FedInvent™ Patent Applications
Application Details for Thursday, April 28, 2022
This page was updated on Tuesday, May 03, 2022 at 08:42 PM GMT
Department of Health and Human Services (HHS)
| US 20220125057 | BELFORT et al. |
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| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (TROY, New York); HEALTH RESEARCH, INC. (MENANDS, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (TROY, New York); HEALTH RESEARCH, INC. (MENANDS, New York) |
| INVENTOR(S) | Georges BELFORT (Albany, New York); C. Seth PEARSON (Albany, New York); Brian MURRAY (Haverhill, New York); Pankaj Sakharam KARANDE (Troy, New York); Jun Ha KWAK (Troy, New York); Kathleen A. MCDONOUGH (Albany, New York); Zachary Andrew KLOOS (New Haven, Connecticut) |
| ABSTRACT | Disclosed herein are novel anti-microbial peptides with inhibitory activity against M. tuberculosis and streptococcus bacteria. Additionally, a method for designing novel anti-microbial peptides is disclosed. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523079 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/38 (20130101) A01N 63/50 (20200101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/10 (20130101) A61K 45/06 (20130101) Peptides C07K 7/08 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125302 | Buckland et al. |
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| FUNDED BY |
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| APPLICANT(S) | Bioptigen, Inc (Morrisville, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric L. Buckland (Hickory, North Carolina); Al-Hafeez Dhalla (Durham, North Carolina); Robert H. Hart (Cary, North Carolina) |
| ABSTRACT | Methods are provided for performing a surgical procedure using optical coherence tomography (OCT) including extracting lenticular material from within a capsular bag of the eye of a patient; placing a replacement lens within the capsular bag after extraction of the lenticular material from the capsular bag; acquiring a plurality of OCT images that visualize the placement of the replacement lens within the capsular bag; and determining from the plurality of OCT images a degree of contact of the posterior surface of the replacement lens with the posterior portion of the capsular bag. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/568773 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/0041 (20130101) A61B 3/102 (20130101) Original (OR) Class A61B 3/103 (20130101) A61B 3/107 (20130101) A61B 3/1005 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/16 (20130101) A61F 2009/00851 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125312 | Nazari et al. |
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| FUNDED BY |
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| APPLICANT(S) | Integrated Medical Sensors, Inc. (Irvine, California) |
| ASSIGNEE(S) | Integrated Medical Sensors, Inc. (Irvine, California) |
| INVENTOR(S) | Meisam Honarvar Nazari (Irvine, California); Muhammad Mujeeb-U-Rahman (Irvine, California); Mehmet Sencan (Tustin, California) |
| ABSTRACT | Monitoring of one or more key indicators can provide powerful insights into operation and state of different physical systems. For example, continuous monitoring of multiple analyte in body will allow for detailed insights into personal health and will allow for preventative health management. In this application, we present an ultra-small scale wireless sensing platform capable of long-term wireless in-vivo sensing. The key for extreme miniaturization lies in ultra-low-power compact design and lithographic integration of key system components. The key to low cost is using standard technologies and scalable manufacturing. For example, using standard semiconductor technologies for sensing, processing and wireless operation paves way to a low-cost integrated wireless sensing technology. Modern semiconductor technologies provide the capability to provide low-power and yet powerful electronics functionality in a small (mm-scale) size and wireless operation at high frequency. Furthermore, these technologies also present the possibility of integrating different components through wafer-scale lithographic integration. This application presents optimal design and processing methods for a small wireless multi-analyte sensing platform that can be used to monitor multiple analyte such as glucose, lactate, Urea and other physicochemical quantities and operates wirelessly. The design techniques and processing methods presented in this application can be used for a multitude of other applications and are not limited to those described here. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/551093 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/002 (20130101) A61B 5/0031 (20130101) Original (OR) Class A61B 5/1473 (20130101) A61B 5/7275 (20130101) A61B 5/14532 (20130101) A61B 2560/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125314 | MEYER et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig H. MEYER (Charlottesville, Virginia); Xue FENG (Charlottesville, Virginia); Michael SALERNO (Charlottesville, Virginia) |
| ABSTRACT | A computerized system and method of modeling myocardial tissue perfusion can include acquiring a plurality of original frames of magnetic resonance imaging (MRI) data representing images of a heart of a subject and developing a manually segmented set of ground truth frames from the original frames. Applying training augmentation techniques to a training set of the originals frame of MRI data can prepare the data for training at least one convolutional neural network (CNN). The CNN can segment the training set of frames according to the ground truth frames. Applying the respective input test frames to a trained CNN can allow for segmenting an endocardium layer and an epicardium layer within the respective images of the input test frames. The segmented images can be used in calculating myocardial blood flow into the myocardium from segmented images of the input test frames. |
| FILED | Wednesday, February 05, 2020 |
| APPL NO | 17/428832 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0044 (20130101) Original (OR) Class A61B 5/055 (20130101) A61B 5/0263 (20130101) A61B 5/7267 (20130101) A61B 2576/023 (20130101) Measuring Electric Variables; Measuring Magnetic Variables G01R 33/4835 (20130101) G01R 33/56366 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 3/0006 (20130101) G06T 3/60 (20130101) G06T 7/11 (20170101) G06T 7/0014 (20130101) G06T 7/33 (20170101) G06T 7/143 (20170101) G06T 7/149 (20170101) G06T 7/194 (20170101) G06T 7/215 (20170101) G06T 2207/10088 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30048 (20130101) G06T 2207/30104 (20130101) G06T 2207/30168 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125324 | BERSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ROBERT ERIC BERSON (Louisville, Kentucky); SHAHAB GHAFGHAZI (Louisville, Kentucky); JAVAD HASHEMI (Louisville, Kentucky) |
| ABSTRACT | A non-invasive method of assessing a coronary stenosis or other blockage in an artery or other vasculature is based on determination of a blood flow characteristic. In some embodiments, the blood flow characteristic is a fractional flow reserve determined using a statistical correlation of experimentally determined physiological factors and anatomical factors. In other embodiments, the blood flow characteristic is a blood flow rate determined using machine learning techniques. In further embodiments, the blood flow rate determined using machine learning techniques is a physiological factor used in determining the fractional flow reserve. |
| FILED | Monday, February 10, 2020 |
| APPL NO | 17/428086 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/021 (20130101) A61B 5/024 (20130101) A61B 5/029 (20130101) Original (OR) Class A61B 5/02028 (20130101) A61B 5/7264 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125386 | Marras et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William S. Marras (Powell, Ohio); Jonathan Dufour (Columbus, Ohio); Alexander Aurand (Columbus, Ohio); Prasath Mageswaran (Columbus, Ohio); Gregory Knapik (Columbus, Ohio) |
| ABSTRACT | An integrated and holistic system that delivers clinical decision support, disorder prevention, and research services for chronic disorders is provided. In one embodiment, the system collects a variety of data about an individual including data from one or more of wearable motion sensors, self-reported questionnaires, medical imaging, and electronic medical records. A historical database of outcomes and similar data for other individuals is processed using advanced statistics, artificial intelligence, and machine learning to identify biomarkers and phenotypes that are indicative of outcomes with respect to zero or more interventions. The collected individual's data is then analyzed with respect to the identified biomarkers or phenotypes to predict outcomes with respect to zero or more interventions for the individual. The individual, and/or an associated agent, may then consider the predicted outcomes when selecting an intervention plan for the individual and monitor intervention impact over time. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458756 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1116 (20130101) A61B 5/7275 (20130101) Original (OR) Class A61B 2503/24 (20130101) A61B 2562/0219 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 10/60 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125395 | Burbar et al. |
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| FUNDED BY |
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| APPLICANT(S) | Siemens Medical Solutions USA, Inc. (Malvern, Pennsylvania); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ziad Burbar (Knoxville, Tennessee); Inki Hong (Knoxville, Tennessee); Stefan B. Siegel (Knoxville, Tennessee); Joel Karp (Glenside, Pennsylvania) |
| ABSTRACT | A medical imaging and/or radiotherapy apparatus incorporates a display for projecting a visible image to a patient lying on a patient table. A projector that projects the visible image moves in tandem with the patient table, so that it appears relatively motionless to the patient. In exemplary embodiments, the projector projects the visible image within a patient tunnel of the medical apparatus, including in some embodiments, an extended field of view medical imaging apparatus. In other exemplary embodiments, the projector projects the visible image on a screen above the patient table of a tunnel-less medical apparatus. The projector remains outside the imaging line of response of detectors within the imaging field or outside of the radiotherapy beam zone, to avoid potential degradation of the captured diagnostic image or degradation of the radiotherapy beam. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 16/949296 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/0407 (20130101) A61B 6/461 (20130101) Original (OR) Class A61B 6/4447 (20130101) A61B 6/4458 (20130101) A61B 6/5235 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125514 | Zharov et al. |
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| FUNDED BY |
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| APPLICANT(S) | Bioventures, LLC (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Pavlovich Zharov (Little Rock, Arkansas); Ekaterina Galanzha (Little Rock, Arkansas) |
| ABSTRACT | A device and method of using the device to detect the presence and composition of clots and other target objects in a circulatory vessel of a living subject is described. In particular, devices and methods of detecting the presence and composition of clots and other target objects in a circulatory vessel of a living subject using in vivo photoacoustic flow cytometry techniques is described. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/496995 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 5/0095 (20130101) A61B 5/412 (20130101) A61B 5/415 (20130101) A61B 5/416 (20130101) A61B 5/418 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/1495 (20130101) A61B 5/02007 (20130101) A61B 5/4839 (20130101) A61B 5/7282 (20130101) A61B 5/7405 (20130101) A61B 5/7455 (20130101) A61B 5/14535 (20130101) A61B 8/06 (20130101) A61B 8/08 (20130101) A61B 8/481 (20130101) A61B 18/245 (20130101) Original (OR) Class A61B 18/1815 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/22 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/30 (20130101) B03C 1/288 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/1702 (20130101) G01N 29/2418 (20130101) G01N 29/4427 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125728 | Minko et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Tamara Minko (East Brunswick, New Jersey); Olga B. Garbuzenko (Skillman, New Jersey) |
| ABSTRACT | A nanocarrier containing a combination of bioactive agents is provided. The nanocarrier allows for targeted delivery of the agents to cancer cells with minimized side effect. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508535 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0078 (20130101) A61K 9/1272 (20130101) Original (OR) Class A61K 31/277 (20130101) A61K 31/282 (20130101) A61K 31/337 (20130101) A61K 31/365 (20130101) A61K 31/506 (20130101) A61K 31/517 (20130101) A61K 31/553 (20130101) A61K 31/704 (20130101) A61K 31/5377 (20130101) A61K 33/243 (20190101) A61K 47/64 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125736 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Wang (Chapel Hill, North Carolina); Yu Mi (Chapel Hill, North Carolina) |
| ABSTRACT | In one aspect, methods are described herein employing particle compositions operable to form composite membrane for inhibition of post-surgical adhesions. Briefly, a method of treating a surgical site comprises contacting the surgical site with a particle formulation comprising targeting particles and scaffolding particles. The targeting particles and scaffolding particles are crosslinked to provide a composite membrane at the surgical site, wherein formation of post-surgical adhesions are inhibited by the composite membrane. |
| FILED | Thursday, February 06, 2020 |
| APPL NO | 17/428843 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) Original (OR) Class A61K 31/573 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 41/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125744 | Das |
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| FUNDED BY |
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| APPLICANT(S) | Health Research, Inc. (Buffalo, New York) |
| ASSIGNEE(S) | Health Research, Inc. (Buffalo, New York) |
| INVENTOR(S) | Gokul M. Das (Buffalo, New York) |
| ABSTRACT | To induce cancer cell death, cancer cells are selected that express estrogen-receptor β (ERβ) and mutant tumor protein 53 (TP53). An agent that increases ERβ protein expression is administered to the cells to induce cell death. To treat a subject having a cancer that is characterized by cancer cells expressing ERβ and mutant TP53, an agent that increases ERβ protein expression is administered to induce cell death in the cancer cells. To increase estrogen receptor β (ERβ) expression levels in a subject having low ERβ expression levels, tamoxifen is administered to increase ERβ protein levels in the subject. To treat a subject having cancer cells expressing estrogen-receptor β (ERβ) and wildtype tumor protein 53 (TP53), an agent that inhibits ERβ and TP53 binding interaction is administered to induce cell death in the cancer cells of the subject. |
| FILED | Thursday, November 07, 2019 |
| APPL NO | 17/291211 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/138 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125746 | YU et al. |
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| FUNDED BY |
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| APPLICANT(S) | Jian YU (Pittsburgh, Pennsylvania); Lin ZHANG (Pittsburgh, Pennsylvania); Brian LEIBOWITZ (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jian YU (Pittsburgh, Pennsylvania); Lin ZHANG (Pittsburgh, Pennsylvania); Brian LEIBOWITZ (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are compositions and methods for preventing or treating gastrointestinal injury induced by chemotherapy or radiotherapy. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 17/428632 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/16 (20130101) Original (OR) Class A61K 31/63 (20130101) A61K 31/341 (20130101) A61K 31/495 (20130101) A61K 31/506 (20130101) A61K 31/4985 (20130101) A61K 31/5375 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125749 | Apkarian et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois); The University of Notre Dame Du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | A. Vania Apkarian (Chicago, Illinois); Kasturi Haldar (Chicago, Illinois); Suhail Alam (Mishawaka, Indiana); Maria Virginia Centeno (Chicago, Illinois) |
| ABSTRACT | The disclosure relates to use of a triple formulation comprising a histone deacytlase, a cyclodextrin and polyethylene glycol or propylene glycol, and in the treatment and management of chronic pain. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/568477 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/167 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/10 (20130101) A61K 47/40 (20130101) A61K 47/60 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/02 (20180101) A61P 25/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125774 | CHOU et al. |
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| FUNDED BY |
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| APPLICANT(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| ASSIGNEE(S) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (Charleston, South Carolina) |
| INVENTOR(S) | James C. CHOU (Mt. Pleasant, South Carolina); Sherine S.L. CHAN (Charleston, South Carolina); Richard A. HIMES (Charleston, South Carolina) |
| ABSTRACT | Compounds and methods are provided for the treatment of neurological or mitochondrial diseases, including epilepsy. In some embodiments, the compounds are substituted 1,4-naphthoquinones. |
| FILED | Monday, July 29, 2019 |
| APPL NO | 17/264714 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/136 (20130101) A61K 31/4406 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/08 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125778 | Tavares et al. |
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| FUNDED BY |
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| APPLICANT(S) | SYMBERIX, INC. (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Francis X. Tavares (Durham, North Carolina); Bret D. WALLACE (Durham, North Carolina); Ward PETERSON (Morrisville, North Carolina) |
| ABSTRACT | The present disclosure describes compounds and compositions that inhibit β-glucuronidase activity, and methods for attenuating the side effects of one or more drugs and improving the efficacy of drugs by administration of selective β-glucuronidase inhibitors. |
| FILED | Friday, March 06, 2020 |
| APPL NO | 17/436246 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/706 (20130101) A61K 31/4704 (20130101) Original (OR) Class A61K 31/4709 (20130101) Heterocyclic Compounds C07D 215/227 (20130101) C07D 401/12 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125779 | Carver |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chase Carver (San Antonio, Texas) |
| ABSTRACT | Certain embodiments are directed to methods and compositions for treating or preventing seizures in a subject using a therapeutic agent comprising one or more Transient Receptor Potential-Canonical 4/5 channel antagonists sufficient to regulate excitability of neurons in the brain of a subject. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185031 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4184 (20130101) A61K 31/4709 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125812 | BURNS et al. |
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| FUNDED BY |
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| APPLICANT(S) | VenatoRx Pharmaceuticals, Inc. (Malvern, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher J. BURNS (Malvern, Pennsylvania); Denis DAIGLE (Street, Maryland); Jodie HAMRICK (New Holland, Pennsylvania); Daniel C. PEVEAR (Downingtown, Pennsylvania); Robert E. Lee TROUT (Collegeville, Pennsylvania); Luigi XERRI (Wayne, Pennsylvania); Timothy HENKEL (Malvern, Pennsylvania); Cullen L. MYERS (Exton, Pennsylvania); Stephen M. CONDON (Glenmoore, Pennsylvania); Anthony DRAGER (Thorndale, Pennsylvania); Lawrence ROSEN (Wayne, Pennsylvania) |
| ABSTRACT | The present invention relates to pharmaceutical compositions containing boron-containing compounds and their use as inhibitors of beta-lactamase enzymes and as antibacterial agents in combination with a beta-lactam antibiotic. |
| FILED | Friday, November 22, 2019 |
| APPL NO | 17/296371 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/69 (20130101) Original (OR) Class A61K 31/545 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125814 | Hockenbery et al. |
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| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| INVENTOR(S) | David Hockenbery (Seattle, Washington); Patrick Paddison (Seattle, Washington) |
| ABSTRACT | Cancer combination therapies utilizing a nicotinamide phosphoribosyltransferase (NAMPT) inhibitor in combination with a nicotinamide adenine dinucleotide (NAD) salvage pathway precursor are described. Cancers treated with the combination therapies can be nicotinamide riboside kinase (NMRK1) low cancers and/or Myc high cancers and can include various forms of glioblastomas. |
| FILED | Friday, March 20, 2020 |
| APPL NO | 17/441599 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/706 (20130101) Original (OR) Class A61K 31/4409 (20130101) A61K 31/4439 (20130101) A61K 31/4545 (20130101) A61K 31/4725 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125816 | Davies |
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| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daryl Davies (Los Angeles, California) |
| ABSTRACT | Provided herein are methods to improve transport or uptake of an avermectin compound in a cell or tissue expressing an efflux transporter P-glycoprotein (Pgp) by co-administering an effective amount of the avermectin compound and a Ppg inhibitor to the cell or tissue. The method also provides improved efficiency transport or uptake of an avermectin compound in the cell or tissue. The methods can be used therapeutically to treat Alcohol Use Disorder. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/507507 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/365 (20130101) A61K 31/4725 (20130101) A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/32 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125820 | Mitragotri et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Samir Mitragotri (Lexington, Massachusetts); Marta Broto (Barcelona, Spain); Kathryn M. Camacho (Los Angeles, California); Stefano Menegatti (Raleigh, North Carolina) |
| ABSTRACT | Compounds and pharmaceutical formulations containing these compounds are described. Also described are methods of making and using the compounds. The compounds include nucleobases, nucleobase analogues, or combinations thereof. In one embodiment, a nucleobase analogue is combined with doxorubicin and encapsulated within a liposome for use in inhibiting or preventing the growth of cancer cells. Further described are pharmaceutical compositions containing two or more therapeutically active agents encapsulated within a vesicle, such as a liposome, wherein the molar ratio of the agents provides a synergistic therapeutic effect. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/517826 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1273 (20130101) A61K 31/506 (20130101) A61K 31/513 (20130101) A61K 31/7072 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125822 | Vaidya et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Brigham and Women`s Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vishal S. Vaidya (Cambridge, Massachusetts); Casimiro Gerarduzzi (Boston, Massachusetts) |
| ABSTRACT | Described herein are methods for treating fibrosis, e.g., kidney fibrosis, using agents that target Secreted Modular Calcium-binding protein 2 (SMOC2). |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/645762 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/712 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) A61P 43/00 (20180101) Peptides C07K 16/18 (20130101) C07K 16/2842 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125838 | Oh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Seoul National University R and DB Foundation (Seoul, South Korea) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Seoul National University R and DB Foundation (Seoul, South Korea) |
| INVENTOR(S) | Sungwhan Oh (Cambridge, Massachusetts); Dennis L. Kasper (Cambridge, Massachusetts); Heebum Song (Seoul, South Korea); Seung Bum Park (Arlington, Massachusetts) |
| ABSTRACT | Provided herein are a subset of alpha-galactosylceramide (alpha-GC) compounds having improved immunomodulatory activity, particularly with respect to NKT cell number and activity. Also provided herein are methods of use of such compounds, including in the modulation of NKT cells and/or activity in vivo. Further provided are combinatorial synthesis methods for generating alpha-GC compounds of specifically defined structure and thereby generating pure preparations thereof. |
| FILED | Wednesday, January 15, 2020 |
| APPL NO | 17/427756 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/549 (20170801) A61K 47/6425 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 15/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125839 | SARNAIK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amod SARNAIK (Tampa, Florida); Dmitri I. GABRILOVICH (Villanova, Pennsylvania) |
| ABSTRACT | Approximately 50% of melanoma patients carry a mutation in the BRAF protein. Targeted therapy with inhibitors of BRAF and the downstream pathway is very effective in these patients, but long-term benefits are limited due to the onset of therapy resistance. Previous studies demonstrated that BRAF inhibitors (BRAFi) positively affect the antitumor immune response mediated by T cells. Disclosed are methods of treating, preventing, inhibiting, reducing, and/or ameliorating a cancer and/or metastasis in a subject using an adoptive T cell therapy, the method comprising administering to the subject a BRAF inhibitor (BRAFi) (such as, for example, sorafenib, vemurafenib, dabrafenib, and/or encorafenib) and an adoptive T cell therapy, wherein administration of the BRAF inhibitor increases insulin-like growth factor II receptor (IGF2R). |
| FILED | Thursday, February 13, 2020 |
| APPL NO | 17/430331 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/137 (20130101) A61K 31/506 (20130101) A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125842 | O'Malley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/446282 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125843 | Moriarity et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota); Intima Bioscience, Inc. (New York, New York); The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Branden Moriarity (Shoreview, Minnesota); Beau Webber (Coon Rapids, Minnesota); Modassir Choudhry (New York, New York); R. Scott McIvor (St. Louis Park, Minnesota); David Largaespada (Mounds View, Minnesota); Steven A. Rosenberg (Potomac, Maryland); Douglas C. Palmer (North Bethesda, Maryland); Nicholas P. Restifo (Chevy Chase, Maryland) |
| ABSTRACT | Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/478615 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Peptides C07K 14/4718 (20130101) C07K 14/7051 (20130101) C07K 14/7158 (20130101) C07K 14/70503 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/87 (20130101) C12N 15/113 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125849 | YANG |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ALBANY MEDICAL COLLEGE (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qi YANG (Glenmont, New York) |
