FedInvent™ Patent Applications
Application Details for Thursday, May 19, 2022
This page was updated on Saturday, May 21, 2022 at 04:26 PM GMT
Department of Health and Human Services (HHS)
| US 20220151490 | Jia et al. |
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| FUNDED BY |
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| APPLICANT(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| ASSIGNEE(S) | OREGON HEALTH and SCIENCE UNIVERSITY (Portland, Oregon) |
| INVENTOR(S) | Yali Jia (Portland, Oregon); Yukun Guo (Portland, Oregon) |
| ABSTRACT | This disclosure describes systems, devices, and techniques for training neural networks to identify avascular and signal reduction areas of Optical Coherence Tomography Angiography (OCTA) images and for using trained neural networks. By identifying signal reduction areas in OCTA images, the avascular areas can be detected with high accuracy, even when the OCTA images include artifacts and other types of noise. Accordingly, various implementations described herein can accurately identify avascular areas from real-world clinical OCTA images. In various implementations, a method can include identifying images of retinas. The images may include thickness images, reflectance intensity maps, and OCTA images of the retinas. Avascular maps corresponding to the OCTA images can be identified. A neural network can be trained based on the images and the avascular maps. |
| FILED | Friday, April 24, 2020 |
| APPL NO | 17/606719 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/0058 (20130101) A61B 3/102 (20130101) A61B 3/1241 (20130101) Original (OR) Class A61B 5/7267 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10101 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30041 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/40 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151568 | Yao et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xincheng Yao (Chicago, Illinois); Minhaj Alam (Chicago, Illinois); Tae Yun Son (Chicago, Illinois) |
| ABSTRACT | An artificial intelligence (AI) system is disclosed that uses machine learning to classify retinal features contained in OCTA data acquired by a data acquisition system and to predict one or more retinopathies based on the classification of retinal features. The AI system comprise a processor configured to run a classifier model comprising a machine learning algorithm and a memory device that stores the classifier model, OCTA training data and acquired OCT A data. The machine learning algorithm performs a process that trains the classifier model to classify retinal features contained in OCT A training data. The trained machine learning algorithm uses the classifier model to process acquired OCT A data to classify retinal features contained in the acquired OCTA data and to predict, based on the classified retinal features, whether the acquired OCTA data is indicative of at least one of a plurality of retinopathies |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/438700 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/102 (20130101) A61B 3/1241 (20130101) A61B 5/02007 (20130101) A61B 5/7267 (20130101) A61B 5/7275 (20130101) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 30/40 (20180101) G16H 50/20 (20180101) G16H 50/70 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151658 | McDonnall et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ripple, LLC (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Allen McDonnall (Salt Lake City, Utah); Nathaniel Anthony Srok (Salt Lake City, Utah); Christopher Farand Smith (North Salt Lake, Utah) |
| ABSTRACT | Disclosed herein are systems and methods for insertion tools for implanting electrode leads. In one embodiment, an insertion tool comprises a shaft having an outer cannula and an inner cannula. An actuator may be configured to transition the insertion tool between at least three configurations. In a first configuration, the inner cannula and the outer cannula are configured to receive the lead in the shaft. In a second configuration, the inner cannula and the outer cannula are configured to secure the lead in the shaft. In a third configuration, the inner cannula and the outer cannula are configured to cause the lead to separate from the insertion tool and implant in adjacent tissue. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/591843 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3421 (20130101) A61B 17/3468 (20130101) Original (OR) Class A61B 2017/00438 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/05 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151676 | Rollins et al. |
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| FUNDED BY |
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| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew M. Rollins (Cleveland Heights, Ohio); Christine P. Fleming (Bronx, New York) |
| ABSTRACT | Systems, methods, and other embodiments associated with characterizing Radio Frequency Ablation (RFA) lesions using Optica Coherence Tomography (OCT) are described. One example method includes acquiring an OCT signal from a Region Of Interest (ROI) in an ablated material. The example method may also include determining whether a lesion was formed by the ablation by analyzing optical properties of the ROI as recorded in the OCT signal. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589222 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0066 (20130101) A61B 5/6852 (20130101) A61B 18/12 (20130101) Original (OR) Class A61B 18/1492 (20130101) A61B 2017/00243 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151770 | DUAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Xiangfeng DUAN (Los Angeles, California); Yu HUANG (Los Angeles, California); Chao MA (Los Angeles, California) |
| ABSTRACT | In some embodiments, a suction-based tool for positioning an intraocular implant includes a tool body defining an internal channel; a suction extension extending through the internal channel; and a suction attachment connected to an end of the suction extension. In additional embodiments, a suction-based tool for positioning an intraocular implant includes: a tool body including a tool tip; a joint at an end of the tool tip; and a suction attachment connected to the tool tip via the joint. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/528080 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/30 (20130101) A61B 2017/306 (20130101) Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/1664 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151924 | Brinker et al. |
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| FUNDED BY |
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| APPLICANT(S) | C. Jeffrey Brinker (Albuquerque, New Mexico); Jimin Guo (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | C. Jeffrey Brinker (Albuquerque, New Mexico); Jimin Guo (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico) |
| ABSTRACT | A method to prepare a population of metal-organic polyhedra (MOP) supported micelle nanoparticles (NPs), and a composition comprising MOP supported micelle NPs, are provided. |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 17/434363 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Original (OR) Class A61K 31/704 (20130101) A61K 33/242 (20190101) A61K 47/10 (20130101) A61K 47/24 (20130101) A61K 47/6849 (20170801) A61K 47/6907 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151928 | Henrich et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Stephen E. Henrich (Chicago, Illinois); C. Shad Thaxton (Chicago, Illinois); Sonbinh T. Nguyen (Evanston, Illinois); Bong Jin Hong (Evanston, Illinois) |
| ABSTRACT | Disclosed herein are spherical high-density lipoprotein-like nanoparticles (HDL-NP) having a soft material core (e.g., a lipid-conjugated inorganic core). Also disclosed herein are methods for synthesizing the spherical HDL-NPs. Also disclosed herein are methods for treating disorders such as cardiovascular disease, cancer, inflammatory disorders or reducing NF-kB activity with the spherical HDL-NPs. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/425401 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1275 (20130101) Original (OR) Class A61K 31/713 (20130101) A61K 47/54 (20170801) A61K 47/544 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151948 | Zhang et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liangfang Zhang (San Diego, California); Che-Ming Jack Hu (Novato, California); Ronnie H. Fang (San Diego, California); Brian T. Luk (San Diego, California); Kuei-Chun Wang (San Diego, California); Shu Chien (La Jolla, California) |
| ABSTRACT | The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590684 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) A61K 9/5169 (20130101) A61K 9/5176 (20130101) Original (OR) Class A61K 31/337 (20130101) A61K 47/6901 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) A61P 9/00 (20180101) A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151964 | Chandraratna et al. |
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| FUNDED BY |
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| APPLICANT(S) | Io Therapeutics, Inc. (Spring, Texas); Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Roshantha A. Chandraratna (San Juan Capistrano, California); Ethan Dmitrovsky (Hanover, New Hampshire); Elizabeth Nowak (West Lebanon, New Hampshire); Randolph Noelle (Plainfield, New Hampshire) |
| ABSTRACT | The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/586657 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0073 (20130101) A61K 31/47 (20130101) A61K 31/192 (20130101) Original (OR) Class A61K 31/201 (20130101) A61K 31/216 (20130101) A61K 31/343 (20130101) A61K 31/353 (20130101) A61K 31/4704 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152003 | Abergel et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca J. Abergel (Kensington, California); Taylor A. Choi (South San Francisco, California); Kenneth N. Raymond (Berkeley, California); David K. Shuh (Oakland, California) |
| ABSTRACT | Provided herein are pharmaceutical formulations comprising a 1,2-HOPO chelating agent and/or a 3,2-HOPO chelating agent. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/665135 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0056 (20130101) A61K 9/0095 (20130101) A61K 9/1611 (20130101) A61K 9/1623 (20130101) A61K 9/1652 (20130101) A61K 9/2009 (20130101) A61K 9/2018 (20130101) A61K 9/2054 (20130101) A61K 31/444 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152005 | COOP et al. |
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| FUNDED BY |
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| APPLICANT(S) | Andrew COOP (Columbia, Maryland); Chad R. Johnson (Baltimore, Maryland); Jack BERGMAN (Cambridge, Massachusetts); Brian D. KANGAS (Boston, Massachusetts); James H. WOODS (San Antonio, Texas); Emily M. JUKIEWICZ (Dexter, Michigan); Gail WINGER (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew COOP (Columbia, Maryland); Chad R. Johnson (Baltimore, Maryland); Jack BERGMAN (Cambridge, Massachusetts); Brian D. KANGAS (Boston, Massachusetts); James H. WOODS (San Antonio, Texas); Emily M. JUKIEWICZ (Dexter, Michigan); Gail WINGER (Ann Arbor, Michigan) |
| ABSTRACT | Muscarinic antagonist are provided that are used in the treatment of depression in a subject, such as humans. The muscarinic antagonist of the invention can relieve depression without effecting cognitive functions in the treated subject. |
| FILED | Monday, April 06, 2020 |
| APPL NO | 17/600347 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/439 (20130101) A61K 31/4406 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/24 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152035 | Ruggero et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Davide Ruggero (Emerald Hill, California); Hao Nguyen (San Francisco, California); Peter Carroll (San Francisco, California); Crystal Conn (Oakland, California) |
| ABSTRACT | In cancers such as prostate cancer, the combination of PTEN loss and activation of Myc activates an adaptive stress response that enables tumor cells to escape the stress of massively upregulated protein synthesis. This pro-survival response is mediated by the PERK-phosphorylated eIF2α axis of the UPR adaptive response. Agents that disrupt PERK-eIF2α pathways disrupt the adaptive response and lead to cancer cell death from uncontrolled growth. For example, ISRIB and derivatives may be employed as therapeutic agents to disrupt PERK-mediated adaptive mechanisms. Additionally PTEN loss and activation of Myc provides a diagnostic marker that enables better prognosis and the selection of amenable treatments. |
| FILED | Friday, January 14, 2022 |
| APPL NO | 17/576623 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/519 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/02 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/57434 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152041 | ZON et al. |
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| FUNDED BY |
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| APPLICANT(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Leonard I. ZON (Wellesley, Massachusetts); Alison M. TAYLOR (Cambridge, Massachusetts) |
| ABSTRACT | The present invention relates generally to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathy, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to methods for the use of calmodulin inhibitors and calcium channel blockers for treatment of ribosomal disorders and ribosomopathy, e.g. Diamond Blackfan anemia (DBA). |
| FILED | Monday, June 21, 2021 |
| APPL NO | 17/353717 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/54 (20130101) A61K 31/145 (20130101) A61K 31/495 (20130101) A61K 31/553 (20130101) Original (OR) Class A61K 31/4184 (20130101) A61K 31/4375 (20130101) A61K 31/4418 (20130101) A61K 31/4965 (20130101) A61K 31/5415 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152071 | Awah et al. |
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| FUNDED BY |
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| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chidiebere U. Awah (Chicago, Illinois); Li Chen (Evanston, Illinois); Mukesh Bansal (Paramus, New Jersey); Adam M. Sonabend (Chicago, Illinois) |
| ABSTRACT | Disclosed are methods, components, and systems for diagnosing, prognosing, and treating a cell proliferative disease or disorder such as cancer. The methods, components, and systems relate to identifying markers that may be utilized to diagnose and/or prognose a subject and optionally treat the diagnosed and/or prognosed subject by administering a topoisomerase poison to the subject based on the marker having been identified. Markers identified in the methods may include ribosomal subunit proteins and genes encoding ribosomal subunit proteins. Based on the marker being identified in the subject, the subject may be identified as having responsiveness to a topoisomerase poison, such as etoposide and/or doxombicin. As such, the subject may be treated by administering the topoisomerase poison to treat the cell proliferative disease or disorder after the marker has been identified. |
| FILED | Wednesday, April 01, 2020 |
| APPL NO | 17/594119 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/635 (20130101) A61K 31/704 (20130101) A61K 31/7048 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) G01N 33/57449 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152083 | Jones et al. |
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| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | University of Massachusetts (Boston, Massachusetts) |
| INVENTOR(S) | Peter L. Jones (Carson City, Nevada); Michael R. Green (Boylston, Massachusetts) |
| ABSTRACT | The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy). |
| FILED | Thursday, September 30, 2021 |
| APPL NO | 17/489983 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/713 (20130101) A61K 31/7105 (20130101) Original (OR) Class A61K 45/06 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/90 (20130101) C12N 15/113 (20130101) C12N 2310/11 (20130101) C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2740/16043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152085 | DONG et al. |
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| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yizhou DONG (Dublin, Ohio); Wenqing LI (Columbus, Ohio); Chengxiang ZHANG (Columbus, Ohio) |
| ABSTRACT | The present disclosure relates to compositions and methods for regulating the immune system and for treating cancers and other immune disorders. |
| FILED | Wednesday, March 25, 2020 |
| APPL NO | 17/442495 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) A61K 31/7115 (20130101) Original (OR) Class A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152102 | Liu |
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| FUNDED BY |
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| APPLICANT(S) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Dongfang Liu (Millburn, New Jersey) |
| ABSTRACT | Disclosed herein are methods and compositions for generating immunotherapeutic cells (e.g., NK and T cells) with enhanced cytotoxicity and capacity for expansion thereof. The methods and compositions disclosed herein can further be used for enhanced expansion of CAR-modified NK and T cells with increased cytotoxicity. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 17/432380 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 38/20 (20130101) A61K 38/1774 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0635 (20130101) C12N 5/0636 (20130101) C12N 5/0646 (20130101) C12N 15/86 (20130101) C12N 2501/2302 (20130101) C12N 2501/2315 (20130101) C12N 2501/2321 (20130101) C12N 2502/1107 (20130101) C12N 2740/10043 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152106 | Liu |
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| FUNDED BY |
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| APPLICANT(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| ASSIGNEE(S) | Rutgers, The State University of New Jersey (New Brunswick, New Jersey) |
| INVENTOR(S) | Dongfang Liu (Millburn, New Jersey) |
| ABSTRACT | Modified single chain variable fragments (scFv) that specifically bind CD147 are provided. Also provided are chimeric antigen receptors (CARs) including the modified CD147 scFv, nucleic acids encoding the CARs, vectors including the nucleic acids encoding the CARs, and immune cells expressing the CARs. Methods of treating a subject with cancer including administering to the subject an immune cell expressing a disclosed CD147-CAR are also provided. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 17/438741 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/7051 (20130101) C07K 16/2803 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152115 | Zhang |
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| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts) |
| ABSTRACT | Embodiments of the disclosure include compositions and methods for treating diseases (e.g., brain diseases) using genetic engineered cells. In some cases, the cells are engineered hematopoietic stem cells (HSCs), which are capable of engrafting to a central nervous system and differentiating to progeny cells (e.g., microglial cells). |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/437485 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) C12N 5/0647 (20130101) C12N 9/22 (20130101) C12N 15/111 (20130101) C12N 2310/20 (20170501) C12N 2320/32 (20130101) C12N 2506/11 (20130101) C12N 2506/45 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152117 | MURRY et al. |
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| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| INVENTOR(S) | Charles E. MURRY (SEATTLE, Washington); Xiulan YANG (SEATTLE, Washington) |
| ABSTRACT | Described herein are methods and compositions related to promoting maturation of in vitro-differentiated cardiomyocytes and in vitro-differentiated neurons, and methods and compositions using the resulting cardiomyocytes and neurons. |
| FILED | Tuesday, March 17, 2020 |
| APPL NO | 17/440266 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/34 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0619 (20130101) C12N 5/0657 (20130101) C12N 9/12 (20130101) C12N 2501/727 (20130101) C12N 2506/45 (20130101) Enzymes C12Y 207/11031 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152128 | Moran et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nancy A. Moran (Austin, Texas); Sean Leonard (Austin, Texas); Waldan Kwong (Vancouver, Canada); Jenkyn Elijah Powell (Austin, Texas) |
| ABSTRACT | Provided herein are defined bacterial co-cultures, and methods of generating the same. Further provided are methods of using the defined bacterial co-cultures as probiotics to prevent diseases or disorders in bees and bee colonies. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 17/431813 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/741 (20130101) A61K 35/745 (20130101) A61K 35/747 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152146 | Watnick |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| ASSIGNEE(S) | CHILDREN'S MEDICAL CENTER CORPORATION (Boston, Massachusetts) |
| INVENTOR(S) | Randolph S. Watnick (Newton, Massachusetts) |
| ABSTRACT | Provided herein are cyclic prosaposin peptides and compositions and uses thereof. Exemplary uses include use in the treatment of cancer or in the treatment of inflammatory diseases or disorders. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518074 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/08 (20130101) A61K 38/12 (20130101) Original (OR) Class Peptides C07K 7/64 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152148 | Burkett et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts); The Brigham and Women's Hospital, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Patrick R. Burkett (Boston, Massachusetts); Se-Jin Kim (Boston, Massachusetts); Samantha J. Riesenfeld (Cambridge, Massachusetts); Antonia Wallrapp (Boston, Massachusetts); Vijay K. Kuchroo (Boston, Massachusetts); Aviv Regev (Cambridge, Massachusetts) |
| ABSTRACT | Interleukin (IL)-33 is a critical regulator of allergic airway inflammation in the lung and is released by stressed or damaged epithelial cells. Here, Applicants show that alveolar macrophages regulate epithelial alarmin expression via CLEC-2 (C-type Lectin-like Receptor-2), which binds to PDPN (podoplanin). Therefore, CLEC-2/PDPN interactions are critical for regulating type 2 immunity in the lung and modulating expression of the epithelial alarmin IL-33. Methods are disclosed for therapeutic and screening applications. Novel therapeutic targets in alveolar macrophages and epithelial cells are disclosed. |
| FILED | Wednesday, March 18, 2020 |
| APPL NO | 17/440226 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/177 (20130101) Original (OR) Class A61K 38/1735 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5055 (20130101) G01N 33/56972 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152170 | Seder et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Robert Seder (Chevy Chase, Maryland); Geoffrey Lynn (Bethesda, Maryland) |
| ABSTRACT | Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example, nanoparticle polyplexes are provided that comprise a polymer linked to a peptide conjugate by an electrostatic interaction. The conjugate comprises a peptide antigen linked to a peptide tag through an optional linker. An adjuvant may be included in the nanoparticle polyplex, linked to either the polymer or the conjugate, or admixed with the nanoparticles. The nanoparticle polyplex can be administered to a subject to induce an immune response to the peptide antigen. |
| FILED | Tuesday, November 02, 2021 |
| APPL NO | 17/517597 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 39/0011 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 39/001102 (20180801) A61K 2039/60 (20130101) A61K 2039/555 (20130101) A61K 2039/6093 (20130101) A61K 2039/55555 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152188 | Carson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dennis A. Carson (La Jolla, California); Howard B. Cottam (La Jolla, California); Tomoko Hayashi (San Diego, California); Mary Patricia Corr (San Diego, California) |
| ABSTRACT | A method to enhance an immune response in a mammal, and a composition comprising liposomes, a TLR4 agonist and a TLR7 agonist, are provided. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/438934 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/12 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/5252 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152192 | OH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| ASSIGNEE(S) | BAYLOR RESEARCH INSTITUTE (Dallas, Texas) |
| INVENTOR(S) | SangKon OH (Baltimore, Maryland); Dapeng LI (Davis, California) |
| ABSTRACT | The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/454108 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/145 (20130101) Original (OR) Class A61K 47/6849 (20170801) A61K 51/1027 (20130101) A61K 2039/5154 (20130101) Peptides C07K 14/005 (20130101) C07K 14/37 (20130101) C07K 14/195 (20130101) C07K 14/405 (20130101) C07K 14/435 (20130101) C07K 16/28 (20130101) C07K 2317/56 (20130101) C07K 2317/74 (20130101) C07K 2317/75 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0639 (20130101) C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152194 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America, as represented by the Secretary, Department of Health and Human Servic (Bethesda, Maryland) |
| INVENTOR(S) | Xuejun Chen (Clarksburg, Maryland); Jeffrey Boyington (Clarksburg, Maryland); Hongying Duan Holdsworth (McLean, Virginia); Cheng Cheng (Bethesda, Maryland); John R. Mascola (Rockville, Maryland) |
| ABSTRACT | Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587817 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/21 (20130101) Original (OR) Class A61K 2039/5258 (20130101) Peptides C07K 14/005 (20130101) C07K 14/162 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Enzymes C12Y 205/01078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152196 | WANG |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE UAB RESEARCH FOUNDATION (Birmingham, Alabama) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pengfei WANG (Hoover, Alabama) |
| ABSTRACT | A number of MS- and natural-saponin-based vaccine adjuvant candidates have been prepared. The MS derivatives were prepared by incorporating a terminal-functionalized side chain into the C3 glucuronic acid unit of the natural saponins MS I and II through amide formation reaction; and the QS analogs were prepared via multi-step organic synthesis. These unnatural saponins showed significantly different immunostimulant activity profiles, suggesting that the structure of side chain, triterpenoid core, and oligosaccharide domain together orchestrate each saponin's characteristic potentiation of immune responses. |
| FILED | Tuesday, March 17, 2020 |
| APPL NO | 17/440009 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) Original (OR) Class A61K 45/06 (20130101) A61K 47/26 (20130101) A61K 2039/55577 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152217 | de los Pinos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Aura Biosciences, Inc. (Cambridge, Massachusetts); The USA, as Represented by the Secretary, Department of Health and Human Service (Bethesda, Maryland) |
| ASSIGNEE(S) | Aura Biosciences, Inc. (Cambridge, Massachusetts); The USA, as Represented by the Secretary, Department of Health and Human Service (Bethesda, Maryland) |
| INVENTOR(S) | Elisabet de los Pinos (Brookline, Massachusetts); John Todd Schiller (Kensington, Maryland); Rhonda C. Kines (Washington, District of Columbia) |
| ABSTRACT | Some embodiments of the present disclosure are directed to methods and compositions for the treatment of tumors, using a combination of immunotherapeutic agents and tumor-targeting viral capsid protein assemblages comprising anti-cancer molecules conjugated to viral capsid proteins. |
| FILED | Wednesday, April 11, 2018 |
| APPL NO | 16/604790 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 41/0061 (20130101) A61K 41/0071 (20130101) A61K 41/0076 (20130101) A61K 47/6901 (20170801) Original (OR) Class A61K 2039/545 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152219 | Schoenfisch et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark H. Schoenfisch (Chapel Hill, North Carolina); Maggie Malone-Povolny (Carrboro, North Carolina) |
| ABSTRACT | The subject matter disclosed herein is directed to nitric oxide releasing particles comprising a mesoporous silica network. Also disclosed are compositions comprising one or more nitric-oxide releasing particles and a polymer. In one aspect, the particles are admixed with the polymer. The compositions exhibit high payloads of nitric oxide release without particle leaching or the need for extremely cold storage conditions. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 17/435313 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/146 (20130101) A61K 33/00 (20130101) A61K 47/6923 (20170801) Original (OR) Class A61K 47/6929 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152227 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Guanshu Liu (Nottingham, Maryland); Zheng Han (Greenbelt, Maryland) |
| ABSTRACT | Described are compositions and methods of manufacturing extracellular vesicles comprising sticky imaging particles. In one aspect, methods include associating a sticky element to imaging particles forming sticky imaging particles. The sticky imaging particles are associated with extracellular vesicles (EV) to form a mixture comprising extracellular vesicles (EV) that comprise sticky imaging particles. The method also include separating the sticky imaging particles associated with EVs from sticky imaging particle that are not associated with EVs. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/438874 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/085 (20130101) A61K 49/1812 (20130101) A61K 49/1872 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152228 | THOREK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri); Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri); Cornell University (Ithaca, New York) |
