FedInvent™ Patent Applications
Application Details for Thursday, May 26, 2022
This page was updated on Monday, May 30, 2022 at 06:48 PM GMT
Department of Health and Human Services (HHS)
| US 20220160050 | CARLSON et al. |
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| FUNDED BY |
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| APPLICANT(S) | Research Triangle Institute (Research Triangle Park, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James B. CARLSON (Durham, North Carolina); Jonathan W. THORNBURG (Durham, North Carolina) |
| ABSTRACT | Apparatus for testing an electronic smoking (e-smoking) device includes an electronic circuit for electronically activating an e-smoking device to convert a wicking fluid therein into a plurality of puffs, and a wireless controller for controlling the electronic circuit. The electronic circuit is configured for activating the e-smoking device based on wireless signals received at the wireless controller. The apparatus is further configured for measuring a characteristic of the e-smoking device, wherein, optionally, the characteristic is a rate of conversion of the wicking fluid to vapor as a function of time for the plurality of puffs. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/669759 |
| CURRENT CPC | Smokers\' Requisites; Match Boxes; Simulated Smoking Devices A24F 40/10 (20200101) A24F 40/80 (20200101) Original (OR) Class Measuring Temperature; Measuring Quantity of Heat; Thermally-sensitive Elements Not Otherwise Provided for G01K 7/02 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 7/0045 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160232 | Wang et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thomas D. Wang (Ann Arbor, Michigan); Xiyu Duan (San Jose, California); Gaoming Li (Ann Arbor, Michigan); Haijun Li (Ann Arbor, Michigan) |
| ABSTRACT | A compact single-axis confocal endomicroscope is provided, capable of complying within 2.8 mm diameter endoscope space requirements. The single-axis confocal endomicroscope uses a folded path design achieved between a fixed mirror and a lateral plane scanning mirror thereby producing a high numerical aperture that allows for diffraction-limited resolution with sub-surface depths. The scanning mirror is formed on a fixed-position, scanning MEMS assembly and has a central aperture that allows for illumination beam expansion in the folded path design. A series of spacers are used to retain beam focusing optical elements in fixed positioned relative to the scanning MEMS assembly for coupling with a single mode fiber. |
| FILED | Wednesday, March 18, 2020 |
| APPL NO | 17/439722 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/07 (20130101) A61B 1/00126 (20130101) A61B 5/0068 (20130101) Original (OR) Class Optical Elements, Systems, or Apparatus G02B 21/0028 (20130101) G02B 21/0032 (20130101) G02B 21/0048 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160237 | Smeltzer et al. |
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| FUNDED BY |
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| APPLICANT(S) | Bioventures, LLC (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark S. Smeltzer (Little Rock, Arkansas); Vladimir Zharov (Little Rock, Arkansas); Ekaterina Galanzha (Little Rock, Arkansas) |
| ABSTRACT | A method of non-invasively detecting and purging bacterial cells using a modified photoacoustic in vivo flow cytometer device is described herein. In particular, a method of detecting bacterial cells by analyzing photoacoustic pulses emitted in response to laser pulses from a pulsed laser source and/or selectively destroying the detected bacterial cells using a non-linear photothermal response induced by a high-energy laser pulse is described herein. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/668909 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0095 (20130101) Original (OR) Class A61B 5/4839 (20130101) A61B 5/14525 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 41/00 (20130101) A61K 49/221 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/007 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/569 (20130101) G01N 33/48728 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160238 | Zharov |
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| FUNDED BY |
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| APPLICANT(S) | Bioventures, LLC (Little Rock, Arkansas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vladimir Pavlovich Zharov (Little Rock, Arkansas) |
| ABSTRACT | A photoacoustic flow cytometry (PAFC) device for the in vivo detection of cells circulating in blood or lymphatic vessels is described. Ultrasound transducers attached to the skin of an organism detect the photoacoustic ultrasound waves emitted by target objects in response to their illumination by at least one pulse of laser energy delivered using at least one wavelength. The wavelengths of the laser light pulse may be varied to optimize the absorption of the laser energy by the target object. Target objects detected by the device may be unlabelled biological cells or cell products, contrast agents, or biological cells labeled with one or more contrast agents. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/668971 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0059 (20130101) A61B 5/0095 (20130101) Original (OR) Class A61B 5/412 (20130101) A61B 5/415 (20130101) A61B 5/416 (20130101) A61B 5/418 (20130101) A61B 5/02007 (20130101) A61B 5/7278 (20130101) A61B 8/08 (20130101) A61B 18/20 (20130101) A61B 2018/207 (20130101) A61B 2018/20361 (20170501) Preparations for Medical, Dental, or Toilet Purposes A61K 49/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 21/39 (20130101) G01N 21/1702 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160264 | SCHERER et al. |
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| FUNDED BY |
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| APPLICANT(S) | CALIFORNIA INSTITUTE OF TECHNOLOGY (Pasadena, California); THE TRUSTEES OF DARTMOUTH COLLEGE (HANOVER, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Axel SCHERER (BARNARD, Vermont); Meisam Honarvar NAZARI (PASADENA, California); Muhammad MUJEEB-U-RAHMAN (SAN GABRIEL, California); Mehmet SENCAN (PASADENA, California); Arti GAUR (HANOVER, New Hampshire) |
| ABSTRACT | A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body. |
| FILED | Wednesday, September 29, 2021 |
| APPL NO | 17/489610 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0031 (20130101) A61B 5/076 (20130101) A61B 5/1451 (20130101) A61B 5/1459 (20130101) A61B 5/1473 (20130101) Original (OR) Class A61B 5/4839 (20130101) A61B 5/14532 (20130101) A61B 5/14546 (20130101) A61B 5/14735 (20130101) A61B 5/14865 (20130101) A61B 17/3468 (20130101) A61B 2560/0219 (20130101) A61B 2562/04 (20130101) A61B 2562/028 (20130101) A61B 2562/125 (20130101) A61B 2562/0209 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 5/172 (20130101) A61M 5/1723 (20130101) A61M 5/14276 (20130101) A61M 2205/3523 (20130101) A61M 2205/8237 (20130101) A61M 2207/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160277 | Mankodi et al. |
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| FUNDED BY |
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| APPLICANT(S) | The United States of America, as Represented by the Secretary, Departmentof Health and Human Servi (Bethesda, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ami Mankodi (Bethesda, Maryland); Andrew Gravunder (Bethesda, Maryland); Thomas Bulea (Bethesda, Maryland); Diane Damiano (Bethesda, Maryland) |
| ABSTRACT | A handgrip device has a palm rest operable to engage with a palm of a user, a grip bar moveably coupled with the palm rest and operable to engage with one or more fingers of a user. One or more force transducers can be disposed between the palm rest and the grip bar to measure a compression rate and the return rate of the grip bar relative to the palm rest, and a data connection operable to communicate the compression rate and the return rate. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/430891 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/225 (20130101) Original (OR) Class A61B 5/702 (20130101) A61B 5/1125 (20130101) A61B 5/7405 (20130101) A61B 2562/0252 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160582 | Wood et al. |
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| FUNDED BY |
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| APPLICANT(S) | DEKA Products Limited Partnership (Manchester, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ryan P. Wood (Bedford, New Hampshire); Michael J. Haynes (Manchester, New Hampshire); Hans Erik Johnson (Salem, New Hampshire); Thaddeus Joseph Hughes (Manchester, New Hampshire); Robert Houston Lawler, JR. (Manchester, New Hampshire) |
| ABSTRACT | A liquid concentrate generation system may comprise a manifold having an inlet receptacle including a first piercing member, an outlet receptacle including a second piercing member, and a flow channel connecting the inlet receptacle and outlet receptacle. The system may further comprise a cartridge having an inlet port and an outlet port sealed by a respective first and second cover. The inlet and outlet port may be respectively configured to displace within the inlet receptacle and outlet receptacle from an unspiked position to a spiked position. First and second piercing members may be in communication with the flow channel and spaced apart respectively from the first and second cover in the unspiked position. The first and second piercing members may be isolated from the flow channel and may respectively puncture the first and second cover in the spiked position. |
| FILED | Friday, September 24, 2021 |
| APPL NO | 17/484425 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 1/10 (20130101) A61J 1/2013 (20150501) Original (OR) Class A61J 1/2037 (20150501) A61J 1/2079 (20150501) A61J 2205/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160632 | Fox et al. |
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| FUNDED BY |
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| APPLICANT(S) | Infectious Disease Research Institute (Seattle, Washington); University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher B. Fox (Sumner, Washington); Susan S. Lin (Kirkland, Washington); Darrick Carter (Seattle, Washington); Neal Van Hoeven (Seattle, Washington); Mayuresh M. Abhyankar (Charlottesville, Virginia); William A. Petri (Charlottesville, Virginia) |
| ABSTRACT | Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided. |
| FILED | Thursday, December 23, 2021 |
| APPL NO | 17/560594 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1271 (20130101) Original (OR) Class A61K 31/739 (20130101) A61K 39/39 (20130101) A61K 2039/55555 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160644 | Nel et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Andre E. Nel (Sherman Oaks, California); Huan Meng (Los Angeles, California); Xiangsheng Liu (Los Angeles, California) |
| ABSTRACT | A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/384214 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 9/127 (20130101) A61K 9/5115 (20130101) Original (OR) Class A61K 9/5123 (20130101) A61K 9/5192 (20130101) A61K 31/4745 (20130101) A61K 45/06 (20130101) A61K 47/62 (20170801) A61K 47/6923 (20170801) A61K 47/6929 (20170801) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/773 (20130101) Y10S 977/906 (20130101) Y10S 977/907 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160678 | LI et al. |
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| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Rong LI (Washington, District of Columbia); Bin YUAN (Hefei City, China PRC); Kate Ida LATHROP (San Antonio, Texas) |
| ABSTRACT | The present invention provides methods and compositions for modulating molecular markers, and hence treating or preventing breast cancer (e.g., triple-negative breast cancer) and melanoma with a pharmaceutically effective amount of S-equol or a pharmaceutical composition comprising S-equol. The S-equol may be administered alone or in combination with one or more cytotoxic or immunotherapeutic compound or molecule. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/535125 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/353 (20130101) Original (OR) Class A61K 39/39541 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160688 | KOLIATSOS et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Vassilis E. KOLIATSOS (Baltimore, Maryland); Nikolaos ZIOGAS (Baltimore, Maryland); Athanasios ALEXANDRIS (Baltimore, Maryland); Jiwon RYU (Baltimore, Maryland) |
| ABSTRACT | This invention relates generally to diseases and conditions characterized with axonal degradation and, more particularly, to methods and compositions for treating or preventing traumatic or degenerative neuropathies and other diseases and conditions involving axonal breakdown/degeneration. |
| FILED | Friday, March 20, 2020 |
| APPL NO | 17/441149 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/444 (20130101) Original (OR) Class A61K 31/4406 (20130101) A61K 31/4409 (20130101) A61K 31/4439 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/02 (20180101) A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160702 | Wagner et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts); The General Hospital Corporation d/b/a Massachusetts General Hospital (Boston, Massachusetts) |
| INVENTOR(S) | Florence Fevrier Wagner (Cambridge, Massachusetts); Jennifer Q. Pan (Cambridge, Massachusetts); Sivaraman Dandapani (Cambridge, Massachusetts); Andrew Germain (Cambridge, Massachusetts); Edward Holson (Cambridge, Massachusetts); Benito Munoz (Cambridge, Massachusetts); Partha P. Nag (Cambridge, Massachusetts); Michael C. Lewis (Cambridge, Massachusetts); Stephen J. Haggarty (Gloucester, Massachusetts); Joshua A. Bishop (Cambridge, Massachusetts); Kimberly Stegmaier (Jamaica Plain, Massachusetts); Michel Weiwer (Cambridge, Massachusetts); Versha Banerji (Winnipeg, Canada) |
| ABSTRACT | The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer. |
| FILED | Thursday, June 10, 2021 |
| APPL NO | 17/344830 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/4745 (20130101) Original (OR) Class A61K 31/4747 (20130101) Heterocyclic Compounds C07D 471/04 (20130101) C07D 471/10 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160703 | FU et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of The University of Texas System (Austin, Texas); Indiana University Research and Technology Corporation (Indianapolis, Indiana); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | The Board of Regents of The University of Texas System (Austin, Texas); Indiana University Research and Technology Corporation (Indianapolis, Indiana); The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| INVENTOR(S) | Yang-Xin FU (Dallas, Texas); Xiumei HUANG (Indianapolis, Indiana); David BOOTHMAN (Deceased, None); Paul J. HERGENROTHER (Urbana, Illinois); Xiaoguang LI (Dallas, Texas); Lingxiang JIANG (Indianapolis, Indiana) |
| ABSTRACT | The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in immunotherapy, particularly where the disease is accompanied by elevated levels of NQO1. In particular, embodiments where an immunotherapy, such as a heckpoint inhibitor, are combined with a NQO1 bioactivatable drug. |
| FILED | Wednesday, March 18, 2020 |
| APPL NO | 17/440787 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/352 (20130101) A61K 31/4745 (20130101) Original (OR) Class A61K 39/3955 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160710 | Ambati |
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| FUNDED BY |
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| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Jayakrishna Ambati (Charlottesville, Virginia) |
| ABSTRACT | Methods for treating and/or inhibiting progression of neurological diseases, conditions, and/or disorders. In some embodiments, the methods include administering to as subject in need thereof a composition that includes a reverse transcriptase inhibitor. Also provided are methods for inhibiting development of amyloid beta peptide (Aβ) in subjects, methods for inhibiting microglial cell death, and composition for use in the presently disclosed methods. |
| FILED | Monday, March 09, 2020 |
| APPL NO | 17/436882 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/513 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/28 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160712 | Turnbaugh et al. |
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| FUNDED BY |
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| APPLICANT(S) | CHAN ZUCKERBERG BIOHUB, INC. (San Francisco, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter Turnbaugh (Oakland, California); Renuka R. Nayak (Oakland, California) |
| ABSTRACT | The present disclosure provides materials and methods for reducing inflammation in the gut and/or joints of a patient, and optionally treating rheumatoid arthritis (RA) and other inflammatory or autoimmune diseases, in a patient. The present disclosure provides such methods based, in part, on the susceptibility of the patient's gut microbiome to methotrexate (MTX) as described herein. |
| FILED | Wednesday, March 10, 2021 |
| APPL NO | 17/198023 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/42 (20130101) A61K 31/52 (20130101) A61K 31/65 (20130101) A61K 31/192 (20130101) A61K 31/519 (20130101) Original (OR) Class A61K 31/573 (20130101) A61K 31/655 (20130101) A61K 31/4706 (20130101) A61K 38/1774 (20130101) A61K 39/3955 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/689 (20130101) C12Q 1/6883 (20130101) C12Q 2600/106 (20130101) C12Q 2600/158 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160723 | Bier et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ethan Bier (La Jolla, None); Prashant Jain (La Jolla, California) |
| ABSTRACT | Methods and compositions for treatment of cell-cell barrier associated conditions, such as caused by anthrax Edema toxin, by inhibiting receptor tyrosine kinase. The present invention provides methods of treating a cell-cell barrier disruption-associated condition in a subject comprising administering to a subject in need thereof a treatment effective amount of an inhibitor of insulin growth factor-1 receptor (IGF-1R) or IGF-1R down stream signaling. |
| FILED | Monday, April 20, 2020 |
| APPL NO | 17/602700 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/44 (20130101) A61K 31/277 (20130101) A61K 31/506 (20130101) A61K 31/5377 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 39/02 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160751 | Huang |
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| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yingqun Huang (East Haven, Connecticut) |
| ABSTRACT | The present invention relates to H19, TET, TGF, HNF, or isoforms thereof, as novel pharmacological targets for the treatment of diseases or disorders, such as cancer, fibrosis, and diabetes, associated with increased TET level, increased H19 level, increased TGF level, or any combination thereof. |
| FILED | Thursday, April 02, 2020 |
| APPL NO | 17/600984 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7105 (20130101) Original (OR) Class A61K 35/76 (20130101) A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160772 | O'Malley et al. |
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| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/650640 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160773 | O'Malley et al. |
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| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/650645 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160791 | Sonnenburg et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Justin L. Sonnenburg (Redwood City, California); Weston R. Whitaker (Daly City, California); Elizabeth Stanley (Portola Valley, California) |
| ABSTRACT | Provided are nucleic acids that include a promoter, where the promoter is operable in a Bacteroides cell and is operably linked to a heterologous nucleotide sequence of interest. Also provided are nucleic acids that include a promoter (operable in a prokaryotic cell such as a Bacteroides cell) operably linked to a sequence encoding a synthetic ribosomal binding site (RBS). Also provided are fusion proteins (and nucleic acids encoding them) in which a secreted Bacteroides polypeptide is fused to a heterologous polypeptide of interest. Also provided are prokaryotic cells (e.g., E. coli, a Bacteroides cell, and the like) that include one more nucleic acids such as those described above. Also provided are methods of expression in a prokaryotic cell, methods of detectably labeling a Bacteroides cell in an animal's gut, and methods of delivering a protein to an individual's gut. |
| FILED | Tuesday, April 18, 2017 |
| APPL NO | 16/094694 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/74 (20130101) Original (OR) Class A61K 38/00 (20130101) Peptides C07K 14/195 (20130101) C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0069 (20130101) C12N 15/52 (20130101) C12N 15/70 (20130101) C12N 15/74 (20130101) C12N 15/90 (20130101) C12N 2795/10043 (20130101) Enzymes C12Y 113/12005 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160799 | ROHWER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION (San Diego, California); THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Forest ROHWER (San Diego, California); Jeremy J. BARR (San Diego, California); J. Bruce GERMAN (San Diego, California) |
| ABSTRACT | Provided are compositions and methods for treating, ameliorating and preventing various infections, disorders and conditions in mammals, including genetically-predisposed and chronic disorders, where a microbial or bacterial flora is at least one causative or symptom-producing factor, where exemplary compositions are products of manufacture, a food, a drink, a nutraceutical, a dietary supplement, a formulation, a pharmaceutical or a pharmaceutical preparation comprising at least one or several of: a plurality of isolated, or substantially purified bacteriophages or prophages, or bacteriophage subunits, a milk, a milk product, milk lipid, milk fat globule (MFG) macromolecule, a milk mucin, a milk glycolipid, a milk free glycan, a milk mucin-like glycoprotein, a milk protein, a milk sugar or lactose, a milk fat or butterfat, a milk vitamin. In alternative embodiment, provided are compositions and methods for treating, preventing or ameliorating an infection, for example, an infection in the gastrointestinal tract, or bowel. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/541063 |
| CURRENT CPC | Dairy Products, e.g Milk, Butter, Cheese; Milk or Cheese Substitutes; Making Thereof A23C 7/04 (20130101) A23C 9/152 (20130101) A23C 9/158 (20130101) A23C 9/206 (20130101) A23C 13/12 (20130101) Fodder A23K 20/10 (20160501) Foods, Foodstuffs, or Non-alcoholic Beverages, Not Covered by Subclasses A23B - A23J; Their Preparation or Treatment, e.g Cooking, Modification of Nutritive Qualities, Physical Treatment; Preservation of Foods or Foodstuffs, in General A23L 2/52 (20130101) A23L 33/10 (20160801) A23L 33/40 (20160801) Indexing Scheme Relating to Foods, Foodstuffs or Non-alcoholic Beverages A23V 2002/00 (20130101) Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Original (OR) Class A61K 45/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160813 | Davisson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Vincent Jo Davisson (West Lafayette, Indiana); Matthew David Bartolowits (West Lafayette, Indiana); Jonathon Michael Gast (Lafayette, Indiana) |
| ABSTRACT | The present invention relates to series of compounds as an inhibitor targeting Proliferating Cell Nuclear Antigen (PCNA). Pharmaceutical compositions of those compounds and methods of using them in the treatment of cancer are within the scope of this disclosure. |
| FILED | Wednesday, August 12, 2020 |
| APPL NO | 16/991534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/06 (20130101) Original (OR) Class A61K 45/06 (20130101) Peptides C07K 5/08 (20130101) C07K 5/0806 (20130101) C07K 5/0812 (20130101) C07K 5/06086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160819 | PEI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dehua PEI (Columbus, Ohio); Ziqing QIAN (Columbus, Ohio) |
| ABSTRACT | Disclosed is a general, reversible bicyclization strategy to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fused with a short cell-penetrating motif and converted into a conformationally constrained bicyclic structure through the formation of a pair of disulfide bonds. The resulting bicyclic peptide has greatly enhanced proteolytic stability as well as cell-permeability. Once inside the cell, the disulfide bonds are reduced to produce a linear, biologically active peptide. This strategy was applied to generate a cell-permeable bicyclic peptidyl inhibitor against the NEMO-IKK interaction. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/538330 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/12 (20130101) Original (OR) Class Peptides C07K 5/10 (20130101) C07K 7/06 (20130101) C07K 7/08 (20130101) C07K 7/50 (20130101) C07K 14/001 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
20220160838 — COMPOSITIONS AND METHODS FOR PROMOTING ISLET VIABILITY AND ENHANCING INSULIN SECRETION
| US 20220160838 | Laurie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| ASSIGNEE(S) | University of Virginia Patent Foundation (Charlottesville, Virginia) |
| INVENTOR(S) | Gordon W. Laurie (Charlottesville, Virginia); Kenneth Brayman (Charlottesville, Virginia); Preeti Chhabra (Waynesboro, Virginia); Mingyang Ma (Charlottesville, Virginia); Karina Teixeira (Charlottesville, Virginia); Thomas R. Gadek (Park City, Utah) |
| ABSTRACT | Compositions and methods for regenerating pancreatic islet viability and/or cell proliferation in vitro, ex vivo, and/or in vivo; and/or for regenerating glucose-stimulated insulin secretion; and/or for regenerating viability and/or cell proliferation of a transplanted pancreatic islets; and/or for preventing and/or inhibiting rejection of a transplanted islets; and/or for pancreatic islet transplantation; and/or for treating a symptom of a condition, disorder, or disease associated with abnormal insulin responsiveness to glucose are provided. In some embodiments, the compositions include a peptide and/or a pharmaceutically acceptable salt thereof, and/or a biologically active fragment, analog, or derivative thereof, wherein the peptide, the pharmaceutically acceptable salt thereof, and/or the biologically active fragment, analog, or derivative thereof has an amino acid sequence of any of SEQ ID NOs: 1-60, or any combination thereof. |
| FILED | Friday, March 13, 2020 |
| APPL NO | 17/438760 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/39 (20130101) A61K 38/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160846 | Omary et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bishr Omary (Ann Arbor, Michigan); Min-Jung Park (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are compositions methods for the treatment and/or prevention of tissue or internal organ injury. In particular, carbamoyl phosphate synthatase-1 (CPS-1) peptides and polypeptides (e.g., enzymatically active or inactive CPS-1 peptides and polypeptides), and methods of use thereof for the treatment and/or prevention of disease that results in tissue injury are provided. |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 17/433011 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/53 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 29/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160852 | Gaensler |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Karin Gaensler (Oakland, California) |
| ABSTRACT | Provided herein, inter alia, nucleic acids including coding sequences for human CD80, IL-15, IL-15Rα polypeptides, wherein the coding sequence for hCD80 is operably positioned upstream to the coding sequences for hIL-15 and hIL-15Rα. The disclosure also provides recombinant cells, cell cultures, pharmaceutical compositions, and whole-cell vaccines containing the recombinant cells disclosed herein. Also disclosed are methods useful for treating myeloma and leukemias, such as acute myelogenous leukemia (AML). |
| FILED | Friday, April 03, 2020 |
| APPL NO | 17/600588 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/00114 (20180801) Original (OR) Class A61K 39/001111 (20180801) A61K 39/001119 (20180801) A61K 2039/5156 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Peptides C07K 14/005 (20130101) C07K 14/5443 (20130101) C07K 14/7155 (20130101) C07K 14/70532 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160857 | KOLLS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Administrators of the Tulane Educational Fund (New Orleans, Louisiana); University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | The Administrators of the Tulane Educational Fund (New Orleans, Louisiana); University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh, Pennsylvania) |
| INVENTOR(S) | Jay KOLLS (New Orleans, Louisiana); Elizabeth NORTON (New Orleans, Louisiana); Kong CHEN (Pittsburgh, Pennsylvania) |
| ABSTRACT | The present disclosure describes multivalent antibacterial vaccines for the treatment of bacterial infections, such as Klebsiella, E. coli and E. cloacae, as well as therapy-resistant forms thereof. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 17/601051 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/0266 (20130101) Original (OR) Class A61K 2039/55544 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160872 | Yadavalli et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tejabhiram Yadavalli (Chicago, Illinois); Deepak Shukla (Chicago, Illinois) |
| ABSTRACT | The present disclosure relates to compositions and drug delivery systems comprising highly porous activated carbon (HPAC) and a therapeutic agent and methods of treating a disorder using these compositions and drug delivery systems. The present disclosure also provides for methods of treating viral infections with HPAC or therapeutic agents adsorbed within HPAC and methods of eliciting an immune response comprising administering a live, live-attenuated virus or virion adsorbed to HPAC. |
| FILED | Wednesday, April 08, 2020 |
| APPL NO | 17/601449 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0004 (20130101) A61K 9/0034 (20130101) A61K 31/522 (20130101) A61K 45/06 (20130101) A61K 47/02 (20130101) Original (OR) Class A61K 47/6929 (20170801) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/22 (20180101) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160878 | Cloyd |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Regents of the University of Minnesota (St. Paul, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | James C. Cloyd (Edina, Minnesota) |
