FedInvent™ Patent Applications

Application Details for Thursday, April 07, 2022

This page was updated on Friday, April 08, 2022 at 02:19 PM GMT

Department of Health and Human Services (HHS)

20220104468 — MODULATION OF LC3-ASSOCIATED ENDOCYTOSIS PATHWAY AND GENETICALLY MODIFIED NON-HUMAN ANIMALS AS A MODEL OF NEUROINFLAMMATION AND NEURODEGENERATION

US 20220104468	Heckmann et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	St. Jude Children's Research Hospital (Memphis, Tennessee)
ASSIGNEE(S)	St. Jude Children's Research Hospital (Memphis, Tennessee)
INVENTOR(S)	Bradlee L. Heckmann (Memphis, Tennessee); Douglas R. Green (Memphis, Tennessee)
ABSTRACT	Compositions and methods are provided for modifying and treating neuroinflammatory and neurodegenerative diseases. The methods and compositions can be used to ameliorate the effects of a deficiency in the LC3-associated endocytosis (LANDO) pathway for clearing β-amyloid. Thus, methods are further provided for modulating β-amyloid clearance using an effective amount of a pharmaceutical composition that targets the LANDO pathway. Accordingly, pharmaceutical compositions that target the LANDO pathway are provided herein. The methods and compositions described herein can be used to treat neuroinflammatory and neurodegenerative diseases, such as Alzheimer's disease.
FILED	Wednesday, January 22, 2020
APPL NO	17/425106
CURRENT CPC	Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0276 (20130101) Original (OR) Class A01K 2217/075 (20130101) A01K 2217/206 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5023 (20130101) G01N 33/5088 (20130101) G01N 2800/2821 (20130101)
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20220104482 — Compositions, Methods and Kits for Stabilizing Cells and Biological Samples

US 20220104482	Toner et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts); Sapere Bio, Inc. (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S)	Mehmet Toner (Charlestown, Massachusetts); Rebecca Sandlin (Melrose, Massachusetts); Anne Knecht (Chapel Hill, North Carolina); Ho Ki Wong (Newton, Massachusetts); Shannon N. Tessier (Framingham, Massachusetts); Shannon Stott (Stoneham, Massachusetts)
ABSTRACT	Compositions, methods and kits are described for stabilizing cells and biological samples, allowing for storage and transportation of stabilized cells and biological samples. Cells can be stabilized in whole blood or fractionated blood. Isolated cells can also be stabilized.
FILED	Friday, February 07, 2020
APPL NO	17/428453
CURRENT CPC	Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0226 (20130101) Original (OR) Class A01N 1/0252 (20130101)
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20220104759 — Reversal of General Anesthesia by Administration of Methylphenidate, Amphetamine, Modafinil, Amantadine, and/or Caffeine

US 20220104759	Brown et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) NIH Office of the Director (NIHOD)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S)	Emery N. Brown (Brookline, Massachusetts); Ken Solt (Lexington, Massachusetts); Joseph F. Cotten (Northborough, Massachusetts); Jessica J. Chemali (Cambridge, Massachusetts); Frederick M. Debros (Boston, Massachusetts)
ABSTRACT	The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general anesthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.
FILED	Monday, August 16, 2021
APPL NO	17/403800
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/316 (20210101) A61B 5/369 (20210101) A61B 5/4821 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/13 (20130101) A61K 31/137 (20130101) A61K 31/165 (20130101) A61K 31/522 (20130101) A61K 31/4458 (20130101) A61K 45/06 (20130101)
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20220104783 — SYSTEM AND METHOD FOR LOW-DOSE MULTI-SPECTRAL X-RAY TOMOGRAPHY

US 20220104783	Pan et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S)	Xiaochuan Pan (Chicago, Illinois); Buxin Chen (Chicago, Illinois); Zheng Zhang (Chicago, Illinois); Emil Sidky (Chicago, Illinois); Dan Xia (Chicago, Illinois)
ABSTRACT	A multi-spectral tomography imaging system includes one or more source devices configured to direct beams of radiation in multiple spectra to a region of interest (ROI), and one or more detectors configured to receive the beams of radiation. The system includes a processor configured to cause movement in at least one of the components such that a first beam of radiation with a first spectrum is directed to the ROI for less than 360 degrees of movement of the ROI. The processor is also configured to process data detected by the one or more detectors, where the data results at least in part from the first beam of radiation with the first spectrum that is directed to the ROI for less than the 360 degrees of movement of the ROI. The processor is further configured to generate an image of the ROI based on the processed data.
FILED	Tuesday, December 14, 2021
APPL NO	17/550711
CURRENT CPC	Diagnosis; Surgery; Identification A61B 6/08 (20130101) A61B 6/032 (20130101) A61B 6/469 (20130101) Original (OR) Class A61B 6/482 (20130101) A61B 6/4064 (20130101) A61B 6/5205 (20130101)
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20220105011 — ANTIMICROBIAL AZO COMPOUNDS AND USES THEREOF

US 20220105011	NAIR et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	The Regents Of The University Of Colorado, A Body Corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S)	Devatha P. NAIR (Denver, Colorado); Dylan MORI (Denver, Colorado); Michael J. SCHURR (Denver, Colorado)
ABSTRACT	Antimicrobial azo compounds include azobenzene monomers having a phenyl ring comprising a hydroxyl substituent group. The azobenzene monomers can be reacted with a polymeric material to form an antimicrobial coating that prevents growth of persistent biofilms. In some implementations, the azobenzene monomers can be used to coat the surface of a dental resin-based composite to prevent the formation secondary caries. In some implementations, the azobenzene coating can be used to disperse microbial biofilms through a photofluidization process (rapid photoisomerization) in addition to biochemically preventing formation of the microbial biofilm.
FILED	Friday, February 21, 2020
APPL NO	17/432542
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 6/69 (20200101) Original (OR) Class Acyclic or Carbocyclic Compounds C07C 245/02 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 265/04 (20130101)
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20220105039 — Use of Nanoparticles to Stabilize and Preserve the Bioactivity of Proteins and Peptides

US 20220105039	Cui et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S)	Xinyan Cui (Wexford, Pennsylvania); Kevin M. Woeppel (Pittsburgh, Pennsylvania)
ABSTRACT	Provided herein are methods of making and using storage-stable protein-coated articles that retain activity after drying. Also provided herein are kits comprising storage-stable protein-coated articles that retain activity after drying.
FILED	Thursday, April 23, 2020
APPL NO	17/605718
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/1486 (20130101) A61B 2562/125 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/1611 (20130101) A61K 9/1658 (20130101) Original (OR) Class Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0565 (20130101)
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20220105042 — POLYMERIC IMPLANTS WITH HIGH DRUG LOADING AND LONG-ACTING DRUG RELEASE AND METHODS OF MAKING THE SAME

US 20220105042	Kovarova et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S)	Martina Kovarova (Chapel Hill, None); Soumya Rahima Benhabbour (Chapel Hill, None); J. Victor Garcia-Martinez (Durham, None); Panita Maturavongsadit (Chapel Hill, None)
ABSTRACT	Disclosed herein are polymeric implants and controlled release drug delivery systems to provide high drug loading and long-acting drug release. Provided herein are methods for making the same. Methods of administering pharmacologically active agents via the disclosed polymeric implants and controlled release drug delivery systems are also provided.
FILED	Friday, January 31, 2020
APPL NO	17/427190
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 9/204 (20130101) Original (OR) Class A61K 9/2095 (20130101) A61K 45/06 (20130101)
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20220105066 — Antidotes to Cyanide Poisoning

US 20220105066	Peterson et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts); The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S)	Randall Peterson (Stoneham, Massachusetts); Robert Gerszten (Brookline, Massachusetts); Anjali Nath (Boston, Massachusetts); Calum MacRae (Wellesley Hills, Massachusetts); Gerry Boss (La Jolla, California); Matt Brenner (Irvine, California); Sari Brenner Mahon (Irvine, California)
ABSTRACT	The present application provides, inter alia, a compound of Formula (I): or a pharmaceutically acceptable salt thereof, and methods of use of the compound of Formula (I) for treatment and prevention of cyanide poisoning.
FILED	Thursday, October 14, 2021
APPL NO	17/450890
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/282 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/02 (20180101)
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20220105069 — METHODS FOR TREATING BRAIN METASTASIS

US 20220105069	Massague et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S)	MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
INVENTOR(S)	Joan Massague (New York, New York); Adrienne Boire (New York, New York); Qing Chen (Palisades Park, New Jersey)
ABSTRACT	The present invention relates to methods for treating brain metastasis by inhibiting gap junction functionality. It is based, at least in part, on the discovery that cancer cells expressing Protocadherin 7 and Connexin 43 form gap junctions with astrocytes that promote the growth of brain metastases, and that inhibition of Protocadherin 7 and/or Connexin 43 expression in cancer cells reduce progression of brain metastases. It is further based on the discovery that treatment with gap junction inhibitors tonabersat and meclofenamate inhibited progression of brain metastatic lesions and enhanced the anti-cancer activity of the conventional chemotherapeutic agent, carboplatin.
FILED	Friday, June 11, 2021
APPL NO	17/345572
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/196 (20130101) A61K 31/282 (20130101) A61K 31/352 (20130101) Original (OR) Class A61K 31/555 (20130101) A61K 31/7105 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 2333/705 (20130101)
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20220105074 — ORAL ADMINISTRATION OF MELANIN FOR PROTECTION AGAINST RADIATION

US 20220105074	DADACHOVA et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York)
ASSIGNEE(S)
INVENTOR(S)	Ekaterina DADACHOVA (Mahopac, New York); Arturo CASADEVALL (Pelham, New York)
ABSTRACT	Methods and compositions are provided for alleviating and/or preventing one or more side effects associated with exposure to radiation in a subject exposed to radiation or at risk for exposure to radiation comprising oral administration to the subject of an amount of an edible source of melanin effective to alleviate a side effect associated with radiation.
FILED	Friday, July 09, 2021
APPL NO	17/372080
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0095 (20130101) A61K 31/05 (20130101) A61K 31/136 (20130101) A61K 31/198 (20130101) A61K 31/404 (20130101) Original (OR) Class A61K 36/06 (20130101) A61K 36/07 (20130101)
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20220105078 — USES OF 4'-DESFERRITHIOCIN ANALOGS

US 20220105078	Bergeron, JR.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	Raymond J. Bergeron, JR. (Gainesville, Florida)
ABSTRACT	Macular degeneration, closed head injury, stroke, irritable bowel disease, and reperfusion injury are all associated with biological injury due to reactive oxygen species, probably due to focal iron overload in many instances. The present invention provides methods and pharmaceutical compositions for treating these diseases and conditions using desferrithiocin analogs of Formula (I). In certain embodiments, the analogs include a poly ether moiety at the 4′-position of the phenyl ring of the compound.
FILED	Friday, May 14, 2021
APPL NO	17/321210
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/426 (20130101) Original (OR) Class Heterocyclic Compounds C07D 277/10 (20130101)
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20220105083 — USES OF COMPOUNDS HAVING ANTI-HSV-1 ACTIVITY

US 20220105083	Hurley et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona); Università degli Studi di Padova (Padova, Italy)
ASSIGNEE(S)
INVENTOR(S)	Laurence Hurley (Tucson, Arizona); Sara Richter (Padova, Italy); Paola Soldà (Padova, Italy)
ABSTRACT	This invention provides methods of treating, suppressing, inhibiting, reducing an incidence, reducing the pathogenesis of, ameliorating the symptoms of, or ameliorating the secondary symptoms of a primary or recurring Herpes Simplex Virus (HSV) infection, or prolonging the latency to a relapse of an HSV infection, and disorders and symptoms associated with same in a subject comprising the step of contacting the subject with a composition comprising a quindoline (or similar) structure having significant anti-HSV activity.
FILED	Wednesday, January 29, 2020
APPL NO	17/426935
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101)
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20220105099 — METHOD FOR THE DETECTION OF DRUG-INDUCED ORGAN OR TISSUE INJURY IN IMPDH INHIBITOR TREATED PATIENTS

US 20220105099	Sasaki et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	University of Cincinnati (Cincinnati, Ohio); Children's Hospital Los Angeles (Los Angeles, California)
ASSIGNEE(S)
INVENTOR(S)	Atsuo Sasaki (Cincinnati, Ohio); Mikako Warren (Pasadena, California)
ABSTRACT	The present disclosure concerns methods of detecting injury to a tissue and/or organ in a subject. In some aspects, the subject is the recipient of a transplant, such as a liver transplant. In some aspects, the subject is undergoing treatment with an immunosuppressant. In some aspects, the present disclosure concerns the identification of aberrant mitochondria in the subject to identify injury to the tissue and/or organ of the subject. Detecting aberrant mitochondria allows for remedial and/or corrective action to prevent or avoid significant injury.
FILED	Wednesday, October 06, 2021
APPL NO	17/494968
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/5377 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101)
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20220105105 — NT5C2 INHIBITORS FOR THE TREATMENT OF CHEMOTHERAPY-RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA

US 20220105105	Dieck et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S)
INVENTOR(S)	Chelsea Dieck (New York, New York); Adolfo Ferrando (New York, New York); Arie Zask (New York, New York); Brent Stockwell (New York, New York)
ABSTRACT	Various embodiments relate to compounds, having structures according to Structure A or Structure B, as specified herein. The compounds according to various embodiments may inhibit NT5C2 nucleotidase. The compounds according to various embodiments may synergistically decrease cell viability of NT5C2 R367Q mutant lymphoblasts when used in combination with 6-mercaptopurine (6-MP) to treat a cancer. The cancer may be, but is not limited to, acute lymphoblastic leukemia. Various embodiments relate to a compositions that may include one or more compounds according to any embodiment described herein or a pharmaceutically acceptable salt or derivative thereof and a pharmaceutically acceptable carrier. Various embodiments relate to methods of treating cancer. The method may comprise administering a therapeutically effective amount of one or more compounds according to any embodiment described herein or a pharmaceutically acceptable salt or derivative thereof.
FILED	Tuesday, December 14, 2021
APPL NO	17/644187
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) A61K 31/428 (20130101) A61K 31/4025 (20130101) A61K 31/4184 (20130101) A61K 31/4704 (20130101) A61K 31/5415 (20130101) Original (OR) Class A61K 45/06 (20130101) Heterocyclic Compounds C07D 217/26 (20130101) C07D 333/66 (20130101) C07D 401/06 (20130101) C07D 401/14 (20130101) C07D 409/12 (20130101) C07D 417/12 (20130101) C07D 471/04 (20130101) C07D 495/04 (20130101)
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20220105124 — METHODS FOR TARGETED TREATMENT AND PREDICTION OF PATIENT SURVIVAL IN CANCER

US 20220105124	Tran et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S)	David Tran (Gainesville, Florida); Son Bang Le (Gainesville, Florida)
ABSTRACT	Provided herein are methods of assessing, detecting, monitoring the presence, or monitoring progression of cancer in a subject, or assessing or predicting prognosis or survival of a subject having cancer. Also provided are methods of treating cancer based on an increase in the expression of one or more top master regulators of a cancer.
FILED	Thursday, February 06, 2020
APPL NO	17/428749
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/19 (20130101) A61K 31/155 (20130101) A61K 31/167 (20130101) A61K 31/409 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/593 (20130101) A61K 31/4045 (20130101) A61K 31/4406 (20130101) A61K 31/4545 (20130101) A61K 31/4709 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 35/15 (20130101) A61K 38/15 (20130101) A61K 38/179 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101)
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20220105133 — TUMOR INFILTRATING LYMPHOCYTES AND METHODS OF THERAPY

US 20220105133	Moriarity et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	Regents of the University of Minnesota (Minneapolis, Minnesota); Intima Bioscience, Inc. (New York, New York); The U.S.A., as Represented by the Secretary, Department of Health and Human Service (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S)	Branden Moriarity (Shoreview, Minnesota); Beau Webber (Coon Rapids, Minnesota); Modassir Choudhry (New York, New York); Steven A. Rosenberg (Potomac, Maryland); Douglas C. Palmer (North Bethesda, Maryland); Nicholas P. Restifo (Chevy Chase, Maryland)
ABSTRACT	Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
FILED	Wednesday, September 22, 2021
APPL NO	17/481404
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0053 (20130101) A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) A61P 35/00 (20180101) Peptides C07K 14/4703 (20130101) C07K 14/7051 (20130101) C07K 14/7158 (20130101) C07K 14/70503 (20130101) C07K 14/70521 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 15/79 (20130101) C12N 15/113 (20130101) C12N 15/902 (20130101) C12N 2310/20 (20170501)
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20220105137 — BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF

US 20220105137	Payne et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S)	Thomas Payne (Pittsburgh, Pennsylvania); Ronald Jankowski (Pittsburgh, Pennsylvania); Ryan Pruchnic (Pittsburgh, Pennsylvania)
ABSTRACT	The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
FILED	Tuesday, May 18, 2021
APPL NO	17/323114
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 35/34 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0654 (20130101) C12N 5/0658 (20130101) C12N 5/0659 (20130101)
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20220105148 — COMPOSITIONS AND METHODS FOR PREVENTING AND REDUCING INFLAMMATION AND TREATING DISORDERS ASSOCIATED WITH INFLAMMATION

US 20220105148	Hawiger et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S)	Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S)	Jack J. Hawiger (Nashville, Tennessee); Ruth Ann Veach (Brentwood, Tennessee); Yan Liu (Nashville, Tennessee); Huan Qiao (Nashville, Tennessee); Lukasz S. Wylezinski (Nashville, Tennessee)
ABSTRACT	The present invention relates to compositions and methods for preventing and reducing inflammation and preventing and treating diseases and disorders associated with inflammation. It has been shown that CRADD plays a pivotal role in maintaining the integrity of endothelial monolayers. The recombinant cell-penetrating CRADD protein (CP-CRADD)-based compositions and methods described herein provide for the development of a novel treatment for inflammatory vascular disorders including cardiovascular, cerebrovascular, respiratory, gastrointestinal, and renal systems.
FILED	Monday, June 07, 2021
APPL NO	17/341379
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/10 (20130101) Original (OR) Class A61K 38/1825 (20130101) Peptides C07K 7/00 (20130101) C07K 2319/00 (20130101)
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20220105150 — AMPHIPATHIC ALPHA-HELICAL ANTIMICROBIAL PEPTIDES TREAT INFECTIONS BY GRAM-NEGATIVE PATHOGENS

US 20220105150	HODGES et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S)	Robert S. HODGES (Aurora, Colorado); Colin T. MANT (Denver, Colorado); Ziqing JIANG (Westminster, Colorado); Lajos GERA (Centennial, Colorado)
ABSTRACT	Antimicrobial agents, including antimicrobial peptides (AMPs), and uses thereof. Compositions and methods of using AMPs that demonstrate activity and improved therapeutic indices against microbial pathogens. The AMPs demonstrate the ability to not only maintain or improve antimicrobial activity against bacterial pathogens including Gram-negative microorganisms Acinetobacter-baumannii and Pseudomonas aeruginosa, but also significantly decrease hemolytic activity against human red blood cells. Specificity determinants within the AMPs change selectivity from broad spectrum antimicrobial activity to Gram-negative selectivity.
FILED	Wednesday, January 15, 2020
APPL NO	17/423611
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/16 (20130101) Original (OR) Class A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101)
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20220105151 — ASARM TREATMENT FOR KIDNEY AND MINERALIZATION DISORDERS AND HYPERPHOSPHATEMIA

US 20220105151	Rowe
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The University of Kansas (Lawrence, Kansas)
ASSIGNEE(S)
INVENTOR(S)	Peter S. N. Rowe (Overland Park, Kansas)
ABSTRACT	A method of treating or inhibiting a kidney disorder can include administering a therapeutically effective amount of the ASARM peptide to provide a treatment for the kidney disorder (treat disease) and/or inhibit development of the kidney disorder (prophylactic). The kidney disorder can be selected from the group consisting of chronic kidney disease mineral bone disorder (CKD-MBD), calciphylaxis, nephrogenic systemic fibrosis (NSF), end stage renal disease, and combinations thereof. The therapy can include inhibiting vascular calcification (VC), hard tissue calcification, soft tissue calcification, mineralization, or combinations thereof in the subject with the ASARM peptide. A method of inhibiting mineralization can include administering a therapeutically effective amount of the ASARM peptide to provide a treatment for inhibit mineralization in the subject. A method of treating hyperphosphatemia can include administering a therapeutically effective amount of the ASARM peptide to a subject to provide a treatment for hyperphosphatemia.
FILED	Wednesday, October 06, 2021
APPL NO	17/495556
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101)
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20220105152 — Composition for and Method of Treating Hepatic Tissue Injury

US 20220105152	ZENG et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	OHIO STATE INNOVATION FOUNDATION (COLUMBUS, Ohio)
ASSIGNEE(S)	OHIO STATE INNOVATION FOUNDATION (COLUMBUS, Ohio); DAPING HOSPITAL, ARMY MEDICAL UNIVERSITY (Chongqing, China PRC)
INVENTOR(S)	CHUNYU ZENG (CHONGQING, China PRC); Yu HAN (CHONGQING, China PRC); Jianjie MA (Powell, Ohio); Tao TAN (Columbus, Ohio)
ABSTRACT	Compositions for and methods of treating liver injury are provided. Said compositions comprise MG53 or express MG53. Said compositions can be used for treating chronic or acute injured liver tissue and can be administered systemically, locally, or both.
FILED	Monday, December 13, 2021
APPL NO	17/549105
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/1709 (20130101) Original (OR) Class A61K 47/46 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101)
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20220105173 — VACCINATION USING HERPESVIRUS GENOMES IN NUCLEIC ACID FORM

US 20220105173	Hartigan-O'Connor et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Dennis Hartigan-O'Connor (Davis, California); Peter Barry (Davis, California); Jesse Deere (Davis, California); Joseph Dutra (Davis, California)
ABSTRACT	The present invention provides compositions and methods for inducing immune responses in subjects using HV-based vectors that can be grown in single celled organisms and administered in their nucleic acid form.
FILED	Tuesday, October 26, 2021
APPL NO	17/510969
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/245 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/16034 (20130101) C12N 2710/16043 (20130101) C12N 2710/16045 (20130101)
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20220105179 — GLYCOENGINEERING IMMUNOGLOBULIN E

US 20220105179	Anthony et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S)	Robert M. Anthony (Cambridge, Massachusetts); Kai-Ting Chuang (Arlington, Massachusetts); Maya Kitaoka (Arlington, Massachusetts)
ABSTRACT	This disclosure relates to glycoengineering, and methods of utilizing glycoengineering for treating various diseases or disorders (e.g., IgE-mediated disorders). The methods include administering to the subject an effective amount of a composition comprising a fusion protein described herein. In some embodiments, the IgE-mediated disorder is an allergic disorder. In some embodiments, the allergic disorder is an anaphylactic allergy.
FILED	Friday, February 14, 2020
APPL NO	17/430949
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) A61K 39/395 (20130101) Original (OR) Class A61K 47/6815 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/08 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2402 (20130101) C12N 15/62 (20130101) C12N 15/85 (20130101) C12N 2800/107 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Enzymes C12Y 302/01018 (20130101)
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20220105186 — Compositions Containing Nucleosides and Manganese and Their Uses

