FedInvent™ Patent Applications
Application Details for Thursday, May 05, 2022
This page was updated on Sunday, May 08, 2022 at 03:42 PM GMT
Department of Health and Human Services (HHS)
| US 20220133139 | Mahadevan-Jansen et al. |
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| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anita Mahadevan-Jansen (Nashville, Tennessee); Giju Thomas (Nashville, Tennessee); Kamran Idrees (Nashville, Tennessee); Carmen Solorzano (Nashville, Tennessee); Parker Willmon (Nashville, Tennessee); Colleen Kiernan (Nashville, Tennessee) |
| ABSTRACT | The invention discloses systems and methods for providing anatomical guidance in surgery. The system includes a light source configured to emit light for illuminating tissues of a target region; means for obtaining autofluorescence signals emitted from the illuminated tissues in response to the illumination; and a controller configured to process the obtained autofluorescence signal to identify target tissues. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515748 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/0005 (20130101) A61B 1/07 (20130101) A61B 1/042 (20130101) A61B 1/063 (20130101) A61B 1/0638 (20130101) Original (OR) Class A61B 1/0646 (20130101) A61B 1/0684 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133159 | Ansari et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sardar Ansari (Ypsilanti, Michigan); Kenn Oldham (Ann Arbor, Michigan); Kevin R. Ward (Superior Township, Michigan); Kayvan Najarian (Northville, Michigan); Lu Wang (Ann Arbor, Michigan) |
| ABSTRACT | A method for noninvasively measuring hemodynamic variables of a person includes physically configuring a sensor to measure the pulse of a person. The sensor generates a pulse waveform indicative of the pulse of the person. A processor obtains the pulse waveform from the sensor and the processor determines a reflection coefficient and reflection delay between an incident and a reflected wave, from which the processor determines the hemodynamic variables of the person from the reflection coefficient and the reflection delay. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514939 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02116 (20130101) Original (OR) Class A61B 5/02125 (20130101) A61B 5/6819 (20130101) A61B 5/6822 (20130101) A61B 5/6823 (20130101) A61B 5/6824 (20130101) A61B 5/6826 (20130101) A61B 5/6828 (20130101) A61B 5/6829 (20130101) A61B 5/6831 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133167 | Barlow et al. |
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| APPLICANT(S) | Innara Health, Inc. (Olathe, Kansas) |
| ASSIGNEE(S) | Innara Health, Inc. (Olathe, Kansas); University of Kansas (Lawrence, Kansas) |
| INVENTOR(S) | Steven M. Barlow (Lawrence, Kansas); David L. Stalling (Olathe, Kansas); Kenneth Aron (Olathe, Kansas) |
| ABSTRACT | The present invention relates to methods of using a therapeutic system. In particular, the present invention relates to procedures and methods of using a system having hardware, software, and appliance components for assessing and entraining a non-nutritive suck (NNS) pattern in a patient. The methods include configuring the hardware and software systems to receive data from an orofacial stimulation appliance and to generate a precise therapeutic pulse profile that is actuated as a tactile stimulus. The methods also include collecting data using the orofacial stimulation appliance and delivering the tactile stimulus via the orofacial stimulation appliance to entrain an organized NNS pattern. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576745 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/038 (20130101) Original (OR) Class A61B 5/486 (20130101) A61B 5/682 (20130101) A61B 5/6896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133181 | Beni et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
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| INVENTOR(S) | Catherine Beni (Seattle, Washington); Barclay Stewart (Seattle, Washington); Jonathan Dov Posner (Seattle, Washington); Aman Garg (Seattle, Washington); Nelson Warner (Seattle, Washington); Kenneth Shim (Seattle, Washington); Yuan-Ni Yeh (Seattle, Washington) |
| ABSTRACT | Systems, devices, and methods to measure interstitial concentration of selected compounds over time to provide early detection of shock are described. In an example method, interstitial fluid is obtained from a subject. Analytes are detected in the interstitial fluid. At least one of the analytes corresponds to hypoxia of a tissue of the subject and at least one other analyte corresponds to vascular permeability of the subject. The example method further includes determining whether the subject is in shock based on a computing model and the detected analytes and generating an alert based on whether the subject is in shock. Treatments can be administered following the alert generation. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514941 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0004 (20130101) A61B 5/7282 (20130101) A61B 5/14514 (20130101) Original (OR) Class A61B 5/14546 (20130101) A61B 5/14735 (20130101) A61B 2010/008 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133205 | Efimov et al. |
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| FUNDED BY |
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| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Igor R. Efimov (Arlington, Virginia); Valentin I. Krinski (Villeneuve Loubet, France); Vladmir P. Nikolski (St. Anthony, Minnesota) |
| ABSTRACT | A method for extinguishing a cardiac arrhythmia utilizes destructive interference of the passing of the reentry wave tip of an anatomical reentry through a depolarized region created by a relatively low voltage electric field in such a way as to effectively unpin the anatomical reentry. Preferably, the relatively low voltage electric field is defined by at least one unpinning shock(s) that are lower than an expected lower limit of vulnerability as established, for example, by a defibrillation threshold test. By understanding the physics of the electric field distribution between cardiac cells, the method permits the delivery of an electric field sufficient to unpin the core of the anatomical reentry, whether the precise or estimated location of the reentry is known or unknown and without the risk of inducting ventricular fibrillation. A number of embodiments for performing the method are disclosed. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/454886 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/318 (20210101) Original (OR) Class A61B 5/363 (20210101) A61B 5/7239 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/3627 (20130101) A61N 1/3906 (20130101) A61N 1/3925 (20130101) A61N 1/3987 (20130101) A61N 1/39622 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133273 | DANGI et al. |
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| APPLICANT(S) | The Penn State Research Foundation (University Park, Pennsylvania) |
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| INVENTOR(S) | Ajay DANGI (University Park, Pennsylvania); Sumit AGRAWAL (University Park, Pennsylvania); Sri-Rajasekhar KOTHAPALLI (University Park, Pennsylvania) |
| ABSTRACT | The present disclosure provides photoacoustic-imaging techniques using an optically-transparent bulk piezoelectric ultrasound transducer. A PAI system is disclosed. The PAI system has an optically translucent piezoelectric substrate, and a light source capable of providing light through the transducer to a region of interest. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/429453 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 8/4416 (20130101) A61B 8/4444 (20130101) A61B 8/4483 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133474 | Bui et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); Georgia Institute of Technology (Atlanta, Georgia); Colorado State University Research Foundation (Fort Collins, Colorado) |
| ASSIGNEE(S) | Ohio State Innovation Foundation (Columbus, Ohio); Georgia Institute of Technology (Atlanta, Georgia); Colorado State University Research Foundation (Fort Collins, Colorado) |
| INVENTOR(S) | Hieu Bui (Lithia Springs, Georgia); Lakshmi Prasad Dasi (Dublin, Ohio); Megan Heitkemper (San Jose, California); Susan James (Bellvue, Colorado); Nipa Khair (Fort Collins, Colorado) |
| ABSTRACT | A transcatheter prosthetic heart valve includes a stent frame and a leaflet material. The stent frame includes a top portion and a bottom portion. The leaflet material includes a lower portion attached to the stent frame and an upper portion that includes leaflets capable of moving between an open configuration and a closed configuration. At least a portion of the leaflet material weaves through the stent frame. The transcatheter prosthetic heart valve also includes one or more reinforcement components coupled to the stent frame and/or to the leaflet material to enhance performance of the transcatheter heart valve. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/648076 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/2415 (20130101) A61F 2/2418 (20130101) Original (OR) Class A61F 2/2433 (20130101) A61F 2210/0004 (20130101) A61F 2240/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133509 | Segil et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Point Designs LLC (Lafayette, Colorado) |
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| INVENTOR(S) | Jacob Segil (Boulder, Colorado); Stephen Huddle (Thornton, Colorado); Levin Sliker (Boulder, Colorado); Richard Weir (Lafayette, Colorado) |
| ABSTRACT | Various embodiments of the present invention generally relate to prosthetic partial finger designs that can mimic the last two joints of the finger. Some embodiments include a proximal phalange, a distal phalange coupled to the proximal phalange, and a knuckle track (e.g., formed in an arc). The knuckle track can be moveably coupled to the proximal phalange an may include multiple teeth formed on which the proximal phalange slides along. A ratcheting mechanism can contact the multiple teeth to allow sliding in only a first direction while the ratcheting mechanism is engaged. Some embodiments include a release mechanism (e.g., a button) configured to disengage the ratcheting mechanism from the multiple teeth to allow the distal phalange to slide in a second direction. In some embodiments, the device may include a spring-back capability that automatically extends the finger after reaching full finger flexion, enabling one-handed use. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/571773 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/66 (20130101) A61F 2/72 (20130101) A61F 2/586 (20130101) Original (OR) Class A61F 2/5046 (20130101) A61F 2002/587 (20130101) A61F 2002/5038 (20130101) A61F 2002/5056 (20130101) A61F 2002/5072 (20130101) A61F 2002/6621 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133519 | Lerner et al. |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of Northern Arizona University (Flagstaff, Arizona) |
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| INVENTOR(S) | Zachary F Lerner (Flagstaff, Arizona); Grigoriy Orekhov (Flagstaff, Arizona); Leah Liebelt (Flagstaff, Arizona) |
| ABSTRACT | An assistive ankle foot orthosis is described. The AFO has a tubular vertical member arranged laterally to a user's limb. The member carries a rotational bearing and a rotational element such as a pulley. The pulley is connected to a footplate. The footplate provides joint movement assistance or resistance to the user upon rotation of the pulley. The pulley is coupled to one or more springs that provide counter-rotational resistance to pulley movement, thereby storing, and then returning, rotational force during certain foot movements. The spring can include a leaf spring arranged inside the member, the stiffness of which can be manually, automatically or dynamically adjusted by movement of the device. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/515300 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 5/0127 (20130101) Original (OR) Class A61F 2005/0155 (20130101) A61F 2005/0167 (20130101) A61F 2005/0179 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133637 | CHENG et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Qiang CHENG (Dallas, Texas); Tuo WEI (Dallas, Texas); Daniel J. SIEGWART (Dallas, Texas) |
| ABSTRACT | The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/572615 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5123 (20130101) Original (OR) Class A61K 48/0033 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/111 (20130101) C12N 15/113 (20130101) C12N 2310/20 (20170501) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133639 | Thayumanavan et al. |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
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| INVENTOR(S) | Sankaran Thayumanavan (Amherst, Massachusetts); Jiaming Zhuang (Amherst, Massachusetts); Hui Wang (Sunderland, Massachusetts) |
| ABSTRACT | The invention generally relates to polymer-based nano-structures. More particularly, the invention relates to novel, surface-functionalized, guest-host polymer nano-assemblies and nano-delivery vehicles useful in diverse fields including drug delivery, diagnostics and specialty materials. The nano-assemblies and nano-delivery vehicles of the invention are afforded via simplify and reliable approaches. |
| FILED | Saturday, July 31, 2021 |
| APPL NO | 17/390912 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5138 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 47/6903 (20170801) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133671 | Gomer et al. |
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| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Richard H. Gomer (College Station, Texas); Thomas Meek (College Station, Texas); Tejas Karhadkar (College Station, Texas); Darrell Pilling (Cypress, Texas) |
| ABSTRACT | The present disclosure relates to methods of preventing or inhibiting fibrosis using small molecule sialidase inhibitors. The present disclosure also relates to methods treating obesity, liver inflammation, steatosis, and cancer. These methods can involve administering the compounds to a patent at risk of developing fibrosis inflammation, obesity, steatosis, or cancer, in a manner that inhibits NEU3. |
| FILED | Monday, February 10, 2020 |
| APPL NO | 17/430287 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/60 (20130101) A61K 31/215 (20130101) Original (OR) Class A61K 31/351 (20130101) A61K 31/401 (20130101) A61K 31/445 (20130101) A61K 31/455 (20130101) A61K 31/4402 (20130101) A61K 31/4406 (20130101) A61K 31/4422 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133672 | Blatt et al. |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julie M. Blatt (Chapel HI!!, North Carolina); Reema B. Davis (Apex, North Carolina); Kristy Pahl (Chapel Hill, North Carolina); Kathleen Marie-lsabelle Caron (Chapel Hill, North Carolina); Scott Victor Smith (Cary, North Carolina); Carrie J. Shawber (Township of Washington, North Carolina) |
| ABSTRACT | The present disclosure provides a method to treat or ameliorate vascular malformations, developmental abnormalities of one or more types of blood or lymphatic vessels. These are rare disorders with life-long risk of high morbidity including cosmetic concerns, pain, infection, pulmonary emboli, bleeding and even death. Treatment is difficult, and there is growing interest in improved therapies. The disclosure provides specific compounds that are inhibitors of Notch receptor signaling. In some embodiments, the compounds disclosed are gamma secretase inhibitors (GSIs). |
| FILED | Wednesday, December 18, 2019 |
| APPL NO | 17/415813 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/55 (20130101) A61K 31/216 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 9/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133706 | MISCHEL et al. |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California); LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (Zurich, Switzerland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Paul S. MISCHEL (La Jolla, California); Bing REN (Del Mar, California); Vineet BAFNA (San Diego, California); Sudhir CHOWDHRY (San Diego, California) |
| ABSTRACT | There are provided, inter alia, methods for treatment of cancer. The methods include means of identifying the NAD biosynthetic pathway on which depend cancer cells in a tumor, in a subject suffering from cancer. The methods further include administering to a subject in need a therapeutically effective amount of an inhibitor of the NMRK1 enzyme pathway to a tumor where the cancer cells are dependent of the NAD salvage pathway, allowing to lower the of dose FK866 administered to the subject. The methods also include administering to a subject in need a therapeutically effective amount of a bacterial inhibitor of NADSYN1 to a tumor where the cancer cells depend on the Preiss Handler pathway. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/438610 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/63 (20130101) A61K 31/455 (20130101) A61K 31/4545 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133713 | Canney et al. |
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| APPLICANT(S) | Temple University-Of The Commonwealth System of Higher Education (Philadelphia, Pennsylvania) |
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| INVENTOR(S) | Daniel J. Canney (Ambler, Pennsylvania); Benjamin E. Blass (Eagleville, Pennsylvania); Rong Gao (Roscoe, Illinois); Kevin Blattner (Folsom, Pennsylvania) |
| ABSTRACT | Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity. |
| FILED | Monday, June 14, 2021 |
| APPL NO | 17/347253 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) Original (OR) Class A61K 31/4525 (20130101) A61K 31/4709 (20130101) A61K 31/4725 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 307/33 (20130101) C07D 307/94 (20130101) C07D 405/02 (20130101) C07D 405/06 (20130101) C07D 405/12 (20130101) C07D 405/14 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133715 | TYNER et al. |
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| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| INVENTOR(S) | JEFFREY TYNER (Portland, Oregon); TAMILLA NECHIPORUK (Portland, Oregon); STEPHEN KURTZ (Portland, Oregon); SHANNON MCWEENY (Portland, Oregon) |
| ABSTRACT | The present invention concerns novel methods of treatment for venetoclax-resistant acute myeloid leukemia, particularly in subjects with a low expression of TP53 protein or expression of TP53 protein associated with a mutation of the TP53 gene, the methods comprising administering to the subject in need thereof a therapeutically effective amount of a NTRK/ALK/ROS1 inhibitor, or a pharmaceutically acceptable salt thereof. |
| FILED | Wednesday, February 26, 2020 |
| APPL NO | 17/434278 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/496 (20130101) Original (OR) Class A61K 31/506 (20130101) A61K 31/635 (20130101) A61K 31/4545 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133730 | Zuo et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| ASSIGNEE(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Tal Teitz (Omaha, Nebraska) |
| ABSTRACT | Method, kit and pharmaceutical compositions using an inhibitor of EGFR signaling for prevention or treatment of hearing loss are described. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/580755 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/4439 (20130101) A61K 31/4709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133746 | PAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Deng PAN (Chicago, Illinois); Masha KOCHERGINSKY (Chicago, Illinois); Suzanne D. CONZEN (Park Ridge, Illinois) |
| ABSTRACT | Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 17/577882 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/282 (20130101) A61K 31/337 (20130101) A61K 31/357 (20130101) A61K 31/567 (20130101) A61K 31/575 (20130101) Original (OR) Class A61K 31/4745 (20130101) A61K 31/7068 (20130101) A61K 33/243 (20190101) A61K 39/3955 (20130101) A61K 45/06 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133747 | Pietras et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
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| INVENTOR(S) | Richard J. Pietras (Sherman Oaks, California); Michael E. Jung (Los Angeles, California) |
| ABSTRACT | Described herein, inter alia, are compositions and methods for treating or preventing hyperproliferative disorders, including cancer. |
| FILED | Thursday, June 06, 2019 |
| APPL NO | 15/734199 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) Original (OR) Class A61K 31/565 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133756 | RADTKE |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (Baltimore, Maryland) |
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| INVENTOR(S) | KATHERINE L. RADTKE (BALTIMORE, Maryland) |
| ABSTRACT | The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/569804 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/675 (20130101) A61K 31/683 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133760 | Sarthy et al. |
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| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| INVENTOR(S) | Jay Francis Sarthy (Seattle, Washington); Antoine Molaro (Clermont-Ferrand, France); Marie Bleakley (Seattle, Washington); Guo-Liang Chew (Singapore, Singapore) |
| ABSTRACT | The present disclosure describes methods of treating lymphoma that expresses a short histone H2A variant. In some embodiments, the method can comprise collecting a sample from a subject having or suspected of having lymphoma, detecting a short histone H2A variant (sH2A) expression level in the sample collected from the subject, and administering to the subject a therapeutically effective dose of an anthracycline agent, if the subject has sH2A variant expression level that is detectable. In other embodiments, the sH2A is the H2A.B variant. In other embodiments, the anthracycline agent can be aclarubicin. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516600 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/136 (20130101) A61K 31/704 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133761 | WANG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | WASHINGTON STATE UNIVERSITY (Pullman, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zhenjia WANG (Spokane, Washington); Canyang ZHANG (Pullman, Washington) |
| ABSTRACT | Disclosed are methods and compounds to selectively target the apoptosis pathway in proinflammatory neutrophils using Topoisomerase nanoparticles (NPs). The design of the disclosed nanoparticles (NPs) allows controlled release of DOX inside neutrophils, thus avoiding systemic toxicity. One such beneficial method for treating a subject neutrophil-inflammatory infection or tissue injury response includes administering a topoisomerase-conjugated albumin protein nanoparticles (NPs) composition to the subject, wherein the composition includes an effective amount so as to induce apoptosis of neutrophils, wherein the neutrophil induced inflammatory response is lower following the administration of the composition. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518031 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/704 (20130101) Original (OR) Class A61K 47/643 (20170801) A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133767 | SLACK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Frank SLACK (Waban, Massachusetts); Wen Cai ZHANG (Brookline, Massachusetts) |
| ABSTRACT | The invention provides methods and compositions for use in targeting micro RNAs (miRNAs), as well as methods and compositions for use in treating, reducing, inhibiting, or delaying resistance or tolerance to anti-cancer treatment, and methods and compositions for use in treating or preventing cancer. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 17/431474 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/506 (20130101) A61K 31/5377 (20130101) A61K 31/7088 (20130101) Original (OR) Class A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0693 (20130101) C12N 15/113 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2310/113 (20130101) C12N 2310/3231 (20130101) C12N 2320/31 (20130101) C12N 2501/06 (20130101) C12N 2503/02 (20130101) C12N 2513/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133770 | Karin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Karin (La Jolla, California); Elsa Sanchez-Lopez (La Jolla, California) |
| ABSTRACT | Provided herein are methods of treating macrophage-mediated inflammatory diseases and disorders. Also, disclosed are methods for screening for agents useful in such methods. |
| FILED | Tuesday, February 04, 2020 |
| APPL NO | 17/428544 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) Original (OR) Class A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133792 | SENTMAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles SENTMAN (Grantham, New Hampshire); David GRABER (Hanover, New Hampshire); W. James COOK (Hanover, New Hampshire) |
| ABSTRACT | Chimeric antigen receptors (CARs) are disclosed, along with nucleic acids and vectors encoding, and recombinant cells comprising such CARs and therapeutic compositions containing any of the foregoing. The CARs may comprise mutations that alter CAR expression, cytotoxicity, or cytokine production. Also provided are methods for using recombinant cells comprising these CARs for immunotherapy, e.g., in treating cancer by the administration of a therapeutically effective amount of one or more of the CAR polypeptides, nucleic acids, vectors, and/or immune cells, e.g., human CAR T cells, described herein optionally in combination with other immune and cancer treatments. |
| FILED | Friday, January 31, 2020 |
| APPL NO | 17/427117 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 14/70521 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133797 | Roybal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kole T. Roybal (San Francisco, California); Raymond Liu (San Francisco, California); Iowis Zhu (San Francisco, California) |
| ABSTRACT | The present disclosure generally relates to, inter alia, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. In addition, the new receptors described herein incorporate an extracellular oligomerization domain to promote oligomer formation of the chimeric receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as cancers. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/529091 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/705 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 16/32 (20130101) C07K 16/2803 (20130101) C07K 16/2878 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133818 | COLGAN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sean P. COLGAN (Foxfield, Colorado); Joseph Scott LEE (Denver, Colorado); Daniel J. KAO (Denver, Colorado) |
| ABSTRACT | Methods of treating, reducing the risk of, preventing, or alleviating a symptom of inflammation or inflammatory gastrointestinal disease by administration of a modified bacterium providing purines, in particular hypoxanthine, to the mucosa of the intestine, and compositions containing modified bacteria useful in such methods. |
| FILED | Wednesday, February 26, 2020 |
| APPL NO | 17/433713 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/745 (20130101) Original (OR) Class A61K 35/747 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133821 | Occhino et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John A. Occhino (Rochester, Minnesota); Marina R. Walther-Antonio (Rochester, Minnesota); Douglas Allan Leach (Chesapeake, Virginia) |
| ABSTRACT | Methods and materials involved in assessing and treating a mammal having a rectovaginal fistula (RVF) are provided herein. For example, the methods and materials described herein can be used for determining if a mammal having a RVF is likely to experience a successful outcome after surgical repair of the RVF, or if the mammal is likely to experience recurrence. Methods and materials for modulating the rectal and/or vaginal microbiome of mammal having a RVF also are provided herein. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/519186 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 33/135 (20160801) Preparations for Medical, Dental, or Toilet Purposes A61K 35/748 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133824 | Thorne et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Stephen Howard Thorne (Pittsburgh, Pennsylvania); Daniel J. Byrd (Pittsburgh, Pennsylvania) |
| ABSTRACT | This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/574691 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/768 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/07 (20130101) C07K 14/16 (20130101) C07K 14/4702 (20130101) C07K 16/2827 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/104 (20130101) C12N 15/625 (20130101) C12N 2710/24132 (20130101) C12N 2710/24143 (20130101) Enzymes C12Y 301/03048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133825 | Thorne et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Stephen Howard Thorne (Pittsburgh, Pennsylvania); Daniel J. Byrd (Pittsburgh, Pennsylvania) |
| ABSTRACT | This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that expresses a protein that modulates STAT3 activity. It is based, at least in part, on the discovery that vaccinia viruses modified to contain nucleic acid encoding PIAS3 and that express PIAS3 or a fragment thereof can inhibit STAT3 activity and enhance the anti-cancer activity of the vaccinia virus. Accordingly, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of cancers. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/574763 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 35/768 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/07 (20130101) C07K 14/16 (20130101) C07K 14/4702 (20130101) C07K 16/2827 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/16 (20130101) C12N 9/104 (20130101) C12N 15/625 (20130101) C12N 2710/24132 (20130101) C12N 2710/24143 (20130101) Enzymes C12Y 301/03048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133847 | Alles et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sascha Alles (Albuquerque, New Mexico); Karin Westlund High (Albuquerque, New Mexico) |
| ABSTRACT | A therapeutic composition includes a Cav3.3 inhibitor and a pharmaceutically acceptable carrier. In some embodiments the Cav3.3 inhibitor can include a polypeptide such as, for example, the amino acid sequence of SEQ ID NO:1, an antibody, or fragment thereof. In some embodiments, the Cav3.3 inhibitor can include an inhibitory polynucleotide such as, for example, an anti-sense oligonucleotide that either hybridizes to a portion of Cacnali or hybridizes to an RNA transcribed from a portion of Cacnali. The therapeutic composition can be administered to a subject to alleviate pain in the subject or to increase the subject's mechanical withdrawal threshold. The composition can be used to reduce Cav3.3 expression in a cell. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/517045 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/17 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Peptides C07K 16/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) C12N 2310/11 (20130101) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133848 | Eggan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin C. Eggan (Boston, Massachusetts); Joseph Robert Klim (Boston, Massachusetts); Francesco Limone (Cambridge, Massachusetts); Irune Guerra San Juan (Cambridge, Massachusetts); Luis Williams (Cambridge, Massachusetts) |