| INVENTOR(S) | Daniel THOREK (St. Louis, Missouri); Diane ABOU (St. Louis, Missouri); Justin WILSON (Ithaca, New York); Nikki THIELE (Ithaca, New York) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of compositions of isotope-ligand complexes, methods of use thereof, and methods of chelating isotopes. The present disclosure also provides for methods for modulating ion channel transportation of radiopharmaceuticals. For example, the inhibition of radiopharmaceutical transport comprises administering an ion channel transport modulating or inhibiting agent (e.g., a calcium channel inhibitor) in an amount effective to inhibit gastrointestinal uptake. |
| FILED | Sunday, March 01, 2020 |
| APPL NO | 17/432733 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/18 (20130101) A61K 31/196 (20130101) A61K 31/235 (20130101) A61K 31/365 (20130101) A61K 31/415 (20130101) A61K 31/496 (20130101) A61K 31/4166 (20130101) A61K 31/4422 (20130101) A61K 31/4725 (20130101) A61K 31/4965 (20130101) A61K 51/088 (20130101) A61K 51/0482 (20130101) Original (OR) Class A61K 51/1096 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 39/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152273 | KYRIAKIDES et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Themis KYRIAKIDES (Branford, Connecticut); Nina KRISTOFIK (Wallingford, Connecticut) |
| ABSTRACT | The present invention relates to novel compositions and methods for reducing or eliminating the thrombogenicity of a graft by modifying the graft with a cell-derived extracellular matrix lacking thrombospondin-2 (TSP2-null ECM) to render it non-thrombogenic when transplanted to a subject in need thereof. The invention also provides a method for improving the biocompatibility of a medical device or an implant by modifying the medical device or implant with a cell-derived TSP2-null ECM, whereby the medical device or implant is rendered non-thrombogenic and pro-migratory. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/524038 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/28 (20130101) Original (OR) Class A61L 27/34 (20130101) A61L 27/54 (20130101) A61L 27/3633 (20130101) A61L 29/085 (20130101) A61L 31/10 (20130101) A61L 33/18 (20130101) A61L 33/128 (20130101) A61L 2300/42 (20130101) A61L 2300/606 (20130101) A61L 2430/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152274 | Lee et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jungwoo Lee (Boston, Massachusetts); Jaehyuck Shim (Boston, Massachusetts); Ryan Carpenter (Boston, Massachusetts); Yongkuk Park (Boston, Massachusetts); Jun-Goo Kwak (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein are three-dimensional bone tissue grafts produced from stacked demineralized bone paper. Also disclosed are methods for treating a subject using tissue grafts produced from the disclosed demineralized bone paper. Also disclosed are assay systems that involves culturing bone-promoting cells on the disclosed demineralized bone paper. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531328 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3608 (20130101) Original (OR) Class A61L 27/3683 (20130101) A61L 2300/414 (20130101) A61L 2430/02 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 23/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0669 (20130101) C12N 2527/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2813 (20130101) G01N 33/4833 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152385 | Tai |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburgh - Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Changfeng Tai (Wexford, Pennsylvania) |
| ABSTRACT | Provided herein are methods for treating underactive bladder, urinary retention, detrusor-sphincter dyssynergia after spinal cord injury, constipation, and/or infrequent bowel movements including the step of applying electrical stimulation to one or more peripheral nerves. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587593 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36007 (20130101) Original (OR) Class A61N 1/36034 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152399 | Han et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Connecticut (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Martin Han (Mansfield, Connecticut); Sabato Santaniello (Vernon, Connecticut) |
| ABSTRACT | A deep brain stimulation (DBS) system provides for treating a human brain exhibiting a pathological condition. A controller generates a signal waveform defining a series of DBS pulses within an amplitude modulation envelope. The frequency of the amplitude modulation envelope may be less than or equal to half of a frequency of the DBS pulses. A driver circuit generates an amplified, amplitude-modulated electrical waveform corresponding to the signal waveform. A DBS electrode electrically coupled to the driver circuit converts the electrical waveform to a stimulation waveform to entrain neurons of the deep brain tissue in a normal oscillation pattern, thereby suppressing the pathological oscillation pattern to treat the pathological condition. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/438856 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0534 (20130101) A61N 1/36064 (20130101) A61N 1/36067 (20130101) A61N 1/36096 (20130101) A61N 1/36132 (20130101) A61N 1/36139 (20130101) A61N 1/36171 (20130101) Original (OR) Class A61N 1/36192 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152651 | Ma et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bo Ma (Palo Alto, California); Kamyar Firouzi (Palo Alto, California); Butrus T. Khuri-Yakub (Palo Alto, California); Jose Joseph (Stanford, California) |
| ABSTRACT | Aspects of this disclosure relate to driving a capacitive micromachined ultrasonic transducer (CMUT) with a pulse train of unipolar pulses. The CMUT may be electrically excited with a pulse train of unipolar pulses such that the CMUT operates in a continuous wave mode. In some embodiments, the CMUT may have a contoured electrode. |
| FILED | Tuesday, September 28, 2021 |
| APPL NO | 17/449235 |
| CURRENT CPC | Methods or Apparatus for Generating or Transmitting Mechanical Vibrations of Infrasonic, Sonic, or Ultrasonic Frequency, for Performing Mechanical Work in General B06B 1/0215 (20130101) Original (OR) Class B06B 1/0292 (20130101) B06B 1/0651 (20130101) B06B 1/0662 (20130101) B06B 2201/55 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0021 (20130101) B81B 2201/0271 (20130101) B81B 2203/04 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00166 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 29/22 (20130101) G01N 29/0654 (20130101) G01N 29/2406 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152665 | ATHEY |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | En Solución, Inc. (Austin, Texas) |
| ASSIGNEE(S) | En Solución, Inc. (Austin, Texas) |
| INVENTOR(S) | ALEX EDWARD ATHEY (Austin, Texas) |
| ABSTRACT | A system may include a circulation subsystem and a circuit coupled to the circulation subsystem. The circuit may provide one or more signals to control the circulation subsystem to circulate a treatment solution including one or more of microbubbles or nanobubbles in a selected ratio. In one aspect, the nanobubbles may include a first gas, and the microbubbles may include a second gas. In another aspect, the treatment solution may include a first percentage of nanobubbles and a second percentage of microbubbles. In another aspect, mechanical agitation can be applied to the solution on an object to assist in cleaning. |
| FILED | Monday, March 09, 2020 |
| APPL NO | 17/437822 |
| CURRENT CPC | Cleaning in General; Prevention of Fouling in General B08B 1/002 (20130101) B08B 3/08 (20130101) B08B 3/022 (20130101) B08B 3/041 (20130101) B08B 3/102 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153589 | Nel et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Andre E. Nel (Sherman Oaks, California); Tian Xia (Los Angeles, California); Ruibin Li (Los Angeles, California); Mark C. Hersam (Wilmette, Illinois); Nikhita D. Mansukhani (Allston, Massachusetts); Linda Guiney (Chicago, Illinois) |
| ABSTRACT | In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (.C) density. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531651 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/90 (20130101) A01N 59/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/08 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/198 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153596 | Turker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melik Z. Turker (Princeton, New Jersey); Thomas C. Gardinier (Raritan, New Jersey); Ulrich B. Wiesner (Ithaca, New York); Kai Ma (Belle Mead, New Jersey) |
| ABSTRACT | Silica nanorings, methods of making silica nanorings, and uses of silica nanorings. The silica nanorings may be PEGylated. The silica nanorings may be surface functionalized, which may be surface selective functionalization, with one or more polyethylene glycol (PEG) group(s), one or more display group(s), one or more functional group(s), or a combination thereof. The silica nanorings may have a size of 5 to 20 nm. The silica nanorings may be made using micelles. The absence or presence of the micelles during PEGylation and/or functionalization allows for surface selective functionalization. The silica nanorings may be used in various diagnostic and/or treatment methods. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/459562 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 33/00 (20130101) A61K 49/005 (20130101) A61K 51/1244 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/124 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153685 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburg-Of the Commonealth System of Higher Education (Pittsburgh, Pennsylvania); The United States as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beibei Chen (Pittsburgh, Pennsylvania); Rama K. Mallampalli (Solon, Iowa); Yuan Liu (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described herein are compounds that disrupt the interaction between Fbxo48 and phosphorylated-AMPK. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313577 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Acyclic or Carbocyclic Compounds C07C 215/08 (20130101) C07C 215/18 (20130101) C07C 217/34 (20130101) Original (OR) Class Heterocyclic Compounds C07D 205/04 (20130101) C07D 217/04 (20130101) C07D 311/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153709 | VILLAGRA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The George Washington University, A Congressionally Chartered Not-for-Profit Corporation (Washington, District of Columbia); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The George Washington University, A Congressionally Chartered Not-for-Profit Corporation (Washington, District of Columbia); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Alejandro VILLAGRA (Falls Church, Virginia); Alan P. KOZIKOWSKI (Chicago, Illinois); Sida SHEN (Chicago, Illinois) |
| ABSTRACT | The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590503 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 261/18 (20130101) Original (OR) Class C07D 413/06 (20130101) C07D 417/06 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153711 | Glenn et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey S. Glenn (Palo Alto, California); Mark Smith (San Francisco, California); Edward A. PHAM (Palo Alto, California); Kaustabh BASU (Redwood City, California); Stephen STABLER (Redwood City, California) |
| ABSTRACT | Compounds and methods are provided for inhibiting a PI4-kinase Methods of treating a pathogen infection and methods of treating cancer are also provided. The PI4-kinase inhibitor can be a compound that is a 5-aryl or heteroaryl-thiazole, e.g., as described herein. In certain embodiments, the PI4-kinase inhibitor is a substituted 2-amino-5-phenylthiazole or substituted 2-amino-5-pyridylthiazole compound. In some embodiments, the compounds have broad spectrum anti-infective activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of treating a subject for cancer using a PI4-kinase inhibitor. Aspects of the methods include inhibiting PI4-kinase in a cancer cell to reduce cellular proliferation. |
| FILED | Thursday, March 19, 2020 |
| APPL NO | 17/439085 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/12 (20180101) A61P 35/00 (20180101) Heterocyclic Compounds C07D 233/88 (20130101) C07D 263/48 (20130101) Original (OR) Class C07D 277/42 (20130101) C07D 401/12 (20130101) C07D 401/14 (20130101) C07D 405/12 (20130101) C07D 413/12 (20130101) C07D 417/12 (20130101) C07D 417/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153720 | Papa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feroz R. Papa (San Francisco, California); Bradley J. Backes (San Francisco, California); Dustin J. Maly (Seattle, Washington) |
| ABSTRACT | Disclosed herein, inter alia, are compounds for inhibiting IRE1α and uses thereof. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/525764 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/10 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153722 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | DANA-FARBER CANCER INSTITUTE, INC. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael Gray (Stanford, California); Nicholas Kwiatkowski (Brookline, Massachusetts); Eric Fischer (Chestnut Hill, Massachusetts); Katherine Donovan (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts); Mingxing Teng (Boston, Massachusetts); Jie Jiang (Brookline, Massachusetts) |
| ABSTRACT | The present invention relates to bifunctional compounds, compositions, and methods for treating diseases or conditions mediated by dysfunctional cyclin-dependent kinase 2 (CDK2) and CDK5 activity. |
| FILED | Thursday, April 02, 2020 |
| APPL NO | 17/442923 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 417/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153723 | Papa et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Feroz R. Papa (San Francisco, California); Bradley J. Backes (San Francisco, California); Dustin J. Maly (Seattle, Washington) |
| ABSTRACT | Disclosed herein, inter alia, are compounds for inhibiting IRE1α and uses thereof. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/525778 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/04 (20130101) C07D 401/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153730 | Gray et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Nathanael S. Gray (Boston, Massachusetts); Tinghu Zhang (Brookline, Massachusetts) |
| ABSTRACT | The present invention provides novel compounds according to Formula (I): where Ring A, Ring B, X, L1, L2, RA, RC, RD, RE, m, n, and p are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of human diseases associated with kinase activity, for example, proliferative diseases, neurodegenerative diseases, metabolic disorders, inflammatory diseases, and cardiovascular diseases. |
| FILED | Friday, February 26, 2021 |
| APPL NO | 17/186651 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/437 (20130101) A61K 31/444 (20130101) Heterocyclic Compounds C07D 401/04 (20130101) C07D 403/04 (20130101) C07D 403/06 (20130101) C07D 417/04 (20130101) C07D 417/06 (20130101) Original (OR) Class C07D 471/04 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153803 | Topp et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); Monon Bioventures, LLC (Fishers, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth M. Topp (Dublin, Ireland); Mark L. Heiman (Indianapolis, Indiana) |
| ABSTRACT | Modified glucagon molecules and buffer and/or excipient solutions are provided that result in the glucagon molecules being resistant to oxidation when stored at a substantially neutral pH. Such a modified glucagon molecule includes a substitution at position 27, with the native methionine being replaced with a methionine memetic analog, a norleucine, or an isomer of either of the foregoing. Optionally, the modified glucagon molecules may be further phosphorylated to result in enhanced solubility at a substantially neutral pH and resistance to fibrillation. Methods of using such molecules in pharmaceutical compositions and therapeutic kits are also provided. |
| FILED | Monday, March 16, 2020 |
| APPL NO | 17/439732 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Peptides C07K 14/605 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153812 | Arnaout |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE GENERAL HOSPITAL CORPORATION (BOSTON, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | M. Amin Arnaout (Chestnut Hill, Massachusetts) |
| ABSTRACT | Provided herein are integrin antagonists and methods of using the same. For example, one or more of the compounds or polypeptides provided herein can be used in the treatment of disorders such as heart attacks, stroke, and cancer metastasis. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390653 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 7/64 (20130101) C07K 14/47 (20130101) C07K 14/78 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153824 | Song et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Wenchao Song (Bryn Mawr, Pennsylvania); Sayaka Sato (Philadelphia, Pennsylvania); Takashi Miwa (Bala Cynwyd, Pennsylvania); Damodar Gullipalli (Philadelphia, Pennsylvania) |
| ABSTRACT | This invention relates to inhibition of the complement signaling using an anti-C5a antibody. Specifically, the invention relates to methods of treating a complement-mediated disease or complement-mediated disorder in an individual by contacting the individual with an anti-C5a antibody. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/591109 |
| CURRENT CPC | Peptides C07K 16/18 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/54 (20130101) C07K 2317/76 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 2015/8518 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153826 | KEANE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Miami (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert W. KEANE (Miami, Florida); W. Dalton DIETRICH (Miami, Florida); Juan Pablo De Rivero VACCARI (Miami, Florida); Helen M. BRAMLETT (Miami, Florida) |
| ABSTRACT | The compositions and methods described herein include methods and agents that inhibit inflammasome signaling in a mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s) or other agents. Also described herein are compositions and methods of use thereof for treating viral-associated lung inflammation, for example lung inflammation associated with viral infections such as SARS-CoV-2. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/525338 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/727 (20130101) A61K 39/3955 (20130101) A61K 39/39541 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 11/00 (20180101) A61P 25/00 (20180101) A61P 25/14 (20180101) A61P 25/28 (20180101) A61P 29/00 (20180101) A61P 37/06 (20180101) Peptides C07K 16/18 (20130101) C07K 16/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153838 | Kochenderfer |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| ASSIGNEE(S) | The United States of America,as represented by the Secretary,Department of Health and Human Services (Bethesda, Maryland) |
| INVENTOR(S) | James N. Kochenderfer (Bethesda, Maryland) |
| ABSTRACT | The invention is directed to a chimeric antigen receptor (CAR) directed against CD19, which comprises an amino acid sequence of any one of SEQ ID NO: 1-SEQ ID NO: 13. The invention also provides T-cells expressing the CAR and methods for destroying malignant B-cells. |
| FILED | Tuesday, December 21, 2021 |
| APPL NO | 17/557845 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Peptides C07K 14/705 (20130101) C07K 14/7051 (20130101) C07K 14/70517 (20130101) C07K 14/70521 (20130101) C07K 14/70535 (20130101) C07K 14/70578 (20130101) C07K 16/2803 (20130101) Original (OR) Class C07K 16/3061 (20130101) C07K 2317/21 (20130101) C07K 2317/70 (20130101) C07K 2317/622 (20130101) C07K 2319/00 (20130101) C07K 2319/02 (20130101) C07K 2319/03 (20130101) C07K 2319/33 (20130101) C07K 2319/74 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153844 | BAWADEKAR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Invenra Inc. (Madison, Wisconsin); Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mandar BAWADEKAR (Verona, Wisconsin); Lucas BAILEY (Suzhou, China PRC); Bryan GLASER (Fitchburg, Wisconsin); Qufei LI (Suzhou, China PRC); Roland GREEN (Madison, Wisconsin); Dileep Kumar PULUKKUNAT (Middleton, Wisconsin); Bonnie HAMMER (Madison, Wisconsin); Daniel Justin GERHARDT (Madison, Wisconsin); Alexander RAKHMILEVICH (Lake Mills, Wisconsin); Paul SONDEL (Madison, Wisconsin) |
| ABSTRACT | Multispecific Treg-binding molecules, constructs, pharmaceutical compositions comprising the constructs, and methods of use thereof are presented. |
| FILED | Wednesday, January 13, 2021 |
| APPL NO | 17/148337 |
| CURRENT CPC | Peptides C07K 16/468 (20130101) C07K 16/2818 (20130101) Original (OR) Class C07K 16/2866 (20130101) C07K 2317/31 (20130101) C07K 2317/56 (20130101) C07K 2317/515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153855 | McGOVERN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cedars-Sinai Medical Center (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dermot McGOVERN (Los Angeles, California); Stephan R. TARGAN (Santa Monica, California); Dalin LI (Walnut, California) |
| ABSTRACT | The aspects disclosed herein describe methods of identifying a subject that is non-responsive to anti-TNF therapy. The aspects disclosed herein further provide for a method of selecting a therapy for a subject with Inflammatory Bowel Disease (IBD), and treating the subject with the therapy. |
| FILED | Friday, October 22, 2021 |
| APPL NO | 17/508128 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/00 (20180101) Peptides C07K 16/2875 (20130101) Original (OR) Class Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6883 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) G01N 33/6863 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153873 | KRAMMER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| INVENTOR(S) | Florian KRAMMER (New York, New York); Teddy John WOHLBOLD (New York, New York); Adolfo GARCIA-SASTRE (New York, New York); Peter PALESE (New York, New York) |
| ABSTRACT | Provided herein are antibodies that bind to neuraminidase (NA) of different strains of influenza B virus, host cells for producing such antibodies, and kits comprising such antibodies. Also provided herein are compositions comprising antibodies that bind to NA of different strains of influenza B virus and methods of using such antibodies to diagnose, prevent or treat influenza virus disease. |
| FILED | Thursday, April 23, 2020 |
| APPL NO | 17/605893 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/215 (20130101) A61K 31/351 (20130101) A61K 31/5383 (20130101) A61K 39/00 (20130101) A61K 47/6871 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/16 (20180101) Peptides C07K 16/40 (20130101) Original (OR) Class C07K 2317/24 (20130101) C07K 2317/51 (20130101) C07K 2317/515 (20130101) C07K 2317/565 (20130101) C07K 2317/622 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154120 | Ebong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eno Essien Ebong (Milton, Massachusetts); Ian Harding (Boston, Massachusetts); Ira M. Herman (Boston, Massachusetts); Abigail N. Koppes (Charlestown, Massachusetts); Alex Caraballo (Silver Spring, Maryland); Nicholas O'Hare (Boston, Massachusetts); Mark Vigliotti (Levittown, Pennsylvania) |
| ABSTRACT | Devices and systems for cell culture analysis are provided. A device for cell culture analysis includes a first component comprising a receptacle configured to receive a cell culture insert having an apical surface and a basal surface and a second component. The device further includes an inlet port disposed at at least one of the first and second components and an outlet port disposed at at least one of the first and second components. The first component and second component are releasably couplable and configured to define a flow path from the inlet port to the outlet port when in a coupled state. The flow path is at least partially defined by a surface of the second component, and the first component is configured to expose the basal surface of the cell culture insert to the flow path. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/454768 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 23/16 (20130101) C12M 23/22 (20130101) C12M 23/38 (20130101) C12M 23/44 (20130101) C12M 23/48 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5088 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154142 | Dietrich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF MIAMI (Miami, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dalton Dietrich (Miami, Florida); Gagani Athauda (Miami, Florida); Mary Bunge (Miami, Florida); James Guest (Miami, Florida); Allan Levi (Miami, Florida); Damien Pearse (Miami, Florida); Patrick Wood (Miami, Florida); Aisha Khan (Miami, Florida) |
| ABSTRACT | The invention provides a method of producing a population of human Schwann cells. The method comprises (a) incubating human fascicles with one or more mitogens for a priming period of three to fourteen days to produce primed fascicles, (b) incubating the primed fascicles with one or more tissue dissociation enzymes to produce primed Schwann cells, (c) culturing the primed Schwann cells at an initial Po density for a period of time to achieve no greater than 90% confluence, (d) expanding the population of Schwann cells by culturing the Schwann cells at an initial passage density for a period of time to achieve no greater than 90% confluence for at least two passages, and harvesting the population of human Schwann cells. The invention further provides an isolated population of Schwann cells obtained by the method described herein. In various aspects of the invention, the isolated population is provided in a composition. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/591100 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/30 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/38 (20130101) A61L 27/383 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0622 (20130101) Original (OR) Class C12N 2501/01 (20130101) C12N 2506/08 (20130101) C12N 2533/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154149 | Cripe et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| ASSIGNEE(S) | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio) |
| INVENTOR(S) | Timothy P. Cripe (Columbus, Ohio); Kevin A. Cassady (Columbus, Ohio); Pin-Yi Wang (c/o Research Institute at Nati, Ohio); Julia K. Halley (Columbus, Ohio) |
| ABSTRACT | The disclosure provides a non-natural herpes simplex virus (“HSV”), compositions comprising, or alternatively consisting essentially of, or yet further consisting of the HSV, and methods of producing the HSV, or infecting a cell with the HSV. Also provided herein are methods of treating cancer or inhibiting the growth or metastasis of cancer cell in a subject in need thereof. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/438877 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/763 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 15/86 (20130101) C12N 2710/00052 (20130101) C12N 2710/16621 (20130101) C12N 2710/16622 (20130101) C12N 2710/16632 (20130101) C12N 2710/16643 (20130101) C12N 2710/16651 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154160 | Dong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Min Dong (Weatogue, Connecticut); Lisheng Peng (Guangzhou, China PRC); Liang Tao (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein is a botulinum neurotoxin (BoNT) polypeptide with a modified receptor binding domain (HC) having one or more amino acid mutations that modify the binding of the BoNT to the receptor. Specific mutations and combinations of mutations are also disclosed. Isolated modified HC, polypeptides comprising the modified HC, chimeric molecules, pharmaceutical compositions, and methods of making and using the same are also disclosed. Methods of identifying additional such modified receptor binding domains, are further disclosed. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/582958 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/33 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/52 (20130101) Original (OR) Class C12N 15/1055 (20130101) Enzymes C12Y 304/24069 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154167 | McKnight |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Oregon (Eugene, Oregon) |
| ASSIGNEE(S) | University of Oregon (Eugene, Oregon) |
| INVENTOR(S) | Jeffrey McKnight (formerly of Eugene, Oregon) |
| ABSTRACT | Compositions and methods for assessing protein function are provided. A modified SpyCatcher protein that can include a tag is provided. Modified SpyCatcher proteins linked to a protein of interest, such as a nuclease are also provided. The methods include contacting a SpyCatcher protein and a SpyTagged protein to form a complex that may further include a protein of interest, one or more nucleic acids, and/or a nuclease. The methods can be used to purify a protein of interest or identify or target a protein binding site in a nucleic acid. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589081 |
| CURRENT CPC | Peptides C07K 14/315 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/102 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154170 | Overbaugh et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| INVENTOR(S) | Julie Overbaugh (Seattle, Washington); Meghan Garrett (Seattle, Washington) |