| ABSTRACT | The present invention is directed to compositions comprising topiramate and a sulfoalkyl ether cyclodextrin, and methods of making and using the same. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/384616 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 31/357 (20130101) A61K 31/724 (20130101) A61K 47/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160884 | ZHANG |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHEASTERN UNIVERSITY (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ke ZHANG (Natick, Massachusetts) |
| ABSTRACT | Monodisperse structures with precise numbers of polymer arms and oligonucleotide chains conjugated to a backbone are disclosed. The structures, referred to miktoarm conjugates, are resistant to nuclease degradation and are capable of regulating gene expression in the absence of a co-carrier. |
| FILED | Tuesday, April 07, 2020 |
| APPL NO | 17/602307 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) Original (OR) Class A61K 47/549 (20170801) A61K 47/6929 (20170801) A61K 49/0032 (20130101) A61K 49/0054 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/111 (20130101) C12N 2310/11 (20130101) C12N 2310/51 (20130101) C12N 2310/351 (20130101) C12N 2320/32 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160885 | Shih et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts); Dana-Farber Cancer Institute, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | William M. Shih (Cambridge, Massachusetts); Zhao Zhao (Cambridge, Massachusetts); Frances M. Anastassacos (Cambridge, Massachusetts) |
| ABSTRACT | The present disclosure provides, in some aspects, nucleic acid nanostructures covalently linked to oligolysine-PEG copolymers. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 17/602740 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/60 (20170801) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160891 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan J. Green (Baltimore, Maryland); Stephany Yi Tzeng (Baltimore, Maryland); Kelly Rhodes (Baltimore, Maryland); Giorgio Raimondi (Baltimore, Maryland); Marcos Iglesias (Baltimore, Maryland); Jamie Spangler (Baltimore, Maryland); Jakub Tomala (Baltimore, Maryland); Derek VanDyke (Baltimore, Maryland); Randall A. Meyer (Baltimore, Maryland) |
| ABSTRACT | The disclosure is directed to a biodegradable particle comprising a polyester or polyester blend, a first protein that binds to an immune cell, and a second protein that promotes proliferation and/or activation of immune cells, and a third soluble protein or small molecule encapsulated within the particle. The second protein is a fusion protein comprising at least a portion of an antibody and at least a portion of a cytokine (i.e., an immunocytokine). The disclosure also is directed to methods for treating a disease or condition in a subject (e.g., an autoimmune disease) comprising administering the aforementioned biodegradable particle to the subject. |
| FILED | Monday, April 13, 2020 |
| APPL NO | 17/602856 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5031 (20130101) A61K 31/436 (20130101) A61K 47/62 (20170801) A61K 47/6813 (20170801) A61K 47/6845 (20170801) A61K 47/6849 (20170801) A61K 47/6937 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160903 | Lu et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CASE WESTERN RESERVE UNIVERSITY (CLEVELAND, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zheng-Rong Lu (Cleveland, Ohio); Songqi Gao (Cleveland, Ohio) |
| ABSTRACT | A PET/SPECT probe includes the following formula: P—1,—C wherein P is a EDB-FN targeting peptide, C is a PET/SPECT contrast agent; and L is an optional linker that covalently links the peptide to the contrast agent. |
| FILED | Friday, January 17, 2020 |
| APPL NO | 17/424104 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/088 (20130101) A61K 51/0474 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160904 | Strong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Roland K. Strong (Seattle, Washington); Peter Rupert (Seattle, Washington); Rebecca J. Abergel (Berkeley, California); Ilya Captain (Moraga, California); Gauthier JP Deblonde (Berkeley, California) |
| ABSTRACT | Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/643734 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0478 (20130101) A61K 51/0482 (20130101) Original (OR) Class Separation B01D 15/34 (20130101) B01D 15/3804 (20130101) Peptides C07K 14/47 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 60/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160906 | BENNETT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Washington University (St. Louis, Missouri) |
| ASSIGNEE(S) | Washington University (St. Louis, Missouri) |
| INVENTOR(S) | Kevin BENNETT (St. Louis, Missouri); Edwin BALDELOMAR (St. Louis, Missouri) |
| ABSTRACT | Among the various aspects of the present disclosure is the provision of methods and compositions for detecting recombinant cationic ferritin imaging agents. Also provided are transgenic microorganisms capable of synthesizing a recombinant ferritin imaging agent and methods of making the same. The imaging agents described herein can be used to effectively and noninvasively detect renal pathologies and are suitable for use in a number of imaging modalities. |
| FILED | Thursday, March 05, 2020 |
| APPL NO | 17/434800 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/14 (20130101) A61K 51/08 (20130101) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 13/12 (20180101) Peptides C07K 14/435 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/62 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160929 | Daristotle et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Maryland, College Park (College Park, Maryland); Children's National Medical Center (Washington, District of Columbia) |
| ASSIGNEE(S) | University of Maryland, College Park (College Park, Maryland); Children's National Medical Center (Washington, District of Columbia) |
| INVENTOR(S) | John Daristotle (Bel Air, Maryland); Shadden Zaki (Bethesda, Maryland); Peter Kofinas (North Bethesda, Maryland); Anthony Sandler (Bethesda, Maryland); Lung Lau (Washingtron, District of Columbia); Leopoldo Torres (Greenbelt, Maryland) |
| ABSTRACT | The present disclosure relates to a biocompatible composition comprising a solution of low molecular weight polymer and high molecular weight polymer. The present disclosure also relates to biocompatible compositions comprising poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG), and additionally including a suspension of silica particles and/or a therapeutic agent. The present disclosure is also directed to biocompatible polymer fiber constructs formed from the disclosed compositions, methods of fabrication thereof, and uses of such constructs and compositions. |
| FILED | Tuesday, March 10, 2020 |
| APPL NO | 17/437280 |
| CURRENT CPC | Methods or Apparatus for Sterilising Materials or Objects in General; Disinfection, Sterilisation, or Deodorisation of Air; Chemical Aspects of Bandages, Dressings, Absorbent Pads, or Surgical Articles; Materials for Bandages, Dressings, Absorbent Pads, or Surgical Articles A61L 24/0015 (20130101) Original (OR) Class A61L 24/046 (20130101) A61L 24/0073 (20130101) A61L 26/0019 (20130101) A61L 26/0066 (20130101) A61L 26/0076 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161013 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTHWESTERN UNIVERSITY (EVANSTON, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Daniel Y. Zhang (Lisle, Illinois); Roger Stupp (Chicago, Illinois); Adam M. Sonabend Worthalter (Chicago, Illinois) |
| ABSTRACT | A method for treating central nervous system tumors is a patient comprising: treating the patient intravenously with therapeutic agent including Cremophor EL-free paclitaxel, and disrupting a blood-brain barrier within the brain of the patient by the use of an ultrasound device and intravenous microbubble injection. In other methods, the subject is treated with a therapeutic agent comprising an albumin-bound paclitaxel that crosses the blood brain barrier. In this manner, the disruption of the blood-brain barrier increases the concentration of paclitaxel in the brain as compared to the concentration of paclitaxel in the brain without blood-brain barrier disruption and intravenous microbubble injection. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 17/599313 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0009 (20130101) A61K 9/0085 (20130101) A61K 31/337 (20130101) Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 37/0092 (20130101) Original (OR) Class A61M 2205/04 (20130101) A61M 2210/0693 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161027 | Aycock et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Virginia Tech Intellectual Properties Inc. (Blacksburg, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth N. Aycock (Blacksburg, Virginia); Rafael V. Davalos (Blacksburg, Virginia) |
| ABSTRACT | High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing bursts of electrical pulses in a positive phase-interphase delay-negative phase-interpulse delay pattern. Despite accumulating evidence suggesting the significance of these delays, their effects on therapeutic outcomes from clinically-relevant H-FIRE waveforms have not been studied extensively. The present invention provides methods of pulse delivery, including delays, that mitigate bubble formation and/or minimize the risk of arcing, such as due to the presence of bubbles, and/or minimize muscle stimulation are described herein. |
| FILED | Friday, November 26, 2021 |
| APPL NO | 17/535742 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 2018/00613 (20130101) Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/327 (20130101) Original (OR) Class A61N 1/0416 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161042 | Lu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Daniel C. Lu (Los Angeles, California) |
| ABSTRACT | In various embodiments methods and devices are provided for facilitating locomotor function and/or voiding of bladder and/or bowel in a subject with a neuromotor disorder. In certain embodiments the methods involve providing magnetic stimulation of the spinal cord at a location, frequency and intensity sufficient to facilitate locomotor function and/or voiding of bladder and/or bowel. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/381156 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36017 (20130101) A61N 1/36034 (20170801) A61N 2/02 (20130101) A61N 2/004 (20130101) A61N 2/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161052 | Vartanian et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENT OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Garen V. Vartanian (Ann Arbor, Michigan); Kwoon Y. Wong (Ann Arbor, Michigan); Pei-Cheng Ku (Ann Arbor, Michigan); Scott A. Almburg (Redford Township, Michigan) |
| ABSTRACT | A light source and a method of generating a light using the light source is disclosed. The light source is configured to produce a plurality of distinct colors in generating the light, one of the distinct colors falling within a blue spectral light band. A light controller modulates the spectral light produced by the plurality of distinct colors. The modulation provides melanopsin contrast in order to increase melanopsin responsiveness of a subject exposed to the generated light and maintains the color temperature, color quality, and color constancy experienced by the subject in a lit viewing environment within an acceptable range. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/669134 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 5/0618 (20130101) Original (OR) Class A61N 5/0622 (20130101) A61N 2005/0626 (20130101) A61N 2005/0652 (20130101) A61N 2005/0663 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161263 | Paulovich et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington) |
| INVENTOR(S) | Amanda G. Paulovich (Seattle, Washington); Richard Ivey (Federal Way, Washington); Jacob Kennedy (Seattle, Washington); Travis Lorentzen (Bothell, Washington); Amanda Woodcock (Seattle, Washington); Scott C. Thielman (Seattle, Washington); Elijah E. Hooper (Seattle, Washington) |
| ABSTRACT | Devices and methods for bio-specimen refrigeration are provided. In an embodiment, the bio-specimen refrigeration devices of the present disclosure include a housing having a lid and a base portion, wherein the lid is selectively moveable between an open position and a closed position; a coolant cartridge chamber disposed in the housing and configured to fluidically couple with a coolant cartridge disposed in the coolant cartridge chamber; and a cooling chamber disposed in the housing and configured to receive a fluid coolant from the coolant cartridge, wherein in the closed position, the lid seals the cooling chamber. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531260 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 7/00 (20130101) Original (OR) Class B01L 2200/04 (20130101) B01L 2200/0689 (20130101) B01L 2300/1894 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162070 | Silkoff et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| ASSIGNEE(S) | Third Pole, Inc. (Waltham, Massachusetts) |
| INVENTOR(S) | Philip E. Silkoff (Philadelphia, Pennsylvania); Wolfgang Scholz (Beverly, Massachusetts); Sweta Patel (Waltham, Massachusetts) |
| ABSTRACT | Systems and methods for generating nitric oxide are disclosed. A nitic oxide (NO) generation system includes at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas; and a controller configured to regulate the amount of nitric oxide in the product gas produced by the at least one pair of electrodes by utilizing duty cycle values of plasma pulses selected from a plurality of discrete duty cycles to produce a target rate of NO production based on an average of discrete production rates associated with each of the plurality of discrete duty cycles. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/670655 |
| CURRENT CPC | Devices for Introducing Media Into, or Onto, the Body; Devices for Transducing Body Media or for Taking Media From the Body; Devices for Producing or Ending Sleep or Stupor A61M 16/10 (20130101) A61M 16/0666 (20130101) A61M 2202/0208 (20130101) A61M 2202/0275 (20130101) Non-metallic Elements; Compounds Thereof; C01B 21/203 (20130101) Original (OR) Class Electric Discharge Tubes or Discharge Lamps H01J 37/04 (20130101) H01J 37/32146 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162157 | Wang et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Regents of the University of Oklahoma (Norman, Oklahoma) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Weidong Wang (Edmond, Oklahoma); Venkateswararao Eeda (Oklahoma City, Oklahoma) |
| ABSTRACT | Benzylamino-oxoethyl benzamide compounds for use in treating diseases and conditions associated with abnormal cell function related to endoplasmic reticulum (ER) stress. For example, the compounds can be used as suppressors of ER stress-induced pancreatic β-cell dysfunction and death, for example in the treatment of Type 1 and Type 2 diabetes. The compounds can also be used in treatments for chronic heart disease, neurodegenerative diseases, retinal degeneration, and other metabolic disorders associated with ER stress. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/666692 |
| CURRENT CPC | Acyclic or Carbocyclic Compounds C07C 233/73 (20130101) Original (OR) Class Heterocyclic Compounds C07D 317/54 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162167 | NEAMATI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nouri NEAMATI (Ann Arbor, Michigan); Shuai MAO (Ann Arbor, Michigan) |
| ABSTRACT | This invention is in the field of medicinal chemistry. In particular, the invention relates to small molecule compounds having bicyclic and tetracyclic quinone scaffolds which have antiproliferative activities through, for example, induction of reactive oxygen species. The invention further processes for preparing, and methods for using these compounds to treat cancer (e.g., pancreatic cancer, leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer). |
| FILED | Friday, March 06, 2020 |
| APPL NO | 17/436258 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/496 (20130101) A61K 31/4709 (20130101) A61K 31/5377 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/02 (20180101) Heterocyclic Compounds C07D 215/38 (20130101) Original (OR) Class C07D 401/12 (20130101) C07D 417/12 (20130101) C07D 471/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162173 | Ginty et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| INVENTOR(S) | David D. Ginty (Cambridge, Massachusetts); Lauren L. Orefice (Cambridge, Massachusetts); Jinbo Lee (Cambridge, Massachusetts) |
| ABSTRACT | The present invention provides novel peripherally-restricted benzodiazepines with reduced blood brain barrier permeability and methods of use thereof for reducing tactile dysfunction, social impairment, and anxiety in a subject diagnosed with Autism Spectrum Disorder, Rett syndrome, Phelan McDermid syndrome, or Fragile X syndrome. |
| FILED | Wednesday, March 25, 2020 |
| APPL NO | 17/442474 |
| CURRENT CPC | Heterocyclic Compounds C07D 243/24 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162182 | DEVITA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Robert J. DEVITA (New York, New York); Andrew F. STEWART (New York, New York); Chalada SUEBSUWONG (New York, New York); Kunal KUMAR (New York, New York); Peng WANG (New York, New York); Roberto J. SANCHEZ (New York, New York); Hui WANG (New York, New York) |
| ABSTRACT | Disclosed herein are kinase inhibitor compounds having structure (I), or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, R3, R4, R5, R6, R7, X, Y, Z, and (AA) are as defined herein. Also disclosed are compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder. |
| FILED | Tuesday, December 31, 2019 |
| APPL NO | 17/418388 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/04 (20130101) Original (OR) Class C07D 401/14 (20130101) C07D 405/14 (20130101) C07D 409/14 (20130101) C07D 413/14 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162186 | GANESH et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Emory University (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Thota GANESH (Atlanta, Georgia); Raymond J. DINGLEDINE (Atlanta, Georgia); Radhika AMARADAHI (Atlanta, Georgia); Shabber MOHAMMED (Atlanta, Georgia) |
| ABSTRACT | The disclosure relates to Prostnglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, epilepsy, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof. |
| FILED | Thursday, March 19, 2020 |
| APPL NO | 17/440437 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Heterocyclic Compounds C07D 401/14 (20130101) Original (OR) Class C07D 403/12 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162188 | WILLIAMS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NORTH CAROLINA STATE UNIVERSITY (Raleigh, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Gavin WILLIAMS (Raleigh, North Carolina); Sean LUND (Raleigh, North Carolina); Rachael HALL (Raleigh, North Carolina) |
| ABSTRACT | Disclosed are methods for preparing isoprenoid subunits, as well as methods of employing these isoprenoid subunits for the synthesis of isoprenoids. Also provided are isoprenoids prepared using the methods described herein. |
| FILED | Wednesday, January 15, 2020 |
| APPL NO | 17/423316 |
| CURRENT CPC | Heterocyclic Compounds C07D 401/14 (20130101) C07D 403/06 (20130101) Original (OR) Class C07D 403/14 (20130101) C07D 405/14 (20130101) C07D 409/14 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 17/165 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162202 | Roberts et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Scripps Research Institute (La Jolla, California); BlackThorn Therapeutics, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward Roberts (Fallbrook, California); Miguel A. Guerrero (San Diego, California); Mariangela Urbano (Del Mar, California); Hugh Rosen (La Jolla, California); Robert M. Jones (South San Francisco, California); Candace Mae Laxamana (South San Francisco, California); Xianrui Zhao (South San Francisco, California); Eric Douglas Turtle (Belmont, California) |
| ABSTRACT | Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof. wherein X, Y, R1, R2, R4, R5, R6, R7, R8 and R11 are as defined herein. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390531 |
| CURRENT CPC | Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 25/00 (20180101) A61P 25/06 (20180101) Heterocyclic Compounds C07D 413/14 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162209 | Tan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); Research Foundation of the City University of New York (New York, New York); The Johns Hopkins University (Baltimore, Maryland) |
| ASSIGNEE(S) | Memorial Sloan-Kettering Cancer Center (New York, New York); Research Foundation of the City University of New York (New York, New York); The Johns Hopkins University (Baltimore, Maryland) |
| INVENTOR(S) | Derek Shieh Tan (New York, New York); Lisa Charlotte Standke (New York, New York); Luis Edmundo Nereo Quadri (New York, New York); Glennon Valere Bythrow (Chicago, Illinois); William Ramses Bishai (Baltimore, Maryland); Shichun Lun (Ellicott City, Maryland) |
| ABSTRACT | Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts or tautomers thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment and/or prevention of an infectious disease (e.g., bacterial infection (e.g., Mycobacterium infection (e.g., tuberculosis)). (I) |
| FILED | Friday, December 20, 2019 |
| APPL NO | 17/416976 |
| CURRENT CPC | Heterocyclic Compounds C07D 473/18 (20130101) C07D 473/30 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162241 | Berkman et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Cancer Targeted Technology LLC (Woodinville, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Clifford Berkman (Pullman, Washington); Cindy Choy (Pullman, Washington) |
| ABSTRACT | Provided herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. Also provided are compositions including a compound of Formula (I) together with a pharmaceutically acceptable carrier, and methods for imaging prostate cancer cells. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/528571 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/048 (20130101) A61K 51/0406 (20130101) A61K 51/0478 (20130101) A61K 51/0485 (20130101) A61K 51/0489 (20130101) Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 9/24 (20130101) C07F 9/5532 (20130101) C07F 9/6524 (20130101) C07F 9/6561 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162254 | Kerr et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation For The State University Of New York (Albany, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | William G. Kerr (Syracuse, New York); John D. Chisholm (Syracuse, New York) |
| ABSTRACT | The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/542090 |
| CURRENT CPC | Steroids C07J 1/0007 (20130101) Original (OR) Class C07J 41/0005 (20130101) C07J 41/0011 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162265 | CHEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNIVERSITY OF WASHINGTON (Seattle, Washington) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Zibo CHEN (Seattle, Washington); David BAKER (Seattle, Washington); Frank DIMAIO (Seattle, Washington) |
| ABSTRACT | Disclosed herein are polypeptides that serve as building blocks that can be used, for example, to design 2D protein arrays, methods for designing such polypeptides, and methods for their use. |
| FILED | Tuesday, April 14, 2020 |
| APPL NO | 17/598641 |
| CURRENT CPC | Peptides C07K 14/001 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 15/20 (20190201) G16B 20/30 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162272 | Hu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE METHODIST HOSPITAL (Houston, Texas) |
| ASSIGNEE(S) | THE METHODIST HOSPITAL (Houston, Texas) |
| INVENTOR(S) | Ye Hu (Scottsdale, Arizona); Chang Liu (Lexington, South Carolina); Xin Ma (Pearland, Texas); Yaojun Li (Houston, Texas) |
| ABSTRACT | Provided herein are nanoparticles configured for the rapid detection of disease-specific peptides from patient samples, including blood-based samples. Also provided are methods of measuring the level of an infection by isolation and quantification of disease-specific peptides from patient samples. The nanoparticles may act as a co-matrix for matrix assisted laser desorption/ionization mass spectrometry. |
| FILED | Friday, December 03, 2021 |
| APPL NO | 17/541365 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/61 (20170801) A61K 47/6425 (20170801) Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 5/00 (20130101) Peptides C07K 14/35 (20130101) Original (OR) Class Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/56972 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162278 | Omary et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Michigan (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bishr Omary (Ann Arbor, Michigan); Min-Jung Park (Ann Arbor, Michigan) |
| ABSTRACT | Provided herein are compositions methods for the treatment and/or prevention of liver injury. In particular, carbamoyl phosphate synthetase-1 (CPS-I) peptides and polypeptides (e.g., enzymatically active or inactive CPS-I peptides and polypeptides), and methods of use thereof for the treatment and/or prevention of liver injury are provided. |
| FILED | Thursday, February 27, 2020 |
| APPL NO | 17/433009 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 1/16 (20180101) Peptides C07K 14/52 (20130101) Original (OR) Class Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) Enzymes C12Y 603/04016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162283 | Antipov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Silver Creek Pharmaceuticals, Inc. (San Francisco, California) |
| ASSIGNEE(S) | Silver Creek Pharmaceuticals, Inc. (San Francisco, California) |
| INVENTOR(S) | Laura D.J. Antipov (Oakland, California); Shawdee Eshghi (Oakland, California); Kristopher M. Kuchenbecker (Phoenix, Arizona); Bjorn L. Millard (Orinda, California); Matthew D. Onsum (El Cerrito, California); Andrea D. Nickerson (San Francisco, California); Timothy R. Stowe (San Francisco, California); Yan Zhang (San Francisco, California) |
| ABSTRACT | Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/668825 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/47 (20130101) C07K 14/65 (20130101) Original (OR) Class C07K 14/765 (20130101) C07K 2319/035 (20130101) C07K 2319/75 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162290 | Ravetch et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Rockefeller University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jeffrey Ravetch (New York, New York); Falk Nimmerjahn (Erlangen, Germany); Yoshikatsu Kaneko (Niigata City, Japan) |
| ABSTRACT | The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a α 2,6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/535507 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 47/68 (20170801) A61K 2039/505 (20130101) Peptides C07K 16/00 (20130101) Original (OR) Class C07K 16/06 (20130101) C07K 16/18 (20130101) C07K 2317/41 (20130101) C07K 2317/71 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 21/005 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6854 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162291 | HEROLD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | ALBERT EINSTEIN COLLEGE OF MEDICINE (Bronx, New York); DUKE UNIVERSITY (Durham, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Betsy C. HEROLD (Rowayton, Connecticut); Garnett KELSOE (Durham, North Carolina); Masayuki KURAOKA (Durham, North Carolina); Clare BURN (Bronx, New York); William R. Jacobs, Jr. (Bronx, New York) |
| ABSTRACT | Provided are antibodies and antigen-binding fragments which bind to herpes simplex virus-2 (HSV-2), methods of use employing the antibodies and/or antigen-binding fragments, and pharmaceutical compositions comprising the antibodies and/or antigen-binding fragments. |
| FILED | Thursday, March 19, 2020 |
| APPL NO | 17/440452 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/522 (20130101) A61K 39/42 (20130101) Peptides C07K 16/087 (20130101) Original (OR) Class C07K 2317/21 (20130101) C07K 2317/24 (20130101) C07K 2317/732 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162294 | WU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | YALE UNIVERSITY (New Haven, Connecticut) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dianqing WU (Cheshire, Connecticut); Bo CHEN (Daly City, California); Hai WU (Palo Alto, California) |
| ABSTRACT | The present invention relates to the discovery that inhibition of Dickkopf2 (DKK2) increases CD8+ cytotoxic T lymphocyte (CTL) activity, attenuates tumor, and hence suppresses tumor formation. Thus, in various embodiments described herein, the methods of the invention relate to methods of treating cancer by administering to a patient an effective amount of a humanized anti-DKK2 antibody, methods for providing anti-tumor immunity in a subject, methods of stimulating a T cell mediated immune response to a cell population or a tissue and suppressing tumor in a subject. Additionally, the current invention includes methods of diagnosing a cancer or a predisposition of developing a cancer or a metastasis and methods for determining the use of immunotherapy treatment or cancer vaccine for treating cancer. Furthermore, the invention encompasses a pharmaceutical composition for treating cancer as well as a kit for carrying out the aforementioned methods. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/666018 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/001102 (20180801) A61K 39/39558 (20130101) A61K 2039/505 (20130101) A61K 2039/507 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) A61P 35/04 (20180101) Peptides C07K 16/18 (20130101) Original (OR) Class C07K 16/2818 (20130101) C07K 2317/24 (20130101) C07K 2317/34 (20130101) C07K 2317/76 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/68 (20130101) G01N 33/574 (20130101) G01N 2800/52 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162340 | Fedorov et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New Yourk, New York) |
| ASSIGNEE(S) | MEMORIAL SLOAN KETTERING CANCER CENTER (New York, New York) |
| INVENTOR(S) | Victor D. Fedorov (New York, New York); Michel Sadelain (New York, New York) |
| ABSTRACT | The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing an antigen recognizing receptor and an inhibitory chimeric antigen receptor (iCAR). Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired. |
| FILED | Monday, January 24, 2022 |