| ABSTRACT | The present disclosure relates to a method of improving cognitive function in a subject. The method includes implanting group-2 innate lymphoid cells (ILC2) in a cranium of a subject, where the ILC2 was treated with an ILC2 activator. The present disclosure further relates to a method including selecting a subject having aging-associated cognitive decline and administering to the subject an activator of innate lymphoid cell activity under conditions effective to promote innate lymphoid cell activity. The present disclosure further relates to a method of improving cognition in a subject. The method includes selecting a subject having aging-associated cognitive decline and administering to the subject a cytokine selected from the group consisting of IL-33, IL-5, IL-7, IL-25, and thymic stromal lymphopoietin. |
| FILED | Friday, March 20, 2020 |
| APPL NO | 17/441613 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0024 (20130101) A61K 31/202 (20130101) A61K 31/5575 (20130101) A61K 35/26 (20130101) Original (OR) Class A61K 35/741 (20130101) A61K 38/19 (20130101) A61K 38/20 (20130101) A61K 38/2033 (20130101) A61K 38/2046 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125873 | BIROL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PROVINCIAL HEALTH SERVICES AUTHORITY (Vancouver, Canada); UVIC INDUSTRY PARTNERSHIPS INC. (Victoria, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Inanc BIROL (Vancouver, Canada); Caren C. HELBING (Victoria, Canada); Stewart Austin HAMMOND (Saskatoon, Canada) |
| ABSTRACT | Antimicrobial peptides (AMPs), small compounds that often exhibitbroad spectrum antimicrobial activity, are garnering interest as potential therapeutics against antibiotic-resistant bacterial pathogens. Development of new AMPs is arduous due to the practical limitations of classical protein-based discovery approaches. A high throughput bioinformatics approach is described which is able to confirm identification of known AMPs from the North American bullfrog (Rana (Lithobates) catesbeiana) genome, and a bioinformatics approach is used to develop new AMPs. The described AMPs exhibit antimicrobial activity against Mycobacterium smegmatis via microtitre broth dilution assays, indicating broader efficacy. |
| FILED | Tuesday, December 10, 2019 |
| APPL NO | 17/312806 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/1703 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5011 (20130101) G01N 33/56911 (20130101) G01N 2500/04 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125878 | Xia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Oklahoma Medical Research Foundation (Oklahoma City, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lijun Xia (Edmond, Oklahoma); Yuji Kondo (Oklahoma City, Oklahoma) |
| ABSTRACT | The present invention includes methods for treating and/or preventing a viral or virally-induced tissue dysfunction or failure in a patient comprising administering an inhibitor of SARS-CoV-2 binding to L-SIGN in an amount effective to treat the viral or virally-induced tissue dysfunction or failure of cells do not express ACE2. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506370 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/715 (20130101) A61K 38/178 (20130101) Original (OR) Class Peptides C07K 16/2851 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125890 | ZUCHNER et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Miami (Miami, Florida); University of Rochester (Rochester, New York); UCL Business LTD (London, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephan L. ZUCHNER (Miami, Florida); Adriana REBELO (Miami, Florida); Andrea CORTESE (London, United Kingdom); Rong Grace ZHAI (Miami, Florida); David N. HERRMANN (Rochester, New York) |
| ABSTRACT | The present disclosure relates to methods of detecting and treating inherited neuropathy. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/517227 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/198 (20130101) A61K 31/352 (20130101) A61K 31/426 (20130101) A61K 31/428 (20130101) A61K 31/473 (20130101) A61K 31/499 (20130101) A61K 31/502 (20130101) A61K 31/517 (20130101) A61K 31/4184 (20130101) A61K 31/4188 (20130101) A61K 31/7105 (20130101) A61K 38/443 (20130101) Original (OR) Class A61K 38/465 (20130101) A61K 48/005 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0006 (20130101) C12N 15/86 (20130101) C12N 15/1137 (20130101) C12N 2310/11 (20130101) C12N 2750/14143 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) C12Q 2600/156 (20130101) Enzymes C12Y 101/01014 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/66 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125893 | Finlayson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Splash Pharmaceuticals, Inc. (San Diego, California); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Malcolm Finlayson (San Diego, California); David Nelson (San Diego, California); Monica Guma (La Jolla, California) |
| ABSTRACT | This invention relates to methods of treatment for arthritis using SPL-108 polypeptide. In particular, this invention relates to such methods of treatment by the administration of an SPL-108 polypeptide (also known as A6 peptide, a CD44 modulating peptide) or a variant thereof alone or in combination with a standard-of-care treatment for arthritis to alleviate and/or prevent symptoms of arthritis and/or to avoid side effects commonly associated with treating arthritis. Such methods of the present invention are used to treat inflammatory conditions such as rheumatoid arthritis, osteoarthritis, reactive arthritis, and/or psoriatic arthritis. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526776 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/482 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6408 (20130101) Enzymes C12Y 304/21031 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125920 | Leeper et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas J. Leeper (Stanford, California); Irving L. Weissman (Stanford, California) |
| ABSTRACT | An effective combined dose of an anti-CD47 agent and an anti-TNFα agent is administered to the subject in a dose and for a period of time effective to stabilize, prevent or reduce atherosclerotic plaque in the individual. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575438 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/17 (20130101) A61K 38/179 (20130101) A61K 38/1709 (20130101) A61K 38/1793 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/10 (20180101) Peptides C07K 16/241 (20130101) C07K 16/2803 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125930 | Kaplan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Ilia A. Rodionov (Medford, Massachusetts) |
| ABSTRACT | A method of making drug-eluting regenerated silk fibroin particles using cryogranulation. The method has a first step of injecting a mixture into a super-cooled fluid, the mixture including regenerated silk fibroin and at least one medicament. A second step of incubating the drug-eluting particles in the super-cooled fluid to promote cryogelation may also be used. The size distribution, morphology, and cross-linking efficiency of the particles can depend on several controllable variable, such as starting concentrations of cross-linking agents and silk fibroin in the mixture, the injection pressure, and the temperature of the super-cooled fluid. |
| FILED | Wednesday, February 12, 2020 |
| APPL NO | 17/310586 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/4825 (20130101) A61K 9/4833 (20130101) A61K 45/06 (20130101) A61K 47/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125948 | KAY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeremy KAY (Durham, North Carolina); Thomas RAY (Durham, North Carolina) |
| ABSTRACT | The present invention provides compositions and methods related to the cell surface protein CRB1 for the treatment of retinopathies in a subject, as well as systems and kits employing such compositions. |
| FILED | Wednesday, March 04, 2020 |
| APPL NO | 17/436419 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125949 | Hinderer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christian Hinderer (Baltimore, Maryland); James M. Wilson (Philadelphia, Pennsylvania) |
| ABSTRACT | A suspension useful for AAV9-mediated intrathecal and/or systemic delivery of an expression cassette containing a hIDS gene is provided herein. Also provided are methods and kits containing these vectors and compositions useful for treating Hunter syndrome and the symptoms associated with Hunter syndrome. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/573883 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) Original (OR) Class A61K 48/0075 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 15/85 (20130101) C12N 15/86 (20130101) C12N 15/113 (20130101) C12N 2750/14143 (20130101) C12N 2800/22 (20130101) C12N 2830/15 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) Enzymes C12Y 301/06013 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125952 | Kaspar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NATIONWIDE CHILDREN'S HOSPITAL, INC. (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian K. Kaspar (Columbus, Ohio); Kevin Foust (Columbus, Ohio) |
| ABSTRACT | The present invention relates to Adeno-associated virus 9 methods and materials useful for systemically delivering polynucleotides across the blood brain barrier. Accordingly, the present invention also relates to methods and materials useful for systemically delivering polynucleotides to the central and peripheral nervous systems. The present invention also relates to Adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as spinal muscle atrophy and amyotrophic lateral sclerosis as well as Pompe disease and lysosomal storage disorders. Use of the methods and materials is also indicated, for example, for treatment of Rett syndrome. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573303 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/005 (20130101) A61K 48/0075 (20130101) Original (OR) Class Peptides C07K 14/47 (20130101) C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) C12N 2750/14121 (20130101) C12N 2750/14132 (20130101) C12N 2750/14143 (20130101) C12N 2830/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126257 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ruixuan Gao (Cambridge, Massachusetts); Ishan Gupta (Cambridge, Massachusetts); Edward S. Boyden (Chestnut Hill, Massachusetts) |
| ABSTRACT | A method for synthesizing nanoparticles by sonofragmentation includes dispersing ultra-thin substrate units in a solvent chosen for suitability for sonofragmentation of the substrate, forming a suspension; ultrasonicating the suspension for a length of time sufficient to fragment the substrate into nanoparticles that are dispersed in the solvent; and evaporating the solvent. Solvent exchange with a second solvent may be performed. The synthesized nanoparticles are highly crystalline and monodispersed. The surface of the synthesized nanoparticles may be functionalized by choosing the solvents according to chemistry related to the intended surface functionalization of the synthesized nanoparticles, by adding surfactants to one or more of the solvents, and/or by performing ligand exchange or chemical modification to replace surface-bonded solvent or surfactant molecules with other functional groups to produce nanoparticles having the desired surface functionalization. |
| FILED | Wednesday, September 01, 2021 |
| APPL NO | 17/464651 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/10 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126292 | Espinosa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NORTHWESTERN UNIVERSITY (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Horacio Dante Espinosa (Winnetka, Illinois); Milan Mrksich (Hinsdale, Illinois); Prithvijit Mukherjee (Evanston, Illinois); Eric Jason Berns (Naperville, Illinois); Cesar Andres Patino (Evanston, Illinois) |
| ABSTRACT | A cell analysis system includes a multi-layer microfluidic device that includes a layer of microfluidic channels, a layer of microwells, a membrane with nanochannels, and a layer of extraction chambers. The microwells and the membrane are configured to allow culturing of cells that are adhered to the membrane or suspended in the microwells, and the membrane is configured to allow diffusion of substances across the membrane into the layer of extraction chambers. The cell analysis system includes a top conductive layer and a bottom conductive layer on the opposite sides of the multi-layer microfluidic device. The cell analysis system also includes a function generator configured to apply an electroporation pulse between the top conductive layer and the bottom conductive layer. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511246 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502707 (20130101) B01L 3/502715 (20130101) Original (OR) Class B01L 3/502753 (20130101) B01L 2200/12 (20130101) B01L 2300/16 (20130101) B01L 2300/123 (20130101) B01L 2300/0663 (20130101) B01L 2300/0829 (20130101) B01L 2300/0887 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126370 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jian Liu (Cary, North Carolina); Shuang Bai (Cary, North Carolina) |
| ASSIGNEE(S) | PolarOnyx, Inc. (Chapel Hill, North Carolina) |
| INVENTOR(S) | Jian Liu (Cary, North Carolina); Shuang Bai (Cary, North Carolina) |
| ABSTRACT | Methods and apparatuses for AM of all-in-one radiation shielding components from multi-material metal alloys, metal matrix, MMCs, and/or gradated compositions of the same are disclosed, comprising: providing an apparatus having: an energy source; a scanner; a powder system for powder(s); a powder delivery system; a shielding gas; and a computer coupled to and configured to control the energy source, scanner, powder system, and powder delivery system to deposit layers of the sample; programming the computer with specifications of the sample; using the computer to control electromagnetic radiation, mixing ratio, and powder deposition parameters based on the specifications of the sample; and using the autofocusing scanner to focus and scan the electromagnetic radiation onto the sample while the powders are concurrently deposited by the powder delivery system onto the sample to create a melting pool to deposit one or more layers onto the sample. Other embodiments are described and claimed. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511073 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/062 (20220101) B22F 1/065 (20220101) B22F 1/068 (20220101) B22F 10/36 (20210101) Original (OR) Class B22F 10/85 (20210101) B22F 12/30 (20210101) B22F 12/49 (20210101) B22F 12/58 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127226 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Jau-Nian CHEN (Los Angeles, California); Ohyun KWON (Los Angeles, California); Jie HUANG (Los Angeles, California); Hirohito SHIMIZU (Los Angeles, California); Kui LU (Los Angeles, California); Johann SCHREDELSEKER (Los Angeles, California); Yi Chiao FAN (Los Angeles, California) |
| ABSTRACT | Agents, compositions, and methods for regulating cardiac rhythmicity are disclosed. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573442 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/40 (20130101) A61K 31/7088 (20130101) A61K 38/1709 (20130101) A61K 48/005 (20130101) Heterocyclic Compounds C07D 207/48 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127306 | KRISHNA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REALTA HOLDINGS, LLC (Norfolk, Virginia) |
| ASSIGNEE(S) | REALTA HOLDINGS, LLC (Norfolk, Virginia) |
| INVENTOR(S) | Neel K. KRISHNA (Norfolk, Virginia); Kenji CUNNION (Norfolk, Virginia) |
| ABSTRACT | The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated, purified peptide of 30 amino acids derived from human astrovirus protein, called CP1. The invention is directed to peptide compounds that are peptide mimetics, peptide analogs and/or synthetic derivatives of CP1 having, for example, internal peptide deletions and substitutions, deletions and substitutions at the N-terminus and C-terminus, and that are able to regulate complement activation. The invention further provides pharmaceutical compositions of therapeutically effective amounts of the peptide compounds and a pharmaceutically acceptable carrier, diluent, or excipient for treating a disease or condition associated with complement-mediated tissue damage. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/574098 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/03 (20130101) A61K 38/10 (20130101) A61K 38/162 (20130101) A61K 45/06 (20130101) Peptides C07K 7/08 (20130101) Original (OR) Class C07K 14/005 (20130101) C07K 14/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127308 | LIEBER et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andre LIEBER (Seattle, Washington); Hongjie WANG (Seattle, Washington) |
| ABSTRACT | The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues. |
| FILED | Wednesday, December 22, 2021 |
| APPL NO | 17/559391 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/42 (20130101) Peptides C07K 7/06 (20130101) C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0652 (20130101) C12N 7/00 (20130101) C12N 15/10 (20130101) C12N 15/86 (20130101) C12N 2710/10321 (20130101) C12N 2710/10322 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/94 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127313 | CHEUNG-FLYNN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joyce CHEUNG-FLYNN (Nashville, Tennessee); Colleen M. BROPHY (Nashville, Tennessee) |
| ABSTRACT | The present disclosure provides novel cell permeant polypeptides and pharmaceutical compositions thereof, and methods for using such polypeptides and pharmaceutical compositions for various therapeutic uses. The present disclosure more specifically provides polypeptides for restoring endothelial function. |
| FILED | Wednesday, February 12, 2020 |
| APPL NO | 17/430365 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 43/00 (20180101) Peptides C07K 14/4702 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127318 | PASZEK et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew PASZEK (Lansing, New York); Heidi REESINK (Lansing, New York) |
| ABSTRACT | Provided are compositions and methods related to modified lubricins, methods of making the modified lubricins, and methods of using the modified lubricins for coating a variety of inanimate objects, and for prophylaxis and/or therapy of disorders where enhanced lubrication of one or more parts of a human or non-human mammal is desirable. |
| FILED | Wednesday, January 15, 2020 |
| APPL NO | 17/422736 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 12/14 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 19/02 (20180101) Peptides C07K 14/4725 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127319 | PASZEK et al. |
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| FUNDED BY |
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| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew PASZEK (Lansing, New York); Heidi REESINK (Lansing, New York); Carolyn SHURER (Houston, Texas); Hao PAN (Ithaca, New York) |
| ABSTRACT | Provided are compositions and methods related to improved mucins, methods of making the improved mucins, and cells and cell cultures that express glycosylated mucins. The compositions and methods provide improved cell cultures, and improved methods of producing co-expressed proteins that are distinct from the mucins. |
| FILED | Wednesday, January 15, 2020 |
| APPL NO | 17/422740 |
| CURRENT CPC | Peptides C07K 14/4727 (20130101) Original (OR) Class C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127335 | LU et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wuyuan LU (Baltimore, Maryland); Bohan MA (Yanta District, Xi'an, China PRC) |
| ABSTRACT | A protein-based peptide drug carrier derived from the tetramerization domain of the chimeric oncogenic protein Bcr/Abl of chronic myeloid leukemia. Peptides to be delivered are grafted to the N-terminal helical region of Bcr/Abl tetramer. To facilitate cellular uptake, an Arg-repeating hexapeptide is added to the C-terminal end of the Bcr/Abl protein. The protein-based delivery strategy provides a clinically viable solution to p53-inspired anticancer therapy and is applicable to the development of many other peptide therapeutics to target other intracellular protein-protein interactions responsible for disease initiation and progression. |
| FILED | Friday, March 06, 2020 |
| APPL NO | 17/432568 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/82 (20130101) Original (OR) Class C07K 14/4746 (20130101) C07K 14/4747 (20130101) C07K 2319/03 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127347 | Kosik et al. |
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| FUNDED BY |
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| APPLICANT(S) | Kenneth Kosik (Santa Barbara, California); Jennifer Rauch (Amherst, Massachusetts) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Kenneth Kosik (Santa Barbara, California); Jennifer Rauch (Amherst, Massachusetts) |
| ABSTRACT | Provided are novel methods of inhibiting the propagation of pathological forms of tau between cells of the central nervous system by administration of an inhibitor of LRP1. LRP1 was discovered to facilitate the endocytosis of pathological forms of tau which enables the propagation of tau aggregates and resulting neurodegeneration. These methods enable the prevention and treatment of various tauopathies, such as Alzheimer's, chronic traumatic encephalopathy, corticobasal degeneration, and others. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511343 |
| CURRENT CPC | Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/20 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127367 | Dimitrov et al. |
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| FUNDED BY |
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| APPLICANT(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The U.S.A., as represented by the Secretary, Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Dimiter S. Dimitrov (Pittsburgh, Pennsylvania); Weizao Chen (Frederick, Maryland); Terry J. Fry (Aurora, Colorado); Christopher Chien (Falls Church, Virginia) |
| ABSTRACT | Human monoclonal antibodies that specifically bind Fms-like tyrosine kinase 3 (FLT3) are described. Chimeric antigen receptors (CARs) and other antibody conjugates that include the FLT3-specific monoclonal antibodies are also described. Methods for the diagnosis and treatment of FLT3-associated cancer, such as acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML), are further described. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/570248 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6849 (20170801) A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) A61P 35/04 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70578 (20130101) C07K 16/468 (20130101) C07K 16/2863 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/31 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/30 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127370 | Badley |
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| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| INVENTOR(S) | Andrew D. Badley (Rochester, Minnesota) |
| ABSTRACT | This document provides antibodies against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) short, and more particularly to humanized TRAILshort antibodies that can neutralize TRAILshort. For example, materials and methods for using one or more humanized TRAILshort antibodies to induce apoptosis (e.g., via TRAIL mediated cell death, natural killer (NK) cytotoxicity, and/or CD8+ T cell killing) are provided. |
| FILED | Tuesday, August 24, 2021 |
| APPL NO | 17/410832 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/191 (20130101) A61K 39/39558 (20130101) Peptides C07K 16/2875 (20130101) Original (OR) Class C07K 16/2878 (20130101) C07K 2317/24 (20130101) C07K 2317/73 (20130101) C07K 2317/75 (20130101) C07K 2317/76 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127373 | Lim et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); The Trustees of Princeton University (Princeton, New Jersey); The Simons Foundation, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wendell A. Lim (San Francisco, California); Olga G. Troyanskaya (Princeton, New Jersey); Benjamin Vandersluis (New York, New York); Ruth Dannenfelser (Princeton, New Jersey) |
| ABSTRACT | The present disclosure provides immune cells genetically modified to produce two antigentriggered polypeptides, each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. The present disclosure further provides systems comprising two antigen-triggered polypeptides (or nucleic acids encoding same), each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. Also provided are method of killing a target cancer cell, using the described genetically modified immune cells and/or systems. The present disclosure also provides poly specific-immune inducing polypeptides including first and second antigen binding domains specific for first and second antigens, respectively, present on the surface of a target cancer cell. |
| FILED | Thursday, November 07, 2019 |
| APPL NO | 17/291794 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/28 (20130101) C07K 16/40 (20130101) C07K 16/3015 (20130101) Original (OR) Class C07K 2317/31 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127569 | Pena et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rafael Gras Pena (New York, New York); Megan Sykes (New York, New York); Nichole Danzi (New York, New York); Mohsen Khosravi-Maharlooei (New York, New York) |
| ABSTRACT | The current disclosure provides for methods of promoting differentiation of pluripotent stem cells into thymic epithelial cells or thymic epithelial cell progenitors as well as the cells obtained from the methods, and solutions, compositions, and pharmaceutical compositions comprising such cells. The current disclosure also provides for methods of using the thymic epithelial cells or thymic epithelial cell progenitors for treatment and prevention of disease, generating organs, as well as other uses, and kits. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/492137 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/26 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0634 (20130101) Original (OR) Class C12N 2501/15 (20130101) C12N 2501/16 (20130101) C12N 2501/41 (20130101) C12N 2501/115 (20130101) C12N 2501/155 (20130101) C12N 2506/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127575 | Kaplan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | Rosandra N. Kaplan (Potomac, Maryland); Sabina A. Kratzmeier (North Bethesda, Maryland); Daniel W. Beury (Laurel, Maryland); Haiying Qin (Potomac, Maryland) |
| ABSTRACT | Provided are compositions comprising genetically modified hematopoietic stem and progenitor cells (HSPCs) and/or genetically modified mesenchymal cells, wherein the cells contain a vector comprising a transgene, as well as methods of producing the genetically modified HSPCs and genetically modified mesenchymal cells, and methods of treating or preventing cancer (e.g., metastasis) and neurodegenerative conditions, autoimmune disorders, and inflammatory disorders. |
| FILED | Monday, February 10, 2020 |
| APPL NO | 17/429391 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 5/0663 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127577 | Hematti et al. |
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| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peiman Hematti (Middleton, Wisconsin); Jaehyup Kim (Madison, Wisconsin) |
| ABSTRACT | The invention relates to purified, tissue-specific progenitors, methods of making and using such tissue-specific progenitors. |
| FILED | Wednesday, October 06, 2021 |
