provided, which in some embodiments include dissolving a stoichiometric mixture of precursors in a small quantity of solvent in an argon atmosphere, drying the mixture under vacuum or an inert gas atmosphere to evaporate the solvent, and then annealing to obtain a final lithium argyrodite product. Further embodiments comprise synthesizing the precursors, excess halide doping to achieve higher ionic conductivity, and the use of carboxylic acid esters to enhance the interfacial properties of high-performance lithium batteries. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544279 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0562 (20130101) Original (OR) Class H01M 2300/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220094014 | Marr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Altect, Inc. (Austin, Texas) |
| ASSIGNEE(S) | Altect, Inc. (Austin, Texas) |
| INVENTOR(S) | Kevin Marr (Austin, Texas); Paul Lee (Frisco, Texas) |
| ABSTRACT | Apparatus and associated methods relate to a neutralization and circulation module (NCM) configured to generate a combustion suppressant stream from a flammable intake stream. In an illustrative example, the NCM includes an intake port and an output port, each in fluid communication with a chamber containing (electro)chemical energy storage units capable of emitting combustible gases. The NCM may, for example, include a reactor in fluid communication between the intake and output port. The reactor may, for example, selectively apply an oxygen-containing stream from an oxygen source to the intake stream to generate, from the stream containing combustible gases, a combustion suppressant gas stream that is discharged through the output port into the chamber such that an upper flammability limit approaches a lower flammability limit in the chamber. Various embodiments may advantageously eliminate a flammable regime in a chemical energy storage environment. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/448260 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 50/143 (20210101) H01M 50/383 (20210101) Original (OR) Class H01M 2200/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220094029 | RICHMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); United States of America as Represented by the Secretary, Department of Commerce (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brittany RICHMAN (Laurel, Maryland); Jacob TAYLOR (Cambridge, Massachusetts) |
| ABSTRACT | A circulator includes a central circuit having a first superconducting island, a second superconducting island, a third superconducting island, and a central island, each in electrical communication with each other via a plurality of Josephson junctions. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/477960 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/025 (20130101) H01L 39/223 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/383 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220094418 | POLESE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michele POLESE (Boston, Massachusetts); Francesco RESTUCCIA (Boston, Massachusetts); Tommaso MELODIA (Newton, Massachusetts) |
| ABSTRACT | A system and method for beam management in a wireless network are provided. A learning module having a trained classification module processes received I/Q input samples to determine transmitted beam information of incoming RF transmissions. The learning module includes a beam inference engine to determine waveform characteristics of incoming RF transmissions, and an angle of arrival engine operative to determine an angle of arrival of the incoming RF transmissions on an antenna array. An incoming RF transmission and angle of arrival are selected based on the determined waveforms for beam management operations. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/481378 |
| CURRENT CPC | Transmission H04B 7/086 (20130101) Original (OR) Class H04B 7/088 (20130101) H04B 7/0695 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220089817 | Ghose et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sayata Ghose (Sammamish, Washington); Marcus Anthony Belcher (Sammamish, Washington); John W. Connell (Yorktown, Virginia) |
| ABSTRACT | Compositions including a polyamide, and compaction rollers for an automated fiber placement machine incorporating the composition are provided. The polyamide may be a reaction product of at least one diamine and an aromatic dicarboxylic acid, a hydroxy benzoic acid, or their respective ester or acyl halide derivatives. The at least one diamine may include an amino terminated perfluorinated alkyl ether polymer or oligomer. The composition may have a thermal conductivity of from about 0.2 to about 50 Watts per meter Kelvin (Wm−1K−1). |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/444117 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/382 (20130101) Presses in General B30B 3/005 (20130101) B30B 9/28 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 69/32 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/013 (20180101) C08K 5/09 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091071 | Hunt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Corvid Technologies LLC (Mooresville, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean Matthew Hunt (Raleigh, North Carolina); Joseph Allen Johnson (Mooresville, North Carolina) |
