FedInvent™ Patent Applications
Application Details for Thursday, April 14, 2022
This page was updated on Friday, April 15, 2022 at 04:43 PM GMT
Department of Health and Human Services (HHS)
| US 20220110548 | RADWIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (MADISON, Wisconsin) |
| INVENTOR(S) | ROBERT RADWIN (WAUNAKEE, Wisconsin); YIN LI (MADISON, Wisconsin); RUNYU GREENE (MADISON, Wisconsin); FANGZHOU MU (MADISON, Wisconsin); YU HEN HU (MIDDLETON, Wisconsin) |
| ABSTRACT | A monitoring or tracking system may include an input port and a controller in communication with the input port. The input port may receive data from a data recorder. The data recorder is optionally part of the monitoring system and in some cases includes at least part of the controller. The controller may be configured to receive data via the input port, the data being related to a subject lifting an object. Using the data, the controller may locate body parts of the subject while the subject is lifting the object and monitor body movements of the subject during the lift. Further, the controller may be configured to determine a value related to a load of the object based on the body movements monitored. The controller may output via the output port the value determined and/or lift assessment information for the subject. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497676 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/1113 (20130101) A61B 5/1128 (20130101) Original (OR) Class A61B 5/7267 (20130101) A61B 2503/20 (20130101) A61B 2560/02 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110565 | Gardner et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Trustees of Boston University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy James Gardner (Brookline, Massachusetts); Stuart F. Cogan (Dallas, Texas) |
| ABSTRACT | Manufacturing a neural interface device. Forming a neural interface probe of an implantable microelectrode body. PECVD a first amorphous silicon carbide insulation layer, forming a thin film metal trace and interface pad on the first layer, the pad on a portion of the trace. PECVD a second amorphous silicon carbide insulation layer on the first layer and covering the trace and the pad. Forming an opening in the second layer to expose the pad to an ambient environment. Patterning the first and second layers to define the neural interface probe. The probe has a rectangular cuboid shape, a cross-sectional area perpendicularly transverse to a long axis length of the probe and through any perpendicularly transverse cross-section along the long axis length is less than about 50 microns. The layers are the principle material of construction of the probe. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/559835 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/24 (20210101) Original (OR) Class A61B 5/6868 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 31/06 (20130101) A61L 31/10 (20130101) A61L 31/14 (20130101) A61L 31/022 (20130101) A61L 31/028 (20130101) A61L 31/088 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/50 (20130101) C23C 16/56 (20130101) C23C 16/325 (20130101) C23C 28/00 (20130101) C23C 28/32 (20130101) C23C 28/341 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110580 | Bashyam et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ashvin Bashyam (Austin, Texas); Christopher Frangieh (Cambridge, Massachusetts); Michael J. Cima (Winchester, Massachusetts) |
| ABSTRACT | Methods for assessing steatosis and fibrosis in a patient's liver include (i) measuring a diffusion-weighted relaxometry signal of the liver, or portion thereof; and determining a fibrosis content of the liver or portion thereof based on the measured diffusion-weighted relaxometry signal, or (ii) measuring a relaxometry signal of the liver, or portion thereof; and determining a fat content of the liver or portion thereof based on the measured relaxometry signal. A system for such non-invasive sensing includes a static magnetic field source; RF transmitter coils connected to a pulse sequence generator; RF receiver coils configured to detect a magnetic field generated within liver tissues; and a signal acquisition and processor system configured to acquire signals from the RF receiver coils and perform a relaxation time (T2) relaxometry measurement, wherein the RF transmitter coils and pulse sequence generator are configured to apply a varying magnetic field to the liver tissues. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/496879 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4244 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/50 (20130101) G01R 33/56341 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110588 | Gao et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Wei Gao (Pasadena, California); You Yu (Pasadena, California) |
| ABSTRACT | An auto-powered biosensor capable detecting a target molecule, and a method of powering the same, wherein the biosensor is fabricated with a microfluidics layer, a multimodal sensing layer comprising a biofuel cell and an electrode, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon. |
| FILED | Thursday, April 22, 2021 |
| APPL NO | 17/237925 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/002 (20130101) A61B 5/0004 (20130101) A61B 5/1486 (20130101) A61B 5/6832 (20130101) Original (OR) Class A61B 5/14517 (20130101) A61B 10/0051 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220110737 — SYSTEMS, DEVICES, AND METHODS FOR THE RETRIEVAL OF AN IMPLANT IN THE PROSTATIC URETHRA
| US 20220110737 | Mehta et al. |
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| FUNDED BY |
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| APPLICANT(S) | ZENFLOW, INC. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shreya Mehta (San Francisco, California); Aaron M. Weiss (Oakland, California); Austin Michael Bly (San Clemente, California) |
| ABSTRACT | Systems, devices, and methods are provided for retrieval of an implant from the prostatic urethra. Embodiments of retrieval systems can include a device for insertion into the patient and a proximal control device for use in grasping a portion of the implant and withdrawing the implant into a lumen of the retrieval system. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/495996 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 2017/00274 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/04 (20130101) Original (OR) Class A61F 2002/047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110836 | Yelick et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRUSTEES OF TUFTS COLLEGE (Medford, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pamela C. Yelick (Boston, Massachusetts); Ali Khademhosseini (Cambridge, Massachusetts) |
| ABSTRACT | A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557483 |
| CURRENT CPC | Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 5/40 (20170201) Preparations for Medical, Dental, or Toilet Purposes A61K 6/56 (20200101) A61K 6/62 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110893 | Wardell et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Suzanne E. Wardell (Durham, North Carolina); Erik R. Nelson (Champaign, Illinois); Donald P McDonnell (Chapel Hill, North Carolina) |
| ABSTRACT | Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/558731 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/40 (20130101) A61K 31/136 (20130101) A61K 31/137 (20130101) Original (OR) Class A61K 31/138 (20130101) A61K 31/565 (20130101) A61K 31/4196 (20130101) A61K 31/4535 (20130101) A61K 31/5685 (20130101) A61K 45/06 (20130101) A61K 2121/00 (20130101) Acyclic or Carbocyclic Compounds C07C 217/78 (20130101) C07C 217/84 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110897 | Nobile et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clarissa J. Nobile (Merced, California); Megha Gulati (Merced, California) |
| ABSTRACT | The disclosure provides compositions comprising amino acids, individually and in combination, and methods of making the compositions and methods of using the compositions as pharmaceutically active agents to, inter alia, treat disease in animals, including humans. |
| FILED | Tuesday, December 03, 2019 |
| APPL NO | 17/295656 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) Original (OR) Class A61K 47/10 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110931 | Reddy |
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| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | P. Hemachandra Reddy (Lubbock, Texas) |
| ABSTRACT | The present invention includes a method of inhibiting an activity of a BACE1 protein comprising contacting the BACE1 protein with a ligand that specifically inhibits residue Asp 32 of the human BACE1 protein. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/496921 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/222 (20130101) A61K 31/395 (20130101) A61K 31/473 (20130101) Original (OR) Class A61K 31/4015 (20130101) A61K 31/4196 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110937 | Dussor et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Greg Dussor (Dallas, Texas); Jacob E. Lackovic (Dallas, Texas) |
| ABSTRACT | The present disclosure provides a method of preventing, treating, or inhibiting migraine in a subject, by administering to the subject an amount of first therapeutic selected from cercosporamide, eFT508, or 4EGI-1 sufficient to prevent, treat, or inhibit said migraine. The present disclosure further provides a composition including at least two of cercosporamide. eFT508, or 4EGI-1, both in an amount sufficient to prevent, treat, or inhibit migraine in a subject and a pharmaceutically acceptable carrier. The present disclosure further provides a composition including at least one of cercosporamide, eFT508, or 4EGI-1 and at least one additional migraine therapeutic, both in an amount sufficient to prevent, treat, or inhibit migraine in a subject, and a pharmaceutically acceptable carrier. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/495902 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/05 (20130101) A61K 31/19 (20130101) A61K 31/167 (20130101) A61K 31/343 (20130101) A61K 31/426 (20130101) A61K 31/506 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110970 | Jhan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Yong-Yu Jhan (College Station, Texas); Corey J. Bishop (College Station, Texas); Guillermo Palou (College Station, Texas); Daniel Prasca-Chamorro (Cypress, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Yong-Yu Jhan (College Station, Texas); Corey J. Bishop (College Station, Texas); Guillermo Palou (College Station, Texas); Daniel Prasca-Chamorro (Cypress, Texas) |
| ABSTRACT | Provided herein is an engineered extracellular vesicle (eEV) and an extracellular vesicle delivery vehicle. The engineered extracellular vesicle is an isolated extracellular vesicle that has a membrane hybridized with lipids. The extracellular vesicle delivery vehicle is a lipid-hybridized extracellular vesicle with a nucleic acid loaded within the core, a multi-layered polyelectrolyte coating deposited around the lipid-hybridized extracellular vesicle and a therapeutic drug complexed to one of the layer of polyelectrolyte coatings. Also provided are methods for preparing an engineered extracellular vesicle, for preparing an extracellular vesicle delivery vehicle, for treating a pathophysiological condition in a subject, and for co-delivering a nucleic acid and a therapeutic drug to a cell of interest. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501759 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/12 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/543 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110980 | Halum |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Stacey L Halum (Indianapolis, Indiana) |
| ABSTRACT | This invention relates to a method for repairing and reconstructing a damaged or non-functional muscle, in particular to a method and a tool kit using in vitro primed motor endplate-expressing muscle progenitor cells (MPCs) to promote innervation of the damaged or non-functional muscle using an agent without any genetic manipulation. This method is particularly useful for repairing or reconstructing damaged or non-functional head and neck muscles, and urinary detrusor bladder muscle. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/552919 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/221 (20130101) A61K 35/30 (20130101) A61K 35/34 (20130101) Original (OR) Class A61K 38/1883 (20130101) A61K 2300/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) A61P 25/00 (20180101) A61P 43/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0658 (20130101) C12N 2501/805 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110981 | SADOWSKY et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Michael J. SADOWSKY (Roseville, Minnesota); Alexander KHORUTS (Golden Valley, Minnesota); Alexa R. WEINGARDEN (St. Paul, Minnesota); Matthew J. HAMILTON (Burnsville, Minnesota) |
| ABSTRACT | The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558094 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/16 (20130101) A61K 9/0053 (20130101) A61K 9/1617 (20130101) A61K 9/1623 (20130101) A61K 35/24 (20130101) A61K 35/37 (20130101) Original (OR) Class A61K 35/74 (20130101) A61K 35/741 (20130101) A61K 35/742 (20130101) A61K 45/06 (20130101) A61K 47/08 (20130101) A61K 47/26 (20130101) A61K 2035/11 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111010 | Lee et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seulki Lee (Baltimore, Maryland); Ted M. Dawson (Baltimore, Maryland); Han Seok Ko (Baltimore, Maryland); Valina L. Dawson (Baltimore, Maryland); Seung Pil Yun (Baltimore, Maryland); Magdalena Scully (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to compositions and methods for treating neurodegenerative conditions using GLP-1r agonists. In certain embodiments, long-acting GLP-1r agonists have neuroprotective and disease modifying effects on the central nervous system. |
| FILED | Monday, September 20, 2021 |
| APPL NO | 17/479428 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/26 (20130101) Original (OR) Class A61K 38/38 (20130101) A61K 47/60 (20170801) A61K 47/68 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/16 (20180101) A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111018 | Rowley et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Idaho (Moscow, Idaho) |
| ASSIGNEE(S) | University of Idaho (Moscow, Idaho) |
| INVENTOR(S) | Paul A. Rowley (Moscow, Idaho); Lance Fredericks (Garden City, Idaho); Angela M. Crabtree (Moscow, Idaho); Emily A. Kizer (Austin, Texas) |
| ABSTRACT | Killer toxins that may have activity against organisms, such as pathogenic organisms, and organisms that express the killer toxins are disclosed herein. The organism may be a recombinant organism or it may endogenously express a killer toxin. In some embodiments, a composition comprises one or more organisms, such as one or more Saccharomyces yeasts, and/or one or more killer toxins, such as K1, K2, and/or K1L toxins. In other embodiments, compositions comprise nucleic acids, vectors, host cells, or combinations thereof, comprising one or more killer toxins. Compositions can include one or more additional components, such as, but not limited to, a buffer, carrier, adjuvant, additional therapeutic, or combinations thereof. Kits that comprise one or more organisms and/or killer toxins are described. Uses of the organisms and/or killer toxins can include administration to a subject to treat an infection by one or more yeasts, such as Candida glabrata. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/555258 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0036 (20130101) A61K 36/064 (20130101) A61K 38/45 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111019 | KELLY et al. |
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| FUNDED BY |
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| APPLICANT(S) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (BLACKSBURG, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deborah F. KELLY (University Park, Pennsylvania); Yanping LIANG (Blacksburg, Virginia); William DEARNALEY (University Park, Pennsylvania) |
| ABSTRACT | Described herein are BRCA1 modulating compounds and formulations thereof. In some aspects, the BRCA1 modulating compound is a deubiquitinase. In some aspects, the BRCA1 modulating compound is a deubiquitinase inhibitor. as Also described herein are methods of treating a subject in need thereof with a BRCA1 modulating compound or formulation thereof. In some aspects, the subject in need thereof can have a cancer. In some aspects, the subject in need thereof has one or more BRCA1 mutations. |
| FILED | Thursday, September 19, 2019 |
| APPL NO | 17/278267 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 33/40 (20130101) A61K 38/48 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/485 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111039 | Yantasee et al. |
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| FUNDED BY |
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| APPLICANT(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| ASSIGNEE(S) | Oregon Health and Science University (Portland, Oregon); PDX Pharmaceuticals, Inc. (Portland, Oregon) |
| INVENTOR(S) | Wassana Yantasee (Lake Oswego, Oregon); Sherif Reda (Portland, Oregon); Moataz Reda (Portland, Oregon); Worapol Ngamcherdtrakul (Portland, Oregon); Ruijie Wang (Portland, Oregon) |
| ABSTRACT | Disclosed are immunogenic constructs including: a nanoparticle; a cationic polymer electrostatically bound to an exterior surface of the nanoparticle and a stabilizer bound to the cationic polymer or the exterior surface of the nanoparticle; and an antigen or antigen producing agent. Optionally, the constructs may include adjuvant and/or one or more functional oligonucleotide(s) (e.g., siRNA or pDNA). Also disclosed are methods of using the provided immunogenic constructs for co-delivering an adjuvant, antigen, and optionally siRNA to a cell, inducing immune response in a subject, and treating or preventing an infectious disease in a subject. |
| FILED | Wednesday, December 15, 2021 |
| APPL NO | 17/552331 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) Original (OR) Class A61K 2039/6093 (20130101) A61K 2039/55561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111060 | Spiegel et al. |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (NEW HAVEN, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Spiegel (New Haven, Connecticut); Patrick McEnaney (Jupiter, Florida); Kelly Fitzgerald (Upton, Massachusetts) |
| ABSTRACT | The present invention relates to compounds which function as antibody mimetic compounds. These compounds are bifuinctional/multifuinctional compounds which contain at least one cancer cell binding moiety which selectively binds to prostate specific membrane antigen (PSMA) and a FC receptor binding moiety which modulates an FC immune receptor, preferably a FcγRI receptor. Compounds according to the present invention bind selectively to cancer cells which upregulate PSMA and through that interaction, place the Fc receptor binding moiety of the compound in proximity to a Fc receptor, preferably a FcγRI receptor, which can modulate (preferably, upregulate) a humoral response in a patient to cancer cells. Through this biological action of the compounds according to the present invention, cancer cells, including metastatic cancer cells, especially prostate cancer cells can be immune regulated, resulting in the favorable therapy of cancer in a patient. Methods of using these compounds to treat cancer and/or reduce the likelihood of metastatis of cancer are additional aspects of the present invention. |
| FILED | Tuesday, December 15, 2020 |
| APPL NO | 17/122319 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/194 (20130101) A61K 38/10 (20130101) A61K 45/06 (20130101) A61K 47/54 (20170801) A61K 47/55 (20170801) Original (OR) Class Heterocyclic Compounds C07D 249/04 (20130101) C07D 249/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111068 | SHIN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (URBANA, Illinois) |
| INVENTOR(S) | JAE-WON SHIN (CHICAGO, Illinois); STEPHEN LENZINI (CHICAGO, Illinois) |
| ABSTRACT | Disclosed are recombinant extracellular vesicles (EVs), compositions including modified EVs encapsulated in a matrix, methods for controlling the release of EVs from an encapsulating matrix, and methods of using the same in the treatment of disease. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500423 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6903 (20170801) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111069 | Kosmides et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alyssa K. Kosmides (Balitmore, Maryland); Jonathan P. Schenck (Silver Spring, Maryland) |
| ABSTRACT | The presently disclosed subject matter relates to immunoswitch particles that switch off immunosuppressive pathways on tumor cells or immunosuppressive molecules induced by tumor cells in the tumor microenvironment, or virus infected cells or immunosuppressive molecules induced by virus infected cells in the microenvironment surrounding the virus infected cells, while simultaneously switching on co-stimulatory or co-inhibitory pathways on T cells, as well as method for converting immunosuppressive signals in cells, tissues, and subjects into stimulatory signals, and immunotherapy-based methods for treating cancer and chronic viral infections. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557886 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) A61K 9/0019 (20130101) A61K 9/5161 (20130101) A61K 39/395 (20130101) A61K 39/3955 (20130101) A61K 47/6849 (20170801) A61K 47/6873 (20170801) A61K 47/6939 (20170801) Original (OR) Class A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2827 (20130101) C07K 16/2878 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111080 | Schultz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| ASSIGNEE(S) | UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa) |
| INVENTOR(S) | Michael K. Schultz (Iowa City, Iowa); Frances L. Johnson (Iowa City, Iowa); Somya Kapoor (Iowa City, Iowa); Dongyoul Lee (Iowa City, Iowa); Mengshi Li (Iowa City, Iowa); Molly Martin (Iowa City, Iowa) |
| ABSTRACT | The invention provides compositions, kits and methods to treat a hyperproliferative disorder with an agent that increases expression of MCR1 and an MCR1 ligand. The invention also provides a method of treating drug-resistant melanoma, comprising administering an MCR1 ligand to a patient in need thereof. The present invention also provides in certain embodiments a melanoma-targeting conjugate comprising Formula I: T-L-X wherein T is a MCR1 ligand, L is a linker, and X an anti-cancer composition, for the therapeutic treatment of a hyperproliferative disorder. The present invention also provides methods, kits and uses of the conjugate of Formula I. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/507400 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/167 (20130101) A61K 31/192 (20130101) A61K 31/437 (20130101) A61K 31/519 (20130101) A61K 31/4427 (20130101) A61K 38/08 (20130101) A61K 47/60 (20170801) A61K 47/64 (20170801) A61K 47/545 (20170801) A61K 47/546 (20170801) A61K 51/048 (20130101) A61K 51/0482 (20130101) Original (OR) Class A61K 51/0497 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111094 | Castor |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trevor Percival Castor (Arlington, Massachusetts) |
| ASSIGNEE(S) | Trevor P. Castor (Woburn, Massachusetts) |
| INVENTOR(S) | Trevor Percival Castor (Arlington, Massachusetts) |