| ABSTRACT | The disclosure relates to compositions and methods for treating a disease or condition associated with a TDP-pathology or a decline in TDP-43 functionality in neuronal cells in a subject, and for identifying candidate agents to restore expression of a normal full-length or protein coding STMN2 RNA. |
| FILED | Tuesday, January 14, 2020 |
| APPL NO | 17/423104 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) A61K 38/1703 (20130101) Original (OR) Class A61K 48/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6851 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5058 (20130101) G01N 33/6896 (20130101) G01N 2800/28 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133859 | Yang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Otto O. Yang (Los Angeles, California); Yunfeng Lu (Culver City, California); Cheng Ji (Los Angeles, California); Ming Yan (Los Angeles, California); Yang Liu (Los Angeles, California) |
| ABSTRACT | The invention disclosed herein includes nanocomplexes that are designed include enzymes that have complementary functional attributes and methods for using these nanocomplexes. Illustrative examples include nanocomplexes that comprise both an alcohol oxidase enzyme as well as a catalase enzyme. These nanocomplexes can be used in methods designed to lower blood alcohol levels in vivo, and/or to break down the toxic byproducts of alcohol metabolism. Consequently these nanocomplexes can be used to treat a variety of conditions resulting from the consumption of alcohol, including for example, acute alcohol intoxication. |
| FILED | Friday, March 20, 2020 |
| APPL NO | 16/825806 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/44 (20130101) A61K 38/443 (20130101) Original (OR) Class A61K 47/64 (20170801) A61K 47/549 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 11/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133877 | Martinez-Sobrido et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Rochester (Rochester, New York); UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (Lexington, Kentucky); ZOETIS SERVICES LLC (Parsippany, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luis Martinez-Sobrido (Rochester, New York); Thomas Chambers (Lexington, Kentucky); Kendall Wayne King (Kalamazoo, Michigan) |
| ABSTRACT | The present invention provides compositions and methods related to equine live-attenuated influenza vaccines. In one aspect, the invention relates to a composition comprising a multivalent equine live-attenuated influenza vaccine comprising a first live-attenuated influenza virus expressing one or more antigens of a clade 1 H3N8 equine influenza virus; and a second live-attenuated influenza virus expressing one or more antigens of a clade 2 H3N8 equine influenza virus, wherein the second live-attenuated influenza virus expresses HA, NA, or a combination thereof of A/equine/Lancashire/1/2016 H3N8. |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 17/434489 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 2039/5254 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133887 | REIMANN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Beth Israel Deaconess Medical Center, Inc. (Boston, Massachusetts); Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Keith A. REIMANN (Marblehead, Massachusetts); Rijian WANG (Saugus, Massachusetts); Christian P. LARSEN (Atlanta, Georgia) |
| ABSTRACT | The present invention relates to antibodies specific for a particular epitope on CD40 and antibodies that bind CD40 and have particular functional characteristics. The present invention also relates to fragments of these antibodies, uses of the antibodies for reduction or treatment of transplant rejection and graft-versus-host disease, and methods for making the antibodies. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/573730 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/436 (20130101) A61K 38/13 (20130101) A61K 39/3955 (20130101) Original (OR) Class A61K 39/39541 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/06 (20180101) Peptides C07K 16/18 (20130101) C07K 16/2866 (20130101) C07K 16/2875 (20130101) C07K 16/2878 (20130101) C07K 2317/24 (20130101) C07K 2317/33 (20130101) C07K 2317/76 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133893 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yupeng Chen (Farmington, Connecticut); Jinhyung Lee (Farmington, Connecticut) |
| ABSTRACT | Disclosed herein is a delivery vehicle based on DNA-inspired Janus based nanotubes (JBNTs) for anti-viral treatment. The nanoparticles (NPs) are based the JBNTs conjugated with targeting moieties such as small molecules, aptamers, and peptides. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514390 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/51 (20130101) A61K 31/194 (20130101) A61K 31/519 (20130101) A61K 31/721 (20130101) A61K 31/722 (20130101) A61K 31/727 (20130101) A61K 31/728 (20130101) A61K 38/19 (20130101) A61K 38/40 (20130101) A61K 38/363 (20130101) A61K 38/385 (20130101) A61K 47/65 (20170801) A61K 47/545 (20170801) Original (OR) Class A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133896 | Duan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bin Duan (Omaha, Nebraska); Mitchell Kuss (Omaha, Nebraska); Tammy Kielian (LaVista, Nebraska); Amy Aldrich (Omaha, Nebraska); Wen Shi (Pappillion, Nebraska) |
| ABSTRACT | Three-dimensional printed antibiotic scaffolds are provided as well as methods of use thereof and methods of making. |
| FILED | Friday, March 06, 2020 |
| APPL NO | 17/431049 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 38/12 (20130101) A61K 47/61 (20170801) Original (OR) Class A61K 47/6903 (20170801) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/52 (20130101) A61L 27/54 (20130101) A61L 2300/406 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 70/10 (20200101) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133909 | Boye et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| ASSIGNEE(S) | University of Florida Research Foundation, Incorporated (Gainesville, Florida) |
| INVENTOR(S) | Shannon E. Boye (Gainesville, Florida); Sanford L. Boye (Gainesville, Florida) |
| ABSTRACT | The disclosure provides rAAV particles comprising a new capsid variant, AAV44.9(E531D). The disclosure also provides rAAV particles comprising AAV44.9(E531D) for treatment of the eye, including treatment of retinal disorders. In particular embodiments, the disclosure provides rAAV particles comprising an AAV44.9(E531D) capsid that exhibits enhanced lateral spread after subretinal injection to a fovea of the subject, wherein detachment of the fovea is minimized. The disclosure further provides rAAV particles comprising an AAV44.9(E531D) capsid and a polynucleotide encoding a heterologous nucleic acid sequence. Methods of treatment comprising administering rAAV particles to a mammal in need thereof, and methods of transducing photoreceptor and RPE cells with rAAV particles, are also provided. |
| FILED | Thursday, January 23, 2020 |
| APPL NO | 17/425292 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) Original (OR) Class A61K 48/0075 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 2750/14122 (20130101) C12N 2750/14143 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133910 | Hu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yang Hu (Palo Alto, California) |
| ABSTRACT | Compositions and methods for treating a mammalian subject for an optic nerve (ON) neuropathy and/or reducing or ameliorating degeneration of axons and/or soma of RGCs are provided. Aspects of the composition include a mammalian viral vector, comprising a murine g-synuclein promoter, or functional fragment thereof, that promotes expression of a transgene specifically in retinal ganglion cells (RGCs), said promoter in operable linkage with an expression cassette encoding the transgene, wherein the expressed transgene inhibits activity of an expression product of an endogenous pro-neurodegenerative gene involved in an ER stress and/or UPR pathway that leads to axon or soma degeneration in the RGCs. Aspects of the methods include intravitreally administering the composition to treat the subject for the ON neuropathy. A variety of ON neuropathies may be treated by practicing the methods, including retinal ganglion cell degeneration, glaucoma, optic neuritis, ON traumatic injury and other ON-related diseases. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 17/432794 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0048 (20130101) A61K 31/7105 (20130101) A61K 35/76 (20130101) A61K 38/465 (20130101) A61K 48/0058 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133916 | Hooker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jacob Hooker (Belmont, Massachusetts); Changning Wang (Melrose, Massachusetts); Martin Georg Strebl-Bantillo (Somerville, Massachusetts); Johanna Kaarina Rokka (Boston, Massachusetts) |
| ABSTRACT | Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/455170 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/04 (20130101) Original (OR) Class General Methods of Organic Chemistry; Apparatus Therefor C07B 2200/05 (20130101) Acyclic or Carbocyclic Compounds C07C 259/10 (20130101) C07C 2602/42 (20170501) C07C 2603/74 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220134051 | Boes |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aaron Boes (Iowa City, Iowa) |
| ABSTRACT | A multimodal sensory device for promoting sleep in a subject, including a first sensory delivery component, a second sensory delivery component, and a controller module. The sensory device wherein the first and second sensory delivery components are constructed and arranged for delivering a first and second sensory stimuli to the subject and the controller is constructed and arranged to deliver the first and second sensory stimuli at a synchronized frequency. A method for promoting sleep in a subject including delivering to the subject at least one sensory stimuli at a frequency of between about 1 and 60 hz. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518301 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/291 (20210101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 21/02 (20130101) Original (OR) Class A61M 2021/0044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220134337 | Aksimentiev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Aleksei Aksimentiev (Urbana, Illinois) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane, wherein the membrane has a first side and a second side, wherein the membrane has a first pore disposed therein, wherein the first pore extends through the membrane from the first side of the membrane to the second side of the membrane, wherein the membrane has a second pore disposed therein, and wherein the second pore extends through the membrane from the first side of the membrane to the second side of the membrane; a first channel disposed on the first side of the membrane, wherein the first channel is along a first longitudinal axis; a second channel disposed on the first side of the membrane, wherein the second channel is along a second longitudinal axis, and wherein the first channel and the second channel are disposed side by side adjacent to each other; a third channel disposed on the second side of the membrane, wherein the third channel is along a third longitudinal axis, wherein the third channel is in first fluid communication with the first channel via the first pore, and wherein the third channel is in second fluid communication with the second channel via the second pore; and one or more sensors disposed at one or more locations to facilitate sequencing of a molecule that extends from the first channel, through the first pore across at least a portion of the third channel, and through the second pore into the second channel. Additional embodiments are disclosed. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513516 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0663 (20130101) B01L 2300/0896 (20130101) B01L 2400/0415 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135518 | Lim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | AmberGen, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark J. Lim (Reading, Massachusetts); Gargey Yagnik (Hopkinton, Massachusetts); Kenneth J. Rothschild (Newton, Massachusetts) |
| ABSTRACT | The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme). |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399461 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 271/20 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135529 | Ray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sangeeta Ray (Ellicott City, Maryland); Martin G. Pomper (Baltimore, Maryland); Thomas J. Meade (Wilmette, Illinois); Ronnie C. Mease (Fairfax, Virginia); Ying Chen (Timmonium, Maryland); Xing Yang (Baltimore, Maryland); Matthew Rotz (Carlsbad, California) |
| ABSTRACT | Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific T1-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/575235 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/0002 (20130101) A61K 49/12 (20130101) A61K 49/106 (20130101) A61K 49/108 (20130101) A61K 51/06 (20130101) A61K 51/0402 (20130101) A61K 51/0482 (20130101) A61K 51/0497 (20130101) Heterocyclic Compounds C07D 257/02 (20130101) Original (OR) Class C07D 403/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135556 | Remiszewski et al. |
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| FUNDED BY |
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| APPLICANT(S) | Evrys Bio, LLC (Doylestown, Pennsylvania) |
| ASSIGNEE(S) | Evrys Bio, LLC (Doylestown, Pennsylvania) |
| INVENTOR(S) | Stacy Remiszewski (Doylestown, Pennsylvania); Emre Koyuncu (Doylestown, Pennsylvania); Qun Sun (Princeton, New Jersey); Lillian Chiang (Princeton, New Jersey) |
| ABSTRACT | Novel compounds useful for treating and/or preventing HCMV infections are provided. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/574884 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/427 (20130101) A61K 31/436 (20130101) A61K 31/498 (20130101) A61K 31/506 (20130101) A61K 31/4709 (20130101) A61K 31/4725 (20130101) A61K 31/5377 (20130101) A61K 45/06 (20130101) Heterocyclic Compounds C07D 417/04 (20130101) C07D 417/06 (20130101) C07D 417/10 (20130101) C07D 417/14 (20130101) Original (OR) Class C07D 491/052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135625 | Baric et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ralph Baric (Haw River, North Carolina); Harold Kenneth Dinnon, III (Chapel Hill, North Carolina); Sarah Rebecca Leist (Carrboro, North Carolina); Yixuan Hou (Chapel Hill, North Carolina) |
| ABSTRACT | This invention relates to SARS-CoV-2 viruses adapted with nanoluciferase reporter molecules and mouse-adapted SARS-CoV-2 viruses, compositions including the same and methods of use thereof. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556413 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 2039/53 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/005 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135633 | COHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Tufts Medical Center (Boston, Massachusetts); Trustees of Tufts College (Medford, Massachusetts); On Target Therapeutics LLC (Wellesley, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Charles COHEN (Weston, Massachusetts); Krishna KUMAR (Cambridge, Massachusetts); Jamie Raudensky DOYLE (Newton, Massachusetts); Alan S. KOPIN (Wellesley, Massachusetts) |
| ABSTRACT | The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/525169 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 47/543 (20170801) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 14/4703 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/92 (20130101) G01N 33/5023 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135634 | QU et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Zhaoxia QU (Pittsburgh, Pennsylvania); Gutian XIAO (Pittsburg, Pennsylvania) |
| ABSTRACT | The present disclosure provides methods and compositions for treating cancer (e.g., lung cancer) in a subject by increasing the expression of PDZ-LIM domain containing protein 2 (PDLIM2) in the subject, or a functional fragment thereof. The present disclosure further provides methods of using PDLIM2 as a marker for determining and monitoring a subject's responsiveness to an anti-cancer treatment, providing a prognosis about a cancer in a subject, and selecting an effective anti-cancer treatment for a subject. The present disclosure also provides in vitro methods of screening anti-cancer agents by assessing whether the expression of PDLIM2 is restored by an anti-cancer agent in a cancer cell. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576112 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/4703 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 16/2827 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135643 | Hagood et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Hagood (Chapel Hill, North Carolina); Simon Wong (La Jolla, California) |
| ABSTRACT | The invention relates to a soluble Thy-1 polypeptide or a functional fragment thereof and pharmaceutical compositions including the soluble Thy-1 polypeptide or a functional fragment thereof. The invention also relates to the use of the soluble Thy-1 polypeptide or a functional fragment thereof for delivery to subjects with tissue fibrosis for treating, inhibiting, and/or reversing tissue fibrosis in the subject. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514954 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) Peptides C07K 14/70503 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135655 | Marasco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne A. Marasco (Wellesley, Massachusetts); Yuval Avnir (Boston, Massachusetts) |
| ABSTRACT | The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/385465 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6841 (20170801) Peptides C07K 16/1018 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) C07K 2317/622 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5052 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135661 | LUK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelvin C. LUK (Philadelphia, Pennsylvania); Virginia M.Y. LEE (Philadelphia, Pennsylvania); John Q. TROJANOWSKI (Philadelphia, Pennsylvania); Kurt R. BRUNDEN (Media, Pennsylvania); Dustin COVELL (Philadelphia, Pennsylvania) |
| ABSTRACT | The present disclosure provides monoclonal antibodies that bind α-Synuclein. In certain aspects, the antibodies preferentially bind to α-Synuclein fibrils over α-Synuclein monomer. In other aspects, the invention comprises a method of treating α-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting α-Synuclein fibrils using any of the antibodies of the invention. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/572309 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0029 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/577 (20130101) G01N 33/6896 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135678 | Chaudhary |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Southern California (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Preet M. Chaudhary (Toluca Lake, California) |
| ABSTRACT | Described herein are novel compositions and methods to improve the safety and efficacy of adoptive cellular therapies of cancer, infection, allergic, degenerative and immune disorders. The disclosure provides a) novel methods and compositions to reduce the accidental insertion of chimeric receptors into cancer cells; b) novel methods to measure the titer of viral vectors; c) novel compositions to generate antigen masking receptors and methods to use such receptors to protect normal cells from immunotherapeutic agents; d) novel compositions and methods to extend the life-span of allogeneic cells, including allogeneic CAR-T cells; e) novel compositions and methods to ameliorate the side-effects of cellular therapies and f) novel compositions of Synthetic Immune Receptors and Ab-TCRs with mutant TCRα constant chains. |
| FILED | Saturday, January 18, 2020 |
| APPL NO | 17/423894 |
| CURRENT CPC | Peptides C07K 16/2809 (20130101) Original (OR) Class C07K 16/2863 (20130101) C07K 16/2875 (20130101) C07K 16/2878 (20130101) C07K 16/2887 (20130101) C07K 16/2893 (20130101) C07K 16/3007 (20130101) C07K 2317/31 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135692 | LEE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Bristol (Bristol, United Kingdom); The Government of the U.S.A., as represented by the Secretary of the Department of Health and Human (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard LEE (Bristol, United Kingdom); Andrew DICK (Bristol, United Kingdom); Lauren SCHEWITZ BOWERS (Bristol, United Kingdom); Robert NUSSENBLATT (Bethesda, Maryland); Igal GERY (Bethesda, Maryland); Lai WEI (Bethesda, Maryland) |
| ABSTRACT | The present invention relates to a conjugate that specifically targets a calcineurin inhibitor to T cells, such as Th17 cells, for use in a method for the treatment of an inflammatory disease. The invention also relates to a method for treating an inflammatory disease by administering a conjugate that specifically targets a calcineurin inhibitor to T cells, such as Th17 cells. In addition, the invention relates to a method for identifying a subject likely to be resistant to steroid treatment, as well as a subject likely to benefit from treatment with a calcineurin inhibitor. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/534909 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6803 (20170801) A61K 47/6811 (20170801) A61K 47/6849 (20170801) Peptides C07K 16/2866 (20130101) Original (OR) Class C07K 2317/55 (20130101) C07K 2317/77 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6869 (20130101) G01N 33/6872 (20130101) G01N 2333/7158 (20130101) G01N 2800/52 (20130101) G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135698 | Ho et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ImaginAb, Inc. (Inglewood, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David T. Ho (Long Beach, California); Tove Olafsen (Reseda, California); Arye Lipman (El Segundo, California) |
| ABSTRACT | In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA, an artificial hinge sequence, and a human IgG CH3 sequence. In another embodiment, a CysDB monomer that binds PSMA is provided. The CysDB monomer may be encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA and a cysteine tail. In other embodiments, methods for diagnosing or treating a cancer associated with PSMA expression in a subject are provided. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/455097 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/1072 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/3069 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/56 (20130101) C07K 2317/64 (20130101) C07K 2317/77 (20130101) C07K 2317/90 (20130101) C07K 2317/526 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135704 | Tsimikas et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sotirios Tsimikas (San Diego, California); Joseph Witztum (San Diego, California); Xuchu Que (San Diego, California) |
| ABSTRACT | The disclosure provides for single chain variable fragments to MAA-oxidized specific epitopes (OSEs). The disclosure also provides single chain variable fragments that bind to MDA-OSEs or MAA-OSEs on oxidized phospholipids and methods of use thereof, including the production of transgenic animal models and the use of the fragments as therapeutic agents. |
| FILED | Wednesday, October 13, 2021 |
| APPL NO | 17/500794 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 9/10 (20180101) Peptides C07K 16/44 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) G01N 2800/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135925 | Reiserer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); Gregory B. Gerken (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578966 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/08 (20130101) C12M 23/10 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/50 (20130101) C12M 23/58 (20130101) C12M 27/02 (20130101) C12M 27/12 (20130101) C12M 29/10 (20130101) Original (OR) Class C12M 35/02 (20130101) C12M 35/04 (20130101) C12M 41/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135951 | Czirok et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andras Czirok (Roeland Park, Kansas); Pamela Tran (Overland Park, Kansas) |
| ABSTRACT | A renal tube assay device can include: a container having an inlet port and an outlet port; a matrix material in the container; and a lumen in the matrix material extending from the inlet port to the outlet port. The lumen can include a luminal surface with at least one low density region that has a lower density compared to another adjacent region of the matrix material that is located at least partially around the at least one low density region. The low density region can have a form of a bubble, bulge, capsule, or the like. The low density region can bulge into the lumen. A port can be adapted for receiving a pipette tip. The matrix material can include a hydrogel. The container can be located in a cell culture dish. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518395 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/06 (20130101) C12M 23/16 (20130101) C12M 41/36 (20130101) C12M 41/46 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0686 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5044 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135961 | Agar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brandeis University (Waltham, Massachusetts) |
| ASSIGNEE(S) | Brandeis University (Waltham, Massachusetts) |
| INVENTOR(S) | Jeffrey N. Agar (Newton, Massachusetts); Joseph Salisbury (Cranston, Rhode Island) |
| ABSTRACT | Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/574742 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/095 (20130101) A61K 31/385 (20130101) Peptides C07K 19/00 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0089 (20130101) C12N 9/96 (20130101) Original (OR) Class Enzymes C12Y 115/01001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135967 | Buckley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Dennis Buckley (Jamaica Plain, Massachusetts); Georg Winter (Vienna, Austria); Andrew J. Phillips (Arlington, Massachusetts); Timothy Heffernan (Sugar Land, Texas); James Bradner (Weston, Massachusetts); Justin Roberts (Cambridge, Massachusetts); Behnam Nabet (Boston, Massachusetts) |
| ABSTRACT | The present invention provides a means to modulate gene expression in vivo in a manner that avoids problems associated with CRISPR endogenous protein knock-out or knock-in strategies and strategies that provide for correction, or alteration, of single nucleotides. The invention includes inserting into the genome a nucleotide encoding a heterobifunctional compound targeting protein (dTAG) in-frame with the nucleotide sequence of a gene encoding an endogenously expressed protein of interest which, upon expression, produces an endogenous protein-dTAG hybrid protein. This allows for targeted protein degradation of the dTAG and the fused endogenous protein using a heterobifunctional compound. |
| FILED | Thursday, January 20, 2022 |
| APPL NO | 17/580190 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/58 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) A61K 31/551 (20130101) A61K 31/575 (20130101) A61K 31/4525 (20130101) A61K 31/4545 (20130101) A61K 31/4985 (20130101) A61K 31/5513 (20130101) A61K 35/17 (20130101) A61K 2035/122 (20130101) Peptides C07K 14/47 (20130101) C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 16/00 (20130101) C07K 16/2863 (20130101) C07K 2317/622 (20130101) C07K 2319/03 (20130101) C07K 2319/20 (20130101) C07K 2319/95 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/11 (20130101) Original (OR) Class C12N 15/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135971 | Tran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Tran (Gainesville, Florida); Son Bang Le (Gainesville, Florida) |
| ABSTRACT | Provided methods of inhibiting a glioblastoma stem-like cell (GSC), methods of treating a subject with glioblastoma, and methods of reprogramming an astrocyte to a glioblastoma stem-like cell (GSC). |
| FILED | Thursday, February 06, 2020 |
| APPL NO | 17/428722 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/86 (20130101) C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/122 (20130101) C12N 2310/531 (20130101) C12N 2320/32 (20130101) C12N 2740/15043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135973 | GREENBERG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas); Oregon State University (Corvallis, Oregon) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas); Oregon State University (Corvallis, Oregon) |
| INVENTOR(S) | David GREENBERG (Coppell, Texas); Bruce L. GELLER (Corvallis, Oregon) |
| ABSTRACT | Provided are antisense oligomers targeted against bacterial mRNAs and other macromolecules associated with a biochemical pathway and/or cellular process, and related compositions and methods of using the oligomers and compositions to treat an infected mammalian subject, for example, as primary antimicrobials or as adjunctive therapies with classic antimicrobials. |
| FILED | Tuesday, October 12, 2021 |
| APPL NO | 17/498880 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/712 (20130101) A61K 31/7115 (20130101) A61K 47/42 (20130101) A61K 47/66 (20170801) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/3233 (20130101) C12N 2310/3513 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135975 | SINGH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER (Fort Worth, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | MEHARVAN SINGH (BENBROOK, Texas); CHANG SU (LUCAS, Texas); TRINH NGUYEN (HUMBLE, Texas) |
| ABSTRACT | The subject invention provides methods of treating neurological disease or disorder, such as brain injuries, such as stroke, traumatic brain injury (TBI), or other ischemic events that cause brain injury by inhibiting or down-regulating Let-7i activity or function. The disclosed methods may have the potential to extend the “window of opportunity” for treatment of such injuries and enhance the effectiveness of existing therapeutics. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/580689 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 38/185 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/11 (20130101) C12N 2310/141 (20130101) C12N 2320/31 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135982 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan Kettering Cancer Center (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chichao CHEN (New York, New York); Scott LOWE (New York, New York) |