| APPL NO | 17/495411 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) A61K 2035/124 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0647 (20130101) Original (OR) Class C12N 5/0676 (20130101) C12N 5/0693 (20130101) C12N 5/0694 (20130101) C12N 2502/1157 (20130101) C12N 2502/1358 (20130101) C12N 2506/02 (20130101) C12N 2506/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127579 | HEMATTI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peiman HEMATTI (Madison, Wisconsin); John KINK (Madison, Wisconsin); Christian CAPITINI (Madison, Wisconsin); Matthew FORSBERG (Stoughton, Wisconsin); Nicholas HESS (Cottage Grove, Wisconsin); Zachary ROSENKRANS (Madison, Wisconsin); Reinier HERNANDEZ (Madison, Wisconsin) |
| ABSTRACT | The disclosure relates to populations of educated macrophages and monocytes generated ex vivo or in vivo, and methods of making and using the same using lipid A aminoalkylglucosaminide phosphate molecules, such as CRX molecules or extracellular vesicles (EVs) from mesenchymal stromal cells (MSC) stimulated with CRX molecules. Also described are EVs and methods for making and using the same from MSCs exposed to CRX. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508855 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/15 (20130101) A61K 35/35 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0645 (20130101) C12N 5/0668 (20130101) Original (OR) Class C12N 2500/84 (20130101) C12N 2502/1323 (20130101) C12N 2502/1358 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127581 | Tsai et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Li-Huei Tsai (Cambridge, Massachusetts); Joel Blanchard (Arlington, Massachusetts); Alice Stanton (Boston, Massachusetts); Adele Bubnys (Cambridge, Massachusetts); Robert S. Langer (Newton, Massachusetts) |
| ABSTRACT | The present disclosure provides, in some embodiments, in vitro brain (miBRAIN) having functional and structural properties of in vivo brain as well as methods of identifying compounds capable of influencing brain function. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458838 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0062 (20130101) C12N 5/0607 (20130101) C12N 5/0622 (20130101) C12N 5/0691 (20130101) Original (OR) Class C12N 2502/28 (20130101) C12N 2503/00 (20130101) C12N 2513/00 (20130101) C12N 2533/90 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127585 | MCINNES et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF SOUTH CAROLINA (Columbia, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CAMPBELL MCINNES (IRMO, South Carolina); CHAD BENEKER (COLUMBIA, South Carolina) |
| ABSTRACT | Inhibitory peptides for modifying RAF kinase protein dimerization are described. The peptides display a binding affinity for the dimer interface of a B-Raf, allowing for modification of RAF kinase dimerization, and inhibition of tumor growth. An embodiment of the disclosure is a peptide generated by modifying SEQ ID NO: 1, which corresponds to amino acids 503-521 of B-Raf kinase, e.g., cyclization, N-terminal capping, C-terminal capping, substitution of one or more amino acid residues, etc. The peptides disclosed herein include a modification to SEQ ID NO: 1 that can improve or otherwise alter binding affinity of the peptide to the dimer interface. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/409306 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/45 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) Original (OR) Class Enzymes C12Y 207/11001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127586 | Whiteley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); President And Fellows Of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Whiteley (Brookline, Massachusetts); Philip J. Kranzusch (Brighton, Massachusetts); John Mekalanos (Newton, Massachusetts); James Eaglesham (Boston, Massachusetts) |
| ABSTRACT | The present invention is based, in part, on the discovery and characterization of the CD-NTase family of proteins, as well as compositions comprising CD-NTases, methods of producing nucleotide-based second messengers using such polypeptides, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides. |
| FILED | Wednesday, September 04, 2019 |
| APPL NO | 17/270234 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/1241 (20130101) Original (OR) Class C12N 11/06 (20130101) C12N 15/10 (20130101) C12N 15/70 (20130101) C12N 15/1137 (20130101) C12N 15/8509 (20130101) C12N 2015/8527 (20130101) C12N 2310/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/5023 (20130101) G01N 2333/91245 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127590 | Fischetti et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vincent A. Fischetti (New York, New York); Jonathan Schmitz (New York, New York); Daniel Gilmer (New York, New York); Chad Euler (New York, New York) |
| ABSTRACT | The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/465931 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/47 (20130101) A61K 38/50 (20130101) A61K 38/162 (20130101) A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/2462 (20130101) Original (OR) Class Enzymes C12Y 302/01017 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127607 | Flanigan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio); UNIVERSITY OF WESTERN AUSTRALIA (Crawley, Australia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Flanigan (Columbus, Ohio); Nicolas Sebastien Wein (Columbus, Ohio); Stephen Wilton (Perth, Australia) |
| ABSTRACT | The present invention relates to the delivery of oligomers for treating patients with a 5′ mutation in their DMD gene other than a DMD exon 2 duplication. The invention provides methods and materials for activating an internal ribosome entry site in exon 5 of the DMD gene resulting in translation of a functional truncated isoform of dystrophin. The methods and materials can be used for the treatment of muscular dystrophies arising from 5′ mutations in the DMD gene such as Duchenne Muscular Dystrophy or Becker Muscular Dystrophy. |
| FILED | Tuesday, June 01, 2021 |
| APPL NO | 17/335251 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/58 (20130101) A61K 31/573 (20130101) A61K 31/712 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/315 (20130101) C12N 2310/346 (20130101) C12N 2310/3231 (20130101) C12N 2310/3233 (20130101) C12N 2310/3513 (20130101) C12N 2310/3519 (20130101) C12N 2320/31 (20130101) C12N 2320/33 (20130101) C12N 2330/51 (20130101) C12N 2750/14143 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127621 | Yeo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eugene Yeo (La Jolla, California); Frederick Tan (Encinitas, California) |
| ABSTRACT | Described herein are compositions, systems, methods, and kits utilizing RNA binding protein fusions, such as CRISPR-Cas protein fusions comprising a guide nucleotide sequence-programmable RNA binding protein, and a translation modifier protein. Also, described herein are compositions, systems, methods, and kits utilizing CRISPR-Cas associated RNA fusions comprising a guide nucleotide sequence-programmable RNA and an internal ribosome entry site (IRES). The compositions, systems, methods, and kits described herein are useful to upregulate or downregulate mRNA translation. |
| FILED | Monday, April 22, 2019 |
| APPL NO | 17/049198 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/62 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2310/3519 (20130101) C12N 2800/80 (20130101) C12N 2840/203 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127670 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jan Biotech, Inc. (Ithaca, New York) |
| ASSIGNEE(S) | Jan Biotech, Inc. (Ithaca, New York) |
| INVENTOR(S) | Can Zhou (Ithaca, New York); Janet Lockwood Huie (Ithaca, New York); Jennifer Anastasia Nichols (Ithaca, New York) |
| ABSTRACT | This application describes a fluorogenic nucleic acid kit or composition for quantitative detection of a target ribonucleic acid (RNA) sequence in a test sample comprising at least one pair of oligonucleotide probes comprising a photocatalyst probe and a profluorophore probe, wherein one of the photocatalyst probe and the profluorophore probe is complementary to and capable of specifically binding an upstream portion of the target RNA sequence, and the other probe is complementary to and capable of specifically binding to a downstream portion of the target RNA sequence, the photocatalyst probe comprises a first oligonucleotide covalently bound to a photocatalyst, the profluorophore probe comprises a second oligonucleotide covalently bound to a profluorophore, and the photocatalyst is activatable by exposure to light and a reducing agent to form a reduced, activated photocatalyst that, when both probes of the pair are hybridized to the target RNA sequence, is capable of photoreducing the profluorophore to form a detectable fluorophore. The application also describes methods for quantitative detection of target RNA. |
| FILED | Tuesday, March 23, 2021 |
| APPL NO | 17/209381 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/703 (20130101) C12Q 1/6816 (20130101) C12Q 1/6876 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127673 | Khatri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Purvesh Khatri (Menlo Park, California); Timothy E. Sweeney (Redwood City, California) |
| ABSTRACT | Methods for diagnosis of bacterial and viral infections are disclosed. In particular, the invention relates to the use of biomarkers that can determine whether a patient with acute inflammation has a bacterial or viral infection. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/570315 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/701 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127676 | Moffitt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Richard Moffitt (Stony Brook, New York); Jen Jen Yeh (Chapel Hill, North Carolina); Naim Ur Rashid (Chapel Hill, North Carolina) |
| ABSTRACT | Methods for generating a prognostic and/or subtype signature for a subject with pancreatic ductal adenocarcinoma (PDAC) are provided. In some embodiments, the methods include determining expression levels for one or more genes listed in Tables 2-5, 9, 10, or 11, and/or the DE-S and/or DE-T subset of genes in PDAC cells obtained from the subject, wherein the determining provides a prognostic and/or subtype signature for the subject. Also provided are methods for classifying a subject diagnosed with pancreatic ductal adenocarcinoma (PDAC) as having an activated stroma subtype or a normal stroma subtype of PDAC and/or a basal subtype or a classical subtype of PDAC; and methods for identifying a differential treatment strategy for a subject diagnosed with pancreatic ductal adenocarcinoma (PDAC). |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336600 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/118 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) G01N 2800/52 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 25/00 (20190201) G16B 25/10 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127682 | Yaffe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts); Cardiff Oncology, Inc. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael B. Yaffe (Cambridge, Massachusetts); Jesse C. Patterson (Cambridge, Massachusetts); Mark Erlander (San Diego, California); Peter J.P. Croucher (San Diego, California); Maya Ridinger (San Diego, California) |
| ABSTRACT | Certain molecular characteristics of cancer cells or tumors can be indicative of their sensitivity to various combination therapies. The cancer cells or tumors exhibiting such molecular profiles, such as upregulation of genes associated with mitosis or meiosis, can be sensitive to additive and more than additive effects of combination therapies. Methods for identifying, selecting, and/or treating cancer patients whose cancer is amenable to combination therapies including an antiandrogen or androgen antagonist in combination with a Plk inhibitor are disclosed. Administration of the combination of the active agents can reduce cancer cell proliferation or viability and/or tumor burden in a subject with cancer to the same degree, or a greater degree than administering to the subject the same amount of either active agent alone. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/459477 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128346 | Lipson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michal Lipson (New York, New York); Xingchen Ji (New York, New York); Alexander Klenner (New York, New York); Xinwen Yao (Baltimore, Maryland); Yu Gan (Harriston, New Jersey); Alexander L. Gaeta (New York, New York); Christine P Hendon (Bronx, New York) |
| ABSTRACT | A method of providing optical coherence tomography (OCT) imaging may comprise using an on-chip frequency comb source interfaced with an OCT system by a circulator as an imaging source and reconstructing OCT images from resulting spectral data from target tissue illuminated by the imaging source. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/367884 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02008 (20130101) Original (OR) Class G01B 9/02091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128445 | Hering et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| ASSIGNEE(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| INVENTOR(S) | Susanne Vera Hering (Berkeley, California); Gregory Stephen Lewis (Berkeley, California); Steven Russel Spielman (Oakland, California) |
| ABSTRACT | A method and apparatus to create water vapor supersaturation and particulate counts from an air sample. The method and apparatus include introducing an air sample into a chamber connected to an optical detector and an outlet by pumping at the outlet. The method further includes passing air through the chamber and optical detector in a steady flow, and subsequently closing the inlet while continuing the pumping to expand the air sample and exhaust a portion of the air sample through the optical detector. The walls of the particle chamber are wetted with a fluid such as water, and one portion of the wall is warmer than the other portions such that there is some condensational growth prior to the expansion, and yet more condensational growth during the expansion. The cycles are repeated by continuously repeating the introducing, passing and closing. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/568940 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/06 (20130101) Original (OR) Class G01N 2015/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128547 | Wiktor et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Ariz (Scottsdale, Arizona); Engineering Arts LLC (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Wiktor (Phoenix, Arizona); Joshua Labaer (Chandler, Arizona); Peter Kahn (Phoenix, Arizona); Bharath Takulapalli (Tempe, Arizona); Ji Qiu (Chandler, Arizona); Al Brunner (Phoenix, Arizona); Mitch Magee (Chandler, Arizona) |
| ABSTRACT | Biomolecule arrays on a substrate are described which contain a plurality of biomolecules, such as coding nucleic acids and/or isolated polypeptides, at a plurality of discrete, isolated, locations. The arrays can be used, for example, in high throughput genomics and proteomics for specific uses including, but not limited molecular diagnostics for early detection, diagnosis, treatment, prognosis, monitoring clinical response, and protein crystallography. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/337274 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) B01J 2219/00317 (20130101) B01J 2219/00596 (20130101) B01J 2219/00608 (20130101) B01J 2219/00612 (20130101) B01J 2219/00621 (20130101) B01J 2219/00626 (20130101) B01J 2219/00637 (20130101) B01J 2219/00659 (20130101) B01J 2219/00722 (20130101) B01J 2219/00725 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1079 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 50/14 (20130101) C40B 60/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/543 (20130101) Original (OR) Class G01N 33/6845 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128571 | Bhatia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Sangeeta N. Bhatia (Lexington, Massachusetts); Geoffrey A. von Maltzahn (Boston, Massachusetts); Gabriel A. Kwong (Atlanta, Georgia) |
| ABSTRACT | The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570847 |
| CURRENT CPC | Peptides C07K 7/06 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) C12Q 1/56 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6842 (20130101) G01N 33/6848 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128675 | Fatemi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mostafa Fatemi (Rochester, Minnesota); Bae H. Kim (London, United Kingdom); Azra Alizad (Rochester, Minnesota) |
| ABSTRACT | Systems and methods are provided for suppressing the side-lobe artifacts in ultrasound imaging with plane wave compounding. The use of discrete angles in transmitting plane waves may be used to suppress side-lobes and the resulting side-lobe artifacts without increasing the number of firings required. A method is provided that utilizes nulls in Rx beam pattern to suppress side-lobes based on the beam pattern formula. An apodization technique that uses window functions according to Tx angles and/or Rx aperture may also be used. A method using aperiodic sampling angles may also be used to suppress artifacts. Application to arbitrary interval sampling angles may be found. Suppressing artifacts according to the present disclosure may provide for wider field of view imaging without resorting to increasing the number of firings required (NFR). |
| FILED | Monday, February 03, 2020 |
| APPL NO | 17/427822 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/5269 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/52047 (20130101) Original (OR) Class G01S 15/8915 (20130101) G01S 15/8997 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129071 | Pandarinath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chethan Pandarinath (Decatur, Georgia); Mohammadreza Keshtkaran (Atlanta, Georgia); Yahia Hassan Ali (Atlanta, Georgia); Lahiru Neth Wimalasena (Atlanta, Georgia); Andrew Robert Sedler (Atlanta, Georgia); Lee Eugene Miller (Chicago, Illinois); Josephine Jane Wallner (Chicago, Illinois); Xuan Ma (Chicago, Illinois); Ali Farshchian (Chicago, Illinois); Brianna Marie Karpowicz (Atlanta, Georgia) |
| ABSTRACT | The disclosures relates to systems and methods for using a trained alignment neural network along with a trained latent representation model to achieve accurate alignment between complex neural signals arising from co-variation across neuron populations over time and their intended motor control that can be invariant for a much longer period without supervised recalibrations. In one implementation, the method may include receiving neural data for a period of time from one or more sensors. The method may further include transforming the neural data to generate aligned variables using a trained alignment network. The method may also include processing the aligned variables through a trained latent model to determine a latent spatiotemporal representation of one or more brain state variables for the period of time and decoding the latent spatiotemporal representation into a brain state for the period of time. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512339 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/015 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129930 | Cranshaw et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin Cranshaw (Pittsburgh, Pennsylvania); Raz Schwartz (New York, New York); Jason I. Hong (Pittsburgh, Pennsylvania); Norman Sadeh-Koniecpol (Pittsburgh, Pennsylvania) |
| ABSTRACT | Computer-based systems and methods for discovering neighborhood clusters in a geographic region, where the clusters have a mix of venues and are determined based on venue check-in data. The mix of venues for the clusters may be based on the social similarity between pairs of venues; or emblematic of certain neighborhood typologies; or emblematic of temporal check-in pattern types; or combinations thereof. The neighborhood clusters that are so discovered through venue-check in data could be used for many commercial and civic purposes. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/572252 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0205 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220130654 | WYSOCKI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vicki WYSOCKI (Columbus, Ohio); Dalton SNYDER (Columbus, Ohio); Benjamin JONES (Columbus, Ohio); Alyssa STIVING (Columbus, Ohio); Joshua GILBERT (Columbus, Ohio); Zachary VANAERNUM (Columbus, Ohio); Sophie HARVEY-BERNIER (Columbus, Ohio) |
| ABSTRACT | Devices and methods for surface-induced association are disclosed herein. According to one embodiment, a device for surface-induced dissociation (SID) includes a collision surface and a deflector configured to guide precursor ions from a pre-SID region to the collision surface. In some embodiments, an extractor extracts ions off the collision surface after collision with the collision surface. In some embodiments, an RF device can collect and/or transmit the extracted ions. In some embodiments, an ion funnel guides product ions resulting from collision with the collision surface to a post-SID region. Some aspects of the disclosure are directed to methods for surface-induced dissociation, which may in some embodiments include using of a split lens or an ion funnel. |
| FILED | Sunday, December 15, 2019 |
| APPL NO | 17/431299 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 49/066 (20130101) H01J 49/0068 (20130101) Original (OR) Class H01J 49/4225 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220125369 | McGinley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Baylor College of Medicine (Houston, Texas); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Matthew McGinley (Houston, Texas); Justin Williams (Cambridge, Wisconsin); Aaron Suminski (McFarland, Wisconsin) |
| ABSTRACT | One aspect of the invention provides a method of measuring brain state. The method includes: receiving a first plurality of electrical signals from a contact lens placed on a surface of a subject's eye, the first plurality of electrical signals associated with a first plurality of electrodes lying adjacent to an iris dilator muscle of the subject's eye. Another aspect of the invention provides a contact lens including: an optically transparent or translucent substrate; and one or more pairs of electromyography electrodes arranged on or within the optically transparent or translucent substrate. At least one of the one or more pairs electromyography electrodes are arranged to lie adjacent to an iris dilator muscle of a subject's eye when the contact lens is placed on the eye. |
| FILED | Wednesday, February 26, 2020 |
| APPL NO | 17/427180 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0002 (20130101) A61B 5/296 (20210101) A61B 5/389 (20210101) A61B 5/4064 (20130101) Original (OR) Class A61B 5/6821 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125375 | Reifman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Ft. Detrick, Maryland) |
| ASSIGNEE(S) | The Government of the United States, as represented by the Secretary of the Army (Ft. Detrick, Maryland) |
| INVENTOR(S) | Jaques Reifman (New Market, Maryland); Jianbo Liu (Lexington, Virginia); Nancy Wesensten (Silver Spring, Maryland); Thomas Balkin (Ellicott City, Maryland); Sridhar Ramakrishnan (Frederick, Maryland); Maxim Y. Khitrov (Rockville, Maryland) |
| ABSTRACT | A system, method and apparatus is disclosed, comprising a biomathetical model for optimizing cognitive performance in the face of sleep deprivation that integrates novel and nonobvious biomathematical models for quantifying performance impairment for both chronic sleep restriction and total sleep deprivation; the dose-dependent effects of caffeine on human vigilance; and the pheonotypical response of a particular user to caffeine dosing, chronic sleep restriction and total sleep deprivation in user-friendly software application which itself may be part of a networked system. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573475 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/00 (20130101) A61B 5/02 (20130101) A61B 5/11 (20130101) A61B 5/18 (20130101) A61B 5/103 (20130101) A61B 5/113 (20130101) A61B 5/162 (20130101) A61B 5/165 (20130101) A61B 5/0255 (20130101) A61B 5/486 (20130101) Original (OR) Class A61B 5/1118 (20130101) A61B 5/4806 (20130101) A61B 5/4839 (20130101) A61B 5/4857 (20130101) A61B 5/6898 (20130101) A61B 5/7225 (20130101) A61B 5/7275 (20130101) A61B 5/7435 (20130101) A61B 5/7475 (20130101) A61B 2503/20 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 15/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125386 | Marras et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William S. Marras (Powell, Ohio); Jonathan Dufour (Columbus, Ohio); Alexander Aurand (Columbus, Ohio); Prasath Mageswaran (Columbus, Ohio); Gregory Knapik (Columbus, Ohio) |
| ABSTRACT | An integrated and holistic system that delivers clinical decision support, disorder prevention, and research services for chronic disorders is provided. In one embodiment, the system collects a variety of data about an individual including data from one or more of wearable motion sensors, self-reported questionnaires, medical imaging, and electronic medical records. A historical database of outcomes and similar data for other individuals is processed using advanced statistics, artificial intelligence, and machine learning to identify biomarkers and phenotypes that are indicative of outcomes with respect to zero or more interventions. The collected individual's data is then analyzed with respect to the identified biomarkers or phenotypes to predict outcomes with respect to zero or more interventions for the individual. The individual, and/or an associated agent, may then consider the predicted outcomes when selecting an intervention plan for the individual and monitor intervention impact over time. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/458756 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/1116 (20130101) A61B 5/7275 (20130101) Original (OR) Class A61B 2503/24 (20130101) A61B 2562/0219 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/20 (20180101) G16H 10/60 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125388 | BULLER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States, as Represented by the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark Jonathan BULLER (Douglas, Massachusetts); David Patrick LOONEY (Framingham, Massachusetts) |
| ABSTRACT | The invention in at least one embodiment includes a method for determining the core body temperature of a person by determining an initial core body temperature and heart rate of said person; providing the initial core body temperature and heart rate of the person to a processor; and calculating a predicted core body temperature by the processor using an extended Kalman filter based on the heart rate and the initial core body temperature. In another embodiment, a system for performing the method. |
| FILED | Friday, February 07, 2020 |
| APPL NO | 17/428525 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0008 (20130101) A61B 5/024 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/02055 (20130101) A61B 5/7225 (20130101) A61B 5/7275 (20130101) A61B 5/7278 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125437 | Burkhart et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Joseph Thomas Burkhart (Bloomfield, Indiana); Danielle E. Cafasso (Southern Pines, North Carolina); Robert Henry Hayford (Colorado Springs, Colorado); Huckelberry Finne (Norfolk, Virginia); Jose Ramirez Vargas (Clovis, New Mexico); Michael P Abbott (Chesapeake, Virginia) |
