FedInvent™ Patent Applications
Application Details for Thursday, April 21, 2022
This page was updated on Friday, April 22, 2022 at 10:23 AM GMT
Department of Health and Human Services (HHS)
| US 20220117191 | Tindal et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert J. Tindal (Birmingham, Alabama); Erik Dohm (Trussville, Alabama); Sam Misko (Birmingham, Alabama); Samuel Cartner (Birmingham, Alabama); Jaret Langston (Hoover, Alabama); Pam Bounelis (Mountain Brook, Alabama); Rachana Kotapalli (Alpharetta, Georgia); Emma Latham Godwin (Quinton, Alabama) |
| ABSTRACT | Disclosed are various embodiments for sensing and integrating data of environmental conditions in animal research. A collection device having a bracket is removably mounted to a cage. The collection device includes a sensor array that captures audio content or environmental measurements. A micro-environment monitor of the collection device can process the audio content to determine that audible or ultrasonic vocalizations of an animal are present. The micro-environment monitor sends data based at least in part on the audio content or environmental measurements to a computing environment. |
| FILED | Friday, March 20, 2020 |
| APPL NO | 17/431960 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 1/031 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 67/12 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 1/406 (20130101) H04R 3/005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117206 | Pi et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liya Pi (Gainesville, Florida); Daohong Zhou (Waldo, Florida) |
| ABSTRACT | Described are alcohol-induced liver cancer model mice, methods of generating the alcohol-induced liver cancer model mice, and methods of using the alcohol-induced liver cancer model mice. Methods of treating alcoholic liver disease, including hepatocellular carcinoma, are also described. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/504752 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/027 (20130101) Original (OR) Class A01K 2207/20 (20130101) A01K 2207/25 (20130101) A01K 2227/105 (20130101) A01K 2267/0331 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117220 | BROCKBANK |
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| FUNDED BY |
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| APPLICANT(S) | TISSUE TESTING TECHNOLOGIES LLC (North Charleston, South Carolina) |
| ASSIGNEE(S) | TISSUE TESTING TECHNOLOGIES LLC (North Charleston, South Carolina) |
| INVENTOR(S) | Kelvin GM BROCKBANK (Charleston, South Carolina) |
| ABSTRACT | A method for preserving and reducing the immunogenicity of a tissue, the method including obtaining a first tissue, the first tissue being a wild type tissue or genetically modified tissue; forming a second tissue by immersing the first tissue in a first solution having a cryoprotectant concentration of at least about 75% by weight for at least one hour to kill and lyse the cells of the first tissue; forming a third tissue by removing residual cell materials of the second tissue, the residual cell materials of the second tissue being removed by subjecting the second tissue to decellularization in a bioreactor; and subjecting the third tissue to ice-free cryopreservation. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506140 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117266 | Maier et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert J. Maier (Athens, Georgia); Stéphane Benoit (Bishop, Georgia) |
| ABSTRACT | This disclosure describes compositions including dimethylglyoxime (DMG) and methods of using those compositions including, for example, to reduce the availability of nickel in the subject. In some aspects, the composition may be administered to a subject suffering from or susceptible to a bacterial infection and/or to a subject suffering from or susceptible to a amyloid-β peptide aggregation. In some aspects, this disclosure describes using DMG or a composition including DMG to disrupt a biofilm or reduce the likelihood of biofilm formation. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514133 |
| CURRENT CPC | Fodder A23K 20/20 (20160501) Original (OR) Class A23K 20/105 (20160501) A23K 50/75 (20160501) Preparations for Medical, Dental, or Toilet Purposes A61K 33/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117508 | DHARMAKUMAR et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| INVENTOR(S) | Rohan DHARMAKUMAR (Moorpark, California); Hsin-Jung YANG (West Hollywood, California) |
| ABSTRACT | Described herein are methods for cardiovascular imaging for diagnosing and/or detecting various cardiovascular diseases. Various embodiments of the invention provide using magnetic resonance imaging of the cardiovascular system of a subject at rest or a normocapnic condition, as well as at a stressed or hypercapnic condition, in a repeated manner enhancing the statistical power, such that fast, motion-corrected, free-breathing, whole-heart imaging of the cardiovascular system is utilized to identify impaired cardiovascular function in a manner with improved specificity and accuracy. |
| FILED | Friday, February 07, 2020 |
| APPL NO | 17/428011 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/055 (20130101) Original (OR) Class A61B 5/0263 (20130101) A61B 5/0295 (20130101) A61B 5/4884 (20130101) A61B 5/14542 (20130101) A61B 2576/00 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/561 (20130101) G01R 33/5608 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) G06T 7/0014 (20130101) G06T 2207/10088 (20130101) G06T 2207/30048 (20130101) G06T 2207/30104 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117542 | Pandolfino et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John E. Pandolfino (Wilmette, Illinois); Wenjun Kou (Rockford, Illinois); Neelesh A. Patankar (Buffalo Grove, Illinois); Dustin Carlson (Chicago, Illinois) |
| ABSTRACT | Described here are systems and methods for four-dimensional manometry, which can include generating and displaying rendering data that simultaneously depict spacetime variations in impedance, pressure, and esophageal luminal morphology. From these data, bolus tracking and esophageal opening and velocity data can be measured and visualized without the need for additional imaging, thereby reducing a subject's exposure to otherwise necessary ionizing radiation. |
| FILED | Monday, November 18, 2019 |
| APPL NO | 17/309262 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/037 (20130101) A61B 5/0538 (20130101) A61B 5/4233 (20130101) Original (OR) Class A61B 5/7425 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117583 | El Kaffas et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ahmed El Kaffas (San Jose, California); Dimitre H. Hristov (Stanford, California); Ashwin C. Reddy (Mineola, New York) |
| ABSTRACT | A method for characterizing tissue, contrast agent behavior or microbubble behavior in dynamic contrast enhanced (DCE) medical image time-series data is provided. Time-series sequence of contrast enhanced medical imaging data is acquired during a contrast wash-in or a wash-out. Regions or volumes of interest (ROI/VOI) are selected and from those second order statistics is extracted at each frame of the time-series data. Each extracted second order statistic is assembled over time into a time-statistics curve (TSC). The TSC is normalized to emphasize a shape of the contrast behavior through the ROI or VOI instead of an intensity of the contrast behavior. The tissue, the contrast agent behavior, or the microbubble behavior is then characterized from the time-statistics curve. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504350 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/469 (20130101) A61B 8/481 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117684 | IORDACHITA et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Iulian I. IORDACHITA (Lutherville, Maryland); Jin Seob KIM (Ellicott City, Maryland); David LEVI (Baltimore, Maryland); Kevin CLEARY (Potomac, Maryland); Reza MONFAREDI (Rockville, Maryland) |
| ABSTRACT | A body mountable robot may include a set of stages disposed in a parallel configuration. The body mountable robot may include a set of actuating joints, wherein an actuating joint, of the set of actuating joints, is configured to rotate with respect to a corresponding stage of the set of stages. The body mountable robot may include at least one actuator, wherein the at least one actuator is configured to actuate at least one actuating joint of the set of actuating joints. The body mountable robot may include a set of scissor mechanisms, wherein a scissor mechanism, of the set of scissor mechanisms, that is coupled to the actuating joint, is supported by the corresponding stage, and wherein the scissor mechanism is configured to translate with respect to the corresponding stage. |
| FILED | Monday, November 26, 2018 |
| APPL NO | 16/768508 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 34/32 (20160201) Original (OR) Class A61B 90/11 (20160201) A61B 2017/3409 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117895 | Yeo et al. |
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| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Yoon Yeo (West Lafayette, Indiana); Hassan Tamam (Sohag, Egypt) |
| ABSTRACT | The present invention generally relates to a method for preparing a drug-loaded liposome, in particular to a method for preparing a drug-loaded liposome manufactured using hypertonic loading or a combination of hypertonic loading and remote loading of one or more drugs. The invention described herein also pertains to pharmaceutical compositions and methods for treating cancers. Both the manufacturing processes and the pharmaceutical products are within the scope of this disclosure. |
| FILED | Thursday, January 16, 2020 |
| APPL NO | 17/423492 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1272 (20130101) A61K 9/1278 (20130101) Original (OR) Class A61K 31/282 (20130101) A61K 31/337 (20130101) A61K 31/475 (20130101) A61K 31/519 (20130101) A61K 31/704 (20130101) A61K 31/4745 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117917 | Lu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); University of Maryland (College Park, Maryland); Indiana University Research and Technology Corporation (Indianapolis, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiongbin Lu (Carmal, Indiana); Xiaoming He (Bethesda, Maryland); Jiangsheng Xu (Greenbelt, Maryland) |
| ABSTRACT | Disclosed herein is a pH activated nanoparticle that can be used to deliver labile therapeutic or diagnostic agents to the cytoplasm of cells. These nanoparticles allow the agents to escape the endosome by releasing a gas in an amount effective to disrupt the endosome and release the agents into the cytoplasm. The disclosed nanoparticles have a shell, such as a phospholipid bilayer shell, and a core containing a gas bound to a substrate by a pH sensitive interaction. Also disclosed herein is are methods for delivering a pH sensitive cargo to the cytoplasm of a cell, treating triple negative breast cancer (TNBC) in a subject, and treating HER2+ breast cancer in a subject. |
| FILED | Wednesday, October 30, 2019 |
| APPL NO | 17/289425 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 31/155 (20130101) Original (OR) Class A61K 31/337 (20130101) A61K 31/704 (20130101) A61K 31/4436 (20130101) A61K 31/4745 (20130101) A61K 31/7105 (20130101) A61K 47/02 (20130101) A61K 47/10 (20130101) A61K 47/24 (20130101) A61K 47/34 (20130101) A61K 47/36 (20130101) A61K 47/183 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117922 | Chandraratna et al. |
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| FUNDED BY |
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| APPLICANT(S) | Io Therapeutics, Inc. (Spring, Texas); Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roshantha A. Chandraratna (San Juan Capistrano, California); Ethan Dmitrovsky (Hanover, New Hampshire); Elizabeth Nowak (West Lebanon, New Hampshire); Randolph Noelle (Plainfield, New Hampshire) |
| ABSTRACT | The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/560035 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 31/47 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/201 (20130101) A61K 31/216 (20130101) A61K 31/343 (20130101) A61K 31/353 (20130101) A61K 31/4704 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117937 | Rivera et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana); University of Kansas (Lawrence, Kansas); Oklahoma State University (Stillwater, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana); University of Kansas (Lawrence, Kansas); Oklahoma State University (Stillwater, Louisiana) |
| INVENTOR(S) | Mario Rivera (Baton Rouge, Louisiana); Huili Yao (Baton Rouge, Louisiana); Richard A. Bunce (Stillwater, Oklahoma); Baskar Nammalwar (San Diego, California); Krishna Kumar Gnanasekaran (Mississauga, California); Kate Eshelman (Alexandria, Virginia); Achala N.D. Punchi Hewage (Lawrence, Kansas); Scott Lovell (Shawnee, Kansas); Anabel Soldano (Baton Rouge, Louisiana) |
| ABSTRACT | The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I: wherein R1-5 are defined herein. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502975 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4035 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117958 | Berger et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shelley L. Berger (Wayne, Pennsylvania); Philipp Mews (New York, New York); Jeffrey Winkler (Wynnewood, Pennsylvania); Andrew Glass (Philadelphia, Pennsylvania); Gabor Egervari (Philadelphia, Pennsylvania) |
| ABSTRACT | The present invention provides compositions and methods for inhibiting ACSS2 for modulating histone acetylation or for treating or preventing a neurological disease or disorder. |
| FILED | Thursday, September 26, 2019 |
| APPL NO | 17/277759 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/498 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117965 | Griffin et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE SCRIPPS RESEARCH INSTITUTE (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick R. Griffin (Jupiter, Florida); Mi Ra Chang (Jupiter, Florida); Jason Fisherman (Brookline, Massachusetts); Peter Suzman (Newton, Massachusetts) |
| ABSTRACT | Disclosed herein are methods and uses of the polypharmacological modulator SR1903 and related compounds for inhibiting triggering receptor expressed on myeloid cells-1 (TREM-1) and treating diseases and conditions that are related to or mediated by TREM-1, such as inflammatory diseases, autoimmune diseases, metabolic disorders, and castration resistant prostate cancer (CRPC). |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/491834 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117967 | Jiang et al. |
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| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina); The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong-hui Jiang (Durham, North Carolina); Yuna Kim (Durham, North Carolina); Hyeong-min Lee (Durham, North Carolina); Jian Jin (Durham, North Carolina); Bryan L. Roth (Durham, North Carolina) |
| ABSTRACT | The invention provides pharmaceutical compositions and methods of use thereof for treating Prader-Willi syndrome. More specifically, the invention provides pharmaceutical compositions that when administered inhibit the G9a driven methylation of histone H3 lysine 9. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533347 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/517 (20130101) Original (OR) Class A61K 31/551 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Heterocyclic Compounds C07D 401/02 (20130101) C07D 401/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117968 | MEYERS et al. |
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| FUNDED BY |
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| APPLICANT(S) | Saint Louis University (St. Louis, Missouri); Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marvin J. MEYERS (Wentzville, Missouri); Megh SINGH (Ellisville, Missouri); Christina L. STALLINGS (St. Louis, Missouri); Leslie A. WEISS (San Diego, California); Scott WILDMAN (Madison, Wisconsin); Stacy D. ARNETT (St. Louis, Missouri) |
| ABSTRACT | The present disclosure provides compounds, methods, and compositions which may be used to treat tuberculosis. In some embodiments, these compounds and compositions have a bactericidal property against Mycobacterium tuberculosis (Mtb). Methods of employing such agents are also provided. |
| FILED | Tuesday, July 17, 2018 |
| APPL NO | 17/266703 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/44 (20130101) A61K 31/47 (20130101) A61K 31/133 (20130101) A61K 31/175 (20130101) A61K 31/198 (20130101) A61K 31/422 (20130101) A61K 31/438 (20130101) A61K 31/496 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/593 (20130101) A61K 31/4409 (20130101) A61K 31/4709 (20130101) A61K 31/4965 (20130101) A61K 31/5377 (20130101) A61K 31/5383 (20130101) A61K 31/5415 (20130101) A61K 31/7036 (20130101) A61K 31/7048 (20130101) A61K 38/12 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/06 (20180101) Heterocyclic Compounds C07D 491/048 (20130101) C07D 495/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117987 | ELIAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jack A. ELIAS (Providence, Rhode Island); Chun Geun LEE (Woodbridge, Connecticut); Chang-Min LEE (Warwick, Rhode Island) |
| ABSTRACT | Described herein are methods of treating fibrosis and fibrotic diseases with certain aminoglycosides, e.g., kasugamycin derivatives thereof. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571295 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7034 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118002 | Nociari et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Cornell University (Ithaca, New York) |
| INVENTOR(S) | Marcelo M. Nociari (Ithaca, New York); Enrique Rodriguez Boulan (Ithaca, New York) |
| ABSTRACT | The present disclosure relates generally to compositions and methods for the treatment of eye diseases (e.g., retinopathies), and more particularly, to treatment of eye diseases associated with retinal cell lipofuscin accumulation. |
| FILED | Tuesday, March 03, 2020 |
| APPL NO | 17/436023 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/724 (20130101) Original (OR) Class A61K 47/26 (20130101) A61K 47/40 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118008 | DUNHAM et al. |
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| FUNDED BY |
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| APPLICANT(S) | Hemanext Inc. (Lexington, Massachusetts) |
| ASSIGNEE(S) | Hemanext Inc. (Lexington, Massachusetts) |
| INVENTOR(S) | Andrew DUNHAM (Lexington, Massachusetts); Tatsuro YOSHIDA (Lexington, Massachusetts) |
| ABSTRACT | Methods for the reversal of hemorrhagic shock or hemorrhagic trauma. Methods for restoring mean arterial pressure to a normal range and reducing trauma adverse risks in a patient through the administration of oxygen reduced blood compositions. |
| FILED | Friday, June 04, 2021 |
| APPL NO | 17/339283 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/14 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118017 | Kass et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David A. Kass (Baltimore, Maryland); Mark J. Ranek (Baltimore, Maryland); Kristen Kokkonen (Baltimore, Maryland); Brittany Dunkerly-Eyring (Baltimore, Maryland) |
| ABSTRACT | Provided herein are engineered tuberous sclerosis complex 2 (TSC2) polypeptides in which the ability of a residue corresponding to a serine residue in a wild type TSC2 polypeptide to be phosphorylated is altered. In some cases, an engineered TSC2 polypeptide cannot be phosphorylated (e.g., by substituting a serine residue with an alanine residue). In some cases, an engineered TSC2 polypeptide can act as if it is constitutively phosphorylated (e.g., by substituting a serine residue with a glutamic acid residue). Also provided herein are engineered immune cells including altered TSC2 polypeptides or including nucleic acid sequences encoding altered TSC2 polypeptides, and methods of making and using such engineered immune cells. |
| FILED | Thursday, January 09, 2020 |
| APPL NO | 17/421249 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/00 (20180101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118022 | Persaud et al. |
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| FUNDED BY |
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| APPLICANT(S) | Stephen Persaud (St. Louis, Missouri); John DiPersio (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Stephen Persaud (St. Louis, Missouri); John DiPersio (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of conditioning agents for use in allogeneic hematopoietic stem cell transplantation. An aspect of the present disclosure provides for a method of treating a subject or inhibiting alloreactivity in the host-versus-graft direction comprising administering a combination of conditioning agents comprising an anti-body-drug conjugate (ADC) and a JAK1/JAK2 inhibitor for use in allogeneic hematopoietic stem cell transplantation in an amount sufficient to permit engraftment of allogeneic bone marrow. In some embodiments, the JAK inhibitor is selected from baricitinib. In some embodiments, the method comprises administering a cancer therapeutic. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/504656 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) A61K 35/28 (20130101) Original (OR) Class A61K 39/001 (20130101) A61K 47/6803 (20170801) A61K 2035/122 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118024 | Frank et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia); Schepens Eye Research Institute (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia); Schepens Eye Research Institute (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Markus H. Frank (Cambridge, Massachusetts); Natasha Y. Frank (Cambridge, Massachusetts); Bruce Ksander (Boston, Massachusetts); Paraskevi Evi Kolovou (Boston, Massachusetts) |
| ABSTRACT | Various aspects and embodiments of the present invention are directed to methods of treating a subject having an ocular condition, methods of isolating ocular stem cells, methods of selecting and/or producing ocular grafts for transplantation, and methods of promoting ocular cell regeneration as well as to grafts and preparations containing isolated ocular stem cells characterized by the expression of ABCB5 on their cell surface. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/486855 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0051 (20130101) A61K 35/30 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3834 (20130101) A61L 27/3839 (20130101) A61L 2430/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101) C12N 5/0623 (20130101) C12N 5/0668 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118051 | Opal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Puneet Opal (Oak Park, Illinois); Samuel I. Stupp (Chicago, Illinois) |
| ABSTRACT | Provided herein are self-assembling peptide amphiphiles (PAs) comprising a bioactive vascular endothelial growth factor (VEGF) peptide, nanofibers displaying VEGF PAs, and methods of treatment or prevention of the polyglutamine disease Spinocerebellar Ataxia Type 1 (SCA1) and other neurodegenerative diseases therewith. In particular embodiments, a VEGF peptide delivery platform is provided in which the mechanical properties of the nanofiber material are tunable by altering the ratio of bioactive PA to structural PAs (e.g., acidic or basic PAs lacking a bioactive epitope). |
| FILED | Friday, November 08, 2019 |
| APPL NO | 17/292265 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/14 (20130101) A61K 38/1866 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118054 | Burnett, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John C. Burnett, JR. (Rochester, Minnesota); Nina Dzhoyashvili (Rochester, Minnesota) |
| ABSTRACT | Materials and methods for treating hypertension (including resistant hypertension) with a combination of an M-atrial natriuretic peptide (MANP) and a diuretic agent (e.g., furosemide) are described herein. |
| FILED | Friday, November 08, 2019 |
| APPL NO | 17/292083 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/341 (20130101) A61K 38/2242 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/12 (20180101) A61P 13/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118060 | Villeda et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saul A. Villeda (San Francisco, California); Alana Horowitz (San Francisco, California); Xuelai Fan (San Francisco, California) |
| ABSTRACT | Provided herein are glycosylphosphatidylinositol-specific phospholipase D1 (Gpld1) polypeptide compositions and methods for improving cognitive function and/or motor impairment in an individual comprising treatment with a Gpld1 polypeptide. |
| FILED | Tuesday, February 04, 2020 |
| APPL NO | 17/428009 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/465 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118069 | Okada et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hideho Okada (Mill Valley, California); Yafei Hou (Palo Alto, California) |
| ABSTRACT | Peptides that generate an immune response to glioma-related H3.3 proteins and methods of their use are provided. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512573 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/03 (20130101) A61K 38/17 (20130101) A61K 38/19 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 2039/80 (20180801) A61K 2039/5158 (20130101) Peptides C07K 14/47 (20130101) C07K 14/4748 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) G01N 33/5014 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118085 | Dowling et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Medical Center Corporation (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Children's Medical Center Corporation (Boston, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | David J. Dowling (Brighton, Massachusetts); Ofer Levy (Cambridge, Massachusetts); Francesco Borriello (Jamaica Plain, Massachusetts); David A. Scott (Newton, Massachusetts); Spencer E. Brightman (San Diego, California) |
| ABSTRACT | Provided herein are Toll-like receptor 2 (TLR2) agonists for use in enhancing human immune response and/or as adjuvants in vaccines. The TLR2 agonists include thiophenes, imidazoles, or phenyl-containing compounds, which may be compounds of Formulae (I), (II), (III), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein are used as enhancers of an immune response (e.g., innate and/or adaptive immune response), and are useful in treating and/or preventing a disease, as adjuvants in a vaccine for the disease, (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein. |
| FILED | Friday, July 26, 2019 |
| APPL NO | 17/263515 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/381 (20130101) A61K 31/438 (20130101) A61K 31/496 (20130101) A61K 31/739 (20130101) A61K 31/4025 (20130101) A61K 31/4535 (20130101) A61K 39/39 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/572 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118087 | ROTOLO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sloan Kettering Institute for Cancer Research (, None) |
| ASSIGNEE(S) | Sloan Kettering Institute for Cancer Research (, None) |
| INVENTOR(S) | Jimmy Andrew ROTOLO (Port Washington, New York); Richard N. KOLESNICK (New York, New York) |