| ABSTRACT | The present invention is directed to methods and apparatus for pathogen decontamination of personal protective equipment (PPE), face filtering respiratory devices (FFR) and single use medical devices (SUD) by supercritical fluids, near critical fluids, and critical fluids with or without polar cosolvents. The invention includes a closed processing chamber for containing and processing the PPE, FFR, and SUD by a supercritical fluid, near critical fluid, and critical fluid with or without polar solvents at a specified temperature and pressure for a specified time sufficient to disrupt or inactivate pathogens and viruses on the PPE, FFR, and SUD without damaging the protective equipment so that they may be revitalized for continued use. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500908 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/18 (20130101) A61L 2/22 (20130101) Original (OR) Class A61L 2/24 (20130101) A61L 2/26 (20130101) A61L 2202/11 (20130101) A61L 2202/14 (20130101) A61L 2202/15 (20130101) A61L 2202/24 (20130101) A61L 2202/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111123 | ANNABI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nasim ANNABI (Los Angeles, California); Brian Walker (Los Angeles, California) |
| ABSTRACT | The present invention relates to adhesive and electroconductive cardiopatches designed to provide mechanical support and restore electromechanical coupling at the site of MI to minimize cardiac remodeling and preserve normal cardiac function. |
| FILED | Monday, April 13, 2020 |
| APPL NO | 17/602985 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/44 (20130101) Original (OR) Class A61L 27/58 (20130101) A61L 27/3687 (20130101) A61L 27/3695 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/0038 (20130101) Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 1/09 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 1/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111173 | Lautner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gergely Lautner (Ann Arbor, Michigan); Blake Stringer (Ypsilanti, Michigan); Elizabeth J. Brisbois (Athens, Georgia); Mark E. Meyerhoff (Ann Arbor, Michigan); Steven P. Schwendeman (Ann Arbor, Michigan) |
| ABSTRACT | Gas delivery devices include different examples of nitric oxide (NO) generating systems. Each example of the NO generating system includes a solid, light sensitive NO donor, and a light source that is operatively positioned to selectively expose the solid, light sensitive NO donor to light in order to generate NO gas. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 17/279448 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 15/0003 (20140204) A61M 16/0003 (20140204) A61M 16/12 (20130101) Original (OR) Class A61M 16/105 (20130101) A61M 2016/102 (20130101) A61M 2202/0275 (20130101) A61M 2205/587 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111175 | Mitchell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jennifer E. Mitchell (Elmer, New Jersey); Joseph R. Licwinko (Kenilworth, New Jersey); Thomas L. Merrill (Sewell, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer E. Mitchell (Elmer, New Jersey); Joseph R. Licwinko (Kenilworth, New Jersey); Thomas L. Merrill (Sewell, New Jersey) |
| ABSTRACT | A catheter has a lumen body having a distal end and a proximal end. A hub is connected to the proximal end. The hub includes a luer connection and a vacuum port assembly. |
| FILED | Thursday, January 17, 2019 |
| APPL NO | 16/250544 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 1/0058 (20130101) A61M 25/0054 (20130101) A61M 25/0074 (20130101) A61M 25/0097 (20130101) Original (OR) Class A61M 25/0133 (20130101) A61M 39/105 (20130101) A61M 2025/091 (20130101) A61M 2205/32 (20130101) A61M 2205/3633 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112164 | ZHOU et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jia ZHOU (Galveston, Texas); John A. ALLEN (Galveston, Texas); Pingyuan WANG (Galveston, Texas); Daniel E. FELSING (Galveston, Texas) |
| ABSTRACT | Embodiments are directed to novel GPR52 activators. In particular, a series of novel 1-(pyrimidin-4-yl)indoline-4-carboxamide analogs that have been identified as potent and selective GPR52 agonists. The optimized GPR52 agonist that, for example, can be used as a valuable pharmacological tool or a drug candidate for investigating the physiological and therapeutic potential of GPR52 activation for various human diseases. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499299 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/74 (20130101) Original (OR) Class C07D 401/04 (20130101) C07D 401/12 (20130101) C07D 403/04 (20130101) C07D 403/14 (20130101) C07D 405/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112166 | Jorgensen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William L. Jorgensen (Deep River, Connecticut); Joseph Schlessinger (Woodbridge, Connecticut) |
| ABSTRACT | The compounds of Formula I described herein regulate activity of JAK2 by specifically binding to the JAK2 pseudokinase domain, JH2, and are useful as therapeutic agents in the treatment or amelioration of myeloproliferative disorders. Also provided herein are methods of treating myeloproliferative disorders, and methods of making compounds of Formula I. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500622 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4196 (20130101) A61K 31/4245 (20130101) A61K 31/4439 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 249/14 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 405/12 (20130101) C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112178 | Ungashe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tosk, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Solomon B. Ungashe (Mountain View, California); Stephen D. Yanofsky (Mountain View, California) |
| ABSTRACT | RAS modulating compounds and methods of using the same are provided. The subject compounds comprise a core fused bicyclic group based on a quinoline-type scaffold having two fused six-membered aryl or heteroaryl rings, linked to a cyclic group (A) through the 2-position via a linker. The linked cyclic group can be an optionally substituted cyclopentyl or pyrrolidine group. The compounds find use in modulating the activity of a target RAS in a sample. The target RAS can be a mutant RAS that is implicated in a disease of interest. In some cases, the subject compounds can inhibit the growth of cancer cells whose progression is driven by kRAS or a mutated kRAS. Methods of treating a subject for a RAS driven disease including administering a therapeutically effective amount of the subject compound are provided. Also provided are pharmaceutical compositions and kits which include the subject compounds. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484735 |
| CURRENT CPC | Heterocyclic Compounds C07D 239/84 (20130101) C07D 401/10 (20130101) C07D 403/10 (20130101) C07D 403/12 (20130101) C07D 405/10 (20130101) Original (OR) Class C07D 413/10 (20130101) C07D 471/04 (20130101) C07D 491/056 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/99 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112179 | Huryn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); National Institutes of Health, A component of the United States Department of Health and Human Servi (Bethesda, Maryland); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania); National Institutes of Health, A Component of the United States Department of Health and Human Servi (Bethesda, Maryland); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Donna M. Huryn (Allentown, New Jersey); Peter Wipf (Pittsburgh, Pennsylvania); Matthew G. LaPorte (Pittsburgh, Pennsylvania); Raffaele Colombo (Pittsburgh, Pennsylvania); Marina Kovaliov (Pittsburgh, Pennsylvania); Chaemin Lim (Pittsburgh, Pennsylvania); Celeste Natalie Alverez (Pittsburgh, Pennsylvania); Zhizhou Yue (Pittsburgh, Pennsylvania); Lalith Palitha Samankumara (Pittsburgh, Pennsylvania); Alexander Julian Chatterley (Pittsburgh, Pennsylvania); Yongzhao Yan (Pittsburgh, Pennsylvania); Mary Liang (Pittsburgh, Pennsylvania); Neal J. Green (Newton, Massachusetts); Eric T. Baldwin (Upper Holland, Pennsylvania); William J. Moore (Hagerstown, Maryland); Michelle Arkin (San Francisco, California); R. Jeffrey Neitz (Oakland, California); Kean-Hooi Ang (Oakland, California); Clifford Bryant (Oakland, California); Stacie Bulfer (Oakland, California) |
| ABSTRACT | The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556147 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/10 (20130101) C07D 401/14 (20130101) C07D 405/14 (20130101) Original (OR) Class C07D 413/14 (20130101) C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112191 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Calla M. Olson (Brookline, Massachusetts); Yanke Liang (Brookline, Massachusetts); Nicholas Kwiatkowski (Auburn, Massachusetts) |
| ABSTRACT | The present application provides bifunctional compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for cyclin-dependent kinase 8 (CDK8). The present application also relates to methods for the targeted degradation of CDK8 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to CDK8 which can be utilized in the treatment of disorders modulated by CDK8. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561032 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/18 (20130101) A61K 47/545 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class C07D 471/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112205 | Ungashe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Tosk, Inc. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Solomon B. Ungashe (Mountain View, California); Stephen D. Yanofsky (Mountain View, California) |
| ABSTRACT | RAS modulating compounds and methods of using the same are provided. The compounds find use in modulating the activity of a target RAS in a sample. The target RAS can be a mutant RAS that is implicated in a disease of interest. In some cases, the subject compounds can inhibit the growth of cancer cells whose progression is driven by kRAS or a mutated kRAS. Methods of treating a subject for a RAS driven disease including administering a therapeutically effective amount of the subject compound are provided. Also provided are pharmaceutical compositions and kits which include the subject compounds. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484739 |
| CURRENT CPC | Heterocyclic Compounds C07D 239/84 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 405/10 (20130101) C07D 405/14 (20130101) C07D 471/04 (20130101) C07D 491/056 (20130101) Original (OR) Class C07D 519/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/99 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112218 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beibei Chen (Sewickley, Pennsylvania); Toren Finkel (Pittsburgh, Pennsylvania); Yuan Liu (Sewickley, Pennsylvania) |
| ABSTRACT | This document provides methods and materials for increasing TFEB polypeptide levels. For example, compounds (e.g., organic compounds) having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for increasing TFEB polypeptide levels within cells and/or within a nucleus of cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in TFEB polypeptide levels are provided. |
| FILED | Friday, January 03, 2020 |
| APPL NO | 17/420597 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Heterocyclic Compounds C07D 519/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112222 | Sato et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Noriko Sato (Potomac, Maryland); Haitao Wu (Rockville, Maryland); Gary L. Griffiths (North Potomac, Maryland); Peter L. Choyke (Rockville, Maryland) |
| ABSTRACT | The invention provides a method of preparing a 89Zr-oxine complex of the formula The invention also provides a method of labeling a cell with the 89Zr-oxine complex and a method for detecting a biological cell in a subject comprising administering the 89Zr-oxine complex to the subject. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532109 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0478 (20130101) A61K 51/1203 (20130101) General Methods of Organic Chemistry; Apparatus Therefor C07B 59/004 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/003 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/60 (20130101) G01N 2458/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112240 | HE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRANDEIS UNIVERSITY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongjian HE (Waltham, Massachusetts); Bing XU (Newton, Massachusetts) |
| ABSTRACT | The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/537418 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 35/00 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) C07K 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112251 | Sun |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xingmin Sun (Tampa, Florida) |
| ABSTRACT | Clostridium difficile, reclassified as Clostridioides difficile, is a Gram-positive, spore-forming, anaerobic, and toxin-producing nosocomial pathogen. Since the first description of a C. difficile-associated disease (CDAD)-like case in 1892, C. difficile infection (CDI) has become a high-impact health care-associated infection throughout the world, especially in the developed countries. Described herein are methods of treating Clostridium difficile infection in a subject in need thereof by administering an amount of the engineered lysin-human defensin (LHD) protein(s) described herein. |
| FILED | Monday, December 23, 2019 |
| APPL NO | 17/417587 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/005 (20130101) C07K 14/4723 (20130101) Original (OR) Class C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112262 | WEISS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael A. WEISS (Moreland Hills, Ohio) |
| ABSTRACT | A two-chain insulin analogue contains a modified A-chain polypeptide and a modified B-chain polypeptide. The A-chain polypeptide comprises one or more of: a His or Glu substitution at position A8, a Glu substitution at position A14; and a Gln or Arg substitution at position A17. The B-chain polypeptide comprises one or more of: a deletion of the amino acids at position B1, B1-B2, B1-B3, B30 or a combination thereof; an Ala or Glu substitution at position B2; a Glu substitution at position B3. The analogue exhibits thermodynamic stability in a zinc-free solution, decreased self-association, maintains biological potency, and no increased mitogenicity. The analogue exhibits resistance to chemical degradation and physical degradation. A method of treating a patient with diabetes mellitus or obesity comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. |
| FILED | Monday, December 27, 2021 |
| APPL NO | 17/562435 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Peptides C07K 14/62 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112269 | Raines et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald T. Raines (Madison, Wisconsin); Ismet Tanrikulu (Madison, Wisconsin) |
| ABSTRACT | Novel synthetic human scale collagen triple helices assemblies are disclosed. Methods of making self-assembling collagen mimetic peptides that self-assemble into human scale collagen are also disclosed. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554650 |
| CURRENT CPC | Peptides C07K 14/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112272 | Grakoui et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arash Grakoui (Decatur, Georgia); Joseph Marcotrigiano (New Brunswick, New Jersey) |
| ABSTRACT | The present disclosure relates to constructs useful in expressing biotinylated monomers and tetramers produced from these monomers. The present disclosure also relates to methods for production and use of these tetramers in identifying and isolating antigen specific B cells and cloning antibodies thereto. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557180 |
| CURRENT CPC | Peptides C07K 16/109 (20130101) Original (OR) Class C07K 16/1063 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1006 (20130101) C12N 2740/16122 (20130101) C12N 2770/24222 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112280 | HERING et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bernhard J. HERING (Minneapolis, Minnesota); Sabarinathan RAMACHANDRAN (Minneapolis, Minnesota) |
| ABSTRACT | The present disclosure is related to compositions and systems for inducing immune tolerance for transplanted cells, organ, or tissues in a transplant recipient. Also provided herein are methods of making and methods of administering tolerizing vaccines/regimen or preparatory regimens. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 16/241 (20130101) Original (OR) Class C07K 16/2866 (20130101) C07K 16/2878 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112459 | Meissner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Torsten B. Meissner (Somerville, Massachusetts); Leonardo M.R. Ferreira (San Francisco, California); Jack L. Strominger (Cambridge, Massachusetts); Chad A. Cowan (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic. |
| FILED | Saturday, October 09, 2021 |
| APPL NO | 17/497927 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0606 (20130101) Original (OR) Class C12N 5/0696 (20130101) C12N 15/86 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2501/50 (20130101) C12N 2501/599 (20130101) C12N 2501/998 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112469 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Boris PETERLIN (San Francisco, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Irene Chen (Los Angeles, California); Huan Peng (Los Angeles, California); Samuel Verbanic (Los Angeles, California) |
| ABSTRACT | Novel chimeric proteins may be used to inhibit transcriptional A activities that are mediated by transcription factor interactions with P-TEFb. The chimeras contain elements that recruit the target transcription factor, maintain CDK9 in an inactive state, and competitively inhibit P-TEFb binding to the transcription factor. The chimeras may be configured for inhibition of HIV Tat mediated transcription and thus provide a novel means of preventing reactivation of integrated HIV, providing a new tool for emerging “block and lock” HIV cure strategies. |
| FILED | Wednesday, October 02, 2019 |
| APPL NO | 17/280506 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 45/06 (20130101) A61K 47/6929 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/553 (20130101) G01N 33/54346 (20130101) G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112470 | CORNISH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Virginia W. CORNISH (New York, New York); Ehud HERBST (New York, New York) |
| ABSTRACT | The presently disclosed subject matter provides high-throughput assays, e.g., yeast three-hybrid assays, for detecting the presence of a molecule, e.g., therapeutic molecule. In certain embodiments, the presently disclosed subject matter provides genetically-engineered cells and assays for detecting tetracycline or derivatives thereof and kits for performing such assays. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556708 |
| CURRENT CPC | Peptides C07K 2319/71 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/003 (20130101) Original (OR) Class C12N 15/81 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Enzymes C12Y 105/01003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112504 | HOLT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | Jeffrey R. HOLT (Boston, Massachusetts); Bence GYORGY (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides compositions and methods for allele specific gene editing. In particular, the invention provides methods and compositions for treating dominant progressive hearing loss by selectively inactivating a dominant mutation in TMC1. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556463 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/86 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2320/34 (20130101) C12N 2330/51 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112519 | ZEMELMAN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Boris V. ZEMELMAN (Austin, Texas) |
| ABSTRACT | In some aspects, promoters, vectors, and methods of selectively inducing expression in subtypes of neuronal cells are provided. In some embodiments, single promoters can be used to restrict access to sub-populations of neurons. In some embodiments, single promoters active in different sub-populations of neurons can be used together to access a larger sub-population of neurons than either promoter alone (“set summation”). |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 17/431847 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) Original (OR) Class C12N 15/635 (20130101) C12N 2750/14143 (20130101) C12N 2830/001 (20130101) C12N 2830/008 (20130101) C12N 2830/48 (20130101) C12N 2830/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112542 | KHATRI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Purvesh KHATRI (Menlo Park, California); Aditya Manohar RAO (Stanford, California); David A. RELMAN (Palo Alto, California); Stephen POPPER (Stanford, California); Timothy E. SWEENEY (Redwood City, California) |
| ABSTRACT | This disclosure provides a gene expression-based method for determining whether a subject has a viral infection or a bacterial infection. A kit for performing the method is also provided. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/441670 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/686 (20130101) C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112544 | BERMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bio-Rad Laboratories, Inc. (Hercules, California); J. David Gladstone Institutes (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer BERMAN (San Carlos, California); Samantha COOPER (Berkeley, California); George KARLIN-NEUMANN (Palo Alto, California); Yuichiro MIYAOKA (San Francisco, California); Bruce CONKLIN (San Francisco, California); Josh SHINOFF (Emeryville, California) |
| ABSTRACT | Methods, compositions, and kits are provided for quantification of genome editing. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556118 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) C12N 15/102 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) C12Q 1/6827 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112552 | Ju et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| INVENTOR(S) | Jingyue Ju (Englewood Cliffs, New Jersey); Huanyan Cao (Changzhou City, China PRC); Zengmin Li (Flushing, New York); Qinglin Meng (Foster City, California); Jia Guo (Chandler, Arizona); Shenglong Zhang (Fort Lee, New Jersey); Lin Yu (New York, New York) |
| ABSTRACT | This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560928 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 19/06 (20130101) C07H 19/10 (20130101) C07H 19/14 (20130101) C07H 19/16 (20130101) C07H 19/20 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) Original (OR) Class C12Q 2525/301 (20130101) C12Q 2537/157 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112553 | Boyden et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); The Broad Institute, Inc. (Cambridge, Massachusetts) |
| INVENTOR(S) | Edward S. Boyden (Cambridge, Massachusetts); Fei Chen (Cambridge, Massachusetts); Nikita Obidin (Cambridge, Massachusetts); Andrew Colin Payne (Cambridge, Massachusetts) |
| ABSTRACT | Methods for single-molecule analysis of structure and sequence of linearized polynucleotides are provided. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500060 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6874 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112559 | Tan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Carolina (Columbia, South Carolina) |
| ASSIGNEE(S) | University of South Carolina (Columbia, South Carolina) |
| INVENTOR(S) | Wenbin Tan (Columbia, South Carolina); Elaine G. Taine (Columbia, South Carolina); Hui Wang (Wuhan City, China PRC); Vi Nguyen (Columbia, South Carolina); Xiaoling Cao (Columbia, South Carolina) |
| ABSTRACT | Described herein are methods and systems using ADAM30 as a biomarker to help early diagnosis of congenital malformed vasculatures in children and which can also serve as a companion diagnostic biomarker for malformed vasculatures, as well as a subpopulation of cancer cells, wherein blockage of activity of ADAM30 by a neutralized antibody or inhibitor can be used as a treatment strategy for those ADAM30-positive vascular endothelial cells and cancer cells. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400308 |