| ABSTRACT | The current disclosure provides protein residue mapping using a combination of deep mutational scanning and phage display high throughput sequencing. The disclosed methods allow mapping of antibody epitopes and determination of changes in residues of a protein that abolish binding of the protein to a candidate binding molecule. |
| FILED | Friday, February 28, 2020 |
| APPL NO | 17/435610 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1037 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154183 | Kaufman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dan S. Kaufman (La Jolla, California); Davide Bernareggi (La Jolla, California); Jeremy Rich (La Jolla, California); Qi Xie (La Jolla, California); Xiqing Li (La Jolla, California); Briana Prager (La Jolla, California) |
| ABSTRACT | Methods and compositions for increasing tumor cell sensitivity to natural killer cell-mediated toxicity by inhibiting CHMP2A or other endosomal sorting complex required for transport in the tumor cell. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/441189 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4709 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/113 (20130101) Original (OR) Class C12N 2310/14 (20130101) C12N 2310/20 (20170501) C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154190 | Zhao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yangbing Zhao (Lumberton, New Jersey); Jiangtao Ren (Philadelphia, Pennsylvania); Xiaojun Liu (Wallingford, Pennsylvania); Carl H. June (Merion Station, Pennsylvania) |
| ABSTRACT | The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR α chain, TCR β chain, beta-2 microglobulin and FAS further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease. |
| FILED | Tuesday, December 14, 2021 |
| APPL NO | 17/550455 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 35/26 (20130101) A61K 39/001102 (20180801) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 37/06 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/85 (20130101) C12N 15/1138 (20130101) Original (OR) Class C12N 2310/10 (20130101) C12N 2310/20 (20170501) C12N 2501/48 (20130101) C12N 2501/515 (20130101) C12N 2501/599 (20130101) C12N 2501/998 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154204 | TAKAHASHI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yohei TAKAHASHI (San Diego, California); Felix HAUSER (San Diego, California); Julian I. SCHROEDER (La Jolla, California) |
| ABSTRACT | In alternative embodiments, provided are methods for: enhancing drought tolerance of crop plants and trees, enhancing salinity of tolerance of plants such as crop plants, enhancing early monitoring of drought, salinity and cold stress by plants such as crop plants and trees, enhancing stress resistance in plants such as crop plants and trees, by increasing the expression of or the activity of a Raf-like mitogen-activated protein (MAP) kinase kinase (MAPKK) kinase delta B3 family enzyme (or a Raf-like MAPKK kinase delta B3 family enzyme) (a M3K B3 family enzyme) in a plant or a tree cell or a plant or a tree. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 17/437586 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 15/8273 (20130101) Original (OR) Class Enzymes C12Y 207/12002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154208 | Faust et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Joseph E. Rabinowitz (, None); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Susan M. Faust (Philadelphia, Pennsylvania); Joseph E. Rabinowitz (Elkins Park, Pennsylvania); James M. Wilson (Glen Mills, Pennsylvania) |
| ABSTRACT | A CpG-modified recombinant adeno-associated viral (AAV) vector is described. The vector carries a nucleic acid molecule comprising AAV inverted terminal repeat (ITR) sequences and an exogenous gene sequence under the control of regulatory sequences which control expression of the gene product, in which the nucleic acid sequences carried by the vector are modified to significantly reduce CpG di-nucleotides such that an immune response to the vector is reduced as compared to the unmodified AAV vector. Also provided are methods and regimens for delivering transgenes using these AAV viral vectors, in which the innate immune response to the vector and/or transgene is significantly modulated. |
| FILED | Tuesday, May 11, 2021 |
| APPL NO | 17/317560 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 48/0058 (20130101) A61K 48/0075 (20130101) A61K 48/0091 (20130101) Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14141 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154213 | Yan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Iowa Research Foundation (Iowa City, Iowa); University of Kansas (Lawrence, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ziying Yan (Iowa City, Iowa); John F. Engelhardt (Iowa City, Iowa); Jianming Qiu (Overland Park, Kansas); Zekun Wang (Kansas City, Kansas) |
| ABSTRACT | Vectors having a nucleotide sequence having SEQ ID NO:1 or a nucleotide sequence having at least 85% identity to SEQ ID NO:1, or a portion thereof, that is capable of regulating bocaparvovirus replication, or vectors having the complement of the nucleotide sequence, and methods of using the vectors, are provided. |
| FILED | Thursday, September 09, 2021 |
| APPL NO | 17/470560 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/23 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/20 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 15/86 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154219 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan J. Green (Baltimore, Maryland); Stephany Yi Tzeng (Baltimore, Maryland); David Wilson (Baltimore, Maryland); Randall A. Meyer (Baltimore, Maryland) |
| ABSTRACT | Synthetic, biodegradable nanoparticles (NPs) encapsulating at least one of a signal 1 protein, a signal 2 protein, and/or a signal 3 protein are disclosed, which, when transfected into one or more a cancer cells, reprogram the one or more cancer cells into “tumor-derived APCs” in vivo to activate T-cells and natural killer (NK) cells for systemic tumor rejection. The NPs can be used for treating cancers, in particular metastatic cancers. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/441188 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/39 (20130101) A61K 2039/5152 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/88 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154232 | Smolke et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNOR UNIVERSITY (STANFORD, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christina D. Smolke (Menlo Park, California); Catherine Thodey (Mountain View, California); Isis Trenchard (Redwood City, California); Stephanie Galanie (Palo Alto, California) |
| ABSTRACT | Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512451 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0073 (20130101) C12N 9/1007 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/18 (20130101) C12P 17/182 (20130101) Original (OR) Class Enzymes C12Y 121/03003 (20130101) C12Y 201/0114 (20130101) C12Y 201/01116 (20130101) C12Y 201/01128 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154237 | Liu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Lexington, Massachusetts); David Irby Bryson, JR. (Dorchester, Massachusetts) |
| ABSTRACT | The disclosure provides amino acid sequence variants of orthogonal aminoacyl-tRNA synthetases (AARSs) having increased activity and selectivity compared to previous AARSs, and methods of producing the same. |
| FILED | Tuesday, July 03, 2018 |
| APPL NO | 16/628456 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154248 | Abate et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adam R. Abate (Daly City, California); David Sukovich (San Francisco, California) |
| ABSTRACT | The methods and systems described herein provide an improved emulsion droplet based nucleic acid amplification method, which allows nucleic acids contained in biological systems to be detected, quantitated and/or sorted based on their sequence as detected with nucleic acid amplification techniques, e.g., polymerase chain reaction (PCR). The nucleic acids can be free floating or contained within living or nonliving structures, including particles, viruses, and cells. The nucleic acids can include, e.g., DNA or RNA. |
| FILED | Thursday, September 09, 2021 |
| APPL NO | 17/470523 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 7/52 (20130101) Apparatus for Enzymology or Microbiology; C12M 3/00 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/34 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/68 (20130101) C12Q 1/686 (20130101) Original (OR) Class C12Q 1/6806 (20130101) C12Q 1/6818 (20130101) C12Q 1/6844 (20130101) C12Q 1/6886 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220154255 — METHODS AND SYSTEMS FOR DETERMINING SPATIAL PATTERNS OF BIOLOGICAL TARGETS IN A SAMPLE
| US 20220154255 | CHEE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| ASSIGNEE(S) | Prognosys Biosciences, Inc. (San Diego, California) |
| INVENTOR(S) | Mark S. CHEE (San Diego, California); David A. ROUTENBERG (San Diego, California) |
| ABSTRACT | The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667045 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5027 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6809 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154258 | Gootenberg et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| ASSIGNEE(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); MASSACHUSETTS INSTITUTE OF TECHNOLOGY (Cambridge, Massachusetts); PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Massachusetts) |
| INVENTOR(S) | Jonathan Gootenberg (Cambridge, Massachusetts); Omar Abudayyeh (Cambridge, Massachusetts); Feng Zhang (Cambridge, Massachusetts) |
| ABSTRACT | Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences, including multiplex lateral flow diagnostic devices and methods of use, are provided. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/439063 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/5023 (20130101) B01L 2300/0825 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/14 (20130101) C12N 9/22 (20130101) C12N 15/11 (20130101) C12N 2310/20 (20170501) C12N 2320/11 (20130101) C12N 2330/31 (20130101) C12N 2800/80 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6825 (20130101) Original (OR) Class Enzymes C12Y 306/04012 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/6428 (20130101) G01N 2021/6432 (20130101) G01N 2021/6439 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/30 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154280 | PROCHOWNIK et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Edward Victor PROCHOWNIK (Pittsburgh, Pennsylvania); James Matthew DOLEZAL (Chicago, Illinois); UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGER EDUCATION (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Victor PROCHOWNIK (Pittsburgh, Pennsylvania); James Matthew DOLEZAL (Chicago, Illinois) |
| ABSTRACT | Disclosed herein t-SNE-assisted clustering revealed that the expression of certain cancer pathway transcripts are correlated with certain cancer types. In one aspect, disclosed herein are methods for diagnosis and prognosis of a cancer using cancer pathway transcript expression. |
| FILED | Friday, January 17, 2020 |
| APPL NO | 17/423648 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/118 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154282 | Regev et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Boston, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Aviv Regev (Cambridge, Massachusetts); Livnat Jerby-Arnon (Cambridge, Massachusetts); Mario Suva (Boston, Massachusetts); Nicolo Riggi (Boston, Massachusetts) |
| ABSTRACT | The present invention provides novel compositions and methods based on the discovery of the mechanisms and gene expression programs associated with synovial sarcoma. In particular, core oncogenic programs were expressed by a distinct subpopulation of malignant cells and associated with poor clinical outcome, a cell cycle program distinguished cycling from non-cycling cells, with cycling cells having a tendency to be poorly differentiated and indicative of increased risk of metastatic disease, and a (de)differentiation program that can identify poorly differentiated cells, the absence of which was prognostic of metastasis free survival. Methods of treatment include use of HDAC and CDK4/6 inhibitors to block oncogenic program to selectively target synovial sarcoma cells. Finally, macrophages and T cells can mimic the effect of SS18-SSX inhibition by secreting TNFa and IFNg, which allows for adoptive cell therapy to provide cells with increased expression of TNFa and IFNg. |
| FILED | Thursday, March 12, 2020 |
| APPL NO | 17/438051 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154294 | Markowitz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanford D. Markowitz (Pepper Pike, Ohio); Helen Moinova (Beachwood, Ohio); Amitabh Chak (University Heights, Ohio); Joseph Willis (Shaker Heights, Ohio); Thomas LaFramboise (Shaker Heights, Ohio) |
| ABSTRACT | The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/590986 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6827 (20130101) C12Q 1/6853 (20130101) C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/574 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154295 | Velculescu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Victor Velculescu (Baltimore, Maryland); Valsamo Anagnostou (Baltimore, Maryland); Noushin Niknafs Kermani (Baltimore, Maryland) |
| ABSTRACT | This document relates to methods and materials involved in assessing and/or treating a mammal having a cancer. For example, methods and materials provided herein can be used to determine the corrected tumor mutation burden (cTMB) of one or more cells (e.g., one or more cancer cells) from a mammal having cancer, thereby identifying the cancer as being likely to respond to a particular cancer treatment (e.g., a cancer immunotherapy). This document also provides methods and materials for treating a mammal identified as having a cancer likely to respond to a particular cancer treatment. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 17/598690 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/3955 (20130101) A61K 45/06 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) Original (OR) Class C12Q 2600/16 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155190 | Hildebrand et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | David Grant Colburn Hildebrand (Cambridge, Massachusetts); Brett Jesse Graham (Cambridge, Massachusetts); Wei-Chung Allen Lee (Cambridge, Massachusetts) |
| ABSTRACT | A tape for collecting tissue samples in a manner compatible with imaging in a transmission electron microscopy (TEM) system, includes a tape substrate having two side walls forming a trough. The trough is defined by a bottom surface of the tape substrate and internal surfaces of the side walls, with an open side therebetween. A support film is attached to a top surface of the tape substrate, and a plurality of apertures is spaced at predetermined locations along the length of the tape substrate, each aperture being covered by the support film. The tape includes a stacked configuration in which the tape substrate is wound in layers, the bottom surfaces of the side walls in one layer being in contact with the support film in an immediately adjacent layer. The apertures in the second layer are aligned within the trough of the first layer, between the side walls. |
| FILED | Thursday, January 27, 2022 |
| APPL NO | 17/586727 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/36 (20130101) Original (OR) Class G01N 35/00009 (20130101) G01N 2001/362 (20130101) Electric Discharge Tubes or Discharge Lamps H01J 37/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155251 | Pamula et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Advanced Liquid Logic, Inc. (San Diego, California); Duke University (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vamsee K. Pamula (Cary, North Carolina); Vijay Srinivasan (Cary, North Carolina); Michael G. Pollack (Durham, North Carolina); Richard B. Fair (Durham, North Carolina) |
| ABSTRACT | The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet microactuator including a droplet including one or more beads and immobilizing at least one of the one or more beads. The method further includes conducting one or more droplet operations to divide the droplet to yield a set of droplets including a droplet including the one or more immobilized beads and a droplet substantially lacking the one or more immobilized beads. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/649842 |
| CURRENT CPC | Mixing, e.g Dissolving, Emulsifying, Dispersing B01F 33/3021 (20220101) B01F 33/3031 (20220101) Chemical or Physical Laboratory Apparatus for General Use B01L 3/0268 (20130101) B01L 3/502715 (20130101) B01L 3/502723 (20130101) B01L 3/502761 (20130101) B01L 3/502784 (20130101) B01L 3/502792 (20130101) B01L 7/525 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6869 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/26 (20130101) Original (OR) Class G01N 27/416 (20130101) G01N 27/447 (20130101) G01N 27/3271 (20130101) G01N 35/00029 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155301 | Leung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Jewish Health (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Donald Y.M. Leung (Denver, Colorado); Elena Goleva (Denver, Colorado); Lingbo Li (Denver, Colorado) |
| ABSTRACT | The present invention is directed toward novel methods to identify as well as to treat a subject having an inflammatory disease resistant to corticosteroids. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529700 |
| CURRENT CPC | Peptides C07K 16/40 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1137 (20130101) C12N 2310/14 (20130101) C12N 2320/30 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/485 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) Original (OR) Class G01N 2333/91205 (20130101) G01N 2333/91215 (20130101) G01N 2800/52 (20130101) G01N 2800/122 (20130101) G01N 2800/7095 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155306 | Lane et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Kentucky Research Foundation (Lexington, Kentucky) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew N. Lane (Lexington, Kentucky); Teresa W. Fan (Lexington, Kentucky); Richard M. Higashi (Lexington, Kentucky) |
| ABSTRACT | Provided herein are methods of detecting lipids in humans suspected of having cancer, in particular detecting lipids in samples from a human suspected of having breast or lung cancer. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/592763 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57415 (20130101) G01N 33/57423 (20130101) G01N 33/57488 (20130101) Original (OR) Class G01N 2405/02 (20130101) G01N 2405/04 (20130101) G01N 2405/06 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 5/00 (20190201) G16B 5/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155322 | Sangaralingham et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sasantha J. Sangaralingham (Rochester, Minnesota); Yang Chen (Rochester, Minnesota); John C. Burnett, Jr. (Rochester, Minnesota) |
| ABSTRACT | This document provides methods and materials related to using natriuretic peptides (NPs) as markers for acute kidney injury (AKI), and methods and materials for using NPs to treat patients identified as having, or being likely to have, AKI. |
| FILED | Friday, March 06, 2020 |
| APPL NO | 17/433012 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2333/58 (20130101) G01N 2800/347 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220155391 — MAGNETIC RESONANCE IMAGER WITH COILS FOR ARBITRARY IMAGE SPACE AND FABRICATION THEREOF
| US 20220155391 | Juchem et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christoph Juchem (Ridgefield, Connecticut); Michael Sebastian Theilenberg (New York, New York); Yun Shang (New York, New York); Jalal Ghazouani (Hamburg, Germany) |
| ABSTRACT | An apparatus for fabricating non-planar coils includes a rotating table driven by a first motor; a wire approach height adjustment arm driven by a second motor; and a synchronization module configured such that a wire traversing from the height adjustment arm to a bobbin on the rotating table passes into a non-planar groove cut in the bobbin without damaging the wire. Performing magnetic resonance (MR) measurements includes a plurality of coil units configured for generating a gradient or shim magnetic field. The coil unit includes a plurality of coil windings, and each coil winding is separated longitudinally from an adjacent coil winding. A single pair of electrically conducting leads is configured to cause current to flow through all of the plurality of coil windings in the coil unit. Techniques include methods to fabricate and operate the apparatus. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/649462 |
| CURRENT CPC | Measuring Electric Variables; Measuring Magnetic Variables G01R 33/3856 (20130101) G01R 33/3858 (20130101) Original (OR) Class G01R 33/3875 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155584 | Li et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Haijun Li (Ann Arbor, Michigan); Thomas D Wang (Ann Arbor, Michigan) |
| ABSTRACT | A scanning assembly for an optical instrument includes a reflector and a folded-beam spring assembly coupled to the reflector for deflecting the reflector for beam scanning. A lever suspension assembly is coupled to the folded-beam spring assembly and provides torsional movement of the reflector for beam scanning over a two-dimensional region, allowing for large total scan angles and large vertical displacements. |
| FILED | Wednesday, March 18, 2020 |
| APPL NO | 17/439728 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/00172 (20130101) Microstructural Devices or Systems, e.g Micromechanical Devices B81B 3/0043 (20130101) B81B 2201/042 (20130101) B81B 2203/04 (20130101) B81B 2203/053 (20130101) B81B 2203/058 (20130101) B81B 2203/0136 (20130101) B81B 2203/0163 (20130101) Optical Elements, Systems, or Apparatus G02B 26/101 (20130101) Original (OR) Class G02B 26/0841 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220156903 | McCall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | SPECTRAL MD, INC. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian McCall (Dallas, Texas); Wensheng Fan (Plano, Texas); Jason Dwight (Dallas, Texas); Zhicun Gao (Plano, Texas); Jeffrey E. Thatcher (Irving, Texas); John Michael DiMaio (Dallas, Texas) |
| ABSTRACT | Generally described, one or more aspects of the present application correspond to systems and techniques for spectral imaging using a multi-aperture system with curved multi-bandpass filters positioned over each aperture. The present disclosure further relates to techniques for implementing spectral unmixing and image registration to generate a spectral datacube using image information received from such imaging systems. Aspects of the present disclosure relate to using such a datacube to analyze the imaged object, for example to analyze tissue in a clinical setting, perform biometric recognition, or perform materials analysis. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/455856 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 7/0012 (20130101) G06T 7/33 (20170101) G06T 7/55 (20170101) G06T 7/62 (20170101) G06T 2207/10036 (20130101) G06T 2207/10144 (20130101) G06T 2207/20221 (20130101) Pictorial Communication, e.g Television H04N 5/265 (20130101) H04N 5/2254 (20130101) H04N 5/2256 (20130101) H04N 5/2356 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220156941 | HE et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Yufan HE (Baltimore, Maryland); Jerry L. PRINCE (Baltimore, Maryland); Aaron CARASS (Towson, Maryland) |
| ABSTRACT | A device receives a two-dimensional (2-D) image that depicts a cross-sectional view of a macula comprised of layers and boundaries to segment the layers, and determines spatial coordinates of the 2-D image that include x-coordinates and y-coordinates. The device uses a data model, that has been trained using a deep learning technique, to process the 2-D image and the spatial coordinates to generate boundary maps that indicate likelihoods of voxels of the 2-D image being in positions that are part of particular boundaries. The device determines, by analyzing the boundary maps, an initial set of boundary positions, and determines a final set of boundary positions by using a topological order identification technique to refine the initial set of boundary positions. The device determines the thickness levels of the layers of the macula based on the final set of boundary positions, and performs one or more actions based on the thickness levels. |
| FILED | Wednesday, March 25, 2020 |
| APPL NO | 17/594191 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 3/12 (20130101) A61B 3/0025 (20130101) A61B 3/0058 (20130101) A61B 3/1005 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) Image Data Processing or Generation, in General G06T 7/11 (20170101) Original (OR) Class G06T 7/0012 (20130101) G06T 7/12 (20170101) G06T 7/73 (20170101) G06T 7/143 (20170101) G06T 2207/10101 (20130101) G06T 2207/20076 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30041 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/10 (20180101) G16H 70/60 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220157436 | Harley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zeriscope, Inc. (Mount Pleasant, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William G. Harley (Mount Pleasant, South Carolina); Ronald Ettore Acierno (Houston, Texas) |
| ABSTRACT | A multimodal data acquisition and communication system and method for distributed management of transdiagnostic behavioral therapy (TBT). An exemplary system, method, and apparatus according to certain aspects of the present disclosure may include a patient interface comprising (a) one or more sensors configured to collect quantitative (e.g., physiological data) and qualitative data (e.g., video/audio data) from a patient user during a TBT session, and (b) a mobile computing device, such as a smartphone, comprising a mobile software application configured to establish a data transfer interface with the one or more sensors and provide a graphical user interface to the patient user. The mobile computing device may be communicatively engaged with a cloud-based server over a wireless communications network to enable real-time collection, communication, storage and analysis of TBT data and bi-directional audio/video communication with at least one clinician client device. |
| FILED | Tuesday, December 07, 2021 |
| APPL NO | 17/544561 |
| CURRENT CPC | Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/70 (20180101) Original (OR) Class G16H 40/67 (20180101) G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220157442 | Ning et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xia Ning (Columbus, Ohio); Zhiyun Ren (Sunnyvale, California); Bo Peng (Columbus, Ohio); Titus K. Schleyer (Indianapolis, Indiana) |
| ABSTRACT | Disclosed embodiments include computer-implemented methods and systems that can efficiently generate highly relevant recommended search terms to clinicians. A hybrid collaborative filtering model recommends search terms for a specific patient to the clinician. The model draws on information from patients' clinical encounters and the searches that were performed during the clinical encounters. To generate recommendations, the model uses search terms which are (1) frequently co-occurring with the ICD codes recorded for the patient and (2) highly relevant to the most recent search terms. One variation of the model uses only the most recent ICD codes assigned to the patient. Another variation uses all ICD codes. Comprehensive experiments of embodiments of the methods and systems have demonstrate high levels of performance. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526591 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/24578 (20190101) G06F 17/16 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/20 (20180101) Original (OR) Class G16H 70/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220151163 | Agrawal et al. |
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| FUNDED BY |
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| APPLICANT(S) | Rakesh Agrawal (West Lafayette, Indiana); Muhammad Alam (West Lafayette, Indiana); Michell Tuinstra (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rakesh Agrawal (West Lafayette, Indiana); Muhammad Alam (West Lafayette, Indiana); Michell Tuinstra (West Lafayette, Indiana) |
| ABSTRACT | A method and apparatus for generating solar power in agricultural fields while minimally impacting crop growth and farming efforts, including positioning an elongated solar panel above crops, wherein the elongated solar panel runs generally parallel to longitudinal lines and wherein the elongated solar panel has at least one solar transducing face and an endless edge surrounding and perpendicular to the at least one solar transducing face, automatically pivoting the elongated solar panel such that the at least one solar transducing face is oriented parallel to incident solar rays during predetermined times when plant growth requires incident sunlight, automatically pivoting the elongated solar panel such that the at least one solar transducing face is oriented parallel to the vertical during rain, automatically pivoting the elongated solar panel out of the way of heavy farm equipment, and automatically pivoting the elongated solar panel such that the at least one solar transducing face is oriented perpendicular to incident solar rays at predetermined times when plant growth does not require direct sunlight. The elongated solar panel is positioned sufficiently above crops to give clearance to heavy farm equipment passing therebelow and/or adjacent panels are spaced sufficiently apart such that heavy farm equipment may pass therebetween. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/474003 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 9/243 (20130101) Original (OR) Class Generation of Electric Power by Conversion of Infra-red Radiation, Visible Light or Ultraviolet Light, e.g Using Photovoltaic [PV] Modules H02S 20/10 (20141201) H02S 20/32 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151509 | ODAME et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF DARTMOUTH COLLEGE (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kofi ODAME (Hanover, New Hampshire); Justice AMOH (Hanover, New Hampshire) |