| ABSTRACT | It has been discovered that administering therapeutically effective amounts of an antibiotic that kills Gram-negative bacteria, together with an anti-ceramide antibody or anti-ceramide mimetic, treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTL)-induced killing and/or by damage to endothelial microvasculature, including Radiation GI syndrome, GvHD disease, inflammatory diseases and autoimmune diseases. |
| FILED | Friday, July 17, 2020 |
| APPL NO | 16/932204 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/496 (20130101) A61K 31/4709 (20130101) A61K 39/39533 (20130101) Original (OR) Class A61K 39/39541 (20130101) A61K 45/06 (20130101) Peptides C07K 16/18 (20130101) C07K 16/44 (20130101) C07K 2317/24 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118094 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong WANG (State College, Pennsylvania); Peng SHI (State College, Pennsylvania) |
| ABSTRACT | The present invention relates generally to methods of generating a biomimetic cell wall (BCW) on a target surface, compositions comprising the BCW, and methods of use of the compositions, including biomedical applications of the BCW coated compositions. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 17/432821 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/22 (20130101) A61K 47/26 (20130101) Original (OR) Class A61K 47/28 (20130101) A61K 47/42 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118101 | TROY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carol M. TROY (Hastings-on-Hudson, New York); Maria I. AVRUTSKY (Bronx, New York) |
| ABSTRACT | The present disclosure relates to a method of preventing or decreasing inflammation in a patient comprising administering to the patient in need thereof an effective amount of a caspase-9 signaling pathway inhibitor. The caspase-9 signaling pathway inhibitor may include a peptide caspase-9 inhibitor and/or may be conjugated to a cell-penetrating peptide. The present disclosure further includes pharmaceutical compositions including a caspase-9 signaling pathway inhibitor. The disclosure further relates to the use of such compositions in a method of treating inflammation of the retina associated with retinal vein occlusion, diabetic macular edema, retinal detachment, ocular trauma, retinitis pigmentosa, age-related macular degeneration, uveitis, a retinal degenerative disease, glaucoma, Multiple sclerosis, Behcets, Lupus, Systemic sarcoidosis, Central serous chorioretinopathy, Leber's Hereditary Optic Neuropathy, Leigh Syndrome, Stargardt, retinitis pigmentosa, Best disease, or birdshot retinopathy. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/515202 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/57 (20130101) A61K 38/1709 (20130101) A61K 47/64 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118106 | Bradbury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michelle S. Bradbury (New York, New York); Ulrich Wiesner (Ithaca, New York); Michael Overholtzer (Glen Ridge, New Jersey); Howard Scher (Tenafly, New Jersey); Kai Ma (Ithaca, New York) |
| ABSTRACT | Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/566015 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/22 (20130101) A61K 47/60 (20170801) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118107 | Xue et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yunlu Xue (Boston, Massachusetts); Constance L. Cepko (Newton, Massachusetts) |
| ABSTRACT | The present invention provides compositions, e.g., pharmaceutical compositions, which include a recombinant adeno-associated viral (AAV) expression construct, AAV vectors, AAV particles, and methods of treating a subject having a degenerative ocular disorder, e.g., retinitis pigmentosa. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/428670 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/17 (20130101) A61K 48/005 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) A61P 39/06 (20180101) Peptides C07K 14/47 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118117 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhaoda Zhang (Methuen, Massachusetts); Junfeng Wang (Malden, Massachusetts); Timothy M. Shoup (Franklin, Massachusetts); Anna-Liisa Brownell (Salem, Massachusetts) |
| ABSTRACT | The present application provides picolinamide compounds that can be used as allosteric positron emission tomography (“PET”) imaging probes. Methods of using these compounds for treating a neurodegenerative disease are also provided. |
| FILED | Wednesday, January 08, 2020 |
| APPL NO | 17/421239 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0455 (20130101) Original (OR) Class General Methods of Organic Chemistry; Apparatus Therefor C07B 59/002 (20130101) C07B 2200/05 (20130101) Heterocyclic Compounds C07D 213/81 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118179 | Rosinko et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beta Bionics, Inc. (Irvine, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael J. Rosinko (Las Vegas, Nevada); Edward R. Damiano (Acton, Massachusetts); David Chi-Wai Lim (Irvine, California); Firas H. El-Khatib (Allston, Massachusetts); Justin P. Brown (Tustin, California); Bryan Dale Knodel (Flagstaff, Arizona) |
| ABSTRACT | Systems and methods are disclosed herein for updating an application controlling an ambulatory medical device such that application updates can be identified, downloaded and installed without interrupting therapy provided by the ambulatory medical device to a subject. The ambulatory medical device may receive an indication that an update to an application executing on the ambulatory insulin pump is available, establish a communication connection to a host computing system configured to host the application update, and download the application update. The disclosed systems and methods can determine an execution time of an installation and install the downloaded application update without interrupting therapy provided by the ambulatory medical device to the subject. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/482281 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/142 (20130101) A61M 5/172 (20130101) Original (OR) Class A61M 5/1723 (20130101) A61M 5/14244 (20130101) A61M 5/14248 (20130101) A61M 5/16831 (20130101) A61M 2205/18 (20130101) A61M 2205/52 (20130101) A61M 2205/3553 (20130101) A61M 2230/201 (20130101) Electric Digital Data Processing G06F 3/04847 (20130101) G06F 3/04883 (20130101) G06F 8/61 (20130101) G06F 8/65 (20130101) G06F 8/656 (20180201) G06F 21/31 (20130101) G06F 21/84 (20130101) G06F 21/305 (20130101) G06F 21/6245 (20130101) Signalling or Calling Systems; Order Telegraphs; Alarm Systems G08B 21/18 (20130101) G08B 21/0453 (20130101) G08B 25/00 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/17 (20180101) G16H 40/40 (20180101) G16H 40/60 (20180101) G16H 40/67 (20180101) G16H 50/30 (20180101) G16H 80/00 (20180101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/30 (20130101) H04L 9/088 (20130101) H04L 63/101 (20130101) H04L 67/34 (20130101) Wireless Communication Networks H04W 76/10 (20180201) H04W 76/14 (20180201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118246 | Hansen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marlan Hansen (Solon, Iowa); Christopher Kaufmann (Iowa City, Iowa) |
| ABSTRACT | The present embodiment is an implantable device capable of controlling cochlear implant electrode insertion and positioning. The embodiment uses an implanted mechanical positioning unit to advance position and monitor an electrode array. The device can be controlled via an external controller to reposition or advance an electrode array at any point after implantation with no surgical re-intervention. A cochlear implant electrode array whose position can be advanced and modified over time to best fit a patient's evolving hearing pattern would improve functional outcomes and significantly expand the candidacy range for cochlear implantation to include patients with substantial residual hearing. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561260 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3468 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0541 (20130101) Original (OR) Class A61N 1/36038 (20170801) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/09 (20130101) Transmission H04B 5/0037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118269 | Carter et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Calvin S. Carter (Iowa City, Iowa); Sunny C. Huang (Iowa City, Iowa); Charles C. Searby (Iowa City, Iowa); Michael J. Miller (Iowa City, Iowa); Val C. Sheffield (Iowa City, Iowa) |
| ABSTRACT | An example may deliver a therapy by delivering energy to tissue. A method may include delivering energy to the tissue by providing a magnetic field in a first direction to the tissue using a magnetic field system including a magnetic field source to produce the magnetic field, wherein the magnetic field produced by the magnetic field source includes a magnetic field produced by at least one of a permanent magnet, a temporary magnet or electric current flow through a conductor, and providing an electric field in a second direction to the tissue using an electric field system including an electric field source to produce the electric field, wherein the second direction is non-parallel to the first direction. The method may further include detecting biomarker(s) within at least one of a redox system and a metabolic system to monitor efficacy of the therapy and/or calibrate or adjust the therapy. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/503082 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/063 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 2/02 (20130101) A61N 2/004 (20130101) A61N 2/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118452 | Demirci et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Utkan Demirci (Stanford, California); Mehmet Ozgun Ozen (Palo Alto, California); Naside Gozde Durmus (Stanford, California); Rakhi Gupta (Cupertino, California); Sharon Pitteri (Palo Alto, California); Fernando Jose Garcia Marques (Redwood City, California) |
| ABSTRACT | An extracellular vesicle-containing sample can be processed using a device for isolating one or more subpopulations of the extracellular vesicles. The extracellular vesicle-containing sample is flowed through a flow chamber of the device under an applied fluid pressure, in which the device has one or more inlets and two or more outlets in fluid communication with one another via the flow chamber. The device has one or more filters in the flow chamber between the inlet(s) and at least one of the outlet(s). The extracellular vesicle-containing sample is flowed through the filter(s) in the flow chamber to sort the extracellular vesicles of extracellular vesicle-containing sample by size into two or more subpopulations of the extracellular vesicles. At least one of the subpopulations that has been sorted flows out of a corresponding one of the outlets. Surface marker-based exosome sorting using magnetic beads may be used after the size-based exosome isolation. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/504947 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/13 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502753 (20130101) Original (OR) Class B01L 3/502761 (20130101) B01L 2300/0681 (20130101) B01L 2300/0819 (20130101) B01L 2300/0864 (20130101) B01L 2300/0877 (20130101) B01L 2300/0896 (20130101) B01L 2400/043 (20130101) B01L 2400/0436 (20130101) B01L 2400/0487 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/01 (20130101) B03C 1/288 (20130101) B03C 2201/18 (20130101) B03C 2201/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119344 | WOSTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick M. WOSTER (Charleston, South Carolina); Joy E. KIRKPATRICK (Charleston, South Carolina) |
| ABSTRACT | The invention relates to KDM4B inhibitors, compositions comprising an effective amount of KDM4B inhibitors and methods for treating inflammatory diseases and disorders. |
| FILED | Thursday, June 04, 2020 |
| APPL NO | 16/956871 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 235/38 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119352 | Cai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianfeng Cai (Tampa, Florida); Peng Teng (Tampa, Florida); Alekhya Nimmagadda (Tampa, Florida) |
| ABSTRACT | Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516546 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4178 (20130101) A61K 38/12 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 233/46 (20130101) Original (OR) Class C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119374 | Tsukamoto et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Takashi Tsukamoto (Ellicott City, Maryland); Niyada Hin (Laurel, Maryland); Ondrej Stepanek (Baltimore, Maryland); Barbara Slusher (Kingsville, Maryland); Camilo Rojas (Baltimore, Maryland); Ajit G. Thomas (Baltimore, Maryland) |
| ABSTRACT | Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer or HIV-1, are provided. |
| FILED | Wednesday, January 29, 2020 |
| APPL NO | 17/422670 |
| CURRENT CPC | Heterocyclic Compounds C07D 233/64 (20130101) C07D 405/14 (20130101) C07D 409/04 (20130101) Original (OR) Class C07D 409/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119377 | Stoltz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian M. Stoltz (San Marino, California); Alexander W. Sun (Irvine, California); Stephan N. Hess (Pasadena, California); Carina I. Jette (Pasadena, California); Irina Geibel (Bad Zwischenahn, Germany); Shoshana Bachman (Las Vegas, Nevada); Masaki Hayashi (Kanagawa, Japan); Hideki Shimizu (Hyogo, Japan); Jeremy B. Morgan (Wilmington, North Carolina); Shunya Sakurai (Kyoto, Japan); Zachary P. Sercel (Pasadena, California) |
| ABSTRACT | Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of α-substituted lactams, such as γ-lactams. The use of various electrophiles and ligands are described, and result in the construction of α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee). |
| FILED | Friday, December 31, 2021 |
| APPL NO | 17/566919 |
| CURRENT CPC | Heterocyclic Compounds C07D 207/26 (20130101) C07D 239/06 (20130101) C07D 241/08 (20130101) C07D 243/08 (20130101) C07D 413/14 (20130101) Original (OR) Class C07D 507/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119384 | Krogstad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul Krogstad (Los Angeles, California); Michael E. Jung (Los Angeles, California); Jun Zuo (Los Angeles, California); Yanpeng Xing (Los Angeles, California) |
| ABSTRACT | The present technology provides compounds according to Formulas (I), (II), or (III) useful in inhibiting an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus in a cell and/or treating subjects suffering from an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus. |
| FILED | Tuesday, June 08, 2021 |
| APPL NO | 17/342182 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) A61P 31/14 (20180101) Heterocyclic Compounds C07D 471/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119399 | Stockwell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brent R. Stockwell (New York, New York); Michael Stokes (New York, New York); Andrea Califano (New York, New York); Arie Zask (New York, New York) |
| ABSTRACT | The present disclosure provides, inter alia, scaffolds and compounds having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and one or more compounds according to the present disclosure. Further provided are methods for treating or ameliorating the effects of a cancer in a subject, methods for selectively killing a cancer cell, methods of modulating mTORC1/2 signaling activity in a cell, methods of modulating the activity of a Master Regulator for MycN in a subject having MycN-amplified neuroblastoma (MycNAMP NBL), methods of selectively treating or ameliorating effects of a cancer in a subject in need thereof, and platforms and methods for identifying a compound that induces degradation of a cancer-related protein. Also provided are kits comprising a compound or a pharmaceutical composition according to the present disclosure. Methods for treating cancers and methods for modulating MYC Master Regulators using other compounds are also provided. |
| FILED | Friday, June 11, 2021 |
| APPL NO | 17/345688 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 311/36 (20130101) C07D 491/052 (20130101) Original (OR) Class C07D 493/04 (20130101) C07D 493/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119402 | Bugni et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy Bugni (Madison, Wisconsin); Fan Zhang (Madison, Wisconsin); Douglas R. Braun (Mount Horeb, Wisconsin); David Andes (Verona, Wisconsin); Miao Zhao (Madison, Wisconsin) |
| ABSTRACT | Turbinmicin, an isolated compound of Formula (I) or IA is provided. Turbinomycin compounds of Formula (II) or (IIA) are also provided. A compound isolated from a bacterial species from the sea squirt, Ecteinascidia turbinate, and having a chemical formula of C34H29NO11 is also provided. Compositions including turbinmicin and turbinmicin compounds, such as pharmaceutical compositions including effective amounts of turbinmicin or turbinomicing compounds for treating fungal infections such as Candida and Aspergillus, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with turbinmicin, turbinmicin compounds and compositions thereof are disclosed. |
| FILED | Friday, December 27, 2019 |
| APPL NO | 17/420117 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Heterocyclic Compounds C07D 491/16 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119416 | Bradner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | James E. Bradner (Weston, Massachusetts); Jun Qi (Sharon, Massachusetts); Minoru Tanaka (Boston, Massachusetts); Justin M. Roberts (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V), and (VI). Some bromodomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds. |
| FILED | Tuesday, December 15, 2020 |
| APPL NO | 17/122258 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/551 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 15/16 (20180101) Heterocyclic Compounds C07D 519/00 (20130101) Original (OR) Class Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119428 | BAZIN-LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium) |
| ASSIGNEE(S) | GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, Belgium) |
| INVENTOR(S) | Helene G. BAZIN-LEE (Hamilton, Montana); Laura S. BESS (Hamilton, Montana); David A. JOHNSON (Hamilton, Montana) |
| ABSTRACT | The present invention relates to a process for phospholipidation of imidazoquinolines and oxoadenines. More particularly, the present invention relates to a high-yielding and scalable procedure for the phospholipidation of imidazoquinolines and oxoadenines which obviates the need to isolate unstable phosphoramidite intermediates. This process may be used for the phospholipidation of toll-like receptor 7 (TLR7)—active and toll-like receptor (TLR8)—active imidazoquinolines and oxoadenines. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/566247 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/10 (20130101) C07F 9/65583 (20130101) Original (OR) Class C07F 9/65616 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119438 | Rhijn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women's Hospital, Inc. (Boston, Massachusetts); Rijksuniversiteit Groningen (Groningen, Netherlands) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ildiko Van Rhijn (Amsterdam, Netherlands); Adriaan J. Minnaard (Groningen, None); D. Branch Moody (W. Roxbury, Massachusetts); Tan-Yun Cheng (Ashland, Massachusetts); Jeffrey Buter (Groningen, Netherlands) |
| ABSTRACT | Provided herein are compositions of trehalose phospholipids and uses thereof, e.g., compounds and compositions comprising 6,6′-diphosphatidyltrehalose (diPT) and analogs thereof with modifications of the diPT chemical scaffold, that bind and agonize Mincle, and the use thereof as adjuvants. |
| FILED | Wednesday, January 08, 2020 |
| APPL NO | 17/421312 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0002 (20130101) A61K 39/002 (20130101) A61K 39/02 (20130101) A61K 39/39 (20130101) A61K 45/06 (20130101) A61K 2039/55566 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 11/04 (20130101) Original (OR) Class Peptides C07K 16/44 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 2405/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119444 | COSFORD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sanford Burnham Prebys Medical Discovery Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas David Peter COSFORD (San Diego, California); Mitchell Dennis VAMOS (San Diego, California) |
| ABSTRACT | Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds. |
| FILED | Thursday, July 29, 2021 |
| APPL NO | 17/389171 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Heterocyclic Compounds C07D 487/04 (20130101) C07D 487/14 (20130101) C07D 498/04 (20130101) C07D 498/10 (20130101) C07D 513/04 (20130101) Peptides C07K 5/0806 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119446 | BAZAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisons of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicolas G. BAZAN (New Orleans, Louisiana); Jorgelina M. CALANDRIA (New Orleans, Louisiana); Ludmila S. BELAYEV (Metairie, Louisiana) |
| ABSTRACT | The invention is directed to methods for identifying and treating neuronal injury or neurodegeneration. |
| FILED | Friday, November 15, 2019 |
| APPL NO | 17/294769 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/06 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6863 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119451 | Cheng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kun Cheng (Kansas City, Missouri); Hao Liu (Kansas City, Missouri); John Fetse (Kansas City, Missouri); Umar-Farouk Mamani (Kansas City, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kun Cheng (Overland Park, Kansas); Hao Liu (Rockville, Maryland); John Fetse (Mission, Kansas); Umar-Farouk Mamani (Mission, Kansas) |
| ABSTRACT | Polypeptides and compositions having the polypeptides. Methods for treating cancer utilizing polypeptides and compositions having the polypeptides. The polypeptides can bind to human PD-L1 protein. The polypeptides can block the PD-1/PD-L1 interaction. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/507301 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119454 | Marshall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CALDER BIOSCIENCES INC. (NEW YORK, New York); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (BETHESDA, Maryland) |
| ASSIGNEE(S) | CALDER BIOSCIENCES INC. (NEW YORK, New York); THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (BETHESDA, Maryland) |
| INVENTOR(S) | Christopher Patrick Marshall (New York, New York); Jason Scott McLellan (Norwich, Vermont); Peter Joseph Alff (New York, New York); Claudio Bertuccioli (New York, New York); Roberto Mariani (San Diego, California) |
| ABSTRACT | In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same. |
| FILED | Thursday, May 27, 2021 |
| APPL NO | 17/332901 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/155 (20130101) A61K 2039/525 (20130101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 2760/18534 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119469 | Harris |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samantha P. Harris (Tucson, Arizona) |
| ABSTRACT | Methods and compositions for rapidly replacing cMyBP-C in sarcomeres featuring the creation of Spy-C mice, which are mice genetically engineered to express cMyBP-C with a protease recognition site and SpyTag peptide introduced into the cMyBP-C gene. In permeabilized myocytes from the Spy-C mice, the cMyBP-C protein can be cleaved at the protease recognition site, and the N-Terminus of cMyBP-C can be removed while the C-terminus remains anchored to the thick filament. A new peptide featuring the SpyCatcher sequence can be covalently bonded to the remaining portion of cMyBP-C, thereby creating a modified cMyBP-C protein. The methods and compositions of the present invention allow for the reconstitution of full-length cMyBP-C at the precise position of native cMyBP-C in the sarcomere and allow for a variety of modifications to be introduced to cMyBP-C in situ. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/559865 |
| CURRENT CPC | Peptides C07K 14/4716 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119475 | Corey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | David P. Corey (Cambridge, Massachusetts); Casey A. Maguire (Arlington, Massachusetts); Killian S. Hanlon (Cambridge, Massachusetts); Maryna V. Ivanchenko (Cambridge, Massachusetts) |
| ABSTRACT | Aspects of the disclosure relate to compositions and methods for treating hereditary hearing loss and/or vision loss, for example, due to Usher syndrome, Type 3A. In some embodiments, the disclosure provides a recombinant adeno-associated virus comprising: (i) an AAV-S capsid protein, and (ii) an isolated nucleic acid comprising a transgene (e.g., a transgene for expressing a clarin-1 protein). The present disclosure also provides methods of treating hereditary hearing loss and/or vision loss (e.g., Usher Syndrome, Type 3A) using the same. |
| FILED | Tuesday, September 14, 2021 |
| APPL NO | 17/474535 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) Peptides C07K 14/705 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) C12N 2800/90 (20130101) C12N 2840/105 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119489 | GUSSONI |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Emanuela GUSSONI (Boston, Massachusetts) |
| ABSTRACT | The present invention features compositions and methods featuring CD82 for treating muscular dystrophies and related disorders. In one aspect, the invention provides a method of preserving or increasing muscle function in a dystrophic cell, the method involving contacting the cell with a CD82 polypeptide or a polynucleotide encoding a CD82 polypeptide. |
| FILED | Monday, November 25, 2019 |
| APPL NO | 17/425272 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/573 (20130101) A61K 31/585 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 21/00 (20180101) Peptides C07K 14/70596 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) G01N 2333/70596 (20130101) G01N 2800/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119502 | Rowley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ann and Robert H. Lurie Children's Hospital of Chicago (Chicago, Illinois); Loyola University Chicago (Maywood, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne H. Rowley (Oak Park, Illinois); Standford L. Shulman (Evanston, Illinois); Susan C. Baker (Elmhurst, Illinois) |
| ABSTRACT | The present disclosure provides monoclonal antibodies that target intracytoplasmic inclusion bodies and/or hepacivirus C NS4A and methods for their use. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 17/310832 |
| CURRENT CPC | Peptides C07K 16/109 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/34 (20130101) C07K 2317/40 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5767 (20130101) G01N 33/6893 (20130101) G01N 2800/328 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119504 | Nussenzweig et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michel Nussenzweig (New York, New York); Randal R. Ketchem (Snohomish, Washington); Christine C. Siska (Seattle, Washington); Alison J. Gillespie (Seattle, Washington); Rutilio H. Clark (Bainbridge Island, Washington); Bruce A. Kerwin (Bainbridge Island, Washington) |