| CURRENT CPC | Peptides C07K 16/2896 (20130101) C07K 2317/76 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112566 | KENNEDY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (ROCHESTER, Minnesota) |
| ASSIGNEE(S) | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (ROCHESTER, Minnesota) |
| INVENTOR(S) | RICHARD B. KENNEDY (ROCHESTER, Minnesota); GREGORY A. POLAND (MARCO ISLAND, Florida); INNA G. OVSYANNIKOVA (ROCHESTER, Minnesota); IANA H. HARALAMBIEVA (ROCHESTER, Massachusetts) |
| ABSTRACT | This document provides methods and materials involved in using measles viruses. For example, methods and materials for identifying mammals (e.g., humans) likely to respond to standard measles virus vaccines or standard measles virus-based therapies as well as methods and materials for identifying mammals (e.g., humans) unlikely to respond to standard measles virus vaccines or standard measles virus-based therapies are provided. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557125 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/39 (20130101) A61K 39/165 (20130101) A61K 2039/575 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) A61P 31/14 (20180101) A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112567 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Genyan Yang (Tucker, Georgia); Charles Todd Davis (Decatur, Georgia) |
| ABSTRACT | Disclosed herein are methods for detecting presence of a target nucleic acid (such as an influenza virus nucleic acid) in a sample. In some embodiments, the methods include contacting the sample with a first probe capable of hybridizing to the target nucleic acid and a second probe capable of hybridizing to the target nucleic acid, contacting the resulting complex with one or more gap filling reagents, thereby producing a gap-filled target nucleic acid, isolating and amplifying the gap-filled target nucleic acid. The amplified gap-filled target nucleic acid covalently linked to the substrate is then detected, for example with a detectably labeled probe. Also disclosed herein are probes capable of hybridizing to influenza virus nucleic acids. The disclosure also includes kits for detecting and/or discriminating influenza virus nucleic acids in a sample. In some examples, the kits include two or more of the disclosed probes. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/555862 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/686 (20130101) C12Q 1/701 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 1/6816 (20130101) C12Q 2600/16 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) C12Q 2600/166 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113239 | Vacca et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kinetic River Corp. (Mountain View, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giacomo Vacca (Aptos, California); Ralph Jimenez (Boulder, Colorado) |
| ABSTRACT | Described herein are apparatuses and methods for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and quantifying a relative contribution of each component to the supercurve. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/559379 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/14 (20130101) Original (OR) Class G01N 15/147 (20130101) G01N 15/1429 (20130101) G01N 15/1434 (20130101) G01N 15/1436 (20130101) G01N 2015/144 (20130101) G01N 2015/149 (20130101) G01N 2015/1006 (20130101) G01N 2015/1438 (20130101) G01N 2015/1477 (20130101) G01N 2015/1488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113298 | Wellstein et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anton Wellstein (Washington, District of Columbia); Ghada M. Sharif (Washington, District of Columbia); Makarand Paranjape (Washington, District of Columbia); Leon Der (Washington, District of Columbia) |
| ABSTRACT | Systems and methods for characterizing cancer cells are disclosed. In certain embodiments, the systems and methods involve coating a first chamber with ECM material and adding a first plurality of cells to the first chamber, adding media to a second chamber, and adding a second plurality of cells and media to a third chamber. The first, second, and third chambers are then clipped together to form a chamber array. The chamber array is mounted to an electric cell impedance sensing reader and impedance readouts of cell invasion are collected from the electric array at time intervals. Cells detected to invade into the second chamber are extracted and characterized. |
| FILED | Monday, September 09, 2019 |
| APPL NO | 17/274128 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 23/20 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/02 (20130101) G01N 33/5005 (20130101) Original (OR) Class G01N 33/6851 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113311 | Altieri, I |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Dario C. Altieri, I (Philadelphia, Pennsylvania) |
| ABSTRACT | Therapeutic treatments of a tumor expressing pT346 PDK1, including glioma expressing pT346 PDK1, are disclosed. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561042 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2320/31 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) Original (OR) Class G01N 2333/91215 (20130101) G01N 2440/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113315 | Erstling et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Erstling (Ithaca, New York); Joshua A. Hinckley (Framingham, Massachusetts); Nirmalya Bag (Ithaca, New York); Ulrich B. Wiesner (Ithaca, New York) |
| ABSTRACT | Methods of obtaining and kits that can be used to obtain an optical super-resolution image of a sample or a portion thereof or an individual or a portion thereof. In various examples, the individual is an individual with cancer. In various examples, a method includes contacting a sample or individual with one or more aluminosilicate nanoparticle(s) that have at least one organic fluorophore molecule covalently bonded to the aluminosilicate network of the nanoparticle(s), or a composition including the aluminosilicate nanoparticle(s); irradiating the sample or the individual, thereby exciting at least one of the fluorophore molecules of an individual aluminosilicate nanoparticle; and obtaining a fluorescence image or a sequence of fluorescence images, which can be processed to obtain a super-resolution image of the sample or the individual. In various examples, the sample is a biological sample, living or fixed tissues and/or cells, or a biopsy obtained from an individual. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501854 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 21/6458 (20130101) G01N 33/587 (20130101) Original (OR) Class G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113316 | Tarca et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wayne State University (Detroit, Michigan); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | Wayne State University (Detroit, Michigan); The United States of America, as Represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Adi L. Tarca (South Lyon, Michigan); Piya Chaemsaithong (Shatin, China Hong Kong); Tinnakorn Chaiworapongsa (Grosse Pointe Park, Michigan); Sonia S. Hassan (Novi, Michigan); Roberto Romero (Grosse Pointe, Michigan) |
| ABSTRACT | Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558248 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/16 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/158 (20130101) Enzymes C12Y 304/24007 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/689 (20130101) Original (OR) Class G01N 2333/96494 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113321 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainsville, Florida); Banyan Biomarkers, Inc. (San Diego, California) |
| ASSIGNEE(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida); Banyan Biomarkers, Inc. (San Diego, California) |
| INVENTOR(S) | Kevin Ka-Wang WANG (Gainesville, Florida); Monika OLI (Gainesville, Florida); Ming-Cheng LIU (Gainesville, Florida) |
| ABSTRACT | The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/560144 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4064 (20130101) Peptides C07K 16/18 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/28 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220114733 | Feng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ruibin Feng (Scottsdale, Arizona); Zongwei Zhou (Tempe, Arizona); Jianming Liang (Scottsdale, Arizona) |
| ABSTRACT | Described herein are means for implementing contrastive learning via reconstruction within a self-supervised learning framework, in which the trained deep models are then utilized for the processing of medical imaging. For instance, an exemplary system is specially configured for performing a random cropping operation to crop a 3D cube from each of a plurality of medical images received at the system as input; performing a resize operation of the cropped 3D cubes; performing an image reconstruction operation of the resized and cropped 3D cubes to predict the whole image represented by the original medical images received; and generating a reconstructed image which is analyzed for reconstruction loss against the original image representing a known ground truth image to the reconstruction loss function. Other related embodiments are disclosed. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497528 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) Original (OR) Class G06T 7/0012 (20130101) G06T 2200/04 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20132 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115088 | Menche et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jörg Menche (Boston, Massachusetts); Albert-László Barabási (Boston, Massachusetts) |
| ABSTRACT | The present technology relates to methods that determine one or more subgroups of subjects within a population of subjects diagnosed with the same disease. In some embodiments, the methods include determining differential gene expression of at least one subgroup in the population using divisive Shuffling Approach (VIStA). In some embodiments, the method includes determining at least one clinical characteristic of each subgroup and/or determining a significant set of clinical characteristics of the disease order. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/485105 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) C12Q 1/6837 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 20/20 (20190201) Original (OR) Class G16B 25/00 (20190201) G16B 25/10 (20190201) G16B 40/00 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115143 | Baronov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Etiometry, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dimitar V. Baronov (Weston, Massachusetts); Michael F. McManus (Pembroke, Massachusetts) |
| ABSTRACT | Systems and methods produce a quantitative indication of the influence, on determination of a patient's clinical risk, of one or more measurements of one or more internal state variables. Illustrative embodiments compute a reference patient's clinical risk of being in a specific patient state using measurements of measurable internal state variables, and compute alternates of the same clinical risk using alternate values for at least one of the measurements of measurable internal state variables, and determine which of the measurements of internal state variables have the greatest quantitative impact on the patient's clinical risk by comparing the reference clinical risk to the alternate clinical risks. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501978 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 40/67 (20180101) G16H 50/30 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220116793 | Osinski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); AT and T Mobility II LLC (Atlanta, Georgia); Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); AT and T Mobility II LLC (Atlanta, Georgia); Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Matthew Osinski (Westfield, New Jersey); JIA WANG (Basking Ridge, New Jersey); Zihui Ge (Madison, New Jersey); Anthony Caracciolo (E.Brunswick, New Jersey); Chandra Thompson (College Park, Georgia); Benjamin Grizzle (Yukon, Oklahoma); Eric Bonitz (Pueblo, Colorado); Hendrik Hofman (Danville, California); Sonia Fahmy (West Lafayette, Indiana); Chunyi Peng (West Lafayette, Indiana); Bruno Ribeiro (West Lafayette, Indiana); Amit Kumar Sheoran (West Lafayette, Indiana) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, automatically detecting a service issue of a telecommunication system that may impact a customer of a telecommunication service provider of the telecommunication system, predicting, by the processing system, a future customer care interaction by the customer as a result of the service issue, initiating a resolution action of the telecommunication system for the service issue before the customer contacts a customer care agent of the telecommunication service provider, wherein the initiating is responsive to the predicting the future customer care interaction and modifying a component of the telecommunication system to improve efficiency of operation of the telecommunication system by reducing a number of customer care contacts by customers of the telecommunication service provider. Other embodiments are disclosed. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/066778 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/016 (20130101) Telephonic Communication H04M 3/4217 (20130101) H04M 3/5175 (20130101) H04M 15/886 (20130101) Wireless Communication Networks H04W 8/18 (20130101) H04W 24/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220110411 | Gusenoff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey A. Gusenoff (Pittsburgh, Pennsylvania); Beth R. Gusenoff (Pittsburgh, Pennsylvania); Steven Regis Donahoe (Pittsburgh, Pennsylvania) |
| ABSTRACT | An insole for offloading injuries on an area of a plantar surface of a patient's foot includes a body having a shape corresponding to the plantar surface of the patient's foot including a top surface and a bottom surface; and at least one supportive, deformable, deflatable bubble chamber. The at least one bubble chamber extends from the top surface of the body. The at least one bubble chamber is configured to be deflated to relieve pressure on the plantar surface of the patient's foot. A kit including the insole and an article of footwear including a sole, an upper connected about a periphery of the sole defining an interior of the article of footwear, and the insole positioned in the interior of the article, are also provided. |
| FILED | Friday, September 20, 2019 |
| APPL NO | 17/277916 |
| CURRENT CPC | Characteristic Features of Footwear; Parts of Footwear A43B 7/142 (20130101) A43B 7/144 (20130101) A43B 7/1445 (20130101) A43B 17/03 (20130101) Original (OR) Class A43B 17/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110573 | Makeyev |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Diné College (Tsaile, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Oleksandr Makeyev (Tsaile, Arizona) |
| ABSTRACT | An electrode device for electrophysiological measurement may include an electrode substrate having a surface area. The electrode device may include a central electrode disposed on the electrode substrate around a central portion of the surface area. The electrode device may include a plurality of electrodes disposed on the electrode substrate concentric with the central electrode. The plurality of electrodes may include a first electrode covering a first portion of the surface area of the electrode substrate and a second electrode covering a second portion of the surface area of the electrode substrate. The second portion may be greater than a combined surface area of the first portion and the central portion. |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353095 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/291 (20210101) Original (OR) Class A61B 2562/04 (20130101) A61B 2562/0209 (20130101) A61B 2562/0215 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110619 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xuanhe Zhao (Allston, Massachusetts); Hyunwoo Yuk (Cambridge, Massachusetts); Sarah J Wu (Cambridge, Massachusetts); Christoph Nabzdyk (Rochester, Minnesota) |
| ABSTRACT | Bioadhesive materials and methods for adhering biological tissues and blood vessels in a minimally invasive manner, wherein the bioadhesive materials are in folded bioadhesive sleeve configurations or in injectable bioadhesive forms adapted for delivery using minimally invasive procedures. The folded bioadhesive sleeve is disposed on the distal portions of a variety of minimally invasive devices for insertion to a target tissue site, then deployed and adhered to the target tissue site through actuation of the minimally invasive device. The injectable bioadhesive is disposed in a syringe and delivered to a target site via a catheter, then adhered to the target tissue by actuation of a minimally invasive device. Precise placement and adhesion to the target tissue site can be successfully accomplished solely through the actuation of the minimally invasive devices without the use of additional devices to assist in placement or actuation of the bioadhesive materials. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497497 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00491 (20130101) Original (OR) Class A61B 17/07292 (20130101) A61B 2017/00526 (20130101) A61B 2017/00938 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/06 (20130101) A61L 2400/06 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110728 | Weitekamp et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | POLYSPECTRA, INC. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond A. Weitekamp (Berkeley, California); Aditya Balasubramanian (Berkeley, California) |
| ABSTRACT | Described herein are compositions and methods for generating dental products or orthodontic products. The compositions and methods comprise latent ruthenium complexes and photoacids and/or photoacid generators. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399368 |
| CURRENT CPC | Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 13/0019 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 6/62 (20200101) A61K 6/887 (20200101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/35 (20170801) B29C 64/124 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/753 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110931 | Reddy |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | P. Hemachandra Reddy (Lubbock, Texas) |
| ABSTRACT | The present invention includes a method of inhibiting an activity of a BACE1 protein comprising contacting the BACE1 protein with a ligand that specifically inhibits residue Asp 32 of the human BACE1 protein. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/496921 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/222 (20130101) A61K 31/395 (20130101) A61K 31/473 (20130101) Original (OR) Class A61K 31/4015 (20130101) A61K 31/4196 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111018 | Rowley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Idaho (Moscow, Idaho) |
| ASSIGNEE(S) | University of Idaho (Moscow, Idaho) |
| INVENTOR(S) | Paul A. Rowley (Moscow, Idaho); Lance Fredericks (Garden City, Idaho); Angela M. Crabtree (Moscow, Idaho); Emily A. Kizer (Austin, Texas) |
| ABSTRACT | Killer toxins that may have activity against organisms, such as pathogenic organisms, and organisms that express the killer toxins are disclosed herein. The organism may be a recombinant organism or it may endogenously express a killer toxin. In some embodiments, a composition comprises one or more organisms, such as one or more Saccharomyces yeasts, and/or one or more killer toxins, such as K1, K2, and/or K1L toxins. In other embodiments, compositions comprise nucleic acids, vectors, host cells, or combinations thereof, comprising one or more killer toxins. Compositions can include one or more additional components, such as, but not limited to, a buffer, carrier, adjuvant, additional therapeutic, or combinations thereof. Kits that comprise one or more organisms and/or killer toxins are described. Uses of the organisms and/or killer toxins can include administration to a subject to treat an infection by one or more yeasts, such as Candida glabrata. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/555258 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0036 (20130101) A61K 36/064 (20130101) A61K 38/45 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111069 | Kosmides et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alyssa K. Kosmides (Balitmore, Maryland); Jonathan P. Schenck (Silver Spring, Maryland) |
| ABSTRACT | The presently disclosed subject matter relates to immunoswitch particles that switch off immunosuppressive pathways on tumor cells or immunosuppressive molecules induced by tumor cells in the tumor microenvironment, or virus infected cells or immunosuppressive molecules induced by virus infected cells in the microenvironment surrounding the virus infected cells, while simultaneously switching on co-stimulatory or co-inhibitory pathways on T cells, as well as method for converting immunosuppressive signals in cells, tissues, and subjects into stimulatory signals, and immunotherapy-based methods for treating cancer and chronic viral infections. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557886 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) A61K 9/0019 (20130101) A61K 9/5161 (20130101) A61K 39/395 (20130101) A61K 39/3955 (20130101) A61K 47/6849 (20170801) A61K 47/6873 (20170801) A61K 47/6939 (20170801) Original (OR) Class A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2827 (20130101) C07K 16/2878 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111249 | Brown et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Texas System (Austin, Texas); The University of Alabama (Tuscaloosa, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Brown (Galveston, Texas); Chih-Ying Li (Galveston, Texas); Mansoo Ko (Galveston, Texas); Shengting Cao (Tuscaloosa, Alabama); Xuefeng Wang (Tuscaloosa, Alabama); Fei Hu (Tuscaloosa, Alabama); Yu Gan (Tuscaloosa, Alabama); Liang Zhang (Tuscaloosa, Alabama) |
| ABSTRACT | The present disclosure presents improved treadmill control systems and methods. One such method comprises initiating a recording a video sequence of a walking exercise by a subject on a treadmill device; extracting intra-gait phases of the subject from the recorded video sequence using a video temporal alignment with a neural network; generating a series of treadmill belt control settings for the treadmill device corresponding to each phase of the gait pattern of the subject; and signaling the series of treadmill belt control settings to a motor controller of the treadmill device. Other methods and systems are also provided. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/498986 |
| CURRENT CPC | Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 22/025 (20151001) Original (OR) Class A63B 24/0003 (20130101) A63B 24/0087 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111348 | Shi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MyTide Therapeutics, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Shi (Boston, Massachusetts); Liudi Yang (Franklin, Massachusetts) |
| ABSTRACT | The present disclosure provides computer-based methods and systems for controlling peptide synthesis. An embodiment begins by providing a manufacturing process that synthesizes peptides using solid phase slug flow. In turn, the manufacturing process is automated through use of a machine learning engine by selecting values for operating conditions for the manufacturing process. In such an embodiment, a given operating condition is flow rate profile. An embodiment generates an indication of the selected values for the operating conditions and controls the manufacturing process therewith. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/535210 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) Original (OR) Class B01J 2219/0059 (20130101) B01J 2219/00286 (20130101) B01J 2219/00423 (20130101) B01J 2219/00596 (20130101) B01J 2219/00689 (20130101) B01J 2219/00695 (20130101) Peptides C07K 1/042 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111353 | Petruska et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Melissa A. Petruska (Newtown, Connecticut); Jeffrey F. Roeder (Brookfield, Connecticut); Trevor E. James (Plantsville, Connecticut); Peter C. Van Burkirk (Newtown, Connecticut); Thomas S. Spoonmore (Norwalk, Connecticut); Robert T. Henderson, III (New Milford, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa A. Petruska (Newtown, Connecticut); Jeffrey F. Roeder (Brookfield, Connecticut); Trevor E. James (Plantsville, Connecticut); Peter C. Van Burkirk (Newtown, Connecticut); Thomas S. Spoonmore (Norwalk, Connecticut); Robert T. Henderson, III (New Milford, Connecticut) |