| ABSTRACT | A system adapted to assisting patients manage asthma includes a wearable sensor for detection of asthma symptoms and inhaler use, having a microphone capable of generating an electrical signal indicative of asthma symptoms or inhaler use; a processor with firmware adapted to process the electrical signal to determine potential asthma symptoms and inhaler use; and store the electrical signal in the memory when the electrical signal potentially corresponds asthma symptoms or inhaler use. In particular embodiments, the system includes an electronic asthma diary including detected asthma symptoms and detected inhaler usage, both with timestamps, and a prescribed treatment protocol. Protocol firmware processes detected asthma symptoms an inhaler usage recorded in the asthma diary to determine if asthma is controlled, and if asthma is not determined controlled determines if a treatment change is authorized; if treatment change is authorized the treatment change is displayed in human-readable form. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532983 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/087 (20130101) A61B 5/486 (20130101) A61B 5/725 (20130101) A61B 5/0823 (20130101) Original (OR) Class A61B 5/6822 (20130101) A61B 5/6823 (20130101) A61B 5/7207 (20130101) A61B 7/003 (20130101) A61B 2562/0204 (20130101) A61B 2562/0219 (20130101) A61B 2562/0247 (20130101) A61B 2562/0261 (20130101) Electric Digital Data Processing G06F 16/22 (20190101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 10/60 (20180101) G16H 20/10 (20180101) G16H 40/67 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151545 | Mansfield et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Mansfield (Santa Cruz, California); Katia Obraczka (Santa Cruz, California) |
| ABSTRACT | Techniques for patient pressure injury prevention (PPIP) include receiving, from a plurality of pressure sensors configured to be disposed in a spatial arrangement in contact with a patient, samples that indicate pressure measurements by the plurality of sensors at each of a plurality of different times. At each of the plurality of different times an angular orientation of the pressure is determined based on the samples. A change in the angular orientation of the pressure is determined at each successive time of the plurality of different times. A value of a patient movement parameter is determined based on the change in angular orientation of the pressure. A pressure injury category for the patient based on the value of the patient movement parameter is presented on a display device for a caregiver. Treatment of the patient by the caregiver is based on the pressure injury category. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/455332 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/445 (20130101) Original (OR) Class A61B 5/742 (20130101) A61B 5/1116 (20130101) A61B 5/6813 (20130101) A61B 2562/046 (20130101) A61B 2562/0247 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152128 | Moran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nancy A. Moran (Austin, Texas); Sean Leonard (Austin, Texas); Waldan Kwong (Vancouver, Canada); Jenkyn Elijah Powell (Austin, Texas) |
| ABSTRACT | Provided herein are defined bacterial co-cultures, and methods of generating the same. Further provided are methods of using the defined bacterial co-cultures as probiotics to prevent diseases or disorders in bees and bee colonies. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 17/431813 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/741 (20130101) A61K 35/745 (20130101) A61K 35/747 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152274 | Lee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Massachusetts (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jungwoo Lee (Boston, Massachusetts); Jaehyuck Shim (Boston, Massachusetts); Ryan Carpenter (Boston, Massachusetts); Yongkuk Park (Boston, Massachusetts); Jun-Goo Kwak (Boston, Massachusetts) |
| ABSTRACT | Disclosed herein are three-dimensional bone tissue grafts produced from stacked demineralized bone paper. Also disclosed are methods for treating a subject using tissue grafts produced from the disclosed demineralized bone paper. Also disclosed are assay systems that involves culturing bone-promoting cells on the disclosed demineralized bone paper. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531328 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/3608 (20130101) Original (OR) Class A61L 27/3683 (20130101) A61L 2300/414 (20130101) A61L 2430/02 (20130101) Apparatus for Enzymology or Microbiology; C12M 23/12 (20130101) C12M 23/22 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0669 (20130101) C12N 2527/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/2813 (20130101) G01N 33/4833 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152676 | Meduri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Texas Tech University System (Lubbock, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Chandra Sekhar Meduri (Lubbock, Texas); Zhonglue Hu (Lubbock, Texas); Golden Kumar (Lubbock, Texas); Jerzy Blawzdziewicz (Lubbock, Texas); Harvinder Singh Gill (Lubbock, Texas) |
| ABSTRACT | Embossing of metallic glass supercooled liquids into templates is emerging as a precision net-shaping and surface patterning technique for metals. Here, the effect of thickness of metallic glass on template-based embossing is disclosed. The results show that the existing embossing theory developed for thick samples fails to describe the process when the thickness of metallic glass becomes comparable to the template cavity diameter. Increased flow resistance at the cavity entrance results in viscous buckling of supercooled liquid instead of filling. A new phenomenological equation is proposed to describe the thickness dependent filling of template cavities. The buckling phenomenon is analyzed based on the folding model of multilayer viscous media. Controlled buckling can be harnessed in fabrication of metal microtubes, which are desirable for many emerging applications. |
| FILED | Wednesday, March 18, 2020 |
| APPL NO | 17/439042 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 1/22 (20130101) Original (OR) Class B21C 9/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152837 | Das et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| ASSIGNEE(S) | University of Louisville Research Foundation, Inc. (Louisville, Kentucky) |
| INVENTOR(S) | Sumit Kumar Das (Louisville, Kentucky); Mohammad Nasser Saadatzi (Louisville, Kentucky); Indika B. Wijayasinghe (Louisville, Kentucky); Shamsudeen Olawale Abubakar (Louisville, Kentucky); Christopher Kevin Robinson (Louisville, Kentucky); Dan O. Popa (Louisville, Kentucky) |
| ABSTRACT | This specification describes an adaptive robotic nursing assistant for physical tasks and patient observation and feedback. In some examples, the adaptive robotic nursing assistant includes an omni-directional mobile platform; a footrest on the omni-directional mobile platform; a handlebar located above the footrest such that a user standing on the footrest can grasp the handlebar; a display above the handlebar and at least one user input device; a robot manipulator comprising a robotic arm and an end effector on the robotic arm; and a control system coupled to the omni-directional mobile platform, the control system comprising at least one processor and memory storing executable instructions for the at least one processor to control the omni-directional mobile platform. |
| FILED | Thursday, April 16, 2020 |
| APPL NO | 17/604035 |
| CURRENT CPC | Transport, Personal Conveyances, or Accommodation Specially Adapted for Patients or Disabled Persons; Operating Tables or Chairs; Chairs for Dentistry; Funeral Devices A61G 12/00 (20130101) Physical Therapy Apparatus, e.g Devices for Locating or Stimulating Reflex Points in the Body; Artificial Respiration; Massage; Bathing Devices for Special Therapeutic or Hygienic Purposes or Specific Parts of the Body A61H 3/04 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 2/10 (20130101) A61L 2/18 (20130101) Manipulators; Chambers Provided With Manipulation Devices B25J 5/007 (20130101) B25J 11/009 (20130101) Original (OR) Class B25J 13/065 (20130101) B25J 13/085 (20130101) Vehicle Wheels; Castors; Axles for Wheels or Castors; Increasing Wheel Adhesion B60B 19/003 (20130101) Arrangement or Mounting of Propulsion Units or of Transmissions in Vehicles; Arrangement or Mounting of Plural Diverse Prime-movers in Vehicles; Auxiliary Drives for Vehicles; Instrumentation or Dashboards for Vehicles; Arrangements in Connection With Cooling, Air Intake, Gas Exhaust or Fuel Supply of Propulsion Units in Vehicles B60K 1/02 (20130101) Motor Vehicles; Trailers B62D 51/02 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/021 (20130101) G05D 2201/0206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153061 | Gonella et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| ASSIGNEE(S) | Regents of the University of Minnesota (Minneapolis, Minnesota) |
| INVENTOR(S) | Stefano Gonella (Saint Paul, Minnesota); William Zunker (Verona, Wisconsin) |
| ABSTRACT | A non-pneumatic tire defining axial, radial, and circumferential directions. The tire includes an annular lattice structure extending radially between an inner circumferential edge and an outer circumferential edge. The lattice structure exhibits topological polarization, with the inner circumferential edge being stiffer than the outer circumferential edge. The topological polarization includes asymmetry in mechanical response to opposing forces applied to the inner and outer circumferential edges. The lattice structure which provides topological polarization endows the tire with localized softness along the outer radius, which enables extreme absorption of asperities, without transferring significant forces to the axle. In some embodiments, the lattice structure further exhibits topological protection, including the topological polarization characteristics being maintained upon experiencing wear at the outer circumferential edge. In some embodiments, the lattice structure is, or is akin to, a Kagome lattice arrangement. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/527637 |
| CURRENT CPC | Vehicle Tyres Tyre Inflation; Tyre Changing or Repairing; Repairing, or Connecting Valves To, Inflatable Elastic Bodies in General; Devices or Arrangements Related to Tyres B60C 7/107 (20210801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153069 | Heo et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (DENTON, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hyeonu Heo (Denton, Texas); Arup Neogi (Denton, Texas) |
| ABSTRACT | The disclosure relates to a road noise reducing system including a wheel rim having a barrel, a first layer of acoustic metamaterial with a first plurality of open cells mounted on the barrel, and, optionally, a second layer of acoustic metamaterial with a second plurality of open cells in contact with the first layer of acoustic metamaterial. The system optionally includes a pneumatic tire with a hollow, wherein the tire is mounted on the wheel rim such that the hollow forms a closed cavity and can incorporate additional elements including an elastomeric membrane, a noise-absorbing foam, and/or a resonator. The system has a sound transmission loss of at least 20-35 dB at frequencies of 50 Hz to 2,000 Hz and can reduce tire-road interaction noise by at least 50-70%. Also disclosed are methods of making road noise reducing wheel and tire assemblies, automobiles incorporating the same, and methods for reducing tire-road interaction noise. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/454869 |
| CURRENT CPC | Vehicle Tyres Tyre Inflation; Tyre Changing or Repairing; Repairing, or Connecting Valves To, Inflatable Elastic Bodies in General; Devices or Arrangements Related to Tyres B60C 5/002 (20130101) B60C 19/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153589 | Nel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California); Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Andre E. Nel (Sherman Oaks, California); Tian Xia (Los Angeles, California); Ruibin Li (Los Angeles, California); Mark C. Hersam (Wilmette, Illinois); Nikhita D. Mansukhani (Allston, Massachusetts); Linda Guiney (Chicago, Illinois) |
| ABSTRACT | In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (.C) density. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531651 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 43/90 (20130101) A01N 59/00 (20130101) Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 27/08 (20130101) Non-metallic Elements; Compounds Thereof; C01B 32/198 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153596 | Turker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Melik Z. Turker (Princeton, New Jersey); Thomas C. Gardinier (Raritan, New Jersey); Ulrich B. Wiesner (Ithaca, New York); Kai Ma (Belle Mead, New Jersey) |
| ABSTRACT | Silica nanorings, methods of making silica nanorings, and uses of silica nanorings. The silica nanorings may be PEGylated. The silica nanorings may be surface functionalized, which may be surface selective functionalization, with one or more polyethylene glycol (PEG) group(s), one or more display group(s), one or more functional group(s), or a combination thereof. The silica nanorings may have a size of 5 to 20 nm. The silica nanorings may be made using micelles. The absence or presence of the micelles during PEGylation and/or functionalization allows for surface selective functionalization. The silica nanorings may be used in various diagnostic and/or treatment methods. |
| FILED | Friday, August 27, 2021 |
| APPL NO | 17/459562 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/51 (20130101) A61K 33/00 (20130101) A61K 49/005 (20130101) A61K 51/1244 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/124 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153656 | Flanders et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Opus 12 Incorporated (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas H. Flanders (San Francisco, California); Kendra P. Kuhl (Oakland, California); Etosha R. Cave (Berkeley, California); Sichao Ma (Dublin, California); Ziyang Huo (Moraga, California); Carter S. Haines (Berkeley, California); Timothy A. Bekkedahl (Sunnyvale, California); Kathryn L. Corp (Berkeley, California); Ashley D. Mishra (Danville, California); Edward Izett (Berkeley, California); Luka Stevic (Berkeley, California) |
| ABSTRACT | A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/452395 |
| CURRENT CPC | Separation B01D 53/18 (20130101) B01D 53/229 (20130101) B01D 53/1475 (20130101) B01D 53/1493 (20130101) B01D 2252/30 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/34 (20130101) C01B 3/503 (20130101) C01B 2203/062 (20130101) C01B 2203/0216 (20130101) C01B 2203/0405 (20130101) Acyclic or Carbocyclic Compounds C07C 1/0485 (20130101) Original (OR) Class C07C 4/02 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) C25B 9/23 (20210101) C25B 15/081 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153778 | MANZER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Cornell University (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zachary MANZER (Ithaca, New York); Surajit GHOSH (Ithaca, New York); Susan DANIEL (Ithaca, New York) |
| ABSTRACT | The invention relates to hybrid supported lipid bilayer (HSLB) including a phospholipid; a copolymer; and a membrane protein, wherein the membrane protein is functional, properly oriented within the lipid bilayer, and mobile within the lipid bilayer. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526327 |
| CURRENT CPC | Peptides C07K 1/082 (20130101) Original (OR) Class C07K 17/02 (20130101) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 8/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153779 | Francis et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matthew B. Francis (Berkeley, California); Marco Jackson Lobba (Berkeley, California); Johnathan Charles Maza (Berkeley, California); Alan M. Marmelstein (Berkeley, California); Jennifer A. Doudna (Berkeley, California); Christof Fellmann (San Francisco, California); Casey S. Mogilevsky (Berkeley, California) |
| ABSTRACT | The present disclosure provides a method for chemoselective modification of a target molecule. A subject method includes contacting a target molecule comprising a thiol moiety with a biomolecule comprising a reactive moiety, wherein the reactive moiety is generated by reaction of a biomolecule comprising a phenol moiety or a catechol with an enzyme capable of oxidizing the phenol or the catechol moiety. The contacting is carried out under conditions sufficient for conjugation of the target molecule to the biomolecule, thereby producing a modified target molecule. The present disclosure provides compositions comprising a subject target molecule comprising a thiol moiety, and a biomolecule comprising a phenol moiety or a catechol moiety. The present disclosure provides kits for carrying out a subject method. The present disclosure also provides modified target molecules and methods for using same. |
| FILED | Thursday, March 19, 2020 |
| APPL NO | 17/440129 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/54 (20170801) A61K 47/64 (20170801) A61K 47/65 (20170801) Peptides C07K 1/113 (20130101) C07K 1/1072 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153931 | Fors et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brett P. Fors (Ithaca, New York); Héctor D. Abruña (Ithaca, New York); Cara Gannett (Cicero, New York); Brian Peterson (Ithaca, New York); Luxi Shen (Stoneham, Massachusetts) |
| ABSTRACT | Provided are phenazine copolymers and methods of making and using phenazine copolymers. The phenazine copolymers may be made from one or more phenazine precursors and one or more co-monomer precursors, one or more phenazine precursors and one or more cross-linking precursors, or one or more phenazine precursors and both one or more cross-linking precursors and one or more co-monomer precursors. The phenazine copolymers may be used in/on cathodes. The cathodes may be used in a variety of devices, such as, for example, batteries or supercapacitors. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 17/599328 |
| CURRENT CPC | Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 73/0694 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/18 (20130101) Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 51/0035 (20130101) H01L 51/5221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153952 | Hess et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew J. Hess (Louisville, Colorado); Qingkun Liu (Boulder, Colorado); Ivan I. Smalyukh (Boulder, Colorado) |
| ABSTRACT | Disclosed are cellulose-based flexible gels containing cellulose nanorods, ribbons, fibers, and the like, and cellulose-enabled inorganic or polymeric composites, wherein the gels have tunable optical, heat transfer, and stiffness properties. The disclosed gels are in the form of hydrogels, organogels, liquid-crystal (LC) gels, and aerogels, depending on the solvents in the gels. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532889 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 9/28 (20130101) C08J 9/35 (20130101) Original (OR) Class C08J 9/0061 (20130101) Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154125 | Van Wie et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Washington State University (Pullman, Washington) |
| ASSIGNEE(S) | Washington State University (Pullman, Washington) |
| INVENTOR(S) | Bernard J. Van Wie (Pullman, Washington); Kitana M. Kaiphanliam (Pullman, Washington); Brenden Fraser-Hevlin (Pullman, Washington); Eric S. Barrow (Pullman, Washington) |
| ABSTRACT | A centrifugal bioreactor includes a turntable assembly, an electric motor coupled to the turntable assembly, and a replaceable rotor assembly coupled to the turntable assembly. The replaceable rotor assembly includes a plurality of reaction chambers that house cell cultures. A fresh medium tank holds fresh medium for the cell cultures, a spent medium tank holds a first portion of spent medium produced by the cell cultures, and an inoculation tank combines the fresh medium from the fresh medium tank and a second portion of the spent medium. A gas exchanger exposes the fresh medium and the second portion of the spent medium to gas. Additionally, a first pump supplies the fresh medium and the second portion of the spent medium to the plurality of the reaction chambers, and a second pump discard the first portion of the spent medium to the spent medium tank. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/527926 |
| CURRENT CPC | Apparatus for Enzymology or Microbiology; C12M 27/10 (20130101) Original (OR) Class C12M 29/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154146 | O'CONNOR et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Administrators of the Tulane Educational Fund (New Orleans, Louisiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kim C. O'CONNOR (New Orleans, Louisiana); Sean D. MADSEN (Seattle, Washington); Bruce A. BUNNELL (Mandeville, Louisiana) |
| ABSTRACT | Methods of improving the in vivo survival of mesencymal stem cells are described. The method comprising the steps of: a) selecting, from a heterogeneous group of MSCs, MSCs having high expression of NG2; b) expanding the MSCs selected in step a); c) attaching the MSCs expanded in step b) to a scaffold; and d) implanting the scaffold with the MSCs in a mammal. |
| FILED | Wednesday, March 18, 2020 |
| APPL NO | 17/440654 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/28 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0663 (20130101) Original (OR) Class C12N 2533/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154199 | Dixon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (Denton, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A. Dixon (Sulphur, Oklahoma); Fang Chen (Denton, Texas); Chunliu Zhuo (Denton, Texas) |
| ABSTRACT | The disclosure provides recombinant LAC polynucleotides encoding a laccase (LAC) polypeptide capable of polymerizing caffeyl alcohol, vectors and cells including the recombinant LAC polynucleotide. The disclosure also provides transgenic plants including cells having the recombinant LAC polynucleotide of the present disclosure and methods of increasing production of C-lignin in a plant. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528375 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8218 (20130101) C12N 15/8255 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154202 | Stacey et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators of the University of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Minviluz Stacey (Columbia, Missouri); Cuong X. Nguyen (Columbia, Missouri); Gary Stacey (Columbia, Missouri) |
| ABSTRACT | Provided herein are methods of obtaining, producing, identifying, and the like soybean plants having a genotype associated with a large-seed phenotype as well as plants, plant cells, and plant genomes comprising a genotype associated with a large-seed phenotype. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/530832 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8262 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154204 | TAKAHASHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yohei TAKAHASHI (San Diego, California); Felix HAUSER (San Diego, California); Julian I. SCHROEDER (La Jolla, California) |
| ABSTRACT | In alternative embodiments, provided are methods for: enhancing drought tolerance of crop plants and trees, enhancing salinity of tolerance of plants such as crop plants, enhancing early monitoring of drought, salinity and cold stress by plants such as crop plants and trees, enhancing stress resistance in plants such as crop plants and trees, by increasing the expression of or the activity of a Raf-like mitogen-activated protein (MAP) kinase kinase (MAPKK) kinase delta B3 family enzyme (or a Raf-like MAPKK kinase delta B3 family enzyme) (a M3K B3 family enzyme) in a plant or a tree cell or a plant or a tree. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 17/437586 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/12 (20130101) C12N 15/8273 (20130101) Original (OR) Class Enzymes C12Y 207/12002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154232 | Smolke et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNOR UNIVERSITY (STANFORD, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christina D. Smolke (Menlo Park, California); Catherine Thodey (Mountain View, California); Isis Trenchard (Redwood City, California); Stephanie Galanie (Palo Alto, California) |
| ABSTRACT | Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention. |
| FILED | Wednesday, October 27, 2021 |
| APPL NO | 17/512451 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0073 (20130101) C12N 9/1007 (20130101) C12N 15/52 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/18 (20130101) C12P 17/182 (20130101) Original (OR) Class Enzymes C12Y 121/03003 (20130101) C12Y 201/0114 (20130101) C12Y 201/01116 (20130101) C12Y 201/01128 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154310 | TAKEUCHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Iowa State University Research Foundation (Ames, Iowa); Colorado School of Mines (Golden, Colorado); The Government of the United States as Represented by the Secretary, Department of Energy, Ames Labo (Ames, Iowa) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); Iowa State University Research Foundation (Ames, Iowa); Colorado School of Mines (Golden, Colorado); The Government of the United States as Represented by the Secretary, Department of Energy, Ames Labo (Ames, Iowa) |
| INVENTOR(S) | Ichiro TAKEUCHI (Laurel, Maryland); Jun CUI (Ames, Iowa); Huilong HOU (Greenbelt, Maryland); Valery I. LEVITAS (Ames, Iowa); Ryan T. OTT (Ames, Iowa); Aaron P. STEBNER (Golden, Colorado) |
| ABSTRACT | The present disclosure provides stable elastocaloric cooling materials and methods for producing and using the same. Elastocaloric cooling materials of the present disclosure are capable of withstanding 106 cycles. In some embodiments, elastocaloric cooling materials of the present disclosure comprise a mixture of a transforming alloy and a non-transforming intermetallic phase at a ratio of from about 30-70% transforming alloy to about 70%-30% of non-transforming intermetallic phase. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526460 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/12 (20130101) Alloys C22C 1/02 (20130101) C22C 14/00 (20130101) Original (OR) Class C22C 2202/00 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 21/00 (20130101) F25B 2321/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154702 | Zavattieri et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Pablo ZAVATTIERI (West Lafayette, Indiana); Yunlan ZHANG (Foothill Ranch, California); Nilesh MANKAME (Ann Arbor, Michigan); David RESTREPO (San Antonio, Texas); Gordon JARROLD (Chicago, Illinois); Maria Mirian VELAY-LIZANCOS (West Lafayette, Indiana); PURDUE RESEARCH FOUNDATION (West Lafayette, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pablo Zavattieri (West Lafayette, Indiana); Yunlan Zhang (Foothill Ranch, California); Nilesh Mankame (Ann Arbor, Michigan); David Restrepo (San Antonio, Texas); Gordon Jarrold (Chicago, Illinois); Maria Milian Velay-Lizancos (West Lafayette, Indiana) |
| ABSTRACT | A phase transformational cellular material, including a plurality of bistable cells, each respective bistable cell operationally connected to at least one other respective bistable cell. Each bistable cell enjoys a first stable phase and a second stable phase. The first stable phase is a first geometric configuration and the second stable phase is a second geometric configuration different from the first geometric configuration. An energy transaction is required to shift each respective cell between stable phases. A mechanical energy transaction is required to shift from the first to the second phase, while a thermal energy transaction is required to shift from the second to the first phase. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 17/599154 |
| CURRENT CPC | Vehicle Tyres Tyre Inflation; Tyre Changing or Repairing; Repairing, or Connecting Valves To, Inflatable Elastic Bodies in General; Devices or Arrangements Related to Tyres B60C 7/14 (20130101) Buildings or Like Structures for Particular Purposes; Swimming or Splash Baths or Pools; Masts; Fencing; Tents or Canopies, in General E04H 9/0237 (20200501) Spring, Weight, Inertia or Like Motors; Mechanical-power Producing Devices or Mechanisms, Not Otherwise Provided for or Using Energy Sources Not Otherwise Provided for F03G 7/06115 (20210801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155010 | Strongrich et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Andrew Strongrich (West Lafayette, Indiana); Alina Alexeenko (West Lafayette, Indiana) |