| ABSTRACT | The present disclosure relates generally to compositions and methods for treating or ameliorating acute myeloid leukemia in a subject in need thereof. In particular, the present disclosure provides a method comprising administering to a subject a therapeutically effective amount of at least one agent that suppresses Trim28 activity. |
| FILED | Thursday, February 06, 2020 |
| APPL NO | 17/428322 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/104 (20130101) C12N 15/1137 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2320/12 (20130101) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135985 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Rockefeller University (New York, New York) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); David Benjamin Turitz Cox (Cambridge, Massachusetts); Luciano Marraffini (New York, New York); David Olivier Bikard (Paris, France); Wenyan Jiang (Whitestone, New York); Neville Espi Sanjana (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system. |
| FILED | Monday, October 18, 2021 |
| APPL NO | 17/503928 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/70 (20130101) C12N 15/74 (20130101) C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/113 (20130101) C12N 15/746 (20130101) Original (OR) Class C12N 15/907 (20130101) C12N 15/1082 (20130101) C12N 15/8509 (20130101) C12N 2310/20 (20170501) C12N 2310/531 (20130101) C12N 2310/3519 (20130101) C12N 2800/101 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136002 | Shultz |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| ASSIGNEE(S) | The Jackson Laboratory (Bar Harbor, Maine) |
| INVENTOR(S) | Leonard D. Shultz (Bar Harbor, Maine) |
| ABSTRACT | Provided herein, in some aspects, is a NOD.Cg-Prkdcscid Il2rgtm1wjl/SzJ (NOD scid gamma or NSG™) mouse comprising a nucleic acid encoding human FLT3L and an inactivated mouse Flt3 allele, methods of producing the mouse, and methods of using the mouse. |
| FILED | Thursday, February 13, 2020 |
| APPL NO | 17/430364 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 67/0275 (20130101) A01K 2217/05 (20130101) A01K 2227/105 (20130101) A01K 2267/03 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 15/8509 (20130101) Original (OR) Class C12N 2517/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136004 | May et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Chan Zuckerberg Biohub, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew P May (San Francisco, California); Eleonore Tham (San Francisco, California); Lucy Maynard (San Francisco, California); Marco Mignardi (San Francisco, California); Nicole K. Paulk (San Francisco, California); Ryan T. Leenay (San Francisco, California); Gagandeep Renuka Kumar (San Francisco, California) |
| ABSTRACT | An in vivo method of modifying a genome of a target cell in a mammalian subject is described. The method includes administering an effective amount of a transducer cell to the subject, where the transducer cell includes a regulated viral vector delivery system (RVVDS) for producing and releasing viral transduction particles (VTPs) when the transducer cell is exposed to inducing conditions, and each VTP comprises a nucleic acid encoding a genome modification system (GMS) comprising a genome modification protein and one or more elements that regulate expression or activity of the genome modification protein in a mammalian cell. |
| FILED | Monday, January 13, 2020 |
| APPL NO | 17/422173 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/65 (20130101) A61K 35/15 (20130101) A61K 48/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2310/20 (20170501) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) C12N 2800/80 (20130101) C12N 2830/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136010 | Samulski |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard Jude Samulski (Hillsborough, North Carolina) |
| ABSTRACT | Disclosed herein are methods and compositions comprising an adeno-associated virus 2.5 (AAV2.5) capsid protein, comprising one or more amino acids substitutions, (e.g., which does not contain a substitution at the position corresponding to amino acid 267 of AAV2.5, or does not contain a serine at the position corresponding to amino acid 267 of AAV2.5) wherein the substitutions introduce a new glycan binding site into the AAV capsid protein. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581639 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) A61P 31/18 (20180101) A61P 31/20 (20180101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14122 (20130101) C12N 2750/14142 (20130101) C12N 2750/14143 (20130101) C12N 2750/14171 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136019 | Baker et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of South Florida (Tampa, Florida); INSTITUTO POLITÉCNICO NACIONAL (MEXICO CITY, Mexico); KING ABDULAZIZ UNIVERSITY (JEDDAH, Saudi Arabia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bill J. Baker (Temple Terrace, Florida); Dennis E. Kyle (Athens, Georgia); Mario Alberto Rodriguez-Pérez (Reynosa, Mexico); Anne-Claire D. Limon (Tampa, Florida); Ala Azhari (Tampa, Florida) |
| ABSTRACT | Described herein are methods of epigenetic modification of fungi and uses thereof. Also described herein are compounds that can have antileishmanial activity and formulations thereof. Also described herein are methods of treating leishmanial infection in a subject that include the step of administering a compound or formulation thereof described herein to the subject. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/406025 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/366 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 33/02 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/14 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/181 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136051 | Fan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| ASSIGNEE(S) | St. Jude Children's Research Hospital (Memphis, Tennessee) |
| INVENTOR(S) | Yiping Fan (Memphis, Tennessee); Jeremy Crawford (Memphis, Tennessee); Benjamin Youngblood (Memphis, Tennessee) |
| ABSTRACT | Provided herein are methods and compositions for determining T-cell differentiation by comparing the methylation status of T cells relative to a T cell methylation index and using this determination to identify or isolate populations of T cells having desired T cell multipotency. Further, the present methods and compositions can be used to monitor or treat symptoms of chronic infections, autoimmune diseases, and cancer. |
| FILED | Monday, February 24, 2020 |
| APPL NO | 17/432721 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6881 (20130101) Original (OR) Class C12Q 2600/154 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136059 | Czyzyk-Krzeska et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Maria Franciszka Czyzyk-Krzeska (Cincinnati, Ohio); Julio Alberto Landero Figueroa (Cincinnati, Ohio); Jarek Meller (Cincinnati, Ohio); David Plas (Cincinnati, Ohio); Shuchi Gulati (Cincinnati, Ohio); Bhargav Vemuri (Mason, Ohio); John Thomas Cunningham, IV (Maineville, Ohio) |
| ABSTRACT | A method of diagnosing the likelihood of recurrence of clear cell renal cell carcinoma is provided. The method involves a) detecting the gene expression signatures of mitochondrial electron transport chain subunits, mitochondrial ribosomal proteins, major histocompatibility complex class II (MHC-II) proteins or combinations thereof in a kidney tumor tissue sample; and b) determining that the subject has an elevated risk of recurrence of clear cell renal cell carcinoma if the gene expression signatures include certain sequences. In another embodiment, the method uses copper levels to diagnose the likelihood of recurrence of clear cell renal cell carcinoma. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/327100 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) G01N 2333/90216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136068 | SMITH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, A Body Corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clayton SMITH (Aurora, Colorado); Craig T. JORDAN (Aurora, Colorado); Daniel POLLYEA (Aurora, Colorado); Shanshan PEI (Aurora, Colorado) |
| ABSTRACT | The present disclosure relates to methods of identifying AML patients who will be resistant to venetoclax therapy and methods of treating venetoclax-resistant patients with myeloid leukemia cell differentiation protein (MCL-1) inhibitors. |
| FILED | Friday, March 06, 2020 |
| APPL NO | 17/435728 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/706 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136949 | Kimmerling et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Robert J. Kimmerling (Cambridge, Massachusetts); Nicholas L. Calistri (New Fairfield, Connecticut); Scott R. Manalis (Portland, Oregon); Selim Olcum (Cambridge, Massachusetts); Mark M. Stevens (Seattle, Washington) |
| ABSTRACT | Systems and methods for flowing particles, such as biological entities, in a fluidic channel(s) are generally provided. In some cases, the systems described herein are designed such that a single particle may be isolated from a plurality of particles and flowed into a fluidic channel (e.g., a microfluidic channel) and/or collected e.g., on fluidically isolated surfaces. For example, the single particle may be present in a plurality of particles of relatively high density and the single particle is flowed into a fluidic channel, such that it is separated from the plurality of particles. The particles may be spaced within a fluidic channel so that individual particles may be measured/observed over time. In certain embodiments, the particle may be a biological entity. Such article and methods may be useful, for example, for isolating single cells into individual wells of multi-well cell culture dishes (e.g., for single-cell analysis). |
| FILED | Thursday, October 07, 2021 |
| APPL NO | 17/496096 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502746 (20130101) B01L 3/502753 (20130101) B01L 3/502761 (20130101) B01L 2300/0663 (20130101) B01L 2300/0864 (20130101) B01L 2400/0415 (20130101) B01L 2400/0487 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/0205 (20130101) G01N 15/0255 (20130101) Original (OR) Class G01N 15/0618 (20130101) G01N 15/1056 (20130101) G01N 15/1484 (20130101) G01N 2015/149 (20130101) G01N 2015/0288 (20130101) G01N 2015/1006 (20130101) G01N 2015/1081 (20130101) G01N 2015/1087 (20130101) G01N 2015/1493 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136972 | LEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ki-Bum LEE (Monmouth Junction, New Jersey); Letao YANG (Edison, New Jersey) |
| ABSTRACT | A surface-enhanced Raman scattering (SERS) sensing system or platform and methods of using the same, where the platform comprises a graphene coated-homogeneous plasmonic metal hybrid array, which synergizes both electromagnetic mechanism (EM)- and chemical mechanism (CM)-based signal enhancement for achieving sensitive and reproducible detection of Raman signals. The system and methods of using such system or platform may be applied to the analyses of various bio/chemical molecules, such as but not limited to those found in cells, in a highly sensitive and selective manner. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512211 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) Original (OR) Class G01N 33/54306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136973 | Rodriguez et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebeca S. Rodriguez (St. Paul, Minnesota); Victoria M. Szlag (St. Paul, Minnesota); Theresa M. Reineke (Vadnais Heights, Minnesota); Christy L. Haynes (Minneapolis, Minnesota) |
| ABSTRACT | Methods and systems related to a linear polymer affinity agent sensor for SERS are disclosed. Use of the sensor may include mixing a linear polymer affinity agent in a sample solution, subjecting a metal substrate to the sample solution to attach the linear polymer affinity agent to the metal substrate, generating, via Raman Spectroscopy, spectral data representing the at least one linear polymer affinity agent attached to the metal substrate, and determining whether two or more analytes are present in the solution at respective minimum threshold concentrations based on the spectral data. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514016 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) Original (OR) Class G01N 33/553 (20130101) G01N 33/54373 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136999 | Garimella et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Venkata BS Garimella (Richland, Washington); Ahmed M. Hamid (Richland, Washington); Yehia M. Ibrahim (West Richland, Washington); Richard D. Smith (Richland, None) |
| ABSTRACT | Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557690 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/624 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/26 (20130101) H01J 49/0027 (20130101) H01J 49/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137026 | Bass et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph T. Bass (Winnetka, Illinois); Clara Bien Peek (Chicago, Illinois); Akihiko Taguchi (Chicago, Illinois); Mark Perelis (Evanston, Illinois); Biliana Marcheva (Evanston, Illinois) |
| ABSTRACT | The present invention relates to cells with altered cell cycle control. In particular, the present invention provides cells with altered cell cycle control and uses of such cells to identify metabolically active agents. |
| FILED | Thursday, January 13, 2022 |
| APPL NO | 17/574695 |
| CURRENT CPC | Peptides C07K 14/4702 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0658 (20130101) C12N 5/0676 (20130101) C12N 2510/00 (20130101) C12N 2510/04 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6897 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/507 (20130101) Original (OR) Class G01N 33/5005 (20130101) G01N 33/5008 (20130101) G01N 33/5061 (20130101) G01N 2333/62 (20130101) G01N 2800/042 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137053 | Chilton et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Floyd Chilton (Tucson, Arizona); Ashley Jones Snider (Tucson, Arizona); Justin Michael Snider (Tucson, Arizona) |
| ABSTRACT | Provided herein are biomarkers for cancer screening and monitoring. In particular, provided herein are lipid biomarkers for cancer diagnosis, prognosis, risk, and response to treatment. |
| FILED | Wednesday, January 29, 2020 |
| APPL NO | 17/310274 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5743 (20130101) G01N 33/57423 (20130101) G01N 33/57434 (20130101) Original (OR) Class G01N 33/57442 (20130101) G01N 33/57446 (20130101) G01N 33/57449 (20130101) G01N 2405/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137063 | Regnier et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Novilytic, LLC (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Fred Regnier (West Lafayette, Indiana); Jinhee Kim (West Lafayette, Indiana); Meena Narsimhan (West Lafayette, Indiana); Paul Dreier (West Lafayette, Indiana) |
| ABSTRACT | A system and method is provided for validating the manufacturing process for the production of complex biological compositions, and particularly for providing process validation information for evaluation by a federal regulatory agency. The system and method continuously and chronologically assess the concentration of proteoforms within the biological composition as it is being produced in a fermentor. Samples from the fermentor are analyzed in a pre-selected array of analysis columns, with data generated by the columns being accumulated and evaluated, and particularly compared with data from previous stages in the production process. A continuous process validation system includes top-down and bottom-up analysis sectors, each including a plurality of different analysis columns that can be selected by the controller for a particular biological composition and a particular production process. |
| FILED | Thursday, September 16, 2021 |
| APPL NO | 17/476810 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 30/14 (20130101) G01N 30/72 (20130101) G01N 33/6845 (20130101) G01N 33/6848 (20130101) Original (OR) Class G01N 2021/6432 (20130101) G01N 2030/027 (20130101) G01N 2560/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137064 | Lim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AmberGen, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark J. Lim (Reading, Massachusetts); Gargey Yagnik (Hopkinton, Massachusetts); Kenneth J. Rothschild (Newton, Massachusetts) |
| ABSTRACT | The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme). |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399390 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137065 | Lim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AmberGen, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark J. Lim (Reading, Massachusetts); Gargey Yagnik (Hopkinton, Massachusetts); Kenneth J. Rothschild (Newton, Massachusetts) |
| ABSTRACT | The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme). |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399417 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6841 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137066 | Lim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AmberGen, Inc. (Watertown, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark J. Lim (Reading, Massachusetts); Gargey Yagnik (Hopkinton, Massachusetts); Kenneth J. Rothschild (Newton, Massachusetts) |
| ABSTRACT | The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands. Finally, the field of the invention also encompasses multi-omic MSI procedures, where MSI of photocleavable mass-tag probes is combined with other modes of MSI, such as direct label-free MSI of endogenous biomolecules from the biospecimen (e.g., tissue), whereby said biomolecules can be intact or digested (e.g., chemically digested or by enzyme). |
| FILED | Wednesday, August 11, 2021 |
| APPL NO | 17/399434 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6851 (20130101) Original (OR) Class G01N 2400/00 (20130101) G01N 2458/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138939 | Jalali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Bahram Jalali (Oakland, California); Madhuri Suthar (Oakland, California); Cejo Konuparamban Lonappan (Oakland, California); Antoni Ribas (Oakland, California); Theodore Scott Nowicki (Oakland, California); Jia Ming Chen (Oakland, California) |
| ABSTRACT | Systems and methods for digital pathology in accordance with embodiments of the invention obtain a whole slide image of a microscope slide that includes a registration mark, wherein the registration mark is associated with a coordinate system. The method inputs the whole slide image into a region identification (RI) model to extract features of the whole slide image and generate feature vectors for the extracted features, detects a presence of a region of interest (ROI) based on the feature vectors, determines a set of coordinates of the ROI in the coordinate system, and translates a microscope stage of a microscope holding the microscope slide to a position corresponding to the coordinates of the ROI. The method captures a field of view (FOV) image with the microscope and inputs the FOV image into a grading model to determine a pathology score that indicates a likelihood of a presence of a disease. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/431138 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/365 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/40 (20220101) G06V 20/693 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 30/40 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220139497 | Kurtz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| INVENTOR(S) | David M. Kurtz (San Francisco, California); Maximilian Diehn (San Carlos, California); Arash Ash Alizadeh (San Mateo, California) |
| ABSTRACT | Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/455209 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1089 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) G16B 35/20 (20190201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220132839 | Riffell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Jeffrey A. Riffell (Seattle, Washington); Chloé Lahondère (Seattle, Washington); Clément Vinauger (Seattle, Washington) |
| ABSTRACT | Mosquito attractant composition for attracting a mosquito to a pre-determined location. The composition includes a combination of nonanal and lilac aldehydes. |
| FILED | Thursday, February 20, 2020 |
| APPL NO | 17/431869 |
| CURRENT CPC | Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants A01M 1/2016 (20130101) A01M 29/12 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 31/02 (20130101) Original (OR) Class A01N 31/04 (20130101) A01N 43/08 (20130101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 17/00 (20210801) A01P 19/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220132971 | Matsushita et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Albert Keisuke Matsushita (La Jolla, California); Luis Garcia (San Diego, California); Skye Edwards (San Diego, California); Michael Collins (San Diego, California); Charles Zahl (San Diego, California) |
| ABSTRACT | A jammer system includes a jammer unit, a valve coupled to the jammer unit, and a sensor coupled to the valve. The jammer unit includes a jammer media and a membrane including an inlet. The membrane is configured to surround the jammer media. The valve is configured to allow a fluid to pass through the inlet of the membrane. The sensor is configured to cause actuation of the valve to evacuate the fluid from an interior of the membrane. The evacuation of the fluid from the interior of the membrane results in stiffening of the jammer media within the membrane. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516524 |
| CURRENT CPC | Hats; Head Coverings A42B 3/046 (20130101) Original (OR) Class A42B 3/0453 (20130101) A42B 3/0486 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133639 | Thayumanavan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sankaran Thayumanavan (Amherst, Massachusetts); Jiaming Zhuang (Amherst, Massachusetts); Hui Wang (Sunderland, Massachusetts) |
| ABSTRACT | The invention generally relates to polymer-based nano-structures. More particularly, the invention relates to novel, surface-functionalized, guest-host polymer nano-assemblies and nano-delivery vehicles useful in diverse fields including drug delivery, diagnostics and specialty materials. The nano-assemblies and nano-delivery vehicles of the invention are afforded via simplify and reliable approaches. |
| FILED | Saturday, July 31, 2021 |
| APPL NO | 17/390912 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5138 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 47/6903 (20170801) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133730 | Zuo et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| ASSIGNEE(S) | Ting Therapeutics LLC (Omaha, Nebraska) |
| INVENTOR(S) | Jian Zuo (Omaha, Nebraska); Tal Teitz (Omaha, Nebraska) |
| ABSTRACT | Method, kit and pharmaceutical compositions using an inhibitor of EGFR signaling for prevention or treatment of hearing loss are described. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/580755 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/506 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/4439 (20130101) A61K 31/4709 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 27/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133743 | Mustoe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas A. Mustoe (Evanston, Illinois); Robert D. Galiano (Chicago, Illinois); Seok Jong Hong (Northbrook, Illinois); Ping Xie (Chicago, Illinois); Shengxian Jia (Wilmette, Illinois) |
| ABSTRACT | Provided herein are compositions, systems, and methods for treating wounds with the combination of statins and cholesterol to help prevent and reduce scar formation. |
| FILED | Tuesday, July 13, 2021 |
| APPL NO | 17/374488 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/06 (20130101) A61K 9/0014 (20130101) A61K 9/14 (20130101) A61K 9/107 (20130101) A61K 9/1075 (20130101) A61K 31/22 (20130101) A61K 31/225 (20130101) A61K 31/366 (20130101) A61K 31/575 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/10 (20130101) A61K 47/12 (20130101) A61K 47/14 (20130101) A61K 47/44 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 17/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133793 | LUM et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Provincial Health Services Authority (Vancouver, Canada); UNIVERSITÉ LAVAL (Québec, Canada) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Julian J. LUM (Victoria, Canada); Lindsay DEVORKIN (Burnaby, Canada); Yannick DOYON (Québec, Canada); Gillian CARLETON (Victoria, Canada) |
| ABSTRACT | Lymphocytes having a suppressed autophagy gene useful in immunotherapy are disclosed. The lymphocytes can express an antigen targeting receptor such as a chimeric antigen receptor (CAR) or endogenous or engineered T-cell receptor to target cells expressing a tumor-specific antigen. Methods of making and using such lymphocytes are disclosed. Some such lymphocytes are useful in conducting CAR-T or TCR-T therapy. |
| FILED | Wednesday, February 12, 2020 |
| APPL NO | 17/430055 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/1774 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220134341 | MILLER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sinead E. MILLER (Houston, Texas); Charleson S. BELL (Nashville, Tennessee); Todd D. GIORGIO (Nashville, Tennessee); Andrew L. COOK (Antioch, Tennessee) |
| ABSTRACT | The present disclosure relates to a fluidic device to detect, capture, and/or remove disease material in a biological fluid. The present invention also relates to methods for the treatment/prevention of sepsis through the use of the claimed device. |
| FILED | Wednesday, September 01, 2021 |
| APPL NO | 17/464103 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/12 (20130101) A61K 38/14 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/165 (20130101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) B01L 3/502753 (20130101) Original (OR) Class B01L 3/502776 (20130101) B01L 2300/16 (20130101) B01L 2300/0861 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48 (20130101) G01N 33/53 (20130101) G01N 33/543 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220134429 | PARSONS |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Ethan PARSONS (Cambridge, Massachusetts) |
| ABSTRACT | Compositions and methods of making compositions for additive manufacturing of composite powders including metal ceramic alloyed material is described. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/520134 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/05 (20220101) B22F 9/04 (20130101) Original (OR) Class B22F 10/28 (20210101) B22F 2009/041 (20130101) B22F 2301/052 (20130101) B22F 2304/10 (20130101) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 40/10 (20200101) B33Y 70/10 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220134639 | Allen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vadient Optics, LLC (Beaverton, Oregon) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Leonard Allen (Eugene, Oregon); John Paul Harmon (Albany, Oregon); Samuel Peter Grimm (Philomath, Oregon); George Williams (Vashon, Washington); Peter George Hugger (Eugene, Oregon) |
| ABSTRACT | An additively manufactured article is assembled from a plurality of printed voxels. The article includes a lattice of unit cells of a composite lattice material and an encasing matrix of structural material arranged between adjacent unit cells of the lattice. The structural material has greater mechanical strength than the composite lattice material. |
| FILED | Friday, January 21, 2022 |
| APPL NO | 17/581478 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/112 (20170801) Original (OR) Class B29C 64/209 (20170801) B29C 64/245 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) B33Y 40/20 (20200101) B33Y 50/02 (20141201) B33Y 70/00 (20141201) B33Y 80/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135210 | Fegely et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Bell Textron Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Cody Fegely (Irving, Texas); Kenneth Stephen Wittmer (Sandy Hook, Connecticut) |
| ABSTRACT | There is disclosed in one example a flight control computer for a rotary aircraft, including: a first interface to communicatively couple to a flight control input; a second interface to communicatively couple to flight geometry actuators; a data source; a multi-dimensional lookup table including a data structure to correlate flight control inputs to flight geometry actuator outputs according to a third-factor; and circuitry and logic instructions to: receive an input via the first interface; query the data source for the third-factor; query the multi-dimensional lookup table for a control input modifier according to the flight control input and the third-factor; and compute and send via a third interface a flight geometry output according to the control input modifier. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/083900 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 13/503 (20130101) Original (OR) Class B64C 27/04 (20130101) B64C 2027/8209 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/085 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135237 | Jamison |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Jamison (Luther, Oklahoma) |
| ABSTRACT | Ice detection test apparatuses, systems, and methods are disclosed. In some cases, ice detection and precautionary system shut-down event reduction systems and related methods are provided. The system utilizes a turbine engine ice detection apparatus that includes and engine pressure simulation device, an air moving device, and a first air pressure sensor associated with the engine pressure simulation device. The embodiment further includes an ice monitor controller that receives inputs from the first air pressure sensor and at least one second sensor located adjacent a turbine engine intake. The ice monitor controller performs comparisons of inputs from these sensors against each other and stored values to determine actual icing conditions then generate warnings on a display to an operator. The exemplary control section has multiple modes including manual, semi-manual and automatic. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509214 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 19/00 (20130101) Equipment for Fitting in or to Aircraft; Flying Suits; Parachutes; Arrangements or Mounting of Power Plants or Propulsion Transmissions in Aircraft B64D 15/20 (20130101) Original (OR) Class Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 21/14 (20130101) F01D 25/02 (20130101) Wind Motors F03D 80/40 (20160501) Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 13/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135423 | Hugger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Vadient Optics, LLC (Beaverton, Oregon) |