| ABSTRACT | The present disclosure provides optimized broadly-neutralizing anti-HIV antibodies, having modified light chain variable regions and/or heavy chain variable regions leading to improved biophysical characteristics. The present disclosure also provides methods for producing these anti-HIV antibodies and methods of use thereof. |
| FILED | Thursday, September 12, 2019 |
| APPL NO | 17/275310 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/18 (20180101) Peptides C07K 16/1045 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119532 | Kipnis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jonathan Kipnis (Charlottesville, Virginia); Antoine Louveau (Charlottesville, Virginia) |
| ABSTRACT | Methods of treating, preventing, inhibiting, delaying the onset of, or ameliorating a neurological immunity disorder can include administering an effective amount of a compound comprising an antibody or antigen binding fragment of an antibody to a subject in need of treatment, prevention, inhibition, delay of onset, or amelioration of a neurological immunity disorder and/or nervous system injury. The antibody or the antigen binding fragment of an antibody binds specifically to CD49a. |
| FILED | Tuesday, January 14, 2020 |
| APPL NO | 17/422659 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/2842 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119772 | McCauley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S HOSPITAL MEDICAL CENTER (Cincinnati, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Heather McCauley (Cincinnati, Ohio); James Macormack Wells (Cincinnati, Ohio) |
| ABSTRACT | Described herein are methods for treating a malabsorptive disorder. The malabsorptive disorder may be, in certain aspects, characterized by malabsorption of macronutrients in the intestine, and may include, for example, a disease selected from one or more of enteric anendocrinosis, short gut syndrome, enteric pathogen infection, malnutrition, genetic causes of malabsorption, Celiac disease, malabsorptive diarrhea, and inflammatory bowel. Such methods may include administration of peptide YY (PYY) to an individual in need thereof. Also described are medicaments for carrying out the disclosed methods. |
| FILED | Tuesday, January 14, 2020 |
| APPL NO | 17/421908 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0679 (20130101) Original (OR) Class C12N 2506/02 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119775 | Gradinaru et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viviana Gradinaru (Pasadena, California); Nicholas C. Flytzanis (Thousand Oaks, California); Nicholas S. Goeden (Thousand Oaks, California) |
| ABSTRACT | Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms showing increased specificity and efficiency of viral transduction in targeted cell types such as the brain and lung. The rAAV compositions described herein also have tropisms showing decreased specificity and decreased efficiency of viral transduction in an off-target cell type such as the liver. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. Upon systemic delivery to a subject, the rAAV is capable of increased specificity and increased transduction of the transgene in a target cell-type, as compared to a parental or reference AAV. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/503972 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2750/14071 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119777 | Castor et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trevor Percival Castor (Arlington, Massachusetts); Vasudevacharya Jayarama (Framingham, Massachusetts) |
| ASSIGNEE(S) | Trevor P. Castor (Woburn, Massachusetts) |
| INVENTOR(S) | Trevor Percival Castor (Arlington, Massachusetts); Vasudevacharya Jayarama (Framingham, Massachusetts) |
| ABSTRACT | The present invention is directed to methods, kits and compositions for inactivating viral agents in or on articles including blood-based products and feature a light sensitive compound selected from the group consisting of hypericin, pseudohypericin and hypocrellin, a group of light producing compounds comprising luciferase, luciferin, ATP and CDP Star, and emission enhancers or quenchers selected from the group consisting of as Sapphire, Emerald, Ruby, Sapphire-II and Emerald-II. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506649 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0215 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2770/24163 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119785 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Alexis Christine Komor (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing enzymes or domains, are provided. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/408306 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/50 (20130101) A61K 38/465 (20130101) A61K 47/61 (20170801) Peptides C07K 2319/00 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) C12N 9/6472 (20130101) C12N 15/01 (20130101) C12N 15/102 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 301/00 (20130101) C12Y 301/22 (20130101) C12Y 304/22062 (20130101) C12Y 305/04 (20130101) C12Y 305/04001 (20130101) C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119793 | Chatterjee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Trustees of Boston College (Chestnut Hill, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Abhishek Chatterjee (Lexington, Massachusetts); James S. Italia (Charlestown, Massachusetts) |
| ABSTRACT | An engineered tyrosyl-tRNA synthetase/tRNA pair that co-translationally incorporates O-sulfotyrosine in response to UAG codons in E. coli and mammalian cells is described herein. This platform enables recombinant expression of eukaryotic proteins homogeneously sulfated at chosen sites. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/594570 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Enzymes C12Y 601/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119794 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liwu LI (Blacksburg, Virginia); Shuo GENG (Blacksburg, Virginia); Yao ZHANG (Blacksburg, Virginia) |
| ABSTRACT | Described herein are embodiments of chemically modified neutrophils and pharmaceutical formulations thereof. Also described herein are 4-phenylbutyrate pharmaceutical formulations. Also described herein are methods of chemically modifying neutrophils. Also described herein are treatments for non-resolving inflammation and/or related diseases or conditions, including but not limited to atherosclerosis, cardiovascular disease, stroke, myocardial infarction, neurological disease, and/or a symptom thereof in a subject in need thereof. |
| FILED | Monday, December 23, 2019 |
| APPL NO | 17/419274 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/192 (20130101) A61K 35/15 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) A61P 29/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/01 (20130101) Original (OR) Class C12N 15/85 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119797 | MELOSH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas A. MELOSH (Menlo Park, California); Yuhong CAO (Palo Alto, California); Karl Martin HJORT (Lund, Sweden); Amanda JONSSON (Stanford, California) |
| ABSTRACT | Methods and apparatuses to non-destructively and periodically sample a small quantity of intracellular proteins and mRNA from the same single cell or cells for an extended period of time. Specifically, describe herein are non-perturbative methods for time-resolved, longitudinal extraction and quantitative measurement of intracellular proteins and nucleic acids from a variety of cell types using systems including nanostraws. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/460129 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 33/04 (20130101) C12M 35/02 (20130101) C12M 41/38 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) C12N 15/1003 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119813 | Marbán et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eduardo Marbán (Los Angeles, California); Ke Cheng (Los Angeles, California); Ahmed Ibrahim (Los Angeles, California) |
| ABSTRACT | Several embodiments relate to methods of repairing and/or regenerating damaged or diseased tissue comprising administering to the damaged or diseased tissues compositions comprising exosomes. In several embodiments, the exosomes comprise one or more microRNA that result in alterations in gene or protein expression, which in tum result in improved cell or tissue viability and/or function. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/537005 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/7105 (20130101) A61K 35/34 (20130101) A61K 47/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0657 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119817 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeannie T. Lee (Cambridge, Massachusetts); Jing Zhao (San Diego, California); Kavitha Sarma (Waltham, Massachusetts); Mark Borowsky (Needham, Massachusetts); Toshiro Kendrick Ohsumi (Cambridge, Massachusetts) |
| ABSTRACT | This invention relates to long non-coding RNAs (lncRNAs), libraries of those lncRNAs that bind chromatin modifiers, such as Polycomb Repressive Complex 2, inhibitory nucleic acids and methods and compositions for targeting lncRNAs. |
| FILED | Thursday, June 17, 2021 |
| APPL NO | 17/350018 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) A61K 31/713 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1135 (20130101) C12N 15/1136 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/113 (20130101) C12N 2310/141 (20130101) C12N 2310/314 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/346 (20130101) C12N 2310/3181 (20130101) C12N 2310/3231 (20130101) C12N 2310/3233 (20130101) C12N 2320/30 (20130101) C12N 2320/32 (20130101) C12N 2330/31 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 1/6881 (20130101) C12Q 1/6886 (20130101) C12Q 2600/136 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) Enzymes C12Y 201/01043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119820 | McNally et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois); NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth McNally (Oak Park, Illinois); Eugene Wyatt (Chicago, Illinois) |
| ABSTRACT | The invention is directed to one or more antisense polynucleotides and their use in pharmaceutical compositions in a strategy to induce exon skipping in the γ-sarcoglycan gene in patients suffering from Limb-Girdle Muscular Dystrophy-2C (LGM-D2C) or in patients at risk of such a disease. The invention also provides methods of preventing or treating muscular dystrophy, e.g., LGMD2C, by exon skipping in the gamma sarcoglycan gene using antisense polynucleotides. Accordingly, in some aspects the invention provides an isolated antisense oligonucleotide, wherein the oligonucleotide specifically hybridizes to an exon target region of a γ-sarcoglycan RNA. In another aspect, the the invention provides a method of inducing exon-skipping of a gamma sarcoglycan RNA, comprising delivering an antisense oligonucleotide or a composition to a cell. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571302 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/31 (20130101) C12N 2310/315 (20130101) C12N 2310/321 (20130101) C12N 2310/346 (20130101) C12N 2310/351 (20130101) C12N 2310/3181 (20130101) C12N 2310/3233 (20130101) C12N 2310/3513 (20130101) C12N 2310/3521 (20130101) C12N 2320/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119825 | Cornish et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Virginia Cornish (New York, New York); James Brisbois (Cambridge, Massachusetts); Sonja Billerbeck (Groningen, Netherlands); Miguel Jimenez (Winthrop, Massachusetts) |
| ABSTRACT | The present disclosure relates to intercellular signaling between genetically-engineered cells and, more specifically, to a scalable peptide-GPCR intercellular signaling system. The present disclosure provides an intercellular signaling system that includes at least two cells that have been genetically-engineered to communicate with each other, methods of use and kits thereof. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514648 |
| CURRENT CPC | Peptides C07K 14/38 (20130101) C07K 14/39 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 15/81 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119839 | Perez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel R. Perez (Olney, Maryland); Hongjun Chen (Hyattsville, Maryland); Yibin Cai (Hyattsville, Maryland); Lindomar Jose Pena (College Park, Maryland); Matthew Angel (Greenbelt, Maryland) |
| ABSTRACT | Disclosed are compositions and methods comprising one or more recombinant influenza viruses. Recombinant influenza viruses with mutated polymerases and/or rearranged genomes are disclosed. Constructs comprising different influenza nucleic acid sequences are also provided. Methods of inducing protecting immunity with the recombinant influenza viruses are disclosed. Also disclosed are methods of plasmid-free production of influenza virus comprising amplicons comprising one or more of influenza genes. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333904 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) A61K 39/145 (20130101) A61K 2039/70 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119868 | Disney |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew D. Disney (Jupiter, Florida) |
| ABSTRACT | Many RNAs cause disease, however RNA is rarely exploited as a small molecule drug target. Disclosed herein are methods for identifying privileged RNA motif-small molecule interactions to enable the rational design of compounds that modulate RNA biology starting from only sequence. A massive, library-versus-library screen was completed that probed over 50 million binding events between RNA motifs and small molecules. The resulting data provide a rich encyclopedia of small molecule-RNA recognition patterns, defining chemotypes and RNA motifs that confer selective, avid binding. The resulting interaction maps were mined against the entire viral genome of hepatitis C virus (HCV). A small molecule was identified that avidly bound RNA motifs present in the HCV3′ untranslated region and inhibited viral replication while having no effect on host cells. Collectively, this investigation represents the first whole genome pattern recognition between small molecules and RNA folds. |
| FILED | Wednesday, September 11, 2019 |
| APPL NO | 17/275537 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6811 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119885 | Horvath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Stefan Horvath (Los Angeles, California); Ake Tzu-Hui Lu (Los Angeles, California) |
| ABSTRACT | The disclosure provides seven DNAm-based estimators of plasma protein levels including those of plasminogen activation inhibitor 1 (PAI-1) and growth differentiation factor 15 (GDF15). The predictor of lifespan, DNAm GrimAge (in units of years), is a composite biomarker based on the seven DNAm surrogate markers and a DNAm-based estimator of smoking pack-years. These novel DNAm based biomarkers show the expected relationship with lifestyle factors (including healthy diet or educational attainment) and clinical biomarkers. Overall, these DNAm based biomarkers are expected to find many useful applications including human anti-aging studies. |
| FILED | Wednesday, October 09, 2019 |
| APPL NO | 17/282318 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/154 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119891 | DAVIS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melissa B. DAVIS (New York, New York) |
| ABSTRACT | Methods for prognosticating if an individual afflicted with a malignant tumor is likely to respond favorably to immunotherapy comprising testing for the presence or absence of D ARC expression in the tumor, and if no DARC expression is detected, identifying the individual as not being suitable for immunotherapy, and optionally administering an anti-cancer therapy other than immunotherapy to the individual, or if DARC expression is detected, then identifying the individual as being suitable for immunotherapy, and optionally administering immunotherapy or any other anti-cancer therapy to the individual. |
| FILED | Thursday, February 06, 2020 |
| APPL NO | 17/428219 |
| CURRENT CPC | Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119898 | De Giorgi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Dept. of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Valeria De Giorgi (Bethesda, Maryland); Robert D. Allison (Bethesda, Maryland); Harvey J. Alter (Bethesda, Maryland) |
| ABSTRACT | Probe sets capable of detecting pathogen nucleic acids in a sample are described. The probe set can be provided on a solid support, such as a microarray. Methods of detecting pathogen nucleic acids in a sample using the probe set are also provided. In some examples, the probes and methods are capable of detecting one or more RNA viruses, one or more DNA viruses, one or more bacterial nucleic acids, and/or one or more protozoan nucleic acids in a sample. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 17/425228 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/701 (20130101) Original (OR) Class C12Q 2600/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120731 | Tal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michal Caspi Tal (Cupertino, California); Lara Myers (Hamilton, Montana); Kim J. HasenKrug (Victor, Montana); Ying Ying Yiu (Concord, California); Irving L. Weissman (Stanford, California) |
| ABSTRACT | Prolonged exposure of CD8+ T cells to antigenic stimulation leads to a state of diminished function, termed exhaustion; during exhaustion there is a subset of functional CD8+ T cells defined by surface expression of SIRP(alpha) protein. On SIRP+ CD8+ T cells, expression of coinhibitmy receptors is counterbalanced by expression of co-stimulatory receptors and it is only these SIRP+ cells that actively proliferate, transcribe IFNg and show cytolytic activity. Therapeutic blockade of PD-L1 or other inhibitory receptors to reinvigorate exhausted CD8+ T cells expands the cytotoxic subset of SIRP+ CD8+ T cells. |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 17/425224 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0638 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/505 (20130101) Original (OR) Class G01N 2333/70596 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120736 | Young et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A. Young (Boston, Massachusetts); Phillip A. Sharp (Newton, Massachusetts); Arup K. Chakraborty (Lexington, Massachusetts); Alessandra Dall'Agnese (Cambridge, Massachusetts); Krishna Shrinivas (Cambridge, Massachusetts); Brian J. Abraham (Cambridge, Massachusetts); Ann Boija (Somerville, Massachusetts); Eliot Coffey (Cambridge, Massachusetts); Daniel S. Day (Redwood City, California); Yang E. Guo (Somerville, Massachusetts); Nancy M. Hannett (Medford, Massachusetts); Tong Ihn Lee (Cambridge, Massachusetts); Charles H. Li (Waban, Massachusetts); Isaac Klein (Milton, Massachusetts); John C. Manteiga (Boston, Massachusetts); Benjamin R. Sabari (Watertown, Massachusetts); Jurian Schuijers (Somerville, Massachusetts); Abraham S. Weintraub (Cambridge, Massachusetts); Alicia V. Zamudio (Cambridge, Massachusetts); Lena K. Afeyan (Boston, Massachusetts); Ozgur Oksuz (Worcester, Massachusetts); Jonathan E. Henninger (Somerville, Massachusetts) |
| ABSTRACT | Described herein are compositions and methods for modulating gene regulation by modulating condensate formation, composition, maintenance, dissolution and regulation. |
| FILED | Friday, March 22, 2019 |
| APPL NO | 17/040967 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/535 (20130101) Original (OR) Class G01N 33/5005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120745 | Grewal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Queensland (St.Lucia, Australia); Seattle Children's Hospital dba Seattle Children's Research Institute (Seattle, Washington) |
| ASSIGNEE(S) | The University of Queensland (St. Lucia, Queensland, Australia); Seattle Children's Hospital dba Seattle Children's Research Institute (818 Stewart Street, Suite 603, Washington) |
| INVENTOR(S) | Yadveer Grewal (Logan City, Australia); Gerard A. Cangelosi (Seattle, Washington); Muhammad J.A. Shiddiky (Saint Lucia, Australia); Matt Trau (Balmoral, Australia) |
| ABSTRACT | The present disclosure relates to biofragment compositions that comprise bioparticle fragments and at least one heterologous antigen-binding molecule. In some embodiments, the biofragment is typically derived from a larger, intact bioparticle that express the at least one heterologous antigen-binding molecule at the surface, and the biofragment has increased solubility to facilitate assays for antigen detection. The disclosure also relates the related methods of using and making the biofragment compositions, as well as systems and devices implementing the biofragment compositions. In some embodiments, the related methods, systems and devices do not require additional detection reagents, such as animal derived detection antibodies. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458958 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/566 (20130101) Original (OR) Class G01N 33/5432 (20130101) G01N 33/5438 (20130101) G01N 33/56911 (20130101) G01N 33/56961 (20130101) G01N 33/56966 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120761 | Sarwal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Minnie Sarwal (San Francisco, California); Joshua Yang (San Francisco, California) |
| ABSTRACT | The disclosure describes a comprehensive metabolome analysis of urine samples that identified panels of metabolite markers for diagnosis and monitoring of alloimmune injury, acute rejection, and BK virus nephropathy. The disclosure provides non-invasive ways to monitor the status of transplanted kidneys by monitoring the presence of defined metabolite panels over a period of time. The metabolite panels of the disclosure can distinguish the between kidney injuries of distinct etiology with high sensitivity and specificity. |
| FILED | Friday, January 17, 2020 |
| APPL NO | 17/423868 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6848 (20130101) G01N 33/6893 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/245 (20130101) G01N 2800/347 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/20 (20190201) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120921 | MORSE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown Universtiy (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore F. MORSE (Providence, Rhode Island); Angus Ian KINGON (Warren, Rhode Island); Nicholas Alexander MOSTOVYCH (Silver Spring, Maryland) |
| ABSTRACT | An X-ray detector includes a scintillation plate and sensors, the scintillation plate having a glass capillary array with scintillation material filling, wherein the glass capillary array with scintillation material filling is mated with two high volume, low cost, CMOS sensors, and wherein the glass capillary array is arranged diagonally to mate with active parts of the two high volume, low cost, CMOS sensors. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/503761 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/4233 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/04 (20130101) Measurement of Nuclear or X-radiation G01T 1/20185 (20200501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120923 | GOLDAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amirhossein GOLDAN (Stony Brook, New York); Andrew LABELLA (New Rochelle, New York); Wei ZHAO (East Setauket, New York); Anthony LUBINSKY (Port Jefferson Station, New York) |
| ABSTRACT | Provided area device for detecting sub-atomic particles and method of fabrication thereof. The device includes a plurality of scintillators, a detector provided on a first end of the plurality of scintillators and a prismatoid provided on a second end of the plurality of scintillators. The prismatoid redirects light between adjacent scintillators of the plurality of scintillators. |
| FILED | Wednesday, January 08, 2020 |
| APPL NO | 17/417552 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/1644 (20130101) G01T 1/2002 (20130101) G01T 1/2985 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122250 | Besson et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pierre Alain Besson (Evanston, Illinois); Sarah Kathleen Bandt (Evanston, Illinois) |
| ABSTRACT | Described here are systems and method for predicting clinically relevant brain features using geometric deep learning techniques, such as may be implemented with graph convolutional neural networks or autoencoder networks that are applied to graph representations of brain surface morphology derived from medical images. As an example, graph convolutional neural networks can be applied to brain surface morphology data derived from magnetic resonance images (e.g., T1-weighted) using surface extraction techniques in order to predict brain feature data. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/505465 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/4088 (20130101) A61B 5/4842 (20130101) A61B 5/4848 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122486 | Dixon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Rivanna Medical LLC (Charlottesville, Virginia) |
| ASSIGNEE(S) | Rivanna Medical LLC (Charlottesville, Virginia) |
| INVENTOR(S) | Adam Joseph Dixon (Charlottesville, Virginia); Frank William Mauldin, JR. (Charlottesville, Virginia) |
| ABSTRACT | An ultrasound training model which exhibits optically clear soft tissue-mimicking materials that are simultaneously acoustically scattering and self-healing to needle punctures. An exemplary embodiment is disclosed that comprises an embedded bone-mimicking spine model and a dual-purpose lid that may be used as a friction surface mat. Various embodiments of the training model materials are disclosed. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501431 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/587 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 23/286 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122696 | Huang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yanmei Huang (Chestnut Hill, Massachusetts); Isabel Fernandez Escapa (Brooklyn, New York); Katherine Lemon (Houston, Texas); Floyd E. Dewhirst (Medfield, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yanmei Huang (Chestnut Hill, Massachusetts); Isabel Fernandez Escapa (Brooklyn, New York); Katherine Lemon (Houston, Texas); Floyd E. Dewhirst (Medfield, Massachusetts) |
| ABSTRACT | Systems, methods, and computer program products for generating an enhanced set of sequences for taxonomical classification are disclosed. In various embodiments, a plurality of reference sequences are received. Each of the plurality of reference sequences corresponds to a taxonomical classification. A label corresponding to at least one of the reference sequences is assigned to each of a plurality of supplemental sequences. Each of the plurality of supplemental sequences and each of the plurality of reference sequences are truncated to a region of interest to thereby generate a truncated set of sequences. Similarity is measured between pairs of truncated sequences in the truncated set of sequences to determine whether the similarity is above a predetermined threshold. An intermediate taxonomical label is assigned to the pair of truncated sequences in the truncated set of sequences when the similarity is above the predetermined threshold to thereby generate an enhanced set of sequences. |