US 20220105186	Daly et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Energy (DOE) Office of Science (DOE-SC) Environmental Remediation Sciences Program (ERSP) Department of Health and Human Services (HHS)
APPLICANT(S)	The Henry M. Jackson Foundation for the Advancement of Military Medice, Inc. (Besthesda, Maryland); The Government of the USA as Represented by the Secretary Department of Health and Human Services (Rockville, Maryland)
ASSIGNEE(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Government of the USA as Represented by the Secretary Department of Health and Human Services (Rockville, Maryland)
INVENTOR(S)	Michael J. Daly (Washington, District of Columbia); Elena K. Gaidamakova (Gaithersburg, Maryland); Vera Y. Matrosova (Rockville, Maryland); Rodney L. Levine (Rockville, Maryland); Nancy B. Wehr (Bethesda, Maryland)
ABSTRACT	This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.
FILED	Tuesday, November 02, 2021
APPL NO	17/517148
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 8/24 (20130101) A61K 8/44 (20130101) A61K 8/99 (20130101) A61K 8/606 (20130101) A61K 31/7072 (20130101) A61K 31/7076 (20130101) A61K 33/32 (20130101) A61K 35/74 (20130101) A61K 45/06 (20130101) Original (OR) Class Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101)
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20220105243 — ENGINEERING MECHANICALLY FUNCTIONAL HUMAN CARTILAGE AND METHOD OF MAKING SAME

US 20220105243	Bhumiratana et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	Sarindr Bhumiratana (Oceanside, New York); Gordana Vunjak-Novakovic (New York, New York)
ABSTRACT	Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.
FILED	Thursday, October 21, 2021
APPL NO	17/506831
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/3094 (20130101) A61F 2/30756 (20130101) A61F 2002/30762 (20130101) A61F 2002/30766 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/46 (20130101) A61L 27/50 (20130101) A61L 27/56 (20130101) A61L 27/425 (20130101) A61L 27/3608 (20130101) A61L 27/3612 (20130101) Original (OR) Class A61L 27/3834 (20130101) A61L 2400/06 (20130101) A61L 2430/06 (20130101) A61L 2430/10 (20130101)
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20220105244 — METHODS AND COMPOSITIONS FOR PROTECTION OF BIOPROSTHETIC HEART VALVE TISSUE FROM GLYCATION AND ASSOCIATED PROTEIN INCORPORATION

US 20220105244	Ferrari et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)
INVENTOR(S)	Giovanni Ferrari (Hastings on Hudson, New York); Antonio Frasca (Bronx, New York)
ABSTRACT	Compositions and methods for protecting BHV from SVD mechanisms, including non-calcific SVD mechanisms, are provided.
FILED	Tuesday, October 12, 2021
APPL NO	17/499636
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/4015 (20130101) A61K 31/4164 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3687 (20130101) Original (OR) Class A61L 2300/40 (20130101) A61L 2300/204 (20130101) A61L 2430/20 (20130101)
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20220105270 — Model-Based Personalization Scheme of an Artificial Pancreas for Type I Diabetes Applications

US 20220105270	Doyle, III et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Francis J. Doyle, III (Santa Barbara, California); Eyal Dassau (Santa Barbara, California); Dale E. Seborg (Santa Barbara, California); Joon Bok Lee (Santa Barbara, California)
ABSTRACT	A model-based control scheme consisting of either a proportional-integral-derivative (IMC-PID) controller or a model predictive controller (MPC), with an insulin feedback (IFB) scheme personalized based on a priori subject characteristics and comprising a lower order control-relevant model to obtain PID or MPC controller for artificial pancreas (AP) applications.
FILED	Tuesday, December 14, 2021
APPL NO	17/549935
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/022 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/1723 (20130101) Original (OR) Class A61M 2005/1726 (20130101) A61M 2205/52 (20130101)
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20220105362 — RE-ACTIVATABLE RADIATION SOURCE FOR BRACHYTHERAPY

US 20220105362	Flynn et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Biomedical Imaging and Bioengineering (NIBIB) Small Business Administration (SBA) Small Business Technology Transfer (STTR)
APPLICANT(S)	UNIVERSITY OF IOWA RESEARCH FOUNDATION (IOWA CITY, Iowa)
ASSIGNEE(S)
INVENTOR(S)	Ryan T. Flynn (Iowa City, Iowa); QUENTIN E. ADAMS (Iowa City, Iowa); KAROLYN M. HOPFENSPERGER (lowa City, Iowa)
ABSTRACT	A method can comprise irradiating an active element having an initial total activity between zero and thirty curies of ytterbium-169 and a volume between about two cubic millimeters and about four cubic millimeters. Irradiation can be ceased before the active element surpasses a total activity of thirty curies and an activity concentration of ten curies per cubic millimeter.
FILED	Tuesday, February 11, 2020
APPL NO	17/428035
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1007 (20130101) Original (OR) Class A61N 2005/1008 (20130101) A61N 2005/1022 (20130101)
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20220106250 — DERIVATIVES OF SULINDAC CAN PROTECT NORMAL CELLS AGAINST OXIDATIVE DAMAGE

US 20220106250	Piazza et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	UNIVERSITY OF SOUTH ALABAMA (Mobile, Alabama)
ASSIGNEE(S)	UNIVERSITY OF SOUTH ALABAMA (Mobile, Alabama)
INVENTOR(S)	Gary Piazza (Daphne, Alabama); Xi Chen (Hoover, Alabama); Herbert Weissbach (Boynton Beach, Florida); Shailaja Kesraju Allani (Boynton Beach, Florida)
ABSTRACT	The disclosure provides chemical compounds possessing therapeutic and/or protective properties against oxidative damage. Methods of making such therapeutic and/or protective compounds and associated compositions are also provided, as are methods for their use, which include protecting cells from oxidative damage and/or inhibiting production of ROS in a cell or subject, as well as preventing or reducing the extent of tissue damage caused by an ischemic event in a subject at elevated risk of such an event.
FILED	Monday, November 15, 2021
APPL NO	17/526742
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Acyclic or Carbocyclic Compounds C07C 59/72 (20130101) Original (OR) Class
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20220106265 — COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

US 20220106265	Thiele et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	DUKE UNIVERSITY (Durham, North Carolina)
ASSIGNEE(S)	DUKE UNIVERSITY (Durham, North Carolina)
INVENTOR(S)	Dennis J. Thiele (Chapel Hill, North Carolina); Bushu Dong (Durham, North Carolina); Alexander M. Jaeger (Cambridge, Massachusetts); Philip F. Hughes (Chapel Hill, North Carolina); Timothy Haystead (Durham, North Carolina); Jiyong Hong (Durham, North Carolina)
ABSTRACT	This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.
FILED	Wednesday, December 11, 2019
APPL NO	17/312858
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Acyclic or Carbocyclic Compounds C07C 225/20 (20130101) C07C 275/30 (20130101) Original (OR) Class C07C 275/34 (20130101) C07C 279/18 (20130101) C07C 281/06 (20130101) C07C 311/46 (20130101) C07C 317/36 (20130101) Heterocyclic Compounds C07D 213/40 (20130101) C07D 213/75 (20130101) C07D 223/04 (20130101) C07D 229/02 (20130101) C07D 231/56 (20130101) C07D 233/64 (20130101) C07D 241/24 (20130101) C07D 249/14 (20130101) C07D 271/12 (20130101) C07D 285/10 (20130101) C07D 317/66 (20130101) C07D 333/20 (20130101) C07D 333/36 (20130101) C07D 333/72 (20130101) C07D 405/04 (20130101) C07D 405/12 (20130101) C07D 417/12 (20130101)
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20220106278 — REAGENTS AND METHODS FOR TETRAZINE SYNTHESIS

US 20220106278	Fox et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Institute of General Medical Sciences (NIGMS) NIH Office of the Director (NIHOD) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	University of Delaware (Newark, Delaware)
ASSIGNEE(S)	University of Delaware (Newark, Delaware)
INVENTOR(S)	Joseph M. Fox (Landenberg, Pennsylvania); William Lambert (Gurnee, Illinois); Yinzhi Fang (Newark, Delaware); Christopher William am Ende (Mystic, Connecticut); Subham Mahapatra (Groton, Connecticut); Yixin XIE (Newark, Delaware); Chuanqi Wang (Newark, Delaware)
ABSTRACT	Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.
FILED	Friday, October 01, 2021
APPL NO	17/492016
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/0298 (20130101) B01J 31/2265 (20130101) B01J 31/2409 (20130101) B01J 2531/824 (20130101) Heterocyclic Compounds C07D 257/08 (20130101) Original (OR) Class C07D 401/04 (20130101) C07D 401/14 (20130101) C07D 403/08 (20130101) C07D 405/04 (20130101) C07D 409/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/022 (20130101) Steroids C07J 43/003 (20130101)
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20220106302 — ITRACONAZOLE ANALOGS AND USE THEREOF

US 20220106302	Liu et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Johns Hopkins University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S)	Jun Liu (Baltimore, Maryland); Yingjun Li (Baltimore, Maryland); Kalyan Kumar Pasunooti (Baltimore, Maryland); Wukun Liu (Baltimore, Maryland); Wei Shi (Baltimore, Maryland); Ruojing Li (Baltimore, Maryland); Sarah Head (Baltimore, Maryland)
ABSTRACT	Itraconazole, a widely used antifungal drug, has been found to possess potent anti-angiogenic and anti-hedgehog activities, exhibiting promising antitumor activity in several human clinical studies. The wider use of itraconazole in the treatment of cancer, however, has been limited by its potent inhibition of the drug metabolic enzyme CYP3A4 which causes drug-drug interactions. In an effort to eliminate the CYP3A4 inhibition of itraconazole while retaining its anti-angiogenic activity, we synthesized a series of itraconazole derivatives. The newly synthesized analogs of itraconazole were evaluated for their cytotoxicity against human umbilical vein endothelial cells (HUVEC) and their inhibitory activity against CYP3A4 enzyme.
FILED	Thursday, October 03, 2019
APPL NO	17/282378
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Heterocyclic Compounds C07D 405/14 (20130101) Original (OR) Class
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20220106348 — N-ACETYLATED SIALIC ACIDS AND RELATED SIALOSIDES

US 20220106348	CHEN et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Child Health and Human Development (NICHD) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S)	Xi CHEN (Davis, California); An XIAO (Davis, California); Anoopjit KOONER (Davis, California); Abhishek SANTRA (Davis, California); Ajit VARKI (San Diego, California); Hai YU (Davis, California); Lee-Ping WANG (Davis, California); Wanqing LI (Davis, California)
ABSTRACT	The present invention provides N-acetyl derivatives of sialic acids, including N-acetyl derivatives of Neu5Ac and Neu5Gc. Methods for preparing related precursors and a variety of sialosides are also disclosed.
FILED	Thursday, September 30, 2021
APPL NO	17/491518
CURRENT CPC	Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/04 (20130101) Original (OR) Class C07H 15/12 (20130101) C07H 15/14 (20130101) C07H 15/203 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/28 (20130101) C12P 19/44 (20130101) C12P 19/64 (20130101)
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20220106360 — NEUROPROTECTIVE PEPTIDES AND METHODS OF THEIR USE

US 20220106360	Aizenman et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S)	University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)	University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
INVENTOR(S)	Elias Aizenman (Pittsburgh, Pennsylvania); Jason Arnold Justice (Plymouth, Minnesota); Anthony John Schulien (Pittsburgh, Pennsylvania)
ABSTRACT	Neuroprotective peptides derived from the voltage-gated potassium channel Kv2.2 are described. The peptides promote dispersal of the cognate channel Kv2.1 in neurons, thereby blocking pro-apoptotic potassium efflux, and preserving cell viability after apoptotic injury. Methods of preventing and treating neuronal damage, such as neuronal damage following ischemic stroke, by administering the neuroprotective peptides are described. Fusion of the neuroprotective peptides to a cell-penetrating peptide to promote cellular uptake is also described.
FILED	Tuesday, October 05, 2021
APPL NO	17/494605
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 2319/10 (20130101)
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20220106370 — VARIANT SURVIVIN VACCINE FOR TREATMENT OF CANCER

US 20220106370	LOCKE et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida); THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (PHILADELPHIA, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S)	FREDERICK L. LOCKE (LUTZ, Florida); DARIO ALTIERI (PHILADELPHIA, Pennsylvania); SCOTT ANTONIA (LAND O'LAKES, Florida); CLAUDIO ANASETTI (SAINT PETERSBURG, Florida); DMITRY GABRILOVICH (VILLANOVA, Pennsylvania)
ABSTRACT	The invention concerns a variant (double mutant form) of the survivin polypeptide; nucleic acid molecules encoding the survivin variant; antigen presenting cells (APCs) such as dendritic cells, or APC precursors, comprising the variant survivin polypeptide or encoding nucleic acid sequence; and methods for treating a malignancy, such as myeloma, or for inducing an immune response, utilizing a variant survivin polypeptide, nucleic acid molecule, or APC.
FILED	Monday, October 18, 2021
APPL NO	17/451176
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/00115 (20180801) A61K 2039/5154 (20130101) A61K 2039/5156 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4702 (20130101) C07K 14/4703 (20130101) Original (OR) Class
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20220106372 — METHODS, COMPOSITIONS AND USES THEREOF FOR REVERSING SACROPENIA

US 20220106372	KARSENTY et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (, None)
INVENTOR(S)	GERARD KARSENTY (New York, New York); JULIAN BERGER (New York, New York)
ABSTRACT	Exemplary methods, compositions and uses thereof can be provided for preventing, reducing and/or treating loss of muscle function. In particular, e.g., it is possible to administer to a subject a pharmaceutical composition comprising a therapeutically effective amount of an agent that enhances Interleukin-6 (IL) release during exercise, and optionally a pharmaceutically acceptable carrier or excipient.
FILED	Monday, October 18, 2021
APPL NO	17/504158
CURRENT CPC	Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/06 (20180101) Peptides C07K 14/5412 (20130101) Original (OR) Class C07K 2319/00 (20130101)
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20220106376 — METHODS, COMPOSITIONS AND USES THEREOF FOR REVERSING SACROPENIA

US 20220106376	KARSENTY et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)	The Trustees of Columbia University in the City of New York (New York, New York)
INVENTOR(S)	GERARD KARSENTY (New York, New York); JULIAN BERGER (New York, New York)
ABSTRACT	Exemplary methods, compositions and uses thereof can be provided for preventing, reducing and/or treating loss of muscle function. In particular, e.g., it is possible to administer to a subject a pharmaceutical composition comprising a therapeutically effective amount of an agent that enhances Interleukin-6 (IL) release during exercise, and optionally a pharmaceutically acceptable carrier or excipient.
FILED	Monday, October 18, 2021
APPL NO	17/504116
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/06 (20180101) Peptides C07K 14/575 (20130101) Original (OR) Class C07K 2319/30 (20130101)
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20220106385 — USE OF MODIFIED HIV-1 FOR GENERATING FULLY HUMAN ANTIBODIES

US 20220106385	LUBAN
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Drug Abuse (NIDA)
APPLICANT(S)	UNIVERSITY OF MASSACHUSETTS (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S)	Jeremy LUBAN (Newton, Massachusetts)
ABSTRACT	The present invention provides highly efficient methods, and compositions related thereto, for generating high titer human antibodies or antibody fragments thereof in a mammalian subject. The methods comprise administering a virus or virus-like particle to a mammal comprising heterologous immune cells and isolating a population of immunoglobulin-producing cells from the mammal, thereby producing the antibodies or antibody fragments thereof.
FILED	Thursday, September 09, 2021
APPL NO	17/470463
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 39/12 (20130101) A61K 39/21 (20130101) A61K 39/0225 (20130101) Peptides C07K 16/1045 (20130101) C07K 16/1063 (20130101) Original (OR) Class C07K 16/1207 (20130101) C07K 2317/14 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2740/10044 (20130101) C12N 2740/16021 (20130101) C12N 2740/16023 (20130101) C12N 2740/16034 (20130101) C12N 2740/16043 (20130101) C12N 2740/16044 (20130101) C12N 2740/16122 (20130101) C12N 2740/16134 (20130101) C12N 2740/16322 (20130101)
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20220106406 — POLYPEPTIDE DIRECTED AGAINST PROTEIN TYROSINE PHOSPHATASE 4A PROTEINS, AND COMPOSITIONS AND METHODS FOR USE THEREOF

US 20220106406	Blackburn et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Kentucky Research Foundation (Lexington, Kentucky)
ASSIGNEE(S)
INVENTOR(S)	Jessica S. Blackburn (Harrodsburg, Kentucky); Caroline N. Smith (Richmond, Kentucky)
ABSTRACT	A protein tyrosine phosphatase 4A (PTP4A or PRL) targeting amino acid molecule is provided. The PRL targeting amino acid molecule includes an amino acid sequence according to one or more of NB91 (SEQ ID NO: 1), NB 13 (SEQ ID NO: 2), NB90 (SEQ ID NO: 3), NB4 (SEQ ID NO: 4), NB7 (SEQ ID NO: 5), NB10 (SEQ ID NO: 6), NB16 (SEQ ID NO: 7), NB18 (SEQ ID NO: 8), NB29 (SEQ ID NO: 9), NB19 (SEQ ID NO: 10), NB84 (SEQ ID NO: 11), NB92 (SEQ ID NO: 12), NB23 (SEQ ID NO: 13), NB26 (SEQ ID NO: 14), NB28 (SEQ ID NO: 15), NB68 (SEQ ID NO: 16), or a variant thereof. Also provided herein are methods of making and using the PRL targeting amino acid molecule.
FILED	Friday, October 01, 2021
APPL NO	17/492299
CURRENT CPC	Peptides C07K 16/40 (20130101) Original (OR) Class C07K 2317/569 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/104 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 2333/9108 (20130101)
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20220106417 — POLYMERIZATION PHOTOINHIBITOR

US 20220106417	Scott et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S)	The Regents of the University of Michigan (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S)	Timothy F. Scott (Ann Arbor, Michigan); Harry van der Laan (Ann Arbor, Michigan); Megan A. Cole (Ann Arbor, Michigan); Mark A. Burns (Ann Arbor, Michigan); Martin P. De Beer (Ann Arbor, Michigan); Zachary D. Pritchard (Ann Arbor, Michigan); Avi Bregman (Ann Arbor, Michigan)
ABSTRACT	Provided herein is technology relating to polymerization and producing polymers and particularly, but not exclusively, to methods, systems, and compositions for producing articles using three-dimensional printing and for improving control of polymerization using a polymerization photoinhibitor having fast back reaction kinetics such as hexaarylbiimidazole compounds and bridged hexaarylbiimidazole compounds.
FILED	Wednesday, October 13, 2021
APPL NO	17/500151
CURRENT CPC	Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/50 (20130101) Original (OR) Class C08F 4/04 (20130101) C08F 4/40 (20130101) C08F 222/40 (20130101)
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20220106547 — COMPOSITIONS AND METHODS OF USING PARTIAL GEL LAYERS IN A MICROFLUIDIC DEVICE

US 20220106547	Petropolis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Alcohol Abuse and Alcoholism (NIAAA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Emulate, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S)	Debora Barreiros Petropolis (Cambridge, Massachusetts); Remi Villenave (Boston, Massachusetts); Janna Nawroth (Boston, Massachusetts); Tanvi Shroff (Cambridge, Massachusetts); S. Jordan Kerns (Reading, Massachusetts); Antonio Varone (West Roxbury, Massachusetts)
ABSTRACT	The present invention relates to the use of gels for cell cultures, including but not limited to microfluidic devices and transwell devices, for culturing cells, such as organ cells, e.g. airway cells, intestinal cells, etc., and co-culturing cells, (e.g. parenchymal cells and endothelial cells, etc). As one example, the use of gels results in improved lung cell cultures, such as when using transwells and microfluidic devices, (e.g. for culturing healthy airway epithelial cells, culturing diseased airway epithelial cells, e.g., CF epithelial cells that are ciliated). The present invention relates to fluidic devices, methods and systems for use with gel layers within a microfluidic device. In particular, a partial gel layer is disposed within a microchannel of a microfluidic device. For example, a partial gel layer has a thickness ranging between approximately 20-100 μm. A dilute partial gel layer of less than 100 μm may be formed from a polymer solution of 0.5 mg/ml. A cell-permeable partial gel layer having a thickness ranging between approximately 20-50 μm may be formed from a polymer solution of 1-3 mg/ml. A partial gel layer may be formed by a hydrodynamic shearing technique. Such thin gel layers can support a variety of cell cultures, including but not limited to single cells, cell populations, cell layers, differentiated cell layers, and/or primary tissues. The present invention is related to the field of imaging and image processing. In particular, the invention is related to imaging that supports the determination of cell membrane cilia beating frequency. For example, methods described herein encompass cilia beat frequency in the context of membrane region and/or distances between regions. Alternatively, the methods described here encompass cilia beat synchrony and correlation of beat frequency between cell membrane regions.
FILED	Friday, October 29, 2021
APPL NO	17/514659
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0688 (20130101) C12N 2533/54 (20130101) C12N 2535/00 (20130101)
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20220106565 — MULTICELL CONJUGATES FOR ACTIVATING ANTIGEN-SPECIFIC T CELL RESPONSES

US 20220106565	Gumperz et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S)	Jenny Ellen Gumperz (Madison, Wisconsin); Dana Carina Baiu (Madison, Wisconsin)
ABSTRACT	The present invention provides in vitro derived a multicell conjugate comprising an iNKT cell and a dendritic cell (DC). The invention also provides methods of making the multicell conjugate and methods of using the multicell conjugate and compositions comprising the same to treat one or more conditions associated with an antigen or methods of activating an immune response.
FILED	Wednesday, October 06, 2021
APPL NO	17/495597
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/70532 (20130101) C07K 14/70575 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) Original (OR) Class C12N 2501/22 (20130101) C12N 2501/2304 (20130101)
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20220106566 — Antigen-Presenting Neutrophil-Derived Dendritic Cells and Methods of Use Thereof