| APPL NO | 17/583117 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 39/0011 (20130101) A61K 39/00117 (20180801) A61K 39/00118 (20180801) A61K 39/001102 (20180801) A61K 39/001106 (20180801) A61K 39/001109 (20180801) A61K 39/001112 (20180801) A61K 39/001113 (20180801) A61K 39/001114 (20180801) A61K 39/001117 (20180801) A61K 39/001119 (20180801) A61K 39/001124 (20180801) A61K 39/001126 (20180801) A61K 39/001128 (20180801) A61K 39/001129 (20180801) A61K 39/001153 (20180801) A61K 39/001157 (20180801) A61K 39/001166 (20180801) A61K 39/001168 (20180801) A61K 39/001171 (20180801) A61K 39/001182 (20180801) A61K 39/001186 (20180801) A61K 39/001188 (20180801) A61K 39/001193 (20180801) A61K 39/001195 (20180801) A61K 2039/5156 (20130101) A61K 2039/5158 (20130101) Peptides C07K 14/7051 (20130101) C07K 14/70514 (20130101) C07K 14/70517 (20130101) C07K 16/40 (20130101) Original (OR) Class C07K 2317/622 (20130101) C07K 2319/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162398 | Ma et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Peter X. Ma (Ann Arbor, Michigan); Chao Zhao (Tuscaloosa, Alabama); Zhong Wang (Ann Arbor, Michigan) |
| ABSTRACT | A tri-block copolymer includes a first end block consisting of a hydrophobic, nano-fiber forming polymer, wherein the first end block is present in the tri-block copolymer at a weight percentage ranging from about 10% to about 89%; a middle block attached to the first end block, the middle block consisting of a hydrophilic polymer, wherein the middle block is present in the tri-block copolymer at a weight percentage ranging from about 1% to about 89%; and a second end block attached to the middle block, the second end block consisting of a temperature-responsive polymer, wherein the second end block is present in the tri-block copolymer at a weight percentage ranging from about 1% to about 89%. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 17/602678 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/1647 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/16 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 81/027 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162554 | Meissner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Torsten B. Meissner (Cambridge, Massachusetts); Kabungo Y. Mulumba (Cambridge, Massachusetts); Leonardo M.R. Ferreira (Cambridge, Massachusetts); Chad A. Cowan (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are modified primary human T cells and populations thereof comprising a genome in which the CTLA4, PD1, TCRA, TCRB, and/or B2M genes have been edited to generate an off-the-shelf universal CAR T cell from allogeneic healthy donors that can be administered to any patient while reducing or eliminating the risk of immune rejection or graft versus host disease, and which are not prone to T cell inhibition, and methods for allogeneic administration of such cells to reduce the likelihood that the cells will trigger a host immune response when the cells are administered to a subject in need of such cells. |
| FILED | Friday, November 12, 2021 |
| APPL NO | 17/525644 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2039/5156 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/1138 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162555 | Meissner et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | President and Fellows of Harvard College (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Torsten B. Meissner (Cambridge, Massachusetts); Kabungo Y. Mulumba (Cambridge, Massachusetts); Leonardo M.R. Ferreira (Cambridge, Massachusetts); Chad A. Cowan (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are modified primary human T cells and populations thereof comprising a genome in which the CTLA4, PD1, TCRA, TCRB, and/or B2M genes have been edited to generate an off-the-shelf universal CAR T cell from allogeneic healthy donors that can be administered to any patient while reducing or eliminating the risk of immune rejection or graft versus host disease, and which are not prone to T cell inhibition, and methods for allogeneic administration of such cells to reduce the likelihood that the cells will trigger a host immune response when the cells are administered to a subject in need of such cells. |
| FILED | Thursday, December 02, 2021 |
| APPL NO | 17/540968 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) A61K 2039/5158 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0636 (20130101) C12N 5/0638 (20130101) Original (OR) Class C12N 15/85 (20130101) C12N 15/102 (20130101) C12N 15/1138 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162557 | Brown |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Maine Medical Center Research Institute (Scarborough, Maine) |
| ASSIGNEE(S) | Maine Medical Center Research Institute (Scarborough, Maine); Maine Medical Center Research Institute (Scarborough, Maine) |
| INVENTOR(S) | Aaron C. Brown (Portland, Maine) |
| ABSTRACT | Provided herein are, inter alia, methods, compositions, and kits for producing adipocyte populations such as beige adipocyte populations. Also included are methods and compositions for increasing the level of adipocyte populations (e.g., beige adipocyte populations) in a subject, as well as methods and compositions for treating subjects who are overweight, obese, or who have diabetes. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/667934 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/35 (20130101) A61K 38/2026 (20130101) A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 3/04 (20180101) A61P 3/06 (20180101) A61P 3/10 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0653 (20130101) Original (OR) Class C12N 2501/999 (20130101) C12N 2501/2304 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162566 | ROHWER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Forest ROHWER (San Diego, California); Jeremy J. BARR (San Diego, California) |
| ABSTRACT | Provided are compositions and methods for treating, ameliorating and preventing infections, disorders and conditions in mammals, including genetically-predisposed and chronic disorders, where a microbial or bacterial flora is at least one causative or symptom-producing factor. Provided are compositions and methods used to treat, prevent or ameliorate an infection, for example, an infection in the gastrointestinal tract, or bowel. Provided are compositions and methods for treating, ameliorating and/or preventing a condition comprising an abnormal, disrupted or pathological mucosal surface or mucus-covered epithelium, or a condition caused, modified or effected by an abnormal, disrupted or pathological microbiotia, wherein optionally the infection or condition comprises a diarrhea, a colitis, obesity, diabetes, autism, a cystic fibrosis, a dysentery, a gastrointestinal infection, a gastrointestinal inflammation, a gastrointestinal dysbiosis, a gastrointestinal upset, a lung infection, a bacterial infection, a viral infection, a secondary infection, an inflammation, a mucus hypersecretion, or a dysbiosis. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/534372 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/76 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/04 (20180101) Peptides C07K 14/005 (20130101) C07K 2319/035 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) Original (OR) Class C12N 2795/00021 (20130101) C12N 2795/00022 (20130101) C12N 2795/00031 (20130101) C12N 2795/00033 (20130101) Technologies for Adaptation to Climate Change Y02A 50/30 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162579 | VERESS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NATIONAL JEWISH HEALTH (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Livia A. VERESS (Denver, Colorado); Carl W. WHITE (Denver, Colorado) |
| ABSTRACT | The present invention is directed to methods of treatment of airway obstruction associated with fibrin-containing cast formation by administering a fibrinolytic agent. |
| FILED | Monday, December 06, 2021 |
| APPL NO | 17/543407 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0078 (20130101) A61K 38/49 (20130101) A61K 38/482 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/6459 (20130101) Original (OR) Class C12N 9/6462 (20130101) Enzymes C12Y 304/21068 (20130101) C12Y 304/21073 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162583 | Campbell et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Mayo Foundation for Medical Education and Research (Rochester, Minnesota) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jarryd M. Campbell (Rochester, Minnesota); Stephen C. Ekker (Rochester, Minnesota) |
| ABSTRACT | Disclosed is a method for editing mitochondrial DNA (mtDNA) within a cell, which include introducing into the cell (a) a DNA cleaving enzyme targeted to the mtDNA sequence to be deleted; (b) a first DNA binding component targeted to a sequence adjacent to the 5′ end of a mtDNA sequence to be deleted; and (c) a second DNA binding component targeted to a sequence adjacent to the 3′ end of the mtDNA sequence to be deleted, where the DNA cleaving enzyme generates a double stranded break (DSB) within the mtDNA sequence to be deleted or generates a single strand nick on the light strand of the mtDNA sequence to be deleted, and wherein the mtDNA sequence between the target sequence for the first DNA binding component and the target sequence for the second DNA binding component is deleted. |
| FILED | Monday, January 28, 2019 |
| APPL NO | 17/425876 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/102 (20130101) Original (OR) Class Enzymes C12Y 301/21004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162584 | Zhang et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Feng Zhang (Cambridge, Massachusetts); Bernd Zetsche (Cambridge, Massachusetts); Winston YAN (Cambridge, Massachusetts); Neville Espi Sanjana (Cambridge, Massachusetts); Sara Jones (Cambridge, Massachusetts) |
| ABSTRACT | The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. |
| FILED | Monday, February 07, 2022 |
| APPL NO | 17/666248 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 15/63 (20130101) C12N 15/102 (20130101) Original (OR) Class C12N 15/113 (20130101) C12N 15/907 (20130101) C12N 2310/20 (20170501) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162617 | MOOTHA et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | The Broad Institute, Inc. (Cambridge, Massachusetts); The General Hospital Corporation (Boston, Massachusetts) |
| INVENTOR(S) | Vamsi Krishna MOOTHA (Cambridge, Massachusetts); Alexis André JOURDAIN (Cambridge, Massachusetts) |
| ABSTRACT | Described are methods for enhancing exon skipping in a pre-mRNA of interest, comprising contacting the pre-mRNA with interfering oligonucleotides such as antisense, siRNA, and miRNA. The exon skipping methods are associated with methods of treating a variety of diseases and conditions, including cancer. |
| FILED | Wednesday, September 22, 2021 |
| APPL NO | 17/482292 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/7088 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1138 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162618 | DONG et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Ohio State Innovation Foundation (Columbus, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yizhou DONG (Dublin, Ohio); Chunxi ZENG (Dublin, Ohio); Weiyu ZHAO (Columbus, Ohio) |
| ABSTRACT | The present disclosure relates to a series of engineered mRNA sequences and methods of use for improving protein expression. |
| FILED | Wednesday, March 25, 2020 |
| APPL NO | 17/442471 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/215 (20130101) A61K 2039/53 (20130101) Peptides C07K 14/005 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/67 (20130101) Original (OR) Class C12N 2770/20034 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162639 | Lipshutz et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Gerald Lipshutz (Los Angeles, California); Matthew Nitzahn (Los Angeles, California) |
| ABSTRACT | Carbamoyl phosphate synthetase 1 (CPS1) deficiency is a metabolic disorder of the liver that results m abnormal nitrogen metabolism. To illustrate the ability of gene therapy to treat CPS1 deficiency, two adeno-associated viruses encoding portions of a codon optimized CPS1 were generated and tested in a conditional CPS1 knock out mouse model. When administered to mice having knocked out endogenous CPS1 expression, mice from this model demonstrate homologous recombination and reconstitution of the codon optimized CPS1 gene, expression of the CPS1 protein and the associated control of plasma ammonia following the administered AAVs comprising the CPS1 gene sequences. While all control mice perish, the mice in this model live and have normal behavior. As there is no effective therapy for human patients with the CPS1 disorder, this invention can address this unmet need for these patients. |
| FILED | Wednesday, April 15, 2020 |
| APPL NO | 17/601557 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/93 (20130101) C12N 15/86 (20130101) Original (OR) Class C12N 2750/14143 (20130101) C12N 2750/14144 (20130101) C12N 2800/22 (20130101) Enzymes C12Y 603/04016 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162649 | CHOUDHARY et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit CHOUDHARY (Boston, Massachusetts); Donghyun LIM (Boston, Massachusetts); Praveen KOKKONDA (Boston, Massachusetts); Sophia LAI (Boston, Massachusetts); Miseon LEE (Cambridge, Massachusetts) |
| ABSTRACT | The present inventions generally relate to site-specific delivery of nucleic acid modifiers and includes novel DNA-binding proteins and effectors that can be rapidly programmed to make site-specific DNA modifications. The present inventions also provide synthetic all-in-one genome editor (SAGE) systems comprising designer DNA sequence readers and a set of small molecules that induce double-strand breaks, enhance cellular permeability, inhibit NHEJ and activate HDR, as well as methods of using and delivering such systems. |
| FILED | Wednesday, April 01, 2020 |
| APPL NO | 17/601052 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/11 (20130101) C12N 15/62 (20130101) C12N 15/115 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2310/351 (20130101) C12N 2310/3181 (20130101) C12N 2310/3513 (20130101) C12N 2320/32 (20130101) C12N 2330/31 (20130101) C12N 2800/80 (20130101) C12N 2830/001 (20130101) C12N 2840/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162651 | Trego et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Synvitrobio, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelly S. Trego (San Francisco, California); Louis E. Metzger, IV (San Francisco, California); Abel C. Chiao (San Francisco, California); Zachary Z. Sun (San Francisco, California); Dan E. Robertson, IV (San Franciso, California); Benjamin Mohr (San Franciso, California) |
| ABSTRACT | Compositions and methods disclosed herein relate to improved in vitro cell-free systems for various biological reactions. In one aspect, a composition of the present disclosure includes: a cell-free extract derived from an organism; a nucleic acid; and an organelle that is heterologous to the organism. |
| FILED | Monday, March 09, 2020 |
| APPL NO | 17/437288 |
| CURRENT CPC | Peptides C07K 14/43504 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162674 | Blattman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Joseph Blattman (Scottsdale, Arizona); Louis Schoettle (Tempe, Arizona) |
| ABSTRACT | Methods for incorporation of unique bowtie-barcodes into a nucleic acid origami nanostructure (FIG. 1). In particular, provided herein are methods that facilitate pairing and analysis of nucleic acids from individual cells using, for example, high-throughput next-generation sequencing. |
| FILED | Thursday, December 09, 2021 |
| APPL NO | 17/546953 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/87 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6869 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162694 | Drmanac et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Complete Genomics, Inc (San Jose, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Radoje Drmanac (Los Altos Hills, California); Matthew J. Callow (Mountain View, California); Snezana Drmanac (Los Altos Hills, California); Brian K. Hauser (Campbell, California); George Yeung (Mountain View, California) |
| ABSTRACT | Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. |
| FILED | Tuesday, November 09, 2021 |
| APPL NO | 17/522708 |
| CURRENT CPC | Sugars; Derivatives Thereof; Nucleosides; Nucleotides; Nucleic Acids C07H 21/04 (20130101) Peptides C07K 1/047 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/682 (20130101) C12Q 1/6806 (20130101) C12Q 1/6837 (20130101) C12Q 1/6869 (20130101) C12Q 1/6874 (20130101) Original (OR) Class C12Q 2525/151 (20130101) C12Q 2525/313 (20130101) C12Q 2531/125 (20130101) C12Q 2565/513 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1404 (20130101) G01N 15/1434 (20130101) Technical Subjects Covered by Former USPC Cross-reference Art Collections [XRACs] and Digests Y10S 977/88 (20130101) Y10S 977/778 (20130101) Y10S 977/789 (20130101) Y10S 977/792 (20130101) Y10S 977/882 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162701 | O'Bryant et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of North Texas Health Science Center at Fort Worth (Fort Worth, Texas); Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sid E. O'Bryant (Aledo, Texas); Robert C. Barber (Benbrook, Texas); Guanghua Xiao (Coppell, Texas); Dwight German (Dallas, Texas) |
| ABSTRACT | The present invention includes methods and kits for measuring a level of four or more biomarkers selected from IL1, IL7, TNFα, IL5, IL6, CRP, IL10, TNC, ICAM1, FVII, I309, TNFR1, A2M, TARC, adiponectin, MIP1, eotaxin3, sVCAM1, TPO, FABP, IL18, B2M, SAA, PPY, DJ1, α-synuclein, Ab40, Ab42, tau, alpha-syn, and NfL in a sample separated from a human subject in the primary care setting with neurological disease with a nucleic acid, an immunoassay or an enzymatic activity assay. |
| FILED | Friday, February 14, 2020 |
| APPL NO | 17/430748 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/158 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/00 (20190201) G16B 40/20 (20190201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162703 | GONSKY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | CEDARS-SINAI MEDICAL CENTER (Los Angeles, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Rebecca GONSKY (Los Angeles, California); Stephan R. TARGAN (Santa Monica, California); Richard L. DEEM (Azusa, California); Philip FLESHNER (Los Angeles, California); Dermot P. MCGOVERN (Los Angeles, California); Janine BILSBOROUGH (Los Angeles, California) |
| ABSTRACT | The present invention describes methods of diagnosing inflammatory bowel disease, including but not limited to Crohn's Disease (CD), Ulcerative Colitis (UC), and/or Medically Refractive Ulcerative Colitis (MR-UC), using RNASET2, TL1A and/or IFN-γ. The invention further provides a process for patient identification and/or stratification. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513693 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/686 (20130101) C12Q 1/6806 (20130101) C12Q 1/6834 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 2600/106 (20130101) C12Q 2600/154 (20130101) C12Q 2600/156 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 2800/065 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162704 | BREAKEFIELD et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The General Hospital Corporation (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Xandra O. BREAKEFIELD (Newton, Massachusetts); Johan Karl Olov SKOG (New York, New York); Dennis BROWN (Natick, Massachusetts); Kevin C. MIRANDA (St. Louis, Missouri); Leileata M. RUSSO (Cambridge, Massachusetts) |
| ABSTRACT | Methods for preparing microRNAs from microvesicles isolated from a biological sample from a subject, and preparation of DNA from microvesicle microRNA preparations. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667132 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1017 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) C12Q 1/6883 (20130101) Original (OR) Class C12Q 1/6886 (20130101) C12Q 2600/106 (20130101) C12Q 2600/112 (20130101) C12Q 2600/156 (20130101) C12Q 2600/158 (20130101) C12Q 2600/178 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163468 | YU et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Yihua Bruce YU (Ellicott City, Maryland); Marc B. TARABAN (North Potomac, Maryland); Katharine T. BRIGGS (Germantown, Maryland) |
| ASSIGNEE(S) | University of Maryland, Baltimore (Baltimore, Maryland) |
| INVENTOR(S) | Yihua Bruce YU (Ellicott City, Maryland); Marc B. TARABAN (North Potomac, Maryland); Katharine T. BRIGGS (Germantown, Maryland) |
| ABSTRACT | A method of using the relaxation rate (R1 and/or R2) of solvent NMR signal to invasively or noninvasively assess whether vaccines and other aqueous-based pharmaceutical products have been frozen during transport and/or storage. |
| FILED | Wednesday, March 11, 2020 |
| APPL NO | 17/436169 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 24/08 (20130101) Original (OR) Class G01N 33/15 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163511 | CHOI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island); Rhode Island Hospital (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bum-Rak CHOI (Warwick, Rhode Island); Kareen L. K. COULOMBE (Pawtucket, Rhode Island) |
| ABSTRACT | The Cardiac Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels. |
| FILED | Friday, October 15, 2021 |
| APPL NO | 17/502800 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5014 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163513 | Fowler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Douglas Fowler (Seattle, Washington); Nicholas Hasle (Seattle, Washington); Sriram Pendyala (Seattle, Washington); Hyeon-Jin Kim (Seattle, Washington) |
| ABSTRACT | The disclosure provides methods, systems and related software, for automated or semi-automated sorting and/or isolating cells with visually distinguishable phenotypes. In some embodiments, the methods comprise providing a plurality cells with a photo-activatable detectable marker in their respective nuclei. The plurality of cells are imaged and, based on the image, the status for one or more visually identifiable phenotypes are determined. Cells determined to have the desired phenotype status are specifically exposed to a light wavelength for a time sufficient to uniquely activate the photo-activatable detectable marker in the individual cells with the desired phenotype status. The cells are then sorted on the basis of the activated detectable marker. The disclosure also provides methods for preparation and isolation of nuclei from fixed, adherent cells for analysis. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532917 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 15/1056 (20130101) G01N 33/582 (20130101) G01N 33/5026 (20130101) Original (OR) Class G01N 2015/1006 (20130101) G01N 2015/1081 (20130101) Optical Elements, Systems, or Apparatus G02B 21/26 (20130101) G02B 21/365 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 7/70 (20170101) G06T 2207/10056 (20130101) G06T 2207/30024 (20130101) G06T 2207/30204 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163515 | Boyden et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Edward S. Boyden (Cambridge, Massachusetts); Katarzyna P. Adamala (Cambridge, Massachusetts); Daniel Alberto Martin-Alarcon (Cambridge, Massachusetts) |
| ABSTRACT | A programmable modular protein architecture for RNA binding comprises a set of modules, derived from RNA-binding protein Pumilio, that can be concatenated into chains of varying composition and length. When bound into a chain, each module has a preferred affinity for a specific RNA base. The chains can bind arbitrary RNA sequences with high specificity and fidelity by varying the sequence of modules within the chains. Each module contains at least 6 amino acids, with the amino acids in positions 1 and 5 providing the preferred affinity for the specific base, and the amino acid at position 2 serving as a stacking unit between concatenated modules. The modules may have four canonic forms, each having a preferred affinity for a different base and characterized by the base with which it has affinity, the two amino acids that provide the affinity, and the amino acid that serves as a stacking unit. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/667610 |
| CURRENT CPC | Peptides C07K 14/47 (20130101) Combinatorial Chemistry; Libraries, e.g Chemical Libraries C40B 40/10 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/5308 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163519 | Tseng et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Hsian-Rong Tseng (Los Angeles, California); Yazhen Zhu (Los Angeles, California); Jiantong Dong (Los Angeles, California) |
| ABSTRACT | Methods and kits for capturing extracellular vesicles from a fluid sample, including: providing a microfluidic chip having a device for capturing extracellular vesicles from the fluid sample; flowing the fluid sample through a fluid channel defined by a channel-defining layer in the microfluidic chip so as to capture extracellular vesicles from the fluid sample; removing a membrane from the device for capturing extracellular vesicles after providing the fluid sample; and collecting the extracellular vesicles captured from the fluid sample. |
| FILED | Thursday, March 19, 2020 |
| APPL NO | 17/440653 |
| CURRENT CPC | Chemical or Physical Laboratory Apparatus for General Use B01L 3/502761 (20130101) B01L 2200/16 (20130101) B01L 2200/0652 (20130101) B01L 2300/08 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/54366 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163531 | Katchman et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (Scottsdale, Arizona); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Benjamin Katchman (Tempe, Arizona); Karen Anderson (Scottsdale, Arizona); Garrick Wallstrom (Mesa, Arizona); Joshua LaBaer (Chandler, Arizona); Daniel Cramer (Chestnut Hill, Massachusetts) |
| ABSTRACT | Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3. |
| FILED | Tuesday, December 28, 2021 |
| APPL NO | 17/563279 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57449 (20130101) Original (OR) Class G01N 2800/60 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163532 | SOOD et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Anil K. SOOD (Houston, Texas); Akira YOKOI (Houston, Texas) |
| ABSTRACT | The present invention provides that exosomes from ovarian cancer patients contain nuclear proteins and genomic DNA at an increased proportion. As such, detecting nuclear-derived exosomes provides a method of early detection of ovarian cancer. Furthermore, the level of nuclear-derived exosomes can be monitored over time to assess responsiveness to genotoxic therapy. |
| FILED | Friday, March 27, 2020 |
| APPL NO | 17/598780 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/57449 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163536 | MARCOTTE et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edward MARCOTTE (Austin, Texas); Jagannath SWAMINATHAN (Austin, Texas); Andrew ELLINGTON (Austin, Texas); Eric ANSLYN (Austin, Texas) |
| ABSTRACT | The present invention relates to methods for identifying amino acids in peptides. In one embodiment, the present invention contemplates labeling the N-terminal amino acid with a first label and labeling an internal amino acid with a second label. In some embodiments, the labels are fluorescent labels. In other embodiments, the internal amino acid is lysine. In other embodiments, amino acids in peptides are identified based on the fluorescent signature for each peptide at the single molecule level. |
| FILED | Friday, July 23, 2021 |
| APPL NO | 17/384118 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6824 (20130101) Original (OR) Class G01N 2570/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163540 | Hazen et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Cleveland Clinic Foundation (Cleveland, Ohio) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stanley L. Hazen (Pepper Pike, Ohio); Zeneng Wang (Shaker Heights, Ohio) |
| ABSTRACT | The present invention relates to methods, kits, and compositions for: i) detecting the level of 3-bromotyrosine in a sample that has been treated to liberate 3-bromotyrosine from 4-O-glucuronide-3-bromotyrosine, and/or ii) detecting the level of 4-O-glucuronide-3-bromotyrosine, and/or the combined level of both 4-O-glucuronide-3-bromotyrosine and 3-bromotyrosine, in a sample that has not been treated to liberate 3-bromotyrosine from 4-O-glucuronide-3-bromotyrosine. In certain embodiments, such detected levels are used to: i) identify the presence, severity, or risk of an eosinophilic disorder (e.g., asthma or a TH2-high eosinophilic disorder); ii) identify therapy effective for treating asthma or an eosinophilic disorder; or iii) identify patients suitable for treatment with therapeutic agents targeted to asthma or an eosinophilic disorder. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/668261 |
| CURRENT CPC | Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/6893 (20130101) Original (OR) Class G01N 2800/52 (20130101) G01N 2800/122 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163541 | ALEXANDER et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| ASSIGNEE(S) | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (Baton Rouge, Louisiana) |
| INVENTOR(S) | Johnathan Steven ALEXANDER (Shreveport, Louisiana); Christopher KEVIL (Shreveport, Louisiana); Elizabeth DISBROW (Shreveport, Louisiana); Karen Y. STOKES (Shreveport, Louisiana); J. Winny YUN (Shreveport, Louisiana); Pooja VEERAREDDY (Shreveport, Louisiana); Urska Cvek (Shreveport, Louisiana) |
| ABSTRACT | The presently disclosed invention relates to a method of diagnosing Multiple Sclerosis (MS) in a patient comprising obtaining a sample from the patient, determining a level of one or more H2S generating enzymes in the sample from the patient, and diagnosing the patient with MS when the level of the one or more H2S generating enzymes is one of at least 15% higher or lower than a control level for the one or more H2S generating enzymes, and at least 10% higher or lower than a control level for the one or more H2S generating enzymes. |
| FILED | Friday, November 26, 2021 |
| APPL NO | 17/535982 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/13 (20130101) C12N 9/88 (20130101) C12N 9/1085 (20130101) Enzymes C12Y 205/01 (20130101) C12Y 208/01002 (20130101) C12Y 404/01001 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/573 (20130101) G01N 33/6896 (20130101) Original (OR) Class G01N 2800/285 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220164126 | Gundlach et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | University of Washington (Seattle, Washington) |
| ASSIGNEE(S) | University of Washington (Seattle, Washington) |
| INVENTOR(S) | Jens H. Gundlach (Seattle, Washington); Ian M. Derrington (Seattle, Washington); Marcus D. Collins (Issaquah, Washington) |