| ABSTRACT | A junctional tourniquet apparatus and related methods of use. An exemplary tourniquet has an inverted cone shape, wherein a narrower end has a mushroom shaped base that is pressed against a compression target and a broader end has a plurality of pass-through slots for straps. Another exemplary tourniquet has a broad plate component and a handle component. The handle component has a mushroom shaped base on a first end and a handle on a second end. The handle component passes through the center of the plate component with threads that allow the handle component to compress a target by twisting the handle. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570680 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/1325 (20130101) Original (OR) Class A61B 17/1327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125779 | Carver |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, the University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chase Carver (San Antonio, Texas) |
| ABSTRACT | Certain embodiments are directed to methods and compositions for treating or preventing seizures in a subject using a therapeutic agent comprising one or more Transient Receptor Potential-Canonical 4/5 channel antagonists sufficient to regulate excitability of neurons in the brain of a subject. |
| FILED | Thursday, February 25, 2021 |
| APPL NO | 17/185031 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4184 (20130101) A61K 31/4709 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125842 | O'Malley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/446282 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125930 | Kaplan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Trustees of Tufts College (Medford, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David L. Kaplan (Concord, Massachusetts); Ilia A. Rodionov (Medford, Massachusetts) |
| ABSTRACT | A method of making drug-eluting regenerated silk fibroin particles using cryogranulation. The method has a first step of injecting a mixture into a super-cooled fluid, the mixture including regenerated silk fibroin and at least one medicament. A second step of incubating the drug-eluting particles in the super-cooled fluid to promote cryogelation may also be used. The size distribution, morphology, and cross-linking efficiency of the particles can depend on several controllable variable, such as starting concentrations of cross-linking agents and silk fibroin in the mixture, the injection pressure, and the temperature of the super-cooled fluid. |
| FILED | Wednesday, February 12, 2020 |
| APPL NO | 17/310586 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/4825 (20130101) A61K 9/4833 (20130101) A61K 45/06 (20130101) A61K 47/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126045 | Dory et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America as Represented by the Secretary of the Navy (Silver Spring, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roy Dory (San Antonio, Texas); Justin P Bequette (San Antonio, Texas); Molly Marbut (Cibolo, Texas) |
| ABSTRACT | An endotracheal tube stabilization device comprising an endotracheal tube holder with an elongated generally tubular body and a bite block, a removable rotating wing plate on said endotracheal tube holder, and a strap assembly. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513082 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/0497 (20130101) Original (OR) Class A61M 2205/0238 (20130101) A61M 2209/088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126257 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ruixuan Gao (Cambridge, Massachusetts); Ishan Gupta (Cambridge, Massachusetts); Edward S. Boyden (Chestnut Hill, Massachusetts) |
| ABSTRACT | A method for synthesizing nanoparticles by sonofragmentation includes dispersing ultra-thin substrate units in a solvent chosen for suitability for sonofragmentation of the substrate, forming a suspension; ultrasonicating the suspension for a length of time sufficient to fragment the substrate into nanoparticles that are dispersed in the solvent; and evaporating the solvent. Solvent exchange with a second solvent may be performed. The synthesized nanoparticles are highly crystalline and monodispersed. The surface of the synthesized nanoparticles may be functionalized by choosing the solvents according to chemistry related to the intended surface functionalization of the synthesized nanoparticles, by adding surfactants to one or more of the solvents, and/or by performing ligand exchange or chemical modification to replace surface-bonded solvent or surfactant molecules with other functional groups to produce nanoparticles having the desired surface functionalization. |
| FILED | Wednesday, September 01, 2021 |
| APPL NO | 17/464651 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/10 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126268 | Weston et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | NuMat Technologies Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | NuMat Technologies Inc. (Skokie, Illinois) |
| INVENTOR(S) | Mitchell Hugh Weston (Chicago, Illinois); Edwin Alfonso Argueta Fajardo (Chicago, Illinois) |
| ABSTRACT | This invention relates to a Cu-BTC MOF which is water stable. The Cu-BTC MOF has been modified by substituting some of the BTC ligand (1,3,5, benzene tricarboxylic acid) with 5-aminoisophthalic acid (AIA). The resultant MOF retains at least 40% of its as synthesized surface area after exposure to liquid water at 60° C. for 6 hours. This is an unexpected result versus the MOF containing only the BTC ligand. This MOF can be used to abate contaminants such as ammonia in gas streams and especially air streams. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571073 |
| CURRENT CPC | Separation B01D 53/58 (20130101) B01D 53/82 (20130101) B01D 53/8634 (20130101) B01D 2253/204 (20130101) B01D 2255/705 (20130101) B01D 2255/9207 (20130101) B01D 2257/406 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/3085 (20130101) B01J 20/28016 (20130101) B01J 20/28019 (20130101) B01J 20/28038 (20130101) B01J 20/28045 (20130101) B01J 20/28066 (20130101) B01J 20/28073 (20130101) B01J 31/1691 (20130101) B01J 35/04 (20130101) B01J 35/08 (20130101) B01J 35/026 (20130101) B01J 35/1028 (20130101) B01J 37/04 (20130101) B01J 37/10 (20130101) B01J 2231/005 (20130101) B01J 2531/16 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126370 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Jian Liu (Cary, North Carolina); Shuang Bai (Cary, North Carolina) |
| ASSIGNEE(S) | PolarOnyx, Inc. (Chapel Hill, North Carolina) |
| INVENTOR(S) | Jian Liu (Cary, North Carolina); Shuang Bai (Cary, North Carolina) |
| ABSTRACT | Methods and apparatuses for AM of all-in-one radiation shielding components from multi-material metal alloys, metal matrix, MMCs, and/or gradated compositions of the same are disclosed, comprising: providing an apparatus having: an energy source; a scanner; a powder system for powder(s); a powder delivery system; a shielding gas; and a computer coupled to and configured to control the energy source, scanner, powder system, and powder delivery system to deposit layers of the sample; programming the computer with specifications of the sample; using the computer to control electromagnetic radiation, mixing ratio, and powder deposition parameters based on the specifications of the sample; and using the autofocusing scanner to focus and scan the electromagnetic radiation onto the sample while the powders are concurrently deposited by the powder delivery system onto the sample to create a melting pool to deposit one or more layers onto the sample. Other embodiments are described and claimed. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511073 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/062 (20220101) B22F 1/065 (20220101) B22F 1/068 (20220101) B22F 10/36 (20210101) Original (OR) Class B22F 10/85 (20210101) B22F 12/30 (20210101) B22F 12/49 (20210101) B22F 12/58 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126961 | Bergsrud et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America, as represented by the Secretary of the Navy (Crane, Indiana) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| INVENTOR(S) | Corey Bergsrud (Bloomington, Indiana); Katherine Grace Pfeiffer (Bloomington, Indiana); Edward Zipperle (Washington, Indiana); Michael Combs (Bloomfield, Indiana) |
| ABSTRACT | Provided is a radar and communications enhanced sail for a sailboat, sail ship, or sail drone. The sail includes a first sail section comprising an active communication system, a second sail section comprising a passive communication system, or a combination thereof. The active communication system includes an antenna array (transceiver) and a software-defined radio (SDR), while the passive communication system comprises a reflective panel or sections and/or array of reflector panels or sections. The active system utilizes its SDR and transceiver to communicate back and forth with an onshore SDR and transceiver to provide information as necessary. The passive system receives a radar signal via the reflective material on the sail and reflects the signal back at the radar, which produces a radar cross section indicating that there is an object (in this case the sailboat) in the ocean. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/507031 |
| CURRENT CPC | Marine Propulsion or Steering B63H 9/067 (20200201) Original (OR) Class Antennas, i.e Radio Aerials H01Q 15/14 (20130101) H01Q 21/00 (20130101) Transmission H04B 1/0003 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126992 | Shundo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bell Textron Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ken Shundo (Keller, Texas); Bryan Baskin (Arlington, Texas) |
| ABSTRACT | In one embodiment of the present disclosure, there is provided a drive tube and swashplate trunnion assembly. The drive tube and swashplate trunnion assembly includes a drive tube having a plurality of grooves formed on an outer surface of the drive tube; a swashplate trunnion having a plurality of grooves formed on an inner surface of the swashplate trunnion, wherein individual grooves of the plurality of grooves on the swashplate trunnion mate with individual grooves of the plurality of grooves on the drive tube to form a plurality of channels; and a plurality of cylindrical bearings, wherein each of said cylindrical bearings is disposed within an individual channel of the plurality of channels. |
| FILED | Tuesday, October 27, 2020 |
| APPL NO | 17/081423 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/605 (20130101) Original (OR) Class Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 35/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126993 | Haldeman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bell Textron Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Paul Haldeman (Fort Worth, Texas); Paul Wayne Woolbright (Euless, Texas); Bryan Baskin (Arlington, Texas) |
| ABSTRACT | A rotor assembly includes a pitch spider, rotor blade assemblies, and pitch horn joints. The pitch spider has a body and pitch spider legs extending from the body. Each blade rotor assembly includes a rotor blade, a pitch adapter joined to the rotor blade and connecting the rotor blade to the rotor hub, and a pitch horn. Each pitch horn joint joins one of the rotor blade assemblies to a corresponding pitch spider leg. Each pitch horn joint includes a pitch horn joint bolt extending from the pitch horn of the rotor blade assembly to the pitch spider leg along a pitch horn joint axis, the pitch horn joint bolt fixed to the pitch horn; a spherical bearing having an inner ring and an outer ring; and a slider sleeve coupled to the spherical bearing, the slider sleeve enabling the pitch horn to translate along the pitch horn joint axis. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/082659 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 27/82 (20130101) B64C 27/605 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127198 | WEIMER et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ALAN WEIMER (Niwot, Colorado); BOLA YOON (Boulder, Colorado); RISHI RAJ (Boulder, Colorado); REBECCA O'TOOLE (Boulder, Colorado) |
| ABSTRACT | Methods of flash sintering have been developed in which particle are initially coated with thin layers by atomic layer deposition (ALD). Examples are provided in which 8 mol % yttria-stabilized zirconia (8YSZ) particles are coated with small quantities of Al2O3 by particle atomic layer deposition (ALD). Sintered materials that result from the process have been characterized. Sintered materials having unique characteristics are also described. |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 17/434719 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/117 (20130101) C04B 35/563 (20130101) C04B 35/565 (20130101) C04B 35/581 (20130101) C04B 35/4885 (20130101) C04B 35/6281 (20130101) C04B 35/62813 (20130101) C04B 35/62815 (20130101) C04B 35/62836 (20130101) C04B 35/62884 (20130101) Original (OR) Class C04B 35/62889 (20130101) C04B 35/62894 (20130101) C04B 35/62897 (20130101) C04B 2235/66 (20130101) C04B 2235/785 (20130101) C04B 2235/786 (20130101) C04B 2235/3206 (20130101) C04B 2235/3208 (20130101) C04B 2235/3217 (20130101) C04B 2235/3225 (20130101) C04B 2235/3246 (20130101) C04B 2235/3821 (20130101) C04B 2235/3826 (20130101) C04B 2235/3865 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/56 (20130101) C23C 16/403 (20130101) C23C 16/4417 (20130101) C23C 16/45555 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1253 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127421 | Brennan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (GAINESVILLE, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anthony B. Brennan (Gainesville, Florida); Vishal Vignesh (Gainesville, Florida) |
| ABSTRACT | Disclosed herein is a composition comprising a water soluble monomer or polymer; a fluorine functionalized acrylate; and a non-isocyanate urethane acrylate. Disclosed herein is a method comprising mixing a water soluble monomer or polymer, a fluorine functionalized acrylate and a non-isocyanate urethane acrylate to form a composition; and curing the composition. |
| FILED | Thursday, March 05, 2020 |
| APPL NO | 17/434512 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 220/22 (20130101) C08F 220/56 (20130101) C08F 222/1065 (20200201) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 71/04 (20130101) Original (OR) Class C08G 2210/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 175/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128341 | Jones et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jaylan Jones (Tucson, Arizona); Donald Messitt (Folsom, California); Brian Hodge (Tucson, Arizona); Gabe Harris (Tucson, Arizona) |
| ABSTRACT | An integrated propulsion and warhead system for an artillery round includes a propulsion, such as a solid rocket motor and/or an air-breathing jet engine, and an annular explosive concentrically arranged around at least a portion of the propulsion system. The integrated propulsion and warhead system is included in a propulsion section of the artillery round so that space in an adjacent guidance section is increased and the space allocation for the propulsion system and annular explosive is optimized. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/080097 |
| CURRENT CPC | Jet-propulsion Plants F02K 7/18 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 10/40 (20130101) Original (OR) Class F42B 12/207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128346 | Lipson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michal Lipson (New York, New York); Xingchen Ji (New York, New York); Alexander Klenner (New York, New York); Xinwen Yao (Baltimore, Maryland); Yu Gan (Harriston, New Jersey); Alexander L. Gaeta (New York, New York); Christine P Hendon (Bronx, New York) |
| ABSTRACT | A method of providing optical coherence tomography (OCT) imaging may comprise using an on-chip frequency comb source interfaced with an OCT system by a circulator as an imaging source and reconstructing OCT images from resulting spectral data from target tissue illuminated by the imaging source. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/367884 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02008 (20130101) Original (OR) Class G01B 9/02091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128551 | Shih et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wan Y. Shih (Bryn Mawr, Pennsylvania); Wei Wu (Philadelphia, Pennsylvania); Wei-Heng Shih (Bryn Mawr, Pennsylvania); Mehmet Cagri Soylu (Melikgazi (Kayseri), Turkey); Haitao Guo (Carmel, Indiana); Suresh G. Joshi (Secane, Pennsylvania); Ceyhun Ekrim Kirimli (Thunder Bay, Canada); Ying-Hsiu Su (Audubon, Pennsylvania) |
| ASSIGNEE(S) | Drexel University (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Wan Y. Shih (Bryn Mawr, Pennsylvania); Wei Wu (Philadelphia, Pennsylvania); Wei-Heng Shih (Bryn Mawr, Pennsylvania); Mehmet Cagri Soylu (Melikgazi (Kayseri), Turkey); Haitao Guo (Carmel, Indiana); Suresh G. Joshi (Secane, Pennsylvania); Ceyhun Ekrim Kirimli (Thunder Bay, Canada); Ying-Hsiu Su (Audubon, Pennsylvania) |
| ABSTRACT | A piezoelectric plate sensor comprising a piezoelectric layer; two electrodes; and an insulation layer. The insulation layer is produced by soaking the piezoelectric layer and two electrodes in a mercaptopropyltrimethoxysilane solution with an amount of water from 0.1 v/v. % to about 1 v/v % and at pH from about 8 to about 150 for a period from about 8 to about 15 hours, and the mercaptopropyltrimethoxysilane solution has a concentration of mercaptopropyltrimethoxysilane from about 0.01 v/v % to about 0.5 v/v %. A method of detecting a biomolecule in a sample using the piezoelectric plate sensor in particular, that of detecting a genetic marker with PCR sensitivity and specificity without the need of DNA isolation or amplification is also provided. The piezoelectric plate sensor may be used to diagnose various diseases including breast cancer, myocardial infarction, diarrhea, Clostridium difficile infection, and hepatitis B infection. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/567992 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/022 (20130101) G01N 29/036 (20130101) G01N 33/54373 (20130101) Original (OR) Class G01N 33/54393 (20130101) G01N 2291/0255 (20130101) G01N 2291/0256 (20130101) G01N 2291/0427 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128734 | MERETSKA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Maryna Leonidivna MERETSKA (Cambridge, Massachusetts); Soon Wei Daniel LIM (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | An optical device includes a membrane. The membrane includes a plurality of apertures extending at least partially through a thickness of the membrane. The membrane is configured to structure incoming light having a wavelength to produce modified light. The wavelength of the incoming light in vacuum is in a range of ultraviolet light and mid-infrared. The membrane is configured to reflect the modified light away from the membrane or transmit the modified light through the membrane. A separation between each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A width of each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A length of each of the plurality of apertures is wavelength-scale relative to the wavelength of the incoming light. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512560 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class G02B 5/1833 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128845 | Lentz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Joshua Lentz (Niceville, Florida) |
| ABSTRACT | A projector includes a beam homogenizer receiving light from a light source and creating a predetermined illumination, and a spatial light modulator including grating stages to receive the predetermined illumination. Each grating stage may include a plurality of pixels where corresponding pixels in the grating stages are aligned with one another. Each of the pixels may include a liquid crystal layer disposed between two substrates, where a pixel is switchable by applying a voltage thereto, with a grating period of the pixel selected such that, when the voltage is applied to the pixel and light is passed therethrough, optical energy from the light in plus and minus first orders is deflected toward sides of the pixel and optical energy from a zero order of the light is allowed to pass through the pixel, with a polarization state of the light maintained through the pixel. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/569247 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 5/18 (20130101) G02B 27/4233 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/29 (20130101) G02F 1/139 (20130101) Original (OR) Class G02F 1/292 (20130101) G02F 1/1313 (20130101) G02F 1/13363 (20130101) G02F 1/13439 (20130101) G02F 1/13471 (20130101) G02F 1/133711 (20130101) G02F 1/133788 (20130101) G02F 2203/04 (20130101) G02F 2203/07 (20130101) G02F 2203/22 (20130101) G02F 2203/48 (20130101) Pictorial Communication, e.g Television H04N 9/3164 (20130101) H04N 9/3167 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129071 | Pandarinath et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia); Georgia Tech Research Corporation (Atlanta, Georgia); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chethan Pandarinath (Decatur, Georgia); Mohammadreza Keshtkaran (Atlanta, Georgia); Yahia Hassan Ali (Atlanta, Georgia); Lahiru Neth Wimalasena (Atlanta, Georgia); Andrew Robert Sedler (Atlanta, Georgia); Lee Eugene Miller (Chicago, Illinois); Josephine Jane Wallner (Chicago, Illinois); Xuan Ma (Chicago, Illinois); Ali Farshchian (Chicago, Illinois); Brianna Marie Karpowicz (Atlanta, Georgia) |
| ABSTRACT | The disclosures relates to systems and methods for using a trained alignment neural network along with a trained latent representation model to achieve accurate alignment between complex neural signals arising from co-variation across neuron populations over time and their intended motor control that can be invariant for a much longer period without supervised recalibrations. In one implementation, the method may include receiving neural data for a period of time from one or more sensors. The method may further include transforming the neural data to generate aligned variables using a trained alignment network. The method may also include processing the aligned variables through a trained latent model to determine a latent spatiotemporal representation of one or more brain state variables for the period of time and decoding the latent spatiotemporal representation into a brain state for the period of time. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512339 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/015 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/061 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129436 | Andreopoulos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Andreopoulos (San Jose, California); Dharmendra S. Modha (San Jose, California); Andrew Stephen Cassidy (Austin, Texas); Brian Seisho Taba (San Jose, California); Carmelo Di Nolfo (San Jose, California); Hartmut Penner (San Jose, California); John Vernon Arthur (San Jose, California); Jun Sawada (Austin, Texas); Myron D. Flickner (San Jose, California); Pallab Datta (San Jose, California); Rathinakumar Appuswamy (San Jose, California) |
| ABSTRACT | Systems are provided that can produce symbolic and numeric representations of the neural network outputs, such that these outputs can be used to validate correctness of the implementation of the neural network. In various embodiments, a description of an artificial neural network containing no data-dependent branching is read. Based on the description of the artificial neural network, a symbolic representation is constructed of an output of the artificial neural network, the symbolic representation comprising at least one variable. The symbolic representation is compared to a ground truth symbolic representation, thereby validating the neural network system. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/077759 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2365 (20190101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129563 | Austin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Todd Austin (Ann Arbor, Michigan); Valeria Bertacco (Ann Arbor, Michigan); Mark Gallagher (Ann Arbor, Michigan); Baris Kasikci (Ann Arbor, Michigan) |
| ABSTRACT | A computer system includes an ensemble moving target defense architecture that protects the computer system against attack using one or more composable protection layers that change each churn cycle, thereby requiring an attacker to acquire information needed for an attack (e.g., code and pointers) and successfully deploy the attack, before the layers have changed state. Each layer may deploy a respective attack information asset protection providing multiple respective attack protections each churn cycle, wherein the respective attack information asset protections may differ. |
| FILED | Thursday, December 30, 2021 |
| APPL NO | 17/566053 |
| CURRENT CPC | Electric Digital Data Processing G06F 8/65 (20130101) G06F 21/552 (20130101) G06F 21/554 (20130101) G06F 21/566 (20130101) G06F 21/577 (20130101) Original (OR) Class G06F 21/602 (20130101) G06F 2221/0751 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129709 | Canal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Canal (Atlanta, Georgia); Christopher John Rozell (Atlanta, Georgia); Stefano Fenu (Atlanta, Georgia); Mark Davenport (Atlanta, Georgia) |
| ABSTRACT | Systems and methods for preference and similarity learning arc disclosed. The systems and methods improve efficiency for both searching datasets and embedding objects within the datasets. The systems and methods for preference embedding include identifying paired comparisons closest to a user's true preference point. The processes include removing obvious paired comparisons and/or ambiguous paired comparisons from subsequent queries The systems and methods for similarity learning include providing larger rank orderings of tuples to increase the context of the information in a dataset In each embodiment, the systems and methods can embed user responses in a Euclidean space such that distances between objects are indicative of user preference or similarity. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 17/428598 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/11 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6264 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129742 | Andreopoulos et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Andreopoulos (San Jose, California); Dharmendra S. Modha (San Jose, California); Carmelo Di Nolfo (San Jose, California); Myron D. Flickner (San Jose, California); Andrew Stephen Cassidy (Austin, Texas); Brian Seisho Taba (San Jose, California); Pallab Datta (San Jose, California); Rathinakumar Appuswamy (San Jose, California); Jun Sawada (Austin, Texas) |
| ABSTRACT | Simulation and validation of neural network systems is provided. In various embodiments, a description of an artificial neural network is read. A directed graph is constructed comprising a plurality of edges and a plurality of nodes, each of the plurality of edges corresponding to a queue and each of the plurality of nodes corresponding to a computing function of the neural network system. A graph state is updated over a plurality of time steps according to the description of the neural network, the graph state being defined by the contents of each of the plurality of queues. Each of a plurality of assertions is tested at each of the plurality of time steps, each of the plurality of assertions being a function of a subset of the graph state. Invalidity of the neural network system is indicated for each violation of one of the plurality of assertions. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/077709 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2379 (20190101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129743 | Sawada et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Sawada (Austin, Texas); Rathinakumar Appuswamy (San Jose, California); John Vernon Arthur (San Jose, California); Andrew Stephen Cassidy (Austin, Texas); Pallab Datta (San Jose, California); Michael Vincent DeBole (Poughkeepsie, New York); Steven Kyle Esser (San Jose, California); Dharmendra S. Modha (San Jose, California) |