| ABSTRACT | A method for evaluating a target, the target having a surface, includes pulsing a defined, energetic particle beam through the surface and into the target such that particle energy deposition from the particle beam is concentrated in a subsurface target volume within a target medium of the target. The deposited particle energy induces a thermoelastic expansion of the target medium in the target volume that generates a corresponding acoustic wave. The method further includes detecting the acoustic wave from the target medium. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370340 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/04 (20130101) G01N 29/2431 (20130101) Original (OR) Class G01N 2291/023 (20130101) G01N 2291/102 (20130101) G01N 2291/0289 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091409 | Breckenridge |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James B. Breckenridge (Tucson, Arizona) |
| ABSTRACT | An optical system comprising a segmented optical element comprising a plurality of segments disposed adjacent each other to define a pupil, wherein one or more of the plurality of segments comprises a pair of curved edges, wherein the segmented optical element is arranged such that a curved gap is defined between adjacent segments. |
| FILED | Thursday, January 09, 2020 |
| APPL NO | 17/421748 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/09 (20130101) G02B 17/06 (20130101) G02B 23/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091593 | Neilan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATIVE OF NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James H. Neilan (Seaford, Virginia); Mathew K. Mahlin (Poquoson, Virginia); John R. Cooper (Yorktown, Virginia); Laura M. White (Hampton, Virginia); Benjamin N. Kelley (Suffolk, Virginia); Matthew P. Vaughan (Hampton, Virginia); I.O.K. M. Wong (Poquoson, Virginia); John W. Mulvaney (Yorktown, Virginia); Erik E. Komendera (Christiansburg, Virginia); William D. Chapin (Radford, Virginia); Joshua N. Moser (Blacksburg, Virginia) |
| ABSTRACT | Methods and systems to control stacked hexapod platforms for use as tools, which function with both high accuracy and high precision are provided. In some embodiments, the methods and systems include a convergence of modern control theory, and machine learning. Furthermore, some embodiments provide control algorithms to carry out autonomous in-space assembly operations using assemblers. Some embodiments provide methods and systems which combine long-reach low precision manipulators and smaller, high-precision assembler with interchangeable tools. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/481805 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/36 (20130101) B64G 1/242 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/4184 (20130101) G05B 19/4188 (20130101) G05B 19/41805 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220093918 | CHOU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONDA MOTOR CO., LTD. (Tokyo, Japan); CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nam Hawn CHOU (New Berlin, Wisconsin); Kaoru OMICHI (Tochigi, Japan); Ryan MCKENNEY (Roseville, Minnesota); Qingmin XU (Dublin, Ohio); Christopher BROOKS (Dublin, Ohio); Simon C. JONES (Whittier, California); Isabelle M. DAROLLES (Azusa, California); Hongjin TAN (Pasadena, California) |
| ABSTRACT | The present disclosure relates to a method of making core-shell and yolk-shell nanoparticles, and to electrodes comprising the same. The core-shell and yolk-shell nanoparticles and electrodes comprising them are suitable for use in electrochemical cells, such as fluoride shuttle batteries. The shell may protect the metal core from oxidation, including in an electrochemical cell. In some embodiments, an electrochemically active structure includes a dimensionally changeable active material forming a particle that expands or contracts upon reaction with or release of fluoride ions. One or more particles are at least partially surrounded with a fluoride-conducting encapsulant and optionally one or more voids are formed between the active material and the encapsulant using sacrificial layers or selective etching. When the electrochemically active structures are used in secondary batteries, the presence of voids can accommodate dimensional changes of the active material. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/541838 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/62 (20130101) H01M 4/134 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/582 (20130101) H01M 4/1395 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220087285 | Guo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tai L. Guo (Bogart, Georgia); Yingjia Chen (Bogart, Georgia) |
| ABSTRACT | Therefore, disclosed herein is a composition comprising dietary early glycation products (EGPs) with less than 1 wt % advanced glycation end products (AGEs). Also disclosed is a method for treating or preventing diabetes in a subject, such as type 1 diabetes, type 2 diabetes, or gestational diabetes, that involves administering to a subject in need thereof a composition disclosed herein. |
| FILED | Wednesday, January 15, 2020 |
