FedInvent™ Patent Applications

Application Details for Thursday, May 05, 2022 

This page was updated on Sunday, May 08, 2022 at 03:42 PM GMT

Department of Health and Human Services (HHS) 

US 20220133139 Mahadevan-Jansen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Anita Mahadevan-Jansen (Nashville, Tennessee);  Giju Thomas (Nashville, Tennessee);  Kamran Idrees (Nashville, Tennessee);  Carmen Solorzano (Nashville, Tennessee);  Parker Willmon (Nashville, Tennessee);  Colleen Kiernan (Nashville, Tennessee)
ABSTRACT The invention discloses systems and methods for providing anatomical guidance in surgery. The system includes a light source configured to emit light for illuminating tissues of a target region; means for obtaining autofluorescence signals emitted from the illuminated tissues in response to the illumination; and a controller configured to process the obtained autofluorescence signal to identify target tissues.
FILED Monday, November 01, 2021
APPL NO 17/515748
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 1/0005 (20130101)
A61B 1/07 (20130101)
A61B 1/042 (20130101)
A61B 1/063 (20130101)
A61B 1/0638 (20130101) Original (OR) Class
A61B 1/0646 (20130101)
A61B 1/0684 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133159 Ansari et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Sardar Ansari (Ypsilanti, Michigan);  Kenn Oldham (Ann Arbor, Michigan);  Kevin R. Ward (Superior Township, Michigan);  Kayvan Najarian (Northville, Michigan);  Lu Wang (Ann Arbor, Michigan)
ABSTRACT A method for noninvasively measuring hemodynamic variables of a person includes physically configuring a sensor to measure the pulse of a person. The sensor generates a pulse waveform indicative of the pulse of the person. A processor obtains the pulse waveform from the sensor and the processor determines a reflection coefficient and reflection delay between an incident and a reflected wave, from which the processor determines the hemodynamic variables of the person from the reflection coefficient and the reflection delay.
FILED Friday, October 29, 2021
APPL NO 17/514939
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/02116 (20130101) Original (OR) Class
A61B 5/02125 (20130101)
A61B 5/6819 (20130101)
A61B 5/6822 (20130101)
A61B 5/6823 (20130101)
A61B 5/6824 (20130101)
A61B 5/6826 (20130101)
A61B 5/6828 (20130101)
A61B 5/6829 (20130101)
A61B 5/6831 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133167 Barlow et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Innara Health, Inc. (Olathe, Kansas)
ASSIGNEE(S) Innara Health, Inc. (Olathe, Kansas);  University of Kansas (Lawrence, Kansas)
INVENTOR(S) Steven M. Barlow (Lawrence, Kansas);  David L. Stalling (Olathe, Kansas);  Kenneth Aron (Olathe, Kansas)
ABSTRACT The present invention relates to methods of using a therapeutic system. In particular, the present invention relates to procedures and methods of using a system having hardware, software, and appliance components for assessing and entraining a non-nutritive suck (NNS) pattern in a patient. The methods include configuring the hardware and software systems to receive data from an orofacial stimulation appliance and to generate a precise therapeutic pulse profile that is actuated as a tactile stimulus. The methods also include collecting data using the orofacial stimulation appliance and delivering the tactile stimulus via the orofacial stimulation appliance to entrain an organized NNS pattern.
FILED Friday, January 14, 2022
APPL NO 17/576745
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/038 (20130101) Original (OR) Class
A61B 5/486 (20130101)
A61B 5/682 (20130101)
A61B 5/6896 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133181 Beni et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Washington (Seattle, Washington)
ASSIGNEE(S)
INVENTOR(S) Catherine Beni (Seattle, Washington);  Barclay Stewart (Seattle, Washington);  Jonathan Dov Posner (Seattle, Washington);  Aman Garg (Seattle, Washington);  Nelson Warner (Seattle, Washington);  Kenneth Shim (Seattle, Washington);  Yuan-Ni Yeh (Seattle, Washington)
ABSTRACT Systems, devices, and methods to measure interstitial concentration of selected compounds over time to provide early detection of shock are described. In an example method, interstitial fluid is obtained from a subject. Analytes are detected in the interstitial fluid. At least one of the analytes corresponds to hypoxia of a tissue of the subject and at least one other analyte corresponds to vascular permeability of the subject. The example method further includes determining whether the subject is in shock based on a computing model and the detected analytes and generating an alert based on whether the subject is in shock. Treatments can be administered following the alert generation.
FILED Friday, October 29, 2021
APPL NO 17/514941
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/0004 (20130101)
A61B 5/7282 (20130101)
A61B 5/14514 (20130101) Original (OR) Class
A61B 5/14546 (20130101)
A61B 5/14735 (20130101)
A61B 2010/008 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6893 (20130101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/40 (20180101)
G16H 40/67 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133205 Efimov et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Washington University (St. Louis, Missouri)
ASSIGNEE(S) Washington University (St. Louis, Missouri)
INVENTOR(S) Igor R. Efimov (Arlington, Virginia);  Valentin I. Krinski (Villeneuve Loubet, France);  Vladmir P. Nikolski (St. Anthony, Minnesota)
ABSTRACT A method for extinguishing a cardiac arrhythmia utilizes destructive interference of the passing of the reentry wave tip of an anatomical reentry through a depolarized region created by a relatively low voltage electric field in such a way as to effectively unpin the anatomical reentry. Preferably, the relatively low voltage electric field is defined by at least one unpinning shock(s) that are lower than an expected lower limit of vulnerability as established, for example, by a defibrillation threshold test. By understanding the physics of the electric field distribution between cardiac cells, the method permits the delivery of an electric field sufficient to unpin the core of the anatomical reentry, whether the precise or estimated location of the reentry is known or unknown and without the risk of inducting ventricular fibrillation. A number of embodiments for performing the method are disclosed.
FILED Monday, November 15, 2021
APPL NO 17/454886
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/318 (20210101) Original (OR) Class
A61B 5/363 (20210101)
A61B 5/7239 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 1/3627 (20130101)
A61N 1/3906 (20130101)
A61N 1/3925 (20130101)
A61N 1/3987 (20130101)
A61N 1/39622 (20170801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133273 DANGI et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
APPLICANT(S) The Penn State Research Foundation (University Park, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Ajay DANGI (University Park, Pennsylvania);  Sumit AGRAWAL (University Park, Pennsylvania);  Sri-Rajasekhar KOTHAPALLI (University Park, Pennsylvania)
ABSTRACT The present disclosure provides photoacoustic-imaging techniques using an optically-transparent bulk piezoelectric ultrasound transducer. A PAI system is disclosed. The PAI system has an optically translucent piezoelectric substrate, and a light source capable of providing light through the transducer to a region of interest.
FILED Tuesday, February 11, 2020
APPL NO 17/429453
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 8/4416 (20130101)
A61B 8/4444 (20130101)
A61B 8/4483 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133474 Bui et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) Ohio State Innovation Foundation (Columbus, Ohio);  Georgia Institute of Technology (Atlanta, Georgia);  Colorado State University Research Foundation (Fort Collins, Colorado)
ASSIGNEE(S) Ohio State Innovation Foundation (Columbus, Ohio);  Georgia Institute of Technology (Atlanta, Georgia);  Colorado State University Research Foundation (Fort Collins, Colorado)
INVENTOR(S) Hieu Bui (Lithia Springs, Georgia);  Lakshmi Prasad Dasi (Dublin, Ohio);  Megan Heitkemper (San Jose, California);  Susan James (Bellvue, Colorado);  Nipa Khair (Fort Collins, Colorado)
ABSTRACT A transcatheter prosthetic heart valve includes a stent frame and a leaflet material. The stent frame includes a top portion and a bottom portion. The leaflet material includes a lower portion attached to the stent frame and an upper portion that includes leaflets capable of moving between an open configuration and a closed configuration. At least a portion of the leaflet material weaves through the stent frame. The transcatheter prosthetic heart valve also includes one or more reinforcement components coupled to the stent frame and/or to the leaflet material to enhance performance of the transcatheter heart valve.
FILED Friday, January 14, 2022
APPL NO 17/648076
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/2415 (20130101)
A61F 2/2418 (20130101) Original (OR) Class
A61F 2/2433 (20130101)
A61F 2210/0004 (20130101)
A61F 2240/001 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133509 Segil et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) The Regents of the University of Colorado, a body corporate (Denver, Colorado);  Point Designs LLC (Lafayette, Colorado)
ASSIGNEE(S)
INVENTOR(S) Jacob Segil (Boulder, Colorado);  Stephen Huddle (Thornton, Colorado);  Levin Sliker (Boulder, Colorado);  Richard Weir (Lafayette, Colorado)
ABSTRACT Various embodiments of the present invention generally relate to prosthetic partial finger designs that can mimic the last two joints of the finger. Some embodiments include a proximal phalange, a distal phalange coupled to the proximal phalange, and a knuckle track (e.g., formed in an arc). The knuckle track can be moveably coupled to the proximal phalange an may include multiple teeth formed on which the proximal phalange slides along. A ratcheting mechanism can contact the multiple teeth to allow sliding in only a first direction while the ratcheting mechanism is engaged. Some embodiments include a release mechanism (e.g., a button) configured to disengage the ratcheting mechanism from the multiple teeth to allow the distal phalange to slide in a second direction. In some embodiments, the device may include a spring-back capability that automatically extends the finger after reaching full finger flexion, enabling one-handed use.
FILED Monday, January 10, 2022
APPL NO 17/571773
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 2/66 (20130101)
A61F 2/72 (20130101)
A61F 2/586 (20130101) Original (OR) Class
A61F 2/5046 (20130101)
A61F 2002/587 (20130101)
A61F 2002/5038 (20130101)
A61F 2002/5056 (20130101)
A61F 2002/5072 (20130101)
A61F 2002/6621 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 80/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133519 Lerner et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Child Health and Human Development (NICHD)
APPLICANT(S) Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona)
ASSIGNEE(S)
INVENTOR(S) Zachary F Lerner (Flagstaff, Arizona);  Grigoriy Orekhov (Flagstaff, Arizona);  Leah Liebelt (Flagstaff, Arizona)
ABSTRACT An assistive ankle foot orthosis is described. The AFO has a tubular vertical member arranged laterally to a user's limb. The member carries a rotational bearing and a rotational element such as a pulley. The pulley is connected to a footplate. The footplate provides joint movement assistance or resistance to the user upon rotation of the pulley. The pulley is coupled to one or more springs that provide counter-rotational resistance to pulley movement, thereby storing, and then returning, rotational force during certain foot movements. The spring can include a leaf spring arranged inside the member, the stiffness of which can be manually, automatically or dynamically adjusted by movement of the device.
FILED Friday, October 29, 2021
APPL NO 17/515300
CURRENT CPC
Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits
A61F 5/0127 (20130101) Original (OR) Class
A61F 2005/0155 (20130101)
A61F 2005/0167 (20130101)
A61F 2005/0179 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133637 CHENG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Board of Regents of The University of Texas System (Austin, Texas)
ASSIGNEE(S) The Board of Regents of The University of Texas System (Austin, Texas)
INVENTOR(S) Qiang CHENG (Dallas, Texas);  Tuo WEI (Dallas, Texas);  Daniel J. SIEGWART (Dallas, Texas)
ABSTRACT The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
FILED Monday, January 10, 2022
APPL NO 17/572615
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5123 (20130101) Original (OR) Class
A61K 48/0033 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/11 (20130101)
C12N 15/111 (20130101)
C12N 15/113 (20130101)
C12N 2310/20 (20170501)
C12N 2320/32 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133639 Thayumanavan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E)
National Security Engineering Center (NSEC)
Federally Funded Research and Development Center (FFRDC)
Operated by MITRE Corporation (MITRE) at Bedford, MA
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
Division of Materials Research (DMR)
Nanoscale Science and Engineering Centers (NSF-NSEC)
APPLICANT(S) University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Sankaran Thayumanavan (Amherst, Massachusetts);  Jiaming Zhuang (Amherst, Massachusetts);  Hui Wang (Sunderland, Massachusetts)
ABSTRACT The invention generally relates to polymer-based nano-structures. More particularly, the invention relates to novel, surface-functionalized, guest-host polymer nano-assemblies and nano-delivery vehicles useful in diverse fields including drug delivery, diagnostics and specialty materials. The nano-assemblies and nano-delivery vehicles of the invention are afforded via simplify and reliable approaches.
FILED Saturday, July 31, 2021
APPL NO 17/390912
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5138 (20130101) Original (OR) Class
A61K 9/5146 (20130101)
A61K 47/6903 (20170801)

Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests
Y10S 977/773 (20130101)
Y10S 977/906 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133671 Gomer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Texas A and M University System (College Station, Texas)
ASSIGNEE(S) The Texas A and M University System (College Station, Texas)
INVENTOR(S) Richard H. Gomer (College Station, Texas);  Thomas Meek (College Station, Texas);  Tejas Karhadkar (College Station, Texas);  Darrell Pilling (Cypress, Texas)
ABSTRACT The present disclosure relates to methods of preventing or inhibiting fibrosis using small molecule sialidase inhibitors. The present disclosure also relates to methods treating obesity, liver inflammation, steatosis, and cancer. These methods can involve administering the compounds to a patent at risk of developing fibrosis inflammation, obesity, steatosis, or cancer, in a manner that inhibits NEU3.
FILED Monday, February 10, 2020
APPL NO 17/430287
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/55 (20130101)
A61K 31/60 (20130101)
A61K 31/215 (20130101) Original (OR) Class
A61K 31/351 (20130101)
A61K 31/401 (20130101)
A61K 31/445 (20130101)
A61K 31/455 (20130101)
A61K 31/4402 (20130101)
A61K 31/4406 (20130101)
A61K 31/4422 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133672 Blatt et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Julie M. Blatt (Chapel HI!!, North Carolina);  Reema B. Davis (Apex, North Carolina);  Kristy Pahl (Chapel Hill, North Carolina);  Kathleen Marie-lsabelle Caron (Chapel Hill, North Carolina);  Scott Victor Smith (Cary, North Carolina);  Carrie J. Shawber (Township of Washington, North Carolina)
ABSTRACT The present disclosure provides a method to treat or ameliorate vascular malformations, developmental abnormalities of one or more types of blood or lymphatic vessels. These are rare disorders with life-long risk of high morbidity including cosmetic concerns, pain, infection, pulmonary emboli, bleeding and even death. Treatment is difficult, and there is growing interest in improved therapies. The disclosure provides specific compounds that are inhibitors of Notch receptor signaling. In some embodiments, the compounds disclosed are gamma secretase inhibitors (GSIs).
FILED Wednesday, December 18, 2019
APPL NO 17/415813
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/55 (20130101)
A61K 31/216 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 9/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133706 MISCHEL et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California);  LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (Zurich, Switzerland)
ASSIGNEE(S)
INVENTOR(S) Paul S. MISCHEL (La Jolla, California);  Bing REN (Del Mar, California);  Vineet BAFNA (San Diego, California);  Sudhir CHOWDHRY (San Diego, California)
ABSTRACT There are provided, inter alia, methods for treatment of cancer. The methods include means of identifying the NAD biosynthetic pathway on which depend cancer cells in a tumor, in a subject suffering from cancer. The methods further include administering to a subject in need a therapeutically effective amount of an inhibitor of the NMRK1 enzyme pathway to a tumor where the cancer cells are dependent of the NAD salvage pathway, allowing to lower the of dose FK866 administered to the subject. The methods also include administering to a subject in need a therapeutically effective amount of a bacterial inhibitor of NADSYN1 to a tumor where the cancer cells depend on the Preiss Handler pathway.
FILED Friday, March 13, 2020
APPL NO 17/438610
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/63 (20130101)
A61K 31/455 (20130101)
A61K 31/4545 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133713 Canney et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Daniel J. Canney (Ambler, Pennsylvania);  Benjamin E. Blass (Eagleville, Pennsylvania);  Rong Gao (Roscoe, Illinois);  Kevin Blattner (Folsom, Pennsylvania)
ABSTRACT Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.
FILED Monday, June 14, 2021
APPL NO 17/347253
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/496 (20130101) Original (OR) Class
A61K 31/4525 (20130101)
A61K 31/4709 (20130101)
A61K 31/4725 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Heterocyclic Compounds
C07D 307/33 (20130101)
C07D 307/94 (20130101)
C07D 405/02 (20130101)
C07D 405/06 (20130101)
C07D 405/12 (20130101)
C07D 405/14 (20130101)
C07D 413/12 (20130101)
C07D 417/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133715 TYNER et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon)
ASSIGNEE(S) OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon)
INVENTOR(S) JEFFREY TYNER (Portland, Oregon);  TAMILLA NECHIPORUK (Portland, Oregon);  STEPHEN KURTZ (Portland, Oregon);  SHANNON MCWEENY (Portland, Oregon)
ABSTRACT The present invention concerns novel methods of treatment for venetoclax-resistant acute myeloid leukemia, particularly in subjects with a low expression of TP53 protein or expression of TP53 protein associated with a mutation of the TP53 gene, the methods comprising administering to the subject in need thereof a therapeutically effective amount of a NTRK/ALK/ROS1 inhibitor, or a pharmaceutically acceptable salt thereof.
FILED Wednesday, February 26, 2020
APPL NO 17/434278
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/437 (20130101)
A61K 31/496 (20130101) Original (OR) Class
A61K 31/506 (20130101)
A61K 31/635 (20130101)
A61K 31/4545 (20130101)
A61K 31/5377 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/02 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133730 Zuo et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Ting Therapeutics LLC (Omaha, Nebraska)
ASSIGNEE(S) Ting Therapeutics LLC (Omaha, Nebraska)
INVENTOR(S) Jian Zuo (Omaha, Nebraska);  Tal Teitz (Omaha, Nebraska)
ABSTRACT Method, kit and pharmaceutical compositions using an inhibitor of EGFR signaling for prevention or treatment of hearing loss are described.
FILED Friday, January 21, 2022
APPL NO 17/580755
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/437 (20130101)
A61K 31/506 (20130101)
A61K 31/519 (20130101) Original (OR) Class
A61K 31/4439 (20130101)
A61K 31/4709 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133746 PAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The University of Chicago (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Deng PAN (Chicago, Illinois);  Masha KOCHERGINSKY (Chicago, Illinois);  Suzanne D. CONZEN (Park Ridge, Illinois)
ABSTRACT Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound.
FILED Tuesday, January 18, 2022
APPL NO 17/577882
CURRENT CPC
Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle
A61J 1/00 (20130101)

Preparations for Medical, Dental, or Toilet Purposes
A61K 31/58 (20130101)
A61K 31/282 (20130101)
A61K 31/337 (20130101)
A61K 31/357 (20130101)
A61K 31/567 (20130101)
A61K 31/575 (20130101) Original (OR) Class
A61K 31/4745 (20130101)
A61K 31/7068 (20130101)
A61K 33/243 (20190101)
A61K 39/3955 (20130101)
A61K 45/06 (20130101)

Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy
A61N 5/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133747 Pietras et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Richard J. Pietras (Sherman Oaks, California);  Michael E. Jung (Los Angeles, California)
ABSTRACT Described herein, inter alia, are compositions and methods for treating or preventing hyperproliferative disorders, including cancer.
FILED Thursday, June 06, 2019
APPL NO 15/734199
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/58 (20130101) Original (OR) Class
A61K 31/565 (20130101)
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133756 RADTKE
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) KATHERINE L. RADTKE (BALTIMORE, Maryland)
ABSTRACT The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses.
FILED Thursday, January 06, 2022
APPL NO 17/569804
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/506 (20130101)
A61K 31/675 (20130101)
A61K 31/683 (20130101) Original (OR) Class
A61K 45/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133760 Sarthy et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Fred Hutchinson Cancer Research Center (Seattle, Washington)
ASSIGNEE(S) Fred Hutchinson Cancer Research Center (Seattle, Washington)
INVENTOR(S) Jay Francis Sarthy (Seattle, Washington);  Antoine Molaro (Clermont-Ferrand, France);  Marie Bleakley (Seattle, Washington);  Guo-Liang Chew (Singapore, Singapore)
ABSTRACT The present disclosure describes methods of treating lymphoma that expresses a short histone H2A variant. In some embodiments, the method can comprise collecting a sample from a subject having or suspected of having lymphoma, detecting a short histone H2A variant (sH2A) expression level in the sample collected from the subject, and administering to the subject a therapeutically effective dose of an anthracycline agent, if the subject has sH2A variant expression level that is detectable. In other embodiments, the sH2A is the H2A.B variant. In other embodiments, the anthracycline agent can be aclarubicin.
FILED Monday, November 01, 2021
APPL NO 17/516600
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/136 (20130101)
A61K 31/704 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101)
C12Q 2600/112 (20130101)
C12Q 2600/156 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133761 WANG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) WASHINGTON STATE UNIVERSITY (Pullman, Washington)
ASSIGNEE(S)
INVENTOR(S) Zhenjia WANG (Spokane, Washington);  Canyang ZHANG (Pullman, Washington)
ABSTRACT Disclosed are methods and compounds to selectively target the apoptosis pathway in proinflammatory neutrophils using Topoisomerase nanoparticles (NPs). The design of the disclosed nanoparticles (NPs) allows controlled release of DOX inside neutrophils, thus avoiding systemic toxicity. One such beneficial method for treating a subject neutrophil-inflammatory infection or tissue injury response includes administering a topoisomerase-conjugated albumin protein nanoparticles (NPs) composition to the subject, wherein the composition includes an effective amount so as to induce apoptosis of neutrophils, wherein the neutrophil induced inflammatory response is lower following the administration of the composition.
FILED Wednesday, November 03, 2021
APPL NO 17/518031
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/704 (20130101) Original (OR) Class
A61K 47/643 (20170801)
A61K 47/6929 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 29/00 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133767 SLACK et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Frank SLACK (Waban, Massachusetts);  Wen Cai ZHANG (Brookline, Massachusetts)
ABSTRACT The invention provides methods and compositions for use in targeting micro RNAs (miRNAs), as well as methods and compositions for use in treating, reducing, inhibiting, or delaying resistance or tolerance to anti-cancer treatment, and methods and compositions for use in treating or preventing cancer.
FILED Wednesday, February 19, 2020
APPL NO 17/431474
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/506 (20130101)
A61K 31/5377 (20130101)
A61K 31/7088 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0693 (20130101)
C12N 15/113 (20130101)
C12N 2310/14 (20130101)
C12N 2310/20 (20170501)
C12N 2310/113 (20130101)
C12N 2310/3231 (20130101)
C12N 2320/31 (20130101)
C12N 2501/06 (20130101)
C12N 2503/02 (20130101)
C12N 2513/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133770 Karin et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Environmental Health Sciences (NIEHS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Michael Karin (La Jolla, California);  Elsa Sanchez-Lopez (La Jolla, California)
ABSTRACT Provided herein are methods of treating macrophage-mediated inflammatory diseases and disorders. Also, disclosed are methods for screening for agents useful in such methods.
FILED Tuesday, February 04, 2020
APPL NO 17/428544
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101) Original (OR) Class
A61K 45/06 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133792 SENTMAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire)
ASSIGNEE(S)
INVENTOR(S) Charles SENTMAN (Grantham, New Hampshire);  David GRABER (Hanover, New Hampshire);  W. James COOK (Hanover, New Hampshire)
ABSTRACT Chimeric antigen receptors (CARs) are disclosed, along with nucleic acids and vectors encoding, and recombinant cells comprising such CARs and therapeutic compositions containing any of the foregoing. The CARs may comprise mutations that alter CAR expression, cytotoxicity, or cytokine production. Also provided are methods for using recombinant cells comprising these CARs for immunotherapy, e.g., in treating cancer by the administration of a therapeutically effective amount of one or more of the CAR polypeptides, nucleic acids, vectors, and/or immune cells, e.g., human CAR T cells, described herein optionally in combination with other immune and cancer treatments.
FILED Friday, January 31, 2020
APPL NO 17/427117
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/7051 (20130101)
C07K 14/70521 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133797 Roybal et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Kole T. Roybal (San Francisco, California);  Raymond Liu (San Francisco, California);  Iowis Zhu (San Francisco, California)
ABSTRACT The present disclosure generally relates to, inter alia, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. In addition, the new receptors described herein incorporate an extracellular oligomerization domain to promote oligomer formation of the chimeric receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as cancers.
FILED Wednesday, November 17, 2021
APPL NO 17/529091
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/705 (20130101)
C07K 14/70517 (20130101)
C07K 14/70521 (20130101)
C07K 16/32 (20130101)
C07K 16/2803 (20130101)
C07K 16/2878 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133818 COLGAN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Sean P. COLGAN (Foxfield, Colorado);  Joseph Scott LEE (Denver, Colorado);  Daniel J. KAO (Denver, Colorado)
ABSTRACT Methods of treating, reducing the risk of, preventing, or alleviating a symptom of inflammation or inflammatory gastrointestinal disease by administration of a modified bacterium providing purines, in particular hypoxanthine, to the mucosa of the intestine, and compositions containing modified bacteria useful in such methods.
FILED Wednesday, February 26, 2020
APPL NO 17/433713
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/745 (20130101) Original (OR) Class
A61K 35/747 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133821 Occhino et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
APPLICANT(S) Mayo Foundation for Medical Education and Research (Rochester, Minnesota)
ASSIGNEE(S)
INVENTOR(S) John A. Occhino (Rochester, Minnesota);  Marina R. Walther-Antonio (Rochester, Minnesota);  Douglas Allan Leach (Chesapeake, Virginia)
ABSTRACT Methods and materials involved in assessing and treating a mammal having a rectovaginal fistula (RVF) are provided herein. For example, the methods and materials described herein can be used for determining if a mammal having a RVF is likely to experience a successful outcome after surgical repair of the RVF, or if the mammal is likely to experience recurrence. Methods and materials for modulating the rectal and/or vaginal microbiome of mammal having a RVF also are provided herein.
FILED Thursday, November 04, 2021
APPL NO 17/519186
CURRENT CPC
Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General
A23L 33/135 (20160801)

Preparations for Medical, Dental, or Toilet Purposes
A61K 35/748 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133824 Thorne et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
INVENTOR(S) Stephen Howard Thorne (Pittsburgh, Pennsylvania);  Daniel J. Byrd (Pittsburgh, Pennsylvania)
ABSTRACT This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.
FILED Thursday, January 13, 2022
APPL NO 17/574691
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 35/768 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/07 (20130101)
C07K 14/16 (20130101)
C07K 14/4702 (20130101)
C07K 16/2827 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/16 (20130101)
C12N 9/104 (20130101)
C12N 15/625 (20130101)
C12N 2710/24132 (20130101)
C12N 2710/24143 (20130101)

Enzymes
C12Y 301/03048 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133825 Thorne et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
INVENTOR(S) Stephen Howard Thorne (Pittsburgh, Pennsylvania);  Daniel J. Byrd (Pittsburgh, Pennsylvania)
ABSTRACT This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers.
FILED Thursday, January 13, 2022
APPL NO 17/574763
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0019 (20130101)
A61K 35/768 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/07 (20130101)
C07K 14/16 (20130101)
C07K 14/4702 (20130101)
C07K 16/2827 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/16 (20130101)
C12N 9/104 (20130101)
C12N 15/625 (20130101)
C12N 2710/24132 (20130101)
C12N 2710/24143 (20130101)

Enzymes
C12Y 301/03048 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133847 Alles et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Sascha Alles (Albuquerque, New Mexico);  Karin Westlund High (Albuquerque, New Mexico)
ABSTRACT A therapeutic composition includes a Cav3.3 inhibitor and a pharmaceutically acceptable carrier. In some embodiments the Cav3.3 inhibitor can include a polypeptide such as, for example, the amino acid sequence of SEQ ID NO:1, an antibody, or fragment thereof. In some embodiments, the Cav3.3 inhibitor can include an inhibitory polynucleotide such as, for example, an anti-sense oligonucleotide that either hybridizes to a portion of Cacnali or hybridizes to an RNA transcribed from a portion of Cacnali. The therapeutic composition can be administered to a subject to alleviate pain in the subject or to increase the subject's mechanical withdrawal threshold. The composition can be used to reduce Cav3.3 expression in a cell.
FILED Tuesday, November 02, 2021
APPL NO 17/517045
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/17 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 29/00 (20180101)