| ASSIGNEE(S) | Vadient Optics, LLC (Beaverton, Oregon) |
| INVENTOR(S) | Peter G Hugger (Eugene, Oregon); Chad N Teters (Eugene, Oregon); Thomas L Allen (Eugene, Oregon); Ernst Adrian Henle (Eugene, Oregon); Peter J Polesnak (Eugene, Oregon) |
| ABSTRACT | Methods and apparatus for producing a magnetic nanoparticle suitable for additive manufacturing techniques includes providing a solution having a plurality of metallic precursors to produce magnetic nanoparticles, a coordinating solvent, and a chelating agent. The solution is mixed and heated to grow nanoparticles wherein magnetic nanoparticles are formed. The solution is then cooled and a magnetic field is applied to the solution wherein ferrite nanoparticles are at least partially separated by size. |
| FILED | Tuesday, June 23, 2020 |
| APPL NO | 16/909533 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 40/10 (20200101) B33Y 70/00 (20141201) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 49/0063 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2004/64 (20130101) C01P 2006/42 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/037 (20130101) C09D 11/322 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135530 | Piercey et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Davin Glenn Piercey (Lafayette, Indiana); Timothy D. Manship (Zionsville, Indiana); Dawson Michael Smith (Marana, Arizona) |
| ABSTRACT | This disclosure shows the ability of a readily-available oxidizer to achieve oxidation of 5-amino-1H-tetrazole (5-AT) to 5-nitrotetrazole (5-NT) in high yields in a single pot synthesis. This strategy reduces the synthesis of this important energetic material down to a single step and eliminates highly sensitive diazonium and copper salt primary explosive intermediates. The overall yield of this process is 48-53% and the resultant aqueous solution of product effectively used for the preparation of nitrotetrazole-containing primary explosive DBX-1. Unlike current methods of nitrotetrazole preparation, the novel method is entirely solution-based and prepares a final solution of sodium nitrotetrazolate, never once needing to handle energetic intermediates or products, making it a much safer method of nitrotetrazole preparation. |
| FILED | Monday, April 05, 2021 |
| APPL NO | 17/221863 |
| CURRENT CPC | Heterocyclic Compounds C07D 257/06 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135572 | Haystead et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Timothy A. J. Haystead (Chapel Hill, North Carolina); Philip Floyd Hughes (Chapel Hill, North Carolina) |
| ABSTRACT | Described herein are compounds that may selectively bind to Hsp90, methods of using the compounds, and kits including the compounds. The compounds may allow for selective detection of Hsp90 in a sample. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/572222 |
| CURRENT CPC | Heterocyclic Compounds C07D 403/14 (20130101) C07D 487/04 (20130101) Original (OR) Class C07D 491/107 (20130101) C07D 498/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135654 | Goldman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of the Navy (Arlington, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ellen R. Goldman (Germantown, Maryland); George P. Anderson (Bowie, Maryland); Jinny L. Liu (Ellicot City, District of Columbia); Thomas J. Esparza (Frederick, Maryland) |
| ABSTRACT | A number of single domain antibodies (sdAb, also known as nanobodies or VHH) were developed that bind nucleocapsid protein of the SARS-CoV-2 virus. They are useful for detecting the virus and could also find application in therapeutics. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/512837 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 2039/507 (20130101) Peptides C07K 16/10 (20130101) Original (OR) Class C07K 16/468 (20130101) C07K 2317/31 (20130101) C07K 2317/565 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/563 (20130101) G01N 33/56983 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135655 | Marasco et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wayne A. Marasco (Wellesley, Massachusetts); Yuval Avnir (Boston, Massachusetts) |
| ABSTRACT | The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection. |
| FILED | Monday, July 26, 2021 |
| APPL NO | 17/385465 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/6841 (20170801) Peptides C07K 16/1018 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/54 (20130101) C07K 2317/55 (20130101) C07K 2317/56 (20130101) C07K 2317/76 (20130101) C07K 2317/92 (20130101) C07K 2317/565 (20130101) C07K 2317/567 (20130101) C07K 2317/622 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5052 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135892 | PATEL |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nikhil Manubhai PATEL (Grand Forks, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikhil Manubhai PATEL (Grand Forks, North Dakota) |
| ABSTRACT | The present invention discloses a gasifier and/or a gasification process that provides a long, uniform temperature zone in the gasifier, regardless of the particle size, chemical composition, and moisture content of the fuel by sandwiching a reduction zones between two oxidation zones. The gasifier and/or gasification process has a char that is more energy-dense and almost devoid of moisture that affords for an additional (or char) oxidation zone with a temperature that is higher than a first oxidation zone which is closer to an evaporation and devolatilization zone. As such, the additional (or char) oxidation zone contributes to augmenting the reduction zone temperature, thereby providing a favorable dual impact in improving syngas composition and near-complete conversion of the tar. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570448 |
| CURRENT CPC | Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases C10J 3/08 (20130101) Original (OR) Class C10J 3/22 (20130101) C10J 3/26 (20130101) C10J 3/723 (20130101) C10J 2300/092 (20130101) C10J 2300/093 (20130101) C10J 2300/0946 (20130101) C10J 2300/0956 (20130101) C10J 2300/0959 (20130101) C10J 2300/0976 (20130101) C10J 2300/1246 (20130101) Purifying or Modifying the Chemical Composition of Combustible Gases Containing Carbon Monoxide C10K 1/024 (20130101) C10K 1/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136059 | Czyzyk-Krzeska et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Maria Franciszka Czyzyk-Krzeska (Cincinnati, Ohio); Julio Alberto Landero Figueroa (Cincinnati, Ohio); Jarek Meller (Cincinnati, Ohio); David Plas (Cincinnati, Ohio); Shuchi Gulati (Cincinnati, Ohio); Bhargav Vemuri (Mason, Ohio); John Thomas Cunningham, IV (Maineville, Ohio) |
| ABSTRACT | A method of diagnosing the likelihood of recurrence of clear cell renal cell carcinoma is provided. The method involves a) detecting the gene expression signatures of mitochondrial electron transport chain subunits, mitochondrial ribosomal proteins, major histocompatibility complex class II (MHC-II) proteins or combinations thereof in a kidney tumor tissue sample; and b) determining that the subject has an elevated risk of recurrence of clear cell renal cell carcinoma if the gene expression signatures include certain sequences. In another embodiment, the method uses copper levels to diagnose the likelihood of recurrence of clear cell renal cell carcinoma. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/327100 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) G01N 2333/90216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136119 | Flanders et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Opus 12 Incorporated (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas H. Flanders (San Francisco, California); Kendra P. Kuhl (Oakland, California); Etosha R. Cave (Berkeley, California); Sichao Ma (Dublin, California); Ziyang Huo (Moraga, California); Carter S. Haines (Berkeley, California); Timothy A. Bekkedahl (Sunnyvale, California); Kathryn L. Corp (Berkeley, California); Ashley D. Mishra (Danville, California); Edward Izett (Berkeley, California) |
| ABSTRACT | A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/444356 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/08 (20130101) B01J 20/10 (20130101) B01J 20/20 (20130101) B01J 20/3483 (20130101) B01J 2220/42 (20130101) Apparatus for Enzymology or Microbiology; C12M 43/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/023 (20130101) C12P 7/06 (20130101) C12P 7/16 (20130101) C12P 7/52 (20130101) C12P 7/54 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/03 (20210101) C25B 3/26 (20210101) C25B 13/08 (20130101) C25B 15/081 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136618 | Wehner et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael Wehner (Santa Cruz, California); Keng-Yu Lin (Santa Cruz, California); Natalie King (Santa Cruz, California) |
| ABSTRACT | A passive microfluidic valve includes a first manifold portion having a first chamber; a first inlet fluidly coupled to the first chamber; and a second inlet. The valve also includes a second manifold portion in fluid communication with the first chamber via a channel. The second manifold portion includes a second chamber fluidly coupled to the first chamber and the second inlet. The valve further includes a flexible membrane disposed between the first manifold portion and the second manifold portion and separating the first chamber and the second chamber, the flexible membrane configured to modulate a flow rate of a media flowing between the first inlet and the second inlet in either direction in response to pressure of the media flow. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515792 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 2201/038 (20130101) B81B 2201/054 (20130101) Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 99/0015 (20130101) Original (OR) Class F16K 99/0057 (20130101) F16K 2099/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136937 | Deng et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Morgan State University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hua Deng (Baltimore, Maryland); Hongtao Yu (Baltimore, Maryland) |
| ABSTRACT | Fluorescence titration of methylene blue, rhodamine B and rhodamine 6G (R6G) by silver nanoparticle (AgNP) all resulted in an initial steep quenching curve followed with a sharp turn and a much flatter quenching curve. At the turn, there are about 200,000 dye molecules per a single AgNP, signifying self-assembly of approximately 36 layers of dye molecules on the surface of the AgNP to form a micelle-like structure. These fluorescence-quenching curves fit to a mathematical model with an exponential term due to molecular self-assembly on a AgNP surface, or “self-assembly shielding effect”, and a Stern-Volmer term (nanoparticle surface enhanced quenching). Such a “super-quenching” by AgNP can only be attributed to “pre-concentration” of the dye molecules on the nanoparticle surface that yields the formation of micelle-like self-assembly, resulting in great fluorescence quenching. Overall, the fluorescence quenching titration reveals three different types of interactions of dye molecules on AgNP surface: 1) self-assembly (methylene blue, rhodamine B and R6G), 2) absorption/tight interaction (tryptamine and fluorescein), and 3) loose interaction (eosin Y). We attribute the formation of micelle-like self-assembly of these three dye molecules on AgNP to their positive charge, possession of nitrogen atoms, and with relatively large and flat aromatic moieties. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401985 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 62/44 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1007 (20130101) C09K 2211/1018 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 2001/302 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136986 | Motes, III et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Research International, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Doyle T. Motes, III (Austin, Texas); Marcus Keiser (Cedar Park, Texas); Richard Piner (Austin, Texas) |
| ABSTRACT | Non-destructive sensing methods and devices for inspection and measuring in manufacturing applications for removal of contaminants from composite surfaces coupled with sensing and activation of the composite surfaces. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/472533 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/225 (20130101) G01N 23/2202 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137017 | Lazar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Aurel A. Lazar (New York, New York); Tingkai Liu (Suzhou, China PRC); Chung-Heng Yeh (Kaohsiung, Taiwan) |
| ABSTRACT | The present disclosure provides, method, a system, and apparatus for identifying odorants. For example, the apparatus performs sensing an odorant using an olfactory sensor, encoding the sensed odorant to an electrical signal using an input processor, determining an identity representation of the odorant based on the encoded electrical signal, and determining odorant information using a time-dependent hash code based on the identity representation of the odorant. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/121246 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0031 (20130101) Original (OR) Class G01N 33/0062 (20130101) G01N 2033/0068 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6215 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 60/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137162 | Romalis et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| ASSIGNEE(S) | The Trustees of Princeton University (Princeton, New Jersey) |
| INVENTOR(S) | Michael Romalis (Princeton, New Jersey); Nezih Dural (Bordentown, New Jersey); Vito-Giovanni Lucivero (Barcelona, Spain); Wonjae Lee (Princeton, New Jersey) |
| ABSTRACT | According to various embodiments, a direct magnetic gradiometer having intrinsic subtraction of rotation signals from two oppositely polarized atomic ensembles within a single multi-pass cell is disclosed. The gradiometer includes three convex spherical mirrors aligned in a V-shape geometry. The three convex spherical mirrors include a front mirror and two back mirrors. The gradiometer further includes a probe laser beam. The laser beam is configured to be initially focused at a near-zero angle into a hole at a center of the front mirror such that the laser beam expands at the back mirrors and nearly overlaps with itself while undergoing multiple reflections between the front and back mirrors. The laser beam is further configured to be refocused to the front mirror at different spots in a number equal to half of total beam passes before exiting. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/519826 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/26 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 17/004 (20130101) G02B 17/0626 (20130101) G02B 27/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137169 | ENGLUND |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | Chemical-shift nuclear magnetic resonance (NMR) spectroscopy involves measuring the effects of chemical bonds in a sample on the resonance frequencies of nuclear spins in the sample. Applying a magnetic field to the sample causes the sample nuclei to emit alternating current magnetic fields that can be detected with color centers, which can act as very sensitive magnetometers. Cryogenically cooling the sample increases the sample's polarization, which in turn enhances the NMR signal strength, making it possible to detect net nuclear spins for very small samples. Flash-heating the sample or subjecting it to a magic-angle-spinning magnetic field (instead of a static magnetic field) eliminates built-in magnetic field inhomogeneities, improving measurement sensitivity without degrading the sample polarization. Tens to hundreds of small, cryogenically cooled sample chambers can be integrated in a semiconductor substrate interlaced with waveguides that contain color centers for optically detected magnetic resonance measurements of the samples' chemical-shift NMR frequencies. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/465895 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/31 (20130101) G01R 33/46 (20130101) Original (OR) Class G01R 33/282 (20130101) G01R 33/323 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137394 | Younts et al. |
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| FUNDED BY |
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| APPLICANT(S) | United States Government as represented by the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Alexander Younts (Moncks Corner, South Carolina); Tian-Bing Xu (Chesapeake, Virginia); Laura Catherine Tolliver (Charleston, South Carolina) |
| ABSTRACT | A programmable, deformable incident-energy shaper comprising: a base having top and bottom surfaces with a perforation there-between; a protrusion connected to, and extending outwardly from, a center of the top surface; a deformable layer firmly attached to the base's perimeter and to a tip of the protrusion such that a majority of the deformable layer is suspended in free space between the tip and the perimeter, wherein the deformable layer is configured to flex inwardly or outwardly, and wherein the perforation provides a fluid channel to ambient fluid; and an actuator, operatively coupled to the deformable layer and configured to cause the deformable layer to flex inwardly or outwardly upon command. |
| FILED | Wednesday, November 04, 2020 |
| APPL NO | 17/089044 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 26/004 (20130101) G02B 26/0825 (20130101) Original (OR) Class Sound-producing Devices; Methods or Devices for Protecting Against, or for Damping, Noise or Other Acoustic Waves in General; Acoustics Not Otherwise Provided for G10K 15/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137484 | MITTAL et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunil MITTAL (Rockville, Maryland); Mohammad HAFEZI (Washington, District of Columbia) |
| ABSTRACT | Examples of the present disclosure include the use of a topological system including an array of coupled ring resonators that exhibits topological edge states to generate frequency combs and temporal dissipative Kerr solitons. The topological edge states constitute a travelling-wave super-ring resonator causing generation of at least coherent nested optical frequency combs, and self-formation of nested temporal solitons that are robust against defects in the array at a mode efficiency exceeding 50%. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515757 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3513 (20130101) Original (OR) Class G02F 1/3536 (20130101) G02F 2203/15 (20130101) G02F 2203/17 (20130101) G02F 2203/54 (20130101) G02F 2203/56 (20130101) Transmission H04B 10/506 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138233 | Ackermann et al. |
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| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher F. Ackermann (Chantilly, Virginia); Charles E. Beller (Baltimore, Maryland); Michael Drzewucki (Woodbridge, Virginia) |
| ABSTRACT | A method, system and computer-usable medium are disclosed to identify a set of entity names based on a partial name of the entity utilizing discovered relationships. A partial name from a user is received as to the entity in order to retrieve a plurality of names of the entity in a corpus which can be a body or works, document, etc. References to the entries containing the partial name are retrieved from the corpus. A natural language processing is applied to content associated with references to identify candidate entities. A similarity is performed as to the identified candidate entities to form a similarity assessment, and from the candidate entities a selection is made based on a merging criteria. |
| FILED | Wednesday, November 04, 2020 |
| APPL NO | 17/089465 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/248 (20190101) G06F 16/288 (20190101) Original (OR) Class G06F 16/24578 (20190101) G06F 40/30 (20200101) G06F 40/284 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138408 | Ackermann et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher F. Ackermann (Fairfax, Virginia); Charles E. Beller (Baltimore, Maryland); Michael Drzewucki (Woodbridge, Virginia) |
| ABSTRACT | An embodiment for extracting information from semi-structured text is provided. The embodiment may include identifying one or more high confidence alignments of one or more entities and identifiers in a set of documents. The embodiment may also include analyzing one or more blocks of semi-structured text containing the one or more entities and identifiers. The embodiment may further include identifying one or more known alignments in each of the one or more blocks of semi-structured text. The embodiment may also include generating a structure template. The embodiment may further include applying the structure template to each of the one or more blocks of semi-structured text. The embodiment may also include annotating the set of documents with metadata reflecting the structure template and a location of each of the one or more blocks of semi-structured text. |
| FILED | Tuesday, November 03, 2020 |
| APPL NO | 17/087994 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/84 (20190101) G06F 40/169 (20200101) Original (OR) Class G06F 40/186 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138472 | Mittal et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Trisha Mittal (College Park, Maryland); Uttaran Bhattacharya (College Park, Maryland); Rohan Chandra (College Park, Maryland); Aniket Bera (Greenbelt, Maryland); Dinesh Manocha (Greenbelt, Maryland) |
| ABSTRACT | A video is classified as real or fake by extracting facial features, including facial modalities and facial emotions, and speech features, including speech modalities and speech emotions, from the video. The facial and speech modalities are passed through first and second neural networks, respectively, to generate facial and speech modality embeddings. The facial and speech emotions are passed through third and fourth neural networks, respectively, to generate facial and speech emotion embeddings. A first distance, d1, between the facial modality embedding and the speech modality embedding is generated, together with a second distance, d2, between the facial emotion embedding and the speech emotion embedding. The video is classified as fake if a sum of the first distance and the second distance exceeds a threshold distance. The networks may be trained using real and fake video pairs for multiple subjects. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515846 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00302 (20130101) G06K 9/00718 (20130101) Original (OR) Class G06K 9/00744 (20130101) G06K 9/00758 (20130101) G06K 9/6215 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) G06N 3/0454 (20130101) G06N 3/0481 (20130101) Speech Analysis or Synthesis; Speech Recognition; Speech or Voice Processing; Speech or Audio Coding or Decoding G10L 25/30 (20130101) G10L 25/63 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138608 | Ramette et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Joshua Ramette (Cambridge, Massachusetts); Josiah Sinclair (Cambridge, Massachusetts); Vladan VULETIC (Cambridge, Massachusetts) |
| ABSTRACT | An all-to-all coupled, high-fidelity, error-correctable quantum computer can scale to hundreds of qubits within a single cavity of moderate cooperativity with existing neutral atom technology. This quantum processor can enact teleported gates among any pair of qubits using a local Rydberg interaction between each qubit and a separate network of atoms that distribute entanglement via a cavity mode. Small atomic ensembles at network nodes allow for ultrafast, nondestructive readout with high fidelity by substantially shifting the resonance of even a poor-quality cavity. Fast readout enables near-deterministic entanglement distribution among network atoms despite cavity losses as well as syndrome measurements of qubit atoms for error correction. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/460385 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/30101 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138652 | Simeone et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Michael P. Simeone (Scottsdale, Arizona); David Little (Mesa, Arizona); George Boben (Fort Worth, Texas); Shashank Kapoor (New Delhi, India); Deepan Nedumaran (Tempe, Arizona); Aravind Sundaresan (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael P. Simeone (Scottsdale, Arizona); David Little (Mesa, Arizona); George Boben (Fort Worth, Texas); Shashank Kapoor (New Delhi, India); Deepan Nedumaran (Tempe, Arizona); Aravind Sundaresan (Tempe, Arizona) |
| ABSTRACT | A system for failure detection tools is disclosed. The system may include at least one user device, an application server, and a failure detection system, each of which may be in communication with one or more of the others via at least one network. The failure detection system may receive first data from a data source, process the first data to generate second data, apply a statistical modeling algorithm to make a prediction relating to the first data or the second data, and communicate data relating to the prediction and/or a trend related to the first data or the second data to the user device for displaying at least a portion of the data relating to the prediction and/or the trend on a display of the user device. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513533 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/54 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0633 (20130101) G06Q 10/06312 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138911 | NEWEY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Michael NEWEY (Chelmsford, Massachusetts); Prafull SHARMA (Cambridge, Massachusetts) |
| ABSTRACT | A neural network is used to remove noise from a data signal. The noise removed by the neural network is compared to simulated noise that represents noise expected to be present in the data signal. The results of the comparison are used to train the neural network and improve its ability to remove noise from the data signal |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/519929 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 17/89 (20130101) Computer Systems Based on Specific Computational Models G06N 3/088 (20130101) G06N 3/0454 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) Original (OR) Class G06T 5/50 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/20224 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138939 | Jalali et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Bahram Jalali (Oakland, California); Madhuri Suthar (Oakland, California); Cejo Konuparamban Lonappan (Oakland, California); Antoni Ribas (Oakland, California); Theodore Scott Nowicki (Oakland, California); Jia Ming Chen (Oakland, California) |
| ABSTRACT | Systems and methods for digital pathology in accordance with embodiments of the invention obtain a whole slide image of a microscope slide that includes a registration mark, wherein the registration mark is associated with a coordinate system. The method inputs the whole slide image into a region identification (RI) model to extract features of the whole slide image and generate feature vectors for the extracted features, detects a presence of a region of interest (ROI) based on the feature vectors, determines a set of coordinates of the ROI in the coordinate system, and translates a microscope stage of a microscope holding the microscope slide to a position corresponding to the coordinates of the ROI. The method captures a field of view (FOV) image with the microscope and inputs the FOV image into a grading model to determine a pathology score that indicates a likelihood of a presence of a disease. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/431138 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/365 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) Original (OR) Class G06T 2207/10056 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30024 (20130101) Image or Video Recognition or Understanding G06V 10/25 (20220101) G06V 10/40 (20220101) G06V 20/693 (20220101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/40 (20180101) G16H 30/40 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220139031 | Young et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRX Systems, Inc. (Greenbelt, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Travis Young (Rockville, Maryland); Daniel Hakim (Silver Spring, Maryland); Daniel Franchy (Catonsville, Maryland); Jared Napora (Severn, Maryland); John Karvounis (Bowie, Maryland); Jonathan Fetter Degges (Washington, District of Columbia); Tim Wang (Germantown, Maryland); Benjamin Funk (Hanover, Maryland); Carole Teolis (Glendale, Maryland); Carol Politi (Bethesda, Maryland); Stuart Woodbury (Ellicott City, Maryland) |
| ABSTRACT | Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device. |
| FILED | Wednesday, September 15, 2021 |
| APPL NO | 17/475935 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/13 (20200101) Image Data Processing or Generation, in General G06T 17/05 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220139077 | Bushmitch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis Bushmitch (Somerset, New Jersey); Michael Badger (Ocean Grove, New Jersey) |
| ABSTRACT | Various embodiments associated with a composite image are described. In one embodiment, a handheld device comprises a launch component configured to cause a launch of a projectile. The projectile is configured to capture a plurality of images. Individual images of the plurality of images are of different segments of an area. The system also comprises an image stitch component configured to stitch the plurality of images into a composite image. The composite image is of a higher resolution than a resolution of individual images of the plurality of images. |
| FILED | Thursday, January 20, 2022 |
| APPL NO | 17/579712 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/123 (20130101) Image Data Processing or Generation, in General G06T 3/4038 (20130101) G06T 3/4053 (20130101) G06T 5/50 (20130101) G06T 7/33 (20170101) G06T 7/38 (20170101) G06T 11/60 (20130101) G06T 2207/10032 (20130101) G06T 2207/30181 (20130101) G06T 2207/30212 (20130101) Image or Video Recognition or Understanding G06V 10/16 (20220101) G06V 20/13 (20220101) Original (OR) Class G06V 20/52 (20220101) Pictorial Communication, e.g Television H04N 5/28 (20130101) H04N 5/2624 (20130101) H04N 5/23238 (20130101) H04N 5/23293 (20130101) H04N 7/185 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220139687 | Campbell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Spark Thermionics, Inc. (Berkeley, California); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew Campbell (Philadelphia, Pennsylvania); Mohsen Azadi (Philadelphia, Pennsylvania); Kyana Van Houten (Berkeley, California); Jared William Schwede (Berkeley, California); Samuel M. Nicaise (Philadelphia, Pennsylvania); Igor Bargatin (Wynnewood, Pennsylvania) |