| ABSTRACT | A system to monitor and control a lyophilization process using a wireless network is disclosed which includes one or more wireless pressure and gas temperature sensors adapted to provide pressure and gas temperature measurements of the ambient environment, a lyophilization chamber, wherein the one or more wireless pressure sensors are distributed in one or more lyophilization vial trays, a vacuum pump, adapted to change the pressure with the lyophilization chamber, a heat exchanger adapted to modify temperature within the lyophilization chamber, and a controller adapted to collect pressure and gas temperature data from the one or more wireless pressure and gas temperature sensors, calculate sublimation rate of a product to be lyophilized using the collected pressure and gas temperature data, and adjust one or both of pressure and temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/588929 |
| CURRENT CPC | Drying Solid Materials or Objects by Removing Liquid Therefrom F26B 5/06 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 25/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155160 | CAO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Yungi CAO (Pasadena, California); Nelson Sepulveda-Alancastro (Haslett, Michigan); Henry Dsouza (East Lansing, Michigan) |
| ABSTRACT | A sensor apparatus is provided. Multiple opposite and self-powered sensors are provided in another aspect of the present apparatus. A further aspect employs a sensor apparatus including a first pair of flexible piezoelectric sensors attached to opposite sides of an exterior surface of a workpiece and at least a second pair of flexible piezoelectric sensors attached to opposite sides of the exterior surface of the workpiece. Another aspect of the present apparatus uses pairs of thin film piezoelectric sensors which are configured to detect bending curvature of a workpiece in at least two dimensions by sending voltage output signals from both of the sensors of a first pair and/or both of the sensors of at least a second pair to a controller and/or electrical circuit. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/527478 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/16 (20130101) Original (OR) Class G01L 5/0052 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 3/066 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155444 | BRUECK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven R.J. BRUECK (Albuquerque, New Mexico); Payman ZARKESH-HA (Albuquerque, New Mexico); Alexander NEUMANN (Albuquerque, New Mexico) |
| ABSTRACT | An angular sensitive time-of-flight position sensor device is provided and includes an array of pixels each comprising: a planar waveguide structure; a collection area with a grating pattern at a specific periodicity to couple incident light into the planar waveguide structure; at least one detector placed outside of the collection area and in a plane different from that of the planar waveguide structure; an output coupler to direct the light from planar waveguide to the at least one detector; a mask to shield the at least one detector from direct illumination; a narrow band light source that illuminates a field-of-view; a first electronics configured to detect the time-of-flight of light retroreflected, scattered, or both incident onto the position sensor and configured to provide distance ranging information; and a second electronics configured to interpret and retain time-of-flight information and configured to communicate with external electronics for system applications. |
| FILED | Saturday, March 14, 2020 |
| APPL NO | 17/439291 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4814 (20130101) G01S 7/4816 (20130101) G01S 7/4865 (20130101) G01S 17/42 (20130101) Original (OR) Class G01S 17/931 (20200101) Optical Elements, Systems, or Apparatus G02B 6/0038 (20130101) G02B 6/42 (20130101) G02B 6/4206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155506 | Kolle et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Mathias Kolle (Hull, Massachusetts); Benjamin Miller (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure describes photonic materials that reversibly change color in response to the material being stretched or otherwise mechanically deformed. |
| FILED | Monday, September 13, 2021 |
| APPL NO | 17/473255 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 1/005 (20130101) G02B 5/287 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155621 | Miao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin C. Miao (Chicago, Illinois); Samuel J. Whiteley (Chicago, Illinois); David D. Awschalom (Chicago, Illinois) |
| ABSTRACT | The disclosure is directed to devices, systems, and methods for performing quantum state-mediated microwave-to-optical energy conversion. Such quantum state-mediated energy conversion may be achieved via coherent interactions between an optical excitation and microwave electric field mediated by various quantum states in a defect embedded in a crystalline lattice. Such energy conversion enables coherent electro-optical modulation of optical emission from the defect, microwave-optical transduction, optical detection of microwave, and optical frequency mixing in the optical emission from the defect. The optical emission from the defect maintains and carries quantum coherence in the defect. Such devices and methods may be applied in quantum information processing systems. |
| FILED | Wednesday, March 04, 2020 |
| APPL NO | 17/435987 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0327 (20130101) G02F 1/0344 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155730 | Ye et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Government of the United States of America as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Ye (Louisville, Colorado); Eric G. Oelker (Boulder, Colorado); William R. Milner (Boulder, Colorado); John M. Robinson (Henderson, Nevada); Colin J. Kennedy (Boulder, Colorado); Tobias Bothwell (Boulder, Colorado); Dhruv Kedar (Boulder, Colorado); Terry Brown (Lafayette, Colorado) |
| ABSTRACT | The frequency stability of an optical local oscillator is improved by locking a laser to a silicon Fabry-Perot cavity operating at a temperature near 124 K, where the coefficient of thermal expansion of silicon is near zero. The cavity is mounted inside a cryostat housed in a temperature-stabilized vacuum system that is surrounded by an isolating enclosure and supported by an active vibration platform. Laser light is steered with a superpolished mirror toward a superpolished focusing optic that couples the laser light into the cavity. Light reflected from the cavity is used to stabilize the laser via the Pound-Drever-Hall technique, while light transmitted through the cavity is used to stabilize the laser power. A resonant transimpedance amplifier allows the laser power to be reduced, which reduces heating of the cavity caused by residual absorption of the light. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127616 |
| CURRENT CPC | Time-interval Measuring G04F 5/14 (20130101) Original (OR) Class Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220156366 | Mishra et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Florida Research Foundation, Inc. (Gainesville, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Prabhat Kumar Mishra (Gainesville, Florida); Thelijjagoda Subodha Nadeeshan Charles (Matara, Sri Lanka); Vincent Bindschaedler (Gainesville, Florida) |
| ABSTRACT | The present disclosure describes digital watermark detection systems and methods. In one such system, a plurality of intellectual property cores are integrated on a system-on-chip, such that the intellectual property cores comprise a first intellectual property core and a second intellectual property core. The system further includes a first network interface connected to the first intellectual property core that can encode a first digital watermark into a packet stream designated for the second intellectual property core. The system further includes a second network interface connected to the second intellectual property core that can receive the packet stream and decode the packet stream to generate a second digital watermark. The second network interface is further configured to perform a validation test on the packet stream and deliver the packet stream to the second intellectual property core when the first digital watermark is determined to match the second digital watermark. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/525176 |
| CURRENT CPC | Electric Digital Data Processing G06F 7/582 (20130101) G06F 15/7807 (20130101) G06F 21/552 (20130101) Original (OR) Class G06F 2221/034 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 9/065 (20130101) H04L 49/109 (20130101) H04L 2209/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220156459 | HERR et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BLACKBOILER, INC. (Arlington, Virginia) |
| ASSIGNEE(S) | BLACKBOILER, INC. (Arlington, Virginia) |
| INVENTOR(S) | Jonathan HERR (Washington, District of Columbia); Daniel Edward SIMONSON (Arlington, Virginia); Daniel P. BRODERICK (Arlington, Virginia) |
| ABSTRACT | A method for suggesting revisions to a document-under-analysis from a seed database, the seed database including a plurality of original texts each respectively associated with one of a plurality of final texts, the method for suggesting revisions including selecting a statement-under-analysis (“SUA”), selecting a first original text of the plurality of original texts, determining a first edit-type classification of the first original text with respect to its associated final text, generating a first similarity score for the first original text based on the first edit-type classification, the first similarity score representing a degree of similarity between the SUA and the first original text, selecting a second original text of the plurality of original texts, determining a second edit-type classification of the second original text with respect to its associated final text, generating a second similarity score for the second original text based on the second edit-type classification, the second similarity score representing a degree of similarity between the SUA and the second original text, selecting a candidate original text from one of the first original text and the second original text, and creating an edited SUA (“ESUA”) by modifying a copy of the first SUA consistent with a first candidate final text associated with the first candidate original text. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/592588 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/35 (20190101) G06F 16/36 (20190101) G06F 16/383 (20190101) G06F 40/45 (20200101) G06F 40/131 (20200101) G06F 40/137 (20200101) G06F 40/166 (20200101) G06F 40/169 (20200101) G06F 40/194 (20200101) G06F 40/253 (20200101) Original (OR) Class G06F 40/268 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220156620 | McDermott, III et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Francis McDermott, III (Madison, Wisconsin); Alexander M. Opremcak (Madison, Wisconsin) |
| ABSTRACT | The disclosed technology is directed to systems and methods for deterministic reset of superconducting qubit and cavity modes with a microwave photon counter. The system comprises a multiplicity of qubit-microwave photon counter pairs coupled by a qubit-qubit coupling. Each of the qubit-microwave photon counter pairs comprise a qubit circuit, a microwave photon counter circuit, and a resonant cavity coupling the qubit circuit and the microwave photon counter circuit. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 16/952598 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 10/00 (20130101) Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/18 (20130101) H01L 39/223 (20130101) Pulse Technique H03K 19/195 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220157442 | Ning et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio); The Trustees of Indiana University (Bloomington, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xia Ning (Columbus, Ohio); Zhiyun Ren (Sunnyvale, California); Bo Peng (Columbus, Ohio); Titus K. Schleyer (Indianapolis, Indiana) |
| ABSTRACT | Disclosed embodiments include computer-implemented methods and systems that can efficiently generate highly relevant recommended search terms to clinicians. A hybrid collaborative filtering model recommends search terms for a specific patient to the clinician. The model draws on information from patients' clinical encounters and the searches that were performed during the clinical encounters. To generate recommendations, the model uses search terms which are (1) frequently co-occurring with the ICD codes recorded for the patient and (2) highly relevant to the most recent search terms. One variation of the model uses only the most recent ICD codes assigned to the patient. Another variation uses all ICD codes. Comprehensive experiments of embodiments of the methods and systems have demonstrate high levels of performance. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526591 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/24578 (20190101) G06F 17/16 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/20 (20180101) Original (OR) Class G16H 70/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220157455 | Mansfield et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Samuel Mansfield (Santa Cruz, California); Katia Obraczka (Santa Cruz, California) |
| ABSTRACT | Techniques monitoring and preventing a patient conditions include a sensing module, a storage module, an analysis module and a visualization module. The sensing module receives, from a sensor, samples that indicate measurements suitable for a condition of a patient and storing sample data in a local buffer. The storage module is configured to receive a sample data packet indicating sample type, patient identifier, device identifier, timestamp, and sample value, and to store them into a sample data structure. The analysis module is configured to determine a metric based on the sample value, and to store into that into a metric data structure metric type, patient identifier, device identifier, timestamp, and metric value. The visualization module is configured to present the sample or the metric on a display device configured to be viewed by a caregiver for the patient. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/455317 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/742 (20130101) A61B 5/7275 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 40/67 (20180101) Original (OR) Class G16H 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220158173 — MOF-SULFUR MATERIALS AND COMPOSITE MATERIALS, METHODS OF MAKING SAME, AND USES THEREOF
| US 20220158173 | Abruña et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CORNELL UNIVERSITY (Ithaca, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Héctor D. Abruña (Ithaca, New York); Na Zhang (Ithaca, New York) |
| ABSTRACT | MOFs including sulfur nanoparticles. The sulfur nanoparticles may be encapsulated in the MOFs. The MOFs may be made by methods where MOFs are formed in situ or are preformed prior to the incorporation of sulfur. The MOFs may be used to make composite materials. The composite materials may be used in cathodes. Cathodes may be used in devices. A device may be a battery. |
| FILED | Monday, March 09, 2020 |
| APPL NO | 17/435292 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/364 (20130101) Original (OR) Class H01M 4/625 (20130101) H01M 4/5815 (20130101) H01M 10/052 (20130101) H01M 10/054 (20130101) H01M 2004/028 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158497 | Babakhani et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Aydin Babakhani (Los Angeles, California); Hamed Rahmani (Princeton, New Jersey); Hidemasa Mitsui (Santa Clara, California) |
| ABSTRACT | Systems and methods for utilizing a small form-factor, wirelessly powered transceiver are disclosed. In one embodiment, a wireless powered transceiver includes a receive antenna configured to receive a receive signal, a transmit antenna configured to transmit a transmit signal, a power harvesting system including a rectifier circuit configured convert radio frequency energy from the receive signal into DC (direct current) voltage, and a power management unit (PMU) configured to set the operating mode and biasing condition of the receive and transmit circuitry blocks and provide DC voltage from the receive circuitry block to the transmit circuitry block to maintain a minimum voltage, a receiver circuitry block configured to provide energy from the receive signal to the power harvesting system, and a transmitter circuitry block including a data modulator circuit, the data modulator circuit configured to generate the transmit signal using DC voltage received from the power management unit. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/456328 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/001 (20200101) H02J 50/27 (20160201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158819 | SALMAN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Research Foundation for The State University of New York (Albany, New York) |
| ASSIGNEE(S) | The Research Foundation for The State University of New York (Albany, New York) |
| INVENTOR(S) | Emre SALMAN (Albany, New York); Milutin STANACEVIC (Albany, New York); Yasha KARIMI (Albany, New York); Tutu WAN (Albany, New York); Yuanfei HUANG (Albany, New York) |
| ABSTRACT | A processing unit and a method of operating a processing unit. In an embodiment, the processing unit comprises a SIMON block cipher for transforming plaintext data into encrypted data. A key expansion module generates and outputs one or more encryption keys; and the key expansion module includes a first series of adiabatic registers for holding key generation data values, and for using adiabatic switching to transmit the key generation data values through the first series of adiabatic registers. A round function module receives the plaintext data and the one or more encryption keys, encrypts the plaintext data to generate the encrypted data, and outputs the encrypted data; and the round function module includes a second series of adiabatic registers for holding encryption data, and for using adiabatic switching to transmit the encryption data through the second series of adiabatic registers. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/438662 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 9/0625 (20130101) Original (OR) Class H04L 9/0819 (20130101) H04L 2209/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220158880 — Communication Devices, Systems, Software and Methods employing Symbol Waveform Hopping
| US 20220158880 | PROTHERO |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Astrapi Corporation (Dallas, Texas) |
| ASSIGNEE(S) | Astrapi Corporation (Dallas, Texas) |
| INVENTOR(S) | Jerrold PROTHERO (Delray Beach, Florida) |
| ABSTRACT | Systems, devices, and methods of the present invention facilitate secure communication by altering the set of symbol waveforms that may be in use in particular symbol times defined herein as Symbol Waveform Hopping. SWH may be enabled by selecting two or more modulation formats that have sufficiently comparable communication performance (e.g., occupied bandwidth and signal power efficiency), but characterized by symbol waveform alphabet that include different symbol waveform, so that the overall transmission/communication performance of data stream in a signal transmission channel of the system is not significantly affected by switching between modulation formats. Some or all of the symbol waveforms in each alphabet may not be present in other alphabets. |
| FILED | Sunday, November 21, 2021 |
| APPL NO | 17/455915 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 1/0003 (20130101) H04L 1/0618 (20130101) H04L 5/0023 (20130101) H04L 27/0008 (20130101) Original (OR) Class H04L 27/34 (20130101) H04L 27/2602 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220159387 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qin Zhou (Fremont, California); Alexander K. Zettl (Kensington, California) |
| ABSTRACT | This disclosure provides a device that includes a graphene membrane and a first electrode proximate a first side of the graphene membrane, the first electrode being electrically conductive. The device further includes a frame comprising a first part and a second part, wherein the graphene membrane is suspended between the first part and the second part. The device is configured to have a frequency response across a frequency range at least from 20 Hz to 20 kHz or across the entire human audible frequency range. The device is a microphone or a loudspeaker. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590674 |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/02 (20130101) H04R 19/005 (20130101) Original (OR) Class H04R 23/002 (20130101) H04R 29/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220151516 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); North Carolina State University (Raleigh, North Carolina); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Wang (San Diego, California); Joshua Ray Windmiller (Del Mar, California); Roger Narayan (Raleigh, North Carolina); Phillip Miller (Greensboro, North Carolina); Ronen Polsky (Albuquerque, New Mexico); Thayne L. Edwards (Albuquerque, New Mexico) |
| ABSTRACT | Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/650056 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/157 (20130101) A61B 5/685 (20130101) A61B 5/1473 (20130101) Original (OR) Class A61B 5/4845 (20130101) A61B 5/6833 (20130101) A61B 5/7282 (20130101) A61B 5/14514 (20130101) A61B 5/14532 (20130101) A61B 5/14546 (20130101) A61B 5/14865 (20130101) A61B 5/150984 (20130101) A61B 10/0045 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/158 (20130101) A61M 5/1723 (20130101) A61M 2037/0023 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48785 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151528 | Yeo |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Woon-Hong Yeo (Atlanta, Georgia) |
| ABSTRACT | An exemplary embodiment of the present disclosure provides a method of determining stress levels in a user comprising: receiving galvanic skin response (GSR) measurements by a wearable sensor on the user over a period of time; receiving temperature measurements by the wearable sensor on the user over the period of time; determining changes in the temperature over a predetermined threshold in the temperature measurements over the period of time; calibrating the GSR measurements based on the determined changes in temperature over the predetermined threshold; calculating a stress level of the user based on the calibrated GSR measurements; and generating an output indicative of the calculated stress level. |
| FILED | Friday, January 28, 2022 |
| APPL NO | 17/587353 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/01 (20130101) A61B 5/0004 (20130101) A61B 5/165 (20130101) Original (OR) Class A61B 5/0533 (20130101) A61B 5/742 (20130101) A61B 5/6898 (20130101) A61B 5/7278 (20130101) A61B 2560/0223 (20130101) A61B 2560/0431 (20130101) A61B 2562/164 (20130101) A61B 2562/0209 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151530 | COSTELLA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | LUNA INNOVATIONS INCORPORATED (Roanoke, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Lauren Anne COSTELLA (Roanoke, Virginia); Christopher K. TISON (Roanoke, Virginia); Melissa SKOFF (Roanoke, Virginia); David REMER (Roanoke, Virginia); Kelsey BRODERICK (Roanoke, Virginia) |
| ABSTRACT | The novel flexible electrodes disclosed herein utilize the low bending stiffness of electrospun nanofiber mats to achieve the material properties required for surgical implantation and sustained bidirectional communication with peripheral nerves without compromising electronic functionality. According to certain embodiments disclosed herein, implantable neural electrode probes are provided which comprise a polymeric substrate having proximal and distal ends, an electrode interface at the proximal end of the substrate; at least one neural contact at the distal end of the substrate; and electrically conductive traces formed on the fibrous substrate providing electrical communication between the at least one neural contact and the electrode interface, wherein the substrate comprises a nonwoven mass of polymeric nanofibers. |
| FILED | Friday, March 06, 2020 |
| APPL NO | 17/435850 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/263 (20210101) Original (OR) Class A61B 2562/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151569 | Reifman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Government of the United States as represented by the Secretary of the Army (Fort Detrick, Maryland) |
| ASSIGNEE(S) | The Government of the United States as represented by the Secretary of the Army (Fort Detrick, Maryland) |
| INVENTOR(S) | Jaques Reifman (New Market, Maryland); Sidhartha Chaudhury (Baltimore, Maryland); Chenggang Yu (Boyds, Maryland); Samantha L. Hornby (Frederick, Maryland) |
| ABSTRACT | A method and a system analyze an individual's physiological data to identify aberrant vital-signs patterns and estimate an infection probability. The identification includes determining a score based on the current vital-sign measurements, and the mean and standard deviation of baseline vital-signs values. In one embodiment, the mean and the standard deviation are selected based on the corresponding baseline time window and activity bin of the current vital-sign measurement. The score is identified as normal when between two thresholds and aberrant outside of those two thresholds. Estimation of infection probability pt, at monitoring time t, is a recursive estimate of the infection probability of infection pt: |
| FILED | Saturday, November 13, 2021 |
| APPL NO | 17/525887 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0205 (20130101) A61B 5/681 (20130101) A61B 5/742 (20130101) A61B 5/746 (20130101) A61B 5/1118 (20130101) A61B 5/02438 (20130101) A61B 5/7275 (20130101) Original (OR) Class A61B 2562/0219 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151658 | McDonnall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ripple, LLC (Salt Lake City, Utah) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Allen McDonnall (Salt Lake City, Utah); Nathaniel Anthony Srok (Salt Lake City, Utah); Christopher Farand Smith (North Salt Lake, Utah) |
| ABSTRACT | Disclosed herein are systems and methods for insertion tools for implanting electrode leads. In one embodiment, an insertion tool comprises a shaft having an outer cannula and an inner cannula. An actuator may be configured to transition the insertion tool between at least three configurations. In a first configuration, the inner cannula and the outer cannula are configured to receive the lead in the shaft. In a second configuration, the inner cannula and the outer cannula are configured to secure the lead in the shaft. In a third configuration, the inner cannula and the outer cannula are configured to cause the lead to separate from the insertion tool and implant in adjacent tissue. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/591843 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 17/3421 (20130101) A61B 17/3468 (20130101) Original (OR) Class A61B 2017/00438 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/05 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151928 | Henrich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northwestern University (Evanston, Illinois) |
| ASSIGNEE(S) | Northwestern University (Evanston, Illinois) |
| INVENTOR(S) | Stephen E. Henrich (Chicago, Illinois); C. Shad Thaxton (Chicago, Illinois); Sonbinh T. Nguyen (Evanston, Illinois); Bong Jin Hong (Evanston, Illinois) |
| ABSTRACT | Disclosed herein are spherical high-density lipoprotein-like nanoparticles (HDL-NP) having a soft material core (e.g., a lipid-conjugated inorganic core). Also disclosed herein are methods for synthesizing the spherical HDL-NPs. Also disclosed herein are methods for treating disorders such as cardiovascular disease, cancer, inflammatory disorders or reducing NF-kB activity with the spherical HDL-NPs. |
| FILED | Friday, January 24, 2020 |
| APPL NO | 17/425401 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1275 (20130101) Original (OR) Class A61K 31/713 (20130101) A61K 47/54 (20170801) A61K 47/544 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151948 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Liangfang Zhang (San Diego, California); Che-Ming Jack Hu (Novato, California); Ronnie H. Fang (San Diego, California); Brian T. Luk (San Diego, California); Kuei-Chun Wang (San Diego, California); Shu Chien (La Jolla, California) |
| ABSTRACT | The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590684 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5153 (20130101) A61K 9/5169 (20130101) A61K 9/5176 (20130101) Original (OR) Class A61K 31/337 (20130101) A61K 47/6901 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 7/04 (20180101) A61P 9/00 (20180101) A61P 35/00 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152128 | Moran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nancy A. Moran (Austin, Texas); Sean Leonard (Austin, Texas); Waldan Kwong (Vancouver, Canada); Jenkyn Elijah Powell (Austin, Texas) |
| ABSTRACT | Provided herein are defined bacterial co-cultures, and methods of generating the same. Further provided are methods of using the defined bacterial co-cultures as probiotics to prevent diseases or disorders in bees and bee colonies. |
| FILED | Wednesday, February 19, 2020 |
| APPL NO | 17/431813 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0053 (20130101) A61K 35/741 (20130101) A61K 35/745 (20130101) A61K 35/747 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/14 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152628 | ABRAHAMSSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Christoffer Karl ABRAHAMSSON (Cambridge, Massachusetts); Amit NAGARKAR (Boston, Massachusetts); Michael J. FINK (Cambridge, Massachusetts); Markus P. NEMITZ (Newton, Massachusetts); Daniel J. PRESTON (Houston, Texas); Shencheng GE (Boston, Massachusetts); Joseph S. BOZENKO, JR. (Dulles, Virginia); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christoffer Karl ABRAHAMSSON (Cambridge, Massachusetts); Amit NAGARKAR (Boston, Massachusetts); Michael J. FINK (Cambridge, Massachusetts); Markus P. NEMITZ (Newton, Massachusetts); Daniel J. PRESTON (Cambridge, Massachusetts); Shencheng GE (Boston, Massachusetts); Joseph BOZENKO (Dulles, Virginia); George M. WHITESIDES (Newton, Massachusetts) |