| ABSTRACT | Neural network accelerator output ranking is provided. In various embodiments, a system comprises a data memory; a memory controller configured to access the data memory; a plurality of comparators configured in a tree; a register; and a two-way comparator. The memory controller is configured to provide a first plurality of values from the data memory to the comparator tree. The comparator tree is configured to perform a plurality of concurrent pairwise comparisons of the first plurality of values to arrive at a first greatest value of the first plurality of values. The two-way comparator is configured to output the greater of the greatest value from the comparator tree and a stored value from the register. The register is configured to store the output of the two-way comparator. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/078712 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129769 | Sawada et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Sawada (Austin, Texas); Dharmendra S. Modha (San Jose, California); John Vernon Arthur (San Jose, California); Andrew Stephen Cassidy (Austin, Texas); Pallab Datta (San Jose, California); Rathinakumar Appuswamy (San Jose, California); Tapan Kumar Nayak (San Jose, California); Brian Kumar Taba (San Jose, California); Carlos Ortega Otero (Los Angeles, California); Filipp Akopyan (New Windsor, New York); Arnon Amir (San Jose, California); Nathaniel Joseph McClatchey (San Jose, California) |
| ABSTRACT | Modular neural network computing apparatus are provided with distributed neural network storage. In various embodiments, a neural inference processor comprises a plurality of neural inference cores, at least one model network interconnecting the plurality of neural inference cores, and at least one activation network interconnecting the plurality of neural inference cores. Each of the plurality of neural inference cores comprises memory adapted to store input activations, output activations, and a neural network model. The neural network model comprises synaptic weights, neuron parameters, and neural network instructions. The at least one model network is configured to distribute the neural network model among the plurality of neural inference cores. Each of the plurality of neural inference cores is configured to apply the synaptic weights to input activations from its memory to produce a plurality of output activations to its memory. The at least one activation network is configured to provide input activations to each of the plurality of neural inference cores and to obtain output. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/077720 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) G06N 5/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220130058 | Chang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chia Y. Chang (San Marcos, California); Caprice A. Wilbur (San Diego, California); Robert K. Pina (Ramona, California); Julian S. Brody (Southampton, New York) |
| ABSTRACT | A tracking system for a target flight vehicle includes at least two sensor nodes that are positioned at geographically diverse locations relative to a launch site from which the target flight vehicle is launched. The sensor nodes have a lens and a visible camera that captures images of an anticipated launch trajectory for the target flight vehicle. The sensor nodes determine position data for the target flight vehicle including timing, azimuth, and elevation based on the captured images. A fusion processing engine is communicatively coupled to the at least two sensor nodes for receiving and integrating the position data. The data is integrated to determine real-time state vectors including a velocity and a three-dimensional position for the target flight vehicle. The state vectors are sent to a range network that is configured to implement a flight termination system for the target flight vehicle based on the state vectors. |
| FILED | Tuesday, October 27, 2020 |
| APPL NO | 17/081247 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 11/12 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/32 (20130101) G06K 2009/3291 (20130101) Image Data Processing or Generation, in General G06T 7/292 (20170101) Original (OR) Class G06T 2207/30212 (20130101) G06T 2207/30241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220130866 | Demkov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander A. Demkov (Austin, Texas); J. Elliott Ortmann (Austin, Texas); Agham Posadas (Round Rock, Texas) |
| ABSTRACT | Some embodiments of the present technology simplify the process of producing SOI wafers significantly compared to traditional methods. Furthermore, various embodiments provide a route for the integration of perovskite transition metal oxide thin films with different properties into SOI wafers. As such films display a wide array of novel electronic, magnetic, and optical phenomena, their integration into technologically-relevant SOI wafers will likely allow for the construction of a wide array of novel devices. |
| FILED | Wednesday, March 04, 2020 |
| APPL NO | 17/436179 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/76248 (20130101) H01L 27/1203 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131254 | SCHUSTER et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (CHICAGO, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DAVID I. SCHUSTER (CHICAGO, Illinois); AZIZA SULEYMANZADE (CAMBRIDGE, Massachusetts); JONATHAN SIMON (CHICAGO, Illinois); ALEXANDER VLADIMIR ANFEROV (CHICAGO, Illinois) |
| ABSTRACT | A nonlinear parametric device includes a planar substrate and a millimeter-wave resonator formed from superconductive material deposited on the planar substrate. When the resonator is cooled below a critical temperature, it exhibits nonlinear kinetic inductance that may be used to implement millimeter-wave nonlinear frequency generation and parametric amplification. Millimeter waves may be coupled into, and out of, the nonlinear parametric device with hollow rectangular electromagnetic waveguides. Niobium nitride is an excellent superconductive material for kinetic inductance due to its high intrinsic sheet inductance, a critical temperature that is higher than many other superconductive materials, and relatively low loss at millimeter-wave frequencies. |
| FILED | Tuesday, March 03, 2020 |
| APPL NO | 17/435565 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/08 (20130101) H01P 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131463 | GIULIANO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | David M. GIULIANO (Cambridge, Massachusetts); David J. PERREAULT (Cambridge, Massachusetts); Robert C.N. PILAWA-PODGURSKI (Cambridge, Massachusetts) |
| ABSTRACT | A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. The converter can be used, for example, to power logic devices in portable battery operated devices. |
| FILED | Friday, December 31, 2021 |
| APPL NO | 17/566750 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/007 (20210501) H02M 3/07 (20130101) H02M 3/155 (20130101) H02M 3/158 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131614 | KOSS et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shawn Christian KOSS (Carmel Valley, California); Murali TUMMALA (Monterey, California); John C. McEACHEN (Carmel, California) |
| ABSTRACT | A method and system for multipulse-pulse position modulation optical transmission that includes selecting a multipulse-pulse position modulation having a symbol alphabet having an upper-bound symbol alphabet size, and determining, based on at least one transmission characteristic associated with a transmitter, a subset of symbols of the selected symbol alphabet capable of being transmitted by the transmitter, the subset of symbols having a set of binary codewords. The method and system may include identifying two-symbol concatenation of binary codewords in the set of binary codewords, calculating a cross correlation of binary codeword in the set of binary code words through every two-symbol concatenation, determining a set of one or more acceptable codeword combinations by eliminating a portion of two-symbol concatenation of codewords corresponding to overlapping peaks in the respective calculated cross correlations, and transmitting, by the transmitter via an optical communication channel, information encoded based on the determined acceptable codeword combinations. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509799 |
| CURRENT CPC | Transmission H04B 10/524 (20130101) Original (OR) Class Transmission of Digital Information, e.g Telegraphic Communication H04L 7/0075 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220125056 | STRIEGLER et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susanne STRIEGLER (Fayetteville, Arkansas); Babloo SHARMA (Fayetteville, Arkansas) |
| ABSTRACT | Disclosed herein are antimicrobial materials comprising a carbohydrate-templated microgel and a plurality of metal ions complexed thereto. The carbohydrate-templated microgel comprises a network copolymer molecule comprising a monoacrylate monomer, a crosslinking monomer, and a ligand monomer and wherein the microgel is prepared by the copolymerization of the monoacrylate monomer, the crosslinking monomer, and the ligand monomer in the presence of a carbohydrate or a carbohydrate derivative. The microgels have antimicrobial activity and allow for implementation of multiple, simultaneous mechanisms of antimicrobial action. |
| FILED | Wednesday, February 05, 2020 |
| APPL NO | 17/428512 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/04 (20130101) A01N 59/20 (20130101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 33/34 (20130101) A61K 47/6903 (20170801) A61K 47/6933 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125057 | BELFORT et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (TROY, New York); HEALTH RESEARCH, INC. (MENANDS, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (TROY, New York); HEALTH RESEARCH, INC. (MENANDS, New York) |
| INVENTOR(S) | Georges BELFORT (Albany, New York); C. Seth PEARSON (Albany, New York); Brian MURRAY (Haverhill, New York); Pankaj Sakharam KARANDE (Troy, New York); Jun Ha KWAK (Troy, New York); Kathleen A. MCDONOUGH (Albany, New York); Zachary Andrew KLOOS (New Haven, Connecticut) |
| ABSTRACT | Disclosed herein are novel anti-microbial peptides with inhibitory activity against M. tuberculosis and streptococcus bacteria. Additionally, a method for designing novel anti-microbial peptides is disclosed. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/523079 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/38 (20130101) A01N 63/50 (20200101) Original (OR) Class Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/10 (20130101) A61K 45/06 (20130101) Peptides C07K 7/08 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125312 | Nazari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Integrated Medical Sensors, Inc. (Irvine, California) |
| ASSIGNEE(S) | Integrated Medical Sensors, Inc. (Irvine, California) |
| INVENTOR(S) | Meisam Honarvar Nazari (Irvine, California); Muhammad Mujeeb-U-Rahman (Irvine, California); Mehmet Sencan (Tustin, California) |
| ABSTRACT | Monitoring of one or more key indicators can provide powerful insights into operation and state of different physical systems. For example, continuous monitoring of multiple analyte in body will allow for detailed insights into personal health and will allow for preventative health management. In this application, we present an ultra-small scale wireless sensing platform capable of long-term wireless in-vivo sensing. The key for extreme miniaturization lies in ultra-low-power compact design and lithographic integration of key system components. The key to low cost is using standard technologies and scalable manufacturing. For example, using standard semiconductor technologies for sensing, processing and wireless operation paves way to a low-cost integrated wireless sensing technology. Modern semiconductor technologies provide the capability to provide low-power and yet powerful electronics functionality in a small (mm-scale) size and wireless operation at high frequency. Furthermore, these technologies also present the possibility of integrating different components through wafer-scale lithographic integration. This application presents optimal design and processing methods for a small wireless multi-analyte sensing platform that can be used to monitor multiple analyte such as glucose, lactate, Urea and other physicochemical quantities and operates wirelessly. The design techniques and processing methods presented in this application can be used for a multitude of other applications and are not limited to those described here. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/551093 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/002 (20130101) A61B 5/0031 (20130101) Original (OR) Class A61B 5/1473 (20130101) A61B 5/7275 (20130101) A61B 5/14532 (20130101) A61B 2560/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125324 | BERSON et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ROBERT ERIC BERSON (Louisville, Kentucky); SHAHAB GHAFGHAZI (Louisville, Kentucky); JAVAD HASHEMI (Louisville, Kentucky) |
| ABSTRACT | A non-invasive method of assessing a coronary stenosis or other blockage in an artery or other vasculature is based on determination of a blood flow characteristic. In some embodiments, the blood flow characteristic is a fractional flow reserve determined using a statistical correlation of experimentally determined physiological factors and anatomical factors. In other embodiments, the blood flow characteristic is a blood flow rate determined using machine learning techniques. In further embodiments, the blood flow rate determined using machine learning techniques is a physiological factor used in determining the fractional flow reserve. |
| FILED | Monday, February 10, 2020 |
| APPL NO | 17/428086 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/021 (20130101) A61B 5/024 (20130101) A61B 5/029 (20130101) Original (OR) Class A61B 5/02028 (20130101) A61B 5/7264 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125426 | Khanicheh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | EnVision Endoscopy, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azadeh Khanicheh (Somerville, Massachusetts); Amos Cruz (Wrentham, Massachusetts) |
| ABSTRACT | A method cinches a suture. The method provides a cinch having a suture capturing portion configured to capture a suture, a cinch lock coupled with the suture capturing portion, and a cinch anchor having a lumen. The suture capturing portion is extended out of the lumen to capture the suture. The suture is captured by the suture capturing portion. The suture capturing portion is retracted into the lumen of the cinch anchor. The suture is cinched between the cinch lock and the cinch anchor. |
| FILED | Saturday, October 23, 2021 |
| APPL NO | 17/508989 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/018 (20130101) A61B 17/0469 (20130101) A61B 17/0485 (20130101) A61B 17/0487 (20130101) Original (OR) Class A61B 2017/00358 (20130101) A61B 2017/0488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125514 | Zharov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Bioventures, LLC (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Pavlovich Zharov (Little Rock, Arkansas); Ekaterina Galanzha (Little Rock, Arkansas) |
| ABSTRACT | A device and method of using the device to detect the presence and composition of clots and other target objects in a circulatory vessel of a living subject is described. In particular, devices and methods of detecting the presence and composition of clots and other target objects in a circulatory vessel of a living subject using in vivo photoacoustic flow cytometry techniques is described. |
| FILED | Friday, October 08, 2021 |
| APPL NO | 17/496995 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 5/0095 (20130101) A61B 5/412 (20130101) A61B 5/415 (20130101) A61B 5/416 (20130101) A61B 5/418 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/1495 (20130101) A61B 5/02007 (20130101) A61B 5/4839 (20130101) A61B 5/7282 (20130101) A61B 5/7405 (20130101) A61B 5/7455 (20130101) A61B 5/14535 (20130101) A61B 8/06 (20130101) A61B 8/08 (20130101) A61B 8/481 (20130101) A61B 18/245 (20130101) Original (OR) Class A61B 18/1815 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 49/22 (20130101) Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/30 (20130101) B03C 1/288 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/1702 (20130101) G01N 29/2418 (20130101) G01N 29/4427 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125590 | FRIIS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth Annamaria FRIIS (Lawrence, Kansas); John Patrick DOMANN (Lawrence, Kansas) |
| ABSTRACT | There is a need for methods that can produce piezoelectric composites having suitable physical characteristics and also optimized electrical stimulatory proper-ties. The present application provides piezo-electric composites, including tissue-stimu-lating composites, as well as methods of making such composites, that meet these needs. In embodiments, methods of making a spinal implant are provided. The methods suitably comprise preparing a thermoset, thermoplastic or thermoset/thermoplastic, or copolymer polymerizable matrix, dispersing a plurality of piezoelectric particles in the polymerizable matrix to generate dispersion, shaping the dispersion, inducing an electric polarization in the piezoelectric particles in the shaped dispersion, wherein at least 40% of the piezoelectric particles form chains. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/336946 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/4455 (20130101) A61F 2/30771 (20130101) Original (OR) Class A61F 2002/2821 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/50 (20130101) A61L 27/446 (20130101) A61L 2430/38 (20130101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 43/003 (20130101) B29C 45/0001 (20130101) B29C 48/022 (20190201) B29C 49/0005 (20130101) B29C 51/002 (20130101) B29C 71/0072 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 41/37 (20130101) H01L 41/183 (20130101) H01L 41/257 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125735 | Lipke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Auburn University (Auburn, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth A. Lipke (Auburn, Alabama); Wen Jun Seeto (Auburn, Alabama); Yuan Tian (Auburn, Alabama) |
| ABSTRACT | The devices, methods, and compositions disclosed herein accomplish robust cell encapsulation in polymer microparticles using a vertically oriented microfluidic device. A hydrophilic polymer precursor solution is flowed into a first inlet channel, which extends inward from an upper surface of the device housing. A hydrophobic fluid is flowed into a second inlet channel, which extends inward from a lower surface of the device housing. The two inlet channels meet at a junction, and an outlet channel extends away from the two inlet channels. When the two inwardly flowing streams meet at the junction, the polymer precursor solution disperses into the hydrophobic fluid. The dispersed precursor droplets are photopolymerized into microparticles as they travel through the outlet channel. The resulting microparticles are highly uniform, and are larger than conventionally formed microparticles. Cells of varying types can be encapsulated with high viability and spatial uniformity. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515970 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0019 (20130101) A61K 9/5052 (20130101) A61K 9/5089 (20130101) Original (OR) Class A61K 35/34 (20130101) A61K 35/44 (20130101) A61K 35/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) Apparatus for Enzymology or Microbiology; C12M 3/065 (20130101) C12M 23/34 (20130101) C12M 25/10 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0012 (20130101) C12N 5/069 (20130101) C12N 5/0696 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125820 | Mitragotri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Samir Mitragotri (Lexington, Massachusetts); Marta Broto (Barcelona, Spain); Kathryn M. Camacho (Los Angeles, California); Stefano Menegatti (Raleigh, North Carolina) |
| ABSTRACT | Compounds and pharmaceutical formulations containing these compounds are described. Also described are methods of making and using the compounds. The compounds include nucleobases, nucleobase analogues, or combinations thereof. In one embodiment, a nucleobase analogue is combined with doxorubicin and encapsulated within a liposome for use in inhibiting or preventing the growth of cancer cells. Further described are pharmaceutical compositions containing two or more therapeutically active agents encapsulated within a vesicle, such as a liposome, wherein the molar ratio of the agents provides a synergistic therapeutic effect. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/517826 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1273 (20130101) A61K 31/506 (20130101) A61K 31/513 (20130101) A61K 31/7072 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126191 | REED et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of South Florida (Tampa, Florida) |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida) |
| INVENTOR(S) | KYLE REED (TAMPA, Florida); SEOK HUN KIM (TAMPA, Florida) |
| ABSTRACT | A method, apparatus, or system for reducing gait asymmetry is disclosed. The method, apparatus, or system may include measuring one or more gait parameters of an individual; calculating a joint metric based on the measured one or more gait parameters; and signaling an adjustment of an amount of one or more perturbation techniques based on the joint metric for reducing asymmetry in a gait pattern of the individual. The one or more perturbation techniques include asymmetric rhythmic auditory cueing making a first audible cue with a first cue duration for one leg of the individual and a second audible cue with a second cue duration for another leg of the individual. Here, the first cue duration is different from the second cue duration. Other aspects, embodiments, and features are also claimed and described. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511332 |
| CURRENT CPC | Apparatus for Physical Training, Gymnastics, Swimming, Climbing, or Fencing; Ball Games; Training Equipment A63B 22/0292 (20151001) A63B 24/0062 (20130101) A63B 71/0622 (20130101) A63B 71/0686 (20130101) Original (OR) Class A63B 2024/0093 (20130101) A63B 2071/0625 (20130101) A63B 2214/00 (20200801) A63B 2220/22 (20130101) A63B 2220/24 (20130101) A63B 2220/52 (20130101) A63B 2220/62 (20130101) A63B 2220/803 (20130101) A63B 2220/807 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126257 | Gao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Ruixuan Gao (Cambridge, Massachusetts); Ishan Gupta (Cambridge, Massachusetts); Edward S. Boyden (Chestnut Hill, Massachusetts) |
| ABSTRACT | A method for synthesizing nanoparticles by sonofragmentation includes dispersing ultra-thin substrate units in a solvent chosen for suitability for sonofragmentation of the substrate, forming a suspension; ultrasonicating the suspension for a length of time sufficient to fragment the substrate into nanoparticles that are dispersed in the solvent; and evaporating the solvent. Solvent exchange with a second solvent may be performed. The synthesized nanoparticles are highly crystalline and monodispersed. The surface of the synthesized nanoparticles may be functionalized by choosing the solvents according to chemistry related to the intended surface functionalization of the synthesized nanoparticles, by adding surfactants to one or more of the solvents, and/or by performing ligand exchange or chemical modification to replace surface-bonded solvent or surfactant molecules with other functional groups to produce nanoparticles having the desired surface functionalization. |
| FILED | Wednesday, September 01, 2021 |
| APPL NO | 17/464651 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/10 (20130101) Original (OR) Class Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126357 | Rohatgi et al. |
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| FUNDED BY |
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| APPLICANT(S) | UWM Research Foundation, Inc. (Milwaukee, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pradeep Rohatgi (Milwaukee, Wisconsin); Michael Beining (Brookfield, Wisconsin); Kaustubh Kishore Rane (Milwaukee, Wisconsin); Swaroop K. Behera (Milwaukee, Wisconsin); Amir Kordijazi (Albany, New York) |
| ABSTRACT | Exemplary articles may comprise a surface alloyed layer, a base metal comprising a steel, and a transitional layer between the surfaced alloyed layer and the base metal. The surface alloyed layer may comprise nickel (Ni), chromium (Cr), manganese (Mn), molybdenum (Mo), silicon (Si), or combinations thereof. Exemplary methods of making an article may comprise coating a portion of a sand mold with a metal slurry, pouring a molten steel alloy onto the sand mold, and removing the article from the sand mold. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511171 |
| CURRENT CPC | Foundry Moulding B22C 9/02 (20130101) Original (OR) Class B22C 9/12 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 1/00 (20130101) Alloys C22C 35/005 (20130101) C22C 38/02 (20130101) C22C 38/04 (20130101) C22C 38/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126627 | Sheffield et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brigham Young University (Provo, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Sheffield (Provo, Utah); Larry L. Howell (Orem, Utah); Kendall Hal Seymour (Springville, Utah) |
| ABSTRACT | A method and apparatus for connected deployable arms off of cylindrical surfaces including an outer cylinder defining an outer circumference and an inner cylinder concentric with the outer cylinder around a central aperture, one or more primary developable mechanisms linked to one or more secondary developable mechanisms. The deployable arms transition from a first closed state wherein the primary developable mechanisms and secondary developable mechanisms are contained entirely within the outer cylinder outer circumference to a second open state wherein the inner cylinder rotates relative to the outer cylinder, forcing the primary developable mechanisms and secondary developable mechanisms to extend outside the outer cylinder outer circumference. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/429551 |
| CURRENT CPC | Vehicle Wheels; Castors; Axles for Wheels or Castors; Increasing Wheel Adhesion B60B 15/12 (20130101) B60B 19/02 (20130101) Original (OR) Class B60B 19/04 (20130101) B60B 2900/551 (20130101) Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/027 (20130101) B64C 2201/042 (20130101) B64C 2201/108 (20130101) Earth Drilling, e.g Deep Drilling; Obtaining Oil, Gas, Water, Soluble or Meltable Materials or a Slurry of Minerals From Wells E21B 10/327 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127148 | Leventis et al. |
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| FUNDED BY |
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| APPLICANT(S) | Aerogel Technologies, LLC (Boston, Massachusetts) |
| ASSIGNEE(S) | Aerogel Technologies, LLC (Boston, Massachusetts) |
| INVENTOR(S) | Nicholas Leventis (Rolla, Missouri); Anand G. Sadekar (Rolla, Missouri); Naveen Candrasekaran (Rolla, Missouri); Chariklia Sotiriou-Leventis (Rolla, Missouri) |