| ABSTRACT | Provided herein are methods and systems pertaining to sequencing units of analytes using nanopores. In general, arresting constructs are used to modify an analyte such that the modified analyte pauses in the opening of a nanopore. During such a pause, an ion current level is obtained that corresponds to a unit of the analyte. After altering the modified analyte such that the modified analyte advances through the opening, another arresting construct again pauses the analyte, allowing for a second ion current level to be obtained that represents a second unit of the analyte. This process may be repeated until each unit of the analyte is sequenced. Systems for performing such methods are also disclosed. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/534869 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/206 (20130101) G06F 3/061 (20130101) G06F 3/0604 (20130101) G06F 3/0614 (20130101) G06F 3/0616 (20130101) G06F 3/0625 (20130101) G06F 3/0629 (20130101) G06F 3/0647 (20130101) G06F 3/0653 (20130101) Original (OR) Class G06F 3/0659 (20130101) G06F 3/0673 (20130101) G06F 3/0679 (20130101) G06F 12/0238 (20130101) G06F 12/0246 (20130101) Static Stores G11C 7/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220165363 | Yeh et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| ASSIGNEE(S) | The University of North Carolina at Chapel Hill (Chapel Hill, North Carolina) |
| INVENTOR(S) | Jen Jen Yeh (Chapel Hill, North Carolina); Xianlu (Laura) Peng (Chapel Hill, North Carolina) |
| ABSTRACT | Provided are methods for de novo deconvoluting of datasets with multiple samples and/or estimating compartment weights for single samples. In some embodiments, the methods include applying the process or processes to a dataset with multiple samples or to a single sample, whereby the dataset is deconvoluted and/or a compartment weight is estimated. In some embodiments, the dataset relates to RNA sequence and/or gene expression data, optionally tumor RNA sequence and/or gene expression data, wherein the tumor is in some embodiments a pancreatic tumor, a prostate cancer, a bladder cancer, or a breast cancer. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/441138 |
| CURRENT CPC | Electric Digital Data Processing G06F 17/16 (20130101) Bioinformatics, i.e Information and Communication Technology [ICT] Specially Adapted for Genetic or Protein-related Data Processing in Computational Molecular Biology G16B 20/20 (20190201) G16B 40/30 (20190201) Original (OR) Class Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 50/20 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Defense (DOD)
| US 20220160257 | THOMPSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Kyle THOMPSON (Boulder, Colorado); Gary A. SHAW (Westford, Massachusetts); Andrew M. SIEGEL (Arlington, Massachusetts); Lawrence M. CANDELL (Arlington, Massachusetts) |
| ABSTRACT | A fluid dynamic valve passively allows fluid flow out of a moving stream in one flow direction and not in the reverse. This allows the collection of fluid from a single direction of an AC fluid flow. The siphoned portion of the flow has a flow rate proportional to the mainstream flow. This device can collect exhaled breath or selective entrenchment during inhale. In one orientation, it can meter aerosolized particles into an inhale breath stream for pulmonary delivery, without complicated breath timing or drug loss due to drug adsorption to the back of the throat. Alternatively, a user can breathe through the device and a proportional amount, relative to the volumetric flow rate, of each exhale can flow into an auxiliary chamber for analysis. In addition, the device has a low respiratory burden and is comfortable to use. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/537204 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/082 (20130101) A61B 5/097 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160522 | Herr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Hugh M. Herr (Concord, New Hampshire); Matthew Lawrence Handford (Cambridge, Massachusetts); Christopher Charles Williams (Pittsburgh, Pennsylvania); Matthew Eli Carney (Medford, Massachusetts); Daniel Visan Levine (Decatur, Georgia) |
| ABSTRACT | An ankle-foot prosthesis comprises a foot structure having a foot keel leaf spring, a heel leaf spring, and an upper J leaf spring above the keel leaf spring. An ankle bearing block is mounted to the keel leaf spring and a shank shell is mounted to the ankle bearing block. A shank interface mounts to the shank shell. A processor controlled active element extends along an axis between the shank shell and the upper leaf-spring. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/455884 |
| CURRENT CPC | Filters Implantable into Blood Vessels; Prostheses; Devices Providing Patency To, or Preventing Collapsing Of, Tubular Structures of the Body, e.g Stents; Orthopaedic, Nursing or Contraceptive Devices; Fomentation; Treatment or Protection of Eyes or Ears; Bandages, Dressings or Absorbent Pads; First-aid Kits A61F 2/68 (20130101) A61F 2/6607 (20130101) Original (OR) Class A61F 2002/5003 (20130101) A61F 2002/6664 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160631 | Shukla et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anita Shukla (Providence, Rhode Island); Sarah Cowles (Bedford, Massachusetts); Noel Vera-Gonzalez (San Juan, Puerto Rico); Christina Bailey-Hytholt (Millbury, Massachusetts); Eli Silvert (Woodbridge, Connecticut) |
| ABSTRACT | The invention provides functionalized antifungal-loaded liposomal formulations targeting Candida, which minimize damage to healthy human cells, limit antimicrobial exposure, and reduce the development of antifungal resistance. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589554 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class A61K 38/12 (20130101) A61K 47/14 (20130101) A61K 47/42 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160678 | LI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Rong LI (Washington, District of Columbia); Bin YUAN (Hefei City, China PRC); Kate Ida LATHROP (San Antonio, Texas) |
| ABSTRACT | The present invention provides methods and compositions for modulating molecular markers, and hence treating or preventing breast cancer (e.g., triple-negative breast cancer) and melanoma with a pharmaceutically effective amount of S-equol or a pharmaceutical composition comprising S-equol. The S-equol may be administered alone or in combination with one or more cytotoxic or immunotherapeutic compound or molecule. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/535125 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/353 (20130101) Original (OR) Class A61K 39/39541 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160772 | O'Malley et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/650640 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160773 | O'Malley et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Baylor College of Medicine (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Bert W. O'Malley (Houston, Texas); Sang Jun Han (Houston, Texas); David M. Lonard (Houston, Texas); Bryan Nikolai (Houston, Texas); Prashi Jain (Houston, Texas); Yosef Gilad (Houston, Texas); Clifford Dacso (Houston, Texas) |
| ABSTRACT | The present disclosure concerns methods and compositions related to cancer treatment comprising targeting of SRC-3 in immune cells, including T cells such as T regulatory cells. The targeting of SRC-3 in T regulatory cells in particular is effective to eradicate tumors in mammals. In specific cases, the T regulatory cells are subjected to CRISPR ex vivo to produce cells suitable for adoptive cell transfer. In some cases, one or more agents that target SRC-3 are also administered to the individual and/or are exposed to the cells prior to administration. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/650645 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 35/17 (20130101) Original (OR) Class A61K 45/06 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 5/0637 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160813 | Davisson et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| ASSIGNEE(S) | Purdue Research Foundation (West Lafayette, Indiana) |
| INVENTOR(S) | Vincent Jo Davisson (West Lafayette, Indiana); Matthew David Bartolowits (West Lafayette, Indiana); Jonathon Michael Gast (Lafayette, Indiana) |
| ABSTRACT | The present invention relates to series of compounds as an inhibitor targeting Proliferating Cell Nuclear Antigen (PCNA). Pharmaceutical compositions of those compounds and methods of using them in the treatment of cancer are within the scope of this disclosure. |
| FILED | Wednesday, August 12, 2020 |
| APPL NO | 16/991534 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) A61K 38/06 (20130101) Original (OR) Class A61K 45/06 (20130101) Peptides C07K 5/08 (20130101) C07K 5/0806 (20130101) C07K 5/0812 (20130101) C07K 5/06086 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160855 | Dutta et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| ASSIGNEE(S) | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (Bethesda, Maryland) |
| INVENTOR(S) | Sheetij Dutta (Silver Spring, Maryland); Zoltan Beck (Rockville, Maryland); Carl Alving (Bethesda, Maryland); Gary Matyas (Olney, Maryland) |
| ABSTRACT | The invention relates to pharmaceutical compositions comprising at least one antigen and an adjuvant composition, where the adjuvant composition comprises a saponin and a liposome. The liposome of the composition comprises monophosphoryl lipid A (MPLA), cholesterol and a phospholipid that is in a liquid crystalline state at greater than or equal to 23° C., and the concentration of cholesterol to lipid in the liposome is greater than 50% (mol/mol). The antigen in the composition is a soluble Plasmodium falciparum recombinant circumsporozoite protein (rCSP) comprising the amino acid sequence of SEQ ID NO:1, or a P. falciparum rCSP peptide that is at least 95% identical to the amino acid sequence of SEQ ID NO:1. |
| FILED | Friday, April 27, 2018 |
| APPL NO | 16/607917 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 39/015 (20130101) Original (OR) Class A61K 39/39 (20130101) A61K 2039/55577 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160891 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan J. Green (Baltimore, Maryland); Stephany Yi Tzeng (Baltimore, Maryland); Kelly Rhodes (Baltimore, Maryland); Giorgio Raimondi (Baltimore, Maryland); Marcos Iglesias (Baltimore, Maryland); Jamie Spangler (Baltimore, Maryland); Jakub Tomala (Baltimore, Maryland); Derek VanDyke (Baltimore, Maryland); Randall A. Meyer (Baltimore, Maryland) |
| ABSTRACT | The disclosure is directed to a biodegradable particle comprising a polyester or polyester blend, a first protein that binds to an immune cell, and a second protein that promotes proliferation and/or activation of immune cells, and a third soluble protein or small molecule encapsulated within the particle. The second protein is a fusion protein comprising at least a portion of an antibody and at least a portion of a cytokine (i.e., an immunocytokine). The disclosure also is directed to methods for treating a disease or condition in a subject (e.g., an autoimmune disease) comprising administering the aforementioned biodegradable particle to the subject. |
| FILED | Monday, April 13, 2020 |
| APPL NO | 17/602856 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5031 (20130101) A61K 31/436 (20130101) A61K 47/62 (20170801) A61K 47/6813 (20170801) A61K 47/6845 (20170801) A61K 47/6849 (20170801) A61K 47/6937 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161042 | Lu |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Daniel C. Lu (Los Angeles, California) |
| ABSTRACT | In various embodiments methods and devices are provided for facilitating locomotor function and/or voiding of bladder and/or bowel in a subject with a neuromotor disorder. In certain embodiments the methods involve providing magnetic stimulation of the spinal cord at a location, frequency and intensity sufficient to facilitate locomotor function and/or voiding of bladder and/or bowel. |
| FILED | Tuesday, July 20, 2021 |
| APPL NO | 17/381156 |
| CURRENT CPC | Electrotherapy; Magnetotherapy; Radiation Therapy; Ultrasound Therapy A61N 1/0456 (20130101) A61N 1/36017 (20130101) A61N 1/36034 (20170801) A61N 2/02 (20130101) A61N 2/004 (20130101) A61N 2/006 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161365 | TSUBAKI et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | NUtech Ventures (Lincoln, Nebraska) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alfred T. TSUBAKI (Lincoln, Nebraska); Dennis R. ALEXANDER (Lincoln, Nebraska); Craig ZUHLKE (Lincoln, Nebraska); Jeffrey SHIELD (Lincoln, Nebraska); Mark ANDERSON (Lincoln, Nebraska); Andrew REICKS (Lincoln, Nebraska) |
| ABSTRACT | Aspects and embodiments disclosed herein include a method for forming a plurality of microfeatures, the method comprising: irradiating a starting multi-layer material with a pulsed laser beam at a plurality of locations of the multi-layer material; wherein: the starting multi-layer material comprises a plurality of starting layers comprising a first starting layer having a first composition and a second starting layer adjacent to the first starting layer and having a second composition different than the first composition; the plurality of microfeatures form in the multi-layer starting material during the step of irradiating; each microfeature comprises a plurality of microfeature layers comprising a first microfeature layer having the first composition and a second microfeature layer having the second composition. Optionally, each of the first and second composition is an inorganic material. |
| FILED | Friday, May 28, 2021 |
| APPL NO | 17/333885 |
| CURRENT CPC | Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/362 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161875 | APOSTOLOPOULOS et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | CARNEGIE MELLON UNIVERSITY (Pittsburgh, Pennsylvania) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Dimitrios APOSTOLOPOULOS (Pittsburgh, Pennsylvania); Karl MUECKE (Pittsburgh, Pennsylvania); Nishant POL (Pittsburgh, Pennsylvania); Edward MUTSCHLER (Pittsburgh, Pennsylvania); Matthew GLISSON (Pittsburgh, Pennsylvania); Richard PANTALEO (Pittsburgh, Pennsylvania); Stephen NOVICK (Pittsburgh, Pennsylvania) |
| ABSTRACT | The Reconfigurable Wheel-Track (RWT) is a novel mechanism that allows a wheel to transform into a track, and vice-versa. The wheel permits a vehicle to travel quickly over smooth and semi-rough terrain, then, on-the-fly, transform rapidly into a powered track for crossing extreme terrain. The reconfigurable wheel-track consists of several main components: an outer tire/tread, drive mechanisms for the wheel and track, support mechanisms for the outer tread when in either wheel mode or track mode, and a reconfiguration mechanism that facilitates the transformation from a wheel to a track and vice-versa. The reconfigurable wheel-track includes sensing, actuation, and controls to facilitate efficient and effective transition from wheel to track and vice-versa, and securely maintain each shape. |
| FILED | Wednesday, April 29, 2020 |
| APPL NO | 17/433627 |
| CURRENT CPC | Vehicle Wheels; Castors; Axles for Wheels or Castors; Increasing Wheel Adhesion B60B 19/00 (20130101) B60B 2900/351 (20130101) Motor Vehicles; Trailers B62D 55/04 (20130101) Original (OR) Class B62D 55/15 (20130101) B62D 55/24 (20130101) B62D 55/30 (20130101) B62D 55/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162057 | BLANKENSHIP |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UNITED STATES GOVERNMENT AS REPRESENTED BY THE SECRETARY OF THE ARMY (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | CLINTON BLANKENSHIP (REDSTONE ARSENAL, Alabama) |
| ABSTRACT | The present disclosure provides a microelectronic isolation system comprising a base, vibration isolator, primary sensor, and microprocessor. The base supports the vibration isolator, the primary sensor, and the microprocessor. The vibration isolator has a platform, isolation material, and at least one isolation sensor. The isolation material dampens an overall vibrational frequency experienced by the microelectronic isolation system. The isolation sensor measures a displacement. The displacement is a measurement of a displacement of the platform with respect to the base. The primary sensor measures a primary sensor response, which is received by the microprocessor to calculate a plurality of responses. The plurality of responses of the microprocessor being one or a combination of a measured compensation response, an inertial response, and a restored primary sensor response. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/101732 |
| CURRENT CPC | Microstructural Devices or Systems, e.g Micromechanical Devices B81B 7/0058 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162090 | Ly et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States of America as Represented by The Secretary of The Army (Alexandria, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tung N. Ly (Lorton, Virginia); Donald M. Cropek (Champaign, Illinois); Michael J. Anderson (Detroit, Michigan) |
| ABSTRACT | In one embodiment, a differential water data analysis system includes a data storage, a user interface, and a processor coupled to the data storage and programmed with software to: receive inflow water measurement data from a water inflow line entering a water treatment system and outflow water measurement data from a water outflow line exiting the water treatment system, the inflow water measurement data and outflow water measurement data being obtained by measuring the water in the water inflow line and the water outflow line at about the same time and being received in real time; compare the inflow water measurement data and the outflow water measurement data; compute a performance of the water treatment system based on the comparison using a computation scheme; determine whether the performance is within specification of the water treatment system to produce a determination output; and display the determination output in the user interface. |
| FILED | Monday, November 23, 2020 |
| APPL NO | 17/102007 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/008 (20130101) Original (OR) Class C02F 1/441 (20130101) C02F 2209/02 (20130101) C02F 2209/04 (20130101) C02F 2209/05 (20130101) C02F 2209/006 (20130101) C02F 2209/06 (20130101) C02F 2209/008 (20130101) C02F 2209/11 (20130101) C02F 2209/22 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 33/18 (20130101) Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 19/0423 (20130101) G05B 2219/25252 (20130101) G05B 2219/25257 (20130101) Data Processing Systems or Methods, Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes; Systems or Methods Specially Adapted for Administrative, Commercial, Financial, Managerial, Supervisory or Forecasting Purposes, Not Otherwise Provided for G06Q 10/06395 (20130101) G06Q 50/26 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162649 | CHOUDHARY et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE BROAD INSTITUTE, INC. (Cambridge, Massachusetts); THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Amit CHOUDHARY (Boston, Massachusetts); Donghyun LIM (Boston, Massachusetts); Praveen KOKKONDA (Boston, Massachusetts); Sophia LAI (Boston, Massachusetts); Miseon LEE (Cambridge, Massachusetts) |
| ABSTRACT | The present inventions generally relate to site-specific delivery of nucleic acid modifiers and includes novel DNA-binding proteins and effectors that can be rapidly programmed to make site-specific DNA modifications. The present inventions also provide synthetic all-in-one genome editor (SAGE) systems comprising designer DNA sequence readers and a set of small molecules that induce double-strand breaks, enhance cellular permeability, inhibit NHEJ and activate HDR, as well as methods of using and delivering such systems. |
| FILED | Wednesday, April 01, 2020 |
| APPL NO | 17/601052 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/22 (20130101) C12N 9/96 (20130101) C12N 15/11 (20130101) C12N 15/62 (20130101) C12N 15/115 (20130101) C12N 15/907 (20130101) Original (OR) Class C12N 2310/16 (20130101) C12N 2310/351 (20130101) C12N 2310/3181 (20130101) C12N 2310/3513 (20130101) C12N 2320/32 (20130101) C12N 2330/31 (20130101) C12N 2800/80 (20130101) C12N 2830/001 (20130101) C12N 2840/002 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162655 | Siddiqui et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Zymergen Inc. (Emeryville, California) |
| ASSIGNEE(S) | Zymergen Inc. (Emeryville, California) |
| INVENTOR(S) | Michael Shareef Siddiqui (Oakland, California); Alexander Glennon Shearer (San Francisco, California); Franklin Lu (Emeryville, California); Stefan de Kok (Emeryville, California); Cara Ann Tracewell (Walnut Creek, California); Steven M. Edgar (Albany, California); Jennifer Yip (Emeryville, California) |
| ABSTRACT | The present disclosure describes the engineering of microbial cells for fermentative production of L-homocysteine and provides novel engineered microbial cells and cultures, as well as related L-homocysteine production methods. |
| FILED | Tuesday, March 24, 2020 |
| APPL NO | 17/442090 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 9/0051 (20130101) C12N 9/1241 (20130101) C12N 15/77 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 13/12 (20130101) Original (OR) Class Enzymes C12Y 108/01002 (20130101) C12Y 108/02001 (20130101) C12Y 108/04008 (20130101) C12Y 207/07004 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162992 | Pal |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Debabrata Pal (Hoffman Estates, Illinois) |
| ABSTRACT | Provided are embodiments for a feeder cooling tube, a system and method for performing thermal management. Embodiments include a feeder cooling tube having an inner tube arranged to define a path to flow a fluid through a length of the inner tube, wherein the fluid is provided to remove heat, and an outer tube arranged to enclose the inner tube which defines an area. Embodiments also include one or more feeder cables arranged between the inner tube and the outer tube, and a plurality of cooling struts, wherein each cooling strut of the plurality of cooling struts extends from a surface of the inner tube to a surface of the outer tube. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/102771 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/14 (20130101) Original (OR) Class F02C 7/16 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2210/11 (20130101) F05D 2260/98 (20130101) F05D 2260/213 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 7/423 (20130101) Dynamo-electric Machines H02K 9/19 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163295 | Gallimore et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Harkind Dynamics, LLC (Denver, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Craig Allen Gallimore (Denver, Colorado); Kelley Stewart Weiland (Fredericksburg, Virginia) |
| ABSTRACT | A small arms form factor munition may package a control section with a deployment section in a munition case. The control section can have a first drag mechanism and a second drag mechanism. Firing the munition case from a firearm propels the load from the munition case and barrel of the firearm towards a target. A drag mechanism is selected and activated by the control section in response to a detected distance to the target while the load is in flight. The drag mechanism alters a flight characteristic of the load. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667171 |
| CURRENT CPC | Armour; Armoured Turrets; Armoured or Armed Vehicles; Means of Attack or Defence, e.g Camouflage, in General F41H 13/0031 (20130101) Original (OR) Class Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 7/02 (20130101) F42B 10/56 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163305 | Graham |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Simmonds Precision Products, Inc. (Vergennes, Vermont) |
| ASSIGNEE(S) | Simmonds Precision Products, Inc. (Vergennes, Vermont) |
| INVENTOR(S) | Jason Graham (Prior Lake, Minnesota) |
| ABSTRACT | A system includes a guided munition having a housing. A first reservoir is defined within the housing holding a first chemical reactant. A second reservoir is defined within the housing, wherein the second reservoir holds a second chemical reactant configured to undergo an endothermic reaction with the first chemical reactant. A frangible barrier separates between the first and second reservoirs. The frangible barrier is configured to break under forces acting on the guided munition as the guided munition is fired from a weapon. An electronic device can be housed within the housing in thermal contact with at least one of the first reservoir and/or second reservoir for cooling the electronic device with an endothermic reaction upon mixing of the first and second chemical reactants. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/104222 |
| CURRENT CPC | Refrigerators; Cold Rooms; Ice-boxes; Cooling or Freezing Apparatus Not Otherwise Provided for F25D 5/00 (20130101) Explosive Charges, e.g for Blasting, Fireworks, Ammunition F42B 15/34 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163307 | Mullin et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| INVENTOR(S) | Edward J. Mullin (Nashua, New Hampshire); Jonathan C. Wellman (Brookline, New Hampshire) |
| ABSTRACT | A mechanical thermal battery initiator for a round where the initiator has a firing pin positioned to strike a primer of a thermal battery upon activation. After installation of the initiator/battery assembly in a round, the end user need not perform any further tasks until firing the munition. At launch, any safety device installed to prevent unintended activation is removed or switched to an active state. When launched, the initiator is subjected to centripetal force and acceleration causing a setback ring to release ball bearings and a spring force from a firing pin spring to push a firing pin into contact with a primer to initiate power on the round. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 16/953436 |
| CURRENT CPC | Ammunition Fuzes; Arming or Safety Means Therefor F42C 15/26 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163389 | Marandi et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Alireza Marandi (Pasadena, California); Mingchen Liu (Pasadena, California); Arkadev Roy (Pasadena, California) |
| ABSTRACT | A system for performing spectroscopy, including a first frequency comb source outputting first electromagnetic radiation comprising a first frequency comb centered at a first wavelength and having a first repetition rate; a second frequency comb source outputting a second electromagnetic radiation comprising a second frequency comb centered at a second wavelength and having a second repetition rate; a nonlinear device positioned to receive the first frequency comb and the second frequency comb, wherein the nonlinear device interacts the first frequency comb and the second frequency comb through sum frequency generation or difference frequency generation so as to generate an output electromagnetic radiation; and a detection system outputting a signal in response to detecting an interference of the output electromagnetic radiation with a third electromagnetic radiation, the signal comprising information used for determining a spectrum of at least the first frequency comb or the second frequency comb. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533926 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/027 (20130101) G01J 3/0275 (20130101) G01J 3/4338 (20130101) Original (OR) Class G01J 2003/4332 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163413 | Nguyen et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Clark T.-C. Nguyen (Oakland, California); Alper Ozgurluk (Berkeley, California) |
| ABSTRACT | An on-chip strain measurement device that uses precision frequency measurements to precisely extract sub-nm displacements, allowing residual strain measurements in a given structural film. Strain-induced gap changes to resonance frequencies use differential strategies to remove bias uncertainty, allowing measurement of sub-nm displacements. Gap-dependent electrical stiffness is used to shift resonance frequencies as structural elements stretch or shrink to relieve strain. An output based on differential frequencies between two proximal structures with unequal stress arm lengths removes uncertainty on the initial gap spacing. The ability to precisely measure the frequency of the high-Q structures allows lifetime stress correction of micromechanical circuits, such as oscillators and filters. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/537851 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/142 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163626 | Kuzdeba et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott A. Kuzdeba (Hollis, New Hampshire); Brandon P. Hombs (Merrimack, New Hampshire); Peter J. Kajenski (Amherst, New Hampshire); Daniel Massar (Bedford, New Hampshire) |
| ABSTRACT | One or more defined countermeasures are selected from a countermeasure library, populated with parameters, and applied against an unknown, ambiguous, or unresponsive imminent radar threat based on an analysis of a hostile RF waveform emitted by the radar threat. The analysis can include comparing static and/or dynamic features of the hostile RF waveform with features of known hostile RF waveforms. A parameter set associated with the selected defined countermeasure in the countermeasure library can be selected. Waveform features can be categorized and sub-categorized for comparison with the known hostile waveforms. A plurality of features can be detected and compared. The analysis can include correlating behavior patterns of a plurality of hostile RF waveforms emitted by the radar threat. A cognitive intelligence trained using a threat database and library of corresponding countermeasures can analyze the hostile RF waveform, select the defined countermeasure, and/or select or generate the parameters. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 16/953562 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/021 (20130101) G01S 7/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163627 | Kuzdeba et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott A. Kuzdeba (Hollis, New Hampshire); Brandon P. Hombs (Merrimack, New Hampshire); Peter J. Kajenski (Amherst, New Hampshire); Daniel Massar (Bedford, New Hampshire) |