| ABSTRACT | A magnetic levitation system is described, including a first and second magnets having surfaces of their like-poles facing each other; and a container disposed between the first and second magnets' like poles and containing a solution including a paramagnetic complex in a non-aqueous solvent, where the paramagnetic complex includes a paramagnetic metal and at least one ligand that coordinates to the paramagnetic metal via electron donation. Methods of separating a mixture of solid compounds, and/or identifying, confirming, and/or predicting the composition of the mixture, are also described. |
| FILED | Monday, March 16, 2020 |
| APPL NO | 17/439281 |
| CURRENT CPC | Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/01 (20130101) B03C 1/32 (20130101) Original (OR) Class B03C 1/288 (20130101) B03C 1/0332 (20130101) B03C 1/0335 (20130101) B03C 1/0337 (20130101) B03C 2201/18 (20130101) B03C 2201/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 21/65 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153405 | Tan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuehan Tan (Atlanta, Georgia); Ari Glezer (Atlanta, Georgia) |
| ABSTRACT | An embodiment of the present disclosure provides an airfoil comprising a trailing edge, a first fluidic outlet, and a first fluid supply. The trailing edge can have a first surface and a second surface opposing the first surface. The first fluidic outlet can be positioned on one of the first or second surfaces. The first fluid supply can be configured to eject a fluid out of the first fluidic outlet to alter an aerodynamic load experienced by the airfoil. |
| FILED | Friday, December 17, 2021 |
| APPL NO | 17/554571 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 21/04 (20130101) Original (OR) Class B64C 2230/18 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153575 | Plochowietz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne Plochowietz (Palo Alto, California); Bradley Rupp (San Francisco, California); Jengping Lu (Fremont, California); Julie A. Bert (East Palo Alto, California); Lara S. Crawford (Los Altos, California); Sourobh Raychaudhuri (Mountain View, California); Eugene M. Chow (Palo Alto, California); Matthew Shreve (Mountain View, California); Sergey Butylkov (Oakland, California) |
| ABSTRACT | Disclosed are methods and systems of controlling the placement of micro-objects on the surface of a micro-assembler. Control patterns may be used to cause electrodes of the micro-assembler to generate dielectrophoretic (DEP) and electrophoretic (EP) forces which may be used to manipulate, move, position, or orient one or more micro-objects on the surface of the micro-assembler. The control patterns may be part of a library of control patterns. |
| FILED | Wednesday, February 02, 2022 |
| APPL NO | 17/591493 |
| CURRENT CPC | Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 99/002 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/67271 (20130101) H01L 21/67294 (20130101) H01L 24/95 (20130101) H01L 2224/95133 (20130101) H01L 2224/95145 (20130101) H01L 2924/1461 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49131 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153576 | Plochowietz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Palo Alto Research Center Incorporated (Palo Alto, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anne Plochowietz (Palo Alto, California); Bradley Rupp (San Francisco, California); Jengping Lu (Fremont, California); Julie A. Bert (East Palo Alto, California); Lara S. Crawford (Los Altos, California); Sourobh Raychaudhuri (Mountain View, California); Eugene M. Chow (Palo Alto, California); Matthew Shreve (Mountain View, California); Sergey Butylkov (Oakland, California) |
| ABSTRACT | Disclosed are methods and systems of controlling the placement of micro-objects on the surface of a micro-assembler. Control patterns may be used to cause electrodes of the micro-assembler to generate dielectrophoretic (DEP) and electrophoretic (EP) forces which may be used to manipulate, move, position, or orient one or more micro-objects on the surface of the micro-assembler. The control patterns may be part of a library of control patterns. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/665305 |
| CURRENT CPC | Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 99/002 (20130101) Original (OR) Class Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 21/67271 (20130101) H01L 21/67294 (20130101) H01L 24/95 (20130101) H01L 2224/95133 (20130101) H01L 2224/95145 (20130101) H01L 2924/1461 (20130101) Technical Subjects Covered by Former US Classification Y10T 29/49131 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153656 | Flanders et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Opus 12 Incorporated (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas H. Flanders (San Francisco, California); Kendra P. Kuhl (Oakland, California); Etosha R. Cave (Berkeley, California); Sichao Ma (Dublin, California); Ziyang Huo (Moraga, California); Carter S. Haines (Berkeley, California); Timothy A. Bekkedahl (Sunnyvale, California); Kathryn L. Corp (Berkeley, California); Ashley D. Mishra (Danville, California); Edward Izett (Berkeley, California); Luka Stevic (Berkeley, California) |
| ABSTRACT | A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/452395 |
| CURRENT CPC | Separation B01D 53/18 (20130101) B01D 53/229 (20130101) B01D 53/1475 (20130101) B01D 53/1493 (20130101) B01D 2252/30 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/34 (20130101) C01B 3/503 (20130101) C01B 2203/062 (20130101) C01B 2203/0216 (20130101) C01B 2203/0405 (20130101) Acyclic or Carbocyclic Compounds C07C 1/0485 (20130101) Original (OR) Class C07C 4/02 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) C25B 9/23 (20210101) C25B 15/081 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153716 | Chea et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rowan University (Glassboro, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Chea (Sicklerville, New Jersey); Joseph F. Stanzione, III (Wilmington, Delaware); Kirti M. Yenkie (Glassboro, New Jersey) |
| ABSTRACT | The present disclosure describes a system for the commercial scale extraction of isoflavones from soybean meal. The system includes an optional grinder, an extraction component, a solid-liquid separation component, an acid hydrolysis component, a neutralization component, and a purification component. Also provided are methods of commercial scale extraction of one or more isoflavones from soybean meal. The method includes extracting an isoflavone glucoside from soybean meal, hydrolyzing the isoflavone glucoside to obtain an isoflavone aglycone, neutralizing the isoflavone aglycone, and purifying the isoflavone aglycone. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528805 |
| CURRENT CPC | Heterocyclic Compounds C07D 311/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153896 | Godman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | Government of the United States as Represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| INVENTOR(S) | Nicholas P. Godman (Kettering, Ohio); Timothy J. White (Longmont, Colorado); Hilmar Koerner (Beavercreek, Ohio); Benjamin A. Kowalski (Dayton, Ohio); Anesia D. Auguste (Beavercreek, Ohio); Tyler C. Guin (Aiken, South Carolina) |
| ABSTRACT | Shape-programmable liquid crystal elastomers. The shape-programmable liquid crystal elastomers being synthesized by filling an alignment cell with liquid crystal monomers. The liquid crystal monomers align to a surface of the alignment cell and then are polymerized with a dithiol chain transfer agent. The alignment cell is configured to impose a director orientation on a portion of the shape-programmable liquid crystal elastomer. For some embodiments, liquid crystal elastomer laminates are prepared by arranging a plurality of liquid crystal elastomers such that a director orientation of each liquid crystal elastomer of the plurality is in registered alignment with an adjacent liquid crystal elastomer of the plurality. The arrangement is secured and the plurality of liquid crystal elastomers cured. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533226 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 222/20 (20130101) Original (OR) Class C08F 2800/20 (20130101) C08F 2810/20 (20130101) Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 5/121 (20130101) C08J 2335/02 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 135/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153902 | Pyun et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Arizona Board of Regents on Behalf of the University of Arizona, a body corporate (Tucson, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of the University of Arizona, a body corporate (Tucson, Arizona) |
| INVENTOR(S) | Dong-Chul "Jeffrey" Pyun (Tucson, Arizona); Robert A. Norwood (Tucson, Arizona); Nicholas George Pavlopoulos (Tucson, Arizona); Kyle Carothers (Tucson, Arizona); Lindsey Holmen (Tucson, Arizona); Tobias Kochenderfer (Tucson, Arizona); Nicholas Lyons (Tucson, Arizona) |
| ABSTRACT | The present invention provides a composition comprising a plurality of magnetic nanocomposite particles. The magnetic nanocomposite particle comprises a magnetic metallic nanoparticle and a plurality of organic polymer ligands attached to its surface. The composition can also include a host matrix, such as a polymer, in which the magnetic nanocomposite particles are interspersed therein. The compositions of the invention have the Verdet constant of at least 5000°/T-m. |
| FILED | Wednesday, March 04, 2020 |
| APPL NO | 17/435645 |
| CURRENT CPC | Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 292/00 (20130101) Original (OR) Class Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/09 (20130101) G02F 1/0036 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/11 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153956 | Tan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Government of the United States, as represented by the Secretary of the Air Force (Wright-Patterson AFB, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Loon-Seng Tan (Centerville, Ohio); Zhenning Yu (Beavercreek, Ohio); Kyoungweon Park (Beavercreek, Ohio); Richard A. Vaia (Beavercreek, Ohio) |
| ABSTRACT | The invention relates to nanohybrids that are gold nanorod J-aggregates having a broadened surface plasmonic resonance band, processes of making such gold nanorod J-aggregates and products comprising such gold nanorod J-aggregates. Such gold nanorod J-aggregates exhibit broad localized surface plasmonic reasonable range from 800 nm to 2000 nm. |
| FILED | Wednesday, November 18, 2020 |
| APPL NO | 16/951666 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/203 (20130101) C08J 2379/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/08 (20130101) Original (OR) Class C08K 2003/0831 (20130101) Compositions of Macromolecular Compounds C08L 79/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154235 | Mershin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Andreas Mershin (Cambridge, Massachusetts); Katarzyna Paulina Adamala (Minneapolis, Minnesota) |
| ABSTRACT | Synells are created by encapsulating components and iteratively optimizing each synell for a desired trait. Each synell is tested during each iteration. Failed synells are discarded. Additional synell components are added during each iteration, with iterative optimization being repeated until synells having the trait are created. A method for synell reproduction includes creating a synell having a desired trait, determining a recipe for the synell, digitizing the recipe, and transmitting the digitized recipe to another location. The recipe is reconstituted at the other location and the synell is reproduced using the recipe. On-demand biosynthesis of synells includes generating droplets containing different synell components within a microfluidic device, fusing them into combinations, and storing them until a request for a synell having a particular trait is received. Fused droplets having the component combination for the trait, or being combinable to produce it, are retrieved and encapsulated to form the requested synell. |
| FILED | Monday, December 04, 2017 |
| APPL NO | 15/831379 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154237 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Lexington, Massachusetts); David Irby Bryson, JR. (Dorchester, Massachusetts) |
| ABSTRACT | The disclosure provides amino acid sequence variants of orthogonal aminoacyl-tRNA synthetases (AARSs) having increased activity and selectivity compared to previous AARSs, and methods of producing the same. |
| FILED | Tuesday, July 03, 2018 |
| APPL NO | 16/628456 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154670 | Coffee et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shawn Coffee (Tucson, Arizona); Saifur Ahmed (Oro Valley, Arizona); Steven D. Jacob (Oro Valley, Arizona); Thomas K. Harward (Tucson, Arizona) |
| ABSTRACT | An ignition safety device (ISD) used in an ignition system of a missile is configured to selectively control the ignition of two or more pulses or stages of a rocket motor propulsion system, based on a flight profile mode selection of a flight velocity mode, in which the missile is configured to travel at an optimized flight velocity, or a flight distance mode, in which the missile is configured to travel an optimized flight distance. The ISD is configured to selectively ignite the pulses or stages substantially simultaneously upon selection of the flight velocity mode, or in a delayed sequential manner upon selection of the flight distance mode. The ISD is also configured to selectively inhibit the delayed sequential ignition of the pulses or stages in the event of incidental ground or water impact of the missile after ignition of the primary pulse or stage. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 16/952928 |
| CURRENT CPC | Jet-propulsion Plants F02K 9/94 (20130101) Original (OR) Class F02K 9/95 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155025 | Lewis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | KELVIN THERMAL TECHNOLOGIES, INC. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan John Lewis (Boulder, Colorado); Yung-Cheng Lee (Boulder, Colorado); Li-Anne Liew (Westminster, Colorado); Yunda Wang (Denver, Colorado) |
| ABSTRACT | Embodiments described herein relate to the concept and designs of a polymer-based thermal ground plane. In accordance with one embodiment, a polymer is utilized as the material to fabricate the thermal ground plane. Other embodiments include am optimized wicking structure design utilizing two arrays of micropillars, use of lithography-based microfabrication of the TGP using copper/polymer processing, micro-posts, throttled releasing holes embedded in the micro-posts, atomic layer deposition (ALD) hydrophilic coating, throttled fluid charging structure and sealing method, defect-free ALD hermetic coating, and compliant structural design. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592490 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 1/00 (20130101) Processes or Apparatus Specially Adapted for the Manufacture or Treatment of Microstructural Devices or Systems B81C 1/00476 (20130101) B81C 2201/013 (20130101) B81C 2201/0107 (20130101) Heat-exchange Apparatus, Not Provided for in Another Subclass, in Which the Heat-exchange Media Do Not Come into Direct Contact F28D 15/046 (20130101) Original (OR) Class Details of Heat-exchange and Heat-transfer Apparatus, of General Application F28F 21/06 (20130101) F28F 2245/02 (20130101) F28F 2245/04 (20130101) F28F 2255/08 (20130101) F28F 2260/00 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 7/20336 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155621 | Miao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The University of Chicago (Chicago, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kevin C. Miao (Chicago, Illinois); Samuel J. Whiteley (Chicago, Illinois); David D. Awschalom (Chicago, Illinois) |
| ABSTRACT | The disclosure is directed to devices, systems, and methods for performing quantum state-mediated microwave-to-optical energy conversion. Such quantum state-mediated energy conversion may be achieved via coherent interactions between an optical excitation and microwave electric field mediated by various quantum states in a defect embedded in a crystalline lattice. Such energy conversion enables coherent electro-optical modulation of optical emission from the defect, microwave-optical transduction, optical detection of microwave, and optical frequency mixing in the optical emission from the defect. The optical emission from the defect maintains and carries quantum coherence in the defect. Such devices and methods may be applied in quantum information processing systems. |
| FILED | Wednesday, March 04, 2020 |
| APPL NO | 17/435987 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/0327 (20130101) G02F 1/0344 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155730 | Ye et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Government of the United States of America as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Ye (Louisville, Colorado); Eric G. Oelker (Boulder, Colorado); William R. Milner (Boulder, Colorado); John M. Robinson (Henderson, Nevada); Colin J. Kennedy (Boulder, Colorado); Tobias Bothwell (Boulder, Colorado); Dhruv Kedar (Boulder, Colorado); Terry Brown (Lafayette, Colorado) |
| ABSTRACT | The frequency stability of an optical local oscillator is improved by locking a laser to a silicon Fabry-Perot cavity operating at a temperature near 124 K, where the coefficient of thermal expansion of silicon is near zero. The cavity is mounted inside a cryostat housed in a temperature-stabilized vacuum system that is surrounded by an isolating enclosure and supported by an active vibration platform. Laser light is steered with a superpolished mirror toward a superpolished focusing optic that couples the laser light into the cavity. Light reflected from the cavity is used to stabilize the laser via the Pound-Drever-Hall technique, while light transmitted through the cavity is used to stabilize the laser power. A resonant transimpedance amplifier allows the laser power to be reduced, which reduces heating of the cavity caused by residual absorption of the light. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127616 |
| CURRENT CPC | Time-interval Measuring G04F 5/14 (20130101) Original (OR) Class Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220156301 | BOTMAN et al. |
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| FUNDED BY |
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| APPLICANT(S) | Arm Limited (Cambridge, United Kingdom) |
| ASSIGNEE(S) | |
| INVENTOR(S) | François Christopher Jacques BOTMAN (Cambridge, United Kingdom); Thomas Christopher GROCUTT (Cambridge, United Kingdom); Bradley John SMITH (Haverhill, United Kingdom) |
| ABSTRACT | Data processing apparatuses, methods and computer programs are disclosed. A range definition register is arranged to store a range specifier and filtering operations are performed with respect to a specified transaction by reference to the range definition register. The range definition register stores the range specifier in a format comprising a significand and an exponent, wherein a range of data identifiers is at least partially defined by the range specifier. When the specified transaction is with respect to a data identifier within the range of data identifiers, the filtering operations performed are dependent on attribute data associated with the range of data identifiers. |
| FILED | Monday, November 16, 2020 |
| APPL NO | 17/098815 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/335 (20190101) G06F 16/355 (20190101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220156319 | Abeloe et al. |
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| FUNDED BY |
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| APPLICANT(S) | Centauri, LLC (Chantilly, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth A. Abeloe (Carlsbad, California); Dennis Hsu (San Diego, California) |
| ABSTRACT | Systems and methods for full motion video search are provided. In one aspect, a method includes receiving one or more search terms. The search terms include one or more of a characterization of the amount of man-made features in a video image and a characterization of the amount of natural features in the video image. The method further includes searching a full motion video database based on the one or more search terms. |
| FILED | Thursday, January 06, 2022 |
| APPL NO | 17/647279 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/113 (20190101) G06F 16/783 (20190101) G06F 16/7837 (20190101) G06F 16/7847 (20190101) G06F 16/7867 (20190101) Original (OR) Class Image or Video Recognition or Understanding G06V 20/41 (20220101) G06V 20/176 (20220101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220156624 | SALIM et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ColdQuanta, Inc. (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Evan SALIM (Lafayette, Colorado); Dina GENKINA (Hyattsville, Maryland); Flavio CRUZ (Superior, Iceland); Judith OLSON (Northglenn, Colorado); Andrew KORTYNA (Boulder, Colorado) |
| ABSTRACT | An atomic clock employs hybrid long/short quantum clock frequency regulation wherein each of a series of regulation cycles includes a relatively long (four Ramsey-cycle) combination error signal (CES) cycle and plural relatively short (two Ramsey-cycle) single error signal (SES) cycles. The CES cycles provide for better long-term stability than can be provided using only SES cycles. However, including the SES cycles between CES cycles improves short term stability with negligible diminishment of long-term stability. |
| FILED | Friday, April 02, 2021 |
| APPL NO | 17/221047 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) Transmission H04B 10/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220156903 | McCall et al. |
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| FUNDED BY |
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| APPLICANT(S) | SPECTRAL MD, INC. (Dallas, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Brian McCall (Dallas, Texas); Wensheng Fan (Plano, Texas); Jason Dwight (Dallas, Texas); Zhicun Gao (Plano, Texas); Jeffrey E. Thatcher (Irving, Texas); John Michael DiMaio (Dallas, Texas) |
| ABSTRACT | Generally described, one or more aspects of the present application correspond to systems and techniques for spectral imaging using a multi-aperture system with curved multi-bandpass filters positioned over each aperture. The present disclosure further relates to techniques for implementing spectral unmixing and image registration to generate a spectral datacube using image information received from such imaging systems. Aspects of the present disclosure relate to using such a datacube to analyze the imaged object, for example to analyze tissue in a clinical setting, perform biometric recognition, or perform materials analysis. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/455856 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 7/0012 (20130101) G06T 7/33 (20170101) G06T 7/55 (20170101) G06T 7/62 (20170101) G06T 2207/10036 (20130101) G06T 2207/10144 (20130101) G06T 2207/20221 (20130101) Pictorial Communication, e.g Television H04N 5/265 (20130101) H04N 5/2254 (20130101) H04N 5/2256 (20130101) H04N 5/2356 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220156935 | Tiwari et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Case Western Reserve University (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pallavi Tiwari (Wexford, Pennsylvania); Anant Madabhushi (Shaker Heights, Ohio); Marwa Ismail (Louisville, Kentucky); Niha Beig (New Brunswick, New Jersey); Prateek Prasanna (Norfolk, Virginia) |
| ABSTRACT | Embodiments discussed herein facilitate determination of tumor mutation status based on context and spatial information. One example embodiment can access a MRI scan of a tumor comprising voxels; extract radiomic feature(s) from the voxels; generate a spatial feature descriptor indicating probabilities the tumor has a first mutation status and a second mutation status, based on the MRI scan, a first population atlas for the first mutation status, and a second population atlas for the second mutation status; provide the radiomic feature(s) and the spatial feature descriptor to a machine learning model; and receive, via the machine learning model, a map indicating, for each voxel of the voxels, a probability of the first mutation status for that voxel and a probability of the second mutation status for that voxel, wherein the map is based at least on the one or more radiomic features and the spatial feature descriptor. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 16/952615 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 7/0014 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220157995 | DAS et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE PENN STATE RESEARCH FOUNDATION (University Park, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saptarshi DAS (State College, Pennsylvania); Sarbashis DAS (State College, Pennsylvania); Akhil DODDA (State College, Pennsylvania) |
| ABSTRACT | Embodiments relate to a computing device that may be configured as a biomimetic audiomorphic device. The device can include a field effect transistor (FET) having a split-gate architecture with different spacing between the split-gates. Embodiments of the device can include multiple split-gates. Some embodiments include the integration of delay elements and tunable resistor-capacitance (RC) circuits for imitating the interaural time delay neurons. Some embodiments include global back-gating structural features to provide neuroplasticity aspects so as to provide adaptation related changes. |
| FILED | Tuesday, July 28, 2020 |
| APPL NO | 17/595741 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/1251 (20130101) H01L 29/24 (20130101) H01L 29/42384 (20130101) H01L 29/78648 (20130101) Original (OR) Class H01L 29/78696 (20130101) H01L 51/0554 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158231 | Smirnova et al. |
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| FUNDED BY |
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| APPLICANT(S) | South Dakota Board of Regents (Pierre, South Dakota) |
| ASSIGNEE(S) | South Dakota Board of Regents (Pierre, South Dakota) |
| INVENTOR(S) | Alevtina Smirnova (Rapid City, South Dakota); Matthew Dondelinger (Rapid City, South Dakota); Joel Swanson (Rapid City, South Dakota) |
| ABSTRACT | The present disclosure relates to a manufacturing process of the solid-state glass-ceramic electrolytes, known in the art as antiperovskites. Specifically, the disclosure is focused on manufacturing of the solid-state electrolyte from the corresponding precursors directly on the active electrode surface of an electrochemical device, specifically anode or cathode of the lithium-ion or lithium metal batteries. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592314 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/661 (20130101) H01M 10/052 (20130101) H01M 10/0562 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158338 | Merulla |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States, as represented by the Secretary of the Army (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Emanuel Merulla (Bel Air, Maryland) |
| ABSTRACT | Various embodiments are described that relate to an antenna. In one embodiment, the antenna can be a low profile, multi-band (e.g., dual band), emulated GPS constellation antenna. In one embodiment, the antenna can form a cube with two open sides and four circuit board sides. The four circuit boards can include a first hardware portion that allows functioning in a higher frequency band and a second hardware portion that allows functioning in a lower frequency band. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/588368 |
| CURRENT CPC | Antennas, i.e Radio Aerials H01Q 1/38 (20130101) Original (OR) Class H01Q 5/335 (20150115) H01Q 9/27 (20130101) H01Q 21/205 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158405 | Wittek et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| ASSIGNEE(S) | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (Orlando, Florida) |
| INVENTOR(S) | Steffen Wittek (Orlando, Florida); Juan Carlos Alvarado Zacarias (Orlando, Florida); Daniel Cruz Delgado (Orlando, Florida); Jose Enrique Antonio Lopez (Orlando, Florida); Rodrigo Amezcua Correa (Orlando, Florida); Matthew Cooper (Orlando, Florida) |
| ABSTRACT | Apparatus and methods for mitigating transverse mode instabilities (TMI) in high power fiber amplifiers that does not depend on active feedback loops. The apparatus and method involve the modulation of the amplitude and/or phase of selected spatial mode components of an input signal beam to increase the TMI threshold of the amplifier. Once the desired modal adjustments are made, the beam is input to a mode multiplexer whereupon an optimized output beam can be input to the active fiber of the amplifier system. By increasing the TMI threshold of the amplifier, the amplifier can be operated at higher power before TMI sets in. A control stage of the fiber amplifier system includes (a) a (seed) beam splitting section; (b) an amplitude and phase control component; and (c) a mode multiplexer that maps multiple individual signal beams to different fiber modes. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/455726 |