| FILED | Friday, September 27, 2019 |
| APPL NO | 17/311610 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1065 (20130101) C12N 15/1089 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 10/00 (20190201) G16B 40/20 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220117759 | Lanier, JR. et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory R. Lanier, JR. (Manchester, New Hampshire); N. Christopher Perry (Manchester, New Hampshire); Andrew P. Pascoe (Windham, New Hampshire); Dirk A. van der Merwe (Canterbury, New Hampshire) |
| ABSTRACT | A prosthetic device control apparatus includes at least one sensor worn by a user. The sensor(s) determines a user's movement. A control module is in communication with the sensor(s). The control module communicates movement information to a prosthetic. A method for controlling a prosthetic device includes sensing a user's movement, communicating the movement through a control module to a prosthetic device; and controlling the movement of a prosthetic device. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/460920 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1036 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/583 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118221 | FRANKLIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Prytime Medical Devices, Inc. (Boerne, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Curtis J. FRANKLIN (Lakewood, Colorado); David SPENCER (Boerne, Texas); Todd J. KRUMMENACHER (Lakewood, Colorado) |
| ABSTRACT | An occlusion catheter system includes a proximal hub having an inflation connection port and an inflation pathway. An inflation catheter member is connected to the proximal hub and has an inflation lumen. A stiffener member defines a longitudinal axis. The proximal end of the stiffener member is connected to the proximal hub. The stiffener member extends through a portion of the inflation lumen. An occlusion balloon has a proximal balloon end and a distal balloon end. A distal catheter member is positioned substantially on the longitudinal axis and is connected to the distal end of the stiffener member. An atraumatic tip is positioned on a distal end of the distal catheter member. The atraumatic tip has a substantially circular profile in a relaxed configuration. A pressure sensor is connected to the occlusion catheter system distally relative to the occlusion balloon and is connected to a processor by electrical wiring. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563669 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/12036 (20130101) A61B 2017/00017 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 25/007 (20130101) A61M 25/008 (20130101) A61M 25/0068 (20130101) Original (OR) Class A61M 25/0074 (20130101) A61M 25/104 (20130101) A61M 25/1002 (20130101) A61M 25/1006 (20130101) A61M 25/10182 (20131105) A61M 2025/0002 (20130101) A61M 2025/1052 (20130101) A61M 2025/1086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118446 | Swami et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Nathan Swami (Charlottesville, Virginia); Walter Varhue (Glen Allen, Virginia); George Christ (Crozet, Virginia); Shayn Peirce-Cottler (Charlottesville, Virginia); Aditya Rane (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nathan Swami (Charlottesville, Virginia); Walter Varhue (Glen Allen, Virginia); George Christ (Crozet, Virginia); Shayn Peirce-Cottler (Charlottesville, Virginia); Aditya Rane (Charlottesville, Virginia) |
| ABSTRACT | A microfluidic device can include a superstructure defining a microfluidic channel therein and a first hydrogel bonded to the microfluidic channel to define a perfusable channel therein, the first hydrogel including cells embedded therein or thereon. The microfluidic device can optionally include a second hydrogel bonded to the microfluidic channel or to the hydrogel. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/451256 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2300/069 (20130101) B01L 2300/161 (20130101) Apparatus for Enzymology or Microbiology; C12M 21/08 (20130101) C12M 23/16 (20130101) C12M 25/14 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0697 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118501 | Ren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huaqing Ren (Santa Clara, California); Jiaxi Xie (Evanston, Illinois); Shuheng Liao (Evanston, Illinois); Dohyun Leem (Evanston, Illinois); Jian Cao (Wilmette, Illinois); Kornel F. Ehmann (Evanston, Illinois) |
| ABSTRACT | Novel systems and methods for an incremental forming process to manufacture a product are disclosed herein. The system and method generally involves continuously modifying the toolpath in real-time based upon the forming force of the forming tool compared to a predicted springback error established offline from a series of simplified simulations. The system and method disclosed herein are effective to form products with complex geometries and minimizes the costs and time requirements associated with prior art techniques. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/430452 |
| CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 31/005 (20130101) Original (OR) Class Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/404 (20130101) G05B 2219/45234 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119244 | Starman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | LaVern A. Starman (Dayton, Ohio); John PK Walton (Troy, Ohio); Harris J. Hall (Yellow Springs, Ohio) |
| ABSTRACT | An actuator element of a MEMS device is provided, which is fabricated using surface micromachining on a substrate. An insulating layer having a first portion contacts the substrate while a second portion is separated from the substrate by a gap. A metallic layer contacts the insulating layer having a first portion contacting the first portion of the insulating layer and a second portion contacting the second portion of the insulating layer. The second portion of the metallic layer is prestressed. Alternately, the actuator element includes a first insulating layer separated from the substrate by a gap. A metallic layer has a first portion contacting the substrate and a second portion contacting the insulating layer. A second insulating layer contacts a portion of the second portion of the metallic layer opposite the first insulating layer, where the second insulating layer is prestressed. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/564330 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0043 (20130101) Original (OR) Class B81B 2201/032 (20130101) B81B 2201/042 (20130101) B81B 2203/053 (20130101) B81B 2203/058 (20130101) Optical Elements, Systems, or Apparatus G02B 26/0833 (20130101) G02B 26/0841 (20130101) G02B 26/0866 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119466 | El-Samad et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hana El-Samad (San Francisco, California); Andrew Ng (San Francisco, California) |
| ABSTRACT | Provided are molecular feedback circuits as well as nucleic acids encoding such molecular feedback circuits and cells genetically modified with the subject molecular feedback circuits. Methods of modulating signaling of a signaling pathway of a cell using molecular feedback circuits and methods of treating a subject for a condition by administering a cell containing a nucleic acid that encodes a molecular feedback circuit are also provided. Aspects of the molecular feedback circuits of the present disclosure include a signaling protein, of a signaling pathway, that includes a latent deactivation domain. Such circuits may include a regulatory sequence that is responsive to an output of the signaling pathway and is operably linked to a nucleic acid encoding a switch polypeptide that, when expressed, triggers the deactivation domain to deactivate the signaling molecule. |
| FILED | Monday, January 06, 2020 |
| APPL NO | 17/419234 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/4705 (20130101) Original (OR) Class C07K 2319/095 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119467 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Baker (Seattle, Washington); Scott Boyken (Seattle, Washington); Hana El-Samad (San Francisco, California); Marc Lajoie (Seattle, Washington); Robert Langan (Seattle, Washington); Andrew Ng (San Francisco, California) |
| ABSTRACT | Provided are molecular feedback circuits employing caged-degrons. Aspects of such circuits include the use of a caged-degron to modulate the output of a signaling pathway in a feedback-controlled manner. Also provided are nucleic acids encoding molecular circuits and cells containing such nucleic acids. Methods of using caged-degron-based molecular feedback circuits are also provided, including e.g., methods of modulating a signaling pathway of a cell that include genetically modifying the cell with a caged-degron-based molecular feedback circuit. |
| FILED | Monday, January 06, 2020 |
| APPL NO | 17/419236 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/4705 (20130101) Original (OR) Class C07K 2319/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119651 | WEBSTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NDSU RESEARCH FOUNDATION (Fargo, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean C. WEBSTER (Fargo, North Dakota); Jackson BENDA (Fargo, North Dakota) |
| ABSTRACT | The invention relates to a curable coating composition comprising at least one surface modifying amphiphilic additive and at least one amphiphilic siloxane-polyurethane coating composition. The invention also relates to methods of making and using the curable coating composition of the invention. The invention also relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the use of the curable coating composition of the invention. |
| FILED | Tuesday, April 13, 2021 |
| APPL NO | 17/229091 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/12 (20130101) C08G 18/61 (20130101) C08G 18/755 (20130101) C08G 18/4833 (20130101) C08G 18/6225 (20130101) C08G 77/12 (20130101) C08G 77/16 (20130101) C08G 77/46 (20130101) C08G 77/388 (20130101) C08G 2150/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/1637 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119775 | Gradinaru et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Viviana Gradinaru (Pasadena, California); Nicholas C. Flytzanis (Thousand Oaks, California); Nicholas S. Goeden (Thousand Oaks, California) |
| ABSTRACT | Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms showing increased specificity and efficiency of viral transduction in targeted cell types such as the brain and lung. The rAAV compositions described herein also have tropisms showing decreased specificity and decreased efficiency of viral transduction in an off-target cell type such as the liver. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. Upon systemic delivery to a subject, the rAAV is capable of increased specificity and increased transduction of the transgene in a target cell-type, as compared to a parental or reference AAV. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/503972 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2750/14071 (20130101) C12N 2750/14121 (20130101) C12N 2750/14122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119785 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Cambridge, Massachusetts); Alexis Christine Komor (Cambridge, Massachusetts) |
| ABSTRACT | Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing enzymes or domains, are provided. |
| FILED | Friday, August 20, 2021 |
| APPL NO | 17/408306 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/50 (20130101) A61K 38/465 (20130101) A61K 47/61 (20170801) Peptides C07K 2319/00 (20130101) C07K 2319/80 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) Original (OR) Class C12N 9/78 (20130101) C12N 9/6472 (20130101) C12N 15/01 (20130101) C12N 15/102 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 301/00 (20130101) C12Y 301/22 (20130101) C12Y 304/22062 (20130101) C12Y 305/04 (20130101) C12Y 305/04001 (20130101) C12Y 305/04004 (20130101) C12Y 305/04005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119825 | Cornish et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Virginia Cornish (New York, New York); James Brisbois (Cambridge, Massachusetts); Sonja Billerbeck (Groningen, Netherlands); Miguel Jimenez (Winthrop, Massachusetts) |
| ABSTRACT | The present disclosure relates to intercellular signaling between genetically-engineered cells and, more specifically, to a scalable peptide-GPCR intercellular signaling system. The present disclosure provides an intercellular signaling system that includes at least two cells that have been genetically-engineered to communicate with each other, methods of use and kits thereof. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514648 |
| CURRENT CPC | Peptides C07K 14/38 (20130101) C07K 14/39 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 15/81 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119982 | Herrington et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Voxel Innovations, Inc. (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Herrington (Raleigh, North Carolina); Eric Rountree (Raleigh, North Carolina) |
| ABSTRACT | A technique of removing material from metal parts referred to as OPECM and a corresponding OPECM processing machine are disclosed. A tool electrode is manufactured for removing material from a target workpiece, and the workpiece and tool electrode are fixed into a processing machine that imparts an oscillatory motion path or profile and applies a voltage through a flowing electrolyte solution. The disclosed technique and processing machine removes material from the surface of the target workpiece through proximal surface dissolution as the workpiece and tool electrode are brought within proximity of one another. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/565817 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/62 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/20 (20200101) B33Y 80/00 (20141201) Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/16 (20130101) C25F 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120043 | Zavattieri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Pablo Zavattieri (West Lafayette, Indiana); Scott Hartford (South Bend, Indiana); Kristiaan Hector (Shelby Twp, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pablo Zavattieri (West Lafayette, Indiana); Scott Hartford (South Bend, Indiana); Kristiaan Hector (Shelby Twp, Michigan) |
| ABSTRACT | A flexible mat system, including a plurality of base platforms, each respective base platform having a first pattern of phase transforming columns and voids extending from a respective flat member, and a plurality of plane-engaging runway platforms, each respective plane-engaging runway platform having a second, reversed pattern of phase transforming columns and voids extending from a respective flat member such that each respective plane-engaging runway platform is lockingly engagable to a respective base platform to yield a landing segment with parallel top and bottom flat members. Each respective base platform is an aluminum/steel composite. Each respective phase transforming column is further comprised of a plurality of stacked operationally connected phase transforming cellular members. Each respective cell further comprises six hexagonally spaced support members defining six hexagonally arrayed sides, with two opposing sides define x-shaped struts extending between adjacent support members. Remaining sides define parallel struts extending between adjacent support members. Each respective phase transforming cellular member can shift from a first stable configuration to a second stable configuration in response to an applied load. |
| FILED | Wednesday, July 21, 2021 |
| APPL NO | 17/382039 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 3/12 (20130101) B32B 15/012 (20130101) B32B 2307/54 (20130101) B32B 2471/04 (20130101) Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/36 (20130101) Construction Of, or Surfaces For, Roads, Sports Grounds, or the Like; Machines or Auxiliary Tools for Construction or Repair E01C 5/18 (20130101) E01C 9/083 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120358 | Hielkema et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | GE Aviation Systems LLC (Grand Rapids, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jerry Dean Hielkema (Rockton, Illinois); Kevin P. Hallisey (Ave Maria, Florida); Tyler Ray Permenter (Loves Park, Illinois); Julian Alexander Opificius (Elk River, Minnesota) |
| ABSTRACT | A valve assembly for use in a bleed air system or any other pneumatic, hydraulic, mechanical, magnetic, or electrical system that includes a valve assembly. The value assembly includes a valve housing, a valve member, a pressure regulator, and a position sensor assembly. The valve housing includes an inlet and outlet that is angled from the inlet. The valve member slides between a first position wherein the valve member is closed and abuts a seat within the valve housing and a second position wherein the valve member is in a position a distance away from the seat. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/076360 |
| CURRENT CPC | Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 27/02 (20130101) F16K 31/363 (20130101) Original (OR) Class F16K 37/0041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120916 | Phan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rockwell Collins, Inc. (Cedar Rapids, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huan T. Phan (Cedar Rapids, Iowa); Gary A. McGraw (Cedar Rapids, Iowa); Michael J. Armatys (Cedar Rapids, Iowa) |
| ABSTRACT | A system and for determining precision navigation solutions decorrelates GPS carrier-phase ambiguities derived from multiple-source GPS information via Least-squares AMBiguity Decorrelation Adjustment (LAMBDA) algorithms. The set of decorrelated floating-point ambiguities is used to compute protection levels and the probability of almost fix (PAF), or the probability that the partial almost-fix solution corresponding to the decorrelated ambiguities is within the region of correctly-fixed or low-error almost-fixed ambiguities. While the PAF remains below threshold and the protection levels remain below alert levels, the optimal navigation solution (floating-point, partial almost-fix, or fully fixed) is generated by fixing the decorrelated ambiguities are one at a time in the LAMBDA domain and replacing the appropriate carrier-phase ambiguities with the corresponding fixed ambiguities, reverting to the last solution if PAF reaches the threshold or if protection levels reach the alert levels. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/564906 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 19/07 (20130101) G01S 19/41 (20130101) Original (OR) Class G01S 19/44 (20130101) G01S 19/55 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120976 | Palone et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Thomas Palone (Rochester, New York); Stefan F. Preble (Pittsford, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Palone (Rochester, New York); Stefan F. Preble (Pittsford, New York) |
| ABSTRACT | Systems, devices and methods useful for aligning and attaching optical fibers and optical fiber ribbons to a photonic integrated circuit. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/424789 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/3652 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121002 | Kar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aravinda Kar (Orlando, Florida); Chandraika Sugrim (Saint Augustine, Florida) |
| ABSTRACT | An optical device may include an optical body having first and second opposing sides, and passageways extending between the first and second opposing sides. The optical device includes a mirror layer carried by the optical body adjacent the second opposing side, thermally conductive fingers extending in the passageways, and a heatsink carried by the optical body adjacent the first opposing side and coupled to the thermally conductive fingers. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/451376 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 7/028 (20130101) G02B 7/1815 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121084 | Bowers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John E. Bowers (Santa Barbara, California); Lin Chang (Goleta, California) |
| ABSTRACT | An integrated laser/non-linear device includes a semiconductor/dielectric substrate, a nonlinear device fabricated on the semiconductor/dielectric substrate and a pump laser fabricated on the same semiconductor/dielectric substrate. |
| FILED | Friday, October 01, 2021 |
| APPL NO | 17/492381 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/365 (20130101) G02F 1/3503 (20210101) Original (OR) Class G02F 2203/56 (20130101) Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 5/12 (20130101) H01S 5/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121381 | Brewer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Disclosed in some examples, are methods, systems, devices, and machine readable mediums that store instructions for programmable atomic transactions in a memory of the programmable atomic unit prior to execution of the programmable atomic transaction. The memory in some examples may be an instruction RAM. The memory in some examples may be partitioned into partitions of a fixed size that stores a same number of instructions. Each programmable atomic transaction may use one or more contiguously located instruction partitions. By loading the instructions ahead of time, the instructions are ready for execution when the transaction is requested. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/074802 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/061 (20130101) G06F 3/0644 (20130101) Original (OR) Class G06F 3/0679 (20130101) G06F 12/0253 (20130101) G06F 13/1668 (20130101) G06F 2212/7205 (20130101) G06F 2213/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121394 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Disclosed in some examples, are methods, systems, machine readable mediums, memory devices, and memory controllers that detect memory hotspots. The system keeps a count of a number of memory accesses that were queued waiting for another memory access to that address to finish. The number of memory accesses may be compared to a hotspot criteria to determine one or more memory hotspots. These hotspots may be sent to a processor, which may store the memory hotspots in a file which may be provided to an administrator. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/074755 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0619 (20130101) G06F 3/0653 (20130101) G06F 3/0659 (20130101) Original (OR) Class G06F 3/0679 (20130101) G06F 12/0253 (20130101) G06F 2212/7205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121395 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Devices and techniques for communicating a programmable atomic operator to a memory controller are described herein. A memory controller can receive a memory request and extract a command indicator that indicates a programmable atomic operator (PAO) command from the memory request. The memory controller can then extract a PAO index from the request and invoke the PAO based on the PAO index. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/074937 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/0604 (20130101) G06F 3/0644 (20130101) G06F 3/0659 (20130101) Original (OR) Class G06F 3/0679 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121452 | Walker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dean E. Walker (Allen, Texas); Tony Brewer (Plano, Texas); Chris Baronne (Allen, Texas) |
| ABSTRACT | Devices and techniques for on-demand programmable atomic kernel loading are described herein. A programmable atomic unit (PAU) of a memory controller can receive an invocation of a programmable atomic operator by the memory controller. The PAU can then perform a verification on a programmable atomic operator partition for the programmable atomic operator. Here, the programmable atomic operator partition is located in a memory of the PAU. The PAU can then signal a trap in response to the verification indicating that the programmable atomic operator partition is not prepared. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/075055 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4403 (20130101) Original (OR) Class G06F 12/1458 (20130101) G06F 2212/1052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121474 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Disclosed in some examples, are methods, systems, computing devices, and machine readable mediums which define an instruction for a programmable atomic transaction that is executed as the last instruction and that terminates the executing thread, waits for all outstanding store operations to finish, clears the programmable atomic lock, and sends a completion response back to the issuing process. This guarantees that the programmable atomic lock is cleared when the transaction completes. By coupling thread termination with clearing the lock bit, this guarantees that the thread cannot terminate without clearing the lock. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/074770 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/466 (20130101) Original (OR) Class G06F 9/524 (20130101) G06F 9/3004 (20130101) G06F 9/3009 (20130101) G06F 9/30101 (20130101) G06F 12/0246 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121476 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Chiplet systems may include a memory controller that has programmable atomic units that execute programmable atomic transactions. These instructions are stored in one or more memory partitions of memory in the programmable atomic unit. Since the programmable atomic unit executes programmable atomic transactions that are customized for various processes, and since the programmable atomic unit is a physical resource shared by multiple processes, the processes need a way of both loading the programmable atomic unit memory with instructions and a method of calling those instructions. Disclosed are methods, systems, and devices for registering, calling, and virtualizing programmable atomic transactions. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/074823 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/467 (20130101) Original (OR) Class G06F 9/5016 (20130101) G06F 9/5061 (20130101) G06F 13/1668 (20130101) G06F 2209/5011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121567 | Brewer et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas); Dean E. Walker (Allen, Texas); Chris Baronne (Allen, Texas) |