| ABSTRACT | Monolithic composite photocatalysts for fluid purification are disclosed. The monolithic composite photocatalysts comprise a photoactive nanocrystal component and a non-photoactive porous support. Photocatalytic fluid purification systems that contact an impurity-containing fluid with the subject monolithic composite photocatalysts are also disclosed. The monolithic composite photocatalysts may be affixed to or embedded in scaffold structures to promote fluid flow through a fluid purification system and contact with the monolithic composite photocatalysts. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/481279 |
| CURRENT CPC | Separation B01D 53/865 (20130101) B01D 53/8687 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/063 (20130101) Original (OR) Class B01J 35/004 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/50 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111359 | Miller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| INVENTOR(S) | Jeffrey T. Miller (West Lafayette, Indiana); Zhenwei Wu (West Lafayette, Indiana); Evan C. Wegener (West Lafayette, Indiana); Stephen Purdy (West Lafayette, Indiana); Nicole J. Libretto (West Lafayette, Indiana) |
| ABSTRACT | A novel catalyst composition and its use in the dehydrogenation of alkanes to olefins. The catalyst comprises a Group VIII noble metal and a metal selected from the group consisting of manganese, vanadium, chromium, titanium, and combinations thereof, on a support. The Group VIII noble metal can be platinum, palladium, osmium, rhodium, rubidium, iridium, and combinations thereof. The support can be silicon dioxide, titanium dioxide, aluminum oxide, silica-alumina, cerium dioxide, zirconium dioxide, magnesium oxide, metal modified silica, silica-pillared clays, silica-pillared micas, metal oxide modified silica-pillared mica, silica-pillared tetrasilicic mica, silica-pillared taeniolite, zeolite, molecular sieve, and combinations thereof. The catalyst composition is an active and selective catalyst for the catalytic dehydrogenation of alkanes to olefins. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556804 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/02 (20130101) B01J 21/063 (20130101) B01J 23/6482 (20130101) Original (OR) Class B01J 23/6522 (20130101) B01J 23/6562 (20130101) B01J 37/08 (20130101) B01J 37/16 (20130101) Acyclic or Carbocyclic Compounds C07C 5/3337 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111386 | Anand et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robbyn K. Anand (Ames, Iowa); Sungu Kim (Ames, Iowa); Baskar Ganapathysubramanian (Ames, Iowa) |
| ABSTRACT | Microfluidic devices and methods that utilize ion concentration polarization within water-in-oil nanoliter scale droplets for concentration enrichment, separation, and substitution of charges species are disclosed. Such devices and methods can be used for separation of multiple species by mobility of each species and for the alteration and manipulation of the droplet composition by ion exchange. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/450931 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) B01L 3/502707 (20130101) B01L 3/502715 (20130101) B01L 3/502792 (20130101) Original (OR) Class B01L 2200/12 (20130101) B01L 2200/16 (20130101) B01L 2200/0673 (20130101) B01L 2200/0689 (20130101) B01L 2300/12 (20130101) B01L 2300/0645 (20130101) B01L 2300/0681 (20130101) B01L 2300/0896 (20130101) B01L 2400/0421 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112240 | HE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BRANDEIS UNIVERSITY (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hongjian HE (Waltham, Massachusetts); Bing XU (Newton, Massachusetts) |
| ABSTRACT | The present invention relates to a branched peptide that includes a first peptide chain and a second peptide chain having its C-terminal amino acid covalently linked to a sidechain of an amino acid residue of the first peptide chain, wherein the first peptide chain includes a plurality of aromatic amino acids and, optionally, an aromatic group linked to an amino terminus of the first peptide chain; and the second peptide chain includes a plurality of hydrophilic amino acids and an enzyme cleavage site. Pharmaceutical compositions containing the branched peptide and one or more therapeutic agents in an aqueous medium are disclosed, where the branched peptides form micelle structures in the aqueous medium. Methods of using the pharmaceutical composition to deliver therapeutic agents, and for treating various disease conditions are also described. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/537418 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) A61P 35/00 (20180101) Peptides C07K 7/06 (20130101) Original (OR) Class C07K 7/08 (20130101) C07K 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112339 | Subramaniam et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bala Subramaniam (Lawrence, Kansas); Julian R. Silverman (Nyack, New York); Andrew M. Danby (East Yorkshire, United Kingdom); Thomas Binder (Marion, Iowa); Steffan Green (Lawrence, Kansas) |
| ABSTRACT | Methods of forming lignin prepolymers are provided. In an embodiment, such a method comprises adding an acid to an ozonized reaction mixture, the ozonized reaction mixture comprising ozonized lignin having a backbone, and aromatic monomers cleaved from a lignin, under conditions to react the cleaved aromatic monomers with the backbone of the ozonized lignin to form a lignin prepolymer. The methods may further comprise using the lignin prepolymer to form a lignin resin. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554056 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/00 (20130101) Original (OR) Class C08J 2397/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112381 | HUNT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heather HUNT (Columbia, Missouri); Azlin MUSTAPHA (Columbia, Missouri); Eduardo Torres DOMINQUEZ (Columbia, Missouri) |
| ABSTRACT | The present application relates to an antimicrobial coated substrate with one or more surfaces and a TiO2 coating on at least one of the surfaces of the substrate, where the coating has a rhombohedral microstructure. Also disclosed is a process for preparing an antimicrobial coated substrate with one or more surfaces and methods of killing microbes. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499374 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 59/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112464 | Strobel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Advanced Solutions Life Sciences, LLC (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hannah A. Strobel (Manchester, New Hampshire); James B. Hoying (Manchester, New Hampshire) |
| ABSTRACT | A method for producing a functional, vascularized organoid or spheroid is provided, the method including: (a) mixing a suspension of stromal cells with microvessel (MV) fragments isolated from adipose tissue to provide an MV/stromal cell suspension; and (b) culturing the MV/stromal cell suspension in an angiogenic medium to provide the functional, vascularized organoid or spheroid. Also provided is a method for producing a functional, vascularized adipocyte organoid or spheroid and a method of screening compounds for pharmacological or toxicological activity, using the vascularized organoids and/or spheroids provided herein. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497364 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0653 (20130101) Original (OR) Class C12N 2501/33 (20130101) C12N 2501/165 (20130101) C12N 2501/999 (20130101) C12N 2506/1353 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5014 (20130101) G01N 33/5082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112510 | Gelvin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayetter, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayetter, Indiana) |
| INVENTOR(S) | Stanton B Gelvin (West Lafayette, Indiana); Lan-Ying Lee (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure provides a series of mutant Agrobacterium strains generated by random mutagenesis of a wide-type or ω mutant VirD2 gene or VirD2 protein. The mutant Agrobacterium strains of the present disclosure transiently express T-DNA-encoded transgenes in a target plant but do not stably integrate these genes into the plant genome. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/494977 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 15/743 (20130101) C12N 15/8205 (20130101) Original (OR) Class C12N 15/8213 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112524 | Arnold et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frances Arnold (Pasadena, California); Peter Meinhold (Pasadena, California); Matthew W. Peters (Pasadena, California); Rudi Fasan (Brea, California); Mike M.Y. Chen (Pasadena, California) |
| ABSTRACT | This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560753 |
| CURRENT CPC | Peptides C07K 14/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0042 (20130101) C12N 9/0071 (20130101) C12N 9/0077 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) Original (OR) Class C12P 7/06 (20130101) Enzymes C12Y 106/02004 (20130101) C12Y 114/15 (20130101) C12Y 114/14001 (20130101) C12Y 114/15003 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/52 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112546 | Martin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig Martin (Amherst, Massachusetts); Elvan Cavac (Northampton, Massachusetts); Kithmie Harshana Malagodapathiranage (Amherst, Massachusetts) |
| ABSTRACT | Described herein are synthetic methods for producing sequence-specific RNA oligonucleotides that eliminate impurities produced in prior art methods. In one aspect, a first amplification primer includes one or more deoxyuridine residues, wherein at least one of the one or more deoxyuridine residues is at position −1, −2, −3, −4 or −5 of the promoter region for the single-subunit, DNA-dependent RNA polymerase. The deoxyuridines are excised to provide an amplified functional template DNA which is then used to synthesize RNA which has reduced immunogenic double stranded RNA compared to controls. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/512975 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6848 (20130101) Original (OR) Class C12Q 1/6853 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112582 | Anasori et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Babak Anasori (Fishers, Indiana); Weichen Hong (Indianapolis, Indiana) |
| ABSTRACT | A composition of matter defined by the general formula of M2+vL1−vX2, wherein: X is carbon; M represents a transition metal selected from the group consisting of Ti, Ta, Sc, Cr, Zr, Mo, V, and Nb; and L represents a lanthanide element selected from the group consisting of Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497003 |
| CURRENT CPC | Alloys C22C 1/06 (20130101) C22C 1/051 (20130101) C22C 1/058 (20130101) C22C 29/02 (20130101) Original (OR) Class C22C 2202/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112654 | Aminu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Temitope Q. Aminu (Beaverton, Oregon); David Frederick Bahr (West Lafayette, Indiana) |
| ABSTRACT | Systems and methods are provided that entail polymeric fibers produced via an electrospinning process, and metallic nanostructures adhered to surfaces of the polymeric fibers via an electroless deposition process. Suitable materials for the polymeric fibers and metallic nanostructures include polyacrylonitrile (PAN) fibers and copper nanostructures, respectively. |
| FILED | Friday, August 06, 2021 |
| APPL NO | 17/395746 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 18/38 (20130101) C23C 18/1641 (20130101) C23C 18/1646 (20130101) C23C 18/2053 (20130101) Making Textile Fabrics, e.g From Fibres or Filamentary Material; Fabrics Made by Such Processes or Apparatus, e.g Felts, Non-woven Fabrics; Cotton-wool; Wadding D04H 1/43 (20130101) D04H 1/74 (20130101) D04H 1/728 (20130101) Treatment, Not Provided for Elsewhere in Class D06, of Fibres, Threads, Yarns, Fabrics, Feathers or Fibrous Goods Made From Such Materials D06M 11/83 (20130101) Original (OR) Class D06M 2101/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113247 | WOLF et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | GEORGETOWN UNIVERSITY (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian WOLF (Arlington, Virginia); Zeus A. O. DE LOS SANTOS (Washington, District of Columbia); Ciaran LYNCH (Washington, District of Columbia) |
| ABSTRACT | The present invention relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, and providing a probe selected from the group consisting of metal salts. The sample is contacted with the probe under conditions that permit coordination of the probe to the analyte, if present in the sample; and, based on any coordination that occurs, the absolute configuration of the analyte in the sample, and/or the concentration of the analyte in the sample, and/or the enantiomeric composition of the analyte in the sample is/are determined. |
| FILED | Wednesday, September 11, 2019 |
| APPL NO | 17/275471 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/19 (20130101) Original (OR) Class G01N 21/77 (20130101) G01N 2021/7786 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113287 | Mohana Rangan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Srivatsan Mohana Rangan (Tempe, Arizona); Anca Delgado (Tempe, Arizona); Rosa Krajmalnik-Brown (Chandler, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Srivatsan Mohana Rangan (Tempe, Arizona); Anca Delgado (Tempe, Arizona); Rosa Krajmalnik-Brown (Chandler, Arizona) |
| ABSTRACT | Methods and systems for the detection and quantification of multiplicity of ionic analytes comprising CrO42−, AsO43−, SeO42−, and ClO4−, and optionally F−, Cl−, NO2−, NO3−, SO42−, using ion chromatography and suppressed ion conductivity. The method comprises loading a sample loop with a sample; injecting the sample from the sample loop into a column with an eluent, wherein the column comprises a guard column and an analytical column; separating, with the column, the injected sample at an effective separation temperature the injected sample in the presence of an organic modifier into a multiplicity of detectable ionic analytes; suppressing, with a suppressor, background signal; and detecting, with a detector, the multiplicity of ionic analytes. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498203 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 30/54 (20130101) Original (OR) Class G01N 30/64 (20130101) G01N 30/8679 (20130101) G01N 33/182 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113975 | Lucia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brandon Lucia (Pittsburgh, Pennsylvania); Nathan Beckmann (Pittsburgh, Pennsylvania); Graham Gobieski (Pittsburgh, Pennsylvania) |
| ABSTRACT | Disclosed herein is a highly energy-efficient architecture targeting the ultra-low-power sensor domain. The architecture achieves high energy-efficiency while maintaining programmability and generality. The invention introduces vector-dataflow execution, allowing the exploitation of the dataflows in a sequence of vector instructions and to amortize instruction fetch and decode over a whole vector of operations. The vector-dataflow architecture allows the invention to avoid costly vector register file accesses, thereby saving energy. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500017 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3802 (20130101) G06F 9/3838 (20130101) Original (OR) Class G06F 9/30036 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220114307 | Severson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan Severson (Lincoln, Nebraska); Prahalada Rao (Lincoln, Nebraska); Reza Yavari (Lincoln, Nebraska); Kevin D. Cole (Lincoln, Nebraska) |
| ABSTRACT | Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for an additive manufacturing heat transfer simulation. For example, an additive manufacturing heat transfer simulation system converts a model of an object into a node representation of the object, and generates a network graph of the object based on the node representation. For each block of nodes in the node representation the system applies a simulated heat to the block of nodes, estimates a diffusion of heat to other nodes based on the network graph, and estimates a heat loss to atmosphere. The system generates a representation of an estimated heat distribution within the object. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499402 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/20 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220114405 | Zhang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhongfei Zhang (Vestal, New York); Shuangfei Zhai (Binghamton, New York) |
| ABSTRACT | A method of modelling data, comprising: training an objective function of a linear classifier, based on a set of labeled data, to derive a set of classifier weights; defining a posterior probability distribution on the set of classifier weights of the linear classifier; approximating a marginalized loss function for an autoencoder as a Bregman divergence, based on the posterior probability distribution on the set of classifier weights learned from the linear classifier; and classifying unlabeled data using the autoencoder according to the marginalized loss function. |
| FILED | Sunday, December 19, 2021 |
| APPL NO | 17/555493 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6256 (20130101) G06K 9/6269 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/084 (20130101) G06N 3/0454 (20130101) G06N 3/0472 (20130101) G06N 7/005 (20130101) G06N 20/10 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220114498 | Woodbury |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Neal Woodbury (Tempe, Arizona) |
| ABSTRACT | Methods and systems, including those employing machine learning, utilizing one or more algorithms for relating the structure of a molecule in a library to its function are described. Embodiments described herein relate structure to function by considering the covalent structure of the molecule, the components of that structure that are common to many molecules in the library, and the properties of those components as they relate to the function in question. Applications include, for example, enhancement and amplification of the diagnostic and prognostic signals provided by peptide arrays for use in analyzing the profile of antibodies in the blood produced in response to a disease, condition or treatment. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/510517 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 20/10 (20190101) Original (OR) Class Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115223 | BELMONT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WYOMING (Laramie, Wyoming) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erica BELMONT (Laramie, Wyoming); Franco BASILE (Fort Collins, Colorado); James RUNDEL (Laramie, Wyoming); Andrew GOODENOUGH (Laramie, Wyoming) |
| ABSTRACT | A method and apparatus for monitoring and/or controlling the extent of denaturation and/or bond cleavages of proteins on any surface (e.g., biological tissues, biofilms, etc.). In one embodiment, a low power laser (e.g., a 5 mW, 362 nm diode laser) is directed through a biological sample to a photodetector. The sample is heated by a set of radiant heaters to between about 220° C. and about 250° C. in a time period of between 10 seconds to 60 seconds. The baseline transmissivity of the sample is monitored continuously throughout treatment of the biological sample via continuous monitoring of the signal voltage detected at the photodetector. Upon detection of increase in relative transmissivity in the biological sample, the heating treatment is concluded and the biological sample is removed for in situ protein identification as part of an imaging MALDI-MS measurement. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556349 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/0004 (20130101) H01J 49/164 (20130101) H01J 49/0418 (20130101) Original (OR) Class H01J 49/0459 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115551 | Kostuk et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond K. Kostuk (Tucson, Arizona); Benjamin Chrysler (Tucson, Arizona); Xuesen Tan (Tucson, Arizona) |
| ABSTRACT | A photovoltaic module comprises one or more spectrum splitting devices disposed adjacent a first side of the photovoltaic module; and a plurality of photovoltaic cells disposed adjacent a second side of the photovoltaic module opposite the first side and such that the photovoltaic cells are spaced from the one or more spectrum splitting devices, wherein at least one of the photovoltaic cells comprise a bifacial photovoltaic cell, wherein the one or more spectrum splitting devices are configured to selectively direct incident energy to one or more of the photovoltaic cells, and wherein a spatial configuration of the one or more spectrum splitting devices and the plurality of photovoltaic cells are configured based on an optimization parameter. |
| FILED | Wednesday, April 15, 2020 |
| APPL NO | 17/602975 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0549 (20141201) Original (OR) Class H01L 31/0684 (20130101) H01L 31/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220116441 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yao Liu (Vestal, New York); Shuoqian Wang (Vestal, New York) |
| ABSTRACT | SphericRTC provides real-time 360-degree video communication, which allows the viewer to observe the environment in any direction from the camera location. This more allows users to more-efficiently exchange information and can be beneficial in the real-time setting. The system selects representations of 360-degree frames to allow efficient, content-adaptive delivery. The system performs joint content and bitrate adaptation in real-time by offloading expensive transformation operations to a GPU. The system demonstrates that the multiple sub-components: viewport feedback, representation selection, and joint content and bitrate adaptation, can be effectively integrated within a single framework. Compared to a baseline implementation, views in SphericRTC have consistently higher visual quality. The median Viewport-PSNR of such views is 2.25 dB higher than views in the baseline system. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/449893 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 65/601 (20130101) Original (OR) Class H04L 65/608 (20130101) Pictorial Communication, e.g Television H04N 5/23238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220116789 | BERTIZZOLO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lorenzo BERTIZZOLO (Boston, Massachusetts); Tommaso MELODIA (Newton, Massachusetts) |
| ABSTRACT | Method and systems of sharing a frequency spectrum between a primary wireless network and a secondary wireless network coexisting with the primary wireless network are provided. At a node of the secondary network, at a bottom of a protocol stack integrated between a plurality of antennas and upper layers of the protocol stack, a beamforming scheme is determined for transmission to scheduled users of the secondary network. Using this technology, a newly-deployed wireless network can access a spectrum band based on cognitive beamforming without mutual temporal exclusion, i.e., without interrupting the ongoing transmissions of coexisting wireless networks on the same bands, and without cross-technology communication. |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 17/431752 |