| APPL NO | 17/420411 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 1/20 (20130101) A23J 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088173 | Dominowski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Zoetis Services LLC (Parsippany, New Jersey); United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Joseph Dominowski (Kalamazoo, Michigan); John Morgan Hardham (Kalamazoo, Michigan); James Alan Jackson (Kalamazoo, Michigan); Cyril Gerard Gay (Bethesda, Maryland); Luis Leandro Rodriguez (Niantic, Connecticut); Peter William Krug (East Setauket, New York); Aida Elizabeth Rieder (Westbrook, Connecticut) |
| ABSTRACT | Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 μg FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided. |
| FILED | Friday, February 19, 2021 |
| APPL NO | 17/180223 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/135 (20130101) Original (OR) Class A61K 2039/55561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220090097 | Curtiss, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Arizona Board of Regents for and on Behalf of Arizona State University (Scottsdale, Arizona); The Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roy Curtiss, III (Gainesville, Florida); Shifeng Wang (Gainesville, Florida); Soo-Young Wanda (Gainesville, Florida); Wei Kong (Phoenix, Arizona) |
| ABSTRACT | The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/500940 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) A61K 39/00 (20130101) A61K 2035/11 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/36 (20130101) C12N 15/74 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220088555 | Shull et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth R. Shull (Evanston, Illinois); Yaoyao Chen (Evanston, Illinois) |
| ABSTRACT | A thermothickening fluid is provided which comprises a liquid phase; a first polymer comprising functional groups and having a room temperature solubility in the liquid phase; and a second, different polymer comprising functional groups and having a room temperature solubility in the liquid phase, wherein functional groups on the first polymer are capable of associating with functional groups on the second polymer to form complexes, and the room temperature solubility of the first polymer is greater than the room temperature solubility of the second polymer. The fluid is a colloid at room temperature, a solution at an elevated temperature, and exhibits a thermothickening/thinning transition viscosity value at a thermo-thickening/thinning transition temperature between room temperature and the elevated temperature. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/420952 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/0082 (20130101) Original (OR) Class Compositions of Macromolecular Compounds C08L 33/02 (20130101) C08L 39/08 (20130101) C08L 2201/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220089496 | Guo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ping Guo (Northfield, Illinois); Ange-Therese Akono (Evanston, Illinois); Yunzhi Xu (Evanston, Illinois) |
| ABSTRACT | Methods for the production of ceramic composites in which three-dimensional (3D) printed organic polymer fibers are embedded in an amorphous inorganic ceramic matrix are provided. The composites are made by electrospinning the organic polymer fibers and collecting them in a liquid or gel collector. Ceramic precursors added to the liquid collector after the fibers are collected, or present in the gel collector during the electrospinning, are then cured to form a solid ceramic matrix around the organic polymer fibers to produce an organic polymer fiber-reinforced ceramic. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/477892 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 16/0658 (20130101) C04B 28/008 (20130101) Original (OR) Class Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/003 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220094029 | RICHMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); United States of America as Represented by the Secretary, Department of Commerce (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brittany RICHMAN (Laurel, Maryland); Jacob TAYLOR (Cambridge, Massachusetts) |
| ABSTRACT | A circulator includes a central circuit having a first superconducting island, a second superconducting island, a third superconducting island, and a central island, each in electrical communication with each other via a plurality of Josephson junctions. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/477960 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/025 (20130101) H01L 39/223 (20130101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 1/383 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220088133 | Migrino et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); Midwestern University (Downers Grove, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond Q. Migrino (Phoenix, Arizona); Volkmar Weissig (Glendale, Arizona) |