| ABSTRACT | A method of selecting and optimizing a countermeasure for application against a novel, ambiguous, or unresponsive radar threat includes selecting a candidate countermeasure and an initial parameter set and varying at least one of the parameters while the effectiveness of the candidate countermeasure against the radar threat is assessed, for example by a human observer. Embodiments include repeating the process with additional candidate countermeasures. For an unresponsive radar threat, a previously effective countermeasure can be selected as the candidate countermeasure. For an ambiguous radar threat, at least one countermeasure previously verified as effective against a partially matching known threat can be selected as the candidate countermeasure. Correlated parameters can be simultaneously varied. An optimization surface and trajectory formed by a plurality of correlated parameters can be identified by machine intelligence, used to guide the parameter variations, and/or stored for use against the same or similar threats in the future. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 16/953568 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/021 (20130101) G01S 7/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163628 | Kuzdeba et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott A Kuzdeba (Hollis, New Hampshire); Brandon P. Hombs (Merrimack, New Hampshire); Daniel Massar (Bedford, New Hampshire) |
| ABSTRACT | A method of assessing the effectiveness of an electronic countermeasure (ECM) applied against an unknown, ambiguous, or unresponsive radar threat includes monitoring changes in a radar-associated factor while applying the ECM and determining if the ECM is disrupting the hostile radar. The radar-associated factor can be a weapon that is controlled by the radar threat, and assessing the ECM can include determining whether the weapon is misdirected due to applying the ECM. Or the radar-associated factor can be a feature of an RF waveform emitted by the radar threat, and assessing the ECM can include determining if the feature is changed due to applying the ECM. Continuous changes in the feature can indicate unsuccessful attempts to mitigate the ECM. Return of the feature to a pre-threat state can indicate disruption of the radar. The ECM can be selected from a library of countermeasures pre-verified as effective against known threats. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 16/953579 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/021 (20130101) G01S 7/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163629 | Kuzdeba et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | BAE SYSTEMS Information and Electronic Systems Integration Inc. (Nashua, New Hampshire) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Scott A. Kuzdeba (Hollis, New Hampshire); Matthew Anderson (Mont Vernon, New Hampshire); Brandon P. Hombs (Merrimack, New Hampshire); Daniel Massar (Bedford, New Hampshire); John A. Tranquilli, JR. (Amherst, New Hampshire) |
| ABSTRACT | A closed loop, real-time, cognitive Electronic Warfare (EW) system without a threat database includes an EW receiver for receiving radar threat signals; a Signal Analysis and Characterization module; a Pulse to Emitter Association sub-module; a Function De-interleaving Classifier sub-module; a Threat Behavior Model sub-module; a Countermeasures Synthesis module; a Capability, Severity, and Intent sub-module; a Countermeasure Selection sub-module; a Countermeasure Optimization sub-module; a Countermeasures Effectiveness Assessment module; a Resource Management module; and an EW transmitter. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 16/953659 |
| CURRENT CPC | Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 7/021 (20130101) G01S 7/36 (20130101) Original (OR) Class G01S 7/38 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163823 | Phare et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Voyant Photonics, Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher T. Phare (New York, New York); Steven A. Miller (New York, New York); Viraj Shah (New York, New York) |
| ABSTRACT | Disclosed herein are systems and architecture for thermal waveguide-based phase shifters which improve thermal efficiency by having multi-pass waveguides arranged under the heating element in a serpentine fashion, with the waveguides having mismatched propagation constants. The combination allows for an increase in phase shift without increasing the length or the power consumption of the resistive heating element by increasing the total length of waveguide being heated by a singular heating element. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/670554 |
| CURRENT CPC | Devices or Arrangements, the Optical Operation of Which Is Modified by Changing the Optical Properties of the Medium of the Devices or Arrangements for the Control of the Intensity, Colour, Phase, Polarisation or Direction of Light, e.g Switching, Gating, Modulating or Demodulating; Techniques or Procedures for the Operation Thereof; Frequency-changing; Non-linear Optics; Optical Logic Elements; Optical Analogue/digital Converters G02F 1/011 (20130101) G02F 1/0147 (20130101) Original (OR) Class G02F 2203/50 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220164250 | Biran et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Giora Biran (Zichron-Yaakov, Israel); Pradip Bose (Yorktown Heights, New York); Alper Buyuktosunoglu (White Plains, New York); Pierce I-Jen Chuang (Briarcliff Manor, New York); Preetham M. Lobo (BANGALORE, India); Ramon Bertran Monfort (New York, New York); Phillip John Restle (Katonah, New York); Christos Vezyrtzis (New Rochelle, New York); Tobias Webel (Schwaebisch Gmuend, Germany) |
| ABSTRACT | Techniques facilitating voltage droop reduction and/or mitigation in a processor core are provided. In one example, a system can comprise a memory that stores, and a processor that executes, computer executable components. The computer executable components can comprise an observation component that detects one or more events at a first stage of a processor pipeline. An event of the one or more events can be a defined event determined to increase a level of power consumed during a second stage of the processor pipeline. The computer executable components can also comprise an instruction component that applies a voltage droop mitigation countermeasure prior to the increase of the level of power consumed during the second stage of the processor pipeline and a feedback component that provides a notification to the instruction component that indicates a success or a failure of a result of the voltage droop mitigation countermeasure. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/650727 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/28 (20130101) G06F 1/305 (20130101) G06F 1/324 (20130101) G06F 9/3836 (20130101) G06F 11/0721 (20130101) G06F 11/0793 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220164331 | Dewan et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Pranita Sharad Dewan (White Plains, New York); Joao Souto Maior (Jaboatao dos Guararapes, Brazil) |
| ABSTRACT | Embodiments herein describe computer-implemented methods, computer program products and systems for efficient spatial indexing. In an embodiment, the computer-implemented method may include one or more processors configured for obtaining from a database index data representing one or more assets, wherein each of the one or more assets comprise an asset identifier and a spatial attribute; generating a location hash for each of the one or more assets using the respective asset identifier and the respective spatial attribute; determining one or more sets of location hashes based on the asset identifier and the spatial attribute at one of one or more precision values; generating shadow index data comprising the one or more sets of location hashes at the one of one or more precision values; receiving a query corresponding to the index data; and returning a first set of results corresponding to the query in a first query response time. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/104005 |
| CURRENT CPC | Electric Digital Data Processing G06F 16/2228 (20190101) Original (OR) Class G06F 16/24553 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220164510 | Reid et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Raytheon Company (Waltham, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Stephen R. Reid (Ayer, Massachusetts); Sandeep Dutta (Foster City, California) |
| ABSTRACT | A method includes obtaining behavioral source code defining logic to be performed using at least one logic device, hardware information associated with the at least one logic device, and constraints identifying user requirements associated with the at least one logic device. The method also includes generating a design for the at least one logic device using the behavioral source code, the hardware information, and the constraints. The design enables the at least one logic device to execute the logic while satisfying the user requirements. The design is generated using a machine learning/artificial intelligence (ML/AI) algorithm that iteratively modifies potential designs to meet the user requirements. |
| FILED | Wednesday, June 30, 2021 |
| APPL NO | 17/364565 |
| CURRENT CPC | Electric Digital Data Processing G06F 30/343 (20200101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220164636 | Fadaie et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Boeing Company (Chicago, Illinois) |
| ASSIGNEE(S) | The Boeing Company (Chicago, Illinois) |
| INVENTOR(S) | Joshua G. Fadaie (Saint Louis, Missouri); Richard Hanes (Ballwin, Missouri) |
| ABSTRACT | A method including receiving a pre-determined constraint on user actions. A constraint vector is generated based on the pre-determined constraint. The constraint vector is input into a machine learning model. A first output is generated from the machine learning model by executing the machine learning model using the constraint vector as a first input to the machine learning model. The constraint vector is converted into a legal action mask. A probability vector is generated by executing a masked softmax operator. The masked softmax operator takes, as a second input, the first output. The masked softmax operator takes, as a third input, the legal action mask. The masked softmax operator generates, as a second output, the probabilities vector. Action outputs are generated by applying a sampling system to the probability vector. The action outputs include a subset of the user actions, and wherein the subset includes only allowed user actions. |
| FILED | Wednesday, November 17, 2021 |
| APPL NO | 17/529067 |
| CURRENT CPC | Control or Regulating Systems in General; Functional Elements of Such Systems; Monitoring or Testing Arrangements for Such Systems or Elements G05B 13/027 (20130101) Computer Systems Based on Specific Computational Models G06N 3/0454 (20130101) G06N 3/0472 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220164692 | Inoue et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ken Inoue (Elmsford, New York); Maika Takita (Croton-on-Hudson, New York); Antonio Corcoles-Gonzalez (Mount Kisco, New York); Scott Douglas Lekuch (New York, New York) |
| ABSTRACT | Systems, computer-implemented methods, and computer program products that can facilitate determining a state of a qubit are described. According to an embodiment, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise an output receiving component that can receive, in response to a request, output representative of a quantum state of a qubit of a quantum computing device, and a classifying component that classifies the quantum state of the qubit of the quantum computing device based on the output representative of the quantum state of the qubit. The system can further include a configuring component that can configure the classifying component based on a characteristic of the request. |
| FILED | Thursday, November 07, 2019 |
| APPL NO | 16/677178 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6269 (20130101) Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220164694 | Rosenthal et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Universitat Innsbruck (Innsbruck, Austria) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Rosenthal (Boulder, Colorado); Konrad Lehnert (Boulder, Colorado); Christian Schneider (Innsbruck, Austria) |
| ABSTRACT | Technology is disclosed herein that the enhances the measurability and scalability of qubits in a quantum computing environment. In an implementation, a superconducting amplifier device comprises a parametric amplifier and a tunable coupling between the parametric amplifier and a readout cavity external to the superconducting amplifier device. The tunable coupling allows an entangled signal, associated with a qubit in the readout cavity, to transfer from the readout cavity to the parametric amplifier. The parametric amplifier amplifies the entangled signal to produce an amplified signal as output to a measurement sub-system. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/192479 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class Amplifiers H03F 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220164933 | Parameswaran et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | United States Government as represented the Secretary of the Navy (San Diego, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Shibin Parameswaran (San Diego, California); Martin Thomas Jaszewski (San Diego, California) |
| ABSTRACT | A method for processing images comprising: capturing a plurality of degraded images of a first real-world environment with a first sensor; processing each degraded image with a first, untrained convolutional neural network, via a Deep Image Prior approach, to obtain a plurality of clean images, wherein each clean image corresponds to a degraded image; pairing each clean image with its corresponding degraded image to create a plurality of degraded/clean image pairs; training, via a supervised learning approach, a machine learning model to learn a function for converting degraded images into restored images based on the plurality of degraded/clean image pairs; capturing a second plurality of degraded images of a second real-world environment; and using the trained machine learning model to convert the second plurality of degraded images into restored images based on the learned function. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/105135 |
| CURRENT CPC | Image Data Processing or Generation, in General G06T 5/50 (20130101) Original (OR) Class G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220164970 | Andreopoulos et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | INTERNATIONAL BUSINESS MACHINES CORPORATION (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Alexander Andreopoulos (San Jose, California); Hirak Jyoti Kashyap (San Jose, California); Myron D. Flickner (San Jose, California) |
| ABSTRACT | High-framerate real-time spatiotemporal disparity mechanisms on neuromorphic hardware are provided. In various embodiments, a first and second spiking input sensor each output a time series of spikes corresponding to a plurality of frames. A neurosynaptic network is configured to receive the time series of spikes corresponding to the plurality of frames; accumulate the time series of spikes in a ring buffer, thereby creating a plurality of temporal scales; for each corresponding pair of frames from the first and second spiking input sensors, determining a mapping of pixels in one of the pair of frames to pixels in the other of the pair of frames based on similarity; based on the pixel mapping, determining a disparity map. |
| FILED | Wednesday, October 31, 2018 |
| APPL NO | 16/176744 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 3/049 (20130101) Image Data Processing or Generation, in General G06T 5/002 (20130101) G06T 5/30 (20130101) G06T 5/50 (20130101) G06T 7/50 (20170101) Original (OR) Class G06T 2207/20221 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220165529 | Timler et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Science Applications International Corporation (Reston, Virginia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | John P. Timler (River Ridge, Louisiana); Xingcun C. Tong (Bolingbrook, Illinois) |
| ABSTRACT | A thermal fuse may comprise an electrode and a conductor separated by a phase change material. The electrode may be formed from a conductive material that generates hydrogen when exposed to water or hydrogen peroxide. The phase change material may release water or hydrogen peroxide at or above an activation temperature. |
| FILED | Tuesday, November 10, 2020 |
| APPL NO | 17/094577 |
| CURRENT CPC | Electric Switches; Relays; Selectors; Emergency Protective Devices H01H 69/02 (20130101) H01H 85/055 (20130101) Original (OR) Class H01H 85/143 (20130101) H01H 85/0241 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166225 | ROBINSON et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Galvion Soldier Power, LLC (Southborough, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Philip T. ROBINSON (Harvard, Massachusetts); Seth M. DZIENGELESKI (Southbridge, Massachusetts); James D. KAZMIERCZAK (Marlborough, Massachusetts); David J. HOLIGAN (Atkinson, New Hampshire) |
| ABSTRACT | Various aspects of invention provide portable power manager operating methods. One aspect of the invention provides a method for operating a power manager having a plurality of device ports for connecting with external power devices and a power bus for connecting with each device port. The method includes: disconnecting each device port from the power bus when no external power device is connected to the device port; accessing information from newly connected external power devices; determining if the newly connected external power devices can be connected to the power bus without power conversion; if not, determining if the newly connected external power devices can be connected to the power bus over an available power converter; and if so, configuring the available power converter for suitable power conversion. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/671184 |
| CURRENT CPC | Electric Digital Data Processing G06F 1/263 (20130101) G06F 1/266 (20130101) G06F 1/3287 (20130101) G06F 13/4022 (20130101) Circuit Arrangements or Systems for Supplying or Distributing Electric Power; Systems for Storing Electric Energy H02J 1/00 (20130101) H02J 4/00 (20130101) Original (OR) Class H02J 5/00 (20130101) H02J 7/00036 (20200101) H02J 7/00045 (20200101) H02J 7/0068 (20130101) Apparatus for Conversion Between AC and AC, Between AC and DC, or Between DC and DC, and for Use With Mains or Similar Power Supply Systems; Conversion of DC or AC Input Power into Surge Output Power; Control or Regulation Thereof H02M 3/04 (20130101) H02M 5/04 (20130101) H02M 7/04 (20130101) Climate Change Mitigation Technologies in Information and Communication Technologies [ICT] i.e Information and Communication Technologies Aiming at the Reduction of Their Own Energy Use Y02D 10/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166516 | SCHULTZ |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kenneth SCHULTZ (Lexington, Massachusetts) |
| ABSTRACT | Amplitude-modulated (AM) signals spanning a spatial wide area can be efficiently detected using a slowly scanning optical system. The system decouples the AM carrier from the AM signal bandwidth (or carrier uncertainty), enabling Nyquist sampling of only the information-bearing AM signal (or the known frequency bandwidth). The system includes a staring sensor with N pixels (e.g., N>106) that searches for a sinusoidal frequency of unknown phase and frequency, perhaps constrained to a particular band by a priori information about the signal. Counters in the sensor pixels mix the detected signals with local oscillators to down-convert the signal of interest, e.g., to a baseband frequency. The counters store the down-converted signal for read out at a rate lower than the Nyquist rate of AM signal. The counts can be shifted among pixels synchronously with the optical line-of-sight for scanning operation. |
| FILED | Wednesday, February 26, 2020 |
| APPL NO | 16/801276 |
| CURRENT CPC | Transmission H04B 10/541 (20130101) Original (OR) Class H04B 10/1121 (20130101) H04B 10/5561 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220167236 | Melodia et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tommaso Melodia (Newton, Massachusetts); Salvatore D'Oro (Allston, Massachusetts); Michele Polese (Boston, Massachusetts); Leonardo Bonati (Boston, Massachusetts) |
| ABSTRACT | A radio access network (RAN) intelligent controller (RIC) and corresponding method may be implemented within RAN and in next-generation cellular networks to improve performance. The RIC comprises an interface to a RAN and further comprises a data-driven logic unit. The data-driven logic unit (i) produces, based on data received from the RAN via the interface, a representation describing a state of the RAN and (ii) based on the representation describing the state, instructs an action associated with at least one network element. The interface transmits a message based on the action instructed. The message is to be routed to the at least one network element. The representation is based on a context of the RAN. The message transmitted enabling re-configuration of the at least one network element. The re-configuration improves performance of the at least one network element within the context. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/456361 |
| CURRENT CPC | Transmission H04B 17/336 (20150115) Wireless Communication Networks H04W 28/24 (20130101) H04W 28/0236 (20130101) H04W 28/0967 (20200501) H04W 36/06 (20130101) Original (OR) Class H04W 36/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Energy (DOE)
| US 20220160315 | Miller et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Battelle Memorial Institute (Richland, Washington) |
| ASSIGNEE(S) | Battelle Memorial Institute (Richland, Washington) |
| INVENTOR(S) | Erin A. Miller (Richland, Washington); Richard E. Jacob (Kennewick, Washington); Nikhil S. Deshmukh (Everett, Washington); Cynthia L. Warner (Richland, Washington); Richard S. Wittman (Richland, Washington); Luke W. Campbell (Richland, Washington) |
| ABSTRACT | Systems and methods that directly image attenuation-based object grid, use a source grid to improve imaging of the object grid using a high-energy polychromatic source, and use a detector grid having gratings oriented substantially orthogonally to that of the object grid, can address artifacts and beam hardening effects that limit the quality and discriminatory power of high-energy x-ray imaging that includes phase contrast. |
| FILED | Friday, March 20, 2020 |
| APPL NO | 17/442340 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 6/405 (20130101) A61B 6/466 (20130101) A61B 6/484 (20130101) A61B 6/4035 (20130101) A61B 6/4291 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160904 | Strong et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | Fred Hutchinson Cancer Research Center (Seattle, Washington); The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Roland K. Strong (Seattle, Washington); Peter Rupert (Seattle, Washington); Rebecca J. Abergel (Berkeley, California); Ilya Captain (Moraga, California); Gauthier JP Deblonde (Berkeley, California) |
| ABSTRACT | Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes. |
| FILED | Friday, December 10, 2021 |
| APPL NO | 17/643734 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 51/0478 (20130101) A61K 51/0482 (20130101) Original (OR) Class Separation B01D 15/34 (20130101) B01D 15/3804 (20130101) Peptides C07K 14/47 (20130101) Production and Refining of Metals; Pretreatment of Raw Materials C22B 60/02 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161230 | Britt et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | David Britt (El Cerrito, California); Daniel Sun (Sion, Switzerland); Wendy Queen (Grimisuat, Switzerland) |
| ABSTRACT | A composition of matter for selective binding of at least one heavy metal comprising at least one porous metal-organic framework (MOF) with unsaturated coordination sites, at least one organic ligand functionalized with at least one functional group tailored to bind to the at least one MOF, and at least one separate functional group tailored to bind to the at least one heavy metal. |
| FILED | Tuesday, January 11, 2022 |
| APPL NO | 17/573071 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 20/226 (20130101) Original (OR) Class B01J 20/28033 (20130101) Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/281 (20130101) C02F 1/285 (20130101) C02F 2101/20 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161298 | Kumar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sortera Alloys, Inc. (Fort Worth, Texas) |
| ASSIGNEE(S) | Sortera Alloys, Inc. (Fort Worth, Texas) |
| INVENTOR(S) | Nalin Kumar (Fort Worth, Texas); Manuel Gerardo Garcia, JR. (Fort Wayne, Indiana); Isha Kamleshbhai Maun (Arlington, Texas) |
| ABSTRACT | Systems and methods for classifying and sorting of plastic materials utilizing a vision system and one or more sensor systems, which may implement a machine learning system in order to identify or classify each of the materials, which may then be sorted into separate groups based on such an identification or classification. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667397 |
| CURRENT CPC | Postal Sorting; Sorting Individual Articles, or Bulk Material Fit to be Sorted Piece-meal, e.g by Picking B07C 5/04 (20130101) B07C 5/34 (20130101) B07C 5/342 (20130101) B07C 5/3422 (20130101) Original (OR) Class B07C 2501/0054 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161322 | Tappan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| ASSIGNEE(S) | Triad National Security, LLC (Los Alamos, New Mexico) |
| INVENTOR(S) | Bryce Tappan (Santa Fe, New Mexico); Andrew Schmalzer (Los Alamos, New Mexico); Alexander H. Mueller (Santa Fe, New Mexico) |
| ABSTRACT | Processes for tailoring the macroscopic shape, metallic composition, mechanical properties, and pore structure of nanoporous metal foams prepared through combustion synthesis via direct write 3D printing of metal energetic ligand precursor inks made with water and an organic thickening agent are disclosed. Such processes enable production of never before obtainable metal structures with hierarchical porosity, tailorable from the millimeter size regime to the nanometer size regime. Structures produced by these processes have numerous applications including, but not limited to, catalysts, heat exchangers, low density structural materials, biomedical implants, hydrogen storage medium, fuel cells, and batteries. |
| FILED | Wednesday, February 09, 2022 |
| APPL NO | 17/668329 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 3/1121 (20130101) Original (OR) Class B22F 10/00 (20210101) B22F 10/60 (20210101) B22F 2998/00 (20130101) Coating Compositions, e.g Paints, Varnishes or Lacquers; Filling Pastes; Chemical Paint or Ink Removers; Inks; Correcting Fluids; Woodstains; Pastes or Solids for Colouring or Printing; Use of Materials Therefor C09D 11/52 (20130101) Alloys C22C 1/08 (20130101) Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/092 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161332 | KHAIRALLAH et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California); Seurat Technologies, Inc. (Wilmington, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Saad A. KHAIRALLAH (Livermore, California); John ROEHLING (Livermore, California); Yiyu SHEN (Tewksbury, Massachusetts); Andrew James BAYRAMIAN (Marblehead, Massachusetts); Ning DUANMU (Nashua, New Hampshire); James A. DEMUTH (Woburn, Massachusetts) |
| ABSTRACT | The present disclosure relates to systems and methods for performing large area laser powder bed fusion (LBPF) to form a plurality of layers of a 3D part in a layer-by-layer fashion using meltable powder particles. In one implementation the system makes use of a first light source, which may be a diode laser subsystem, for generating a first light pulse of a first duration. The first light is used to preheat a substrate underneath a new layer of powder particles, wherein the substrate is formed from a previously fused quantity of the powder particles. A second light source, which may be a pulse laser, generates a second light pulse subsequent to the first light pulse. The second light pulse has a second duration shorter than the first duration by a factor of at least about 10, and fully melts the new layer of powder particles in addition to the substrate, to achieve a smooth printed layer. The wavelength of the first light pulse also differs from a wavelength of the second light pulse. |
| FILED | Monday, October 04, 2021 |
| APPL NO | 17/492832 |
| CURRENT CPC | Working Metallic Powder; Manufacture of Articles From Metallic Powder; Making Metallic Powder B22F 10/28 (20210101) B22F 12/43 (20210101) Original (OR) Class Soldering or Unsoldering; Welding; Cladding or Plating by Soldering or Welding; Cutting by Applying Heat Locally, e.g Flame Cutting; Working by Laser Beam B23K 26/342 (20151001) B23K 26/0608 (20130101) B23K 26/0622 (20151001) Additive Manufacturing, i.e Manufacturing of Three-dimensional [3-D] Objects by Additive Deposition, Additive Agglomeration or Additive Layering, e.g by 3-d Printing, Stereolithography or Selective Laser Sintering B33Y 10/00 (20141201) B33Y 30/00 (20141201) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161381 | Karandikar et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UT-Battelle, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jaydeep M. Karandikar (Oak Ridge, Tennessee); Thomas A. Feldhausen (Oak Ridge, Tennessee); Kyle S. Saleeby (Oak Ridge, Tennessee); Kevin S. Smith (Oak Ridge, Tennessee); Tony L. Schmitz (Oak Ridge, Tennessee) |
| ABSTRACT | A Bayesian learning approach for stability boundary and optimal parameter identification in milling without the knowledge of the underlying tool dynamics or material cutting force coefficients. Different axial depth and spindle speed combinations are characterized by a probability of stability which is updated based upon whether the result is stable or unstable. A likelihood function incorporates knowledge of stability behavior. Numerical results show convergence to an analytical stability lobe diagram. An adaptive experimental strategy identifies optimal operating parameters that maximize material removal rate. An efficient and robust learning method to identify the stability lobe diagram and optimal operating parameters with a limited number of tests/data points. |
| FILED | Thursday, November 18, 2021 |
| APPL NO | 17/529558 |