Peptides
C07K 16/28 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1138 (20130101)
C12N 2310/11 (20130101)
C12N 2320/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133848 Eggan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Kevin C. Eggan (Boston, Massachusetts);  Joseph Robert Klim (Boston, Massachusetts);  Francesco Limone (Cambridge, Massachusetts);  Irune Guerra San Juan (Cambridge, Massachusetts);  Luis Williams (Cambridge, Massachusetts)
ABSTRACT The disclosure relates to compositions and methods for treating a disease or condition associated with a TDP-pathology or a decline in TDP-43 functionality in neuronal cells in a subject, and for identifying candidate agents to restore expression of a normal full-length or protein coding STMN2 RNA.
FILED Tuesday, January 14, 2020
APPL NO 17/423104
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7088 (20130101)
A61K 38/1703 (20130101) Original (OR) Class
A61K 48/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6851 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5058 (20130101)
G01N 33/6896 (20130101)
G01N 2800/28 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133859 Yang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Otto O. Yang (Los Angeles, California);  Yunfeng Lu (Culver City, California);  Cheng Ji (Los Angeles, California);  Ming Yan (Los Angeles, California);  Yang Liu (Los Angeles, California)
ABSTRACT The invention disclosed herein includes nanocomplexes that are designed include enzymes that have complementary functional attributes and methods for using these nanocomplexes. Illustrative examples include nanocomplexes that comprise both an alcohol oxidase enzyme as well as a catalase enzyme. These nanocomplexes can be used in methods designed to lower blood alcohol levels in vivo, and/or to break down the toxic byproducts of alcohol metabolism. Consequently these nanocomplexes can be used to treat a variety of conditions resulting from the consumption of alcohol, including for example, acute alcohol intoxication.
FILED Friday, March 20, 2020
APPL NO 16/825806
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/44 (20130101)
A61K 38/443 (20130101) Original (OR) Class
A61K 47/64 (20170801)
A61K 47/549 (20170801)

Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 5/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 11/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133877 Martinez-Sobrido et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) University of Rochester (Rochester, New York);  UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (Lexington, Kentucky);  ZOETIS SERVICES LLC (Parsippany, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Luis Martinez-Sobrido (Rochester, New York);  Thomas Chambers (Lexington, Kentucky);  Kendall Wayne King (Kalamazoo, Michigan)
ABSTRACT The present invention provides compositions and methods related to equine live-attenuated influenza vaccines. In one aspect, the invention relates to a composition comprising a multivalent equine live-attenuated influenza vaccine comprising a first live-attenuated influenza virus expressing one or more antigens of a clade 1 H3N8 equine influenza virus; and a second live-attenuated influenza virus expressing one or more antigens of a clade 2 H3N8 equine influenza virus, wherein the second live-attenuated influenza virus expresses HA, NA, or a combination thereof of A/equine/Lancashire/1/2016 H3N8.
FILED Thursday, February 27, 2020
APPL NO 17/434489
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/145 (20130101) Original (OR) Class
A61K 2039/5254 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133887 REIMANN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts);  Emory University (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Keith A. REIMANN (Marblehead, Massachusetts);  Rijian WANG (Saugus, Massachusetts);  Christian P. LARSEN (Atlanta, Georgia)
ABSTRACT The present invention relates to antibodies specific for a particular epitope on CD40 and antibodies that bind CD40 and have particular functional characteristics. The present invention also relates to fragments of these antibodies, uses of the antibodies for reduction or treatment of transplant rejection and graft-versus-host disease, and methods for making the antibodies.
FILED Wednesday, January 12, 2022
APPL NO 17/573730
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/436 (20130101)
A61K 38/13 (20130101)
A61K 39/3955 (20130101) Original (OR) Class
A61K 39/39541 (20130101)
A61K 45/06 (20130101)
A61K 2039/505 (20130101)
A61K 2039/507 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 37/06 (20180101)

Peptides
C07K 16/18 (20130101)
C07K 16/2866 (20130101)
C07K 16/2875 (20130101)
C07K 16/2878 (20130101)
C07K 2317/24 (20130101)
C07K 2317/33 (20130101)
C07K 2317/76 (20130101)

Technologies for Adaptation to Climate Change
Y02A 50/30 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133893 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Yupeng Chen (Farmington, Connecticut);  Jinhyung Lee (Farmington, Connecticut)
ABSTRACT Disclosed herein is a delivery vehicle based on DNA-inspired Janus based nanotubes (JBNTs) for anti-viral treatment. The nanoparticles (NPs) are based the JBNTs conjugated with targeting moieties such as small molecules, aptamers, and peptides.
FILED Friday, October 29, 2021
APPL NO 17/514390
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/51 (20130101)
A61K 31/194 (20130101)
A61K 31/519 (20130101)
A61K 31/721 (20130101)
A61K 31/722 (20130101)
A61K 31/727 (20130101)
A61K 31/728 (20130101)
A61K 38/19 (20130101)
A61K 38/40 (20130101)
A61K 38/363 (20130101)
A61K 38/385 (20130101)
A61K 47/65 (20170801)
A61K 47/545 (20170801) Original (OR) Class
A61K 47/6929 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/12 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133896 Duan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska)
ASSIGNEE(S)
INVENTOR(S) Bin Duan (Omaha, Nebraska);  Mitchell Kuss (Omaha, Nebraska);  Tammy Kielian (LaVista, Nebraska);  Amy Aldrich (Omaha, Nebraska);  Wen Shi (Pappillion, Nebraska)
ABSTRACT Three-dimensional printed antibiotic scaffolds are provided as well as methods of use thereof and methods of making.
FILED Friday, March 06, 2020
APPL NO 17/431049
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/496 (20130101)
A61K 38/12 (20130101)
A61K 47/61 (20170801) Original (OR) Class
A61K 47/6903 (20170801)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/52 (20130101)
A61L 27/54 (20130101)
A61L 2300/406 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 70/10 (20200101)
B33Y 80/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133909 Boye et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida)
ASSIGNEE(S) University of Florida Research Foundation, Incorporated (Gainesville, Florida)
INVENTOR(S) Shannon E. Boye (Gainesville, Florida);  Sanford L. Boye (Gainesville, Florida)
ABSTRACT The disclosure provides rAAV particles comprising a new capsid variant, AAV44.9(E531D). The disclosure also provides rAAV particles comprising AAV44.9(E531D) for treatment of the eye, including treatment of retinal disorders. In particular embodiments, the disclosure provides rAAV particles comprising an AAV44.9(E531D) capsid that exhibits enhanced lateral spread after subretinal injection to a fovea of the subject, wherein detachment of the fovea is minimized. The disclosure further provides rAAV particles comprising an AAV44.9(E531D) capsid and a polynucleotide encoding a heterologous nucleic acid sequence. Methods of treatment comprising administering rAAV particles to a mammal in need thereof, and methods of transducing photoreceptor and RPE cells with rAAV particles, are also provided.
FILED Thursday, January 23, 2020
APPL NO 17/425292
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 48/0058 (20130101) Original (OR) Class
A61K 48/0075 (20130101)

Peptides
C07K 14/005 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)
C12N 2750/14122 (20130101)
C12N 2750/14143 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133910 Hu
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Eye Institute (NEI)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S)
INVENTOR(S) Yang Hu (Palo Alto, California)
ABSTRACT Compositions and methods for treating a mammalian subject for an optic nerve (ON) neuropathy and/or reducing or ameliorating degeneration of axons and/or soma of RGCs are provided. Aspects of the composition include a mammalian viral vector, comprising a murine g-synuclein promoter, or functional fragment thereof, that promotes expression of a transgene specifically in retinal ganglion cells (RGCs), said promoter in operable linkage with an expression cassette encoding the transgene, wherein the expressed transgene inhibits activity of an expression product of an endogenous pro-neurodegenerative gene involved in an ER stress and/or UPR pathway that leads to axon or soma degeneration in the RGCs. Aspects of the methods include intravitreally administering the composition to treat the subject for the ON neuropathy. A variety of ON neuropathies may be treated by practicing the methods, including retinal ganglion cell degeneration, glaucoma, optic neuritis, ON traumatic injury and other ON-related diseases.
FILED Friday, February 28, 2020
APPL NO 17/432794
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0048 (20130101)
A61K 31/7105 (20130101)
A61K 35/76 (20130101)
A61K 38/465 (20130101)
A61K 48/0058 (20130101) Original (OR) Class

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/02 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133916 Hooker et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) The General Hospital Corporation (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Jacob Hooker (Belmont, Massachusetts);  Changning Wang (Melrose, Massachusetts);  Martin Georg Strebl-Bantillo (Somerville, Massachusetts);  Johanna Kaarina Rokka (Boston, Massachusetts)
ABSTRACT Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.
FILED Tuesday, November 16, 2021
APPL NO 17/455170
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 51/04 (20130101) Original (OR) Class

General Methods of Organic Chemistry; Apparatus Therefor
C07B 2200/05 (20130101)

Acyclic or Carbocyclic Compounds
C07C 259/10 (20130101)
C07C 2602/42 (20170501)
C07C 2603/74 (20170501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220134051 Boes
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) University of Iowa Research Foundation (Iowa City, Iowa)
ASSIGNEE(S)
INVENTOR(S) Aaron Boes (Iowa City, Iowa)
ABSTRACT A multimodal sensory device for promoting sleep in a subject, including a first sensory delivery component, a second sensory delivery component, and a controller module. The sensory device wherein the first and second sensory delivery components are constructed and arranged for delivering a first and second sensory stimuli to the subject and the controller is constructed and arranged to deliver the first and second sensory stimuli at a synchronized frequency. A method for promoting sleep in a subject including delivering to the subject at least one sensory stimuli at a frequency of between about 1 and 60 hz.
FILED Wednesday, November 03, 2021
APPL NO 17/518301
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/291 (20210101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 21/02 (20130101) Original (OR) Class
A61M 2021/0044 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220134337 Aksimentiev
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S) Aleksei Aksimentiev (Urbana, Illinois)
ABSTRACT Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane, wherein the membrane has a first side and a second side, wherein the membrane has a first pore disposed therein, wherein the first pore extends through the membrane from the first side of the membrane to the second side of the membrane, wherein the membrane has a second pore disposed therein, and wherein the second pore extends through the membrane from the first side of the membrane to the second side of the membrane; a first channel disposed on the first side of the membrane, wherein the first channel is along a first longitudinal axis; a second channel disposed on the first side of the membrane, wherein the second channel is along a second longitudinal axis, and wherein the first channel and the second channel are disposed side by side adjacent to each other; a third channel disposed on the second side of the membrane, wherein the third channel is along a third longitudinal axis, wherein the third channel is in first fluid communication with the first channel via the first pore, and wherein the third channel is in second fluid communication with the second channel via the second pore; and one or more sensors disposed at one or more locations to facilitate sequencing of a molecule that extends from the first channel, through the first pore across at least a portion of the third channel, and through the second pore into the second channel. Additional embodiments are disclosed.
FILED Thursday, October 28, 2021
APPL NO 17/513516
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502715 (20130101) Original (OR) Class
B01L 2200/0652 (20130101)
B01L 2300/0663 (20130101)
B01L 2300/0896 (20130101)
B01L 2400/0415 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6869 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135518 Lim et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) AmberGen, Inc. (Watertown, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Mark J. Lim (Reading, Massachusetts);  Gargey Yagnik (Hopkinton, Massachusetts);  Kenneth J. Rothschild (Newton, Massachusetts)
ABSTRACT The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme).
FILED Wednesday, August 11, 2021
APPL NO 17/399461
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 271/20 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6851 (20130101)
G01N 2458/15 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135529 Ray et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Johns Hopkins University (Baltimore, Maryland);  Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Sangeeta Ray (Ellicott City, Maryland);  Martin G. Pomper (Baltimore, Maryland);  Thomas J. Meade (Wilmette, Illinois);  Ronnie C. Mease (Fairfax, Virginia);  Ying Chen (Timmonium, Maryland);  Xing Yang (Baltimore, Maryland);  Matthew Rotz (Carlsbad, California)
ABSTRACT Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific T1-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.
FILED Thursday, January 13, 2022
APPL NO 17/575235
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 49/0002 (20130101)
A61K 49/12 (20130101)
A61K 49/106 (20130101)
A61K 49/108 (20130101)
A61K 51/06 (20130101)
A61K 51/0402 (20130101)
A61K 51/0482 (20130101)
A61K 51/0497 (20130101)

Heterocyclic Compounds
C07D 257/02 (20130101) Original (OR) Class
C07D 403/14 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135556 Remiszewski et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Evrys Bio, LLC (Doylestown, Pennsylvania)
ASSIGNEE(S) Evrys Bio, LLC (Doylestown, Pennsylvania)
INVENTOR(S) Stacy Remiszewski (Doylestown, Pennsylvania);  Emre Koyuncu (Doylestown, Pennsylvania);  Qun Sun (Princeton, New Jersey);  Lillian Chiang (Princeton, New Jersey)
ABSTRACT Novel compounds useful for treating and/or preventing HCMV infections are provided.
FILED Thursday, January 13, 2022
APPL NO 17/574884
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/427 (20130101)
A61K 31/436 (20130101)
A61K 31/498 (20130101)
A61K 31/506 (20130101)
A61K 31/4709 (20130101)
A61K 31/4725 (20130101)
A61K 31/5377 (20130101)
A61K 45/06 (20130101)

Heterocyclic Compounds
C07D 417/04 (20130101)
C07D 417/06 (20130101)
C07D 417/10 (20130101)
C07D 417/14 (20130101) Original (OR) Class
C07D 491/052 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135625 Baric et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Ralph Baric (Haw River, North Carolina);  Harold Kenneth Dinnon, III (Chapel Hill, North Carolina);  Sarah Rebecca Leist (Carrboro, North Carolina);  Yixuan Hou (Chapel Hill, North Carolina)
ABSTRACT This invention relates to SARS-CoV-2 viruses adapted with nanoluciferase reporter molecules and mouse-adapted SARS-CoV-2 viruses, compositions including the same and methods of use thereof.
FILED Monday, December 20, 2021
APPL NO 17/556413
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 39/215 (20130101)
A61K 2039/53 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/14 (20180101)

Peptides
C07K 14/005 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/56983 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135633 COHEN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Tufts Medical Center (Boston, Massachusetts);  Trustees of Tufts College (Medford, Massachusetts);  On Target Therapeutics LLC (Wellesley, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Charles COHEN (Weston, Massachusetts);  Krishna KUMAR (Cambridge, Massachusetts);  Jamie Raudensky DOYLE (Newton, Massachusetts);  Alan S. KOPIN (Wellesley, Massachusetts)
ABSTRACT The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.
FILED Friday, November 12, 2021
APPL NO 17/525169
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)
A61K 47/543 (20170801)

Peptides
C07K 7/06 (20130101)
C07K 7/08 (20130101)
C07K 14/4703 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/92 (20130101)
G01N 33/5023 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135634 QU et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
ASSIGNEE(S) UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania)
INVENTOR(S) Zhaoxia QU (Pittsburgh, Pennsylvania);  Gutian XIAO (Pittsburg, Pennsylvania)
ABSTRACT The present disclosure provides methods and compositions for treating cancer (e.g., lung cancer) in a subject by increasing the expression of PDZ-LIM domain containing protein 2 (PDLIM2) in the subject, or a functional fragment thereof. The present disclosure further provides methods of using PDLIM2 as a marker for determining and monitoring a subject's responsiveness to an anti-cancer treatment, providing a prognosis about a cancer in a subject, and selecting an effective anti-cancer treatment for a subject. The present disclosure also provides in vitro methods of screening anti-cancer agents by assessing whether the expression of PDLIM2 is restored by an anti-cancer agent in a cancer cell.
FILED Friday, January 14, 2022
APPL NO 17/576112
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 45/06 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 14/4703 (20130101) Original (OR) Class
C07K 16/2818 (20130101)
C07K 16/2827 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135643 Hagood et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina);  The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) James Hagood (Chapel Hill, North Carolina);  Simon Wong (La Jolla, California)
ABSTRACT The invention relates to a soluble Thy-1 polypeptide or a functional fragment thereof and pharmaceutical compositions including the soluble Thy-1 polypeptide or a functional fragment thereof. The invention also relates to the use of the soluble Thy-1 polypeptide or a functional fragment thereof for delivery to subjects with tissue fibrosis for treating, inhibiting, and/or reversing tissue fibrosis in the subject.
FILED Friday, October 29, 2021
APPL NO 17/514954
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/00 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 11/00 (20180101)

Peptides
C07K 14/70503 (20130101) Original (OR) Class

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/63 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135655 Marasco et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Wayne A. Marasco (Wellesley, Massachusetts);  Yuval Avnir (Boston, Massachusetts)
ABSTRACT The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection.
FILED Monday, July 26, 2021
APPL NO 17/385465
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6841 (20170801)

Peptides
C07K 16/1018 (20130101) Original (OR) Class
C07K 2317/21 (20130101)
C07K 2317/54 (20130101)
C07K 2317/55 (20130101)
C07K 2317/56 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)
C07K 2317/565 (20130101)
C07K 2317/567 (20130101)
C07K 2317/622 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6876 (20130101)
C12Q 2600/106 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5052 (20130101)
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135661 LUK et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Kelvin C. LUK (Philadelphia, Pennsylvania);  Virginia M.Y. LEE (Philadelphia, Pennsylvania);  John Q. TROJANOWSKI (Philadelphia, Pennsylvania);  Kurt R. BRUNDEN (Media, Pennsylvania);  Dustin COVELL (Philadelphia, Pennsylvania)
ABSTRACT The present disclosure provides monoclonal antibodies that bind α-Synuclein. In certain aspects, the antibodies preferentially bind to α-Synuclein fibrils over α-Synuclein monomer. In other aspects, the invention comprises a method of treating α-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting α-Synuclein fibrils using any of the antibodies of the invention.
FILED Monday, January 10, 2022
APPL NO 17/572309
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/0029 (20130101)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 25/28 (20180101)

Peptides
C07K 16/18 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/577 (20130101)
G01N 33/6896 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135678 Chaudhary
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
APPLICANT(S) University of Southern California (Los Angeles, California)
ASSIGNEE(S)
INVENTOR(S) Preet M. Chaudhary (Toluca Lake, California)
ABSTRACT Described herein are novel compositions and methods to improve the safety and efficacy of adoptive cellular therapies of cancer, infection, allergic, degenerative and immune disorders. The disclosure provides a) novel methods and compositions to reduce the accidental insertion of chimeric receptors into cancer cells; b) novel methods to measure the titer of viral vectors; c) novel compositions to generate antigen masking receptors and methods to use such receptors to protect normal cells from immunotherapeutic agents; d) novel compositions and methods to extend the life-span of allogeneic cells, including allogeneic CAR-T cells; e) novel compositions and methods to ameliorate the side-effects of cellular therapies and f) novel compositions of Synthetic Immune Receptors and Ab-TCRs with mutant TCRα constant chains.
FILED Saturday, January 18, 2020
APPL NO 17/423894
CURRENT CPC
Peptides
C07K 16/2809 (20130101) Original (OR) Class
C07K 16/2863 (20130101)
C07K 16/2875 (20130101)
C07K 16/2878 (20130101)
C07K 16/2887 (20130101)
C07K 16/2893 (20130101)
C07K 16/3007 (20130101)
C07K 2317/31 (20130101)
C07K 2317/622 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135692 LEE et al.
FUNDED BY
Department of Health and Human Services (HHS)
APPLICANT(S) The University of Bristol (Bristol, United Kingdom);  The Government of the U.S.A., as represented by the Secretary of the Department of Health and Human (Bethesda, Maryland)
ASSIGNEE(S)
INVENTOR(S) Richard LEE (Bristol, United Kingdom);  Andrew DICK (Bristol, United Kingdom);  Lauren SCHEWITZ BOWERS (Bristol, United Kingdom);  Robert NUSSENBLATT (Bethesda, Maryland);  Igal GERY (Bethesda, Maryland);  Lai WEI (Bethesda, Maryland)
ABSTRACT The present invention relates to a conjugate that specifically targets a calcineurin inhibitor to T cells, such as Th17 cells, for use in a method for the treatment of an inflammatory disease. The invention also relates to a method for treating an inflammatory disease by administering a conjugate that specifically targets a calcineurin inhibitor to T cells, such as Th17 cells. In addition, the invention relates to a method for identifying a subject likely to be resistant to steroid treatment, as well as a subject likely to benefit from treatment with a calcineurin inhibitor.
FILED Wednesday, November 24, 2021
APPL NO 17/534909
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6803 (20170801)
A61K 47/6811 (20170801)
A61K 47/6849 (20170801)

Peptides
C07K 16/2866 (20130101) Original (OR) Class
C07K 2317/55 (20130101)
C07K 2317/77 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6869 (20130101)
G01N 33/6872 (20130101)
G01N 2333/7158 (20130101)
G01N 2800/52 (20130101)
G01N 2800/065 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135698 Ho et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) ImaginAb, Inc. (Inglewood, California)
ASSIGNEE(S)
INVENTOR(S) David T. Ho (Long Beach, California);  Tove Olafsen (Reseda, California);  Arye Lipman (El Segundo, California)
ABSTRACT In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA, an artificial hinge sequence, and a human IgG CH3 sequence. In another embodiment, a CysDB monomer that binds PSMA is provided. The CysDB monomer may be encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA and a cysteine tail. In other embodiments, methods for diagnosing or treating a cancer associated with PSMA expression in a subject are provided.
FILED Tuesday, November 16, 2021
APPL NO 17/455097
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 51/1072 (20130101)
A61K 2039/505 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Peptides
C07K 16/3069 (20130101) Original (OR) Class
C07K 2317/24 (20130101)
C07K 2317/56 (20130101)
C07K 2317/64 (20130101)
C07K 2317/77 (20130101)
C07K 2317/90 (20130101)
C07K 2317/526 (20130101)
C07K 2317/622 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135704 Tsimikas et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Sotirios Tsimikas (San Diego, California);  Joseph Witztum (San Diego, California);  Xuchu Que (San Diego, California)
ABSTRACT The disclosure provides for single chain variable fragments to MAA-oxidized specific epitopes (OSEs). The disclosure also provides single chain variable fragments that bind to MDA-OSEs or MAA-OSEs on oxidized phospholipids and methods of use thereof, including the production of transgenic animal models and the use of the fragments as therapeutic agents.
FILED Wednesday, October 13, 2021
APPL NO 17/500794
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/16 (20180101)
A61P 9/10 (20180101)

Peptides
C07K 16/44 (20130101) Original (OR) Class
C07K 2317/21 (20130101)
C07K 2317/24 (20130101)
C07K 2317/565 (20130101)
C07K 2317/622 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5308 (20130101)
G01N 2800/085 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135925 Reiserer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
National Institute of Child Health and Human Development (NICHD)
National Institute of Neurological Disorders and Stroke (NINDS)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Ronald S. Reiserer (Nashville, Tennessee);  Gregory B. Gerken (Nashville, Tennessee);  David K. Schaffer (Nashville, Tennessee);  John P. Wikswo (Brentwood, Tennessee)
ABSTRACT A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes.
FILED Wednesday, January 19, 2022
APPL NO 17/578966
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 23/08 (20130101)
C12M 23/10 (20130101)
C12M 23/12 (20130101)
C12M 23/16 (20130101)
C12M 23/50 (20130101)
C12M 23/58 (20130101)
C12M 27/02 (20130101)
C12M 27/12 (20130101)
C12M 29/10 (20130101) Original (OR) Class
C12M 35/02 (20130101)
C12M 35/04 (20130101)
C12M 41/48 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135951 Czirok et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) The University of Kansas (Lawrence, Kansas)
ASSIGNEE(S)
INVENTOR(S) Andras Czirok (Roeland Park, Kansas);  Pamela Tran (Overland Park, Kansas)
ABSTRACT A renal tube assay device can include: a container having an inlet port and an outlet port; a matrix material in the container; and a lumen in the matrix material extending from the inlet port to the outlet port. The lumen can include a luminal surface with at least one low density region that has a lower density compared to another adjacent region of the matrix material that is located at least partially around the at least one low density region. The low density region can have a form of a bubble, bulge, capsule, or the like. The low density region can bulge into the lumen. A port can be adapted for receiving a pipette tip. The matrix material can include a hydrogel. The container can be located in a cell culture dish.
FILED Wednesday, November 03, 2021
APPL NO 17/518395
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 23/06 (20130101)
C12M 23/16 (20130101)
C12M 41/36 (20130101)
C12M 41/46 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0686 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5044 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135961 Agar et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
APPLICANT(S) Brandeis University (Waltham, Massachusetts)
ASSIGNEE(S) Brandeis University (Waltham, Massachusetts)
INVENTOR(S) Jeffrey N. Agar (Newton, Massachusetts);  Joseph Salisbury (Cranston, Rhode Island)
ABSTRACT Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.
FILED Thursday, January 13, 2022
APPL NO 17/574742
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/095 (20130101)
A61K 31/385 (20130101)

Peptides
C07K 19/00 (20130101)
C07K 2319/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/0089 (20130101)
C12N 9/96 (20130101) Original (OR) Class

Enzymes
C12Y 115/01001 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135967 Buckley et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
ASSIGNEE(S) DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts)
INVENTOR(S) Dennis Buckley (Jamaica Plain, Massachusetts);  Georg Winter (Vienna, Austria);  Andrew J. Phillips (Arlington, Massachusetts);  Timothy Heffernan (Sugar Land, Texas);  James Bradner (Weston, Massachusetts);  Justin Roberts (Cambridge, Massachusetts);  Behnam Nabet (Boston, Massachusetts)
ABSTRACT The present invention provides a means to modulate gene expression in vivo in a manner that avoids problems associated with CRISPR endogenous protein knock-out or knock-in strategies and strategies that provide for correction, or alteration, of single nucleotides. The invention includes inserting into the genome a nucleotide encoding a heterobifunctional compound targeting protein (dTAG) in-frame with the nucleotide sequence of a gene encoding an endogenously expressed protein of interest which, upon expression, produces an endogenous protein-dTAG hybrid protein. This allows for targeted protein degradation of the dTAG and the fused endogenous protein using a heterobifunctional compound.
FILED Thursday, January 20, 2022
APPL NO 17/580190
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/58 (20130101)
A61K 31/506 (20130101)
A61K 31/519 (20130101)
A61K 31/551 (20130101)
A61K 31/575 (20130101)
A61K 31/4525 (20130101)
A61K 31/4545 (20130101)
A61K 31/4985 (20130101)
A61K 31/5513 (20130101)
A61K 35/17 (20130101)
A61K 2035/122 (20130101)