| CURRENT CPC | Transmission H04B 7/0456 (20130101) H04B 7/0617 (20130101) H04B 7/0626 (20130101) H04B 7/0689 (20130101) Wireless Communication Networks H04W 16/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220116793 | Osinski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); AT and T Mobility II LLC (Atlanta, Georgia); Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); AT and T Mobility II LLC (Atlanta, Georgia); Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Matthew Osinski (Westfield, New Jersey); JIA WANG (Basking Ridge, New Jersey); Zihui Ge (Madison, New Jersey); Anthony Caracciolo (E.Brunswick, New Jersey); Chandra Thompson (College Park, Georgia); Benjamin Grizzle (Yukon, Oklahoma); Eric Bonitz (Pueblo, Colorado); Hendrik Hofman (Danville, California); Sonia Fahmy (West Lafayette, Indiana); Chunyi Peng (West Lafayette, Indiana); Bruno Ribeiro (West Lafayette, Indiana); Amit Kumar Sheoran (West Lafayette, Indiana) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, automatically detecting a service issue of a telecommunication system that may impact a customer of a telecommunication service provider of the telecommunication system, predicting, by the processing system, a future customer care interaction by the customer as a result of the service issue, initiating a resolution action of the telecommunication system for the service issue before the customer contacts a customer care agent of the telecommunication service provider, wherein the initiating is responsive to the predicting the future customer care interaction and modifying a component of the telecommunication system to improve efficiency of operation of the telecommunication system by reducing a number of customer care contacts by customers of the telecommunication service provider. Other embodiments are disclosed. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/066778 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/016 (20130101) Telephonic Communication H04M 3/4217 (20130101) H04M 3/5175 (20130101) H04M 15/886 (20130101) Wireless Communication Networks H04W 8/18 (20130101) H04W 24/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220110393 | Isherwood et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | U.S. Government as Represented by the Secretary of the Army (Natick, Massachusetts) |
| ASSIGNEE(S) | U.S. Government as Represented by the Secretary of the Army (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Kristine Drobot Isherwood (Boston, Massachusetts); Ashley N. Cushon (Natick, Massachusetts); Chong Whitfield (Natick, Massachusetts) |
| ABSTRACT | A garment assembly has a left sleeve member, a right sleeve member and a fastener member connecting the left sleeve member and the right sleeve member together across a front portion of the garment. A shaped hem member connects the left sleeve member and the right sleeve member across a back portion of the garment. One end the shaped hem member is secured to one side of the fastener member and an other end of the shaped hem member is secured to an other side of the fastener member. |
| FILED | Monday, June 03, 2019 |
| APPL NO | 16/429103 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 27/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110522 | Hu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Juejun Hu (Newton, Massachusetts); Tian GU (Fairfax, Virginia); Mikhail Shalaginov (Somerville, Massachusetts); Fan YANG (Cambridge, Massachusetts) |
| ABSTRACT | Meta-lens based ocular imaging, near-eye display, and eye-tracking systems are described. The systems can include a single focusing optic and an integrated circuit that provides illumination light and includes an imaging array. The focusing optic includes meta-atoms formed on a substrate. The systems may have no moving parts and achieve imaging or image-projection fields-of-view approaching or exceeding 180 degrees. Because of their low part count, the systems can be robust and have a very small form factor. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556884 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/14 (20130101) Original (OR) Class A61B 3/113 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) G02B 27/0093 (20130101) G02B 27/0172 (20130101) G02B 2027/0147 (20130101) Electric Digital Data Processing G06F 3/013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110775 | Piercy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ROAM ROBOTICS INC. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brenton Piercy (San Francisco, California); Tim Swift (Albany, California); Giancarlo Nucci (San Francisco, California); Callum Lamb (San Bruno, California); Pete Lynn (Oakland, California); Saul Griffith (San Francisco, California); Leanne Luce (San Francisco, California) |
| ABSTRACT | A lower-leg exoskeleton that includes an actuator configured to be worn about a portion a leg of a user that is below the knee of the user; and a foot structure coupled to a first actuator end of the actuator, the foot structure configured to surround a portion of the foot of the user. The foot structure includes one or more sidewalls configured to extend around the foot of the user and including one or more sidewall attachment points for connecting to a base portion, and a base portion configured to reside at a base of the foot of the user and including one or more base attachment points coupling with the one or more sidewall attachment points. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558481 |
| CURRENT CPC | Characteristic Features of Footwear; Parts of Footwear A43B 13/20 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/60 (20130101) A61F 2/70 (20130101) A61F 2/74 (20210801) A61F 5/0127 (20130101) Original (OR) Class A61F 2002/501 (20130101) A61F 2005/0155 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0266 (20130101) A61H 3/00 (20130101) A61H 2003/007 (20130101) A61H 2201/0103 (20130101) A61H 2201/165 (20130101) A61H 2201/1238 (20130101) A61H 2201/1409 (20130101) A61H 2201/5007 (20130101) A61H 2201/5061 (20130101) A61H 2201/5069 (20130101) A61H 2205/12 (20130101) A61H 2205/106 (20130101) A61H 2230/30 (20130101) A61H 2230/50 (20130101) A61H 2230/60 (20130101) A61H 2230/207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110931 | Reddy |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | P. Hemachandra Reddy (Lubbock, Texas) |
| ABSTRACT | The present invention includes a method of inhibiting an activity of a BACE1 protein comprising contacting the BACE1 protein with a ligand that specifically inhibits residue Asp 32 of the human BACE1 protein. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/496921 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/222 (20130101) A61K 31/395 (20130101) A61K 31/473 (20130101) Original (OR) Class A61K 31/4015 (20130101) A61K 31/4196 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220110963 | Ting et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David T. Ting (Dover, Massachusetts); Mihir S. Rajurkar (Medford, Massachusetts) |
| ABSTRACT | Provided herein are reverse transcriptase (RT) blocking agents and methods of using the same for the treatment of cancer (e.g., an epithelial cancer) in a subject in need thereof. |
| FILED | Thursday, January 02, 2020 |
| APPL NO | 17/420550 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/505 (20130101) A61K 31/506 (20130101) A61K 31/522 (20130101) A61K 31/536 (20130101) A61K 31/675 (20130101) A61K 31/706 (20130101) A61K 31/4162 (20130101) A61K 31/4439 (20130101) A61K 31/7072 (20130101) Original (OR) Class A61K 31/7105 (20130101) A61K 38/465 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111443 | Hoy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | 3D Systems, Inc. (Rock Hill, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ahren Michael Hoy (Charlotte, North Carolina); Turner Ashby Cathey (Rock Hill, South Carolina); Alexander J. Geyling (Fort Mill, South Carolina) |
| ABSTRACT | An additive manufacturing system for producing a three-dimensional article includes a print engine, a post-fabrication powder removal apparatus, a transport mechanism, and a controller. The post fabrication removal apparatus includes a rotary frame defining an internal receptacle cavity, a plurality of clamps coupled to a corresponding plurality of actuators, a clamping plate coupled to a lift apparatus, and an agitation device mounted to the clamping plate. The controller is configured to perform the following steps: (1) Operate the transport mechanism to transport the build box to the internal receptacle cavity. (2) Operate the plurality of actuators to engage the build box with the plurality of clamps to secure the build box to the rotary frame. (3) Operate the rotary frame to rotate the build box until unfused powder begins to exit the build box. (4) Operate the agitation device to facilitate pouring of the unfused powder from the build box. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/402811 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/68 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112207 | FANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Eisai R and D Management Co., Ltd. (Bunkyo-ku, Tokyo, Japan) |
| ASSIGNEE(S) | Eisai R and D Management Co., Ltd. (Bunkyo-ku, Tokyo, Japan) |
| INVENTOR(S) | Francis G. FANG (Andover, Massachusetts); Branko MITASEV (North Reading, Massachusetts); Jiong YANG (Andover, Massachusetts) |
| ABSTRACT | A method for the synthesis of diazabicyclo[6.2.0]decane compounds is provided. The synthesis proceeds by stereoselective synthesis of a chiral lactone followed by azetidine formation via a series of chemoselective reactions. Bicyclization results with the formation of diazobicyclo[6.2.0]decane related compounds. |
| FILED | Thursday, January 09, 2020 |
| APPL NO | 17/421922 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 311/18 (20130101) Heterocyclic Compounds C07D 307/33 (20130101) C07D 403/06 (20130101) C07D 405/14 (20130101) C07D 487/04 (20130101) C07D 491/147 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112263 | Adusumilli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| INVENTOR(S) | Prasad S. Adusumilli (New York, New York); Michel Sadelain (New York, New York) |
| ABSTRACT | Disclosed herein are cells that are immune cells or precursor cells thereof, which cells recombinantly express a chimeric antigen receptor (CAR), and a dominant negative form of an inhibitor of a cell-mediated immune response of the immune cell, wherein the CAR binds to a cancer antigen. Also disclosed herein are T cells that recognize and are sensitized to a cancer antigen, which T cells recombinantly express a dominant negative form of an inhibitor of a T cell-mediated immune response. Additionally provided are methods of using such cells to treat cancer in a subject in need thereof. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557607 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/28 (20130101) A61K 38/00 (20130101) A61K 38/177 (20130101) A61K 38/193 (20130101) A61K 38/1774 (20130101) A61K 38/2013 (20130101) A61K 38/4873 (20130101) A61K 39/0011 (20130101) A61K 39/00117 (20180801) A61K 39/00118 (20180801) A61K 39/001104 (20180801) A61K 39/001106 (20180801) A61K 39/001109 (20180801) A61K 39/001112 (20180801) A61K 39/001113 (20180801) A61K 39/001114 (20180801) A61K 39/001119 (20180801) A61K 39/001122 (20180801) A61K 39/001124 (20180801) A61K 39/001126 (20180801) A61K 39/001128 (20180801) A61K 39/001129 (20180801) A61K 39/001153 (20180801) A61K 39/001157 (20180801) A61K 39/001166 (20180801) A61K 39/001168 (20180801) A61K 39/001171 (20180801) A61K 39/001174 (20180801) A61K 39/001182 (20180801) A61K 39/001186 (20180801) A61K 39/001188 (20180801) A61K 39/001192 (20180801) A61K 39/001193 (20180801) A61K 39/001195 (20180801) A61K 39/39558 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) Original (OR) Class C07K 14/70503 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70578 (20130101) C07K 16/30 (20130101) C07K 16/3069 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) C12N 9/6472 (20130101) C12N 2510/00 (20130101) Enzymes C12Y 304/22062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112332 | Moore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey S. Moore (Savoy, Illinois); Nancy R. Sottos (Champaign, Illinois); Kevin J. Schwarz (St. Paul, Minnesota); Katherine J. Stawiasz (Urbana, Illinois); Justine E. Paul (Savoy, Illinois) |
| ABSTRACT | A method of light-promoted frontal ring-opening metathesis polymerization includes providing a monomer solution including dicyclopentadiene, a ruthenium-based catalyst and a phosphite inhibitor, and exposing the monomer solution to ultraviolet light having a wavelength in a range from 315 nm to 400 nm, thereby initiating an exothermic polymerization reaction and generating a self-propagating polymerization front. The polymerization front moves through the monomer solution and polymerizes the dicyclopentadiene. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500436 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 2/50 (20130101) C08F 4/80 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112469 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Boris PETERLIN (San Francisco, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Irene Chen (Los Angeles, California); Huan Peng (Los Angeles, California); Samuel Verbanic (Los Angeles, California) |
| ABSTRACT | Novel chimeric proteins may be used to inhibit transcriptional A activities that are mediated by transcription factor interactions with P-TEFb. The chimeras contain elements that recruit the target transcription factor, maintain CDK9 in an inactive state, and competitively inhibit P-TEFb binding to the transcription factor. The chimeras may be configured for inhibition of HIV Tat mediated transcription and thus provide a novel means of preventing reactivation of integrated HIV, providing a new tool for emerging “block and lock” HIV cure strategies. |
| FILED | Wednesday, October 02, 2019 |
| APPL NO | 17/280506 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) A61K 45/06 (20130101) A61K 47/6929 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/553 (20130101) G01N 33/54346 (20130101) G01N 33/56911 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112524 | Arnold et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frances Arnold (Pasadena, California); Peter Meinhold (Pasadena, California); Matthew W. Peters (Pasadena, California); Rudi Fasan (Brea, California); Mike M.Y. Chen (Pasadena, California) |
| ABSTRACT | This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560753 |
| CURRENT CPC | Peptides C07K 14/32 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0042 (20130101) C12N 9/0071 (20130101) C12N 9/0077 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/04 (20130101) Original (OR) Class C12P 7/06 (20130101) Enzymes C12Y 106/02004 (20130101) C12Y 114/15 (20130101) C12Y 114/14001 (20130101) C12Y 114/15003 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 50/10 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/52 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112597 | Parker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Army DEVCOM Army Research Laboratory (Adelphi, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas C. Parker (Bel Air, Maryland); Richard T. Welker (Erding, Germany) |
| ABSTRACT | We present a novel technology to prevent water absorption into substrates and to prevent the hydrolysis process thereof. To these ends, we disclose very thin-film water-vapor barrier for applications to substrate surfaces and methods for manufacturing the same. A polymeric compound film and silica-like compound film form a bilayer and one or more bilayers form the barrier on the substrate. The thickness of the film layers is kept below the thin film interference thickness to ensure that the one or more transparent bilayers are substantially transparent to the light. The thin film interference thickness may be characterized as the wavelength of light (λ) divided by four (4) times the index of refraction (n) of the film materials. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/491530 |
| CURRENT CPC | Processes for Applying Fluent Materials to Surfaces, in General B05D 1/60 (20130101) B05D 1/62 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/50 (20130101) C23C 16/401 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113304 | Biris et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandru S. Biris (Little Rock, Arkansas); Andrew G. Kumpuris (Little Rock, Arkansas); Zeid Nima (Little Rock, Arkansas) |
| ABSTRACT | A method of making a nanocomposite includes forming at least one gold nanorod; coating a silver layer on an outer surface of the gold nanorod; assembling a Raman reporter molecule layer on the coated silver layer; coating a pegylated layer on the assembled Raman reporter molecule layer; and conjugating the coated pegylated layer with an active layer, the active layer comprising at least one of a targeting molecule configured to bind to the target of interest and a functional molecule configured to interact with the target of interest. |
| FILED | Thursday, August 12, 2021 |
| APPL NO | 17/400365 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) G01N 33/54346 (20130101) Original (OR) Class G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113308 | Kidwell |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Kidwell (Alexandria, Virginia) |
| ABSTRACT | The present invention provides a method for increasing the sensitivity of LFIAs by using palladium nanoparticles, selecting appropriate dye chemistries, and improving the timing of the development chemistry. In the presence of a palladium nanoparticle, three reagents interact with a catalytic label to form a colored dye. The three reagents include a hydrogen peroxide source, a color developer (a substituted para-phenylenediamine), and a color coupler (e.g. a napthol or a phenol). The timing of the development chemistry is improved by any combination of using a reducing agent, delaying hydrogen peroxide application by diffusion, using dissolving materials as a time delay, using serpentine flow, and separating the color coupler and the color developer on the strip. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560430 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/78 (20130101) G01N 33/531 (20130101) G01N 33/533 (20130101) G01N 33/558 (20130101) G01N 33/583 (20130101) G01N 33/587 (20130101) G01N 33/5306 (20130101) G01N 33/54346 (20130101) G01N 33/54393 (20130101) Original (OR) Class G01N 2021/7756 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113311 | Altieri, I |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | The Wistar Institute of Anatomy and Biology (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Dario C. Altieri, I (Philadelphia, Pennsylvania) |
| ABSTRACT | Therapeutic treatments of a tumor expressing pT346 PDK1, including glioma expressing pT346 PDK1, are disclosed. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561042 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2320/31 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57407 (20130101) Original (OR) Class G01N 2333/91215 (20130101) G01N 2440/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113321 | WANG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainsville, Florida); Banyan Biomarkers, Inc. (San Diego, California) |
| ASSIGNEE(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida); Banyan Biomarkers, Inc. (San Diego, California) |
| INVENTOR(S) | Kevin Ka-Wang WANG (Gainesville, Florida); Monika OLI (Gainesville, Florida); Ming-Cheng LIU (Gainesville, Florida) |
| ABSTRACT | The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/560144 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4064 (20130101) Peptides C07K 16/18 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6896 (20130101) Original (OR) Class G01N 2800/28 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113377 | Jolly et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | James R. Jolly (Merrimack, New Hampshire); Lynn M. Shepard (Litchfield, New Hampshire); Richard B. Elder, JR. (Bedford, New Hampshire); Richard A. Faust, III (Salem, New Hampshire); Susan F. Lindemann (Derry, New Hampshire) |
| ABSTRACT | An emitter ID ambiguity reduction system includes a Mission Data File Ambiguity Resolution matrix that contains both a) the INTEL-based emitter parameters data necessary to break emitter-by-emitter ambiguities, and b) the action(s) the Electronic Warfare (EW) system is to take to collect that data. Control software is triggered via either external command or per Mission Data File information (such as that contained in the Ambiguity Resolution Matrix). The emitter ID ambiguity reduction system includes Data collection hardware and firmware and Data Analysis OFP software algorithm(s). |
| FILED | Monday, April 20, 2020 |
| APPL NO | 16/764241 |
| CURRENT CPC | Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 45/0015 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/41 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113689 | Behandish et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Morad Behandish (Mountain View, California); Saigopal Nelaturi (Mountain View, California); Johan de Kleer (Los Altos, California) |
| ABSTRACT | A computer is provided with a geometric representation of an as-designed part and a set of hybrid manufacturing capabilities. The computer computes a set of additive and subtractive manufacturing primitives from the provided set of hybrid manufacturing capabilities, and intersects the primitives to generate an atomic decomposition of space. The computer uses the atomic decomposition to generate a non-geometric representation of a space of manufacturable parts with hybrid manufacturing capabilities in at least one of symbolic, logical, and combinatorial forms. At least one of a necessary, sufficient, or necessary-and-sufficient condition for manufacturability is tested via examining the non-geometric representation for the existence of at least one feasible process plan whose outcome is an as-manufactured part that is interchangeable with the as-designed part. |
| FILED | Tuesday, October 13, 2020 |
| APPL NO | 17/069087 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/041 (20130101) Original (OR) Class G05B 2219/13167 (20130101) Electric Digital Data Processing G06F 30/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220114473 | Awasthy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | International Business Machines Corporation (Armonk, New York) |
| INVENTOR(S) | Parul Awasthy (Ossining, New York); Bishwaranjan Bhattacharjee (Yorktown Heights, New York); John Ronald Kender (Leonia, New York); Radu Florian (Danbury, Connecticut); Hui Wan (White Plains, New York) |
| ABSTRACT | A computer system, product, and method are provided. The computer system includes an artificial intelligence (AI) platform operatively coupled to a processor. The AI platform includes tools in the form of a machine learning model (MLM) manager, a metric manager, and a training manager. The MLM manager accesses a plurality of pre-trained source MLMs, and inputs a plurality of data objects of a test dataset into each of the source MLMs. The test dataset includes the plurality of data objects associated with respective labels. For each source MLM, associated labels are generated from the inputted data objects and a similarity metric is calculated. The MLM manager selects a base MLM to be used for transfer learning from the plurality of source MLMs based upon the calculated similarity metric. The training manager trains the selected base MLM with a target dataset for the target domain. |
| FILED | Friday, October 09, 2020 |
| APPL NO | 17/066685 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/285 (20190101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220114809 — Stereoscopic Camera System for Geo-registration of 3D Reconstructed Points and Vectors
| US 20220114809 | Zuniga Zamalloa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Carlo C. Zuniga Zamalloa (Slidell, Louisiana); Blake J. Landry (Saint Martinville, Louisiana); Edward F. Braithwaite, III (Covington, Louisiana) |