| CURRENT CPC | Details, Components, or Accessories for Machine Tools, e.g Arrangements for Copying or Controlling; Machine Tools in General Characterised by the Construction of Particular Details or Components; Combinations or Associations of Metal-working Machines, Not Directed to a Particular Result B23Q 15/12 (20130101) B23Q 17/12 (20130101) B23Q 17/0976 (20130101) Original (OR) Class Computer Systems Based on Specific Computational Models G06N 20/00 (20190101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161487 | Barr et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Honeywell Federal Manufacturing and Technologies (Kansas City, Missouri) |
| ASSIGNEE(S) | Honeywell Federal Manufacturing and Technologies, LLC (Kansas CIty, Missouri) |
| INVENTOR(S) | Christian G. Barr (Kansas City, Missouri); George W. Bohnert (Harrisonville, Missouri) |
| ABSTRACT | Methods and assemblies for additive manufacturing portions of components with enhanced strength are provided. The assemblies comprise a first deposition head and an apparatus for causing one or more reinforcement fibers to extend more than two layers within previously-deposited layers of build material. The first deposition head is configured to deposit a plurality of layers of a filament comprising a reinforcement fiber and thermoplastic material. The apparatus may comprise a needle point configured to be inserted into the plurality of layers to displace the reinforcement fiber so that it extends two or more of the plurality of layers. The apparatus may additionally or alternatively comprise a second deposition head having a needle tip configured to be inserted into the plurality of layers to inject a length of a second filament comprising thermoplastic material and a reinforcement fiber so that the reinforcement fiber of the second filament extends two or more layers of the plurality of layers of the first filament. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/670976 |
| CURRENT CPC | Shaping or Joining of Plastics; Shaping of Material in a Plastic State, Not Otherwise Provided For; After-treatment of the Shaped Products, e.g Repairing B29C 64/25 (20170801) B29C 64/118 (20170801) Original (OR) Class B29C 64/188 (20170801) B29C 64/209 (20170801) B29C 64/227 (20170801) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162094 | Gadgil et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California) |
| INVENTOR(S) | Ashok Jagannath Gadgil (Berkeley, California); Arkadeep Kumar (Berkeley, California); Mohit Nahata (Berkeley, California); Siva Rama Satyam Bandaru (Berkeley, California) |
| ABSTRACT | Iron electrocoagulation (Fe-EC) reactors for removing contaminants from water comprising an assembly of spiral-wound or folded iron-containing anode and cathode plates separated with perforated insulating spacers, or an oxidant to accelerate oxidation of Fe(II) ions released from the anode to obtain Fe(III) ions, and/or to oxidize the contaminant. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/670560 |
| CURRENT CPC | Treatment of Water, Waste Water, Sewage, or Sludge C02F 1/463 (20130101) Original (OR) Class C02F 1/46109 (20130101) C02F 2101/103 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162268 | Young et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | Board of Trustees of Michigan State University (East Lansing, Michigan) |
| INVENTOR(S) | Eric Jeffrey Young (Berkeley, California); Cheryl A. Kerfeld (Melrose, Minnesota); Daniel Christopher Ducat (Lancing, Michigan) |
| ABSTRACT | Described herein are constructs, compositions and methods for precise in vivo imaging of the structures and dynamics of protein-based scaffolds with and without their designated cargos. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531183 |
| CURRENT CPC | Peptides C07K 14/195 (20130101) Original (OR) Class C07K 2319/00 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/70 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162651 | Trego et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Synvitrobio, Inc. (San Francisco, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Kelly S. Trego (San Francisco, California); Louis E. Metzger, IV (San Francisco, California); Abel C. Chiao (San Francisco, California); Zachary Z. Sun (San Francisco, California); Dan E. Robertson, IV (San Franciso, California); Benjamin Mohr (San Franciso, California) |
| ABSTRACT | Compositions and methods disclosed herein relate to improved in vitro cell-free systems for various biological reactions. In one aspect, a composition of the present disclosure includes: a cell-free extract derived from an organism; a nucleic acid; and an organelle that is heterologous to the organism. |
| FILED | Monday, March 09, 2020 |
| APPL NO | 17/437288 |
| CURRENT CPC | Peptides C07K 14/43504 (20130101) Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 7/42 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162762 | Wong |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Andrew Wong (Emeryville, California) |
| ABSTRACT | An electrode includes a substrate having a body and a plurality of elongate first lands projecting away from the body. Each pair of adjacent lands define a channel therebetween, where the plurality of elongate first lands defines a plurality of first channels. The substrate defines an x-y-z coordinate system, where each of the plurality of elongate first lands defines a longitudinal axis about parallel to the x-y plane. Moreover, each of the plurality of elongate first lands projects away from the body by a height in the z-direction. In addition, the electrode includes an inlet and an outlet where the plurality of first channels are configured to allow flow of fluid from the inlet to the outlet. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532974 |
| CURRENT CPC | Electrolytic or Electrophoretic Processes for the Production of Compounds or Non-metals; Apparatus Therefor C25B 3/03 (20210101) C25B 3/26 (20210101) C25B 11/02 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163130 | Sabharwall et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Paul Marotta (Jersey, New Jersey); Battelle Energy Alliance, LLC (Idaho Falls, Idaho); University of Idaho (Moscow, Idaho) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Piyush Sabharwall (Idaho Falls, Idaho); Richard N. Christensen (Idaho Falls, Idaho); Paul Marotta (Jersey City, New Jersey) |
| ABSTRACT | Valves may include an opening sized and shaped to permit a subject fluid to flow through the opening when the opening is unobstructed. A heat exchange element may be located proximate to the opening, the heat exchange element positioned and configured to induce a localized phase change in the subject fluid to form and unform a solid plug from the subject fluid around at least a portion of the heat exchange element. A heat transfer rate of the heat exchange element may be variable to control a rate of flow of the subject fluid through the valve by controlling a size of the solid plug from the subject fluid. |
| FILED | Monday, November 08, 2021 |
| APPL NO | 17/453980 |
| CURRENT CPC | Valves; Taps; Cocks; Actuating-floats; Devices for Venting or Aerating F16K 31/002 (20130101) Original (OR) Class Systems for Controlling or Regulating Non-electric Variables G05D 7/01 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163202 | Lisowski et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| ASSIGNEE(S) | UCHICAGO ARGONNE, LLC (Chicago, Illinois) |
| INVENTOR(S) | Darius D. Lisowski (Chicago, Illinois); Dennis J. Kilsdonk (Joliet, Illinois) |
| ABSTRACT | The invention provides a device for removing heat from a building, the device having: a first tubular member defining a first cavity; a second tubular member defining a second cavity, whereby said second tubular member resides within the first cavity and is coaxial to the first tubular member; a double conic body coaxially residing in the first cavity and coaxially positioned with the second tubular member; and a flange dimensioned to extend over at least a portion of the periphery of the existing flue so as to aid in supporting the device on the flue. |
| FILED | Wednesday, January 12, 2022 |
| APPL NO | 17/574356 |
| CURRENT CPC | Removal or Treatment of Combustion Products or Combustion Residues; Flues F23J 13/06 (20130101) F23J 13/025 (20130101) Original (OR) Class F23J 2213/50 (20130101) Supplying Air or Non-combustible Liquids or Gases to Combustion Apparatus in General; Valves or Dampers Specially Adapted for Controlling Air Supply or Draught in Combustion Apparatus; Inducing Draught in Combustion Apparatus; Tops for Chimneys or Ventilating Shafts; Terminals for Flues F23L 17/02 (20130101) Casings, Linings, Walls or Doors Specially Adapted for Combustion Chambers, e.g Firebridges; Devices for Deflecting Air, Flames or Combustion Products in Combustion Chambers; Safety Arrangements Specially Adapted for Combustion Apparatus; Details of Combustion Chambers, Not Otherwise Provided for F23M 9/006 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163384 | SCHUCK et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | P. JAMES SCHUCK (New York, New York); CHANGWAN LEE (New York, New York); EMMA XU (New York, New York); KAIYUAN YAO (New York, New York); EMORY CHAN (Oakland, California); BRUCE COHEN (San Francisco, California); AYELET TEITELBOIM (Berkeley, California); YAWEI LIU (Heilongjiang Province, China PRC); YUNG DOUG SUH (Seoul, South Korea); SANG HWAN NAM (Seoul, South Korea) |
| ABSTRACT | Exemplary nanoparticle and method for inducing photon avalanching using a nanoparticle can be provided. The nanoparticle can include, for example, at least 99% thulium doped nanocrystals of the nanoparticle. The nanoparticle can be composed of solely thulium. An atomic concentration of the thulium can be at least 8%. A near infrared excitation wavelength of the nanocrystals can be greater than about 1064 nm. The near infrared excitation wavelength can be between about 1400 nm to about 1490 nm. A passivated shell(s) can be included which can surround the nanocrystals. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531266 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 1/42 (20130101) Original (OR) Class G01J 2001/4466 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163499 | Hanson et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | David Hanson (Albuquerque, New Mexico); Patrick Joseph Hudson (Albuquerque, New Mexico); Kaitlyn Johanna Hughes READ (Albuquerque, New Mexico); Laura Green (Albuquerque, New Mexico); Joseph Stinziano (Albuquerque, New Mexico); Tito Busani (Albuquerque, New Mexico); Mahmoud Behzadirad (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| INVENTOR(S) | David Hanson (Albuquerque, New Mexico); Patrick Joseph Hudson (Albuquerque, New Mexico); Kaitlyn Johanna Hughes READ (Albuquerque, New Mexico); Laura Green (Albuquerque, New Mexico); Joseph Stinziano (Albuquerque, New Mexico); Tito Busani (Albuquerque, New Mexico); Mahmoud Behzadirad (Albuquerque, New Mexico) |
| ABSTRACT | Methods and apparatus for electrical impedance spectroscopy for non-destructive, real-time, tracking of relative water content and stress responses in plants. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 17/599085 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/223 (20130101) G01N 33/0098 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163980 | Beer et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Lawrence Livermore National Security, LLC (Livermore, California) |
| ASSIGNEE(S) | |
| INVENTOR(S) | N. Reginald Beer (Pleasanton, California); Jacob Trueblood (Dublin, California); Brian Matthew Wihl (Pleasanton, California) |
| ABSTRACT | A system for determining a travel direction that avoids objects when a vehicle travels from a current location to a target location is provided. The system determines a travel direction based on an attract-repel model. The system accesses external object information provided by an external object system. The external object information may include, for each of a plurality of objects, location, type, and constraint. The system assigns a repel value to the location of each object based on the type of and constraint on the object. The system assigns an attractive value to the target location. The system calculates a cumulative force based on the attractive and repulsive forces and sets the travel direction based on the cumulative force. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/103642 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 39/024 (20130101) B64C 2201/141 (20130101) Systems for Controlling or Regulating Non-electric Variables G05D 1/0088 (20130101) G05D 1/1064 (20190501) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220165488 | Yao et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Yuan Yao (Tarrytown, New York); Todd Edward Takken (Brewster, New York); Xin Zhang (Chappaqua, New York); Andrew Ferencz (Southborough, Massachusetts); Shurong Tian (Mount Kisco, New York) |
| ABSTRACT | An approach for reducing unwanted magnetic coupling with conductive elements by keeping the localized magnetic field in a transformer's or inductors magnetic gap far away from any conductive elements is provided. The approach includes the use of spacers to keep the localized magnetic field in a transformer's or inductor's magnetic gap far away from any conductive elements to reduce unwanted magnetic coupling with those conductive elements. The spacers can be made from materials including ferrite, conductors and non-conducting elements. |
| FILED | Wednesday, November 25, 2020 |
| APPL NO | 17/104173 |
| CURRENT CPC | Magnets; Inductances; Transformers; Selection of Materials for Their Magnetic Properties H01F 27/06 (20130101) H01F 27/24 (20130101) H01F 27/34 (20130101) Original (OR) Class H01F 27/2804 (20130101) H01F 2027/065 (20130101) H01F 2027/348 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220165888 | Yates et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | National Technology and Engineering Solutions of Sandia, LLC (Albuquerque, New Mexico) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Luke Yates (Albuquerque, New Mexico); Brendan P. Gunning (Albuquerque, New Mexico); Mary H. Crawford (Albuquerque, New Mexico); Jeffrey Steinfeldt (Rio Rancho, New Mexico); Michael L. Smith (Albuquerque, New Mexico); Vincent M. Abate (Albuquerque, New Mexico); Jeramy R. Dickerson (Edgewood, New Mexico); Andrew M. Armstrong (Los Ranchos de Albuquerque, New Mexico); Andrew Binder (Albuquerque, New Mexico); Andrew A. Allerman (Tijeras, New Mexico); Robert J. Kaplar (Albuquerque, New Mexico); Jack David Flicker (Albuquerque, New Mexico); Gregory W. Pickrell (Rio Rancho, New Mexico) |
| ABSTRACT | A vertical gallium nitride (GaN) PN diode uses epitaxial growth of a thick drift region with a very low carrier concentration and a carefully designed multi-zone junction termination extension to achieve high voltage blocking and high-power efficiency. An exemplary large area (1 mm2) diode had a forward pulsed current of 3.5 A, an 8.3 mΩ-cm2 specific on-resistance, and a 5.3 kV reverse breakdown. A smaller area diode (0.063 mm2) was capable of 6.4 kV breakdown with a specific on-resistance of 10.2 mΩ-cm2, when accounting for current spreading through the drift region at a 45° angle. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/572360 |
| CURRENT CPC | Semiconductor Devices; Electric Solid State Devices Not Otherwise Provided for H01L 29/452 (20130101) H01L 29/2003 (20130101) H01L 29/8611 (20130101) Original (OR) Class H01L 29/66136 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166021 | Siu et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Research Foundation for The State University of New York (Binghamton, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Carrie Siu (Philadelphia, Pennsylvania); M. Stanley Whittingham (Vestal, New York) |
| ABSTRACT | The epsilon polymorph of vanadyl phosphate, ε-VOPO4, made from the solvothermally synthesized H2VOPO4, is a high density cathode material for lithium-ion batteries optimized to reversibly intercalate two Li-ions to reach the full theoretical capacity at least 50 cycles with a coulombic efficiency of 98%. This material adopts a stable 3D tunnel structure and can extract two Li-ions per vanadium ion, giving a theoretical capacity of 305 mAh/g, with an upper charge/discharge plateau at around 4.0 V, and one lower at around 2.5 V. |
| FILED | Sunday, February 13, 2022 |
| APPL NO | 17/670470 |
| CURRENT CPC | Non-metallic Elements; Compounds Thereof; C01B 25/372 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/136 (20130101) H01M 4/623 (20130101) H01M 4/625 (20130101) H01M 4/1397 (20130101) H01M 4/5825 (20130101) Original (OR) Class H01M 10/0525 (20130101) H01M 2004/021 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166065 | Armstrong et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | UT-BATTELLE, LLC (Oak Ridge, Tennessee) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Beth L. Armstrong (Oak Ridge, Tennessee); Gabriel M. Veith (Knoxville, Tennessee); Sergiy Kalnaus (Knoxville, Tennessee); Hsin Wang (Knoxville, Tennessee); Katie L. Browning (Oak Ridge, Tennessee); Kevin M. Cooley (Knoxville, Tennessee) |
| ABSTRACT | A method of making a passively impact resistant battery includes the steps of providing a porous separator material having pores and a surface, and providing a suspension composition including shear thickening enabling particles and a particle suspension solvent for suspending the shear thickening enabling particles. The shear thickening particles have a polydispersity index of no greater than 0.1, an average particle size of in a range of 50 nm to 1 um, and an absolute zeta potential of greater than ±40 mV. The suspension composition is applied to the separator material, wherein a portion of the particles and suspension solvent penetrate the pores. The suspension solvent is evaporated from the separator material. An anode layer and a cathode layer are applied. An electrolyte composition is applied between the anode layer and the cathode layer. The electrolyte composition includes an electrolyte solvent and an electrolyte salt. |
| FILED | Friday, January 07, 2022 |
| APPL NO | 17/570982 |
| CURRENT CPC | Lime, Magnesia; Slag; Cements; Compositions Thereof, e.g Mortars, Concrete or Like Building Materials; Artificial Stone; Ceramics; Refractories; Treatment of Natural Stone C04B 41/88 (20130101) Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 10/052 (20130101) H01M 10/0567 (20130101) Original (OR) Class H01M 10/0568 (20130101) H01M 10/0569 (20130101) H01M 2300/0028 (20130101) H01M 2300/0085 (20130101) H01M 2300/0094 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166414 | Wu |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| ASSIGNEE(S) | Fermi Research Alliance, LLC (Batavia, Illinois) |
| INVENTOR(S) | Jinyuan Wu (Aurora, Illinois) |
| ABSTRACT | A pure digital ring oscillator with constant power consumption as oscillation frequency is adjusted. Circuit topology includes a multiplexer implemented in NAND gates and a delay element positioned after a path selection NAND gate of that multiplexer such that delay element transistors may not toggle if the non-delaying signal path is selected. Assuming a delay element oscillation frequency f and a total capacitance C, and also assuming a plurality N of delay gates each characterized by a propagation delay t1 and a capacitance C1 such that C=C1*N, the ring oscillator of the present invention is characterized by a C value that is proportional to N and an f value that is inversely proportional to N. Furthermore, each of the N delay gates as well as the input and output gates of the multiplexer are characterized by a common capacitance-to-propagation delay ratio=C1/t1. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/669338 |
| CURRENT CPC | Pulse Technique H03K 3/012 (20130101) H03K 3/0315 (20130101) Original (OR) Class H03K 5/00 (20130101) H03K 19/20 (20130101) H03K 2005/00078 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166705 | Froese |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edwin L. Froese (Burnaby British Columbia, California) |
| ABSTRACT | Systems and methods are provided for managing a data communication within a multi-level network having a plurality of switches organized as groups, with each group coupled to all other groups via global links, including: at each switch within the network, maintaining a global fault table identifying the links which lead only to faulty global paths, and when the data communication is received at a port of a switch, determine a destination for the data communication and, route the communication across the network using the global fault table to avoid selecting a port within the switch that would result in the communication arriving at a point in the network where its only path forward is across a global link that is faulty; wherein the global fault table is used for both a global minimal routing methodology and a global non-minimal routing methodology. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594711 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/22 (20130101) H04L 45/028 (20130101) H04L 45/28 (20130101) Original (OR) Class H04L 45/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220167501 | Nicholas et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board Of Trustees Of Michigan State University (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jason Dale Nicholas (Okemos, Michigan); Quan Zhou (Farmington Hills, Michigan); Thomas Rector Bieler (East Lansing, Michigan) |
| ABSTRACT | The disclosure generally relates to a method of creating patterned metallic circuits (e.g., silver circuits) on a substrate (e.g., a ceramic substrate). A porous metal interlayer (e.g., porous nickel) is applied to the substrate to improve wetting and adhesion of the patterned metal circuit material to the substrate. The substrate is heated to a temperature sufficient to melt the patterned metal circuit material but not the porous metal interlayer. Spreading of molten metal circuit material on the substrate is controlled by the porous metal interlayer, which can itself be patterned, such as having a defined circuit pattern. Thick-film silver or other metal circuits can be custom designed in complicated shapes for high temperature/high power applications. The materials designated for the circuit design allows for a low-cost method of generating silver circuits other metal circuits on a ceramic substrate. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/668660 |
| CURRENT CPC | Printed Circuits; Casings or Constructional Details of Electric Apparatus; Manufacture of Assemblages of Electrical Components H05K 1/0306 (20130101) Original (OR) Class H05K 3/22 (20130101) H05K 3/1208 (20130101) H05K 3/3478 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Science Foundation (NSF)
| US 20220160601 | MIlczek et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Curie Co. Inc. (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Erika M. MIlczek (New York, New York); William Shindel (New York, New York); Zsolt Szabados (New York, New York) |
| ABSTRACT | Sunscreen compositions and sunscreen active ingredients are disclosed herein which comprise at least one ketone-containing UV filter and at least one primary or secondary amine wherein at least one ketone-containing UV filter and at least one primary or secondary amine react to form an imine analog of the ketone-containing UV filter wherein the imine analog has at least one property selected from the group consisting of a) is capable of extending UV protection into a visible region equal to or greater than 400 nm, b) is water resistant, and/or c) prevents or decreases skin penetration. This imine analog may be further modified to provide a substrate capable of reacting with transglutaminase or any variant thereof and/or a lysyl oxidase to bind the sunscreen composition or sunscreen active ingredient to a target of interest. Also disclosed are cosmetic or pharmaceutical preparations comprising any of the sunscreen compositions or sunscreen ingredients along with a cosmetically or pharmaceutically acceptable carrier. |
| FILED | Thursday, November 11, 2021 |
| APPL NO | 17/524222 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 8/40 (20130101) Original (OR) Class A61K 8/64 (20130101) A61K 8/445 (20130101) A61K 8/466 (20130101) A61K 8/891 (20130101) Specific Use of Cosmetics or Similar Toilet Preparations A61Q 17/04 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160631 | Shukla et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BROWN UNIVERSITY (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Anita Shukla (Providence, Rhode Island); Sarah Cowles (Bedford, Massachusetts); Noel Vera-Gonzalez (San Juan, Puerto Rico); Christina Bailey-Hytholt (Millbury, Massachusetts); Eli Silvert (Woodbridge, Connecticut) |
| ABSTRACT | The invention provides functionalized antifungal-loaded liposomal formulations targeting Candida, which minimize damage to healthy human cells, limit antimicrobial exposure, and reduce the development of antifungal resistance. |
| FILED | Monday, January 31, 2022 |
| APPL NO | 17/589554 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/127 (20130101) Original (OR) Class A61K 38/12 (20130101) A61K 47/14 (20130101) A61K 47/42 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/10 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160877 | Mayes et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sarah Mayes (Austin, Texas); Christine Schmidt (Gainesville, Florida) |
| ABSTRACT | The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/669455 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/738 (20130101) A61K 47/36 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160891 | Green et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | THE JOHNS HOPKINS UNIVERSITY (Baltimore, Maryland) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jordan J. Green (Baltimore, Maryland); Stephany Yi Tzeng (Baltimore, Maryland); Kelly Rhodes (Baltimore, Maryland); Giorgio Raimondi (Baltimore, Maryland); Marcos Iglesias (Baltimore, Maryland); Jamie Spangler (Baltimore, Maryland); Jakub Tomala (Baltimore, Maryland); Derek VanDyke (Baltimore, Maryland); Randall A. Meyer (Baltimore, Maryland) |
| ABSTRACT | The disclosure is directed to a biodegradable particle comprising a polyester or polyester blend, a first protein that binds to an immune cell, and a second protein that promotes proliferation and/or activation of immune cells, and a third soluble protein or small molecule encapsulated within the particle. The second protein is a fusion protein comprising at least a portion of an antibody and at least a portion of a cytokine (i.e., an immunocytokine). The disclosure also is directed to methods for treating a disease or condition in a subject (e.g., an autoimmune disease) comprising administering the aforementioned biodegradable particle to the subject. |
| FILED | Monday, April 13, 2020 |
| APPL NO | 17/602856 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/5031 (20130101) A61K 31/436 (20130101) A61K 47/62 (20170801) A61K 47/6813 (20170801) A61K 47/6845 (20170801) A61K 47/6849 (20170801) A61K 47/6937 (20170801) Original (OR) Class Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 37/00 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161217 | BORDEN et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | TRULY OXYGEN INCORPORATED (Boulder, Colorado) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mark A. BORDEN (Boulder, Colorado); Edward SWANSON (New York, New York) |
| ABSTRACT | Systems, methods, and devices are described to synthesize gas-filled microbubbles using a continuous flow chamber with a reaction volume and a sonicator positioned therein, by flowing a lipid solution at a first flow rate and gas at a first pressure into the reaction volume while ultrasonically agitating an interface between the lipid solution and the gas in the reaction volume using the sonicator member to generate a solution of gas-filled microbubbles, which solution can be concentrated to obtain a concentrated solution of microbubbles containing at least 23% of the core gas by volume. |
| FILED | Thursday, October 14, 2021 |
| APPL NO | 17/501963 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 49/223 (20130101) Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 13/04 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161245 | Rovis et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Trustees of Columbia University in the City of New York (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tomislav Rovis (Scarsdale, New York); David Cabanero (New York, New York) |
| ABSTRACT | The present disclosure provides compositions and methods for metathesizing a first alkenyl or alkynyl group with a second alkenyl or alkynyl group, the composition comprising a ruthenium metathesis catalyst and a photo-redox catalyst that is activated by infrared light. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532353 |
| CURRENT CPC | Chemical or Physical Processes, e.g Catalysis or Colloid Chemistry; Their Relevant Apparatus B01J 31/1815 (20130101) B01J 31/2273 (20130101) Original (OR) Class B01J 35/004 (20130101) B01J 2231/543 (20130101) B01J 2531/821 (20130101) B01J 2531/825 (20130101) Acyclic or Carbocyclic Compounds C07C 6/06 (20130101) C07C 41/32 (20130101) C07C 67/035 (20130101) C07C 2601/10 (20170501) Heterocyclic Compounds C07D 207/48 (20130101) C07D 223/04 (20130101) C07D 309/18 (20130101) Macromolecular Compounds Obtained Otherwise Than by Reactions Only Involving Unsaturated Carbon-to-carbon Bonds C08G 61/08 (20130101) C08G 2261/228 (20130101) C08G 2261/418 (20130101) C08G 2261/3325 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220161920 | DI LUCA et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Brown University (Providence, Rhode Island) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Matteo DI LUCA (Arlington, Massachusetts); Kenneth BREUER (Newton, Massachusetts) |
| ABSTRACT | A free-streamline airfoil includes a lower surface which is flat or contoured, and an upper surface that is curved or made of discrete flat elements approximating a curved surface, the upper surface presenting a cavity, a cavity width in an airfoil chordwise direction shorter than the airfoil chord, a position and depth of the cavity triggering a turbulent flow over the airfoil's suction side while preserving the airfoil physical integrity. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/534802 |
| CURRENT CPC | Aeroplanes; Helicopters B64C 3/14 (20130101) Original (OR) Class B64C 23/06 (20130101) B64C 2003/149 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162235 | Braddock-Wilking et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Curators Of The University Of Missouri (Columbia, Missouri) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Janet Braddock-Wilking (St. Louis, Missouri); Cynthia M. Dupureur (St. Louis, Missouri); Stephan Germann (St. Louis, Missouri); Helena Spikes (St. Louis, Missouri) |