US 20220106566	Mayadas et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S)	Tanya Mayadas (Jamaica Plain, Massachusetts); Vijaya Mysore (West Roxbury, Massachusetts); Xavier Cullere (Newton, Massachusetts); Jon C. Aster (Lexington, Massachusetts)
ABSTRACT	Methods and compositions for use in generating or promoting an immune response to cancer or an infection, comprising promoting differentiation of neutrophils into dendritic cells using a combination of GMCSF and (i) an immune complex comprising an antigen and an antibody comprising an Fc region that binds to FcγRIIA or FcγRIIIB, (ii) a conjugate comprising an antigen and an anti-FcγRIIIB antibody, or (iii) an anti-FcγRIIIB antibody.
FILED	Wednesday, January 22, 2020
APPL NO	17/424431
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) A61K 38/193 (20130101) A61K 39/0005 (20130101) A61K 47/6849 (20170801) A61K 2039/505 (20130101) A61K 2039/5154 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/283 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) Original (OR) Class C12N 2501/22 (20130101) C12N 2501/998 (20130101) C12N 2506/11 (20130101)
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20220106580 — TARGETED CHONDROITINASE ABC FUSION PROTEINS AND COMPLEXES THEREOF

US 20220106580	Hudalla et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S)	University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S)	Gregory Allan Hudalla (Gainesville, Florida); Benjamin G. Keselowsky (Gainesville, Florida); Dillon T. Seroski (Gainesville, Florida); Shaheen A. Farhadi (Gainesville, Florida); Christine E. Schmidt (Gainesville, Florida); Nikunj Kumar Agrawal (Gainesville, Florida)
ABSTRACT	Described herein are targeted ChABC fusion proteins, complexes thereof, and uses thereof. The targeted ChABC fusion proteins can include a ChABC polypeptide that can be linked to a Gal-3 polypeptide. Monomer targeted ChABC fusion proteins can form homogeneous or heterogeneous complexes. The targeted ChABC fusion proteins and complexes thereof can be formulated as pharmaceutical formulations. The targeted ChABC fusion proteins, complexes thereof, and formulations thereof can be administered to a subject in need thereof.
FILED	Friday, October 25, 2019
APPL NO	17/288435
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/88 (20130101) Original (OR) Class Enzymes C12Y 304/24035 (20130101) C12Y 402/0202 (20130101) C12Y 402/02004 (20130101) C12Y 402/02021 (20130101)
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20220106596 — A METHOD OF GENE EDITING

US 20220106596	RUSSELL et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S)	University of Washington (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S)	David W. RUSSELL (Seattle, Washington); Francoise J. HAESELEER (Seattle, Washington); Dhwanil DALWADI (Seattle, Washington)
ABSTRACT	Disclosed herein are methods of editing a gene in a cell that involve contacting the cell with a replication fork modulator, as well as edited cells and their methods of use.
FILED	Wednesday, January 29, 2020
APPL NO	17/423236
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) A61K 48/0066 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/90 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2750/14143 (20130101)
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20220106630 — Nanopore Platform for DNA/RNA Oligo Detection Using an Osmium Tagged Complementary Probe

US 20220106630	Kanavarioti
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Anastassia Kanavarioti (El Dorado Hills, California)
ASSIGNEE(S)
INVENTOR(S)	Anastassia Kanavarioti (El Dorado Hills, California)
ABSTRACT	Provided for herein is a method for detecting the presence of a nucleic acid target molecule in a biological sample. In certain aspects, the method comprises contacting a test sample that comprises (i) a biological sample comprising a nucleic acid target molecule and (ii) an osmylated single-stranded oligonucleotide probe comprising at least one pyrimidine residue covalently bonded to a substituted or unsubstituted Osmium tetroxide (OsO₄)-2,2′-bypyridine group (OsBp group).
FILED	Friday, September 03, 2021
APPL NO	17/466931
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6832 (20130101) Original (OR) Class
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20220107245 — METHODS FOR PREPARING LIVE CELLS FOR ANALYSIS AND DETERMINING LOCALIZATION OF MEMBRANE-BOUND PROTEINS

US 20220107245	Mattoo et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)
INVENTOR(S)	Seema Mattoo (West Lafayette, Indiana); Ranjan Sengupta (West Lafayette, Indiana); Michael Poderycki (West Lafayette, Indiana); Elaine Marie Mihelc (Philadelphia, Pennsylvania); Robert Virgil Stahelin (West Lafayette, Indiana)
ABSTRACT	Methods of preparing live cells for analysis, including methods that may be used with electron microscopy (EM) for localization of membrane proteins to achieve reduced morphological damage to cellular membranes and membrane-bound organelles. Such a method involves performing a chemical fixation process on a cellular sample comprising live cells, and then performing a cryofixation process with extended osmication during freeze substitution on the cellular sample.
FILED	Tuesday, July 20, 2021
APPL NO	17/381149
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 1/42 (20130101) G01N 23/06 (20130101) G01N 23/046 (20130101) G01N 2001/302 (20130101) G01N 2001/305 (20130101) G01N 2223/04 (20130101) G01N 2223/40 (20130101)
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20220107246 — NONCOVALENT TAGS AND RELATED METHODS FOR CYTOSOLIC DELIVERY OF MACROBIOMOLECULES

US 20220107246	Gao et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	University of Washington (Seattle, Washington)
ASSIGNEE(S)	University of Washington (Seattle, Washington)
INVENTOR(S)	Xiaohu Gao (Seattle, Washington); Wanyi Tai (Seattle, Washington)
ABSTRACT	The disclosure provides bifunctional tag constructs and related methods useful for transporting macrobiomolecules, such as nucleic acids and proteins, across plasma membranes. The bifunctional tags comprise an affinity domain conjugated to hydrophobic domain. The affinity domain is configured to noncovalently bind to the macrobiomolecule, whereas the hydrophobic domain is configured to interact with the plasma membrane. In certain embodiments, the plurality of bifunctional tags can noncovalently associate along the length of a macrobiomolecule, thus increasing the interaction with and penetration through the plasma membrane.
FILED	Friday, January 31, 2020
APPL NO	17/426448
CURRENT CPC	Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/53 (20130101) C12N 2310/111 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 2001/302 (20130101)
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20220107305 — Companion Diagnostics for NSAIDS and Donepezil for Treating Specific Subpopulations of Patients Suffering from Alzheimer's Disease

US 20220107305	O'Bryant
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Aging (NIA)
APPLICANT(S)	University of North Texas Health Science Center at Fort Worth (Fort Worth, Texas)
ASSIGNEE(S)
INVENTOR(S)	Sid E. O'Bryant (Aledo, Texas)
ABSTRACT	The present invention includes a method for identifying a patient response to treatment for Alzheimer's Disease with a non-steroidal anti-inflammatory drug (NSAID) or an acetylcholinesterase (AChE) inhibitor drug comprising: obtaining a blood or serum sample from the patient; determining the presence of a proinflammatory endophenotype in the blood or serum sample of the patient; using the proinflammatory endophenotype to detect treatment response (a responder, a stable, a non-responder or an adverse responder); and treating the patient with the NSAID or the AChE inhibitor if the patient is in the responder or the stable treatment response phenotype group; or preventing a treatment with the NSAID or the AChE inhibitor if the patient is a non-responder or an adverse responder.
FILED	Monday, January 14, 2019
APPL NO	16/962917
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5008 (20130101) Original (OR) Class G01N 33/6869 (20130101)
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20220107307 — UTILIZATION OF BLOOD COMPONENT-CONTAINING SOLUTIONS FOR BIOPROSTHETIC VALVE MANUFACTURE AND TESTING

US 20220107307	Ferrari et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York)
ASSIGNEE(S)
INVENTOR(S)	Giovanni Ferrari (Hastings on Hudson, New York); Antonio Frasca (Bronx, New York)
ABSTRACT	Compositions and methods for testing BHV for performance or longevity are provided.
FILED	Tuesday, October 12, 2021
APPL NO	17/499511
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2472 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/66 (20130101) G01N 33/68 (20130101) G01N 33/5306 (20130101) Original (OR) Class
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20220107316 — DETECTION OF HUMAN LEUKOCYTE ANTIGEN-A*32:01 IN CONNECTION WITH DETERMINING DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) AND METHODS OF TREATING BACTERIAL INFECTION IN A SUBJECT WITH VANCOMYCIN-INDUCED DRESS

US 20220107316	Phillips et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of General Medical Sciences (NIGMS)
APPLICANT(S)	VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S)	Elizabeth Phillips (Nashville, Tennessee); Simon Mallal (Nashville, Tennessee); Katherine Konvinse (Nashville, Tennessee); Abha Chopra (Nashville, Tennessee)
ABSTRACT	Methods of detecting a human leukocyte antigen (HLA)-A*32:01 allele in a subject as disclosed are useful, for example, to determine whether the subject is at risk for developing or has vancomycin-induced drug reaction with eosinophilia and systemic symptoms (DRESS). Methods of treating bacterial infection in a subject with vancomycin-induced DRESS are also disclosed.
FILED	Friday, February 14, 2020
APPL NO	17/427887
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56977 (20130101) Original (OR) Class G01N 2333/70539 (20130101) G01N 2800/24 (20130101)
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20220107321 — Cancer Progression Risk Assessment by Microvascular Phenotype

US 20220107321	Tlsty et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Thea Tlsty (San Francisco, California); Joseph Caruso (San Francisco, California); Karla Kerlikowske (San Anselmo, California); Annette Molinaro (San Francisco, California); RosaAnna DeFilippis (San Francisco, California)
ABSTRACT	Repression of CD36 vasculature in stromal tissues surrounding a pre-cancerous lesion provides is indicative of increased risk of subsequent progression to invasive cancer. Methods of assessing progression risk by measuring the abundance of CD36 vasculature in stromal tissues surrounding a precancerous lesion are provided, useful for various cancer types, including for assessing the risk of DCIS progression to breast cancer. Immunohistochemical analysis methods and diagnostic thresholds are provided, as well as associated methods of treatment and diagnostic kits.
FILED	Thursday, January 16, 2020
APPL NO	17/423583
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 33/57415 (20130101) Original (OR) Class G01N 2333/70596 (20130101)
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20220107327 — MULTI-TARGET CROSSLINKERS AND USES THEREOF

US 20220107327	Wang et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) National Institute of Mental Health (NIMH)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S)	Lei Wang (San Francisco, California); Bing Yang (San Francisco, California); Haifan Wu (San Francisco, California); William DeGrado (San Francisco, California); Jun Liu (San Francisco, California)
ABSTRACT	Disclosed herein, inter alia, are compositions and methods for cross-linking biomolecules. In an aspect is provided a method of detecting a covalently conjugated molecule, the method including i) contacting a first biomolecule and a second biomolecule with a crosslinking agent to form a covalently conjugated biomolecule; ii) identifying a first point of attachment of the crosslinking agent to the first biomolecule using mass spectroscopy; and iii) identifying a second point of attachment of the crosslinking agent to the second biomolecule using mass spectroscopy; thereby detecting a covalently conjugated molecule.
FILED	Wednesday, October 02, 2019
APPL NO	17/281179
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) Original (OR) Class G01N 2560/00 (20130101)
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20220107329 — METHODS OF DETECTING AND DIAGNOSING DEFECTS OF THE LYMPHATIC VASCULATURE

US 20220107329	Oliver et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S)	NORTHWESTERN UNIVERSITY (Evanston, Illinois); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California)
ASSIGNEE(S)
INVENTOR(S)	Guillermo Oliver (Chicago, Illinois); Stanley Rockson (Stanford, California)
ABSTRACT	Disclosed herein are methods and compositions useful for identifying and treating diseases, conditions, and abnormalities of the lymphatic vasculature. In some embodiments, the methods include determining a level of platelet factor 4 (PF4) in a biological sample of the subject, and diagnosing the subject as having a disease or condition of the lymphatic vasculature if the subject's PF4 level is increased compared to a control PF4 level. Also disclosed herein are method of treating a subject having an increased PF4 level. In some embodiments, the methods include administering a composition comprising a molecule that specifically binds to and inhibits the function of PF4, such as, for example, an antibody. In some embodiments, the subject has previously been diagnosed with obesity.
FILED	Wednesday, September 29, 2021
APPL NO	17/489467
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/86 (20130101) Original (OR) Class G01N 2333/521 (20130101)
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20220108123 — TISSUE MICROENVIRONMENT ANALYSIS BASED ON TIERED CLASSIFICATION AND CLUSTERING ANALYSIS OF DIGITAL PATHOLOGY IMAGES

US 20220108123	Bhargava et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S)	The Board of Trustees of the University of Illinois (Urbana, Illinois)
ASSIGNEE(S)
INVENTOR(S)	Rohit Bhargava (Urbana, Illinois); Shachi Mittal (Urbana, Illinois)
ABSTRACT	Segmentation or other classification of digital pathology images with a deep learning model allows for sophisticated spatial features for cancer diagnosis to be extracted in an automated, fast, and accurate manner. A tiered analysis of tissue structure based in part on deep learning methods is provided. First, tissues depicted in a digital pathology image are segmented into cellular compartments (e.g., epithelial and stromal compartments). Second, the heterogeneity in the different cellular compartments are examined based on a clustering algorithm. Tissue can then be characterized in terms of inertia (or other spatial measures or features), which can be used to recognize disease. In some instances, multidimensional inertia (i.e., inertia computed in different cellular compartments or clustered components) can be used as an indicator of disease and its outcome.
FILED	Friday, October 01, 2021
APPL NO	17/449774
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/46 (20130101) G06K 9/628 (20130101) Original (OR) Class G06K 9/00979 (20130101) G06K 9/6223 (20130101) G06K 2209/05 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0012 (20130101) G06T 2207/20084 (20130101) G06T 2207/30068 (20130101) G06T 2207/30096 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 15/00 (20180101) G16H 30/40 (20180101)
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Department of Energy (DOE)

20220105186 — Compositions Containing Nucleosides and Manganese and Their Uses

US 20220105186	Daly et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Energy (DOE) Office of Science (DOE-SC) Environmental Remediation Sciences Program (ERSP) Department of Health and Human Services (HHS)
APPLICANT(S)	The Henry M. Jackson Foundation for the Advancement of Military Medice, Inc. (Besthesda, Maryland); The Government of the USA as Represented by the Secretary Department of Health and Human Services (Rockville, Maryland)
ASSIGNEE(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Government of the USA as Represented by the Secretary Department of Health and Human Services (Rockville, Maryland)
INVENTOR(S)	Michael J. Daly (Washington, District of Columbia); Elena K. Gaidamakova (Gaithersburg, Maryland); Vera Y. Matrosova (Rockville, Maryland); Rodney L. Levine (Rockville, Maryland); Nancy B. Wehr (Bethesda, Maryland)
ABSTRACT	This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.
FILED	Tuesday, November 02, 2021
APPL NO	17/517148
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 8/24 (20130101) A61K 8/44 (20130101) A61K 8/99 (20130101) A61K 8/606 (20130101) A61K 31/7072 (20130101) A61K 31/7076 (20130101) A61K 33/32 (20130101) A61K 35/74 (20130101) A61K 45/06 (20130101) Original (OR) Class Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101)
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20220105461 — SYSTEM AND METHOD FOR INTEGRATED ABSORBER INTERCOOLING VIA RICH SOLVENT STREAM USING 3D-PRINTED ACTIVE PACKINGS

US 20220105461	MOORE et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Lawrence Livermore National Security, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S)	Thomas Charles Reading MOORE (Livermore, California); Joshuah K. STOLAROFF (Oakland, California)
ABSTRACT	The present disclosure relates to an absorber column apparatus for removing a selected component of a gas. The apparatus may have a first zone, a second zone and a third zone, wherein the first and third zones form a first domain through which a first fluid laden with a select gaseous component to be removed therefrom flows along concurrently with a second fluid. The second fluid at least substantially removes the select gaseous component from the first fluid to create a third fluid. The first fluid leaves the absorber column as a fourth fluid with the select gaseous component at least substantially removed therefrom. The second zone forms an active packing zone including a structure which forms an independent second domain in thermal communication with the first domain. The second receives a quantity of the third fluid and channels it through the second zone to help cool at least one of the first and second fluids.
FILED	Tuesday, October 06, 2020
APPL NO	17/064174
CURRENT CPC	Separation B01D 53/18 (20130101) Original (OR) Class B01D 53/1462 (20130101) B01D 2257/504 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/30 (20130101)
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20220105475 — ENZYMATICALLY ACTIVE HIGH-FLUX SELECTIVELY GAS-PERMEABLE MEMBRANES FOR ENHANCED OIL RECOVERY AND CARBON CAPTURE

US 20220105475	REMPE et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico); NATIONAL TECHNOLOGY and ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Susan Lynne REMPE (Albuquerque, New Mexico); Ying-Bing JIANG (Albuquerque, New Mexico); Juan VANEGAS (Albuquerque, New Mexico); C. Jeffrey BRINKER (Albuquerque, New Mexico); Joseph L. CECCHI (Albuquerque, New Mexico)
ABSTRACT	A membrane structure for moving a gaseous object species from a first region having an object species first concentration, through the membrane structure, to a second region having an object species second concentration different from the first concentration is described. The membrane includes a supporting substrate having a plurality of pores therethrough, each of the plurality of pores defined by a first end, a second end and a surface of the supporting substrate extending between the first end and the second end as well as a nanoporous layer within the plurality of pores, wherein the nanoporous layer comprises a hydrophilic layer and a hydrophobic layer. The membrane also includes a liquid transport medium within the hydrophilic layer. The liquid transport medium includes a liquideous permeation medium and at least one enzyme within the liquideous permeation medium. The at least one enzyme is reinforced by at least one stabilizing component.
FILED	Wednesday, December 15, 2021
APPL NO	17/551826
CURRENT CPC	Separation B01D 53/62 (20130101) B01D 53/228 (20130101) B01D 67/0037 (20130101) B01D 69/10 (20130101) B01D 69/144 (20130101) Original (OR) Class B01D 2255/804 (20130101) B01D 2257/504 (20130101) B01D 2325/36 (20130101) B01D 2325/38 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/18 (20130101) C12M 25/02 (20130101)
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20220105498 — RUTHENIUM-TRANSITION METAL ALLOY CATALYSTS

US 20220105498	WANG et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S)	CORNELL UNIVERSITY (Ithaca, New York)
INVENTOR(S)	Hongsen WANG (Ithaca, New York); Héctor D. ABRUÑA (Ithaca, New York)
ABSTRACT	Provided is a catalytically active particle comprising an alloy, said alloy comprising: greater than or equal to 50 atomic % ruthenium (Ru); and 1 to 50 atomic % of one or more transition metals (M) selected from cobalt (Co), nickel (Ni), and iron (Fe), wherein the sum of the atomic percentages of Ru and M is greater than 65 atomic % of the alloy, and wherein, in the particle, the alloy is not fully or partially encapsulated by a layer of platinum atoms. Devices and processes employing the catalytically active particle are also provided.
FILED	Tuesday, March 17, 2020
APPL NO	17/430613
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/18 (20130101) B01J 23/8913 (20130101) Original (OR) Class Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 9/19 (20210101) C25B 11/065 (20210101) C25B 11/089 (20210101) C25B 13/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/9058 (20130101) H01M 4/9083 (20130101) H01M 8/1004 (20130101)
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20220105569 — Site-Specific Melt Pool Size Control in Additive Manufacturing

US 20220105569	Gibson et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S)	Brian T. Gibson (Knoxville, Tennessee); Bradley Scott Richardson (Knoxville, Tennessee); Lonnie J. Love (Knoxville, Tennessee); Paritosh Mhatre (Knoxville, Tennessee); Michael Borish (Knoxville, Tennessee)
ABSTRACT	Closed-loop melt pool size control for additive manufacturing is integrated with site-specific changes to a controller set-point. Site-specific control enables localized control of bead geometry and material properties in an additive manufacturing system, thus offering enhanced defect mitigation capabilities when compared with constant setpoint technologies. Trigger points, generated by the projection of a secondary geometry onto a primary geometry, mark locations of the volume of a part under manufacture where site-specific changes in setpoint occur. Through this technique, it is possible to manufacture a specific geometry that occurs beyond a predefined toolpath of a print head. Implications of this capability extend beyond localized control of bead geometry to potential mitigations of defects and functional grading of component properties.
FILED	Friday, September 17, 2021
APPL NO	17/478842
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/85 (20210101) Original (OR) Class B22F 12/90 (20210101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/08 (20130101) B23K 26/032 (20130101) B23K 26/034 (20130101) B23K 26/342 (20151001) B23K 26/0626 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/02 (20141201)
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20220106197 — Preparation of metal chalcogenides

US 20220106197	Balema et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Ames Laboratory (AL) Federally Funded Research and Development Center (FFRDC) Operated by Iowa State University (IASTATE) at Ames, IA
APPLICANT(S)	Iowa State University Research Foundation, Inc. (Ames, Iowa)
ASSIGNEE(S)
INVENTOR(S)	Viktor Balema (Muskego, Wisconsin); Ihor Hlova (Ames, Iowa); Vitalij K. Pecharsky (Ames, Iowa)
ABSTRACT	A method embodiment involves preparing single metal or mixed transition metal chalcogenide using exfoliation of two or more different bulk transition metal dichalcogenides in a manner to form an intermediate hetero-layered transition metal chalcogenide structure, which can be treated to provide a single-phase transition metal chalcogenide.
FILED	Monday, November 01, 2021
APPL NO	17/300772
CURRENT CPC	Crushing, Pulverising, or Disintegrating in General; Milling Grain B02C 15/004 (20130101) B02C 19/06 (20130101) Non-metallic Elements; Compounds Thereof; C01B 19/002 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 39/06 (20130101) Original (OR) Class C01G 41/00 (20130101) C01G 41/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/01 (20130101) C01P 2002/72 (20130101) C01P 2002/85 (20130101) C01P 2002/88 (20130101) C01P 2004/03 (20130101) C01P 2004/04 (20130101) C01P 2004/20 (20130101) C01P 2004/30 (20130101)
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20220106442 — BIODERIVED RECYCLABLE EPOXY-ANHYDRIDE THERMOSETTING POLYMERS AND RESINS

US 20220106442	WANG et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S)	Chen WANG (Superior, Colorado); Robynne E. MURRAY (Superior, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); Scott MAUGER (Arvada, Colorado); Nicholas A. RORRER (Golden, Colorado)
ABSTRACT	The present disclosure relates to a composition that includes a structure that includes where R₁includes at least one of a carbon atom and/or an oxygen atom, R²includes at least one of a carbon atom and/or an oxygen atom, and represents a covalent bond. In some embodiments of the present disclosure, the composition may be bioderived.
FILED	Tuesday, October 05, 2021
APPL NO	17/494514
CURRENT CPC	Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 7/12 (20130101) B32B 17/10 (20130101) B32B 27/08 (20130101) B32B 27/32 (20130101) B32B 27/36 (20130101) B32B 27/38 (20130101) B32B 27/306 (20130101) B32B 2255/10 (20130101) B32B 2255/26 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 67/04 (20130101) Original (OR) Class C08G 2230/00 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 11/24 (20130101) C08J 2373/02 (20130101) C08J 2423/04 (20130101) C08J 2423/10 (20130101) C08J 2429/04 (20130101) C08J 2467/00 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/04 (20130101) C08K 7/06 (20130101) C08K 7/14 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 173/02 (20130101)
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20220106516 — Super-Hydrophobic, Thermally Insulating, Thermal-Shocks Resistant Well Cement Composites for Completion of Geothermal Wells at Hydrothermal Temperatures of Up to 300 Degrees C