| ABSTRACT | Devices and techniques for memory access bounds checking for a programmable atomic operator are described herein. A processor can execute a programmable atomic operator with a base memory address. The processor can obtain a memory interleave size indicator corresponding to the programmable atomic operator and calculate a contiguous memory address range from the base memory address and the memory interleave size. The processor can then detect that a memory request from the programmable atomic operator is outside the contiguous memory address range and deny the memory request when it is outside of the contiguous memory address range and allow the memory request otherwise. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/075073 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0607 (20130101) Original (OR) Class G06F 2212/1012 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121584 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Disclosed in some examples are methods, systems, memory controllers, devices, and machine-readable mediums which minimize this stall time by returning a memory write acknowledgement once a write command has been selected by the memory controller input multiplexor rather than when the memory write command has been performed. Because the memory controller enforces an ordering to memory once the packet has been selected at an input multiplexor, ordering of prior and subsequent requests to the same address location are preserved and providing the response early allows the processor to continue its operations earlier without any harmful effects. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/074765 |
| CURRENT CPC | Electric Digital Data Processing G06F 13/161 (20130101) G06F 13/287 (20130101) G06F 13/1642 (20130101) G06F 13/1689 (20130101) Original (OR) Class G06F 15/7825 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121617 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Disclosed in some examples, are methods, systems, programmable atomic units, and machine-readable mediums that provide an exception as a response to the calling processor. That is, the programmable atomic unit will send a response to the calling processor. The calling processor will recognize that the exception has been raised and will handle the exception. Because the calling processor knows which process triggered the exception, the calling processor (e.g., the Operating System) can take appropriate action, such as terminating the calling process. The calling processor may be a same processor as that executing the programmable atomic transaction, or a different processor (e.g., on a different chiplet). |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/074779 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/4406 (20130101) G06F 15/82 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121738 | DeHon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andre Maurice DeHon (Philadelphia, Pennsylvania); Nicholas Edward Roessler (Philadelphia, Pennsylvania) |
| ABSTRACT | Methods, systems, and computer readable media for using metadata tag compression. A method occurs at a metadata processing system for enforcing security policies in a processor architecture. The method comprises: receiving, at the metadata processing system, a short tag associated with a word in memory; translating the short tag, using a tag map, into a long tag, wherein the short tag indicates a location of the long tag relative to an offset in the tag map and wherein the long tag indicates a memory location containing metadata associated with the word or an instruction; obtaining the metadata from the memory location; and determining, using the metadata, whether the word or the instruction violates a security policy. |
| FILED | Monday, March 01, 2021 |
| APPL NO | 17/188547 |
| CURRENT CPC | Electric Digital Data Processing G06F 12/0853 (20130101) G06F 12/0882 (20130101) G06F 21/54 (20130101) Original (OR) Class G06F 21/79 (20130101) G06F 21/554 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121911 | Cruz-Albrecht et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | HRL Laboratories, LLC (Malibu, California) |
| ASSIGNEE(S) | HRL Laboratories, LLC (Malibu, California) |
| INVENTOR(S) | Jose Cruz-Albrecht (Oak Park, California); Timothy Derosier (Colorado Springs, Colorado); Narayan Srinivasa (Portland, Oregon) |
| ABSTRACT | A reconfigurable neural circuit includes an array of processing nodes. Each processing node includes a single physical neuron circuit having only one input and an output, a single physical synapse circuit having a presynaptic input, and a single physical output coupled to the input of the neuron circuit, a weight memory for storing N synaptic conductance value or weights having an output coupled to the single physical synapse circuit, a single physical spike timing dependent plasticity (STDP) circuit having an output coupled to the weight memory, a first input coupled to the output of the neuron circuit, and a second input coupled to the presynaptic input, and interconnect circuitry connected to the presynaptic input and connected to the output of the single physical neuron circuit. The synapse circuit and the STDP circuit are each time multiplexed circuits. The interconnect circuitry in each respective processing node is coupled to the interconnect circuitry in each other processing node. |
| FILED | Thursday, June 20, 2019 |
| APPL NO | 16/447210 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 3/08 (20130101) G06N 3/063 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121925 | Amir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Arnon Amir (San Jose, California); Andrew Stephen Cassidy (San Jose, California); Nathaniel Joseph McClatchey (San Jose, California); Jun Sawada (Austin, Texas); Dharmendra S. Modha (San Jose, California); Rathinakumar Appuswamy (San Jose, California) |
| ABSTRACT | Chips supporting constant time program control of nested loops are provided. In various embodiments, a chip comprises at least one arithmetic-logic computing unit and a controller operatively coupled to the at least one arithmetic-logic computing unit. The controller is configured according to a program configuration, the program configuration comprising at least one inner loop and at least one outer loop. The controller is configured to cause the at least one arithmetic computing unit to execute a plurality of operations according to the program configuration. The controller is configured to maintain at least a first loop counter and a second loop counter, the first loop counter configured to count a number of executed iterations of the at least one outer loop, and the second loop counter configured to count a number of executed iterations of the at least one inner loop. The controller is configured to provide a first indication of whether the first loop counter corresponds to a last iteration and a second indication of whether the second loop counter corresponds to a last iteration. The controller is configured to alternatively increment, reset, or maintain each of the first and second loop counters according to the first and second indications. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/076180 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/10 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121951 | Cassidy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Stephen Cassidy (San Jose, California); Rathinakumar Appuswamy (San Jose, California); John Vernon Arthur (Mountain View, California); Jun Sawada (Austin, Texas); Dharmendra S. Modha (San Jose, California); Michael Vincent DeBole (Poughkeepsie, New York); Pallab Datta (San Jose, California); Tapan Kumar Nayak (San Jose, California) |
| ABSTRACT | Conflict-free, stall-free, broadcast networks on neural inference chips are provided. In various embodiments, a neural inference chip comprises a plurality of network nodes and a network on chip interconnecting the plurality of network nodes. The network comprises at least one pair of directional paths. The paths of each pair have opposite directions and a common end. The network is configured to accept data at any of the plurality of nodes. The network is configured to propagate data along a first of the pair of directional paths from a source node to the common end of the pair of directional paths and along a second of the pair of directional paths from the common end of the pair of directional paths to one or more destination node. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/076287 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/063 (20130101) G06N 3/084 (20130101) Original (OR) Class G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121978 | Woods et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Wayne Woods (Burlington, Massachusetts); Danna Rosenberg (Arlington, Massachusetts); Cyrus Hirjibehedin (Newton, Massachusetts); Donna-Ruth Yost (Action, Massachusetts); Justin Mallek (Burlington, Massachusetts); Andrew Kerman (Arlington, Massachusetts); Mollie Schwartz (Cambridge, Massachusetts); Jonilyn Yoder (Billerica, Massachusetts); William Oliver (Arlington, Massachusetts); Thomas Hazard (Cambridge, Massachusetts) |
| ABSTRACT | Qubit circuits having components formed deep in a substrate are described. The qubit circuits can be manufactured using existing integrated-circuit technologies. By forming components such as superconducting current loops, inductive, and/or capacitive components deep in the substrate, the footprint of the qubit circuit integrated within the substrate can be reduced. Additionally, coupling efficiency to and from the qubit can be improved and losses in the qubit circuit may be reduced. |
| FILED | Monday, January 04, 2021 |
| APPL NO | 17/140741 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 39/06 (20130101) H01L 39/045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121999 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (ARMONK, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shiqiang Wang (White Plains, New York); Supriyo Chakraborty (White Plains, New York); Nirmit V. Desai (Yorktown Heights, New York); Douglas M. Freimuth (New York, New York); Wei-Han Lee (White Plains, New York); Changchang Liu (White Plains, New York) |
| ABSTRACT | A computer implemented method includes distributing a plurality of prediction models, where each of a plurality of clients initially includes at least one associated prediction model from the plurality of prediction models, among all of the plurality of clients to provide each of the plurality of clients with each of the plurality of prediction models. The plurality of prediction models is evaluated on at least a portion of a local dataset resident on each of the plurality of clients to output a quantification indicating how each of the prediction models fit at least the portion of the local dataset of each of the plurality of clients. An ensemble model is generated by applying weights to each of the plurality of prediction models based on a value, a gradient, and a Hessian matrix of a user-defined objective. |
| FILED | Saturday, October 17, 2020 |
| APPL NO | 17/073341 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/04 (20130101) G06N 20/20 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122668 | Brewer |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Micron Technology, Inc. (Boise, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tony Brewer (Plano, Texas) |
| ABSTRACT | Devices and techniques for programmable atomic operator resource locking are described herein. A request for a programmable atomic operator (PAO) can be received at a memory controller that includes a programmable atomic unit (PAU). Here, the request includes an identifier for the PAO and a memory address. The memory addressed is processed to identify a lock value. A verification can be performed to determine that the lock value indicates that there is no lock corresponding to the memory address. Then, the lock value is set to indicate that there is now a lock corresponding to the memory address and the PAO is invoked based on the identifier for the PAO. In response to completion of the PAO, the lock value is set to indicate that there is no longer a lock corresponding to the memory address. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/075384 |
| CURRENT CPC | Static Stores G11C 16/08 (20130101) G11C 16/26 (20130101) G11C 16/102 (20130101) Original (OR) Class G11C 16/3459 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122843 | Vogt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York); The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Vogt (Ithaca, New York); Darrell G. Schlom (Ithaca, New York); Felix V. E. Hensling (Ithaca, New York); Kathy Azizie (Plainfield, New Jersey); Zi-Kui Liu (State College, Pennsylvania); Brandon J. Bocklund (State College, Pennsylvania); Shun-Li Shang (State College, Pennsylvania) |
| ABSTRACT | Molecular-beam epitaxy (MBE) and more particularly suboxide MBE (S-MBE) and related structures are disclosed. S-MBE is disclosed that includes the use of a molecular beam of a suboxide that may be subsequently oxidized in a single step reaction to form an oxide film. By way of example, for a gallium oxide (Ga2O3) film, a molecular beam including a suboxide of gallium (Ga2O) may be provided. S-MBE may be performed in adsorption-controlled regimes where there is an excess of source material containing species in order to promote high growth rates for oxide films with improved crystallinity. Source mixtures for providing molecular beams of suboxides are disclosed that include mixtures of a particular element and an oxide of the element in ratios that promote such adsorption-controlled growth regimes. Related structures include oxide films having increased thickness with reduced crystal defects, including single polymorph films of gallium oxide. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/076011 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/066 (20130101) C30B 29/16 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02565 (20130101) H01L 21/02631 (20130101) Original (OR) Class H01L 29/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122900 | Ellis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ELEMENT SIX TECHNOLOGIES LIMITED (Didcot, United Kingdom) |
| ASSIGNEE(S) | ELEMENT SIX TECHNOLOGIES LIMITED (Didcot, United Kingdom) |
| INVENTOR(S) | Julian Ellis (DIDCOT, United Kingdom); John Brandon (Didcot, United Kingdom); Francis Mark Reininger (PASADENA, California) |
| ABSTRACT | A synthetic diamond plate comprising a polygonal plate formed of synthetic diamond material, the polygonal plate of synthetic diamond material having a thickness in a range 0.4 mm to 1.5 mm, and rounded corners having a radius of curvature in a range 1 mm to 6 mm. A mounted synthetic diamond plate is also disclosed comprising a polygonal synthetic diamond plate as described and a base to which the polygonal synthetic diamond plate is bonded, wherein the base comprises a cooling channel. An array of mounted synthetic diamond plates is also described, comprising a plurality of mounted synthetic diamond plates described above, wherein the cooling channels of the mounted synthetic diamond plates are linked to form a common cooling channel across the array of mounted synthetic diamond plates. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/455910 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 25/18 (20130101) C30B 29/04 (20130101) C30B 29/64 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 23/3732 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123240 | Fuentes-Hernandez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Canek Fuentes-Hernandez (Atlanta, Georgia); Wen-Fang Chou (Atlanta, Georgia); Xiaojia Jia (Atlanta, Georgia); Bernard Kippelen (Atlanta, Georgia) |
| ABSTRACT | Provided is a semiconductor device having a dual gate field-effect transistor and a sensor in electrical communication with the transistor. The field-effect transistor can have a first gate electrode, a second gate electrode, a source electrode, a drain electrode, a semiconductor layer with parts in contact with the source and drain electrodes, a bi-layer gate insulator, and a second gate insulator. The bi-layer gate insulator can include a first layer and a second layer, the first layer located between the second layer and a first side of the semiconductor layer, the second layer located between the first layer and the first gate electrode. The second gate insulator can be located between the second gate electrode and a second side of the semiconductor layer, and the sensor can be in electrical communication with the second gate electrode. |
| FILED | Friday, February 07, 2020 |
| APPL NO | 17/429334 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/283 (20130101) H01L 51/0533 (20130101) H01L 51/0554 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123360 | Angell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Charles Austen Angell (Mesa, Arizona); Iolanda Santana Klein (Tempe, Arizona); Telpriore Greg Tucker (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles Austen Angell (Mesa, Arizona); Iolanda Santana Klein (Tempe, Arizona); Telpriore Greg Tucker (Phoenix, Arizona) |
| ABSTRACT | A solid electrolyte represented by general formula LiySiRx(MO4), where x is an integer from 1 to 3 inclusive, y=4−x, each R present is independently C1-C3 alkyl or C1-C3 alkoxy, and M is sulfur, selenium, or tellurium. Methods of making the solid electrolyte include combining a phenylsilane and a first acid to yield mixture including benzene and a second acid, and combining at least one of an alkali halide, and alkali amide, and an alkali alkoxide with the second acid to yield a product d represented by general formula LiySiRx(MO4)y. The second acid may be in the form of a liquid or a solid. The phenylsilane includes at least one C1-C3 alkyl substituent or at least one C1-C3 alkoxy substituent, and the first acid includes at least one of sulfuric acid, selenic acid, and telluric acid. |
| FILED | Monday, August 16, 2021 |
| APPL NO | 17/403594 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/025 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0525 (20130101) H01M 10/0564 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123516 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Qiushi Guo (Pasadena, California); Alireza Marandi (Pasadena, California) |
| ABSTRACT | A chip-scale mode-locked laser including a cavity including a gain medium for amplifying signal electromagnetic radiation (signal) through stimulated emission, the signal comprising a signal wavelength; and a passive or active mode-locking device to enforce pulse formation in the laser. The mode-locking device includes a thin-film waveguide having a thickness on the order of the signal wavelength so as to confine and guide the signal along the thin-film waveguide, and a material comprising a second-order nonlinear susceptibility to enable active or passive mode-locking of the signal. The mode-locking device leads to generation of pulses of the signal outputted from the mode-locked laser. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500425 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0632 (20130101) H01S 3/1118 (20130101) Original (OR) Class H01S 3/094026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123792 | Lanham et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | S. Andrew Lanham (Austin, Texas); Travis Cuvelier (Austin, Texas); Brian R. La Cour (Austin, Texas); Robert Heath (Raleigh, North Carolina) |
| ABSTRACT | A disclosed transmitter for wireless communication includes multiple transmitting antennas, a symbol mapper for mapping an input block including multiple binary bits and representing information to be transmitted to a symbol representing an ordered plurality of complex numbers, a space-time encoder for applying an encoding operator to the symbol to produce a vectorized space-time codeword defining electrical signals to be transmitted by the transmitter, the encoding operator being dependent on a set of predefined stabilizer generators, and circuitry to collectively transmit, by the antennas to multiple receiving antennas of a receiver over a wireless transmission channel, the electrical signals defined by the vectorized space-time codeword. The receiver includes a space-time decoder for recovering the symbol from the electrical signals transmitted by the transmitter using a decoding operation that is based on maximum likelihood inference, and a symbol de-mapper for recovering the input block from the symbol. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/565286 |
| CURRENT CPC | Transmission H04B 7/0413 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 5/0014 (20130101) Wireless Communication Networks H04W 72/046 (20130101) H04W 72/0466 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220117345 | LU |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Weiyi LU (Middleton, Wisconsin) |
| ABSTRACT | An energy absorbing apparatus includes particles with nanopores in a liquid. A further aspect employs a reusable energy absorbing apparatus including gas-liquid interactions in nanopores. Another aspect of the present apparatus uses oversolubility of gas in a solution to enhance bubble nucleation in hydrophobic nanopores or nanochannels, which suppresses gas outflow while promoting liquid outflow from particles. Still another aspect includes anions within an aqueous electrolytic solution, containing nanoporous material therein. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/498952 |
| CURRENT CPC | Hats; Head Coverings A42B 3/064 (20130101) A42B 3/121 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117894 | Nagy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Children's Hospital Los Angeles (Los Angeles, California); Nanovalent Pharmaceuticals, Inc. (Bozeman, Montana) |
| ASSIGNEE(S) | Children's Hospital Los Angeles (Los Angeles, California); Nanovalent Pharmaceuticals, Inc. (Bozeman, Montana) |
| INVENTOR(S) | Jon O. Nagy (Bozeman, Montana); Timothy J. Triche (Los Angeles, California); HyungGyoo Kang (Buena Park, California) |
| ABSTRACT | The invention relates to a novel drug delivery vehicle. Various embodiments of the invention provide a hybrid polymerized liposomal nanoparticle comprising both polymerizable lipids and non-polymerizable lipids. Therapeutic agents can be loaded into the polymerized liposomal nanoparticle and targeting agents can be conjugated to the surface of the polymerized liposomal nanoparticle. Also described in the invention are methods, compositions and kits that utilize the hybrid polymerized liposomal nanoparticle to treat disease conditions such as various cancers. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563777 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 9/1271 (20130101) A61K 9/1273 (20130101) Original (OR) Class A61K 31/136 (20130101) A61K 31/337 (20130101) A61K 31/407 (20130101) A61K 31/475 (20130101) A61K 31/573 (20130101) A61K 31/704 (20130101) A61K 31/713 (20130101) A61K 31/4745 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 45/06 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101) Y10S 977/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220117937 | Rivera et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana); University of Kansas (Lawrence, Kansas); Oklahoma State University (Stillwater, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana); University of Kansas (Lawrence, Kansas); Oklahoma State University (Stillwater, Louisiana) |
| INVENTOR(S) | Mario Rivera (Baton Rouge, Louisiana); Huili Yao (Baton Rouge, Louisiana); Richard A. Bunce (Stillwater, Oklahoma); Baskar Nammalwar (San Diego, California); Krishna Kumar Gnanasekaran (Mississauga, California); Kate Eshelman (Alexandria, Virginia); Achala N.D. Punchi Hewage (Lawrence, Kansas); Scott Lovell (Shawnee, Kansas); Anabel Soldano (Baton Rouge, Louisiana) |
| ABSTRACT | The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I: wherein R1-5 are defined herein. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502975 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4035 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118116 | Sofou et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stavroula Sofou (Baltimore, Maryland); Sarah Sally Stras (Baltimore, Maryland); Alaina Howe (Baltimore, Maryland); Aprameya Ganesh Prasad (Baltimore, Maryland); Dominick Salerno (Baltimore, Maryland) |
| ABSTRACT | Lipid-based nanocarriers (liposomes) loaded with a chemotherapeutic agent and exhibiting interstitial drug release and intratumoral adhesion are disclosed. The lipid-based nanocarriers disclosed herein include an ‘adsorptive/adhesive switch’ on the nanocarriers surface with the aim to increase the tumor residence times of the drug delivery nanocarriers and to slow down their tumor clearing kinetics. The switch is designed to promote nanoparticle adsorption on cancer cells and/or the extracellular matrix (ECM) while keeping their internalization by cells to a minimum. This approach of drug delivery is key for interstitial release of highly-diffusive forms of therapeutics. |
| FILED | Wednesday, January 29, 2020 |
| APPL NO | 17/422667 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/282 (20130101) A61K 33/243 (20190101) A61K 47/544 (20170801) A61K 51/0408 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118408 | Kumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manish Kumar (State College, Pennsylvania); Tingwei Ren (State College, Pennsylvania); Woochul Song (State College, Pennsylvania); Yu-Ming Tu (State College, Pennsylvania) |
| ABSTRACT | The present disclosure describes compositions and methods for preparing membrane protein nanosheets and two-dimensional crystals. In particular, the methods employ a solvent. A mixture of a polymer and a membrane protein is solubilized in the solvent, applied to a substrate, and subsequently dried to form the nanosheet or two-dimensional crystal. Applicants have surprisingly found that the membrane proteins maintain their structure when exposed to solvents during the short processing time utilized. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/645380 |
| CURRENT CPC | Separation B01D 67/0009 (20130101) Original (OR) Class B01D 71/24 (20130101) B01D 71/52 (20130101) B01D 71/56 (20130101) B01D 71/80 (20130101) Processes for Applying Fluent Materials to Surfaces, in General B05D 1/02 (20130101) Peptides C07K 14/31 (20130101) C07K 14/47 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118692 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF SOUTHERN CALIFORNIA (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yong Chen (Los Angeles, California); Huachao Mao (Los Angeles, California) |
| ABSTRACT | A method of multi-material 3D printing is performed by an apparatus comprising at least one printhead device; a build platform; a light source; and a computing unit comprising a non-transitory computer-readable medium encoded with program instructions for controlling the at least one printhead device; the build platform; and the light source to perform the method of multi-material 3D printing. In various embodiments, each printhead device comprises a coating section, a curing section, a cleaning section, and optionally, a post-curing section. Each printhead device is configured to perform each of these steps, with the multiple printheads engaged in fabricating a multi-material part layer-by-layer. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504169 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/35 (20170801) B29C 64/135 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/232 (20170801) B29C 64/236 (20170801) B29C 64/245 (20170801) B29C 64/255 (20170801) B29C 64/268 (20170801) B29C 64/286 (20170801) B29C 64/336 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119352 | Cai et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jianfeng Cai (Tampa, Florida); Peng Teng (Tampa, Florida); Alekhya Nimmagadda (Tampa, Florida) |