| ABSTRACT | A small-gap device system, preferably including two or more electrodes and one or more spacers maintaining a gap between two or more of the electrodes. A spacer for a small-gap device system, preferably including a plurality of legs defining a mesh structure. A method of spacer and/or small-gap device fabrication, preferably including: defining lateral features, depositing spacer material, selectively removing spacer material, separating the spacer from a fabrication substrate, and/or assembling the small-gap device. |
| FILED | Friday, January 22, 2021 |
| APPL NO | 17/155638 |
| CURRENT CPC | Electric Discharge Tubes or Discharge Lamps H01J 45/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140330 | Atwater et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government, as represented by the Secretary of the Army (Aberdeen Proving Ground, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Terrill B. Atwater (Bel Air, Maryland); Matthew A. Limpert (Kennett Square, Pennsylvania); Ashley L. Ruth (Bel Air, Maryland); Paula C. Latorre (Bel Air, Maryland) |
| ABSTRACT | A process for preparing a cathode material comprising a compound of the form LiaMn1-x-zFexNizO2-dCld is provided. In addition, a LiaMn1-x-zFexNizO2-dCld cathode material for electrochemical systems is provided. Furthermore, a lithium or lithium-ion rechargeable electrochemical cell is provided, incorporating the LiaMn1-x-zFexNizO2-dCld cathode material in a positive electrode. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/574496 |
| CURRENT CPC | Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 53/006 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/50 (20130101) C01P 2002/72 (20130101) C01P 2002/85 (20130101) C01P 2006/40 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/505 (20130101) Original (OR) Class H01M 4/525 (20130101) H01M 10/0525 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140463 | Schuster et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Schuster (Chicago, Illinois); Aziza Suleymanzade (Cambridge, Massachusetts); Jonathan Simon (Chicago, Illinois); Alexander Anferov (Chicago, Illinois) |
| ABSTRACT | A millimeter-wave resonator is produced by drilling a plurality of holes into a piece of metal. Each hole forms an evanescent tube having a lowest cutoff frequency. The holes spatially intersect to form a seamless three-dimensional cavity whose fundamental cavity mode has a resonant frequency that is less than the cutoff frequencies of all the evanescent tubes. Below cutoff, the fundamental cavity mode does not couple to the waveguide modes, and therefore has a high internal Q. Millimeter waves can be coupled into any of the tubes to excite an evanescent mode that couples to the fundamental cavity mode. The tubes also provide spatial and optical access for transporting atoms into the cavity, where they can be trapped while spatially overlapping the fundamental cavity mode. The piece of metal may be superconducting, allowing the resonator to be used in a cryogenic environment for quantum computing and information processing. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/452654 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/04 (20130101) Original (OR) Class H01P 11/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140492 | Huggers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Vadient Optics LLC (Beaverton, Oregon) |
| ASSIGNEE(S) | Vadient Optics LLC (Beaverton, Oregon) |
| INVENTOR(S) | Peter G. Huggers (Eugene, Oregon); Chad N. Teters (Oregon City, Oregon); Ernst Adrian Henle (Eugene, Oregon); Thomas Leonard Allen (Milwaukie, Oregon); John Paul Harmon (Albany, Oregon); Samuel Peter Grimm (Philomath, Oregon); Edward Whitney Eliott, III (Eugene, Oregon); Peter Jon Polesnak (Eugene, Oregon) |
| ABSTRACT | A method of additively manufacturing a composite article with tuned impedance and refractive-index in three dimensions. The method includes providing a ferrite feedstock. The ferrite feedstock is loaded with ferrite particles. The method further includes depositing and curing the ferrite feedstock. Therein a composite article is formed. |
| FILED | Wednesday, June 12, 2019 |
| APPL NO | 16/439493 |
| CURRENT CPC | Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 70/10 (20200101) B33Y 80/00 (20141201) Antennas, i.e Radio Aerials H01Q 15/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220141248 | VELA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Booz Allen Hamilton Inc. (McLean, Virginia) |
| ASSIGNEE(S) | Booz Allen Hamilton Inc. (McLean, Virginia) |
| INVENTOR(S) | Chelsea VELA (San Antonio, Texas); Justin HOFFMAN (Boerne, Texas) |
| ABSTRACT | A system for generating a cyber-attack to penetrate a network. The system includes an identification module configured to identify at least one vulnerability of the network by examining at least one of a node of the network, data transmission within the network, or data received from a cyber defense mechanism; a generation module configured to generate a cyber-attack based on the at least one vulnerability of the network, and a goal to be achieved by the cyber-attack. The system includes a penetration module configured to penetrate the network with the cyber-attack and determine an effectiveness rating of the penetration; and a feedback module configured to provide a feedback to the identification module based on at least the effectiveness rating of the penetration. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/575917 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) H04L 63/1433 (20130101) Original (OR) Class H04L 63/1466 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220141821 | D'ORO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Salvatore D'ORO (Allston, Massachusetts); Francesco RESTUCCIA (Boston, Massachusetts); Tommaso MELODIA (Newton, Massachusetts) |
| ABSTRACT | Methods and systems for allocating radio access network (RAN) spectrum resources among a plurality of mobile virtual network operators (MVNOs) of a network of base stations. The methods and systems include determining a slicing enforcement policy that assigns resource blocks (RBs) of frequency units and time slots of spectrum resources to each MVNO according to a slicing policy in which each MVNO is allocated an amount of the spectrum resources on at least one base station in a determined time span. The slicing enforcement policy minimizes overlap between each MVNO's set of RBs with another MVNO's set of RBs on a same base station, and interference between each MVNO's set of RBs with another MVNO's set of RBs on an interfering base station. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/424522 |
| CURRENT CPC | Wireless Communication Networks H04W 16/10 (20130101) H04W 16/14 (20130101) H04W 48/18 (20130101) H04W 72/0453 (20130101) Original (OR) Class H04W 84/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220142004 | Griffin et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Jonathan C. Griffin (Westford, Massachusetts); Ross T. Johnson (Nashua, New Hampshire); Gregory J. Wunsch (Milford, New Hampshire) |
| ABSTRACT | A heat dissipation structure is disclosed that is especially well-suited for use on aerodynamic systems. The heat dissipation structure is formed within a metallic body that surrounds the heat-generating electronics. The heat dissipation structure is designed to both dissipate the generated heat and also to isolate RF cross-talk between the one or more transmitters and receivers. The heat dissipation structure includes a plurality of ring structures that extend around at least a portion of a body that houses the one or more heat-generating electrical components. The plurality of ring structures may be recessed into the body, and a first spacing between a first adjacent pair of ring structures of the plurality of ring structures is different from a second spacing between a second adjacent pair of ring structures of the plurality of ring structures. |
| FILED | Thursday, November 05, 2020 |
| APPL NO | 17/090341 |
| CURRENT CPC | Weapon Sights; Aiming F41G 7/224 (20130101) F41G 7/2246 (20130101) Transmission H04B 15/02 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20418 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220132835 | Bischof et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John C. Bischof (St. Paul, Minnesota); Michael L. Etheridge (St. Louis Park, Minnesota); Jeunghwan Choi (Winterville, North Carolina) |
| ABSTRACT | This disclosure describes compositions and methods related to cryoprotection of biomaterial. Generally, the cryoprotective composition includes a cryoprotective agent and magnetic nanoparticles effective for thawing a cryopreserved specimen comprising biomaterial with minimal biomaterial damage. In some embodiments, the composition is effective for thawing a cryopreserved specimen having a minimum dimension of 0.1 mm. Generally, the method includes obtaining a biomaterial cryopreserved with a cryoprotective composition as summarized above, then subjecting the cryopreserved biomaterial to electromagnetic energy of an intensity sufficient to excite the magnetic nanoparticles and thaw the biomaterial. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/579369 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 1/0221 (20130101) Original (OR) Class A01N 1/0242 (20130101) A01N 1/0284 (20130101) A01N 1/0294 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 13/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220132839 | Riffell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Jeffrey A. Riffell (Seattle, Washington); Chloé Lahondère (Seattle, Washington); Clément Vinauger (Seattle, Washington) |
| ABSTRACT | Mosquito attractant composition for attracting a mosquito to a pre-determined location. The composition includes a combination of nonanal and lilac aldehydes. |
| FILED | Thursday, February 20, 2020 |
| APPL NO | 17/431869 |
| CURRENT CPC | Catching, Trapping or Scaring of Animals; Apparatus for the Destruction of Noxious Animals or Noxious Plants A01M 1/2016 (20130101) A01M 29/12 (20130101) Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 31/02 (20130101) Original (OR) Class A01N 31/04 (20130101) A01N 43/08 (20130101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 17/00 (20210801) A01P 19/00 (20210801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220132880 | DiMaio et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Epogee, LLC (Indianapolis, Indiana) |
| ASSIGNEE(S) | Epogee, LLC (Indianapolis, Indiana) |
| INVENTOR(S) | Jeffrey R. DiMaio (Pendleton, South Carolina); Peter Gennaro (Mount Pleasant, South Carolina); Zach Hunt (Simpsonville, South Carolina) |
| ABSTRACT | Certain characteristics of esterified propoxylated glycerol compositions and reduced-fat food products prepared therefrom may be modified and improved by combining such esterified propoxylated glycerol compositions with particular triglyceride compositions having higher melting points, wherein the melting and crystallization properties of each component are taken into account when selecting them for combination. For instance, EPG-based confectionary products having reduced issues with slump, blocking and demolding may be prepared by incorporating such a higher melting triglyceride composition, without compromising the organoleptic qualities of the resulting confectionary. |
| FILED | Wednesday, November 10, 2021 |
| APPL NO | 17/454330 |
| CURRENT CPC | Edible Oils or Fats, e.g Margarines, Shortenings, Cooking Oils A23D 7/003 (20130101) Original (OR) Class Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/04 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) A23V 2200/232 (20130101) A23V 2250/1944 (20130101) A23V 2250/1946 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220132891 | Sheth et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Imvela Corp. (Brooklyn, New York) |
| ASSIGNEE(S) | Imvela Corp. (Brooklyn, New York) |
| INVENTOR(S) | Ravi Sheth (Brooklyn, New York); Kendall Dabaghi (Brooklyn, New York); Felix Ekness (Brooklyn, New York); Miriam Shiffman (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein are fermented beverages comprising symbiotic microbial communities, and methods of production thereof. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/515358 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 2/382 (20130101) Original (OR) Class A23L 33/135 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133159 | Ansari et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sardar Ansari (Ypsilanti, Michigan); Kenn Oldham (Ann Arbor, Michigan); Kevin R. Ward (Superior Township, Michigan); Kayvan Najarian (Northville, Michigan); Lu Wang (Ann Arbor, Michigan) |
| ABSTRACT | A method for noninvasively measuring hemodynamic variables of a person includes physically configuring a sensor to measure the pulse of a person. The sensor generates a pulse waveform indicative of the pulse of the person. A processor obtains the pulse waveform from the sensor and the processor determines a reflection coefficient and reflection delay between an incident and a reflected wave, from which the processor determines the hemodynamic variables of the person from the reflection coefficient and the reflection delay. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514939 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/02116 (20130101) Original (OR) Class A61B 5/02125 (20130101) A61B 5/6819 (20130101) A61B 5/6822 (20130101) A61B 5/6823 (20130101) A61B 5/6824 (20130101) A61B 5/6826 (20130101) A61B 5/6828 (20130101) A61B 5/6829 (20130101) A61B 5/6831 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133639 | Thayumanavan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sankaran Thayumanavan (Amherst, Massachusetts); Jiaming Zhuang (Amherst, Massachusetts); Hui Wang (Sunderland, Massachusetts) |
| ABSTRACT | The invention generally relates to polymer-based nano-structures. More particularly, the invention relates to novel, surface-functionalized, guest-host polymer nano-assemblies and nano-delivery vehicles useful in diverse fields including drug delivery, diagnostics and specialty materials. The nano-assemblies and nano-delivery vehicles of the invention are afforded via simplify and reliable approaches. |
| FILED | Saturday, July 31, 2021 |
| APPL NO | 17/390912 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5138 (20130101) Original (OR) Class A61K 9/5146 (20130101) A61K 47/6903 (20170801) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220133893 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yupeng Chen (Farmington, Connecticut); Jinhyung Lee (Farmington, Connecticut) |
| ABSTRACT | Disclosed herein is a delivery vehicle based on DNA-inspired Janus based nanotubes (JBNTs) for anti-viral treatment. The nanoparticles (NPs) are based the JBNTs conjugated with targeting moieties such as small molecules, aptamers, and peptides. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514390 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/51 (20130101) A61K 31/194 (20130101) A61K 31/519 (20130101) A61K 31/721 (20130101) A61K 31/722 (20130101) A61K 31/727 (20130101) A61K 31/728 (20130101) A61K 38/19 (20130101) A61K 38/40 (20130101) A61K 38/363 (20130101) A61K 38/385 (20130101) A61K 47/65 (20170801) A61K 47/545 (20170801) Original (OR) Class A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220134337 | Aksimentiev |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| INVENTOR(S) | Aleksei Aksimentiev (Urbana, Illinois) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane, wherein the membrane has a first side and a second side, wherein the membrane has a first pore disposed therein, wherein the first pore extends through the membrane from the first side of the membrane to the second side of the membrane, wherein the membrane has a second pore disposed therein, and wherein the second pore extends through the membrane from the first side of the membrane to the second side of the membrane; a first channel disposed on the first side of the membrane, wherein the first channel is along a first longitudinal axis; a second channel disposed on the first side of the membrane, wherein the second channel is along a second longitudinal axis, and wherein the first channel and the second channel are disposed side by side adjacent to each other; a third channel disposed on the second side of the membrane, wherein the third channel is along a third longitudinal axis, wherein the third channel is in first fluid communication with the first channel via the first pore, and wherein the third channel is in second fluid communication with the second channel via the second pore; and one or more sensors disposed at one or more locations to facilitate sequencing of a molecule that extends from the first channel, through the first pore across at least a portion of the third channel, and through the second pore into the second channel. Additional embodiments are disclosed. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513516 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502715 (20130101) Original (OR) Class B01L 2200/0652 (20130101) B01L 2300/0663 (20130101) B01L 2300/0896 (20130101) B01L 2400/0415 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220134340 | Tu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Texas A and M University System (College Station, Texas) |
| ASSIGNEE(S) | The Texas A and M University System (College Station, Texas) |
| INVENTOR(S) | Dandan Tu (College Station, Texas); Gerard L. Coté (College Station, Texas); Samuel Mabbott (College Station, Texas); John Dean (College Station, Texas) |
| ABSTRACT | In an embodiment, the present disclosure pertains to a microfluidic device composed of a substrate having an inlet region and a first storage region, a fluid transporting channel in fluid communication with the inlet region, an expandable component in fluid communication with the fluid transporting channel and coupled to a movable arm, and a fluid transporting region coupled to the movable arm and operable to be moved in a horizontal direction to the fluid transporting channel to thereby form fluidic contact between the inlet region and the first storage region upon expansion of the expandable component. In an additional embodiment, the present disclosure pertains to a method of fluid flow utilizing a microfluidic device of the present disclosure. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/512787 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/567 (20130101) B01L 3/50273 (20130101) B01L 3/502707 (20130101) B01L 3/502746 (20130101) Original (OR) Class B01L 2300/126 (20130101) B01L 2300/0816 (20130101) B01L 2400/06 (20130101) B01L 2400/0677 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/115 (20130101) C12N 2310/16 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) G01N 33/5308 (20130101) G01N 33/6893 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135412 | Waterman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rory Waterman (Burlington, Vermont); Brandon Ackley (Burlington, Vermont) |
| ABSTRACT | Methods of making a ceramic of a Group 13-15 type or a Group 13-15-16 type by thermolyzing a discrete molecular precursor to the ceramic in an oxygen-containing atmosphere. In some embodiments, the discrete molecular precursor is bench-stable and comprises a Lewis acid-base pair or small cyclic compound containing at last one Group 13 element and at least one Group 15 element but does not include indium and phosphorus in combination with one another unless a Group 16 element is present. The thermolysis can be carried out in air, at atmospheric pressure, and at a temperature below about 400° C., if desired. In some embodiments, the discrete molecular precursor can be placed in a mold having a desired shape and the thermolysis performed while the discrete molecular precursor is in the mold so as to produce a ceramic product having the desired shape. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/433276 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 25/087 (20130101) C01B 35/04 (20130101) C01B 35/14 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/88 (20130101) C01P 2004/03 (20130101) C01P 2006/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135413 | Hamers et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Hamers (Madison, Wisconsin); Benjamin Bachman (Madison, Wisconsin) |
| ABSTRACT | Improved methods of synthesizing ammonia from hydrogen sulfide and lithium nitrate are disclosed. Specifically, in a continuous cycle, hydrogen sulfide reactant is regenerated from the elemental sulfur that is extracted from a product of the ammonia synthesis, and the regenerated hydrogen sulfide is fed back into the ammonia synthesis reaction. The cycle that regenerates the hydrogen sulfide uses either a water-containing or a water and carbon-containing feedstock to facilitate the regeneration of the hydrogen sulfide from the elemental sulfur. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514956 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 19/245 (20130101) B01J 19/2445 (20130101) B01J 19/2465 (20130101) Non-metallic Elements; Compounds Thereof; C01B 17/74 (20130101) Ammonia; Cyanogen; Compounds Thereof C01C 1/026 (20130101) Original (OR) Class Acyclic or Carbocyclic Compounds C07C 273/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135604 | Koide |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kazunori Koide (Pittsburgh, Pennsylvania) |
| ABSTRACT | Provided herein is a fluorogenic probe that selectively undergoes a [2,3]-sigmatropic rearrangement (seleno-Mislow-Evans rearrangement) with H2O2, followed by an acetal hydrolysis, to produce a green fluorescent molecule in seconds. Also provided herein is a method of identifying or visualizing the presence of H2O2 in a cell, tissue, organ, or organism that includes contacting the cell, tissue, organ, or organism with the fluorogenic probe. Also provided herein is a method of identifying or quantifying the presence of H2O2 in a sample that includes adding to or mixing in the sample the fluorogenic probe. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514356 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 11/00 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/643 (20130101) G01N 33/84 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135709 | Veige et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INCORPORATED (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam S. Veige (Gainesville, Florida); Chrisropher D. Roland (Danville, California) |
| ABSTRACT | Provided herein are complexes for polymerization of linear alkynes to cyclic poly(alkynes), and methods of making and using same. For example, provided herein are compounds of formula (I) or formula (IV): |
| FILED | Tuesday, March 03, 2020 |
| APPL NO | 17/436420 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 4/78 (20130101) Original (OR) Class C08F 8/04 (20130101) C08F 38/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135923 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Georgia Research Foundation, Inc. (Athens, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yongwook Kim (Athens, Georgia); Amine Laradji (St. Louis, Missouri); Sergiy Minko (Athens, Georgia); Nataraja Sekhar Yadavalli (Athens, Georgia) |
| ABSTRACT | Dynamic polymer surfaces are provided that include alternating micropatterns of adhesive domains and environmental stimuli-responsive repulsive domains, where application of a select environmental stimulus activates polymer structures of the repulsive domains to change conformation with respect to the adhesive domains. The dynamic polymer surfaces are useful for sorting, screening, and enriching target particles (such as cells) in a sample and for culturing and harvesting cells. Products, such as cell culture systems, including the dynamic polymer surfaces are also provided. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514795 |
| CURRENT CPC | Compositions of Macromolecular Compounds C08L 33/26 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 25/08 (20130101) Original (OR) Class C12M 33/00 (20130101) C12M 35/02 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/02 (20130101) C12N 1/04 (20130101) C12N 2513/00 (20130101) C12N 2529/00 (20130101) C12N 2533/30 (20130101) C12N 2535/10 (20130101) C12N 2539/10 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/38 (20130101) G03F 7/162 (20130101) G03F 7/325 (20130101) G03F 7/0382 (20130101) G03F 7/2004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135925 | Reiserer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); Gregory B. Gerken (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578966 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/08 (20130101) C12M 23/10 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/50 (20130101) C12M 23/58 (20130101) C12M 27/02 (20130101) C12M 27/12 (20130101) C12M 29/10 (20130101) Original (OR) Class C12M 35/02 (20130101) C12M 35/04 (20130101) C12M 41/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135953 | Lippmann et al. |
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| FUNDED BY |
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| APPLICANT(S) | Vanderbilt University (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ethan S. Lippmann (Nashville, Tennessee); Kylie Balotin (Nashville, Tennessee); Brian O'Grady (Nashville, Tennessee); Leon M. Bellan (Nashville, Tennessee) |
| ABSTRACT | Provided are biomaterials useful for cell culture, method of preparation thereof, and use thereof. The present biomaterial comprises a crosslinked hydrogel and a peptide chemically attached to the hydrogel, wherein the peptide comprises a histidine-alanine-valine (HAV) sequence. In particular, the present biomaterial may be useful for culturing neurons, brain endothelial cells, and/or glial cells, supporting the formation of synaptically connected neural networks, and growing stem cell-derived organoids that more closely resemble human organs. |
| FILED | Friday, February 21, 2020 |
| APPL NO | 17/429540 |
| CURRENT CPC | Derivatives of Natural Macromolecular Compounds C08H 1/06 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/24 (20130101) C08J 3/075 (20130101) C08J 2389/06 (20130101) Compositions of Macromolecular Compounds C08L 89/06 (20130101) C08L 2312/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 5/0622 (20130101) C12N 5/0691 (20130101) C12N 5/0697 (20130101) Original (OR) Class C12N 2502/081 (20130101) C12N 2502/086 (20130101) C12N 2506/45 (20130101) C12N 2513/00 (20130101) C12N 2533/54 (20130101) C12N 2537/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135997 | SCHULTINK et al. |
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| FUNDED BY |
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| APPLICANT(S) | Fortiphyte, Inc. (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Christiaan SCHULTINK (Berkeley, California); Laura A. WETZEL (Berkeley, California) |
| ABSTRACT | The present disclosure provides an isolated, recombinant, or synthetic polynucleotide comprising a FIT1 protein, and homologs, fragments, and variations thereof. The disclosure further relates to transgenic plants, plant parts, and plant cells comprising one or more of these polynucleotides, and exhibit resistance or tolerance to a pathogen, such as Phakopsora pachyrhizi. The disclosure further relates to methods of genetically engineering a pathogen resistance or tolerance trait in a plant, plant part, or plant cell, comprising targeted gene editing of a FIT1 homolog, and plants produced therefrom. The disclosure further relates to methods for identifying new functional FIT1 genes and/or alleles thereof. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512329 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/902 (20130101) C12N 15/8282 (20130101) Original (OR) Class C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136092 | Rajagopalan et al. |
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| FUNDED BY |
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| APPLICANT(S) | Jagannathan Rajagopalan (Tempe, Arizona); Paul Rasmussen (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jagannathan Rajagopalan (Tempe, Arizona); Paul Rasmussen (Tempe, Arizona) |
| ABSTRACT | Methods for controlled microstructure creation utilize seeding of amorphous layers prior to annealing. Seed crystals are formed on an amorphous layer or layers. The material, size, and spacing of the seed crystals may be varied, and multiple seed layers and/or amorphous layers may be utilized. Thereafter, the resulting assembly is annealed to generate a crystalline microstructure. Via use of these methods, devices having desirable microstructural properties are enabled. |
| FILED | Wednesday, August 18, 2021 |
| APPL NO | 17/405194 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 14/024 (20130101) Original (OR) Class C23C 14/5806 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136119 | Flanders et al. |
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| FUNDED BY |
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| APPLICANT(S) | Opus 12 Incorporated (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas H. Flanders (San Francisco, California); Kendra P. Kuhl (Oakland, California); Etosha R. Cave (Berkeley, California); Sichao Ma (Dublin, California); Ziyang Huo (Moraga, California); Carter S. Haines (Berkeley, California); Timothy A. Bekkedahl (Sunnyvale, California); Kathryn L. Corp (Berkeley, California); Ashley D. Mishra (Danville, California); Edward Izett (Berkeley, California) |
| ABSTRACT | A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/444356 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/08 (20130101) B01J 20/10 (20130101) B01J 20/20 (20130101) B01J 20/3483 (20130101) B01J 2220/42 (20130101) Apparatus for Enzymology or Microbiology; C12M 43/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/023 (20130101) C12P 7/06 (20130101) C12P 7/16 (20130101) C12P 7/52 (20130101) C12P 7/54 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/03 (20210101) C25B 3/26 (20210101) C25B 13/08 (20130101) C25B 15/081 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136133 | SINGH et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manish SINGH (Chicago, Illinois); Tian ZHONG (Chicago, Illinois); Supratik GUHA (Chicago, Illinois) |
| ABSTRACT | The present disclosure includes a thin film assembly comprising a substrate and an epitaxial crystalline thin film disposed on the substrate, wherein the epitaxial crystalline thin film is a single crystal, wherein at least a portion of the epitaxial crystalline thin film is doped with rare-earth ions at a concentration of less than 100 parts per billion. The disclosure further includes a method of manufacturing a thin film assembly, the method comprising creating, on a substrate and with use of molecular beam epitaxy, an epitaxial crystalline thin film doped with the rare-earth ions at a concentration of less than 100 parts per billion. |