Peptides
C07K 14/47 (20130101)
C07K 14/7051 (20130101)
C07K 14/70517 (20130101)
C07K 14/70521 (20130101)
C07K 16/00 (20130101)
C07K 16/2863 (20130101)
C07K 2317/622 (20130101)
C07K 2319/03 (20130101)
C07K 2319/20 (20130101)
C07K 2319/95 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/11 (20130101) Original (OR) Class
C12N 15/907 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135971 Tran et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) David Tran (Gainesville, Florida);  Son Bang Le (Gainesville, Florida)
ABSTRACT Provided methods of inhibiting a glioblastoma stem-like cell (GSC), methods of treating a subject with glioblastoma, and methods of reprogramming an astrocyte to a glioblastoma stem-like cell (GSC).
FILED Thursday, February 06, 2020
APPL NO 17/428722
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/7088 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/86 (20130101)
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/14 (20130101)
C12N 2310/122 (20130101)
C12N 2310/531 (20130101)
C12N 2320/32 (20130101)
C12N 2740/15043 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135973 GREENBERG et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Board of Regents, The University of Texas System (Austin, Texas);  Oregon State University (Corvallis, Oregon)
ASSIGNEE(S) Board of Regents, The University of Texas System (Austin, Texas);  Oregon State University (Corvallis, Oregon)
INVENTOR(S) David GREENBERG (Coppell, Texas);  Bruce L. GELLER (Corvallis, Oregon)
ABSTRACT Provided are antisense oligomers targeted against bacterial mRNAs and other macromolecules associated with a biochemical pathway and/or cellular process, and related compositions and methods of using the oligomers and compositions to treat an infected mammalian subject, for example, as primary antimicrobials or as adjunctive therapies with classic antimicrobials.
FILED Tuesday, October 12, 2021
APPL NO 17/498880
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/712 (20130101)
A61K 31/7115 (20130101)
A61K 47/42 (20130101)
A61K 47/66 (20170801)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2310/3233 (20130101)
C12N 2310/3513 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135975 SINGH et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute on Aging (NIA)
APPLICANT(S) UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER (Fort Worth, Texas)
ASSIGNEE(S)
INVENTOR(S) MEHARVAN SINGH (BENBROOK, Texas);  CHANG SU (LUCAS, Texas);  TRINH NGUYEN (HUMBLE, Texas)
ABSTRACT The subject invention provides methods of treating neurological disease or disorder, such as brain injuries, such as stroke, traumatic brain injury (TBI), or other ischemic events that cause brain injury by inhibiting or down-regulating Let-7i activity or function. The disclosed methods may have the potential to extend the “window of opportunity” for treatment of such injuries and enhance the effectiveness of existing therapeutics.
FILED Friday, January 21, 2022
APPL NO 17/580689
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/713 (20130101)
A61K 38/185 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/113 (20130101) Original (OR) Class
C12N 2310/11 (20130101)
C12N 2310/141 (20130101)
C12N 2320/31 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135982 CHEN et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Memorial Sloan Kettering Cancer Center (New York, New York)
ASSIGNEE(S)
INVENTOR(S) Chichao CHEN (New York, New York);  Scott LOWE (New York, New York)
ABSTRACT The present disclosure relates generally to compositions and methods for treating or ameliorating acute myeloid leukemia in a subject in need thereof. In particular, the present disclosure provides a method comprising administering to a subject a therapeutically effective amount of at least one agent that suppresses Trim28 activity.
FILED Thursday, February 06, 2020
APPL NO 17/428322
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/02 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/104 (20130101)
C12N 15/1137 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
C12N 2320/12 (20130101)
C12N 2320/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135985 Zhang et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Mental Health (NIMH)
APPLICANT(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Rockefeller University (New York, New York)
ASSIGNEE(S) The Broad Institute, Inc. (Cambridge, Massachusetts);  Massachusetts Institute of Technology (Cambridge, Massachusetts);  The Rockefeller University (New York, New York)
INVENTOR(S) Feng Zhang (Cambridge, Massachusetts);  David Benjamin Turitz Cox (Cambridge, Massachusetts);  Luciano Marraffini (New York, New York);  David Olivier Bikard (Paris, France);  Wenyan Jiang (Whitestone, New York);  Neville Espi Sanjana (Cambridge, Massachusetts)
ABSTRACT The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.
FILED Monday, October 18, 2021
APPL NO 17/503928
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/63 (20130101)
C12N 15/70 (20130101)
C12N 15/74 (20130101)
C12N 15/85 (20130101)
C12N 15/102 (20130101)
C12N 15/113 (20130101)
C12N 15/746 (20130101) Original (OR) Class
C12N 15/907 (20130101)
C12N 15/1082 (20130101)
C12N 15/8509 (20130101)
C12N 2310/20 (20170501)
C12N 2310/531 (20130101)
C12N 2310/3519 (20130101)
C12N 2800/101 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136002 Shultz
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) The Jackson Laboratory (Bar Harbor, Maine)
ASSIGNEE(S) The Jackson Laboratory (Bar Harbor, Maine)
INVENTOR(S) Leonard D. Shultz (Bar Harbor, Maine)
ABSTRACT Provided herein, in some aspects, is a NOD.Cg-Prkdcscid Il2rgtm1wjl/SzJ (NOD scid gamma or NSG™) mouse comprising a nucleic acid encoding human FLT3L and an inactivated mouse Flt3 allele, methods of producing the mouse, and methods of using the mouse.
FILED Thursday, February 13, 2020
APPL NO 17/430364
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 67/0275 (20130101)
A01K 2217/05 (20130101)
A01K 2227/105 (20130101)
A01K 2267/03 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0636 (20130101)
C12N 15/8509 (20130101) Original (OR) Class
C12N 2517/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136004 May et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Chan Zuckerberg Biohub, Inc. (San Francisco, California)
ASSIGNEE(S)
INVENTOR(S) Andrew P May (San Francisco, California);  Eleonore Tham (San Francisco, California);  Lucy Maynard (San Francisco, California);  Marco Mignardi (San Francisco, California);  Nicole K. Paulk (San Francisco, California);  Ryan T. Leenay (San Francisco, California);  Gagandeep Renuka Kumar (San Francisco, California)
ABSTRACT An in vivo method of modifying a genome of a target cell in a mammalian subject is described. The method includes administering an effective amount of a transducer cell to the subject, where the transducer cell includes a regulated viral vector delivery system (RVVDS) for producing and releasing viral transduction particles (VTPs) when the transducer cell is exposed to inducing conditions, and each VTP comprises a nucleic acid encoding a genome modification system (GMS) comprising a genome modification protein and one or more elements that regulate expression or activity of the genome modification protein in a mammalian cell.
FILED Monday, January 13, 2020
APPL NO 17/422173
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/65 (20130101)
A61K 35/15 (20130101)
A61K 48/005 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/22 (20130101)
C12N 15/11 (20130101)
C12N 15/86 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
C12N 2750/14143 (20130101)
C12N 2750/14171 (20130101)
C12N 2800/80 (20130101)
C12N 2830/002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136010 Samulski
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
NIH Office of the Director (NIHOD)
APPLICANT(S) The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Richard Jude Samulski (Hillsborough, North Carolina)
ABSTRACT Disclosed herein are methods and compositions comprising an adeno-associated virus 2.5 (AAV2.5) capsid protein, comprising one or more amino acids substitutions, (e.g., which does not contain a substitution at the position corresponding to amino acid 267 of AAV2.5, or does not contain a serine at the position corresponding to amino acid 267 of AAV2.5) wherein the substitutions introduce a new glycan binding site into the AAV capsid protein.
FILED Friday, January 21, 2022
APPL NO 17/581639
CURRENT CPC
Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 1/16 (20180101)
A61P 31/18 (20180101)
A61P 31/20 (20180101)

Peptides
C07K 14/005 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 7/00 (20130101)
C12N 15/86 (20130101) Original (OR) Class
C12N 2750/14122 (20130101)
C12N 2750/14142 (20130101)
C12N 2750/14143 (20130101)
C12N 2750/14171 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136019 Baker et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) University of South Florida (Tampa, Florida);  INSTITUTO POLITÉCNICO NACIONAL (MEXICO CITY, Mexico);  KING ABDULAZIZ UNIVERSITY (JEDDAH, Saudi Arabia)
ASSIGNEE(S)
INVENTOR(S) Bill J. Baker (Temple Terrace, Florida);  Dennis E. Kyle (Athens, Georgia);  Mario Alberto Rodriguez-Pérez (Reynosa, Mexico);  Anne-Claire D. Limon (Tampa, Florida);  Ala Azhari (Tampa, Florida)
ABSTRACT Described herein are methods of epigenetic modification of fungi and uses thereof. Also described herein are compounds that can have antileishmanial activity and formulations thereof. Also described herein are methods of treating leishmanial infection in a subject that include the step of administering a compound or formulation thereof described herein to the subject.
FILED Wednesday, August 18, 2021
APPL NO 17/406025
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/366 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 33/02 (20180101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/14 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 17/181 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136051 Fan et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) St. Jude Children's Research Hospital (Memphis, Tennessee)
ASSIGNEE(S) St. Jude Children's Research Hospital (Memphis, Tennessee)
INVENTOR(S) Yiping Fan (Memphis, Tennessee);  Jeremy Crawford (Memphis, Tennessee);  Benjamin Youngblood (Memphis, Tennessee)
ABSTRACT Provided herein are methods and compositions for determining T-cell differentiation by comparing the methylation status of T cells relative to a T cell methylation index and using this determination to identify or isolate populations of T cells having desired T cell multipotency. Further, the present methods and compositions can be used to monitor or treat symptoms of chronic infections, autoimmune diseases, and cancer.
FILED Monday, February 24, 2020
APPL NO 17/432721
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6881 (20130101) Original (OR) Class
C12Q 2600/154 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 40/20 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136059 Czyzyk-Krzeska et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Cincinnati (Cincinnati, Ohio)
ASSIGNEE(S) University of Cincinnati (Cincinnati, Ohio)
INVENTOR(S) Maria Franciszka Czyzyk-Krzeska (Cincinnati, Ohio);  Julio Alberto Landero Figueroa (Cincinnati, Ohio);  Jarek Meller (Cincinnati, Ohio);  David Plas (Cincinnati, Ohio);  Shuchi Gulati (Cincinnati, Ohio);  Bhargav Vemuri (Mason, Ohio);  John Thomas Cunningham, IV (Maineville, Ohio)
ABSTRACT A method of diagnosing the likelihood of recurrence of clear cell renal cell carcinoma is provided. The method involves a) detecting the gene expression signatures of mitochondrial electron transport chain subunits, mitochondrial ribosomal proteins, major histocompatibility complex class II (MHC-II) proteins or combinations thereof in a kidney tumor tissue sample; and b) determining that the subject has an elevated risk of recurrence of clear cell renal cell carcinoma if the gene expression signatures include certain sequences. In another embodiment, the method uses copper levels to diagnose the likelihood of recurrence of clear cell renal cell carcinoma.
FILED Friday, May 21, 2021
APPL NO 17/327100
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/118 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57438 (20130101)
G01N 2333/90216 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136068 SMITH et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Regents of the University of Colorado, A Body Corporate (Denver, Colorado)
ASSIGNEE(S)
INVENTOR(S) Clayton SMITH (Aurora, Colorado);  Craig T. JORDAN (Aurora, Colorado);  Daniel POLLYEA (Aurora, Colorado);  Shanshan PEI (Aurora, Colorado)
ABSTRACT The present disclosure relates to methods of identifying AML patients who will be resistant to venetoclax therapy and methods of treating venetoclax-resistant patients with myeloid leukemia cell differentiation protein (MCL-1) inhibitors.
FILED Friday, March 06, 2020
APPL NO 17/435728
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/496 (20130101)
A61K 31/706 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/02 (20180101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/106 (20130101)
C12Q 2600/158 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136949 Kimmerling et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Robert J. Kimmerling (Cambridge, Massachusetts);  Nicholas L. Calistri (New Fairfield, Connecticut);  Scott R. Manalis (Portland, Oregon);  Selim Olcum (Cambridge, Massachusetts);  Mark M. Stevens (Seattle, Washington)
ABSTRACT Systems and methods for flowing particles, such as biological entities, in a fluidic channel(s) are generally provided. In some cases, the systems described herein are designed such that a single particle may be isolated from a plurality of particles and flowed into a fluidic channel (e.g., a microfluidic channel) and/or collected e.g., on fluidically isolated surfaces. For example, the single particle may be present in a plurality of particles of relatively high density and the single particle is flowed into a fluidic channel, such that it is separated from the plurality of particles. The particles may be spaced within a fluidic channel so that individual particles may be measured/observed over time. In certain embodiments, the particle may be a biological entity. Such article and methods may be useful, for example, for isolating single cells into individual wells of multi-well cell culture dishes (e.g., for single-cell analysis).
FILED Thursday, October 07, 2021
APPL NO 17/496096
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502746 (20130101)
B01L 3/502753 (20130101)
B01L 3/502761 (20130101)
B01L 2300/0663 (20130101)
B01L 2300/0864 (20130101)
B01L 2400/0415 (20130101)
B01L 2400/0487 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/0205 (20130101)
G01N 15/0255 (20130101) Original (OR) Class
G01N 15/0618 (20130101)
G01N 15/1056 (20130101)
G01N 15/1484 (20130101)
G01N 2015/149 (20130101)
G01N 2015/0288 (20130101)
G01N 2015/1006 (20130101)
G01N 2015/1081 (20130101)
G01N 2015/1087 (20130101)
G01N 2015/1493 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136972 LEE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Ki-Bum LEE (Monmouth Junction, New Jersey);  Letao YANG (Edison, New Jersey)
ABSTRACT A surface-enhanced Raman scattering (SERS) sensing system or platform and methods of using the same, where the platform comprises a graphene coated-homogeneous plasmonic metal hybrid array, which synergizes both electromagnetic mechanism (EM)- and chemical mechanism (CM)-based signal enhancement for achieving sensitive and reproducible detection of Raman signals. The system and methods of using such system or platform may be applied to the analyses of various bio/chemical molecules, such as but not limited to those found in cells, in a highly sensitive and selective manner.
FILED Wednesday, October 27, 2021
APPL NO 17/512211
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6876 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/658 (20130101) Original (OR) Class
G01N 33/54306 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136973 Rodriguez et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Rebeca S. Rodriguez (St. Paul, Minnesota);  Victoria M. Szlag (St. Paul, Minnesota);  Theresa M. Reineke (Vadnais Heights, Minnesota);  Christy L. Haynes (Minneapolis, Minnesota)
ABSTRACT Methods and systems related to a linear polymer affinity agent sensor for SERS are disclosed. Use of the sensor may include mixing a linear polymer affinity agent in a sample solution, subjecting a metal substrate to the sample solution to attach the linear polymer affinity agent to the metal substrate, generating, via Raman Spectroscopy, spectral data representing the at least one linear polymer affinity agent attached to the metal substrate, and determining whether two or more analytes are present in the solution at respective minimum threshold concentrations based on the spectral data.
FILED Friday, October 29, 2021
APPL NO 17/514016
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/658 (20130101) Original (OR) Class
G01N 33/553 (20130101)
G01N 33/54373 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136999 Garimella et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Pacific Northwest National Laboratory (PNNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Memorial Institute (BMI) at Richland, WA
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Venkata BS Garimella (Richland, Washington);  Ahmed M. Hamid (Richland, Washington);  Yehia M. Ibrahim (West Richland, Washington);  Richard D. Smith (Richland, None)
ABSTRACT Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation.
FILED Tuesday, December 21, 2021
APPL NO 17/557690
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/624 (20130101) Original (OR) Class

Electric Discharge Tubes or Discharge Lamps
H01J 49/26 (20130101)
H01J 49/0027 (20130101)
H01J 49/062 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137026 Bass et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Joseph T. Bass (Winnetka, Illinois);  Clara Bien Peek (Chicago, Illinois);  Akihiko Taguchi (Chicago, Illinois);  Mark Perelis (Evanston, Illinois);  Biliana Marcheva (Evanston, Illinois)
ABSTRACT The present invention relates to cells with altered cell cycle control. In particular, the present invention provides cells with altered cell cycle control and uses of such cells to identify metabolically active agents.
FILED Thursday, January 13, 2022
APPL NO 17/574695
CURRENT CPC
Peptides
C07K 14/4702 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0658 (20130101)
C12N 5/0676 (20130101)
C12N 2510/00 (20130101)
C12N 2510/04 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6897 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/507 (20130101) Original (OR) Class
G01N 33/5005 (20130101)
G01N 33/5008 (20130101)
G01N 33/5061 (20130101)
G01N 2333/62 (20130101)
G01N 2800/042 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137053 Chilton et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)
APPLICANT(S) Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona)
ASSIGNEE(S)
INVENTOR(S) Floyd Chilton (Tucson, Arizona);  Ashley Jones Snider (Tucson, Arizona);  Justin Michael Snider (Tucson, Arizona)
ABSTRACT Provided herein are biomarkers for cancer screening and monitoring. In particular, provided herein are lipid biomarkers for cancer diagnosis, prognosis, risk, and response to treatment.
FILED Wednesday, January 29, 2020
APPL NO 17/310274
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5743 (20130101)
G01N 33/57423 (20130101)
G01N 33/57434 (20130101) Original (OR) Class
G01N 33/57442 (20130101)
G01N 33/57446 (20130101)
G01N 33/57449 (20130101)
G01N 2405/08 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137063 Regnier et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Novilytic, LLC (West Lafayette, Indiana)
ASSIGNEE(S)
INVENTOR(S) Fred Regnier (West Lafayette, Indiana);  Jinhee Kim (West Lafayette, Indiana);  Meena Narsimhan (West Lafayette, Indiana);  Paul Dreier (West Lafayette, Indiana)
ABSTRACT A system and method is provided for validating the manufacturing process for the production of complex biological compositions, and particularly for providing process validation information for evaluation by a federal regulatory agency. The system and method continuously and chronologically assess the concentration of proteoforms within the biological composition as it is being produced in a fermentor. Samples from the fermentor are analyzed in a pre-selected array of analysis columns, with data generated by the columns being accumulated and evaluated, and particularly compared with data from previous stages in the production process. A continuous process validation system includes top-down and bottom-up analysis sectors, each including a plurality of different analysis columns that can be selected by the controller for a particular biological composition and a particular production process.
FILED Thursday, September 16, 2021
APPL NO 17/476810
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/6428 (20130101)
G01N 30/14 (20130101)
G01N 30/72 (20130101)
G01N 33/6845 (20130101)
G01N 33/6848 (20130101) Original (OR) Class
G01N 2021/6432 (20130101)
G01N 2030/027 (20130101)
G01N 2560/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137064 Lim et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) AmberGen, Inc. (Watertown, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Mark J. Lim (Reading, Massachusetts);  Gargey Yagnik (Hopkinton, Massachusetts);  Kenneth J. Rothschild (Newton, Massachusetts)
ABSTRACT The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme).
FILED Wednesday, August 11, 2021
APPL NO 17/399390
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6851 (20130101) Original (OR) Class
G01N 2458/15 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137065 Lim et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) AmberGen, Inc. (Watertown, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Mark J. Lim (Reading, Massachusetts);  Gargey Yagnik (Hopkinton, Massachusetts);  Kenneth J. Rothschild (Newton, Massachusetts)
ABSTRACT The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme).
FILED Wednesday, August 11, 2021
APPL NO 17/399417
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6841 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6851 (20130101) Original (OR) Class
G01N 2458/15 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137066 Lim et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) AmberGen, Inc. (Watertown, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Mark J. Lim (Reading, Massachusetts);  Gargey Yagnik (Hopkinton, Massachusetts);  Kenneth J. Rothschild (Newton, Massachusetts)
ABSTRACT The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme).
FILED Wednesday, August 11, 2021
APPL NO 17/399434
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/6851 (20130101) Original (OR) Class
G01N 2400/00 (20130101)
G01N 2458/15 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138939 Jalali et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Bahram Jalali (Oakland, California);  Madhuri Suthar (Oakland, California);  Cejo Konuparamban Lonappan (Oakland, California);  Antoni Ribas (Oakland, California);  Theodore Scott Nowicki (Oakland, California);  Jia Ming Chen (Oakland, California)
ABSTRACT Systems and methods for digital pathology in accordance with embodiments of the invention obtain a whole slide image of a microscope slide that includes a registration mark, wherein the registration mark is associated with a coordinate system. The method inputs the whole slide image into a region identification (RI) model to extract features of the whole slide image and generate feature vectors for the extracted features, detects a presence of a region of interest (ROI) based on the feature vectors, determines a set of coordinates of the ROI in the coordinate system, and translates a microscope stage of a microscope holding the microscope slide to a position corresponding to the coordinates of the ROI. The method captures a field of view (FOV) image with the microscope and inputs the FOV image into a grading model to determine a pathology score that indicates a likelihood of a presence of a disease.
FILED Friday, February 14, 2020
APPL NO 17/431138
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 21/365 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101) Original (OR) Class
G06T 2207/10056 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30024 (20130101)

Image or Video Recognition or Understanding
G06V 10/25 (20220101)
G06V 10/40 (20220101)
G06V 20/693 (20220101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/40 (20180101)
G16H 30/40 (20180101)
G16H 70/60 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220139497 Kurtz et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
ASSIGNEE(S) The Board of Trustees of the Leland Stanford Junior University (Stanford, California)
INVENTOR(S) David M. Kurtz (San Francisco, California);  Maximilian Diehn (San Carlos, California);  Arash Ash Alizadeh (San Mateo, California)
ABSTRACT Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.
FILED Tuesday, November 16, 2021
APPL NO 17/455209
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/1089 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101)
C12Q 2600/112 (20130101)
C12Q 2600/156 (20130101)

Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology
G16B 20/20 (20190201)
G16B 35/20 (20190201) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Defense (DOD) 

US 20220132839 Riffell et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Organismal Systems (IOS)
APPLICANT(S) UNIVERSITY OF WASHINGTON (Seattle, Washington)
ASSIGNEE(S) UNIVERSITY OF WASHINGTON (Seattle, Washington)
INVENTOR(S) Jeffrey A. Riffell (Seattle, Washington);  Chloé Lahondère (Seattle, Washington);  Clément Vinauger (Seattle, Washington)
ABSTRACT Mosquito attractant composition for attracting a mosquito to a pre-determined location. The composition includes a combination of nonanal and lilac aldehydes.
FILED Thursday, February 20, 2020
APPL NO 17/431869
CURRENT CPC
Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants
A01M 1/2016 (20130101)
A01M 29/12 (20130101)

Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 31/02 (20130101) Original (OR) Class
A01N 31/04 (20130101)
A01N 43/08 (20130101)

Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations
A01P 17/00 (20210801)
A01P 19/00 (20210801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220132971 Matsushita et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Albert Keisuke Matsushita (La Jolla, California);  Luis Garcia (San Diego, California);  Skye Edwards (San Diego, California);  Michael Collins (San Diego, California);  Charles Zahl (San Diego, California)
ABSTRACT A jammer system includes a jammer unit, a valve coupled to the jammer unit, and a sensor coupled to the valve. The jammer unit includes a jammer media and a membrane including an inlet. The membrane is configured to surround the jammer media. The valve is configured to allow a fluid to pass through the inlet of the membrane. The sensor is configured to cause actuation of the valve to evacuate the fluid from an interior of the membrane. The evacuation of the fluid from the interior of the membrane results in stiffening of the jammer media within the membrane.
FILED Monday, November 01, 2021
APPL NO 17/516524
CURRENT CPC
Hats; Head Coverings
A42B 3/046 (20130101) Original (OR) Class
A42B 3/0453 (20130101)
A42B 3/0486 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133639 Thayumanavan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E)
National Security Engineering Center (NSEC)
Federally Funded Research and Development Center (FFRDC)
Operated by MITRE Corporation (MITRE) at Bedford, MA
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
Division of Materials Research (DMR)
Nanoscale Science and Engineering Centers (NSF-NSEC)
APPLICANT(S) University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Sankaran Thayumanavan (Amherst, Massachusetts);  Jiaming Zhuang (Amherst, Massachusetts);  Hui Wang (Sunderland, Massachusetts)
ABSTRACT The invention generally relates to polymer-based nano-structures. More particularly, the invention relates to novel, surface-functionalized, guest-host polymer nano-assemblies and nano-delivery vehicles useful in diverse fields including drug delivery, diagnostics and specialty materials. The nano-assemblies and nano-delivery vehicles of the invention are afforded via simplify and reliable approaches.
FILED Saturday, July 31, 2021
APPL NO 17/390912
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5138 (20130101) Original (OR) Class
A61K 9/5146 (20130101)
A61K 47/6903 (20170801)

Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests
Y10S 977/773 (20130101)
Y10S 977/906 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133730 Zuo et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute on Deafness and Other Communication Disorders (NIDCD)
APPLICANT(S) Ting Therapeutics LLC (Omaha, Nebraska)
ASSIGNEE(S) Ting Therapeutics LLC (Omaha, Nebraska)
INVENTOR(S) Jian Zuo (Omaha, Nebraska);  Tal Teitz (Omaha, Nebraska)
ABSTRACT Method, kit and pharmaceutical compositions using an inhibitor of EGFR signaling for prevention or treatment of hearing loss are described.
FILED Friday, January 21, 2022
APPL NO 17/580755
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/437 (20130101)
A61K 31/506 (20130101)
A61K 31/519 (20130101) Original (OR) Class
A61K 31/4439 (20130101)
A61K 31/4709 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 27/16 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133743 Mustoe et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Development Command (USAMRDC)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Northwestern University (Evanston, Illinois)
ASSIGNEE(S)
INVENTOR(S) Thomas A. Mustoe (Evanston, Illinois);  Robert D. Galiano (Chicago, Illinois);  Seok Jong Hong (Northbrook, Illinois);  Ping Xie (Chicago, Illinois);  Shengxian Jia (Wilmette, Illinois)
ABSTRACT Provided herein are compositions, systems, and methods for treating wounds with the combination of statins and cholesterol to help prevent and reduce scar formation.
FILED Tuesday, July 13, 2021
APPL NO 17/374488
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/06 (20130101)
A61K 9/0014 (20130101)
A61K 9/14 (20130101)
A61K 9/107 (20130101)
A61K 9/1075 (20130101)
A61K 31/22 (20130101)
A61K 31/225 (20130101)
A61K 31/366 (20130101)
A61K 31/575 (20130101) Original (OR) Class
A61K 45/06 (20130101)
A61K 47/10 (20130101)
A61K 47/12 (20130101)
A61K 47/14 (20130101)
A61K 47/44 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 17/02 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133793 LUM et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Development Command (USAMRDC)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Provincial Health Services Authority (Vancouver, Canada);  UNIVERSITÉ LAVAL (Québec, Canada)
ASSIGNEE(S)
INVENTOR(S) Julian J. LUM (Victoria, Canada);  Lindsay DEVORKIN (Burnaby, Canada);  Yannick DOYON (Québec, Canada);  Gillian CARLETON (Victoria, Canada)
ABSTRACT Lymphocytes having a suppressed autophagy gene useful in immunotherapy are disclosed. The lymphocytes can express an antigen targeting receptor such as a chimeric antigen receptor (CAR) or endogenous or engineered T-cell receptor to target cells expressing a tumor-specific antigen. Methods of making and using such lymphocytes are disclosed. Some such lymphocytes are useful in conducting CAR-T or TCR-T therapy.
FILED Wednesday, February 12, 2020
APPL NO 17/430055
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 35/17 (20130101) Original (OR) Class
A61K 38/1774 (20130101)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 35/00 (20180101)

Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids
C07H 21/02 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/907 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220134341 MILLER et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Sinead E. MILLER (Houston, Texas);  Charleson S. BELL (Nashville, Tennessee);  Todd D. GIORGIO (Nashville, Tennessee);  Andrew L. COOK (Antioch, Tennessee)
ABSTRACT The present disclosure relates to a fluidic device to detect, capture, and/or remove disease material in a biological fluid. The present invention also relates to methods for the treatment/prevention of sepsis through the use of the claimed device.
FILED Wednesday, September 01, 2021
APPL NO 17/464103
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 38/12 (20130101)
A61K 38/14 (20130101)

Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor
A61M 5/165 (20130101)

Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502715 (20130101)
B01L 3/502753 (20130101) Original (OR) Class
B01L 3/502776 (20130101)
B01L 2300/16 (20130101)
B01L 2300/0861 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/48 (20130101)
G01N 33/53 (20130101)
G01N 33/543 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220134429 PARSONS
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E)
MIT Lincoln Laboratory (MITLL)
Federally Funded Research and Development Center (FFRDC)
Operated by Massachusetts Institute of Technology (MIT) at Lexington, MA
APPLICANT(S) MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
ASSIGNEE(S) MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts)
INVENTOR(S) Ethan PARSONS (Cambridge, Massachusetts)
ABSTRACT Compositions and methods of making compositions for additive manufacturing of composite powders including metal ceramic alloyed material is described.
FILED Friday, November 05, 2021
APPL NO 17/520134
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 1/05 (20220101)
B22F 9/04 (20130101) Original (OR) Class
B22F 10/28 (20210101)
B22F 2009/041 (20130101)
B22F 2301/052 (20130101)
B22F 2304/10 (20130101)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 40/10 (20200101)
B33Y 70/10 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220134639 Allen et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Sea Systems Command (NAVSEA)
APPLICANT(S) Vadient Optics, LLC (Beaverton, Oregon)
ASSIGNEE(S)
INVENTOR(S) Thomas Leonard Allen (Eugene, Oregon);  John Paul Harmon (Albany, Oregon);  Samuel Peter Grimm (Philomath, Oregon);  George Williams (Vashon, Washington);  Peter George Hugger (Eugene, Oregon)
ABSTRACT An additively manufactured article is assembled from a plurality of printed voxels. The article includes a lattice of unit cells of a composite lattice material and an encasing matrix of structural material arranged between adjacent unit cells of the lattice. The structural material has greater mechanical strength than the composite lattice material.
FILED Friday, January 21, 2022
APPL NO 17/581478
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/112 (20170801) Original (OR) Class
B29C 64/209 (20170801)
B29C 64/245 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 30/00 (20141201)
B33Y 40/20 (20200101)
B33Y 50/02 (20141201)
B33Y 70/00 (20141201)
B33Y 80/00 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135210 Fegely et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Contracting Command (ACC)
Redstone Arsenal (REDSTONE)
APPLICANT(S) Bell Textron Inc. (Fort Worth, Texas)
ASSIGNEE(S)
INVENTOR(S) Cody Fegely (Irving, Texas);  Kenneth Stephen Wittmer (Sandy Hook, Connecticut)
ABSTRACT There is disclosed in one example a flight control computer for a rotary aircraft, including: a first interface to communicatively couple to a flight control input; a second interface to communicatively couple to flight geometry actuators; a data source; a multi-dimensional lookup table including a data structure to correlate flight control inputs to flight geometry actuator outputs according to a third-factor; and circuitry and logic instructions to: receive an input via the first interface; query the data source for the third-factor; query the multi-dimensional lookup table for a control input modifier according to the flight control input and the third-factor; and compute and send via a third interface a flight geometry output according to the control input modifier.
FILED Thursday, October 29, 2020
APPL NO 17/083900
CURRENT CPC
Aeroplanes; Helicopters
B64C 13/503 (20130101) Original (OR) Class
B64C 27/04 (20130101)
B64C 2027/8209 (20130101)

Systems for Controlling or Regulating Non-electric Variables
G05D 1/085 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135237 Jamison
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio)
ASSIGNEE(S)
INVENTOR(S) David Jamison (Luther, Oklahoma)
ABSTRACT Ice detection test apparatuses, systems, and methods are disclosed. In some cases, ice detection and precautionary system shut-down event reduction systems and related methods are provided. The system utilizes a turbine engine ice detection apparatus that includes and engine pressure simulation device, an air moving device, and a first air pressure sensor associated with the engine pressure simulation device. The embodiment further includes an ice monitor controller that receives inputs from the first air pressure sensor and at least one second sensor located adjacent a turbine engine intake. The ice monitor controller performs comparisons of inputs from these sensors against each other and stored values to determine actual icing conditions then generate warnings on a display to an operator. The exemplary control section has multiple modes including manual, semi-manual and automatic.
FILED Monday, October 25, 2021
APPL NO 17/509214
CURRENT CPC
Aeroplanes; Helicopters
B64C 19/00 (20130101)

Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft
B64D 15/20 (20130101) Original (OR) Class

Non-positive Displacement Machines or Engines, e.g Steam Turbines
F01D 21/14 (20130101)
F01D 25/02 (20130101)

Wind Motors
F03D 80/40 (20160501)

Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for
G01K 13/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135423 Hugger et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Surface Warfare Center (NSWC)
APPLICANT(S) Vadient Optics, LLC (Beaverton, Oregon)
ASSIGNEE(S) Vadient Optics, LLC (Beaverton, Oregon)
INVENTOR(S) Peter G Hugger (Eugene, Oregon);  Chad N Teters (Eugene, Oregon);  Thomas L Allen (Eugene, Oregon);  Ernst Adrian Henle (Eugene, Oregon);  Peter J Polesnak (Eugene, Oregon)
ABSTRACT Methods and apparatus for producing a magnetic nanoparticle suitable for additive manufacturing techniques includes providing a solution having a plurality of metallic precursors to produce magnetic nanoparticles, a coordinating solvent, and a chelating agent. The solution is mixed and heated to grow nanoparticles wherein magnetic nanoparticles are formed. The solution is then cooled and a magnetic field is applied to the solution wherein ferrite nanoparticles are at least partially separated by size.
FILED Tuesday, June 23, 2020
APPL NO 16/909533
CURRENT CPC
Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 40/10 (20200101)
B33Y 70/00 (20141201)

Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 49/0063 (20130101) Original (OR) Class

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2004/64 (20130101)
C01P 2006/42 (20130101)

Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor
C09D 11/037 (20130101)
C09D 11/322 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135530 Piercey et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Davin Glenn Piercey (Lafayette, Indiana);  Timothy D. Manship (Zionsville, Indiana);  Dawson Michael Smith (Marana, Arizona)
ABSTRACT This disclosure shows the ability of a readily-available oxidizer to achieve oxidation of 5-amino-1H-tetrazole (5-AT) to 5-nitrotetrazole (5-NT) in high yields in a single pot synthesis. This strategy reduces the synthesis of this important energetic material down to a single step and eliminates highly sensitive diazonium and copper salt primary explosive intermediates. The overall yield of this process is 48-53% and the resultant aqueous solution of product effectively used for the preparation of nitrotetrazole-containing primary explosive DBX-1. Unlike current methods of nitrotetrazole preparation, the novel method is entirely solution-based and prepares a final solution of sodium nitrotetrazolate, never once needing to handle energetic intermediates or products, making it a much safer method of nitrotetrazole preparation.
FILED Monday, April 05, 2021
APPL NO 17/221863
CURRENT CPC
Heterocyclic Compounds
C07D 257/06 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135572 Haystead et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Army Medical Research Acquisition Activity (USAMRAA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
APPLICANT(S) Duke University (Durham, North Carolina)
ASSIGNEE(S)
INVENTOR(S) Timothy A. J. Haystead (Chapel Hill, North Carolina);  Philip Floyd Hughes (Chapel Hill, North Carolina)
ABSTRACT Described herein are compounds that may selectively bind to Hsp90, methods of using the compounds, and kits including the compounds. The compounds may allow for selective detection of Hsp90 in a sample.
FILED Monday, January 10, 2022
APPL NO 17/572222
CURRENT CPC
Heterocyclic Compounds
C07D 403/14 (20130101)
C07D 487/04 (20130101) Original (OR) Class
C07D 491/107 (20130101)
C07D 498/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135654 Goldman et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Research Laboratory (NRL)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia)
ASSIGNEE(S)
INVENTOR(S) Ellen R. Goldman (Germantown, Maryland);  George P. Anderson (Bowie, Maryland);  Jinny L. Liu (Ellicot City, District of Columbia);  Thomas J. Esparza (Frederick, Maryland)
ABSTRACT A number of single domain antibodies (sdAb, also known as nanobodies or VHH) were developed that bind nucleocapsid protein of the SARS-CoV-2 virus. They are useful for detecting the virus and could also find application in therapeutics.
FILED Thursday, October 28, 2021
APPL NO 17/512837
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 2039/507 (20130101)

Peptides
C07K 16/10 (20130101) Original (OR) Class
C07K 16/468 (20130101)
C07K 2317/31 (20130101)
C07K 2317/565 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/563 (20130101)
G01N 33/56983 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135655 Marasco et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
APPLICANT(S) Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Wayne A. Marasco (Wellesley, Massachusetts);  Yuval Avnir (Boston, Massachusetts)
ABSTRACT The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection.
FILED Monday, July 26, 2021
APPL NO 17/385465
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/6841 (20170801)

Peptides
C07K 16/1018 (20130101) Original (OR) Class
C07K 2317/21 (20130101)
C07K 2317/54 (20130101)
C07K 2317/55 (20130101)
C07K 2317/56 (20130101)
C07K 2317/76 (20130101)
C07K 2317/92 (20130101)
C07K 2317/565 (20130101)
C07K 2317/567 (20130101)
C07K 2317/622 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6876 (20130101)
C12Q 2600/106 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5052 (20130101)
G01N 2800/52 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135892 PATEL
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Corps of Engineers (USACE)
Construction Engineering Research Laboratory (CERL)
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S) Nikhil Manubhai PATEL (Grand Forks, North Dakota)
ASSIGNEE(S)
INVENTOR(S) Nikhil Manubhai PATEL (Grand Forks, North Dakota)
ABSTRACT The present invention discloses a gasifier and/or a gasification process that provides a long, uniform temperature zone in the gasifier, regardless of the particle size, chemical composition, and moisture content of the fuel by sandwiching a reduction zones between two oxidation zones. The gasifier and/or gasification process has a char that is more energy-dense and almost devoid of moisture that affords for an additional (or char) oxidation zone with a temperature that is higher than a first oxidation zone which is closer to an evaporation and devolatilization zone. As such, the additional (or char) oxidation zone contributes to augmenting the reduction zone temperature, thereby providing a favorable dual impact in improving syngas composition and near-complete conversion of the tar.
FILED Friday, January 07, 2022
APPL NO 17/570448
CURRENT CPC
Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases
C10J 3/08 (20130101) Original (OR) Class
C10J 3/22 (20130101)
C10J 3/26 (20130101)
C10J 3/723 (20130101)
C10J 2300/092 (20130101)
C10J 2300/093 (20130101)
C10J 2300/0946 (20130101)
C10J 2300/0956 (20130101)
C10J 2300/0959 (20130101)
C10J 2300/0976 (20130101)
C10J 2300/1246 (20130101)

Purifying or Modifying the Chemical Composition of Combustible Gases Containing Carbon Monoxide
C10K 1/024 (20130101)
C10K 1/026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136059 Czyzyk-Krzeska et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Cincinnati (Cincinnati, Ohio)
ASSIGNEE(S) University of Cincinnati (Cincinnati, Ohio)
INVENTOR(S) Maria Franciszka Czyzyk-Krzeska (Cincinnati, Ohio);  Julio Alberto Landero Figueroa (Cincinnati, Ohio);  Jarek Meller (Cincinnati, Ohio);  David Plas (Cincinnati, Ohio);  Shuchi Gulati (Cincinnati, Ohio);  Bhargav Vemuri (Mason, Ohio);  John Thomas Cunningham, IV (Maineville, Ohio)
ABSTRACT A method of diagnosing the likelihood of recurrence of clear cell renal cell carcinoma is provided. The method involves a) detecting the gene expression signatures of mitochondrial electron transport chain subunits, mitochondrial ribosomal proteins, major histocompatibility complex class II (MHC-II) proteins or combinations thereof in a kidney tumor tissue sample; and b) determining that the subject has an elevated risk of recurrence of clear cell renal cell carcinoma if the gene expression signatures include certain sequences. In another embodiment, the method uses copper levels to diagnose the likelihood of recurrence of clear cell renal cell carcinoma.
FILED Friday, May 21, 2021
APPL NO 17/327100
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/118 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57438 (20130101)
G01N 2333/90216 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136119 Flanders et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate of Technology
Translational Impacts (TI)
APPLICANT(S) Opus 12 Incorporated (Berkeley, California)
ASSIGNEE(S)
INVENTOR(S) Nicholas H. Flanders (San Francisco, California);  Kendra P. Kuhl (Oakland, California);  Etosha R. Cave (Berkeley, California);  Sichao Ma (Dublin, California);  Ziyang Huo (Moraga, California);  Carter S. Haines (Berkeley, California);  Timothy A. Bekkedahl (Sunnyvale, California);  Kathryn L. Corp (Berkeley, California);  Ashley D. Mishra (Danville, California);  Edward Izett (Berkeley, California)
ABSTRACT A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition.
FILED Tuesday, August 03, 2021
APPL NO 17/444356
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/08 (20130101)
B01J 20/10 (20130101)
B01J 20/20 (20130101)
B01J 20/3483 (20130101)
B01J 2220/42 (20130101)

Apparatus for Enzymology or Microbiology;
C12M 43/00 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 5/023 (20130101)
C12P 7/06 (20130101)
C12P 7/16 (20130101)
C12P 7/52 (20130101)
C12P 7/54 (20130101)

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 3/03 (20210101)
C25B 3/26 (20210101)
C25B 13/08 (20130101)
C25B 15/081 (20210101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136618 Wehner et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Michael Wehner (Santa Cruz, California);  Keng-Yu Lin (Santa Cruz, California);  Natalie King (Santa Cruz, California)
ABSTRACT A passive microfluidic valve includes a first manifold portion having a first chamber; a first inlet fluidly coupled to the first chamber; and a second inlet. The valve also includes a second manifold portion in fluid communication with the first chamber via a channel. The second manifold portion includes a second chamber fluidly coupled to the first chamber and the second inlet. The valve further includes a flexible membrane disposed between the first manifold portion and the second manifold portion and separating the first chamber and the second chamber, the flexible membrane configured to modulate a flow rate of a media flowing between the first inlet and the second inlet in either direction in response to pressure of the media flow.
FILED Monday, November 01, 2021
APPL NO 17/515792
CURRENT CPC
Microstructural Devices or Systems, e.g Micromechanical Devices
B81B 2201/038 (20130101)
B81B 2201/054 (20130101)

Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating
F16K 99/0015 (20130101) Original (OR) Class
F16K 99/0057 (20130101)
F16K 2099/0082 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136937 Deng et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Morgan State University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Hua Deng (Baltimore, Maryland);  Hongtao Yu (Baltimore, Maryland)
ABSTRACT Fluorescence titration of methylene blue, rhodamine B and rhodamine 6G (R6G) by silver nanoparticle (AgNP) all resulted in an initial steep quenching curve followed with a sharp turn and a much flatter quenching curve. At the turn, there are about 200,000 dye molecules per a single AgNP, signifying self-assembly of approximately 36 layers of dye molecules on the surface of the AgNP to form a micelle-like structure. These fluorescence-quenching curves fit to a mathematical model with an exponential term due to molecular self-assembly on a AgNP surface, or “self-assembly shielding effect”, and a Stern-Volmer term (nanoparticle surface enhanced quenching). Such a “super-quenching” by AgNP can only be attributed to “pre-concentration” of the dye molecules on the nanoparticle surface that yields the formation of micelle-like self-assembly, resulting in great fluorescence quenching. Overall, the fluorescence quenching titration reveals three different types of interactions of dye molecules on AgNP surface: 1) self-assembly (methylene blue, rhodamine B and R6G), 2) absorption/tight interaction (tryptamine and fluorescein), and 3) loose interaction (eosin Y). We attribute the formation of micelle-like self-assembly of these three dye molecules on AgNP to their positive charge, possession of nitrogen atoms, and with relatively large and flat aromatic moieties.
FILED Friday, August 13, 2021
APPL NO 17/401985
CURRENT CPC
Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 62/44 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/06 (20130101)
C09K 2211/1007 (20130101)
C09K 2211/1018 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/30 (20130101) Original (OR) Class
G01N 2001/302 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136986 Motes, III et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
MATERIALS and MANUFACTURING DIRECTORATE (MMD)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Texas Research International, Inc. (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Doyle T. Motes, III (Austin, Texas);  Marcus Keiser (Cedar Park, Texas);  Richard Piner (Austin, Texas)
ABSTRACT Non-destructive sensing methods and devices for inspection and measuring in manufacturing applications for removal of contaminants from composite surfaces coupled with sensing and activation of the composite surfaces.
FILED Friday, September 10, 2021
APPL NO 17/472533
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 23/225 (20130101)
G01N 23/2202 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137017 Lazar et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
INVENTOR(S) Aurel A. Lazar (New York, New York);  Tingkai Liu (Suzhou, China PRC);  Chung-Heng Yeh (Kaohsiung, Taiwan)
ABSTRACT The present disclosure provides, method, a system, and apparatus for identifying odorants. For example, the apparatus performs sensing an odorant using an olfactory sensor, encoding the sensed odorant to an electrical signal using an input processor, determining an identity representation of the odorant based on the encoded electrical signal, and determining odorant information using a time-dependent hash code based on the identity representation of the odorant.
FILED Monday, December 14, 2020
APPL NO 17/121246
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/0031 (20130101) Original (OR) Class
G01N 33/0062 (20130101)
G01N 2033/0068 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6215 (20130101)

Computational Chemistry; Chemoinformatics; Computational Materials Science
G16C 60/00 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137162 Romalis et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
APPLICANT(S) The Trustees of Princeton University (Princeton, New Jersey)
ASSIGNEE(S) The Trustees of Princeton University (Princeton, New Jersey)
INVENTOR(S) Michael Romalis (Princeton, New Jersey);  Nezih Dural (Bordentown, New Jersey);  Vito-Giovanni Lucivero (Barcelona, Spain);  Wonjae Lee (Princeton, New Jersey)
ABSTRACT According to various embodiments, a direct magnetic gradiometer having intrinsic subtraction of rotation signals from two oppositely polarized atomic ensembles within a single multi-pass cell is disclosed. The gradiometer includes three convex spherical mirrors aligned in a V-shape geometry. The three convex spherical mirrors include a front mirror and two back mirrors. The gradiometer further includes a probe laser beam. The laser beam is configured to be initially focused at a near-zero angle into a hole at a center of the front mirror such that the laser beam expands at the back mirrors and nearly overlaps with itself while undergoing multiple reflections between the front and back mirrors. The laser beam is further configured to be refocused to the front mirror at different spots in a number equal to half of total beam passes before exiting.
FILED Friday, November 05, 2021
APPL NO 17/519826
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/26 (20130101) Original (OR) Class

Optical Elements, Systems, or Apparatus
G02B 17/004 (20130101)
G02B 17/0626 (20130101)
G02B 27/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137169 ENGLUND
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Office of Advanced Cyberinfrastructure (OAC)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Dirk Robert ENGLUND (Brookline, Massachusetts)
ABSTRACT Chemical-shift nuclear magnetic resonance (NMR) spectroscopy involves measuring the effects of chemical bonds in a sample on the resonance frequencies of nuclear spins in the sample. Applying a magnetic field to the sample causes the sample nuclei to emit alternating current magnetic fields that can be detected with color centers, which can act as very sensitive magnetometers. Cryogenically cooling the sample increases the sample's polarization, which in turn enhances the NMR signal strength, making it possible to detect net nuclear spins for very small samples. Flash-heating the sample or subjecting it to a magic-angle-spinning magnetic field (instead of a static magnetic field) eliminates built-in magnetic field inhomogeneities, improving measurement sensitivity without degrading the sample polarization. Tens to hundreds of small, cryogenically cooled sample chambers can be integrated in a semiconductor substrate interlaced with waveguides that contain color centers for optically detected magnetic resonance measurements of the samples' chemical-shift NMR frequencies.
FILED Friday, September 03, 2021
APPL NO 17/465895
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/31 (20130101)
G01R 33/46 (20130101) Original (OR) Class
G01R 33/282 (20130101)
G01R 33/323 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137394 Younts et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Information Warfare Center (NIWC)
Naval Information Warfare Center Pacific (NIWCPACIFIC)
APPLICANT(S) United States Government as represented by the Secretary of the Navy (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) Robert Alexander Younts (Moncks Corner, South Carolina);  Tian-Bing Xu (Chesapeake, Virginia);  Laura Catherine Tolliver (Charleston, South Carolina)
ABSTRACT A programmable, deformable incident-energy shaper comprising: a base having top and bottom surfaces with a perforation there-between; a protrusion connected to, and extending outwardly from, a center of the top surface; a deformable layer firmly attached to the base's perimeter and to a tip of the protrusion such that a majority of the deformable layer is suspended in free space between the tip and the perimeter, wherein the deformable layer is configured to flex inwardly or outwardly, and wherein the perforation provides a fluid channel to ambient fluid; and an actuator, operatively coupled to the deformable layer and configured to cause the deformable layer to flex inwardly or outwardly upon command.
FILED Wednesday, November 04, 2020
APPL NO 17/089044
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 26/004 (20130101)
G02B 26/0825 (20130101) Original (OR) Class

Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for
G10K 15/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137484 MITTAL et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Air Force Research Laboratory (AFRL)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Physics (PHY)
APPLICANT(S) University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S) Sunil MITTAL (Rockville, Maryland);  Mohammad HAFEZI (Washington, District of Columbia)
ABSTRACT Examples of the present disclosure include the use of a topological system including an array of coupled ring resonators that exhibits topological edge states to generate frequency combs and temporal dissipative Kerr solitons. The topological edge states constitute a travelling-wave super-ring resonator causing generation of at least coherent nested optical frequency combs, and self-formation of nested temporal solitons that are robust against defects in the array at a mode efficiency exceeding 50%.
FILED Monday, November 01, 2021
APPL NO 17/515757
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/3513 (20130101) Original (OR) Class
G02F 1/3536 (20130101)
G02F 2203/15 (20130101)
G02F 2203/17 (20130101)
G02F 2203/54 (20130101)
G02F 2203/56 (20130101)

Transmission
H04B 10/506 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138233 Ackermann et al.
FUNDED BY
Department of Defense (DOD)
APPLICANT(S) International Business Machines Corporation (Armonk, New York)
ASSIGNEE(S)
INVENTOR(S) Christopher F. Ackermann (Chantilly, Virginia);  Charles E. Beller (Baltimore, Maryland);  Michael Drzewucki (Woodbridge, Virginia)
ABSTRACT A method, system and computer-usable medium are disclosed to identify a set of entity names based on a partial name of the entity utilizing discovered relationships. A partial name from a user is received as to the entity in order to retrieve a plurality of names of the entity in a corpus which can be a body or works, document, etc. References to the entries containing the partial name are retrieved from the corpus. A natural language processing is applied to content associated with references to identify candidate entities. A similarity is performed as to the identified candidate entities to form a similarity assessment, and from the candidate entities a selection is made based on a merging criteria.
FILED Wednesday, November 04, 2020
APPL NO 17/089465
CURRENT CPC
Electric Digital Data Processing
G06F 16/248 (20190101)
G06F 16/288 (20190101) Original (OR) Class
G06F 16/24578 (20190101)
G06F 40/30 (20200101)
G06F 40/284 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138408 Ackermann et al.
FUNDED BY
Department of Defense (DOD)
APPLICANT(S) INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York)
ASSIGNEE(S)
INVENTOR(S) Christopher F. Ackermann (Fairfax, Virginia);  Charles E. Beller (Baltimore, Maryland);  Michael Drzewucki (Woodbridge, Virginia)
ABSTRACT An embodiment for extracting information from semi-structured text is provided. The embodiment may include identifying one or more high confidence alignments of one or more entities and identifiers in a set of documents. The embodiment may also include analyzing one or more blocks of semi-structured text containing the one or more entities and identifiers. The embodiment may further include identifying one or more known alignments in each of the one or more blocks of semi-structured text. The embodiment may also include generating a structure template. The embodiment may further include applying the structure template to each of the one or more blocks of semi-structured text. The embodiment may also include annotating the set of documents with metadata reflecting the structure template and a location of each of the one or more blocks of semi-structured text.
FILED Tuesday, November 03, 2020
APPL NO 17/087994
CURRENT CPC
Electric Digital Data Processing
G06F 16/84 (20190101)
G06F 40/169 (20200101) Original (OR) Class
G06F 40/186 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138472 Mittal et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
APPLICANT(S) University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S) Trisha Mittal (College Park, Maryland);  Uttaran Bhattacharya (College Park, Maryland);  Rohan Chandra (College Park, Maryland);  Aniket Bera (Greenbelt, Maryland);  Dinesh Manocha (Greenbelt, Maryland)
ABSTRACT A video is classified as real or fake by extracting facial features, including facial modalities and facial emotions, and speech features, including speech modalities and speech emotions, from the video. The facial and speech modalities are passed through first and second neural networks, respectively, to generate facial and speech modality embeddings. The facial and speech emotions are passed through third and fourth neural networks, respectively, to generate facial and speech emotion embeddings. A first distance, d1, between the facial modality embedding and the speech modality embedding is generated, together with a second distance, d2, between the facial emotion embedding and the speech emotion embedding. The video is classified as fake if a sum of the first distance and the second distance exceeds a threshold distance. The networks may be trained using real and fake video pairs for multiple subjects.
FILED Monday, November 01, 2021
APPL NO 17/515846
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00302 (20130101)
G06K 9/00718 (20130101) Original (OR) Class
G06K 9/00744 (20130101)
G06K 9/00758 (20130101)
G06K 9/6215 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/08 (20130101)
G06N 3/0454 (20130101)
G06N 3/0481 (20130101)

Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding
G10L 25/30 (20130101)
G10L 25/63 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138608 Ramette et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Physics (PHY)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Joshua Ramette (Cambridge, Massachusetts);  Josiah Sinclair (Cambridge, Massachusetts);  Vladan VULETIC (Cambridge, Massachusetts)
ABSTRACT An all-to-all coupled, high-fidelity, error-correctable quantum computer can scale to hundreds of qubits within a single cavity of moderate cooperativity with existing neutral atom technology. This quantum processor can enact teleported gates among any pair of qubits using a local Rydberg interaction between each qubit and a separate network of atoms that distribute entanglement via a cavity mode. Small atomic ensembles at network nodes allow for ultrafast, nondestructive readout with high fidelity by substantially shifting the resonance of even a poor-quality cavity. Fast readout enables near-deterministic entanglement distribution among network atoms despite cavity losses as well as syndrome measurements of qubit atoms for error correction.
FILED Monday, August 30, 2021
APPL NO 17/460385
CURRENT CPC
Electric Digital Data Processing
G06F 9/30101 (20130101)

Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138652 Simeone et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
APPLICANT(S) Michael P. Simeone (Scottsdale, Arizona);  David Little (Mesa, Arizona);  George Boben (Fort Worth, Texas);  Shashank Kapoor (New Delhi, India);  Deepan Nedumaran (Tempe, Arizona);  Aravind Sundaresan (Tempe, Arizona)
ASSIGNEE(S)
INVENTOR(S) Michael P. Simeone (Scottsdale, Arizona);  David Little (Mesa, Arizona);  George Boben (Fort Worth, Texas);  Shashank Kapoor (New Delhi, India);  Deepan Nedumaran (Tempe, Arizona);  Aravind Sundaresan (Tempe, Arizona)
ABSTRACT A system for failure detection tools is disclosed. The system may include at least one user device, an application server, and a failure detection system, each of which may be in communication with one or more of the others via at least one network. The failure detection system may receive first data from a data source, process the first data to generate second data, apply a statistical modeling algorithm to make a prediction relating to the first data or the second data, and communicate data relating to the prediction and/or a trend related to the first data or the second data to the user device for displaying at least a portion of the data relating to the prediction and/or the trend on a display of the user device.
FILED Thursday, October 28, 2021
APPL NO 17/513533
CURRENT CPC
Electric Digital Data Processing
G06F 9/54 (20130101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/0633 (20130101)
G06Q 10/06312 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138911 NEWEY et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Michael NEWEY (Chelmsford, Massachusetts);  Prafull SHARMA (Cambridge, Massachusetts)
ABSTRACT A neural network is used to remove noise from a data signal. The noise removed by the neural network is compared to simulated noise that represents noise expected to be present in the data signal. The results of the comparison are used to train the neural network and improve its ability to remove noise from the data signal
FILED Friday, November 05, 2021
APPL NO 17/519929
CURRENT CPC
Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves
G01S 17/89 (20130101)

Computer Systems Based on Specific Computational Models
G06N 3/088 (20130101)
G06N 3/0454 (20130101)

Image Data Processing or Generation, in General
G06T 5/002 (20130101) Original (OR) Class
G06T 5/50 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/20224 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138939 Jalali et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Cancer Institute (NCI)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) The Regents of the University of California (Oakland, California)
ASSIGNEE(S) The Regents of the University of California (Oakland, California)
INVENTOR(S) Bahram Jalali (Oakland, California);  Madhuri Suthar (Oakland, California);  Cejo Konuparamban Lonappan (Oakland, California);  Antoni Ribas (Oakland, California);  Theodore Scott Nowicki (Oakland, California);  Jia Ming Chen (Oakland, California)
ABSTRACT Systems and methods for digital pathology in accordance with embodiments of the invention obtain a whole slide image of a microscope slide that includes a registration mark, wherein the registration mark is associated with a coordinate system. The method inputs the whole slide image into a region identification (RI) model to extract features of the whole slide image and generate feature vectors for the extracted features, detects a presence of a region of interest (ROI) based on the feature vectors, determines a set of coordinates of the ROI in the coordinate system, and translates a microscope stage of a microscope holding the microscope slide to a position corresponding to the coordinates of the ROI. The method captures a field of view (FOV) image with the microscope and inputs the FOV image into a grading model to determine a pathology score that indicates a likelihood of a presence of a disease.
FILED Friday, February 14, 2020
APPL NO 17/431138
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 21/365 (20130101)

Image Data Processing or Generation, in General
G06T 7/0012 (20130101) Original (OR) Class
G06T 2207/10056 (20130101)
G06T 2207/20081 (20130101)
G06T 2207/20084 (20130101)
G06T 2207/30024 (20130101)

Image or Video Recognition or Understanding
G06V 10/25 (20220101)
G06V 10/40 (20220101)
G06V 20/693 (20220101)

Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data
G16H 10/40 (20180101)
G16H 30/40 (20180101)
G16H 70/60 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220139031 Young et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
U.S. Army Contracting Command (ACC)
Redstone Arsenal (REDSTONE)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
Department of Transportation (USDOT)
Federal Highway Administration (FHWA)
National Highway Traffic Safety Administration (NHTSA)
APPLICANT(S) TRX Systems, Inc. (Greenbelt, Maryland)
ASSIGNEE(S)
INVENTOR(S) Travis Young (Rockville, Maryland);  Daniel Hakim (Silver Spring, Maryland);  Daniel Franchy (Catonsville, Maryland);  Jared Napora (Severn, Maryland);  John Karvounis (Bowie, Maryland);  Jonathan Fetter Degges (Washington, District of Columbia);  Tim Wang (Germantown, Maryland);  Benjamin Funk (Hanover, Maryland);  Carole Teolis (Glendale, Maryland);  Carol Politi (Bethesda, Maryland);  Stuart Woodbury (Ellicott City, Maryland)
ABSTRACT Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device.
FILED Wednesday, September 15, 2021
APPL NO 17/475935
CURRENT CPC
Electric Digital Data Processing
G06F 30/13 (20200101)

Image Data Processing or Generation, in General
G06T 17/05 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220139077 Bushmitch et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
APPLICANT(S) The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Dennis Bushmitch (Somerset, New Jersey);  Michael Badger (Ocean Grove, New Jersey)
ABSTRACT Various embodiments associated with a composite image are described. In one embodiment, a handheld device comprises a launch component configured to cause a launch of a projectile. The projectile is configured to capture a plurality of images. Individual images of the plurality of images are of different segments of an area. The system also comprises an image stitch component configured to stitch the plurality of images into a composite image. The composite image is of a higher resolution than a resolution of individual images of the plurality of images.
FILED Thursday, January 20, 2022
APPL NO 17/579712
CURRENT CPC
Aeroplanes; Helicopters
B64C 39/024 (20130101)
B64C 2201/123 (20130101)

Image Data Processing or Generation, in General
G06T 3/4038 (20130101)
G06T 3/4053 (20130101)
G06T 5/50 (20130101)
G06T 7/33 (20170101)
G06T 7/38 (20170101)
G06T 11/60 (20130101)
G06T 2207/10032 (20130101)
G06T 2207/30181 (20130101)
G06T 2207/30212 (20130101)

Image or Video Recognition or Understanding
G06V 10/16 (20220101)
G06V 20/13 (20220101) Original (OR) Class
G06V 20/52 (20220101)