| ABSTRACT | Systems and methods may include tracking one or a plurality features across a decreasing scale of tiled sets of one or more images. Aspects may include generating point data for each of the tracked features based on a coordinate system relative to the first camera or the second camera, and transforming the point data to a Global Positioning System/Inertial Navigation System (GPS/INS) coordinate system based on (1) an origin of a first GPS device coupled to the first camera and (2) a rotation of the first camera relative to an INS device coupled to the first camera. Aspects may include generating, based on the transformed point data, a geodetic mapping function, determining, based on the geodetic mapping function, georegistered coordinates of the tracked features, using the georegistered coordinates of the tracked features to characterize the water flow. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497791 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/70 (20170101) G06T 7/97 (20170101) G06T 2207/10028 (20130101) G06T 2207/30181 (20130101) Image or Video Recognition or Understanding G06V 20/10 (20220101) Original (OR) Class Wireless Communication Networks H04W 4/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115159 | Houten et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Spark Thermionics, Inc. (Emeryville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyana Van Houten (Berkeley, California); Lucas Heinrich Hess (Berkeley, California); Jared William Schwede (Berkeley, California); Felix Schmitt (Berkeley, California) |
| ABSTRACT | A thermionic energy conversion system, preferably including one or more electron collectors, interfacial layers, encapsulation, and/or electron emitters. A method for manufacturing the thermionic energy conversion system. A method of operation for a thermionic energy conversion system, preferably including receiving power, emitting electrons, and receiving the emitted electrons, and optionally including convectively transferring heat. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/555907 |
| CURRENT CPC | Obtaining Energy From Radioactive Sources; Applications of Radiation From Radioactive Sources, Not Otherwise Provided For; Utilising Cosmic Radiation G21H 1/106 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115503 | Cho et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Cornell University (Ithaca, New York); University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kyeongjae Cho (Frisco, Texas); Yaoqiao Hu (Richardson, Texas); Darrell Galen Schlom (Ithaca, New York); Suman Datta (South Bend, Indiana) |
| ABSTRACT | Provided by the inventive concept are electronic devices, such as semiconductor devices, including p-type oxide materials having and selected for having improved hole mobilities, band gaps, and phase stability, and methods for fabricating electronic devices having such p-type oxide materials. |
| FILED | Monday, October 12, 2020 |
| APPL NO | 17/068337 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/24 (20130101) Original (OR) Class H01L 29/7869 (20130101) H01L 29/66969 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115593 | Singh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Akash Singh (Durham, North Carolina); Manoj Jana (Durham, North Carolina); David B. Mitzi (Durham, North Carolina) |
| ABSTRACT | The present disclosure describes an organic-inorganic metal-halide-based semiconducting material that melts at lower temperatures compared to conventional inorganic semiconductors. The hybrid material is structurally engineered to easily access both crystalline and amorphous glassy states, with each state offering distinct physical properties. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333862 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0005 (20130101) Original (OR) Class H01L 51/0007 (20130101) H01L 51/0026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115829 | Bukowski |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leva E. Bukowski (Plano, Texas) |
| ABSTRACT | An apparatus includes a diffractive grating configured to receive multiple output beams from an array of laser sources. The apparatus also includes one or more optical elements configured to receive, direct, and focus multiple zeroth-order light beams, where the zeroth-order light beams include portions of the output beams reflected off the diffractive grating. The apparatus further includes a detector configured to receive the zeroth-order light beams from at least one of the one or more optical elements and process the zeroth-order light beams to generate diagnostic information. |
| FILED | Thursday, October 08, 2020 |
| APPL NO | 17/066320 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/4257 (20130101) Optical Elements, Systems, or Apparatus G02B 17/023 (20130101) G02B 27/30 (20130101) G02B 27/4233 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0014 (20130101) Original (OR) Class H01S 3/067 (20130101) H01S 3/2383 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220115957 — High-bandwidth analog-controlled DC breaker on DC/DC converter with galvanic isolation
| US 20220115957 | Smith |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | US Gov't as represented by Secretary of Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathaniel Smith (Lebanon, Ohio) |
| ABSTRACT | A galvanic isolator circuit and method provide for galvanically isolating and current limiting a power source from a load. A direct current (DC) input voltage (“vin”) and an input current (“iin”) are received. A full- or half-bridge rectifier is switched to synthesize a first alternating voltage waveform that magnetically couples through a transformer to induce a second alternating voltage waveform with galvanic isolation from the first alternating voltage waveform, preventing potentially-faulted load from a source. The second alternating voltage waveform is rectified to produce a direct current (DC) output voltage (“vo”) having output current (“io”) through more than one drive transistor or diode. The more than one primary-side drive transistor is current limited to reduce or prevent brown-out, black-out, or protective race conditions in the non-faulted portions of DC power generation systems and DC distribution electrical power systems. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/558922 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/325 (20210501) H02M 3/33571 (20210501) H02M 3/33573 (20210501) Original (OR) Class H02M 3/33592 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220116197 | Adams et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Norman H. Adams (Fulton, Maryland); Jeffrey A. Boye (Silver Spring, Maryland); Adam V. Crifasi (Wheaton, Maryland); Blair C. Fonville (Woodstock, Maryland); Ian M. Hughes (Jessup, Maryland); Amit Shah (Columbia, Maryland); Gregory L. Weaver (Carlisle, Pennsylvania); John F. Youssef (Frederick, Maryland); Darrell A. Zinn (Clarksville, Maryland) |
| ABSTRACT | A time transfer modem includes a radio frequency integrated circuit (RFIC), a radio frequency (RF) front end, and processing circuitry. The RF front end is configured to receive and up-convert an input for time transfer with a remote station to generate an up-converted timing signal centered at a select frequency that is outside of a frequency range of interest but within an operational frequency range of the RFIC. The RF front end may also be configured to attenuate, via a pre-selection filter, up-converted adjacent signals to generate a filtered timing signal at the select frequency. The RFIC may be configured to down-convert and digitize the filtered timing signal to generate a digitized timing signal for signal processing by the processing circuitry to determine a clock difference between a local clock signal and the digitized timing signal that originated from the remote station. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313308 |
| CURRENT CPC | Transmission H04B 1/40 (20130101) H04B 1/69 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0012 (20130101) H04L 7/0087 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220116206 | KEHLET et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Intel Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David KEHLET (Los Altos Hills, California); Shuanghong SUN (Sunnyvale, California); Saikumar JAYARAMAN (Chandler, Arizona); Fariaz KARIM (Gilbert, Arizona) |
| ABSTRACT | A first semiconductor device includes a processor configured to generate a random number at initial test of a second semiconductor device after fabrication of the second semiconductor device in a supply chain related to the second semiconductor device, and send the generated random number to the second semiconductor device. The processor is further configured to receive a first signature that is signed over the sent random number by the second semiconductor device using a first private key that is stored in the second semiconductor device, among a first private and public key pair, and test the received first signature, using a first public key that is stored in the first semiconductor device, among the first private and public key pair, to determine whether the second semiconductor device is authenticated. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/558627 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/586 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0825 (20130101) Original (OR) Class H04L 9/0866 (20130101) H04L 9/3247 (20130101) H04L 9/3263 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220116556 | GENOV et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (Toronto, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roman GENOV (Toronto, Canada); Kiriakos Neoklis KUTULAKOS (Toronto, Canada); Navid SARHANGNEJAD (Toronto, Canada); Nikola KATIC (Toronto, Canada); Mian WEI (Mississauga, Canada) |
| ABSTRACT | There is provided a method and system for pixel-wise imaging of a scene. The method including: receiving a pixel-wise pattern, the pixel-wise pattern including a masking value for each pixel in an array of pixels of an image sensor; producing an electronic signal at each pixel when such pixel is exposed to light received from the scene; and directing the electronic signal at each pixel to one or more collection nodes associated with such pixel based on the respective masking value, the one or more collection nodes each capable of integrating the received electronic signal. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500407 |
| CURRENT CPC | Pictorial Communication, e.g Television H04N 5/3535 (20130101) Original (OR) Class H04N 13/254 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220111356 | SADOW et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (Ames, Iowa); CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron D. SADOW (Ames, Iowa); Wenyu HUANG (Ames, Iowa); Frédéric A. PERRAS (Ames, Iowa); Marek PRUSKI (Ames, Iowa); Akalanka TENNAKOON (Ames, Iowa); Xun WU (Ames, Iowa); Anne M. LAPOINTE (Ithaca, New York) |
| ABSTRACT | Disclosed herein is a catalyst which comprises a silica core having an outer surface and a mesoporous silica shell having an outer surface and an inner surface with the inner surface being inside the outer surface of said mesoporous silica shell proximate to and surrounding the outer surface of said silica core. Wherein the outer surface of the mesoporous silica shell has openings leading to pores within the mesoporous silica shell which extend toward the outer surface of said silica core. The catalyst also includes catalytically active metal nanoparticles positioned within the pores proximate to said core, wherein the catalytic metal nanoparticles comprise about 0.0001 wt % to about 1.0 wt % of the catalyst. Also disclosed are methods of making the catalyst and using it to carry out a process for catalytically hydrogenolysizing a polyolefinic polymer. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497206 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/08 (20130101) B01J 23/42 (20130101) Original (OR) Class B01J 35/023 (20130101) B01J 35/026 (20130101) B01J 35/1061 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 11/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111361 | NATESAKHAWAT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania); NATIONAL ENERGY TECHNOLOGY LABORATORY (NETL) (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania); NATIONAL ENERGY TECHNOLOGY LABORATORY (NETL) (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Sittichai NATESAKHAWAT (Pittsburgh, Pennsylvania); Christopher MATRANGA (Pittsburgh, Pennsylvania); Douglas KAUFFMAN (Pittsburgh, Pennsylvania); Congjun WANG (Bethel Park, Pennsylvania); Yunyun ZHOU (South Park, Pennsylvania) |
| ABSTRACT | The invention relates to nanocatalysts composed of iron oxide nanoparticles supported on porous interconnected carbon nanosheets (CNS) fabricated from the carbonization of potassium citrate, that are remarkably active for CO2 hydrogenation and Fischer-Tropsch to Olefins (FTO) synthesis, as well as a method for directly converting CO2 and H2 to C2-C4 olefins and direct FTO synthesis. |
| FILED | Monday, January 13, 2020 |
| APPL NO | 17/420779 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/18 (20130101) B01J 23/745 (20130101) Original (OR) Class B01J 27/22 (20130101) B01J 37/18 (20130101) B01J 37/088 (20130101) B01J 37/0207 (20130101) B01J 37/0221 (20130101) Acyclic or Carbocyclic Compounds C07C 1/044 (20130101) C07C 2527/22 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111584 | Moran |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bryan D. Moran (Pleasanton, California) |
| ABSTRACT | A large area projection micro stereolithography (LAPuSL) system uses an addressable spatial light modulator (SLM) in coordination with an optical scanning system to make very large stereolithographically produced objects. The SLM is imaged onto a photosensitive material with an optical system that has the ability to scan the image over a large area and speedily manufacture large scale complex three dimensional components with micro scale features. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/456084 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/135 (20170801) Original (OR) Class Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2009/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 50/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112094 | Xiao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington); Albemarle Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Jie Xiao (Richland, Washington); Ran Yi (Richland, Washington); Yujing Bi (Richland, Washington); Job T. Rijssenbeek (Lake Wylie, South Carolina); Xiaoguang Hao (Fremont, California); Subramanian Venkatachalam (Charlotte, North Carolina); Liu Luo (Belmont, North Carolina) |
| ABSTRACT | Methods for synthesizing crystalline Ni-rich cathode materials are disclosed. The Ni-rich cathode material may have a formula LiNixMnyMzCo1−x−y−zO2, where M represents one or more dopant metals, x≥0.6, 0.01≤y<0.2, 0≤z≤0.05, and x+y+z≤1.0. The methods are cost-effective, and include methods for solid-state, molten-salt, and flash-sintering syntheses. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523734 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/50 (20130101) Original (OR) Class Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112124 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dominic F. Lee (Knoxville, Tennessee); Jaehyeung Park (Knoxville, Tennessee); Jaswinder Sharma (Oak Ridge, Tennessee); Georgios Polyzos (Knoxville, Tennessee) |
| ABSTRACT | A method for applying a coating to a surface includes the step of providing a reaction mixture comprising a silicon alkoxide and an alcohol. A reaction limiting amount of water is added. The silicon alkoxides and water are allowed to react to form silica precursor particles during an initial reaction period. A coating precursor composition is prepared by adding an acid soluble in the alcohol to the reaction mixture during a second reaction period after the initial reaction period. The precursor silica particles grow to form silica nanofeatures having a major dimension that is larger than a major dimension of the silica precursor particles. The coating precursor composition is applied to a surface, and the alcohol and water are allowed to evaporate and the silica nanofeatures to adhere to the surface and form a nanostructured layer on the surface. A coating precursor composition and a coated article are also disclosed. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556201 |
| CURRENT CPC | Chemical Composition of Glasses, Glazes or Vitreous Enamels; Surface Treatment of Glass; Surface Treatment of Fibres or Filaments Made From Glass, Minerals or Slags; Joining Glass to Glass or Other Materials C03C 17/25 (20130101) Original (OR) Class C03C 2217/73 (20130101) C03C 2217/77 (20130101) C03C 2217/90 (20130101) C03C 2217/213 (20130101) C03C 2218/32 (20130101) C03C 2218/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112146 | YU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Miao YU (Pittsford, New York); Huazheng LI (Troy, New York) |
| ABSTRACT | The dehydration membrane reactor for methanol production from CO2 hydrogenation includes one or more porous supports, a dehydration membrane on the one or more porous supports, and a catalyst layer on the dehydration membrane. The one or more porous supports include hollow ceramic fibers and the dehydration membrane includes NaA zeolite. The reactor is made by dip-coating the porous supports in a zeolite crystal seed solution and drying the coated porous support. The coated porous support is dried at about 80° C. and then heated to a temperature above about 200° C. The NaA zeolite membrane is then grown on the seeded support, and a catalyst layer is applied to the zeolite membrane. A feedstream including carbon dioxide and hydrogen is fed to the catalyst layer, where a product stream including methanol and water is evolved. The water is then removed from the product stream through the dehydration membrane to produce a high-purity methanol product. |
| FILED | Wednesday, January 22, 2020 |
| APPL NO | 17/424234 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/2475 (20130101) B01J 21/04 (20130101) B01J 23/72 (20130101) B01J 23/80 (20130101) B01J 29/7607 (20130101) B01J 37/0246 (20130101) B01J 2219/1943 (20130101) B01J 2229/64 (20130101) Acyclic or Carbocyclic Compounds C07C 29/60 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112166 | Jorgensen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William L. Jorgensen (Deep River, Connecticut); Joseph Schlessinger (Woodbridge, Connecticut) |
| ABSTRACT | The compounds of Formula I described herein regulate activity of JAK2 by specifically binding to the JAK2 pseudokinase domain, JH2, and are useful as therapeutic agents in the treatment or amelioration of myeloproliferative disorders. Also provided herein are methods of treating myeloproliferative disorders, and methods of making compounds of Formula I. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500622 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4196 (20130101) A61K 31/4245 (20130101) A61K 31/4439 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 249/14 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 405/12 (20130101) C07D 413/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112531 | Wehrs et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); NATIONAL TECHNOLOGY AND ENGINEERING SOLUTIONS OF SANDIA, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Maren Wehrs (Emeryville, California); John M. Gladden (Alameda, California); Aindrila Mukhopadhyay (Oakland, California) |
| ABSTRACT | The present invention provides for a genetically modified fungal host cell capable of producing indigoidine, wherein the host cell comprises a non-ribosomal peptide synthetase (NRPS) that converts glutamine to indigoidine. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405927 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/81 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/165 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/865 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112596 | Lu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yi-Hsien Lu (El Cerrito, California); Xiao Zhao (El Cerrito, California); Matthijs van Spronsen (Berkeley, California); Adam Schwartzberg (Richmond, California); Miquel Salmeron (Kensington, California); Carlos Morales Sanchez (Cottbus, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to thin free-standing oxide membranes. In one aspect, a method includes providing a substrate. The substrate defines a hole having a diameter of about 500 nanometers to 5000 nanometers. A layer of metal is deposited on the substrate. A supporting layer is deposited on the layer of metal. A first side of the supporting layer is the side that is disposed on the layer of metal. A metal oxide layer is deposited on the first side of the supporting layer and on the substrate. In some implementations, the method further includes removing the supporting layer. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/449900 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/40 (20130101) Original (OR) Class C23C 16/0281 (20130101) C23C 16/45536 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113034 | Moore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Broan-NuTone LLC (Hartford, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mike Moore (Hartford, Wisconsin); Richard R. Sinur (Hartford, Wisconsin); Jason Asmus (Hartford, Wisconsin); Seddik Rougab (Hartford, Wisconsin); Taylor Schroeder (Hartford, Wisconsin); Eric Theriault (Hartford, Wisconsin) |
| ABSTRACT | A venting system in accordance with the present disclosure includes a ventilation fan and one or more sensors coupled to the ventilation fan. The ventilation fan is positioned to vent air from an indoor environment. The sensors are positioned to monitor conditions in the indoor environment and selectively operate the ventilation fan to condition air in the indoor environment. |
| FILED | Wednesday, November 27, 2019 |
| APPL NO | 17/298362 |
| CURRENT CPC | Domestic Stoves or Ranges; Details of Domestic Stoves or Ranges, of General Application F24C 15/20 (20130101) F24C 15/2021 (20130101) Original (OR) Class Air-conditioning; Air-humidification; Ventilation; Use of Air Currents for Screening F24F 7/007 (20130101) F24F 11/0001 (20130101) F24F 2110/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113190 | Rimshaw et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam Rimshaw (Fairfield, Pennsylvania); Christopher Grieco (Yonkers, New York); Eric Kennehan (Berlin Center, Ohio); John B. Asbury (State College, Pennsylvania) |
| ABSTRACT | A high-sensitivity nanosecond to millisecond transient absorption spectrometer for measurements of miniscule signals under low excitation intensities includes an excitation source generating a >100 Hz, <5 ns pulsewidth excitation pulse for exciting a light absorbing sample, a probe light source for generating a high photon flux probe light beam producing an average irradiance greater than 1 μW m-2 nm-1 for measuring the transient absorption spectrum of the sample before and after excitation by the excitation source, a DC-coupled detector capable of measuring light for enabling synchronous measurement of both the transmission of the probe light beam and the change in transmission of the probe light beam between a signal with the excitation pulse present and a signal in the absence of the excitation pulse, and a digital oscilloscope with a trigger rearm time capable of collecting every trigger event at frequencies including 1 MHz, for enabling sequential noise subtraction protocols. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529869 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/18 (20130101) G01J 3/42 (20130101) Original (OR) Class G01J 3/0297 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/31 (20130101) G01N 2021/3125 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 13/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113273 | Agbo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Agbo (Oakland, California); David Larson (Helena, Montana) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to electrochemistry. In one aspect, an apparatus includes a light source and a potentiostat. The potentiostat is operable to be connected to an electrochemical cell. A counter electrode connection of the potentiostat is operable to be connected to a photoelectrode of the electrochemical cell. A working electrode connection of the potentiostat is operable to be connected to the working electrode of the electrochemical cell. The light source positioned to illuminate the photoelectrode when the light source is operating. When the apparatus is in operation, the potentiostat is used to bias the photoelectrode to allow for control of the voltage applied to the electrochemical cell, and an intensity of light incident upon the photoelectrode is varied to allow for control of the current applied to the electrochemical cell. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495631 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/305 (20130101) Original (OR) Class G01N 27/417 (20130101) G01N 27/3277 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113529 | Bond et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tiziana C. Bond (Livermore, California); Matthew A. Horsley (Danville, California); Shervin Kiannejad (Brentwood, California); Ted Laurence (Livermore, California); Ty Samo (Walnut Creek, California); Peter Weber (Berkeley, California); Xiyu Yi (Livermore, California) |