| ABSTRACT | Disclosed herein are compositions comprising nanoliposomes useful for the treatment and prevention of stroke. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/472324 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 31/7105 (20130101) A61K 38/1709 (20130101) A61K 38/1761 (20130101) Original (OR) Class A61K 47/24 (20130101) A61K 47/28 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220088274 | Myung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The U.S. Government Represented by the Department of Veterans Affairs (Washington, District of Columbia); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Myung (Menlo Park, California); Gabriella Fernandes-Cunha (Redwood City, California); Hyun Jong Lee (Redwood City, California); Ali Djalilian (Redwood City, California) |
| ABSTRACT | Compositions and methods for repairing or regenerating damaged tissue are disclosed. In particular, the invention relates to methods of delivering secreted factors from stem cells to tissues in order to immobilize and concentrate such secreted factors at or under the surface of damaged tissue to promote tissue regeneration. |
| FILED | Friday, May 18, 2018 |
| APPL NO | 16/614205 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 35/51 (20130101) A61K 35/545 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/36 (20130101) A61L 27/52 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 2300/43 (20130101) A61L 2300/414 (20130101) A61L 2300/426 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220091071 | Hunt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Corvid Technologies LLC (Mooresville, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean Matthew Hunt (Raleigh, North Carolina); Joseph Allen Johnson (Mooresville, North Carolina) |
| ABSTRACT | A method for evaluating a target, the target having a surface, includes pulsing a defined, energetic particle beam through the surface and into the target such that particle energy deposition from the particle beam is concentrated in a subsurface target volume within a target medium of the target. The deposited particle energy induces a thermoelastic expansion of the target medium in the target volume that generates a corresponding acoustic wave. The method further includes detecting the acoustic wave from the target medium. |
| FILED | Thursday, July 08, 2021 |
| APPL NO | 17/370340 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/04 (20130101) G01N 29/2431 (20130101) Original (OR) Class G01N 2291/023 (20130101) G01N 2291/102 (20130101) G01N 2291/0289 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220091624 | LUMB |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Polaris Semiconductor LLC (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew P. LUMB (Arlington, Virginia) |
| ABSTRACT | Disclosed is a linear voltage regulator with an input terminal, an output terminal, a pass device electrically connected to the input terminal and the output terminal, and an error amplifier that controls the output voltage at the output terminal by controlling the voltage drop across the pass device. The disclosed linear voltage regulator includes a light emitting section electrically connected in series with the pass device between the input terminal and the output terminal and a photovoltaic section, electrically connected to the output terminal, that receives photons emitted by the light emitting section and outputs a current to output terminal. The disclosed linear voltage regulator is more efficient than conventional linear voltage regulators because, unlike in those convention linear voltage regulators, the voltage drop across the pass device is only a fraction of the total potential difference between the input terminal and the output terminal. |
| FILED | Thursday, March 11, 2021 |
| APPL NO | 17/198738 |
| CURRENT CPC | Systems for Regulating Electric or Magnetic Variables G05F 1/575 (20130101) Original (OR) Class Electric Heating; Electric Lighting Not Otherwise Provided for H05B 45/375 (20200101) H05B 45/395 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220092442 | Sefair Cristancho et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jorge Alberto Sefair Cristancho (Scottsdale, Arizona); Ronald Askin (Phoenix, Arizona); Girish Hanumantha (Tempe, Arizona); Berkin Arici (New York, New York); Casin Corallo (Tempe, Arizona); Troy Munson (Paradise Valley, Arizona) |
| ABSTRACT | In accordance with embodiments disclosed herein, there are provided herein systems, methods, and apparatuses for predicting and evaluating wait times and queue lengths at multi-station and multi-stage screening zones via a deterministic decision support algorithm and complementary prediction model. For example, there is disclosed in accordance with a particular embodiment, a specially configured Visual Analytics and Decision Support System platform (VADSS platform), having means by which to model, predict, and evaluate airport security wait times. Additionally described in accordance with various embodiments is a workforce allocation and configuration decision system for airport security checkpoints (e.g., number of lanes open) based on passenger volume forecasts. The accuracy of such forecasts is critical for the smooth functioning of security checkpoints where unexpected surges in passenger volumes are handled proactively. Thus, the described forecasting model combines flight schedules and other business fundamentals with historically observed throughput patterns to predict passenger volumes in a multi-terminal multi-security screening checkpoint airport. Additionally disclosed is an optimization model and a solution strategy for dynamically selecting a configuration of open screening lanes to minimize passenger queues and wait times that at the same time determine workforce allocations. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/481120 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/18 (20130101) Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Reconnaissance Office (NRO)