| ABSTRACT | Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516546 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4178 (20130101) A61K 38/12 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Heterocyclic Compounds C07D 233/46 (20130101) Original (OR) Class C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119445 | Raj et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Auburn University (Auburn, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Monika Raj (Atlanta, Georgia); Victor Adebomi (Atlanta, Georgia) |
| ABSTRACT | The present invention relates, in part, to novel compounds comprising 4-imidazolidinone-fused cyclic peptides and compositions thereof. The present invention also relates to methods of generating said compounds and compositions thereof as well as methods of inhibiting protein-protein interaction using said compounds or compositions thereof. In another aspect, the present invention relates, in part, to methods of treating or preventing a various diseases or disorders using said compounds or compositions thereof. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502506 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 5/123 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119462 | Garb et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts); The University of Akron (Akron, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jessica Garb (Arlington, Massachusetts); Todd A. Blackledge (Akron, Ohio); Ingi Agnarsson (South Burlington, Vermont) |
| ABSTRACT | An engineered polypeptide includes at least two units, wherein each unit includes a polypeptide of SEQ ID NO: 4, a polypeptide of SEQ ID NO: 5, a polypeptide with 90% or greater homology to SEQ ID NO: 4, or a polypeptide with 90% or greater homology to SEQ ID NO: 5, wherein the engineered polypeptide does not comprise SEQ ID NO: 12 or SEQ ID NO: 13. Further described is a synthetic materials including the peptides. Also included are synthetic materials including polypeptide of any one of SEQ ID NOs: 9-32, a polypeptide with 90% or greater homology any one of SEQ ID NOs: 9-32, a polypeptide encoded by any one of SEQ ID NOs. 57-79, or a polypeptide with 90% or greater homology to a polypeptide encoded by any one of SEQ ID NOs. 57-79. |
| FILED | Thursday, October 31, 2019 |
| APPL NO | 17/286898 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/227 (20130101) Peptides C07K 14/43518 (20130101) Original (OR) Class C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119510 | Scott et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan A. Scott (Evanston, Illinois); Guillermo A. Ameer (Evanston, Illinois); Helena Freire Haddad (Evanston, Illinois); Jacqueline A. Burke (Evanston, Illinois) |
| ABSTRACT | The present invention provides methods for generating a mouse model that produces anti-polyethylene glycol (PEG) antibodies. Also provided are mice generated by said methods and methods of using these mice to screen PEG-containing products in vivo. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/503057 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/02 (20130101) A61K 47/60 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119567 | BOWMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (DENVER, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CHRISTOPHER N. BOWMAN (BOULDER, Colorado); MATTHEW K. MCBRIDE (BOULDER, Colorado); BRADY T. WORRELL (ENGLEWOOD, Colorado); MARVIN DION ALIM (KIRKLAND, Washington); ROBERT R. MCLEOD (BOULDER, Colorado) |
| ABSTRACT | The present invention provides in one aspect holographic materials comprising a covalent adaptable networks (CAN) matrix that has exchangeable crosslinks, and at least one writing monomer, wherein upon exposure to a stimulus, the holographic material can undergo photopolymerization and serve as a recording medium. |
| FILED | Tuesday, February 18, 2020 |
| APPL NO | 17/431670 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/301 (20200201) Original (OR) Class C08F 2438/03 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 18/672 (20130101) C08G 18/3876 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/5397 (20130101) Holographic Processes or Apparatus G03H 1/02 (20130101) G03H 2001/0264 (20130101) G03H 2240/54 (20130101) G03H 2260/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119767 | Kwon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Young Jik Kwon (Irvine, California); Melissa Thone (Irvine, California); Dominique Antoinette Ingato (Irvine, California) |
| ABSTRACT | The disclosure provides methods for the production of induced cellular vesicles from natural killer cells and uses thereof, including as a cancer therapy. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 17/433573 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0646 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119812 | Mihailescu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mihaela Rita Mihailescu (Pittsburgh, Pennsylvania); Jeffrey D. Evanseck (Pittsburgh, Pennsylvania); Joshua A. Imperatore (Canonsburg, Pennsylvania); Kendy Anne Marie Guarinoni (Pittsburgh, Pennsylvania); Caylee Lyne Cunningham (East Liverpool, Ohio); Caleb James Frye (Manor, Pennsylvania); Adam Henry Kensinger (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided is an agent that binds to a SARS-CoV-2 s2m motif, a SARS-CoV-2 3′-UTR Terminus, or a SARS-CoV-2 DIS-s2m extended sequence. Provided is a method of treating an infection in a subject, comprising: administering a therapeutically effective amount of the agent to the subject. In some embodiments, the infection is SARS-CoV-2 infection. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/451521 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/141 (20130101) C12N 2310/3231 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119825 | Cornish et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Virginia Cornish (New York, New York); James Brisbois (Cambridge, Massachusetts); Sonja Billerbeck (Groningen, Netherlands); Miguel Jimenez (Winthrop, Massachusetts) |
| ABSTRACT | The present disclosure relates to intercellular signaling between genetically-engineered cells and, more specifically, to a scalable peptide-GPCR intercellular signaling system. The present disclosure provides an intercellular signaling system that includes at least two cells that have been genetically-engineered to communicate with each other, methods of use and kits thereof. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514648 |
| CURRENT CPC | Peptides C07K 14/38 (20130101) C07K 14/39 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 15/81 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119829 | Gelvin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayetter, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayetter, Indiana) |
| INVENTOR(S) | Stanton B Gelvin (West Lafayette, Indiana); Lan-Ying Lee (West Lafayette, Indiana); Rachelle Amanda Lapham (West Lafayette, Indiana) |
| ABSTRACT | The present disclosure provides transgenic plants and/or plant cells comprising overexpressed VirE2 gene or VirE2 protein in plant cytoplasm that upregulates or downregulates certain plant gene and/or proteins to facilitate transformation. The present disclosure further provides transgenic plants and/or plant cells comprising overexpressed plant gene or protein that upregulated by VirE2 gene or VirE2 protein for facilitating transformation. The transgenic plants and/or plant cells comprising downexpressed or knockout plant gene or protein that downregulated by VirE2 gene or VirE2 protein for facilitating transformation are also provided. Methods of making and using the transgenic plants and/or plants cells are also provided. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498111 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8216 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119976 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiuling Li (Austin, Texas); Apratim Khandelwal (Champaign, Illinois); Zhendong Yang (Austin, Texas) |
| ABSTRACT | An electroplating method for enhancing the performance of rolled-up passive components comprises providing an array of rolled-up passive components on a substrate, where each rolled-up passive component comprises a multilayer strip in a rolled configuration including multiple turns spaced apart by gaps. The multilayer strip comprises a conductive pattern layer on a strain-relieved layer, and a core of each rolled-up passive component is defined by a first of the multiple turns. A layer comprising a functional material is electroplated onto the conductive pattern layer of each rolled-up passive component, thereby at least partly filling the gaps and/or the core with the functional material. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/503603 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 5/10 (20130101) C25D 7/0657 (20130101) Original (OR) Class Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 17/0013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120566 | DAS |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KUTZTOWN NIVERSITY OF PENNSYLVANIA OF THE STATE SYSTEM OF PENNSYLVANIA (KUTZTOWN, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kunal DAS (Reading, Pennsylvania) |
| ABSTRACT | Embodiments relate to a sensor system configured to detect physical rotation, entire or relative, of one or more objects and/or their environment and/or proximity of a magnetic field, by measuring the degree of localization of a medium trapped in a ring-shaped artificial lattice. The lattice structure can be configured to comprise of lattice sites distributed with a lattice period around an azimuth of a closed ring. The site depths of the plurality of lattice sites can be configured to be modulated with a modulation period different from the lattice period to affect the onsite energies of each lattice site and the eigenstates of the system. Physical rotation of the sensor and/or the proximity of magnetic field will alter the localization properties so as to cause the degree of localization of the medium to change (e.g., the medium becomes more confined in space or more spread out in space). |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/645850 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/58 (20130101) Original (OR) Class Measuring Electric Variables; Measuring Magnetic Variables G01R 33/032 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120736 | Young et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Whitehead Institute for Biomedical Research (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A. Young (Boston, Massachusetts); Phillip A. Sharp (Newton, Massachusetts); Arup K. Chakraborty (Lexington, Massachusetts); Alessandra Dall'Agnese (Cambridge, Massachusetts); Krishna Shrinivas (Cambridge, Massachusetts); Brian J. Abraham (Cambridge, Massachusetts); Ann Boija (Somerville, Massachusetts); Eliot Coffey (Cambridge, Massachusetts); Daniel S. Day (Redwood City, California); Yang E. Guo (Somerville, Massachusetts); Nancy M. Hannett (Medford, Massachusetts); Tong Ihn Lee (Cambridge, Massachusetts); Charles H. Li (Waban, Massachusetts); Isaac Klein (Milton, Massachusetts); John C. Manteiga (Boston, Massachusetts); Benjamin R. Sabari (Watertown, Massachusetts); Jurian Schuijers (Somerville, Massachusetts); Abraham S. Weintraub (Cambridge, Massachusetts); Alicia V. Zamudio (Cambridge, Massachusetts); Lena K. Afeyan (Boston, Massachusetts); Ozgur Oksuz (Worcester, Massachusetts); Jonathan E. Henninger (Somerville, Massachusetts) |
| ABSTRACT | Described herein are compositions and methods for modulating gene regulation by modulating condensate formation, composition, maintenance, dissolution and regulation. |
| FILED | Friday, March 22, 2019 |
| APPL NO | 17/040967 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/535 (20130101) Original (OR) Class G01N 33/5005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120738 | Bae et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Euiwon Bae (West Lafayette, Indiana); Carmen Gondhalekar (West Lafayette, Indiana); Bartlomiej Rajwa (West Lafayette, Indiana); J. Paul Robinson (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to methods, reagents, and substrates for detecting target analytes. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/275122 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6402 (20130101) G01N 21/6428 (20130101) G01N 33/548 (20130101) G01N 33/54306 (20130101) Original (OR) Class G01N 33/54346 (20130101) G01N 2021/6439 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120921 | MORSE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown Universtiy (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Theodore F. MORSE (Providence, Rhode Island); Angus Ian KINGON (Warren, Rhode Island); Nicholas Alexander MOSTOVYCH (Silver Spring, Maryland) |
| ABSTRACT | An X-ray detector includes a scintillation plate and sensors, the scintillation plate having a glass capillary array with scintillation material filling, wherein the glass capillary array with scintillation material filling is mated with two high volume, low cost, CMOS sensors, and wherein the glass capillary array is arranged diagonally to mate with active parts of the two high volume, low cost, CMOS sensors. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/503761 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/4233 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/04 (20130101) Measurement of Nuclear or X-radiation G01T 1/20185 (20200501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121461 | YEGNESWARAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SRI International (Menlo Park, California); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinod YEGNESWARAN (Foster City, California); Ashish GEHANI (Atherton, California); Hassaan IRSHAD (Union City, California); Xutong CHEN (Evanston, Illinois); Yan CHEN (Northfield, Illinois) |
| ABSTRACT | Embodiments consistent with the present disclosure provide systems and methods for providing namespace-aware provenance tracking in a containerized environment. In some embodiments, methods for providing namespace-aware provenance tracking in a containerized environment may include monitoring, by one or more custom kernel hooks, event audit records from an OS kernel, wherein the one or more custom kernel hooks extend the functionality of the OS kernel; augmenting the event audit records from the OS kernel with one or more additional namespace aware audit records that include namespace information related to the container associated with event audit records, wherein the namespace information related to the container includes namespace IDs; processing, by an audit reporter, the namespace aware audit records to interpret the namespace IDs contained within the namespace aware audit records; and creating namespace-aware provenance graph that is namespace and container aware based on the namespace aware audit records. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/505018 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/455 (20130101) Original (OR) Class G06F 11/302 (20130101) G06F 11/3495 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121744 | MISHRA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | PRABHAT KUMAR MISHRA (GAINESVILLE, Florida); ZHIXIN PAN (GAINESVILLE, Florida); JENNIFER M. SHELDON (GAINESVILLE, Florida) |
| ABSTRACT | The present disclosure describes systems and methods for hardware-assisted malware detection. One such system comprises a memory; and a hardware processor of a computing device operatively coupled to the memory. The hardware processor is configured to execute a software application suspected of being malware; monitor behavior of the software application at run-time; and acquire an input time sequence of data records based on a trace analysis of the software application, wherein the input time sequence comprises a plurality of features of the software application. The hardware processor is further configured to classify the software application as being a malicious software application based on the plurality of features of the software application; and output a ranking of a subset plurality of features by their respective contributions towards the classification of the software application as being malicious software. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500016 |
| CURRENT CPC | Electric Digital Data Processing G06F 21/566 (20130101) G06F 21/567 (20130101) Original (OR) Class Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6284 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121855 | Farhadi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mohammad Farhadi (Tempe, Arizona); Yezhou Yang (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Mohammad Farhadi (Tempe, Arizona); Yezhou Yang (Tempe, Arizona) |
| ABSTRACT | Temporal knowledge distillation for active perception is provided. Despite significant performance improvements in object detection and classification using deep structures, they still require prohibitive runtime to process images and maintain the highest possible performance for real-time applications. Observing that a human visual system (HVS) relies heavily on temporal dependencies among frames from visual input to conduct recognition efficiently, embodiments described herein propose a novel framework dubbed as temporal knowledge distillation (TKD). The TKD framework distills temporal knowledge gained from a heavy neural network-based model over selected video frames (e.g., the perception of the moments) for a light-weight model. To enable the distillation, two novel procedures are described: 1) a long-short term memory (LSTM)-based key frame selection method; and 2) a novel teacher-bounded loss design. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504257 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00744 (20130101) Original (OR) Class G06K 9/4671 (20130101) G06K 9/6262 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0454 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122199 | Cali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EnergyXchain, LLC (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Umit Cali (Kassel Hesse, Germany); David A. Doctor (Huntersville, North Carolina); Robert W. Norris (Charlotte, North Carolina) |
| ABSTRACT | Methods and systems for improved creation, monitoring, and updating of energy transactions are provided. In one embodiment, a method is provided that includes receiving a request to originate a contract for an energy transaction. Transaction information concerning the energy transaction may be received and may identify a type of energy resource and parties for the energy transaction. A requirement for the energy transaction may be identified within the contract codex and at least one condition may be determined based on the requirement. An updated contract may be generated by adding the at least one condition to the contract. Information regarding the updated contract may be stored on the distributed ledger. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/565865 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2379 (20190101) Computer Systems Based on Specific Computational Models G06N 7/005 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 50/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122206 | Cali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EnergyXchain, LLC (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Umit Cali (Kassel Hesse, Germany); David A. Doctor (Huntersville, North Carolina); Robert W. Norris (Charlotte, North Carolina) |
| ABSTRACT | Methods and systems for originating and monitoring energy transactions using distributed ledger technology are provided. In one embodiment, a method is provided that includes receiving a first request to originate a contract associated with an energy transaction. The first request may include a first draft of the contract. A first transaction may be generated based on the first draft of the contract and may be added to a distributed ledger. Transaction information regarding the energy transaction may be received and a second draft of the contract may be generated based on the transaction information. A second transaction may be generated based on the second draft of the contract and may be added to the distributed ledger. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/565998 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/3203 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 20/389 (20130101) G06Q 40/04 (20130101) G06Q 50/06 (20130101) G06Q 50/18 (20130101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122831 | JARROLD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF INDIANA UNIVERSITY (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin F. JARROLD (Bloomington, Indiana); Daniel BOTAMANENKO (Bloomington, Indiana) |
| ABSTRACT | An electrostatic linear ion trap (ELIT) array includes a plurality of ion mirrors and a plurality of elongated charge detection cylinders each defining an axial passageway centrally therethrough, the ion mirrors and the charge detection cylinders arranged relative to one another such that each charge detection cylinder is positioned between a different respective pair of the ion mirrors with the respective axial passageways of each coaxial with one another, wherein the axial passageways of the ELITs are not coaxial with one another, means for selectively directing at least one ion into each of the plurality of ELITs, and means for controlling each of the ion mirrors in a manner which causes the at least one ion in at least two of the ELITs to become trapped therein and to simultaneously oscillate back and forth between the respective ion mirrors each time passing through the respective charge detection cylinder. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563457 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/022 (20130101) H01J 49/025 (20130101) H01J 49/0031 (20130101) H01J 49/0036 (20130101) H01J 49/406 (20130101) H01J 49/426 (20130101) H01J 49/4245 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122843 | Vogt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York); The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Vogt (Ithaca, New York); Darrell G. Schlom (Ithaca, New York); Felix V. E. Hensling (Ithaca, New York); Kathy Azizie (Plainfield, New Jersey); Zi-Kui Liu (State College, Pennsylvania); Brandon J. Bocklund (State College, Pennsylvania); Shun-Li Shang (State College, Pennsylvania) |
| ABSTRACT | Molecular-beam epitaxy (MBE) and more particularly suboxide MBE (S-MBE) and related structures are disclosed. S-MBE is disclosed that includes the use of a molecular beam of a suboxide that may be subsequently oxidized in a single step reaction to form an oxide film. By way of example, for a gallium oxide (Ga2O3) film, a molecular beam including a suboxide of gallium (Ga2O) may be provided. S-MBE may be performed in adsorption-controlled regimes where there is an excess of source material containing species in order to promote high growth rates for oxide films with improved crystallinity. Source mixtures for providing molecular beams of suboxides are disclosed that include mixtures of a particular element and an oxide of the element in ratios that promote such adsorption-controlled growth regimes. Related structures include oxide films having increased thickness with reduced crystal defects, including single polymorph films of gallium oxide. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/076011 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/066 (20130101) C30B 29/16 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02565 (20130101) H01L 21/02631 (20130101) Original (OR) Class H01L 29/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123362 | Hillmyer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Marc A. Hillmyer (Minneapolis, Minnesota); Timothy Patrick Lodge (Minneapolis, Minnesota); Lucas David McIntosh (Minneapolis, Minnesota); Morgan Whitney Schulze (St. Louis Park, Minnesota) |
| ABSTRACT | Polymer electrolyte membranes (PEMs) that include co-continuous domains of a conductive phase and a crosslinked network phase. The conductive phase can include one or more polymers having glass transition temperatures below room temperature. The crosslinked network phase can be formed from at least one monofunctional monomer and at least one di- or greater functional monomer. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563217 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 2300/0082 (20130101) H01M 2300/0085 (20130101) H01M 2300/0091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123465 | Towfiq et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | i5 Technologies, Inc. (North Logan, Utah); Utah State University (Logan, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Asaduzzaman Towfiq (North Logan, Utah); Bedri A. Cetiner (North Logan, Utah) |
| ABSTRACT | Among other things, a reconfigurable antenna array (RAA) includes individual pattern reconfigurable antennas (PRA). Each of the PRAs has (a) an antenna, (b) components controllable to generate and effect any of two or more modes of the PRA, the modes having respectively different steered radiation patterns, and (c) inputs to receive drive signals for the antenna and control signals for the controllable components. Control circuitry has outputs coupled to the inputs of the PRAs to drive the antennas of the PRAs to form an array beam having an array peak in a particular direction and at the same time to deliver control signals for the controllable components to effect a selected mode of each of the PRAs for which the steered radiation pattern has a peak in the particular direction of the array beam and has one or more nulls in the directions of one or more of the side-lobes of the array beam. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/566145 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 3/2617 (20130101) Original (OR) Class H01Q 9/0442 (20130101) H01Q 19/005 (20130101) H01Q 21/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123516 | Guo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Qiushi Guo (Pasadena, California); Alireza Marandi (Pasadena, California) |
| ABSTRACT | A chip-scale mode-locked laser including a cavity including a gain medium for amplifying signal electromagnetic radiation (signal) through stimulated emission, the signal comprising a signal wavelength; and a passive or active mode-locking device to enforce pulse formation in the laser. The mode-locking device includes a thin-film waveguide having a thickness on the order of the signal wavelength so as to confine and guide the signal along the thin-film waveguide, and a material comprising a second-order nonlinear susceptibility to enable active or passive mode-locking of the signal. The mode-locking device leads to generation of pulses of the signal outputted from the mode-locked laser. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500425 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/0632 (20130101) H01S 3/1118 (20130101) Original (OR) Class H01S 3/094026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123594 | Joannopoulos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Joannopoulos (Belmont, Massachusetts); Aristeidis Karalis (Boston, Massachusetts); Marin Soljacic (Belmont, Massachusetts) |