| ABSTRACT | Devices, systems and methods for widefield three-dimensional (3D) microscopy with a quantum entanglement light source are described. An example method includes generating a first set of photons and a second set of photons, wherein each of the photons in the first set is quantum entangled with a corresponding photon in the second set, directing the second set of photons toward a sample and simultaneously directing the first set of photons toward a first two-dimensional (2D) detector, detecting, from the sample, a plurality of photons at a second 2D detector, analyzing detections from the first and second 2D detectors to determine coincidence information, and determining one or more characteristics associated with at least a three-dimensional (3D) section of the sample based on collective detections at the first and the second 2D detectors. |
| FILED | Wednesday, October 14, 2020 |
| APPL NO | 17/070654 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/06 (20130101) G02B 21/361 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3501 (20130101) Pictorial Communication, e.g Television H04N 13/254 (20180501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113674 | RAVIZZA |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| INVENTOR(S) | Frank RAVIZZA (Brentwood, California) |
| ABSTRACT | Differential Holography technology measures the amplitude and/or phase of, e.g., an incident linearly polarized spatially coherent quasi-monochromatic optical field by optically computing the first derivative of the field and linearly mapping it to an irradiance signal detectable by an image sensor. This information recorded on the image sensor is then recovered by a simple algorithm. In some embodiments, an input field is split into two or more beams to independently compute the horizontal and vertical derivatives using amplitude gradient filters in orthogonal orientations) for detection on one image sensor in separate regions of interest (ROIs) or on multiple image sensors. A third unfiltered beam recorded in a third ROI directly measures amplitude variations in the input field to numerically remove its contribution as noise before recovering the original wavefront using a numerical in algorithm. When combined, the measured amplitude and phase constitute a holographic recording of the incident optical field. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/535277 |
| CURRENT CPC | Holographic Processes or Apparatus G03H 1/16 (20130101) Original (OR) Class G03H 1/0443 (20130101) G03H 1/0808 (20130101) G03H 2001/045 (20130101) G03H 2223/23 (20130101) G03H 2223/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113685 | CAVRARO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guido CAVRARO (Arvada, Colorado); Andrey BERNSTEIN (Golden, Colorado); Manish Kumar SINGH (Minneapolis, Minnesota) |
| ABSTRACT | Techniques for ripple-type control of networked physical systems such as power systems, water systems, and others are provided. As one example, a device includes at least one processor configured to determine, for a first controllable device in a system, based on a measurement of an output parameter and a minimum output parameter value, an output violation value for the first device. The processor is further configured to determine, based on a present input value for the first device, the output violation value, and an assistance requisition value corresponding to a second device, a target input value for the first device. The processor is further configured to cause the first controllable device to modify operation based on the target input value and a maximum input value for the first controllable device. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501743 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 9/02 (20130101) G05B 13/024 (20130101) Original (OR) Class Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220114075 | Bramley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NVIDIA Corporation (Santa Clara, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Gavin Bramley (Santa Clara, California); Philip Payman Shirvani (Santa Clara, California); Nirmal R. Saxena (Los Altos Hills, California) |
| ABSTRACT | Memory, used by a computer to store data, is generally prone to faults, including permanent faults (i.e. relating to a lifetime of the memory hardware), and also transient faults (i.e. relating to some external cause) which are otherwise known as soft errors. Since soft errors can change the state of the data in the memory and thus cause errors in applications reading and processing the data, there is a desire to characterize the degree of vulnerability of the memory to soft errors. In particular, once the vulnerability for a particular memory to soft errors has been characterized, cost/reliability trade-offs can be determined, or soft error detection mechanisms (e.g. parity) may be selectively employed for the memory. In some cases, memory faults can be diagnosed by redundant execution and a diagnostic coverage may be determined. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522417 |
| CURRENT CPC | Electric Digital Data Processing G06F 11/073 (20130101) G06F 11/0757 (20130101) G06F 11/1068 (20130101) G06F 11/3419 (20130101) G06F 11/3457 (20130101) G06F 11/3471 (20130101) Original (OR) Class G06F 11/3476 (20130101) G06F 2201/81 (20130101) G06F 2201/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115149 | BARRINGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT Advanced Technologies LLC (Lynchburg, Virginia); BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | BWXT Advanced Technologies LLC (Lynchburg, Virginia); BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Eric A. BARRINGER (Rustburg, Virginia); Russell R. JENSEN (Lynchburg, Virginia); Jeremy L. GUSTAFSON (Lynchburg, Virginia); Matt ALES (Puyallup, Washington); Joshua J. BERGMAN (Valensole, France); Ryan T. SWANSON (Lynchburg, Virginia); Jonathan K. WITTER (Forest, Virginia); Danny GALICKI (Knoxville, Tennessee); James B. INMAN (Forest, Virginia); Matt KRECICKI (Winter Park, Florida); Roger RIDGEWAY (Hurt, Virginia) |
| ABSTRACT | Carbide-based fuel assembly includes outer structural member of ceramic matrix composite material, the interior surface of which is lined in higher temperature regions with an insulation layer of porous refractory ceramic material. A continuous insulation layer extends the length of the fuel assembly or separate insulation layer sections have a thickness increasing step-wise along the length of the fuel assembly from upper (inlet) section towards bottom (outlet) section. A fuel element positioned inward of the insulation layer and between support meshes has a fuel composition including HALEU and has the form of a plurality of individual elongated fuel bodies or one or more fuel monolith bodies containing coolant flow channels. Fuel assemblies are distributively arranged in a moderator block, with upper end of the outer structural member attached to an inlet for propellant and lower end of the outer structural member operatively interfaced with a nozzle forming a NTP reactor. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399822 |
| CURRENT CPC | Jet-propulsion Plants F02K 9/425 (20130101) Nuclear Reactors G21C 3/07 (20130101) Original (OR) Class G21C 5/02 (20130101) G21C 5/126 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115152 | BARRINGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT Advanced Technologies LLC (Lynchburg, Virginia); BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | BWXT Advanced Technologies LLC (Lynchburg, Virginia); BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Eric A. BARRINGER (Rustburg, Virginia); Russell R. JENSEN (Lynchburg, Virginia); Jeremy L. GUSTAFSON (Lynchburg, Virginia); Matt ALES (Puyallup, Washington); Joshua J. BERGMAN (Valensole, France); Ryan T. SWANSON (Lynchburg, Virginia); Jonathan K. WITTER (Forest, Virginia); Danny GALICKI (Knoxville, Tennessee); James B. INMAN (Forest, Virginia); Matt KRECICKI (Winter Park, Florida); Roger RIDGEWAY (Hurt, Virginia) |
| ABSTRACT | Carbide-based fuel assembly includes outer structural member of ceramic matrix composite material (e.g., SiC—SiC composite), insulation layer of porous refractory ceramic material (e.g., zirconium carbide with open-cell foam structure or fibrous zirconium carbide), and interior structural member of refractory ceramic-graphite composite material (e.g., zirconium carbide-graphite or niobium carbide-graphite). Spacer structures between various layers provide a defined and controlled spacing relationship. A fuel element bundle positioned between support meshes includes a plurality of distributively arranged fuel elements or a solid, unitary fuel element with coolant channels, each having a fuel composition including high assay, low enriched uranium (HALEU). Fuel assemblies are distributively arranged in a moderator block and the upper end of the outer structural member is attached to a metallic inlet tube for hydrogen propellant and the lower end of the outer structural member is interfaced with a support plate, forming a NTP reactor. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399881 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/408 (20130101) Nuclear Reactors G21C 3/64 (20130101) Original (OR) Class G21C 3/322 (20130101) Nuclear Power Plant G21D 5/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115180 | Rastogi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DEERE and COMPANY (Moline, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sagar K. Rastogi (Raleigh, North Carolina); Brij N. Singh (West Fargo, North Dakota) |
| ABSTRACT | In accordance with one embodiment is a transformer with a core comprising a perimeter portion and central intervening portion. The central intervening portion is separated from the perimeter portion by air gaps, creating an opening on either side of the intervening portion. A primary winding and secondary winding are wound around the central intervening portion of the core. The primary winding is capable of electromagnetic interaction with the secondary winding. A pair of ferrite members arranged outward from a central axis of the central intervening portion of the core and increases a series inductance with the primary winding. In accordance with another aspect of the disclosure, each ferrite member may have an air gap associated with the core to facilitate heat dissipation from the transformer. |
| FILED | Sunday, August 08, 2021 |
| APPL NO | 17/396726 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 3/14 (20130101) H01F 27/38 (20130101) Original (OR) Class H01F 27/255 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/33584 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115547 | PRINCE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado); Colorado School of Mines (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Joseph PRINCE (Golden, Colorado); Colin Andrew WOLDEN (Denver, Colorado); Lance Michael WHEELER (Golden, Colorado) |
| ABSTRACT | The present disclosure relates to an all-back-contact photovoltaic device that includes, in order, a substrate, a first electrode having a first surface, an insulator, a second electrode having a second surface, and an active material, where the insulator and the second electrode form a cavity, the active material substantially fills the cavity and is in physical contact with the first surface and the second surface, the insulator includes a first layer and a second layer with the second layer positioned between the first layer and the second contact, and the first layer is constructed of a first material that is different than a second material used to construct the second layer. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498448 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/02167 (20130101) H01L 31/022441 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115650 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Amprius, Inc. (Fremont, California) |
| ASSIGNEE(S) | Amprius, Inc. (Fremont, California) |
| INVENTOR(S) | Weijie Wang (Sunnyvale, California); Zuqin Liu (Sunnyvale, California); Song Han (Foster City, California); Jonathan Bornstein (Cupertino, California); Constantin Ionel Stefan (San Jose, California) |
| ABSTRACT | Provided herein are nanostructures for lithium ion battery electrodes and methods of fabrication. In some embodiments, a nanostructure template coated with a silicon coating is provided. The silicon coating may include a non-conformal, more porous layer and a conformal, denser layer on the non-conformal, more porous layer. In some embodiments, two different deposition processes, e.g., a PECVD layer to deposit the non-conformal layer and a thermal CVD process to deposit the conformal layer, are used. Anodes including the nanostructures have longer cycle lifetimes than anodes made using either a PECVD or thermal CVD method alone. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/524206 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 4/366 (20130101) H01M 4/386 (20130101) Original (OR) Class H01M 4/0428 (20130101) H01M 4/1395 (20130101) H01M 10/052 (20130101) H01M 10/0525 (20130101) H01M 2004/027 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115680 | Holladay et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington); Emerald Energy NW, LLC (Bothell, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington); Emerald Energy NW, LLC (Bothell, Washington) |
| INVENTOR(S) | Jamie D. Holladay (Richland, Washington); John Barclay (Richland, Washington) |
| ABSTRACT | A process that includes pre-cooling a H2 gas feedstock with a compressed liquid natural gas via a heat exchanger, introducing the pre-cooled H2 gas feedstock into an active magnetic regenerative refrigerator H2 liquefier module, and delivering liquid H2 from the active magnetic regenerative refrigerator H2 liquefier module to a liquid H2 vehicle dispenser. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/543318 |
| CURRENT CPC | Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 21/00 (20130101) Liquefaction, Solidification or Separation of Gases or Gaseous Mixtures by Pressure and Cold Treatment F25J 1/001 (20130101) F25J 1/0022 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/04208 (20130101) Original (OR) Class H01M 2250/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115693 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xi Chen (Oak Ridge, Tennessee); Nancy J. Dudney (Oak Ridge, Tennessee); Sergiy Kalnaus (Oak Ridge, Tennessee); Max J. Palmer (Oak Ridge, Tennessee); Andrew S. Westover (Oak Ridge, Tennessee) |
| ABSTRACT | A method for manufacturing an improved thin film composite solid electrolyte is provided. The method includes spray coating an aqueous suspension of ceramic particles onto a substrate to form a ceramic thin film. The film is sintered to form a porous ceramic structure having an interconnected necked morphology that defines cavities. The cavities are backfilled with an polymer electrolyte, for example a crosslinkable poly(ethylene oxide) (PEO)-based polymer electrolyte. The resulting thin film composite solid electrolyte is highly ionically conductive and mechanically robust with good manufacturability, particularly suitable for, but not limited to lithium metal batteries. The present method represents a departure from conventional mixing-then-casting methods and instead includes the fabrication of a solid electrolyte having a high ceramic volume fraction, high ionic conductivity, low thickness, and good chemical stability with metallic lithium. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/497023 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 2300/0082 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115706 | Cao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Xia Cao (Richland, Washington); Ji-Guang Zhang (Richland, Washington); Wu Xu (Richland, Washington) |
| ABSTRACT | Electrolytes for lithium ion batteries with carbon-based, silicon-based, or carbon- and silicon-based anodes include a lithium salt; a nonaqueous solvent comprising at least one of the following components: (i) an ester, (ii) a sulfur-containing solvent, (iii) a phosphorus-containing solvent, (iv) an ether, (v) a nitrile, or any combination thereof, wherein the lithium salt is soluble in the solvent; a diluent comprising a fluoroalkyl ether, a fluorinated orthoformate, a fluorinated carbonate, a fluorinated borate, a fluorinated phosphate, a fluorinated phosphite, or any combination thereof, wherein the lithium salt has a solubility in the diluent at least 10 times less than a solubility of the lithium salt in the solvent; and an additive having a different composition than the lithium salt, a different composition than the solvent, and a different composition than the diluent. In some electrolytes, the nonaqueous solvent comprises an ester. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/537149 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/386 (20130101) H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/587 (20130101) H01M 10/0567 (20130101) H01M 10/0568 (20130101) H01M 10/0569 (20130101) Original (OR) Class H01M 2300/0042 (20130101) H01M 2300/0051 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115958 | Rastogi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DEERE and COMPANY (Moline, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sagar K. Rastogi (Raleigh, North Carolina); Brij N. Singh (West Fargo, North Dakota) |
| ABSTRACT | A system and method of fault detection based on a detailed waveform analysis is presented for transient and steady-state fault operation of 3-Φ DAB converter. Main symptoms of the converter during normal and fault conditions have been identified and a unique pattern in DC bias of phase currents under fault mode is noted. The logic-based fault diagnosis scheme is used to detect the fault and identify the faulty transistor. |
| FILED | Sunday, August 08, 2021 |
| APPL NO | 17/396739 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/325 (20210501) H02M 3/155 (20130101) H02M 3/33584 (20130101) Original (OR) Class H02M 7/49 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220116070 | Majid et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arslan J. Majid (Salt Lake City, Utah); Hussein Moradi (Idaho Falls, Idaho); Behrouz Farhang-Boroujeny (Salt Lake City, Utah) |
| ABSTRACT | Various embodiments relate to spread spectrum communication. A communication system may include a base station and a user equipment. The base station may be configured to: add a cyclic prefix (CP) to each block of a number of blocks of a first direct sequence spread spectrum (DSSS) signal to generate a first cyclic prefix-direct sequence spread spectrum (CP-DSSS) signal; add artificial noise to the first CP-DSSS signal; and transmit, via a channel, the first CP-DSSS signal. The user equipment configured to receive the first CP-DSSS signal. Associated methods and communications systems are also disclosed. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/645220 |
| CURRENT CPC | Transmission H04B 1/7097 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117072 | Shumlak et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington); LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uri Shumlak (Seattle, Washington); Harry S. McLean (Seattle, Washington); Brian A. Nelson (Seattle, Washington) |
| ABSTRACT | An example plasma confinement system includes an inner electrode having a rounded first end that is disposed on a longitudinal axis of the plasma confinement system and an outer electrode that at least partially surrounds the inner electrode. The outer electrode includes a solid conductive shell and an electrically conductive material disposed on the solid conductive shell and on the longitudinal axis of the plasma confinement system. The electrically conductive material has a melting point within a range of 170° C. to 800° C. at 1 atmosphere of pressure. Related plasma confinement systems and methods are also disclosed herein. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/536487 |
| CURRENT CPC | Fusion Reactors G21B 1/05 (20130101) G21B 1/11 (20130101) G21B 1/17 (20130101) G21B 1/21 (20130101) G21B 1/115 (20130101) Plasma Technique; Production of Accelerated Electrically-charged Particles or of Neutrons; Production or Acceleration of Neutral Molecular or Atomic Beams H05H 1/06 (20130101) Original (OR) Class H05H 1/16 (20130101) H05H 1/54 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 30/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117109 | Sahu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Dak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raj Sahu (Oak Ridge, Tennessee); Emre Gurpinar (Oak Ridge, Tennessee); Burak Ozpineci (Oak Ridge, Tennessee) |
| ABSTRACT | A system and method for generating a heat sink for circuitry, such as a power module, that facilitates removal of heat from the circuitry. To improve power density of power modules, not only electrical but also thermal optimization may be carried out as the two subsystems closely interact with each other. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495098 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/28 (20200101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/209 (20130101) Original (OR) Class H05K 7/20272 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220110775 | Piercy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ROAM ROBOTICS INC. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brenton Piercy (San Francisco, California); Tim Swift (Albany, California); Giancarlo Nucci (San Francisco, California); Callum Lamb (San Bruno, California); Pete Lynn (Oakland, California); Saul Griffith (San Francisco, California); Leanne Luce (San Francisco, California) |
| ABSTRACT | A lower-leg exoskeleton that includes an actuator configured to be worn about a portion a leg of a user that is below the knee of the user; and a foot structure coupled to a first actuator end of the actuator, the foot structure configured to surround a portion of the foot of the user. The foot structure includes one or more sidewalls configured to extend around the foot of the user and including one or more sidewall attachment points for connecting to a base portion, and a base portion configured to reside at a base of the foot of the user and including one or more base attachment points coupling with the one or more sidewall attachment points. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/558481 |