| ABSTRACT | Described herein are luminescent sila- and germafluorenes. Also described herein are methods of making and using sila- and germafluorenes. The position and the type of substituent impact the absorption and emission properties in solution and in the solid-state and subsequently influence the role of sila- and germafluorenes as biosensors. |
| FILED | Thursday, April 09, 2020 |
| APPL NO | 17/594282 |
| CURRENT CPC | Acyclic, Carbocyclic or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen, Sulfur, Selenium or Tellurium C07F 7/30 (20130101) C07F 7/083 (20130101) C07F 7/0816 (20130101) Original (OR) Class Materials for Miscellaneous Applications, Not Provided for Elsewhere C09K 11/06 (20130101) C09K 2211/1018 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/02 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 1/30 (20130101) G01N 21/6428 (20130101) G01N 2001/302 (20130101) G01N 2021/6439 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162346 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Trustees of the University of Arkansas (Little Rock, Arkansas) |
| ASSIGNEE(S) | Board of Trustees of the University of Arkansas (Little Rock, Arkansas) |
| INVENTOR(S) | Jin-Woo Kim (Fayetteville, Arkansas); Joseph Batta-Mpouma (Fayetteville, Arkansas); Joshua Sakon (Fayetteville, Arkansas) |
| ABSTRACT | This invention relates generally to covalently crosslinked colloidal cellulose nanocrystals (xCNC) and methods of preparation and use thereof. The colloidal cellulose nanocrystals (CNCs) are covalently crosslinked in aqueous suspension to generate a network showing tunable physicochemical properties. The xCNC structures are tunable in terms of their physicochemical properties and arrangement within the hydrogel network. The covalent crosslinking of solitary sulfonated (—OSO3) CNCs can be accomplished without prior hydroxyl replacement or functionalization. |
| FILED | Monday, September 20, 2021 |
| APPL NO | 17/479053 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Polysaccharides; Derivatives Thereof C08B 15/08 (20130101) C08B 15/10 (20130101) Original (OR) Class Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/07 (20130101) C08K 5/1515 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162402 | Rabnawaz et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (East Lansing, Michigan) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Muhammad Rabnawaz (East Lansing, Michigan); Muhammad Naveed (East Lansing, Michigan) |
| ABSTRACT | The disclosure relates to thermally reversibly crosslinked polyolefins (TRC-PO) and methods for making the same. A TRC-PO can be formed by reactive melt-processing a mixture including (i) a polyolefin, (ii) an initiator, and (iii) a reversible crosslinker. The reversible crosslinker includes (A) a grafting agent moiety selected from unsaturated cyclic anhydrides, unsaturated cyclic imides, cyclic nitroxides, and ring-opened analogs thereof, and (B) a crosslinking moiety bound to the cyclic grafting agent moiety. This reactive melt-processing, for example including reactive extrusion, forms a thermally reversibly crosslinked (TRC) polyolefin with polyolefin chains reversibly crosslinked via the reversible crosslinkers, which provide dynamic covalent bonds, such as siloxanes and esters, that are amenable to melt re-processing to re-from or otherwise re-use the TRC-PO while still retaining the reversible crosslinks after re-processing. Catalysts and additives such as rheology modifiers can be added to the melt-processing mixture. |
| FILED | Monday, November 22, 2021 |
| APPL NO | 17/532610 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/243 (20130101) Original (OR) Class C08J 11/18 (20130101) C08J 2323/06 (20130101) C08J 2323/12 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 5/14 (20130101) C08K 5/20 (20130101) C08K 5/0025 (20130101) C08K 5/053 (20130101) C08K 5/1539 (20130101) Compositions of Macromolecular Compounds C08L 51/06 (20130101) C08L 2207/062 (20130101) C08L 2312/00 (20130101) C08L 2314/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162544 | Voigt et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| ASSIGNEE(S) | Massachusetts Institute of Technology (Cambridge, Massachusetts) |
| INVENTOR(S) | Christopher A. Voigt (Belmont, Massachusetts); Min-Hyung Ryu (Cambridge, Massachusetts) |
| ABSTRACT | Disclosed herein are engineered rhizobia having nif clusters that enable the fixation of nitrogen under free-living conditions, as well as ammonium and oxygen tolerant nitrogen fixation under free-living conditions. Also provided are methods for producing nitrogen for consumption by a cereal crop using these engineered rhizobia. |
| FILED | Thursday, March 19, 2020 |
| APPL NO | 17/440618 |
| CURRENT CPC | Organic Fertilisers Not Covered by Subclasses C05B, C05C, e.g Fertilisers From Waste or Refuse C05F 11/08 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/20 (20130101) Original (OR) Class C12N 15/87 (20130101) C12N 2510/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162661 | Gonzalez et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Ramon Gonzalez (Tampa, Florida) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ramon Gonzalez (Tampa, Florida); Alexander Chou (Houston, Texas); James Clomburg (Houston, Texas) |
| ABSTRACT | The production of substituted 2-hydroxyacyl-CoA molecules by a novel reaction is described. The reaction involves the condensation of formyl-CoA with a carbonyl-containing molecule. Such carbonyl-containing molecules include a substituted aldehyde and a ketone. The reaction is catalyzed by enzymes using a TPP-dependent mechanism. Also described is the production of unsubstituted and substituted 2-hydroxyacyl-CoA molecules comprising the condensation of formyl-CoA with a carbonyl-containing molecule, wherein the condensation is catalyzed by a prokaryotic HACL. The 2-hydroxyacyl-CoA can be converted to chemical products having broad applications by using enzyme catalysts. The combination of enzyme catalysts comprises novel biochemical reaction pathways that can be deployed either as polypeptides in a reaction buffer or genetically encoded in recombinant microorganisms. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/537714 |
| CURRENT CPC | Fermentation or Enzyme-using Processes to Synthesise a Desired Chemical Compound or Composition or to Separate Optical Isomers From a Racemic Mixture C12P 19/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163379 | Reuel et al. |
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| FUNDED BY |
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| APPLICANT(S) | Iowa State University Research Foundation, Inc. (Ames, Iowa) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Nigel Forest Reuel (Ames, Iowa); Adam Russell Carr (Ames, Iowa) |
| ABSTRACT | According to various aspects, a resonator includes a paper base. The paper base includes a channel bounded by least partially infused wax into the paper base. The resonator further includes an electronically conductive segment physically contacting the paper base. The resonator further includes a hydrogel component coating at least a portion of the electronically conductive segment. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/531103 |
| CURRENT CPC | Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/37 (20130101) Measurement of Mechanical Vibrations or Ultrasonic, Sonic or Infrasonic Waves G01H 13/00 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163389 | Marandi et al. |
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| FUNDED BY |
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| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Alireza Marandi (Pasadena, California); Mingchen Liu (Pasadena, California); Arkadev Roy (Pasadena, California) |
| ABSTRACT | A system for performing spectroscopy, including a first frequency comb source outputting first electromagnetic radiation comprising a first frequency comb centered at a first wavelength and having a first repetition rate; a second frequency comb source outputting a second electromagnetic radiation comprising a second frequency comb centered at a second wavelength and having a second repetition rate; a nonlinear device positioned to receive the first frequency comb and the second frequency comb, wherein the nonlinear device interacts the first frequency comb and the second frequency comb through sum frequency generation or difference frequency generation so as to generate an output electromagnetic radiation; and a detection system outputting a signal in response to detecting an interference of the output electromagnetic radiation with a third electromagnetic radiation, the signal comprising information used for determining a spectrum of at least the first frequency comb or the second frequency comb. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533926 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/027 (20130101) G01J 3/0275 (20130101) G01J 3/4338 (20130101) Original (OR) Class G01J 2003/4332 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163413 | Nguyen et al. |
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| FUNDED BY |
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| APPLICANT(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| ASSIGNEE(S) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, California) |
| INVENTOR(S) | Clark T.-C. Nguyen (Oakland, California); Alper Ozgurluk (Berkeley, California) |
| ABSTRACT | An on-chip strain measurement device that uses precision frequency measurements to precisely extract sub-nm displacements, allowing residual strain measurements in a given structural film. Strain-induced gap changes to resonance frequencies use differential strategies to remove bias uncertainty, allowing measurement of sub-nm displacements. Gap-dependent electrical stiffness is used to shift resonance frequencies as structural elements stretch or shrink to relieve strain. An output based on differential frequencies between two proximal structures with unequal stress arm lengths removes uncertainty on the initial gap spacing. The ability to precisely measure the frequency of the high-Q structures allows lifetime stress correction of micromechanical circuits, such as oscillators and filters. |
| FILED | Tuesday, November 30, 2021 |
| APPL NO | 17/537851 |
| CURRENT CPC | Measuring Force, Stress, Torque, Work, Mechanical Power, Mechanical Efficiency, or Fluid Pressure G01L 1/142 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163499 | Hanson et al. |
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| FUNDED BY |
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| APPLICANT(S) | David Hanson (Albuquerque, New Mexico); Patrick Joseph Hudson (Albuquerque, New Mexico); Kaitlyn Johanna Hughes READ (Albuquerque, New Mexico); Laura Green (Albuquerque, New Mexico); Joseph Stinziano (Albuquerque, New Mexico); Tito Busani (Albuquerque, New Mexico); Mahmoud Behzadirad (Albuquerque, New Mexico) |
| ASSIGNEE(S) | UNM Rainforest Innovations (Albuquerque, New Mexico) |
| INVENTOR(S) | David Hanson (Albuquerque, New Mexico); Patrick Joseph Hudson (Albuquerque, New Mexico); Kaitlyn Johanna Hughes READ (Albuquerque, New Mexico); Laura Green (Albuquerque, New Mexico); Joseph Stinziano (Albuquerque, New Mexico); Tito Busani (Albuquerque, New Mexico); Mahmoud Behzadirad (Albuquerque, New Mexico) |
| ABSTRACT | Methods and apparatus for electrical impedance spectroscopy for non-destructive, real-time, tracking of relative water content and stress responses in plants. |
| FILED | Monday, March 30, 2020 |
| APPL NO | 17/599085 |
| CURRENT CPC | Horticulture; Cultivation of Vegetables, Flowers, Rice, Fruit, Vines, Hops or Seaweed; Forestry; Watering A01G 7/00 (20130101) Investigating or Analysing Materials by Determining Their Chemical or Physical Properties G01N 27/223 (20130101) G01N 33/0098 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163616 | RAPPAPORT et al. |
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| FUNDED BY |
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| APPLICANT(S) | New York University (New York, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | THEODORE S. RAPPAPORT (Raleigh, North Carolina); OJAS KANHERE (Brooklyn, New York) |
| ABSTRACT | Exemplary system, method and computer-accessible medium for selecting at least one location of (i) at least one receiver or transceiver or (ii) at least one transmitter or transceiver can be provided. For example, it is possible to facilitate a receipt, from the at least one transmitter or transceiver, of a plurality of signals by the receiver(s) or transceiver(s). Each of the signals has a multipath component. Then, it is possible to determine time of flight (ToF) information and angle of arrival (AoA) information of the multipath components present in the signals. Further, it is possible to determine one or more possible locations of (i) the receiver(s) or transceiver(s) or (ii) the transmitter(s) or transceiver(s) based on the ToF information, the AoA information, and a model of physical surroundings. The location(s) of (i) the receiver(s) or transceiver(s), or (ii) the transmitter(s) or transceiver(s) can be selected based on the one or more possible locations and an extended Kalman filter (“EKF”). |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/668941 |
| CURRENT CPC | Measuring Distances, Levels or Bearings; Surveying; Navigation; Gyroscopic Instruments; Photogrammetry or Videogrammetry G01C 19/00 (20130101) Measuring Linear or Angular Speed, Acceleration, Deceleration, or Shock; Indicating Presence, Absence, or Direction, of Movement G01P 15/00 (20130101) Radio Direction-finding; Radio Navigation; Determining Distance or Velocity by Use of Radio Waves; Locating or Presence-detecting by Use of the Reflection or Reradiation of Radio Waves; Analogous Arrangements Using Other Waves G01S 5/0218 (20200501) G01S 5/0268 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163883 | Kim et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | The Board of Trustees of the University of Illinois (Urbana, Illinois) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Seok Kim (Champaign, Illinois); Hohyun Keum (Champaign, Illinois); Jun Kyu Park (Champaign, Illinois) |
| ABSTRACT | A method of making a bonded polymeric assembly by transfer printing comprises contacting a stamp with a solid-phase ink comprising a photoresist to form an inked stamp, where the solid-phase ink is reversibly bound to the stamp. The inked stamp is aligned with an object comprising the photoresist and is stamped onto the object. The stamp is then removed, thereby transferring the solid-phase ink onto the object. The solid-phase ink is thermally joined with the object. Thus, a bonded polymeric assembly comprising a bonded joint between the solid-phase ink and the object is formed. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/670070 |
| CURRENT CPC | Specific Uses or Applications of Nanostructures; Measurement or Analysis of Nanostructures; Manufacture or Treatment of Nanostructures B82Y 40/00 (20130101) Photomechanical Production of Textured or Patterned Surfaces, e.g for Printing, for Processing of Semiconductor Devices; Materials Therefor; Originals Therefor; Apparatus Specially Adapted Therefor; G03F 7/0002 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220164189 | Balasubramanian et al. |
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| FUNDED BY |
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| APPLICANT(S) | Mahesh Balasubramanian (Tempe, Arizona); Aviral Shrivastava (Phoenix, Arizona) |
| ASSIGNEE(S) | Arizona Board of Regents on Behalf of Arizona State University (Tempe, Arizona) |
| INVENTOR(S) | Mahesh Balasubramanian (Tempe, Arizona); Aviral Shrivastava (Phoenix, Arizona) |
| ABSTRACT | Various embodiments of a system and associated method for generating a valid mapping for a computational loop on a CGRA are disclosed herein. In particular, the method includes generating randomized schedules within particular constraints to explore greater mapping spaces than previous approaches. Further, the system and related method employs a feasibility test to test validity of each schedule such that mappings are only generated from valid schedules. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533663 |
| CURRENT CPC | Electric Digital Data Processing G06F 9/3001 (20130101) G06F 9/30065 (20130101) Original (OR) Class G06F 9/44505 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220164694 | Rosenthal et al. |
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| FUNDED BY |
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| APPLICANT(S) | The Regents of the University of Colorado, a body corporate (Denver, Colorado); Universitat Innsbruck (Innsbruck, Austria) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Eric Rosenthal (Boulder, Colorado); Konrad Lehnert (Boulder, Colorado); Christian Schneider (Innsbruck, Austria) |
| ABSTRACT | Technology is disclosed herein that the enhances the measurability and scalability of qubits in a quantum computing environment. In an implementation, a superconducting amplifier device comprises a parametric amplifier and a tunable coupling between the parametric amplifier and a readout cavity external to the superconducting amplifier device. The tunable coupling allows an entangled signal, associated with a qubit in the readout cavity, to transfer from the readout cavity to the parametric amplifier. The parametric amplifier amplifies the entangled signal to produce an amplified signal as output to a measurement sub-system. |
| FILED | Thursday, March 04, 2021 |
| APPL NO | 17/192479 |
| CURRENT CPC | Computer Systems Based on Specific Computational Models G06N 10/40 (20220101) Original (OR) Class Amplifiers H03F 19/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220165420 | Wu et al. |
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| FUNDED BY |
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| APPLICANT(S) | Villanova University (Villanova, Pennsylvania); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| ASSIGNEE(S) | Villanova University (Villanova, Pennsylvania); The Trustees of the University of Pennsylvania (Philadelphia, Pennsylvania) |
| INVENTOR(S) | Qianhong Wu (Malvern, Pennsylvania); Sridhar Santhanam (Collegeville, Pennsylvania); Bchara Sidnawi (Villanova, Pennsylvania); Chandra M. Sehgal (Wayne, Pennsylvania) |
| ABSTRACT | The present disclosure relates to a diagnostic tool, and, more particularly, to a diagnostic tool for analyzing and using the results of a flow mediated dilation test. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/530805 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 5/0285 (20130101) Image Data Processing or Generation, in General G06T 7/0012 (20130101) G06T 2207/10132 (20130101) G06T 2207/20084 (20130101) G06T 2207/30104 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 30/20 (20180101) G16H 50/20 (20180101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166458 | Chopra et al. |
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| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); University of Notre Dame du Lac (South Bend, Indiana) |
| INVENTOR(S) | Aditya Chopra (Austin, Texas); Ralf Bendlin (Cedar Park, Texas); Nicholas Joseph Estes (South Bend, Indiana); Kang Gao (San Diego, California); Bertrand Martyn Hochwald (South Bend, Indiana); Jonathan David Chisum (South Bend, Indiana) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, generating multiple digital reference pulses synchronously to a master oscillator, selectively switching the multiple digital reference pulses, and providing the switched pulses to multiple radio modules operating within a millimeter wave spectrum. For each radio module, counting cycles of an adjustable LO output signal occurring between consecutive pulses of the switched digital reference pulses, determining a difference between the count value and a reference value, and adjusting the adjustable LO according to the difference. A resulting corrected LO signal is synchronized to the master oscillator. Other embodiments are disclosed. |
| FILED | Monday, December 20, 2021 |
| APPL NO | 17/556148 |
| CURRENT CPC | Transmission H04B 1/0003 (20130101) H04B 1/50 (20130101) Original (OR) Class H04B 1/0082 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166655 | Bendlin et al. |
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| FUNDED BY |
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| APPLICANT(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); University of Notre Dame du Lac (South Bend, Indiana) |
| ASSIGNEE(S) | AT and T Intellectual Property I, L.P. (Atlanta, Georgia); University of Notre Dame du Lac (South Bend, Indiana) |
| INVENTOR(S) | Ralf Bendlin (Cedar Park, Texas); Aditya Chopra (Austin, Texas); Bertrand Martyn Hochwald (South Bend, Indiana); Nicholas Joseph Estes (South Bend, Indiana); Jonathan David Chisum (South Bend, Indiana); Kang Gao (San Diego, California) |
| ABSTRACT | Aspects of the subject disclosure may include, for example, receiving a radio frequency (RF) signal having a carrier wave component that operates at a carrier frequency within a millimeter wave spectrum. The RF signal also includes an information component based on a phase shift keying (PSK) modulation of the carrier wave component. A local oscillator (LO) signal is obtained, which includes an LO frequency that approximates the carrier frequency. The received RF signal and the LO signal are combined without using signal multiplication to obtain a first combined output signal. The first combined output signal being detected via a non-linear energy detector to obtain a first detected signal. The first output signal includes information of the information component. Other embodiments are disclosed. |
| FILED | Friday, July 30, 2021 |
| APPL NO | 17/390414 |
| CURRENT CPC | Transmission H04B 7/0413 (20130101) Transmission of Digital Information, e.g Telegraphic Communication H04L 27/22 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220167236 | Melodia et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Northeastern University (Boston, Massachusetts) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Tommaso Melodia (Newton, Massachusetts); Salvatore D'Oro (Allston, Massachusetts); Michele Polese (Boston, Massachusetts); Leonardo Bonati (Boston, Massachusetts) |
| ABSTRACT | A radio access network (RAN) intelligent controller (RIC) and corresponding method may be implemented within RAN and in next-generation cellular networks to improve performance. The RIC comprises an interface to a RAN and further comprises a data-driven logic unit. The data-driven logic unit (i) produces, based on data received from the RAN via the interface, a representation describing a state of the RAN and (ii) based on the representation describing the state, instructs an action associated with at least one network element. The interface transmits a message based on the action instructed. The message is to be routed to the at least one network element. The representation is based on a context of the RAN. The message transmitted enabling re-configuration of the at least one network element. The re-configuration improves performance of the at least one network element within the context. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/456361 |
| CURRENT CPC | Transmission H04B 17/336 (20150115) Wireless Communication Networks H04W 28/24 (20130101) H04W 28/0236 (20130101) H04W 28/0967 (20200501) H04W 36/06 (20130101) Original (OR) Class H04W 36/30 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Aeronautics and Space Administration (NASA)
| US 20220162403 | Kirmani et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Mohammad Hamza Kirmani (Atlanta, Georgia); Prabhakar Gulgunje (Atlanta, Georgia); Satish Kumar (Atlanta, Georgia) |
| ABSTRACT | In a method of making a material, a bismaleimide system is heated to generate a bismaleimide liquid (110). The bismaleimide liquid is degassed (114) to generate a degassed bismaleimide liquid. At least one of high speed shear mixing and probe sonication is performed to the degassed bismaleimide liquid to generate a highly mixed bismaleimide liquid phase (112). The highly mixed bismaleimide liquid phase is cured (116). A bismaleimide product is made by heating a three component bismaleimide system to generate a bismaleimide liquid, which is degassed in a 30 mbar vacuum until no new visually perceptible bubbles are detected. The degassed liquid is high speed shear mixed at a speed of 3500 RPM for 10 minutes to generate a highly mixed bismaleimide liquid phase, which is cured to make the bismaleimide product. A substance includes cured bismaleimide having an impact strength in a range of 56 kJ/m2 to 82 kJ/m2. |
| FILED | Friday, April 17, 2020 |
| APPL NO | 17/601863 |
| CURRENT CPC | Working-up; General Processes of Compounding; After-treatment Not Covered by Subclasses C08B, C08C, C08F, C08G or C08H C08J 3/247 (20130101) Original (OR) Class C08J 2379/08 (20130101) Use of Inorganic or Non-macromolecular Organic Substances as Compounding Ingredients C08K 3/041 (20170501) C08K 3/042 (20170501) C08K 3/046 (20170501) C08K 7/06 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162992 | Pal |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Hamilton Sundstrand Corporation (Charlotte, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Debabrata Pal (Hoffman Estates, Illinois) |
| ABSTRACT | Provided are embodiments for a feeder cooling tube, a system and method for performing thermal management. Embodiments include a feeder cooling tube having an inner tube arranged to define a path to flow a fluid through a length of the inner tube, wherein the fluid is provided to remove heat, and an outer tube arranged to enclose the inner tube which defines an area. Embodiments also include one or more feeder cables arranged between the inner tube and the outer tube, and a plurality of cooling struts, wherein each cooling strut of the plurality of cooling struts extends from a surface of the inner tube to a surface of the outer tube. |
| FILED | Tuesday, November 24, 2020 |
| APPL NO | 17/102771 |
| CURRENT CPC | Gas-turbine Plants; Air Intakes for Jet-propulsion Plants; Controlling Fuel Supply in Air-breathing Jet-propulsion Plants F02C 7/14 (20130101) Original (OR) Class F02C 7/16 (20130101) Indexing Scheme for Aspects Relating to Non-positive-displacement Machines or Engines, Gas-turbines or Jet-propulsion Plants F05D 2210/11 (20130101) F05D 2260/98 (20130101) F05D 2260/213 (20130101) Cables; Conductors; Insulators; Selection of Materials for Their Conductive, Insulating or Dielectric Properties H01B 7/423 (20130101) Dynamo-electric Machines H02K 9/19 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220163389 | Marandi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | California Institute of Technology (Pasadena, California) |
| ASSIGNEE(S) | California Institute of Technology (Pasadena, California) |
| INVENTOR(S) | Alireza Marandi (Pasadena, California); Mingchen Liu (Pasadena, California); Arkadev Roy (Pasadena, California) |
| ABSTRACT | A system for performing spectroscopy, including a first frequency comb source outputting first electromagnetic radiation comprising a first frequency comb centered at a first wavelength and having a first repetition rate; a second frequency comb source outputting a second electromagnetic radiation comprising a second frequency comb centered at a second wavelength and having a second repetition rate; a nonlinear device positioned to receive the first frequency comb and the second frequency comb, wherein the nonlinear device interacts the first frequency comb and the second frequency comb through sum frequency generation or difference frequency generation so as to generate an output electromagnetic radiation; and a detection system outputting a signal in response to detecting an interference of the output electromagnetic radiation with a third electromagnetic radiation, the signal comprising information used for determining a spectrum of at least the first frequency comb or the second frequency comb. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/533926 |
| CURRENT CPC | Measurement of Intensity, Velocity, Spectral Content, Polarisation, Phase or Pulse Characteristics of Infra-Red, Visible or Ultra-violet Light; Colorimetry; Radiation Pyrometry G01J 3/027 (20130101) G01J 3/0275 (20130101) G01J 3/4338 (20130101) Original (OR) Class G01J 2003/4332 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220165448 | Choi et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINSTRATOR OF NASA (WASHINGTON, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Sang H. Choi (POQUOSON, Virginia); Dennis M. Bushnell (HAMPTON, Virginia); David R. Komar (Hampton, Virginia); Robert C. Hendricks (CLEVELAND, Ohio) |
| ABSTRACT | The present disclosure is directed to a nuclear thermionic avalanche cell (NTAC) systems and related methods of generating energy comprising a radioisotope core, a plurality of thin-layered radioisotope sources configured to emit high energy beta particles and high energy photons, and a plurality of NTAC layers integrated with the radioisotope core and the radioisotope sources, wherein the plurality of NTAC layers are configured to receive the beta particles and the photons from the radioisotope core and sources, and by the received beta particles and photons, free up electrons in an avalanche process from deep and intra bands of an atom to output a high density avalanche cell thermal energy through a photo-ionic or thermionic process of the freed up electrons. |
| FILED | Monday, January 10, 2022 |
| APPL NO | 17/571765 |
| CURRENT CPC | Conversion of Chemical Elements; Radioactive Sources G21G 1/12 (20130101) G21G 2001/0094 (20130101) Obtaining Energy From Radioactive Sources; Applications of Radiation From Radioactive Sources, Not Otherwise Provided For; Utilising Cosmic Radiation G21H 1/04 (20130101) Original (OR) Class G21H 1/12 (20130101) G21H 1/103 (20130101) G21H 3/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166010 | YUSHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies Inc. (Alameda, California) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Oleksandr MAGAZYNSKYY (Atlanta, Georgia); Patrick DIXON (Dunwoody, Georgia); Benjamin HERTZBERG (New York, New York) |
| ABSTRACT | Described herein are improved composite anodes and lithium-ion batteries made therefrom. Further described are methods of making and using the improved anodes and batteries. In general, the anodes include a porous composite having a plurality of agglomerated nanocomposites. At least one of the plurality of agglomerated nanocomposites is formed from a dendritic particle, which is a three-dimensional, randomly-ordered assembly of nanoparticles of an electrically conducting material and a plurality of discrete non-porous nanoparticles of a non-carbon Group 4A element or mixture thereof disposed on a surface of the dendritic particle. At least one nanocomposite of the plurality of agglomerated nanocomposites has at least a portion of its dendritic particle in electrical communication with at least a portion of a dendritic particle of an adjacent nanocomposite in the plurality of agglomerated nanocomposites. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667412 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/137 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 4/602 (20130101) H01M 4/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166011 | YUSHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Oleksandr MAGAZYNSKYY (Atlanta, Georgia); Patrick DIXON (Dunwoody, Georgia); Benjamin HERTZBERG (New York, New York) |