| ABSTRACT | Described herein are embodiments of a source high-Q resonator, optionally coupled to an energy source, a second high-Q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. A third high-Q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. The source resonator and at least one of the second resonator and third resonator may be coupled to transfer electromagnetic energy from said source resonator to said at least one of the second resonator and third resonator. |
| FILED | Tuesday, August 31, 2021 |
| APPL NO | 17/462126 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 53/126 (20190201) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 38/14 (20130101) Antennas, i.e Radio Aerials H01Q 9/04 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/12 (20160201) Original (OR) Class Climate Change Mitigation Technologies Related to Transportation Y02T 10/70 (20130101) Y02T 10/7072 (20130101) Y02T 90/12 (20130101) Y02T 90/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123976 | Mangal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vivek Mangal (Santa Clara, California); Peter R. Kinget (Summit, New Jersey) |
| ABSTRACT | Circuit for wake-up receivers are provide. In some embodiments, the wake-up receivers include self-mixers that receive a gate bias voltage. Some of the self-mixers are single ended and some are differential. In some embodiments, the wake-up receivers include a matching network that is connected to the input of the self-mixer. In some embodiments, the wake-up receivers include a low frequency path connected to the output of the self-mixer. In some embodiments, the wake-up receivers include a high frequency path connected to the output of the self-mixer. In some embodiments, the wake-up receivers are configured to receive an encoded bit stream. In some embodiments, the wake-up receivers are configured to wake-up another receiver. |
| FILED | Monday, January 06, 2020 |
| APPL NO | 17/419138 |
| CURRENT CPC | Pulse Technique H03K 19/0185 (20130101) H03K 19/17788 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/06 (20130101) Original (OR) Class H04L 27/2617 (20130101) H04L 27/26412 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220124273 | Bobda et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christophe Bobda (Gainesville, Florida); Pankaj Bhowmik (Gainesville, Florida); Md Jubaer Hossain Pantho (Gainesville, Florida) |
| ABSTRACT | Methods and systems are directed to enabling CNN operation close to an image sensor and facilitating CNN inference near the image sensor. The system includes, in part, a digital image sensor and a plurality of processing layers that include, in part, an attention-based preprocessing layer (APL), an inference computation layer (ICL), and a fully connected layer. The digital image sensor can include, in part, a plurality of regions and each region can be processed by region processing units disposed in the APL/ICL in parallel. Each region processing unit disposed in the APL can include, in part, an attention module that determines whether the corresponding region is a relevant region. The region processing units disposed in the APL transmit only relevant data to corresponding region processing units in the ICL and only activate the corresponding region processing units in the ICL for relevant regions. The ICL can include, in part, two convolution layers. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495420 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 5/04 (20130101) Pictorial Communication, e.g Television H04N 5/379 (20180801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220124505 | Lin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhiqiang Lin (Columbus, Ohio); Yue Zhang (Columbus, Ohio) |
| ABSTRACT | Bluetooth Address Tracking (BAT) is an allowlist-based side channel attack to track Bluetooth devices, by either passively sniffing the Bluetooth packets, or actively replaying the sniffed ones. Securing addresses of Bluetooth Low Energy (BLE) is described, which uses an interval unpredictable, central and peripheral synchronized random media access control (MAC) address generation scheme to defend against passive BAT attacks, and uses a current timestamp to derive random MAC addresses to defeat active BAT attacks, such that attackers can no longer be able to replay them. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506011 |
| CURRENT CPC | Wireless Communication Networks H04W 4/80 (20180201) H04W 12/122 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220118424 | Knipe et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jennifer Marie Knipe (Oakland, California); Sarah E. Baker (Dublin, California); Maira Ceron Hernandez (Brentwood, California); Jeremy M. Lenhardt (Tracy, California); Simon Hoching Pang (Fremont, California); Joshuah K. Stolaroff (Oakland, California); Matthew A. Worthington (Oakland, California) |
| ABSTRACT | An ink includes a vinyl-terminated polydimethylsiloxane polymer, a polydimethylsiloxane copolymer having a hydride component, wherein a hydride to a vinyl ratio (hydride:vinyl) is in a range of greater than 1:1 to about 4:1, a hydrophobic filler, a crosslinking agent, and a carbon dioxide-binding component. A method includes extruding an ink for forming a three-dimensional (3D) structure, the ink including a vinyl-terminated polydimethylsiloxane polymer, a polydimethylsiloxane copolymer having a hydride component, wherein a hydride to a vinyl ratio (hydride:vinyl) is in a range of greater than 1:1 to about 4:1, a hydrophobic filler, a crosslinking agent, and a carbon dioxide-binding component. The method further includes curing the 3D structure for forming a silicone polymer product having the carbon dioxide-binding component. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504336 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/267 (20130101) Original (OR) Class B01J 20/28042 (20130101) B01J 2220/46 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2083/00 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/00 (20141201) Compositions of Macromolecular Compounds C08L 83/04 (20130101) C08L 2205/02 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 7/61 (20180101) C09D 7/69 (20180101) C09D 183/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118501 | Ren et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Huaqing Ren (Santa Clara, California); Jiaxi Xie (Evanston, Illinois); Shuheng Liao (Evanston, Illinois); Dohyun Leem (Evanston, Illinois); Jian Cao (Wilmette, Illinois); Kornel F. Ehmann (Evanston, Illinois) |
| ABSTRACT | Novel systems and methods for an incremental forming process to manufacture a product are disclosed herein. The system and method generally involves continuously modifying the toolpath in real-time based upon the forming force of the forming tool compared to a predicted springback error established offline from a series of simplified simulations. The system and method disclosed herein are effective to form products with complex geometries and minimizes the costs and time requirements associated with prior art techniques. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/430452 |
| CURRENT CPC | Working or Processing of Sheet Metal or Metal Tubes, Rods or Profiles Without Essentially Removing Material; Punching Metal B21D 31/005 (20130101) Original (OR) Class Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/404 (20130101) G05B 2219/45234 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220118980 | Gupta et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cummins Inc. (Columbus, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rohinish Gupta (Columbus, Indiana); Jonathan A. Dickson (Columbus, Indiana); Kenneth M. Follen (Greenwood, Indiana); Apurva Arvind Chunodkar (Greenwood, Indiana); Arun Prakash Thunga Gopal (Columbus, Indiana); Manik Narula (Columbus, Indiana) |
| ABSTRACT | The enclosed disclosure relates to hybrid vehicles and systems with an engine, a drivetrain with a clutch and a transmission, an electric machine, and a controller. The controller receives lookahead information within a lookahead window and present state information of the hybrid vehicle. The controller determines a predicted coasting opportunity exceeding a predetermined threshold within the lookahead window and determines a cruise control reference speed, a power split between the engine and the electric machine, and a timing of enabling engine-off coasting during the coasting opportunity. The controller deactivates the engine and disengages the clutch at a start of the coasting opportunity when the engine-off coasting is enabled. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/075826 |
| CURRENT CPC | Conjoint Control of Vehicle Sub-units of Different Type or Different Function; Control Systems Specially Adapted for Hybrid Vehicles; Road Vehicle Drive Control Systems for Purposes Not Related to the Control of a Particular Sub-unit B60W 10/08 (20130101) B60W 20/12 (20160101) B60W 20/15 (20160101) B60W 30/18127 (20130101) Original (OR) Class B60W 40/06 (20130101) B60W 40/105 (20130101) B60W 2510/0208 (20130101) B60W 2510/244 (20130101) B60W 2556/45 (20200201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119657 | Lenhardt |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy M. Lenhardt (Tracy, California) |
| ABSTRACT | An ink includes a siloxane polymer having at least 13 mol. % diphenylsiloxane content relative to the total mol. % of the siloxane polymer, and a filler having a refractive index about matching a refractive index of the siloxane polymer where the refractive indices are within about 5% of one another but are ideally as closely matched as possible. |
| FILED | Tuesday, October 20, 2020 |
| APPL NO | 17/075549 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/129 (20170801) Indexing Scheme Associated With Subclasses B29B, B29C or B29D, Relating to Moulding Materials or to Materials for Reinforcements, Fillers or Preformed Parts, e.g Inserts B29K 2083/00 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 77/04 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/36 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/102 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119709 | Shanks et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brent Shanks (Ames, Iowa); George A. Kraus (Ames, Iowa); William Bradley (Schaumburg, Illinois); Jiajie Huo (Boulder, Colorado); Kyle Podolak (Ames, Iowa) |
| ABSTRACT | A heteroaryl-thio-substituted pyrone compound that is a heteroaryl-thio-substituted pyrone or a heteroaryl-thio-substituted coumarin. In various embodiments, the heteroaryl-thio-substituted pyrone compound or a reaction product thereof is a metal corrosion inhibitor. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/504307 |
| CURRENT CPC | Heterocyclic Compounds C07D 213/70 (20130101) C07D 233/84 (20130101) C07D 235/28 (20130101) C07D 249/12 (20130101) C07D 277/36 (20130101) C07D 285/125 (20130101) C07D 405/12 (20130101) C07D 409/12 (20130101) C07D 417/12 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 5/086 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 15/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119783 | Dietrich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lygos, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey A. Dietrich (Berkeley, California); Jeffrey L. Fortman (Berkeley, California); Eric J. Steen (Berkeley, California) |
| ABSTRACT | Systems and methods for the production of malonate in recombinant host cells. |
| FILED | Wednesday, December 29, 2021 |
| APPL NO | 17/646437 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 67/31 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/46 (20130101) Enzymes C12Y 301/02004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119810 | Peters et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Peters (Madison, Wisconsin); Amy Banta (Madison, Wisconsin) |
| ABSTRACT | Described herein are synthetic inducible promoters including 5′-(UP element)-(−35 element)-(spacer element)-(−10 element)-(discriminator element)-3′. Also included are vectors, α-Proteobacteria strains and γ-Proteobacteria strains including the synthetic inducible promoters. A Mobile-CRISPRi plasmid and methods of partially or fully knocking-down expression of a gene in α-Proteobacteria or γ-Proteobacteria are also described. Further included are methods of making an α-Proteobacteria or γ-Proteobacteria strain. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501421 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/111 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2800/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119821 | Dietrich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lygos, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey A. Dietrich (Berkeley, California); Mario Ouellet (Berkeley, California); Ee-Been Goh (Berkeley, California); Chi Le (Berkeley, California); Kelvin Shing (Berkeley, California); Drew Ross (Berkeley, California); Daniel Blackburn (Berkeley, California) |
| ABSTRACT | Methods and materials related to producing aspartic acid, β-alanine and salts of each thereof are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, methods and materials for producing aspartic acid by direct fermentation from sugars are disclosed. |
| FILED | Monday, June 24, 2019 |
| APPL NO | 16/973270 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/02 (20130101) C12N 1/20 (20130101) C12N 9/001 (20130101) C12N 9/0016 (20130101) C12N 9/88 (20130101) C12N 9/93 (20130101) C12N 9/1096 (20130101) C12N 15/52 (20130101) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/06 (20130101) C12P 13/20 (20130101) Enzymes C12Y 103/05001 (20130101) C12Y 104/01021 (20130101) C12Y 206/01001 (20130101) C12Y 401/01011 (20130101) C12Y 401/01031 (20130101) C12Y 401/01049 (20130101) C12Y 604/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119849 | JOHNSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher W. JOHNSON (Denver, Colorado); Allison Jean ZIMONT WERNER (Denver, Colorado); Gregg Tyler BECKHAM (Golden, Colorado); Sandra Fabienne NOTONIER (Marseille, France) |
| ABSTRACT | The present disclosure relates to a genetically modified microbial cell that includes a first genetic modification resulting in the expression of an exogenous vanillate demethylase, such that the microbial cell is capable of metabolizing an S-lignin decomposition product and producing 2-pyrone-4,6-dicarboxylate (PDC). |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/504901 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) C12N 9/0071 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/44 (20130101) Original (OR) Class Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/39 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119965 | Yang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peidong Yang (Kensington, California); Dohyung Kim (Sunnyvale, California); Sunmoon Yu (Albany, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to nanoparticle/ordered-ligand interlayers. In one aspect, a structure comprises an assembly and a layer of ligands disposed on a surface of the assembly. The assembly comprises a plurality of metal nanoparticles. The metal nanoparticles of the plurality of metal nanoparticles in the assembly are proximate one another. The layer of ligands is operable to detach from the surface of the assembly but to remain proximate the surface of the assembly when the assembly is disposed in an electrolyte and a negative bias is applied to the assembly. An interlayer forms between the assembly and the layer of ligands, with the interlayer comprising desolvated cations from the electrolyte. |
| FILED | Monday, October 11, 2021 |
| APPL NO | 17/498260 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) C25B 3/03 (20210101) C25B 3/07 (20210101) C25B 11/037 (20210101) C25B 11/042 (20210101) Original (OR) Class C25B 11/052 (20210101) C25B 11/061 (20210101) C25B 11/065 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120515 | Borghese et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Borghese (Yucca Valley, California); Quang Do (La Palma, California); David Berukhim (Los Angeles, California); Rafael Maldonado (Redondo Beach, California) |
| ABSTRACT | A heat exchanger includes a shell housing a plurality of tubes and defining an exhaust fluid flow path within a first volume enclosed by the shell. The outer surfaces of the plurality of tubes are in fluid communication with the exhaust fluid flow path. The heat exchanger includes a cap attached to a first end of the shell and defining a second volume. A header is configured to separate the first volume from the second volume, flex with thermal expansion, and define tube inlet and outlet positions. The tube inlets and outlets are in fluid communication with a source fluid flow path, and each tube is substantially U-shaped and defines a flow path of the source fluid within the exhaust fluid flow path. The heat exchanger includes at least one longitudinal flow baffle within the shell configured to reduce an amount of exhaust fluid that may bypass the tubes. |
| FILED | Monday, January 18, 2021 |
| APPL NO | 17/151534 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/10 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 7/06 (20130101) F28D 7/0083 (20130101) F28D 7/1607 (20130101) F28D 21/001 (20130101) Original (OR) Class Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 9/0243 (20130101) F28F 2225/08 (20130101) F28F 2265/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120538 | Wilkins |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul R. Wilkins (Oakland, California) |
| ABSTRACT | An opto-thermal laser detonator uses resonantly absorptive tuned nano-material associated with secondary explosives for optical absorption and initiation by an integral laser diode. The opto-thermal laser detonator includes main explosive material; resonantly absorptive tuned nano-material; secondary explosive material, wherein the resonantly absorptive tuned nano-material and the secondary explosive material are associated to form associated material made of the resonantly absorptive tuned nano-material and the secondary explosive material; and a laser diode operatively connected to the associated material, wherein the laser diode initiates the associated material which in turn initiates |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/460717 |
| CURRENT CPC | Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 3/11 (20130101) F42B 3/113 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120784 | TESSMER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Stuart Holden TESSMER (Okemos, Michigan); Eric William GOODWIN (Dewitt, Michigan); Oleksandr LEVCHENKO (Middleton, Wisconsin) |
| ABSTRACT | A quantum dot microscope apparatus is provided. A further aspect employs a tilted or tapered end or tip on a microscopic probe. Another aspect of the present apparatus employs a probe including a quantum dot with only one tunneling lead connected to a power source. A manufacturing aspect includes creating a tapered or asymmetrically shaped specimen-facing end of a probe where a quantum dot is located on the end. A further manufacturing aspect includes using focused ion-beam milling to create a tip or end of a quantum dot microscope probe. |
| FILED | Tuesday, October 05, 2021 |
| APPL NO | 17/493998 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6458 (20130101) G01N 33/588 (20130101) Scanning-probe Techniques or Apparatus; Applications of Scanning-probe Techniques, e.g Scanning Probe Microscopy [SPM] G01Q 60/16 (20130101) G01Q 60/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120920 | Jarrell et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joshua Jarrell (Livermore, California); Nerine Cherepy (Piedmont, California); John Winter Murphy (Mountain House, California); Rebecca J. Nikolic (Oakland, California); Erik Lars Swanberg, JR. (Livermore, California) |
| ABSTRACT | A product includes a transparent scintillator material, a beta emitter material having an end-point energy of greater than 225 kiloelectron volts (keV), and a photovoltaic portion configured to convert light emitted by the scintillator material to electricity. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/073015 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 1/2002 (20130101) G01T 1/2023 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/115 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120924 | Chuirazzi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Steven L. Cool (Reading, Massachusetts); Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William C. Chuirazzi (Idaho Falls, Idaho); Aaron Craft (Idaho Falls, Idaho); Steven L. Cool (Reading, Massachusetts); Burkhard Schillinger (Munchen, Delaware) |
| ABSTRACT | A fast neutron scintillator screen includes a converter material and a scintillator material in contact with the converter material. The converter material comprises a hydrogenous material, exhibits a thickness of from about 10 μm to about 1500 μm, and is formulated to produce recoil protons responsive to interactions with neutrons. The scintillator material comprises a phosphor formulated to produce photons responsive to interactions with the recoil protons. A method of conducting neutron radiography is also disclosed, as well as a system comprising the fast neutron scintillator screen. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/451610 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 3/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121085 | Muir et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan D. Muir (Livermore, California); Vincent J. Hernandez (Brisbane, California); Brandon W. Buckley (Walnut Creek, California); Daniel E. Mittelberger (Livermore, California); John E. Heebner (San Ramon, California) |
| ABSTRACT | The nonlinearities of cascaded and series configurations of Mach-Zehnder electrooptic modulators are utilized to increase signal bandwidth and boost signal fidelity in electronic digital to analog converters. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/075953 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/2255 (20130101) G02F 1/2257 (20130101) G02F 7/00 (20130101) Original (OR) Class G02F 2001/212 (20130101) Transmission H04B 10/556 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121429 | Haile et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE ENERGY ALLIANCE, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | BATTELLE ENERGY ALLIANCE, LLC (Idaho Falls, Idaho) |
| INVENTOR(S) | Jedediah T. Haile (Idaho Falls, Idaho); Bryan R. Beckman (Idaho Falls, Idaho); Sage R. Havens (Idaho Falls, Idaho); Jared A. Verba (Idaho Falls, Idaho); Garrett W. Larsen (Idaho Falls, Idaho); May R. Chaffin (Idaho Falls, None); Rita A. Foster (Idaho Falls, Idaho) |
| ABSTRACT | Binaries configured for execution within respective computing environments may be disassembled into architecture-specific intermediate (AIL) representations. The AIL representations may be converted into canonical intermediate language (CIL) representations. The CIL representations may comprise normalized, architecture-independent code configured to characterize functionality of respective components of a binary (e.g., respective functions or the like). Feature vectors may be extracted from the CIL representations. The feature vectors may be used to identify components of respective binaries, assign security classifications to the binaries, and/or the like. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/505613 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/43 (20130101) G06F 8/44 (20130101) Original (OR) Class G06F 8/52 (20130101) G06F 8/427 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122300 | Jimenez, JR. et al. |
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| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Steven Jimenez, JR. (Albuquerque, New Mexico); Srivathsan Prabu Koundinyan (Bordentown, New Jersey); Isabel Gallegos (Albuquerque, New Mexico); Adriana Stohn (Chandler, Arizona); Gabriella Dalton (Albuquerque, New Mexico) |
| ABSTRACT | A calibration method for an x-ray computerized tomography system and a method of tomographic reconstruction are provided. The calibration method includes steps of measuring at least one point spread function (PSF) at each of a plurality of points, compressing each PSF, and in one or more storing operations, storing the compressed PSFs in a computer-accessible storage medium. The PSF measurements are made in a grid of calibration points in a field of view (FOV) of the system. In the measuring step, an absorber is positioned at each of the calibration points, and an x-ray projection is taken at least once at each of those absorber positions. In the method of tomographic image reconstruction, projection data from an x-ray tomographic projection system are input to an iterative image reconstruction algorithm. The algorithm retrieves and utilizes a priori system information (APSI) The APSI comprises comprising point spread functions (PSFs) of all voxels in a voxelization of the field of view that are compressed in the form of vectors of parameters. For utilization, each retrieved vector of parameters is decompressed so as to generate a discretized PSF. |
| FILED | Thursday, December 16, 2021 |
| APPL NO | 17/553221 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/032 (20130101) A61B 6/586 (20130101) A61B 6/4085 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/046 (20130101) Image Data Processing or Generation, in General G06T 11/005 (20130101) Original (OR) Class G06T 11/006 (20130101) G06T 2207/10081 (20130101) G06T 2211/424 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123158 | OH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jihun OH (Golden, Colorado); Howard M. BRANZ (Golden, Colorado); Hao-Chih YUAN (Conifer, Colorado) |
| ABSTRACT | A photovoltaic (PV) device with improved blue response. The PV device includes a silicon substrate with an emitter layer on a light receiving side. The emitter layer has a low dopant level such that it has sheet resistance of 90 to 170 ohm/sq. Anti-reflection in the PV device is provided solely by a nano-structured or black silicon surface on the light-receiving surface, through which the emitter is fanned by diffusion. The nanostructures of the black silicon are formed in a manner that does not result in gold or another high-recombina-tion metal being left in the black silicon such as with metal-assisted etching using silver. The black silicon is further processed to widen these pores so as to provide larger nanostruc-tures with lateral dimensions in the range of 65 to 150 nanometers so as to reduce surface area and also to etch away a highly doped portion of the emitter. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/561361 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 31/0284 (20130101) H01L 31/1868 (20130101) H01L 31/02168 (20130101) Original (OR) Class H01L 31/02363 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 10/50 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 70/50 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123211 | Voss et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lars F. Voss (Livermore, California); Adam Conway (Livermore, California); Karen Marie Dowling (Dublin, California); David Lawrence Hall (San Ramon, California); Shaloo Rakheja (Urbana Champaign, Illinois); Kexin Li (Urbana, Illinois) |