US 20220106516	Pyatina et al.
FUNDED BY	Department of Energy (DOE) Brookhaven Science Associates, LLC (BSA) Office of Science (DOE-SC) Brookhaven National Laboratory (BNL) Federally Funded Research and Development Center (FFRDC) Operated by Brookhaven Science Associates, LLC (BSA) at Upton, NY
APPLICANT(S)	Brookhaven Science Associates, LLC (Upton, New York)
ASSIGNEE(S)
INVENTOR(S)	Tatiana Pyatina (Stony Brook, New York); Toshifumi Sugama (Wading River, New York)
ABSTRACT	A well cement composite and a method for making a well cement composite includes a mixture of calcium aluminate cement (CAC) and fly ash cenospheres (CS) in a weight ratio of from 30:70 to 80:20 CAC to CS; sodium metasilicate (SMS) in an amount of from 1 to 10% of the total weight of the mixture of CAC and CS; polymethylhydrosiloxane (PMHS) in an amount of from 0.5 to 6.0% of the total weight of the mixture of CAC and CS; and water in a weight ratio of from 0.5:1.0 to 1.2:1.0 of water to CAC and CS.
FILED	Tuesday, October 05, 2021
APPL NO	17/494477
CURRENT CPC	Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 20/1037 (20130101) C04B 24/42 (20130101) C04B 28/26 (20130101) C04B 40/0042 (20130101) C04B 2201/20 (20130101) C04B 2201/32 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 8/467 (20130101) Original (OR) Class
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20220106522 — Optical Tags Comprising Rare Earth Metal-Organic Frameworks

US 20220106522	Sava Gallis et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Dorina F. Sava Gallis (Albuquerque, New Mexico); Kimberly Butler (Albuquerque, New Mexico); Lauren E. S. Rohwer (Albuquerque, New Mexico)
ABSTRACT	Optical tags provide a way to identify assets quickly and unambiguously, an application relevant to anti-counterfeiting and protection of valuable resources or information. The present invention is directed to a tag fluorophore that encodes multilayer complexity in a family of heterometallic rare-earth metal-organic frameworks (RE-MOFs) based on highly connected polynuclear clusters and carboxylic acid-based linkers. Both overt (visible) and covert (near infrared, NIR) properties with concomitant multi-emissive spectra and tunable luminescence lifetimes impart both intricacy and security. Tag authentication can be validated with a variety of orthogonal detection methodologies. The relationships between structure, composition, and optical properties of the family of RE-MOFs can be used to create a large library of rationally designed, highly complex, difficult to counterfeit optical tags.
FILED	Monday, September 20, 2021
APPL NO	17/479710
CURRENT CPC	Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/003 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) Original (OR) Class C09K 2211/10 (20130101) C09K 2211/182 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6439 (20130101)
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20220106535 — Lubricating Base Oils from Esterified Alkoxylated Polyols Using Saturated Long-Chain Fatty Acids

US 20220106535	Hunt et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) National Science Foundation (NSF) Directorate of Technology Translational Impacts (TI) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Tetramer Technologies, LLC (Pendleton, South Carolina)
ASSIGNEE(S)	Tetramer Technologies, LLC (Pendleton, South Carolina)
INVENTOR(S)	Zachary Hunt (Simpsonville, South Carolina); Peter Gennaro (Mount Pleasant, South Carolina); Jeffrey R. DiMaio (Pendleton, South Carolina); Benjamin Bergmann (Liberty, South Carolina)
ABSTRACT	The present disclosure relates to methods and compositions for making bio-based, biodegradable, and non-bioaccumulating lubricating base oils generated by esterifying alkoxylated polyols (average alkoxylation ≥3) with long-chain (≥C14) saturated and unsaturated fatty acids (FA) or fatty acids modified using industry recognized techniques.
FILED	Thursday, December 16, 2021
APPL NO	17/552418
CURRENT CPC	Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 101/04 (20130101) C10M 105/44 (20130101) Original (OR) Class C10M 2207/301 (20130101) C10M 2209/043 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2040/04 (20130101)
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20220107254 — HIGH THROUGHPUT TRIBOMETER

US 20220107254	Nation et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Brendan L. Nation (Albuquerque, New Mexico); Michael T. Dugger (Tijeras, New Mexico); John Curry (Albuquerque, New Mexico)
ABSTRACT	The present invention relates, in part, to systems for characterizing force (e.g., friction, and wear). In one embodiment, a tribometer allows for wear testing of samples in a high throughput manner.
FILED	Monday, November 01, 2021
APPL NO	17/515815
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/04 (20130101) G01N 3/56 (20130101) Original (OR) Class G01N 3/165 (20130101)
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20220107272 — Coated Fiber Optic Chemical and Radiation Sensors

US 20220107272	LAMBERTI et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) National Security Complex and PANTEX Plant (Y-12) NNSA Critical Mission Site Operated by Consolidated Nuclear Security, LLC at Oak Ridge, TN (CNS)
APPLICANT(S)	Consolidated Nuclear Security, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S)	Vincent E. LAMBERTI (Oak Ridge, Tennessee); Dayakar PENUMADU (Knoxville, Tennessee)
ABSTRACT	Distributed fiber optic chemical and radiation sensors formed by coating the fibers with certain types of response materials are provided. For distributed chemical sensors, the coatings are reactive with the targets; the heat absorbed or released during a reaction will cause a local temperature change on the fiber. For distributed radiation sensors, coating a fiber with a scintillator enhances sensitivity toward thermal neutrons, for example, by injecting light into the fiber. The luminescent components in these materials are taken from conjugated polymeric and oligomeric dyes, metal organic frameworks with sorbed dyes, and two-photon-absorbing semiconductors. The compositions may exhibit strong gamma rejection. Other scintillators combining luminescent materials with neutron converters are available. With a multiple-layer coating, it may be possible to identify the presence of both neutrons and gamma rays, for example. Coatings may be applied during manufacture or in the field.
FILED	Thursday, October 01, 2020
APPL NO	17/060253
CURRENT CPC	Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 25/1065 (20130101) Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 3/047 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/7703 (20130101) Original (OR) Class Measurement of Nuclear or X-radiation G01T 3/06 (20130101) Optical Elements, Systems, or Apparatus G02B 6/03694 (20130101)
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20220107273 — Coated Fiber Optic Chemical and Radiation Sensors

US 20220107273	Lamberti et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) National Security Complex and PANTEX Plant (Y-12) NNSA Critical Mission Site Operated by Consolidated Nuclear Security, LLC at Oak Ridge, TN (CNS)
APPLICANT(S)	Consolidated Nuclear Security, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S)	Vincent E. Lamberti (Oak Ridge, Tennessee); Dayakar Penumadu (Knoxville, Tennessee)
ABSTRACT	Distributed fiber optic sensors formed by covering the fibers with tubing are provided. The tubing including responsive materials formulated or configured to, responsive to exposure to one of a target chemical species and a target radiation particle, change a relative size and generate a localized effect on or in the optical fiber.
FILED	Monday, November 02, 2020
APPL NO	17/086782
CURRENT CPC	Measuring Not Specially Adapted for a Specific Variable; Arrangements for Measuring Two or More Variables Not Covered in a Single Other Subclass; Tariff Metering Apparatus; Measuring or Testing Not Otherwise Provided for G01D 5/35361 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/7703 (20130101) Original (OR) Class G01N 2021/7716 (20130101) Measurement of Nuclear or X-radiation G01T 1/201 (20130101) Optical Elements, Systems, or Apparatus G02B 6/02104 (20130101)
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20220107281 — VARIABLE GAP THERMAL CONDUCTIVITY APPARATUS AND METHOD

US 20220107281	Gallagher et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Oak Ridge National Laboratory (ORNL) Federally Funded Research and Development Center (FFRDC) Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S)	UT-Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S)	Ryan C. Gallagher (Oak Ridge, Tennessee); Nora D. Ezell (Oak Ridge, Tennessee); Austin S. Chapel (Oak Ridge, Tennessee); Nicholas G. Russell (Oak Ridge, Tennessee)
ABSTRACT	An apparatus and a method for determining the thermal conductivity of a fluid specimen are provided. The apparatus and the method include determining thermal conductivity using a quasi-steady state variable gap axial flow technique. The fluid specimen is heated on one side by a heat source with a known power output and cooled on the other side. After reaching steady state, a resulting temperature drop through the fluid specimen exists. This temperature drop, the known fluid specimen thickness (or gap distance), and the known power output are used to calculate the thermal resistance of the fluid specimen. The thermal conductivity of the fluid specimen is then determined using a curve fit of thermal resistance with respect to gap distance.
FILED	Friday, September 24, 2021
APPL NO	17/484566
CURRENT CPC	Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 17/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/18 (20130101) Original (OR) Class G01N 25/20 (20130101)
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20220107283 — CHARACTERIZATION OF FLUID INSIDE PIPE USING MULTI FREQUENCY ELECTRICAL SIGNAL

US 20220107283	Chillara et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Los Alamos National Laboratory (LANL) Federally Funded Research and Development Center (FFRDC) Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S)	Triad National Security, LLC (Los Alamos, New Mexico); Chevron U.S.A. Inc. (San Ramon, California)
ASSIGNEE(S)
INVENTOR(S)	Vamshi Krishna Chillara (Los Alamos, New Mexico); Maruti Kumar Mudunuru (Los Alamos, New Mexico); Hari Selvi Viswanathan (Los Alamos, New Mexico); Satish Karra (Los Alamos, New Mexico); Bulbul Ahmmed (Los Alamos, New Mexico); Jeffrey Foering App (Houston, Texas); Gary Michael Hoversten (Los Alamos, New Mexico)
ABSTRACT	A multi-frequency signal may be used to induce voltage difference across a portion of a pipe. The voltage difference may be induced to take multi-frequency measurement of impedance characteristics of fluid inside the pipe. The multi-frequency measurement of the impedance characteristic of the fluid inside the pipe may be used to determine a characteristic of the fluid inside the pipe. This may be achieved by active integration of experimental data with high-resolution multi-frequency electrical impedance tomography (MFEIT) modeling.
FILED	Friday, October 02, 2020
APPL NO	16/948851
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/028 (20130101) Original (OR) Class G01N 33/2823 (20130101)
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20220107366 — OPTICAL MONITORING TO DETECT CONTAMINATION OF POWER GRID COMPONENTS

US 20220107366	Mostafavi et al.
FUNDED BY	Department of Energy (DOE) Office of Fossil Energy and Carbon Management (FECM) National Energy Technology Laboratory (NETL) Office of Electricity (DOE-OE)
APPLICANT(S)	Palo Alto Research Center Incorporated (Palo Alto, California)
ASSIGNEE(S)
INVENTOR(S)	Saman Mostafavi (Charlotte, North Carolina); Hong Yu (Fremont, California); Ajay Raghavan (Mountain View, California); Peter Kiesel (Palo Alto, California)
ABSTRACT	A monitoring system includes an array of optical sensors disposed within a transformer tank. Each optical sensor is configured to have an optical output that changes in response to a temperature within the transformer tank. An analyzer is coupled to the array of optical sensors. The analyzer is configured to determine a sensed temperature distribution based on the sensed temperature. The sensed temperature distribution is compared to an expected distribution. Exterior contamination of the transformer tank is detected based on the comparison.
FILED	Thursday, October 28, 2021
APPL NO	17/513255
CURRENT CPC	Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/1895 (20130101) Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/246 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 17/00 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 1/28 (20130101) G01R 19/2513 (20130101) G01R 29/20 (20130101) G01R 31/52 (20200101) G01R 31/62 (20200101) Original (OR) Class G01R 31/72 (20200101) G01R 31/346 (20130101) G01R 35/02 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/02 (20130101) H01F 27/08 (20130101) Transmission H04B 3/46 (20130101)
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20220107463 — Fiber Attach Enabled Wafer Level Fanout

US 20220107463	Ardalan et al.
FUNDED BY	Department of Energy (DOE) Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S)	Ayar Labs, Inc. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S)	Shahab Ardalan (Santa Clara, California); Michael Davenport (Santa Barbara, California); Roy Edward Meade (Lafayette, California)
ABSTRACT	A package assembly includes a silicon photonics chip having an optical waveguide exposed at a first side of the chip and an optical fiber coupling region formed along the first side of the chip. The package assembly includes a mold compound structure formed to extend around second, third, and fourth sides of the chip. The mold compound structure has a vertical thickness substantially equal to a vertical thickness of the chip. The package assembly includes a redistribution layer formed over the chip and over a portion of the mold compound structure. The redistribution layer includes electrically conductive interconnect structures to provide fanout of electrical contacts on the chip to corresponding electrical contacts on the redistribution layer. The redistribution layer is formed to leave the optical fiber coupling region exposed. An optical fiber is connected to the optical fiber coupling region in optical alignment with the optical waveguide within the chip.
FILED	Monday, November 01, 2021
APPL NO	17/516602
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/30 (20130101) Original (OR) Class G02B 6/122 (20130101) G02B 6/428 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/565 (20130101)
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20220107849 — APPARATUS AND METHOD FOR PROVIDING WORKLOAD DISTRIBUTION OF THREADS AMONG MULTIPLE COMPUTE UNITS

US 20220107849	RAO et al.
FUNDED BY	Department of Energy (DOE) Exascale Computing Project (ECP) PathForward Project (PATHFORWARD) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	Advanced Micro Devices, Inc. (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S)	KARTHIK RAO (Austin, Texas); SHOMIT N. DAS (Austin, Texas); XUDONG AN (Austin, Texas); WEI HUANG (Dallas, Texas)
ABSTRACT	In some examples, thermal aware optimization logic determines a characteristic (e.g., a workload or type) of a wavefront (e.g., multiple threads). For example, the characteristic indicates whether the wavefront is compute intensive, memory intensive, mixed, and/or another type of wavefront. The thermal aware optimization logic determines temperature information for one or more compute units (CUs) in one or more processing cores. The temperature information includes predictive thermal information indicating expected temperatures corresponding to the one or more CUs and historical thermal information indicating current or past thermal temperatures of at least a portion of a graphics processing unit (GPU). The logic selects the one or more compute units to process the plurality of threads based on the determined characteristic and the temperature information. The logic provides instructions to the selected subset of the plurality of CUs to execute the wavefront.
FILED	Thursday, November 04, 2021
APPL NO	17/519290
CURRENT CPC	Electric Digital Data Processing G06F 1/3206 (20130101) G06F 9/3867 (20130101) G06F 9/3877 (20130101) G06F 9/4893 (20130101) G06F 9/5027 (20130101) G06F 9/5094 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101)
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20220108434 — DEEP LEARNING FOR DEFECT DETECTION IN HIGH-RELIABILITY COMPONENTS

US 20220108434	Donahue et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia National Laboratories (SNL) Federally Funded Research and Development Center (FFRDC) Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S)	National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S)	Emily Donahue (Albuquerque, New Mexico); Tu-Thach Quach (Albuquerque, New Mexico); Christian Turner (Albuquerque, New Mexico); Kevin M. Potter (ALbuquerque, New Mexico)
ABSTRACT	A computer-implement method for training a neural network to detect defects is provided. The method comprises encoding, by an encoder, a real image of an object to produce a first compressed image as a first vector in a latent space, wherein the real image is free of defects. A decoder then generates a reconstructed image from the first vector in the latent space, wherein the reconstructed image is a closest non-anomalous reconstruction of the real image. A discriminator compares the real image and the reconstructed image and determines which image is the real image and which image is the reconstructed image. The encoder also encodes the reconstructed image to produce a second compressed image as a second vector in the latent space.
FILED	Wednesday, February 03, 2021
APPL NO	17/166166
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6202 (20130101) Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) G06N 3/0454 (20130101) Image Data Processing or Generation, in General G06T 7/0002 (20130101) Original (OR) Class G06T 2207/10081 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101)
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20220108807 — APPLICATION OF COMPRESSED MAGNETIC FIELDS TO THE IGNITION AND THERMONUCLEAR BURN OF INERTIAL CONFINEMENT FUSION TARGETS

US 20220108807	Perkins et al.
FUNDED BY	Department of Energy (DOE) National Nuclear Security Administration (NNSA) Lawrence Livermore National Laboratory (LLNL) Federally Funded Research and Development Center (FFRDC) Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S)	LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California)
ASSIGNEE(S)
INVENTOR(S)	Lindsay John Perkins (Pleasanton, California); Jim H. Hammer (Livermore, California); John H. Moody (Livermore, California); Max Tabak (Livermore, California); Burl Grant Logan (Danville, California)
ABSTRACT	Application of axial seed magnetic fields in the range 20-100 T that compress to greater than 10,000 T (100 MG) under typical NIF implosion conditions may significantly relax the conditions required for ignition and propagating burn in NIF ignition targets that are degraded by hydrodynamic instabilities. Such magnetic fields can: (a) permit the recovery of ignition, or at least significant alpha particle heating, in submarginal NIF targets that would otherwise fail because of adverse hydrodynamic instability growth, (b) permit the attainment of ignition in conventional cryogenic layered solid-DT targets redesigned to operate under reduced drive conditions, (c) permit the attainment of volumetric ignition in simpler, room-temperature single-shell DT gas capsules, and (d) ameliorate adverse hohlraum plasma conditions during laser drive and capsule compression. In general, an applied magnetic field should always improve the ignition condition for any NIF ignition target design.
FILED	Tuesday, December 14, 2021
APPL NO	17/644292
CURRENT CPC	Fusion Reactors G21B 1/03 (20130101) G21B 1/05 (20130101) Original (OR) Class G21B 1/19 (20130101)
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20220108808 — CONTROL RODS FOR LIGHT WATER REACTORS

US 20220108808	LAHODA et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE)
APPLICANT(S)	Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania)
ASSIGNEE(S)	Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania)
INVENTOR(S)	Edward J. LAHODA (Edgewood, Pennsylvania); Frank A. BOYLAN (Ellewood City, Pennsylvania); Ho Q. LAM (Verona, Pennsylvania); Mitchell E. NISSLEY (Trafford, Pennsylvania); Raymond E. SCHNEIDER (South Windsor, Connecticut); Robert L. OELRICH (Columbia, South Carolina); Sumit RAY (Columbia, South Carolina); Radu POMIRLEANU (Wexford, Pennsylvania); Zeses KAROUTAS (Lexington, South Carolina); Michael J. HONE (Prospect, Pennsylvania)
ABSTRACT	A control rod for a nuclear fuel assembly is described herein that includes a neutron absorbing material having a melting point greater than 1500° C. that does not form a eutectic with a melting point less than 1500° C., and may further include a cladding material having a melting point greater than 1500° C. The cladding material is selected from the group consisting of silicon carbide, zirconium, a zirconium alloy, tungsten, and molybdenum. The absorbing material is selected from the group consisting of Gd₂O₃, Ir, B₄C, Re, and Hf. The metal cladding or the absorbing material may be coated with an anti-oxidation coating of Cr with or without a Nb intermediate layer.
FILED	Tuesday, November 09, 2021
APPL NO	17/454196
CURRENT CPC	Nuclear Reactors G21C 3/07 (20130101) G21C 7/10 (20130101) G21C 7/24 (20130101) Original (OR) Class
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20220108809 — IN-CORE INSTRUMENTATION

US 20220108809	Keller et al.
FUNDED BY	Department of Energy (DOE) Office of Nuclear Energy (DOE-NE)
APPLICANT(S)	NuScale Power, LLC (Portland, Oregon)
ASSIGNEE(S)
INVENTOR(S)	Michael Keller (Portland, Oregon); Ross I. Snuggerud (Portland, Oregon)
ABSTRACT	An in-core instrumentation system for a reactor module includes a plurality of in-core instruments connected to a containment vessel and a reactor pressure vessel at least partially located within the containment vessel. A reactor core is housed within a lower head that is removably attached to the reactor pressure vessel, and lower ends of the in-core instruments are located within the reactor core. The in-core instruments are configured such that the lower ends are concurrently removed from the reactor core as a result of removing the lower head from the reactor pressure vessel.
FILED	Friday, December 17, 2021
APPL NO	17/554967
CURRENT CPC	Nuclear Reactors G21C 1/08 (20130101) G21C 1/32 (20130101) G21C 13/02 (20130101) G21C 17/10 (20130101) G21C 19/02 (20130101) G21C 19/07 (20130101) G21C 19/18 (20130101) Original (OR) Class G21C 19/20 (20130101) G21C 19/32 (20130101)
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20220108889 — METHODS FOR DEPOSITING III-ALLOYS ON SUBSTRATES AND COMPOSITIONS THEREFROM

US 20220108889	Warren et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) National Renewable Energy Laboratory (NREL) Federally Funded Research and Development Center (FFRDC) Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S)	United States Department of Energy (Washington, District of Columbia); COLORADO SCHOOL OF MINES (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S)	Emily Lowell Warren (Golden, Colorado); Jeramy David Zimmerman (Golden, Colorado); Olivia Dean Schneble (Golden, Colorado)
ABSTRACT	A method for depositing III-V alloys on substrates and compositions therefrom. A first layer comprises a Group III element. A second layer comprises a silica. A substrate has a surface. The second layer is deposited onto a first layer. The depositing is performed by a sol-gel method. The second layer is exposed to a precursor that comprises a Group V element. At least one of the precursor or the Group V element diffuse through the silica. The first layer is transformed into a solid layer comprising a III-V alloy, wherein at least a portion of the first layer to a liquid. The silica retains the liquified first layer, enabling at least one of the precursor or the Group V element to diffuse into the liquid, resulting in the forming of the III-V alloy.
FILED	Thursday, October 07, 2021
APPL NO	17/495913
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0243 (20130101) H01L 21/02164 (20130101) H01L 21/02208 (20130101) H01L 21/02211 (20130101) H01L 21/02282 (20130101) H01L 21/02381 (20130101) H01L 21/02392 (20130101) H01L 21/02433 (20130101) H01L 21/02543 (20130101) H01L 21/02546 (20130101) H01L 21/02634 (20130101) H01L 21/02653 (20130101) Original (OR) Class
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20220109154 — SOLID-STATE LITHIUM-ION CONDUCTOR AND METHODS OF MANUFACTURE THEREOF