| US 20220089445 | WAGNER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The George Washington University (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. WAGNER (Rockville, Maryland); Nathan A. BANEK (Rockville, Maryland); Dustin T. ABELE (Arlington, Virginia); Kevin R. MCKENZIE, JR. (Arlington, Virginia) |
| ABSTRACT | High quality carbon nanochains or carbon nanotubes are produced by methods that include mixing a carbon-containing feedstock with a catalyst to form a feedstock/catalyst mixture, or coating a catalyst with a carbon-containing feedstock, and subjecting the feedstock/catalyst mixture or feedstock-coated catalyst to irradiation with a laser to convert the feedstock into carbon nanochains or carbon nanotubes in the presence of the catalyst. In some instances, the feedstock is converted to a char by pyrolysis and the char is instead subjected to laser irradiation. The carbon-containing feedstock can be a biomass or a carbonaceous material. In some instances, the catalyst is a metal salt, preferably a transition metal salt. In some instances, the catalyst is an elemental metal, an alloy, or a combination thereof. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/384364 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/121 (20130101) B01J 2219/12 (20130101) B01J 2219/0879 (20130101) B01J 2219/0892 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/18 (20170801) Original (OR) Class C01B 32/162 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220095017 | Eberle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NVIDIA Corp. (Santa Clara, California) |
| ASSIGNEE(S) | NVIDIA Corp. (Santa Clara, California) |
| INVENTOR(S) | Hans Eberle (Mountain View, California); Larry Robert Dennison (Mendon, Massachusetts) |
| ABSTRACT | A communication method between a source device and a target device utilizes speculative connection setup between the source device and the target device, target-device-side packet ordering, and fine-grained ordering to remove packet dependencies. |
| FILED | Wednesday, December 01, 2021 |
| APPL NO | 17/539947 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/20 (20130101) H04L 45/7453 (20130101) H04L 47/283 (20130101) H04L 47/624 (20130101) Pictorial Communication, e.g Television H04N 21/2387 (20130101) H04N 21/4302 (20130101) H04N 21/6583 (20130101) H04N 21/23406 (20130101) H04N 21/47217 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220089381 | Perry-Eaton |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne R. Perry-Eaton (Leesburg, Virginia) |
| ABSTRACT | An automated system for transferring articles from a container. An item transfer system includes a rotatable tray rotary assembly, a translatable and rotatable intermediate rotary assembly, and a translatable and rotatable output rotary assembly. The system is configured to transfer articles from the tray to processing equipment by an automated process including rotationally transferring the articles from the tray to the intermediate rotary assembly and rotationally transferring the articles from the intermediate rotary assembly to the output rotary assembly. The output rotary assembly can move to align with a shelf or other input of the processing equipment and a paddle assembly can slide the items from the output rotary assembly onto the shelf or other input of the processing equipment. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/478487 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 3/02 (20130101) Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 47/766 (20130101) B65G 47/902 (20130101) Original (OR) Class B65G 47/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220090505 | Farmer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GENERAL ELECTRIC COMPANY (Schenectady, New York) |
| ASSIGNEE(S) | GENERAL ELECTRIC COMPANY (SCHENECTADY, New York) |
| INVENTOR(S) | Jonathon Farmer (Newport, Kentucky); Ricardo Caraballo (Maineville, Ohio) |
| ABSTRACT | According to various embodiments, an airfoil includes an outer wall defining an airfoil body surrounding at least one cavity and a removable insert including at least one mating feature for coupling the removable insert with the airfoil body between a first location within the at least one cavity and a second location within the at least one cavity. The removable insert is free of openings and separates a first air flow path from a second air flow path through the at least one cavity. Vanes and gas turbine engines including the airfoil are also disclosed. |
| FILED | Tuesday, September 22, 2020 |
| APPL NO | 17/027884 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/188 (20130101) Original (OR) Class F01D 5/282 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, March 24, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/details-patents-20220324.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page