| ABSTRACT | Three-dimensional nanoporous aerogels and suitable preparation methods are provided. Nanoporous aerogels may include a carbide material such as a silicon carbide, a metal carbide, or a metalloid carbide. Elemental (e.g., metallic or metalloid) aerogels may also be produced. In some embodiments, a cross-linked aerogel having a conformal coating on a sol-gel material is processed to form a carbide aerogel, metal aerogel, or metalloid aerogel. A three-dimensional nanoporous network may include a free radical initiator that reacts with a cross-linking agent to form the cross-linked aerogel. The cross-linked aerogel may be chemically aromatized and chemically carbonized to form a carbon-coated aerogel. The carbon-coated aerogel may be suitably processed to undergo a carbothermal reduction, yielding an aerogel where oxygen is chemically extracted. Residual carbon remaining on the surface of the aerogel may be removed via an appropriate cleaning treatment. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570443 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 32/05 (20170801) C01B 32/90 (20170801) C01B 32/97 (20170801) C01B 32/956 (20170801) Original (OR) Class C01B 32/991 (20170801) Technical Subjects Covered by Former US Classification Y10T 428/249953 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127155 | Talapin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dmitri V. Talapin (La Grange Park, Illinois); Vishwas Srivastava (Chicago, Illinois) |
| ABSTRACT | Methods of synthesizing colloidal ternary Group III-V nanocrystals are provided. Also provided are the colloidal ternary Group III-V nanocrystals made using the methods. In the methods, molten inorganic salts are used as high temperature solvents to carry out cation exchange reactions that convert binary nanocrystals into ternary nanocrystals. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567499 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 15/003 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127198 | WEIMER et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | ALAN WEIMER (Niwot, Colorado); BOLA YOON (Boulder, Colorado); RISHI RAJ (Boulder, Colorado); REBECCA O'TOOLE (Boulder, Colorado) |
| ABSTRACT | Methods of flash sintering have been developed in which particle are initially coated with thin layers by atomic layer deposition (ALD). Examples are provided in which 8 mol % yttria-stabilized zirconia (8YSZ) particles are coated with small quantities of Al2O3 by particle atomic layer deposition (ALD). Sintered materials that result from the process have been characterized. Sintered materials having unique characteristics are also described. |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 17/434719 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 35/64 (20130101) C04B 35/117 (20130101) C04B 35/563 (20130101) C04B 35/565 (20130101) C04B 35/581 (20130101) C04B 35/4885 (20130101) C04B 35/6281 (20130101) C04B 35/62813 (20130101) C04B 35/62815 (20130101) C04B 35/62836 (20130101) C04B 35/62884 (20130101) Original (OR) Class C04B 35/62889 (20130101) C04B 35/62894 (20130101) C04B 35/62897 (20130101) C04B 2235/66 (20130101) C04B 2235/785 (20130101) C04B 2235/786 (20130101) C04B 2235/3206 (20130101) C04B 2235/3208 (20130101) C04B 2235/3217 (20130101) C04B 2235/3225 (20130101) C04B 2235/3246 (20130101) C04B 2235/3821 (20130101) C04B 2235/3826 (20130101) C04B 2235/3865 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/56 (20130101) C23C 16/403 (20130101) C23C 16/4417 (20130101) C23C 16/45555 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1253 (20130101) H01M 2008/1293 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127739 | Camacho Chico et al. |
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| FUNDED BY |
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| APPLICANT(S) | Lucy Mar Camacho Chico (Corpus Christi, Texas); Mohammad U. Shafiq (Montgomery, Texas) |
| ASSIGNEE(S) | Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Lucy Mar Camacho Chico (Corpus Christi, Texas); Mohammad U. Shafiq (Montgomery, Texas) |
| ABSTRACT | Provided herein is an electrodialysis metathesis (EDM) system that has at least one stack or quad of compartments arranged so each compartment is in fluid communication with its adjacent compartment via alternating cation- and anion-exchange membranes. The compartments in a stack are a feed compartment, a substitution salt solution compartment, a first concentrated compartment and a second concentrated compartment. Also provided are processes and methods for separating or recovering a metal, for example, a rare earth element, or a salt or a combination thereof from a salt-containing water. Simultaneous metathesis reactions and electrodialysis across the stack recovers one or more metal or salts from the salt-containing water which desalinates the salt-containing water. |
| FILED | Friday, October 23, 2020 |
| APPL NO | 17/079346 |
| CURRENT CPC | Processes for the Electrolytic Production, Recovery or Refining of Metals; Apparatus Therefor C25C 1/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128346 | Lipson et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michal Lipson (New York, New York); Xingchen Ji (New York, New York); Alexander Klenner (New York, New York); Xinwen Yao (Baltimore, Maryland); Yu Gan (Harriston, New Jersey); Alexander L. Gaeta (New York, New York); Christine P Hendon (Bronx, New York) |
| ABSTRACT | A method of providing optical coherence tomography (OCT) imaging may comprise using an on-chip frequency comb source interfaced with an OCT system by a circulator as an imaging source and reconstructing OCT images from resulting spectral data from target tissue illuminated by the imaging source. |
| FILED | Tuesday, July 06, 2021 |
| APPL NO | 17/367884 |
| CURRENT CPC | Measuring Length, Thickness or Similar Linear Dimensions; Measuring Angles; Measuring Areas; Measuring Irregularities of Surfaces or Contours G01B 9/02008 (20130101) Original (OR) Class G01B 9/02091 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128357 | HORVAT |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITYCORPORATION FOR ATMOSPHERIC RESEARCH (Boulder, Colorado) |
| ASSIGNEE(S) | UNIVERSITYCORPORATION FOR ATMOSPHERIC RESEARCH (Boulder, Colorado) |
| INVENTOR(S) | Christopher HORVAT (Providence, Rhode Island) |
| ABSTRACT | A method (100) and system (500) for determining a floe size distribution (350), (516) for a plurality of floes within a geographical area (204), comprising determining a chord length distribution (512) for the geographical area (204), the chord length distribution (512) comprising a plurality of measured floe chord lengths, and determining the floe size distribution (350, 516) over the geographical area (204) based on the chord length distribution (512), the floe size distribution (350, 516) comprising a plurality of floe diameters (402). |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/429084 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 13/00 (20130101) Original (OR) Class G01C 21/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128464 | ESCARRA et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew David ESCARRA (New Orleans, Louisiana); Adam OLLANIK (Boulder, Colorado) |
| ABSTRACT | A method for measuring a refractive index of a medium includes exciting a first antisymmetric resonance of a first metasurface, including a first periodic array of resonators formed on a substrate surface, with illumination incident on the first metasurface at a non-normal incidence angle with respect to the substrate surface, the first metasurface including the medium encapsulating the first periodic array of resonators. The method also includes determining a refractive index of the medium from a first amplitude of a first transmitted signal that includes a portion of the illumination transmitted through the first metasurface. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567677 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/4133 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128734 | MERETSKA et al. |
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| FUNDED BY |
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| APPLICANT(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Maryna Leonidivna MERETSKA (Cambridge, Massachusetts); Soon Wei Daniel LIM (Cambridge, Massachusetts); Federico CAPASSO (Cambridge, Massachusetts) |
| ABSTRACT | An optical device includes a membrane. The membrane includes a plurality of apertures extending at least partially through a thickness of the membrane. The membrane is configured to structure incoming light having a wavelength to produce modified light. The wavelength of the incoming light in vacuum is in a range of ultraviolet light and mid-infrared. The membrane is configured to reflect the modified light away from the membrane or transmit the modified light through the membrane. A separation between each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A width of each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A length of each of the plurality of apertures is wavelength-scale relative to the wavelength of the incoming light. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512560 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) Original (OR) Class G02B 5/1833 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128902 | HSU et al. |
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| FUNDED BY |
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| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keng HSU (Tempe, Arizona); Placid Ferreira (Champaign, Illinois); Bruno Azeredo (Champaign, Illinois) |
| ABSTRACT | An imprinting platform including a noble metal catalyst, a semiconductor substrate, and a pre-patterned polymer stamp, where the catalyst is attached to the stamp, and related methods and articles. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/517952 |
| CURRENT CPC | Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0273 (20130101) H01L 21/3063 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129654 | SHARMA |
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| FUNDED BY |
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| APPLICANT(S) | University of Rochester (Rochester, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gaurav SHARMA (Webster, New York) |
| ABSTRACT | A dual-modulated QR code (DMQR code) is in the format of a conventional QR code but uses elongated markers instead of black squares in the code modules. The positions of the markers within the DMQR code represent a nonconfidential primary message, and the orientations of the markers within the modules of the DMQR code represent a confidential secondary message. |
| FILED | Tuesday, October 19, 2021 |
| APPL NO | 17/505081 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 7/1417 (20130101) Original (OR) Class G06K 19/06037 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129709 | Canal et al. |
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| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gregory Canal (Atlanta, Georgia); Christopher John Rozell (Atlanta, Georgia); Stefano Fenu (Atlanta, Georgia); Mark Davenport (Atlanta, Georgia) |
| ABSTRACT | Systems and methods for preference and similarity learning arc disclosed. The systems and methods improve efficiency for both searching datasets and embedding objects within the datasets. The systems and methods for preference embedding include identifying paired comparisons closest to a user's true preference point. The processes include removing obvious paired comparisons and/or ambiguous paired comparisons from subsequent queries The systems and methods for similarity learning include providing larger rank orderings of tuples to increase the context of the information in a dataset In each embodiment, the systems and methods can embed user responses in a Euclidean space such that distances between objects are indicative of user preference or similarity. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 17/428598 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/11 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6264 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129728 | Cui et al. |
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| FUNDED BY |
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| APPLICANT(S) | Qiushi Cui (Tempe, Arizona); Yang Weng (Chandler, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on behalf of Arizona State University (Scottsdale, Arizona) |
| INVENTOR(S) | Qiushi Cui (Tempe, Arizona); Yang Weng (Chandler, Arizona) |
| ABSTRACT | Reinforcement learning (RL)-based recloser control for distribution cables with degraded insulation level is provided. Utilities continuously observe cable failures on aged cables that have an unknown degraded basic insulation level (BIL). One of the root causes is the transient overvoltage (TOV) associated with circuit breaker reclosing. Since it is hard to model TOV due to its complexity, embodiments described herein provide a model-free stochastic control method for reclosers under the existence of uncertainty and noise. Concretely, to capture high-dimensional dynamics patterns, the recloser control problem is formulated herein by incorporating the temporal sequence reward mechanism into a deep Q-network (DQN). Meanwhile, physical understanding of the problem is embedded into the action probability allocation to develop an infeasible-action-space-elimination algorithm. The learning efficiency is proved to be outstanding due to the proposed time sequence reward mechanism and infeasible action elimination method. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511124 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 31/085 (20130101) G01R 31/088 (20130101) Computer Systems Based on Specific Computational Models G06N 3/04 (20130101) Original (OR) Class G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129930 | Cranshaw et al. |
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| FUNDED BY |
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| APPLICANT(S) | Carnegie Mellon University (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin Cranshaw (Pittsburgh, Pennsylvania); Raz Schwartz (New York, New York); Jason I. Hong (Pittsburgh, Pennsylvania); Norman Sadeh-Koniecpol (Pittsburgh, Pennsylvania) |
| ABSTRACT | Computer-based systems and methods for discovering neighborhood clusters in a geographic region, where the clusters have a mix of venues and are determined based on venue check-in data. The mix of venues for the clusters may be based on the social similarity between pairs of venues; or emblematic of certain neighborhood typologies; or emblematic of temporal check-in pattern types; or combinations thereof. The neighborhood clusters that are so discovered through venue-check in data could be used for many commercial and civic purposes. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/572252 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 30/0205 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220130145 | Connary et al. |
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| FUNDED BY |
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| APPLICANT(S) | Pointivo Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Iven Connary (Atlanta, Georgia); Guy Ettinger (Flowery Branch, Georgia); Habib Fathi (Atlanta, Georgia); Jacob Garland (Peachtree Corners, Georgia); Daniel Ciprari (Atlanta, Georgia) |
| ABSTRACT | The systems and methods herein provide improved methodologies for visualization on a user's display of sensor data (e.g., 2D and 3D information obtained from or derived from sensors) for objects, components, or features of interest in a scene. The previously acquired sensor data is processable for concurrent display of objects/features/scene or location visualizations to a user during their real-time navigation of a scene camera during a variety of user visualization activities. Sensor data can be acquired via the operation of vehicles configured with one or more sensors, such as unmanned aerial vehicles, or from other methodologies, or from any other suitable sensor data acquisition activities. Objects etc. for which acquired sensor data can be visualized by a user on a display includes buildings, parts of buildings, and infrastructure elements, among other things. The improved display of information to a user for visualization and information generation therefrom provides significant benefits over prior art display methodologies and exhibits notable utility for user activities such as, inspection, condition assessment, performance assessment, insurance applications, construction, inventorying, building information modeling, asset management and the like. Information derivable from the methodologies herein can be used for machine learning libraries and digital twin processes. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567347 |
| CURRENT CPC | Systems for Controlling or Regulating Non-electric Variables G05D 1/0016 (20130101) G05D 1/0044 (20130101) G05D 1/101 (20130101) Image or Video Recognition or Understanding G06V 20/10 (20220101) G06V 20/176 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131179 | Kyu et al. |
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| FUNDED BY |
|
| APPLICANT(S) | Thein Kyu (Akron, Ohio); Ran Li (Beijing, China PRC) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thein Kyu (Akron, Ohio); Ran Li (Beijing, China PRC) |
| ABSTRACT | A solid-state polymer electrolyte membrane and a supercapacitive lithium-ion battery utilizing the solid-state polymer electrolyte membrane. The solid-state polymer electrolyte membrane comprising a mixture of a lithium salt, a plasticizer, and a co-network of a crosslinkable polyether addition and a crosslinkable amine addition. The co-network is crosslinked, and the solid-state polymer electrolyte membrane is conductive on the order of 10−3 S cm−1. The supercapacitive lithium-ion battery utilizing the solid-state polymer electrolyte membrane has an operating range of between about 0.01 and about 4.3 V without short-circuiting while also having a higher capacity relative to conventional liquid electrolyte lithium-ion batteries. |
| FILED | Monday, August 23, 2021 |
| APPL NO | 17/409036 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) H01M 4/525 (20130101) H01M 4/881 (20130101) H01M 4/5825 (20130101) H01M 10/0525 (20130101) Original (OR) Class H01M 10/0565 (20130101) H01M 2220/20 (20130101) H01M 2300/0082 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131254 | SCHUSTER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (CHICAGO, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | DAVID I. SCHUSTER (CHICAGO, Illinois); AZIZA SULEYMANZADE (CAMBRIDGE, Massachusetts); JONATHAN SIMON (CHICAGO, Illinois); ALEXANDER VLADIMIR ANFEROV (CHICAGO, Illinois) |
| ABSTRACT | A nonlinear parametric device includes a planar substrate and a millimeter-wave resonator formed from superconductive material deposited on the planar substrate. When the resonator is cooled below a critical temperature, it exhibits nonlinear kinetic inductance that may be used to implement millimeter-wave nonlinear frequency generation and parametric amplification. Millimeter waves may be coupled into, and out of, the nonlinear parametric device with hollow rectangular electromagnetic waveguides. Niobium nitride is an excellent superconductive material for kinetic inductance due to its high intrinsic sheet inductance, a critical temperature that is higher than many other superconductive materials, and relatively low loss at millimeter-wave frequencies. |
| FILED | Tuesday, March 03, 2020 |
| APPL NO | 17/435565 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 3/08 (20130101) H01P 7/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131258 | Eid et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aline Eid (Atlanta, Georgia); Jimmy Georges Donald Hester (Atlanta, Georgia); Emmanouil Manos Tentzeris (Atlanta, Georgia) |
| ABSTRACT | The disclosed technology includes device, systems, techniques, and methods for mm-wave energy harvesting utilizing a Rotman-Lens-based rectenna system. An energy harvester system can include one or more antenna, a Rotman Lens having a beam port side and an antenna side in electrical communication with the one or more antenna, and a rectifier network in electrical communication with the beam port side of the Rotman Lens. The energy harvester system can also include a power combining network in electrical communication with the rectifier network and having an output. The rectifier network can include a plurality of rectifiers connected to the beam port side of the Rotman Lens. Further, each of the plurality of rectifiers can include a rectifying diode. The power combining network can include a plurality of bypass diodes. |
| FILED | Thursday, April 30, 2020 |
| APPL NO | 17/607435 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/248 (20130101) Original (OR) Class H01Q 21/065 (20130101) H01Q 25/008 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/001 (20200101) H02J 50/27 (20160201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131662 | MELODIA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tommaso MELODIA (Newton, Massachusetts); Giuseppe Enrico SANTAGATI (Cambridge, Massachusetts) |
| ABSTRACT | A system and method for transmitting data ultrasonically through biological tissue employs a network of a plurality of nodes, at least a portion of the nodes implantable within the biological tissue. At least one implanted node includes a transmitter having an orthogonal frequency division multiplex signal generator to encode an ultrasonic signal for transmission through the biological tissue to an ultrasonic receiver at another node. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/572876 |
| CURRENT CPC | Transmission H04B 11/00 (20130101) H04B 13/005 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0003 (20130101) H04L 1/0009 (20130101) H04L 1/0057 (20130101) H04L 5/0012 (20130101) Original (OR) Class H04L 27/0008 (20130101) H04L 27/2053 (20130101) H04L 27/2602 (20130101) H04L 27/2626 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131922 | Halepovic et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); GEORGIA TECH RESEARCH CORPORATION (Atlanta, Georgia) |
| INVENTOR(S) | Emir Halepovic (Somerset, New Jersey); Tarun Mangla (Chicago, Illinois); Ellen Zegura (Decatur, Georgia); Mostafa Ammar (Smyrna, Georgia) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, selecting a first video service model according to a server hostname determined according to transport layer security (TLS) transaction data associated with a video session transmitted over a network, calculating a plurality of data delivery statistics from the TLS transaction data according to the first video service model, where the plurality of data delivery statistics includes session-level statistics over the video session, transaction-level statistics over each transaction, and temporal feature statistics over intervals of the video session, determining a quality of experience (QoE) metric for the video session from the plurality of data delivery statistics according to a course-grained data QoE model, and adjusting a first network element of the network responsive to the determining the QoE metric for the video session. Other embodiments are disclosed. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/079907 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 65/80 (20130101) Original (OR) Class H04L 65/4069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220132450 | PELLETIER |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Woods Hole Oceanographic Institution (Woods Hole, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Leo-Paul PELLETIER (East Falmouth, Massachusetts) |
| ABSTRACT | A system and method enabling precise range estimation and time synchronization between a first object such as a vehicle having a primary communications mechanism and an interconnected first controller, and a second object having a secondary communications mechanism and an interconnected second controller. The primary sends communications into the environment and the secondary receives them; the secondary then sends replies to the primary. The communications have information for determining range between the two objects and for comparing the second object's internal clock with a more accurate clock of the first object. Repeated exchanges of communications between the two objects enables additional precision of range as well as time synchronization information. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509860 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 11/02 (20130101) Wireless Communication Networks H04W 4/023 (20130101) H04W 4/44 (20180201) H04W 56/006 (20130101) H04W 56/0015 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220125301 | Hart et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Leica Microsystems Inc. (Buffalo Grove, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert H. Hart (Cary, North Carolina); Dorothy M. Branco (Durham, North Carolina); Eric L. Buckland (Hickory, North Carolina); Micaela R. Mendlow (Jersey City, New Jersey) |
| ABSTRACT | Systems for determining an apex of curvature In an image, obtained from, a sample are provided. The systems include—an imaging system configured to obtain a plurality of scans of a sample using a radial pattern; and a processor associated with the imaging system. The processor is configured to segment and curve fit each of the plurality of scans to a surface of the sample; determine an apex. for each curve associated with each of the plurality of scans; determine a true apex, among all determined apexes using a derivative of least value; calculate an XY offset based on the determined true apex; map the true apex to an origin where X and Y are equal to zero; and adjust the coordinates associated with remaining apexes not determined to be the true apex based on the calculated offset. |
| FILED | Thursday, March 19, 2020 |
| APPL NO | 17/424056 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0025 (20130101) A61B 3/102 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 7/344 (20170101) G06T 2207/10101 (20130101) G06T 2207/30041 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220125938 | MOORE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Edwin G. MOORE (Round Lake, Illinois); Jeffrey S. MOORE (Savoy, Illinois); Yang SONG (Framingham, Massachusetts) |
| ABSTRACT | The present disclosure provides multivalent polymer-peptide conjugate compositions capable of breaking already formed amyloid fibrils. Also provided are methods of treating a subject having or suspected of having Alzheimer's disease by administering a therapeutically effective amount of these multivalent polymer-peptide conjugate compositions. |
| FILED | Monday, January 03, 2022 |
| APPL NO | 17/567667 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/59 (20170801) A61K 47/595 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 14/4711 (20130101) C07K 17/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126277 | Kaphan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | David Kaphan (Oak Park, Illinois); Massimiliano Delferro (Chicago, Illinois); Alon Chapovetsky (Chicago, Illinois); Cynthia Jeanne Jenks (Elmhurst, Illinois); Christopher S. Johnson (Naperville, Illinois) |
| ABSTRACT | A method of turning a catalytic material by altering the charge state of a catalyst support. The catalyst support is intercalated with a metal ion, altering the charge state to alter and/or augment the catalytic activity of the catalyst material. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/077630 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/8892 (20130101) Original (OR) Class B01J 37/0209 (20130101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/54 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126370 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jian Liu (Cary, North Carolina); Shuang Bai (Cary, North Carolina) |
| ASSIGNEE(S) | PolarOnyx, Inc. (Chapel Hill, North Carolina) |
| INVENTOR(S) | Jian Liu (Cary, North Carolina); Shuang Bai (Cary, North Carolina) |