US 20220109154	Jun et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); Lawrence Berkeley National Laboratory (Berkeley, California)
INVENTOR(S)	KyuJung Jun (Albany, California); Gerbrand Ceder (Orinda, California); Yingzhi Sun (Albany, California); Yan Wang (Brookline, Massachusetts); Lincoln Miara (Lincoln, Massachusetts); Yan Zeng (Albany, California); Yihan Xiao (Berkeley, California)
ABSTRACT	A solid-state ion conductor including a compound of Formula 1: Li_1+(4-a)yA^a_yM_1-yXO₅ Formula 1 wherein, in Formula 1, A is an element of Groups 1 to 3 or 11 to 13, or a combination thereof, wherein an oxidation state a of A is 1≤a≤3, M is an element having an oxidation state of +4 of Groups 4 or 14, or a combination thereof, X is an element having an oxidation state of +5 of Groups 5, 15, 17, or a combination thereof, and 0<y≤1.
FILED	Monday, May 17, 2021
APPL NO	17/322325
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/58 (20130101) Original (OR) Class H01M 4/382 (20130101) H01M 4/0407 (20130101) H01M 4/662 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101)
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20220109156 — SOLID-STATE LITHIUM-ION CONDUCTOR AND METHODS OF MANUFACTURE THEREOF

US 20220109156	Xiao et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) Lawrence Berkeley National Laboratory (LBNL) Federally Funded Research and Development Center (FFRDC) Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S)	SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)	SAMSUNG ELECTRONICS CO., LTD. (Suwon-si, South Korea); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); Lawrence Berkeley National Laboratory (Berkeley, California)
INVENTOR(S)	Yihan Xiao (Berkeley, California); Gerbrand Ceder (Orinda, California); KyuJung Jun (Albany, California); Yingzhi Sun (Albany, California); Yan Wang (Brookline, Massachusetts); Lincoln Miara (Lincoln, Massachusetts); Yan Zeng (Albany, California)
ABSTRACT	A solid-state ion conductor including a compound of Formula 1: Li_{4−x−a−(b+2)y}A_xM^a(SeO₃)_2−yX^b_y Formula 1 wherein, in Formula 1, A is an element of Groups 1 or 11, or a combination thereof, M is an element of Groups 2 to 17, or a combination thereof, wherein an oxidation state a of M is 2≤a≤7, X is a cluster anion having an oxidation state of b, wherein −3≤b≤−1, 0<(4−x−a−(b+2)y)≤2, x≥0, and 0≤y≤2.
FILED	Tuesday, May 18, 2021
APPL NO	17/323074
CURRENT CPC	Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/5825 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/028 (20130101)
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20220109379 — SOFT-SWITCHING VOLTAGE-EDGE-RATE-LIMITING POWER INVERTER

US 20220109379	Wasynczuk et al.
FUNDED BY	Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S)	Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)	Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S)	Oleg Wasynczuk (West Lafayette, Indiana); Minyu Cai (Roseville, Minnesota)
ABSTRACT	An auxiliary resonant soft-edge pole inverter circuit is provided. The power inverter circuitry may include a first pair of capacitors in parallel with a corresponding pair of main power switching modules, each power switching module comprising a switch and a diode in parallel and sharing a common central node with the first pair of capacitors. The power inverter circuit may further include a first pair of auxiliary switches connected in series with a first pair of inductors, respectively, to generate resonant current from a DC power source, the first pair of inductors also sharing the common central node. The power inverter circuitry may further include a second pair of auxiliary switches connected in series with a second pair of capacitors, respectively, the second pair of auxiliary switches also sharing the common central node, the circuit producing an alternating current output at the common central node.
FILED	Tuesday, December 14, 2021
APPL NO	17/551071
CURRENT CPC	Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/4811 (20210501) Original (OR) Class H02M 7/4815 (20210501) H02M 7/5387 (20130101)
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Department of Defense (DOD)

20220105069 — METHODS FOR TREATING BRAIN METASTASIS

US 20220105069	Massague et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Army Medical Research Acquisition Activity (USAMRAA) Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI)
APPLICANT(S)	MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
ASSIGNEE(S)	MEMORIAL SLOAN-KETTERING CANCER CENTER (New York, New York)
INVENTOR(S)	Joan Massague (New York, New York); Adrienne Boire (New York, New York); Qing Chen (Palisades Park, New Jersey)
ABSTRACT	The present invention relates to methods for treating brain metastasis by inhibiting gap junction functionality. It is based, at least in part, on the discovery that cancer cells expressing Protocadherin 7 and Connexin 43 form gap junctions with astrocytes that promote the growth of brain metastases, and that inhibition of Protocadherin 7 and/or Connexin 43 expression in cancer cells reduce progression of brain metastases. It is further based on the discovery that treatment with gap junction inhibitors tonabersat and meclofenamate inhibited progression of brain metastatic lesions and enhanced the anti-cancer activity of the conventional chemotherapeutic agent, carboplatin.
FILED	Friday, June 11, 2021
APPL NO	17/345572
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/196 (20130101) A61K 31/282 (20130101) A61K 31/352 (20130101) Original (OR) Class A61K 31/555 (20130101) A61K 31/7105 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 2333/705 (20130101)
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20220105186 — Compositions Containing Nucleosides and Manganese and Their Uses

US 20220105186	Daly et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF) Department of Energy (DOE) Office of Science (DOE-SC) Environmental Remediation Sciences Program (ERSP) Department of Health and Human Services (HHS)
APPLICANT(S)	The Henry M. Jackson Foundation for the Advancement of Military Medice, Inc. (Besthesda, Maryland); The Government of the USA as Represented by the Secretary Department of Health and Human Services (Rockville, Maryland)
ASSIGNEE(S)	The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland); The Government of the USA as Represented by the Secretary Department of Health and Human Services (Rockville, Maryland)
INVENTOR(S)	Michael J. Daly (Washington, District of Columbia); Elena K. Gaidamakova (Gaithersburg, Maryland); Vera Y. Matrosova (Rockville, Maryland); Rodney L. Levine (Rockville, Maryland); Nancy B. Wehr (Bethesda, Maryland)
ABSTRACT	This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.
FILED	Tuesday, November 02, 2021
APPL NO	17/517148
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 8/24 (20130101) A61K 8/44 (20130101) A61K 8/99 (20130101) A61K 8/606 (20130101) A61K 31/7072 (20130101) A61K 31/7076 (20130101) A61K 33/32 (20130101) A61K 35/74 (20130101) A61K 45/06 (20130101) Original (OR) Class Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101)
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20220105241 — FLUORAPATITE COATED IMPLANTS AND RELATED METHODS REGARDING FEDERALLY SPONSORED RESEARCH

US 20220105241	Jeyapalina et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S)
INVENTOR(S)	Sujeevini Jeyapalina (Salt Lake City, Utah); James Beck (Salt Lake City, Utah); Kent Bachus (Salt Lake City, Utah); John Colombo (Salt Lake City, Utah); Brian Bennett (Salt Lake City, Utah); Kongnara Papangkorn (Salt Lake City, Utah)
ABSTRACT	Embodiments disclosed herein relates articles at least partially coated with fluorapatites to reduce downgrowth as well as methods of making and using the same.
FILED	Thursday, January 09, 2020
APPL NO	17/420579
CURRENT CPC	Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/06 (20130101) A61L 27/32 (20130101) Original (OR) Class A61L 27/54 (20130101) A61L 27/56 (20130101) A61L 2420/02 (20130101) A61L 2430/38 (20130101)
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20220105554 — Stamping Device for Sheet-Metal Ammunition Tray

US 20220105554	Williamson et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Seth Leland Williamson (King George, Virginia); Branden K. Hartman (Manassas, Virginia)
ASSIGNEE(S)	United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Seth Leland Williamson (King George, Virginia); Branden K. Hartman (Manassas, Virginia)
ABSTRACT	A stamping apparatus is provided for producing an ammunition tray from metal sheet template with interleaving parallel cutouts in conjunction with a shop press. The apparatus includes upper and lower tray dies, upper and lower binders, and a pair of bolsters. Each die has opposite external and internal sides. The external side has a depression pocket. The internal side has a die impression to shape the template. Each binder has a cavity. The tray dies are disposed between the binders. The bolsters are disposed for engaging the shop press to apply compressive force. Each bolster correspondingly inserts through the cavity and into the depression pocket. The template is disposed between lower and upper internal sides of respective the dies. The shop press applies compression to the bolsters for stamping the template by the dies into the ammunition tray.
FILED	Wednesday, October 07, 2020
APPL NO	17/064868
CURRENT CPC	Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 28/14 (20130101) Original (OR) Class B21D 35/001 (20130101) B21D 53/00 (20130101)
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20220105570 — Pulse Transfer for Large Area Metal Fusion System

US 20220105570	Hazlewood et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Non-Profit Organization (NPO) National Center for Manufacturing Sciences Inc. (NCMS)
APPLICANT(S)	3D Systems, Inc. (Rock Hill, South Carolina)
ASSIGNEE(S)
INVENTOR(S)	Bryon Robert Hazlewood (San Diego, California); Jose Julio Doval (Escondido, California); Evan C. Freiburg (San Diego, California)
ABSTRACT	A 3D printing system includes a print engine, a powder dispenser, and a controller. The print engine includes a chassis defining an inner chamber with a docking chamber, a build box with a build plate, an energy beam system, and a powder track coater (PTC) coupled to a gantry. The controller is configured to: (A) operate the gantry and the PTC to selectively dispense a track of powder over the build plate, (B) operate the gantry to transport the PTC to the docking station, (C) operate the energy beam system to selectively fuse the track of powder, and (D) concurrent with operating the energy beam to (D1) measure a level of powder in the PTC and (D2) if the level of powder in the PTC is below a predetermined threshold, operate the powder dispenser to transfer a controlled volume of powder to the PTC.
FILED	Tuesday, September 28, 2021
APPL NO	17/487270
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/85 (20210101) B22F 12/57 (20210101) Original (OR) Class B22F 12/70 (20210101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/123 (20130101) B23K 26/342 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 50/02 (20141201)
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20220105571 — Three-Dimensional Print Engine with Large Area Build Plane Having Optimized Gas Flow Director Structures

US 20220105571	Doval
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Non-Profit Organization (NPO) National Center for Manufacturing Sciences Inc. (NCMS)
APPLICANT(S)	3D Systems, Inc. (Rock Hill, South Carolina)
ASSIGNEE(S)
INVENTOR(S)	Jose Julio Doval (Escondido, California)
ABSTRACT	A three-dimensional (3D) print engine includes (A) a plurality of walls laterally defining a build chamber, (B) a build box including a build plate, (C) a powder dispenser, (D) a beam system for fusing layers of powder, (E) a peripheral plate disposed between the build plate and the plurality of walls and having an upper surface, (F) a gas inlet that ejects a gas flow stream that passes over the build plate and the peripheral plate, (G) a gas outlet that receives the gas flow stream, (H) a plurality of projecting structures mounted to and extending above the upper surface of the peripheral plate, and (I) a gas handling system coupled to the gas inlet and gas outlet. The plurality of projecting structures shape the flow field of the gas flow stream to provide a more uniform velocity of gas flow velocities above the build plane.
FILED	Tuesday, September 28, 2021
APPL NO	17/487211
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 12/38 (20210101) B22F 12/70 (20210101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/16 (20130101) B23K 26/083 (20130101) B23K 26/342 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201)
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20220105695 — ASSEMBLY OF FLEXIBLE OPTICAL WAVEGUIDES AND PHOTONIC CHIPS FOR OPTICAL INTERCONNECTION PACKAGING

US 20220105695	JIANG et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF)
APPLICANT(S)	Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S)	Linan JIANG (Tucson, Arizona); STANLEY K. H. PAU (Tucson, Arizona); Robert A. NORWOOD (Tucson, Arizona); Thomas L. KOCH (Tucson, Arizona)
ABSTRACT	A method of forming an optical interconnect between first and second photonic chips located on an optical printed circuit board (OPCB) includes applying a coupling agent to a bonding surface of a flexible, freestanding polymer waveguide array film having at least one polymer waveguide disposed therein. The waveguide array film is placed onto the first and second photonic chips so that the waveguide array film extends over a gap and/or a step between the first and second photonic chips to thereby form a bonding interface between the bonding surface of the waveguide array film and the first and second photonic chips. The coupling agent is selected such that optical coupling between the first and second photonic chips arises simultaneously with formation of the bonding interface.
FILED	Friday, January 17, 2020
APPL NO	17/423893
CURRENT CPC	Producing Particular Articles From Plastics or From Substances in a Plastic State B29D 11/0075 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 6/4239 (20130101)
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20220106622 — METHOD FOR PATHOGEN IDENTIFICATION

US 20220106622	Rininsland et al.
FUNDED BY	Department of Defense (DOD) Defense Logistics Agency (DLA)
APPLICANT(S)	Mesa Photonics, LLC (Santa Fe, New Mexico)
ASSIGNEE(S)	Mesa Photonics, LLC (Santa Fe, New Mexico)
INVENTOR(S)	Frauke Henrike Rininsland (Santa Fe, New Mexico); Daniel James Kane (Santa Fe, New Mexico)
ABSTRACT	The present invention relates to a method for detecting a pathogen in cellular lysate by measuring pathogen-specific enzyme activity. The method comprises contacting the cellular lysate with a substrate the pathogen of interest recognizes and modifies, and obtaining a measurable, recordable, signal. The method may comprise detection of SARS-CoV viruses using the activity of SARS PLpro enzyme in tongue scrape lysate as a readout.
FILED	Tuesday, July 20, 2021
APPL NO	17/380862
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/165 (20130101) G01N 2333/9513 (20130101)
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20220106964 — TANDEM BLADE ROTOR DISK

US 20220106964	DITOMASSO et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Research Laboratory (AFRL)
APPLICANT(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
ASSIGNEE(S)	RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut)
INVENTOR(S)	JOHN C. DITOMASSO (Glastonbury, Connecticut); MATTHEW P. FORCIER (South Windsor, Connecticut)
ABSTRACT	A tandem rotor disk apparatus may include a rotor disk body concentric about an axis. The tandem rotor disk apparatus may also include a first blade extending radially outward of the rotor disk body and a second blade extending radially outward of the rotor disk body. The first blade may be offset from the second blade in a direction parallel to the axis. The tandem rotor disk apparatus may be implemented in a gas turbine engine with no intervening stator vane stages disposed between the first blade and the second blade. The tandem rotor disk apparatus may include two separate rotor disk bodies.
FILED	Friday, September 10, 2021
APPL NO	17/472236
CURRENT CPC	Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/34 (20130101) F01D 5/142 (20130101) F01D 5/146 (20130101) F01D 5/3007 (20130101) F01D 5/3038 (20130101) Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 3/04 (20130101) Non-positive-displacement Pumps F04D 19/02 (20130101) F04D 29/321 (20130101) F04D 29/322 (20130101) F04D 29/324 (20130101) Original (OR) Class F04D 29/644 (20130101)
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20220107160 — Glide Trajectory Optimization for Aerospace Vehicles

US 20220107160	Cerasuolo
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON)
APPLICANT(S)	Ed Frank Cerasuolo (Sterling, Virginia)
ASSIGNEE(S)	United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Ed Frank Cerasuolo (Sterling, Virginia)
ABSTRACT	A computer implemented method is provided for in-flight trajectory steering a vehicle by an optimal path to either a preplanned or in-flight commanded destination. The method includes incorporating realistic environmental physical constants; setting initial angle of attack (AoA) and initial AoA rate; incrementing flight AoA; measuring operation parameters; establishing a flight trajectory; calculating an optimal trajectory; comparing flight trajectories; and commanding flight control. The plurality of physical constants include for gravity and atmospheric conditions, the latter typically provided in tabular form, the flight AoA increments from the initial AoA and any prior increments. The plurality of operation parameters of the vehicle includes pressure, velocity and flight path angle. The flight trajectory denotes the path of the vehicle to its destination based on the operation parameters using the physical constants. The optimal trajectory is based on with altitude (based on physical constants) and velocity (based on measured operation parameters) of the vehicle. The flight trajectory is compared to the optimal trajectory as a steering correction by altering the flight AoA. The vehicle's flight control involves executing the steering correction at the flight AoA.
FILED	Friday, October 02, 2020
APPL NO	17/061787
CURRENT CPC	Weapon Sights; Aiming F41G 7/306 (20130101) Original (OR) Class F41G 7/346 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/12 (20130101) G05D 1/0094 (20130101) G05D 1/107 (20130101) Electric Digital Data Processing G06F 17/17 (20130101)
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20220107322 — LIPID, PROTEIN, AND METABOLITE MARKERS FOR THE DIAGNOSIS AND TREATMENT OF PROSTATE CANCER

US 20220107322	Kiebish et al.
FUNDED BY	Department of Defense (DOD) Uniformed Services University of the Health Sciences (USUHS) Henry M Jackson Foundation for the Advancement of Military Medicine, Inc (HJF)
APPLICANT(S)	Berg LLC (Framingham, Massachusetts); The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S)	Michael Andrew Kiebish (Millis, Massachusetts); Niven Rajin Narain (Cambridge, Massachusetts); Rangaprasad Sarangarajan (Boylston, Massachusetts); Viatcheslav R. Akmaev (Sudbury, Massachusetts); Leonardo Rodrigues (Ashland, Massachusetts); Yezhou Sun (Framingham, Massachusetts); Shiv Srivastava (Potomac, Maryland); Albert Dobi (Rockville, Maryland)
ABSTRACT	Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of prostate cancer. The invention also provides methods of treating prostate cancer by administering a biomarker or an agent that modulates a biomarker of prostate cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.
FILED	Wednesday, June 09, 2021
APPL NO	17/343538
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 31/00 (20130101) Acyclic or Carbocyclic Compounds C07C 229/12 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57434 (20130101) Original (OR) Class G01N 2021/3155 (20130101) G01N 2030/027 (20130101) G01N 2500/10 (20130101) G01N 2800/60 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/46 (20130101)
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20220107401 — Distributed Clock System for the Synchronization of Instrumentation

US 20220107401	Landry et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Naval Research Laboratory (NRL)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
INVENTOR(S)	Blake J. Landry (Saint Martinville, Louisiana); Charles R. Key (Diamondhead, Mississippi)
ABSTRACT	A method for a distributed clock system (DCS) device that includes receiving a GPS signal, determining that a first current time equals a predetermined start time, and generating a shifted GPS signal by applying a configurable delay to the received GPS signal, the shifted GPS signal alternating between a low value and a high value. The method includes responsive to a falling edge of the shifted GPS signal, generating an ARM signal having a rising edge after a falling edge of the shifted GPS signal, and responsive to the ARM signal being high and the shifted GPS signal being high, generating an output enable signal. The method includes transmitting, while the output enable signal is high, a triggering signal, the triggering signal having one or more synchronizing pulses that cause one or more sampling devices to sample data according to the frequency associated with the raw clock signal.
FILED	Friday, October 01, 2021
APPL NO	17/491902
CURRENT CPC	Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 11/08 (20130101) Original (OR) Class G01S 19/24 (20130101)
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20220107465 — WORMHOLE BACKPLANE ULTRAHIGH DENSITY OPTICAL ROUTING SYSTEM

US 20220107465	JENSEN et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Intel Corporation (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S)	Ralph JENSEN (Hillsboro, Oregon); Michael T. CROCKER (Portland, Oregon); Aaron GORIUS (Upton, Massachusetts); Kevin P. MA (Beaverton, Oregon)
ABSTRACT	Apparatus and methods employing wormhole structures supporting ultra-high density optical routing systems. Microstructures comprising wormhole tunnels are formed in optical looms with wormhole openings arranged in patterns, such as a high-density XY grid. Optical fibers are inserted into respective wormhole tunnels, and sleeves are used to precisely align fiber ends. A rack loom comprising a wormhole backplane is fabricated in a similar manner, with wormhole openings arrayed in the same patterns. The sleeves comprise plug-receptacle sleeve pairs, where when an optical loom (or connector bar of the optical loom) face urged toward the front face of the rack loom, the plug and receptacle sleeves are mated, resulting in precise alignment of the optical fiber ends in the pairs of sleeves. Palpebral structures may also be fabricated to provide a self-cleaning function with optional lubrication. The solutions provide more than an order of magnitude improvement over current fiber connector densities, while substantially reducing costs.
FILED	Thursday, December 16, 2021
APPL NO	17/553053
CURRENT CPC	Optical Elements, Systems, or Apparatus G02B 6/38 (20130101) Original (OR) Class Multiplex Communication H04J 14/0267 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 49/251 (20130101)
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20220107488 — SYSTEMS AND METHODS FOR LASER SCISSORS AND TWEEZERS WITH A QUANTITATIVE PHASE MICROSCOPE (QPM)

US 20220107488	BERNS et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Michael W. BERNS (Irvine, California); Nicole WAKIDA (Irvine, California); Daryl PREECE (Irvine, California); Toyohiko YAMAUCHI (Irvine, California); Pegah POULADIAN (Irvine, California)
ABSTRACT	Systems and methods are provided for Quantitative Phase Microscopes (QPM) having laser systems including one or more of laser scissors and laser tweezers. In one embodiment, the system includes one or more structural elements, such as a stage and dichroic plate for operation of a QPM with laser scissors/tweezers. Another embodiment is directed to a method of operating a QPM system having laser scissors/tweezers. One or more solutions are provided for biodmedical applications of a QPM system including simulation and analysis of trauma on cellular structures and organelles. Processes are also provided for simulation and analysis of traumatic injury, including imaging and analysis of astrocytes.
FILED	Tuesday, September 07, 2021
APPL NO	17/468223
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6402 (20130101) G01N 21/6458 (20130101) G01N 33/4833 (20130101) Optical Elements, Systems, or Apparatus G02B 21/32 (20130101) Original (OR) Class
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20220107911 — APPARATUSES, METHODS, AND SYSTEMS FOR OPERATIONS IN A CONFIGURABLE SPATIAL ACCELERATOR

US 20220107911	FLEMING et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	Intel Corporation (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S)	Kermin E. FLEMING (Hudson, Massachusetts); Simon C. STEELY (Hudson, New Hampshire); Kent D. GLOSSOP (Nashua, New Hampshire); Mitchell DIAMOND (Shrewsbury, Massachusetts); Benjamin KEEN (Marlborough, Massachusetts); Dennis BRADFORD (Portland, Oregon); Fabrizio Petrini (Menlo Park, California); Barry TANNENBAUM (Nashua, New Hampshire); Yongzhi ZHANG (Wayland, Massachusetts)
ABSTRACT	Systems, methods, and apparatuses relating to operations in a configurable spatial accelerator are described. In one embodiment, a configurable spatial accelerator includes a first processing element that includes a configuration register within the first processing element to store a configuration value that causes the first processing element to perform an operation according to the configuration value, a plurality of input queues, an input controller to control enqueue and dequeue of values into the plurality of input queues according to the configuration value, a plurality of output queues, and an output controller to control enqueue and dequeue of values into the plurality of output queues according to the configuration value.
FILED	Tuesday, December 14, 2021
APPL NO	17/550875
CURRENT CPC	Electric Digital Data Processing G06F 9/30145 (20130101) G06F 13/4027 (20130101) Original (OR) Class G06F 15/7867 (20130101)
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20220108132 — METHOD AND SYSTEM FOR AN ADVERSARIAL TRAINING USING META-LEARNED INITIALIZATION