| FILED | Thursday, March 05, 2020 |
| APPL NO | 17/434221 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/02 (20130101) Original (OR) Class C30B 29/16 (20130101) C30B 29/32 (20130101) C30B 33/08 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/126 (20130101) H01F 41/302 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136136 | Parker et al. |
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| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin Kit Parker (Cambridge, Massachusetts); Grant Michael Gonzalez (Somerville, Massachusetts); Holly M. Golecki (Urbana, Illinois); Kwanwoo Shin (Seoul, South Korea); Josue A. Goss (Rogers, Arkansas) |
| ABSTRACT | Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501005 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/18 (20130101) C08J 2377/10 (20130101) Mechanical Methods or Apparatus in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons D01D 5/06 (20130101) D01D 5/18 (20130101) Original (OR) Class Chemical Features in the Manufacture of Artificial Filaments, Threads, Fibres, Bristles or Ribbons; Apparatus Specially Adapted for the Manufacture of Carbon Filaments D01F 6/605 (20130101) D01F 9/00 (20130101) Indexing Scheme Associated With Sublasses of Section D, Relating to Textiles D10B 2331/021 (20130101) Technical Subjects Covered by Former US Classification Y10T 428/249921 (20150401) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136937 | Deng et al. |
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| FUNDED BY |
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| APPLICANT(S) | Morgan State University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hua Deng (Baltimore, Maryland); Hongtao Yu (Baltimore, Maryland) |
| ABSTRACT | Fluorescence titration of methylene blue, rhodamine B and rhodamine 6G (R6G) by silver nanoparticle (AgNP) all resulted in an initial steep quenching curve followed with a sharp turn and a much flatter quenching curve. At the turn, there are about 200,000 dye molecules per a single AgNP, signifying self-assembly of approximately 36 layers of dye molecules on the surface of the AgNP to form a micelle-like structure. These fluorescence-quenching curves fit to a mathematical model with an exponential term due to molecular self-assembly on a AgNP surface, or “self-assembly shielding effect”, and a Stern-Volmer term (nanoparticle surface enhanced quenching). Such a “super-quenching” by AgNP can only be attributed to “pre-concentration” of the dye molecules on the nanoparticle surface that yields the formation of micelle-like self-assembly, resulting in great fluorescence quenching. Overall, the fluorescence quenching titration reveals three different types of interactions of dye molecules on AgNP surface: 1) self-assembly (methylene blue, rhodamine B and R6G), 2) absorption/tight interaction (tryptamine and fluorescein), and 3) loose interaction (eosin Y). We attribute the formation of micelle-like self-assembly of these three dye molecules on AgNP to their positive charge, possession of nitrogen atoms, and with relatively large and flat aromatic moieties. |
| FILED | Friday, August 13, 2021 |
| APPL NO | 17/401985 |
| CURRENT CPC | Organic Dyes or Closely-related Compounds for Producing Dyes; Mordants; Lakes C09B 62/44 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1007 (20130101) C09K 2211/1018 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) Original (OR) Class G01N 2001/302 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136972 | LEE et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ki-Bum LEE (Monmouth Junction, New Jersey); Letao YANG (Edison, New Jersey) |
| ABSTRACT | A surface-enhanced Raman scattering (SERS) sensing system or platform and methods of using the same, where the platform comprises a graphene coated-homogeneous plasmonic metal hybrid array, which synergizes both electromagnetic mechanism (EM)- and chemical mechanism (CM)-based signal enhancement for achieving sensitive and reproducible detection of Raman signals. The system and methods of using such system or platform may be applied to the analyses of various bio/chemical molecules, such as but not limited to those found in cells, in a highly sensitive and selective manner. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512211 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6876 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) Original (OR) Class G01N 33/54306 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136973 | Rodriguez et al. |
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| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebeca S. Rodriguez (St. Paul, Minnesota); Victoria M. Szlag (St. Paul, Minnesota); Theresa M. Reineke (Vadnais Heights, Minnesota); Christy L. Haynes (Minneapolis, Minnesota) |
| ABSTRACT | Methods and systems related to a linear polymer affinity agent sensor for SERS are disclosed. Use of the sensor may include mixing a linear polymer affinity agent in a sample solution, subjecting a metal substrate to the sample solution to attach the linear polymer affinity agent to the metal substrate, generating, via Raman Spectroscopy, spectral data representing the at least one linear polymer affinity agent attached to the metal substrate, and determining whether two or more analytes are present in the solution at respective minimum threshold concentrations based on the spectral data. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/514016 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/658 (20130101) Original (OR) Class G01N 33/553 (20130101) G01N 33/54373 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137017 | Lazar et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| INVENTOR(S) | Aurel A. Lazar (New York, New York); Tingkai Liu (Suzhou, China PRC); Chung-Heng Yeh (Kaohsiung, Taiwan) |
| ABSTRACT | The present disclosure provides, method, a system, and apparatus for identifying odorants. For example, the apparatus performs sensing an odorant using an olfactory sensor, encoding the sensed odorant to an electrical signal using an input processor, determining an identity representation of the odorant based on the encoded electrical signal, and determining odorant information using a time-dependent hash code based on the identity representation of the odorant. |
| FILED | Monday, December 14, 2020 |
| APPL NO | 17/121246 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/0031 (20130101) Original (OR) Class G01N 33/0062 (20130101) G01N 2033/0068 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6215 (20130101) Computational Chemistry; Chemoinformatics; Computational Materials Science G16C 60/00 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137112 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yilu LIU (Knoxville, Tennessee); Wenxuan YAO (Knoxville, Tennessee); He YIN (Knoxville, Tennessee); Wenpeng YU (Knoxville, Tennessee) |
| ABSTRACT | A method includes performing by a processor: determining a phase angle alignment parameter based on a ratio of a phase angle difference and a frequency difference, the phase angle difference comprising a difference between a first phase angle corresponding to a reference synchronized measurement device (SMD) and a second phase angle corresponding to a follower SMD, the frequency difference comprising a difference between a frequency at which the first and second phase angles are measured and a nominal frequency; receiving a first plurality of synchrophasor measurements of a power system signal from the reference SMD; receiving a second plurality of synchrophasor measurements of the power system signal from the follower SMD, the first plurality of synchrophasor measurements and the second plurality of synchrophasor measurements being offset in time relative to each other by a sampling time shift; and aligning phase angles of the second plurality of synchrophasor measurements with phase angles of the first plurality of synchrophasor measurements using the phase angle alignment parameter. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085526 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 25/04 (20130101) Original (OR) Class G01R 29/18 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/001 (20200101) H02J 2203/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137169 | ENGLUND |
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| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Dirk Robert ENGLUND (Brookline, Massachusetts) |
| ABSTRACT | Chemical-shift nuclear magnetic resonance (NMR) spectroscopy involves measuring the effects of chemical bonds in a sample on the resonance frequencies of nuclear spins in the sample. Applying a magnetic field to the sample causes the sample nuclei to emit alternating current magnetic fields that can be detected with color centers, which can act as very sensitive magnetometers. Cryogenically cooling the sample increases the sample's polarization, which in turn enhances the NMR signal strength, making it possible to detect net nuclear spins for very small samples. Flash-heating the sample or subjecting it to a magic-angle-spinning magnetic field (instead of a static magnetic field) eliminates built-in magnetic field inhomogeneities, improving measurement sensitivity without degrading the sample polarization. Tens to hundreds of small, cryogenically cooled sample chambers can be integrated in a semiconductor substrate interlaced with waveguides that contain color centers for optically detected magnetic resonance measurements of the samples' chemical-shift NMR frequencies. |
| FILED | Friday, September 03, 2021 |
| APPL NO | 17/465895 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/31 (20130101) G01R 33/46 (20130101) Original (OR) Class G01R 33/282 (20130101) G01R 33/323 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137386 | Weida et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DAYLIGHT SOLUTIONS, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miles James Weida (Poway, California); Timothy Day (Poway, California) |
| ABSTRACT | An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/579015 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/00 (20130101) G02B 21/0056 (20130101) Original (OR) Class G02B 21/0088 (20130101) G02B 21/088 (20130101) G02B 21/365 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137397 | Zou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| ASSIGNEE(S) | THE TEXAS A and M UNIVERSITY SYSTEM (College Station, Texas) |
| INVENTOR(S) | Jun Zou (College Station, Texas); Song Xu (College Station, Texas) |
| ABSTRACT | Methods are disclosed for manufacturing a Micro-ElectroMechanical Systems (MEMS) scanning mirror. In an embodiment, one method includes depositing a hinge material on a substrate and removing first and second portions of the substrate to form an outer frame, an inner frame, and a mirror plate in the substrate. First and second portions of the hinge material rotationally couple the outer frame to the inner frame and the inner frame to the mirror plate for rotation about first and second orthogonal axes of rotation. In another embodiment, a third portion of the substrate rotationally couples the inner frame to the mirror plate. In still another embodiment, an elastomer material is configured as a bending hinge that rotationally couples the outer frame to the inner frame. |
| FILED | Thursday, March 19, 2020 |
| APPL NO | 17/438601 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0018 (20130101) B81B 2201/042 (20130101) B81B 2203/01 (20130101) Optical Elements, Systems, or Apparatus G02B 26/0833 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137484 | MITTAL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sunil MITTAL (Rockville, Maryland); Mohammad HAFEZI (Washington, District of Columbia) |
| ABSTRACT | Examples of the present disclosure include the use of a topological system including an array of coupled ring resonators that exhibits topological edge states to generate frequency combs and temporal dissipative Kerr solitons. The topological edge states constitute a travelling-wave super-ring resonator causing generation of at least coherent nested optical frequency combs, and self-formation of nested temporal solitons that are robust against defects in the array at a mode efficiency exceeding 50%. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515757 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/3513 (20130101) Original (OR) Class G02F 1/3536 (20130101) G02F 2203/15 (20130101) G02F 2203/17 (20130101) G02F 2203/54 (20130101) G02F 2203/56 (20130101) Transmission H04B 10/506 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137808 | Krishnamurthy et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vinayak Raman Krishnamurthy (West Lafayette, Indiana); Cecil Piya (West Lafayette, Indiana); Karthik Ramani (West Lafayette, Indiana) |
| ABSTRACT | Some examples provides a set of frameworks, process and methods aimed at enabling the expression and exploration of free-form and parametric 3D shape designs enabled through natural interactions with a hand-held mobile device acting as a controller for 3D virtual objects. A reference plane in a virtual space generated by the location of the mobile device may be used to select a 3D virtual object intersected by the reference plane. Positioning of the mobile device may also be used to control a pointer in the virtual space. In an example, the orientation of the mobile device may be detected by an accelerometer or gyroscope. In example, the position of the mobile device may be detected by a position sensor. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/571651 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/017 (20130101) G06F 3/0346 (20130101) G06F 3/04845 (20130101) G06F 3/04883 (20130101) Original (OR) Class Image Data Processing or Generation, in General G06T 19/006 (20130101) G06T 19/20 (20130101) G06T 2219/2016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138368 | Gentry et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Russell Gentry (Atlanta, Georgia); Benjamin Tasistro-Hart (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment provides a method of predicting a geometry of a turbine blade, comprising: obtaining a point cloud of the turbine blade, the point cloud comprising a plurality of points corresponding to locations on an external contour of the turbine blade; generating an external mesh for the turbine blade based on point cloud; defining a reference axis along the length of the blade; generating a plurality of sampling planes along the length of the reference axis, each sampling plane being normal to the reference axis and having a shape defined by portions of the mesh intersecting the sampling plane; for each of the plurality of sampling planes, matching the sampling plane to an airfoil profile in a database of known airfoil profiles; and creating a geometrical representation of the turbine blade by placing the airfoils on the reference axis and connecting the perimeter of each of the airfoils. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 17/434588 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/17 (20200101) Original (OR) Class G06F 30/20 (20200101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138608 | Ramette et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Joshua Ramette (Cambridge, Massachusetts); Josiah Sinclair (Cambridge, Massachusetts); Vladan VULETIC (Cambridge, Massachusetts) |
| ABSTRACT | An all-to-all coupled, high-fidelity, error-correctable quantum computer can scale to hundreds of qubits within a single cavity of moderate cooperativity with existing neutral atom technology. This quantum processor can enact teleported gates among any pair of qubits using a local Rydberg interaction between each qubit and a separate network of atoms that distribute entanglement via a cavity mode. Small atomic ensembles at network nodes allow for ultrafast, nondestructive readout with high fidelity by substantially shifting the resonance of even a poor-quality cavity. Fast readout enables near-deterministic entanglement distribution among network atoms despite cavity losses as well as syndrome measurements of qubit atoms for error correction. |
| FILED | Monday, August 30, 2021 |
| APPL NO | 17/460385 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/30101 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138630 | Bagchi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Saurabh Bagchi (West Lafayette, Indiana); Nawanol Theera-Ampornpunt (West Lafayette, Indiana) |
| ABSTRACT | System and methods for predictive application streaming are provided. The system may execute an application and, concurrently, the system may while load data blocks not stored on the device using a construct of superblocks. The system may detect an access event caused by an application accessing a data block in a memory. The system may determine, in response to the access event, a superblock comprising a plurality of blocks that are historically accessed within the same execution time window as the block. The system may forecast, based on the superblock and a machine learning model, superblocks to be accessed by the application that are not stored in the memory. The system may download the superblocks from a remote endpoint accessible via a network. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516497 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 5/02 (20130101) G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138631 | Jaskie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Kristen Jaskie (Scottsdale, Arizona); Joshua Martin (Geneva, Illinois); Andreas Spanias (Tempe, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Kristen Jaskie (Scottsdale, Arizona); Joshua Martin (Geneva, Illinois); Andreas Spanias (Tempe, Arizona) |
| ABSTRACT | Various embodiments of a system and associated method for identifying and classifying faults in a photovoltaic array using relatively little labeled data are described herein. In particular, the system builds on existing PU classification techniques by addition of a feedback loop that enables classification of limited operational data of a photovoltaic array by expanding a plurality of features within the operational data based on a learned importance of each feature. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/517447 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220139254 | Ramani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karthik Ramani (West Lafayette, Indiana); Gaoping Huang (West Lafayette, Indiana); Alexander J. Quinn (West Lafayette, Indiana); Yuanzhi Cao (Redmond, Washington); Tianyi Wang (West Lafayette, Indiana); Xun Qian (West Lafayette, Indiana) |
| ABSTRACT | A machine task tutorial system is disclosed that utilizes augmented reality to enable an expert user to record a tutorial for a machine task that can be learned by different trainee users in an adaptive manner. The machine task tutorial system advantageously utilizes an adaptation model that focuses on spatial and bodily visual presence for machine task tutoring. The machine task tutorial system advantageously enables adaptive tutoring in the recorded-tutorial environment based on machine state and user activity recognition. The machine task tutorial system advantageously utilizes AR to provide tutorial recording, adaptive visualization, and state recognition. In this way, the machine task tutorial system supports more effective apprenticeship and training for machine tasks in workshops or factories. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/517949 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/00342 (20130101) G06K 9/3233 (20130101) Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) Image Data Processing or Generation, in General G06T 13/40 (20130101) G06T 19/006 (20130101) G06T 2210/36 (20130101) Educational or Demonstration Appliances; Appliances for Teaching, or Communicating With, the Blind, Deaf or Mute; Models; Planetaria; Globes; Maps; Diagrams G09B 5/02 (20130101) G09B 19/24 (20130101) G09B 19/0069 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220139639 | Thomas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| INVENTOR(S) | Jayan Thomas (Orlando, Florida); Deepak Pandey (Orlando, Florida); Kowsik Sambath Kumar (Orlando, Florida) |
| ABSTRACT | Energized composites include vertically aligned graphene on carbon fibers (VGCF). The VGCF enhances surface area available for charge storage, acts as templates for depositing other charge storing materials and provides stability for a minimum of 100,000 discharge cycles. The final storage device is in the order of high strength carbon fiber matrix with active material, glass fiber separator with polymer electrolyte and another carbon fiber matrix with active material. To achieve higher voltage or current, devices can be connected in series or parallel, respectively. The whole structure is made into a structural component by infusing epoxy resin. An alternating pattern of energy storage devices allows for the epoxy resin to seep through the whole structure and strongly bind them to make a monolith multifunctional composite. The high strength energized composites can power any electrical devices including electric vehicles, portable electronics, and space vehicles without any tradeoff between energy and structural integrity. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/518985 |
| CURRENT CPC | Propulsion of Electrically-propelled Vehicles; Supplying Electric Power for Auxiliary Equipment of Electrically-propelled Vehicles; Electrodynamic Brake Systems for Vehicles in General; Magnetic Suspension or Levitation for Vehicles; Monitoring Operating Variables of Electrically-propelled Vehicles; Electric Safety Devices for Electrically-propelled Vehicles B60L 50/40 (20190201) Capacitors; Capacitors, Rectifiers, Detectors, Switching Devices or Light-sensitive Devices, of the Electrolytic Type H01G 11/40 (20130101) Original (OR) Class H01G 11/44 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140463 | Schuster et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Schuster (Chicago, Illinois); Aziza Suleymanzade (Cambridge, Massachusetts); Jonathan Simon (Chicago, Illinois); Alexander Anferov (Chicago, Illinois) |
| ABSTRACT | A millimeter-wave resonator is produced by drilling a plurality of holes into a piece of metal. Each hole forms an evanescent tube having a lowest cutoff frequency. The holes spatially intersect to form a seamless three-dimensional cavity whose fundamental cavity mode has a resonant frequency that is less than the cutoff frequencies of all the evanescent tubes. Below cutoff, the fundamental cavity mode does not couple to the waveguide modes, and therefore has a high internal Q. Millimeter waves can be coupled into any of the tubes to excite an evanescent mode that couples to the fundamental cavity mode. The tubes also provide spatial and optical access for transporting atoms into the cavity, where they can be trapped while spatially overlapping the fundamental cavity mode. The piece of metal may be superconducting, allowing the resonator to be used in a cryogenic environment for quantum computing and information processing. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/452654 |
| CURRENT CPC | Waveguides; Resonators, Lines, or Other Devices of the Waveguide Type H01P 7/04 (20130101) Original (OR) Class H01P 11/008 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140607 | LIU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yilu LIU (Knoxville, Tennessee); Kaiqi SUN (Knoxville, Tennessee); Huangqing XIAO (Knoxville, Tennessee) |
| ABSTRACT | A high voltage direct current (HVDC) transmission system comprises a first terminal comprising a first voltage source converter (VSC) having a first and second VSC terminals and a first line commutated converter (LCC) having first and second LCC terminals; a second terminal comprising a second VSC having third and fourth VSC terminals and a second LCC having third and fourth LCC terminals; and a transmission line pair comprising a positive transmission line that couples the first VSC terminal and the first LCC terminal of the first VSC and the first LCC, respectively, to the third VSC terminal and the third LCC terminal of the second VSC and the second LCC, respectively, and a second positive line that couples the second VSC terminal and the second LCC terminal of the first VSC and the first LCC, respectively, to the fourth VSC terminal and the fourth LCC terminal of the second VSC and the second LCC, respectively. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085595 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/36 (20130101) Original (OR) Class Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 7/219 (20130101) H02M 7/521 (20130101) H02M 7/1626 (20130101) H02M 7/53871 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140648 | ALTARJAMI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ibrahim Abdullah S. ALTARJAMI (Knoxville, Tennessee); Evangelos FARANTATOS (Encino, California); Hossein HOOSHYAR (White Plains, New York); Yilu LIU (Knoxville, Tennessee); Mahendra PATEL (Phoenixville, Pennsylvania); Huangqing XIAO (Knoxville, Tennessee); Chengwen ZHANG (Knoxville, Tennessee); Yi ZHAO (Knoxville, Tennessee); Lin ZHU (Knoxville, Tennessee) |
| ABSTRACT | A method includes injecting a probe signal into a power system; receiving a measurement of an operational parameter of the power system responsive to injecting the probe signal into the power system; generating a transfer function model of the power system based on the measurement of the operational parameter of the power system and the probe signal; and updating at least one control parameter of a Wide Area Damping Controller (WADC) communicatively coupled to the power system based on the transfer function model. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085703 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 13/0001 (20200101) H02J 13/00016 (20200101) H02J 13/00026 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220141077 | PROTHERO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Astrapi Corporation (Dallas, Texas) |
| ASSIGNEE(S) | Astrapi Corporation (Dallas, Texas) |
| INVENTOR(S) | Jerrold PROTHERO (Delray Beach, Florida); James J. STERLING (Chambersburg, Pennsylvania) |
| ABSTRACT | Systems, devices, and methods of the present invention enhance data transmission through the use of polynomial symbol waveforms (PSW) and sets of PSWs corresponding to a symbol alphabet is here termed a PSW alphabet. Methods introduced here are based on modifying polynomial alphabet by changing the polynomial coefficients or roots of PSWs and/or shaping of the polynomial alphabet, such as by polynomial convolution, to produce a designed PSW alphabet including waveforms with improved characteristics for data transmission. |
| FILED | Monday, January 17, 2022 |
| APPL NO | 17/577082 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 27/363 (20130101) H04L 27/2639 (20130101) H04L 27/2647 (20130101) H04L 27/3405 (20130101) Original (OR) Class H04L 27/3494 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220141588 | LiKamWa et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Robert LiKamWa (Tempe, Arizona); Frank Wencheng Liu (Tempe, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert LiKamWa (Tempe, Arizona); Frank Wencheng Liu (Tempe, Arizona) |
| ABSTRACT | A system to output a cross-talk cancelled spatial audio signal to two speakers, including a user tracking module to provide a location and orientation of a head of a user, and a time-domain dynamic crosstalk cancellation module to receive a spatial audio signal, the location and orientation of the head of the user from the user tracking module, a location for each of the two speakers, and generate the time-domain crosstalk cancelled spatial audio signal based thereon. |
| FILED | Tuesday, February 25, 2020 |
| APPL NO | 17/433797 |
| CURRENT CPC | Electric Digital Data Processing G06F 3/165 (20130101) Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 3/14 (20130101) Original (OR) Class H04R 5/02 (20130101) H04R 5/04 (20130101) Stereophonic Systems H04S 1/007 (20130101) H04S 7/303 (20130101) H04S 2400/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220141821 | D'ORO et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Salvatore D'ORO (Allston, Massachusetts); Francesco RESTUCCIA (Boston, Massachusetts); Tommaso MELODIA (Newton, Massachusetts) |
| ABSTRACT | Methods and systems for allocating radio access network (RAN) spectrum resources among a plurality of mobile virtual network operators (MVNOs) of a network of base stations. The methods and systems include determining a slicing enforcement policy that assigns resource blocks (RBs) of frequency units and time slots of spectrum resources to each MVNO according to a slicing policy in which each MVNO is allocated an amount of the spectrum resources on at least one base station in a determined time span. The slicing enforcement policy minimizes overlap between each MVNO's set of RBs with another MVNO's set of RBs on a same base station, and interference between each MVNO's set of RBs with another MVNO's set of RBs on an interfering base station. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/424522 |
| CURRENT CPC | Wireless Communication Networks H04W 16/10 (20130101) H04W 16/14 (20130101) H04W 48/18 (20130101) H04W 72/0453 (20130101) Original (OR) Class H04W 84/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220132843 | Whitten et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | David G. Whitten (Albuquerque, New Mexico); Dylan Brown (Albuquerque, New Mexico); Jianzhong Yang (Albuquerque, New Mexico); Edward Strach (Albuquerque, New Mexico); Mohammed Khalil (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David G. Whitten (Albuquerque, New Mexico); Dylan Brown (Albuquerque, New Mexico); Jianzhong Yang (Albuquerque, New Mexico); Edward Strach (Albuquerque, New Mexico); Mohammed Khalil (Albuquerque, New Mexico) |
| ABSTRACT | The present disclosure provides an antimicrobial substrate including a substrate and a polythiophene polymer. The polythiophene polymer has a number of repeated monomer units from n is 5-14 or 30 to 120, a number average molecular weight (Mn) from 1,000 to 4,000 or 10,000 to 40,000; and a polydispersity index (PDI) from 1 to 1.3. The present disclosure also provides the polythiophene polymer and uses thereof. |
| FILED | Thursday, September 23, 2021 |
| APPL NO | 17/448635 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 25/34 (20130101) A01N 43/10 (20130101) Original (OR) Class A01N 43/50 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/18 (20130101) A61L 2300/404 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/126 (20130101) C08G 2261/143 (20130101) C08G 2261/149 (20130101) C08G 2261/224 (20130101) C08G 2261/3223 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220134291 | Bhave et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); All American Lithium LLC (Brawley, California) |
| ASSIGNEE(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); All American Lithium LLC (Brawley, California) |