| ABSTRACT | Methods and apparatuses for AM of all-in-one radiation shielding components from multi-material metal alloys, metal matrix, MMCs, and/or gradated compositions of the same are disclosed, comprising: providing an apparatus having: an energy source; a scanner; a powder system for powder(s); a powder delivery system; a shielding gas; and a computer coupled to and configured to control the energy source, scanner, powder system, and powder delivery system to deposit layers of the sample; programming the computer with specifications of the sample; using the computer to control electromagnetic radiation, mixing ratio, and powder deposition parameters based on the specifications of the sample; and using the autofocusing scanner to focus and scan the electromagnetic radiation onto the sample while the powders are concurrently deposited by the powder delivery system onto the sample to create a melting pool to deposit one or more layers onto the sample. Other embodiments are described and claimed. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511073 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/062 (20220101) B22F 1/065 (20220101) B22F 1/068 (20220101) B22F 10/36 (20210101) Original (OR) Class B22F 10/85 (20210101) B22F 12/30 (20210101) B22F 12/49 (20210101) B22F 12/58 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127153 | Frisbie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carl Daniel Frisbie (Saint Paul, Minnesota); Paul J. Dauenhauer (Shoreview, Minnesota); Matthew Alexander Ardagh (Minneapolis, Minnesota) |
| ABSTRACT | A heterogeneous catalysis method for catalyzing the conversion of a first chemical species to a second chemical species includes varying a binding energy of the first chemical species, the second chemical species, or both over time and in the presence of a catalyst. Systems configured to catalyze the conversion of the first chemical species to the second chemical species by varying a binding energy of the first chemical species, the second chemical species, or both over time and in the presence of a catalyst include a sound wave generator, a pressure generator, a piezoelectric material, or a back gate device configured to facilitate the varying of the binding energy of the first chemical species, the second chemical species, or both. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 17/434576 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/087 (20130101) B01J 2219/0801 (20130101) B01J 2219/0892 (20130101) Ammonia; Cyanogen; Compounds Thereof C01C 1/0411 (20130101) C01C 1/0417 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127217 | Stahl et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| INVENTOR(S) | Shannon Stahl (Madison, Wisconsin); Hao Luo (Decatur, Illinois) |
| ABSTRACT | Methods of depolymerizing lignin and products obtained therefrom. The methods include reacting lignin in a liquid solvent comprising an oxidation catalyst with the solvent being in contact with 02 gas. The solvent can include aprotic polar solvents. The oxidation catalyst can include heterogeneous catalysts. The methods can be used in the oxidative catalytic fractionation of raw biomass to generate soluble aromatic monomers and a solid carbohydrate residue. Depolymerized lignin products include phenolic and benzoquinone monomers, such as p-hydroxybenzoic acid, vanillin, syringaldehyde, vanillic acid, and/or syringic acid. |
| FILED | Friday, March 06, 2020 |
| APPL NO | 17/436202 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/183 (20130101) B01J 35/04 (20130101) Acyclic or Carbocyclic Compounds C07C 45/59 (20130101) C07C 51/313 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127396 | Hartmann-Thompson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | 3M INNOVATIVE PROPERTIES COMPANY (St. Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Claire Hartmann-Thompson (Lake Elmo, Minnesota); Mark J. Pellerite (Woodbury, Minnesota); John C. Thomas (St. Paul, Minnesota); Marina M. Kaplun (Woodbury, Minnesota) |
| ABSTRACT | A crosslinkable copolymer is provided. The crosslinkable copolymer has pendant cationic nitrogen-containing groups with some, but not all, of these pendant groups further including a (meth)acryloyl group. The (meth)acryloyl groups can react to form a crosslinked copolymer that is ionically conductive. The crosslinked copolymer can be used to provide an anion exchange membrane that can be used in electrochemical cells such as fuel cells, electrolyzers, batteries, and electrodialysis cells. |
| FILED | Thursday, December 05, 2019 |
| APPL NO | 17/309391 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/14 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/30 (20130101) C08F 212/08 (20130101) C08F 212/18 (20200201) Original (OR) Class Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 13/08 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 50/414 (20210101) H01M 50/497 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127413 | COATES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| INVENTOR(S) | Geoffrey W. COATES (Lansing, New York); Kristina M. HUGAR (Ithaca, New York) |
| ABSTRACT | The invention provides: imidazole and imidazolium compounds of formulas (I) and (II): polymers containing a plurality of imidazolium-containing repeating units of formula (III′): and membranes and devices comprising the polymers. Also provided are methods of making the inventive compounds and polymers. |
| FILED | Tuesday, January 04, 2022 |
| APPL NO | 17/647007 |
| CURRENT CPC | Separation B01D 71/44 (20130101) B01D 71/62 (20130101) Heterocyclic Compounds C07D 233/58 (20130101) C07D 233/60 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/30 (20130101) C08F 12/26 (20130101) C08F 210/14 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/02 (20130101) C08G 61/04 (20130101) Original (OR) Class C08G 61/06 (20130101) C08G 61/08 (20130101) C08G 2261/148 (20130101) C08G 2261/149 (20130101) C08G 2261/418 (20130101) C08G 2261/516 (20130101) C08G 2261/724 (20130101) C08G 2261/1424 (20130101) C08G 2261/3322 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/2231 (20130101) C08J 2323/18 (20130101) Compositions of Macromolecular Compounds C08L 25/18 (20130101) C08L 71/02 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 8/1023 (20130101) H01M 50/411 (20210101) H01M 2300/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127450 | Fujimoto |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cy Fujimoto (Albuquerque, New Mexico) |
| ABSTRACT | A method for synthesizing a poly(phenylene) with high ion selectivity comprises dissolving an alkyl halide poly(phenylene) in a polar aprotic solvent to form a nonaqueous solution and adding an anhydrous nucleophile to the nonaqueous solution to replace the halide of the alkyl halide poly(phenylene) with a cationic group of the nucleophile. The poly(phenylene) can be used in anion exchange membranes. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/569777 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 41/09 (20170101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/10 (20130101) C08G 2261/143 (20130101) C08G 2261/148 (20130101) Compositions of Macromolecular Compounds C08L 65/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127586 | Whiteley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); President And Fellows Of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Whiteley (Brookline, Massachusetts); Philip J. Kranzusch (Brighton, Massachusetts); John Mekalanos (Newton, Massachusetts); James Eaglesham (Boston, Massachusetts) |
| ABSTRACT | The present invention is based, in part, on the discovery and characterization of the CD-NTase family of proteins, as well as compositions comprising CD-NTases, methods of producing nucleotide-based second messengers using such polypeptides, and methods of screening for modulators of the structure, expression, and/or activity of such polypeptides. |
| FILED | Wednesday, September 04, 2019 |
| APPL NO | 17/270234 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) C12N 9/1241 (20130101) Original (OR) Class C12N 11/06 (20130101) C12N 15/10 (20130101) C12N 15/70 (20130101) C12N 15/1137 (20130101) C12N 15/8509 (20130101) C12N 2015/8527 (20130101) C12N 2310/14 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/5023 (20130101) G01N 2333/91245 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127648 | XIONG et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTEGRATED LIPID BIOFUELS LLC (Airway Heights, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xiaochao XIONG (Pullman, Washington); Shulin CHEN (Pullman, Washington) |
| ABSTRACT | The present disclosure provides a method for genetically engineering Yarrowia lipolytica host cell for producing glycolic acid from organic wastes. A subject genetically engineered Y. lipolytica cell comprises the disrupted native genes encoding malate synthase, heterologous enzyme of glyoxylate reductase targeted in the different cellular compartments including mitochondria, peroxisome and cytosol, and a mutant NADP+-dependent malate dehydrogenase. The pathway with a theoretical yield as high as that 1 g of acetic acid can be converted to 1.27 g of glycolic acid without carbon loss was engineered for glycolic acid production. The methods particularly include process for production of volatile fatty acids (VFAs) mainly comprised of acetic acid from organic waste, and then use of resultant VFAs for biosynthesis of glycolic acid by recombinant Y. lipolytica. |
| FILED | Thursday, January 23, 2020 |
| APPL NO | 17/425288 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/16 (20130101) C12N 9/0006 (20130101) C12N 15/52 (20130101) C12N 15/815 (20130101) C12N 2800/102 (20130101) C12N 2810/85 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class Enzymes C12Y 101/0104 (20130101) C12Y 101/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220127651 — MICROBIOMES AND METHODS FOR PRODUCING MEDIUM-CHAIN FATTY ACIDS FROM ORGANIC SUBSTRATES
| US 20220127651 | Donohue et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| ASSIGNEE(S) | WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison, Wisconsin) |
| INVENTOR(S) | Timothy James Donohue (Middleton, Wisconsin); Matthew Scarborough (Madison, Wisconsin); Daniel Noguera (Madison, Wisconsin) |
| ABSTRACT | Microbiome compositions and uses thereof. The microbiome compositions include a set of microbes. The sets of microbes contain members of Lactobacillaceae, Eubacteriaceae, Lachnospiraceae, and Coriobacteriaceae. The number of individual physical microbes in the set constitutes a certain percentage of the total number of individual physical microbes in the microbiome composition. The microbiome compositions can be used for producing medium-chain fatty acids from organic substrates through anaerobic fermentation in a medium. The medium can include lignocellulosic stillage. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571209 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/205 (20210501) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/6409 (20130101) Original (OR) Class C12P 2203/00 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/225 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127744 | WATKINS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | LUMISHIELD TECHNOLOGIES INCORPORATED (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. WATKINS (Pittsburgh, Pennsylvania); Hunaid B. NULWALA (Pittsburgh, Pennsylvania) |
| ABSTRACT | Methods and compositions for improving adhesion of an organic coating applied to a surface of a conductive substrate are provided. In aspects described, at least one reactive metal-based deposit is electrodeposited on a conductive substrate by pulse electrochemical reduction of a metal complex using a pulse scheme, wherein the metal complex is dissolved in a substantially aqueous medium. |
| FILED | Monday, February 03, 2020 |
| APPL NO | 17/427345 |
| CURRENT CPC | Processes for the Electrolytic or Electrophoretic Production of Coatings; Electroforming; Apparatus Therefor C25D 9/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128270 | Ward et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC (Aiken, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick A. Ward (Aiken, South Carolina); Ragaiy Zidan (Aiken, South Carolina) |
| ABSTRACT | Disclosed are high enthalpy thermochemical energy storage materials that exhibit high thermal conductivity and stability at high temperature reaction conditions. Disclosed materials include hydride-based alloys that can undergo high temperature reversible hydrogenation/dehydrogenation reactions without phase change of any metal or metalloid components of the alloy. The materials undergo a reversible exothermic hydrogenation reaction to form a metal hydride and a ternary alloy that includes a high thermal conductivity metal that, in its pure state, would exhibit a phase change at the hydrogenation reaction conditions. |
| FILED | Tuesday, October 27, 2020 |
| APPL NO | 17/080955 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/16 (20130101) Collection, Production or Use of Heat Not Otherwise Provided for F24V 30/00 (20180501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128445 | Hering et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| ASSIGNEE(S) | Aerosol Dynamics Inc. (Berkeley, California) |
| INVENTOR(S) | Susanne Vera Hering (Berkeley, California); Gregory Stephen Lewis (Berkeley, California); Steven Russel Spielman (Oakland, California) |
| ABSTRACT | A method and apparatus to create water vapor supersaturation and particulate counts from an air sample. The method and apparatus include introducing an air sample into a chamber connected to an optical detector and an outlet by pumping at the outlet. The method further includes passing air through the chamber and optical detector in a steady flow, and subsequently closing the inlet while continuing the pumping to expand the air sample and exhaust a portion of the air sample through the optical detector. The walls of the particle chamber are wetted with a fluid such as water, and one portion of the wall is warmer than the other portions such that there is some condensational growth prior to the expansion, and yet more condensational growth during the expansion. The cycles are repeated by continuously repeating the introducing, passing and closing. |
| FILED | Wednesday, January 05, 2022 |
| APPL NO | 17/568940 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/06 (20130101) Original (OR) Class G01N 2015/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128473 | HOUK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC (AIKEN, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | AMANDA L. HOUK (AIKEN, South Carolina); MATTHEW S. WELLONS (AIKEN, South Carolina); ROSS J. SMITH (NORTH AUGUSTA, South Carolina); JOSHUA T. HEWITT (STANDARDSVILLE, Virginia) |
| ABSTRACT | Carbon fiber characterization processes are described that include multi-condition Raman spectroscopy-based examination combined with multivariate data analyses. Methods are a nondestructive material characterization approach that can provide predictions as to carbon fiber bulk physical properties, as well as identification of unknown carbon fiber materials for quality control purposes. The framework of the multivariate analysis methods includes a principal component-based identification protocol including comparison of Raman spectral data from an unknown carbon fiber with a data library of multiple principal component spaces. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/079609 |
| CURRENT CPC | Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 9/12 (20130101) Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/4412 (20130101) G01J 2003/283 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/65 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128483 | FORIEN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jean-Baptiste FORIEN (Livermore, California); Nicholas P. CALTA (San Jose, California); Gabriel Mark GUSS (Manteca, California); Manyalibo Joseph MATTHEWS (Livermore, California) |
| ABSTRACT | A system and method is disclosed for detecting anomalies in an additively manufactured part. An energy source generates a signal forming an optical beam for creating a melt pool in a layer of feedstock material being selectively fused to make a part in an additive manufacturing operation. A sensor is configured to receive a signal reflected from the melt pool. The reflected signal forms a thermal signal indicative of a temperature of the feedstock material at a known location on a layer of the feedstock material while the feedstock material is being fused at the known location. A controller receives and analyzes data relating to the received signal to determine if an anomaly exists at the known location. |
| FILED | Wednesday, October 28, 2020 |
| APPL NO | 17/082855 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/80 (20210101) Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 50/00 (20141201) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/95 (20130101) G01N 21/8806 (20130101) Original (OR) Class G01N 2201/06113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128878 | STRAND et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (Denver, Colorado); THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael T. STRAND (Boulder, Colorado); Christopher BARILE (Reno, Nevada); Tyler S. HERNANDEZ (Boulder, Colorado); Andrew L. YEANG (Boulder, Colorado); Michael D. MCGEHEE (Boulder, Colorado) |
| ABSTRACT | Dynamic windows with adjustable tint give users greater control over flow of light and heat. Reversible metal electrodeposition dynamic windows include (i) a transparent or translucent conductive electrode; (ii) an electrolyte solution in contact with the electrode, the electrolyte solution comprising metal cations that are reversibly electrodeposited onto the transparent electrode upon application of a cathodic potential; and (iii) a counter electrode. The electrolyte solution advantageously includes a small amount of an additive (e.g., an inhibitor, an accelerator, a leveler, or an organic or inorganic molecule that similarly serves to enhance the surface morphology of the metal cations during reversible metal electrodeposition onto the transparent electrode). Such enhancement of surface morphology during the reversible electrodeposition of the metal tinting layer over the electrode enhances one or more of color neutrality, transmittance characteristics of visible wavelengths (e.g., ability to achieve a near 0% transmission privacy state), infrared reflectance, or switching speed. |
| FILED | Wednesday, October 20, 2021 |
| APPL NO | 17/506170 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 17/10036 (20130101) B32B 17/10513 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 9/00 (20130101) Fixed or Movable Closures for Openings in Buildings, Vehicles, Fences or Like Enclosures in General, e.g Doors, Windows, Blinds, Gates E06B 9/24 (20130101) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/155 (20130101) G02F 1/1506 (20130101) Original (OR) Class G02F 1/13439 (20130101) G02F 2001/164 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129275 | Miniskar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| INVENTOR(S) | Narasinga Rao Miniskar (Oak Ridge, Tennessee); Frank Y. Liu (Oak Ridge, Tennessee); Jeffrey S. Vetter (Oak Ridge, Tennessee) |
| ABSTRACT | Methods and apparatus for managing circular queues are disclosed. A pointer designates an index position of a particular queue element and contains an additional pointer state, whereby two pointer values (split indexes) can designate the same index position. Front and rear pointers are respectively managed by dequeue and enqueue logic. The front pointer state and rear pointer state distinguish full and empty queue states when both pointers designate the same index position. Asynchronous dequeue and enqueue operations are supported, no lock is required, no queue entry is wasted. Hardware and software embodiments for numerous applications are disclosed. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500851 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/524 (20130101) G06F 9/546 (20130101) G06F 9/3009 (20130101) G06F 9/3814 (20130101) Original (OR) Class G06F 15/17375 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220130561 | ALESHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Yuriy ALESHIN (Cayce, South Carolina); Alex LEVINSKY (Pittsburgh, Pennsylvania); Matthew R. HEISEL (Pittsburgh, Pennsylvania); Stuart T. KELLNER (Pittsburgh, Pennsylvania) |
| ABSTRACT | A nuclear reactor is disclosed including a reactor core and a reflector assembly surrounding the reactor core. The reflector assembly includes a stationary reflector component including a graphite support structure comprising a plurality of channels defined therein and a plurality of beryllium-oxide pins positioned in the channels. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/080241 |
| CURRENT CPC | Nuclear Reactors G21C 3/18 (20130101) G21C 11/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220130621 | Shao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| ASSIGNEE(S) | RENSSELAER POLYTECHNIC INSTITUTE (Troy, New York) |
| INVENTOR(S) | Dali Shao (Mechanicville, New York); Shayla Maya Sawyer (Albany, New York); Jie Lian (Niskayuna, New York) |
| ABSTRACT | A hybrid fiber for detection of UV light is described. The hybrid fiber includes a conductor, a first layer, a photoactive layer, a second layer, and a transparent electrode. The conductor includes a conductive material. The first layer includes a first material deposited onto the conductor. The first material is configured to transport holes and block electrons. The photoactive layer includes a photoactive material coating the first layer. The photoactive material includes a first submaterial and a second submaterial. The second layer includes a second material deposited onto the photoactive layer. The second material is configured to block holes and transport electrons. The transparent electrode includes a transparent electrode material deposited onto the second layer. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/429822 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/429 (20130101) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 9/2009 (20130101) H01G 9/2086 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0071 (20130101) H01L 51/0077 (20130101) H01L 51/442 (20130101) H01L 51/4273 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131100 | Forrest et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R . Forrest (Ann Arbor, Michigan); Caleb COBURN (Ann Arbor, Michigan); Yue QU (Ann Arbor, Michigan) |
| ABSTRACT | An optoelectronic device comprises an anode, an emissive layer positioned over the anode, a charge generation layer stack positioned over the emissive layer, the charge generation layer stack comprising at least one hole transport layer and at least one electron transport layer positioned over the hole transport layer, and a cathode positioned over the charge generation layer stack. Other organic optoelectronic devices are also disclosed. |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496400 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0059 (20130101) H01L 51/5004 (20130101) Original (OR) Class H01L 51/5056 (20130101) H01L 51/5072 (20130101) H01L 51/5088 (20130101) H01L 51/5221 (20130101) H01L 51/5278 (20130101) H01L 2251/558 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131180 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland) |
| INVENTOR(S) | Chunsheng Wang (Silver Spring, Maryland); Chongyin YANG (College Park, Maryland); Jijian XU (Hyattsville, Maryland) |
| ABSTRACT | The disclosure provides rechargeable lithium ion batteries comprising at least one lithium salt-graphite composite electrode. In particular, the disclosure provides a rechargeable “water-in-bisalt” lithium ion battery with a high potential where at least a portion of the lithium salt is phase separated from the aqueous electrolyte, and where the anionic-redox reaction occurs within the graphitic lattice. |
| FILED | Friday, March 06, 2020 |
| APPL NO | 17/436609 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/043 (20130101) H01M 4/133 (20130101) H01M 4/364 (20130101) H01M 4/604 (20130101) H01M 4/623 (20130101) H01M 4/1393 (20130101) H01M 10/0525 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 2300/0085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131184 | Yu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Zhaoxin Yu (Richland, Washington); Dongping Lu (Richland, Washington); Jie Xiao (Richland, Washington); Jun Liu (Richland, Washington) |
| ABSTRACT | A method that includes contacting an amphipathic surface protective agent with a moisture sensitive Li-ion conductor material surface resulting in a protected Li-ion conductor material, and assembling an electrochemical cell that includes the protected Li-ion conductor material. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/507432 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/0562 (20130101) Original (OR) Class H01M 2300/0068 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131463 | GIULIANO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | David M. GIULIANO (Cambridge, Massachusetts); David J. PERREAULT (Cambridge, Massachusetts); Robert C.N. PILAWA-PODGURSKI (Cambridge, Massachusetts) |
| ABSTRACT | A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. The converter can be used, for example, to power logic devices in portable battery operated devices. |
| FILED | Friday, December 31, 2021 |
| APPL NO | 17/566750 |
| CURRENT CPC | Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 1/007 (20210501) H02M 3/07 (20130101) H02M 3/155 (20130101) H02M 3/158 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220131748 | Smith et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | UT-Battelle, LLC (Knoxville, Tennessee) |
| INVENTOR(S) | Jared M. Smith (Knoxville, Tennessee); Jordan A. Johnson (Knoxville, Tennessee); Brian Weber (Alexandria, Virginia); Christopher R. Hathhorn (Knoxville, Tennessee); Benjamin T. McDaniel (Deer Park, New York) |
| ABSTRACT | One or more virtual supervisory control and data acquisition (SCADA) controllers are provided. The virtual SCADA controller(s) may be deployed upon a detection of a failure of a physical SCADA controller. An on-site module may detect failure including a security breach which causes the physical SCADA controller to be disconnected from a network and the virtual SCADA controller(s) to take over control. The virtual SCADA controller(s) may be on-site or off-site. |
| FILED | Thursday, October 21, 2021 |
| APPL NO | 17/506969 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 41/082 (20130101) H04L 41/0668 (20130101) H04L 41/0695 (20130101) H04L 41/0816 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220126370 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jian Liu (Cary, North Carolina); Shuang Bai (Cary, North Carolina) |
| ASSIGNEE(S) | PolarOnyx, Inc. (Chapel Hill, North Carolina) |
| INVENTOR(S) | Jian Liu (Cary, North Carolina); Shuang Bai (Cary, North Carolina) |
| ABSTRACT | Methods and apparatuses for AM of all-in-one radiation shielding components from multi-material metal alloys, metal matrix, MMCs, and/or gradated compositions of the same are disclosed, comprising: providing an apparatus having: an energy source; a scanner; a powder system for powder(s); a powder delivery system; a shielding gas; and a computer coupled to and configured to control the energy source, scanner, powder system, and powder delivery system to deposit layers of the sample; programming the computer with specifications of the sample; using the computer to control electromagnetic radiation, mixing ratio, and powder deposition parameters based on the specifications of the sample; and using the autofocusing scanner to focus and scan the electromagnetic radiation onto the sample while the powders are concurrently deposited by the powder delivery system onto the sample to create a melting pool to deposit one or more layers onto the sample. Other embodiments are described and claimed. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511073 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/062 (20220101) B22F 1/065 (20220101) B22F 1/068 (20220101) B22F 10/36 (20210101) Original (OR) Class B22F 10/85 (20210101) B22F 12/30 (20210101) B22F 12/49 (20210101) B22F 12/58 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128004 | Muldoon et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| ASSIGNEE(S) | RAYTHEON TECHNOLOGIES CORPORATION (Farmington, Connecticut) |