| CURRENT CPC | Devices Using the Process of Light Amplification by Stimulated Emission of Radiation [LASER] to Amplify or Generate Light; Devices Using Stimulated Emission of Electromagnetic Radiation in Wave Ranges Other Than Optical H01S 3/06716 (20130101) H01S 3/06733 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158602 | CHO et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Han Na CHO (Dublin, Ohio); Jun YU (Columbus, Ohio) |
| ABSTRACT | Frequency stabilization is provided in a microelectromechanical systems (MEMS) oscillator via tunable internal resonance (IR). A device comprises a MEMS resonator comprising a stepped-beam structure that is a thin-layer structure. The resonator may be configured to implement IR. The stepped-beam structure may be configured to provide flexibility to adjust modal frequencies into a n:m ratio, wherein n and m are integers. The thin-layer structure provides frequency tunability by controlling the mid-plane stretching effect with an applied DC bias. The thin-layer structure compensates for a frequency mismatch from a n:m ratio due to a fabrication error. The MEMS resonator may be an oscillator. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/439149 |
| CURRENT CPC | Impedance Networks, e.g Resonant Circuits; Resonators H03H 3/0077 (20130101) Original (OR) Class H03H 9/02409 (20130101) H03H 9/2463 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220159387 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qin Zhou (Fremont, California); Alexander K. Zettl (Kensington, California) |
| ABSTRACT | This disclosure provides a device that includes a graphene membrane and a first electrode proximate a first side of the graphene membrane, the first electrode being electrically conductive. The device further includes a frame comprising a first part and a second part, wherein the graphene membrane is suspended between the first part and the second part. The device is configured to have a frequency response across a frequency range at least from 20 Hz to 20 kHz or across the entire human audible frequency range. The device is a microphone or a loudspeaker. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590674 |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/02 (20130101) H04R 19/005 (20130101) Original (OR) Class H04R 23/002 (20130101) H04R 29/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220151516 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); North Carolina State University (Raleigh, North Carolina); National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Wang (San Diego, California); Joshua Ray Windmiller (Del Mar, California); Roger Narayan (Raleigh, North Carolina); Phillip Miller (Greensboro, North Carolina); Ronen Polsky (Albuquerque, New Mexico); Thayne L. Edwards (Albuquerque, New Mexico) |
| ABSTRACT | Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/650056 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/157 (20130101) A61B 5/685 (20130101) A61B 5/1473 (20130101) Original (OR) Class A61B 5/4845 (20130101) A61B 5/6833 (20130101) A61B 5/7282 (20130101) A61B 5/14514 (20130101) A61B 5/14532 (20130101) A61B 5/14546 (20130101) A61B 5/14865 (20130101) A61B 5/150984 (20130101) A61B 10/0045 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/158 (20130101) A61M 5/1723 (20130101) A61M 2037/0023 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/48785 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151924 | Brinker et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | C. Jeffrey Brinker (Albuquerque, New Mexico); Jimin Guo (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | C. Jeffrey Brinker (Albuquerque, New Mexico); Jimin Guo (Albuquerque, New Mexico); Wei Zhu (Albuquerque, New Mexico) |
| ABSTRACT | A method to prepare a population of metal-organic polyhedra (MOP) supported micelle nanoparticles (NPs), and a composition comprising MOP supported micelle NPs, are provided. |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 17/434363 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1075 (20130101) Original (OR) Class A61K 31/704 (20130101) A61K 33/242 (20190101) A61K 47/10 (20130101) A61K 47/24 (20130101) A61K 47/6849 (20170801) A61K 47/6907 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152003 | Abergel et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca J. Abergel (Kensington, California); Taylor A. Choi (South San Francisco, California); Kenneth N. Raymond (Berkeley, California); David K. Shuh (Oakland, California) |
| ABSTRACT | Provided herein are pharmaceutical formulations comprising a 1,2-HOPO chelating agent and/or a 3,2-HOPO chelating agent. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/665135 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/0056 (20130101) A61K 9/0095 (20130101) A61K 9/1611 (20130101) A61K 9/1623 (20130101) A61K 9/1652 (20130101) A61K 9/2009 (20130101) A61K 9/2018 (20130101) A61K 9/2054 (20130101) A61K 31/444 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152433 | Winrow et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico); Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward G. Winrow (Albuquerque, New Mexico); Katherine Anne Barrick (Bosque Farms, New Mexico); Todd Andrew Barrick (Bosque Farms, New Mexico); Victor H. Chavez (Edgewood, New Mexico); Lorenzo Jiron (Sandia Park, New Mexico); Thomas John Rogers (Albuquerque, New Mexico); Eric A. Shaner (Rio Rancho, New Mexico); Zachary Medaris Wilson (Albuquerque, New Mexico); Devyani Lal (Scottsdale, Arizona); John M. Angeli (Rochester, Minnesota); Mark B. Wehde (Saint Paul, Minnesota) |
| ABSTRACT | A reusable, protective face mask has two detachable filter trays that attach on each side of the mask, a soft elastomeric face seal, and straps to go around the user's head. Exhalations and inhalations can pass through the same filter material. The filter trays can accept arbitrary filter media. A forward-facing port can be used to increase speech intelligibility by transmitting sound through a diaphragm without a prohibitive amount of distortion. Manufacture of the mask is facilitated because the mask body and the other mask components can be produced by injection molding. Decontamination and sterilization are facilitated because the mask can be fully disassembled. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526688 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/1107 (20130101) A41D 13/1161 (20130101) Devices, Apparatus or Methods for Life-saving A62B 23/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152585 | Khivantsev et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| ASSIGNEE(S) | BATTELLE MEMORIAL INSTITUTE (Richland, Washington) |
| INVENTOR(S) | Konstantin Khivantsev (Richland, Washington); Libor Kovarik (West Richland, Washington); Janos Szanyi (Richland, Washington); Yong Wang (Richland, Washington); Ja-Hun Kwak (Richland, Washington); Nicholas R. Jaegers (Richmond, California) |
| ABSTRACT | A material and a method of making hydrothermally stable (catalytic) materials on the basis of theta-alumina support that is thermally and hydrothermally stable up to 1,150 C with metal, mixed metal-, metal-oxide nanoparticles dispersed upon it. Such materials did not lose significant amounts of their catalytic activity at temperature ranges for industrially relevant applications (including hydrocarbon oxidation, nitric oxide reduction, carbon monoxide oxidation) even after hydrothermal aging up to 1,150° C. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528849 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 21/04 (20130101) Original (OR) Class B01J 23/44 (20130101) B01J 23/464 (20130101) B01J 35/06 (20130101) B01J 35/1014 (20130101) B01J 37/088 (20130101) B01J 37/0207 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152628 | ABRAHAMSSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Christoffer Karl ABRAHAMSSON (Cambridge, Massachusetts); Amit NAGARKAR (Boston, Massachusetts); Michael J. FINK (Cambridge, Massachusetts); Markus P. NEMITZ (Newton, Massachusetts); Daniel J. PRESTON (Houston, Texas); Shencheng GE (Boston, Massachusetts); Joseph S. BOZENKO, JR. (Dulles, Virginia); President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christoffer Karl ABRAHAMSSON (Cambridge, Massachusetts); Amit NAGARKAR (Boston, Massachusetts); Michael J. FINK (Cambridge, Massachusetts); Markus P. NEMITZ (Newton, Massachusetts); Daniel J. PRESTON (Cambridge, Massachusetts); Shencheng GE (Boston, Massachusetts); Joseph BOZENKO (Dulles, Virginia); George M. WHITESIDES (Newton, Massachusetts) |
| ABSTRACT | A magnetic levitation system is described, including a first and second magnets having surfaces of their like-poles facing each other; and a container disposed between the first and second magnets' like poles and containing a solution including a paramagnetic complex in a non-aqueous solvent, where the paramagnetic complex includes a paramagnetic metal and at least one ligand that coordinates to the paramagnetic metal via electron donation. Methods of separating a mixture of solid compounds, and/or identifying, confirming, and/or predicting the composition of the mixture, are also described. |
| FILED | Monday, March 16, 2020 |
| APPL NO | 17/439281 |
| CURRENT CPC | Magnetic or Electrostatic Separation of Solid Materials From Solid Materials or Fluids; Separation by High-voltage Electric Fields B03C 1/01 (20130101) B03C 1/32 (20130101) Original (OR) Class B03C 1/288 (20130101) B03C 1/0332 (20130101) B03C 1/0335 (20130101) B03C 1/0337 (20130101) B03C 2201/18 (20130101) B03C 2201/26 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/28 (20130101) G01N 21/65 (20130101) Computer Systems Based on Specific Computational Models G06N 3/08 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152677 | Whalen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Scott A. Whalen (West Richland, Washington); Vineet V. Joshi (Richland, Washington); MD. Reza-E-Rabby (Richland, Washington); Jens T. Darsell (West Richland, Washington); Mageshwari Komarasamy (Richland, Washington); Curt A. Lavender (Richland, Washington); Glenn J. Grant (Benton City, Washington); Aashish Rohatgi (Richland, Washington); William E. Frazier, III (Richland, Washington) |
| ABSTRACT | Devices and methods for performing shear-assisted extrusion processes for forming extrusions of a desired composition from a feedstock material are provided. The processes can use a device having a scroll face having an inner diameter portion bounded by an outer diameter portion, and a member extending from the inner diameter portion beyond a surface of the outer diameter portion. Extrusion feedstocks and extrusion processes are provided for forming extrusions of a desired composition from a feedstock. The processes can include providing a feedstock having at least two different materials and engaging the materials with one another within a feedstock container. Methods for preparing metal sheets are provided that can include preparing a metal tube via shear assisted processing and extrusion; opening the metal tube to form a sheet having a first thickness; and rolling the sheet to a second thickness that is less than the first thickness. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/665433 |
| CURRENT CPC | Manufacture of Metal Sheets, Wire, Rods, Tubes or Profiles, Otherwise Than by Rolling; Auxiliary Operations Used in Connection With Metal-working Without Essentially Removing Material B21C 23/002 (20130101) Original (OR) Class B21C 23/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153656 | Flanders et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Opus 12 Incorporated (Berkeley, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas H. Flanders (San Francisco, California); Kendra P. Kuhl (Oakland, California); Etosha R. Cave (Berkeley, California); Sichao Ma (Dublin, California); Ziyang Huo (Moraga, California); Carter S. Haines (Berkeley, California); Timothy A. Bekkedahl (Sunnyvale, California); Kathryn L. Corp (Berkeley, California); Ashley D. Mishra (Danville, California); Edward Izett (Berkeley, California); Luka Stevic (Berkeley, California) |
| ABSTRACT | A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition. |
| FILED | Tuesday, October 26, 2021 |
| APPL NO | 17/452395 |
| CURRENT CPC | Separation B01D 53/18 (20130101) B01D 53/229 (20130101) B01D 53/1475 (20130101) B01D 53/1493 (20130101) B01D 2252/30 (20130101) Non-metallic Elements; Compounds Thereof; C01B 3/34 (20130101) C01B 3/503 (20130101) C01B 2203/062 (20130101) C01B 2203/0216 (20130101) C01B 2203/0405 (20130101) Acyclic or Carbocyclic Compounds C07C 1/0485 (20130101) Original (OR) Class C07C 4/02 (20130101) Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 1/23 (20210101) C25B 9/23 (20210101) C25B 15/081 (20210101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153888 | Wilson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas S. Wilson (San Leandro, California); Alexandra Melody Golobic (Pleasanton, California); Jeremy M. Lenhardt (Tracy, California); Spencer Schmidt (Oakland, California) |
| ABSTRACT | A polyolefin-based ink for additive manufacturing includes a polyolefin copolymer having a molecular weight no more than five times the entanglement molecular weight of the polyolefin copolymer, wherein the polyolefin copolymer comprises at least one type of functional group for crosslinking. A product of additive manufacturing with a polyolefin-based ink includes a three-dimensional structure including an extruded continuous filament arranged in a predefined pattern. The continuous filament includes a polyolefin matrix having a microstructure, where the microstructure is retained after curing. |
| FILED | Friday, November 13, 2020 |
| APPL NO | 17/098109 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/118 (20170801) B29C 64/209 (20170801) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) Macromolecular Compounds Obtained by Reactions Only Involving Carbon-to-carbon Unsaturated Bonds C08F 210/18 (20130101) Original (OR) Class C08F 2800/20 (20130101) Compositions of Macromolecular Compounds C08L 23/16 (20130101) C08L 2201/08 (20130101) C08L 2205/02 (20130101) C08L 2205/03 (20130101) C08L 2312/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154092 | Ohler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Amyris, Inc. (Emeryville, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nicholas Ohler (Emeryville, California); Karl Fisher (Emeryville, California); Jin Ki Hong (Emeryville, California) |
| ABSTRACT | Provided herein are olefinic feedstocks derived from conjugated hydrocarbon terpenes (e.g., C10-C50 terpenes), methods for making the same, and methods for their use. |
| FILED | Wednesday, November 03, 2021 |
| APPL NO | 17/518540 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 5/03 (20130101) C07C 5/05 (20130101) C07C 2521/04 (20130101) C07C 2523/44 (20130101) C07C 2523/75 (20130101) Fuels Not Otherwise Provided for; Natural Gas; Synthetic Natural Gas Obtained by Processes Not Covered by Subclasses C10G, C10K; Liquefied Petroleum Gas; Adding Materials to Fuels or Fires to Reduce Smoke or Undesirable Deposits or to Facilitate Soot Removal; Firelighters C10L 1/04 (20130101) Lubricating Compositions; Use of Chemical Substances Either Alone or as Lubricating Ingredients in a Lubricating Composition C10M 105/02 (20130101) Original (OR) Class C10M 105/04 (20130101) C10M 107/14 (20130101) C10M 2203/003 (20130101) C10M 2203/022 (20130101) C10M 2203/024 (20130101) C10M 2203/0206 (20130101) C10M 2205/083 (20130101) Climate Change Mitigation Technologies in the Production or Processing of Goods Y02P 20/582 (20151101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154199 | Dixon et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF NORTH TEXAS (Denton, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Richard A. Dixon (Sulphur, Oklahoma); Fang Chen (Denton, Texas); Chunliu Zhuo (Denton, Texas) |
| ABSTRACT | The disclosure provides recombinant LAC polynucleotides encoding a laccase (LAC) polypeptide capable of polymerizing caffeyl alcohol, vectors and cells including the recombinant LAC polynucleotide. The disclosure also provides transgenic plants including cells having the recombinant LAC polynucleotide of the present disclosure and methods of increasing production of C-lignin in a plant. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528375 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/8218 (20130101) C12N 15/8255 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154237 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David R. Liu (Lexington, Massachusetts); David Irby Bryson, JR. (Dorchester, Massachusetts) |
| ABSTRACT | The disclosure provides amino acid sequence variants of orthogonal aminoacyl-tRNA synthetases (AARSs) having increased activity and selectivity compared to previous AARSs, and methods of producing the same. |
| FILED | Tuesday, July 03, 2018 |
| APPL NO | 16/628456 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/02 (20130101) Original (OR) Class Enzymes C12Y 601/01026 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154310 | TAKEUCHI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Iowa State University Research Foundation (Ames, Iowa); Colorado School of Mines (Golden, Colorado); The Government of the United States as Represented by the Secretary, Department of Energy, Ames Labo (Ames, Iowa) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); Iowa State University Research Foundation (Ames, Iowa); Colorado School of Mines (Golden, Colorado); The Government of the United States as Represented by the Secretary, Department of Energy, Ames Labo (Ames, Iowa) |
| INVENTOR(S) | Ichiro TAKEUCHI (Laurel, Maryland); Jun CUI (Ames, Iowa); Huilong HOU (Greenbelt, Maryland); Valery I. LEVITAS (Ames, Iowa); Ryan T. OTT (Ames, Iowa); Aaron P. STEBNER (Golden, Colorado) |
| ABSTRACT | The present disclosure provides stable elastocaloric cooling materials and methods for producing and using the same. Elastocaloric cooling materials of the present disclosure are capable of withstanding 106 cycles. In some embodiments, elastocaloric cooling materials of the present disclosure comprise a mixture of a transforming alloy and a non-transforming intermetallic phase at a ratio of from about 30-70% transforming alloy to about 70%-30% of non-transforming intermetallic phase. |
| FILED | Monday, November 15, 2021 |
| APPL NO | 17/526460 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/12 (20130101) Alloys C22C 1/02 (20130101) C22C 14/00 (20130101) Original (OR) Class C22C 2202/00 (20130101) Refrigeration Machines, Plants or Systems; Combined Heating and Refrigeration Systems; Heat-pump Systems F25B 21/00 (20130101) F25B 2321/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154348 | FOULIARD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Central Florida Research Foundation, Inc. (Orlando, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | QUENTIN FOULIARD (Winter Park, Florida); RANAJAY GHOSH (Oviedo, Florida); SEETHA RAGHAVAN (Oviedo, Florida) |
| ABSTRACT | A thermal barrier coated component, such as a turbine blade formed from a superalloy substrate, includes a thermal barrier coating applied onto the substrate. A metallic bond coat layer is on the substrate and includes rare-earth luminescent dopants. A ceramic top coat layer is on the bond coat layer. A temperature sensing thermally grown oxide (TGO) layer is formed at the interface of the bond coat layer and ceramic top coat layer. The temperature sensing TGO layer includes grown rare-earth luminescent ions migrated from the metallic bond coat layer in an amount sufficient to enable luminescence sensing of the TGO layer for real-time phosphor thermometry temperature measurements at the TGO layer. |
| FILED | Friday, February 04, 2022 |
| APPL NO | 17/649929 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/7783 (20130101) Coating Metallic Material; Coating Material With Metallic Material; Surface Treatment of Metallic Material by Diffusion into the Surface, by Chemical Conversion or Substitution; Coating by Vacuum Evaporation, by Sputtering, by Ion Implantation or by Chemical Vapour Deposition, in General C23C 28/321 (20130101) C23C 28/3455 (20130101) Original (OR) Class Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 11/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154766 | PANAS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); The Regents of the University of California (Oakland, California); Bright Silicon Technologies, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert Matthew PANAS (Dublin, California); Jonathan HOPKINS (Los Angeles, California); Robert MCHENRY (San Francisco, California) |
| ABSTRACT | The present disclosure relates to a cross-pivot flexure system. In one embodiment the system may incorporate a center post element having a first head at a first end thereof, and a second head at a second end thereof. The first head may be arranged along a first longitudinal axis and the second head may be arranged along a second longitudinal axis. The first head may be attached to an immovable ground element through at least one first cross-pivot element for enabling rotational movement about the first longitudinal axis, while the second head may be attached to a motion stage flexure via at least one second cross-pivot element. This construction permits rotational movement of the second head about the second rotational axis. The first and second longitudinal axes are further arranged so that they intersect one another. |
| FILED | Thursday, November 19, 2020 |
| APPL NO | 16/953039 |
| CURRENT CPC | Shafts; Flexible Shafts; Elements or Crankshaft Mechanisms; Rotary Bodies Other Than Gearing Elements; Bearings F16C 11/12 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155069 | PREVISIC et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Re Vision Consulting, LLC (Sacramento, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mirko PREVISIC (Sacramento, California); Ravi CHALLA (Sacramento, California); Anantha KARTHIKEYAN (Sacramento, California) |
| ABSTRACT | A method and system for prediction of wave properties include collecting time series data streams from one or more wave measurement devices and processing the data using a wave-prediction algorithm to identify the frequency components of the data and compute wave parameters. The wave-field is propagated in space and time to predict wave height, speed, and velocity at a target location. A sliding window approach is used to continuously update the prediction in real-time. |
| FILED | Monday, March 02, 2020 |
| APPL NO | 17/435684 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 13/002 (20130101) Original (OR) Class Systems for Controlling or Regulating Non-electric Variables G05D 1/0206 (20130101) Electric Digital Data Processing G06F 30/28 (20200101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155444 | BRUECK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNM RAINFOREST INNOVATIONS (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven R.J. BRUECK (Albuquerque, New Mexico); Payman ZARKESH-HA (Albuquerque, New Mexico); Alexander NEUMANN (Albuquerque, New Mexico) |
| ABSTRACT | An angular sensitive time-of-flight position sensor device is provided and includes an array of pixels each comprising: a planar waveguide structure; a collection area with a grating pattern at a specific periodicity to couple incident light into the planar waveguide structure; at least one detector placed outside of the collection area and in a plane different from that of the planar waveguide structure; an output coupler to direct the light from planar waveguide to the at least one detector; a mask to shield the at least one detector from direct illumination; a narrow band light source that illuminates a field-of-view; a first electronics configured to detect the time-of-flight of light retroreflected, scattered, or both incident onto the position sensor and configured to provide distance ranging information; and a second electronics configured to interpret and retain time-of-flight information and configured to communicate with external electronics for system applications. |
| FILED | Saturday, March 14, 2020 |
| APPL NO | 17/439291 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/4814 (20130101) G01S 7/4816 (20130101) G01S 7/4865 (20130101) G01S 17/42 (20130101) Original (OR) Class G01S 17/931 (20200101) Optical Elements, Systems, or Apparatus G02B 6/0038 (20130101) G02B 6/42 (20130101) G02B 6/4206 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155472 | GOETZ et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | KATHLEEN C. GOETZ (Knoxville, Tennessee); Mustafa S. Cetiner (Lexington, Massachusetts) |
| ABSTRACT | A detector for generating an electrical current that is proportional to a flux of neutrons includes a neutron sensitive emitter, a conductive collector, an insulator between the neutron-sensitive emitter and the collector, an electrical connection to the neutron sensitive emitter, and an electrical connection to the conductive collector. The neutron sensitive emitter includes an emitter material with no more than 2 stable isotopes, and which upon impact by a neutron having an energy of from 100 keV to 1000 keV will generate electrons in proportion to the flux of neutrons in less than 10 minutes, and any generated electrons not generated in less than 10 minutes will be generated in no less than 30 days. A method of detecting neutrons generated by a nuclear reactor is also disclosed. |
| FILED | Monday, October 25, 2021 |
| APPL NO | 17/510044 |
| CURRENT CPC | Measurement of Nuclear or X-radiation G01T 3/006 (20130101) Original (OR) Class Nuclear Reactors G21C 17/102 (20130101) G21C 17/108 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220157478 | Wang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yifeng Wang (Albuquerque, New Mexico); David Louie (Albuquerque, New Mexico); Rekha R. Rao (Albuquerque, New Mexico); Jeremy A. Templeton (Castro Valley, California) |
| ABSTRACT | Systems and methods for injecting a carbonate-based sacrificial material into a nuclear reactor containment for containment of molten corium in severe nuclear reactor accidents are disclosed. Molten corium can be quickly cooled and solidified by the endothermic decomposition of the sacrificial material. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/665719 |
| CURRENT CPC | Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 5/18 (20130101) Nuclear Reactors G21C 9/00 (20130101) G21C 9/016 (20130101) Original (OR) Class G21C 15/18 (20130101) G21C 19/48 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220157499 | Vaidya et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee); University of Tennessee Research Foundation (Knoxville, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Uday Kumar Vaidya (Birmingham, Alabama); Mariappan Parans Paranthaman (Knoxville, Tennessee); Vlastimil Kunc (Knoxville, Tennessee); Ahmed A. Hassen (Knoxville, Tennessee) |
| ABSTRACT | A method for producing a bonded magnet, comprising: (i) low-shear compounding of a thermoplastic polymer and magnetic particles to form an initial homogeneous mixture thereof; (ii) feeding the initial homogeneous mixture into a plasticator comprising a low-shear single screw rotating unidirectionally toward a die orifice and housed within a heated barrel to result in heating of the initial homogeneous mixture until the thermoplastic polymer melts and forms a further homogeneous mixture, wherein said further homogeneous mixture is transported within threads of the single screw towards the die orifice and exits the die orifice as a solid pellet; (iii) conveying the solid pellet into a mold and compression molding the pellet in the mold, to form the bonded magnet, wherein the bonded magnet possesses a magnetic particle loading of at least 80 vol % and exhibits one or more magnetic properties varying by less than 5% throughout the bonded magnet. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529588 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 1/0059 (20130101) B22F 3/02 (20130101) B22F 2301/355 (20130101) Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 1/057 (20130101) H01F 1/147 (20130101) Original (OR) Class H01F 41/0253 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158105 | Hammond et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SolarWindow Technologies, Inc. (Scottsdale, Arizona); Alliance for Sustainable Energy, LLC (Golden, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott R. Hammond (Wheat Ridge, Colorado); Marinus Franciscus Antonius Maria van Hest (Golden, Colorado); John A. Conklin (Apalachin, New York) |
| ABSTRACT | Visually undistorted thin film electronic devices are provided. In one embodiment, a method for producing a thin-film electronic device comprises: opening a scribe in a stack of thin film material layers deposited on a substrate to define an active region and an inactive region of the thin-film electronic device, the stack comprising at least one active semiconductor layer. The active region comprises a non-scribed area of the stack and the inactive region comprises a region of the stack where thin film material was removed by the scribe. The method further comprises depositing at least one scribe fill material into a gap opened by the scribe. The scribe fill material has embedded therein one or more coloring elements that alter an optical characteristics spectrum of the inactive region to obtain an optical characteristics spectrum of the active region within a minimum perceptible difference for an industry defined standard observer. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/649440 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 27/301 (20130101) H01L 31/0465 (20141201) H01L 51/0001 (20130101) H01L 51/44 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158235 | Liu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ping Liu (San Diego, California); Yejing Li (San Diego, California) |