US 20220108132	ZHANG et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Robert Bosch GmbH (Stuttgart, Germany)
ASSIGNEE(S)
INVENTOR(S)	Xiao ZHANG (Charlottesville, Virginia); Anit Kumar SAHU (Pittsburgh, Pennsylvania); Jeremy KOLTER (Pittsburgh, Pennsylvania)
ABSTRACT	A computer-program product storing instructions which, when executed by a computer, cause the computer to receive an input data from a sensor, wherein the input data includes data indicative of an image, wherein the sensor includes a video, radar, LiDAR, sound, sonar, ultrasonic, motion, or thermal imaging sensor, generate an adversarial version of the input data, utilizing a generator, in response to the input data, create a training data set utilizing the input data and the adversarial version of the input data, determine an update direction of a meta model utilizing stochastic gradient respect with respect to an adversarial loss, and determine a cross-entropy based classification loss in response to the input data and classification utilizing a classifier, and update the meta model and the classifier in response to the cross-entropy classification loss utilizing the training data set.
FILED	Friday, October 02, 2020
APPL NO	17/062385
CURRENT CPC	Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6257 (20130101) Original (OR) Class G06K 9/6264 (20130101) Computer Systems Based on Specific Computational Models G06N 3/02 (20130101) G06N 20/00 (20190101)
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20220108151 — PHYSICS AUGMENTED NEURAL NETWORKS CONFIGURED FOR OPERATING IN ENVIRONMENTS THAT MIX ORDER AND CHAOS

US 20220108151	Ditto et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	North Carolina State University (Raleigh, North Carolina)
ASSIGNEE(S)
INVENTOR(S)	William Lawrence Ditto (Wake Forest, North Carolina); John Florian Lindner (Wooster, Ohio); Sudeshna Sinha (Punjab, India); Scott Thomas Miller (Brooklyn, New York); Anshul Choudhary (Raleigh, North Carolina); Elliott Gregory Holliday (Durham, North Carolina)
ABSTRACT	Methods, systems, and computer readable media for utilizing an augmented neural network are disclosed. In one embodiment, the method includes utilizing a neural network (NN) pre-processor to convert generic coordinates associated with a dynamical system to canonical coordinates, concatenating a Hamiltonian neural network (HNN) to the NN pre-processor to create a generalized HNN, and training the generalized HNN to learn nonlinear dynamics present in the dynamical system from generic training data. The method also includes utilizing the trained generalized HNN to forecast the nonlinear dynamics, and quantifying chaotic behavior from the forecasted nonlinear dynamics to discover and map one or more transitions between orderly states and chaotic states exhibited by the dynamical system.
FILED	Friday, October 01, 2021
APPL NO	17/492172
CURRENT CPC	Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) G06N 3/0418 (20130101) Original (OR) Class G06N 3/0454 (20130101)
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20220108430 — HYPERSPECTRAL IMAGING SYSTEM

US 20220108430	SHI et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Congressionally Directed Medical Research Programs (CDMRP)
APPLICANT(S)	UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California)
ASSIGNEE(S)
INVENTOR(S)	Wen SHI (Los Angeles, California); Eun Sang KOO (Los Angeles, California); Scott E. FRASER (Los Angeles, California); Francesco CUTRALE (Los Angeles, California)
ABSTRACT	This invention relates to a hyperspectral imaging system for denoising and/or color unmixing multiple overlapping spectra in a low signal-to-noise regime with a fast analysis time. This system may carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze hyper-spectral time-lapse data. For example, this system may carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze five-dimensional (5D) hyper-spectral time-lapse data. Advantages of this imaging system may include: (a) fast computational speed, (b) the ease of phasor analysis, and (c) a denoising algorithm to obtain the minimally-acceptable signal-to-noise ratio (SNR). An unmixed color image of a target may be generated. These images may be used in diagnosis of a health condition, which may enhance a patient's clinical outcome and evolution of the patient's health.
FILED	Friday, January 31, 2020
APPL NO	17/427890
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/0075 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/2823 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/10 (20130101) Original (OR) Class G06T 2207/10024 (20130101) G06T 2207/20056 (20130101)
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20220108455 — RGBD VIDEO SEMANTIC SEGMENTATION WITH TEMPORAL AND GEOMETRIC CONSISTENCY

US 20220108455	CHIU et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) U.S. Army Corps of Engineers (USACE) Engineer Research and Development Center (ERDC) Geospatial Research Laboratory (GRL)
APPLICANT(S)	SRI International (Menlo Park, California)
ASSIGNEE(S)
INVENTOR(S)	Han-Pang CHIU (West Windsor, New Jersey); Junjiao TIAN (Atlanta, Georgia); Zachary SEYMOUR (Pennington, New Jersey); Niluthpol C. MITHUN (Lawrenceville, New Jersey); Alex KRASNER (Princeton, New Jersey); Mikhail SIZINTSEV (Princeton, New Jersey); Abhinav RAJVANSHI (Plainsboro, New Jersey); Kevin KAIGHN (Medord, New Jersey); Philip MILLER (Yardley, New Jersey); Ryan VILLAMIL (Plainsboro, New Jersey); Supun SAMARASEKERA (Skillman, New Jersey)
ABSTRACT	A method, machine readable medium and system for RGBD semantic segmentation of video data includes determining semantic segmentation data and depth segmentation data for less than all classes for images of each frame of a first video, determining semantic segmentation data and depth segmentation data for images of each key frame of a second video including a synchronous combination of respective frames of the RGB video and the depth-aware video in parallel to the determination of the semantic segmentation data and the depth segmentation data for each frame of the first video, temporally and geometrically aligning respective frames of the first video and the second video, and predicting semantic segmentation data and depth segmentation data for images of a subsequent frame of the first video based on the determination of the semantic segmentation data and depth segmentation data for images of a key frame of the second video.
FILED	Thursday, October 07, 2021
APPL NO	17/496403
CURRENT CPC	Image Data Processing or Generation, in General G06T 3/40 (20130101) G06T 7/38 (20170101) G06T 7/50 (20170101) G06T 7/174 (20170101) Original (OR) Class G06T 2207/10016 (20130101) G06T 2207/10024 (20130101) G06T 2207/20112 (20130101)
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20220108733 — Memory Circuits And Methods With Write Assist

US 20220108733	Lowe et al.
FUNDED BY	Department of Defense (DOD) Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S)	Intel Corporation (Santa Clara, California)
ASSIGNEE(S)	Intel Corporation (Santa Clara, California)
INVENTOR(S)	Wayson Lowe (Redwood City, California); Ban Wong (Milpitas, California)
ABSTRACT	A memory circuit includes a column of memory cells. A column selection circuit is coupled to the column of the memory cells through a bit line. The column selection circuit pulls a voltage of the bit line toward a predefined voltage in response to a write control signal during a write operation to at least one of the memory cells in the column of the memory cells. A write enable circuit generates a write enable signal. A regenerative repeater circuit is coupled to the column of the memory cells through the bit line. The regenerative repeater circuit pulls the voltage of the bit line toward the predefined voltage in response to the write enable signal during the write operation.
FILED	Thursday, December 16, 2021
APPL NO	17/553439
CURRENT CPC	Static Stores G11C 7/12 (20130101) G11C 7/22 (20130101) G11C 7/1096 (20130101) Original (OR) Class G11C 8/10 (20130101) G11C 11/419 (20130101)
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20220108847 — CONVERSION OF HALIDE PEROVSKITE SURFACES TO INSOLUBLE, WIDE-BANDGAP LEAD OXYSALTS FOR ENHANCED SOLAR CELL STABILITY

US 20220108847	Huang et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Nutech Ventures (Lincoln, Nebraska); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S)	Jinsong Huang (Chapel Hill, North Carolina); Shuang Yang (Lincoln, Nebraska)
ABSTRACT	Electronic devices comprising a first layer, said first layer comprising a perovskite material; and a coating layer disposed on a surface of said first layer; wherein said coating layer comprises a coating oxysalt. Also provided herein are perovskite materials comprising: a coating layer on at least a portion of a surface of said perovskite material; wherein said coating layer comprises a coating oxysalt. Further provided herein are methods for forming a coating layer on a surface of a perovskite material comprising steps of: exposing said surface to a fluid having a precursor oxysalt dissolved therein such that said coating layer forms on said surface via a chemical reaction between said perovskite material and said precursor oxysalt; wherein said coating layer comprises a coating oxysalt.
FILED	Friday, January 24, 2020
APPL NO	17/426916
CURRENT CPC	Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/24 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2027 (20130101) Original (OR) Class H01G 9/2059 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0077 (20130101) H01L 51/422 (20130101)
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20220108848 — RECONFIGURABLE MICROWAVE METADEVICES

US 20220108848	Omenetto et al.
FUNDED BY	Department of Defense (DOD) Department of the Navy (DON) Office of Naval Research (ONR)
APPLICANT(S)	Trustees of Tufts College (Medford, Massachusetts)
ASSIGNEE(S)
INVENTOR(S)	Fiorenzo G. Omenetto (Lexington, Massachusetts); Giorgio E. Bonacchini (Palo Alto, California)
ABSTRACT	Embodiments of the present disclosure provide a metadevice including a substrate, a resonator loop coupled to the substrate. The resonator loop having a first gap in the resonator loop. The metadevice includes an organic electrochemical transistor positioned in the first gap, a gate electrode, and an electrolyte extending between the organic electrochemical transistor and the gate electrode.
FILED	Monday, October 04, 2021
APPL NO	17/449935
CURRENT CPC	Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/28 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/283 (20130101)
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20220109051 — SUPERLATTICE STRUCTURE INCLUDING TWO-DIMENSIONAL MATERIAL AND DEVICE INCLUDING THE SUPERLATTICE STRUCTURE

US 20220109051	LEE et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Samsung Electronics Co., Ltd. (Suwon-si, South Korea); THE UNIVERSITY OF CHICAGO (Chicago, Illinois); Center for Technology Licensing at Cornell University (Ithaca, New York)
ASSIGNEE(S)	Samsung Electronics Co., Ltd. (Suwon-si, South Korea); THE UNIVERSITY OF CHICAGO (Chicago, Illinois); Center for Technology Licensing at Cornell University (Ithaca, New York)
INVENTOR(S)	Minhyun LEE (Suwon-si, South Korea); Jiwoong PARK (Chicago, Illinois); Saien XIE (Ithaca, New York); Jinseong HEO (Seoul, South Korea); Hyeonjin SHIN (Suwon-si, South Korea)
ABSTRACT	Provided are a superlattice structure including a two-dimensional material and a device including the superlattice structure. The superlattice structure may include at least two different two-dimensional (2D) materials bonded to each other in a lateral direction, and an interfacial region of the at least two 2D materials may be strained. The superlattice structure may have a bandgap adjusted by the interfacial region that is strained. The at least two 2D materials may include first and second 2D materials. The first 2D material may have a first bandgap in an intrinsic state thereof. The second 2D material may have a second bandgap in an intrinsic state thereof. An interfacial region of the first and second 2D materials and an adjacent region may have a third bandgap between the first bandgap and the second bandgap.
FILED	Monday, November 01, 2021
APPL NO	17/515713
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/158 (20130101) Original (OR) Class H01L 29/1054 (20130101)
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20220109283 — Cooling of a Laser Set

US 20220109283	DuBois et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA)
APPLICANT(S)	The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S)	Terry DuBois (Forest Hill, Maryland); Jaclyn Lynch (Baltimore, Maryland); Eric Conrad (Baltimore, Maryland)
ABSTRACT	Various embodiments that pertain to cooling of a laser set are described. In one example, the lasers can be a set of laser diodes. A laser diode cooling system can create a vacuum environment that causes a coolant to be below atmospheric pressure. The coolant can be water supplied by an exchangeable tank. When the tank is empty, the tank can be replaced with a new tank.
FILED	Tuesday, October 05, 2021
APPL NO	17/493876
CURRENT CPC	Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/02423 (20130101) Original (OR) Class H01S 5/02438 (20130101)
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National Science Foundation (NSF)

20220104989 — METHOD, APPARATUS, AND SYSTEM FOR TELEOPERATED, MOTORIZED REHABILITATIVE CYCLING

US 20220104989	DIXON et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S)	UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesvile, Florida)
ASSIGNEE(S)
INVENTOR(S)	Warren E. DIXON (Gainesville, Florida); Kimberly J. STUBBS (Middleburg, Florida); Brendon ALLEN (Gainesville, Florida)
ABSTRACT	Provided herein is a method, apparatus, and system for teleoperated, functional electric stimulation actuated rehabilitative cycling. Methods may include: receiving, at a master system, rotational input generating master system sensor input having a master system cadence; providing the master system sensor input including the master system cadence to a controller based on the rotational input from a rehabilitation participant or a remote therapist received at the master system; receiving, at a slave system, rotational input from the rehabilitation participant generating slave sensor input having a slave system cadence; providing the slave system sensor input including the slave system cadence to the controller based on the rotational input from the participant received at the slave system; and providing, from the controller, feedback through the master system in response to a difference between the master system cadence and the slave system cadence.
FILED	Tuesday, September 28, 2021
APPL NO	17/449159
CURRENT CPC	Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0214 (20130101) Original (OR) Class A61H 1/0274 (20130101) A61H 2201/10 (20130101) A61H 2201/501 (20130101) A61H 2201/1215 (20130101) A61H 2201/5064 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/36003 (20130101) A61N 1/36031 (20170801)
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20220105191 — BIOORTHOGONAL COMPOSITIONS

US 20220105191	MEJIA ONETO et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Technology Translational Impacts (TI)
APPLICANT(S)	TAMBO, INC. (San Francisco, California)
ASSIGNEE(S)
INVENTOR(S)	Jose MEJIA ONETO (San Francisco, California); Robert GALEMMO, JR. (Hong Kong, China PRC)
ABSTRACT	The present disclosure provides bioorthogonal compositions for delivering agents in a subject. The disclosure also provides methods of producing the compositions, as well as methods of using the same.
FILED	Friday, December 17, 2021
APPL NO	17/554792
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 47/18 (20130101) A61K 47/61 (20170801) Original (OR) Class A61K 47/555 (20170801) A61K 47/6903 (20170801) A61K 47/6939 (20170801) A61K 49/0032 (20130101) A61K 49/0054 (20130101) A61K 49/0073 (20130101) A61K 51/0495 (20130101) A61K 51/1213 (20130101) A61K 51/1244 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Polysaccharides; Derivatives Thereof C08B 37/0084 (20130101)
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20220105202 — UNIVERSAL MULTI-FUNCTIONAL GSH-RESPONSIVE SILICA NANOPARTICLES FOR DELIVERY OF BIOMOLECULES INTO CELLS

US 20220105202	GONG et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Biological Sciences (BIO) Division of Integrative Organismal Systems (IOS)
APPLICANT(S)	Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S)	Shaoqin GONG (Middleton, Wisconsin); Yuyuan Wang (Madison, Wisconsin)
ABSTRACT	The present technology provides a nanoparticle comprising: the polysiloxanes comprise silyloxy subunits having the structure (I) as shown herein, wherein R^aat each occurrence is independently selected from a bond to a Si of another polysiloxane chain or a C_1-12alkyl group; Rⁱat each occurrence is independently selected from the group consisting of C_1-12alkyl and C_2-12alkenyl groups, optionally substituted with a substituent selected from the group consisting of halogen and NR¹₂, wherein each occurrence of R¹is independently selected from H or a C_1-12alkyl group, or two R¹groups, together with the N atom to which they are attached, form a pyrrolidine or piperidine ring; the crosslinks between polysiloxanes comprise disulfide linkages, the nanoparticle comprises an exterior surface comprising surface-modifying groups attached to and surrounding the silica network, wherein the surface-modifying groups comprise polyethylene glycol (PEG), polysarcosine, polyzwitterion, polycation, polyanion, or combinations of two or more thereof; and the nanoparticle has an average diameter of 15 nm to 200 nm. The nanoparticles herein may include biomolecules such as polynucleic acids, proteins, and complexes thereof, e.g., Cas9 RNP.
FILED	Thursday, October 14, 2021
APPL NO	17/501635
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/5146 (20130101) A61K 47/6935 (20170801) A61K 48/0041 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 83/001 (20130101)
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20220105498 — RUTHENIUM-TRANSITION METAL ALLOY CATALYSTS

US 20220105498	WANG et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	CORNELL UNIVERSITY (Ithaca, New York)
ASSIGNEE(S)	CORNELL UNIVERSITY (Ithaca, New York)
INVENTOR(S)	Hongsen WANG (Ithaca, New York); Héctor D. ABRUÑA (Ithaca, New York)
ABSTRACT	Provided is a catalytically active particle comprising an alloy, said alloy comprising: greater than or equal to 50 atomic % ruthenium (Ru); and 1 to 50 atomic % of one or more transition metals (M) selected from cobalt (Co), nickel (Ni), and iron (Fe), wherein the sum of the atomic percentages of Ru and M is greater than 65 atomic % of the alloy, and wherein, in the particle, the alloy is not fully or partially encapsulated by a layer of platinum atoms. Devices and processes employing the catalytically active particle are also provided.
FILED	Tuesday, March 17, 2020
APPL NO	17/430613
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/18 (20130101) B01J 23/8913 (20130101) Original (OR) Class Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/04 (20130101) C25B 9/19 (20210101) C25B 11/065 (20210101) C25B 11/089 (20210101) C25B 13/00 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/9058 (20130101) H01M 4/9083 (20130101) H01M 8/1004 (20130101)
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20220105680 — MODULAR EXPANDABLE 3D PRINTER

US 20220105680	Kim et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA National Science Foundation (NSF) Office of International Science and Engineering (OISE)
APPLICANT(S)	THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, (Las Vegas, Nevada)
ASSIGNEE(S)
INVENTOR(S)	Kwang J. Kim (Henderson, Nevada); Alexandrea Washington (Las Vegas, Nevada); Emma Chao (Henderson, Nevada); Justin Neubauer (Las Vegas, Nevada); Sophia Leon (Las Vegas, Nevada); Zachary Frank (Las Vegas, Nevada); Zakai Olsen (Las Vegas, Nevada)
ABSTRACT	A modular and expandable 3D printer frame includes frame members to be coupled together to form a base defining an inner area. Each frame member includes at least one coupling member to removably couple the frame member to another of the frame members. The printer frame further includes first modular plates to be disposed within the inner area, and second modular plates to be disposed within the inner area and removably coupled to the first modular plates. The first and second modular plates, when coupled together, define a printer footprint.
FILED	Wednesday, December 04, 2019
APPL NO	17/428424
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/25 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/295 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201)
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20220106278 — REAGENTS AND METHODS FOR TETRAZINE SYNTHESIS

US 20220106278	Fox et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Research Resources (NCRR) National Institute of General Medical Sciences (NIGMS) NIH Office of the Director (NIHOD) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Chemistry (CHE)
APPLICANT(S)	University of Delaware (Newark, Delaware)
ASSIGNEE(S)	University of Delaware (Newark, Delaware)
INVENTOR(S)	Joseph M. Fox (Landenberg, Pennsylvania); William Lambert (Gurnee, Illinois); Yinzhi Fang (Newark, Delaware); Christopher William am Ende (Mystic, Connecticut); Subham Mahapatra (Groton, Connecticut); Yixin XIE (Newark, Delaware); Chuanqi Wang (Newark, Delaware)
ABSTRACT	Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.
FILED	Friday, October 01, 2021
APPL NO	17/492016
CURRENT CPC	Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/0298 (20130101) B01J 31/2265 (20130101) B01J 31/2409 (20130101) B01J 2531/824 (20130101) Heterocyclic Compounds C07D 257/08 (20130101) Original (OR) Class C07D 401/04 (20130101) C07D 401/14 (20130101) C07D 403/08 (20130101) C07D 405/04 (20130101) C07D 409/04 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 5/022 (20130101) Steroids C07J 43/003 (20130101)
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20220106535 — Lubricating Base Oils from Esterified Alkoxylated Polyols Using Saturated Long-Chain Fatty Acids

US 20220106535	Hunt et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) National Science Foundation (NSF) Directorate of Technology Translational Impacts (TI) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Tetramer Technologies, LLC (Pendleton, South Carolina)
ASSIGNEE(S)	Tetramer Technologies, LLC (Pendleton, South Carolina)
INVENTOR(S)	Zachary Hunt (Simpsonville, South Carolina); Peter Gennaro (Mount Pleasant, South Carolina); Jeffrey R. DiMaio (Pendleton, South Carolina); Benjamin Bergmann (Liberty, South Carolina)
ABSTRACT	The present disclosure relates to methods and compositions for making bio-based, biodegradable, and non-bioaccumulating lubricating base oils generated by esterifying alkoxylated polyols (average alkoxylation ≥3) with long-chain (≥C14) saturated and unsaturated fatty acids (FA) or fatty acids modified using industry recognized techniques.
FILED	Thursday, December 16, 2021
APPL NO	17/552418
CURRENT CPC	Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 101/04 (20130101) C10M 105/44 (20130101) Original (OR) Class C10M 2207/301 (20130101) C10M 2209/043 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2040/04 (20130101)
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20220107383 — SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR REAL TIME IMAGING USING A PORTABLE DEVICE

US 20220107383	Rappaport et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS) Directorate for Mathematical and Physical Sciences (MPS) Division of Astronomical Sciences (AST)
APPLICANT(S)	NEW YORK UNIVERSITY (New York, New York)
ASSIGNEE(S)
INVENTOR(S)	Theodore S. Rappaport (Raleigh, North Carolina); Ojas Kanhere (Brooklyn, New York)
ABSTRACT	Exemplary system, method and computer-accessible medium for selecting at least one location of (i) at least one receiver or transceiver or (ii) at least one transmitter or transceiver can be provided. For example, it is possible to facilitate a receipt, from the at least one transmitter or transceiver, of a plurality of signals by the receiver(s) or transceiver(s). Each of the signals has a multipath component. Then, it is possible to determine time of flight (ToF) information and angle of arrival (AoA) information of the multipath components present in the signals. Further, it is possible to determine one or more possible locations of (i) the receiver(s) or transceiver(s) or (ii) the transmitter(s) or transceiver(s) based on the ToF information, the AoA information, and a model of physical surroundings. The location(s) of (i) the receiver(s) or transceiver(s), or (ii) the transmitter(s) or transceiver(s) can be selected based on the one or more possible locations.
FILED	Wednesday, December 15, 2021
APPL NO	17/552200
CURRENT CPC	Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/00 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/00 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0221 (20130101) G01S 5/0268 (20130101) Original (OR) Class G01S 5/0294 (20130101)
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20220108786 — SYSTEM AND METHOD FOR DATA VISUALIZATION