Pictorial Communication, e.g Television
H04N 5/28 (20130101)
H04N 5/2624 (20130101)
H04N 5/23238 (20130101)
H04N 5/23293 (20130101)
H04N 7/185 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220139687 Campbell et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
APPLICANT(S) Spark Thermionics, Inc. (Berkeley, California);  The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Matthew Campbell (Philadelphia, Pennsylvania);  Mohsen Azadi (Philadelphia, Pennsylvania);  Kyana Van Houten (Berkeley, California);  Jared William Schwede (Berkeley, California);  Samuel M. Nicaise (Philadelphia, Pennsylvania);  Igor Bargatin (Wynnewood, Pennsylvania)
ABSTRACT A small-gap device system, preferably including two or more electrodes and one or more spacers maintaining a gap between two or more of the electrodes. A spacer for a small-gap device system, preferably including a plurality of legs defining a mesh structure. A method of spacer and/or small-gap device fabrication, preferably including: defining lateral features, depositing spacer material, selectively removing spacer material, separating the spacer from a fabrication substrate, and/or assembling the small-gap device.
FILED Friday, January 22, 2021
APPL NO 17/155638
CURRENT CPC
Electric Discharge Tubes or Discharge Lamps
H01J 45/00 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140330 Atwater et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Aberdeen Proving Ground (APG)
APPLICANT(S) United States Government, as represented by the Secretary of the Army (Aberdeen Proving Ground, Maryland)
ASSIGNEE(S)
INVENTOR(S) Terrill B. Atwater (Bel Air, Maryland);  Matthew A. Limpert (Kennett Square, Pennsylvania);  Ashley L. Ruth (Bel Air, Maryland);  Paula C. Latorre (Bel Air, Maryland)
ABSTRACT A process for preparing a cathode material comprising a compound of the form LiaMn1-x-zFexNizO2-dCld is provided. In addition, a LiaMn1-x-zFexNizO2-dCld cathode material for electrochemical systems is provided. Furthermore, a lithium or lithium-ion rechargeable electrochemical cell is provided, incorporating the LiaMn1-x-zFexNizO2-dCld cathode material in a positive electrode.
FILED Wednesday, January 12, 2022
APPL NO 17/574496
CURRENT CPC
Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 53/006 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/50 (20130101)
C01P 2002/72 (20130101)
C01P 2002/85 (20130101)
C01P 2006/40 (20130101)

Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy
H01M 4/505 (20130101) Original (OR) Class
H01M 4/525 (20130101)
H01M 10/0525 (20130101)
H01M 2004/028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140463 Schuster et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) THE UNIVERSITY OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) David Schuster (Chicago, Illinois);  Aziza Suleymanzade (Cambridge, Massachusetts);  Jonathan Simon (Chicago, Illinois);  Alexander Anferov (Chicago, Illinois)
ABSTRACT A millimeter-wave resonator is produced by drilling a plurality of holes into a piece of metal. Each hole forms an evanescent tube having a lowest cutoff frequency. The holes spatially intersect to form a seamless three-dimensional cavity whose fundamental cavity mode has a resonant frequency that is less than the cutoff frequencies of all the evanescent tubes. Below cutoff, the fundamental cavity mode does not couple to the waveguide modes, and therefore has a high internal Q. Millimeter waves can be coupled into any of the tubes to excite an evanescent mode that couples to the fundamental cavity mode. The tubes also provide spatial and optical access for transporting atoms into the cavity, where they can be trapped while spatially overlapping the fundamental cavity mode. The piece of metal may be superconducting, allowing the resonator to be used in a cryogenic environment for quantum computing and information processing.
FILED Thursday, October 28, 2021
APPL NO 17/452654
CURRENT CPC
Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type
H01P 7/04 (20130101) Original (OR) Class
H01P 11/008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140492 Huggers et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
APPLICANT(S) Vadient Optics LLC (Beaverton, Oregon)
ASSIGNEE(S) Vadient Optics LLC (Beaverton, Oregon)
INVENTOR(S) Peter G. Huggers (Eugene, Oregon);  Chad N. Teters (Oregon City, Oregon);  Ernst Adrian Henle (Eugene, Oregon);  Thomas Leonard Allen (Milwaukie, Oregon);  John Paul Harmon (Albany, Oregon);  Samuel Peter Grimm (Philomath, Oregon);  Edward Whitney Eliott, III (Eugene, Oregon);  Peter Jon Polesnak (Eugene, Oregon)
ABSTRACT A method of additively manufacturing a composite article with tuned impedance and refractive-index in three dimensions. The method includes providing a ferrite feedstock. The ferrite feedstock is loaded with ferrite particles. The method further includes depositing and curing the ferrite feedstock. Therein a composite article is formed.
FILED Wednesday, June 12, 2019
APPL NO 16/439493
CURRENT CPC
Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)
B33Y 70/10 (20200101)
B33Y 80/00 (20141201)

Antennas, i.e Radio Aerials
H01Q 15/02 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220141248 VELA et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
APPLICANT(S) Booz Allen Hamilton Inc. (McLean, Virginia)
ASSIGNEE(S) Booz Allen Hamilton Inc. (McLean, Virginia)
INVENTOR(S) Chelsea VELA (San Antonio, Texas);  Justin HOFFMAN (Boerne, Texas)
ABSTRACT A system for generating a cyber-attack to penetrate a network. The system includes an identification module configured to identify at least one vulnerability of the network by examining at least one of a node of the network, data transmission within the network, or data received from a cyber defense mechanism; a generation module configured to generate a cyber-attack based on the at least one vulnerability of the network, and a goal to be achieved by the cyber-attack. The system includes a penetration module configured to penetrate the network with the cyber-attack and determine an effectiveness rating of the penetration; and a feedback module configured to provide a feedback to the identification module based on at least the effectiveness rating of the penetration.
FILED Friday, January 14, 2022
APPL NO 17/575917
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 63/1416 (20130101)
H04L 63/1433 (20130101) Original (OR) Class
H04L 63/1466 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220141821 D'ORO et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Salvatore D'ORO (Allston, Massachusetts);  Francesco RESTUCCIA (Boston, Massachusetts);  Tommaso MELODIA (Newton, Massachusetts)
ABSTRACT Methods and systems for allocating radio access network (RAN) spectrum resources among a plurality of mobile virtual network operators (MVNOs) of a network of base stations. The methods and systems include determining a slicing enforcement policy that assigns resource blocks (RBs) of frequency units and time slots of spectrum resources to each MVNO according to a slicing policy in which each MVNO is allocated an amount of the spectrum resources on at least one base station in a determined time span. The slicing enforcement policy minimizes overlap between each MVNO's set of RBs with another MVNO's set of RBs on a same base station, and interference between each MVNO's set of RBs with another MVNO's set of RBs on an interfering base station.
FILED Friday, January 24, 2020
APPL NO 17/424522
CURRENT CPC
Wireless Communication Networks
H04W 16/10 (20130101)
H04W 16/14 (20130101)
H04W 48/18 (20130101)
H04W 72/0453 (20130101) Original (OR) Class
H04W 84/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220142004 Griffin et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Naval Air Systems Command (NAVAIR)
APPLICANT(S) BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
ASSIGNEE(S) BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire)
INVENTOR(S) Jonathan C. Griffin (Westford, Massachusetts);  Ross T. Johnson (Nashua, New Hampshire);  Gregory J. Wunsch (Milford, New Hampshire)
ABSTRACT A heat dissipation structure is disclosed that is especially well-suited for use on aerodynamic systems. The heat dissipation structure is formed within a metallic body that surrounds the heat-generating electronics. The heat dissipation structure is designed to both dissipate the generated heat and also to isolate RF cross-talk between the one or more transmitters and receivers. The heat dissipation structure includes a plurality of ring structures that extend around at least a portion of a body that houses the one or more heat-generating electrical components. The plurality of ring structures may be recessed into the body, and a first spacing between a first adjacent pair of ring structures of the plurality of ring structures is different from a second spacing between a second adjacent pair of ring structures of the plurality of ring structures.
FILED Thursday, November 05, 2020
APPL NO 17/090341
CURRENT CPC
Weapon Sights; Aiming
F41G 7/224 (20130101)
F41G 7/2246 (20130101)

Transmission
H04B 15/02 (20130101)

Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components
H05K 7/20418 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

National Science Foundation (NSF) 

US 20220132835 Bischof et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) John C. Bischof (St. Paul, Minnesota);  Michael L. Etheridge (St. Louis Park, Minnesota);  Jeunghwan Choi (Winterville, North Carolina)
ABSTRACT This disclosure describes compositions and methods related to cryoprotection of biomaterial. Generally, the cryoprotective composition includes a cryoprotective agent and magnetic nanoparticles effective for thawing a cryopreserved specimen comprising biomaterial with minimal biomaterial damage. In some embodiments, the composition is effective for thawing a cryopreserved specimen having a minimum dimension of 0.1 mm. Generally, the method includes obtaining a biomaterial cryopreserved with a cryoprotective composition as summarized above, then subjecting the cryopreserved biomaterial to electromagnetic energy of an intensity sufficient to excite the magnetic nanoparticles and thaw the biomaterial.
FILED Wednesday, January 19, 2022
APPL NO 17/579369
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 1/0221 (20130101) Original (OR) Class
A01N 1/0242 (20130101)
A01N 1/0284 (20130101)
A01N 1/0294 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 13/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220132839 Riffell et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Integrative Organismal Systems (IOS)
APPLICANT(S) UNIVERSITY OF WASHINGTON (Seattle, Washington)
ASSIGNEE(S) UNIVERSITY OF WASHINGTON (Seattle, Washington)
INVENTOR(S) Jeffrey A. Riffell (Seattle, Washington);  Chloé Lahondère (Seattle, Washington);  Clément Vinauger (Seattle, Washington)
ABSTRACT Mosquito attractant composition for attracting a mosquito to a pre-determined location. The composition includes a combination of nonanal and lilac aldehydes.
FILED Thursday, February 20, 2020
APPL NO 17/431869
CURRENT CPC
Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants
A01M 1/2016 (20130101)
A01M 29/12 (20130101)

Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 31/02 (20130101) Original (OR) Class
A01N 31/04 (20130101)
A01N 43/08 (20130101)

Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations
A01P 17/00 (20210801)
A01P 19/00 (20210801)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220132880 DiMaio et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Directorate of Technology
Translational Impacts (TI)
APPLICANT(S) Epogee, LLC (Indianapolis, Indiana)
ASSIGNEE(S) Epogee, LLC (Indianapolis, Indiana)
INVENTOR(S) Jeffrey R. DiMaio (Pendleton, South Carolina);  Peter Gennaro (Mount Pleasant, South Carolina);  Zach Hunt (Simpsonville, South Carolina)
ABSTRACT Certain characteristics of esterified propoxylated glycerol compositions and reduced-fat food products prepared therefrom may be modified and improved by combining such esterified propoxylated glycerol compositions with particular triglyceride compositions having higher melting points, wherein the melting and crystallization properties of each component are taken into account when selecting them for combination. For instance, EPG-based confectionary products having reduced issues with slump, blocking and demolding may be prepared by incorporating such a higher melting triglyceride composition, without compromising the organoleptic qualities of the resulting confectionary.
FILED Wednesday, November 10, 2021
APPL NO 17/454330
CURRENT CPC
Edible Oils or Fats, e.g Margarines, Shortenings, Cooking Oils
A23D 7/003 (20130101) Original (OR) Class

Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General
A23L 29/04 (20160801)

Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages
A23V 2002/00 (20130101)
A23V 2200/232 (20130101)
A23V 2250/1944 (20130101)
A23V 2250/1946 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220132891 Sheth et al.
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology
Translational Impacts (TI)
APPLICANT(S) Imvela Corp. (Brooklyn, New York)
ASSIGNEE(S) Imvela Corp. (Brooklyn, New York)
INVENTOR(S) Ravi Sheth (Brooklyn, New York);  Kendall Dabaghi (Brooklyn, New York);  Felix Ekness (Brooklyn, New York);  Miriam Shiffman (Pittsburgh, Pennsylvania)
ABSTRACT Provided herein are fermented beverages comprising symbiotic microbial communities, and methods of production thereof.
FILED Friday, October 29, 2021
APPL NO 17/515358
CURRENT CPC
Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General
A23L 2/382 (20130101) Original (OR) Class
A23L 33/135 (20160801)

Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages
A23V 2002/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133159 Ansari et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan)
ASSIGNEE(S)
INVENTOR(S) Sardar Ansari (Ypsilanti, Michigan);  Kenn Oldham (Ann Arbor, Michigan);  Kevin R. Ward (Superior Township, Michigan);  Kayvan Najarian (Northville, Michigan);  Lu Wang (Ann Arbor, Michigan)
ABSTRACT A method for noninvasively measuring hemodynamic variables of a person includes physically configuring a sensor to measure the pulse of a person. The sensor generates a pulse waveform indicative of the pulse of the person. A processor obtains the pulse waveform from the sensor and the processor determines a reflection coefficient and reflection delay between an incident and a reflected wave, from which the processor determines the hemodynamic variables of the person from the reflection coefficient and the reflection delay.
FILED Friday, October 29, 2021
APPL NO 17/514939
CURRENT CPC
Diagnosis; Surgery; Identification
A61B 5/02116 (20130101) Original (OR) Class
A61B 5/02125 (20130101)
A61B 5/6819 (20130101)
A61B 5/6822 (20130101)
A61B 5/6823 (20130101)
A61B 5/6824 (20130101)
A61B 5/6826 (20130101)
A61B 5/6828 (20130101)
A61B 5/6829 (20130101)
A61B 5/6831 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133639 Thayumanavan et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
Office of the Under Secretary of Defense for Research and Engineering (OUSD R&E)
National Security Engineering Center (NSEC)
Federally Funded Research and Development Center (FFRDC)
Operated by MITRE Corporation (MITRE) at Bedford, MA
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
Division of Materials Research (DMR)
Nanoscale Science and Engineering Centers (NSF-NSEC)
APPLICANT(S) University of Massachusetts (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Sankaran Thayumanavan (Amherst, Massachusetts);  Jiaming Zhuang (Amherst, Massachusetts);  Hui Wang (Sunderland, Massachusetts)
ABSTRACT The invention generally relates to polymer-based nano-structures. More particularly, the invention relates to novel, surface-functionalized, guest-host polymer nano-assemblies and nano-delivery vehicles useful in diverse fields including drug delivery, diagnostics and specialty materials. The nano-assemblies and nano-delivery vehicles of the invention are afforded via simplify and reliable approaches.
FILED Saturday, July 31, 2021
APPL NO 17/390912
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 9/5138 (20130101) Original (OR) Class
A61K 9/5146 (20130101)
A61K 47/6903 (20170801)

Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests
Y10S 977/773 (20130101)
Y10S 977/906 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220133893 Chen et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) University of Connecticut (Farmington, Connecticut)
ASSIGNEE(S)
INVENTOR(S) Yupeng Chen (Farmington, Connecticut);  Jinhyung Lee (Farmington, Connecticut)
ABSTRACT Disclosed herein is a delivery vehicle based on DNA-inspired Janus based nanotubes (JBNTs) for anti-viral treatment. The nanoparticles (NPs) are based the JBNTs conjugated with targeting moieties such as small molecules, aptamers, and peptides.
FILED Friday, October 29, 2021
APPL NO 17/514390
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/51 (20130101)
A61K 31/194 (20130101)
A61K 31/519 (20130101)
A61K 31/721 (20130101)
A61K 31/722 (20130101)
A61K 31/727 (20130101)
A61K 31/728 (20130101)
A61K 38/19 (20130101)
A61K 38/40 (20130101)
A61K 38/363 (20130101)
A61K 38/385 (20130101)
A61K 47/65 (20170801)
A61K 47/545 (20170801) Original (OR) Class
A61K 47/6929 (20170801)

Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations
A61P 31/12 (20180101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220134337 Aksimentiev
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
ASSIGNEE(S) THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois)
INVENTOR(S) Aleksei Aksimentiev (Urbana, Illinois)
ABSTRACT Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane, wherein the membrane has a first side and a second side, wherein the membrane has a first pore disposed therein, wherein the first pore extends through the membrane from the first side of the membrane to the second side of the membrane, wherein the membrane has a second pore disposed therein, and wherein the second pore extends through the membrane from the first side of the membrane to the second side of the membrane; a first channel disposed on the first side of the membrane, wherein the first channel is along a first longitudinal axis; a second channel disposed on the first side of the membrane, wherein the second channel is along a second longitudinal axis, and wherein the first channel and the second channel are disposed side by side adjacent to each other; a third channel disposed on the second side of the membrane, wherein the third channel is along a third longitudinal axis, wherein the third channel is in first fluid communication with the first channel via the first pore, and wherein the third channel is in second fluid communication with the second channel via the second pore; and one or more sensors disposed at one or more locations to facilitate sequencing of a molecule that extends from the first channel, through the first pore across at least a portion of the third channel, and through the second pore into the second channel. Additional embodiments are disclosed.
FILED Thursday, October 28, 2021
APPL NO 17/513516
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/502715 (20130101) Original (OR) Class
B01L 2200/0652 (20130101)
B01L 2300/0663 (20130101)
B01L 2300/0896 (20130101)
B01L 2400/0415 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6869 (20130101)
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US 20220134340 Tu et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) The Texas A and M University System (College Station, Texas)
ASSIGNEE(S) The Texas A and M University System (College Station, Texas)
INVENTOR(S) Dandan Tu (College Station, Texas);  Gerard L. Coté (College Station, Texas);  Samuel Mabbott (College Station, Texas);  John Dean (College Station, Texas)
ABSTRACT In an embodiment, the present disclosure pertains to a microfluidic device composed of a substrate having an inlet region and a first storage region, a fluid transporting channel in fluid communication with the inlet region, an expandable component in fluid communication with the fluid transporting channel and coupled to a movable arm, and a fluid transporting region coupled to the movable arm and operable to be moved in a horizontal direction to the fluid transporting channel to thereby form fluidic contact between the inlet region and the first storage region upon expansion of the expandable component. In an additional embodiment, the present disclosure pertains to a method of fluid flow utilizing a microfluidic device of the present disclosure.
FILED Thursday, October 28, 2021
APPL NO 17/512787
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/567 (20130101)
B01L 3/50273 (20130101)
B01L 3/502707 (20130101)
B01L 3/502746 (20130101) Original (OR) Class
B01L 2300/126 (20130101)
B01L 2300/0816 (20130101)
B01L 2400/06 (20130101)
B01L 2400/0677 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/115 (20130101)
C12N 2310/16 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/658 (20130101)
G01N 33/5308 (20130101)
G01N 33/6893 (20130101)
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US 20220135412 Waterman et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Vermont and State Agricultural College (Burlington, Vermont)
ASSIGNEE(S)
INVENTOR(S) Rory Waterman (Burlington, Vermont);  Brandon Ackley (Burlington, Vermont)
ABSTRACT Methods of making a ceramic of a Group 13-15 type or a Group 13-15-16 type by thermolyzing a discrete molecular precursor to the ceramic in an oxygen-containing atmosphere. In some embodiments, the discrete molecular precursor is bench-stable and comprises a Lewis acid-base pair or small cyclic compound containing at last one Group 13 element and at least one Group 15 element but does not include indium and phosphorus in combination with one another unless a Group 16 element is present. The thermolysis can be carried out in air, at atmospheric pressure, and at a temperature below about 400° C., if desired. In some embodiments, the discrete molecular precursor can be placed in a mold having a desired shape and the thermolysis performed while the discrete molecular precursor is in the mold so as to produce a ceramic product having the desired shape.
FILED Tuesday, February 11, 2020
APPL NO 17/433276
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 25/087 (20130101)
C01B 35/04 (20130101)
C01B 35/14 (20130101) Original (OR) Class

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/88 (20130101)
C01P 2004/03 (20130101)
C01P 2006/40 (20130101)
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US 20220135413 Hamers et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Wisconsin Alumni Research Foundation (Madison, Wisconsin)
ASSIGNEE(S)
INVENTOR(S) Robert Hamers (Madison, Wisconsin);  Benjamin Bachman (Madison, Wisconsin)
ABSTRACT Improved methods of synthesizing ammonia from hydrogen sulfide and lithium nitrate are disclosed. Specifically, in a continuous cycle, hydrogen sulfide reactant is regenerated from the elemental sulfur that is extracted from a product of the ammonia synthesis, and the regenerated hydrogen sulfide is fed back into the ammonia synthesis reaction. The cycle that regenerates the hydrogen sulfide uses either a water-containing or a water and carbon-containing feedstock to facilitate the regeneration of the hydrogen sulfide from the elemental sulfur.
FILED Friday, October 29, 2021
APPL NO 17/514956
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 19/245 (20130101)
B01J 19/2445 (20130101)
B01J 19/2465 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 17/74 (20130101)

Ammonia; Cyanogen; Compounds Thereof
C01C 1/026 (20130101) Original (OR) Class

Acyclic or Carbocyclic Compounds
C07C 273/10 (20130101)
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US 20220135604 Koide
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania)
ASSIGNEE(S)
INVENTOR(S) Kazunori Koide (Pittsburgh, Pennsylvania)
ABSTRACT Provided herein is a fluorogenic probe that selectively undergoes a [2,3]-sigmatropic rearrangement (seleno-Mislow-Evans rearrangement) with H2O2, followed by an acetal hydrolysis, to produce a green fluorescent molecule in seconds. Also provided herein is a method of identifying or visualizing the presence of H2O2 in a cell, tissue, organ, or organism that includes contacting the cell, tissue, organ, or organism with the fluorogenic probe. Also provided herein is a method of identifying or quantifying the presence of H2O2 in a sample that includes adding to or mixing in the sample the fluorogenic probe.
FILED Friday, October 29, 2021
APPL NO 17/514356
CURRENT CPC
Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium
C07F 11/00 (20130101) Original (OR) Class

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/643 (20130101)
G01N 33/84 (20130101)
G01N 2021/6439 (20130101)
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US 20220135709 Veige et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INCORPORATED (Gainesville, Florida)
ASSIGNEE(S)
INVENTOR(S) Adam S. Veige (Gainesville, Florida);  Chrisropher D. Roland (Danville, California)
ABSTRACT Provided herein are complexes for polymerization of linear alkynes to cyclic poly(alkynes), and methods of making and using same. For example, provided herein are compounds of formula (I) or formula (IV):
FILED Tuesday, March 03, 2020
APPL NO 17/436420
CURRENT CPC
Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds
C08F 4/78 (20130101) Original (OR) Class
C08F 8/04 (20130101)
C08F 38/00 (20130101)
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US 20220135923 Kim et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) University of Georgia Research Foundation, Inc. (Athens, Georgia)
ASSIGNEE(S)
INVENTOR(S) Yongwook Kim (Athens, Georgia);  Amine Laradji (St. Louis, Missouri);  Sergiy Minko (Athens, Georgia);  Nataraja Sekhar Yadavalli (Athens, Georgia)
ABSTRACT Dynamic polymer surfaces are provided that include alternating micropatterns of adhesive domains and environmental stimuli-responsive repulsive domains, where application of a select environmental stimulus activates polymer structures of the repulsive domains to change conformation with respect to the adhesive domains. The dynamic polymer surfaces are useful for sorting, screening, and enriching target particles (such as cells) in a sample and for culturing and harvesting cells. Products, such as cell culture systems, including the dynamic polymer surfaces are also provided.
FILED Friday, October 29, 2021
APPL NO 17/514795
CURRENT CPC
Compositions of Macromolecular Compounds
C08L 33/26 (20130101)

Apparatus for Enzymology or Microbiology;
C12M 23/12 (20130101)
C12M 25/08 (20130101) Original (OR) Class
C12M 33/00 (20130101)
C12M 35/02 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 1/02 (20130101)
C12N 1/04 (20130101)
C12N 2513/00 (20130101)
C12N 2529/00 (20130101)
C12N 2533/30 (20130101)
C12N 2535/10 (20130101)
C12N 2539/10 (20130101)

Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor;
G03F 7/38 (20130101)
G03F 7/162 (20130101)
G03F 7/325 (20130101)
G03F 7/0382 (20130101)
G03F 7/2004 (20130101)
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US 20220135925 Reiserer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
National Institute of Child Health and Human Development (NICHD)
National Institute of Neurological Disorders and Stroke (NINDS)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Ronald S. Reiserer (Nashville, Tennessee);  Gregory B. Gerken (Nashville, Tennessee);  David K. Schaffer (Nashville, Tennessee);  John P. Wikswo (Brentwood, Tennessee)
ABSTRACT A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes.
FILED Wednesday, January 19, 2022
APPL NO 17/578966
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 23/08 (20130101)
C12M 23/10 (20130101)
C12M 23/12 (20130101)
C12M 23/16 (20130101)
C12M 23/50 (20130101)
C12M 23/58 (20130101)
C12M 27/02 (20130101)
C12M 27/12 (20130101)
C12M 29/10 (20130101) Original (OR) Class
C12M 35/02 (20130101)
C12M 35/04 (20130101)
C12M 41/48 (20130101)
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US 20220135953 Lippmann et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Vanderbilt University (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Ethan S. Lippmann (Nashville, Tennessee);  Kylie Balotin (Nashville, Tennessee);  Brian O'Grady (Nashville, Tennessee);  Leon M. Bellan (Nashville, Tennessee)
ABSTRACT Provided are biomaterials useful for cell culture, method of preparation thereof, and use thereof. The present biomaterial comprises a crosslinked hydrogel and a peptide chemically attached to the hydrogel, wherein the peptide comprises a histidine-alanine-valine (HAV) sequence. In particular, the present biomaterial may be useful for culturing neurons, brain endothelial cells, and/or glial cells, supporting the formation of synaptically connected neural networks, and growing stem cell-derived organoids that more closely resemble human organs.
FILED Friday, February 21, 2020
APPL NO 17/429540
CURRENT CPC
Derivatives of Natural Macromolecular Compounds
C08H 1/06 (20130101)

Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 3/24 (20130101)
C08J 3/075 (20130101)
C08J 2389/06 (20130101)

Compositions of Macromolecular Compounds
C08L 89/06 (20130101)
C08L 2312/00 (20130101)

Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 5/0619 (20130101)
C12N 5/0622 (20130101)
C12N 5/0691 (20130101)
C12N 5/0697 (20130101) Original (OR) Class
C12N 2502/081 (20130101)
C12N 2502/086 (20130101)
C12N 2506/45 (20130101)
C12N 2513/00 (20130101)
C12N 2533/54 (20130101)
C12N 2537/10 (20130101)
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US 20220135997 SCHULTINK et al.
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology
Translational Impacts (TI)
APPLICANT(S) Fortiphyte, Inc. (Berkeley, California)
ASSIGNEE(S)
INVENTOR(S) Alexander Christiaan SCHULTINK (Berkeley, California);  Laura A. WETZEL (Berkeley, California)
ABSTRACT The present disclosure provides an isolated, recombinant, or synthetic polynucleotide comprising a FIT1 protein, and homologs, fragments, and variations thereof. The disclosure further relates to transgenic plants, plant parts, and plant cells comprising one or more of these polynucleotides, and exhibit resistance or tolerance to a pathogen, such as Phakopsora pachyrhizi. The disclosure further relates to methods of genetically engineering a pathogen resistance or tolerance trait in a plant, plant part, or plant cell, comprising targeted gene editing of a FIT1 homolog, and plants produced therefrom. The disclosure further relates to methods for identifying new functional FIT1 genes and/or alleles thereof.
FILED Wednesday, October 27, 2021
APPL NO 17/512329
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 15/111 (20130101)
C12N 15/902 (20130101)
C12N 15/8282 (20130101) Original (OR) Class
C12N 2310/20 (20170501)
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US 20220136092 Rajagopalan et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) Jagannathan Rajagopalan (Tempe, Arizona);  Paul Rasmussen (Tempe, Arizona)
ASSIGNEE(S)
INVENTOR(S) Jagannathan Rajagopalan (Tempe, Arizona);  Paul Rasmussen (Tempe, Arizona)
ABSTRACT Methods for controlled microstructure creation utilize seeding of amorphous layers prior to annealing. Seed crystals are formed on an amorphous layer or layers. The material, size, and spacing of the seed crystals may be varied, and multiple seed layers and/or amorphous layers may be utilized. Thereafter, the resulting assembly is annealed to generate a crystalline microstructure. Via use of these methods, devices having desirable microstructural properties are enabled.
FILED Wednesday, August 18, 2021
APPL NO 17/405194
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 14/024 (20130101) Original (OR) Class
C23C 14/5806 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136119 Flanders et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate of Technology
Translational Impacts (TI)
APPLICANT(S) Opus 12 Incorporated (Berkeley, California)
ASSIGNEE(S)
INVENTOR(S) Nicholas H. Flanders (San Francisco, California);  Kendra P. Kuhl (Oakland, California);  Etosha R. Cave (Berkeley, California);  Sichao Ma (Dublin, California);  Ziyang Huo (Moraga, California);  Carter S. Haines (Berkeley, California);  Timothy A. Bekkedahl (Sunnyvale, California);  Kathryn L. Corp (Berkeley, California);  Ashley D. Mishra (Danville, California);  Edward Izett (Berkeley, California)
ABSTRACT A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition.
FILED Tuesday, August 03, 2021
APPL NO 17/444356
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/08 (20130101)
B01J 20/10 (20130101)
B01J 20/20 (20130101)
B01J 20/3483 (20130101)
B01J 2220/42 (20130101)