| INVENTOR(S) | Marc J. Muldoon (Marlborough, Connecticut); Jonathan M. Rheaume (West Hartford, Connecticut) |
| ABSTRACT | The cooling system may comprise: an electric machine; a first conduit including a cable housing and an inlet; a plurality of conductive cables extending from the electric machine, the plurality of conductive cables disposed at least partially in the cable housing; and an electric fan disposed in the first conduit, the cooling system configured to passively flow air through the first conduit to cool the plurality of conductive cables during operation of the gas turbine engine, and the electric fan configured to actively cool the plurality of conductive cables after an engine shutdown of the gas turbine engine. |
| FILED | Tuesday, October 27, 2020 |
| APPL NO | 17/081627 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/12 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2260/20 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20145 (20130101) H05K 7/20209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129330 | Tan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bay Systems Consulting, Inc. (E. Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lujie Tan (Moffett Field, California); Sandeep Shetye (Moffett Field, California); Cuong Nguyen (Moffett Field, California); Ronald Instrella (Moffett Field, California); Jamie Vigliotta (Moffett Field, California); Mohana Gurram (Moffett Field, California); Jairon Moh Hashim (Moffett Field, California) |
| ABSTRACT | A data management platform for managing interconnected data and its derivatives is disclosed. For one example of the present disclosure, the data management platform receives data assets to a data management platform through an API gateway. The data assets are reformatted based upon a corresponding data model. A set of data management features are accessed through a corresponding API. The set of data management modules includes tagging, ownership, relationship, cataloging, discovery, lineage and provenance, and lifecycle. The management modules provide dynamic identification of interconnections between the data assets. Interconnections for the data assets are generated and the data assets and the interconnection data are stored based upon a format of the data. |
| FILED | Tuesday, October 27, 2020 |
| APPL NO | 17/081947 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/54 (20130101) Original (OR) Class G06F 16/22 (20190101) G06F 16/258 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129751 | Daftry et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Shreyansh Daftry (Pasadena, California); Annie K. Didier (Pasadena, California); Deegan J. Atha (Pasadena, California); Masahiro Ono (Pasadena, California); Chris A. Mattmann (Pasadena, California); Zhanlin Chen (Pasadena, California) |
| ABSTRACT | A computer implemented system for interpreting data using machine learning, including one or more processors; one or more memories; and one or more computer executable instructions embedded on the one or more memories, wherein the computer executable instructions are configured to execute a unified encoder comprising a neural network encoding data into one or more feature vectors, wherein the encoder is trained using machine learning to generate the one or more feature vectors useful for performing a plurality of different tasks each comprising different interpretations of the data. A plurality of decoders are connected to the unified encoder, each of the decoders comprising a neural network interpreting the one or more feature vectors so as to decode one or more of the feature vectors to output one of the interpretations. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509926 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Original (OR) Class G06N 3/0481 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220125071 | Thavarajah et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Clemson University Research Foundation (Clemson, South Carolina) |
| ASSIGNEE(S) | Clemson University (Clemson, South Carolina) |
| INVENTOR(S) | Dilrukshi Thavarajah (Pendleton, South Carolina); Pushparajah Thavarajah (Pendleton, South Carolina) |
| ABSTRACT | Disclosed herein are various organic plant protein compositions including a balanced amino acid profile with no chemical residues. Further disclosed herein are methods for creating organic plant protein compositions from organic plant material(s). In some embodiments, the organic plant protein composition includes pea protein, sorghum protein, organic baking powder, and organic vinegar. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512136 |
| CURRENT CPC | Protein Compositions for Foodstuffs; Working-up Proteins for Foodstuffs; Phosphatide Compositions for Foodstuffs A23J 1/12 (20130101) A23J 1/14 (20130101) Original (OR) Class Separation B01D 21/262 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127561 | Dardick et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by The Secretary of Agricalture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher D. Dardick (Shenandoah Junction, West Virginia); Wojciech J. Janisiewicz (Frederick, Maryland); Zongrang Liu (Winchester, Virginia); Zhijian Li (Martinsburg, West Virginia); Ann M. Callahan (Shepherdstown, West Virginia) |
| ABSTRACT | Cladosporium sphaerospermum produces at least one volatile organic compound (VOC). When a plant is exposed to the VOC produced by a strain of C. sphaerospermum, the plant has an increase in at least one growth characteristic compared to the growth characteristic of an untreated plant of the same age as the treated plant. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570596 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 9/02 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 27/00 (20130101) A01N 63/30 (20200101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) C12N 1/145 (20210501) Original (OR) Class Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/002 (20130101) Indexing Scheme Associated With Subclasses C12C - C12Q, Relating to Microorganisms C12R 2001/645 (20210501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128514 | SALLOUM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| INVENTOR(S) | Hady SALLOUM (Cedar Grove, New Jersey); Alexander SEDUNOV (Jersey City, New Jersey); Nikolay Sedunov (Jersey City, New Jersey); Alexander SUTIN (Summit, New Jersey); Alexander Yakubovskiy (Providence, Rhode Island) |
| ABSTRACT | Embodiments of the invention include a system and method for detecting wood-boring species of insects in a structure (16), involving one or more primary (14) and reference (18) sensors and a signal conditioning and acquisition device (22) capable of being coupled to the sensors (14, 18). The system (10) also includes a processor (24) capable of being coupled to a non-transitory, computer-readable storage medium that includes program logic for execution by the processor (24). The program logic includes a logic module that receives signals originating from the sensors (14, 18) and discriminates between noise generated by any wood boring species in the structure and extraneous noise unrelated to the wood boring species of insects. The extraction of signal features based on pulse duration, signal spectra and signal envelope spectra can be used for insect pulse discrimination. A sound-suppressing sensor assembly (12) can be weighted to enhance the coupling of the primary sensor (14) with the structure (16) being tested. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/429925 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/004 (20130101) G01H 11/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/14 (20130101) Original (OR) Class G01N 29/32 (20130101) G01N 29/2418 (20130101) G01N 29/2437 (20130101) G01N 29/4436 (20130101) G01N 29/4454 (20130101) G01N 29/4463 (20130101) G01N 2291/0238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220126268 | Weston et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NuMat Technologies Inc. (Skokie, Illinois) |
| ASSIGNEE(S) | NuMat Technologies Inc. (Skokie, Illinois) |
| INVENTOR(S) | Mitchell Hugh Weston (Chicago, Illinois); Edwin Alfonso Argueta Fajardo (Chicago, Illinois) |
| ABSTRACT | This invention relates to a Cu-BTC MOF which is water stable. The Cu-BTC MOF has been modified by substituting some of the BTC ligand (1,3,5, benzene tricarboxylic acid) with 5-aminoisophthalic acid (AIA). The resultant MOF retains at least 40% of its as synthesized surface area after exposure to liquid water at 60° C. for 6 hours. This is an unexpected result versus the MOF containing only the BTC ligand. This MOF can be used to abate contaminants such as ammonia in gas streams and especially air streams. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571073 |
| CURRENT CPC | Separation B01D 53/58 (20130101) B01D 53/82 (20130101) B01D 53/8634 (20130101) B01D 2253/204 (20130101) B01D 2255/705 (20130101) B01D 2255/9207 (20130101) B01D 2257/406 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/3085 (20130101) B01J 20/28016 (20130101) B01J 20/28019 (20130101) B01J 20/28038 (20130101) B01J 20/28045 (20130101) B01J 20/28066 (20130101) B01J 20/28073 (20130101) B01J 31/1691 (20130101) B01J 35/04 (20130101) B01J 35/08 (20130101) B01J 35/026 (20130101) B01J 35/1028 (20130101) B01J 37/04 (20130101) B01J 37/10 (20130101) B01J 2231/005 (20130101) B01J 2531/16 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 1/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128514 | SALLOUM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| ASSIGNEE(S) | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (Hoboken, New Jersey) |
| INVENTOR(S) | Hady SALLOUM (Cedar Grove, New Jersey); Alexander SEDUNOV (Jersey City, New Jersey); Nikolay Sedunov (Jersey City, New Jersey); Alexander SUTIN (Summit, New Jersey); Alexander Yakubovskiy (Providence, Rhode Island) |
| ABSTRACT | Embodiments of the invention include a system and method for detecting wood-boring species of insects in a structure (16), involving one or more primary (14) and reference (18) sensors and a signal conditioning and acquisition device (22) capable of being coupled to the sensors (14, 18). The system (10) also includes a processor (24) capable of being coupled to a non-transitory, computer-readable storage medium that includes program logic for execution by the processor (24). The program logic includes a logic module that receives signals originating from the sensors (14, 18) and discriminates between noise generated by any wood boring species in the structure and extraneous noise unrelated to the wood boring species of insects. The extraction of signal features based on pulse duration, signal spectra and signal envelope spectra can be used for insect pulse discrimination. A sound-suppressing sensor assembly (12) can be weighted to enhance the coupling of the primary sensor (14) with the structure (16) being tested. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/429925 |
| CURRENT CPC | Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 9/004 (20130101) G01H 11/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/14 (20130101) Original (OR) Class G01N 29/32 (20130101) G01N 29/2418 (20130101) G01N 29/2437 (20130101) G01N 29/4436 (20130101) G01N 29/4454 (20130101) G01N 29/4463 (20130101) G01N 2291/0238 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220130494 | Woodbury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Neal W. Woodbury (Tempe, Arizona); Alexander T. Taguchi (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Neal W. Woodbury (Tempe, Arizona); Alexander T. Taguchi (Cambridge, Massachusetts) |
| ABSTRACT | Mechanisms for molecule design using machine learning include: forming a first training set for a neural network using, for each of a first plurality of known molecules, a plurality of input values that represent the structure of the known molecule and a plurality of functional property values for the known molecule; training the neural network using the first training set; proposing a first plurality of proposed molecules, and predicting first predicted functional property values of the first plurality of proposed molecules that have the desired function property values; causing the first plurality of proposed molecules to be synthesized to form a first plurality of synthesized molecules; receiving first measured functional property values of the first plurality of synthesized molecules; and adding data regarding the first plurality of synthesized molecules to the first training set to form a second training set and retrain the neural network using the second training set. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/427786 |
| CURRENT CPC | Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/10 (20190201) G16B 40/20 (20190201) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 20/50 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220125426 | Khanicheh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | EnVision Endoscopy, Inc. (Somerville, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Azadeh Khanicheh (Somerville, Massachusetts); Amos Cruz (Wrentham, Massachusetts) |
| ABSTRACT | A method cinches a suture. The method provides a cinch having a suture capturing portion configured to capture a suture, a cinch lock coupled with the suture capturing portion, and a cinch anchor having a lumen. The suture capturing portion is extended out of the lumen to capture the suture. The suture is captured by the suture capturing portion. The suture capturing portion is retracted into the lumen of the cinch anchor. The suture is cinched between the cinch lock and the cinch anchor. |
| FILED | Saturday, October 23, 2021 |
| APPL NO | 17/508989 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/018 (20130101) A61B 17/0469 (20130101) A61B 17/0485 (20130101) A61B 17/0487 (20130101) Original (OR) Class A61B 2017/00358 (20130101) A61B 2017/0488 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220126370 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Jian Liu (Cary, North Carolina); Shuang Bai (Cary, North Carolina) |
| ASSIGNEE(S) | PolarOnyx, Inc. (Chapel Hill, North Carolina) |
| INVENTOR(S) | Jian Liu (Cary, North Carolina); Shuang Bai (Cary, North Carolina) |
| ABSTRACT | Methods and apparatuses for AM of all-in-one radiation shielding components from multi-material metal alloys, metal matrix, MMCs, and/or gradated compositions of the same are disclosed, comprising: providing an apparatus having: an energy source; a scanner; a powder system for powder(s); a powder delivery system; a shielding gas; and a computer coupled to and configured to control the energy source, scanner, powder system, and powder delivery system to deposit layers of the sample; programming the computer with specifications of the sample; using the computer to control electromagnetic radiation, mixing ratio, and powder deposition parameters based on the specifications of the sample; and using the autofocusing scanner to focus and scan the electromagnetic radiation onto the sample while the powders are concurrently deposited by the powder delivery system onto the sample to create a melting pool to deposit one or more layers onto the sample. Other embodiments are described and claimed. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/511073 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/062 (20220101) B22F 1/065 (20220101) B22F 1/068 (20220101) B22F 10/36 (20210101) Original (OR) Class B22F 10/85 (20210101) B22F 12/30 (20210101) B22F 12/49 (20210101) B22F 12/58 (20210101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129425 | Daimler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Conexus ai, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Alexander Daimler (San Francisco, California); Ryan Jacob Wisnesky (San Francisco, California); David Isaac Spivak (Somerville, Massachusetts) |
| ABSTRACT | A data migration and integration system is disclosed. In various embodiments, the system includes a memory configured to store a mapping from a source schema to a target schema; and a processor coupled to the memory and configured to migrate to a target schema an instance of source data organized according to the source schema, including by using a chase engine to perform an ordered sequence of steps comprising adding a bounded layer of new elements to a current canonical chase state associated with migrating the source data to the target schema; adding coincidences associated with one or more of the target schema data integrity constraints and a mapping from the source schema to the target schema; and merging equal elements based on the coincidences; and repeat the preceding ordered sequence of steps iteratively until an end condition is met. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/571939 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/86 (20190101) G06F 16/182 (20190101) G06F 16/211 (20190101) G06F 16/214 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220128357 | HORVAT |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITYCORPORATION FOR ATMOSPHERIC RESEARCH (Boulder, Colorado) |
| ASSIGNEE(S) | UNIVERSITYCORPORATION FOR ATMOSPHERIC RESEARCH (Boulder, Colorado) |
| INVENTOR(S) | Christopher HORVAT (Providence, Rhode Island) |
| ABSTRACT | A method (100) and system (500) for determining a floe size distribution (350), (516) for a plurality of floes within a geographical area (204), comprising determining a chord length distribution (512) for the geographical area (204), the chord length distribution (512) comprising a plurality of measured floe chord lengths, and determining the floe size distribution (350, 516) over the geographical area (204) based on the chord length distribution (512), the floe size distribution (350, 516) comprising a plurality of floe diameters (402). |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/429084 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 13/00 (20130101) Original (OR) Class G01C 21/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220129425 | Daimler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Conexus ai, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Alexander Daimler (San Francisco, California); Ryan Jacob Wisnesky (San Francisco, California); David Isaac Spivak (Somerville, Massachusetts) |
| ABSTRACT | A data migration and integration system is disclosed. In various embodiments, the system includes a memory configured to store a mapping from a source schema to a target schema; and a processor coupled to the memory and configured to migrate to a target schema an instance of source data organized according to the source schema, including by using a chase engine to perform an ordered sequence of steps comprising adding a bounded layer of new elements to a current canonical chase state associated with migrating the source data to the target schema; adding coincidences associated with one or more of the target schema data integrity constraints and a mapping from the source schema to the target schema; and merging equal elements based on the coincidences; and repeat the preceding ordered sequence of steps iteratively until an end condition is met. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/571939 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/86 (20190101) G06F 16/182 (20190101) G06F 16/211 (20190101) G06F 16/214 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220127975 | Tillman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| ASSIGNEE(S) | HONEYWELL INTERNATIONAL INC. (Charlotte, North Carolina) |
| INVENTOR(S) | Donald Tillman (Phoenix, Arizona); Ryon James Stanley (Phoenix, Arizona); Courtney Murphy (Phoenix, Arizona) |
| ABSTRACT | A system for coupling a shroud to a case associated with a gas turbine engine and a gas turbine engine including such a system includes the case defining a bore and the shroud retained within the case. The shroud defines a pocket. The system includes a pin received through the bore and at least partially positioned within the pocket. The pin has a perimeter. The system includes a load spreader including a first side and a second side opposite the first side. The first side is interconnected to the second side by a flexible portion. The first side, the second side and the flexible portion are received about a portion of the perimeter of the pin, and the load spreader is configured to transmit at least one of an axial point load and a circumferential point load from the pin over a surface of the shroud. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/077079 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 9/04 (20130101) F01D 11/18 (20130101) F01D 25/246 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/32 (20130101) F05D 2240/12 (20130101) F05D 2240/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20220128547 | Wiktor et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Ariz (Scottsdale, Arizona); Engineering Arts LLC (Phoenix, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Wiktor (Phoenix, Arizona); Joshua Labaer (Chandler, Arizona); Peter Kahn (Phoenix, Arizona); Bharath Takulapalli (Tempe, Arizona); Ji Qiu (Chandler, Arizona); Al Brunner (Phoenix, Arizona); Mitch Magee (Chandler, Arizona) |
| ABSTRACT | Biomolecule arrays on a substrate are described which contain a plurality of biomolecules, such as coding nucleic acids and/or isolated polypeptides, at a plurality of discrete, isolated, locations. The arrays can be used, for example, in high throughput genomics and proteomics for specific uses including, but not limited molecular diagnostics for early detection, diagnosis, treatment, prognosis, monitoring clinical response, and protein crystallography. |
| FILED | Wednesday, June 02, 2021 |
| APPL NO | 17/337274 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/0046 (20130101) B01J 2219/00317 (20130101) B01J 2219/00596 (20130101) B01J 2219/00608 (20130101) B01J 2219/00612 (20130101) B01J 2219/00621 (20130101) B01J 2219/00626 (20130101) B01J 2219/00637 (20130101) B01J 2219/00659 (20130101) B01J 2219/00722 (20130101) B01J 2219/00725 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1079 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 50/14 (20130101) C40B 60/12 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/543 (20130101) Original (OR) Class G01N 33/6845 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220126148 | Hansson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alden Research Laboratory, Inc. (Holden, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James B. Hansson (Holden, Massachusetts); Kimbal A. Hall (Princeton, Massachusetts); Daniel Bateman (Rutland, Massachusetts); David C. White (Providence, Rhode Island) |
| ABSTRACT | A nozzle for dispensing a fluid having a barrel having a proximal end and a distal end, the barrel having a passage defined by a first internal surface extending between the distal end and the proximal end, and an orifice defined by a second internal surface at the distal end of the barrel, a stem located at least partially in the barrel, the barrel is movable in relation to the stem to switch between a low pressure mode and a high pressure mode, a shaper located around an outer surface of the distal end of the barrel, the shaper being movable in relation to the barrel to switch between a low pressure fog mode and a low pressure stream mode. The nozzle is configured to dispense the fluid in a straight stream or fog in both the low pressure mode and the ultra-high pressure mode. The orifice is also configured to provide flushing capability for the ultra-high pressure mode while operating in the low pressure mode. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/080220 |
| CURRENT CPC | Fire-fighting A62C 31/03 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220127967 | Radwanski et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | General Electric Company (Schenectady, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Todd Radwanski (Newport, Kentucky); Darrell Glenn Senile (Oxford, Ohio) |
| ABSTRACT | A sealing assembly for a gas turbine engine. The sealing assembly includes first and second gas turbine walls defining a channel therebetween. Additionally, the second gas turbine wall further defines a passage extending therethrough. Furthermore, the sealing assembly includes a leaf seal partially positioned within the channel and a seal holder coupled to the second gas turbine wall. Moreover, the sealing assembly includes a spring compressed between the seal holder and the leaf seal such that the leaf seal is in sealing engagement with the first gas turbine wall. In addition, the sealing assembly includes a pin extending through the passage defined by the second gas turbine wall to couple the seal holder and the leaf seal such that the pin is thermally unconstrained by the second wall during operation of the gas turbine engine. |
| FILED | Monday, October 26, 2020 |
| APPL NO | 17/079893 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 11/001 (20130101) F01D 11/005 (20130101) Original (OR) Class Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/28 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2220/323 (20130101) F05D 2240/35 (20130101) F05D 2240/57 (20130101) F05D 2260/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220128362 | Krueger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| ASSIGNEE(S) | Honeywell International Inc. (Charlotte, North Carolina) |
| INVENTOR(S) | Neil A. Krueger (Saint Paul, Minnesota); Glen A. Sanders (Scottsdale, Arizona); Lee K. Strandjord (Tonka Bay, Minnesota); Marc Smiciklas (Phoenix, Arizona) |
| ABSTRACT | Improvements to optical power regulation in a gyroscopic system are described. The system can include an optical assembly (e.g., optical bench) which couples opposing optical signals to a resonator coil. The system can monitor the power of the optical signals through the resonator coil by including signal extraction optics in the optical assembly which are configured to extract a portion of the optical signals. The portions can be extracted via a single beamsplitter, wherein the beamsplitter reflects the portions at a single common surface, and can also reflect the portions to a respective photodetector in free space free from intervening optical components, such as polarizers or beamplitters. One or more processors can be coupled to the optical assembly, wherein the processor(s) are configured to adjust the power of the optical signals in response to detecting a power difference between the optical signals. |
| FILED | Thursday, October 22, 2020 |
| APPL NO | 17/077192 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/661 (20130101) G01C 19/722 (20130101) G01C 19/727 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, April 28, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
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THE PANEL
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FUNDED BY
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Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
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Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
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FILED
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3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
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CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
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