US 20220108786	Wright et al.
FUNDED BY	National Science Foundation (NSF) Directorate of Technology Translational Impacts (TI)
APPLICANT(S)	Omics Data Automation, Inc. (Beaverton, Oregon)
ASSIGNEE(S)
INVENTOR(S)	Hollis Wright (Portland, Oregon); Ganapati Srinivasa (Portland, Oregon)
ABSTRACT	Methods and systems are provided for viewing multi-modal data in three dimensions. In one example, a method for visualizing and manipulating multi-modal features of a plurality of data objects includes accessing a plurality of datasets associated with a subject of interest, where data in the plurality of datasets changes in real-time; displaying a hub object representing the subject of interest; dynamically displaying a plurality of axis objects associated with the subject of interest, each comprising a representation of a summary metric of a respective dataset of the plurality of datasets and each displayed proximate the hub object, including adjusting a length and/or intensity of one or more of the plurality of axis objects as the data change; and in response to selection of a first axis object, displaying a first track object including a plurality of representations of data points within a first dataset of the plurality of datasets.
FILED	Friday, October 01, 2021
APPL NO	17/449764
CURRENT CPC	Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) Original (OR) Class G16H 50/20 (20180101)
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20220109051 — SUPERLATTICE STRUCTURE INCLUDING TWO-DIMENSIONAL MATERIAL AND DEVICE INCLUDING THE SUPERLATTICE STRUCTURE

US 20220109051	LEE et al.
FUNDED BY	Department of Defense (DOD) Department of the Air Force (DAF) Air Force Office of Scientific Research (AFOSR) National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (MPS) Division of Materials Research (DMR)
APPLICANT(S)	Samsung Electronics Co., Ltd. (Suwon-si, South Korea); THE UNIVERSITY OF CHICAGO (Chicago, Illinois); Center for Technology Licensing at Cornell University (Ithaca, New York)
ASSIGNEE(S)	Samsung Electronics Co., Ltd. (Suwon-si, South Korea); THE UNIVERSITY OF CHICAGO (Chicago, Illinois); Center for Technology Licensing at Cornell University (Ithaca, New York)
INVENTOR(S)	Minhyun LEE (Suwon-si, South Korea); Jiwoong PARK (Chicago, Illinois); Saien XIE (Ithaca, New York); Jinseong HEO (Seoul, South Korea); Hyeonjin SHIN (Suwon-si, South Korea)
ABSTRACT	Provided are a superlattice structure including a two-dimensional material and a device including the superlattice structure. The superlattice structure may include at least two different two-dimensional (2D) materials bonded to each other in a lateral direction, and an interfacial region of the at least two 2D materials may be strained. The superlattice structure may have a bandgap adjusted by the interfacial region that is strained. The at least two 2D materials may include first and second 2D materials. The first 2D material may have a first bandgap in an intrinsic state thereof. The second 2D material may have a second bandgap in an intrinsic state thereof. An interfacial region of the first and second 2D materials and an adjacent region may have a third bandgap between the first bandgap and the second bandgap.
FILED	Monday, November 01, 2021
APPL NO	17/515713
CURRENT CPC	Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/158 (20130101) Original (OR) Class H01L 29/1054 (20130101)
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20220109103 — MAGNETIC MEMORY DEVICE USING DOPED SEMICONDUCTOR LAYER

US 20220109103	Amiri et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S)	Pedram Khalili Amiri (Wilmette, Illinois); Manijeh Razeghi (Wilmette, Illinois)
ABSTRACT	Magnetic memory devices are provided. The devices comprise a first ferromagnetic layer, a second ferromagnetic layer, and a tunnel barrier layer composed of a doped semiconductor (instead of an insulator or a dielectric) between the first and second ferromagnetic layers and forming at least one ferromagnetic-doped semiconductor interface.
FILED	Friday, January 31, 2020
APPL NO	17/426508
CURRENT CPC	Static Stores G11C 11/161 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/222 (20130101) H01L 43/02 (20130101) H01L 43/10 (20130101) Original (OR) Class
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20220109236 — MILLIMETER-WAVE SCALABLE PLL-COUPLED ARRAY FOR PHASED-ARRAY APPLICATIONS

US 20220109236	Afzal et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S)	The Regents of the University of California (Oakland, California)
ASSIGNEE(S)	The Regents of the University of California (Oakland, California)
INVENTOR(S)	Hamidreza Afzal (Davis, California); Omeed Momeni (Davis, California); Rouzbeh Kananizadeh (Folsom, California); Razieh Abedi (Irvine, California); Payam Heydari (Irvine, California)
ABSTRACT	Techniques, systems and architectures for generating desired phase shifts in a phased array to control the directions of radiation in a wide range of angles are disclosed. Particularly, phased array architectures based on novel PLL-coupled phase shifting techniques for implementation in millimeter-wave (mm-wave) and sub-terahertz (sub-THz) operations range are described. In one aspect, a phased array including an array of unit cells is disclosed. In some embodiments, each unit cell in the array of unit cells includes a dual-nested PLL that is configured to effectuate phase locking and frequency locking to a reference signal from an adjacent unit cell. Moreover, each PLL includes control circuitry that can generate a wide range of phase shifts between adjacent unit cells to facilitate phased-array operations. Note that using the dual-nested PLL to generate a desired phase shift between adjacent radiating elements eliminates the use of conventional lossy phase shifters in the phased array.
FILED	Thursday, October 07, 2021
APPL NO	17/496626
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 3/36 (20130101) Original (OR) Class H01Q 21/0006 (20130101)
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20220109244 — MAGNETOELECTRIC NANOWIRE BASED ANTENNAS

US 20220109244	Andrew et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Engineering (ENG) Division of Industrial Innovation and Partnerships (IIP)
APPLICANT(S)	University of Florida Research Foundation, Inc. (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S)	Jennifer S. Andrew (Gainesville, Florida); Matthew Bauer (Gainesville, Florida); David P. Arnold (Gainesville, Florida)
ABSTRACT	Embodiments of the present disclosure integrate magnetoelectric nanowire arrays within antenna assemblies to form ultra-compact antennas An exemplary nanowire antenna array device comprises a first electrode positioned across a second electrode, wherein an electrode gap separates the first electrode and the second electrode; and a magnetoelectric nanowire connected to the first electrode and the second electrode across the electrode gap without substrate clamping, wherein the nanowire antenna array device receives or transmits electromagnetic waves through the magnetoelectric effect.
FILED	Monday, February 24, 2020
APPL NO	17/430948
CURRENT CPC	Antennas, i.e Radio Aerials H01Q 1/364 (20130101) H01Q 15/0086 (20130101) Original (OR) Class H01Q 21/061 (20130101)
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20220110012 — Predictive Weather-aware Communication Network Management

US 20220110012	Ostrometzky et al.
FUNDED BY	National Science Foundation (NSF) Directorate for Computer and Information Science and Engineering (CISE) Division of Computer and Network Systems (CNS)
APPLICANT(S)	The Trustees of Columbia University in the City of New York (New York, New York); RAMOT at Tel Aviv University Ltd. (Tel Aviv, Israel)
ASSIGNEE(S)
INVENTOR(S)	Jonathan Ostrometzky (Tel-aviv, Israel); Gil Zussman (New York, New York); Hagit Messer-Yaron (Kfar Saba, Israel); Dror Jacoby (Ramat Gan, Israel); Igor Kadota (New York, New York)
ABSTRACT	Disclosed are methods, systems, devices, and other implementations, including a method that includes obtaining measurement data from at least part of a wireless communication network during a first interval of time, with the measurement data including measurements indicating whether there are potential disturbances to operation of the wireless communication network. The method further includes determining, based on the obtained measurement data, predictive data representative of future performance of the wireless communication network at one or more future time instances subsequent to an end of the first interval of time, and managing resources of the wireless communication network based, at least in part, on the determined predictive data representative of the future performance of the wireless communication network at the one or more future time instances subsequent to the end of the first interval.
FILED	Wednesday, December 15, 2021
APPL NO	17/551643
CURRENT CPC	Transmission of Digital Information, e.g Telegraphic Communication H04L 41/16 (20130101) H04L 41/147 (20130101) H04L 45/22 (20130101) Wireless Communication Networks H04W 24/08 (20130101) Original (OR) Class H04W 28/18 (20130101)
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National Aeronautics and Space Administration (NASA)

20220104724 — COMPUTER-BASED DYNAMIC RATING OF ATAXIC BREATHING

US 20220104724	CATES et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	UNIVERSITY OF UTAH RESEARCH FOUNDATION (Salt Lake City, Utah)
ASSIGNEE(S)
INVENTOR(S)	Lara M. Brewer CATES (Salt Lake City, Utah); Robert J. FARNEY (Salt Lake City, Utah); Sean C. ERMER (Edwards, Colorado); Joseph A. ORR (Park City, Utah)
ABSTRACT	A computer system receives sensor measurements from a respiration sensor. The computer system generates a particular set of data features from the sensor measurements. The computer system then processes the particular set of data features through a computer-based ataxic breathing rating algorithm. The computer system displays on a user interface an ataxic breathing rating that is calculated from the computer-based ataxic breathing rating algorithm.
FILED	Tuesday, January 07, 2020
APPL NO	17/419133
CURRENT CPC	Diagnosis; Surgery; Identification A61B 5/743 (20130101) A61B 5/0816 (20130101) Original (OR) Class A61B 5/6819 (20130101) A61B 5/6823 (20130101) A61B 5/7264 (20130101) A61B 5/7278 (20130101) A61B 2562/0247 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) G16H 50/30 (20180101)
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20220105582 — CONTROL ASSEMBLY FABRICATION VIA BRAZING

US 20220105582	Zaffetti et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC)
APPLICANT(S)	Hamilton Sundstrand Corporation (Charlotte, North Carolina)
ASSIGNEE(S)
INVENTOR(S)	Mark A. Zaffetti (Suffield, Connecticut); Benjamin Abraham (Marlborough, Connecticut); Timothy Sauerhoefer (Broad Brook, Connecticut)
ABSTRACT	Systems and methods to control fabrication of an assembly involve a first end sheet having an interior surface and an exterior surface, opposite the interior surface. A system includes interior sheets, the interior sheets including a first interior sheet at one end of a stack of the interior sheets and including a last interior sheet at an opposite end of the stack of the two or more interior sheets, the first interior sheet being adjacent to the interior surface of the first end sheet, and a second end sheet having an interior surface and an exterior surface, opposite the interior surface. The last interior sheet is adjacent to the interior surface of the last end sheet, and the interior surface of the first end sheet or the second end sheet includes venting features, the venting features including holes or slots to channel heat, gas, or vapor during a brazing process.
FILED	Thursday, October 01, 2020
APPL NO	17/060359
CURRENT CPC	Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 1/0012 (20130101) B23K 1/018 (20130101) Original (OR) Class B23K 2101/14 (20180801)
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20220105680 — MODULAR EXPANDABLE 3D PRINTER

US 20220105680	Kim et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) Federally Funded Research and Development Center (FFRDC) Operated by California Institute of Technology (CALTECH) at Pasadena, CA National Science Foundation (NSF) Office of International Science and Engineering (OISE)
APPLICANT(S)	THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, (Las Vegas, Nevada)
ASSIGNEE(S)
INVENTOR(S)	Kwang J. Kim (Henderson, Nevada); Alexandrea Washington (Las Vegas, Nevada); Emma Chao (Henderson, Nevada); Justin Neubauer (Las Vegas, Nevada); Sophia Leon (Las Vegas, Nevada); Zachary Frank (Las Vegas, Nevada); Zakai Olsen (Las Vegas, Nevada)
ABSTRACT	A modular and expandable 3D printer frame includes frame members to be coupled together to form a base defining an inner area. Each frame member includes at least one coupling member to removably couple the frame member to another of the frame members. The printer frame further includes first modular plates to be disposed within the inner area, and second modular plates to be disposed within the inner area and removably coupled to the first modular plates. The first and second modular plates, when coupled together, define a printer footprint.
FILED	Wednesday, December 04, 2019
APPL NO	17/428424
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/25 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/295 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201)
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20220106050 — SYSTEM DEFINING A HYBRID POWER UNIT FOR THRUST GENERATION IN AN AERIAL VEHICLE AND METHOD FOR CONTROLLING THE SAME

US 20220106050	Resnick et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Parallel Flight Technologies, Inc. (Ben Lomond, California)
ASSIGNEE(S)
INVENTOR(S)	Joshua Resnick (Ben Lomond, California); David Adams (Ben Lomond, California); Robert Hulter (Ben Lomond, California); Seth McGann (Ben Lomond, California); Brian Eiseman (Ben Lomond, California)
ABSTRACT	One variation of a system for generating thrust at an aerial vehicle includes: a primary electric motor; a rotor coupled to the motor; an internal-combustion engine; a clutch interposed between the motor and an output shaft of the internal-combustion engine; an engine shroud defining a shroud inlet between the rotor and the internal-combustion engine, extending over the internal-combustion engine, and defining a shroud outlet opposite the rotor; a cooling fan coupled and configured to displace air through the engine shroud; and a local controller configured to receive a rotor speed command specifying a target rotor speed, adjust a throttle setpoint of the internal-combustion engine according to the target rotor speed and a state of charge of a battery in the aerial vehicle, and drive the primary electric motor to selectively output torque to the rotor and to regeneratively brake the rotor according to the target rotor speed.
FILED	Monday, September 13, 2021
APPL NO	17/474004
CURRENT CPC	Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 7/10 (20130101) B60L 15/20 (20130101) B60L 58/12 (20190201) B60L 2200/10 (20130101) Aeroplanes; Helicopters B64C 27/32 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 27/26 (20130101) B64D 31/06 (20130101) Original (OR) Class B64D 33/08 (20130101) B64D 2027/026 (20130101)
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20220106441 — POLY(ARYLENE ETHER) COMPOSITIONS AND ARTICLES INCORPORATING THE SAME

US 20220106441	Ghose et al.
FUNDED BY	National Aeronautics and Space Administration (NASA)
APPLICANT(S)	The Boeing Company (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S)	Sayata Ghose (Sammamish, Washington); Marcus Anthony Belcher (Sammamish, Washington); John W. Connell (Yorktown, Virginia)
ABSTRACT	Compositions including a poly(arylene ether), and compaction rollers for an automated fiber placement machine incorporating the composition are provided. The poly(arylene ether) may be a reaction product of at least one disubstituted benzophenone and at least one polyol. The at least one polyol may include at least one fluorinated diol. The composition may have a thermal conductivity of from about 0.2 to about 50 Watts per meter Kelvin (Wm⁻¹K⁻¹).
FILED	Friday, July 30, 2021
APPL NO	17/444124
CURRENT CPC	Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 70/384 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 65/34 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) C08K 7/06 (20130101) C08K 9/02 (20130101) C08K 2201/001 (20130101) C08K 2201/011 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/14 (20130101)
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20220106944 — FIBER-FED ADVANCED PULSED PLASMA THRUSTER (FPPT)

US 20220106944	Woodruff et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	CU Aerospace, LLC (Champaign, Illinois)
ASSIGNEE(S)	CU Aerospace, LLC (Champaign, Illinois)
INVENTOR(S)	Curtis Woodruff (Savoy, Illinois); Darren King (Champaign, Illinois); Rodney Burton (Northbrook, Illinois); David L. Carroll (Champaign, Illinois); Magdalena Parta (Urbana, Illinois)
ABSTRACT	A Fiber-fed Pulsed Plasma Thruster (FPPT) has an anode, a coaxial insulator, and a fiber propellant feed system. At least two cathodes insulated from each other are configured about the coaxial insulator to define an interior profile shaped into a nozzle region. At least one igniter fitted through each cathode. Wherein when the igniters are triggered, the igniters expel electrons toward the anode to ignite a primary high energy discharge between the anode and the cathodes thereby creating a plasma that vaporizes the fiber propellant. The dissociated fiber propellant combines with the primary high energy discharge to create a partially or fully ionized plasma, that is electromagnetically and electrothermally accelerated to produce predominantly {right arrow over (j)}×{right arrow over (B)}{right arrow over (j)}×{right arrow over (B)} thrust.
FILED	Wednesday, December 22, 2021
APPL NO	17/559178
CURRENT CPC	Cosmonautics; Vehicles or Equipment Therefor B64G 1/405 (20130101) Producing a Reactive Propulsive Thrust, Not Otherwise Provided for F03H 1/0087 (20130101) Original (OR) Class
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20220107292 — ON-LINE SUPPRESSOR

US 20220107292	Dasgupta et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC)
APPLICANT(S)	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (AUSTIN, Texas)
ASSIGNEE(S)
INVENTOR(S)	Purnendu K. Dasgupta (Arlington, Texas); Bikash Chouhan (Arlington, Texas); Joseph Ray (Midlothian, Texas)
ABSTRACT	A device for ion chromatography comprises a tube with an inlet opening and an outlet opening and an inner diameter from about 40 microns to about 10 microns. There is an aperture through one side of the tube into a lumen of the tube. At least a portion of the inner surface of the tube has a first charge. An ion exchange barrier covers the aperture on an outside surface of the tube. The inner surface of the tube, from the inlet opening to the aperture, is coated with ion exchange particles having a diameter ranging from about 30 nm to about 200 nm. The ion exchange particles have a second charge opposite the first charge. The inner surface of the tube, from the outlet opening to the aperture, is not coated with ion exchange particles.
FILED	Tuesday, October 06, 2020
APPL NO	17/063873
CURRENT CPC	Separation B01D 15/361 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/38 (20130101) Original (OR) Class G01N 2030/8458 (20130101)
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Non-Profit Organization (NPO)

20220105264 — INSTRUMENTS AND METHODS FOR LOADING CELLS INTO IMPLANTABLE DEVICES

US 20220105264	Green et al.
FUNDED BY	Non-Profit Organization (NPO) California Institute for Regenerative Medicine (CIRM) U.S. State Government State of California
APPLICANT(S)	ViaCyte, Inc. (San Diego, California)
ASSIGNEE(S)	ViaCyte, Inc. (San Diego, California)
INVENTOR(S)	Chad Green (San Diego, California); Laura Martinson (San Diego, California); Erik Olson (San Diego, California); Val Anthony Bellora (San Diego, California); Leah Elliott (San Diego, California); Richard Alexander Grant (San Diego, California); Donald Koenig (San Diego, California); Giacomo Strollo (San Diego, California)
ABSTRACT	Embodiments herein describe tools, instruments and methods for aseptic loading, dispensing and/or delivering cells into an implantable device and aseptically and selectively sealing a device inside a sterile package as well as and storing and preparing for shipment the cell-filled device.
FILED	Wednesday, December 15, 2021
APPL NO	17/551536
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/022 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) A61M 5/14276 (20130101) Original (OR) Class A61M 37/0069 (20130101) A61M 2209/045 (20130101) Machines, Apparatus or Devices For, or Methods Of, Packaging Articles or Materials; Unpacking B65B 3/003 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0676 (20130101)
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20220105570 — Pulse Transfer for Large Area Metal Fusion System

US 20220105570	Hazlewood et al.
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Non-Profit Organization (NPO) National Center for Manufacturing Sciences Inc. (NCMS)
APPLICANT(S)	3D Systems, Inc. (Rock Hill, South Carolina)
ASSIGNEE(S)
INVENTOR(S)	Bryon Robert Hazlewood (San Diego, California); Jose Julio Doval (Escondido, California); Evan C. Freiburg (San Diego, California)
ABSTRACT	A 3D printing system includes a print engine, a powder dispenser, and a controller. The print engine includes a chassis defining an inner chamber with a docking chamber, a build box with a build plate, an energy beam system, and a powder track coater (PTC) coupled to a gantry. The controller is configured to: (A) operate the gantry and the PTC to selectively dispense a track of powder over the build plate, (B) operate the gantry to transport the PTC to the docking station, (C) operate the energy beam system to selectively fuse the track of powder, and (D) concurrent with operating the energy beam to (D1) measure a level of powder in the PTC and (D2) if the level of powder in the PTC is below a predetermined threshold, operate the powder dispenser to transfer a controlled volume of powder to the PTC.
FILED	Tuesday, September 28, 2021
APPL NO	17/487270
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/85 (20210101) B22F 12/57 (20210101) Original (OR) Class B22F 12/70 (20210101) Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/123 (20130101) B23K 26/342 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) B33Y 50/02 (20141201)
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20220105571 — Three-Dimensional Print Engine with Large Area Build Plane Having Optimized Gas Flow Director Structures

US 20220105571	Doval
FUNDED BY	Department of Defense (DOD) Department of the Army (DOA) Combat Capabilities Development Command (CCDC) Army Research Laboratory (CCDC ARL) Non-Profit Organization (NPO) National Center for Manufacturing Sciences Inc. (NCMS)
APPLICANT(S)	3D Systems, Inc. (Rock Hill, South Carolina)
ASSIGNEE(S)
INVENTOR(S)	Jose Julio Doval (Escondido, California)
ABSTRACT	A three-dimensional (3D) print engine includes (A) a plurality of walls laterally defining a build chamber, (B) a build box including a build plate, (C) a powder dispenser, (D) a beam system for fusing layers of powder, (E) a peripheral plate disposed between the build plate and the plurality of walls and having an upper surface, (F) a gas inlet that ejects a gas flow stream that passes over the build plate and the peripheral plate, (G) a gas outlet that receives the gas flow stream, (H) a plurality of projecting structures mounted to and extending above the upper surface of the peripheral plate, and (I) a gas handling system coupled to the gas inlet and gas outlet. The plurality of projecting structures shape the flow field of the gas flow stream to provide a more uniform velocity of gas flow velocities above the build plane.
FILED	Tuesday, September 28, 2021
APPL NO	17/487211
CURRENT CPC	Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 12/38 (20210101) B22F 12/70 (20210101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/16 (20130101) B23K 26/083 (20130101) B23K 26/342 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201)
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20220109363 — SHORT PULSE GATE SIGNAL VOLTAGE BALANCING IN SERIES-CONNECTED MOSFETS

US 20220109363	Lin et al.
FUNDED BY	Non-Profit Organization (NPO) Manufacturing USA (MFGUSA) PowerAmerica(PWRAMERICA)
APPLICANT(S)	VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (Blacksburg, Virginia)
ASSIGNEE(S)
INVENTOR(S)	Xiang Lin (Blacksburg, Virginia); Dong Dong (Blacksburg, Virginia); Rolando Burgos (Blacksburg, Virginia)
ABSTRACT	A voltage balancing circuit for use in a power converter is described. In one example, a power converter includes series-connected switching transistors for power conversion, and a voltage balancing control loop. The voltage balancing control loop includes a measurement circuit electrically coupled to a transistor in the pair of series-connected switching transistors. The measurement circuit is electrically coupled to measure a body voltage reference of the transistor. The voltage balancing control loop also includes a balancing circuit configured to generate a balancing pulse signal for adjusting a voltage across the transistor using the body voltage reference, and a circuit configured to combine the balancing pulse signal with a gate drive pulse signal for the transistor, to form a balanced gate drive pulse signal for the transistor. The balanced gate drive pulse signal helps to equalize the body diode voltages of the series-connected switching transistors, particularly during “off” periods.
FILED	Tuesday, October 06, 2020
APPL NO	17/064080
CURRENT CPC	Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/08 (20130101) Original (OR) Class H02M 2001/0051 (20130101)
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Small Business Administration (SBA)