| ABSTRACT | Described herein are improved composite anodes and lithium-ion batteries made therefrom. Further described are methods of making and using the improved anodes and batteries. In general, the anodes include a porous composite having a plurality of agglomerated nanocomposites. At least one of the plurality of agglomerated nanocomposites is formed from a dendritic particle, which is a three-dimensional, randomly-ordered assembly of nanoparticles of an electrically conducting material and a plurality of discrete non-porous nanoparticles of a non-carbon Group 4A element or mixture thereof disposed on a surface of the dendritic particle. At least one nanocomposite of the plurality of agglomerated nanocomposites has at least a portion of its dendritic particle in electrical communication with at least a portion of a dendritic particle of an adjacent nanocomposite in the plurality of agglomerated nanocomposites. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667427 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/137 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 4/602 (20130101) H01M 4/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Agriculture (USDA)
| US 20220159953 | Kim |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The United States of America, as represented by the Secretary of Agriculture (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Jong Heon Kim (Albany, California) |
| ABSTRACT | Disclosed are methods of protecting seeds from oxidants and microorganisms prior to planting said seed, involving coating the seeds with an antioxidant effective amount and an antimicrobial effective amount of a composition containing at least one compound selected from the group consisting of C7-18 gallates in an optional solvent and/or optional carrier prior to planting the seeds, and heating the seeds to a temperature of about 20° C. to about 70° C. for about 5 minutes to about 60 minutes prior to planting the seeds. |
| FILED | Thursday, October 28, 2021 |
| APPL NO | 17/513192 |
| CURRENT CPC | Preservation of Bodies of Humans or Animals or Plants or Parts Thereof; Biocides, e.g as Disinfectants, as Pesticides or as Herbicides; Pest Repellants or Attractants; Plant Growth Regulators A01N 37/40 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160822 | Talaat et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Wisconsin Alumni Research Foundation (Madison, Wisconsin) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Adel M. Talaat (Madison, Wisconsin); Shaswath Chandrasekar (Madison, Wisconsin) |
| ABSTRACT | The present invention provides both QuilA-loaded chitosan (QAC)-encapsulated DNA vaccine compositions and viral vaccine compositions that encode a SARs-CoV-2 spike (S) protein, a SARs-CoV-2 nucleocapsid (N) protein, or both the S protein and the N protein. Additionally, the present invention provides methods in which the disclosed vaccines are administered to a subject to induce an immune response against SARS-CoV-2. |
| FILED | Tuesday, November 23, 2021 |
| APPL NO | 17/534002 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/162 (20130101) Original (OR) Class A61K 2039/55583 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 31/14 (20180101) Peptides C07K 14/165 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162545 | Ibrahim et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | North Carolina Agricultural and Technical State University (Greensboro, North Carolina) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Salam Ibrahim (Greensboro, North Carolina); Tahl Zimmerman (Greensboro, North Carolina) |
| ABSTRACT | The presently disclosed subject matter relates generally to inexpensive and sustainable compositions and methods to support growth of certain bacteria. In particular, the presently disclosed methods and compositions do not rely on addition of enzymatic components to support the growth of bacteria. |
| FILED | Friday, November 19, 2021 |
| APPL NO | 17/530649 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 1/04 (20130101) C12N 1/20 (20130101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Veterans Affairs (DVA)
| US 20220160208 | Liao et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); U.S. Government Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | The Board of Trustees of the Leland Stanford Junior University (Stanford, California); U.S. Government Represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Joseph C. Liao (Stanford, California); Lei Xing (Stanford, California); Eugene Shkolyar (Stanford, California); Xiao Jia (Stanford, California) |
| ABSTRACT | Over 2 million cystoscopies are performed annually in the United States and Europe for detection and surveillance of bladder cancer. Adequate identification of suspicious lesions is critical to minimizing recurrence and progression rates, however standard cystoscopy misses up to 20% of bladder cancer. Access to adjunct imaging technology may be limited by cost and availability of experienced personnel. Machine learning holds the potential to enhance medical decision-making in cancer detection and imaging. Various embodiments described herein are directed to methods for identifying cancers, tumors, and/or other abnormalities present in a person's bladder. Additional embodiments are directed to machine learning systems to identify cancers, tumors, and/or other abnormalities present in a person's bladder, while additional embodiments will also identify benign or native structures or features in a person's bladder. Further embodiments incorporate such systems into cystoscopy equipment to allow for real time and/or immediate detection of cancers, tumors, and/or other abnormalities present in a person's bladder during a cystoscopy procedure. |
| FILED | Friday, April 03, 2020 |
| APPL NO | 17/601377 |
| CURRENT CPC | Diagnosis; Surgery; Identification A61B 1/06 (20130101) A61B 1/000096 (20220201) Original (OR) Class A61B 1/307 (20130101) Image Data Processing or Generation, in General G06T 7/10 (20170101) G06T 2207/10016 (20130101) G06T 2207/10068 (20130101) G06T 2207/20081 (20130101) G06T 2207/20084 (20130101) G06T 2207/30096 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220160587 | Kearns et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | William Diehl Kearns (Tampa, Florida); Kimberly Ann Crosland (Lithia, Florida); Jeffrey D. Craighead (Groveland, Florida); James Leonard Fozard (Palm Harbor, Florida) |
| ASSIGNEE(S) | University of South Florida (Tampa, Florida); The United States Government as represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | William Diehl Kearns (Tampa, Florida); Kimberly Ann Crosland (Lithia, Florida); Jeffrey D. Craighead (Groveland, Florida); James Leonard Fozard (Palm Harbor, Florida) |
| ABSTRACT | A medication adherence system and corresponding medication box for improving medication adherence. The system includes the medication box, which is transparent and has a machine-readable marker, such as a QR code, on or beneath the floor thereof. The marker is capable of being scanned and read through the transparent bottoms of individual chambers. Data embedded in the marker includes, but is not limited to, the user's medication plan, the date and time when the medication is to be ingested, and instructions for recording the date and time when the marker is scanned and read. The underlying software program/application processes this information and provides an indication as to the user's compliance with the medication plan. |
| FILED | Monday, February 14, 2022 |
| APPL NO | 17/670808 |
| CURRENT CPC | Containers Specially Adapted for Medical or Pharmaceutical Purposes; Devices or Methods Specially Adapted for Bringing Pharmaceutical Products into Particular Physical or Administering Forms; Devices for Administering Food or Medicines Orally; Baby Comforters; Devices for Receiving Spittle A61J 7/0069 (20130101) A61J 7/0076 (20130101) A61J 7/0092 (20130101) A61J 7/0418 (20150501) A61J 7/0445 (20150501) A61J 7/0481 (20130101) Original (OR) Class A61J 2200/30 (20130101) Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 19/06028 (20130101) Healthcare Informatics, i.e Information and Communication Technology [ICT] Specially Adapted for the Handling or Processing of Medical or Healthcare Data G16H 20/13 (20180101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220162279 | DUBINETT et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Regents of the University of California (Oakland, California); United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| ASSIGNEE(S) | The Regents of the University of California (Oakland, California); United States Government represented by the Department of Veterans Affairs (Washington, District of Columbia) |
| INVENTOR(S) | Steven M. DUBINETT (Los Angeles, California); Sherven SHARMA (Culver City, California); Jay M. LEE (Los Angeles, California) |
| ABSTRACT | The invention is based on the disclosure provided herein that secondary lymphoid organ chemokine (SLC) inhibits the growth of syngeneic tumors in vivo. Thus, the invention provides a method of treating cancer in a mammal subject by administering a therapeutically effective amount of an SLC to the mammal in combination with a checkpoint inhibitor, including monoclonal antibodies and small molecule inhibitors. Exemplary checkpoint molecules include CTLA-4, a CTLA-4 receptor, PD-1, PD1-L1, PD1-L2, 4-1BB, OX40, LAG-3, TIM-3 or a combination thereof. SLCs useful in the methods of the invention include SLC polypeptides, variants and fragments and related nucleic acids. |
| FILED | Tuesday, January 18, 2022 |
| APPL NO | 17/577973 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 9/0019 (20130101) A61K 38/195 (20130101) A61K 39/0011 (20130101) A61K 39/3955 (20130101) A61K 39/39558 (20130101) A61K 45/06 (20130101) A61K 48/00 (20130101) A61K 2039/54 (20130101) A61K 2039/545 (20130101) A61K 2039/5154 (20130101) A61K 2039/5256 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 14/521 (20130101) Original (OR) Class C07K 16/24 (20130101) C07K 16/249 (20130101) C07K 16/2818 (20130101) C07K 2317/76 (20130101) Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 7/00 (20130101) C12N 2710/10041 (20130101) C12N 2710/10043 (20130101) C12N 2710/10071 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Small Business Administration (SBA)
| US 20220162283 | Antipov et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Silver Creek Pharmaceuticals, Inc. (San Francisco, California) |
| ASSIGNEE(S) | Silver Creek Pharmaceuticals, Inc. (San Francisco, California) |
| INVENTOR(S) | Laura D.J. Antipov (Oakland, California); Shawdee Eshghi (Oakland, California); Kristopher M. Kuchenbecker (Phoenix, Arizona); Bjorn L. Millard (Orinda, California); Matthew D. Onsum (El Cerrito, California); Andrea D. Nickerson (San Francisco, California); Timothy R. Stowe (San Francisco, California); Yan Zhang (San Francisco, California) |
| ABSTRACT | Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. |
| FILED | Thursday, February 10, 2022 |
| APPL NO | 17/668825 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 38/00 (20130101) Peptides C07K 14/47 (20130101) C07K 14/65 (20130101) Original (OR) Class C07K 14/765 (20130101) C07K 2319/035 (20130101) C07K 2319/75 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166010 | YUSHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies Inc. (Alameda, California) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Oleksandr MAGAZYNSKYY (Atlanta, Georgia); Patrick DIXON (Dunwoody, Georgia); Benjamin HERTZBERG (New York, New York) |
| ABSTRACT | Described herein are improved composite anodes and lithium-ion batteries made therefrom. Further described are methods of making and using the improved anodes and batteries. In general, the anodes include a porous composite having a plurality of agglomerated nanocomposites. At least one of the plurality of agglomerated nanocomposites is formed from a dendritic particle, which is a three-dimensional, randomly-ordered assembly of nanoparticles of an electrically conducting material and a plurality of discrete non-porous nanoparticles of a non-carbon Group 4A element or mixture thereof disposed on a surface of the dendritic particle. At least one nanocomposite of the plurality of agglomerated nanocomposites has at least a portion of its dendritic particle in electrical communication with at least a portion of a dendritic particle of an adjacent nanocomposite in the plurality of agglomerated nanocomposites. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667412 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/137 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 4/602 (20130101) H01M 4/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
| US 20220166011 | YUSHIN et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Sila Nanotechnologies Inc. (Atlanta, Georgia) |
| ASSIGNEE(S) | Georgia Tech Research Corporation (Atlanta, Georgia) |
| INVENTOR(S) | Gleb YUSHIN (Atlanta, Georgia); Oleksandr MAGAZYNSKYY (Atlanta, Georgia); Patrick DIXON (Dunwoody, Georgia); Benjamin HERTZBERG (New York, New York) |
| ABSTRACT | Described herein are improved composite anodes and lithium-ion batteries made therefrom. Further described are methods of making and using the improved anodes and batteries. In general, the anodes include a porous composite having a plurality of agglomerated nanocomposites. At least one of the plurality of agglomerated nanocomposites is formed from a dendritic particle, which is a three-dimensional, randomly-ordered assembly of nanoparticles of an electrically conducting material and a plurality of discrete non-porous nanoparticles of a non-carbon Group 4A element or mixture thereof disposed on a surface of the dendritic particle. At least one nanocomposite of the plurality of agglomerated nanocomposites has at least a portion of its dendritic particle in electrical communication with at least a portion of a dendritic particle of an adjacent nanocomposite in the plurality of agglomerated nanocomposites. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667427 |
| CURRENT CPC | Processes or Means, e.g Batteries, for the Direct Conversion of Chemical Energy into Electrical Energy H01M 4/38 (20130101) H01M 4/133 (20130101) H01M 4/134 (20130101) H01M 4/137 (20130101) H01M 4/366 (20130101) Original (OR) Class H01M 4/587 (20130101) H01M 4/602 (20130101) H01M 4/625 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Commerce (DOC)
| US 20220162673 | Kung et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Gen9, Inc. (Boston, Massachusetts) |
| ASSIGNEE(S) | Gen9, Inc. (Boston, Massachusetts) |
| INVENTOR(S) | Li-Yun A. Kung (Arlington, Massachusetts); Daniel Schindler (Newton, Massachusetts); Joseph Jacobson (Newton, Massachusetts) |
| ABSTRACT | Methods and devices relate to the isolation of nucleic acids of interest from within a population of nucleic acids such as libraries of nucleic acid sequences. |
| FILED | Monday, November 29, 2021 |
| APPL NO | 17/536828 |
| CURRENT CPC | Microorganisms or Enzymes; Compositions Thereof; Propagating, Preserving, or Maintaining Microorganisms; Mutation or Genetic Engineering; Culture Media C12N 15/1034 (20130101) C12N 15/1065 (20130101) Measuring or Testing Processes Involving Enzymes, Nucleic Acids or Microorganisms; Compositions or Test Papers Therefor; Processes of Preparing Such Compositions; Condition-responsive Control in Microbiological or Enzymological Processes C12Q 1/6806 (20130101) Original (OR) Class C12Q 1/6855 (20130101) C12Q 2525/191 (20130101) C12Q 2533/107 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Department of Homeland Security (DHS)
| US 20220161403 | Regan et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| ASSIGNEE(S) | The Government of the United States of America, as represented by the Secretary of Homeland Security (Washington, District of Columbia) |
| INVENTOR(S) | Mary Shalane Regan (Groton, Connecticut); James P. Sullivan (Elizabeth City, North Carolina) |
| ABSTRACT | A negator spring tool for winding a negator spring output drum around a rotational axis includes: a pair of tool handles; and a tool disk having an outer edge which is generally circular except for a cutout. The tool disk is configured to be releasably attached to the output drum. The tool disk has a drum-facing side which includes protruding teeth protruding from the drum-facing side to engage radial spokes of the output drum. The outer edge of the tool disk includes handle slots which are spaced circumferentially. The distal end of each tool handle is insertable into a handle slot to rotate the tool disk around the rotational axis. The protruding teeth of the tool disk each having a T-shaped cross section, each T-shaped protruding tooth and the drum-facing side forming an I-shaped cross section having two opposite facing cavities on two opposite sides of the I-shaped cross section. |
| FILED | Tuesday, February 08, 2022 |
| APPL NO | 17/667409 |
| CURRENT CPC | Tools or Bench Devices Not Otherwise Provided For, for Fastening, Connecting, Disengaging or Holding B25B 27/306 (20130101) Original (OR) Class Aeroplanes; Helicopters B64C 1/1423 (20130101) Indexing Scheme Relating to Hinges or Other Suspension Devices for Doors, Windows or Wings and Devices for Moving Wings into Open or Closed Position, Checks for Wings and Wing Fittings Not Otherwise Provided For, Concerned With the Functioning of the Wing E05Y 2900/502 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
National Security Agency (NSA)
| US 20220166705 | Froese |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | Hewlett Packard Enterprise Development LP (Houston, Texas) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Edwin L. Froese (Burnaby British Columbia, California) |
| ABSTRACT | Systems and methods are provided for managing a data communication within a multi-level network having a plurality of switches organized as groups, with each group coupled to all other groups via global links, including: at each switch within the network, maintaining a global fault table identifying the links which lead only to faulty global paths, and when the data communication is received at a port of a switch, determine a destination for the data communication and, route the communication across the network using the global fault table to avoid selecting a port within the switch that would result in the communication arriving at a point in the network where its only path forward is across a global link that is faulty; wherein the global fault table is used for both a global minimal routing methodology and a global non-minimal routing methodology. |
| FILED | Monday, March 23, 2020 |
| APPL NO | 17/594711 |
| CURRENT CPC | Transmission of Digital Information, e.g Telegraphic Communication H04L 45/22 (20130101) H04L 45/028 (20130101) H04L 45/28 (20130101) Original (OR) Class H04L 45/125 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Office of the Director of National Intelligence (ODNI)
| US 20220164692 | Inoue et al. |
|---|---|
| FUNDED BY |
|
| APPLICANT(S) | International Business Machines Corporation (Armonk, New York) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Ken Inoue (Elmsford, New York); Maika Takita (Croton-on-Hudson, New York); Antonio Corcoles-Gonzalez (Mount Kisco, New York); Scott Douglas Lekuch (New York, New York) |
| ABSTRACT | Systems, computer-implemented methods, and computer program products that can facilitate determining a state of a qubit are described. According to an embodiment, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise an output receiving component that can receive, in response to a request, output representative of a quantum state of a qubit of a quantum computing device, and a classifying component that classifies the quantum state of the qubit of the quantum computing device based on the output representative of the quantum state of the qubit. The system can further include a configuring component that can configure the classifying component based on a characteristic of the request. |
| FILED | Thursday, November 07, 2019 |
| APPL NO | 16/677178 |
| CURRENT CPC | Recognition of Data; Presentation of Data; Record Carriers; Handling Record Carriers G06K 9/6269 (20130101) Computer Systems Based on Specific Computational Models G06N 10/20 (20220101) Original (OR) Class |
| VIEW PATENT | @ USPTO: Full Text PDF |
U.S. State Government
| US 20220160678 | LI et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| ASSIGNEE(S) | Board of Regents, The University of Texas System (Austin, Texas) |
| INVENTOR(S) | Rong LI (Washington, District of Columbia); Bin YUAN (Hefei City, China PRC); Kate Ida LATHROP (San Antonio, Texas) |
| ABSTRACT | The present invention provides methods and compositions for modulating molecular markers, and hence treating or preventing breast cancer (e.g., triple-negative breast cancer) and melanoma with a pharmaceutically effective amount of S-equol or a pharmaceutical composition comprising S-equol. The S-equol may be administered alone or in combination with one or more cytotoxic or immunotherapeutic compound or molecule. |
| FILED | Wednesday, November 24, 2021 |
| APPL NO | 17/535125 |
| CURRENT CPC | Preparations for Medical, Dental, or Toilet Purposes A61K 31/353 (20130101) Original (OR) Class A61K 39/39541 (20130101) A61K 2039/505 (20130101) Specific Therapeutic Activity of Chemical Compounds or Medicinal Preparations A61P 35/00 (20180101) Peptides C07K 16/2818 (20130101) C07K 16/2827 (20130101) C07K 2317/21 (20130101) C07K 2317/24 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
United States Postal Service (USPS)
| US 20220162020 | Stratton et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | United States Postal Service (Washington, District of Columbia) |
| ASSIGNEE(S) | |
| INVENTOR(S) | Christopher M. Stratton (Springfield, Virginia); Gregory J. Smith (Arlington, Virginia); Thomas C. Potter (Oak Hill, Virginia); Wayne R. Perry-Eaton (Leesburg, Virginia) |
| ABSTRACT | Features for loading, transporting and unloading of items are disclosed. Systems, devices and methods for such operations using a tray are described. In some embodiments, a tray having a moveable bottom allows for switching between a configuration for loading and unloading items in and out of the tray and a configuration for transportation of items inside the tray. The trays may also be stacked, for transportation of multiple trays at once, and nested, for saving space when storing the trays. In some embodiments, the trays may be used in conjunction with loading and unloading systems. |
| FILED | Friday, February 11, 2022 |
| APPL NO | 17/650831 |
| CURRENT CPC | Transport or Storage Devices, e.g Conveyors for Loading or Tipping, shop Conveyor Systems Or pneumatic Tube Conveyors B65G 65/32 (20130101) Original (OR) Class B65G 65/34 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
Government Rights Acknowledged
| US 20220166513 | Wolff et al. |
|---|---|
| FUNDED BY |
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| APPLICANT(S) | Raytheon Applied Signal Technology, Inc. (Sunnyvale, California) |
| ASSIGNEE(S) | Raytheon Applied Signal Technology, Inc. (Sunnyvale, California) |
| INVENTOR(S) | Vincent Wolff (Mountain View, California); Kevin Lundgreen (Fruit Heights, Utah) |
| ABSTRACT | A polarization dependent loss (PDL) compensation device for an optical system can be configured to output a compensating PDL to at least partially cancel a PDL of the optical system. In certain embodiments, the device can include a first polarization controller configured to modify a state of polarization of an optical signal, a PDL emulator disposed upstream of the first polarization controller and configured to output the compensating PDL upstream of the first polarization controller, and a second polarization controller disposed upstream of the PDL emulator and configured to modify a state of polarization of the optical signal upstream of the PDL emulator. |
| FILED | Friday, November 20, 2020 |
| APPL NO | 17/100583 |
| CURRENT CPC | Optical Elements, Systems, or Apparatus G02B 6/2793 (20130101) Transmission H04B 10/038 (20130101) H04B 10/2569 (20130101) H04B 10/2572 (20130101) Original (OR) Class H04B 10/6161 (20130101) |
| VIEW PATENT | @ USPTO: Full Text PDF |
How To Use This Page
THE FEDINVENT PATENT APPLICATION DETAILS PAGE
Each week, FedInvent analyzes newly granted patents and published patent applications whose origins lead back to funding by the US Federal Government. The FedInvent Patent Details page is a companion to the weekly FedInvents Patents Report.
This week's information is published in the FedInvent Patents report for Thursday, May 26, 2022.
The FedInvent Weekly Patent Details Page contains a subset of patent information to provide a deeper dive into the week's taxpayer-funded patents to help the reader better understand where a patent fits in the federal innovation ecosphere.
HOW IS THE INFORMATION ORGANIZED?
Patents are organized by the funding agency. Within each group, the patents are organized in numeric order. A patent funded by more than one agency will appear in the section of each of the agencies that funded the research and development that resulted in the invention. This approach gives the reader a complete view of the department or agency activity for the week.
WHAT INFORMATION WILL I FIND?
THE PANEL
There is a panel for each patent that contains the patent number and the title of the patent. When you click the panel, it opens to reveal the following information:
FUNDED BY
The agencies that funded the grants, contracts, or other research agreements that resulted in the patent. FedInvent includes as much information on the source of the funding as possible. The information is presented in a hierarchy going from the Federal Department down to the agencies, subagencies, and offices that funded the work. Here are two examples:
Department of Health and Human Services (HHS)
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Department of Defense (DOD)
Defense Advanced Research Projects Agency (DARPA)
Army Research Office (ARO)
We do our best to provide detailed information about the funding. In some cases, the patent only reports limited information on the origins of the funding. FedInvents presents what it can confirm. We add the patents without the information required by the Bayh-Dole Act to our list of patents worthy of further investigation.
APPLICANT(S) and ASSIGNEES
FedInvent includes both the Applicants and the Assignees because having both provides more information about where the inventive work was done and by what organizations. Many organizations — universities, corporations, and federal agencies — standardize the Assignee/Owner information by the time a patent is granted. In the case of federal patents, many of the patents use the agency headquarters information for patent assignment.
Showing just the headquarters address would make Washington, DC the epicenter of all taxpayer-funded research and development. Providing both the applicant information and the assignee information provides a more accurate picture of where important taxpayer-funded innovation is happening in America. Here are two examples from two different patents:
APPLICANT: U.S. Army Research Laboratory, Adelphi, MD
ASSIGNEE: The United States of America as represented by the Secretary of the Army Washington, DC
APPLICANT: Optech Ventures, LLC (Torrance, California)
ASSIGNEE(S): The Regents of the University of California (Oakland, California); Optech Ventures, LLC (Torrance, California)
INVENTOR(S)
The inventors appear in the same order as they appear on the patent. FedInvents presents the names in first name/last name order because they are easier to read than the last name/first name order of the names on the USPTO patent documents.
ABSTRACT
The abstract is presented as it appears on the patent.
FILED
The date the patent application including the day of the week.
APPL NO
This is the patent application serial number. If you’d like to learn more about how application serial numbers work you can go to the Lists Page.
ART UNIT
Patent data includes the Art Unit where a patent was examined. (The Art Unit isn’t available for published patent applications.) The Art Unit provides insight into what group of patent examiners prosecuted the patent application and the subject matter that the examiners work on. For example:
3793 — Medical Instruments, Diagnostic Equipment, and Treatment Devices
You can learn more about ART UNITS on the FedInvent Patents Weekly panel called About Tech Center or you can find information on the FedInvent Lists Page.
CURRENT CPC
Current CPC provides a list of the Cooperative Patent Classification symbols assigned to the patent. These are the CPC symbols assigned at the time the patent was granted.
The FedInvent Project is a patent classification maximalist endeavor or put another way, we believe that the more you understand about patent classification the more you'll learn about the nature of the invention and the types of work that the federal government is funding.
The symbol presented in BOLD is the symbol identified as the "first" classification which is the most relevant classification on the patent. The date that follows the symbol is the date of the most recent revision to the art classed there.
- A61B 1/149 (20130101)
- A61B 1/71 (20130101)
- A61B 1/105 (20130101)
The CPC symbols match the classifications found on the PDF version of the patent. Over time, the classifications on the full text version of the patent change to reflect how USPTO organizes patent art to support its examiners. The two sets of CPCs don’t always match.
VIEW PATENT
As of June 2021, we include two ways to view a patent at USPTO. FedInvent provides a link to the Full-Text Version of the patent and a link to the PDF version of the patent.
HOW DO I FIND A SPECIFIC PATENT ON A PAGE?
You can use the Command F or Control F to find a specific patent you are interested in.
HOW DO I GET HERE?
You navigate to the details of a patent by clicking the information icon that follows a patent on the FedInvent Patents Weekly Report.
You can also reach this page using the weekly page link that looks like this:
https://wayfinder.digital/fedinvent/patents-2022/fedinvent-applications-20220526.html
Just update the date portion of the URL. Tuesdays for patents. Thursdays for pre-grant publication of patent applications.
Download a copy of the How To Use This Page