| ABSTRACT | A photoconductive switch that uses materials that support negative differential mobility, whose operation leverages the pulse compression of a charge could to generate the “on” time of the pulse in combination with the speed of light to generate the “off” time of the pulse, is described. In one example, a method of operating a photoconductive switch, which includes two electrodes and a light absorbing material positioned therebetween, includes selecting a value for one or more parameters comprising a voltage for generation of an electric field, a spot size of a laser pulse, a temporal pulse width of the laser pulse, or an intensity of the laser pulse, wherein the selected value(s) for the one or more parameters enable the switch to operate in a region where the light absorbing material exhibits negative differential mobility, and illuminating the light absorbing material with the laser pulse to generate a charge cloud within the light absorbing material. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502681 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 47/023 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123240 | Fuentes-Hernandez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Canek Fuentes-Hernandez (Atlanta, Georgia); Wen-Fang Chou (Atlanta, Georgia); Xiaojia Jia (Atlanta, Georgia); Bernard Kippelen (Atlanta, Georgia) |
| ABSTRACT | Provided is a semiconductor device having a dual gate field-effect transistor and a sensor in electrical communication with the transistor. The field-effect transistor can have a first gate electrode, a second gate electrode, a source electrode, a drain electrode, a semiconductor layer with parts in contact with the source and drain electrodes, a bi-layer gate insulator, and a second gate insulator. The bi-layer gate insulator can include a first layer and a second layer, the first layer located between the second layer and a first side of the semiconductor layer, the second layer located between the first layer and the first gate electrode. The second gate insulator can be located between the second gate electrode and a second side of the semiconductor layer, and the sensor can be in electrical communication with the second gate electrode. |
| FILED | Friday, February 07, 2020 |
| APPL NO | 17/429334 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/283 (20130101) H01L 51/0533 (20130101) H01L 51/0554 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123293 | Takeuchi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brookhaven Science Associates, LLC (Upton, New York); The Research Foundation For The State University of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Esther Sans Takeuchi (South Setauket, New York); Altug S. Poyraz (Port Jefferson, New York); Kenneth James Takeuchi (South Setauket, New York); Amy Catherine Marschilok (Stony Brook, New York) |
| ABSTRACT | A binder-free, self-supporting electrode including an electrochemically active material in the absence of a binder and a current collector is claimed. The electrochemically active material is a self-supporting transition metal oxide. A method of regenerating the electrode to restore capacity of the electrode is also claimed. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511522 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 45/1228 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/48 (20130101) H01M 4/131 (20130101) H01M 4/505 (20130101) Original (OR) Class H01M 4/624 (20130101) H01M 4/625 (20130101) H01M 10/052 (20130101) H01M 10/54 (20130101) H01M 2220/30 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 10/70 (20130101) Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management Y02W 30/84 (20150501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123312 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Matthew Li (Chicago, Illinois); Khalil Amine (Oakbrook, Illinois); Jun Lu (Naperville, Illinois) |
| ABSTRACT | An electrochemical device includes a cathode comprising a first cathode component of lithium and SexSy; and a second cathode component of an alkali metal and/or alkaline earth metal sulfur and/or selenide, different from the first cathode component; an initial discharge product of a polyselenide and/or polysulfide anion charge compensated by an alkali metal and/or alkaline earth metal cation; an anode; a porous separator; and a non-aqueous electrolyte with one or more lithium salts, and one or more solvents; wherein the electrochemical device is a lithium sulfur and/or lithium selenide battery. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/477828 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/5815 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 10/0569 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123344 | Song et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ESS Tech, Inc. (Wilsonville, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Song (West Linn, Oregon); Kenneth Kiyoshi Fisher (Portland, Oregon); Timothy McDonald (Portland, Oregon) |
| ABSTRACT | A multi-chambered electrolyte storage tank for a redox flow battery system, may include first and second electrolyte chambers, and a bulkhead, wherein the first and second electrolyte chambers are fluidly coupled to first and second sides of a redox flow battery cell, respectively, the first and second electrolyte chambers include first and second liquid electrolyte volumes, respectively, and the first and second liquid electrolyte volumes are separated by the bulkhead positioned therebetween. In this way, manufacturing and operational complexity of a redox flow battery system can be reduced. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/456948 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/188 (20130101) Original (OR) Class H01M 8/0202 (20130101) H01M 8/0289 (20130101) H01M 8/2455 (20130101) H01M 8/2484 (20160201) H01M 8/04037 (20130101) H01M 8/04097 (20130101) H01M 8/04201 (20130101) Reduction of Greenhouse Gas [GHG] Emissions, Related to Energy Generation, Transmission or Distribution Y02E 60/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123359 | PLATT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SOLID POWER, INC. (LOUISVILLE, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | HEATHER A.S. PLATT (GOLDEN, Colorado); BRIAN E. FRANCISCO (ARVADA, Colorado); BENJAMIN A. CARLSON (MINNEAPOLIS, Minnesota); JOSHUA BUETTNER-GARRETT (ARVADA, Colorado) |
| ABSTRACT | A solid electrolyte material may be advantageously synthesized using a multipart solvent/solution based method employing selective solvation and/or particle size reduction for different reactants used to form the solid electrolyte. |
| FILED | Friday, January 25, 2019 |
| APPL NO | 17/425230 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220123437 — Biodegradable Transient Battery Built on Core-Double-Shell Zinc Microparticle Networks
| US 20220123437 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisonsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xudong Wang (Middleton, Wisconsin); Yutao Dong (Madison, Wisconsin) |
| ABSTRACT | A transient or biodegradable battery is provided having a filament structure that limits the speed of reaction allowing for a longer duration of battery power with a controlled current limit. In one embodiment, the filament may be constructed of zinc microparticles or nanoparticles having a thin outer insulation whereby a chemical reaction at the center core results in the progressive disintegration of the insulation revealing more core material. In one embodiment, microparticles or nanoparticles are coated with outer layers of chitosan and Al2O3 nanofilms, respectively, with designable discharge current and battery lifespan by controlling the exposed cross-sectional area of the zinc microparticle center core and the length of the filament, respectively. This novel structure of biodegradable battery provides improved control of battery life and power output, providing a promising solution to power transient medical implants. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501490 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/622 (20130101) H01M 6/02 (20130101) H01M 6/34 (20130101) H01M 50/107 (20210101) H01M 50/469 (20210101) Original (OR) Class H01M 2004/022 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220119133 | LO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin W. LO (Pasadena, California); Brian D. ANDERSON (Pasadena, California); Ryan BURNS (Pasadena, California); Damon LANDAU (Pasadena, California); Jared T. BLANCHARD (Stanford, California) |
| ABSTRACT | Systems and methods are described for computing a trajectory of an object in space to a secondary body (M2) in orbit around a primary body to land on, or capture into orbit, or flyby M2 in a Three-Or-More Body Problem. A special plotting of sampled vectors from M2 are integrated backward using a Poincaré Map to form a “Swiss Cheese plot” to find a nominal trajectory. A funnel-like set of trajectories can be constructed along the nominal trajectory for navigation purposes. A global resonant encounter map over a sphere around M2 can be constructed to provide trajectories to, for example, flyby any point near M2, capture into orbit over any point about M2, land on any point on M2. Besides space exploration, there are many applications to the development of Cislunar space commercialization and colonization including asteroid capture and mining. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506436 |
| CURRENT CPC | Cosmonautics; Vehicles or Equipment Therefor B64G 1/007 (20130101) B64G 1/66 (20130101) B64G 1/242 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120653 | Brosius et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida); United States of America as Represented by The Administrator of NASA (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nevin B. Brosius (Gainesville, Florida); Ranganathan Narayanan (Gainesville, Florida); Michael P. SanSoucie (Huntsville, Alabama) |
| ABSTRACT | Various examples are provided related to measuring surface tension. In one example, a method includes levitating a sample using electrostatic levitation; applying a signal to at least one electrode to excite the sample into a n=3 mode of oscillation; capturing images of the sample with a respective image being associated with a particular frequency that is applied to the sample when the respective image is captured; quantifying sample resonance using a projection method of Legendre polynomials based on the plurality of images; and determining a measured resonance frequency of the sample by an analysis of the sample resonance. The sample can be levitated using a feedback-controlled voltage and the applied signal can be swept over a range of frequencies. A system including electrodes, a position sensor, a camera device, and at least one computing device can be used to carry out the method. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/505224 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 13/02 (20130101) Original (OR) Class G01N 2013/0225 (20130101) G01N 2013/0283 (20130101) Image Data Processing or Generation, in General G06T 7/62 (20170101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121786 | Murphy et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick C. Murphy (Suffolk, Virginia); PIETER G. BUNING (Yorktown, Virginia) |
| ABSTRACT | A Rapid Aero Modeling program and process may be applied to computational experiments such as computational fluid dynamics (CFD) programs to obtain aerodynamic models which may be in the form of polynomial equations. The program and process may be utilized to estimate (develop) aerodynamic models appropriate for flight dynamics studies, simulations, and the like. Feedback loops are provided around computational codes to rapidly guide testing toward aerodynamic models that meet user-defined fidelity criteria. A user has the freedom to choose a specific level of fidelity in terms of prediction error, in advance of a CFD test (computation). |
| FILED | Friday, January 08, 2021 |
| APPL NO | 17/144995 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/15 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220122843 | Vogt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York); The Penn State Research Foundation (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick Vogt (Ithaca, New York); Darrell G. Schlom (Ithaca, New York); Felix V. E. Hensling (Ithaca, New York); Kathy Azizie (Plainfield, New Jersey); Zi-Kui Liu (State College, Pennsylvania); Brandon J. Bocklund (State College, Pennsylvania); Shun-Li Shang (State College, Pennsylvania) |
| ABSTRACT | Molecular-beam epitaxy (MBE) and more particularly suboxide MBE (S-MBE) and related structures are disclosed. S-MBE is disclosed that includes the use of a molecular beam of a suboxide that may be subsequently oxidized in a single step reaction to form an oxide film. By way of example, for a gallium oxide (Ga2O3) film, a molecular beam including a suboxide of gallium (Ga2O) may be provided. S-MBE may be performed in adsorption-controlled regimes where there is an excess of source material containing species in order to promote high growth rates for oxide films with improved crystallinity. Source mixtures for providing molecular beams of suboxides are disclosed that include mixtures of a particular element and an oxide of the element in ratios that promote such adsorption-controlled growth regimes. Related structures include oxide films having increased thickness with reduced crystal defects, including single polymorph films of gallium oxide. |
| FILED | Wednesday, October 21, 2020 |
| APPL NO | 17/076011 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/066 (20130101) C30B 29/16 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/02565 (20130101) H01L 21/02631 (20130101) Original (OR) Class H01L 29/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220119832 | HUNTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia); AUM LifeTech, Inc. (PHILADELPHIA, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | WAYNE B. HUNTER (PORT ST LUCIE, Florida); VEENU AISHWARYA (PHILADELPHIA, Pennsylvania) |
| ABSTRACT | Herein is disclosed synthetic oligonucleotides comprising 2′F-ANA nucleosides that can be utilized to control plant-chewing and phloem-feeding insects, bacteria present in such insects, and bacteria present in plants. The novel approaches and materials provided herein allow for reduction of pesticide and antibiotic use without the need to create genetically modified plants. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/568884 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 15/8218 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/323 (20130101) C12N 2310/346 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220119856 | SILVER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRANSFORMATIVE TECHNOLOGIES (Baltimore, Maryland) |
| ASSIGNEE(S) | TRANSFORMATIVE TECHNOLOGIES (Baltimore, Maryland) |
| INVENTOR(S) | Lawrence SILVER (Westbury, New York); Lawrence LOOMIS (Columbia, Maryland); David DONOVAN (Baltimore, Maryland) |
| ABSTRACT | The present invention relates to several methods to detect gram positive mastitis pathogens in a small sample of bovine milk by luminescence using a combination of specific reagents giving a “cow side” “in-stall” indication of the presence or absence of gram positive mastitis pathogens within a short period of time. |
| FILED | Thursday, January 30, 2020 |
| APPL NO | 17/427587 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/06 (20130101) C12Q 1/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220120738 | Bae et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Euiwon Bae (West Lafayette, Indiana); Carmen Gondhalekar (West Lafayette, Indiana); Bartlomiej Rajwa (West Lafayette, Indiana); J. Paul Robinson (West Lafayette, Indiana) |
| ABSTRACT | The invention generally relates to methods, reagents, and substrates for detecting target analytes. |
| FILED | Friday, September 13, 2019 |
| APPL NO | 17/275122 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6402 (20130101) G01N 21/6428 (20130101) G01N 33/548 (20130101) G01N 33/54306 (20130101) Original (OR) Class G01N 33/54346 (20130101) G01N 2021/6439 (20130101) G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220120645 | Fry |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mark Fry (Marco Island, Florida) |
| ABSTRACT | In an example, a sample collection apparatus to collect sample from a detection subject includes a circumferential ring tubing surrounding an interior and configured to be moved between bottom ring tubing position and top ring tubing position. The circumferential ring tubing includes air nozzles along a circumferential length of the ring tubing to direct air flow toward the interior as the ring tubing is moved from the top ring tubing position to the bottom ring tubing position, to blow air toward the detection subject in a sample collection zone in the interior and to push a sample of the detection subject via an air flow toward a platform on which the detection subject is positioned. The sample includes particles and/or vapor of the detection subject. A receptacle is disposed below the platform to collect the sample carried by the air flow through collection openings of the platform to the receptacle. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/210326 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 1/2211 (20130101) Original (OR) Class G01N 1/2247 (20130101) G01N 2001/024 (20130101) G01N 2001/2223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220121461 | YEGNESWARAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SRI International (Menlo Park, California); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinod YEGNESWARAN (Foster City, California); Ashish GEHANI (Atherton, California); Hassaan IRSHAD (Union City, California); Xutong CHEN (Evanston, Illinois); Yan CHEN (Northfield, Illinois) |
| ABSTRACT | Embodiments consistent with the present disclosure provide systems and methods for providing namespace-aware provenance tracking in a containerized environment. In some embodiments, methods for providing namespace-aware provenance tracking in a containerized environment may include monitoring, by one or more custom kernel hooks, event audit records from an OS kernel, wherein the one or more custom kernel hooks extend the functionality of the OS kernel; augmenting the event audit records from the OS kernel with one or more additional namespace aware audit records that include namespace information related to the container associated with event audit records, wherein the namespace information related to the container includes namespace IDs; processing, by an audit reporter, the namespace aware audit records to interpret the namespace IDs contained within the namespace aware audit records; and creating namespace-aware provenance graph that is namespace and container aware based on the namespace aware audit records. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/505018 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/455 (20130101) Original (OR) Class G06F 11/302 (20130101) G06F 11/3495 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220120983 | LEIGH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KEVIN B. LEIGH (Houston, Texas); LUCA RAMINI (Cernusco sul Naviglio (MIlan), Italy); MIR ASHKAN SEYEDI (Milpitas, California); MARCO FIORENTINO (Milpitas, California) |
| ABSTRACT | An photonic circuit includes a substrate, a plurality of first light waveguides disposed on the substrate, the first light waveguides extending in a first direction, a plurality of second light waveguides disposed on the substrate and extending in a second direction intersecting the first direction, and a plurality of first micro-ring resonators disposed on the substrate. Each of the first light waveguides has an intersection with each of the second light waveguides. Each of the intersections is provided with a first micro-ring resonator of the first micro-ring resonators. Each first micro-ring resonator is configured to route signals of a respective wavelength from one of the light waveguides at the intersection to another light waveguide at the intersection. |
| FILED | Monday, October 19, 2020 |
| APPL NO | 17/074472 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4215 (20130101) Original (OR) Class G02B 6/29343 (20130101) Transmission H04B 10/801 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220123159 | Yuan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuan Yuan (Milpitas, California); Zhihong Huang (Milpitas, California); Di Liang (Santa Barbara, California); Xiaoge Zeng (Milpitas, California) |
| ABSTRACT | Integrated optical filter and photodetectors and methods of fabrication thereof are described herein according to the present disclosure. An example of an integrated optical filter and photodetector described herein includes a substrate, an insulator layer on the substrate, and a semiconductor layer on the insulator layer. An optical filter having a resonant cavity is formed in or on the semiconductor layer. The integrated optical filter and photodetector further includes two first metal fingers and a second metal finger interdigitated between the two first metal fingers on the semiconductor layer forming Schottky barriers. The first metal fingers are constructed from a different metal relative to the second metal finger. |
| FILED | Friday, October 16, 2020 |
| APPL NO | 17/073152 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/4215 (20130101) G02B 6/29338 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1446 (20130101) H01L 31/1085 (20130101) H01L 31/1804 (20130101) H01L 31/02327 (20130101) Original (OR) Class Transmission H04B 10/25 (20130101) H04B 10/61 (20130101) H04B 10/516 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220119797 | MELOSH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas A. MELOSH (Menlo Park, California); Yuhong CAO (Palo Alto, California); Karl Martin HJORT (Lund, Sweden); Amanda JONSSON (Stanford, California) |
| ABSTRACT | Methods and apparatuses to non-destructively and periodically sample a small quantity of intracellular proteins and mRNA from the same single cell or cells for an extended period of time. Specifically, describe herein are non-perturbative methods for time-resolved, longitudinal extraction and quantitative measurement of intracellular proteins and nucleic acids from a variety of cell types using systems including nanostraws. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/460129 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Apparatus for Enzymology or Microbiology; C12M 33/04 (20130101) C12M 35/02 (20130101) C12M 41/38 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) C12N 15/1003 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220118024 | Frank et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia); Schepens Eye Research Institute (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The United States of America as represented by the Department of Veterans Affairs (Washington, District of Columbia); Schepens Eye Research Institute (Boston, Massachusetts); Children's Medical Center Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Markus H. Frank (Cambridge, Massachusetts); Natasha Y. Frank (Cambridge, Massachusetts); Bruce Ksander (Boston, Massachusetts); Paraskevi Evi Kolovou (Boston, Massachusetts) |
| ABSTRACT | Various aspects and embodiments of the present invention are directed to methods of treating a subject having an ocular condition, methods of isolating ocular stem cells, methods of selecting and/or producing ocular grafts for transplantation, and methods of promoting ocular cell regeneration as well as to grafts and preparations containing isolated ocular stem cells characterized by the expression of ABCB5 on their cell surface. |
| FILED | Monday, September 27, 2021 |
| APPL NO | 17/486855 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0051 (20130101) A61K 35/30 (20130101) Original (OR) Class Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3834 (20130101) A61L 27/3839 (20130101) A61L 2430/16 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0621 (20130101) C12N 5/0623 (20130101) C12N 5/0668 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220119982 | Herrington et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Voxel Innovations, Inc. (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Herrington (Raleigh, North Carolina); Eric Rountree (Raleigh, North Carolina) |
| ABSTRACT | A technique of removing material from metal parts referred to as OPECM and a corresponding OPECM processing machine are disclosed. A tool electrode is manufactured for removing material from a target workpiece, and the workpiece and tool electrode are fixed into a processing machine that imparts an oscillatory motion path or profile and applies a voltage through a flowing electrolyte solution. The disclosed technique and processing machine removes material from the surface of the target workpiece through proximal surface dissolution as the workpiece and tool electrode are brought within proximity of one another. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/565817 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/62 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/20 (20200101) B33Y 80/00 (20141201) Processes for the Electrolytic Removal of Materials From Objects; Apparatus Therefor C25F 3/16 (20130101) C25F 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220120488 | ROPER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. ROPER (Richmond, Virginia); Karl HAYTER (Richmond, Virginia); Michael BEIRO (Richmond, Virginia); Hooman TAFRESHI (Richmond, Virginia); Hossain AZIZ (Richmond, Virginia) |
| ABSTRACT | A secure refrigerated storage unit is provided. The lockable refrigerated medical storage unit (e.g. refrigerator) is used for the storage of medicines, vaccines or other valuable products that must be stored in the cold. The unit is equipped with compartments with individual temperature and content (e.g. weight) sensors, and the unit is connected to a computerized controller so that the temperature, contents and status (e.g. locked or unlocked) can be continually monitored and tracked. The internal temperature of the compartments is kept constant due to ventilation provided by strategically placed perforations in the compartments and shelves on which they are placed. |
| FILED | Friday, January 10, 2020 |
| APPL NO | 17/421429 |
| CURRENT CPC | Tables; Desks; Office Furniture; Cabinets; Drawers; General Details of Furniture A47B 67/02 (20130101) A47B 88/969 (20170101) Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 13/02 (20130101) Original (OR) Class F25D 25/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, April 21, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
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THE PANEL
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FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
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FILED
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APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-patents-20220421.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page