| INVENTOR(S) | Ramesh R. Bhave (Knoxville, Tennessee); Stephen Harrison (Benicia, California); Bruce A. Moyer (Oak Ridge, Tennessee); M. Parans Paranthaman (Knoxville, Tennessee) |
| ABSTRACT | A lithium extraction composite comprising: (i) a porous support and (ii) particles of a lithium-selective sorbent material coated on at least one surface of the support, wherein the support has a planar membrane, fiber (or rod), or tubular shape. A method for extracting and recovering a lithium salt from an aqueous solution by use of the above-described composition is also described, the method comprising (a) flowing the aqueous source solution through a first zone or over a first surface of the lithium extraction composite to result in selective lithium intercalation in the lithium-selective sorbent material in the first zone or first surface; and (b) simultaneously recovering lithium salt extracted in step (a) from said lithium-selective sorbent material by flowing an aqueous stripping solution through a second zone or over a second surface of the lithium extraction composite in which lithium ions from the first zone or first surface diffuse. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/572773 |
| CURRENT CPC | Separation B01D 69/04 (20130101) B01D 69/08 (20130101) B01D 69/10 (20130101) B01D 69/12 (20130101) Original (OR) Class B01D 71/021 (20130101) B01D 71/024 (20130101) B01D 71/34 (20130101) B01D 2257/204 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 26/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220134316 | Chou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); STC.UNM (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanley Shihyao Chou (Albuquerque, New Mexico); Christopher Ryan Riley (Albuquerque, New Mexico); Abhaya Datye (Albuquerque, New Mexico); Andrew de la Riva (Albuquerque, New Mexico) |
| ABSTRACT | High surface area, high entropy oxides comprising multiple metal cations in a single-phase fluorite lattice material enables intrinsic catalytic activity without platinum group metals, tunable oxygen storage capacity, and thermal stability. These properties can be obtained through a facile sol-gel synthesis to provide a low-temperature route for production of phase-pure multi-cationic oxides. The resulting materials achieved significantly higher surface area and catalytic performance, taking advantage of all the properties endowed by the various cations in the composition. |
| FILED | Tuesday, November 03, 2020 |
| APPL NO | 17/087938 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 23/10 (20130101) B01J 23/34 (20130101) B01J 23/83 (20130101) Original (OR) Class B01J 35/1009 (20130101) B01J 37/04 (20130101) B01J 37/0018 (20130101) B01J 37/036 (20130101) B01J 37/088 (20130101) B01J 37/0236 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/50 (20170801) Compounds of the Metals Beryllium, Magnesium, Aluminium, Calcium, Strontium, Barium, Radium, Thorium, or of the Rare-earth Metals C01F 17/241 (20200101) Compounds Containing Metals Not Covered by Subclasses C01D or C01F C01G 45/1228 (20130101) C01G 49/0054 (20130101) Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/30 (20130101) C01P 2002/50 (20130101) C01P 2006/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220134435 | Scime et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luke R. Scime (Knoxville, Tennessee); Vincent C. Paquit (Knoxville, Tennessee); Desarae J. Goldsby (Knoxville, Tennessee); William H. Halsey (Knoxville, Tennessee); Chase B. Joslin (Knoxville, Tennessee); Michael D. Richardson (Knoxville, Tennessee); Derek C. Rose (Knoxville, Tennessee); Derek H. Siddel (Knoxville, Tennessee) |
| ABSTRACT | Detection and classification of anomalies for powder bed metal additive manufacturing. Anomalies, such as recoater blade impacts, binder deposition issues, spatter generation, and some porosities, are surface-visible at each layer of the building process. A multi-scaled parallel dynamic segmentation convolutional neural network architecture provides additive manufacturing machine and imaging system agnostic pixel-wise semantic segmentation of layer-wise powder bed image data. Learned knowledge is easily transferrable between different additive manufacturing machines. The anomaly detection can be conducted in real-time and provides accurate and generalizable results. |
| FILED | Tuesday, November 17, 2020 |
| APPL NO | 16/950484 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/80 (20210101) Original (OR) Class Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/153 (20170801) B29C 64/386 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Image Data Processing or Generation, in General G06T 3/4046 (20130101) G06T 3/4053 (20130101) G06T 7/0004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135409 | Schenkel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of The University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas Schenkel (San Francisco, California); Arun Persaud (El Cerrito, California); Edward Barnard (Berkeley, California) |
| ABSTRACT | This disclosure provides systems, methods, and apparatus related to color centers. In one aspect, a method includes providing diamond doped with a dopant. A heavy-ion is directed to the diamond that passes through the diamond. The heavy-ion forms a line of dopant-vacancy centers as it passes through the diamond. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/509241 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 20/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/28 (20170801) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/52 (20130101) C01P 2004/16 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/65 (20130101) Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 29/04 (20130101) C30B 33/04 (20130101) Optical Elements, Systems, or Apparatus G02B 1/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135443 | Lin |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | West Virginia University Board of Governors on behalf of West Virginia University (Morgantown, West Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lian-Shin Lin (Morgantown, West Virginia) |
| ABSTRACT | This invention provides processes for treating a mixture of produced water and blowdown water comprising introducing produced water (PW) into blowdown water (BD) for forming a PW-BD water mixture, softening the PW-BD water mixture, subjecting the PW-BD water mixture to activated carbon filtration and reverse osmosis membrane desalination. The process generates a product water and a brine by-product. |
| FILED | Friday, September 17, 2021 |
| APPL NO | 17/448004 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/001 (20130101) C02F 1/441 (20130101) Original (OR) Class C02F 1/4618 (20130101) C02F 5/02 (20130101) C02F 9/00 (20130101) C02F 2101/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135507 | Moore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | U.S. Department of Energy (Washington, District of Columbia) |
| ASSIGNEE(S) | U.S. Department of Energy (Washington, District of Columbia) |
| INVENTOR(S) | Cameron Moore (Los Alamos, New Mexico); Trideep Rajale (Los Alamos, New Mexico); Karthikeyan K. Ramasamy (Richland, Washington); Andrew Sutton (Los Alamos, New Mexico) |
| ABSTRACT | The invention relates to a two-way approach to isolate, recover and upgrade 2,3-Butanediol (2,3-BDO) from fermentation broth. A complete separation and recovery process for 2,3-BDO using acetalization and trans-acetalization sequence. Acetalization with butyraldehyde using heterogeneous catalysts, either Amberlyst-15® or Nafion NR50®, efficiently isolates 2,3-BDO as phase-separated protected dioxolane. The approach provides significant process advantages with easy product recovery and high recyclability of the catalyst. Trans-acetalization of dioxolane with methanol (methanolysis) followed by distillation of acetal, yielded very high purity 2,3-BDO with about 90% isolated yield. Alternatively, dioxolane is used in a process direct to methyl ethyl ketone (MEK) as a BDO synthon allowing for recovery of the aldehyde. |
| FILED | Tuesday, November 03, 2020 |
| APPL NO | 17/087841 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 29/92 (20130101) Original (OR) Class C07C 2521/12 (20130101) C07C 2531/025 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135623 | Williams et al. |
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| FUNDED BY |
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| APPLICANT(S) | TRIAD National Security, LLC. (Los Alamos, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert F. Williams (Los Alamos, New Mexico); David Owen Baumann (Los Alamos, New Mexico); John Cameron Gordon (Los Alamos, New Mexico) |
| ABSTRACT | The present disclosure provides peptoid-based chelating ligands, corresponding cyclic peptoids, and methods of making thereof. Functional groups may be tailored for high metal binding affinity and selectivity. The side chains of a cyclic peptoid according to the present disclosure may be selected based on, for example, high affinity for actinide or other metal ions, selectivity for actinide or other metal ions, the ability to recover a metal once it is bound to the peptoid, and whether the overall peptoid should be hydrophobic or hydrophilic. Unlike siderophores, peptoid-based chelating ligands of the present disclosure are not readily hydrolyzed under physiological conditions. Therefore, peptoid-based chelating ligands may be, for example, used to treat actinide (e.g., iron and lead) poisoning in vivo. Moreover, peptoid-based chelating ligands of the present disclosure may be used for medical imaging, chelation therapy, drug delivery, and separation technologies, for example. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576577 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/64 (20170801) A61K 49/0056 (20130101) Peptides C07K 7/54 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135892 | PATEL |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Nikhil Manubhai PATEL (Grand Forks, North Dakota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nikhil Manubhai PATEL (Grand Forks, North Dakota) |
| ABSTRACT | The present invention discloses a gasifier and/or a gasification process that provides a long, uniform temperature zone in the gasifier, regardless of the particle size, chemical composition, and moisture content of the fuel by sandwiching a reduction zones between two oxidation zones. The gasifier and/or gasification process has a char that is more energy-dense and almost devoid of moisture that affords for an additional (or char) oxidation zone with a temperature that is higher than a first oxidation zone which is closer to an evaporation and devolatilization zone. As such, the additional (or char) oxidation zone contributes to augmenting the reduction zone temperature, thereby providing a favorable dual impact in improving syngas composition and near-complete conversion of the tar. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570448 |
| CURRENT CPC | Production of Producer Gas, Water-gas, Synthesis Gas From Solid Carbonaceous Material, or Mixtures Containing These Gases; Carburetting Air or Other Gases C10J 3/08 (20130101) Original (OR) Class C10J 3/22 (20130101) C10J 3/26 (20130101) C10J 3/723 (20130101) C10J 2300/092 (20130101) C10J 2300/093 (20130101) C10J 2300/0946 (20130101) C10J 2300/0956 (20130101) C10J 2300/0959 (20130101) C10J 2300/0976 (20130101) C10J 2300/1246 (20130101) Purifying or Modifying the Chemical Composition of Combustible Gases Containing Carbon Monoxide C10K 1/024 (20130101) C10K 1/026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136016 | TRINH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| ASSIGNEE(S) | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, Tennessee) |
| INVENTOR(S) | Cong T. TRINH (Knoxville, Tennessee); Hyeongmin SEO (Elkton, Maryland); Jong-Won LEE (Knoxville, Tennessee) |
| ABSTRACT | A modified chloramphenicol acetyltransferase comprising a tyrosine residue 20 having a phenylalanine (Y20F) mutation, a microorganism harboring the modified chloramphenicol acetyltransferase, and a method of producing ester by feeding the microorganism are disclosed. The method includes providing the microorganism harboring a modified chloramphenicol acetyltransferase in an environment suitable for the microorganism to produce an ester and feeding the microorganism (i) a sugar or a cellulose, and (ii) an alcohol and/or a carboxylic acid. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/453306 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/1033 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/62 (20130101) Original (OR) Class Enzymes C12Y 203/01028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136119 | Flanders et al. |
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| FUNDED BY |
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| APPLICANT(S) | Opus 12 Incorporated (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas H. Flanders (San Francisco, California); Kendra P. Kuhl (Oakland, California); Etosha R. Cave (Berkeley, California); Sichao Ma (Dublin, California); Ziyang Huo (Moraga, California); Carter S. Haines (Berkeley, California); Timothy A. Bekkedahl (Sunnyvale, California); Kathryn L. Corp (Berkeley, California); Ashley D. Mishra (Danville, California); Edward Izett (Berkeley, California) |
| ABSTRACT | A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition. |
| FILED | Tuesday, August 03, 2021 |
| APPL NO | 17/444356 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/08 (20130101) B01J 20/10 (20130101) B01J 20/20 (20130101) B01J 20/3483 (20130101) B01J 2220/42 (20130101) Apparatus for Enzymology or Microbiology; C12M 43/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 5/023 (20130101) C12P 7/06 (20130101) C12P 7/16 (20130101) C12P 7/52 (20130101) C12P 7/54 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/03 (20210101) C25B 3/26 (20210101) C25B 13/08 (20130101) C25B 15/081 (20210101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136133 | SINGH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE UNIVERSITY OF CHICAGO (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Manish SINGH (Chicago, Illinois); Tian ZHONG (Chicago, Illinois); Supratik GUHA (Chicago, Illinois) |
| ABSTRACT | The present disclosure includes a thin film assembly comprising a substrate and an epitaxial crystalline thin film disposed on the substrate, wherein the epitaxial crystalline thin film is a single crystal, wherein at least a portion of the epitaxial crystalline thin film is doped with rare-earth ions at a concentration of less than 100 parts per billion. The disclosure further includes a method of manufacturing a thin film assembly, the method comprising creating, on a substrate and with use of molecular beam epitaxy, an epitaxial crystalline thin film doped with the rare-earth ions at a concentration of less than 100 parts per billion. |
| FILED | Thursday, March 05, 2020 |
| APPL NO | 17/434221 |
| CURRENT CPC | Single-crystal-growth; Unidirectional Solidification of Eutectic Material or Unidirectional Demixing of Eutectoid Material; Refining by Zone-melting of Material; Production of a Homogeneous Polycrystalline Material With Defined Structure; Single Crystals or Homogeneous Polycrystalline Material With Defined Structure; After-treatment of Single Crystals or a Homogeneous Polycrystalline Material With Defined Structure; Apparatus Therefor C30B 23/02 (20130101) Original (OR) Class C30B 29/16 (20130101) C30B 29/32 (20130101) C30B 33/08 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 10/126 (20130101) H01F 41/302 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136735 | RENDALL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | JOSEPH D. RENDALL (Oak Ridge, Tennessee); KYLE R. GLUESENKAMP (Knoxville, Tennessee); ANTHONY C. GEHL (Knoxville, Tennessee); JERALD A. ATCHLEY (Oak Ridge, Tennessee) |
| ABSTRACT | A diffuser for a water heater fill tubes having a tube wall with an outside diameter. The diffuser includes an elongated flexible diffuser body for positioning at the outlet end of the fill tube. The diffuser body has a sealing end for sealing with an outside surface of the fill tube wall closest to the inlet end of the fill tube, and an open end for positioning at an end closest to the outlet end of the fill tube. The open end has a diameter larger than an outside diameter of the tube wall, thereby creating an diffuser water outlet opening between the diffuser body and the tube wall for redirecting radial water flow emanating from the fill tube water outlet opening(s) toward the diffuser outlet opening. A fill tube assembly for a water heater, a water heater, and a method for heating water are also disclosed. |
| FILED | Friday, March 05, 2021 |
| APPL NO | 17/193344 |
| CURRENT CPC | Fluid Heaters, e.g Water or Air Heaters, Having Heat Generating Means, in General F24H 1/186 (20130101) F24H 9/0015 (20130101) Original (OR) Class F24H 9/124 (20130101) F24H 9/2035 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136943 | Busenitz et al. |
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| FUNDED BY |
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| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas City, Missouri) |
| INVENTOR(S) | Clark Busenitz (Overland Park, Kansas); Weston A. McGuire (Overland Park, Kansas) |
| ABSTRACT | An assembly for shock testing a specimen, the assembly including first and second opposing brackets and opposing lower and upper caps. The opposing brackets include lower and upper angled surfaces. The lower cap includes lower angled surfaces configured to engage the lower angled surfaces of the left and right brackets. The upper cap includes upper angled surfaces configured to engage the upper angled surfaces of the left and right brackets. The first and second brackets are configured to be drawn toward each other via fasteners, thereby wedging the lower and upper caps toward each other against the specimen. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/571583 |
| CURRENT CPC | Testing Static or Dynamic Balance of Machines or Structures; Testing of Structures or Apparatus, Not Otherwise Provided for G01M 7/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/04 (20130101) Original (OR) Class G01N 3/30 (20130101) G01N 2203/026 (20130101) G01N 2203/0256 (20130101) G01N 2203/0405 (20130101) G01N 2203/0482 (20130101) G01N 2203/0676 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136999 | Garimella et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Venkata BS Garimella (Richland, Washington); Ahmed M. Hamid (Richland, Washington); Yehia M. Ibrahim (West Richland, Washington); Richard D. Smith (Richland, None) |
| ABSTRACT | Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557690 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/624 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 49/26 (20130101) H01J 49/0027 (20130101) H01J 49/062 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137452 | DUOSS et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric B. DUOSS (Danville, California); James OAKDALE (Castro Valley, California); Nicholas Anthony RODRIGUEZ (Austin, Texas); Hongtao SONG (Austin, Texas); Richard CRAWFORD (Austin, Texas); Carolyn SEEPERSAD (Austin, Texas); Morgan CHEN (Richardson, Texas) |
| ABSTRACT | The present disclosure relates to a liquid crystal display (LCD) system. The system in one example has a light source for generating unpolarized light, and an LCD screen arranged in a path of transmittance of the unpolarized light. First and second wire grid polarizers are arranged adjacent to the LCD screen and each have a plurality of nano-scale wires, with the first and second wire grid polarizers have differing polarizations. A pitch of each of the nano-scale wires is no larger than one-third a wavelength of the unpolarized light from the light source. The wire grid polarizers create, in connection with operation of the LCD screen, a 2D light mask suitable for initiating the polymerization of an optically curable material. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/085244 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/286 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/133512 (20130101) G02F 1/133528 (20130101) Original (OR) Class G02F 1/133603 (20130101) G02F 2001/133531 (20130101) G02F 2001/133548 (20130101) G02F 2202/36 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138611 | Siddiqi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Irfan Siddiqi (Berkeley, California); Jie Luo (Berkeley, California); Brian Marinelli (Berkeley, California) |
| ABSTRACT | A superconducting quantum processor unit for quantum computing is provided. The processor unit is formed from the union of a qubit chip and a wiring chip with superconducting bonding bumps and spacers. The bumps may be densely distributed around active elements between the two chips and effectively form a Faraday-Cage around the qubits, control signal waveguides etc. The qubit chip has strategically spaced qubits and an inductively coupled probe line and the wiring chip has a bus coupling resonator with a number of voltage nodes and anti-nodes, a resonator pump and at least one SQUID. Magnetic flux applied through the SQUIDs changes their impedances and modifies the microwave boundary conditions of the bus. This allows in-situ shifting of electric field distributions of the resonance modes of the bus along the length of the bus. This tunes the coupling rates of the bus to all qubits simultaneously. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/519320 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/0358 (20130101) Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138872 | Vaagensmith et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Energy Alliance, LLC (Idaho Falls, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bjorn C. Vaagensmith (Idaho Falls, Idaho); Jesse L. Reeves (Ammon, Idaho); James R. Case (Ammon, Idaho); Timothy R. McJunkin (Idaho Falls, Idaho); Kurt G. Vedros (Ammon, Idaho); Liam D. Boire (Idaho Falls, Idaho); Jason A. Wayment (Idaho Falls, Idaho); Craig G. Rieger (Pocatello, Idaho) |
| ABSTRACT | Described are systems, methods and devices for computer-aided infrastructure assessment. Some embodiments relate to computer-aided assessment of infrastructure using combinations of probabilistic risk assessment, resource delivery simulation, and physics-based resilience analysis. |
| FILED | Tuesday, August 20, 2019 |
| APPL NO | 17/269448 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/0635 (20130101) G06Q 50/06 (20130101) Original (OR) Class Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/00 (20130101) H02J 2203/20 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220139579 | ALESHIN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Yuriy ALESHIN (Cayce, South Carolina); Alex LEVINSKY (Pittsburgh, Pennsylvania) |
| ABSTRACT | An adjustable core assembly for a nuclear reactor is disclosed herein. The adjustable core can include a plurality of reactivity control cells configured to accommodate a reactivity control rod, and a plurality of unit cells. The plurality of unit cells defines a radial dimension corresponding to an initial power output of the core. Each unit cell of the plurality of unit cells is configured to accommodate fuel configured to generate energy and a heat pipe configured to transfer thermal energy away from the core. Each unit cell of the plurality unit cells can be coupled to an adjacent unit cell in a radial direction, thereby altering the radial dimension, wherein the altered radial dimension corresponds to an adjusted power output of the core, and wherein the adjusted power output of the core is different than the initial power output of the core. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/084365 |
| CURRENT CPC | Nuclear Reactors G21C 7/36 (20130101) G21C 7/103 (20130101) Original (OR) Class G21C 15/257 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220139582 | LEVINSKY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| ASSIGNEE(S) | Westinghouse Electric Company LLC (Cranberry Township, Pennsylvania) |
| INVENTOR(S) | Alex LEVINSKY (Pittsburgh, Pennsylvania); Yuriy ALESHIN (Cayce, South Carolina); Alexander W. HARKNESS (Allison Park, Pennsylvania) |
| ABSTRACT | A configurable unit cell of a core of a nuclear reactor is disclosed herein. The configurable unit cell includes a core block material and a plurality of interchangeable components configured to affect a performance parameter of the core of the nuclear reactor. The configurable unit cell further includes a plurality of channels defined within the core block material. Each channel of the plurality of channels is configured to engage an interchangeable component of the plurality of interchangeable components in an operating configuration. Each channel of the plurality of channels is separated from an adjacent channel of the plurality of channels by a predetermined pitch. |
| FILED | Thursday, October 29, 2020 |
| APPL NO | 17/084403 |
| CURRENT CPC | Nuclear Reactors G21C 19/205 (20130101) Original (OR) Class Nuclear Power Plant G21D 3/002 (20190101) G21D 3/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140161 | STRADINS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pauls STRADINS (Golden, Colorado); William Michael NEMETH (Wheat Ridge, Colorado); David Levi YOUNG (Golden, Colorado); Caroline Lima Salles de SOUZA (Golden, Colorado) |
| ABSTRACT | The present disclosure relates to a passivating contact that includes a dielectric layer constructed of a first material, an intervening layer constructed of a second material, and a substrate constructed of a semiconductor, where the dielectric layer is positioned between the substrate and the intervening layer, the dielectric layer has a first thickness, and the substrate has a second thickness. The passivating contact also includes a plurality of conductive pathways that include the second material and pass through the first thickness, the second material penetrates into the second thickness forming a plurality of penetrating regions within the substrate, and the plurality of conductive pathways are configured to allow current to pass through the first thickness. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516533 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/456 (20130101) H01L 31/1868 (20130101) H01L 31/022441 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140601 | Vyakaranam et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Bharat GNVSR Vyakaranam (Redmond, Washington); Tony B. Nguyen (Richland, Washington); Quan H. Nguyen (Richland, Washington); Nader A. Samaan (Richland, Washington); Mallikarjuna R. Vallem (Richland, Washington); Renke Huang (Richland, Washington) |
| ABSTRACT | A computer-implemented method includes extending simulation results and input data of a DC production cost model (PCM) of a power grid to an initial AC power flow model (PFM) using a generation distribution mapping and load distribution mapping of a related PFM base example associated with the PCM, and automatically producing a chronological series of converged AC PFM solutions associated with a PCM time series by, for each time step of the PCM time series: (i) updating inputs of an AC PFM using (a) PCM results of the current time step and (b) solution outputs of a converged AC PFM obtained from a previous PCM time step, and (ii) iteratively, reducing nodal loads by a gradual amount configured to account for power grid power flow losses unaccounted for by the PCM and performing AC PFM numerical analyses, until: (a) an AC PFM convergence is obtained and (b) a real power generation slack bus is less than or equal to a predefined tolerance in relation to a slack bus of the PCM results of the current time step. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518478 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 3/003 (20200101) Original (OR) Class H02J 3/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140700 | Joshi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yogendra K. Joshi (Atlanta, Georgia); Wenming Li (Atlanta, Georgia) |
| ABSTRACT | A cooling system for an electric motor that includes a stator having a plurality of slot windings and a rotor, coaxial with the stator, having a plurality of magnets, includes a coolant inlet to the motor and a coolant outlet from the motor. A coolant pathway is in fluid communication with the inlet and the outlet. Heat is transferable from the slot windings to the coolant pathway. A coolant flows through the coolant pathway and is in a liquid phase as it enters the coolant inlet, changing into a gaseous phase as heat is transferred to the coolant from the slot windings. A cooling loop is in fluid communication with the coolant inlet and the coolant outlet. The cooling loop cools the coolant so that substantially all of the coolant is in the liquid phase when it enters the coolant inlet. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556403 |
| CURRENT CPC | Dynamo-electric Machines H02K 3/24 (20130101) H02K 5/203 (20210101) H02K 9/197 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140712 | Sudhoff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Scott Sudhoff (West Lafayette, Indiana); Jiazhou Zhong (West Lafayette, Indiana); Steve Pekarek (West Lafayette, Indiana) |
| ABSTRACT | A homopolar alternating current machine (HAM) is disclosed which includes a stator having a plurality of segments radially protruding outward, each segment includes a main winding, a first auxiliary winding, and a second auxiliary winding, whereby each of the first and second auxiliary windings are coupled to each other in a parallel manner, a first rotor disposed proximate the stator, a second rotor disposed proximate the stator, and a dc flux source corresponding to each of the first and second rotors, whereby substantially no excitation of the first and the second auxiliary windings of each stator segment of the plurality of segments is needed to operate the HAM, whereby when energized, there is substantially no DC flux in each of the main winding, wherein operating the HAM results in a substantially sinusoidal current waveform without a DC offset, and wherein the HAM can be operated as a motor or generator. |
| FILED | Saturday, October 30, 2021 |
| APPL NO | 17/515460 |
| CURRENT CPC | Dynamo-electric Machines H02K 1/148 (20130101) H02K 3/28 (20130101) H02K 19/18 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220134655 | Townsend et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sidus Space, Inc. (Merritt Island, Florida) |
| ASSIGNEE(S) | Sidus Space, Inc. (Merritt Island, Florida) |
| INVENTOR(S) | Ivan Townsend (Kennedy Space Center, Florida); Robert Mueller (Kennedy Space Center, Florida); Nathan Gelino (Kennedy Space Center, Florida); Jonathan Smith (Kennedy Space Center, Florida); Matthew Nugent (Kennedy Space Center, Florida); Andrew Nick (Kennedy Space Center, Florida); Jason Schuler (Kennedy Space Center, Florida); Bradley Buckles (Kennedy Space Center, Florida) |