Apparatus for Enzymology or Microbiology;
C12M 43/00 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 5/023 (20130101)
C12P 7/06 (20130101)
C12P 7/16 (20130101)
C12P 7/52 (20130101)
C12P 7/54 (20130101)

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 3/03 (20210101)
C25B 3/26 (20210101)
C25B 13/08 (20130101)
C25B 15/081 (20210101) Original (OR) Class
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US 20220136133 SINGH et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California (UC BERKELEY) at Berkeley, CA
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) THE UNIVERSITY OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Manish SINGH (Chicago, Illinois);  Tian ZHONG (Chicago, Illinois);  Supratik GUHA (Chicago, Illinois)
ABSTRACT The present disclosure includes a thin film assembly comprising a substrate and an epitaxial crystalline thin film disposed on the substrate, wherein the epitaxial crystalline thin film is a single crystal, wherein at least a portion of the epitaxial crystalline thin film is doped with rare-earth ions at a concentration of less than 100 parts per billion. The disclosure further includes a method of manufacturing a thin film assembly, the method comprising creating, on a substrate and with use of molecular beam epitaxy, an epitaxial crystalline thin film doped with the rare-earth ions at a concentration of less than 100 parts per billion.
FILED Thursday, March 05, 2020
APPL NO 17/434221
CURRENT CPC
Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor
C30B 23/02 (20130101) Original (OR) Class
C30B 29/16 (20130101)
C30B 29/32 (20130101)
C30B 33/08 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 10/126 (20130101)
H01F 41/302 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136136 Parker et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) President and Fellows of Harvard College (Cambridge, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Kevin Kit Parker (Cambridge, Massachusetts);  Grant Michael Gonzalez (Somerville, Massachusetts);  Holly M. Golecki (Urbana, Illinois);  Kwanwoo Shin (Seoul, South Korea);  Josue A. Goss (Rogers, Arkansas)
ABSTRACT Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.
FILED Thursday, October 14, 2021
APPL NO 17/501005
CURRENT CPC
Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H
C08J 5/18 (20130101)
C08J 2377/10 (20130101)

Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons
D01D 5/06 (20130101)
D01D 5/18 (20130101) Original (OR) Class

Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments
D01F 6/605 (20130101)
D01F 9/00 (20130101)

Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles
D10B 2331/021 (20130101)

Technical Subjects Covered by Former US Classification
Y10T 428/249921 (20150401)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136937 Deng et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Morgan State University (Baltimore, Maryland)
ASSIGNEE(S)
INVENTOR(S) Hua Deng (Baltimore, Maryland);  Hongtao Yu (Baltimore, Maryland)
ABSTRACT Fluorescence titration of methylene blue, rhodamine B and rhodamine 6G (R6G) by silver nanoparticle (AgNP) all resulted in an initial steep quenching curve followed with a sharp turn and a much flatter quenching curve. At the turn, there are about 200,000 dye molecules per a single AgNP, signifying self-assembly of approximately 36 layers of dye molecules on the surface of the AgNP to form a micelle-like structure. These fluorescence-quenching curves fit to a mathematical model with an exponential term due to molecular self-assembly on a AgNP surface, or “self-assembly shielding effect”, and a Stern-Volmer term (nanoparticle surface enhanced quenching). Such a “super-quenching” by AgNP can only be attributed to “pre-concentration” of the dye molecules on the nanoparticle surface that yields the formation of micelle-like self-assembly, resulting in great fluorescence quenching. Overall, the fluorescence quenching titration reveals three different types of interactions of dye molecules on AgNP surface: 1) self-assembly (methylene blue, rhodamine B and R6G), 2) absorption/tight interaction (tryptamine and fluorescein), and 3) loose interaction (eosin Y). We attribute the formation of micelle-like self-assembly of these three dye molecules on AgNP to their positive charge, possession of nitrogen atoms, and with relatively large and flat aromatic moieties.
FILED Friday, August 13, 2021
APPL NO 17/401985
CURRENT CPC
Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes
C09B 62/44 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/06 (20130101)
C09K 2211/1007 (20130101)
C09K 2211/1018 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 1/30 (20130101) Original (OR) Class
G01N 2001/302 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136972 LEE et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) Rutgers, The State University of New Jersey (New Brunswick, New Jersey)
ASSIGNEE(S)
INVENTOR(S) Ki-Bum LEE (Monmouth Junction, New Jersey);  Letao YANG (Edison, New Jersey)
ABSTRACT A surface-enhanced Raman scattering (SERS) sensing system or platform and methods of using the same, where the platform comprises a graphene coated-homogeneous plasmonic metal hybrid array, which synergizes both electromagnetic mechanism (EM)- and chemical mechanism (CM)-based signal enhancement for achieving sensitive and reproducible detection of Raman signals. The system and methods of using such system or platform may be applied to the analyses of various bio/chemical molecules, such as but not limited to those found in cells, in a highly sensitive and selective manner.
FILED Wednesday, October 27, 2021
APPL NO 17/512211
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6876 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/658 (20130101) Original (OR) Class
G01N 33/54306 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136973 Rodriguez et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
NIH Office of the Director (NIHOD)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) Regents of the University of Minnesota (Minneapolis, Minnesota)
ASSIGNEE(S)
INVENTOR(S) Rebeca S. Rodriguez (St. Paul, Minnesota);  Victoria M. Szlag (St. Paul, Minnesota);  Theresa M. Reineke (Vadnais Heights, Minnesota);  Christy L. Haynes (Minneapolis, Minnesota)
ABSTRACT Methods and systems related to a linear polymer affinity agent sensor for SERS are disclosed. Use of the sensor may include mixing a linear polymer affinity agent in a sample solution, subjecting a metal substrate to the sample solution to attach the linear polymer affinity agent to the metal substrate, generating, via Raman Spectroscopy, spectral data representing the at least one linear polymer affinity agent attached to the metal substrate, and determining whether two or more analytes are present in the solution at respective minimum threshold concentrations based on the spectral data.
FILED Friday, October 29, 2021
APPL NO 17/514016
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/658 (20130101) Original (OR) Class
G01N 33/553 (20130101)
G01N 33/54373 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137017 Lazar et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
ASSIGNEE(S) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York)
INVENTOR(S) Aurel A. Lazar (New York, New York);  Tingkai Liu (Suzhou, China PRC);  Chung-Heng Yeh (Kaohsiung, Taiwan)
ABSTRACT The present disclosure provides, method, a system, and apparatus for identifying odorants. For example, the apparatus performs sensing an odorant using an olfactory sensor, encoding the sensed odorant to an electrical signal using an input processor, determining an identity representation of the odorant based on the encoded electrical signal, and determining odorant information using a time-dependent hash code based on the identity representation of the odorant.
FILED Monday, December 14, 2020
APPL NO 17/121246
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/0031 (20130101) Original (OR) Class
G01N 33/0062 (20130101)
G01N 2033/0068 (20130101)

Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/6215 (20130101)

Computational Chemistry; Chemoinformatics; Computational Materials Science
G16C 60/00 (20190201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137112 LIU et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Yilu LIU (Knoxville, Tennessee);  Wenxuan YAO (Knoxville, Tennessee);  He YIN (Knoxville, Tennessee);  Wenpeng YU (Knoxville, Tennessee)
ABSTRACT A method includes performing by a processor: determining a phase angle alignment parameter based on a ratio of a phase angle difference and a frequency difference, the phase angle difference comprising a difference between a first phase angle corresponding to a reference synchronized measurement device (SMD) and a second phase angle corresponding to a follower SMD, the frequency difference comprising a difference between a frequency at which the first and second phase angles are measured and a nominal frequency; receiving a first plurality of synchrophasor measurements of a power system signal from the reference SMD; receiving a second plurality of synchrophasor measurements of the power system signal from the follower SMD, the first plurality of synchrophasor measurements and the second plurality of synchrophasor measurements being offset in time relative to each other by a sampling time shift; and aligning phase angles of the second plurality of synchrophasor measurements with phase angles of the first plurality of synchrophasor measurements using the phase angle alignment parameter.
FILED Friday, October 30, 2020
APPL NO 17/085526
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 25/04 (20130101) Original (OR) Class
G01R 29/18 (20130101)

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 3/001 (20200101)
H02J 2203/20 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137169 ENGLUND
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Office of Advanced Cyberinfrastructure (OAC)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Dirk Robert ENGLUND (Brookline, Massachusetts)
ABSTRACT Chemical-shift nuclear magnetic resonance (NMR) spectroscopy involves measuring the effects of chemical bonds in a sample on the resonance frequencies of nuclear spins in the sample. Applying a magnetic field to the sample causes the sample nuclei to emit alternating current magnetic fields that can be detected with color centers, which can act as very sensitive magnetometers. Cryogenically cooling the sample increases the sample's polarization, which in turn enhances the NMR signal strength, making it possible to detect net nuclear spins for very small samples. Flash-heating the sample or subjecting it to a magic-angle-spinning magnetic field (instead of a static magnetic field) eliminates built-in magnetic field inhomogeneities, improving measurement sensitivity without degrading the sample polarization. Tens to hundreds of small, cryogenically cooled sample chambers can be integrated in a semiconductor substrate interlaced with waveguides that contain color centers for optically detected magnetic resonance measurements of the samples' chemical-shift NMR frequencies.
FILED Friday, September 03, 2021
APPL NO 17/465895
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/31 (20130101)
G01R 33/46 (20130101) Original (OR) Class
G01R 33/282 (20130101)
G01R 33/323 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137386 Weida et al.
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) DAYLIGHT SOLUTIONS, INC. (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) Miles James Weida (Poway, California);  Timothy Day (Poway, California)
ABSTRACT An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.
FILED Wednesday, January 19, 2022
APPL NO 17/579015
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 21/00 (20130101)
G02B 21/0056 (20130101) Original (OR) Class
G02B 21/0088 (20130101)
G02B 21/088 (20130101)
G02B 21/365 (20130101)

Pictorial Communication, e.g Television
H04N 5/33 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137397 Zou et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
APPLICANT(S) THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas)
ASSIGNEE(S) THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas)
INVENTOR(S) Jun Zou (College Station, Texas);  Song Xu (College Station, Texas)
ABSTRACT Methods are disclosed for manufacturing a Micro-ElectroMechanical Systems (MEMS) scanning mirror. In an embodiment, one method includes depositing a hinge material on a substrate and removing first and second portions of the substrate to form an outer frame, an inner frame, and a mirror plate in the substrate. First and second portions of the hinge material rotationally couple the outer frame to the inner frame and the inner frame to the mirror plate for rotation about first and second orthogonal axes of rotation. In another embodiment, a third portion of the substrate rotationally couples the inner frame to the mirror plate. In still another embodiment, an elastomer material is configured as a bending hinge that rotationally couples the outer frame to the inner frame.
FILED Thursday, March 19, 2020
APPL NO 17/438601
CURRENT CPC
Microstructural Devices or Systems, e.g Micromechanical Devices
B81B 3/0018 (20130101)
B81B 2201/042 (20130101)
B81B 2203/01 (20130101)

Optical Elements, Systems, or Apparatus
G02B 26/0833 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137484 MITTAL et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Office of Scientific Research (AFOSR)
Air Force Research Laboratory (AFRL)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Physics (PHY)
APPLICANT(S) University of Maryland, College Park (College Park, Maryland)
ASSIGNEE(S)
INVENTOR(S) Sunil MITTAL (Rockville, Maryland);  Mohammad HAFEZI (Washington, District of Columbia)
ABSTRACT Examples of the present disclosure include the use of a topological system including an array of coupled ring resonators that exhibits topological edge states to generate frequency combs and temporal dissipative Kerr solitons. The topological edge states constitute a travelling-wave super-ring resonator causing generation of at least coherent nested optical frequency combs, and self-formation of nested temporal solitons that are robust against defects in the array at a mode efficiency exceeding 50%.
FILED Monday, November 01, 2021
APPL NO 17/515757
CURRENT CPC
Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/3513 (20130101) Original (OR) Class
G02F 1/3536 (20130101)
G02F 2203/15 (20130101)
G02F 2203/17 (20130101)
G02F 2203/54 (20130101)
G02F 2203/56 (20130101)

Transmission
H04B 10/506 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137808 Krishnamurthy et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)
INVENTOR(S) Vinayak Raman Krishnamurthy (West Lafayette, Indiana);  Cecil Piya (West Lafayette, Indiana);  Karthik Ramani (West Lafayette, Indiana)
ABSTRACT Some examples provides a set of frameworks, process and methods aimed at enabling the expression and exploration of free-form and parametric 3D shape designs enabled through natural interactions with a hand-held mobile device acting as a controller for 3D virtual objects. A reference plane in a virtual space generated by the location of the mobile device may be used to select a 3D virtual object intersected by the reference plane. Positioning of the mobile device may also be used to control a pointer in the virtual space. In an example, the orientation of the mobile device may be detected by an accelerometer or gyroscope. In example, the position of the mobile device may be detected by a position sensor.
FILED Monday, January 10, 2022
APPL NO 17/571651
CURRENT CPC
Electric Digital Data Processing
G06F 3/017 (20130101)
G06F 3/0346 (20130101)
G06F 3/04845 (20130101)
G06F 3/04883 (20130101) Original (OR) Class

Image Data Processing or Generation, in General
G06T 19/006 (20130101)
G06T 19/20 (20130101)
G06T 2219/2016 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138368 Gentry et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Russell Gentry (Atlanta, Georgia);  Benjamin Tasistro-Hart (Atlanta, Georgia)
ABSTRACT An exemplary embodiment provides a method of predicting a geometry of a turbine blade, comprising: obtaining a point cloud of the turbine blade, the point cloud comprising a plurality of points corresponding to locations on an external contour of the turbine blade; generating an external mesh for the turbine blade based on point cloud; defining a reference axis along the length of the blade; generating a plurality of sampling planes along the length of the reference axis, each sampling plane being normal to the reference axis and having a shape defined by portions of the mesh intersecting the sampling plane; for each of the plurality of sampling planes, matching the sampling plane to an airfoil profile in a database of known airfoil profiles; and creating a geometrical representation of the turbine blade by placing the airfoils on the reference axis and connecting the perimeter of each of the airfoils.
FILED Friday, February 28, 2020
APPL NO 17/434588
CURRENT CPC
Electric Digital Data Processing
G06F 30/17 (20200101) Original (OR) Class
G06F 30/20 (20200101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/30 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138608 Ramette et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Physics (PHY)
APPLICANT(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
ASSIGNEE(S) Massachusetts Institute of Technology (Cambridge, Massachusetts)
INVENTOR(S) Joshua Ramette (Cambridge, Massachusetts);  Josiah Sinclair (Cambridge, Massachusetts);  Vladan VULETIC (Cambridge, Massachusetts)
ABSTRACT An all-to-all coupled, high-fidelity, error-correctable quantum computer can scale to hundreds of qubits within a single cavity of moderate cooperativity with existing neutral atom technology. This quantum processor can enact teleported gates among any pair of qubits using a local Rydberg interaction between each qubit and a separate network of atoms that distribute entanglement via a cavity mode. Small atomic ensembles at network nodes allow for ultrafast, nondestructive readout with high fidelity by substantially shifting the resonance of even a poor-quality cavity. Fast readout enables near-deterministic entanglement distribution among network atoms despite cavity losses as well as syndrome measurements of qubit atoms for error correction.
FILED Monday, August 30, 2021
APPL NO 17/460385
CURRENT CPC
Electric Digital Data Processing
G06F 9/30101 (20130101)

Computer Systems Based on Specific Computational Models
G06N 10/00 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138630 Bagchi et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Saurabh Bagchi (West Lafayette, Indiana);  Nawanol Theera-Ampornpunt (West Lafayette, Indiana)
ABSTRACT System and methods for predictive application streaming are provided. The system may execute an application and, concurrently, the system may while load data blocks not stored on the device using a construct of superblocks. The system may detect an access event caused by an application accessing a data block in a memory. The system may determine, in response to the access event, a superblock comprising a plurality of blocks that are historically accessed within the same execution time window as the block. The system may forecast, based on the superblock and a machine learning model, superblocks to be accessed by the application that are not stored in the memory. The system may download the superblocks from a remote endpoint accessible via a network.
FILED Monday, November 01, 2021
APPL NO 17/516497
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 5/02 (20130101)
G06N 20/00 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138631 Jaskie et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
Office of International Science and Engineering (OISE)
APPLICANT(S) Kristen Jaskie (Scottsdale, Arizona);  Joshua Martin (Geneva, Illinois);  Andreas Spanias (Tempe, Arizona)
ASSIGNEE(S) Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona)
INVENTOR(S) Kristen Jaskie (Scottsdale, Arizona);  Joshua Martin (Geneva, Illinois);  Andreas Spanias (Tempe, Arizona)
ABSTRACT Various embodiments of a system and associated method for identifying and classifying faults in a photovoltaic array using relatively little labeled data are described herein. In particular, the system builds on existing PU classification techniques by addition of a feedback loop that enables classification of limited operational data of a photovoltaic array by expanding a plurality of features within the operational data based on a learned importance of each feature.
FILED Tuesday, November 02, 2021
APPL NO 17/517447
CURRENT CPC
Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220139254 Ramani et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Education and Human Resources (EHR)
Division of Undergraduate Education (DUE)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S)
INVENTOR(S) Karthik Ramani (West Lafayette, Indiana);  Gaoping Huang (West Lafayette, Indiana);  Alexander J. Quinn (West Lafayette, Indiana);  Yuanzhi Cao (Redmond, Washington);  Tianyi Wang (West Lafayette, Indiana);  Xun Qian (West Lafayette, Indiana)
ABSTRACT A machine task tutorial system is disclosed that utilizes augmented reality to enable an expert user to record a tutorial for a machine task that can be learned by different trainee users in an adaptive manner. The machine task tutorial system advantageously utilizes an adaptation model that focuses on spatial and bodily visual presence for machine task tutoring. The machine task tutorial system advantageously enables adaptive tutoring in the recorded-tutorial environment based on machine state and user activity recognition. The machine task tutorial system advantageously utilizes AR to provide tutorial recording, adaptive visualization, and state recognition. In this way, the machine task tutorial system supports more effective apprenticeship and training for machine tasks in workshops or factories.
FILED Wednesday, November 03, 2021
APPL NO 17/517949
CURRENT CPC
Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers
G06K 9/00342 (20130101)
G06K 9/3233 (20130101)

Computer Systems Based on Specific Computational Models
G06N 20/00 (20190101)

Image Data Processing or Generation, in General
G06T 13/40 (20130101)
G06T 19/006 (20130101)
G06T 2210/36 (20130101)

Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams
G09B 5/02 (20130101)
G09B 19/24 (20130101)
G09B 19/0069 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220139639 Thomas et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) University of Central Florida Research Foundation, Inc. (Orlando, Florida)
ASSIGNEE(S) University of Central Florida Research Foundation, Inc. (Orlando, Florida)
INVENTOR(S) Jayan Thomas (Orlando, Florida);  Deepak Pandey (Orlando, Florida);  Kowsik Sambath Kumar (Orlando, Florida)
ABSTRACT Energized composites include vertically aligned graphene on carbon fibers (VGCF). The VGCF enhances surface area available for charge storage, acts as templates for depositing other charge storing materials and provides stability for a minimum of 100,000 discharge cycles. The final storage device is in the order of high strength carbon fiber matrix with active material, glass fiber separator with polymer electrolyte and another carbon fiber matrix with active material. To achieve higher voltage or current, devices can be connected in series or parallel, respectively. The whole structure is made into a structural component by infusing epoxy resin. An alternating pattern of energy storage devices allows for the epoxy resin to seep through the whole structure and strongly bind them to make a monolith multifunctional composite. The high strength energized composites can power any electrical devices including electric vehicles, portable electronics, and space vehicles without any tradeoff between energy and structural integrity.
FILED Thursday, November 04, 2021
APPL NO 17/518985
CURRENT CPC
Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles
B60L 50/40 (20190201)

Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type
H01G 11/40 (20130101) Original (OR) Class
H01G 11/44 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140463 Schuster et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
Combat Capabilities Development Command (CCDC)
Army Research Laboratory (CCDC ARL)
Army Research Office (CCDC ARO)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Materials Research (DMR)
APPLICANT(S) THE UNIVERSITY OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) David Schuster (Chicago, Illinois);  Aziza Suleymanzade (Cambridge, Massachusetts);  Jonathan Simon (Chicago, Illinois);  Alexander Anferov (Chicago, Illinois)
ABSTRACT A millimeter-wave resonator is produced by drilling a plurality of holes into a piece of metal. Each hole forms an evanescent tube having a lowest cutoff frequency. The holes spatially intersect to form a seamless three-dimensional cavity whose fundamental cavity mode has a resonant frequency that is less than the cutoff frequencies of all the evanescent tubes. Below cutoff, the fundamental cavity mode does not couple to the waveguide modes, and therefore has a high internal Q. Millimeter waves can be coupled into any of the tubes to excite an evanescent mode that couples to the fundamental cavity mode. The tubes also provide spatial and optical access for transporting atoms into the cavity, where they can be trapped while spatially overlapping the fundamental cavity mode. The piece of metal may be superconducting, allowing the resonator to be used in a cryogenic environment for quantum computing and information processing.
FILED Thursday, October 28, 2021
APPL NO 17/452654
CURRENT CPC
Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type
H01P 7/04 (20130101) Original (OR) Class
H01P 11/008 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140607 LIU et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Yilu LIU (Knoxville, Tennessee);  Kaiqi SUN (Knoxville, Tennessee);  Huangqing XIAO (Knoxville, Tennessee)
ABSTRACT A high voltage direct current (HVDC) transmission system comprises a first terminal comprising a first voltage source converter (VSC) having a first and second VSC terminals and a first line commutated converter (LCC) having first and second LCC terminals; a second terminal comprising a second VSC having third and fourth VSC terminals and a second LCC having third and fourth LCC terminals; and a transmission line pair comprising a positive transmission line that couples the first VSC terminal and the first LCC terminal of the first VSC and the first LCC, respectively, to the third VSC terminal and the third LCC terminal of the second VSC and the second LCC, respectively, and a second positive line that couples the second VSC terminal and the second LCC terminal of the first VSC and the first LCC, respectively, to the fourth VSC terminal and the fourth LCC terminal of the second VSC and the second LCC, respectively.
FILED Friday, October 30, 2020
APPL NO 17/085595
CURRENT CPC
Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 3/36 (20130101) Original (OR) Class

Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof
H02M 7/219 (20130101)
H02M 7/521 (20130101)
H02M 7/1626 (20130101)
H02M 7/53871 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140648 ALTARJAMI et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Engineering Education and Centers (EEC)
APPLICANT(S) University of Tennessee Research Foundation (Knoxville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Ibrahim Abdullah S. ALTARJAMI (Knoxville, Tennessee);  Evangelos FARANTATOS (Encino, California);  Hossein HOOSHYAR (White Plains, New York);  Yilu LIU (Knoxville, Tennessee);  Mahendra PATEL (Phoenixville, Pennsylvania);  Huangqing XIAO (Knoxville, Tennessee);  Chengwen ZHANG (Knoxville, Tennessee);  Yi ZHAO (Knoxville, Tennessee);  Lin ZHU (Knoxville, Tennessee)
ABSTRACT A method includes injecting a probe signal into a power system; receiving a measurement of an operational parameter of the power system responsive to injecting the probe signal into the power system; generating a transfer function model of the power system based on the measurement of the operational parameter of the power system and the probe signal; and updating at least one control parameter of a Wide Area Damping Controller (WADC) communicatively coupled to the power system based on the transfer function model.
FILED Friday, October 30, 2020
APPL NO 17/085703
CURRENT CPC
Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 13/0001 (20200101)
H02J 13/00016 (20200101)
H02J 13/00026 (20200101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220141077 PROTHERO et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Industrial Innovation and Partnerships (IIP)
Directorate of Technology
Translational Impacts (TI)
APPLICANT(S) Astrapi Corporation (Dallas, Texas)
ASSIGNEE(S) Astrapi Corporation (Dallas, Texas)
INVENTOR(S) Jerrold PROTHERO (Delray Beach, Florida);  James J. STERLING (Chambersburg, Pennsylvania)
ABSTRACT Systems, devices, and methods of the present invention enhance data transmission through the use of polynomial symbol waveforms (PSW) and sets of PSWs corresponding to a symbol alphabet is here termed a PSW alphabet. Methods introduced here are based on modifying polynomial alphabet by changing the polynomial coefficients or roots of PSWs and/or shaping of the polynomial alphabet, such as by polynomial convolution, to produce a designed PSW alphabet including waveforms with improved characteristics for data transmission.
FILED Monday, January 17, 2022
APPL NO 17/577082
CURRENT CPC
Transmission of Digital Information, e.g Telegraphic Communication
H04L 27/363 (20130101)
H04L 27/2639 (20130101)
H04L 27/2647 (20130101)
H04L 27/3405 (20130101) Original (OR) Class
H04L 27/3494 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220141588 LiKamWa et al.
FUNDED BY
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Robert LiKamWa (Tempe, Arizona);  Frank Wencheng Liu (Tempe, Arizona)
ASSIGNEE(S)
INVENTOR(S) Robert LiKamWa (Tempe, Arizona);  Frank Wencheng Liu (Tempe, Arizona)
ABSTRACT A system to output a cross-talk cancelled spatial audio signal to two speakers, including a user tracking module to provide a location and orientation of a head of a user, and a time-domain dynamic crosstalk cancellation module to receive a spatial audio signal, the location and orientation of the head of the user from the user tracking module, a location for each of the two speakers, and generate the time-domain crosstalk cancelled spatial audio signal based thereon.
FILED Tuesday, February 25, 2020
APPL NO 17/433797
CURRENT CPC
Electric Digital Data Processing
G06F 3/165 (20130101)

Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems
H04R 3/14 (20130101) Original (OR) Class
H04R 5/02 (20130101)
H04R 5/04 (20130101)

Stereophonic Systems
H04S 1/007 (20130101)
H04S 7/303 (20130101)
H04S 2400/11 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220141821 D'ORO et al.
FUNDED BY
Department of Defense (DOD)
Department of the Navy (DON)
Office of Naval Research (ONR)
National Science Foundation (NSF)
Directorate for Computer and Information Science and Engineering (CISE)
Division of Computer and Network Systems (CNS)
APPLICANT(S) Northeastern University (Boston, Massachusetts)
ASSIGNEE(S)
INVENTOR(S) Salvatore D'ORO (Allston, Massachusetts);  Francesco RESTUCCIA (Boston, Massachusetts);  Tommaso MELODIA (Newton, Massachusetts)
ABSTRACT Methods and systems for allocating radio access network (RAN) spectrum resources among a plurality of mobile virtual network operators (MVNOs) of a network of base stations. The methods and systems include determining a slicing enforcement policy that assigns resource blocks (RBs) of frequency units and time slots of spectrum resources to each MVNO according to a slicing policy in which each MVNO is allocated an amount of the spectrum resources on at least one base station in a determined time span. The slicing enforcement policy minimizes overlap between each MVNO's set of RBs with another MVNO's set of RBs on a same base station, and interference between each MVNO's set of RBs with another MVNO's set of RBs on an interfering base station.
FILED Friday, January 24, 2020
APPL NO 17/424522
CURRENT CPC
Wireless Communication Networks
H04W 16/10 (20130101)
H04W 16/14 (20130101)
H04W 48/18 (20130101)
H04W 72/0453 (20130101) Original (OR) Class
H04W 84/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Energy (DOE) 

US 20220132843 Whitten et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
APPLICANT(S) David G. Whitten (Albuquerque, New Mexico);  Dylan Brown (Albuquerque, New Mexico);  Jianzhong Yang (Albuquerque, New Mexico);  Edward Strach (Albuquerque, New Mexico);  Mohammed Khalil (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) David G. Whitten (Albuquerque, New Mexico);  Dylan Brown (Albuquerque, New Mexico);  Jianzhong Yang (Albuquerque, New Mexico);  Edward Strach (Albuquerque, New Mexico);  Mohammed Khalil (Albuquerque, New Mexico)
ABSTRACT The present disclosure provides an antimicrobial substrate including a substrate and a polythiophene polymer. The polythiophene polymer has a number of repeated monomer units from n is 5-14 or 30 to 120, a number average molecular weight (Mn) from 1,000 to 4,000 or 10,000 to 40,000; and a polydispersity index (PDI) from 1 to 1.3. The present disclosure also provides the polythiophene polymer and uses thereof.
FILED Thursday, September 23, 2021
APPL NO 17/448635
CURRENT CPC
Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators
A01N 25/34 (20130101)
A01N 43/10 (20130101) Original (OR) Class
A01N 43/50 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 2/18 (20130101)
A61L 2300/404 (20130101)

Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds
C08G 61/126 (20130101)
C08G 2261/143 (20130101)
C08G 2261/149 (20130101)
C08G 2261/224 (20130101)
C08G 2261/3223 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220134291 Bhave et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-Battelle, LLC (Oak Ridge, Tennessee);  All American Lithium LLC (Brawley, California)
ASSIGNEE(S) UT-Battelle, LLC (Oak Ridge, Tennessee);  All American Lithium LLC (Brawley, California)
INVENTOR(S) Ramesh R. Bhave (Knoxville, Tennessee);  Stephen Harrison (Benicia, California);  Bruce A. Moyer (Oak Ridge, Tennessee);  M. Parans Paranthaman (Knoxville, Tennessee)
ABSTRACT A lithium extraction composite comprising: (i) a porous support and (ii) particles of a lithium-selective sorbent material coated on at least one surface of the support, wherein the support has a planar membrane, fiber (or rod), or tubular shape. A method for extracting and recovering a lithium salt from an aqueous solution by use of the above-described composition is also described, the method comprising (a) flowing the aqueous source solution through a first zone or over a first surface of the lithium extraction composite to result in selective lithium intercalation in the lithium-selective sorbent material in the first zone or first surface; and (b) simultaneously recovering lithium salt extracted in step (a) from said lithium-selective sorbent material by flowing an aqueous stripping solution through a second zone or over a second surface of the lithium extraction composite in which lithium ions from the first zone or first surface diffuse.
FILED Tuesday, January 11, 2022
APPL NO 17/572773
CURRENT CPC
Separation
B01D 69/04 (20130101)
B01D 69/08 (20130101)
B01D 69/10 (20130101)
B01D 69/12 (20130101) Original (OR) Class
B01D 71/021 (20130101)
B01D 71/024 (20130101)
B01D 71/34 (20130101)
B01D 2257/204 (20130101)

Production and Refining of Metals; Pretreatment of Raw Materials
C22B 26/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220134316 Chou et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Sandia National Laboratories (SNL)
Federally Funded Research and Development Center (FFRDC)
Operated by National Technology and Engineering Solutions of Sandia, LLC (NTESS) at Albuquerque, NM
APPLICANT(S) National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico);  STC.UNM (Albuquerque, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Stanley Shihyao Chou (Albuquerque, New Mexico);  Christopher Ryan Riley (Albuquerque, New Mexico);  Abhaya Datye (Albuquerque, New Mexico);  Andrew de la Riva (Albuquerque, New Mexico)
ABSTRACT High surface area, high entropy oxides comprising multiple metal cations in a single-phase fluorite lattice material enables intrinsic catalytic activity without platinum group metals, tunable oxygen storage capacity, and thermal stability. These properties can be obtained through a facile sol-gel synthesis to provide a low-temperature route for production of phase-pure multi-cationic oxides. The resulting materials achieved significantly higher surface area and catalytic performance, taking advantage of all the properties endowed by the various cations in the composition.
FILED Tuesday, November 03, 2020
APPL NO 17/087938
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 23/10 (20130101)
B01J 23/34 (20130101)
B01J 23/83 (20130101) Original (OR) Class
B01J 35/1009 (20130101)
B01J 37/04 (20130101)
B01J 37/0018 (20130101)
B01J 37/036 (20130101)
B01J 37/088 (20130101)
B01J 37/0236 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 32/50 (20170801)

Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals
C01F 17/241 (20200101)

Compounds Containing Metals Not Covered by Subclasses C01D or C01F
C01G 45/1228 (20130101)
C01G 49/0054 (20130101)

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/30 (20130101)
C01P 2002/50 (20130101)
C01P 2006/12 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220134435 Scime et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT Battelle, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Luke R. Scime (Knoxville, Tennessee);  Vincent C. Paquit (Knoxville, Tennessee);  Desarae J. Goldsby (Knoxville, Tennessee);  William H. Halsey (Knoxville, Tennessee);  Chase B. Joslin (Knoxville, Tennessee);  Michael D. Richardson (Knoxville, Tennessee);  Derek C. Rose (Knoxville, Tennessee);  Derek H. Siddel (Knoxville, Tennessee)
ABSTRACT Detection and classification of anomalies for powder bed metal additive manufacturing. Anomalies, such as recoater blade impacts, binder deposition issues, spatter generation, and some porosities, are surface-visible at each layer of the building process. A multi-scaled parallel dynamic segmentation convolutional neural network architecture provides additive manufacturing machine and imaging system agnostic pixel-wise semantic segmentation of layer-wise powder bed image data. Learned knowledge is easily transferrable between different additive manufacturing machines. The anomaly detection can be conducted in real-time and provides accurate and generalizable results.
FILED Tuesday, November 17, 2020
APPL NO 16/950484
CURRENT CPC
Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder
B22F 10/80 (20210101) Original (OR) Class

Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/153 (20170801)
B29C 64/386 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 10/00 (20141201)

Image Data Processing or Generation, in General
G06T 3/4046 (20130101)
G06T 3/4053 (20130101)
G06T 7/0004 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135409 Schenkel et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S) The Regents of The University of California (Oakland, California)
ASSIGNEE(S)
INVENTOR(S) Thomas Schenkel (San Francisco, California);  Arun Persaud (El Cerrito, California);  Edward Barnard (Berkeley, California)
ABSTRACT This disclosure provides systems, methods, and apparatus related to color centers. In one aspect, a method includes providing diamond doped with a dopant. A heavy-ion is directed to the diamond that passes through the diamond. The heavy-ion forms a line of dopant-vacancy centers as it passes through the diamond.
FILED Monday, October 25, 2021
APPL NO 17/509241
CURRENT CPC
Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures
B82Y 20/00 (20130101)

Non-metallic Elements; Compounds Thereof;
C01B 32/28 (20170801) Original (OR) Class

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/52 (20130101)
C01P 2004/16 (20130101)

Materials for Miscellaneous Applications, Not Provided for Elsewhere
C09K 11/65 (20130101)

Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor
C30B 29/04 (20130101)
C30B 33/04 (20130101)

Optical Elements, Systems, or Apparatus
G02B 1/002 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135443 Lin
FUNDED BY
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S) West Virginia University Board of Governors on behalf of West Virginia University (Morgantown, West Virginia)
ASSIGNEE(S)
INVENTOR(S) Lian-Shin Lin (Morgantown, West Virginia)
ABSTRACT This invention provides processes for treating a mixture of produced water and blowdown water comprising introducing produced water (PW) into blowdown water (BD) for forming a PW-BD water mixture, softening the PW-BD water mixture, subjecting the PW-BD water mixture to activated carbon filtration and reverse osmosis membrane desalination. The process generates a product water and a brine by-product.
FILED Friday, September 17, 2021
APPL NO 17/448004
CURRENT CPC
Treatment of Water, Waste Water, Sewage, or Sludge
C02F 1/001 (20130101)
C02F 1/441 (20130101) Original (OR) Class
C02F 1/4618 (20130101)
C02F 5/02 (20130101)
C02F 9/00 (20130101)
C02F 2101/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135507 Moore et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Los Alamos National Laboratory (LANL)
Federally Funded Research and Development Center (FFRDC)
Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S) U.S. Department of Energy (Washington, District of Columbia)
ASSIGNEE(S) U.S. Department of Energy (Washington, District of Columbia)
INVENTOR(S) Cameron Moore (Los Alamos, New Mexico);  Trideep Rajale (Los Alamos, New Mexico);  Karthikeyan K. Ramasamy (Richland, Washington);  Andrew Sutton (Los Alamos, New Mexico)
ABSTRACT The invention relates to a two-way approach to isolate, recover and upgrade 2,3-Butanediol (2,3-BDO) from fermentation broth. A complete separation and recovery process for 2,3-BDO using acetalization and trans-acetalization sequence. Acetalization with butyraldehyde using heterogeneous catalysts, either Amberlyst-15® or Nafion NR50®, efficiently isolates 2,3-BDO as phase-separated protected dioxolane. The approach provides significant process advantages with easy product recovery and high recyclability of the catalyst. Trans-acetalization of dioxolane with methanol (methanolysis) followed by distillation of acetal, yielded very high purity 2,3-BDO with about 90% isolated yield. Alternatively, dioxolane is used in a process direct to methyl ethyl ketone (MEK) as a BDO synthon allowing for recovery of the aldehyde.
FILED Tuesday, November 03, 2020
APPL NO 17/087841
CURRENT CPC
Acyclic or Carbocyclic Compounds
C07C 29/92 (20130101) Original (OR) Class
C07C 2521/12 (20130101)
C07C 2531/025 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135623 Williams et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Los Alamos National Laboratory (LANL)
Federally Funded Research and Development Center (FFRDC)
Operated by Triad National Security, LLC (TRIAD) at Los Alamos, NM
APPLICANT(S) TRIAD National Security, LLC. (Los Alamos, New Mexico)
ASSIGNEE(S)
INVENTOR(S) Robert F. Williams (Los Alamos, New Mexico);  David Owen Baumann (Los Alamos, New Mexico);  John Cameron Gordon (Los Alamos, New Mexico)
ABSTRACT The present disclosure provides peptoid-based chelating ligands, corresponding cyclic peptoids, and methods of making thereof. Functional groups may be tailored for high metal binding affinity and selectivity. The side chains of a cyclic peptoid according to the present disclosure may be selected based on, for example, high affinity for actinide or other metal ions, selectivity for actinide or other metal ions, the ability to recover a metal once it is bound to the peptoid, and whether the overall peptoid should be hydrophobic or hydrophilic. Unlike siderophores, peptoid-based chelating ligands of the present disclosure are not readily hydrolyzed under physiological conditions. Therefore, peptoid-based chelating ligands may be, for example, used to treat actinide (e.g., iron and lead) poisoning in vivo. Moreover, peptoid-based chelating ligands of the present disclosure may be used for medical imaging, chelation therapy, drug delivery, and separation technologies, for example.
FILED Friday, January 14, 2022
APPL NO 17/576577
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 47/64 (20170801)
A61K 49/0056 (20130101)

Peptides
C07K 7/54 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135892 PATEL
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Corps of Engineers (USACE)
Construction Engineering Research Laboratory (CERL)
Department of Energy (DOE)
Office of Fossil Energy and Carbon Management (FECM)
APPLICANT(S) Nikhil Manubhai PATEL (Grand Forks, North Dakota)
ASSIGNEE(S)
INVENTOR(S) Nikhil Manubhai PATEL (Grand Forks, North Dakota)
ABSTRACT The present invention discloses a gasifier and/or a gasification process that provides a long, uniform temperature zone in the gasifier, regardless of the particle size, chemical composition, and moisture content of the fuel by sandwiching a reduction zones between two oxidation zones. The gasifier and/or gasification process has a char that is more energy-dense and almost devoid of moisture that affords for an additional (or char) oxidation zone with a temperature that is higher than a first oxidation zone which is closer to an evaporation and devolatilization zone. As such, the additional (or char) oxidation zone contributes to augmenting the reduction zone temperature, thereby providing a favorable dual impact in improving syngas composition and near-complete conversion of the tar.
FILED Friday, January 07, 2022
APPL NO 17/570448
CURRENT CPC
Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases
C10J 3/08 (20130101) Original (OR) Class
C10J 3/22 (20130101)
C10J 3/26 (20130101)
C10J 3/723 (20130101)
C10J 2300/092 (20130101)
C10J 2300/093 (20130101)
C10J 2300/0946 (20130101)
C10J 2300/0956 (20130101)
C10J 2300/0959 (20130101)
C10J 2300/0976 (20130101)
C10J 2300/1246 (20130101)

Purifying or Modifying the Chemical Composition of Combustible Gases Containing Carbon Monoxide
C10K 1/024 (20130101)
C10K 1/026 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136016 TRINH et al.
FUNDED BY
Department of Energy (DOE)
APPLICANT(S) UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee)
ASSIGNEE(S) UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee)
INVENTOR(S) Cong T. TRINH (Knoxville, Tennessee);  Hyeongmin SEO (Elkton, Maryland);  Jong-Won LEE (Knoxville, Tennessee)
ABSTRACT A modified chloramphenicol acetyltransferase comprising a tyrosine residue 20 having a phenylalanine (Y20F) mutation, a microorganism harboring the modified chloramphenicol acetyltransferase, and a method of producing ester by feeding the microorganism are disclosed. The method includes providing the microorganism harboring a modified chloramphenicol acetyltransferase in an environment suitable for the microorganism to produce an ester and feeding the microorganism (i) a sugar or a cellulose, and (ii) an alcohol and/or a carboxylic acid.
FILED Tuesday, November 02, 2021
APPL NO 17/453306
CURRENT CPC
Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media
C12N 9/1033 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 7/62 (20130101) Original (OR) Class

Enzymes
C12Y 203/01028 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136119 Flanders et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
Department of Energy (DOE)
Office of Science (DOE-SC)
National Science Foundation (NSF)
Directorate of Technology
Translational Impacts (TI)
APPLICANT(S) Opus 12 Incorporated (Berkeley, California)
ASSIGNEE(S)
INVENTOR(S) Nicholas H. Flanders (San Francisco, California);  Kendra P. Kuhl (Oakland, California);  Etosha R. Cave (Berkeley, California);  Sichao Ma (Dublin, California);  Ziyang Huo (Moraga, California);  Carter S. Haines (Berkeley, California);  Timothy A. Bekkedahl (Sunnyvale, California);  Kathryn L. Corp (Berkeley, California);  Ashley D. Mishra (Danville, California);  Edward Izett (Berkeley, California)
ABSTRACT A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition.
FILED Tuesday, August 03, 2021
APPL NO 17/444356
CURRENT CPC
Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus
B01J 20/08 (20130101)
B01J 20/10 (20130101)
B01J 20/20 (20130101)
B01J 20/3483 (20130101)
B01J 2220/42 (20130101)

Apparatus for Enzymology or Microbiology;
C12M 43/00 (20130101)

Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture
C12P 5/023 (20130101)
C12P 7/06 (20130101)
C12P 7/16 (20130101)
C12P 7/52 (20130101)
C12P 7/54 (20130101)

Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor
C25B 3/03 (20210101)
C25B 3/26 (20210101)
C25B 13/08 (20130101)
C25B 15/081 (20210101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136133 SINGH et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Argonne National Laboratory (ANL)
Federally Funded Research and Development Center (FFRDC)
Operated by UChicago Argonne, LLC (UCHICAGO) at Argonne, IL
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California (UC BERKELEY) at Berkeley, CA
National Science Foundation (NSF)
Directorate for Engineering (ENG)
Division of Electrical, Communications and Cyber Systems (ECCS)
APPLICANT(S) THE UNIVERSITY OF CHICAGO (Chicago, Illinois)
ASSIGNEE(S)
INVENTOR(S) Manish SINGH (Chicago, Illinois);  Tian ZHONG (Chicago, Illinois);  Supratik GUHA (Chicago, Illinois)
ABSTRACT The present disclosure includes a thin film assembly comprising a substrate and an epitaxial crystalline thin film disposed on the substrate, wherein the epitaxial crystalline thin film is a single crystal, wherein at least a portion of the epitaxial crystalline thin film is doped with rare-earth ions at a concentration of less than 100 parts per billion. The disclosure further includes a method of manufacturing a thin film assembly, the method comprising creating, on a substrate and with use of molecular beam epitaxy, an epitaxial crystalline thin film doped with the rare-earth ions at a concentration of less than 100 parts per billion.
FILED Thursday, March 05, 2020
APPL NO 17/434221
CURRENT CPC
Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor
C30B 23/02 (20130101) Original (OR) Class
C30B 29/16 (20130101)
C30B 29/32 (20130101)
C30B 33/08 (20130101)

Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties
H01F 10/126 (20130101)
H01F 41/302 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136735 RENDALL et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Oak Ridge National Laboratory (ORNL)
Federally Funded Research and Development Center (FFRDC)
Operated by UT-Battelle, LLC (UTB) at Oak Ridge, TN
APPLICANT(S) UT-BATTELLE, LLC (Oak Ridge, Tennessee)
ASSIGNEE(S)
INVENTOR(S) JOSEPH D. RENDALL (Oak Ridge, Tennessee);  KYLE R. GLUESENKAMP (Knoxville, Tennessee);  ANTHONY C. GEHL (Knoxville, Tennessee);  JERALD A. ATCHLEY (Oak Ridge, Tennessee)
ABSTRACT A diffuser for a water heater fill tubes having a tube wall with an outside diameter. The diffuser includes an elongated flexible diffuser body for positioning at the outlet end of the fill tube. The diffuser body has a sealing end for sealing with an outside surface of the fill tube wall closest to the inlet end of the fill tube, and an open end for positioning at an end closest to the outlet end of the fill tube. The open end has a diameter larger than an outside diameter of the tube wall, thereby creating an diffuser water outlet opening between the diffuser body and the tube wall for redirecting radial water flow emanating from the fill tube water outlet opening(s) toward the diffuser outlet opening. A fill tube assembly for a water heater, a water heater, and a method for heating water are also disclosed.
FILED Friday, March 05, 2021
APPL NO 17/193344
CURRENT CPC
Fluid Heaters, e.g Water or Air Heaters, Having Heat Generating Means, in General
F24H 1/186 (20130101)
F24H 9/0015 (20130101) Original (OR) Class
F24H 9/124 (20130101)
F24H 9/2035 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136943 Busenitz et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Kansas City National Security Campus (KCNSC)
NNSA Critical Mission Site
Operated by Honeywell Federal Manufacturing & Technologies, LLC (FM&T) at Kansas City, MO
APPLICANT(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
ASSIGNEE(S) Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri)
INVENTOR(S) Clark Busenitz (Overland Park, Kansas);  Weston A. McGuire (Overland Park, Kansas)
ABSTRACT An assembly for shock testing a specimen, the assembly including first and second opposing brackets and opposing lower and upper caps. The opposing brackets include lower and upper angled surfaces. The lower cap includes lower angled surfaces configured to engage the lower angled surfaces of the left and right brackets. The upper cap includes upper angled surfaces configured to engage the upper angled surfaces of the left and right brackets. The first and second brackets are configured to be drawn toward each other via fasteners, thereby wedging the lower and upper caps toward each other against the specimen.
FILED Monday, January 10, 2022
APPL NO 17/571583
CURRENT CPC
Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for
G01M 7/08 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 3/04 (20130101) Original (OR) Class
G01N 3/30 (20130101)
G01N 2203/026 (20130101)
G01N 2203/0256 (20130101)
G01N 2203/0405 (20130101)
G01N 2203/0482 (20130101)
G01N 2203/0676 (20130101)

Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement
G01P 15/18 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136999 Garimella et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Pacific Northwest National Laboratory (PNNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Memorial Institute (BMI) at Richland, WA
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Venkata BS Garimella (Richland, Washington);  Ahmed M. Hamid (Richland, Washington);  Yehia M. Ibrahim (West Richland, Washington);  Richard D. Smith (Richland, None)
ABSTRACT Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation.
FILED Tuesday, December 21, 2021
APPL NO 17/557690
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 27/624 (20130101) Original (OR) Class

Electric Discharge Tubes or Discharge Lamps
H01J 49/26 (20130101)
H01J 49/0027 (20130101)
H01J 49/062 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137452 DUOSS et al.
FUNDED BY
Department of Energy (DOE)
National Nuclear Security Administration (NNSA)
Lawrence Livermore National Laboratory (LLNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Lawrence Livermore National Security LLC (LLNS) at Livermore, CA
APPLICANT(S) Lawrence Livermore National Security, LLC (Livermore, California);  Board of Regents, The University of Texas System (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Eric B. DUOSS (Danville, California);  James OAKDALE (Castro Valley, California);  Nicholas Anthony RODRIGUEZ (Austin, Texas);  Hongtao SONG (Austin, Texas);  Richard CRAWFORD (Austin, Texas);  Carolyn SEEPERSAD (Austin, Texas);  Morgan CHEN (Richardson, Texas)
ABSTRACT The present disclosure relates to a liquid crystal display (LCD) system. The system in one example has a light source for generating unpolarized light, and an LCD screen arranged in a path of transmittance of the unpolarized light. First and second wire grid polarizers are arranged adjacent to the LCD screen and each have a plurality of nano-scale wires, with the first and second wire grid polarizers have differing polarizations. A pitch of each of the nano-scale wires is no larger than one-third a wavelength of the unpolarized light from the light source. The wire grid polarizers create, in connection with operation of the LCD screen, a 2D light mask suitable for initiating the polymerization of an optically curable material.
FILED Friday, October 30, 2020
APPL NO 17/085244
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/286 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 30/00 (20141201)

Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters
G02F 1/133512 (20130101)
G02F 1/133528 (20130101) Original (OR) Class
G02F 1/133603 (20130101)
G02F 2001/133531 (20130101)
G02F 2001/133548 (20130101)
G02F 2202/36 (20130101)

Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor;
G03F 7/20 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138611 Siddiqi et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Lawrence Berkeley National Laboratory (LBNL)
Federally Funded Research and Development Center (FFRDC)
Operated by University of California (UC BERKELEY) at Berkeley, CA
APPLICANT(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
ASSIGNEE(S) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California)
INVENTOR(S) Irfan Siddiqi (Berkeley, California);  Jie Luo (Berkeley, California);  Brian Marinelli (Berkeley, California)
ABSTRACT A superconducting quantum processor unit for quantum computing is provided. The processor unit is formed from the union of a qubit chip and a wiring chip with superconducting bonding bumps and spacers. The bumps may be densely distributed around active elements between the two chips and effectively form a Faraday-Cage around the qubits, control signal waveguides etc. The qubit chip has strategically spaced qubits and an inductively coupled probe line and the wiring chip has a bus coupling resonator with a number of voltage nodes and anti-nodes, a resonator pump and at least one SQUID. Magnetic flux applied through the SQUIDs changes their impedances and modifies the microwave boundary conditions of the bus. This allows in-situ shifting of electric field distributions of the resonance modes of the bus along the length of the bus. This tunes the coupling rates of the bus to all qubits simultaneously.
FILED Thursday, November 04, 2021
APPL NO 17/519320
CURRENT CPC
Measuring Electric Variables; Measuring Magnetic Variables
G01R 33/0358 (20130101)

Computer Systems Based on Specific Computational Models
G06N 10/40 (20220101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138872 Vaagensmith et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
Idaho National Laboratory (INL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Energy Alliance, LLC (BEA) at Idaho Falls, ID
APPLICANT(S) Battelle Energy Alliance, LLC (Idaho Falls, Idaho)
ASSIGNEE(S)
INVENTOR(S) Bjorn C. Vaagensmith (Idaho Falls, Idaho);  Jesse L. Reeves (Ammon, Idaho);  James R. Case (Ammon, Idaho);  Timothy R. McJunkin (Idaho Falls, Idaho);  Kurt G. Vedros (Ammon, Idaho);  Liam D. Boire (Idaho Falls, Idaho);  Jason A. Wayment (Idaho Falls, Idaho);  Craig G. Rieger (Pocatello, Idaho)
ABSTRACT Described are systems, methods and devices for computer-aided infrastructure assessment. Some embodiments relate to computer-aided assessment of infrastructure using combinations of probabilistic risk assessment, resource delivery simulation, and physics-based resilience analysis.
FILED Tuesday, August 20, 2019
APPL NO 17/269448
CURRENT CPC
Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/0635 (20130101)
G06Q 50/06 (20130101) Original (OR) Class

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 3/00 (20130101)
H02J 2203/20 (20200101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220139579 ALESHIN et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
APPLICANT(S) Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania)
ASSIGNEE(S) Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania)
INVENTOR(S) Yuriy ALESHIN (Cayce, South Carolina);  Alex LEVINSKY (Pittsburgh, Pennsylvania)
ABSTRACT An adjustable core assembly for a nuclear reactor is disclosed herein. The adjustable core can include a plurality of reactivity control cells configured to accommodate a reactivity control rod, and a plurality of unit cells. The plurality of unit cells defines a radial dimension corresponding to an initial power output of the core. Each unit cell of the plurality of unit cells is configured to accommodate fuel configured to generate energy and a heat pipe configured to transfer thermal energy away from the core. Each unit cell of the plurality unit cells can be coupled to an adjacent unit cell in a radial direction, thereby altering the radial dimension, wherein the altered radial dimension corresponds to an adjusted power output of the core, and wherein the adjusted power output of the core is different than the initial power output of the core.
FILED Thursday, October 29, 2020
APPL NO 17/084365
CURRENT CPC
Nuclear Reactors
G21C 7/36 (20130101)
G21C 7/103 (20130101) Original (OR) Class
G21C 15/257 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220139582 LEVINSKY et al.
FUNDED BY
Department of Energy (DOE)
Office of Nuclear Energy (DOE-NE)
APPLICANT(S) Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania)
ASSIGNEE(S) Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania)
INVENTOR(S) Alex LEVINSKY (Pittsburgh, Pennsylvania);  Yuriy ALESHIN (Cayce, South Carolina);  Alexander W. HARKNESS (Allison Park, Pennsylvania)
ABSTRACT A configurable unit cell of a core of a nuclear reactor is disclosed herein. The configurable unit cell includes a core block material and a plurality of interchangeable components configured to affect a performance parameter of the core of the nuclear reactor. The configurable unit cell further includes a plurality of channels defined within the core block material. Each channel of the plurality of channels is configured to engage an interchangeable component of the plurality of interchangeable components in an operating configuration. Each channel of the plurality of channels is separated from an adjacent channel of the plurality of channels by a predetermined pitch.
FILED Thursday, October 29, 2020
APPL NO 17/084403
CURRENT CPC
Nuclear Reactors
G21C 19/205 (20130101) Original (OR) Class

Nuclear Power Plant
G21D 3/002 (20190101)
G21D 3/04 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140161 STRADINS et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
National Renewable Energy Laboratory (NREL)
Federally Funded Research and Development Center (FFRDC)
Operated by Alliance for Sustainable Energy, LLC (ASE) at Golden, CO
APPLICANT(S) Alliance for Sustainable Energy, LLC (Golden, Colorado)
ASSIGNEE(S)
INVENTOR(S) Pauls STRADINS (Golden, Colorado);  William Michael NEMETH (Wheat Ridge, Colorado);  David Levi YOUNG (Golden, Colorado);  Caroline Lima Salles de SOUZA (Golden, Colorado)
ABSTRACT The present disclosure relates to a passivating contact that includes a dielectric layer constructed of a first material, an intervening layer constructed of a second material, and a substrate constructed of a semiconductor, where the dielectric layer is positioned between the substrate and the intervening layer, the dielectric layer has a first thickness, and the substrate has a second thickness. The passivating contact also includes a plurality of conductive pathways that include the second material and pass through the first thickness, the second material penetrates into the second thickness forming a plurality of penetrating regions within the substrate, and the plurality of conductive pathways are configured to allow current to pass through the first thickness.
FILED Monday, November 01, 2021
APPL NO 17/516533
CURRENT CPC
Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 29/456 (20130101)
H01L 31/1868 (20130101)
H01L 31/022441 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140601 Vyakaranam et al.
FUNDED BY
Department of Energy (DOE)
Office of Science (DOE-SC)
Pacific Northwest National Laboratory (PNNL)
Federally Funded Research and Development Center (FFRDC)
Operated by Battelle Memorial Institute (BMI) at Richland, WA
APPLICANT(S) Battelle Memorial Institute (Richland, Washington)
ASSIGNEE(S) Battelle Memorial Institute (Richland, Washington)
INVENTOR(S) Bharat GNVSR Vyakaranam (Redmond, Washington);  Tony B. Nguyen (Richland, Washington);  Quan H. Nguyen (Richland, Washington);  Nader A. Samaan (Richland, Washington);  Mallikarjuna R. Vallem (Richland, Washington);  Renke Huang (Richland, Washington)
ABSTRACT A computer-implemented method includes extending simulation results and input data of a DC production cost model (PCM) of a power grid to an initial AC power flow model (PFM) using a generation distribution mapping and load distribution mapping of a related PFM base example associated with the PCM, and automatically producing a chronological series of converged AC PFM solutions associated with a PCM time series by, for each time step of the PCM time series: (i) updating inputs of an AC PFM using (a) PCM results of the current time step and (b) solution outputs of a converged AC PFM obtained from a previous PCM time step, and (ii) iteratively, reducing nodal loads by a gradual amount configured to account for power grid power flow losses unaccounted for by the PCM and performing AC PFM numerical analyses, until: (a) an AC PFM convergence is obtained and (b) a real power generation slack bus is less than or equal to a predefined tolerance in relation to a slack bus of the PCM results of the current time step.
FILED Wednesday, November 03, 2021
APPL NO 17/518478
CURRENT CPC
Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/06 (20130101)

Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy
H02J 3/003 (20200101) Original (OR) Class
H02J 3/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140700 Joshi et al.
FUNDED BY
Department of Energy (DOE)
Advanced Research Projects Agency - Energy (ARPA-E)
APPLICANT(S) Georgia Tech Research Corporation (Atlanta, Georgia)
ASSIGNEE(S)
INVENTOR(S) Yogendra K. Joshi (Atlanta, Georgia);  Wenming Li (Atlanta, Georgia)
ABSTRACT A cooling system for an electric motor that includes a stator having a plurality of slot windings and a rotor, coaxial with the stator, having a plurality of magnets, includes a coolant inlet to the motor and a coolant outlet from the motor. A coolant pathway is in fluid communication with the inlet and the outlet. Heat is transferable from the slot windings to the coolant pathway. A coolant flows through the coolant pathway and is in a liquid phase as it enters the coolant inlet, changing into a gaseous phase as heat is transferred to the coolant from the slot windings. A cooling loop is in fluid communication with the coolant inlet and the coolant outlet. The cooling loop cools the coolant so that substantially all of the coolant is in the liquid phase when it enters the coolant inlet.
FILED Monday, December 20, 2021
APPL NO 17/556403
CURRENT CPC
Dynamo-electric Machines
H02K 3/24 (20130101)
H02K 5/203 (20210101)
H02K 9/197 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140712 Sudhoff et al.
FUNDED BY
Department of Energy (DOE)
Office of Energy Efficiency and Renewable Energy (EERE)
APPLICANT(S) Purdue Research Foundation (West Lafayette, Indiana)
ASSIGNEE(S) Purdue Research Foundation (West Lafayette, Indiana)
INVENTOR(S) Scott Sudhoff (West Lafayette, Indiana);  Jiazhou Zhong (West Lafayette, Indiana);  Steve Pekarek (West Lafayette, Indiana)
ABSTRACT A homopolar alternating current machine (HAM) is disclosed which includes a stator having a plurality of segments radially protruding outward, each segment includes a main winding, a first auxiliary winding, and a second auxiliary winding, whereby each of the first and second auxiliary windings are coupled to each other in a parallel manner, a first rotor disposed proximate the stator, a second rotor disposed proximate the stator, and a dc flux source corresponding to each of the first and second rotors, whereby substantially no excitation of the first and the second auxiliary windings of each stator segment of the plurality of segments is needed to operate the HAM, whereby when energized, there is substantially no DC flux in each of the main winding, wherein operating the HAM results in a substantially sinusoidal current waveform without a DC offset, and wherein the HAM can be operated as a motor or generator.
FILED Saturday, October 30, 2021
APPL NO 17/515460
CURRENT CPC
Dynamo-electric Machines
H02K 1/148 (20130101)
H02K 3/28 (20130101)
H02K 19/18 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

National Aeronautics and Space Administration (NASA) 

US 20220134655 Townsend et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
John F. Kennedy Space Center (KSC)
APPLICANT(S) Sidus Space, Inc. (Merritt Island, Florida)
ASSIGNEE(S) Sidus Space, Inc. (Merritt Island, Florida)
INVENTOR(S) Ivan Townsend (Kennedy Space Center, Florida);  Robert Mueller (Kennedy Space Center, Florida);  Nathan Gelino (Kennedy Space Center, Florida);  Jonathan Smith (Kennedy Space Center, Florida);  Matthew Nugent (Kennedy Space Center, Florida);  Andrew Nick (Kennedy Space Center, Florida);  Jason Schuler (Kennedy Space Center, Florida);  Bradley Buckles (Kennedy Space Center, Florida)
ABSTRACT A three-dimensional print head apparatus may include a securing mechanism, a hopper, a nozzle, a heating system, and a fume extraction system. The securing mechanism may be adapted to secure to a wrist joint of a robotic arm. The hopper may have a cavity and a lower aperture and may be secured to the securing mechanism. The nozzle may have an upper aperture and a lower aperture. The heating system may be positioned along the barrel.
FILED Friday, January 14, 2022
APPL NO 17/648044
CURRENT CPC
Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing
B29C 64/118 (20170801)
B29C 64/209 (20170801) Original (OR) Class
B29C 64/329 (20170801)
B29C 64/364 (20170801)
B29C 64/393 (20170801)

Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering
B33Y 30/00 (20141201)
B33Y 50/02 (20141201)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135412 Waterman et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
National Science Foundation (NSF)
Directorate for Mathematical and Physical Sciences (MPS)
Division of Chemistry (CHE)
APPLICANT(S) University of Vermont and State Agricultural College (Burlington, Vermont)
ASSIGNEE(S)
INVENTOR(S) Rory Waterman (Burlington, Vermont);  Brandon Ackley (Burlington, Vermont)
ABSTRACT Methods of making a ceramic of a Group 13-15 type or a Group 13-15-16 type by thermolyzing a discrete molecular precursor to the ceramic in an oxygen-containing atmosphere. In some embodiments, the discrete molecular precursor is bench-stable and comprises a Lewis acid-base pair or small cyclic compound containing at last one Group 13 element and at least one Group 15 element but does not include indium and phosphorus in combination with one another unless a Group 16 element is present. The thermolysis can be carried out in air, at atmospheric pressure, and at a temperature below about 400° C., if desired. In some embodiments, the discrete molecular precursor can be placed in a mold having a desired shape and the thermolysis performed while the discrete molecular precursor is in the mold so as to produce a ceramic product having the desired shape.
FILED Tuesday, February 11, 2020
APPL NO 17/433276
CURRENT CPC
Non-metallic Elements; Compounds Thereof;
C01B 25/087 (20130101)
C01B 35/04 (20130101)
C01B 35/14 (20130101) Original (OR) Class

Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds
C01P 2002/88 (20130101)
C01P 2004/03 (20130101)
C01P 2006/40 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135925 Reiserer et al.
FUNDED BY
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
National Institute of Child Health and Human Development (NICHD)
National Institute of Neurological Disorders and Stroke (NINDS)
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
National Science Foundation (NSF)
Directorate for Biological Sciences (BIO)
Division of Biological Infrastructure (DBI)
Directorate for Engineering (ENG)
Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET)
APPLICANT(S) VANDERBILT UNIVERSITY (Nashville, Tennessee)
ASSIGNEE(S)
INVENTOR(S) Ronald S. Reiserer (Nashville, Tennessee);  Gregory B. Gerken (Nashville, Tennessee);  David K. Schaffer (Nashville, Tennessee);  John P. Wikswo (Brentwood, Tennessee)
ABSTRACT A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes.
FILED Wednesday, January 19, 2022
APPL NO 17/578966
CURRENT CPC
Apparatus for Enzymology or Microbiology;
C12M 23/08 (20130101)
C12M 23/10 (20130101)
C12M 23/12 (20130101)
C12M 23/16 (20130101)
C12M 23/50 (20130101)
C12M 23/58 (20130101)
C12M 27/02 (20130101)
C12M 27/12 (20130101)
C12M 29/10 (20130101) Original (OR) Class
C12M 35/02 (20130101)
C12M 35/04 (20130101)
C12M 41/48 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136779 Chen et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Jet Propulsion Laboratory (JPL)
Federally Funded Research and Development Center (FFRDC)
Operated by California Institute of Technology (CALTECH) at Pasadena, CA
APPLICANT(S) California Institute of Technology (Pasadena, California)
ASSIGNEE(S) California Institute of Technology (Pasadena, California)
INVENTOR(S) Weibo Chen (Pasadena, California);  Benjamin I. Furst (Pasadena, California);  Scott N. Roberts (Altadena, California)
ABSTRACT Systems and methods for thermal management using separable heat pipes and methods of manufacture thereof. Various embodiments provide a porous insert that can be used to join or connect heat pipes. Further embodiments provide thermal management systems that are modular, expandable, reparable, by allowing for joining of evaporators, condensers, and adiabatic sections via porous inserts. Various embodiments allow for two-phase thermal management systems, where liquid and gaseous phases can be transported simultaneously. Certain embodiments incorporate heat generating components with embedded evaporators and/or condensers. Many embodiments are additively manufactured, including via 3D printing.
FILED Tuesday, November 02, 2021
APPL NO 17/453332
CURRENT CPC
Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact
F28D 15/04 (20130101)
F28D 15/0241 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136950 Miller-Lionberg et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
Glenn Research Center (GLENN)
NASA Shared Services Center (NSSC)
APPLICANT(S) Colorado State University Research Foundation (Frort Collins, Colorado);  Access Sensor Technologies LLC (Frort Collins, Colorado)
ASSIGNEE(S)
INVENTOR(S) Daniel D. Miller-Lionberg (Denver, Colorado);  Casey W. Quinn (Olympia, Washington);  Christian C. L'Orange (Fort Collins, Colorado);  Jeffrey R. Pierce (Fort Collins, Colorado);  Eric A. Wendt (Fort Collins, Colorado);  John Volckens (Fort Collins, Colorado)
ABSTRACT In certain embodiments, a portable atmospheric monitor comprises a housing at least partially enclosing an inner chamber. The housing comprises an inlet and an aperture. The monitor also includes at least one light sensor arranged within the housing. The light sensor that senses one or more wavelengths of sunlight received via the aperture. The monitor includes at least one light-scattering sensor that senses PM received via the inlet. The monitor includes a processor arranged within the housing and coupled to the at least one light sensor and the at least one light-scattering sensor. The processor is configured to: receive a light signal from the at least one light sensor; receive a PM signal from the at least one light-scattering sensor; determine the aerosol optical depth based upon the light signal; and determine the PM concentration based upon the PM signal.
FILED Thursday, April 09, 2020
APPL NO 17/602147
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 15/06 (20130101) Original (OR) Class
G01N 21/53 (20130101)
G01N 2001/2223 (20130101)

Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags
G01V 8/10 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140494 Freebury et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) TENDEG LLC (Louisville, Colorado)
ASSIGNEE(S) TENDEG LLC (Louisville, Colorado)
INVENTOR(S) Gregg E. Freebury (Louisville, Colorado);  Matthew Phillip Mitchell (Colorado Springs, Colorado)
ABSTRACT An antenna having a reflector mounted on a rigid boom uses a line feed or phased array feed to operate in the Ka band with frequencies up to 36 gigahertz while maintaining the ability to operate at frequencies down to L-Band of 1-2 GHz.
FILED Friday, January 07, 2022
APPL NO 17/571115
CURRENT CPC
Antennas, i.e Radio Aerials
H01Q 15/14 (20130101) Original (OR) Class
H01Q 15/141 (20130101)
H01Q 15/147 (20130101)
H01Q 15/161 (20130101)
H01Q 15/162 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Small Business Administration (SBA) 

US 20220136986 Motes, III et al.
FUNDED BY
Department of Defense (DOD)
Department of the Air Force (DAF)
Air Force Research Laboratory (AFRL)
MATERIALS and MANUFACTURING DIRECTORATE (MMD)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) Texas Research International, Inc. (Austin, Texas)
ASSIGNEE(S)
INVENTOR(S) Doyle T. Motes, III (Austin, Texas);  Marcus Keiser (Cedar Park, Texas);  Richard Piner (Austin, Texas)
ABSTRACT Non-destructive sensing methods and devices for inspection and measuring in manufacturing applications for removal of contaminants from composite surfaces coupled with sensing and activation of the composite surfaces.
FILED Friday, September 10, 2021
APPL NO 17/472533
CURRENT CPC
Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 23/225 (20130101)
G01N 23/2202 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220137386 Weida et al.
FUNDED BY
National Science Foundation (NSF)
Directorate of Technology
Translational Impacts (TI)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) DAYLIGHT SOLUTIONS, INC. (San Diego, California)
ASSIGNEE(S)
INVENTOR(S) Miles James Weida (Poway, California);  Timothy Day (Poway, California)
ABSTRACT An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.
FILED Wednesday, January 19, 2022
APPL NO 17/579015
CURRENT CPC
Optical Elements, Systems, or Apparatus
G02B 21/00 (20130101)
G02B 21/0056 (20130101) Original (OR) Class
G02B 21/0088 (20130101)
G02B 21/088 (20130101)
G02B 21/365 (20130101)

Pictorial Communication, e.g Television
H04N 5/33 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220139031 Young et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
U.S. Army Contracting Command (ACC)
Redstone Arsenal (REDSTONE)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
Department of Transportation (USDOT)
Federal Highway Administration (FHWA)
National Highway Traffic Safety Administration (NHTSA)
APPLICANT(S) TRX Systems, Inc. (Greenbelt, Maryland)
ASSIGNEE(S)
INVENTOR(S) Travis Young (Rockville, Maryland);  Daniel Hakim (Silver Spring, Maryland);  Daniel Franchy (Catonsville, Maryland);  Jared Napora (Severn, Maryland);  John Karvounis (Bowie, Maryland);  Jonathan Fetter Degges (Washington, District of Columbia);  Tim Wang (Germantown, Maryland);  Benjamin Funk (Hanover, Maryland);  Carole Teolis (Glendale, Maryland);  Carol Politi (Bethesda, Maryland);  Stuart Woodbury (Ellicott City, Maryland)
ABSTRACT Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device.
FILED Wednesday, September 15, 2021
APPL NO 17/475935
CURRENT CPC
Electric Digital Data Processing
G06F 30/13 (20200101)

Image Data Processing or Generation, in General
G06T 17/05 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220140494 Freebury et al.
FUNDED BY
National Aeronautics and Space Administration (NASA)
NASA Shared Services Center (NSSC)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
APPLICANT(S) TENDEG LLC (Louisville, Colorado)
ASSIGNEE(S) TENDEG LLC (Louisville, Colorado)
INVENTOR(S) Gregg E. Freebury (Louisville, Colorado);  Matthew Phillip Mitchell (Colorado Springs, Colorado)
ABSTRACT An antenna having a reflector mounted on a rigid boom uses a line feed or phased array feed to operate in the Ka band with frequencies up to 36 gigahertz while maintaining the ability to operate at frequencies down to L-Band of 1-2 GHz.
FILED Friday, January 07, 2022
APPL NO 17/571115
CURRENT CPC
Antennas, i.e Radio Aerials
H01Q 15/14 (20130101) Original (OR) Class
H01Q 15/141 (20130101)
H01Q 15/147 (20130101)
H01Q 15/161 (20130101)
H01Q 15/162 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Agriculture (USDA) 

US 20220134579 CAO et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
ASSIGNEE(S) Board of Trustees of Michigan State University (East Lansing, Michigan)
INVENTOR(S) Changyong CAO (Okemos, Michigan);  Xiaobo TAN (Okemos, Michigan);  Yaokun PANG (East Lansing, Michigan);  Shoue CHEN (East Lansing, Michigan)
ABSTRACT A soft gripper apparatus is provided. In another aspect, a soft gripper includes tribo-skin pressure sensors, an internal bending sensor, at least one flexible gripping finger and an actuator. A further aspect of a soft gripper apparatus employs longitudinally elongated, laterally spaced apart and self-powering, electrically conductive strips that sense and send a bending signal to a programmable controller indicative of a bending angle of a gripping finger within which the strips are encapsulated. Another aspect of a gripping apparatus includes at least one workpiece pressure sensor and/or at least one bending sensor, which are connected to a programmable controller and electrical circuit to automatically determine a characteristic of the workpiece.
FILED Monday, November 01, 2021
APPL NO 17/515628
CURRENT CPC
Manipulators; Chambers Provided With Manipulation Devices
B25J 13/081 (20130101)
B25J 13/087 (20130101)
B25J 15/10 (20130101)
B25J 15/12 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220135902 CERMAK et al.
FUNDED BY
Department of Agriculture (USDA)
APPLICANT(S) The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) STEVEN C. CERMAK (GALESBURG, Illinois);  TERRY ISBELL (ELMWOOD, Illinois);  BENJAMIN A. LOWERY (PRINCEVILLE, Illinois)
ABSTRACT The invention relates to methods for the synthesis of hydroxy fatty acids from unsaturated fatty acids via epoxidation and catalytic hydrogenation.
FILED Thursday, November 04, 2021
APPL NO 17/519162
CURRENT CPC
Fatty Acids From Fats, Oils or Waxes; Candles; Fats, Oils or Fatty Acids by Chemical Modification of Fats, Oils, or Fatty Acids Obtained Therefrom
C11C 3/126 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138219 Beckham et al.
FUNDED BY
Department of Homeland Security (DHS)
Science and Technology Directorate (DHS-S&T)
Department of Agriculture (USDA)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S) Tammy Beckham (Manhattan, Kansas);  Matthew Coats (Washington, District of Columbia);  John Korslund (Riverdale, Maryland);  Michelle Colby (Washington, District of Columbia);  James Wall (College Station, Texas);  Keith Biggers (College Station, Texas);  Melissa Berquist (College Station, Texas);  Austin Riddle (College Station, Texas);  Paul Bilnoski (College Station, Texas);  Derek Overby (Covington, Louisiana);  Graham Booker (College Station, Texas);  Lindsey Holmstrom (Manhattan, Kansas)
ABSTRACT A system and computerized method for monitoring and analyzing animal related data. In one embodiment, the system includes a processor and memory operable to identify a parameter related to animal management for species in a biological environment, aggregate animal related data from different sources about the parameter of the species, identify a baseline for the parameter, correlate the animal related data against the baseline to obtain correlated data, and analyze said correlated data to assess said animal management.
FILED Friday, January 07, 2022
APPL NO 17/571393
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 11/008 (20130101)
A01K 29/005 (20130101)

Electric Digital Data Processing
G06F 3/04847 (20130101)
G06F 16/26 (20190101) Original (OR) Class
G06F 16/29 (20190101)
G06F 40/106 (20200101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/10 (20130101)
G06Q 50/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Commerce (DOC) 

US 20220134331 Esch
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)
INVENTOR(S) Mandy Brigitte Esch (Gaithersburg, Maryland)
ABSTRACT A gravity flow micro-physiological article determines a physiological response to a drug and includes: supply chambers; a mixing chamber; and a liquid divider, wherein the divider divides fluid under gravitational force so that individual portions of the fluid independently include metabolites in a proportionate amount as physically determined by the liquid divider.
FILED Friday, October 29, 2021
APPL NO 17/513942
CURRENT CPC
Chemical or Physical Laboratory Apparatus for General Use
B01L 3/50273 (20130101) Original (OR) Class
B01L 3/502715 (20130101)
B01L 2400/0457 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/5038 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136106 Oh et al.
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California)
ASSIGNEE(S)
INVENTOR(S) Il-Kwon Oh (Suwon, South Korea);  Stacey F. Bent (Stanford, California)
ABSTRACT Advanced precursors for selective atomic layer deposition (ALD) of aluminum oxide (Al2O3) using self-assembled monolayers (SAM) are provided. Area selective atomic layer deposition (AS-ALD) is a highly sought-after strategy for the fabrication of next-generation electronics. Embodiments described herein provide a process of selective ALD of Al2O3 that achieves an excellent selectivity between an SAM-coated surface and non-coated surface by adopting one of several novel ALD precursors. Some embodiments further optimize process parameters (e.g., growth temperature, precursor partial pressure, precursor dosing time, purging time, reactant dosing time, and number of cycles) to further improve selectivity of the ALD precursor.
FILED Monday, November 01, 2021
APPL NO 17/516139
CURRENT CPC
Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General
C23C 16/403 (20130101)
C23C 16/45553 (20130101) Original (OR) Class

Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for
H01L 21/0228 (20130101)
H01L 21/02178 (20130101)
H01L 21/02205 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136967 Obeng
FUNDED BY
Department of Commerce (DOC)
National Institute of Standards and Technology (NIST)
APPLICANT(S) Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland)
ASSIGNEE(S)
INVENTOR(S) Yaw Samuel Obeng (Frederick, Maryland)
ABSTRACT Embodiments of the present invention relate to a system and method for detecting biological material on surfaces after decontamination with UV-C and with high sensitivity and having low detection limits while providing rapid and efficient response to accommodate high turnover. Embodiments of the present invention monitor the disinfection process by detecting changes in the electrical properties of surface-confined biological thin films photodegraded with UV-C radiation using microwaves (MW). MW sensing provides noninvasive, real-time detection of the electromagnetic properties of biological materials via concentrated electromagnetic fields, for which advantages include wide bandwidth, small size, and cost-effective fabrication.
FILED Friday, November 05, 2021
APPL NO 17/520116
CURRENT CPC
Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 2/28 (20130101)

Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/689 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 21/47 (20130101) Original (OR) Class
G01N 22/00 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Homeland Security (DHS) 

US 20220134146 Thompson et al.
FUNDED BY
Department of Homeland Security (DHS)
APPLICANT(S) The Government of The United States of America, as represented by the Secretary of Homeland Security (Wahsington, District of Columbia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S) William G. Thompson (Elizabeth City, North Carolina);  Mary Shalane Regan (Groton, Connecticut)
ABSTRACT A cover device for a regulator, which has a purge button and a mouthpiece connected to the regulator, includes a body having a mouthpiece housing to receive the mouthpiece through an access opening which presents a friction fit to squeeze the mouthpiece passing therethrough in a squeezed state to enter and exit a hollow interior of the mouthpiece housing. The hollow interior is configured to store the mouthpiece in a relaxed state. A button cover is connected to the mouthpiece housing to cover the purge button on a top surface of the regulator when the mouthpiece is inserted into the hollow interior of the mouthpiece housing. The button cover is narrower in width than the mouthpiece housing.
FILED Thursday, December 02, 2021
APPL NO 17/541100
CURRENT CPC
Devices, Apparatus or Methods for Life-saving
A62B 9/06 (20130101)
A62B 25/00 (20130101) Original (OR) Class

Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects
B63C 11/186 (20130101)
B63C 11/2227 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138219 Beckham et al.
FUNDED BY
Department of Homeland Security (DHS)
Science and Technology Directorate (DHS-S&T)
Department of Agriculture (USDA)
APPLICANT(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
ASSIGNEE(S) The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia)
INVENTOR(S) Tammy Beckham (Manhattan, Kansas);  Matthew Coats (Washington, District of Columbia);  John Korslund (Riverdale, Maryland);  Michelle Colby (Washington, District of Columbia);  James Wall (College Station, Texas);  Keith Biggers (College Station, Texas);  Melissa Berquist (College Station, Texas);  Austin Riddle (College Station, Texas);  Paul Bilnoski (College Station, Texas);  Derek Overby (Covington, Louisiana);  Graham Booker (College Station, Texas);  Lindsey Holmstrom (Manhattan, Kansas)
ABSTRACT A system and computerized method for monitoring and analyzing animal related data. In one embodiment, the system includes a processor and memory operable to identify a parameter related to animal management for species in a biological environment, aggregate animal related data from different sources about the parameter of the species, identify a baseline for the parameter, correlate the animal related data against the baseline to obtain correlated data, and analyze said correlated data to assess said animal management.
FILED Friday, January 07, 2022
APPL NO 17/571393
CURRENT CPC
Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals
A01K 11/008 (20130101)
A01K 29/005 (20130101)

Electric Digital Data Processing
G06F 3/04847 (20130101)
G06F 16/26 (20190101) Original (OR) Class
G06F 16/29 (20190101)
G06F 40/106 (20200101)

Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/10 (20130101)
G06Q 50/02 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Veterans Affairs (DVA) 

US 20220133957 Boden et al.
FUNDED BY
Department of Veterans Affairs (DVA)
APPLICANT(S) Emory University (Atlanta, Georgia);  The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Scott D. Boden (Atlanta, Georgia);  Steven M. Presciutti (Decatur, Georgia);  Sreedhara Sangadala (Marietta, Georgia)
ABSTRACT This disclosure relates to sclerostin inhibitors for use in ossification, and methods related thereto. In certain embodiments, the disclosure relates to placing sclerostin inhibitors in graft compositions for forming bone. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a graft composition disclosed herein optionally comprising a growth factor such as BMP or recombinant vector expressing the same in a subject such as at a desired site of bone or cartilage growth.
FILED Tuesday, February 04, 2020
APPL NO 17/428556
CURRENT CPC
Preparations for Medical, Dental, or Toilet Purposes
A61K 31/19 (20130101)
A61K 31/506 (20130101)

Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles
A61L 27/24 (20130101)
A61L 27/52 (20130101)
A61L 27/54 (20130101) Original (OR) Class
A61L 27/227 (20130101)
A61L 2300/21 (20130101)
A61L 2300/204 (20130101)
A61L 2300/252 (20130101)
A61L 2300/414 (20130101)
A61L 2430/02 (20130101)
A61L 2430/06 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220136059 Czyzyk-Krzeska et al.
FUNDED BY
Department of Defense (DOD)
Department of the Army (DOA)
U.S. Army Medical Research and Materiel Command (USAMRMC)
Department of Veterans Affairs (DVA)
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
National Cancer Institute (NCI)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of General Medical Sciences (NIGMS)
APPLICANT(S) University of Cincinnati (Cincinnati, Ohio)
ASSIGNEE(S) University of Cincinnati (Cincinnati, Ohio)
INVENTOR(S) Maria Franciszka Czyzyk-Krzeska (Cincinnati, Ohio);  Julio Alberto Landero Figueroa (Cincinnati, Ohio);  Jarek Meller (Cincinnati, Ohio);  David Plas (Cincinnati, Ohio);  Shuchi Gulati (Cincinnati, Ohio);  Bhargav Vemuri (Mason, Ohio);  John Thomas Cunningham, IV (Maineville, Ohio)
ABSTRACT A method of diagnosing the likelihood of recurrence of clear cell renal cell carcinoma is provided. The method involves a) detecting the gene expression signatures of mitochondrial electron transport chain subunits, mitochondrial ribosomal proteins, major histocompatibility complex class II (MHC-II) proteins or combinations thereof in a kidney tumor tissue sample; and b) determining that the subject has an elevated risk of recurrence of clear cell renal cell carcinoma if the gene expression signatures include certain sequences. In another embodiment, the method uses copper levels to diagnose the likelihood of recurrence of clear cell renal cell carcinoma.
FILED Friday, May 21, 2021
APPL NO 17/327100
CURRENT CPC
Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes
C12Q 1/6886 (20130101) Original (OR) Class
C12Q 2600/118 (20130101)
C12Q 2600/158 (20130101)

Investigating or Analysing Materials by Determining Their Chemical or Physical Properties
G01N 33/57438 (20130101)
G01N 2333/90216 (20130101)
VIEW PATENT @ USPTO:  Full Text   PDF 

United States Postal Service (USPS) 

US 20220135276 Lee, SR.
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) James Edward Lee, SR. (St. Leonard, Maryland)
ABSTRACT Embodiments of a reusable stackable shipping box are provided herein. The reusable stackable shipping box may be reused and cleaned without causing harm to the integrity of the box. In addition, the box is slightly tapered in shape such that the box may be stacked upon and within other boxes for ease in shipping and organization.
FILED Friday, January 14, 2022
APPL NO 17/576703
CURRENT CPC
Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages
B65D 5/001 (20130101) Original (OR) Class
B65D 5/10 (20130101)
B65D 5/14 (20130101)
B65D 5/0245 (20130101)
B65D 5/0281 (20130101)
B65D 5/4266 (20130101)
B65D 5/4608 (20130101)
B65D 5/48024 (20130101)

Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management
Y02W 30/80 (20150501)
VIEW PATENT @ USPTO:  Full Text   PDF 
US 20220138891 IRWIN
FUNDED BY
United States Postal Service (USPS)
APPLICANT(S) United States Postal Service (Washington, District of Columbia)
ASSIGNEE(S)
INVENTOR(S) Donald E. IRWIN (Fredericksburg, Virginia)
ABSTRACT A system including a processor and a non-transitory computer-readable medium communicatively coupled to the processor and storing instructions executable by the processor is provided. When executed, the instructions cause the processor to receive, from a user, a rideshare request comprising an origination point and a destination location, determine that one or more parcels destined for delivery to the user are available for collection, identify, based on a collection location associated with each of the one or more parcels and at least one of the origination point and the destination location, a route that enables collection of at least one of the one or more parcels, and direct a rideshare operator to the collection location associated with at least one of the one or more parcels.
FILED Friday, October 22, 2021
APPL NO 17/508240
CURRENT CPC
Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for
G06Q 10/02 (20130101)
G06Q 50/32 (20130101) Original (OR) Class
VIEW PATENT @ USPTO:  Full Text   PDF 

Department of Transportation (USDOT) 

US 20220139031 Young et al.
FUNDED BY
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Department of the Army (DOA)
U.S. Army Contracting Command (ACC)
Redstone Arsenal (REDSTONE)
Small Business Administration (SBA)
Small Business Innovation Research (SBIR)
Department of Transportation (USDOT)
Federal Highway Administration (FHWA)
National Highway Traffic Safety Administration (NHTSA)
APPLICANT(S) TRX Systems, Inc. (Greenbelt, Maryland)
ASSIGNEE(S)
INVENTOR(S) Travis Young (Rockville, Maryland);  Daniel Hakim (Silver Spring, Maryland);  Daniel Franchy (Catonsville, Maryland);  Jared Napora (Severn, Maryland);  John Karvounis (Bowie, Maryland);  Jonathan Fetter Degges (Washington, District of Columbia);  Tim Wang (Germantown, Maryland);  Benjamin Funk (Hanover, Maryland);  Carole Teolis (Glendale, Maryland);  Carol Politi (Bethesda, Maryland);  Stuart Woodbury (Ellicott City, Maryland)
ABSTRACT Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device.
FILED Wednesday, September 15, 2021
APPL NO 17/475935
CURRENT CPC
Electric Digital Data Processing
G06F 30/13 (20200101)

Image Data Processing or Generation, in General
G06T 17/05 (20130101) Original (OR) Class
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