| ABSTRACT | A solid-state battery and process of forming the same is provided. The solid-state battery includes a first metal electrode. The solid-state battery includes a first mixed conductor disposed on the first metal electrode. The first mixed conductor includes a mixture of ionic and electronic conductors. The solid-state battery includes a pure ionic conductor disposed on the first mixed conductor. The solid-state battery includes a second metal electrode disposed on top of the pure ionic conductor. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 17/437778 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/134 (20130101) H01M 10/0562 (20130101) H01M 10/0565 (20130101) Original (OR) Class H01M 2300/008 (20130101) H01M 2300/0071 (20130101) H01M 2300/0082 (20130101) H01M 2300/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158240 | Armstrong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beth L. Armstrong (Oak Ridge, Tennessee); Gabriel M. Veith (Knoxville, Tennessee); Sergiy Kalnaus (Knoxville, Tennessee); Hsin Wang (Knoxville, Tennessee); Katie L. Browning (Oak Ridge, Tennessee); Kevin M. Cooley (Knoxville, Tennessee) |
| ABSTRACT | A battery includes an anode, a cathode, and a porous separator having a surface and percolating pores providing a porosity of from 20% to 80%. A passively impact resistant composite electrolyte includes an electrolyte and electrically non-conducting particles that enable shear thickening. The particles can have a polydispersity index of no greater than 0.1, an average particle size in a range of from 50 nm to 1 um, and an absolute zeta potential of greater than ±40 mV. The shear thickening enabling particles can be from 10 wt. % to 40 wt. % of the total weight of the separator and shear thickening particles. Between 20-40 wt. % of the shear thickening enabling particles are located in the pores of the separator. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570972 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 41/88 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 2300/0028 (20130101) H01M 2300/0085 (20130101) H01M 2300/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158302 | Carlson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Optodot Corporation (Devens, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Steven A. Carlson (Cambridge, Massachusetts); Ifenna Kingsley Anakor (Allston, Massachusetts); Greg Robert Farrell (Sudbury, Massachusetts) |
| ABSTRACT | Provided are separators for use in an electrochemical cell comprising (a) an inorganic oxide and (b) an organic polymer, wherein the inorganic oxide comprises organic substituents. Also provided are electrochemical cells comprising such separators. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590394 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 14/303 (20130101) C04B 24/00 (20130101) C04B 24/023 (20130101) C04B 26/06 (20130101) C04B 38/0074 (20130101) C04B 2111/00612 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 50/409 (20210101) H01M 50/411 (20210101) H01M 50/431 (20210101) H01M 50/446 (20210101) Original (OR) Class Technical Subjects Covered by Former US Classification Y10T 29/49115 (20150115) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158497 | Babakhani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Aydin Babakhani (Los Angeles, California); Hamed Rahmani (Princeton, New Jersey); Hidemasa Mitsui (Santa Clara, California) |
| ABSTRACT | Systems and methods for utilizing a small form-factor, wirelessly powered transceiver are disclosed. In one embodiment, a wireless powered transceiver includes a receive antenna configured to receive a receive signal, a transmit antenna configured to transmit a transmit signal, a power harvesting system including a rectifier circuit configured convert radio frequency energy from the receive signal into DC (direct current) voltage, and a power management unit (PMU) configured to set the operating mode and biasing condition of the receive and transmit circuitry blocks and provide DC voltage from the receive circuitry block to the transmit circuitry block to maintain a minimum voltage, a receiver circuitry block configured to provide energy from the receive signal to the power harvesting system, and a transmitter circuitry block including a data modulator circuit, the data modulator circuit configured to generate the transmit signal using DC voltage received from the power management unit. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/456328 |
| CURRENT CPC | Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 50/001 (20200101) H02J 50/27 (20160201) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220159387 | Zhou et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Qin Zhou (Fremont, California); Alexander K. Zettl (Kensington, California) |
| ABSTRACT | This disclosure provides a device that includes a graphene membrane and a first electrode proximate a first side of the graphene membrane, the first electrode being electrically conductive. The device further includes a frame comprising a first part and a second part, wherein the graphene membrane is suspended between the first part and the second part. The device is configured to have a frequency response across a frequency range at least from 20 Hz to 20 kHz or across the entire human audible frequency range. The device is a microphone or a loudspeaker. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590674 |
| CURRENT CPC | Loudspeakers, Microphones, Gramophone Pick-ups or Like Acoustic Electromechanical Transducers; Deaf-aid Sets; Public Address Systems H04R 19/02 (20130101) H04R 19/005 (20130101) Original (OR) Class H04R 23/002 (20130101) H04R 29/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220152012 | Kashyap et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Moti Lal Kashyap (Rancho Palos Verdes, California); Vaijinath Kamanna (Irvine, California); Shobha Kamanna (Irvine, California) |
| ABSTRACT | The disclosure provides methods to reverse or regress fibrosis and/or liver cirrhosis in a subject in need thereof, using high-dose (pharmacologic) niacin, or a niacin analog thereof. |
| FILED | Tuesday, November 16, 2021 |
| APPL NO | 17/528173 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/455 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152211 | PANDA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia); THE US GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| ASSIGNEE(S) | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (Augusta, Georgia); THE US GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (Washington, District of Columbia) |
| INVENTOR(S) | Siva S. PANDA (Martinez, Georgia); Muthusamy THANGARAJU (Evans, Georgia); Balakrishna L. LOKESHWAR (North Augusta, South Carolina) |
| ABSTRACT | Hybrid curcumin-based conjugates and methods of use thereof are provided. Pharmaceutical compositions including an effective amount of one or more curcumin conjugates are also provided. In particular embodiments, the compositions are formulated for oral delivery. The conjugates and pharmaceutical compositions thereof can be administered to a subject in need thereof to treat cancer. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/525473 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/55 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152431 | Iaquinto et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Iaquinto (Seattle, Washington); Alexander Berardo-Cates (Seattle, Washington); Arrianna Willis (Seattle, Washington); Darren Li (Seattle, Washington) |
| ABSTRACT | A respiratory device for covering a head of a wearer can comprise a head engagement element. A hood can define an interior and a rim. The hood can comprise a rim that is configured to bias against the head of the wearer to inhibit air communication therebetween. At least a portion of the hood can be transparent. A hose fitting can be operatively coupled to the hood to provide air therethrough into the interior of the hood. The hood can be configured to be releasably coupled to the head engagement element at a plurality of positions. The plurality of positions can comprise a forward position and a rear position that is spaced from the forward position by at least one inch along an anteroposterior adjustment axis. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/530558 |
| CURRENT CPC | Outerwear; Protective Garments; Accessories A41D 13/1153 (20130101) A41D 2200/20 (20130101) A41D 2300/32 (20130101) A41D 2500/52 (20130101) Devices, Apparatus or Methods for Life-saving A62B 17/001 (20130101) A62B 17/04 (20130101) Original (OR) Class A62B 17/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153685 | Chen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Pittsburg-Of the Commonealth System of Higher Education (Pittsburgh, Pennsylvania); The United States as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beibei Chen (Pittsburgh, Pennsylvania); Rama K. Mallampalli (Solon, Iowa); Yuan Liu (Pittsburgh, Pennsylvania) |
| ABSTRACT | Described herein are compounds that disrupt the interaction between Fbxo48 and phosphorylated-AMPK. |
| FILED | Thursday, May 06, 2021 |
| APPL NO | 17/313577 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Acyclic or Carbocyclic Compounds C07C 215/08 (20130101) C07C 215/18 (20130101) C07C 217/34 (20130101) Original (OR) Class Heterocyclic Compounds C07D 205/04 (20130101) C07D 217/04 (20130101) C07D 311/88 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154188 | HOWELL et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The United States Government As Represented By The Department of Veterans Affairs (Washington, District of Columbia); Trustees of Dartmouth College (Hanover, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexandra L. HOWELL (Lyme, New Hampshire); Susan K. ESZTERHAS (Plainfield, New Hampshire) |
| ABSTRACT | Methods and kits for excising HIV-1 DNA in vivo are provided, which employ Clustered Regularly Interspaced Short Palindromic Repeats (CRIS-PR) and CRISPR-Associated (cas) proteins. Vectors harboring nucleic acids encoding one or more guide RNA, wherein said guide RNA hybridizes with a target |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590560 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) A61K 38/1709 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 15/1132 (20130101) Original (OR) Class C12N 2320/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220153597 | PILLA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CLEMSON UNIVERSITY (Clemson, South Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | SRIKANTH PILLA (CLEMSON, South Carolina); MORTEZA SABET (CLEMSON, South Carolina); APPARAO M. RAO (CLEMSON, South Carolina); NANCY CHEN (CLEMSON, South Carolina) |
| ABSTRACT | Methods for synthesis of high surface area porous silicon-based materials and structures that can be formed according to the methods are described. Methods are scalable and capable of producing large quantities of the high surface area materials with high efficiency. The high surface area products can be in the form of a 3D network of interconnected arms or quills with multimodal porosity including high level pores between and among arms, hollow cores of the arms of the network, and pores through the walls of the arms of the network. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/525497 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 30/00 (20130101) Non-metallic Elements; Compounds Thereof; C01B 33/20 (20130101) C01B 33/149 (20130101) Original (OR) Class Indexing Scheme Relating to Structural and Physical Aspects of Solid Inorganic Compounds C01P 2006/12 (20130101) C01P 2006/14 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/386 (20130101) H01M 4/8626 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220154728 | Evans et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Technologies Corporation (Farmington, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Simon W. Evans (Farmington, Connecticut); Yuan Dong (Glastonbury, Connecticut); Sean Nolan (Wethersfield, Connecticut) |
| ABSTRACT | A compressor section for a gas turbine engine includes a blade including a platform, a tip and an airfoil extending between the platform and tip. The airfoil includes a root portion adjacent to the platform, a midspan portion and a tip portion. Each of the root portion, midspan portion and tip portion define a meridional velocity at stage exit with the tip portion including a first meridional velocity greater than a second meridional velocity of the midspan portion. A blade for an axial compressor of a gas turbine engine and a method of operating a compressor section of a gas turbine engine are also disclosed. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590115 |
| CURRENT CPC | Non-positive Displacement Machines or Engines, e.g Steam Turbines F01D 5/145 (20130101) Non-positive-displacement Pumps F04D 19/02 (20130101) F04D 29/324 (20130101) F04D 29/384 (20130101) Original (OR) Class Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2210/30 (20130101) F05D 2220/3216 (20130101) F05D 2240/307 (20130101) F05D 2260/821 (20130101) F05D 2270/3013 (20130101) Climate Change Mitigation Technologies Related to Transportation Y02T 50/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158231 | Smirnova et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | South Dakota Board of Regents (Pierre, South Dakota) |
| ASSIGNEE(S) | South Dakota Board of Regents (Pierre, South Dakota) |
| INVENTOR(S) | Alevtina Smirnova (Rapid City, South Dakota); Matthew Dondelinger (Rapid City, South Dakota); Joel Swanson (Rapid City, South Dakota) |
| ABSTRACT | The present disclosure relates to a manufacturing process of the solid-state glass-ceramic electrolytes, known in the art as antiperovskites. Specifically, the disclosure is focused on manufacturing of the solid-state electrolyte from the corresponding precursors directly on the active electrode surface of an electrochemical device, specifically anode or cathode of the lithium-ion or lithium metal batteries. |
| FILED | Thursday, February 03, 2022 |
| APPL NO | 17/592314 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/661 (20130101) H01M 10/052 (20130101) H01M 10/0562 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158570 | Keplinger et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| ASSIGNEE(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado) |
| INVENTOR(S) | Christoph Matthias Keplinger (Gerlingen, Germany); Shane Karl Mitchell (Boulder, Colorado); Nicholas Alexander Kellaris (Boulder, Colorado); Philipp Rothemund (Boulder, Colorado) |
| ABSTRACT | A hydraulically amplified self-healing electrostatic (HASEL) transducer includes a composite, multi-layered structure. In an example, a HASEL transducer includes a dielectric layer including at least one fluid dielectric layer. The dielectric layer includes a first side and a second side opposing the first side. The HASEL transducer further includes a first electrode disposed at the first side of the dielectric layer, a second electrode disposed at the second side of the dielectric layer, a first outer layer disposed at the first electrode opposite the dielectric layer, and a second outer layer disposed at the second electrode opposite the dielectric layer. The first outer layer and second outer layer exhibit different mechanical and electrical properties from the dielectric layer. |
| FILED | Wednesday, March 04, 2020 |
| APPL NO | 17/436455 |
| CURRENT CPC | Layered Products, i.e Products Built-up of Strata of Flat or Non-flat, e.g Cellular or Honeycomb, Form B32B 27/08 (20130101) B32B 27/36 (20130101) B32B 27/304 (20130101) B32B 2255/10 (20130101) B32B 2255/205 (20130101) B32B 2307/204 (20130101) B32B 2457/00 (20130101) Electric Machines Not Otherwise Provided for H02N 1/002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220158739 | Divsalar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dariush Divsalar (Pasadena, California); William H Farr (Pasadena, California); Makan Mohageg (Pasadena, California); Samuel J Dolinar (Pasadena, California); Matthew D Thill (Pasadena, California) |
| ABSTRACT | Methods and devices implementing a combination of multi-dimensional pulse position modulation (PPM) with wavelength division multiplexing (WDM) or wavelength division multiplexing multiple access (WDMA) for long range space communications are disclosed. The described multi-dimensional PPM scheme can use the laser wavelength and/or polarization as the additional dimension(s) to the time dimension. Through examples it is shown that the disclosed teachings result in a higher photon information efficiency. Various exemplary embodiments are also presented to highlight the applications benefiting from the disclosed methods and devices. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/530258 |
| CURRENT CPC | Transmission H04B 10/54 (20130101) H04B 10/503 (20130101) Original (OR) Class Multiplex Communication H04J 14/005 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 25/4902 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220151135 | Das et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Kansas State University Research Foundation (Manhattan, Kansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sanjoy Das (Manhattan, Kansas); Daniel Flippo (Manhattan, Kansas); Stephen M. Welch (Manhattan, Kansas) |
| ABSTRACT | An autonomous farming system (26) comprising one or more ground-based drones (10) and one or more unmanned aerial vehicles (12), whose routes through a field are optimized by an autonomous farming control system (30) that utilizes linearly constrained integer quadratic programming. The farming system (26) is particularly suited for farming steep terrain that is not accessible to conventional farming equipment. |
| FILED | Friday, April 10, 2020 |
| APPL NO | 17/602014 |
| CURRENT CPC | Soil Working in Agriculture or Forestry; Parts, Details, or Accessories of Agricultural Machines or Implements, in General A01B 69/008 (20130101) Original (OR) Class Aeroplanes; Helicopters B64C 39/02 (20130101) Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 21/3461 (20130101) G01C 21/3469 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/101 (20130101) G05D 2201/0201 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220151259 | Ulmasov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | COVERCRESS INC. (St. Louis, Missouri); BOARD OF TRUSTEES OF ILLINOIS STATE UNIVERSITY (Normal, Illinois); REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tim Ulmasov (St. Louis, Missouri); Gary Hartnell (St. Peters, Missouri); John C. Sedbrook (Bloomington, Illinois); Michael David Marks (Roseville, Minnesota); Ratan Chopra (St. Louis, Missouri); Maliheh Esfahanian (Stanford, California) |
| ABSTRACT | Pennycress seed, seed lots, and seed meal having reduced fiber content and improved suitability for use in producing animal feed are provided. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/643730 |
| CURRENT CPC | Fodder A23K 10/30 (20160501) Original (OR) Class A23K 20/158 (20160501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220152665 | ATHEY |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | En Solución, Inc. (Austin, Texas) |
| ASSIGNEE(S) | En Solución, Inc. (Austin, Texas) |
| INVENTOR(S) | ALEX EDWARD ATHEY (Austin, Texas) |
| ABSTRACT | A system may include a circulation subsystem and a circuit coupled to the circulation subsystem. The circuit may provide one or more signals to control the circulation subsystem to circulate a treatment solution including one or more of microbubbles or nanobubbles in a selected ratio. In one aspect, the nanobubbles may include a first gas, and the microbubbles may include a second gas. In another aspect, the treatment solution may include a first percentage of nanobubbles and a second percentage of microbubbles. In another aspect, mechanical agitation can be applied to the solution on an object to assist in cleaning. |
| FILED | Monday, March 09, 2020 |
| APPL NO | 17/437822 |
| CURRENT CPC | Cleaning in General; Prevention of Fouling in General B08B 1/002 (20130101) B08B 3/08 (20130101) B08B 3/022 (20130101) B08B 3/041 (20130101) B08B 3/102 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220153492 | Liceaga et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Andrea M. Liceaga (West Lafayette, Indiana); Uriel Urbizo-Reyes (West Lafayette, Indiana) |
| ABSTRACT | The present application relates generally to a process of manufacturing an optimized packing material comprising chia seed mucilage (CSM), glycerol, and sorbitol, wherein said packaging materials have a good tensile strength (2.005 N/mm2), lower water vapor permeability (1.73×10−9 g×s×Pa/m), a good flexibility (e.g. high elongation at break, 31.729%). The optimum conditions of polyol concentration were 1.3 g of glycerol and 2.0 g of sorbitol per g of CSM. Based on these results, chia seed mucilage can successfully be used to develop biofilms with potential to be used in drug delivery and edible food coating applications. Both the process and the products are within the scope of this application. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529386 |
| CURRENT CPC | Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 29/238 (20160801) Containers for Storage or Transport of Articles or Materials, e.g Bags, Barrels, Bottles, Boxes, Cans, Cartons, Crates, Drums, Jars, Tanks, Hoppers, Forwarding Containers; Accessories, Closures, or Fittings Therefor; Packaging Elements; Packages B65D 65/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220154156 | Bergonzi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | REGENTS OF THE UNIVERSITY OF MINNESOTA (Minneapolis, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Celine Bergonzi (Le Pecq, France); Mikael Elias (Centerville, Minnesota); Randall Hicks (Duluth, Minnesota); Michael Sadowsky (Roseville, Minnesota); Michael Schwab (Minneapolis, Minnesota) |
| ABSTRACT | Provided herein are lactonases. In one embodiment, the lactonases are metallo-β-lactamase-like lactonase (MLL) enzymes having altered characteristics such as altered catalytic activity and/or altered substrate specificity. Also provided are genetically modified microbes able to express a MLL enzyme, compositions that include a MLL enzyme, and methods of using a MLL enzyme. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 17/437710 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 63/50 (20200101) Biocidal, Pest Repellant, Pest Attractant or Plant Growth Regulatory Activity of Chemical Compounds or Preparations A01P 1/00 (20210801) Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/18 (20130101) Original (OR) Class Enzymes C12Y 301/01081 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220155730 | Ye et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Government of the United States of America as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jun Ye (Louisville, Colorado); Eric G. Oelker (Boulder, Colorado); William R. Milner (Boulder, Colorado); John M. Robinson (Henderson, Nevada); Colin J. Kennedy (Boulder, Colorado); Tobias Bothwell (Boulder, Colorado); Dhruv Kedar (Boulder, Colorado); Terry Brown (Lafayette, Colorado) |
| ABSTRACT | The frequency stability of an optical local oscillator is improved by locking a laser to a silicon Fabry-Perot cavity operating at a temperature near 124 K, where the coefficient of thermal expansion of silicon is near zero. The cavity is mounted inside a cryostat housed in a temperature-stabilized vacuum system that is surrounded by an isolating enclosure and supported by an active vibration platform. Laser light is steered with a superpolished mirror toward a superpolished focusing optic that couples the laser light into the cavity. Light reflected from the cavity is used to stabilize the laser via the Pound-Drever-Hall technique, while light transmitted through the cavity is used to stabilize the laser power. A resonant transimpedance amplifier allows the laser power to be reduced, which reduces heating of the cavity caused by residual absorption of the light. |
| FILED | Friday, December 18, 2020 |
| APPL NO | 17/127616 |
| CURRENT CPC | Time-interval Measuring G04F 5/14 (20130101) Original (OR) Class Automatic Control, Starting, Synchronisation, or Stabilisation of Generators of Electronic Oscillations or Pulses H03L 7/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220156626 | Gorshkov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Government of the United States of America, as represented by the Secretary of Commerce (Gaithersburg, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexey Vyacheslavovich Gorshkov (Rockville, Maryland); Adam Micah Kaufman (Boulder, Colorado); Jeremy Thomas Young (Broomfield, Colorado); Przemyslaw D. Bienias (Silver Spring, Maryland); Ron Belyansky (College Park, Maryland) |
| ABSTRACT | Preparing a metrologically-relevant entangled state includes: providing a plurality of atoms in a regular lattice, wherein each atom is in an initial quantum state of a first state in a ground state manifold; initializing a central atom in the regular lattice to a (|0 |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531652 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/00 (20190101) Original (OR) Class Techniques for Handling Particles or Ionising Radiation Not Otherwise Provided For; Irradiation Devices; Gamma Ray or X-ray Microscopes G21K 1/16 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220159175 | Vemury |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Arun Vemury (North Bethesda, Maryland) |
| ABSTRACT | Systems and methods are disclosed and an example system includes a digital image receiver for receiving a digital image, and an automatic obscuration processor coupled to the image receiver and configured to determine whether the digital image includes a region that classifies as an image of a category of object and, upon a positive determination, to obscure the region and output a corresponding obscured-region digital image. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590583 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 2207/20008 (20130101) G06T 2207/20224 (20130101) Pictorial Communication, e.g Television H04N 5/272 (20130101) H04N 5/2252 (20130101) H04N 5/23219 (20130101) Original (OR) Class H04N 5/23222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220159176 | Vemury |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Arun Vemury (North Bethesda, Maryland) |
| ABSTRACT | Systems and methods are disclosed and an example system includes a digital image receiver for receiving a digital image, and an automatic obscuration processor coupled to the image receiver and configured to determine whether the digital image includes a region that classifies as an image of a category of object and, upon a positive determination, to obscure the region and output a corresponding obscured-region digital image. |
| FILED | Tuesday, February 01, 2022 |
| APPL NO | 17/590626 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 2207/20008 (20130101) G06T 2207/20224 (20130101) Pictorial Communication, e.g Television H04N 5/272 (20130101) H04N 5/2252 (20130101) H04N 5/23219 (20130101) Original (OR) Class H04N 5/23222 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Environmental Protection Agency (EPA)
| US 20220153716 | Chea et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Rowan University (Glassboro, New Jersey) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John D. Chea (Sicklerville, New Jersey); Joseph F. Stanzione, III (Wilmington, Delaware); Kirti M. Yenkie (Glassboro, New Jersey) |
| ABSTRACT | The present disclosure describes a system for the commercial scale extraction of isoflavones from soybean meal. The system includes an optional grinder, an extraction component, a solid-liquid separation component, an acid hydrolysis component, a neutralization component, and a purification component. Also provided are methods of commercial scale extraction of one or more isoflavones from soybean meal. The method includes extracting an isoflavone glucoside from soybean meal, hydrolyzing the isoflavone glucoside to obtain an isoflavone aglycone, neutralizing the isoflavone aglycone, and purifying the isoflavone aglycone. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528805 |
| CURRENT CPC | Heterocyclic Compounds C07D 311/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220153803 | Topp et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana); Monon Bioventures, LLC (Fishers, Indiana) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Elizabeth M. Topp (Dublin, Ireland); Mark L. Heiman (Indianapolis, Indiana) |
| ABSTRACT | Modified glucagon molecules and buffer and/or excipient solutions are provided that result in the glucagon molecules being resistant to oxidation when stored at a substantially neutral pH. Such a modified glucagon molecule includes a substitution at position 27, with the native methionine being replaced with a methionine memetic analog, a norleucine, or an isomer of either of the foregoing. Optionally, the modified glucagon molecules may be further phosphorylated to result in enhanced solubility at a substantially neutral pH and resistance to fibrillation. Methods of using such molecules in pharmaceutical compositions and therapeutic kits are also provided. |
| FILED | Monday, March 16, 2020 |
| APPL NO | 17/439732 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/10 (20180101) Peptides C07K 14/605 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, May 19, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
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FUNDED BY
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Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
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FILED
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APPL NO
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3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
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