| CURRENT CPC | Characteristic Features of Footwear; Parts of Footwear A43B 13/20 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/60 (20130101) A61F 2/70 (20130101) A61F 2/74 (20210801) A61F 5/0127 (20130101) Original (OR) Class A61F 2002/501 (20130101) A61F 2005/0155 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 1/0266 (20130101) A61H 3/00 (20130101) A61H 2003/007 (20130101) A61H 2201/0103 (20130101) A61H 2201/165 (20130101) A61H 2201/1238 (20130101) A61H 2201/1409 (20130101) A61H 2201/5007 (20130101) A61H 2201/5061 (20130101) A61H 2201/5069 (20130101) A61H 2205/12 (20130101) A61H 2205/106 (20130101) A61H 2230/30 (20130101) A61H 2230/50 (20130101) A61H 2230/60 (20130101) A61H 2230/207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220113251 | Bathel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINSTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett F. Bathel (Yorktown, Virginia); Joshua M. Weisberger (Newport News, Virginia) |
| ABSTRACT | Light is projected through a grid (e.g., a Ronchi ruling) and onto a background, where it forms an image of the ruling. The light from this projected image is then reflected back onto the same grid, with a polarizing refractor (e.g., a Rochon polarizing prism) imparting a small offset between the projected and reflected light, and then on to an imaging camera. Thus, a separate source and cutoff grid is not needed, resulting in a focusing schlieren system that is compact and easy to construct and align. In some embodiments, translation of the polarizing refractor along the instrument axis provides a sensitivity adjustment of the resulting schlieren images. Manipulation of the polarization state of the light through the system allows the projected and reflected light to be coincident, maintaining a small footprint for the system, which can be mounted to the front of the imaging camera. |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/490521 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 11/2513 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/455 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 5/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115149 | BARRINGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT Advanced Technologies LLC (Lynchburg, Virginia); BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | BWXT Advanced Technologies LLC (Lynchburg, Virginia); BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Eric A. BARRINGER (Rustburg, Virginia); Russell R. JENSEN (Lynchburg, Virginia); Jeremy L. GUSTAFSON (Lynchburg, Virginia); Matt ALES (Puyallup, Washington); Joshua J. BERGMAN (Valensole, France); Ryan T. SWANSON (Lynchburg, Virginia); Jonathan K. WITTER (Forest, Virginia); Danny GALICKI (Knoxville, Tennessee); James B. INMAN (Forest, Virginia); Matt KRECICKI (Winter Park, Florida); Roger RIDGEWAY (Hurt, Virginia) |
| ABSTRACT | Carbide-based fuel assembly includes outer structural member of ceramic matrix composite material, the interior surface of which is lined in higher temperature regions with an insulation layer of porous refractory ceramic material. A continuous insulation layer extends the length of the fuel assembly or separate insulation layer sections have a thickness increasing step-wise along the length of the fuel assembly from upper (inlet) section towards bottom (outlet) section. A fuel element positioned inward of the insulation layer and between support meshes has a fuel composition including HALEU and has the form of a plurality of individual elongated fuel bodies or one or more fuel monolith bodies containing coolant flow channels. Fuel assemblies are distributively arranged in a moderator block, with upper end of the outer structural member attached to an inlet for propellant and lower end of the outer structural member operatively interfaced with a nozzle forming a NTP reactor. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399822 |
| CURRENT CPC | Jet-propulsion Plants F02K 9/425 (20130101) Nuclear Reactors G21C 3/07 (20130101) Original (OR) Class G21C 5/02 (20130101) G21C 5/126 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115151 | JOGERST et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT Advanced Technologies LLC (Lynchburg, Virginia); BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | BWXT Advanced Technologies LLC (Lynchburg, Virginia); BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | James D. JOGERST (Forest, Virginia); Eric A. BARRINGER (Rustburg, Virginia) |
| ABSTRACT | CERMET fuel element includes a fuel meat of consolidated ceramic fuel particles (preferably refractory-metal coated HALEU fuel kernels) and an array of axially-oriented coolant flow channels. Formation and lateral positions of coolant flow channels in the fuel meat are controlled during manufacturing by spacer structures that include ceramic fuel particles. In one embodiment, a coating on a sacrificial rod (the rod being subsequently removed) forms the coolant channel and the spacer structures are affixed to the coating; in a second embodiment, a metal tube forms the coolant channel and the spacer structures are affixed to the metal tube. The spacer structures laterally position the coolant channels in spaced-apart relation and are consolidated with the ceramic fuel particles to form CERMET fuel meat of a fuel element, which are subsequently incorporated into fuel assemblies that are distributively arranged in a moderator block within a nuclear fission reactor, in particular for propulsion. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399859 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/15 (20130101) Cosmonautics; Vehicles or Equipment Therefor B64G 1/408 (20130101) Alloys C22C 1/05 (20130101) Jet-propulsion Plants F02K 7/02 (20130101) Nuclear Reactors G21C 3/64 (20130101) Original (OR) Class G21C 5/02 (20130101) G21C 5/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220115152 | BARRINGER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BWXT Advanced Technologies LLC (Lynchburg, Virginia); BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | BWXT Advanced Technologies LLC (Lynchburg, Virginia); BWXT Nuclear Energy, Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Eric A. BARRINGER (Rustburg, Virginia); Russell R. JENSEN (Lynchburg, Virginia); Jeremy L. GUSTAFSON (Lynchburg, Virginia); Matt ALES (Puyallup, Washington); Joshua J. BERGMAN (Valensole, France); Ryan T. SWANSON (Lynchburg, Virginia); Jonathan K. WITTER (Forest, Virginia); Danny GALICKI (Knoxville, Tennessee); James B. INMAN (Forest, Virginia); Matt KRECICKI (Winter Park, Florida); Roger RIDGEWAY (Hurt, Virginia) |
| ABSTRACT | Carbide-based fuel assembly includes outer structural member of ceramic matrix composite material (e.g., SiC—SiC composite), insulation layer of porous refractory ceramic material (e.g., zirconium carbide with open-cell foam structure or fibrous zirconium carbide), and interior structural member of refractory ceramic-graphite composite material (e.g., zirconium carbide-graphite or niobium carbide-graphite). Spacer structures between various layers provide a defined and controlled spacing relationship. A fuel element bundle positioned between support meshes includes a plurality of distributively arranged fuel elements or a solid, unitary fuel element with coolant channels, each having a fuel composition including high assay, low enriched uranium (HALEU). Fuel assemblies are distributively arranged in a moderator block and the upper end of the outer structural member is attached to a metallic inlet tube for hydrogen propellant and the lower end of the outer structural member is interfaced with a support plate, forming a NTP reactor. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399881 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/408 (20130101) Nuclear Reactors G21C 3/64 (20130101) Original (OR) Class G21C 3/322 (20130101) Nuclear Power Plant G21D 5/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220110319 | France et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TDA Research, Inc (Wheat Ridge, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher Brian France (Arvada, Colorado); William Bell (Boulder, Colorado) |
| ABSTRACT | We describe methods and materials for inhibiting the growth of a microbial pathogen of a plant. The method comprises the steps of applying to the plant a combination of a dye-bearing compound which is a reactive oxygen species photosensitizer; and a copper compound, which increases the microbial lethality of the dye-bearing compound towards the microbial pathogen; and exposing the plant to light to activate the combination of the dye-bearing compound and the copper compound and inhibiting growth of a microbial pathogen of a plant. The combination of the dye-bearing compound and the copper compound may result in a synergistic ability to reduce the growth of a plant pathogen. |
| FILED | Tuesday, September 24, 2019 |
| APPL NO | 17/278657 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/00 (20130101) Original (OR) Class A01N 59/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220111353 | Petruska et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Melissa A. Petruska (Newtown, Connecticut); Jeffrey F. Roeder (Brookfield, Connecticut); Trevor E. James (Plantsville, Connecticut); Peter C. Van Burkirk (Newtown, Connecticut); Thomas S. Spoonmore (Norwalk, Connecticut); Robert T. Henderson, III (New Milford, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa A. Petruska (Newtown, Connecticut); Jeffrey F. Roeder (Brookfield, Connecticut); Trevor E. James (Plantsville, Connecticut); Peter C. Van Burkirk (Newtown, Connecticut); Thomas S. Spoonmore (Norwalk, Connecticut); Robert T. Henderson, III (New Milford, Connecticut) |
| ABSTRACT | Monolithic composite photocatalysts for fluid purification are disclosed. The monolithic composite photocatalysts comprise a photoactive nanocrystal component and a non-photoactive porous support. Photocatalytic fluid purification systems that contact an impurity-containing fluid with the subject monolithic composite photocatalysts are also disclosed. The monolithic composite photocatalysts may be affixed to or embedded in scaffold structures to promote fluid flow through a fluid purification system and contact with the monolithic composite photocatalysts. |
| FILED | Tuesday, September 21, 2021 |
| APPL NO | 17/481279 |
| CURRENT CPC | Separation B01D 53/865 (20130101) B01D 53/8687 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/063 (20130101) Original (OR) Class B01J 35/004 (20130101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/50 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112381 | HUNT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heather HUNT (Columbia, Missouri); Azlin MUSTAPHA (Columbia, Missouri); Eduardo Torres DOMINQUEZ (Columbia, Missouri) |
| ABSTRACT | The present application relates to an antimicrobial coated substrate with one or more surfaces and a TiO2 coating on at least one of the surfaces of the substrate, where the coating has a rhombohedral microstructure. Also disclosed is a process for preparing an antimicrobial coated substrate with one or more surfaces and methods of killing microbes. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/499374 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 59/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220110939 | Gavegnano et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christina Gavegnano (Decatur, Georgia); Raymond F Schinazi (Miami, Florida) |
| ABSTRACT | Compounds, compositions, and methods of treatment and prevention of Hepacivirus, Pestivirus, Flavivirus or Alphavirus infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations of these JAK inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, and the like, are also disclosed. In one embodiment, the combinations include a combination of adenine, cytosine, thymidine, and guanine nucleoside antiviral agents, optionally in further combination with at least one additional antiviral agent that works via a different mechanism than a nucleoside analog. This combination has the potential to eliminate the presence of Hepacivirus, Pestivirus, Flavivirus or Alphavirus in an infected patient. |
| FILED | Tuesday, June 29, 2021 |
| APPL NO | 17/362103 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/52 (20130101) A61K 31/66 (20130101) A61K 31/513 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/536 (20130101) A61K 31/4045 (20130101) A61K 31/7072 (20130101) A61K 45/06 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220112542 | KHATRI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Purvesh KHATRI (Menlo Park, California); Aditya Manohar RAO (Stanford, California); David A. RELMAN (Palo Alto, California); Stephen POPPER (Stanford, California); Timothy E. SWEENEY (Redwood City, California) |
| ABSTRACT | This disclosure provides a gene expression-based method for determining whether a subject has a viral infection or a bacterial infection. A kit for performing the method is also provided. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/441670 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/70 (20130101) C12Q 1/686 (20130101) C12Q 1/689 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220110728 | Weitekamp et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | POLYSPECTRA, INC. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Raymond A. Weitekamp (Berkeley, California); Aditya Balasubramanian (Berkeley, California) |
| ABSTRACT | Described herein are compositions and methods for generating dental products or orthodontic products. The compositions and methods comprise latent ruthenium complexes and photoacids and/or photoacid generators. |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399368 |
| CURRENT CPC | Dentistry; Apparatus or Methods for Oral or Dental Hygiene A61C 13/0019 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 6/62 (20200101) A61K 6/887 (20200101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/35 (20170801) B29C 64/124 (20170801) Indexing Scheme Associated With Subclass B29C, Relating to Particular Articles B29L 2031/753 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220110737 — SYSTEMS, DEVICES, AND METHODS FOR THE RETRIEVAL OF AN IMPLANT IN THE PROSTATIC URETHRA
| US 20220110737 | Mehta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ZENFLOW, INC. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shreya Mehta (San Francisco, California); Aaron M. Weiss (Oakland, California); Austin Michael Bly (San Clemente, California) |
| ABSTRACT | Systems, devices, and methods are provided for retrieval of an implant from the prostatic urethra. Embodiments of retrieval systems can include a device for insertion into the patient and a proximal control device for use in grasping a portion of the implant and withdrawing the implant into a lumen of the retrieval system. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/495996 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/00234 (20130101) A61B 2017/00274 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/04 (20130101) Original (OR) Class A61F 2002/047 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220112017 | Steed |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secrelary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Darren Jay Steed (Egg Harbor Township, New Jersey) |
| ABSTRACT | The present application is directed to a packaging for a powdered explosive-detection training aid which may include first and second opposing flexible sheets heat sealed together along less than a periphery thereof and defining a storage compartment therebetween, wherein an unsealed portion of the periphery defines an opening to the storage compartment, wherein at least a portion of the first opposing flexible sheet is a semipermeable material permeable to a vapor emitted from the powdered explosive-detection training aid, with the second opposing flexible sheet being impermeable to the powdered explosive-detection training aid vapor; and a sealing member, wherein the sealing member is secured to the first opposing flexible sheet and, in a closing position, covers the semipermeable portion of the first opposing flexible sheet. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560513 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 15/02 (20130101) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 33/01 (20130101) B65D 75/30 (20130101) Original (OR) Class B65D 85/70 (20130101) B65D 2565/388 (20130101) Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 11/132 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 8/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20220112110 | Scheckel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government, as represented by the Administrator of the U.S. EPA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kirk Gerald Scheckel (Cincinnati, Ohio); Ranju R. Karna (Vicksburg, Mississippi); Charles R. Partridge (Commerce City, Colorado); Karen D. Bradham (Apex, North Carolina); David James Thomas (Chapel Hill, North Carolina); Matthew R. Noerpel (Cincinnati, Ohio); Jennifer Lynn Goetz (Petersburg, Kentucky); Todd Peter Luxton (Cincinnati, Ohio) |
| ABSTRACT | Methods and systems are provided for treating a contaminated environmental medium. In one example, the treatment includes adding a salt to the contaminated environmental medium to form a slurry. The slurry is heated to irreversibly precipitate a jarosite-group mineral incorporating contaminant cations and contaminant anions into its structure. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/450445 |
| CURRENT CPC | Disposal of Solid Waste B09B 3/0083 (20130101) Reclamation of Contaminated Soil B09C 1/06 (20130101) B09C 1/08 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/5236 (20130101) C02F 9/00 (20130101) Original (OR) Class Protection Against X-radiation, Gamma Radiation, Corpuscular Radiation or Particle Bombardment; Treating Radioactively Contaminated Material; Decontamination Arrangements Therefor G21F 9/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Non-Profit Organization (NPO)
| US 20220111443 | Hoy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | 3D Systems, Inc. (Rock Hill, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ahren Michael Hoy (Charlotte, North Carolina); Turner Ashby Cathey (Rock Hill, South Carolina); Alexander J. Geyling (Fort Mill, South Carolina) |
| ABSTRACT | An additive manufacturing system for producing a three-dimensional article includes a print engine, a post-fabrication powder removal apparatus, a transport mechanism, and a controller. The post fabrication removal apparatus includes a rotary frame defining an internal receptacle cavity, a plurality of clamps coupled to a corresponding plurality of actuators, a clamping plate coupled to a lift apparatus, and an agitation device mounted to the clamping plate. The controller is configured to perform the following steps: (1) Operate the transport mechanism to transport the build box to the internal receptacle cavity. (2) Operate the plurality of actuators to engage the build box with the plurality of clamps to secure the build box to the rotary frame. (3) Operate the rotary frame to rotate the build box until unfused powder begins to exit the build box. (4) Operate the agitation device to facilitate pouring of the unfused powder from the build box. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/402811 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 10/68 (20210101) Original (OR) Class Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220113030 | Vallejo Ruiz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ernesto Andres Vallejo Ruiz (Cincinnati, Ohio); Aaron Michael Dziech (Crittenden, Kentucky); Jonathon Eli Farmer (Newport, Kentucky) |
| ABSTRACT | A combustor assembly for a gas turbine engine defining a radial direction and a circumferential direction includes a liner assembly at least partially defining a combustion chamber and including at least one liner extending between a downstream end and an upstream end, the downstream end of the at least one liner defining a radial opening and an interface surface extending along the circumferential direction and along the radial direction; and a seal member including a body, a flange, and a radial element, the body defining a body surface extending along the radial direction and positioned adjacent the interface surface of the at least one liner, the flange extending forward from the body, and the radial element coupled to the flange and extending into the radial opening defined by the at least one liner. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/559686 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/023 (20130101) Jet-propulsion Plants F02K 1/82 (20130101) Generating Combustion Products of High Pressure or High Velocity, e.g Gas-turbine Combustion Chambers F23R 3/007 (20130101) F23R 3/60 (20130101) Original (OR) Class F23R 2900/00012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220114080 | Jackson, II et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gary L. Jackson, II (Laurel, Maryland); Sterling E. Vinson, II (Columbia, Maryland) |
| ABSTRACT | A test environment apparatus having processing circuitry is provided for testing an embedded system-under-test. The processing circuitry may be configured to implement the system-under-test for interaction with external test participants via messaging and control operation of an inner agent and an outer agent. The inner agent may be implemented within a virtual machine that is also implementing the system-under-test and the outer agent may be implemented external to the virtual machine implementing the system-under-test. The inner agent and the outer agent may be controlled to operate collaboratively to trigger captures of snapshots that store current states of the system-under-test at respective times and trigger a rollback of the system-under-test based on a timestamp of a delayed message using a snapshot for a selected time that provides a state of the system-under-test prior to the timestamp to permit subsequent delivery of the delayed message with the system-under-test in a rollback state. |
| FILED | Friday, June 25, 2021 |
| APPL NO | 17/358134 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/45558 (20130101) G06F 11/1469 (20130101) G06F 11/3664 (20130101) Original (OR) Class G06F 2009/45591 (20130101) G06F 2201/84 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117108 | West et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | Raytheon Company (, None) |
| INVENTOR(S) | Don W. West (Coppell, Texas); Evan Haynes (McKinney, Texas) |
| ABSTRACT | An electronic component connector cooling device can include a base portion and a conduit portion extending from the base portion. The conduit portion can have a cooling channel. The electronic component connector cooling device can further include a housing coupling interface formed in the base portion and operable to facilitate coupling the electronic component connector cooling device to a housing that at least partially forms an enclosure about an electronic component. The electronic component connector cooling device can also include a connector coupling interface formed in the base portion and operable to facilitate coupling a connector to the electronic component connector cooling device. The connector can operably connect the electronic component to a component external to the enclosure. The electronic component connector cooling device can further include an inlet port formed in the conduit portion and in fluid communication with the cooling channel. The inlet port can be operable to couple to a cooling fluid source external to the enclosure and to receive a cooling fluid from the cooling fluid source. The electronic component connector cooling device can include one or more outlet ports formed in the base portion and in fluid communication with the cooling channel operable to direct the cooling fluid internal to the enclosure to cool the electronic component. |
| FILED | Tuesday, October 13, 2020 |
| APPL NO | 17/069762 |
| CURRENT CPC | Electrically-conductive Connections; Structural Associations of a Plurality of Mutually-insulated Electrical Connecting Elements; Coupling Devices; Current Collectors H01R 13/622 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20009 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, April 14, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/details-patents-20220414.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page