| ABSTRACT | A three-dimensional print head apparatus may include a securing mechanism, a hopper, a nozzle, a heating system, and a fume extraction system. The securing mechanism may be adapted to secure to a wrist joint of a robotic arm. The hopper may have a cavity and a lower aperture and may be secured to the securing mechanism. The nozzle may have an upper aperture and a lower aperture. The heating system may be positioned along the barrel. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/648044 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/209 (20170801) Original (OR) Class B29C 64/329 (20170801) B29C 64/364 (20170801) B29C 64/393 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 30/00 (20141201) B33Y 50/02 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135412 | Waterman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Vermont and State Agricultural College (Burlington, Vermont) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rory Waterman (Burlington, Vermont); Brandon Ackley (Burlington, Vermont) |
| ABSTRACT | Methods of making a ceramic of a Group 13-15 type or a Group 13-15-16 type by thermolyzing a discrete molecular precursor to the ceramic in an oxygen-containing atmosphere. In some embodiments, the discrete molecular precursor is bench-stable and comprises a Lewis acid-base pair or small cyclic compound containing at last one Group 13 element and at least one Group 15 element but does not include indium and phosphorus in combination with one another unless a Group 16 element is present. The thermolysis can be carried out in air, at atmospheric pressure, and at a temperature below about 400° C., if desired. In some embodiments, the discrete molecular precursor can be placed in a mold having a desired shape and the thermolysis performed while the discrete molecular precursor is in the mold so as to produce a ceramic product having the desired shape. |
| FILED | Tuesday, February 11, 2020 |
| APPL NO | 17/433276 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 25/087 (20130101) C01B 35/04 (20130101) C01B 35/14 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2002/88 (20130101) C01P 2004/03 (20130101) C01P 2006/40 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135925 | Reiserer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | VANDERBILT UNIVERSITY (Nashville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ronald S. Reiserer (Nashville, Tennessee); Gregory B. Gerken (Nashville, Tennessee); David K. Schaffer (Nashville, Tennessee); John P. Wikswo (Brentwood, Tennessee) |
| ABSTRACT | A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/578966 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/08 (20130101) C12M 23/10 (20130101) C12M 23/12 (20130101) C12M 23/16 (20130101) C12M 23/50 (20130101) C12M 23/58 (20130101) C12M 27/02 (20130101) C12M 27/12 (20130101) C12M 29/10 (20130101) Original (OR) Class C12M 35/02 (20130101) C12M 35/04 (20130101) C12M 41/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136779 | Chen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Weibo Chen (Pasadena, California); Benjamin I. Furst (Pasadena, California); Scott N. Roberts (Altadena, California) |
| ABSTRACT | Systems and methods for thermal management using separable heat pipes and methods of manufacture thereof. Various embodiments provide a porous insert that can be used to join or connect heat pipes. Further embodiments provide thermal management systems that are modular, expandable, reparable, by allowing for joining of evaporators, condensers, and adiabatic sections via porous inserts. Various embodiments allow for two-phase thermal management systems, where liquid and gaseous phases can be transported simultaneously. Certain embodiments incorporate heat generating components with embedded evaporators and/or condensers. Many embodiments are additively manufactured, including via 3D printing. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/453332 |
| CURRENT CPC | Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/04 (20130101) F28D 15/0241 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136950 | Miller-Lionberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Colorado State University Research Foundation (Frort Collins, Colorado); Access Sensor Technologies LLC (Frort Collins, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel D. Miller-Lionberg (Denver, Colorado); Casey W. Quinn (Olympia, Washington); Christian C. L'Orange (Fort Collins, Colorado); Jeffrey R. Pierce (Fort Collins, Colorado); Eric A. Wendt (Fort Collins, Colorado); John Volckens (Fort Collins, Colorado) |
| ABSTRACT | In certain embodiments, a portable atmospheric monitor comprises a housing at least partially enclosing an inner chamber. The housing comprises an inlet and an aperture. The monitor also includes at least one light sensor arranged within the housing. The light sensor that senses one or more wavelengths of sunlight received via the aperture. The monitor includes at least one light-scattering sensor that senses PM received via the inlet. The monitor includes a processor arranged within the housing and coupled to the at least one light sensor and the at least one light-scattering sensor. The processor is configured to: receive a light signal from the at least one light sensor; receive a PM signal from the at least one light-scattering sensor; determine the aerosol optical depth based upon the light signal; and determine the PM concentration based upon the PM signal. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 17/602147 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/06 (20130101) Original (OR) Class G01N 21/53 (20130101) G01N 2001/2223 (20130101) Geophysics; Gravitational Measurements; Detecting Masses or Objects; Tags G01V 8/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140494 | Freebury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TENDEG LLC (Louisville, Colorado) |
| ASSIGNEE(S) | TENDEG LLC (Louisville, Colorado) |
| INVENTOR(S) | Gregg E. Freebury (Louisville, Colorado); Matthew Phillip Mitchell (Colorado Springs, Colorado) |
| ABSTRACT | An antenna having a reflector mounted on a rigid boom uses a line feed or phased array feed to operate in the Ka band with frequencies up to 36 gigahertz while maintaining the ability to operate at frequencies down to L-Band of 1-2 GHz. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571115 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 15/14 (20130101) Original (OR) Class H01Q 15/141 (20130101) H01Q 15/147 (20130101) H01Q 15/161 (20130101) H01Q 15/162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220136986 | Motes, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Texas Research International, Inc. (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Doyle T. Motes, III (Austin, Texas); Marcus Keiser (Cedar Park, Texas); Richard Piner (Austin, Texas) |
| ABSTRACT | Non-destructive sensing methods and devices for inspection and measuring in manufacturing applications for removal of contaminants from composite surfaces coupled with sensing and activation of the composite surfaces. |
| FILED | Friday, September 10, 2021 |
| APPL NO | 17/472533 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 23/225 (20130101) G01N 23/2202 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137386 | Weida et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DAYLIGHT SOLUTIONS, INC. (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Miles James Weida (Poway, California); Timothy Day (Poway, California) |
| ABSTRACT | An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays. |
| FILED | Wednesday, January 19, 2022 |
| APPL NO | 17/579015 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 21/00 (20130101) G02B 21/0056 (20130101) Original (OR) Class G02B 21/0088 (20130101) G02B 21/088 (20130101) G02B 21/365 (20130101) Pictorial Communication, e.g Television H04N 5/33 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220139031 | Young et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRX Systems, Inc. (Greenbelt, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Travis Young (Rockville, Maryland); Daniel Hakim (Silver Spring, Maryland); Daniel Franchy (Catonsville, Maryland); Jared Napora (Severn, Maryland); John Karvounis (Bowie, Maryland); Jonathan Fetter Degges (Washington, District of Columbia); Tim Wang (Germantown, Maryland); Benjamin Funk (Hanover, Maryland); Carole Teolis (Glendale, Maryland); Carol Politi (Bethesda, Maryland); Stuart Woodbury (Ellicott City, Maryland) |
| ABSTRACT | Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device. |
| FILED | Wednesday, September 15, 2021 |
| APPL NO | 17/475935 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/13 (20200101) Image Data Processing or Generation, in General G06T 17/05 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220140494 | Freebury et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TENDEG LLC (Louisville, Colorado) |
| ASSIGNEE(S) | TENDEG LLC (Louisville, Colorado) |
| INVENTOR(S) | Gregg E. Freebury (Louisville, Colorado); Matthew Phillip Mitchell (Colorado Springs, Colorado) |
| ABSTRACT | An antenna having a reflector mounted on a rigid boom uses a line feed or phased array feed to operate in the Ka band with frequencies up to 36 gigahertz while maintaining the ability to operate at frequencies down to L-Band of 1-2 GHz. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571115 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 15/14 (20130101) Original (OR) Class H01Q 15/141 (20130101) H01Q 15/147 (20130101) H01Q 15/161 (20130101) H01Q 15/162 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220134579 | CAO et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Changyong CAO (Okemos, Michigan); Xiaobo TAN (Okemos, Michigan); Yaokun PANG (East Lansing, Michigan); Shoue CHEN (East Lansing, Michigan) |
| ABSTRACT | A soft gripper apparatus is provided. In another aspect, a soft gripper includes tribo-skin pressure sensors, an internal bending sensor, at least one flexible gripping finger and an actuator. A further aspect of a soft gripper apparatus employs longitudinally elongated, laterally spaced apart and self-powering, electrically conductive strips that sense and send a bending signal to a programmable controller indicative of a bending angle of a gripping finger within which the strips are encapsulated. Another aspect of a gripping apparatus includes at least one workpiece pressure sensor and/or at least one bending sensor, which are connected to a programmable controller and electrical circuit to automatically determine a characteristic of the workpiece. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/515628 |
| CURRENT CPC | Manipulators; Chambers Provided With Manipulation Devices B25J 13/081 (20130101) B25J 13/087 (20130101) B25J 15/10 (20130101) B25J 15/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220135902 | CERMAK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as Represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | STEVEN C. CERMAK (GALESBURG, Illinois); TERRY ISBELL (ELMWOOD, Illinois); BENJAMIN A. LOWERY (PRINCEVILLE, Illinois) |
| ABSTRACT | The invention relates to methods for the synthesis of hydroxy fatty acids from unsaturated fatty acids via epoxidation and catalytic hydrogenation. |
| FILED | Thursday, November 04, 2021 |
| APPL NO | 17/519162 |
| CURRENT CPC | Fatty Acids From Fats, Oils or Waxes; Candles; Fats, Oils or Fatty Acids by Chemical Modification of Fats, Oils, or Fatty Acids Obtained Therefrom C11C 3/126 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138219 | Beckham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Tammy Beckham (Manhattan, Kansas); Matthew Coats (Washington, District of Columbia); John Korslund (Riverdale, Maryland); Michelle Colby (Washington, District of Columbia); James Wall (College Station, Texas); Keith Biggers (College Station, Texas); Melissa Berquist (College Station, Texas); Austin Riddle (College Station, Texas); Paul Bilnoski (College Station, Texas); Derek Overby (Covington, Louisiana); Graham Booker (College Station, Texas); Lindsey Holmstrom (Manhattan, Kansas) |
| ABSTRACT | A system and computerized method for monitoring and analyzing animal related data. In one embodiment, the system includes a processor and memory operable to identify a parameter related to animal management for species in a biological environment, aggregate animal related data from different sources about the parameter of the species, identify a baseline for the parameter, correlate the animal related data against the baseline to obtain correlated data, and analyze said correlated data to assess said animal management. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571393 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 11/008 (20130101) A01K 29/005 (20130101) Electric Digital Data Processing G06F 3/04847 (20130101) G06F 16/26 (20190101) Original (OR) Class G06F 16/29 (20190101) G06F 40/106 (20200101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/10 (20130101) G06Q 50/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220134331 | Esch |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mandy Brigitte Esch (Gaithersburg, Maryland) |
| ABSTRACT | A gravity flow micro-physiological article determines a physiological response to a drug and includes: supply chambers; a mixing chamber; and a liquid divider, wherein the divider divides fluid under gravitational force so that individual portions of the fluid independently include metabolites in a proportionate amount as physically determined by the liquid divider. |
| FILED | Friday, October 29, 2021 |
| APPL NO | 17/513942 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/50273 (20130101) Original (OR) Class B01L 3/502715 (20130101) B01L 2400/0457 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5038 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136106 | Oh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Il-Kwon Oh (Suwon, South Korea); Stacey F. Bent (Stanford, California) |
| ABSTRACT | Advanced precursors for selective atomic layer deposition (ALD) of aluminum oxide (Al2O3) using self-assembled monolayers (SAM) are provided. Area selective atomic layer deposition (AS-ALD) is a highly sought-after strategy for the fabrication of next-generation electronics. Embodiments described herein provide a process of selective ALD of Al2O3 that achieves an excellent selectivity between an SAM-coated surface and non-coated surface by adopting one of several novel ALD precursors. Some embodiments further optimize process parameters (e.g., growth temperature, precursor partial pressure, precursor dosing time, purging time, reactant dosing time, and number of cycles) to further improve selectivity of the ALD precursor. |
| FILED | Monday, November 01, 2021 |
| APPL NO | 17/516139 |
| CURRENT CPC | Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 16/403 (20130101) C23C 16/45553 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/0228 (20130101) H01L 21/02178 (20130101) H01L 21/02205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136967 | Obeng |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yaw Samuel Obeng (Frederick, Maryland) |
| ABSTRACT | Embodiments of the present invention relate to a system and method for detecting biological material on surfaces after decontamination with UV-C and with high sensitivity and having low detection limits while providing rapid and efficient response to accommodate high turnover. Embodiments of the present invention monitor the disinfection process by detecting changes in the electrical properties of surface-confined biological thin films photodegraded with UV-C radiation using microwaves (MW). MW sensing provides noninvasive, real-time detection of the electromagnetic properties of biological materials via concentrated electromagnetic fields, for which advantages include wide bandwidth, small size, and cost-effective fabrication. |
| FILED | Friday, November 05, 2021 |
| APPL NO | 17/520116 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/28 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/47 (20130101) Original (OR) Class G01N 22/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220134146 | Thompson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of The United States of America, as represented by the Secretary of Homeland Security (Wahsington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | William G. Thompson (Elizabeth City, North Carolina); Mary Shalane Regan (Groton, Connecticut) |
| ABSTRACT | A cover device for a regulator, which has a purge button and a mouthpiece connected to the regulator, includes a body having a mouthpiece housing to receive the mouthpiece through an access opening which presents a friction fit to squeeze the mouthpiece passing therethrough in a squeezed state to enter and exit a hollow interior of the mouthpiece housing. The hollow interior is configured to store the mouthpiece in a relaxed state. A button cover is connected to the mouthpiece housing to cover the purge button on a top surface of the regulator when the mouthpiece is inserted into the hollow interior of the mouthpiece housing. The button cover is narrower in width than the mouthpiece housing. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/541100 |
| CURRENT CPC | Devices, Apparatus or Methods for Life-saving A62B 9/06 (20130101) A62B 25/00 (20130101) Original (OR) Class Launching, Hauling-out, or Dry-docking of Vessels; Life-saving in Water; Equipment for Dwelling or Working Under Water; Means for Salvaging or Searching for Underwater Objects B63C 11/186 (20130101) B63C 11/2227 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138219 | Beckham et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Tammy Beckham (Manhattan, Kansas); Matthew Coats (Washington, District of Columbia); John Korslund (Riverdale, Maryland); Michelle Colby (Washington, District of Columbia); James Wall (College Station, Texas); Keith Biggers (College Station, Texas); Melissa Berquist (College Station, Texas); Austin Riddle (College Station, Texas); Paul Bilnoski (College Station, Texas); Derek Overby (Covington, Louisiana); Graham Booker (College Station, Texas); Lindsey Holmstrom (Manhattan, Kansas) |
| ABSTRACT | A system and computerized method for monitoring and analyzing animal related data. In one embodiment, the system includes a processor and memory operable to identify a parameter related to animal management for species in a biological environment, aggregate animal related data from different sources about the parameter of the species, identify a baseline for the parameter, correlate the animal related data against the baseline to obtain correlated data, and analyze said correlated data to assess said animal management. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/571393 |
| CURRENT CPC | Animal Husbandry; Care of Birds, Fishes, Insects; Fishing; Rearing or Breeding Animals, Not Otherwise Provided For; New Breeds of Animals A01K 11/008 (20130101) A01K 29/005 (20130101) Electric Digital Data Processing G06F 3/04847 (20130101) G06F 16/26 (20190101) Original (OR) Class G06F 16/29 (20190101) G06F 40/106 (20200101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/10 (20130101) G06Q 50/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220133957 | Boden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Emory University (Atlanta, Georgia); The United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott D. Boden (Atlanta, Georgia); Steven M. Presciutti (Decatur, Georgia); Sreedhara Sangadala (Marietta, Georgia) |
| ABSTRACT | This disclosure relates to sclerostin inhibitors for use in ossification, and methods related thereto. In certain embodiments, the disclosure relates to placing sclerostin inhibitors in graft compositions for forming bone. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a graft composition disclosed herein optionally comprising a growth factor such as BMP or recombinant vector expressing the same in a subject such as at a desired site of bone or cartilage growth. |
| FILED | Tuesday, February 04, 2020 |
| APPL NO | 17/428556 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/19 (20130101) A61K 31/506 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/24 (20130101) A61L 27/52 (20130101) A61L 27/54 (20130101) Original (OR) Class A61L 27/227 (20130101) A61L 2300/21 (20130101) A61L 2300/204 (20130101) A61L 2300/252 (20130101) A61L 2300/414 (20130101) A61L 2430/02 (20130101) A61L 2430/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220136059 | Czyzyk-Krzeska et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Cincinnati (Cincinnati, Ohio) |
| ASSIGNEE(S) | University of Cincinnati (Cincinnati, Ohio) |
| INVENTOR(S) | Maria Franciszka Czyzyk-Krzeska (Cincinnati, Ohio); Julio Alberto Landero Figueroa (Cincinnati, Ohio); Jarek Meller (Cincinnati, Ohio); David Plas (Cincinnati, Ohio); Shuchi Gulati (Cincinnati, Ohio); Bhargav Vemuri (Mason, Ohio); John Thomas Cunningham, IV (Maineville, Ohio) |
| ABSTRACT | A method of diagnosing the likelihood of recurrence of clear cell renal cell carcinoma is provided. The method involves a) detecting the gene expression signatures of mitochondrial electron transport chain subunits, mitochondrial ribosomal proteins, major histocompatibility complex class II (MHC-II) proteins or combinations thereof in a kidney tumor tissue sample; and b) determining that the subject has an elevated risk of recurrence of clear cell renal cell carcinoma if the gene expression signatures include certain sequences. In another embodiment, the method uses copper levels to diagnose the likelihood of recurrence of clear cell renal cell carcinoma. |
| FILED | Friday, May 21, 2021 |
| APPL NO | 17/327100 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57438 (20130101) G01N 2333/90216 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220135276 | Lee, SR. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James Edward Lee, SR. (St. Leonard, Maryland) |
| ABSTRACT | Embodiments of a reusable stackable shipping box are provided herein. The reusable stackable shipping box may be reused and cleaned without causing harm to the integrity of the box. In addition, the box is slightly tapered in shape such that the box may be stacked upon and within other boxes for ease in shipping and organization. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576703 |
| CURRENT CPC | Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 5/001 (20130101) Original (OR) Class B65D 5/10 (20130101) B65D 5/14 (20130101) B65D 5/0245 (20130101) B65D 5/0281 (20130101) B65D 5/4266 (20130101) B65D 5/4608 (20130101) B65D 5/48024 (20130101) Climate Change Mitigation Technologies Related to Wastewater Treatment or Waste Management Y02W 30/80 (20150501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220138891 | IRWIN |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald E. IRWIN (Fredericksburg, Virginia) |
| ABSTRACT | A system including a processor and a non-transitory computer-readable medium communicatively coupled to the processor and storing instructions executable by the processor is provided. When executed, the instructions cause the processor to receive, from a user, a rideshare request comprising an origination point and a destination location, determine that one or more parcels destined for delivery to the user are available for collection, identify, based on a collection location associated with each of the one or more parcels and at least one of the origination point and the destination location, a route that enables collection of at least one of the one or more parcels, and direct a rideshare operator to the collection location associated with at least one of the one or more parcels. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508240 |
| CURRENT CPC | Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/02 (20130101) G06Q 50/32 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Transportation (USDOT)
| US 20220139031 | Young et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | TRX Systems, Inc. (Greenbelt, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Travis Young (Rockville, Maryland); Daniel Hakim (Silver Spring, Maryland); Daniel Franchy (Catonsville, Maryland); Jared Napora (Severn, Maryland); John Karvounis (Bowie, Maryland); Jonathan Fetter Degges (Washington, District of Columbia); Tim Wang (Germantown, Maryland); Benjamin Funk (Hanover, Maryland); Carole Teolis (Glendale, Maryland); Carol Politi (Bethesda, Maryland); Stuart Woodbury (Ellicott City, Maryland) |
| ABSTRACT | Systems, methods and instructions for creating building models of physical structures is disclosed. The building model may be a collection of floors defined by outlines containing regions that may be offset relative to a main region, and a collection of connectors. Connectors may have connection points for tracking, routing and sizing. Connectors may indicate elevation changes through georeferenced structural features. Signal elements may also be features that provide corrections when tracking. Feature descriptors are data that describes the structural configuration and signal elements enabling them to be matched to previously collected data in a database. User interface elements assist a user of a tracking device in collecting floor information, structural features and signal features and validating certain collected information based on previously known information. The height of floors may also be inferred based on sensor data from the tracking device. |
| FILED | Wednesday, September 15, 2021 |
| APPL NO | 17/475935 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/13 (20200101) Image Data Processing or Generation, in General G06T 17/05 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220141557 | LEIGH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KEVIN B. LEIGH (Houston, Texas); LUCA RAMINI (Cernusco sul Naviglio(Milan), Italy); MIR ASHKAN SEYEDI (Milpitas, California); STEVEN DEAN (Chippenwa Falls, Wisconsin); MARCO FIORENTINO (Milpitas, California) |
| ABSTRACT | A photonic node includes a first circuit disposed on a first substrate and a second circuit disposed on a second substrate different from the first substrate. The first circuit is configured to route light signals originated from the photonic node to local nodes of a local group in which the photonic node is a member. The second circuit is configured to route light signals received from a node of an external group in which the photonic node is not a member, to one of the local nodes. |
| FILED | Friday, October 30, 2020 |
| APPL NO | 17/086044 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/43 (20130101) Selecting H04Q 11/0005 (20130101) Original (OR) Class H04Q 11/0066 (20130101) H04Q 2011/0052 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220135250 | Grizzle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James B. Grizzle (Oro Valley, Arizona); Tanner P. Reznicek (Aurora, Colorado); Cory M. Polivchak (Tucson, Arizona) |
| ABSTRACT | A universal payload manipulation tool employs a segmented ring captured in a telescoping cradle to perform the positioning functions of both a workstation and a loading adapter. The ring rotates over a range of 360 degrees to perform the position functions of the workstation. With the upper ring segment removed, the telescoping cradle rotates and the lower ring segment rotates and extends from the telescoping cradle over a combined range of rotation to position the payload at a specified angle for unloading to perform the position functions of a loading adapter. This configuration allows the universal tool to access confined spaces while supporting a range of rotation required in many applications for unloading the payload (loading the payload to another platform such as an aircraft). The manipulation tool may also be configured as only a loading adapter. |
| FILED | Wednesday, November 04, 2020 |
| APPL NO | 17/089475 |
| CURRENT CPC | Ground or Aircraft-carrier-deck Installations Specially Adapted for Use in Connection With Aircraft; Designing, Manufacturing, Assembling, Cleaning, Maintaining or Repairing Aircraft, Not Otherwise Provided For; Handling, Transporting, Testing or Inspecting Aircraft Components, Not Otherwise Provided for B64F 1/32 (20130101) Original (OR) Class Hoisting, Lifting, Hauling or Pushing, Not Otherwise Provided For, e.g Devices Which Apply a Lifting or Pushing Force Directly to the Surface of a Load B66F 9/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220137401 | Knotts et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Michael E. Knotts (Milford, New Hampshire); Adam J. Marcinuk (Lyndeborough, New Hampshire); Chris L. Willis (Hollis, New Hampshire) |
| ABSTRACT | A multi-axis rotary actuator includes a payload support configured to be rotatable about a first axis, a disk surrounding at least a portion of the payload support, and an elevation wheel rotatably coupled to the payload support. The disk is configured to be rotatable about the first axis. The elevation wheel is configured to be in contact with the disk and to be rotatable about a second axis perpendicular to the first axis. The actuator can include a mirror or other device coupled to the elevation wheel. The mirror or other device is configured to be rotatable about the first axis and the second axis as the payload support and the elevation wheel rotate about the first axis and the second axis, respectively. |
| FILED | Thursday, November 05, 2020 |
| APPL NO | 17/090317 |
| CURRENT CPC | Gearing F16H 48/16 (20130101) F16H 48/38 (20130101) Optical Elements, Systems, or Apparatus G02B 26/105 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220141237 | Ferguson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE Systems Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Richard J. Ferguson (Bealeton, Virginia); Michael Bear (Falls Church, Virginia); Sumit Ray (Broadlands, Virginia); Jeannine Robertazzi (Crozet, Virginia); Daniel L. Stanley (Warrenton, Virginia) |
| ABSTRACT | A method of detecting abnormal or malicious activity in a point-to-point or packet-switched data communication network includes tapping a link in the network to obtain a data stream transmitted from a node of the network in parallel with transmission of the data stream through the network. The tap is non-invasive because it does not interfere with the normal traversal of the data stream across the network. This is useful for certain applications, such as mission-critical systems, where it is desirable to monitor the network and inspect the data without adversely impacting or otherwise interfering with the normal operation of the system. The method further includes decoding a communication protocol encoded in the data stream to obtain payload data from the data stream, analyzing the payload data to detect abnormal or malicious activity, and notifying a host of the network of the detected abnormal or malicious activity in the payload data. |
| FILED | Thursday, November 05, 2020 |
| APPL NO | 17/090275 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 63/1416 (20130101) Original (OR) Class H04L 63/1425 (20130101) H04L 63/1441 (20130101) H04L 69/324 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, May 05, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20220505.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
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