20220105362 — RE-ACTIVATABLE RADIATION SOURCE FOR BRACHYTHERAPY

US 20220105362	Flynn et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Cancer Institute (NCI) National Institute of Biomedical Imaging and Bioengineering (NIBIB) Small Business Administration (SBA) Small Business Technology Transfer (STTR)
APPLICANT(S)	UNIVERSITY OF IOWA RESEARCH FOUNDATION (IOWA CITY, Iowa)
ASSIGNEE(S)
INVENTOR(S)	Ryan T. Flynn (Iowa City, Iowa); QUENTIN E. ADAMS (Iowa City, Iowa); KAROLYN M. HOPFENSPERGER (lowa City, Iowa)
ABSTRACT	A method can comprise irradiating an active element having an initial total activity between zero and thirty curies of ytterbium-169 and a volume between about two cubic millimeters and about four cubic millimeters. Irradiation can be ceased before the active element surpasses a total activity of thirty curies and an activity concentration of ten curies per cubic millimeter.
FILED	Tuesday, February 11, 2020
APPL NO	17/428035
CURRENT CPC	Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/1007 (20130101) Original (OR) Class A61N 2005/1008 (20130101) A61N 2005/1022 (20130101)
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20220106050 — SYSTEM DEFINING A HYBRID POWER UNIT FOR THRUST GENERATION IN AN AERIAL VEHICLE AND METHOD FOR CONTROLLING THE SAME

US 20220106050	Resnick et al.
FUNDED BY	National Aeronautics and Space Administration (NASA) NASA Shared Services Center (NSSC) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Parallel Flight Technologies, Inc. (Ben Lomond, California)
ASSIGNEE(S)
INVENTOR(S)	Joshua Resnick (Ben Lomond, California); David Adams (Ben Lomond, California); Robert Hulter (Ben Lomond, California); Seth McGann (Ben Lomond, California); Brian Eiseman (Ben Lomond, California)
ABSTRACT	One variation of a system for generating thrust at an aerial vehicle includes: a primary electric motor; a rotor coupled to the motor; an internal-combustion engine; a clutch interposed between the motor and an output shaft of the internal-combustion engine; an engine shroud defining a shroud inlet between the rotor and the internal-combustion engine, extending over the internal-combustion engine, and defining a shroud outlet opposite the rotor; a cooling fan coupled and configured to displace air through the engine shroud; and a local controller configured to receive a rotor speed command specifying a target rotor speed, adjust a throttle setpoint of the internal-combustion engine according to the target rotor speed and a state of charge of a battery in the aerial vehicle, and drive the primary electric motor to selectively output torque to the rotor and to regeneratively brake the rotor according to the target rotor speed.
FILED	Monday, September 13, 2021
APPL NO	17/474004
CURRENT CPC	Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 7/10 (20130101) B60L 15/20 (20130101) B60L 58/12 (20190201) B60L 2200/10 (20130101) Aeroplanes; Helicopters B64C 27/32 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 27/24 (20130101) B64D 27/26 (20130101) B64D 31/06 (20130101) Original (OR) Class B64D 33/08 (20130101) B64D 2027/026 (20130101)
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20220106547 — COMPOSITIONS AND METHODS OF USING PARTIAL GEL LAYERS IN A MICROFLUIDIC DEVICE

US 20220106547	Petropolis et al.
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Institute on Alcohol Abuse and Alcoholism (NIAAA) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Emulate, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S)	Debora Barreiros Petropolis (Cambridge, Massachusetts); Remi Villenave (Boston, Massachusetts); Janna Nawroth (Boston, Massachusetts); Tanvi Shroff (Cambridge, Massachusetts); S. Jordan Kerns (Reading, Massachusetts); Antonio Varone (West Roxbury, Massachusetts)
ABSTRACT	The present invention relates to the use of gels for cell cultures, including but not limited to microfluidic devices and transwell devices, for culturing cells, such as organ cells, e.g. airway cells, intestinal cells, etc., and co-culturing cells, (e.g. parenchymal cells and endothelial cells, etc). As one example, the use of gels results in improved lung cell cultures, such as when using transwells and microfluidic devices, (e.g. for culturing healthy airway epithelial cells, culturing diseased airway epithelial cells, e.g., CF epithelial cells that are ciliated). The present invention relates to fluidic devices, methods and systems for use with gel layers within a microfluidic device. In particular, a partial gel layer is disposed within a microchannel of a microfluidic device. For example, a partial gel layer has a thickness ranging between approximately 20-100 μm. A dilute partial gel layer of less than 100 μm may be formed from a polymer solution of 0.5 mg/ml. A cell-permeable partial gel layer having a thickness ranging between approximately 20-50 μm may be formed from a polymer solution of 1-3 mg/ml. A partial gel layer may be formed by a hydrodynamic shearing technique. Such thin gel layers can support a variety of cell cultures, including but not limited to single cells, cell populations, cell layers, differentiated cell layers, and/or primary tissues. The present invention is related to the field of imaging and image processing. In particular, the invention is related to imaging that supports the determination of cell membrane cilia beating frequency. For example, methods described herein encompass cilia beat frequency in the context of membrane region and/or distances between regions. Alternatively, the methods described here encompass cilia beat synchrony and correlation of beat frequency between cell membrane regions.
FILED	Friday, October 29, 2021
APPL NO	17/514659
CURRENT CPC	Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) Original (OR) Class C12M 25/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0688 (20130101) C12N 2533/54 (20130101) C12N 2535/00 (20130101)
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20220106630 — Nanopore Platform for DNA/RNA Oligo Detection Using an Osmium Tagged Complementary Probe

US 20220106630	Kanavarioti
FUNDED BY	Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) Small Business Administration (SBA) Small Business Innovation Research (SBIR)
APPLICANT(S)	Anastassia Kanavarioti (El Dorado Hills, California)
ASSIGNEE(S)
INVENTOR(S)	Anastassia Kanavarioti (El Dorado Hills, California)
ABSTRACT	Provided for herein is a method for detecting the presence of a nucleic acid target molecule in a biological sample. In certain aspects, the method comprises contacting a test sample that comprises (i) a biological sample comprising a nucleic acid target molecule and (ii) an osmylated single-stranded oligonucleotide probe comprising at least one pyrimidine residue covalently bonded to a substituted or unsubstituted Osmium tetroxide (OsO₄)-2,2′-bypyridine group (OsBp group).
FILED	Friday, September 03, 2021
APPL NO	17/466931
CURRENT CPC	Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) C12Q 1/6832 (20130101) Original (OR) Class
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Department of Agriculture (USDA)

20220106535 — Lubricating Base Oils from Esterified Alkoxylated Polyols Using Saturated Long-Chain Fatty Acids

US 20220106535	Hunt et al.
FUNDED BY	Department of Energy (DOE) Office of Science (DOE-SC) National Science Foundation (NSF) Directorate of Technology Translational Impacts (TI) Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA)
APPLICANT(S)	Tetramer Technologies, LLC (Pendleton, South Carolina)
ASSIGNEE(S)	Tetramer Technologies, LLC (Pendleton, South Carolina)
INVENTOR(S)	Zachary Hunt (Simpsonville, South Carolina); Peter Gennaro (Mount Pleasant, South Carolina); Jeffrey R. DiMaio (Pendleton, South Carolina); Benjamin Bergmann (Liberty, South Carolina)
ABSTRACT	The present disclosure relates to methods and compositions for making bio-based, biodegradable, and non-bioaccumulating lubricating base oils generated by esterifying alkoxylated polyols (average alkoxylation ≥3) with long-chain (≥C14) saturated and unsaturated fatty acids (FA) or fatty acids modified using industry recognized techniques.
FILED	Thursday, December 16, 2021
APPL NO	17/552418
CURRENT CPC	Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 101/04 (20130101) C10M 105/44 (20130101) Original (OR) Class C10M 2207/301 (20130101) C10M 2209/043 (20130101) Indexing Scheme Associated With Subclass C10M Relating to Lubricating Compositions C10N 2040/04 (20130101)
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20220106775 — ROBUST WATER TRADING AND IRRIGATION PERFORMANCE METER MEASUREMENT SYSTEM

US 20220106775	Henry
FUNDED BY	Department of Agriculture (USDA) Natural Resources Conservation Service (NRCS)
APPLICANT(S)	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Lttle Rock, Arkansas)
ASSIGNEE(S)
INVENTOR(S)	Christopher G. Henry (Stuttgart, Arkansas)
ABSTRACT	A redundant meter measurement system includes a first water sensor configured to measure a first set of water use data and a second water sensor configured to measure a second set of water use data. The system also includes a controller communicatively coupled to the first water sensor and the second water sensor. The controller is configured to receive the first set of water use data from the first water sensor and receive the second set of water use data from the second water sensor. The controller is also configured to store the first set of water use data and the second set of water use data as a collection of water use data. The controller is also configured to enable transmission of the collection of water use data to a remote device.
FILED	Thursday, August 05, 2021
APPL NO	17/394675
CURRENT CPC	Installations or Methods for Obtaining, Collecting, or Distributing Water E03B 7/072 (20130101) Original (OR) Class Measuring Volume, Volume Flow, Mass Flow or Liquid Level; Metering by Volume G01F 15/063 (20130101)
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Department of Commerce (DOC)

20220108735 — TEMPORAL MEMORY SYSTEMS AND METHODS

US 20220108735	MADHAVAN
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S)	Advait MADHAVAN (Bethesda, Maryland)
ABSTRACT	Various design concepts, circuit implementations, and methods are provided for implementing temporal memory. For example, temporal memories may perform both read and write operations using time-encoded wavefronts. A temporal memory may include a group of tunable delay components that “store” time-encoding information. Using these delay components, the memory can perform a “read” operation by outputting wavefronts having the same or similar time-encoding as the stored wavefronts. Temporal memories may allow for more energy-cost-efficient operation and may serve as building blocks for more complex temporal computational circuits.
FILED	Friday, October 01, 2021
APPL NO	17/492524
CURRENT CPC	Static Stores G11C 7/12 (20130101) G11C 7/222 (20130101) Original (OR) Class G11C 7/1012 (20130101) G11C 7/1069 (20130101) G11C 7/1096 (20130101) Pulse Technique H03K 19/20 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

20220108736 — TIMING-BASED COMPUTER ARCHITECTURE SYSTEMS AND METHODS

US 20220108736	MADHAVAN et al.
FUNDED BY	Department of Commerce (DOC) National Institute of Standards and Technology (NIST)
APPLICANT(S)	University of Maryland, College Park (College Park, Maryland); THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF COMMERCE (WASHINGTON, District of Columbia)
ASSIGNEE(S)
INVENTOR(S)	Advait MADHAVAN (Bethesda, Maryland); Matthew William DANIELS (Silver Spring, Maryland); Mark David STILES (Silver Spring, Maryland)
ABSTRACT	Systems and methods are provided herein that implement and utilize temporal state machines and other temporal computational/memory circuits. For example, a temporal state machine is provided that comprises a temporal computational unit comprising at least one circuit to perform a time-domain operation, and a temporal memory unit. Both the temporal computational unit and temporal memory unit can operate using solely, or partially, time-encoded wavefronts. The computation unit accesses time-encoded wavefronts from the memory and can output and write time-encoded wavefronts back to the memory.
FILED	Friday, October 01, 2021
APPL NO	17/492526
CURRENT CPC	Electric Digital Data Processing G06F 17/16 (20130101) Static Stores G11C 5/06 (20130101) G11C 7/222 (20130101) Original (OR) Class G11C 7/1069 (20130101) G11C 7/1096 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

National Security Agency (NSA)

20220105479 — Re-Mixing Dispenser for Liquids in Plunger Tubes

US 20220105479	Buss et al.
FUNDED BY	National Security Agency (NSA) Maryland Procurement Office (MPO)
APPLICANT(S)	Southwest Research Institute (San Antonio, Texas)
ASSIGNEE(S)
INVENTOR(S)	Cole Buss (San Antonio, Texas); Eric Kroeger (San Antonio, Texas); Taylor W. Batholomew (San Antonio, Texas)
ABSTRACT	A re-mixing dispenser for containing and dispensing a liquid. The dispenser may have one or more tubes, each containing a different liquid. At least one of the liquids may be re-mixed in situ, using a special two-piece plunger and plunger rod. A mixing piece of the two-piece plunger is moveable independently of a top piece and has blades that allow it to move through the liquid. A plunger rod is removably attached to the mixing piece and is operable to move the mixing piece up and down within the tube during mixing. The two plunger pieces are joined and moved as a single plunger during dispensing.
FILED	Monday, October 05, 2020
APPL NO	17/062807
CURRENT CPC	Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 13/0027 (20130101) Original (OR) Class B01F 2215/0039 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 1/04 (20130101) B65D 81/325 (20130101) B65D 81/3283 (20130101) B65D 83/0005 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

20220107911 — APPARATUSES, METHODS, AND SYSTEMS FOR OPERATIONS IN A CONFIGURABLE SPATIAL ACCELERATOR

US 20220107911	FLEMING et al.
FUNDED BY	Department of Defense (DOD) National Security Agency (NSA)
APPLICANT(S)	Intel Corporation (Santa Clara, California)
ASSIGNEE(S)
INVENTOR(S)	Kermin E. FLEMING (Hudson, Massachusetts); Simon C. STEELY (Hudson, New Hampshire); Kent D. GLOSSOP (Nashua, New Hampshire); Mitchell DIAMOND (Shrewsbury, Massachusetts); Benjamin KEEN (Marlborough, Massachusetts); Dennis BRADFORD (Portland, Oregon); Fabrizio Petrini (Menlo Park, California); Barry TANNENBAUM (Nashua, New Hampshire); Yongzhi ZHANG (Wayland, Massachusetts)
ABSTRACT	Systems, methods, and apparatuses relating to operations in a configurable spatial accelerator are described. In one embodiment, a configurable spatial accelerator includes a first processing element that includes a configuration register within the first processing element to store a configuration value that causes the first processing element to perform an operation according to the configuration value, a plurality of input queues, an input controller to control enqueue and dequeue of values into the plurality of input queues according to the configuration value, a plurality of output queues, and an output controller to control enqueue and dequeue of values into the plurality of output queues according to the configuration value.
FILED	Tuesday, December 14, 2021
APPL NO	17/550875
CURRENT CPC	Electric Digital Data Processing G06F 9/30145 (20130101) G06F 13/4027 (20130101) Original (OR) Class G06F 15/7867 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Homeland Security (DHS)

20220107244 — THERMAL EXTRACTION APPARATUS WITH HIGH VOLUME SAMPLING TRAP

US 20220107244	Cho
FUNDED BY	Department of Homeland Security (DHS)
APPLICANT(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S)	The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S)	Inho Cho (Egg Harbor Township, New Jersey)
ABSTRACT	In an example, a thermal extraction apparatus includes: a housing having a gas inlet and a gas outlet to receive a gas flow through the housing from the gas inlet to the gas outlet, and a side opening to receive a sample collector, having a sample collector adsorbent containing a vapor sample, into a sample collector location; a pump to generate the gas flow; a heater to heat the sample collector adsorbent of the sample collector to a temperature sufficient to release the vapor sample; a thermal desorption (TD) tube connected with the gas outlet of the housing to receive the gas flow downstream of the sample collector and collect the vapor sample released from the sample collector adsorbent of the sample collector; and a cooling member in heat exchange with the TD tube to cool the TD tube.
FILED	Monday, December 20, 2021
APPL NO	17/556543
CURRENT CPC	Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/44 (20130101) G01N 1/2214 (20130101) Original (OR) Class G01N 1/2247 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of Veterans Affairs (DVA)

20220105128 — METHODS OF TREATING VIRAL INFECTIONS AFFECTING THE RESPIRATORY TRACT USING TOPICALLY ADMINISTERED LITHIUM AGENTS

US 20220105128	Ganio
FUNDED BY	Department of Veterans Affairs (DVA)
APPLICANT(S)	United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S)	Carl Ganio (Wilmington, North Carolina)
ABSTRACT	This disclosure relates to topical lithium agents including inhalable lithium agents for treating a viral infection characterized by a cytokine storm in the respiratory tract of a subject such as a human. Topical lithium formulations can be used to mitigate such viral infections, including coronavirus infections.
FILED	Tuesday, October 05, 2021
APPL NO	17/494230
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 33/14 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/02 (20180101)
VIEW PATENT	@ USPTO: Full Text PDF

Department of the Interior (DOI)

20220105470 — Electromagnetic Induction Pervaporation Membrane

US 20220105470	Zhang et al.
FUNDED BY	Department of the Interior (DOI) Bureau of Reclamation (USBR)
APPLICANT(S)	New Jersey Institute of Technology (Newark, New Jersey)
ASSIGNEE(S)	New Jersey Institute of Technology (Newark, New Jersey)
INVENTOR(S)	Wen Zhang (Livingston, New Jersey); Weihua Qing (Kearny, New Jersey)
ABSTRACT	A pervaporation apparatus and method for liquid mixture separation are disclosed. The pervaporation disclosed utilizes an interfacial-heating membrane utilizing induction heating to provide temperature differences across the membrane for driving liquid mixture separation. The pervaporation system may include an electromagnetic induction heating device that is placed close to or encapsulated in a membrane module wherein one or more membranes with surfaces containing ferromagnetic or other induction-responsive materials. The membrane surface generates localized heat owing to the presence of a ferromagnetic composition that converts electric energy from an induction source to thermal energy. The ferromagnetic composition could include, without limitation, metals, metal alloys, composite materials, nanocomposite materials, nanoparticles, meshes, and combinations thereof.
FILED	Monday, September 27, 2021
APPL NO	17/485932
CURRENT CPC	Separation B01D 8/00 (20130101) B01D 61/362 (20130101) Original (OR) Class B01D 69/02 (20130101) B01D 69/10 (20130101) B01D 69/12 (20130101) B01D 2313/22 (20130101) B01D 2325/46 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

U.S. State Government

20220105264 — INSTRUMENTS AND METHODS FOR LOADING CELLS INTO IMPLANTABLE DEVICES

US 20220105264	Green et al.
FUNDED BY	Non-Profit Organization (NPO) California Institute for Regenerative Medicine (CIRM) U.S. State Government State of California
APPLICANT(S)	ViaCyte, Inc. (San Diego, California)
ASSIGNEE(S)	ViaCyte, Inc. (San Diego, California)
INVENTOR(S)	Chad Green (San Diego, California); Laura Martinson (San Diego, California); Erik Olson (San Diego, California); Val Anthony Bellora (San Diego, California); Leah Elliott (San Diego, California); Richard Alexander Grant (San Diego, California); Donald Koenig (San Diego, California); Giacomo Strollo (San Diego, California)
ABSTRACT	Embodiments herein describe tools, instruments and methods for aseptic loading, dispensing and/or delivering cells into an implantable device and aseptically and selectively sealing a device inside a sterile package as well as and storing and preparing for shipment the cell-filled device.
FILED	Wednesday, December 15, 2021
APPL NO	17/551536
CURRENT CPC	Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/022 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) A61M 5/14276 (20130101) Original (OR) Class A61M 37/0069 (20130101) A61M 2209/045 (20130101) Machines, Apparatus or Devices For, or Methods Of, Packaging Articles or Materials; Unpacking B65B 3/003 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0676 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

Government Rights Acknowledged

20220105171 — MATERIALS AND METHODS FOR RESPIRATORY DISEASE CONTROL IN CANINES

US 20220105171	CRAWFORD et al.
FUNDED BY
APPLICANT(S)	UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, Florida); CORNELL RESEARCH FOUNDATION, INC. (Ithaca, New York); The Government of The United States of America as represented by The Secretary of The Department of (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S)	PATTI CYNTHIA CRAWFORD (GAINESVILLE, Florida); PAUL J. GIBBS (GAINESVILLE, Florida); EDWARD J. DUBOVI (ITHACA, New York); RUBEN OMAR DONIS (ATLANTA, Georgia); JACQUELINE KATZ (ATLANTA, Georgia); ALEXANDER I. KLIMOV (ATLANTA, Georgia); NALLAKANNU P. LAKSHMANAN (MILLSBORO, Delaware); MELISSA ANNE LUM (MILLSBORO, Delaware); DANIEL GHISLENA EMIEL GOOVAERTS (BOXMEER, Netherlands); MARK WILLIAM MELLENCAMP (DESOTO, Kansas); NANCY J. COX (ATLANTA, Georgia); WILLIAM L. CASTLEMAN (GAINESVILLE, Florida)
ABSTRACT	The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.
FILED	Friday, September 10, 2021
APPL NO	17/471370
CURRENT CPC	Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) Original (OR) Class A61K 2039/53 (20130101) A61K 2039/552 (20130101) A61K 2039/5252 (20130101) A61K 2039/55555 (20130101) A61K 2039/55566 (20130101) Peptides C07K 14/005 (20130101) C07K 16/1018 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2710/24043 (20130101) C12N 2760/16121 (20130101) C12N 2760/16122 (20130101) C12N 2760/16134 (20130101) C12N 2760/16151 (20130101) C12N 2760/16171 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) G01N 2333/11 (20130101)
VIEW PATENT	@ USPTO: Full Text PDF

How To Use This Page

What You'll Find On This Page

THE FEDINVENT PATENT APPLICATION DETAILS PAGE

Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.

This week's information is published in the FedInvent Patents report for Thursday, April 07, 2022.

The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.

HOW IS THE INFORMATION ORGANIZED?

Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.

WHAT INFORMATION WILL I FIND?

THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:

FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:

Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)

We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.

APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.

Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:

APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC

APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)

INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.

ABSTRACT
The abstract is presented as it appears on the patent.

FILED
The date the patent application including the day of the week.

APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.

ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:

3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices

You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.

CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.

The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.

The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.

A61B 1/149 (20130101)
A61B 1/71 (20130101)
A61B 1/105 (20130101)

The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.

VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.

HOW DO I FIND A SPECIFIC PATENT ON A PAGE?

You can use the Command F or Control F to find a specific patent you are interested in.

HOW DO I GET HERE?

You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.

You can also reach this page using the weekly page link that looks like this:

https://wayfinder.digital/fedinvent/patents-2022/details-patents-20220407.html

Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.

Download a copy of the How To Use This Page

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